FASTA searches a protein or DNA sequence data bank
version 3.4t11 Apr 17, 2002
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
../query/mKIAA4231.ptfa, 1467 aa
vs ./tmplib.26680 library
1767550 residues in 2168 sequences
Expectation_n fit: rho(ln(x))= 15.3527+/-0.0113; mu= -34.1261+/- 0.743
mean_var=757.9020+/-186.917, 0's: 0 Z-trim: 22 B-trim: 0 in 0/36
Lambda= 0.0466
FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 40, opt: 28, open/ext: -10/-2, width: 16
The best scores are: opt bits E(2168)
mKIAA1870 ( 857 res) mtj02754 ( 857) 1894 144 1.5e-34
mFLJ00201 ( 640 res) mpm06260 ( 640) 1560 121 6.9e-28
mKIAA4178 ( 1796 res) mtg01289 (1796) 686 63 7e-10
mKIAA0824 ( 1641 res) mth01748 (1641) 421 45 0.00015
mKIAA0689 ( 643 res) mfj03025 ( 643) 373 41 0.00072
mKIAA1236 ( 1309 res) mpm04158 (1309) 372 42 0.0013
mKIAA1139 ( 1224 res) mpg00286 (1224) 360 41 0.0021
mKIAA1983 ( 426 res) mbp99003 ( 426) 326 38 0.0048
>>mKIAA1870 ( 857 res) mtj02754 (857 aa)
initn: 3775 init1: 1010 opt: 1894 Z-score: 712.7 bits: 143.7 E(): 1.5e-34
Smith-Waterman score: 2429; 42.167% identity (46.730% ungapped) in 932 aa overlap (552-1467:1-857)
530 540 550 560 570 580
mKIAA4 VAGEPGRDGTPGGPGIRGMPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMG
.:: : .:. : :::: ::.:. ::
mKIAA1 EPGIVGEKGDRGVMGPPGAPGPKGS---MG
10 20
590 600 610 620 630 640
mKIAA4 FPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGETGPQGPPGPTGPAGDKGDSGPPGPQG
:: :. : ::. : : ::. :::: : .:. ::.:: ::.: :.:: .: ::.:
mKIAA1 HPGTPGGIGNPGEPGPWGPPGSRGLPGMRGAKGHRGPRGPDGPAGEQGSKGLKGRVGPRG
30 40 50 60 70 80
650 660 670 680 690 700
mKIAA4 LQGIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGKGDSGAPGERGPPGTAGIPGARGGAG
.::.:: .: .: : :.:: : :: ::::. :.:: :. :
mKIAA1 ---------------RPGQPGQQGAAGERGHSGAKGFLGIPGPSGPPGAKGLPGEPGSQG
90 100 110 120 130
710 720 730 740 750 760
mKIAA4 PPGPEGGKGPAGPPGPPGASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDG
: :: : : :: ::::: : ::: ::. : :. :: : :: : : : :: .:
mKIAA1 PQGPVGPPGEMGPKGPPGAVGEPGL---PGDSGMKGDLGPLGPPGEQGLIGQRGEPGLEG
140 150 160 170 180
770 780 790 800 810 820
mKIAA4 PRGPAGPIGPPGPAGQPGDKGEGGSPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPGQNG
.::.:: : : :.:: :: : : :. : :.:: ::: .: :: :. :
mKIAA1 DHGPVGPDGLKGDRGDPGPDGEHGEKGQEGLKGEDGSPG------PPGITGVPGREGKPG
190 200 210 220 230 240
830 840 850 860 870 880
mKIAA4 EPGAKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQGVKGERGSPGGPGTAGFPGGRG
. : ::.::: : ::. : : : : :: : :::.: .: : :.:: : ..:
mKIAA1 KQGEKGQRGAKGAKGHQGYLGEMGIPGEPGPPGTPGPKGSRGTLGPTGAPGRMG---AQG
250 260 270 280 290 300
890 900 910 920 930 940
mKIAA4 LPGPPGNNGNPGPPGPSGAPGKDGPPGPAGNSGSPGNPGIAGPKGDAGQPGEKGPPGAQG
:: : ::. : :: : :: : : :..:. .: :: :: : :..: : :
mKIAA1 EPGLAGYNGHKGITGPLGPPGPKGEKGDQGEDGKTEGP--PGPPGDRGPVGDRGDRGEPG
310 320 330 340 350
950 960 970 980 990
mKIAA4 PPGSPGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIKGE---SGKPGASGHNGERGPPG
:: :: :. :: : : : :: ::::: :::.: ::: .:::: .: .:.:: :
mKIAA1 DPGYPGQEGVQGLRGEPGQQGQPGHPGPRGRPGPKGSKGEEGPKGKPGKAGPSGRRGTQG
360 370 380 390 400 410
1000 1010 1020 1030 1040 1050
mKIAA4 PQGLPGQPGTAGEPGRDGNPGSDGQPGRDGSPGGKGDRGENGSPG--AP----GAPGHPG
::::: :..:. : .:. :::: ::::: :: .::.:..:.:: .: : :: :
mKIAA1 LQGLPGPRGVVGRQGPEGTAGSDGIPGRDGRPGYQGDQGNDGDPGPVGPAGRRGNPGVAG
420 430 440 450 460 470
1060 1070 1080 1090 1100 1110
mKIAA4 PPGPVGPSGKSGDRGETGPAGPSGAPGPAGARGAPGPQGPRGDKGETGERGSNGIKGHRG
:: :: : .:. : : :: : : :. : :: :: :.::. :. : :. : :
mKIAA1 LPGAQGPPGFKGESGLPGQLGPPGKRGTEGGTGLPGNQGEPGSKGQPGDSGEMGFPGVAG
480 490 500 510 520 530
1120 1130 1140 1150 1160 1170
mKIAA4 FPGNPGPPGSPGAAGHQGAIGSPGPAGPRGPVGPHGPPGKDGTSGHPGPIGPPGPRGNRG
. : ::::. : : :: : :: : .: .:: :: : :: ::: : : ::. :
mKIAA1 LFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIIGP---PGMLGPSGLPGPKGDRGSRGDLG
540 550 560 570 580 590
1180 1190 1200 1210 1220
mKIAA4 ERGSEGSPGHPGQPGPPGPPGAPGPCCGG--GAAA---IAGVGGEKSGGFSPYYGDDPMD
.: .: :: :.::::::: : ::: . . :. .: :.: : . .:
mKIAA1 LQGPRGPPGPRGRPGPPGPPWHPIQFQQDDLGAAFQTWMDAQGAVRSEGYS-YPDQLALD
600 610 620 630 640 650
1230 1240 1250 1260 1270 1280
mKIAA4 FKINTEEIMSSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCK
. ::...:. ... :.:. .: :...:::: :::: :. .. .: :::::: ::.
mKIAA1 ---QGGEIFKTLHYLSNLIQSIKTPLGTKENPARVCRDLMDCEQRMADGTYWVDPNLGCS
660 670 680 690 700 710
1290 1300 1310 1320 1330 1340
mKIAA4 MDAIKVFCNM-ETGETCINASPMTVPRKHWWTDSGAEKKHVWFGESMNGGFQFSYGPPDL
:.:.: ::. . :.::.. :.:. : :: : :
mKIAA1 SDTIEVSCNFTQGGQTCLK--PITA--------SKAE-------------FAVSR-----
720 730 740
1350 1360 1370 1380 1390 1400
mKIAA4 PEDVVDVQLAFLRLLSSRASQNITYHCKNSIAYMD-QASGNVKKSLKLMGSNEGEFKAEG
::. ::.::::...:.:: :: : .... . ......... . : :.: :
mKIAA1 ------VQMNFLHLLSSEGTQHITIHCLNMTVWQEGPGRSSARQAVRFRAWNGQVFEAGG
750 760 770 780 790
1410 1420 1430 1440 1450 1460
mKIAA4 NSKFTYTVLEDGCTKHTGEWSKTVFEYQTRKAMRLPIIDIAPYDIGGPDQEFGVDIGPVC
.: : ::: : :.: .:.: ..:. ..:::... . ... ...::.:
mKIAA1 --QFRPEVSMDGCKVHDGRWHQTLFTFRTQDPQQLPIVSVDNLPPVSSGKQYRLEVGPAC
800 810 820 830 840 850
mKIAA4 FL
::
mKIAA1 FL
>>mFLJ00201 ( 640 res) mpm06260 (640 aa)
initn: 1201 init1: 622 opt: 1560 Z-score: 593.0 bits: 121.1 E(): 6.9e-28
Smith-Waterman score: 1647; 46.599% identity (54.043% ungapped) in 588 aa overlap (171-748:12-528)
150 160 170 180 190 200
mKIAA4 SPGICESCPTGGQNYSPQFDSYDVKSGVGGMGGYPGPAGPPGPPGPPGSSGHPGSPGSPG
. : ::: : ::: :::: : ::.::.
mFLJ00 LEMPLPMLPMDLKGEPGPPGKPGPRGPPGPPGFPGKPGT--
10 20 30
210 220 230 240 250 260
mKIAA4 YQGPPGEPGQAGPAGPPGPPGALGPAGPAGKDGESGRPGRPGERGLPGPPGIKGPAGMPG
: :: :: ::::::: . .: ::: : :. : ::.:: :: :: : .: : ::
mFLJ00 --GKPGVHGQPGPAGPPGF-SRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGPPG
40 50 60 70 80 90
270 280 290 300 310 320
mKIAA4 FPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGAPGPMGPRGAPGERGRPGLPGAAG
::. : :. .:: :: .::::: : :: :: .:.:: : :
mFLJ00 PPGLPGPSGIT----------VPGK------PGAQGAPGPPGFRGEPGPQGEPGPRGDRG
100 110 120 130 140
330 340 350 360 370 380
mKIAA4 ARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGSPGQRGEPGPQGHAG
.:..:. :::: :: :: :: :: :: : ::: :.:: : :: : :
mFLJ00 LKGDNGV----GQPGLPGAPGQAGAPGPPGLPG---PAGL----GKPGLDGIPGAPGDKG
150 160 170 180
390 400 410 420 430
mKIAA4 AQGPPGPPGNNGSPGGKGEMGPAGIPGA--PGLIGARGPPGPAGTNGIPGTRGPSGE--P
.:::: ::. : ::. : :: :. :. :: :. :: ::.:..: :: ::: : :
mFLJ00 DSGPPGVPGSRGEPGAVGPKGPPGVDGVGIPGAAGVPGPQGPVGAKGEPGLRGPPGLIGP
190 200 210 220 230 240
440 450 460 470 480 490
mKIAA4 GKNGAKGEPGARGERGEAGSPGIPGPKGEDGKDGSPGEPGANGLPGAAGERGPSGFRGPA
: :.:: .:.:: .:.::. : .:: :.::.::: : .:: : : :. : :
mFLJ00 VGYGMPGKPGPKGDRGPVGAPGLLGDRGEPGEDGKPGEQGPQGLGG------PPGLPGSA
250 260 270 280 290 300
500 510 520 530 540 550
mKIAA4 GPNGIPGEKGPPGERGGPGPAGPRGVAGEPGRDGTPGGPGIRGMPGSPGGPGNDGKPGPP
: .::..:::: .: ::.:: :: ::::: : :.: . :::: :
mFLJ00 G---LPGRRGPPGSKGEVGPGGP------------PGVPGIRGDQG-PNGLA--GKPGLP
310 320 330 340
560 570 580 590 600 610
mKIAA4 GSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGET
: .: : :::::.::.:.:: : :: : :: :..:. : :: ::: ::.: :
mFLJ00 GERGLPGAHGPPGPTGPKGEPGFTGRPGGPGVAGALGQKGDLGLPGQPGLRGPSGIPGLQ
350 360 370 380 390 400
620 630 640 650 660 670
mKIAA4 GPQGPPGPTGPAGDKGDSGPPGPQGLQGIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGK
:: :: :: .: :: :.: :: ::::: :: :::: : .: ::.::.
mFLJ00 GPAGPIGP---------QGLPG---LKGEPGLPGPPGE-GKVGEPGSAGPTGPPGVPGSP
410 420 430 440 450
680 690 700 710 720 730
mKIAA4 GDSGAPGERGPPGTAGIPGA---RGGAGPPGPEGG-KGPA-GPPGPPG-ASGSPGLQGMP
: .: :: :::: : ::: : :: :.:: .: . : : : . : . .. :
mFLJ00 GLTGPPGPPGPPGPPGAPGALDETGIAGLHLPNGGVEGAVLGKGGKPQFGLGELSAHATP
460 470 480 490 500 510
740 750 760 770 780 790
mKIAA4 GERGGPGSPGPKGEKGEPGGAGADGVPGKDGPRGPAGPIGPPGPAGQPGDKGEGGSPGLP
. . :: : . : :
mFLJ00 AFTAVLTSPFPAS--GMPVRFDRTLYNGHSGYNPATGIFTCPVGGVYYFAYHVHVKGTNV
520 530 540 550 560 570
>>mKIAA4178 ( 1796 res) mtg01289 (1796 aa)
initn: 226 init1: 123 opt: 686 Z-score: 269.8 bits: 62.8 E(): 7e-10
Smith-Waterman score: 886; 27.042% identity (32.476% ungapped) in 1261 aa overlap (75-1187:554-1751)
50 60 70 80 90
mKIAA4 SRDVWKPEPCQICVCDSGSVLCDDIICDEEPLDCPNPEIPFGECCAICPQPS-----TPA
: : : . : :. . : .:.
mKIAA4 APALPPTPTPTPEKEPEEPAQAPPVQAAPSPGVAPVPTLVSGGGCTANSNSSGSFEASPV
530 540 550 560 570 580
100 110 120 130 140 150
mKIAA4 -PVLPDGHGPQGPKGDPGPPGIPGRNGDPGLPGQPGLPGPP----GSPGICESCPTGGQN
: ::. .::. :. : : :. . .: : . :: : : .: : :
mKIAA4 EPQLPSKEGPEPPEEVPPPTTPPAPKMEPKGDGVGSTRQPPSQGLGYPKYQKSLPPRFQR
590 600 610 620 630 640
160 170 180 190 200 210
mKIAA4 YSPQFDSYDVKSGVGGMGGYPGPAGP-PGPPGPPGSSGHPGSPGS-PGYQGPPGEPGQAG
. . . .. . : : : : ::.:: .: . :. :. :.:: :
mKIAA4 QQQEQLLKQQQQQQQWQQQQQGTAPPAPVPPSPP----QPVTLGAVPAPQAPPPPPKALY
650 660 670 680 690
220 230 240 250 260
mKIAA4 PAG----PPGPPGALGP---AGPAGKDGE--SGRPGRPGERGLPGPPGIKGPAGMPGFPG
:.. :: :: . : : : . .::: : . :::.. :.:. :
mKIAA4 PGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRP--PLDFY---PPGVH-PSGL--VPR
700 710 720 730 740 750
270 280 290 300 310
mKIAA4 MKGHRGFDGRNGEKGETGAPGLKGENGLP---------GDNGAPGPMGPRGAPGERGRPG
.. : : ..: : :: : : : : :: . : :: .
mKIAA4 ERSDSG--GSSSEPFERHAPPLLRERGTPPVDPKLAWVGDVFTTTPTDPRPLTS------
760 770 780 790 800
320 330 340 350 360 370
mKIAA4 LPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGS--P-GSNGSPGQRG
: .: .. . :. : :: :: :..:: : .: :: : : .. :: :
mKIAA4 -PLRQAADEEEKSMRSETPPVPPPPPYLANYPGFP-ENGTPGPPISRFPLEESAPPGPRP
810 820 830 840 850 860
380 390 400 410
mKIAA4 EPGPQGH---AGAQGPPG--------PPGNNGSPGGK----GEMGPAGIPGAPGLIGAR-
: : :. : :.:: :: .: .:. : .:: : . .:
mKIAA4 LPWPPGNDEAAKMQAPPPKKEPSKEEPPQLSGPEAGRKPARGGQGPPP-PRRENRTETRW
870 880 890 900 910 920
420 430 440 450 460
mKIAA4 GP-PG------PAGTNGIPGTR-GPSGEPGKNGAKGE-PGARGERGEAGSPGIPGP---K
:: :: : :.: : :: .: : : :.:. .: .: : :
mKIAA4 GPRPGSCRRGIPPEEPGVPPRRAGPIKKPPPPVKVEELPPKSLEQGDE-TPKVPKPDALK
930 940 950 960 970
470 480 490
mKIAA4 GEDGKDGSPGE--PGANGLPGAAGER-------GPS---------------GFRGPAGPN
:: : : : ::.: :. .: ::. :::: :
mKIAA4 TAKGKVG-PKETPPGGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGR
980 990 1000 1010 1020 1030
500 510 520 530 540
mKIAA4 GIPGE----------KGPPGERGGPG----PAGPRG-VAGEPGRDGTPGG--PGIRGMPG
: .. .: :. :: : :..::: .:.: .:. : : . :
mKIAA4 GRGARSREFRSYREFRGDDGRGGGSGGTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRG
1040 1050 1060 1070 1080 1090
550 560 570 580
mKIAA4 SPGGP-------GNDGKPGPPGSQGESGR-P-GPPGPSGPRGQPGVMGFPGPKGND----
: : . . : .:: ..: :. : .:: :..: .:. : .:.
mKIAA4 SETGSETHESDLAPSDKEAPPPKEGVLGQVPLAPPQPGAP-PSPAPARFSTARGGRVFTP
1100 1110 1120 1130 1140 1150
590 600 610 620 630 640
mKIAA4 -GAPGKNGERGGPGGPGLPG--PAGKN--GETGPQGPPGPTG-PAGDKGDSGPPGPQGLQ
:.:.. :. :: : : : .:. . : :: :. : .: ::: .:..
mKIAA4 RGVPSRRGRGGGRPPPVCSGWSPPAKSLVPKKPPTGPLPPSKEPLKEKLISGPLSPMSRA
1160 1170 1180 1190 1200 1210
650 660 670 680 690 700
mKIAA4 GIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGKGDSGAPGERGPPGTAGIPGARGGAGPP
: :.: :: . . : . : . . :: : :. .:. :
mKIAA4 GNMGVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGADGKP--PSLTLAASTP
1220 1230 1240 1250 1260 1270
710 720 730 740 750 760
mKIAA4 GPEGGKGPAGPPGPP--GASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDG
::: : : :: :. :: :... ..... :. : .. ..: . . :
mKIAA4 GPEETLTAATVPPPPRRTAAKSPDLSNQNSDQAN--------EEWETASESSDFASERRG
1280 1290 1300 1310 1320
770 780 790 800 810
mKIAA4 PR-GPAGPIGPPGPAGQPGDKGEGGSPGLPGIAGPRGGPGERGEHGPPG--PAGFPGAPG
. : . . .: :: .. :..::. ... :: ..:.. . ::
mKIAA4 DKETPPAALMTSKAVGTPGANAGGAGPGISAMS--RGDLSQRAKDLSKRSFSSQRPGMDR
1330 1340 1350 1360 1370 1380
820 830 840 850 860 870
mKIAA4 QNGEPGAKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQGVKGERGSPGGPGTAGFPG
:: .::. :. :. : .. :: ::.: :: :: .:.. : .: . . :
mKIAA4 QNRRPGTGGKTGSGGGSSGGGGAGPGGRTG-------PG----RGDKRSWPSPKNRSRPP
1390 1400 1410 1420 1430
880 890 900 910 920 930
mKIAA4 GRGLPGPPGNNGNPGPPGPSGAPGKDG--PPGPAGNSGSPGNPGIAGPKGDAGQPG----
. ::: : ::. :.. : .::: . . .. ... .:.. ::
mKIAA4 EER---PPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQ--LSSRQGNVTAPGGHPR
1440 1450 1460 1470 1480
940 950 960 970 980 990
mKIAA4 -EKGPPGA-QGPPGSPGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGH
. ::: : :: : : .. .... : . :::. ..: .: : :.
mKIAA4 PKPGPPQAPQGSSPRP-PTRYDPPRASSAISSDPHFE----EPGPM-VRGVGGTPRDSAG
1490 1500 1510 1520 1530 1540
1000 1010 1020 1030 1040 1050
mKIAA4 NGERGPPGPQGLPGQPGTAGEPGRDGNPGSDGQPGRDGSPGGKGDRGENGSPGAPGAPGH
. : . : .: : . :.: .. ..: : . :. . :. . :
mKIAA4 VNPFPPKRRERPPRKPELLQE---ETVPASHSSGFLGSKPEVPGPQEESRDSGTEALTPH
1550 1560 1570 1580 1590 1600
1060 1070 1080 1090 1100
mKIAA4 PGPPGPVGPSGKSGDRGETGPAGPSGAP--GPAGARGAPGPQGP--RGDK----GETGER
.. : :: . : : .: ::.. . . .: ::. : ..:
mKIAA4 IWNRLHTATSRKSYQPGSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQR
1610 1620 1630 1640 1650 1660
1110 1120 1130 1140 1150
mKIAA4 GS--NGIKGH-RGFPGNPGPPGSPGAAGHQGAIGSPGPAGPRG-PVGPHGPPGKDGTSGH
.: .:.:: .: : :: :. .:. ..: :: :: : . : :. .
mKIAA4 SSPDGGLKGSAEGPPKRPGGPSPLNAVPGESASGSEPSEPPRRRPPASHEGERKELPREQ
1670 1680 1690 1700 1710 1720
1160 1170 1180 1190 1200 1210
mKIAA4 PGPIGPPGP-RGNRGERGSEGSPGHPGQ-PGPPGPPGAPGPCCGGGAAAIAGVGGEKSGG
: : :: : :..: .:: : .: .:.. ::
mKIAA4 PLPPGPIGTERSQRTDRGPEPGPLRPAHRPGSQVEFGTTNKDSDLCLVVGDTLKGEKELV
1730 1740 1750 1760 1770 1780
1220 1230 1240 1250 1260 1270
mKIAA4 FSPYYGDDPMDFKINTEEIMSSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSG
mKIAA4 ASARGRSHIQRLGAAP
1790
>>mKIAA0824 ( 1641 res) mth01748 (1641 aa)
initn: 307 init1: 126 opt: 421 Z-score: 174.0 bits: 45.0 E(): 0.00015
Smith-Waterman score: 492; 30.782% identity (35.630% ungapped) in 588 aa overlap (445-997:800-1342)
420 430 440 450 460 470
mKIAA4 RGPPGPAGTNGIPGTRGPSGEPGKNGAKGEPGARGERGEAGSPGIPGPKGEDGKDGSPGE
: : . .. .: . :: .. :
mKIAA0 FLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDGPASR-----FAGL
770 780 790 800 810 820
480 490 500 510 520 530
mKIAA4 PGANGLPGAAGERGPSGFRGPAGPNGIPGEKGPPGE-RGGPGPAGPRGVAGEPGRDGTPG
. : . : .: : : ::. :. . :: ::. .:: . : : :::
mKIAA0 DTNQRLTALAEDR-PL-FDGPGRPSVT--RDGPAKMIFEGPNKLSPR-IDGPP----TPG
830 840 850 860 870
540 550 560 570 580 590
mKIAA4 GPGIRGMPGSPGGPGNDGKPGPPGSQGESGRPGP-PGPSGPRGQPGVMGFPGPKGNDGAP
. . : ::. :: : :: :. : .: : :: :: : : . : :: :. :.
mKIAA0 SLRFDGSPGQMGGGGPMRFEGPQGQLG-GGCPLRFEGPPGPVGTP--LRFEGPIGQGGGG
880 890 900 910 920 930
600 610 620 630 640 650
mKIAA4 GKNGERGGPGGPGLPGPAGKNGETGPQGPPG-PTGPAGDKGDSGPPGPQGLQGIPGTGGP
: : :.:.: :..: .:: : :.: .: : : ::. . : :
mKIAA0 GFRFE----GSPSLRFE-GSTGGLRFEGPGGQPVGGLRFEGHRGQP-VGGLR-FEGPHGQ
940 950 960 970 980
660 670 680 690 700
mKIAA4 PGENGKPGEPGPKGE-VGAPGAPGGKGDSGAPGE-RGPPGTAGIPGARGGAGPPGPEGGK
: :. .:.:. ::. ::.: ::: . :: : ::. :: :: .
mKIAA0 P--VGSLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQ---PGGGGGIRFEGPLLQQ
990 1000 1010 1020 1030 1040
710 720 730 740 750 760
mKIAA4 GPAGP--PGPPGASGSPGLQGMPGERGGPGSPGPKGEKGEPG-GAGADG--VPGKDGPR-
: .: :: : : . ::. . :. :. .: .:.:: : .: : : :
mKIAA0 G-VGMRFEGPHGQSVA-GLR-FEGHNQLGGNLRFEGPHGQPGVGIRFEGPIVQQGGGMRF
1050 1060 1070 1080 1090
770 780 790 800
mKIAA4 -GP--AGPIGPPGPAGQPGDKGEG-------GSPG----LPGIAGPRGGPGERGEH-GPP
:: .: . :: :: : . :: :.:: :: . : .: :: : :. : :
mKIAA0 EGPVPGGGLRIEGPLGQGGPRFEGCHSLRFDGQPGQPSLLPRFDGLHGQPGPRFERTGQP
1100 1110 1120 1130 1140 1150
810 820 830 840 850 860
mKIAA4 GPAGFPGAPGQNGEPGAKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQGVKGER-GS
:: : : :::. .: . .: : :: ... : :..: : .
mKIAA0 GPQRFDGPPGQQVQP-----------RFDGVPQRFDGPQHQQASRFDI-PLGLQGTRFDN
1160 1170 1180 1190 1200
870 880 890 900 910 920
mKIAA4 PGGPGTAGFPGGRGLPGPPGNNGNPGPPGPSGAPGK---DGPPGPAGNSG-SPGNPGIAG
. .: . ::::. : : . . : : :: :. .::: .. .
mKIAA0 HPSQRIESFNHSGPYNDPPGNTFNVPSQGLQFQRHEQIFDTPQGPNFNGPHGPGNQNFPN
1210 1220 1230 1240 1250 1260
930 940 950 960 970
mKIAA4 PKGDA-GQP-GEKGPPGAQ-GPPGS-PGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIK
: . : :. ::. ..: : :. : :...... ... . ..: :. : : .
mKIAA0 PINRASGHYFDEKNLQSSQFGNFGNLPTPISVGNIQASQQVLTGVAQPVAFGQ-GQQFLP
1270 1280 1290 1300 1310 1320
980 990 1000 1010 1020 1030
mKIAA4 GESGKPGASGHNGERGPPGPQGLPGQPGTAGEPGRDGNPGSDGQPGRDGSPGGKGDRGEN
. .::: .: : :
mKIAA0 VHPQNPGAFIQNPSGGLPKAYPDNHLSQVDVNELFSKLLKTGILKLSQPDSATAQVTEAV
1330 1340 1350 1360 1370 1380
>>mKIAA0689 ( 643 res) mfj03025 (643 aa)
initn: 105 init1: 105 opt: 373 Z-score: 161.8 bits: 41.4 E(): 0.00072
Smith-Waterman score: 475; 34.928% identity (41.595% ungapped) in 418 aa overlap (333-725:217-592)
310 320 330 340 350
mKIAA4 PRGAPGERGRPGLPGAAGARGNDGARGSDGQP--GP-PGPPGTAGFPGSPGAKGEVGPAG
:: :: :: :: .: ::.:: :::
mKIAA0 QVVMRIMDPEIALKILHRKIHVTPLIPGKSQPVSGPGPGGPGPSG-PGGPGP----GPAP
190 200 210 220 230 240
360 370 380 390 400 410
mKIAA4 S--PGSNGSPGQRGEPGPQGHAGAQGP--PGPPGNNGS-PGGKGEMGP--AGIPGAPGLI
. :: : .:.. :.:: . . : :: . : :: :: :..:: ::
mKIAA0 GLCPGPNVMLNQQNPPAPQPQHLPRRPVKDIPPLMQTSIQGGIPAPGPIPAAVPG-PG-P
250 260 270 280 290
420 430 440 450 460
mKIAA4 GARGPPGPAGTN-GIPGTRGPSGEPGKNGAK--GEPGARGERGEAGSPGIPGPKGEDGKD
:. : : . :.: . :: : . : ..: :: : ::: :.: :
mKIAA0 GSLTPGGAMQPQVGMP-VVGPV--PLERGQMQISDPRPPMPRGPMPSGGIP-PRGLLGD-
300 310 320 330 340 350
470 480 490 500 510 520
mKIAA4 GSPGEPGANGLPGAAGERGPSGFRGPA--GPNGIPGE--KGPPGE--RGGPGPAGPRGVA
.:..: .. : ...:: : :. :: :: :. .:: .. :::: : :: .
mKIAA0 -APNDPRGGTLLSVTGEVEPRGYMGPPHQGPPMHHGHDNRGPASHDMRGGPLAADPRMLI
360 370 380 390 400 410
530 540 550 560 570 580
mKIAA4 GEPGRDGTPGGPGI--RGMPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMG
::: :: : ::.: ::. : :.: :: :::. :
mKIAA0 GEPR------GPMIDQRGLP-------MDGRGGRE-SRGMETRPMETEVLEPRGMERRME
420 430 440 450
590 600 610 620 630 640
mKIAA4 FPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGETGPQGPPGPTGPAGDKGDSGPPGPQG
. . . : ... : ::: :. :: .: : ::: :: . : .:: ::.
mKIAA0 TCAME-TRGMDARGLEMRGPG-PSSRGPM--TG--GIQGP-GPI----NMGAGGPQGPRQ
460 470 480 490 500
650 660 670 680 690
mKIAA4 LQGIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGKGDSGAP--GERGPPGTAGIPGA--R
. .: :.:.: : : : : :: :: .: : .: ::. :: .
mKIAA0 VPNIAGVGNPGGTMQGAGIQGG-GMQGAGMQGGGMQGAGMQGGGMQGAGMQAGMQGASMQ
510 520 530 540 550 560
700 710 720 730 740 750
mKIAA4 GGAGPPGPEGGKGPAGPPGPPGASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVP
:: : .:.. .: : : .: :::
mKIAA0 GGMQGAGMQGASKQGG--GQP-SSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPE
570 580 590 600 610 620
>>mKIAA1236 ( 1309 res) mpm04158 (1309 aa)
initn: 84 init1: 84 opt: 372 Z-score: 157.5 bits: 41.6 E(): 0.0013
Smith-Waterman score: 441; 25.577% identity (31.322% ungapped) in 954 aa overlap (107-968:279-1149)
80 90 100 110 120 130
mKIAA4 DCPNPEIPFGECCAICPQPSTPAPVLPDGHGPQGPKGDPGPPGIPGRNG-DPGLPGQPGL
:::: :. : . :.:.: :.:: .
mKIAA1 GPRDADHFRCSTFAELQERLECIDGSEAFPGPQG--GSDGAQASPARGGRKPSLP--EAT
250 260 270 280 290 300
140 150 160 170 180 190
mKIAA4 PGPPG-SPGICESCPTGGQNYSPQFDSYD-VKSGVGGMGGYPGPAGPPGPPGPPGSSGHP
:. . .: . ::: :. ... . .. : :.:. . : : ::. .::
mKIAA1 PSRKAVAPTVVTSCPRGSPGHDTHRSASDPSKTGTQSEQRVDGSR--PEPPASDKTSGGG
310 320 330 340 350 360
200 210 220 230 240 250
mKIAA4 GSPGSPGYQGPPGEPGQAGPAGPPGPPGALGPAGPAGKDGESGRP--GRPGERGLPGPPG
: :. :: : : : : ::. : :. : : :. .:: :
mKIAA1 GRRPLPSPAPPP--PRQPEAQGIPKEPGG------EGTDSVLRTPPVGMSGQAALP--PL
370 380 390 400 410
260 270 280 290 300
mKIAA4 IKGPAGMPGFPGMKGHRGFDGRNGEKGETGAP-GLKGENGL--------P--GDNGAPGP
.. : . :. .:.. : : :.::. : : : :: :
mKIAA1 LSDSAYLS--PSARGRHLERGLLTTTVTLQQPVELNGEDELVFTVVEELPLGGLAGATRP
420 430 440 450 460 470
310 320 330 340
mKIAA4 MGPRGAPGERGRPGLPGAAGARG-------ND-----GARGSDGQPGPPG--PPGTAGFP
. . .. . .: :.:.: :: .. :.: :: :: : :::
mKIAA1 SSLASMSSDCSLQAL--ASGSRPVSIISSINDEFDAYTSQMSEG-PGDPGEFPEGTAWAG
480 490 500 510 520
350 360 370 380 390 400
mKIAA4 GSPGAKGEVGPAGSP-GSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGSPGGKGEMGPA--
.::... .: : : : .. : : .. . :::: . .::.. : . .
mKIAA1 SSPASS--IGSWLSDVGVCLSESRGPTPQPPFSPNSAAGPGPP-EFPTPGSSLEESKVRS
530 540 550 560 570 580
410 420 430 440 450
mKIAA4 ---GIPGAPGLIGARG-PPGPAGTNGIPGTRGPSGEPGKNGAKGEPGARGERGEAGSPGI
: : :: .::. :: : . :. .::. :: ::. . :. :
mKIAA1 SECGRPDNPG--SARSLHPGEA----VATTQT---QPGR-----EPWARSPHEVASVQTI
590 600 610 620 630
460 470 480 490 500 510
mKIAA4 PGPKGEDGKDGSPGEPGANGLPGAAGERGPSGFRGPAGPNGIPGEKGPPGERGGPGPAGP
... : .: ... .:.. :: ::: .:.:. . : :.
mKIAA1 --------HSSLPRKPRTTS---TASRARPS--RGPYSPGGL--FEDPWLLRAED--CDT
640 650 660 670
520 530 540 550 560
mKIAA4 RGVAGEPGR--DGTPGGPGI-----------RGMPGSPGGPGNDGKPG-----PPGSQGE
: .:. :: . :::.: . : . : . . .: :: .:
mKIAA1 RQIAST-GRAPSPTPGSPRLPETQMMLACAQRVVDGCEVASRMSRRPEAVARIPPLRRGA
680 690 700 710 720 730
570 580 590 600 610
mKIAA4 S--GRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGETGPQ
. : : . : .:. . :...:. . .: : .: :.:
mKIAA1 TTLGVTTPAASCGDAPAEAVVHSGSLKNTSGSK----KSVSPKGAFFPRPSGA-------
740 750 760 770 780
620 630 640 650 660 670
mKIAA4 GPPGPTGPAGDKGDSGPPGPQGLQGIPGTGGPPGENGKP-GEPGPKGEVGAPGAPG----
:::.: .. .: : :. .:.: . :. ..:. ... ..: : .
mKIAA1 GPPAPPVRKSSLEQSTALTPTQALGLTRAGAPSAFRGEEEARPSGRSDSSVPKATSSLKA
790 800 810 820 830 840
680 690 700 710 720
mKIAA4 --GKGD-----SGAPG-ERGPPGTAGIPGARGGAG-PPG--PEGGKGPAGPP-GP-PGAS
:: : :: . :: . : .: .: :: :. : :.:: :: :.
mKIAA1 RAGKMDAPYRPSGHMSLERCEGLAHGSSKVRDVVGRPPRAVPRLGVPSASPPLGPAPACR
850 860 870 880 890 900
730 740 750 760 770
mKIAA4 GSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDGPRGP-AGPIGP----PGPAG
.::. .:. . . : . : ::.. :. . : :.: : : :: :: . ::: .
mKIAA1 NSPA-KGVGATK--PPAGGAKGRNLGPSTSRALGAPVK--PLGPVAGKTAAGGAVPGPRA
910 920 930 940 950
780 790 800 810 820 830
mKIAA4 QP-GDKGEGGSPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPGQNGEPGAKGERGAPGEK
: . : :.. : : : . . :. :. . :.:...: .. . . ...
mKIAA1 APRAVPGIGAKAGRGTIMGTK--QAFRAAHSRVHELAASGSPSRGGLSWGSTDSDSGNDS
960 970 980 990 1000 1010
840 850 860 870 880
mKIAA4 G-----EGGPPGPAGPTGSSGPAGPPGPQGVKGERGSPGGPGTAG-FPGGRGLPG----P
: : : .:: :. : ..: :: .. .:: .. .: .: . : .
mKIAA1 GVNLAEERQPSSPALPSPYSKVTAPRRPQRYSSGHGSDNSSVLSGELPPAMGRTALFYHS
1020 1030 1040 1050 1060 1070
890 900 910 920 930 940
mKIAA4 PGNNGNPGPPGPSGAPGK-DGPPGPAGNSGSPGNPGIAGPKGDAGQPGEKGPPGAQGPPG
:..: . : : :. .. : ..::. . : .. . . .: : :
mKIAA1 GGSSGYESMIRDSEATGSASSAPDSMSESGTAS----LGARSRSLKSPKKRATGLQRRRL
1080 1090 1100 1110 1120 1130
950 960 970 980 990 1000
mKIAA4 SPGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNGERGPPGPQGLPG
:.:: :. : . :..::
mKIAA1 IPAPLPDAAALGRK-----PSLPGQWVDLPPPLAGSLKEPFEIKVYEIDDVERLQRHRLP
1140 1150 1160 1170 1180
>>mKIAA1139 ( 1224 res) mpg00286 (1224 aa)
initn: 147 init1: 106 opt: 360 Z-score: 153.5 bits: 40.8 E(): 0.0021
Smith-Waterman score: 431; 28.172% identity (33.187% ungapped) in 536 aa overlap (422-900:655-1166)
400 410 420 430 440 450
mKIAA4 GSPGGKGEMGPAGIPGAPGLIGARGPPGPAGTNGIPGTRGPSGEPGKNGAKGE-PGARGE
: .: :::: .. .:: : . :
mKIAA1 VNKLGHQKKLMLGVKRLAELRRGLLHGEALGEGGRRMTRGPELMAIEGLENGEGPTTAGP
630 640 650 660 670 680
460 470 480 490 500
mKIAA4 R-----GEAGSPGIPGPKGEDGKDGSPGEPGANGLPGAAGERGPSGFRGPAGPNGIP--G
: : :: . . . :.. : :. . . : :. .. .. : : :
mKIAA1 RLLTFQGSELSPELQAAMAGGGSEPLPLPPARSPSQESIGARSRGSGHSQEQPVPQPSVG
690 700 710 720 730 740
510 520 530 540 550
mKIAA4 EKGPPGERGGP-GPAGPRGVAGE-PGRDGTP---GGPGIRGMPGSPGGPGNDGKPGPPGS
. . : ::. : : : . . ::. .: : ...:.::. :: :: : .
mKIAA1 DPSAPQERNLPEGTERPSKLCSPLPGQGPAPYVFMCP--QNLPSSPA-PGPP--PGVPRA
750 760 770 780 790
560 570 580 590 600 610
mKIAA4 QGE-SGRPG-PPGPSGPRGQPGVMGFPGPKGNDGAPGK-NGERGGPGGPGLPGPA-----
. .: :. :: : :. . .. ::: : :. .:: :: : .: . :
mKIAA1 FSYLAGSPAAPPDPPRPKRRSHSLSRPGP-----AEGEAEGEAEGPVGSALGSYATLTRR
800 810 820 830 840 850
620 630 640 650
mKIAA4 -GKN--GETGPQGPPGPTGP--------AGDKGDSGPPGPQGLQGIPGTGGPPGENG---
:.. ..:.:. : : : :: :: :. :... :. ::. .:
mKIAA1 PGRSTLARTSPSLTPTRGTPRSQSFALRARRKGPPPPP-PKRLSSVSGSTEPPSLDGTSG
860 870 880 890 900 910
660 670 680 690 700
mKIAA4 -KPGEPGPKGE-VGAPGAPGGKGDSGAPGERGP-------PGTAGIPGARGGAGPPGPEG
: : ::. . .. : .:. . .:: :: :: : : .::..: : .
mKIAA1 PKEGATGPRRRTLSEPTGPSESPGPSAP--TGPVSDTEEEPGPEGTPPSRGSSGEGLPFA
920 930 940 950 960 970
710 720 730 740 750
mKIAA4 GKG---------PAGPPGPPGASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAG--ADGV
.: ::::: : . :::. : . . :: .. :: .. : ::
mKIAA1 EEGNLTIKQRPKPAGPP-PRETPVPPGLDFNLTE-SDTVKRRPKCKEREPLQTALLAFGV
980 990 1000 1010 1020
760 770 780 790 800 810
mKIAA4 PGKDGPRGPAGPIGPPGPAGQPGDKGEGGSPGLPGIAGPRGGPGERGEHGPPGPAGFPGA
:.: : ::..:.. .: :. ... . . :.. : : . . . ::
mKIAA1 VGSDTP-GPSNPLSTQAPCDPPSASSNPPQRSEPSVL-PSQGTSASSLSSVTQS---PGH
1030 1040 1050 1060 1070 1080
820 830 840 850 860 870
mKIAA4 PGQNGEPGAKGERGA-PGEKGEGGPPGP-AGPTGSSGPAGPPGPQGVKGERGSPGGPGTA
:: .. :. . :. :. . : ::.: :. : . : : .: . . .:: :
mKIAA1 PGPSAGPALANSTGSKPNVETE--PPAPPAALLKVPGAGTAPKPVSVACTQLAFSGPKLA
1090 1100 1110 1120 1130 1140
880 890 900 910 920 930
mKIAA4 GFPGGRGLPGPPGNNGNPGPPGPSGAPGKDGPPGPAGNSGSPGNPGIAGPKGDAGQPGEK
: : : :: : :: :: :
mKIAA1 PRLGPR--PVPPPRPENTGPVCPSRAQQRLEQTSSSLEAALRAAEKSIGTEERDGPTGTS
1150 1160 1170 1180 1190 1200
>>mKIAA1983 ( 426 res) mbp99003 (426 aa)
initn: 738 init1: 230 opt: 326 Z-score: 147.0 bits: 38.0 E(): 0.0048
Smith-Waterman score: 364; 36.866% identity (47.619% ungapped) in 217 aa overlap (57-261:178-357)
30 40 50 60 70 80
mKIAA4 QQSNVDELGCSHLGQSYESRDVWKPEPCQICVCDSGSVLCDDI-IC---DEEPLDCPNPE
: : : .: :: : :. : : . :
mKIAA1 RPYCLDIDECATSNTTLCAHICINTMGSYHCECREGYILEDDGRTCTRGDKYPNDTGHEE
150 160 170 180 190 200
90 100 110 120 130
mKIAA4 -----IPFGECCAICPQPST-PAPVLPDGHGPQGPKGDPGPPGIPGR--NGDPGLPGQPG
. : ::: : . : :: . : :. . :. ::: : ..
mKIAA1 KSENEVKAGTCCATCKEFSQMKQTVL---QLKQKMALLPNNAAELGKYVNGDKVLASNAY
210 220 230 240 250 260
140 150 160 170 180 190
mKIAA4 LPGPPGSPGICESCPTGGQNYSPQFDSYDVKSGVGGMGGYPGPAGPPGPPGPPGSSGHPG
:::::: :: :: :::: ::: :: : ::
mKIAA1 LPGPPGLPG--------GQ-------------------------GPPGSPGPKGSPGFPG
270 280 290
200 210 220 230 240 250
mKIAA4 SPGSPGYQGPPGEPGQAGPAGPPGPPGALGPAGPAGKDGESGRPGRPGERGLPGPPGIKG
:: :: :: : : ::. : : ::.: : :: : :::: ::::: :
mKIAA1 MPGPPGQPGPRGSMGPMGPS-PDLSHIKQGRRGPVGPPGAPGRHGSKGERGAPGPPGSPG
300 310 320 330 340 350
260 270 280 290 300 310
mKIAA4 PAGMPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGAPGPMGPRGAPGERGRPG
: : :
mKIAA1 PPGSFDFLLLVLADIRNDIAELQEKVFGHRTHSSAEDFPLPQEFSSYPETLDFGSGDDYS
360 370 380 390 400 410
1467 residues in 1 query sequences
1767550 residues in 2168 library sequences
Scomplib [34t11]
start: Mon Mar 27 11:05:53 2006 done: Mon Mar 27 11:05:55 2006
Scan time: 1.300 Display time: 0.680
Function used was FASTA [version 3.4t11 Apr 17, 2002]