# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mbh02336.fasta.nr -Q ../query/mKIAA1760.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 mKIAA1760, 1332 aa vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library 2727779818 residues in 7921681 sequences statistics sampled from 60000 to 7893874 sequences Expectation_n fit: rho(ln(x))= 7.1876+/-0.000213; mu= 7.1210+/- 0.012 mean_var=176.6955+/-34.217, 0's: 44 Z-trim: 109 B-trim: 926 in 2/65 Lambda= 0.096485 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 40, opt: 28, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7921681) gi|37994554|gb|AAH60187.1| Wnk2 protein [Mus muscu (1349) 7332 1034.0 0 gi|28386091|gb|AAH46464.1| Wnk2 protein [Mus muscu (1557) 7282 1027.1 0 gi|126253823|sp|Q3UH66.2|WNK2_MOUSE RecName: Full= (2149) 7228 1019.7 0 gi|109504743|ref|XP_225204.4| PREDICTED: similar t (2364) 6969 983.7 0 gi|157057176|ref|NP_083637.2| WNK lysine deficient (2059) 5843 826.9 0 gi|74184785|dbj|BAE27991.1| unnamed protein produc (2065) 5840 826.5 0 gi|194669647|ref|XP_582977.4| PREDICTED: WNK lysin (2280) 5250 744.4 1.9e-211 gi|119583262|gb|EAW62858.1| WNK lysine deficient p (2216) 4541 645.7 9.7e-182 gi|119583264|gb|EAW62860.1| WNK lysine deficient p (2210) 4523 643.2 5.5e-181 gi|208965700|dbj|BAG72864.1| WNK lysine deficient (2210) 4523 643.2 5.5e-181 gi|119583263|gb|EAW62859.1| WNK lysine deficient p (2217) 4523 643.2 5.5e-181 gi|32455273|ref|NP_006639.3| WNK lysine deficient (2217) 4523 643.2 5.5e-181 gi|150044395|emb|CAO03351.1| WNK lysine deficient (1772) 4426 629.6 5.4e-177 gi|150044396|emb|CAI12345.2| WNK lysine deficient (1013) 4186 596.0 4.2e-167 gi|74193362|dbj|BAE20646.1| unnamed protein produc ( 682) 4017 572.3 3.9e-160 gi|109112348|ref|XP_001108626.1| PREDICTED: simila (2142) 3521 503.7 5.2e-139 gi|119583261|gb|EAW62857.1| WNK lysine deficient p (2296) 3348 479.7 9.7e-132 gi|148709114|gb|EDL41060.1| mCG15641 [Mus musculus (1871) 3327 476.7 6.4e-131 gi|41688799|sp|Q9Y3S1.4|WNK2_HUMAN RecName: Full=S (2297) 3326 476.6 8.1e-131 gi|149045044|gb|EDL98130.1| similar to protein kin (1875) 3246 465.4 1.6e-127 gi|33416615|gb|AAH55795.1| Wnk2 protein [Mus muscu ( 570) 2902 417.0 1.8e-113 gi|23274217|gb|AAH37965.1| WNK2 protein [Homo sapi ( 650) 2788 401.2 1.2e-108 gi|119224007|gb|AAI26603.1| WNK2 protein [Bos taur ( 712) 2588 373.4 3e-100 gi|194224969|ref|XP_001917974.1| PREDICTED: simila (2060) 2350 340.7 5.9e-90 gi|150172265|emb|CAO03638.1| WNK lysine deficient ( 645) 2051 298.6 8.9e-78 gi|3170204|gb|AAC18051.1| antigen NY-CO-43 [Homo s ( 366) 1561 230.1 2.1e-57 gi|73947186|ref|XP_541326.2| PREDICTED: similar to (1644) 1524 225.6 2.1e-55 gi|126336546|ref|XP_001379127.1| PREDICTED: hypoth (2243) 1369 204.2 8e-49 gi|149412695|ref|XP_001508024.1| PREDICTED: simila (2425) 1347 201.2 7.1e-48 gi|224065365|ref|XP_002191745.1| PREDICTED: simila (2162) 1305 195.3 3.8e-46 gi|118096842|ref|XP_414326.2| PREDICTED: hypotheti (2183) 1156 174.5 6.6e-40 gi|74186476|dbj|BAE43209.1| unnamed protein produc ( 214) 774 120.3 1.3e-24 gi|11360241|pir||T50615 hypothetical protein DKFZp ( 216) 759 118.2 5.8e-24 gi|126340108|ref|XP_001366450.1| PREDICTED: simila (2406) 756 118.9 4.1e-23 gi|118763640|gb|AAI28629.1| LOC100036683 protein [ (2102) 751 118.1 6e-23 gi|126340106|ref|XP_001366397.1| PREDICTED: simila (2407) 748 117.8 8.9e-23 gi|119893176|ref|XP_582882.3| PREDICTED: similar t (2118) 747 117.6 8.9e-23 gi|189517952|ref|XP_689656.3| PREDICTED: si:ch211- (2344) 736 116.1 2.8e-22 gi|73997522|ref|XP_853960.1| PREDICTED: similar to (2389) 726 114.7 7.4e-22 gi|148667213|gb|EDK99629.1| WNK lysine deficient p (2389) 710 112.5 3.5e-21 gi|46577331|sp|P83741.1|WNK1_MOUSE RecName: Full=S (2377) 707 112.1 4.6e-21 gi|42741868|gb|AAS45192.1| protein kinase lysine d (2131) 700 111.0 8.4e-21 gi|219518601|gb|AAI45283.1| Unknown (protein for M (2195) 693 110.1 1.7e-20 gi|119609359|gb|EAW88953.1| WNK lysine deficient p (2225) 692 110.0 1.9e-20 gi|41688795|sp|Q9H4A3.1|WNK1_HUMAN RecName: Full=S (2382) 692 110.0 2e-20 gi|148612809|ref|NP_061852.2| WNK lysine deficient (2382) 692 110.0 2e-20 gi|41688742|sp|Q9JIH7.1|WNK1_RAT RecName: Full=Ser (2126) 691 109.8 2e-20 gi|114642781|ref|XP_001150360.1| PREDICTED: WNK ly (1975) 689 109.5 2.3e-20 gi|114642779|ref|XP_001150293.1| PREDICTED: WNK ly (1993) 689 109.5 2.3e-20 gi|114642771|ref|XP_001149832.1| PREDICTED: WNK ly (2225) 689 109.5 2.5e-20 >>gi|37994554|gb|AAH60187.1| Wnk2 protein [Mus musculus] (1349 aa) initn: 7196 init1: 3624 opt: 7332 Z-score: 5521.5 bits: 1034.0 E(): 0 Smith-Waterman score: 8127; 92.548% identity (92.623% similar) in 1342 aa overlap (41-1283:1-1342) 20 30 40 50 60 70 mKIAA1 PQGWGTRPWTRPVHACLQGLLAREMPQMPVVPPITPLTGLDGLPQTLTDLPAANVAPVPP :::::::::::::::::::::::::::::: gi|379 VPPITPLTGLDGLPQTLTDLPAANVAPVPP 10 20 30 80 90 100 110 120 130 mKIAA1 PQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAIPLLAVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 PQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAIPLLAVAP 40 50 60 70 80 90 140 150 160 170 180 190 mKIAA1 QGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLASPVPPQPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 QGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLASPVPPQPV 100 110 120 130 140 150 200 210 mKIAA1 QPSVIHLPEQAAPTAASGTQ---------------------------------------- :::::::::::::::::::: gi|379 QPSVIHLPEQAAPTAASGTQVLLGHPPSYTADVAAPVSAVSLPPAVLSPPLPDTLLPTVP 160 170 180 190 200 210 mKIAA1 ----------------------------------------------------------EQ :: gi|379 DLLPKVPSSLAPTVVAASQSAPAQTSSLLLPTNPPLPTGPAVAGPCPAVQLMVEVAQEEQ 220 230 240 250 260 270 220 230 240 250 260 270 mKIAA1 VSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRSTRARSRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 VSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRSTRARSRQE 280 290 300 310 320 330 280 290 300 310 320 330 mKIAA1 RASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 RASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILPAE 340 350 360 370 380 390 340 350 360 370 380 390 mKIAA1 RETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQANAPVYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 RETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQANAPVYQ 400 410 420 430 440 450 400 410 420 430 440 450 mKIAA1 QNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSLTDKPSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 QNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSLTDKPSFP 460 470 480 490 500 510 460 470 480 490 500 510 mKIAA1 AAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQAGGPGTHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 AAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQAGGPGTHQ 520 530 540 550 560 570 520 530 540 550 560 570 mKIAA1 GPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTREVSTQGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 GPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTREVSTQGEP 580 590 600 610 620 630 580 590 600 610 620 630 mKIAA1 LPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPPPSALESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 LPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPPPSALESD 640 650 660 670 680 690 640 650 660 670 680 690 mKIAA1 GEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEPLRGDLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 GEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEPLRGDLPS 700 710 720 730 740 750 700 710 720 730 740 750 mKIAA1 ALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMT-ESSSSNTLGCDSDAGQVA ::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::: gi|379 ALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMTAESSSSNTLGCDSDAGQVA 760 770 780 790 800 810 760 770 780 790 800 810 mKIAA1 SDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPAQLRGARD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 SDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPAQLRGARD 820 830 840 850 860 870 820 830 840 850 860 870 mKIAA1 SGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEIPSSPEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 SGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEIPSSPEVK 880 890 900 910 920 930 880 890 900 910 920 930 mKIAA1 LAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVKKATAFLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 LAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVKKATAFLH 940 950 960 970 980 990 940 950 960 970 980 990 mKIAA1 RSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELRSLREKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 RSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELRSLREKHL 1000 1010 1020 1030 1040 1050 1000 1010 1020 1030 1040 1050 mKIAA1 KEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGKLLNPLVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 KEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGKLLNPLVQ 1060 1070 1080 1090 1100 1110 1060 1070 1080 1090 1100 1110 mKIAA1 QLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLSTDICSGLASDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 QLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLSTDICSGLASDG 1120 1130 1140 1150 1160 1170 1120 1130 1140 1150 1160 1170 mKIAA1 GGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 GGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSS 1180 1190 1200 1210 1220 1230 1180 1190 1200 1210 1220 1230 mKIAA1 LAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPTLNQLKQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|379 LAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPTLNQLKQT 1240 1250 1260 1270 1280 1290 1240 1250 1260 1270 1280 1290 mKIAA1 QKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPEACALPTPP :::::::::::::::::::::::::::::::::::::::::::::::::::. gi|379 QKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPDPESEKPD 1300 1310 1320 1330 1340 1300 1310 1320 1330 mKIAA1 CKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG >>gi|28386091|gb|AAH46464.1| Wnk2 protein [Mus musculus] (1557 aa) initn: 5543 init1: 4785 opt: 7282 Z-score: 5483.1 bits: 1027.1 E(): 0 Smith-Waterman score: 7948; 95.923% identity (96.083% similar) in 1251 aa overlap (34-1283:348-1550) 10 20 30 40 50 60 mKIAA1 LWPIFCSPQGWGTRPWTRPVHACLQGLLAREMPQMPVVPPITPLTGLDGLPQTLTDLPAA .::::::::::::::::::::::::::::: gi|283 APTSQVVAPAQLKPLQMPQPPLQPLAQVPPQMPQMPVVPPITPLTGLDGLPQTLTDLPAA 320 330 340 350 360 370 70 80 90 100 110 120 mKIAA1 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI 380 390 400 410 420 430 130 140 150 160 170 180 mKIAA1 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS 440 450 460 470 480 490 190 200 210 220 230 240 mKIAA1 PVPPQPVQPSVIHLPEQAAPTAASGTQEQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 PVPPQPVQPSVIHLPEQAAPTAASGTQEQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSC 500 510 520 530 540 550 250 260 270 280 290 300 mKIAA1 EGTFGGGRLEGRTARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 EGTFGGGRLEGRTARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKM 560 570 580 590 600 610 310 320 330 340 350 360 mKIAA1 VTFKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 VTFKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDT 620 630 640 650 660 670 370 380 390 400 410 420 mKIAA1 GTSPPHLGTCGLATGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 GTSPPHLGTCGLATGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPL 680 690 700 710 720 730 430 440 450 460 470 480 mKIAA1 PLSSLQPEASQDPAPYPDQLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 PLSSLQPEASQDPAPYPDQLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTT 740 750 760 770 780 790 490 500 510 520 530 540 mKIAA1 VIPAAPATSTVPESAAGTAMQAGGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 VIPAAPATSTVPESAAGTAMQAGGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGP 800 810 820 830 840 850 550 560 570 580 590 600 mKIAA1 CTPALEASRCSTGLGEPISTREVSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 CTPALEASRCSTGLGEPISTREVSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVG 860 870 880 890 900 910 610 620 630 640 650 660 mKIAA1 AISLAAPQLPSPPLGPTAPPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 AISLAAPQLPSPPLGPTAPPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHV 920 930 940 950 960 970 670 680 690 700 710 720 mKIAA1 PTSSASAGTPMEASDRDFTLEPLRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 PTSSASAGTPMEASDRDFTLEPLRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQ 980 990 1000 1010 1020 1030 730 740 750 760 770 780 mKIAA1 REQGASSPMT-ESSSSNTLGCDSDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSV :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 REQGASSPMTAESSSSNTLGCDSDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSV 1040 1050 1060 1070 1080 1090 790 800 810 820 830 840 mKIAA1 PREALAAPMQSGPGSFTVGSPAQLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 PREALAAPMQSGPGSFTVGSPAQLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDE 1100 1110 1120 1130 1140 1150 850 860 870 880 890 900 mKIAA1 WTLASPHSLRYSAPPDVYLDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 WTLASPHSLRYSAPPDVYLDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRR 1160 1170 1180 1190 1200 1210 910 920 930 940 950 960 mKIAA1 RSQVQKQSSLPGTGGVASDFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 RSQVQKQSSLPGTGGVASDFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQ 1220 1230 1240 1250 1260 1270 970 980 990 1000 1010 1020 mKIAA1 SSYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 SSYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGF 1280 1290 1300 1310 1320 1330 1030 1040 1050 1060 1070 1080 mKIAA1 FHTAPPMGRRRKTSKSKLKAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 FHTAPPMGRRRKTSKSKLKAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPP 1340 1350 1360 1370 1380 1390 1090 1100 1110 1120 1130 1140 mKIAA1 GTKAVQTQQPCSVRASLSTDICSGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFL :::::::::::::::::::::::::::::::::::: gi|283 GTKAVQTQQPCSVRASLSTDICSGLASDGGGARGQG------------------------ 1400 1410 1420 1430 1150 1160 1170 1180 1190 1200 mKIAA1 SGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTD :::::::::::::::::::::::::::::::::::: gi|283 ------------------------SSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTD 1440 1450 1460 1210 1220 1230 1240 1250 1260 mKIAA1 DLHKLVDEWTTKTVGAAQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|283 DLHKLVDEWTTKTVGAAQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAP 1470 1480 1490 1500 1510 1520 1270 1280 1290 1300 1310 1320 mKIAA1 GPLSTTATPGATPALPVPIPEACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGER ::::::::::::::::::::. gi|283 GPLSTTATPGATPALPVPIPDPESEKPD 1530 1540 1550 >>gi|126253823|sp|Q3UH66.2|WNK2_MOUSE RecName: Full=Seri (2149 aa) initn: 7061 init1: 3586 opt: 7228 Z-score: 5440.7 bits: 1019.7 E(): 0 Smith-Waterman score: 8071; 91.513% identity (91.661% similar) in 1355 aa overlap (34-1283:794-2142) 10 20 30 40 50 60 mKIAA1 LWPIFCSPQGWGTRPWTRPVHACLQGLLAREMPQMPVVPPITPLTGLDGLPQTLTDLPAA .::::::::::::::::::::::::::::: gi|126 APTSQVVAPAQLKPLQMPQPPLQPLAQVPPQMPQMPVVPPITPLTGLDGLPQTLTDLPAA 770 780 790 800 810 820 70 80 90 100 110 120 mKIAA1 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI 830 840 850 860 870 880 130 140 150 160 170 180 mKIAA1 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS 890 900 910 920 930 940 190 200 210 mKIAA1 PVPPQPVQPSVIHLPEQAAPTAASGTQ--------------------------------- ::::::::::::::::::::::::::: gi|126 PVPPQPVQPSVIHLPEQAAPTAASGTQVLLGHPPSYTADVAAPVSAVSLPPAVLSPPLPD 950 960 970 980 990 1000 mKIAA1 ------------------------------------------------------------ gi|126 TLLPTVPDLLPKVPSSLAPTVVAASQSAPAQTSSLLLPTNPPLPTGPAVAGPCPAVQLMV 1010 1020 1030 1040 1050 1060 220 230 240 250 260 mKIAA1 -----EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRST ::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 EVAQEEQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRST 1070 1080 1090 1100 1110 1120 270 280 290 300 310 320 mKIAA1 RARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 RARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEH 1130 1140 1150 1160 1170 1180 330 340 350 360 370 380 mKIAA1 DFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 DFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQ 1190 1200 1210 1220 1230 1240 390 400 410 420 430 440 mKIAA1 ANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 ANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSL 1250 1260 1270 1280 1290 1300 450 460 470 480 490 500 mKIAA1 TDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 TDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQA 1310 1320 1330 1340 1350 1360 510 520 530 540 550 560 mKIAA1 GGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 GGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTRE 1370 1380 1390 1400 1410 1420 570 580 590 600 610 620 mKIAA1 VSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 VSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPP 1430 1440 1450 1460 1470 1480 630 640 650 660 670 680 mKIAA1 PSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 PSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEP 1490 1500 1510 1520 1530 1540 690 700 710 720 730 740 mKIAA1 LRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMT-ESSSSNTLGCD :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: gi|126 LRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMTAESSSSNTLGCD 1550 1560 1570 1580 1590 1600 750 760 770 780 790 800 mKIAA1 SDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 SDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPA 1610 1620 1630 1640 1650 1660 810 820 830 840 850 860 mKIAA1 QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEI 1670 1680 1690 1700 1710 1720 870 880 890 900 910 920 mKIAA1 PSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 PSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVK 1730 1740 1750 1760 1770 1780 930 940 950 960 970 980 mKIAA1 KATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 KATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELR 1790 1800 1810 1820 1830 1840 990 1000 1010 1020 1030 1040 mKIAA1 SLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 SLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGK 1850 1860 1870 1880 1890 1900 1050 1060 1070 1080 1090 1100 mKIAA1 LLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLSTDIC ::::::::::::::::::::::::::::::: :::::::::::::::::::::: gi|126 LLNPLVQQLKVVASSTGHLSDSSRGPPTKDPR------GTKAVQTQQPCSVRASLSTDIC 1910 1920 1930 1940 1950 1110 1120 1130 1140 1150 1160 mKIAA1 SGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 SGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHS 1960 1970 1980 1990 2000 2010 1170 1180 1190 1200 1210 mKIAA1 SR------SSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGA : :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 SSLYDSPGSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGA 2020 2030 2040 2050 2060 2070 1220 1230 1240 1250 1260 1270 mKIAA1 AQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 AQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALP 2080 2090 2100 2110 2120 2130 1280 1290 1300 1310 1320 1330 mKIAA1 VPIPEACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG ::::. gi|126 VPIPDPESEKPD 2140 >>gi|109504743|ref|XP_225204.4| PREDICTED: similar to WN (2364 aa) initn: 7638 init1: 3483 opt: 6969 Z-score: 5245.4 bits: 983.7 E(): 0 Smith-Waterman score: 7752; 87.361% identity (90.835% similar) in 1353 aa overlap (34-1283:1005-2357) 10 20 30 40 50 60 mKIAA1 LWPIFCSPQGWGTRPWTRPVHACLQGLLAREMPQMPVVPPITPLTGLDGLPQTLTDLPAA .:::::::::::::.:::::::::.::::: gi|109 APTSQVVAPAQLKPLQMPQPPLQPLAQVPPQMPQMPVVPPITPLAGLDGLPQTLADLPAA 980 990 1000 1010 1020 1030 70 80 90 100 110 120 mKIAA1 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI :::::::::::::::::::::::::::::::.::::::::::.::::::::::::::::: gi|109 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPLQAVKLPHPPGAPLAVPCQTIVPNAPAAI 1040 1050 1060 1070 1080 1090 130 140 150 160 170 mKIAA1 PLLAVAPQGVAALSIHPAVAQIPAQ----PVYPAAFPQMVPGDIPPSPHHTVQSLRATPP ::::::::::::::::::::::::: :::::::: :::::.:::::::::::::::: gi|109 PLLAVAPQGVAALSIHPAVAQIPAQIPAQPVYPAAFPGMVPGDVPPSPHHTVQSLRATPP 1100 1110 1120 1130 1140 1150 180 190 200 210 mKIAA1 QLASPVPPQPVQPSVIHLPEQAAPTAASGTQ----------------------------- :::: :::: :::::.::::::::.:::::: gi|109 QLASSVPPQSVQPSVVHLPEQAAPSAASGTQVLLGHPPSYTTDVAAPVSAVSLPPAVLSP 1160 1170 1180 1190 1200 1210 mKIAA1 ------------------------------------------------------------ gi|109 PLPDTLLPTVPELLPKLPSSLAPTVVAASQSVPTQTSTLLPPTNPPLPTGPAVAGPCPAV 1220 1230 1240 1250 1260 1270 220 230 240 250 260 mKIAA1 ---------EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHH :::::::::::::: ::.:::::::::::::.:::::: ::::::.::::: gi|109 QLTVEAAQEEQVSQDKPPGPPQSCESLGGSDVTSGRDLSDNCEGTFGTGRLEGRAARKHH 1280 1290 1300 1310 1320 1330 270 280 290 300 310 320 mKIAA1 RRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATY 1340 1350 1360 1370 1380 1390 330 340 350 360 370 380 mKIAA1 MVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEEN ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|109 MVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLTTGEEN 1400 1410 1420 1430 1440 1450 390 400 410 420 430 440 mKIAA1 RQSQANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPD :::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|109 GQSQANAPVYQQNVLHTGKRWFIICPVAEHPAADTSESSPPLPLSSLQPEASQDPAPYPD 1460 1470 1480 1490 1500 1510 450 460 470 480 490 500 mKIAA1 QLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGT :::::::::::::::::::::::::::::::: ::::::::.:.:::::::::::::::: gi|109 QLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPTAPSSPPVTSVMPAAPATSTVPESAAGT 1520 1530 1540 1550 1560 1570 510 520 530 540 550 560 mKIAA1 AMQAGGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPI ::::::::::::::::::::.:::::. :: .::::::::::::::::::.::::::::: gi|109 AMQAGGPGTHQGPASVHETLHPLAETHRAQGAAQPLSTGQGPCTPALEASHCSTGLGEPI 1580 1590 1600 1610 1620 1630 570 580 590 600 610 620 mKIAA1 STREVSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTA ::.:::::: : ::.:::::::::.::::.:::::::::::.:.::::::::::::::: gi|109 STKEVSTQGGTLSASMPEPSPPTGAVQSVPSQPPPPLPITVGTIGLAAPQLPSPPLGPTA 1640 1650 1660 1670 1680 1690 630 640 650 660 670 680 mKIAA1 PPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDF ::::::::::::::::::::::::::::::::::::::::::::::::::::.::.:::: gi|109 PPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPLEANDRDF 1700 1710 1720 1730 1740 1750 690 700 710 720 730 740 mKIAA1 TLEPLRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMT-ESSSSNT :::::::::::::::::::::::.::::::::::::::::: ::::::: :: ::::::: gi|109 TLEPLRGDLPSALSDKTPSLTQQSQPSLEKSETAPAGWALAPREQGASSSMTAESSSSNT 1760 1770 1780 1790 1800 1810 750 760 770 780 790 800 mKIAA1 LGCDSDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTV ::::::.::::::: ::::::::.: :::::::::::::.:.:::.:.::::: ::.:: gi|109 LGCDSDTGQVASDSPTAPSVPQDTSVSSVPTHMDPKDQNGSAPRETLVAPMQSCPGTFTE 1820 1830 1840 1850 1860 1870 810 820 830 840 850 860 mKIAA1 GSPAQLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVY ::::::::.::::::::::::::.:::::::::::::::::::::::::::::::::::: gi|109 GSPAQLRGVRDSGSPHKRPGQQDSSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVY 1880 1890 1900 1910 1920 1930 870 880 890 900 910 920 mKIAA1 LDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVAS :::::::::::::::::::::::::::::::::::::: ::::.::::::::::.::::: gi|109 LDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDECPRRRTQVQKQSSLPGSGGVAS 1940 1950 1960 1970 1980 1990 930 940 950 960 970 980 mKIAA1 DFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 DFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIK 2000 2010 2020 2030 2040 2050 990 1000 1010 1020 1030 1040 mKIAA1 KELRSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KELRSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKL 2060 2070 2080 2090 2100 2110 1050 1060 1070 1080 1090 1100 mKIAA1 KAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLS 2120 2130 2140 2150 2160 2170 1110 1120 1130 1140 1150 1160 mKIAA1 TDICSGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 TDICSGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLG 2180 2190 2200 2210 2220 2230 1170 1180 1190 1200 1210 1220 mKIAA1 KEHSSRSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KEHSSRSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQ 2240 2250 2260 2270 2280 2290 1230 1240 1250 1260 1270 1280 mKIAA1 VKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVP :::::::::::::::::::::.::::::::..:..:::::::::::.:: ::.::::::: gi|109 VKPTLNQLKQTQKLHDMEASGEARATSVPRGGVATSCLAPAPGPLSSTAIPGVTPALPVP 2300 2310 2320 2330 2340 2350 1290 1300 1310 1320 1330 mKIAA1 IPEACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG :. gi|109 TPDPESEKPD 2360 >>gi|157057176|ref|NP_083637.2| WNK lysine deficient pro (2059 aa) initn: 4442 init1: 3586 opt: 5843 Z-score: 4399.0 bits: 826.9 E(): 0 Smith-Waterman score: 7363; 85.841% identity (85.990% similar) in 1349 aa overlap (34-1283:794-2052) 10 20 30 40 50 60 mKIAA1 LWPIFCSPQGWGTRPWTRPVHACLQGLLAREMPQMPVVPPITPLTGLDGLPQTLTDLPAA .::::::::::::::::::::::::::::: gi|157 APTSQVVAPAQLKPLQMPQPPLQPLAQVPPQMPQMPVVPPITPLTGLDGLPQTLTDLPAA 770 780 790 800 810 820 70 80 90 100 110 120 mKIAA1 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI 830 840 850 860 870 880 130 140 150 160 170 180 mKIAA1 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS 890 900 910 920 930 940 190 200 210 mKIAA1 PVPPQPVQPSVIHLPEQAAPTAASGTQ--------------------------------- ::::::::::::::::::::::::::: gi|157 PVPPQPVQPSVIHLPEQAAPTAASGTQVLLGHPPSYTADVAAPVSAVSLPPAVLSPPLPD 950 960 970 980 990 1000 mKIAA1 ------------------------------------------------------------ gi|157 TLLPTVPDLLPKVPSSLAPTVVAASQSAPAQTSSLLLPTNPPLPTGPAVAGPCPAVQLMV 1010 1020 1030 1040 1050 1060 220 230 240 250 260 mKIAA1 -----EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRST ::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 EVAQEEQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRST 1070 1080 1090 1100 1110 1120 270 280 290 300 310 320 mKIAA1 RARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 RARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEH 1130 1140 1150 1160 1170 1180 330 340 350 360 370 380 mKIAA1 DFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 DFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQ 1190 1200 1210 1220 1230 1240 390 400 410 420 430 440 mKIAA1 ANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 ANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSL 1250 1260 1270 1280 1290 1300 450 460 470 480 490 500 mKIAA1 TDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 TDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQA 1310 1320 1330 1340 1350 1360 510 520 530 540 550 560 mKIAA1 GGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 GGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTRE 1370 1380 1390 1400 1410 1420 570 580 590 600 610 620 mKIAA1 VSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 VSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPP 1430 1440 1450 1460 1470 1480 630 640 650 660 670 680 mKIAA1 PSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 PSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEP 1490 1500 1510 1520 1530 1540 690 700 710 720 730 740 mKIAA1 LRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMT-ESSSSNTLGCD :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: gi|157 LRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMTAESSSSNTLGCD 1550 1560 1570 1580 1590 1600 750 760 770 780 790 800 mKIAA1 SDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 SDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPA 1610 1620 1630 1640 1650 1660 810 820 830 840 850 860 mKIAA1 QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEI 1670 1680 1690 1700 1710 1720 870 880 890 900 910 920 mKIAA1 PSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 PSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVK 1730 1740 1750 1760 1770 1780 930 940 950 960 970 980 mKIAA1 KATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 KATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELR 1790 1800 1810 1820 1830 1840 990 1000 1010 1020 1030 1040 mKIAA1 SLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 SLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGK 1850 1860 1870 1880 1890 1900 1050 1060 1070 1080 1090 1100 mKIAA1 LLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLSTDIC ::::::::::::::::: gi|157 LLNPLVQQLKVVASSTG------------------------------------------- 1910 1920 1110 1120 1130 1140 1150 1160 mKIAA1 SGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHS ::::::::::::: gi|157 -----------------------------------------------SALKRLCLGKEHS 1930 1170 1180 1190 1200 1210 1220 mKIAA1 SRSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|157 SRSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPT 1940 1950 1960 1970 1980 1990 1230 1240 1250 1260 1270 1280 mKIAA1 LNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPEA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|157 LNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPDP 2000 2010 2020 2030 2040 2050 1290 1300 1310 1320 1330 mKIAA1 CALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG gi|157 ESEKPD >>gi|74184785|dbj|BAE27991.1| unnamed protein product [M (2065 aa) initn: 4426 init1: 3586 opt: 5840 Z-score: 4396.8 bits: 826.5 E(): 0 Smith-Waterman score: 7333; 85.387% identity (85.535% similar) in 1355 aa overlap (34-1283:794-2058) 10 20 30 40 50 60 mKIAA1 LWPIFCSPQGWGTRPWTRPVHACLQGLLAREMPQMPVVPPITPLTGLDGLPQTLTDLPAA .::::::::::::::::::::::::::::: gi|741 APTSQVVAPAQLKPLQMPQPPLQPLAQVPPQMPQMPVVPPITPLTGLDGLPQTLTDLPAA 770 780 790 800 810 820 70 80 90 100 110 120 mKIAA1 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 NVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPAAI 830 840 850 860 870 880 130 140 150 160 170 180 mKIAA1 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 PLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLAS 890 900 910 920 930 940 190 200 210 mKIAA1 PVPPQPVQPSVIHLPEQAAPTAASGTQ--------------------------------- ::::::::::::::::::::::::::: gi|741 PVPPQPVQPSVIHLPEQAAPTAASGTQVLLGHPPSYTADVAAPVSAVSLPPAVLSPPLPD 950 960 970 980 990 1000 mKIAA1 ------------------------------------------------------------ gi|741 TLLPTVPDLLPKVPSSLAPTVVAASQSAPAQTSSLLLPTNPPLPTGPAVAGPCPAVQLMV 1010 1020 1030 1040 1050 1060 220 230 240 250 260 mKIAA1 -----EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRST ::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 EVAQEEQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRST 1070 1080 1090 1100 1110 1120 270 280 290 300 310 320 mKIAA1 RARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 RARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEH 1130 1140 1150 1160 1170 1180 330 340 350 360 370 380 mKIAA1 DFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 DFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQ 1190 1200 1210 1220 1230 1240 390 400 410 420 430 440 mKIAA1 ANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 ANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSL 1250 1260 1270 1280 1290 1300 450 460 470 480 490 500 mKIAA1 TDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 TDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQA 1310 1320 1330 1340 1350 1360 510 520 530 540 550 560 mKIAA1 GGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 GGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTRE 1370 1380 1390 1400 1410 1420 570 580 590 600 610 620 mKIAA1 VSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 VSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPP 1430 1440 1450 1460 1470 1480 630 640 650 660 670 680 mKIAA1 PSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 PSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEP 1490 1500 1510 1520 1530 1540 690 700 710 720 730 740 mKIAA1 LRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMT-ESSSSNTLGCD :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: gi|741 LRGDLPSALSDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMTAESSSSNTLGCD 1550 1560 1570 1580 1590 1600 750 760 770 780 790 800 mKIAA1 SDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 SDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPA 1610 1620 1630 1640 1650 1660 810 820 830 840 850 860 mKIAA1 QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEI 1670 1680 1690 1700 1710 1720 870 880 890 900 910 920 mKIAA1 PSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 PSSPEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVK 1730 1740 1750 1760 1770 1780 930 940 950 960 970 980 mKIAA1 KATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 KATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELR 1790 1800 1810 1820 1830 1840 990 1000 1010 1020 1030 1040 mKIAA1 SLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 SLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGK 1850 1860 1870 1880 1890 1900 1050 1060 1070 1080 1090 1100 mKIAA1 LLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASLSTDIC ::::::::::::::::: gi|741 LLNPLVQQLKVVASSTG------------------------------------------- 1910 1920 1110 1120 1130 1140 1150 1160 mKIAA1 SGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHS ::::::::::::: gi|741 -----------------------------------------------SALKRLCLGKEHS 1930 1170 1180 1190 1200 1210 mKIAA1 SR------SSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGA : :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 SSLYDSPGSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGA 1940 1950 1960 1970 1980 1990 1220 1230 1240 1250 1260 1270 mKIAA1 AQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 AQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALP 2000 2010 2020 2030 2040 2050 1280 1290 1300 1310 1320 1330 mKIAA1 VPIPEACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG ::::. gi|741 VPIPDPESEKPD 2060 >>gi|194669647|ref|XP_582977.4| PREDICTED: WNK lysine de (2280 aa) initn: 3666 init1: 1727 opt: 5250 Z-score: 3952.4 bits: 744.4 E(): 1.9e-211 Smith-Waterman score: 5869; 65.149% identity (76.766% similar) in 1472 aa overlap (6-1291:755-2221) 10 20 30 mKIAA1 RRYLWPIFCSPQGWGTRP-WTRPVH---ACLQGL- : . .: . . : .:.. : :: : gi|194 QPSLLAQPVPLPQVLAPQPVGPLQPAPSHLPPYLAPASQVVAPAQLKPLQMPPAPLQPLA 730 740 750 760 770 780 40 50 60 70 80 mKIAA1 -LAREMPQMPVVPPITPLTGLDGLPQTLTDLPAANVAPVPPP-QYFSPAVILPSLT---- . .:: .::::::.::. .:.:: .: ::::.. :::: ::: :::::::: gi|194 QIPPQMPPLPVVPPIAPLATVDSLPTALPDLPATSGPTVPPPSQYFPPAVILPSLPLSAT 790 800 810 820 830 840 90 100 110 120 130 140 mKIAA1 -TPLPTSPALPMQAVKLPHPPGTPLAVPCQTIVPNAPA---AIPLLAVAPQGVAALSIHP .:::.:::::.:.:::::: :.::::::::::::. : ::::::::::::::::::: gi|194 PAPLPASPALPLQTVKLPHPAGAPLAVPCQTIVPNVAATATAIPLLAVAPQGVAALSIHP 850 860 870 880 890 900 150 160 170 180 190 200 mKIAA1 AVAQIPAQPVYPAAFPQMVPGDIPPSPHHTVQSLRATPPQLASPVPPQPVQPSVIHLPEQ .:::.:::::::::::::::.:.:::: :..:...:. :: . :: ::: :::: .:::: gi|194 TVAQLPAQPVYPAAFPQMVPSDVPPSPLHAAQTVQAAAPQPTPPVLPQPHQPSVARLPEQ 910 920 930 940 950 960 210 mKIAA1 AAPTAASGTQ-------------------------------------------------- :::.:..:.: gi|194 AAPAASAGSQHVLGALGTGLTKSFAVGSFPGVGGAVCGGGGSLAMLGIVASALTWIELAV 970 980 990 1000 1010 1020 mKIAA1 ------------------------------------------------------------ gi|194 LILLGHPPTYAVDVTTQVATVPAPAAILSPPLPEVLLPPVPELLPQLPGSLAPTVIAAPQ 1030 1040 1050 1060 1070 1080 220 230 mKIAA1 ---------------------------------------EQVSQDKPPGPPQSSESFGGS ::.:::: :. ::: ::.::: gi|194 SVPVQTAALLPPANLPLPSGPGIPGPCPTVQLTVEPAPEEQASQDKQPSLPQSCESYGGS 1090 1100 1110 1120 1130 1140 240 250 260 270 280 290 mKIAA1 DVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRSTRARSRQERASRPRLTILNVCNTGDKM :: :::..::::::.::::.:::..::::::::::.:::::::::::::::::::::::: gi|194 DVPSGREMSDSCEGAFGGGKLEGKAARKHHRRSTRVRSRQERASRPRLTILNVCNTGDKM 1150 1160 1170 1180 1190 1200 300 310 320 330 340 350 mKIAA1 VECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDML :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|194 VECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDML 1210 1220 1230 1240 1250 1260 360 370 380 390 400 410 mKIAA1 SEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEH :::::.:..:: :.:::::.::::..:::::::::::::::::::::::::::::::::: gi|194 SEDTDVDRASDPGVSPPHLSTCGLGAGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEH 1270 1280 1290 1300 1310 1320 420 430 440 450 460 470 mKIAA1 PATDTSESSPPLPLSSLQPEASQDPAPYPDQLSLTDKPSFPAAQQLLSQAGSSNPPGGAS ::... :::::::::::::..::: :: :::: .:::: . ::::::: . :::: gi|194 PAVEAPESSPPLPLSSLQPDTSQDSAPSKDQLSSKEKPSFSTDLQLLSQAGPRDLPGGAP 1330 1340 1350 1360 1370 1380 480 490 500 510 520 mKIAA1 APLAPSSPPVTTVIP--AAPATSTVPESAAGTAMQAGGPGTHQGPASVHETLQPLAETRS :::.:::::::.. : ::.: : :.: ::::::::: ::::: :.: :: :: . gi|194 APLVPSSPPVTALSQDMAPPAASPKLEPATGPAMQAGGPGTPQGPASEHKTPWPLMETLD 1390 1400 1410 1420 1430 1440 530 540 550 560 570 580 mKIAA1 AQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTREVSTQGEPLPASVPEPSPPTGATQS :: .:: . :.:::.: ::: :::.: .:: :.:::: : .: . : ::.: gi|194 AQLAAQSPGMGRGPCAPPLEAPLHPMGLGDPALAREPITKGEPLSALAPTSGAPGGASQP 1450 1460 1470 1480 1490 1500 590 600 610 620 630 640 mKIAA1 VPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPPPSALESDGEGPPPRVGFVDNTIKS . .:: :::: .:::::::.::::::::.::::: :::.::::::::::::::::.:::: gi|194 TVSQPLPPLPTVVGAISLATPQLPSPPLAPTAPPQPPSTLESDGEGPPPRVGFVDSTIKS 1510 1520 1530 1540 1550 1560 650 660 670 680 690 700 mKIAA1 LDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEPLRGDLPSALSDKTPSLTQQTQPSL ::::::::::::::::::::::::.::.:::::::: ::: : . .. :: ::.: gi|194 LDEKLRTLLYQEHVPTSSASAGTPVEAGDRDFTLEPPRGDEPRTEASGG-SLGLLPQPAL 1570 1580 1590 1600 1610 1620 710 720 730 740 750 760 mKIAA1 EKSETAPAGWALAQREQGASSPMTESSSSNTLGCDSDAGQVASDSSTAPSVPQDASGSSV ::::.:: : .. ... . : .::: :.::: ...:::::: ::: .:::. .:.. gi|194 EKSEVAP-GLEVTLEQSVSLSVTAESSLSHTLG--REGAQVASDSRTAPRAPQDVPASAI 1630 1640 1650 1660 1670 1680 770 780 790 800 810 820 mKIAA1 PTHMDPKDQNSSVPREALAAPMQSGPGSFTVG---SPAQLRGARDSGSPHKRPGQQDNSS :.:..: :..: :: :.:: ::: : . : : : ... :::: : :::::.:: gi|194 PAHLEPTDRTSRVPGETLAESMQSCLGMLIEGGQDSQPQPHSTLVSGSPLKWPGQQDGSS 1690 1700 1710 1720 1730 1740 830 840 850 860 870 880 mKIAA1 PAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEIPSSPEVKLAVRRVQTASSIEVG ::::::::::::::::::::::.:::::::::::::: : ::..::::::.::::::::: gi|194 PAKTVGRFSVVSTQDEWTLASPNSLRYSAPPDVYLDEAPCSPDMKLAVRRAQTASSIEVG 1750 1760 1770 1780 1790 1800 890 900 910 920 930 940 mKIAA1 VEEPASSDSGDERPRRRSQVQKQSSLPGT-GGVASDFVKKATAFLHRSSRAGSLGPETPS .::: ::::::: :::: .:::..:::.. :::::::::::.:::.::::::: :::: gi|194 MEEPLSSDSGDESPRRRPSVQKHASLPSSSGGVASDFVKKAAAFLQRSSRAGSPCLETPS 1810 1820 1830 1840 1850 1860 950 960 970 980 990 1000 mKIAA1 RAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEI : ::::::::.:::::::::::::::::.:::::.:::.::::::::::::::::::::: gi|194 RMGVKVPTISVTSFHSQSSYISSDNDSEIEDADIRKELQSLREKHLKEISELQSQQKQEI 1870 1880 1890 1900 1910 1920 1010 1020 1030 1040 1050 1060 mKIAA1 EALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLKAGKLLNPLVQQLKVVASSTGHLSD ::::::::::::::.:.::::::.:::::::::::::::::.:::::::::::::::::: gi|194 EALYRRLGKPLPPNLGLFHTAPPIGRRRKTSKSKLKAGKLLSPLVQQLKVVASSTGHLSD 1930 1940 1950 1960 1970 1980 1070 1080 1090 1100 1110 mKIAA1 SSRGPPTKDPAHA------STPPGTKAVQTQQPCSVRASLSTDICSGLASDGGGARGQGW ::.::.::::.: .. : ::::::::::::::::.:::::::::::::.: :: gi|194 CSRAPPAKDPAQAGAGPTAASDPCGKAVQTQQPCSVRASLSADICSGLASDGGGAHGPGW 1990 2000 2010 2020 2030 2040 1120 1130 1140 1150 1160 1170 mKIAA1 TVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPG ::::::::: .::::::::::::::::::::::::::::::::::::::::::.:::::: gi|194 TVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLVPGPEPG 2050 2060 2070 2080 2090 2100 1180 1190 1200 1210 1220 1230 mKIAA1 PQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPTLNQLKQTQKLHDMEA :::.::.::::::::::::::::::::::::::.:::::. .::.::::::::::::::: gi|194 PQPALHIQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGATPLKPSLNQLKQTQKLHDMEA 2110 2120 2130 2140 2150 2160 1240 1250 1260 1270 1280 mKIAA1 -------SGDARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPE---ACALPT ::.::: .. :.:.: ::::.:.:. :.. :::. :::::.: .: ::. gi|194 TAGWPLASGEARAMNTSRTAMGMPCLAPVPSPVPTVVIPGAASALPVPMPGTALSC-LPA 2170 2180 2190 2200 2210 1290 1300 1310 1320 1330 mKIAA1 PPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG :: gi|194 PPLGQYGSLIPAPVSWGPWAAQAGSRSLNAGPSLGAADAPALPVFFRPTVVSMPGPRLQI 2220 2230 2240 2250 2260 2270 >>gi|119583262|gb|EAW62858.1| WNK lysine deficient prote (2216 aa) initn: 4411 init1: 1669 opt: 4541 Z-score: 3419.2 bits: 645.7 E(): 9.7e-182 Smith-Waterman score: 6119; 68.897% identity (78.000% similar) in 1450 aa overlap (17-1283:776-2209) 10 20 30 40 mKIAA1 RRYLWPIFCSPQGWGTRPWTRPVHACLQGL--LAREMPQMPVVPPI .: : .: :: : . .:: .:::::: gi|119 PQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMP-QAPLQPLAQVPPQMPPIPVVPPI 750 760 770 780 790 800 50 60 70 80 90 100 mKIAA1 TPLTGLDGLPQTLTDLPAANVAPVPPPQYFSPAVILPSLTTPLP-TSPALPMQAVKLPHP :::.:.:::: .: :::.:.: :::::::::::::::::..::: .:::::.:::::::: gi|119 TPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHP 810 820 830 840 850 860 110 120 130 140 150 160 mKIAA1 PGTPLAVPCQTIVPNAPAAIPLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDI ::.:::.::.::::::::.:::::::: :::::::: ::::.:.:::::::::::.: :. gi|119 PGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDV 870 880 890 900 910 920 170 180 190 mKIAA1 PPSPHHTVQSLRATPPQLASP----VPPQPV---QPSVI--------------------- :::::::::..:::::: : : .::::: ::.. gi|119 PPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQP 930 940 950 960 970 980 200 210 mKIAA1 -----------------------HLPEQAAPTAASGTQ---------------------- ::::::::.:. :.: gi|119 MLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPV 990 1000 1010 1020 1030 1040 mKIAA1 ------------------------------------------------------------ gi|119 PPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGI 1050 1060 1070 1080 1090 1100 220 230 240 250 mKIAA1 ----------------EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEG ::.::::::: ::: ::.::::::::..:::::::.:::::::: gi|119 ASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCEGAFGGGRLEG 1110 1120 1130 1140 1150 1160 260 270 280 290 300 310 mKIAA1 RTARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDA :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDA 1170 1180 1190 1200 1210 1220 320 330 340 350 360 370 mKIAA1 PDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCG ::::::::::::::: ::::::::::::::::::::::::::::.::: :::::::.::: gi|119 PDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCG 1230 1240 1250 1260 1270 1280 380 390 400 410 420 430 mKIAA1 LATGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQ :.::::.:::::::::::::::::::::::::::::::: .. ::::::::::: ::::: gi|119 LGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLPLSSLPPEASQ 1290 1300 1310 1320 1330 1340 440 450 460 470 480 490 mKIAA1 DPAPYPDQLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIP---AAPAT : ::: :::: ..::: :.:::::::: :::::. :::::::::::. .: ::::: gi|119 DSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTA-LPQDGAAPAT 1350 1360 1370 1380 1390 1400 500 510 520 530 540 550 mKIAA1 STVPESAAGTAMQAGGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEAS ::.:: :.::: ::::::: :: .: :: ::::::. : ..::: .: .::::: ::. gi|119 STMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAA 1410 1420 1430 1440 1450 1460 560 570 580 590 600 610 mKIAA1 RCSTGLGEPISTREVSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQ :::..:. :::: .::::: .:. : . ::: : :: .:::.:::. : gi|119 ----------STRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQ 1470 1480 1490 1500 1510 620 630 640 650 660 670 mKIAA1 LPSPPLGPTAPPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAG :::::::::.:: ::::::::::::::::::::.:::::::::::::::::::::::::: gi|119 LPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAG 1520 1530 1540 1550 1560 1570 680 690 700 710 mKIAA1 TPMEASDRDFTLEPLRGD------------LPSALSDKTPSLTQQTQPSLEKSETAPAGW ::.:..:::::::::::: :: . .. . . .: :: .:::: ::. gi|119 TPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRG 1580 1590 1600 1610 1620 1630 720 730 740 750 760 770 mKIAA1 ALAQREQGASSPMTESSSSNTLGCDSDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQN :. :::.:: ::::: . :: : :. :::::: ..::::::. . :....: :.. gi|119 AVM--EQGTSSSMTESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRD 1640 1650 1660 1670 1680 1690 780 790 800 810 820 830 mKIAA1 SSVPREALAAPMQSGPGSFTVGSPA---QLRGARDSGSPHKRPGQQDNSSPAKTVGRFSV .. :. : : : : :::. : : ::: :::.::: ::: :::::::::::: gi|119 GGEAGESSAEPPPSDMG--TVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSV 1700 1710 1720 1730 1740 840 850 860 870 880 890 mKIAA1 VSTQDEWTLASPHSLRYSAPPDVYLDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDSG ::::::::::::::::::::::::::: ::::.:::::::.:::::::::: ::.::::: gi|119 VSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSG 1750 1760 1770 1780 1790 1800 900 910 920 930 940 950 mKIAA1 DERPRRRSQVQKQSSLPGTGGVASDFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTISI :: :: : ::::.::: .:.::.::::::::::.: :::::::::::::.:.::::::. gi|119 DEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISV 1810 1820 1830 1840 1850 1860 960 970 980 990 1000 1010 mKIAA1 TSFHSQSSYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKPL :::::::::::::::::.:::::::::.:::::::::::::::::::::::::::::::: gi|119 TSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPL 1870 1880 1890 1900 1910 1920 1020 1030 1040 1050 1060 1070 mKIAA1 PPNVGFFHTAPPMGRRRKTSKSKLKAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDPA :::::::::::: :::::::::::::::::::::.::::::::::::.:::::::.:::: gi|119 PPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPA 1930 1940 1950 1960 1970 1980 1080 1090 1100 1110 1120 mKIAA1 HAS---TPPGT----KAVQTQQPCSVRASLSTDICSGLASDGGGARGQGWTVYHPTSERG .:: : .: ::::::::::::::::.::::::::::::::::::::::::::: gi|119 QASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERV 1990 2000 2010 2020 2030 2040 1130 1140 1150 1160 1170 1180 mKIAA1 AYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPTLHVQAQ .::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|119 TYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQ 2050 2060 2070 2080 2090 2100 1190 1200 1210 1220 1230 1240 mKIAA1 VNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPTLNQLKQTQKLHDMEAS------GDA :::::::::::::::::::::::.:::::::.:::::::::::::.::::. :.: gi|119 VNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEA 2110 2120 2130 2140 2150 2160 1250 1260 1270 1280 1290 1300 mKIAA1 RATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPEACALPTPPCKFLSRPSSGQP :: ..:::.:: : :::::::::. :::.:.: :: :. gi|119 RAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDPESEKPD 2170 2180 2190 2200 2210 1310 1320 1330 mKIAA1 TEGRSISGGFHDTCPGGERGDENSLTPSG >>gi|119583264|gb|EAW62860.1| WNK lysine deficient prote (2210 aa) initn: 4474 init1: 1669 opt: 4523 Z-score: 3405.6 bits: 643.2 E(): 5.5e-181 Smith-Waterman score: 6120; 68.652% identity (77.755% similar) in 1461 aa overlap (17-1290:762-2206) 10 20 30 40 mKIAA1 RRYLWPIFCSPQGWGTRPWTRPVHACLQGL--LAREMPQMPVVPPI .: : .: :: : . .:: .:::::: gi|119 PQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMP-QAPLQPLAQVPPQMPPIPVVPPI 740 750 760 770 780 790 50 60 70 80 90 100 mKIAA1 TPLTGLDGLPQTLTDLPAANVAPVPPPQYFSPAVILPSLTTPLP-TSPALPMQAVKLPHP :::.:.:::: .: :::.:.: :::::::::::::::::..::: .:::::.:::::::: gi|119 TPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHP 800 810 820 830 840 850 110 120 130 140 150 160 mKIAA1 PGTPLAVPCQTIVPNAPAAIPLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDI ::.:::.::.::::::::.:::::::: :::::::: ::::.:.:::::::::::.: :. gi|119 PGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDV 860 870 880 890 900 910 170 180 190 mKIAA1 PPSPHHTVQSLRATPPQLASP----VPPQPV---QPSVI--------------------- :::::::::..:::::: : : .::::: ::.. gi|119 PPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQP 920 930 940 950 960 970 200 210 mKIAA1 -----------------------HLPEQAAPTAASGTQ---------------------- ::::::::.:. :.: gi|119 MLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPV 980 990 1000 1010 1020 1030 mKIAA1 ------------------------------------------------------------ gi|119 PPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGI 1040 1050 1060 1070 1080 1090 220 230 240 250 mKIAA1 ----------------EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEG ::.::::::: ::: ::.::::::::..:::::::.:::::::: gi|119 ASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCEGAFGGGRLEG 1100 1110 1120 1130 1140 1150 260 270 280 290 300 310 mKIAA1 RTARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDA :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDA 1160 1170 1180 1190 1200 1210 320 330 340 350 360 370 mKIAA1 PDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCG ::::::::::::::: ::::::::::::::::::::::::::::.::: :::::::.::: gi|119 PDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCG 1220 1230 1240 1250 1260 1270 380 390 400 410 420 430 mKIAA1 LATGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQ :.::::.:::::::::::::::::::::::::::::::: .. ::::::::::: ::::: gi|119 LGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLPLSSLPPEASQ 1280 1290 1300 1310 1320 1330 440 450 460 470 480 490 mKIAA1 DPAPYPDQLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIP---AAPAT : ::: :::: ..::: :.:::::::: :::::. :::::::::::. .: ::::: gi|119 DSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTA-LPQDGAAPAT 1340 1350 1360 1370 1380 500 510 520 530 540 550 mKIAA1 STVPESAAGTAMQAGGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEAS ::.:: :.::: ::::::: :: .: :: ::::::. : ..::: .: .::::: ::. gi|119 STMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAA 1390 1400 1410 1420 1430 1440 560 570 580 590 600 610 mKIAA1 RCSTGLGEPISTREVSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQ :::..:. :::: .::::: .:. : . ::: : :: .:::.:::. : gi|119 ----------STRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQ 1450 1460 1470 1480 1490 620 630 640 650 660 670 mKIAA1 LPSPPLGPTAPPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAG :::::::::.:: ::::::::::::::::::::.:::::::::::::::::::::::::: gi|119 LPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAG 1500 1510 1520 1530 1540 1550 680 690 700 710 mKIAA1 TPMEASDRDFTLEPLRGD------------LPSALSDKTPSLTQQTQPSLEKSETAPAGW ::.:..:::::::::::: :: . .. . . .: :: .:::: ::. gi|119 TPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRG 1560 1570 1580 1590 1600 1610 720 730 740 750 760 770 mKIAA1 ALAQREQGASSPMT-ESSSSNTLGCDSDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQ :. :::.:: :: ::: . :: : :. :::::: ..::::::. . :....: :. gi|119 AVM--EQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDR 1620 1630 1640 1650 1660 1670 780 790 800 810 820 830 mKIAA1 NSSVPREALAAPMQSGPGSFTVGSPA---QLRGARDSGSPHKRPGQQDNSSPAKTVGRFS ... :. : : : : :::. : : ::: :::.::: ::: ::::::::::: gi|119 DGGEAGESSAEPPPSDMG--TVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFS 1680 1690 1700 1710 1720 1730 840 850 860 870 880 890 mKIAA1 VVSTQDEWTLASPHSLRYSAPPDVYLDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDS :::::::::::::::::::::::::::: ::::.:::::::.:::::::::: ::.:::: gi|119 VVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDS 1740 1750 1760 1770 1780 1790 900 910 920 930 940 950 mKIAA1 GDERPRRRSQVQKQSSLPGTGGVASDFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTIS ::: :: : ::::.::: .:.::.::::::::::.: :::::::::::::.:.:::::: gi|119 GDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTIS 1800 1810 1820 1830 1840 1850 960 970 980 990 1000 1010 mKIAA1 ITSFHSQSSYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKP .:::::::::::::::::.:::::::::.::::::::::::::::::::::::::::::: gi|119 VTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKP 1860 1870 1880 1890 1900 1910 1020 1030 1040 1050 1060 1070 mKIAA1 LPPNVGFFHTAPPMGRRRKTSKSKLKAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDP ::::::::::::: :::::::::::::::::::::.::::::::::::.:::::::.::: gi|119 LPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDP 1920 1930 1940 1950 1960 1970 1080 1090 1100 1110 1120 mKIAA1 AHAS---TPPGT----KAVQTQQPCSVRASLSTDICSGLASDGGGARGQGWTVYHPTSER :.:: : .: ::::::::::::::::.::::::::::::::::::::::::::: gi|119 AQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSER 1980 1990 2000 2010 2020 2030 1130 1140 1150 1160 1170 1180 mKIAA1 GAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPTLHVQA .::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|119 VTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQA 2040 2050 2060 2070 2080 2090 1190 1200 1210 1220 1230 1240 mKIAA1 QVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPTLNQLKQTQKLHDMEAS------GD ::::::::::::::::::::::::.:::::::.:::::::::::::.::::. :. gi|119 QVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGE 2100 2110 2120 2130 2140 2150 1250 1260 1270 1280 1290 mKIAA1 ARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPEAC---ALPTPPCKFLSRPS ::: ..:::.:: : :::::::::. :::.:.: :: : .: :. :: gi|119 ARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPGSCGPRAVSTPTSYT 2160 2170 2180 2190 2200 2210 1300 1310 1320 1330 mKIAA1 SGQPTEGRSISGGFHDTCPGGERGDENSLTPSG >>gi|208965700|dbj|BAG72864.1| WNK lysine deficient prot (2210 aa) initn: 4474 init1: 1669 opt: 4523 Z-score: 3405.6 bits: 643.2 E(): 5.5e-181 Smith-Waterman score: 6120; 68.652% identity (77.755% similar) in 1461 aa overlap (17-1290:762-2206) 10 20 30 40 mKIAA1 RRYLWPIFCSPQGWGTRPWTRPVHACLQGL--LAREMPQMPVVPPI .: : .: :: : . .:: .:::::: gi|208 PQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMP-QAPLQPLAQVPPQMPPIPVVPPI 740 750 760 770 780 790 50 60 70 80 90 100 mKIAA1 TPLTGLDGLPQTLTDLPAANVAPVPPPQYFSPAVILPSLTTPLP-TSPALPMQAVKLPHP :::.:.:::: .: :::.:.: :::::::::::::::::..::: .:::::.:::::::: gi|208 TPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHP 800 810 820 830 840 850 110 120 130 140 150 160 mKIAA1 PGTPLAVPCQTIVPNAPAAIPLLAVAPQGVAALSIHPAVAQIPAQPVYPAAFPQMVPGDI ::.:::.::.::::::::.:::::::: :::::::: ::::.:.:::::::::::.: :. gi|208 PGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDV 860 870 880 890 900 910 170 180 190 mKIAA1 PPSPHHTVQSLRATPPQLASP----VPPQPV---QPSVI--------------------- :::::::::..:::::: : : .::::: ::.. gi|208 PPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQP 920 930 940 950 960 970 200 210 mKIAA1 -----------------------HLPEQAAPTAASGTQ---------------------- ::::::::.:. :.: gi|208 MLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPV 980 990 1000 1010 1020 1030 mKIAA1 ------------------------------------------------------------ gi|208 PPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGI 1040 1050 1060 1070 1080 1090 220 230 240 250 mKIAA1 ----------------EQVSQDKPPGPPQSSESFGGSDVTSGRDLSDSCEGTFGGGRLEG ::.::::::: ::: ::.::::::::..:::::::.:::::::: gi|208 ASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCEGAFGGGRLEG 1100 1110 1120 1130 1140 1150 260 270 280 290 300 310 mKIAA1 RTARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDA :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|208 RAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDA 1160 1170 1180 1190 1200 1210 320 330 340 350 360 370 mKIAA1 PDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSEDTDADHGSDTGTSPPHLGTCG ::::::::::::::: ::::::::::::::::::::::::::::.::: :::::::.::: gi|208 PDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCG 1220 1230 1240 1250 1260 1270 380 390 400 410 420 430 mKIAA1 LATGEENRQSQANAPVYQQNVLHTGKRWFIICPVAEHPATDTSESSPPLPLSSLQPEASQ :.::::.:::::::::::::::::::::::::::::::: .. ::::::::::: ::::: gi|208 LGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLPLSSLPPEASQ 1280 1290 1300 1310 1320 1330 440 450 460 470 480 490 mKIAA1 DPAPYPDQLSLTDKPSFPAAQQLLSQAGSSNPPGGASAPLAPSSPPVTTVIP---AAPAT : ::: :::: ..::: :.:::::::: :::::. :::::::::::. .: ::::: gi|208 DSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTA-LPQDGAAPAT 1340 1350 1360 1370 1380 500 510 520 530 540 550 mKIAA1 STVPESAAGTAMQAGGPGTHQGPASVHETLQPLAETRSAQCTAQPLSTGQGPCTPALEAS ::.:: :.::: ::::::: :: .: :: ::::::. : ..::: .: .::::: ::. gi|208 STMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAA 1390 1400 1410 1420 1430 1440 560 570 580 590 600 610 mKIAA1 RCSTGLGEPISTREVSTQGEPLPASVPEPSPPTGATQSVPGQPPPPLPITVGAISLAAPQ :::..:. :::: .::::: .:. : . ::: : :: .:::.:::. : gi|208 ----------STRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQ 1450 1460 1470 1480 1490 620 630 640 650 660 670 mKIAA1 LPSPPLGPTAPPPPPSALESDGEGPPPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAG :::::::::.:: ::::::::::::::::::::.:::::::::::::::::::::::::: gi|208 LPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAG 1500 1510 1520 1530 1540 1550 680 690 700 710 mKIAA1 TPMEASDRDFTLEPLRGD------------LPSALSDKTPSLTQQTQPSLEKSETAPAGW ::.:..:::::::::::: :: . .. . . .: :: .:::: ::. gi|208 TPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRG 1560 1570 1580 1590 1600 1610 720 730 740 750 760 770 mKIAA1 ALAQREQGASSPMT-ESSSSNTLGCDSDAGQVASDSSTAPSVPQDASGSSVPTHMDPKDQ :. :::.:: :: ::: . :: : :. :::::: ..::::::. . :....: :. gi|208 AVM--EQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDR 1620 1630 1640 1650 1660 1670 780 790 800 810 820 830 mKIAA1 NSSVPREALAAPMQSGPGSFTVGSPA---QLRGARDSGSPHKRPGQQDNSSPAKTVGRFS ... :. : : : : :::. : : ::: :::.::: ::: ::::::::::: gi|208 DGGEAGESSAEPPPSDMG--TVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFS 1680 1690 1700 1710 1720 1730 840 850 860 870 880 890 mKIAA1 VVSTQDEWTLASPHSLRYSAPPDVYLDEIPSSPEVKLAVRRVQTASSIEVGVEEPASSDS :::::::::::::::::::::::::::: ::::.:::::::.:::::::::: ::.:::: gi|208 VVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDS 1740 1750 1760 1770 1780 1790 900 910 920 930 940 950 mKIAA1 GDERPRRRSQVQKQSSLPGTGGVASDFVKKATAFLHRSSRAGSLGPETPSRAGVKVPTIS ::: :: : ::::.::: .:.::.::::::::::.: :::::::::::::.:.:::::: gi|208 GDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTIS 1800 1810 1820 1830 1840 1850 960 970 980 990 1000 1010 mKIAA1 ITSFHSQSSYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKP .:::::::::::::::::.:::::::::.::::::::::::::::::::::::::::::: gi|208 VTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKP 1860 1870 1880 1890 1900 1910 1020 1030 1040 1050 1060 1070 mKIAA1 LPPNVGFFHTAPPMGRRRKTSKSKLKAGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDP ::::::::::::: :::::::::::::::::::::.::::::::::::.:::::::.::: gi|208 LPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDP 1920 1930 1940 1950 1960 1970 1080 1090 1100 1110 1120 mKIAA1 AHAS---TPPGT----KAVQTQQPCSVRASLSTDICSGLASDGGGARGQGWTVYHPTSER :.:: : .: ::::::::::::::::.::::::::::::::::::::::::::: gi|208 AQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSER 1980 1990 2000 2010 2020 2030 1130 1140 1150 1160 1170 1180 mKIAA1 GAYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPTLHVQA .::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|208 VTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQA 2040 2050 2060 2070 2080 2090 1190 1200 1210 1220 1230 1240 mKIAA1 QVNNSNNKKGTFTDDLHKLVDEWTTKTVGAAQVKPTLNQLKQTQKLHDMEAS------GD ::::::::::::::::::::::::.:::::::.:::::::::::::.::::. :. gi|208 QVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGE 2100 2110 2120 2130 2140 2150 1250 1260 1270 1280 1290 mKIAA1 ARATSVPRAAVGASCLAPAPGPLSTTATPGATPALPVPIPEAC---ALPTPPCKFLSRPS ::: ..:::.:: : :::::::::. :::.:.: :: : .: :. :: gi|208 ARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPGSCGPRAVSTPTSYT 2160 2170 2180 2190 2200 2210 1300 1310 1320 1330 mKIAA1 SGQPTEGRSISGGFHDTCPGGERGDENSLTPSG 1332 residues in 1 query sequences 2727779818 residues in 7921681 library sequences Tcomplib [34.26] (2 proc) start: Sun Mar 15 18:40:08 2009 done: Sun Mar 15 18:50:18 2009 Total Scan time: 1311.990 Total Display time: 1.190 Function used was FASTA [version 34.26.5 April 26, 2007]