FASTA searches a protein or DNA sequence data bank
version 3.4t11 Apr 17, 2002
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
../query/mKIAA4060.ptfa, 1035 aa
vs ./tmplib.26680 library
1767982 residues in 2168 sequences
Expectation_n fit: rho(ln(x))= 5.1291+/-0.00503; mu= 17.9955+/- 0.337
mean_var=121.0922+/-28.124, 0's: 0 Z-trim: 13 B-trim: 0 in 0/36
Lambda= 0.1166
FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 39, opt: 27, open/ext: -10/-2, width: 16
The best scores are: opt bits E(2168)
mKIAA1346 ( 998 res) mfj09039 ( 998) 1377 243 1.2e-64
mKIAA2029 ( 1233 res) meh00056 (1233) 1329 235 3.7e-62
mKIAA0688 ( 893 res) mbh00872 ( 893) 1083 194 8.7e-50
mKIAA0605 ( 402 res) mpf03178 ( 402) 331 67 6.3e-12
mKIAA1233 ( 747 res) mbp17192 ( 747) 285 60 1.9e-09
mKIAA0550 ( 612 res) mbg18962 ( 612) 263 56 2.2e-08
mKIAA1445 ( 632 res) mph02187 ( 632) 250 54 1e-07
mKIAA4089 ( 1251 res) mbg12616 (1251) 210 47 1.7e-05
mKIAA1312 ( 276 res) mpm12339 ( 276) 158 38 0.0029
mKIAA0960 ( 1668 res) mbg08685 (1668) 165 40 0.0037
mKIAA1679 ( 1608 res) meh02165 (1608) 161 39 0.0058
>>mKIAA1346 ( 998 res) mfj09039 (998 aa)
initn: 930 init1: 272 opt: 1377 Z-score: 1252.8 bits: 243.4 E(): 1.2e-64
Smith-Waterman score: 1534; 30.738% identity (34.208% ungapped) in 976 aa overlap (5-916:57-997)
10 20
mKIAA4 VRTDAQGRLVSHVVSLETAGA-------GVRARR
..: : .:.. : :. :...:
mKIAA1 GCGAMQPKVPLGSRKQKPCSDMGDVQRAARSRGSLSAHMLLLLLASITMLLCARGAHGRP
30 40 50 60 70 80
30 40 50 60 70 80
mKIAA4 AALDQTSGLPGGAAQDPG---GRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQGETGD
. :. ::. . :: : .::..:::.:.:.. ..::: :.. :..
mKIAA1 TEEDEELVLPS-LERAPGHDSTTTRLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPG
90 100 110 120 130 140
90 100 110 120 130
mKIAA4 TRVEPL-----LGSCLYVGDVADLPKASSVALSNCDGLAGLIRMEEEEFFIEPLEKGQTD
.... : :. :.: : : : .:..::: :.:. : . .. :::::.: :.
mKIAA1 SEAQHLDPTGDLAHCFYSGTVNGDP-GSAAALSLCEGVRGAFYLQGEEFFIQPAPGVATE
150 160 170 180 190 200
140 150 160 170
mKIAA4 Q------EAEQG---RVHVVYRR------------PPTPKPPPVSEPQALDTGVSQGNLD
. : :.. . :.. :: : :.:.. .: . :
mKIAA1 RLAPAVPEEESSARPQFHILRRRRRGSGGAKCGVMDDETLPTSDSRPESQNTRNQWPVRD
210 220 230 240 250 260
180 190 200 210 220 230
mKIAA4 SLSRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNI
. : . .: :. .: ... : .:..: .:.:...:::. ...:::::...
mKIAA1 PTPQDAG--KPSGPGSIRK-KRFVSSPRY-VETMLVADQSMADFHGS-GLKHYLLTLFSV
270 280 290 300 310
240 250 260 270 280 290
mKIAA4 VNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHD
. ..:. :. :..:.:.:... . .. . .: . .:.: : : ...:.
mKIAA1 AARFYKHPSIRNSISLVVVKILVIYEEQKGPEVT-SNAALTLRNFCNWQKQHNSPSDRDP
320 330 340 350 360 370
300 310 320 330 340 350
mKIAA4 EYHDHAIFLTRQDFGPS---GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVL
:..: ::..::::. : :.: : .: : :::.. ..::...::..::: :::.
mKIAA1 EHYDTAILFTRQDLCGSHTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVF
380 390 400 410 420 430
360 370 380 390 400 410
mKIAA4 GMEHDGQGNRCG--DEVRLGS-IMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLRDD
.: :: ....:. . : : .:: .... : :: :: .. .: . .:: :
mKIAA1 NMPHD-DAKHCASLNGVTGDSHLMASMLSSLDHSQPWSPCSAYMVTSFLDNGHGECLMDK
440 450 460 470 480 490
420 430 440 450 460
mKIAA4 PFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CK
: .. ::. ::: :. :.::.: :: : . : :::. .. . :.
mKIAA1 P--QNPIKLPSDLPGTLYDANRQCQFTFGEESKHCPDAAS--TCTTLWCTGTSGGLLVCQ
500 510 520 530 540 550
470 480 490 500 510 520
mKIAA4 TKKGPPLDGTMCAPGKHCFKGHCIWLTPDI----LKRDGNWGAWTPFGSCSRTCGTGVKF
::. : ::: :. :: : .:.:. : :. :.:: : :.:.:::::: ::..
mKIAA1 TKHFPWADGTSCGEGKWCVSGKCVNKT-DMKHFATPVHGSWGPWGPWGDCSRTCGGGVQY
560 570 580 590 600 610
530 540 550 560 570 580
mKIAA4 RTRQCDNPHPANGGRTCSGLAYDFQLCNPQDCP-NSLADFREEQCQQWDLYFE--HGDVQ
:.:::: : :::. : : .. :: .::: :. ::::::. . . . :.
mKIAA1 TMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEP
620 630 640 650 660 670
590 600 610 620 630
mKIAA4 H-HWLP-HEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVG
.: : . . :.::.: ::.: : .. : ::: :: :. :.::.:.: :.:
mKIAA1 TVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAG
680 690 700 710 720 730
640 650 660 670 680 690
mKIAA4 CDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEAD-
:: .: :.:. ::::::::... :: ..: : . . : . ::::: .. ... .
mKIAA1 CDRIIDSKKKFDKCGVCGGNGSTCKKMSGIVTST--RPGYHDIVTIPAGATNIEVKHRNQ
740 750 760 770 780
700 710 720 730 740 750
mKIAA4 ----TTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRNEDER-ETLQTIGPL
... :... . : .::: . :. ... :. .: . . : .....::
mKIAA1 RGSRNNGSFLAIRAAD-GTYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPL
790 800 810 820 830 840
760 770 780 790 800 810
mKIAA4 HGTITVLVIPEGDT-RISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCG
. .:. :. : . : .. . :.... . . . .. ::....:. ::: ::
mKIAA1 KEPLTIQVLMVGHALRPKIKFTYFMKKKTESFNAIPTFS------EWVIEEWGECSKTCG
850 860 870 880 890 900
820 830 840 850 860 870
mKIAA4 GGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCG
.: : :: : . . :. .:: : : : : : : .:.: ::...::
mKIAA1 SGWQRRVVQCR---DINGHPASECAKEVKP-ASTRPCADLPC--PHWQVGDWSPCSKTCG
910 920 930 940 950
880 890 900 910 920 930
mKIAA4 RTGMQVRSVRCIQPLHNNTTRSVHTKHCND-HRPESR-RACNRELCPGRWRAGSWSQCSV
. :.. :...:.. :.. . : .. :. ..:. :. :
mKIAA1 K-GYKKRTLKCVS--HDGGVLS--NESCDPLKKPKHYIDFCTLTQCS
960 970 980 990
940 950 960 970 980 990
mKIAA4 TCGNGTQERPVLCRTADDNFGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPD
>>mKIAA2029 ( 1233 res) meh00056 (1233 aa)
initn: 827 init1: 313 opt: 1329 Z-score: 1208.2 bits: 235.4 E(): 3.7e-62
Smith-Waterman score: 1856; 32.820% identity (36.510% ungapped) in 1039 aa overlap (4-986:76-1065)
10 20 30
mKIAA4 VRTDAQGRLVSHVVSLETAGAGVRARRAALDQT
: .: ::: . : :: :. :
mKIAA2 GSPEDPQPPPFSGSSWLETGEYDLVSAYEVDHRGDYVSH----DIMHYQRRRRRRAVTQ-
50 60 70 80 90 100
40 50 60 70 80 90
mKIAA4 SGLPGGAAQDPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQGETGDTRVE--PLL
::: : : : .:::: :. . :.::: :. :. : :. :
mKIAA2 ---PGGDA------LHLRLKGPRHDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPPE
110 120 130 140 150
100 110 120 130 140
mKIAA4 GSCLYVGDVADLPKASSVALSNCDGLAGLIRMEEEEFFIEPLEKGQTDQ--EAEQGR--V
.:.: :.. . . ::::::.:.:: :.:: .. ..:..:: :.. .. ::
mKIAA2 ENCFYQGSLRSQGN-SSVALSTCQGLLGMIRTKDTDYFLKPLPPHLTSKLNRSAQGDSPS
160 170 180 190 200 210
150 160 170 180
mKIAA4 HVVYRRPPTPKPPPVSE------------PQ----ALDTGVSQGNLDSLSRA--------
::.:.: . : .: :. . : :: . :
mKIAA2 HVLYKRSTERQAPRENEVLMITRKRDLARPHLHHDNFHLGPSQKQHFCGRRKKYMPQPPN
220 230 240 250 260 270
190 200 210 220 230
mKIAA4 --LGVLEERINSSRRRVR---RHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNI
: .: .. . : :. : . ... :.:.:. :: ...: ::.:.. :.::..:.
mKIAA2 DDLYILPDEYKPSSRHKRSLLKSHRNEELNVETLVVVDRKMMQSHGHENITTYVLTILNM
280 290 300 310 320 330
240 250 260 270 280 290
mKIAA4 VNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRW-AYLQQKPDTDH
:. ...: ..:..::.:.: .::: . .: . ...: . :.: . :. : :
mKIAA2 VSALFKDGTIGGNINIVIVGLILLEDEQP-GLAISHHADHTLTSFCQWQSGLMGKDGT--
340 350 360 370 380
300 310 320 330 340 350
mKIAA4 DEYHDHAIFLTRQDFG-----PSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETG
:::::.:: :. : :.::..::: ::::.:...:.. ::..:::.:
mKIAA2 --RHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTVNEDSGLGLAFTIAHESG
390 400 410 420 430 440
360 370 380 390 400 410
mKIAA4 HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYD--CLRDD
: .:: :::.:: : . :.::.: . . : :: ::.: : ..: . . :: :.
mKIAA2 HNFGMVHDGEGNMC--KKSEGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQ
450 460 470 480 490 500
420 430 440 450 460
mKIAA4 PF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTA-FRTFDPCKQLWCSHPDNPYFCK
: .... .::: :. : ::...:: .: :: : :: ::: . :.
mKIAA2 PKPVKEYKYPEKLPGQLYDANTQCKWQFGEKAKLCMLDFRK-DICKALWCHRIGRK--CE
510 520 530 540 550 560
470 480 490 500 510 520
mKIAA4 TKKGPPLDGTMCAPGKHCFKGHCIWLTPDILK-RDGNWGAWTPFGSCSRTCGTGVKFRTR
:: : .::.:. : :.:. . : :.:. :.:.. :::::: :.. : :
mKIAA2 TKFMPAAEGTLCGQDMWCRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGISHRDR
570 580 590 600 610 620
530 540 550 560 570 580
mKIAA4 QCDNPHPANGGRTCSGLAYDFQLCNPQDCPNSLADFREEQCQQWDLYFEHGDVQHHWLPH
: ::.:..::. :.: . ..::: : :: . .::: :: ... .: . ..: :.
mKIAA2 LCTNPRPSHGGKFCQGSTRTLKLCNSQRCPLDSVDFRAAQCAEYNSKRFRGWL-YKWKPY
630 640 650 660 670
590 600 610 620 630 640
mKIAA4 EHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSR
. . .. :.::: .. :.. :.::: :: .:. ..:. : :..::::.:.::
mKIAA2 TQLEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCS-EDSRNVCIDGMCERVGCDNVLGSD
680 690 700 710 720 730
650 660 670 680 690 700
mKIAA4 KQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTSHHLSVK
::.:::: :.:. : . .: ... ..: .: ::.::: . : :.. .. ..::.
mKIAA2 ATEDSCGVCKGNNSDCVTHRGLYSKHHSTNQYYHMVTIPSGARSIHIYETNISTSYISVR
740 750 760 770 780 790
710 720 730 740 750 760
mKIAA4 NLETGKFILNEENHLD-PNSRSFIAMGVEWEY-RNEDERETLQTIGPLHGTITVLVIPEG
: .. :: . .: :. .: :. ..: :. : :.: . :: . :. : .. .:
mKIAA2 N-SLKRYYLNGHWSVDWPGRYKF--SGATFNYKRSYKEPENLTSPGPTNETLIVELLFQG
800 810 820 830 840 850
770 780 790 800 810 820
mKIAA4 DTRISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRR
. ...... :: . . . ::. . : :: ::::.. .: :: :
mKIAA2 RNP-GVAWEF-----SLPRSGAKKTPAAQPSYSWAIVR-SECSVSCGGGKMNSKAGCYRD
860 870 880 890 900
830 840 850 860 870 880
mKIAA4 LDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQ
: :. .::. ..: . :. . : . : .:.: :...:: : : : ::: .
mKIAA2 LKVP-VNASFCNPKTRPVTGLVPCKVSPCPSS-WSVGNWSVCSRTCG-GGTQSRPVRCTR
910 920 930 940 950 960
890 900 910 920 930 940
mKIAA4 PLHNNTTRSVHTKHCNDHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRT
: .:. .. : . .: ..::: . :: : .: :..:: :::.: ..: : :..
mKIAA2 RAHYRD-ESIPASLCPQPEPPIHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKS
970 980 990 1000 1010 1020
950 960 970 980 990
mKIAA4 ADDNF-------GVCREE-RPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQK
.. . .: : .:.: .:: : : .. :: .:::
mKIAA2 TNPSARAQLLHDTACTSEPKPRTHEICLLKRCHKH-----KK---LQWLVSAWSQCSVTC
1030 1040 1050 1060 1070
1000 1010 1020 1030
mKIAA4 ISSSNRPVYNSASALQCMPCALWSLPWAPLLFLYGKLP
mKIAA2 QGGTQQRVLRCAEKYISGKYRELASKKCLHLPKPDLELERACGLIPCPKHPPFDASGSPR
1080 1090 1100 1110 1120 1130
>>mKIAA0688 ( 893 res) mbh00872 (893 aa)
initn: 791 init1: 249 opt: 1083 Z-score: 986.1 bits: 193.9 E(): 8.7e-50
Smith-Waterman score: 1221; 32.606% identity (36.080% ungapped) in 779 aa overlap (30-777:124-858)
10 20 30 40 50
mKIAA4 VRTDAQGRLVSHVVSLETAGAGVRARRAALDQTSGLPGGAAQDPGGRLFYNLTVFGRDL
:. .: :::... :. ::.: : .::. :
mKIAA0 RRLLLLAFLLSLAWPASPLPREEEIVFPEKLNGSSILPGSGV--PA-RLLYRLPAFGEML
100 110 120 130 140 150
60 70 80 90 100 110
mKIAA4 HLRLRPNARLVAPGATVEWQGETGDTR--VEPLLGSCLYVGDVADLPKASSVALSNCDG-
:.:. . . . : ::.. :.. . .:: :. : .: . :. ::: . ::
mKIAA0 LLELEQDPGVQVEGLTVQYLGQAPEMLGGAEP--GTYL-TGTINGDPE--SVASLHWDGG
160 170 180 190 200
120 130 140 150 160 170
mKIAA4 -LAGLIRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRPPTPKPPPVSEPQALDTGVSQG
: :..... :. ..::: : .. . : .:.. :. :. . :. .: .:
mKIAA0 ALLGVLQYRGAELHLQPLEGGALNSAGGPG-AHILRRKSPASSQGPMCTVKA-----PSG
210 220 230 240 250
180 190 200 210 220 230
mKIAA4 NLDSLSRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTL
. . .:: :..: :. . . .:.:. .::... ::: ...::::.
mKIAA0 SPSPISR--------------RTKRFASLSRF-VETLVVADDKMAAFHGT-GLKRYLLTV
260 270 280 290 300
240 250 260 270 280 290
mKIAA4 MNIVNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAYLQQKPDT
: . . .. :. .:.:..:... :. . .. : . . . : :
mKIAA0 MAAAAKAFKHPSIRNPVNLVVTRLVIGPARKGPKWGQV--PPRPYAASAPGSG-ASTPLT
310 320 330 340 350 360
300 310 320 330 340 350
mKIAA4 DHDEYHDHAIFLTRQDF-GPS--GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETG
. ::..::::. : : :.: : .: :.:::.. ..::..:::..::: :
mKIAA0 TQILTTLTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELG
370 380 390 400 410 420
360 370 380 390 400
mKIAA4 HVLGMEHDGQG---NRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL-HSYD-CL
::..: ::.. : :. .:::.. . . :: :: . .. .: ..: ::
mKIAA0 HVFNMLHDNSKPCTNLNGQGGSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCL
430 440 450 460 470 480
410 420 430 440 450 460
mKIAA4 RDDPFAH-DWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCS-HPDNPY
: : : :: .:: :. ..::.. :: : . :: :::: : ..
mKIAA0 LDKPEAPLHLPAT--FPGKDYDADRQCQLTFGPDSSHCPQLPP--PCAALWCSGHLNGHA
490 500 510 520 530
470 480 490 500 510 520
mKIAA4 FCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILK-----RDGNWGAWTPFGSCSRTCGT
.:.::..: ::: :. .. :. :.:. . : :: . :.:: : :.:.::::::
mKIAA0 MCQTKHSPWADGTPCGSSQACMGGRCLHV--DQLKDFNVPQAGGWGPWGPWGDCSRTCGG
540 550 560 570 580 590
530 540 550 560 570
mKIAA4 GVKFRTRQCDNPHPANGGRTCSGLAYDFQLCNPQDCPNSLA-DFREEQCQQW----DLYF
::.: .:.: : : :::. : : :. :: ..::.. : :::::: . :: :
mKIAA0 GVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTENCPHGSALTFREEQCAAYNHRTDL-F
600 610 620 630 640 650
580 590 600 610 620 630
mKIAA4 EHGDVQHHWLPHEHRDA-KERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGD
. :.:. : ...:.: :... : .. : ::: :: :. :.::.:
mKIAA0 KSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCS-PDTSSVCVQGR
660 670 680 690 700 710
640 650 660 670 680 690
mKIAA4 CRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLI
: ..::: .:::.:. ::: :::::...:. .:.: . . : . ::::: :.:.
mKIAA0 CIHAGCDRIIGSKKKFDKCMVCGGDGSRCSKQSGSFKKF--RYGYSDVVTIPAGATHILV
720 730 740 750 760 770
700 710 720 730 740
mKIAA4 QE---ADTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMG-VEWEYRNEDE-RETLQT
.. . : .:..: : :.. :: : : :. . . : : .: . :::.
mKIAA0 RQQGGSGLKSIYLALK-LSDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSG
780 790 800 810 820
750 760 770 780 790 800
mKIAA4 IGPLHGTITVLVIPEGDTR-ISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCS
::: .:. :. :. . : :....
mKIAA0 HGPLAQPLTLQVLVAGNPQNARLRYSFFVPRPVPSTPRPPPQDWLQRRAEILKILRKRPW
830 840 850 860 870 880
>>mKIAA0605 ( 402 res) mpf03178 (402 aa)
initn: 308 init1: 129 opt: 331 Z-score: 306.5 bits: 67.0 E(): 6.3e-12
Smith-Waterman score: 372; 27.928% identity (30.097% ungapped) in 222 aa overlap (798-1016:191-399)
770 780 790 800 810 820
mKIAA4 RISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLD
.:... :.::: :: : . . :. :
mKIAA0 DIRCSEDEKLCDPSTKPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-D
170 180 190 200 210
830 840 850 860 870 880
mKIAA4 SKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQPL
...: .. :.. .:: ::. :. ..: :.. .:: :. .::: :.. : : :.. :
mKIAA0 GRVVPESQCQTETKPLAIH-PCGDKNCPAH-WLAQDWERCNTTCGR-GVKKRLVLCME-L
220 230 240 250 260 270
890 900 910 920 930 940
mKIAA4 HNNTTRSVHTKHCN-DHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTA
:. . .:. ..: . .: .. : .: .. ::.:. ::: :.. : : : .
mKIAA0 ANGKPQIRSGPECGLARKPPEESTCFERPCF-KWYTSPWSECTKTCGVGVRMRDVKCYQG
280 290 300 310 320 330
950 960 970 980 990 1000
mKIAA4 DDNFGVCREE-RPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQ-KISSSNRP
: : .: . : : ::: . : : .. .: . . :.. ..
mKIAA0 TDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQD-------QPGTNCALAIKVNLCGHW
340 350 360 370 380
1010 1020 1030
mKIAA4 VYNSASALQCMPCALWSLPWAPLLFLYGKLP
:..: .: :
mKIAA0 YYSKACCRSCRPPHS
390 400
>>mKIAA1233 ( 747 res) mbp17192 (747 aa)
initn: 397 init1: 155 opt: 285 Z-score: 261.8 bits: 59.6 E(): 1.9e-09
Smith-Waterman score: 305; 28.431% identity (33.333% ungapped) in 204 aa overlap (851-1033:478-672)
830 840 850 860 870 880
mKIAA4 GCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRS
::: : :.: :. .:: :....
mKIAA1 KAAFPKVQKTRVLQAPRSRINSNNLTGKSLPQE---HFWEPGNWTHCSATCGPLGVRLQR
450 460 470 480 490 500
890 900 910 920 930
mKIAA4 VRCIQPLHNNTTRSVHTKHCNDHR-P-ESRRACNRELCPGRWRAGSWSQCSVTCGNGTQE
::.. ....... :. :: : . ..:: . ::.:: .. ::.:::.::.: .
mKIAA1 PRCVMASGQEVSEAL----CGPHRKPLAGFQSCNIRDCPARWFTSVWSECSVSCGEGFHS
510 520 530 540 550 560
940 950 960 970 980
mKIAA4 RPVLCRTADDNFGV-------CR-EERPETARICRLAPCPRNGSDPSKK--SYVVQWLSR
: : :. . : : : ..:: . : . :: ... ::... . . .:
mKIAA1 RQVTCKQTKANGTVQVVSPRACAPKDRPLGRKPCSIRPCVQQAIDPGNQCPGRCMGHATR
570 580 590 600 610 620
990 1000 1010 1020 1030
mKIAA4 -PDPDSPIQKISSSN------RPVYNSASALQCMPC-ALWSL-PWAPLLFLYGKLP
. . :::. ::... .: :: : : . :: : . :.
mKIAA1 MQHHHTACAHNSSSSDCEDGRRPAFGRNCTLG--PCEACWRVGPWKPCTAVCGRGFQSRK
630 640 650 660 670
mKIAA1 VDCIHTGSCKIVADRYCVQVKPAAWRHCFGPSCDRNCTDTTHYCMFVKHLNLCSLAVYRQ
680 690 700 710 720 730
>>mKIAA0550 ( 612 res) mbg18962 (612 aa)
initn: 124 init1: 124 opt: 263 Z-score: 242.7 bits: 55.8 E(): 2.2e-08
Smith-Waterman score: 325; 35.676% identity (43.421% ungapped) in 185 aa overlap (798-973:158-318)
770 780 790 800 810 820
mKIAA4 RISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLD
::. .:: :: :: ::: : ..
mKIAA0 RPRSVHEKRVPQEQADAAKFMAQTGESGVEEWS--QWSACSVTCGQGSQVRTRTC---VS
130 140 150 160 170 180
830 840 850 860 870 880
mKIAA4 SKMVHRAFCSALAKPKAIRRACNPQE-CS-QPVWVTGEWEP---CTQSCGRTGMQVRSVR
.: ::. : :.:: : . :: :: : :. .::: :...:.
mKIAA0 PYGTH---CSG---PLRESRVCNNTALCPVHGVWE--EWSPWSLCSFTCGR-GQRTRTRS
190 200 210 220 230
890 900 910 920 930
mKIAA4 CIQPLHNNTTRSVHTKHCNDHRPESR-RACNRELCP--GRWRA-GSWSQCSVTCGNGTQE
: : ... . :. ::.. . :: ::: :.:. .:::.:::::.::::.
mKIAA0 CTPPQYGG-------RPCEG--PETHHKPCNIALCPVDGQWQEWSSWSHCSVTCSNGTQQ
240 250 260 270 280
940 950 960 970 980 990
mKIAA4 RPVLCRTADDNFGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQKI
: : .: . . :: :. : : : ::.
mKIAA0 RSRQCTAAAHGGSECRGPWAES-RECYNPECTANGQWNQWGHWSGCSKSCDGGWERRMRT
290 300 310 320 330 340
1000 1010 1020 1030
mKIAA4 SSSNRPVYNSASALQCMPCALWSLPWAPLLFLYGKLP
mKIAA0 CQGAAVTGQQCEGTGEEVRRCSEQRCPAPYEICPEDYLISMVWKRTPAGDLAFNQCPLNA
350 360 370 380 390 400
>>mKIAA1445 ( 632 res) mph02187 (632 aa)
initn: 354 init1: 249 opt: 250 Z-score: 230.8 bits: 53.6 E(): 1e-07
Smith-Waterman score: 274; 23.485% identity (32.461% ungapped) in 528 aa overlap (452-970:101-491)
430 440 450 460 470 480
mKIAA4 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMC-
::..: :: : . . :
mKIAA1 NMSLWIQNITTCPVRNVTRDGGFGPWSPWKPCEHL---DGDNSGSCLCR------ARSCD
80 90 100 110 120
490 500 510 520 530
mKIAA4 APGKHCFKGHCIWLTPDI----LKRDGNWGAWTPFGSCSRTCGTGVKFRTRQCDNPHPAN
.: .: .: : :.: .:.: : ::. ...:: .:: : . : :.:.:: : .
mKIAA1 SPRPRCGGLEC--LGPSIHIANCSRNGAWTAWSSWAQCSTSCGIGFQVRQRSCSNPAPRH
130 140 150 160 170
540 550 560 570 580 590
mKIAA4 GGRTCSGLAYDFQLCNPQDCPNSLADFREEQCQQWDLYFEHGDVQHHWLPHEHRDAKERC
::: : : . . ..:: .. : . : : . :. : .:
mKIAA1 GGRICVGKSREERFCN-ENTPCPVPIF-------WASW---GS----W---------SKC
180 190 200 210
600 610 620 630 640 650
mKIAA4 HLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVC
: : : : .: ..:. : :: :: : : .:
mKIAA1 SNNC----GGGVQSRRRSCENGNSCP----------------GC-GV------EFK--TC
220 230 240
660 670 680 690 700 710
mKIAA4 GGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTSHHLSVKNLETGKFIL
. . : :. . .: .. . .::: :: .: .
mKIAA1 NPEA--CPEVRRNTPWTP----WLPVNVTQGGAR----QEQ---------------RFRF
250 260 270 280
720 730 740 750 760 770
mKIAA4 NEENHL-DPNSRSFIAMGVEWEYRNEDERETLQTIGPLHGTITVLVIPEGDTRISLTYKY
. . : ::.. .: .:.: : :: . . :. .
mKIAA1 TCRAPLPDPHGLQF------------GKRRTETRTCPADGTGAC----DTDALV------
290 300 310
780 790 800 810 820 830
mKIAA4 MIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAF
:: : ... .. :. :: ::. : : . : : .. :
mKIAA1 ---EDLLRSGSTSPHTLNGGWATWG--PWSSCSRDCELGFRVRKRTC-----TNPEPRNG
320 330 340 350 360
840 850 860 870 880 890
mKIAA4 CSALAKPKAIRRACNPQECS-QPVWVT-GEWEPCTQSCGRTGMQVRSVRCIQPLHNNTTR
. : . :::: : . .: : :. ::: : :. : .: .
mKIAA1 GLPCVGDAAEYQDCNPQACPVRGAWSCWTAWSQCSASCG-GGHYQRTRSCTSP-----AP
370 380 390 400 410 420
900 910 920 930 940 950
mKIAA4 SVHTKHC-NDHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDNFGV
: : . : :. :. . :: : ::. .: .:.: : :. . :.
mKIAA1 SPGEDICLGLHTEEA--LCSTQACPEGWSL--WSEWGVCTEDGAQSRSRSCEELLPGPGA
430 440 450 460 470
960 970 980 990 1000 1010
mKIAA4 CREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQKISSSNRPVYNSASAL
: . .. :::
mKIAA1 CVGNSSQSR------PCPYSEIPVILPASSVEETTSCGGFNLIHLIVTGVSCFLVSGLLT
480 490 500 510 520 530
>>mKIAA4089 ( 1251 res) mbg12616 (1251 aa)
initn: 289 init1: 139 opt: 210 Z-score: 191.2 bits: 47.3 E(): 1.7e-05
Smith-Waterman score: 283; 31.088% identity (37.975% ungapped) in 193 aa overlap (793-973:18-187)
770 780 790 800 810 820
mKIAA4 PEGDTRISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGC
: . .::. :: ::. :: : : . :
mKIAA4 AAAVWVPISPDWTGPTGDPAAEEWS--PWSVCSSTCGEGWQTRTHFC
10 20 30 40
830 840 850 860 870
mKIAA4 RRRLDSKMVHRAFCSALAKPKAIRRACNPQE-CS-QPVWVTGEWEP---CTQSCGRTGMQ
: .. . . : .: :: . : . .: :: : :...::: :..
mKIAA4 --------VSSSYSTQCSGPLREQRLCNNSAVCPVHGAW--DEWSPWSLCSSTCGR-GFR
50 60 70 80 90
880 890 900 910 920 930
mKIAA4 VRSVRCIQPLHNNTTRSVHTKHCNDHRPESR-RACNRELCPGR-----WRA-GSWSQCSV
:. : : ... :. ::.. . :: ::::: : .::: ::.
mKIAA4 DRTRTCRPPQFGGNP-------CEG--PEKQTKFCNIALCPGRAVDGNWNEWSSWSTCSA
100 110 120 130 140
940 950 960 970 980 990
mKIAA4 TCGNGTQERPVLCRTADDNFGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPD
.:..: :.: : . . . :. . :: : : : :: .:.
mKIAA4 SCSQGRQQRTRECNGPSYGGAECQGHWVET-RDCFLQQCPVDGKWQAWASWGSCSVTCGG
150 160 170 180 190 200
1000 1010 1020 1030
mKIAA4 PDSPIQKISSSNRPVYNSASALQCMPCALWSLPWAPLLFLYGKLP
mKIAA4 GSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDNFGAVVWKETPAGEVA
210 220 230 240 250 260
>>mKIAA1312 ( 276 res) mpm12339 (276 aa)
initn: 315 init1: 136 opt: 158 Z-score: 151.0 bits: 37.7 E(): 0.0029
Smith-Waterman score: 361; 28.774% identity (37.423% ungapped) in 212 aa overlap (796-971:8-206)
770 780 790 800 810 820
mKIAA4 DTRISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRR
: .: . .:.::: :: :... .:: .
mKIAA1 RNAQSIPRTQWRFGSWTPCSATCGKGTRMRYVSCRDE
10 20 30
830 840 850 860 870 880
mKIAA4 LDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQ
:.... .. :..: :: : .. :. :.: : . .: :. .::. : .:.: :.
mKIAA1 -DGSVADESACATLPKPVA-KEECSVTPCGQ--WKALDWSSCSVTCGQ-GKATRQVVCV-
40 50 60 70 80 90
890 900 910
mKIAA4 PLHNNTTRSVHTKHCN-DHRPESRRACNRELCP---------------------------
: . . . ..:. :. ::. . :. ::
mKIAA1 ---NYSDHVIDRSECDPDYIPETDQDCSMSPCPQWTGLAHPFQNEDFRPRSDSPSRTHVL
100 110 120 130 140
920 930 940 950 960
mKIAA4 --GRWRAGSWSQCSVTCGNGTQERPVLCR-----TADDNFGVCREE-RPETARICRLAPC
..::.: :. :: ::..:.:.: :.:. ::.: : :. .:. : :. .::
mKIAA1 GGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTAND----CVERIKPDEQRACESGPC
150 160 170 180 190 200
970 980 990 1000 1010 1020
mKIAA4 PRNGSDPSKKSYVVQWLSRPDPDSPIQKISSSNRPVYNSASALQCMPCALWSLPWAPLLF
:.
mKIAA1 PQWAYGSWGECTKLCGGGMRTRLVVCQRANGDRFPDLSCEVLDKPTDREQCNTHACPQDA
210 220 230 240 250 260
>>mKIAA0960 ( 1668 res) mbg08685 (1668 aa)
initn: 255 init1: 109 opt: 165 Z-score: 149.0 bits: 39.9 E(): 0.0037
Smith-Waterman score: 298; 21.074% identity (25.000% ungapped) in 503 aa overlap (508-985:792-1240)
480 490 500 510 520 530
mKIAA4 TMCAPGKHCFKGHCIWLTPDILKRDGNWGAWTPFGSCSRTCGTGVKFRTRQ-CDNPHPAN
::: : : .:.. ..:: :::
mKIAA0 KKCPESLRPETVRPCLLPCRKDCVVTPYSDWTPCPSSCREGDSGARKQSRQRVIIQLPAN
770 780 790 800 810 820
540 550 560 570 580 590
mKIAA4 GGRTCSGLAYDFQLCN-PQDCPN-SLADFREEQCQ--QWDLYFEHGDVQHHWLPHEHRDA
::. :: :. . :. : : . . ..:: :.. . .:. : :.:
mKIAA0 GGKECSDPLYEEKACEAPPTCHSYRWKTHKWRRCQLVPWSIQQDVPGAQEGCGPG--RQA
830 840 850 860 870
600 610 620 630 640 650
mKIAA4 KERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDK
. . :.... :.. .. . . : . .: .. . ::. . : .. ..
mKIAA0 RA---ITCRKQDGGQASIQECLQYAGPVPALTQACQIPCQDDCQ-------FTSWSKFSS
880 890 900 910 920
660 670 680 690 700 710
mKIAA4 C-GVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTSHHLSVKNLET
: : ::. :. ... : .: .:. . : ::. . ...
mKIAA0 CNGDCGAVRTRKRAIVG---KSKKKEKCKNSHLYP------LIETQYCPCDKYNAQP---
930 940 950 960 970
720 730 740 750 760 770
mKIAA4 GKFILNEENHLDPNSRSFIAMGVEWEYRNEDERETLQTIGPLHGTITVLVIPEGDTRISL
. : . . :.... . .:.. . : .: : : . ... . . :.
mKIAA0 ---VGNWSDCILPEGKAEVLLGMKVQG---DSKECGQ--GYRYQAMACY---DQNGRLVE
980 990 1000 1010 1020
780 790 800 810 820
mKIAA4 TYKYMIHEDSLNVDDNNVLE--DDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSK
: . : ... .. .: ::. .:: ::: ::.: . . :.. .
mKIAA0 TSRCNSHG---YIEEACIIPCPSDCKLSEWS--NWSRCSKSCGSGVKVRSKWLREKPYNG
1030 1040 1050 1060 1070 1080
830 840 850 860 870 880
mKIAA4 MVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCT-------QSCGRTGMQVRSVR
. . . .. . . ..:.: .::: : : ..::. :.:.:.::
mKIAA0 GRPCPKLDHVNQAQVYEVVPCHSDCNQYIWVTEPWSVCKVTFVDMRDNCGE-GVQTRKVR
1090 1100 1110 1120 1130 1140
890 900 910 920 930
mKIAA4 CIQPLHNNTTRSVHTKHCN-DHRPESRRACNRELCP-----GRWRAGSWSQCSVTCG-NG
:.: .. .. :. :. . : . : :. :: ..: : :. :.. :. .:
mKIAA0 CMQNTADGPSEHVEDYLCDPEDMPLGSRECKLP-CPEDCVISEW--GPWT-CALPCNPSG
1150 1160 1170 1180 1190
940 950 960 970 980 990
mKIAA4 TQER---PVLCRTADDNFGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPD
...: :. : :. .: :.... :: : . :..:
mKIAA0 SRQRSADPI--RQPADEGRAC----PDAVEK---EPCSLNKNCYHYDYNVTDWSTCQLSE
1200 1210 1220 1230 1240
1000 1010 1020 1030
mKIAA4 SPIQKISSSNRPVYNSASALQCMPCALWSLPWAPLLFLYGKLP
mKIAA0 KAVCGNGIKTRMLDCVRSDGKSVDLKYCEELGLEKNWPMNTSCTVECPVNCQLSDWSSWS
1250 1260 1270 1280 1290 1300
1035 residues in 1 query sequences
1767982 residues in 2168 library sequences
Scomplib [34t11]
start: Mon Mar 27 11:00:39 2006 done: Mon Mar 27 11:00:40 2006
Scan time: 0.990 Display time: 0.510
Function used was FASTA [version 3.4t11 Apr 17, 2002]