FASTA searches a protein or DNA sequence data bank version 3.4t11 Apr 17, 2002 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 ../query/mKIAA1420.ptfa, 907 aa vs ./tmplib.26680 library 1768110 residues in 2168 sequences Expectation_n fit: rho(ln(x))= 5.1722+/-0.00543; mu= 17.2885+/- 0.363 mean_var=130.9190+/-30.427, 0's: 0 Z-trim: 16 B-trim: 29 in 1/35 Lambda= 0.1121 FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2168) mKIAA1090 ( 857 res) mph00524 ( 857) 662 119 2.5e-27 mKIAA4065 ( 779 res) mpj03374 ( 779) 340 67 1.1e-11 mKIAA0388 ( 758 res) mbh00510 ( 758) 329 65 3.8e-11 mKIAA1876 ( 348 res) mpj00624 ( 348) 317 63 9.3e-11 mKIAA1076 ( 855 res) mbh01320 ( 855) 302 61 8.4e-10 mKIAA0304 ( 1744 res) mbg06324 (1744) 289 59 5.5e-09 mKIAA0339 ( 822 res) mph02448 ( 822) 283 58 6.9e-09 mKIAA1506 ( 1520 res) mbg19167 (1520) 260 54 1.3e-07 mKIAA1757 ( 1450 res) mbg10960 (1450) 236 50 1.9e-06 mKIAA0067 ( 1162 res) mbg05662 (1162) 204 45 5.9e-05 mKIAA4191 ( 931 res) msh25333 ( 931) 165 39 0.0041 mKIAA0333 ( 1201 res) mbg16015 (1201) 165 39 0.0048 >>mKIAA1090 ( 857 res) mph00524 (857 aa) initn: 414 init1: 368 opt: 662 Z-score: 582.9 bits: 119.0 E(): 2.5e-27 Smith-Waterman score: 662; 39.382% identity (41.129% ungapped) in 259 aa overlap (6-258:478-731) 10 20 30 mKIAA1 HNQLYKKPDVPLYKKIRSNV-YVDVKPLSG--YEA .:: : ::.:. : : :. .. : mKIAA1 RVFKNALQEAEARFNEVKLQREARETQESERKP--PPYKHIKVNKPYGKVQIYTADISEI 450 460 470 480 490 500 40 50 60 70 80 90 mKIAA1 TTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAE :::: : :.. : ..:::::.. :: :..:: :: : :: . .... . . .... mKIAA1 PKCNCK-PTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPET-KIIKTD 510 520 530 540 550 560 100 110 120 130 140 150 mKIAA1 EKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH-YCLNLDSGMVIDSY ::::. .:. .. :.:. ::.::...:.: :. ..: : : :..:. .::. mKIAA1 GKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAG 570 580 590 600 610 620 160 170 180 190 200 210 mKIAA1 RMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQL :: .::.::::.:::: ::.::: :.::.:. :.:::::::..::. .. :: . mKIAA1 PKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKT-V 630 640 650 660 670 680 220 230 240 250 260 mKIAA1 CKCGFEKCRGIIGGKSQRMNGLPSH-KGSQSSS-THRKSARAKEKRKSKHKLKKRKGHPS :.:: .: :..: . . .: :. ::..... :.:. :... ::.:. mKIAA1 CRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQ 690 700 710 720 730 740 270 280 290 300 310 320 mKIAA1 EEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIHQKQEEVKHTRDIHSA mKIAA1 LVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDG 750 760 770 780 790 800 >>mKIAA4065 ( 779 res) mpj03374 (779 aa) initn: 335 init1: 197 opt: 340 Z-score: 301.9 bits: 66.9 E(): 1.1e-11 Smith-Waterman score: 348; 31.915% identity (34.286% ungapped) in 188 aa overlap (32-208:583-768) 10 20 30 40 50 60 mKIAA1 NQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCGD-DCLNRMIFAE .. :. . : . :. .: . : mKIAA4 YQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRE 560 570 580 590 600 610 70 80 90 100 110 mKIAA1 CSPNTC-PCGE---------QCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFI :.:. : :: .: : ::: . : .. :::: :.:.. ..:: mKIAA4 CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLA-PSDVAGWGIFIKDPVQKNEFI 620 630 640 650 660 670 120 130 140 150 160 170 mKIAA1 IEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEM :: ::..:..: .: . : .. . .::.. .:.:. : ::. :: ::: .::: mKIAA4 SEYCGEIISQDE-ADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYA 680 690 700 710 720 730 180 190 200 210 220 230 mKIAA1 QKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRM . ::: .:::..: . . .: :: .:: . . .. : mKIAA4 KVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP 740 750 760 770 240 250 260 270 280 290 mKIAA1 NGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKP >>mKIAA0388 ( 758 res) mbh00510 (758 aa) initn: 378 init1: 200 opt: 329 Z-score: 292.5 bits: 65.1 E(): 3.8e-11 Smith-Waterman score: 339; 33.333% identity (37.427% ungapped) in 192 aa overlap (35-208:559-747) 10 20 30 40 50 mKIAA1 YKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTR-KGC-------GDDCLNRM :.:. :: ..: :: .: . mKIAA0 VYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCS-PDCQNRFPGCRCKTQCNTKQCPCYL 530 540 550 560 570 580 60 70 80 90 100 mKIAA1 IFAECSPNTC-PCGEQ---------CCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKA ::.:. : :: . : : ::: . : .. ::: :: .. mKIAA0 AVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLA-PSDVAGWGTFIKESVQK 590 600 610 620 630 640 110 120 130 140 150 160 mKIAA1 GQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDP ..:: :: ::..:..: .: . : .. . . .::.. .:.:. : ::. :: ::: .: mKIAA0 NEFISEYCGELISQDE-ADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNP 650 660 670 680 690 700 170 180 190 200 210 220 mKIAA1 NCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGK :: . ::: .:::..: . . :: :: .:: . . .. : mKIAA0 NCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVF 710 720 730 740 750 230 240 250 260 270 280 mKIAA1 SQRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQL >>mKIAA1876 ( 348 res) mpj00624 (348 aa) initn: 313 init1: 105 opt: 317 Z-score: 285.5 bits: 62.7 E(): 9.3e-11 Smith-Waterman score: 317; 30.693% identity (34.831% ungapped) in 202 aa overlap (56-244:141-331) 30 40 50 60 70 80 mKIAA1 PLSGYEATTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQC .:: ::. ..: : ..: :. .: .. mKIAA1 STCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIF-ECN-HACSCWRNCRNRVVQNGLRAR- 120 130 140 150 160 90 100 110 120 130 140 mKIAA1 LERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDS- :. .:... :::.:. . . : :. ::.::..:..: : . : : ..::. mKIAA1 LQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVR-------EEDSYLFDLDNK 170 180 190 200 210 220 150 160 170 180 190 mKIAA1 -GMV--IDSYRMGNEARFINHSCDPN-----CEMQKWSVNGVYRIGLYALKDMPAGTELT : : ::. .:: .::::: :.:: :.. .. ::.... . . :: .: mKIAA1 DGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLR-FPRIAFFSTRLIQAGEQLG 230 240 250 260 270 200 210 220 230 240 250 mKIAA1 YDYNFHSFNVEKQQL-CKCGFEKCRGIIGGKSQRMNGL---PSHKGSQSSSTHRKSARAK .::. . ..:. . . :.:: ::: .. .::. . :...: ..:. mKIAA1 FDYGERFWDVKGKLFSCRCGSSKCRHSSAALAQRQASAAQEPQENGLPDTSSAAAADPPL 280 290 300 310 320 330 260 270 280 290 300 310 mKIAA1 EKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEK mKIAA1 ILMKCGFAF 340 >>mKIAA1076 ( 855 res) mbh01320 (855 aa) initn: 300 init1: 196 opt: 302 Z-score: 268.3 bits: 60.8 E(): 8.4e-10 Smith-Waterman score: 302; 29.255% identity (31.073% ungapped) in 188 aa overlap (39-223:675-854) 10 20 30 40 50 60 mKIAA1 DVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPC .: .:: : .: ... . ..: mKIAA1 DKKDKLRYLNSSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFT-GSCDS 650 660 670 680 690 700 70 80 90 100 110 120 mKIAA1 GEQCCNQ-RIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSE--QEFRN :: ...... : ... . ::. . ::. : ...:::.:. . . ..:. mKIAA1 DLLKFNQLKFRKKKLKFC----KSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMRE 710 720 730 740 750 130 140 150 160 170 180 mKIAA1 RMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYA . :. :. : . .: .::. . :: ::::::::.::: . .:.. .: .:. mKIAA1 KRYEDEGIGSS-YMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYS 760 770 780 790 800 810 190 200 210 220 230 240 mKIAA1 LKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRMNGLPSHKGSQSSSTH . . .. :.::::.: .:. : :: :.::: .. mKIAA1 KQHINVNEEITYDYKFPIEDVKIP--CLCGSENCRGTLN 820 830 840 850 250 260 270 280 290 300 mKIAA1 RKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVF >>mKIAA0304 ( 1744 res) mbg06324 (1744 aa) initn: 274 init1: 274 opt: 289 Z-score: 253.7 bits: 59.1 E(): 5.5e-09 Smith-Waterman score: 289; 35.821% identity (36.923% ungapped) in 134 aa overlap (89-220:1609-1740) 60 70 80 90 100 110 mKIAA1 AECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVV .:. .: :. :. . ::...::: : :. mKIAA0 RSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVI 1580 1590 1600 1610 1620 1630 120 130 140 150 160 170 mKIAA1 SEQEFRNRMIEQYHNHSDHYC--LNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVN .: :.... . : . .:. :.:. :: ::::::::.::: . :. mKIAA0 RSVLTDKR--EKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVE 1640 1650 1660 1670 1680 1690 180 190 200 210 220 230 mKIAA1 GVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRMNGLPSH : .: ..::. . : ::::::.: .. .. :.:: ..:: mKIAA0 GQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 1700 1710 1720 1730 1740 240 250 260 270 280 290 mKIAA1 KGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKPMSNRER >>mKIAA0339 ( 822 res) mph02448 (822 aa) initn: 242 init1: 177 opt: 283 Z-score: 251.9 bits: 57.7 E(): 6.9e-09 Smith-Waterman score: 283; 34.058% identity (36.154% ungapped) in 138 aa overlap (88-221:686-819) 60 70 80 90 100 110 mKIAA1 FAECSPNTCPCGEQCCNQRIQRHEWVQCLERF-RAEEKGWGIRTKEPLKAGQFIIEYLGE :: :.. . ::. . ::. : ...:::.:. mKIAA0 RRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQ 660 670 680 690 700 710 120 130 140 150 160 170 mKIAA1 VVSEQ--EFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWS . .. ..:.. : :. : . .: .::. . :: :::::: : ::: . . mKIAA0 NIRQMVADMREKRYVQEGIGSS-YLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVIT 720 730 740 750 760 770 180 190 200 210 220 230 mKIAA1 VNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQL-CKCGFEKCRGIIGGKSQRMNGL ... .: .:. . . . :.::::.: .: ... : :: :.::: mKIAA0 IESQKKIVIYSKQPIGVDEEITYDYKFP---LEDNKIPCLCGTESCRGSLN 780 790 800 810 820 240 250 260 270 280 290 mKIAA1 PSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKPMSN >>mKIAA1506 ( 1520 res) mbg19167 (1520 aa) initn: 245 init1: 245 opt: 260 Z-score: 229.0 bits: 54.3 E(): 1.3e-07 Smith-Waterman score: 260; 29.932% identity (30.769% ungapped) in 147 aa overlap (76-220:1372-1516) 50 60 70 80 90 100 mKIAA1 KGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLK : .. :: . . :.. .: :. . . .. mKIAA1 STSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIE 1350 1360 1370 1380 1390 1400 110 120 130 140 150 160 mKIAA1 AGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH-YCLNLDSGMVIDSYRMGNEARFINHSC ..:::.: .. ..: :: . :.... : . .:. :::. :. ::.::::: mKIAA1 KHTMVIEYIGTII-RNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSC 1410 1420 1430 1440 1450 1460 170 180 190 200 210 220 mKIAA1 DPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQL-CKCGFEKCRGII ::: . . . ..: . . . . : :: :::.: .:. ..... :.:: .:: mKIAA1 APNCVAEVVTFERGHKIIISSNRRIQKGEELCYDYKF-DFEDDQHKIPCHCGAVNCRKWM 1470 1480 1490 1500 1510 230 240 250 260 270 280 mKIAA1 GGKSQRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLT mKIAA1 N 1520 >>mKIAA1757 ( 1450 res) mbg10960 (1450 aa) initn: 224 init1: 159 opt: 236 Z-score: 208.2 bits: 50.4 E(): 1.9e-06 Smith-Waterman score: 247; 21.245% identity (24.205% ungapped) in 466 aa overlap (72-529:269-685) 50 60 70 80 90 100 mKIAA1 DDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTK : : : . .: . :.... .:. mKIAA1 QNALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAA 240 250 260 270 280 290 110 120 130 140 150 mKIAA1 EPLKAGQFIIEYLGEVVSEQEFR--NRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARF . : .:::: :.:. .:.:. ...... . : : .:. .::.::: mKIAA1 RDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF 300 310 320 330 340 350 160 170 180 190 200 210 mKIAA1 INHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELT--YDYNFHSFNVEKQQLCKCGFE : .:: :: :... ..:. .. .::.. . .:.: .::.. . : . . :. : . mKIAA1 IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNR 360 370 380 390 400 410 220 230 240 250 260 270 mKIAA1 KCRGIIGGKSQRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENIN .: : .. :: . . .. : : .:: . .:.... : :.:. mKIAA1 NCP--IQKRNPNAAELPLPPPPSFPTIGAETRRRKARRK-ELELEQQNEVPEENPD---- 420 430 440 450 460 470 280 290 300 310 320 330 mKIAA1 TPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIHQKQEEVKHTRDIHSASLYTRWNG :: : : :. : ..: . :: ..:: ... : . : ..: . mKIAA1 ------PQPQEVP----EKVTVSNEHEEVDNPEEK--PEEEEKEEATDDQENSAHSRRT- 480 490 500 510 340 350 360 370 380 390 mKIAA1 LCRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENLEVARAARLAQIFKEICDGIISY :.: .... .: : .:. .. : . . . ..:.. .. .:: : . mKIAA1 --REDRKVEA--IMHAFESLEKRKKRRDQPVEQSSSDIEITTSS------SEIVVGEETK 520 530 540 550 560 400 410 420 430 440 450 mKIAA1 RDSSQQTLAAPLLNLPPKKKNADYYEKISDPLDLSTIEKQILIGYYKTVEAFDADMLK-V . .. ...:. : .. : . .. .. .. .: :. : . mKIAA1 TAAPESEVSSPVSN-------------VAIP----STPQSTGVNTRRSSHAGDVAAEKPI 570 580 590 600 610 460 470 480 490 500 510 mKIAA1 FRNAEKYYGRKSPIGRDVCRLRKA---YYSARHEASAQIDEIVGETASEADSSETSVSEK . .: : .: . : : . . ...: :: :. ...: : .:..::. mKIAA1 PKPPPAKPSRPRPKSR-ISRYRTSSAQRLKRQKQAIAQQAEL-SQAALEEGGSNNSVTPP 620 630 640 650 660 520 530 540 550 560 570 mKIAA1 ESGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCDPRPVDR :.:. .. : . : mKIAA1 EAGNTDSSGENRQLTGSDPTVISVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVE 670 680 690 700 710 720 >>mKIAA0067 ( 1162 res) mbg05662 (1162 aa) initn: 206 init1: 92 opt: 204 Z-score: 181.3 bits: 45.1 E(): 5.9e-05 Smith-Waterman score: 204; 41.667% identity (44.304% ungapped) in 84 aa overlap (143-221:1076-1159) 120 130 140 150 160 170 mKIAA1 YLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQK .: ..::. :: .:..::::.:: .:. mKIAA0 IAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQN 1050 1060 1070 1080 1090 1100 180 190 200 210 220 mKIAA1 WSVNG----VYRIGLYALKDMPAGTELTYDYNFHSFNVE-KQQLCKCGFEKCRGIIGGKS :. ....: : . ::::::.:::.. .:: :. :: :: .::: mKIAA0 VFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1110 1120 1130 1140 1150 1160 230 240 250 260 270 280 mKIAA1 QRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQ 907 residues in 1 query sequences 1768110 residues in 2168 library sequences Scomplib [34t11] start: Mon Mar 27 10:44:18 2006 done: Mon Mar 27 10:44:19 2006 Scan time: 0.950 Display time: 0.290 Function used was FASTA [version 3.4t11 Apr 17, 2002]