# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mbg14564.fasta.nr -Q ../query/mKIAA0351.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2
FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
mKIAA0351, 537 aa
vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library
2727779818 residues in 7921681 sequences
statistics sampled from 60000 to 7918898 sequences
Expectation_n fit: rho(ln(x))= 5.2389+/-0.000186; mu= 11.9434+/- 0.010
mean_var=77.9676+/-15.044, 0's: 27 Z-trim: 39 B-trim: 119 in 1/67
Lambda= 0.145250
FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 37, opt: 25, open/ext: -10/-2, width: 16
The best scores are: opt bits E(7921681)
gi|123232349|emb|CAM22216.1| Ral GEF with PH domai ( 497) 3303 701.7 1.2e-199
gi|49119059|gb|AAH72656.1| Ralgps1 protein [Mus mu ( 515) 2942 626.1 7.6e-177
gi|114626729|ref|XP_520267.2| PREDICTED: Ral GEF w ( 537) 2838 604.3 2.8e-170
gi|194386776|dbj|BAG61198.1| unnamed protein produ ( 537) 2825 601.6 1.9e-169
gi|7637906|gb|AAF65253.1|AF221098_1 Ral guanine nu ( 529) 2758 587.5 3.1e-165
gi|114626731|ref|XP_001146563.1| PREDICTED: Ral GE ( 529) 2758 587.5 3.1e-165
gi|194033600|ref|XP_001924716.1| PREDICTED: simila ( 327) 2072 443.6 4.1e-122
gi|119611433|gb|EAW91027.1| Ral GEF with PH domain ( 514) 1938 415.7 1.6e-113
gi|114568156|ref|XP_001155146.1| PREDICTED: hypoth ( 512) 1891 405.8 1.5e-110
gi|123232348|emb|CAM22215.1| Ral GEF with PH domai ( 584) 1780 382.6 1.7e-103
gi|189040174|sp|A2AR50.2|RGPS1_MOUSE RecName: Full ( 585) 1780 382.6 1.7e-103
gi|148676648|gb|EDL08595.1| Ral GEF with PH domain ( 625) 1780 382.6 1.8e-103
gi|194671264|ref|XP_873225.3| PREDICTED: similar t ( 557) 1769 380.3 7.9e-103
gi|189040074|sp|Q5JS13.1|RGPS1_HUMAN RecName: Full ( 557) 1761 378.6 2.5e-102
gi|109112220|ref|XP_001096712.1| PREDICTED: simila ( 623) 1761 378.6 2.8e-102
gi|148676646|gb|EDL08593.1| Ral GEF with PH domain ( 593) 1756 377.6 5.5e-102
gi|73968199|ref|XP_851594.1| PREDICTED: similar to (1114) 1757 378.0 7.7e-102
gi|126294172|ref|XP_001366247.1| PREDICTED: simila ( 560) 1722 370.4 7.4e-100
gi|126294169|ref|XP_001366195.1| PREDICTED: simila ( 587) 1716 369.2 1.8e-99
gi|123235634|emb|CAM25543.1| Ral GEF with PH domai ( 225) 1544 332.8 6.2e-89
gi|189040075|sp|B0UXH6.1|RGPS1_DANRE RecName: Full ( 581) 1530 330.2 9.8e-88
gi|148921675|gb|AAI46737.1| Ralgps1 protein [Danio ( 581) 1530 330.2 9.8e-88
gi|114626735|ref|XP_001146412.1| PREDICTED: Ral GE ( 384) 1481 319.8 8.8e-85
gi|55664149|emb|CAH72699.1| Ral GEF with PH domain ( 305) 1478 319.1 1.1e-84
gi|21708078|gb|AAH33708.1| RALGPS1 protein [Homo s ( 384) 1478 319.2 1.4e-84
gi|21595579|gb|AAH32372.1| RALGPS1 protein [Homo s ( 305) 1475 318.5 1.8e-84
gi|75076849|sp|Q4R7W3.1|RGPS2_MACFA RecName: Full= ( 557) 1350 292.5 2.1e-76
gi|114568150|ref|XP_001155326.1| PREDICTED: hypoth ( 557) 1350 292.5 2.1e-76
gi|221043740|dbj|BAH13547.1| unnamed protein produ ( 557) 1349 292.3 2.5e-76
gi|114568152|ref|XP_001155200.1| PREDICTED: hypoth ( 551) 1333 288.9 2.5e-75
gi|110645343|gb|AAI18720.1| LOC779506 protein [Xen ( 474) 1329 288.0 4e-75
gi|111493975|gb|AAI05627.1| Ralgps2 protein [Rattu ( 351) 1324 286.9 6.6e-75
gi|55663144|emb|CAH71098.1| Ral GEF with PH domain ( 548) 1316 285.3 3e-74
gi|114568154|ref|XP_001154765.1| PREDICTED: hypoth ( 485) 1312 284.5 4.8e-74
gi|119608053|gb|EAW87647.1| Ral GEF with PH domain ( 438) 1311 284.2 5.2e-74
gi|74750518|sp|Q86X27.1|RGPS2_HUMAN RecName: Full= ( 583) 1312 284.5 5.5e-74
gi|114568142|ref|XP_514026.2| PREDICTED: hypotheti ( 583) 1312 284.5 5.5e-74
gi|149707917|ref|XP_001498602.1| PREDICTED: Ral GE ( 583) 1312 284.5 5.5e-74
gi|126306457|ref|XP_001373960.1| PREDICTED: simila ( 604) 1311 284.3 6.6e-74
gi|149636309|ref|XP_001515657.1| PREDICTED: simila ( 692) 1311 284.4 7.3e-74
gi|26331700|dbj|BAC29580.1| unnamed protein produc ( 555) 1307 283.5 1.1e-73
gi|26325020|dbj|BAC26264.1| unnamed protein produc ( 523) 1305 283.0 1.4e-73
gi|148707423|gb|EDL39370.1| Ral GEF with PH domain ( 541) 1305 283.0 1.4e-73
gi|29144890|gb|AAH43132.1| Ralgps2 protein [Mus mu ( 564) 1305 283.0 1.5e-73
gi|12858423|dbj|BAB31312.1| unnamed protein produc ( 568) 1305 283.1 1.5e-73
gi|148707424|gb|EDL39371.1| Ral GEF with PH domain ( 582) 1305 283.1 1.5e-73
gi|26329225|dbj|BAC28351.1| unnamed protein produc ( 590) 1305 283.1 1.5e-73
gi|172045898|sp|Q9ERD6.2|RGPS2_MOUSE RecName: Full ( 590) 1305 283.1 1.5e-73
gi|11321424|gb|AAG34162.1|AF312924_1 Ral-A exchang ( 590) 1305 283.1 1.5e-73
gi|30851698|gb|AAH52663.1| Ralgps2 protein [Mus mu ( 590) 1296 281.2 5.7e-73
>>gi|123232349|emb|CAM22216.1| Ral GEF with PH domain an (497 aa)
initn: 3303 init1: 3303 opt: 3303 Z-score: 3740.3 bits: 701.7 E(): 1.2e-199
Smith-Waterman score: 3303; 100.000% identity (100.000% similar) in 497 aa overlap (41-537:1-497)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|123 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110 120 130
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFAELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 SCDYASKSYDAVVFDVLKVTPEEFAELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVR
40 50 60 70 80 90
140 150 160 170 180 190
mKIAA0 EILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 EILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKD
100 110 120 130 140 150
200 210 220 230 240 250
mKIAA0 KTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 KTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENE
160 170 180 190 200 210
260 270 280 290 300 310
mKIAA0 QRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 QRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIE
220 230 240 250 260 270
320 330 340 350 360 370
mKIAA0 PGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 PGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNKG
280 290 300 310 320 330
380 390 400 410 420 430
mKIAA0 RLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVPTMEGPLRRKTLLKEGRKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 RLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVPTMEGPLRRKTLLKEGRKP
340 350 360 370 380 390
440 450 460 470 480 490
mKIAA0 ALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 ALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF
400 410 420 430 440 450
500 510 520 530
mKIAA0 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPANLMSFE
:::::::::::::::::::::::::::::::::::::::::::::::
gi|123 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPANLMSFE
460 470 480 490
>>gi|49119059|gb|AAH72656.1| Ralgps1 protein [Mus muscul (515 aa)
initn: 2094 init1: 1761 opt: 2942 Z-score: 3331.3 bits: 626.1 E(): 7.6e-177
Smith-Waterman score: 3235; 96.117% identity (96.311% similar) in 515 aa overlap (41-537:1-515)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|491 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPN
::::::::::::::::::::::::: ::::::::::::::::::
gi|491 SCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPN
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|491 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
gi|491 APIFRLTKTWAPLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|491 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|491 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
280 290 300 310 320 330
360 370 380 390 400 410
mKIAA0 TPPVPRHRKSHSLGN-KGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVP
::::::::::::::: .:::::::::::::::::::::::::::::::::::::::::::
gi|491 TPPVPRHRKSHSLGNNRGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVP
340 350 360 370 380 390
420 430 440 450 460 470
mKIAA0 TMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|491 TMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVS
400 410 420 430 440 450
480 490 500 510 520 530
mKIAA0 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|491 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPAN
460 470 480 490 500 510
mKIAA0 LMSFE
:::::
gi|491 LMSFE
>>gi|114626729|ref|XP_520267.2| PREDICTED: Ral GEF with (537 aa)
initn: 2084 init1: 1751 opt: 2838 Z-score: 3213.2 bits: 604.3 E(): 2.8e-170
Smith-Waterman score: 3131; 93.874% identity (96.047% similar) in 506 aa overlap (41-528:1-506)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|114 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPN
::::::::::::::::::::::::: ::::::::::::::::::
gi|114 SCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPN
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
gi|114 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDL
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
:::::::::::::::::::::::::::::::::::::::.:::: :::::::::::::::
gi|114 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLP
280 290 300 310 320 330
360 370 380 390 400 410
mKIAA0 TPPVPRHRKSHSLGN-KGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVP
::::::::::::::: .:::::::::::::::::::::::::::::.:: :..:.::.::
gi|114 TPPVPRHRKSHSLGNNRGRLYATLGPNWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVP
340 350 360 370 380 390
420 430 440 450 460 470
mKIAA0 TMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVS
::::::::::::::::::::::::::::.:::.:::::::::::::::::::::::::::
gi|114 TMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVS
400 410 420 430 440 450
480 490 500 510 520 530
mKIAA0 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
gi|114 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGA
460 470 480 490 500 510
mKIAA0 LMSFE
gi|114 APGPTGTDSHEVDHLEGGMGKEAGPCA
520 530
>>gi|194386776|dbj|BAG61198.1| unnamed protein product [ (537 aa)
initn: 2071 init1: 1738 opt: 2825 Z-score: 3198.5 bits: 601.6 E(): 1.9e-169
Smith-Waterman score: 3118; 93.676% identity (95.850% similar) in 506 aa overlap (41-528:1-506)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|194 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPN
::::::::::::::::::::::::: ::::::::::::::::::
gi|194 SCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPN
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|194 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
gi|194 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRGYIRSLKMVPSIPYLGIYLLDL
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
gi|194 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDRLTTLPHVQKYLKSVRYIEE
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
:::::::::::::::::::::::::::::::::::::::.:::: :::::::::::::::
gi|194 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLP
280 290 300 310 320 330
360 370 380 390 400 410
mKIAA0 TPPVPRHRKSHSLGN-KGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVP
::::::::::::::: .:::::::::::::::::::::::::::::.:: :..:.::.::
gi|194 TPPVPRHRKSHSLGNNRGRLYATLGPNWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVP
340 350 360 370 380 390
420 430 440 450 460 470
mKIAA0 TMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVS
::::::::::::::::::::::::::::.:::.:::::::::::::::::::::::::::
gi|194 TMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVS
400 410 420 430 440 450
480 490 500 510 520 530
mKIAA0 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
gi|194 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGA
460 470 480 490 500 510
mKIAA0 LMSFE
gi|194 APGPTGTDSHEVDHLEGGAGKEAGPCA
520 530
>>gi|7637906|gb|AAF65253.1|AF221098_1 Ral guanine nucleo (529 aa)
initn: 2507 init1: 1751 opt: 2758 Z-score: 3122.7 bits: 587.5 E(): 3.1e-165
Smith-Waterman score: 3051; 92.292% identity (94.466% similar) in 506 aa overlap (41-528:1-498)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|763 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPN
::::::::::::::::::::::::: ::::::::::::::::::
gi|763 SCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPN
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|763 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
gi|763 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDL
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|763 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
:::::::::::::::::::::::::::::::::::::::.:::: :::::::::::::::
gi|763 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLP
280 290 300 310 320 330
360 370 380 390 400 410
mKIAA0 TPPVPRHRKSHSLGN-KGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVP
::::::::::::::: .:::::::::::::::::::::::::::::.:: :..:.::.::
gi|763 TPPVPRHRKSHSLGNNRGRLYATLGPNWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVP
340 350 360 370 380 390
420 430 440 450 460 470
mKIAA0 TMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVS
::::::::::::::::::::::::::::.:::.::::::::::::::::: ::
gi|763 TMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKH--------VS
400 410 420 430 440
480 490 500 510 520 530
mKIAA0 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
gi|763 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGA
450 460 470 480 490 500
mKIAA0 LMSFE
gi|763 APGPTGTDSHEVDHLEGGAGKEAGPCA
510 520
>>gi|114626731|ref|XP_001146563.1| PREDICTED: Ral GEF wi (529 aa)
initn: 2507 init1: 1751 opt: 2758 Z-score: 3122.7 bits: 587.5 E(): 3.1e-165
Smith-Waterman score: 3051; 92.292% identity (94.466% similar) in 506 aa overlap (41-528:1-498)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|114 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPN
::::::::::::::::::::::::: ::::::::::::::::::
gi|114 SCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPN
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
gi|114 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDL
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
:::::::::::::::::::::::::::::::::::::::.:::: :::::::::::::::
gi|114 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLP
280 290 300 310 320 330
360 370 380 390 400 410
mKIAA0 TPPVPRHRKSHSLGN-KGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVP
::::::::::::::: .:::::::::::::::::::::::::::::.:: :..:.::.::
gi|114 TPPVPRHRKSHSLGNNRGRLYATLGPNWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVP
340 350 360 370 380 390
420 430 440 450 460 470
mKIAA0 TMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVS
::::::::::::::::::::::::::::.:::.::::::::::::::::: ::
gi|114 TMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKH--------VS
400 410 420 430 440
480 490 500 510 520 530
mKIAA0 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
gi|114 IVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGA
450 460 470 480 490 500
mKIAA0 LMSFE
gi|114 APGPTGTDSHEVDHLEGGMGKEAGPCA
510 520
>>gi|194033600|ref|XP_001924716.1| PREDICTED: similar to (327 aa)
initn: 2068 init1: 2068 opt: 2072 Z-score: 2348.7 bits: 443.6 E(): 4.1e-122
Smith-Waterman score: 2072; 95.541% identity (98.726% similar) in 314 aa overlap (224-537:14-327)
200 210 220 230 240 250
mKIAA0 FEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRS
: :::::::::::::::::::::::::::
gi|194 MAEEEALLAVELHPKDGIYLLDLIYIDSAYPASGSIMENEQRS
10 20 30 40
260 270 280 290 300 310
mKIAA0 NQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|194 NQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGS
50 60 70 80 90 100
320 330 340 350 360 370
mKIAA0 SSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNKGRLY
::::::::::::::::.::::::: :::::::.:::::::::::::::::::::::::::
gi|194 SSPRLVSSKEDLAGPSTGSSSARFSRRPTCPDASVAGSLPTPPVPRHRKSHSLGNKGRLY
110 120 130 140 150 160
380 390 400 410 420 430
mKIAA0 ATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVPTMEGPLRRKTLLKEGRKPALS
:::::::::::::::::::::::::.:: ::.::::.:::::::::::::::::::::::
gi|194 ATLGPNWRVPVRNSPRTRSCVYSPTGPCICTLGSSAAVPTMEGPLRRKTLLKEGRKPALS
170 180 190 200 210 220
440 450 460 470 480 490
mKIAA0 SWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLN
:::::::.:::.::::::::::::::::::::::::::..::::::::::::::::::::
gi|194 SWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVNVVGWMVQLPDDPEHPDIFQLN
230 240 250 260 270 280
500 510 520 530
mKIAA0 NPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQVPANLMSFE
:::::::::::::::::::::::::::::::.::::::::::::
gi|194 NPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE
290 300 310 320
>>gi|119611433|gb|EAW91027.1| Ral GEF with PH domain and (514 aa)
initn: 2102 init1: 972 opt: 1938 Z-score: 2194.2 bits: 415.7 E(): 1.6e-113
Smith-Waterman score: 2042; 62.548% identity (81.467% similar) in 518 aa overlap (45-537:5-514)
20 30 40 50 60 70
mKIAA0 PGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDY
:: .:: ..... . ::::.:: .. .
gi|119 MDLMNGQASSVNIAATASEKSSSSESLSDKGSEL
10 20 30
80 90 100 110
mKIAA0 ASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPNVVAF
.::.::::::::::::::.: ::.::::.::::.: :::.:::
gi|119 -KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 TRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIF
:::::.:::::::::: :::::::::.:::..: :::: ::::::.::.:::.:::::::
gi|119 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 RLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYID
:::::::::.::::::::::.:.::::::::: :::: ::::.: :::::::: :: :::
gi|119 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 SAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKF
::::..:::.::::::: ::::::::.::: :: :: . ::::::::.::.::::::::
gi|119 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYD-IPMLPHVQKYLNSVQYIEELQKF
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 VEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSL-P-TP
::::::::::.::::.:.:: ..:.:::.:: .:.: :. .... :.: : ::
gi|119 VEDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRK-----SVAAEGALLPQTP
280 290 300 310 320
360 370 380 390 400
mKIAA0 PVPR------HRKSHSLGNKGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSA
: :: ::: :::: :.::: .::: :: .::. :.. . : . .:
gi|119 PSPRNLIPHGHRKCHSLGYKNRLYHSLGPVTRV-ARNGYRSHMKASSSAESEDLAVHLYP
330 340 350 360 370 380
410 420 430 440 450 460
mKIAA0 TVPTMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGK
. :..: ::::::::::.::...:::.::..: :. :.::.::::..:.:::.::: .:
gi|119 GAVTIQGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNK
390 400 410 420 430 440
470 480 490 500 510 520
mKIAA0 KVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQV
.::..::::.. :::::::.: :.. .::: ::::.:.:..:.:: :::. ::.:.. ::
gi|119 NVSVIGWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQV
450 460 470 480 490 500
530
mKIAA0 PANLMSFE
:.:::.::
gi|119 PTNLMTFE
510
>>gi|114568156|ref|XP_001155146.1| PREDICTED: hypothetic (512 aa)
initn: 1622 init1: 972 opt: 1891 Z-score: 2141.0 bits: 405.8 E(): 1.5e-110
Smith-Waterman score: 1991; 61.950% identity (79.732% similar) in 523 aa overlap (45-537:5-512)
20 30 40 50 60 70
mKIAA0 PGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDY
:: .:: ..... . ::::.:: .. .
gi|114 MDLMNGQASSVNTAATASEKSSSSESLSDKGSEL
10 20 30
80 90 100 110
mKIAA0 ASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPNVVAF
.::.::::::::::::::.: ::.::::.::::.: :::.:::
gi|114 -KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 TRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIF
:::::.:::::::::: :::::::::.:::..: :::: ::::::.::.:::.:::::::
gi|114 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 RLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYID
:::::::::.::::::::::.:.::::::::: :::: ::::.: :::::::: :: :::
gi|114 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 SAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKF
::::..:::.::::::: ::::::::.::: :: :: . ::::::::.::.::::::::
gi|114 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYD-IPMLPHVQKYLNSVQYIEELQKF
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 VEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSL-P-TP
::::::::::.::::.:.:: ..:.:::.:: .:.: :. .... :.: : ::
gi|114 VEDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRK-----SVAAEGALLPQTP
280 290 300 310 320
360 370 380 390 400
mKIAA0 PVPR------HRKSHSLG-NKGRLYATLGPNWRVPVRNSPRTRSC----VYSPTSPCTCT
: :: ::: :::: :..::: .::: :: .::. :: : :: . .
gi|114 PSPRNLIPHGHRKCHSLGYNRNRLYHSLGPVTRV-ARNGYRTLMCSFLRYYSSAESEDLA
330 340 350 360 370 380
410 420 430 440 450 460
mKIAA0 VGSSATVPTMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYK
: . :..: ::::::::::.::...:::.::..: :. :.::.::::..:.:::
gi|114 VHLYPGAVTIQGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKH--
390 400 410 420 430 440
470 480 490 500 510 520
mKIAA0 STPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKS
.::.:::::.. :::::::.: :.. .::: ::::.:.:..:.:: :::. ::.:
gi|114 -----NVSVVGWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQS
450 460 470 480 490
530
mKIAA0 SRPQVPANLMSFE
.. :::.:::.::
gi|114 NKQQVPTNLMTFE
500 510
>>gi|123232348|emb|CAM22215.1| Ral GEF with PH domain an (584 aa)
initn: 3272 init1: 1770 opt: 1780 Z-score: 2014.6 bits: 382.6 E(): 1.7e-103
Smith-Waterman score: 3106; 84.932% identity (85.103% similar) in 584 aa overlap (41-537:1-584)
20 30 40 50 60 70
mKIAA0 QGDQPGLQRTSQTGYVTSRGGAEVPCGLETMYKRNGLMASVLVTSATPQGSSSSDSLEGQ
::::::::::::::::::::::::::::::
gi|123 MYKRNGLMASVLVTSATPQGSSSSDSLEGQ
10 20 30
80 90 100 110
mKIAA0 SCDYASKSYDAVVFDVLKVTPEEFA-----------------ELASCGWSKKEKHSLAPN
::::::::::::::::::::::::: ::::::::::::::::::
gi|123 SCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPN
40 50 60 70 80 90
120 130 140 150 160 170
mKIAA0 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 VVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQS
100 110 120 130 140 150
180 190 200 210 220 230
mKIAA0 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 APIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDL
160 170 180 190 200 210
240 250 260 270 280 290
mKIAA0 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 IYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEE
220 230 240 250 260 270
300 310 320 330 340 350
mKIAA0 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 LQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLP
280 290 300 310 320 330
360
mKIAA0 TPPVPRHRKSHSLGN---------------------------------------------
:::::::::::::::
gi|123 TPPVPRHRKSHSLGNNLMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLTHTSST
340 350 360 370 380 390
370 380 390 400
mKIAA0 -------------------------KGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTC
.::::::::::::::::::::::::::::::::::
gi|123 AITNGLSLGSSESSEFSEEMSAGLERGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTC
400 410 420 430 440 450
410 420 430 440 450 460
mKIAA0 TVGSSATVPTMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 TVGSSATVPTMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHY
460 470 480 490 500 510
470 480 490 500 510 520
mKIAA0 KSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|123 KSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACK
520 530 540 550 560 570
530
mKIAA0 SSRPQVPANLMSFE
::::::::::::::
gi|123 SSRPQVPANLMSFE
580
537 residues in 1 query sequences
2727779818 residues in 7921681 library sequences
Tcomplib [34.26] (2 proc)
start: Sat Mar 14 05:51:22 2009 done: Sat Mar 14 05:58:33 2009
Total Scan time: 963.660 Total Display time: 0.160
Function used was FASTA [version 34.26.5 April 26, 2007]