FASTA searches a protein or DNA sequence data bank version 3.4t11 Apr 17, 2002 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 ../query/mKIAA4188.ptfa, 402 aa vs ./tmplib.26680 library 1768615 residues in 2168 sequences Expectation_n fit: rho(ln(x))= 4.5289+/-0.00493; mu= 16.9935+/- 0.330 mean_var=123.2756+/-29.494, 0's: 0 Z-trim: 16 B-trim: 0 in 0/36 Lambda= 0.1155 FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2168) mKIAA1547 ( 897 res) mbg07188 ( 897) 2223 382 9.1e-107 mKIAA1261 ( 729 res) mfj34130 ( 729) 2123 365 8.5e-102 mKIAA4167 ( 342 res) mpj04828 ( 342) 209 45 6e-06 mKIAA1449 ( 675 res) mbg03116 ( 675) 195 44 4.3e-05 mKIAA4156 ( 368 res) mfj52041 ( 368) 171 39 0.0005 mKIAA1374 ( 446 res) mpj01605 ( 446) 148 36 0.0079 mKIAA1645 ( 384 res) mfj18213 ( 384) 146 35 0.0092 >>mKIAA1547 ( 897 res) mbg07188 (897 aa) initn: 2268 init1: 2051 opt: 2223 Z-score: 2009.1 bits: 381.8 E(): 9.1e-107 Smith-Waterman score: 2223; 77.206% identity (78.750% ungapped) in 408 aa overlap (3-402:490-897) 10 20 30 mKIAA4 GVPLTLSSPFTSSFSLGSHSTLNGDLSMPGSY :.::.: . . :.. :: .::.:. :..: mKIAA1 PTPGTSTTPGLRSMPGKPPGMDPIASALRTPITLTSSYPAPFAMMSHHEMNGSLTSPSAY 460 470 480 490 500 510 40 50 60 70 80 mKIAA4 VGLHLSP-QVSSSVV-----YGRSPLMAFESHPHLRGSSV--SLPGIPVAKPAYSFHVSA .::: : :.:.... :::::...:. :: .:.... :: .:: .:::::::::: mKIAA1 AGLHNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSA 520 530 540 550 560 570 90 100 110 120 130 140 mKIAA4 DGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGKGCVKVWDV :::::::::: :::.: ::::::::..::.:::::::::::. :.:::::::::::.::. mKIAA1 DGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDI 580 590 600 610 620 630 150 160 170 180 190 200 mKIAA4 GQPGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTS .:::::.:..::::::::::::::::::::..::::::::::.:::::.::::::::::: mKIAA1 SQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTS 640 650 660 670 680 690 210 220 230 240 250 260 mKIAA4 SAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLW :::::::::.::::::::::::::::.::::.::..::::::::::::::::: ::.:: mKIAA1 SAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLW 700 710 720 730 740 750 270 280 290 300 310 320 mKIAA4 TGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPEKY ::::::::: ::::::::::::::.:::::::.::. .:::::::::.::::: ::.:: mKIAA1 TGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKY 760 770 780 790 800 810 330 340 350 360 370 380 mKIAA4 QLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNK ::.:::::::::::: ::.::::::::::::::::::::::::::::::::::::: ..: mKIAA1 QLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDK 820 830 840 850 860 870 390 400 mKIAA4 YIVTGSGDKKATVYEVVY ::::::::::::::::.: mKIAA1 YIVTGSGDKKATVYEVIY 880 890 >>mKIAA1261 ( 729 res) mfj34130 (729 aa) initn: 2177 init1: 2052 opt: 2123 Z-score: 1919.9 bits: 365.0 E(): 8.5e-102 Smith-Waterman score: 2219; 76.399% identity (78.500% ungapped) in 411 aa overlap (3-402:319-729) 10 20 30 mKIAA4 GVPLTLSSPFTSSFSLGSHSTLNGDLSMPGS- :... :. . :.. :. .::.:. ::. mKIAA1 PTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAA 290 300 310 320 330 340 40 50 60 70 80 mKIAA4 YVGLH-LSPQVSSS-------VVYGRSPLMAFESHPHLRGSSV--SLPGIPVAKPAYSFH :.::: .:::.:.. ..:::::...:. : :.: .. .: ::: .::::::: mKIAA1 YAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFH 350 360 370 380 390 400 90 100 110 120 130 140 mKIAA4 VSADGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGKGCVKV ::::::::::::: :::.: ::::::::..:: :::::::::::. :.:::::::::::: mKIAA1 VSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKV 410 420 430 440 450 460 150 160 170 180 190 200 mKIAA4 WDVGQPGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAE ::...::.:.::.::::::::::::::.:::::..::::::::::::::::::::::::: mKIAA1 WDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAE 470 480 490 500 510 520 210 220 230 240 250 260 mKIAA4 LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGT ::::::::::::.:::.::::::::::::.::::.::..:::::::::::::::::. :: mKIAA1 LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGT 530 540 550 560 570 580 270 280 290 300 310 320 mKIAA4 RLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKP .::::::::::: ::::::::::::::.:::::::.::. .:::::::.:.:::::: :: mKIAA1 KLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKP 590 600 610 620 630 640 330 340 350 360 370 380 mKIAA4 EKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISR .::::.:::::::::::: ::.::::::::::::::::::::::::::::::::::::: mKIAA1 DKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISV 650 660 670 680 690 700 390 400 mKIAA4 NNKYIVTGSGDKKATVYEVVY ..:::::::::::::::::.: mKIAA1 DDKYIVTGSGDKKATVYEVIY 710 720 >>mKIAA4167 ( 342 res) mpj04828 (342 aa) initn: 180 init1: 124 opt: 209 Z-score: 199.1 bits: 45.5 E(): 6e-06 Smith-Waterman score: 211; 20.611% identity (21.344% ungapped) in 262 aa overlap (146-400:37-296) 120 130 140 150 160 170 mKIAA4 GEVVCAVTISSSTQHVYTGGKGCVKVWDVGQPGSKTPVAQLDCLNRDNYIRSCKLLPDGQ .: . . . .: ... : : :. :.:. mKIAA4 RANYRAGSMATEHLPAERAQSLLSAPRREEEPQKPNYALRLTLAGHSAAISSVKFSPNGE 10 20 30 40 50 60 180 190 200 210 220 230 mKIAA4 SLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDL : .. . . :: .: : : . . .: : :.. : .: .. :::. mKIAA4 WLASSAADALIIIW--GAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDM 70 80 90 100 110 120 240 250 260 270 280 290 mKIAA4 QNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFS .. .. ..::.: . : :.. .. . .:..:..:. :... :. :. . :. : . mKIAA4 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISA 130 140 150 160 170 180 300 310 320 330 340 350 mKIAA4 LGHCPNQDWLAVGMESSHVEVLHVRKPEKYQLRLHESC--VLSLKFASCGRWFVSTGKDN .. : . .. : .. .. . . . . :. : .::. :...... :: mKIAA4 VNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDN 190 200 210 220 230 240 360 370 380 390 400 mKIAA4 LLNAWRTPYG---ASIFQSKESSSVLSCDIS-RNNKYIVTGSGDKKATVYEVVY :. : : . :. . : ..: . :..:.:: :. . .... mKIAA4 TLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQR 250 260 270 280 290 300 mKIAA4 LQGHTDVVISAACHPTKNIIASAALENDKTIKVWSSDC 310 320 330 340 >>mKIAA1449 ( 675 res) mbg03116 (675 aa) initn: 151 init1: 151 opt: 195 Z-score: 183.7 bits: 43.6 E(): 4.3e-05 Smith-Waterman score: 195; 25.389% identity (27.374% ungapped) in 193 aa overlap (95-278:94-281) 70 80 90 100 110 120 mKIAA4 SVSLPGIPVAKPAYSFHVSADGQMQPVPFPSDALVGTGIPRHARQLHTL-AHGEVVCAVT ::. : . ... . :: .: . : :.. mKIAA1 DPYIASMEHHTDWVNDVVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALA 70 80 90 100 110 120 130 140 150 160 170 mKIAA4 ISSSTQHVYTGGKG-CVKVWDVGQ----PGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLI ... . : ..: . .:::. .:.. :. . . . : : . : .. mKIAA1 YAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIV 130 140 150 160 170 180 180 190 200 210 220 230 mKIAA4 VGGEASTLSIWDLAAPTPRIKAELTS---SAPACYALAVSPDAKVCFSCCSDGNIVVWDL :. ..: .:: :: :.: . . :: . :. :.: :::.: .: : mKIAA1 SGSTEKVLRVWD-----PRTCAKLMKLKGHTDNVKALLLHRDGTQCLSGSSDGTIRLWFL 190 200 210 220 230 240 250 260 270 280 290 mKIAA4 QNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSL .: . .. : .:. ....: :....:: : . : :::. mKIAA1 GQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLK 240 250 260 270 280 290 300 310 320 330 340 350 mKIAA4 GHCPNQDWLAVGMESSHVEVLHVRKPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLN mKIAA1 MELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKG 300 310 320 330 340 350 >>mKIAA4156 ( 368 res) mfj52041 (368 aa) initn: 111 init1: 111 opt: 171 Z-score: 164.6 bits: 39.2 E(): 0.0005 Smith-Waterman score: 194; 23.552% identity (25.311% ungapped) in 259 aa overlap (153-398:68-321) 130 140 150 160 170 180 mKIAA4 TISSSTQHVYTGGKGCVKVWDVGQPGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGE ::.. : :. : . :.:...: ... mKIAA4 PRPGPAPPLPSAAAAAAAMKLTDSVLRSFRVAKVFRENSDK-INCFDFSPNGETVISSSD 40 50 60 70 80 90 190 200 210 220 230 240 mKIAA4 ASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAK-VCFSCCS-DGNIVVWDLQNQAM ... ..: : : : :. . . . :. : .: . : .: .:... . mKIAA4 DDSIVLYDCQEGKP--KRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKY 100 110 120 130 140 150 250 260 270 280 290 mKIAA4 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGR-QLQQHDFSSQIFSLGHCP .: : ::. . ...: . .:.::.:.: :::: : .: .. . :. : mKIAA4 IRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFD--P 160 170 180 190 200 210 300 310 320 330 340 350 mKIAA4 NQDWLAVGMESSHVEVLHVRKPEK-----YQLRLHESCVLS-LKFASCGRW-FVSTGKD- . .:.:..: :.. .:. .: .... ..: . :::.. :. ..::. . mKIAA4 EGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSF 220 230 240 250 260 270 360 370 380 390 400 mKIAA4 -NLLNAWRTPYGASIFQSKESSSV-LSCDISRNNKYIVTGSGDKKATVYEVVY :..:.. .. .:..: : ... ....:. :: : : :.. mKIAA4 IRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVL 280 290 300 310 320 330 mKIAA4 DGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD 340 350 360 >>mKIAA1374 ( 446 res) mpj01605 (446 aa) initn: 47 init1: 47 opt: 148 Z-score: 143.1 bits: 35.5 E(): 0.0079 Smith-Waterman score: 148; 25.899% identity (28.346% ungapped) in 139 aa overlap (173-307:124-254) 150 160 170 180 190 200 mKIAA4 DVGQPGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAEL .: .:.. :: . ..:: . : ... : mKIAA1 GKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIW---SKTGMLRSTL 100 110 120 130 140 150 210 220 230 240 250 260 mKIAA4 TSSAPACYALAVSPDA-KVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGT .... :..: .::. :: .. . .... :: .: : :...: .: .. . mKIAA1 AQQGTPVYSVAWGPDSEKVLYT--AGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVND 160 170 180 190 200 270 280 290 300 310 mKIAA4 RLWTGGLDNTVRCWDLREGRQL---QQHDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHV . ..: : . :: :: : : :. : :.. :. . .::: mKIAA1 LILSAGEDCKYKVWD-SYGRVLYGSQPHEHP--ITSVAWAPDGELFAVGSFHTLRLCDKT 210 220 230 240 250 260 320 330 340 350 360 370 mKIAA4 RKPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCD mKIAA1 GWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVEQRWEWKNFQVTLTKRRTM 270 280 290 300 310 320 >>mKIAA1645 ( 384 res) mfj18213 (384 aa) initn: 115 init1: 69 opt: 146 Z-score: 141.9 bits: 35.1 E(): 0.0092 Smith-Waterman score: 168; 22.552% identity (25.249% ungapped) in 337 aa overlap (49-357:50-378) 20 30 40 50 60 70 mKIAA4 HSTLNGDLSMPGSYVGLHLSPQVSSSVVYGRSPLMAFESH-----PHLRGSSVSLPGIPV ::: :: .: : : : : mKIAA1 GGVAVGSCPRKKPLCLVFSSGASDPGGPSWRSPRTAF-THMAALFPPPPGPRFVLRGTQS 20 30 40 50 60 70 80 90 100 110 120 mKIAA4 AKPAYSFHVSADGQMQPVPFPS--DALVGTGIPRHARQLHTL-AHGE--VVCAVTISSST : . : ... .:. : . ..:: . : . :: .:: :. :. .. mKIAA1 AVNTLHFCPPSQAAGNPLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGQGVIWLKTLPQGH 80 90 100 110 120 130 130 140 150 160 170 180 mKIAA4 QHVYTGGKGCVKVWDVGQPGSKTPVAQLDCLNRDNYIRSCK--LLPDGQS---LIVGGEA : . : . .::. . : .: .: .. :. . :. .: ::. : : :.. mKIAA1 QLLSQGRDLRLCLWDL-EEGRNTI---MDSVQLDS-VGFCRGSILVRGQQCWMLAVPGKG 140 150 160 170 180 190 190 200 210 220 230 mKIAA4 ST-LSIWDLAAPTP----RIKAELTSSAPACYALAVSPDA--KVCFSCCSDGNIVVWDLQ : ..: .. . : . .:. . : : .: . .. . .. ::....::.. mKIAA1 SDEVQILEMPSKTSVCTLKPEADARPGMPMCLGLWQTNSSLRPLLLAGYEDGSVTLWDIS 200 210 220 230 240 250 240 250 260 270 280 290 mKIAA4 NQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ---QHDFSSQ-I .. . :. : . . .:... .. .:. ... :.: . ..:: :.... : mKIAA1 ERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELTNPGI 260 270 280 290 300 310 300 310 320 330 340 350 mKIAA4 FSLGHCPNQDWLAVGMESSHVEVLHVR--KPEKYQLRLHESCVLSLKFASCGRWFVSTGK . :.. ::.. . ...:.: : :: : .: . : . ::. : ... .: mKIAA1 AEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAV-LAFHSAPVYCVAFAADG-LLAAGSK 320 330 340 350 360 370 360 370 380 390 400 mKIAA4 DNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY :. .. : mKIAA1 DQRISIWSLYPCP 380 402 residues in 1 query sequences 1768615 residues in 2168 library sequences Scomplib [34t11] start: Mon Mar 27 11:04:29 2006 done: Mon Mar 27 11:04:30 2006 Scan time: 0.610 Display time: 0.100 Function used was FASTA [version 3.4t11 Apr 17, 2002]