FASTA searches a protein or DNA sequence data bank version 3.4t11 Apr 17, 2002 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 ../query/mKIAA4255.ptfa, 1460 aa vs ./tmplib.26680 library 1767557 residues in 2168 sequences Expectation_n fit: rho(ln(x))= 8.8052+/-0.00554; mu= 0.0111+/- 0.365 mean_var=244.4384+/-60.193, 0's: 0 Z-trim: 4 B-trim: 110 in 1/35 Lambda= 0.0820 FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 40, opt: 28, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2168) mKIAA1123 ( 1389 res) mbg04765 (1389) 2238 279 4.2e-75 mKIAA1169 ( 590 res) mph00252 ( 590) 217 40 0.0023 >>mKIAA1123 ( 1389 res) mbg04765 (1389 aa) initn: 2948 init1: 1846 opt: 2238 Z-score: 1440.7 bits: 279.1 E(): 4.2e-75 Smith-Waterman score: 4389; 55.445% identity (61.194% ungapped) in 1405 aa overlap (49-1355:1-1371) 20 30 40 50 60 70 mKIAA4 LLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL .:::::::::::::::::::::::::: :: mKIAA1 LPDRKNFDSLLWAIVTVFQILTQEDWNKVL 10 20 30 80 90 100 110 120 mKIAA4 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSDTDE--------- :::::::::::::::.::::::::::::::::::::::::: . : ::. mKIAA1 YNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDTSGQLSCIQLPV 40 50 60 70 80 90 130 140 150 160 170 180 mKIAA4 -----DKTSTHLEEDF-DKLRDVRATEMKMYSLAVTPNGHLEGRGSLPPPLITHTAATPM : :... : :: . : . . : .: :. . : : : :: :::: ::::::: mKIAA1 NSQGGDATKSESEPDFFSPSVDGDGDRKKRLAL-VALGEHSELRKSLLPPLIIHTAATPM 100 110 120 130 140 190 200 210 220 230 mKIAA4 PTPKSSPHLDMAHTLLD-SRR-SSSGSVDPQLG--DQKSLASLRSSPCAPWGPNSAGSSR :::: ....: . ::: :::::..: . ..:: : :::: .::. :. .:: mKIAA1 SLPKSSS-TGVGEALGSGSRRTSSSGSAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSR 150 160 170 180 190 200 240 250 260 270 280 290 mKIAA4 RSSWNSLGRAPSLKRRSQCGERESLLSGEGKGSTDDEAEDSRPNSGTHPGASPGPRATPL ::: ::::::::::::: :::.:::::::. : :.: :.:. . .. :.. :.. mKIAA1 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE-ESSEEDRASPAGSDHRHRGSLE 210 220 230 240 250 260 300 310 320 330 340 350 mKIAA4 RRAES-LGHRSTMDLCP--PRPAT--LLPTKFRDCNGQMVALPSEFFLRIDSHKEDAAEF :.:.: . .:... : : :. .. .::::. .. :: :. :. . mKIAA1 REAKSSFDLPDTLQV-PGLHRTASGRSSASEHQDCNGKSASGRLARTLRADDPPLDGDDG 270 280 290 300 310 320 360 370 380 390 400 410 mKIAA4 DDDIEDSCCFRLHKVLEPYAPQWCSSRESWALYLFPPQNRLRVSCQKVIAHKMFDHVVLV ::. . : ::. .. : : :.::. :.::::.:.:. :...:.:::::::::: mKIAA1 DDEGNLSKGERLRAWVRARLPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLV 330 340 350 360 370 380 420 430 440 450 460 470 mKIAA4 FIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLWGEHAYLQS .:::::::::.::: ::: :.:: ::..:::::::.:..:: ::::::: .::.:::.: mKIAA1 IIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRS 390 400 410 420 430 440 480 490 500 510 520 530 mKIAA4 SWNVLDGLLVLVSLVDIIVAVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVET :::::::::::.:..::.:...: .:.::::.::::::::::::::::::: :::::::: mKIAA1 SWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVET 450 460 470 480 490 500 540 550 560 570 580 590 mKIAA4 LISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGTDTRNITTKAECHAAHYRWVR :.:::.::::::.:::::::::::::::::::::. :.: ::::::.:..: : ::::: mKIAA1 LMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVR 510 520 530 540 550 560 600 610 620 630 640 650 mKIAA4 RKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIV .:::::::::::::::::.::::::.::::::::::.::::..::::::::::::::::: mKIAA1 HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 570 580 590 600 610 620 660 670 680 690 mKIAA4 SFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR---------------- .::::::::::::::::::::::: :::::::::::.:::..:: mKIAA1 AFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRNLMLDDVIASGSSASA 630 640 650 660 670 680 700 710 720 730 740 750 mKIAA4 --KAQRRPYYADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALK .:: .:::.:::. : .: :::::::::::: .: :::.::.::::.::. :::::: mKIAA1 ASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALK 690 700 710 720 730 740 760 770 780 790 800 810 mKIAA4 YCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPIN :::.::..::.:...:::::::::::.::::::::::::::::::.:::::.::.:::: mKIAA1 ICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPIN 750 760 770 780 790 800 820 830 840 850 860 870 mKIAA4 PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVEL ::::::::::::::::::::::.:::::::::.:::::::::::::::::::.::::::: mKIAA1 PTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVEL 810 820 830 840 850 860 880 890 900 910 920 930 mKIAA4 FGRLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLS :: :::.: .:::::.::::: :::::::::::::::::::::::::::.: .:. : mKIAA1 FGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQEST-C-- 870 880 890 900 910 920 940 950 960 970 980 990 mKIAA4 YLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEMDAEIELEI------ : ..::.:::.:::.:::::::::.::::::::::::::.:.::..::.:::. mKIAA1 YNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQ 930 940 950 960 970 980 1000 1010 mKIAA4 --------------------------AQGSTAQ------------PPSTAQESQGTDPDT : .::. : . . .: : mKIAA1 PHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLG 990 1000 1010 1020 1030 1040 1020 1030 1040 1050 1060 1070 mKIAA4 PNLLVVRKVSVSRMLSLPNDSYMFRPVAPAAAPHSHPLQEVEMETYTGPVTSAHSPSLEP :.::.::: .::: :::::::: : . : .: . .. .: . :.:: . mKIAA1 PDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLP-KAQSGSILSVHSQPADT 1050 1060 1070 1080 1090 1100 1080 1090 1100 1110 1120 mKIAA4 RTSFQVPSAAS---SPARASDPLCALSPRDTP--RSLSLSRILYRQEAMHAESLEGQIDD .:.:. : .: : : . :. : :: .: : :: :....::. : mKIAA1 SCILQLPKDAHYLLQPHGA--PTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLG 1110 1120 1130 1140 1150 1160 1130 1140 1150 1160 1170 1180 mKIAA4 AGEDGIPDYTEPAENISMSQAPLGTLRSPPCSPRPAS-VRTRKHTFGQHCISSRPPTLGG . :: . . . :. .. :.. : : . : .: .. :: : : : mKIAA1 SREDLLSEVSGPSCPLTRSSSFWGG-SSIQVQQRSGSQSKVSKH------IRLPAPCPGL 1170 1180 1190 1200 1210 1190 1200 1210 1220 1230 1240 mKIAA4 DDAEAADPADEEVSHITSSAHPWPATE--PHSPEASPTASPAKGTVGSGRDPHRFCSVDA . . : :: . . : .. : . . : : : : :: :: .. ::.: mKIAA1 EPSWAKDPQETRSSLELDTELSWISGDLLPSSQEE-PL-SP--------RDLKKCYSVEA 1220 1230 1240 1250 1260 1250 1260 1270 1280 1290 1300 mKIAA4 QSFLDKPGRP-DAQRWSSVE---LDNGDGHLESGEVRARASELEPALGARRKKKMSPPCI :: .:: : :: :. ::.:. . ... . :.: :::.::: : mKIAA1 QSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSI 1270 1280 1290 1300 1310 1320 1310 1320 1330 1340 1350 1360 mKIAA4 SIDPPTEDEGSSRPPAAEGGNTTLRRRTPSCEAALHRDCPESTEGPGTGGDPVAKGERWG ::::: :..: ::: . : . ::::.:. .. .: :. .:...: : mKIAA1 SIDPP-ESQGP-RPPCSPG--VCLRRRAPASDS---KDPSASSPLDSTAASPSPKKDALS 1330 1340 1350 1360 1370 1370 1380 1390 1400 1410 1420 mKIAA4 QASCRAEHLTVPNFAFEPLDMGGPGGDCFLDSDQSVTPEPRVSSLGAIVPLILETELSMP mKIAA1 LSGLSSDPTDLDP 1380 >>mKIAA1169 ( 590 res) mph00252 (590 aa) initn: 361 init1: 143 opt: 217 Z-score: 152.9 bits: 39.6 E(): 0.0023 Smith-Waterman score: 329; 22.034% identity (29.613% ungapped) in 590 aa overlap (538-1036:2-531) 510 520 530 540 550 560 mKIAA4 RVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGK :: :. .:.:. :.:::.::: ::. mKIAA1 QSLPPFMDILLLLLFFMIIFAILGFYLFS-- 10 20 570 580 590 600 610 620 mKIAA4 FYYCEGTDTRNITTKAECHAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD . .: :..: .....:::: . .. ..:. mKIAA1 ---TNPSDPY---------------------FSTLENSIVNLFVLLTTANFPDVMM---- 30 40 50 60 630 640 650 660 670 mKIAA4 AVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-----HKCR-------- : ..::: ..:: .: : .:..:....:: ..: :: . mKIAA1 -------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFKSLLLHKRT 70 80 90 100 110 680 690 mKIAA4 --QH---------QEAEEARRREEKRLR----RLERRRR--------------------- :: . : . :. : .: :. :.: mKIAA1 AIQHAYGLLASQRRPAGISYRQFEGLMRFYKPRMSARERFLTFKALNQSNTPLLSLKDFY 120 130 140 150 160 170 700 710 720 730 740 mKIAA4 ------------KAQRRPYYADYSHTR----RSIHSLCTSHYLDLFITFIICLNVITMSM : .:. .. . .: ..:. : .:. .. :. ... .: . . . mKIAA1 DIYEVAALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVNGVWILV 180 190 200 210 220 230 750 760 770 780 790 800 mKIAA4 EHY--NQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIM : . . . .. . . :: .. : .:....: ..... :: .:.... .... mKIAA1 ETFMLKGGNFTSKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFL 240 250 260 270 280 290 810 820 830 840 850 860 mKIAA4 GIALEEIEMNAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL :. :: .: . .. ::: ..:.:.:. .: .:::. . ::....::: mKIAA1 GLL--------ALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGL 300 310 320 330 340 870 880 890 mKIAA4 LFMLLFFIYAALGVELF-GRL--ECSEDNPC------------------EGLSRHATFTN .. ... .: .:.:.: ::: .: . . :: .: : mKIAA1 TLLTFYYSFAIVGMEFFNGRLTPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDN 350 360 370 380 390 400 900 910 920 930 940 950 mKIAA4 FGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLPALSPVYFVTFVLVAQFVLVN . .:.:::.... .:: ::. . : . .: : .::.:: .:.. :.. mKIAA1 ILNSFVTLFELTVVNNWYIIMEGV----TSQTSH-------WSRLYFMTFYIVTMVVMTI 410 420 430 440 450 960 970 980 990 1000 1010 mKIAA4 VVVAVLMKHLEESN-KEAREDAEMDAE--IELEIAQGSTAQPPSTAQESQGTDPDTPNLL .:. .: . . : .. .:.:.:. :: :... .: .::. :. :: mKIAA1 IVAFILEAFVFRMNYSRKSQDSEVDSGIVIEKEMSKEELMAVLELYREERGTSSDVTRLL 460 470 480 490 500 510 1020 1030 1040 1050 1060 1070 mKIAA4 VVRKVSVSRMLSLPNDSYMFRPVAPAAAPHSHPLQEVEMETYTGPVTSAHSPSLEPRTSF ..:.: . ..:..: mKIAA1 D----TLSQMEKYQQNSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQKLRGSV 520 530 540 550 560 570 1460 residues in 1 query sequences 1767557 residues in 2168 library sequences Scomplib [34t11] start: Mon Mar 27 11:06:36 2006 done: Mon Mar 27 11:06:37 2006 Scan time: 1.270 Display time: 0.250 Function used was FASTA [version 3.4t11 Apr 17, 2002]