# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mbg00857.fasta.nr -Q ../query/mKIAA1132.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 mKIAA1132, 1723 aa vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library 2727779818 residues in 7921681 sequences statistics sampled from 60000 to 7896683 sequences Expectation_n fit: rho(ln(x))= 6.3894+/-0.000207; mu= 11.0846+/- 0.011 mean_var=148.8641+/-28.202, 0's: 40 Z-trim: 116 B-trim: 0 in 0/65 Lambda= 0.105119 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 41, opt: 29, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7921681) gi|194212724|ref|XP_001917571.1| PREDICTED: simila (1906) 10598 1620.7 0 gi|124486901|ref|NP_001074739.1| Down syndrome cel (2111) 10317 1578.1 0 gi|149041531|gb|EDL95372.1| Down syndrome cell adh (2111) 10295 1574.8 0 gi|114640548|ref|XP_508782.2| PREDICTED: Down synd (1842) 10226 1564.3 0 gi|114640546|ref|XP_001158737.1| PREDICTED: Down s (2113) 10226 1564.3 0 gi|119587726|gb|EAW67322.1| Down syndrome cell adh (1843) 10210 1561.9 0 gi|18033452|gb|AAL57166.1|AF334384_1 Down syndrome (2053) 10210 1561.9 0 gi|73620825|sp|Q8TD84.2|DSCL1_HUMAN RecName: Full= (2053) 10210 1561.9 0 gi|20067221|gb|AAM09558.1|AF491813_1 Down syndrome (2113) 10210 1561.9 0 gi|23450945|gb|AAN32614.1|AF304305_1 Down syndrome (1842) 10199 1560.2 0 gi|23450943|gb|AAN32613.1|AF304304_1 Down syndrome (2053) 10199 1560.2 0 gi|73955092|ref|XP_546506.2| PREDICTED: similar to (2048) 10189 1558.7 0 gi|66792568|gb|AAH96527.1| Dscaml1 protein [Mus mu (1389) 9253 1416.6 0 gi|189528761|ref|XP_001920060.1| PREDICTED: simila (1909) 8895 1362.4 0 gi|118083919|ref|XP_416734.2| PREDICTED: similar t (2310) 6794 1043.9 0 gi|119630025|gb|EAX09620.1| Down syndrome cell adh (1776) 6772 1040.4 0 gi|12643619|sp|O60469.2|DSCAM_HUMAN RecName: Full= (2012) 6772 1040.5 0 gi|168277474|dbj|BAG10715.1| down syndrome cell ad (2012) 6772 1040.5 0 gi|62087852|dbj|BAD92373.1| Down syndrome cell adh (2023) 6772 1040.5 0 gi|194226263|ref|XP_001491675.2| PREDICTED: simila (2058) 6769 1040.1 0 gi|126325281|ref|XP_001370653.1| PREDICTED: simila (2020) 6755 1037.9 0 gi|11066998|gb|AAG28796.1|AF315558_1 Down syndrome (2013) 6748 1036.9 0 gi|18033454|gb|AAL57167.1|AF334385_1 Down syndrome (2013) 6747 1036.7 0 gi|119630026|gb|EAX09621.1| Down syndrome cell adh (1732) 6745 1036.3 0 gi|18032392|gb|AAL56711.1|AF289030_1 Down syndrome (1746) 6745 1036.3 0 gi|114684213|ref|XP_001171505.1| PREDICTED: Down s (1994) 6745 1036.4 0 gi|74001457|ref|XP_544893.2| PREDICTED: similar to (1993) 6736 1035.0 0 gi|7512400|pir||T08851 Down syndrome cell adhesion (1896) 6732 1034.4 0 gi|114684209|ref|XP_001171521.1| PREDICTED: Down s (2016) 6280 965.9 0 gi|211853089|gb|AAI68033.1| Unknown (protein for M (2008) 6086 936.5 0 gi|15778228|gb|AAL07355.1|AF351196_1 Down syndrome ( 875) 5826 896.6 0 gi|3169768|gb|AAC17967.1| Down syndrome cell adhes (1571) 5526 851.4 0 gi|47606666|gb|AAT36313.1| Down syndrome cell adhe (2024) 5014 773.9 0 gi|189519138|ref|XP_693739.3| PREDICTED: novel pro (1886) 4947 763.7 0 gi|74193267|dbj|BAE20628.1| unnamed protein produc ( 727) 4822 744.3 8.7e-212 gi|149060245|gb|EDM10959.1| rCG52779 [Rattus norve (1234) 4805 742.0 7.4e-211 gi|119923336|ref|XP_592662.3| PREDICTED: similar t (1226) 4776 737.6 1.6e-209 gi|47225054|emb|CAF97469.1| unnamed protein produc (1944) 4141 641.5 2.1e-180 gi|7717375|emb|CAB90444.1| human CHD2-52 down synd (1029) 3836 594.9 1.1e-166 gi|224042523|ref|XP_002190452.1| PREDICTED: Down s (1032) 3823 593.0 4.5e-166 gi|148693706|gb|EDL25653.1| mCG141917 [Mus musculu (1136) 3751 582.1 9.2e-163 gi|122891302|emb|CAM14296.1| novel protein similar (1904) 3623 562.9 9.1e-157 gi|126326972|ref|XP_001380842.1| PREDICTED: simila ( 482) 2927 456.7 2.1e-125 gi|19852060|gb|AAL99985.1|AF487347_1 Down syndrome ( 915) 2774 433.8 3.2e-118 gi|113194600|gb|ABI31046.1| down syndrome cell adh (2031) 2638 413.6 8.8e-112 gi|113194598|gb|ABI31044.1| down syndrome cell adh (2013) 2629 412.2 2.3e-111 gi|19852064|gb|AAL99987.1|AF487349_1 Down syndrome ( 381) 2514 394.0 1.3e-106 gi|156553222|ref|XP_001599258.1| PREDICTED: simila (1963) 2515 394.9 3.5e-106 gi|212518347|gb|EEB20100.1| down syndrome cell adh (2018) 2501 392.8 1.6e-105 gi|51103281|gb|AAT96374.1| Dscam [Apis mellifera] (1946) 2482 389.9 1.1e-104 >>gi|194212724|ref|XP_001917571.1| PREDICTED: similar to (1906 aa) initn: 10642 init1: 6010 opt: 10598 Z-score: 8687.5 bits: 1620.7 E(): 0 Smith-Waterman score: 10734; 91.924% identity (93.158% similar) in 1783 aa overlap (1-1723:177-1906) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN ::::::::::::::::: :: ::::::::: gi|194 YICEVTNTFGSAEATGTLTVIDPLHVTLTPKKLKTGIGSTVILSCALMGSTEFTIRWYRN 150 160 170 180 190 200 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.::::::::::::::::::::::::::::::::::::: gi|194 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV 210 220 230 240 250 260 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::..:::::::::::::::::::::: gi|194 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPILRDGSHRTNQYTMSDGTTISHMN 270 280 290 300 310 320 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::::::::: ::::::::::::::::::::::::::: gi|194 VTGPQIRDGGVYRCTARNSVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 330 340 350 360 370 380 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 390 400 410 420 430 440 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 450 460 470 480 490 500 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 510 520 530 540 550 560 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 570 580 590 600 610 620 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|194 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 630 640 650 660 670 680 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 DRVMRYAITTKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 690 700 710 720 730 740 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 750 760 770 780 790 800 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 810 820 830 840 850 860 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::: gi|194 KELQNGVIRGYQIGYRENSPGSNG------------------------------------ 870 880 890 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW .:::::::::::::::::::::::::::.:::::::::::::: gi|194 -----------------MPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 900 910 920 930 810 mKIAA1 SLYVDG---------------------------------------------------EWG :::::: .:: gi|194 SLYVDGVLDGSTLVSDLLGKEGPAAQASKVPPVLTQSPLKTLALPWDPLPKLFFRVFKWG 940 950 960 970 980 990 820 830 840 850 860 870 mKIAA1 EMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 EMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1000 1010 1020 1030 1040 1050 880 890 900 910 920 930 mKIAA1 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1060 1070 1080 1090 1100 1110 940 950 960 970 980 990 mKIAA1 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1120 1130 1140 1150 1160 1170 1000 1010 1020 1030 1040 1050 mKIAA1 VKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|194 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1180 1190 1200 1210 1220 1230 1060 1070 1080 1090 1100 1110 mKIAA1 QVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 QVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSF 1240 1250 1260 1270 1280 1290 1120 1130 1140 1150 1160 1170 mKIAA1 KLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 KLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNL 1300 1310 1320 1330 1340 1350 1180 1190 1200 1210 1220 1230 mKIAA1 QGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRMRACNSAGCG :::::::::::::::::::::::::::.::::: :::::::::::::::::::::::::: gi|194 QGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1360 1370 1380 1390 1400 1410 1240 1250 1260 1270 1280 1290 mKIAA1 NETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFVVRKKRKEKR ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|194 NETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVRKKRKEKR 1420 1430 1440 1450 1460 1470 1300 1310 1320 1330 1340 1350 mKIAA1 LKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEGIKQLGDDKA ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: gi|194 LKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKA 1480 1490 1500 1510 1520 1530 1360 1370 1380 1390 1400 1410 mKIAA1 TIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSRKNVKSAHST ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|194 TIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSSGPLIDMSDIRPGTNPVSRKNVKSAHST 1540 1550 1560 1570 1580 1590 1420 1430 1440 1450 1460 1470 mKIAA1 RNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 RNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVS 1600 1610 1620 1630 1640 1650 1480 1490 1500 1510 1520 1530 mKIAA1 TESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 TESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMST 1660 1670 1680 1690 1700 1710 1540 1550 1560 1570 1580 1590 mKIAA1 PSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFFRKADGREPW ::::::::::.:::::::::::::::::::::::::::::::::.:::::::::::::: gi|194 PSEPGICRFTSSPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPC 1720 1730 1740 1750 1760 1770 1600 1610 1620 1630 1640 1650 mKIAA1 PVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQRTLAMPAPP :::::::::.:::.:.:::::::::::::::::::::::: ::..::::::::::::::: gi|194 PVVPPREASIRNLARTYHTQARHLTLDPASKPLGLPHPGAPAAASTATLPQRTLAMPAPP 1780 1790 1800 1810 1820 1830 1660 1670 1680 1690 1700 1710 mKIAA1 AGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTPGVGRSQK ::::::::::::.:: :::::::::::::::::::::::::::::::::::: ::::::: gi|194 AGTAPPAPGPTPAEPPAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQK 1840 1850 1860 1870 1880 1890 1720 mKIAA1 QGAGAYSKSYTLV ::::::::::::: gi|194 QGAGAYSKSYTLV 1900 >>gi|124486901|ref|NP_001074739.1| Down syndrome cell ad (2111 aa) initn: 11446 init1: 10317 opt: 10317 Z-score: 8456.7 bits: 1578.1 E(): 0 Smith-Waterman score: 11432; 99.307% identity (99.423% similar) in 1732 aa overlap (1-1723:380-2111) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|124 YICEVTNTFGSAEANGILTVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 350 360 370 380 390 400 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV 410 420 430 440 450 460 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN 470 480 490 500 510 520 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::::::::: ::::::::::::::::::::::::::: gi|124 VTGPQIRDGGVYRCTARNSVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 530 540 550 560 570 580 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 590 600 610 620 630 640 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 650 660 670 680 690 700 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 710 720 730 740 750 760 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 770 780 790 800 810 820 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP 830 840 850 860 870 880 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 890 900 910 920 930 940 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 950 960 970 980 990 1000 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 1010 1020 1030 1040 1050 1060 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1070 1080 1090 1100 1110 1120 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|124 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1130 1140 1150 1160 1170 1180 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1190 1200 1210 1220 1230 1240 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1250 1260 1270 1280 1290 1300 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1310 1320 1330 1340 1350 1360 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1370 1380 1390 1400 1410 1420 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1430 1440 1450 1460 1470 1480 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1490 1500 1510 1520 1530 1540 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM 1550 1560 1570 1580 1590 1600 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV 1610 1620 1630 1640 1650 1660 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|124 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1670 1680 1690 1700 1710 1720 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR 1730 1740 1750 1760 1770 1780 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1790 1800 1810 1820 1830 1840 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1850 1860 1870 1880 1890 1900 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF 1910 1920 1930 1940 1950 1960 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 RKADGREPCPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ 1970 1980 1990 2000 2010 2020 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|124 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 2030 2040 2050 2060 2070 2080 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV :::::::::::::::::::::: gi|124 TPGVGRSQKQGAGAYSKSYTLV 2090 2100 2110 >>gi|149041531|gb|EDL95372.1| Down syndrome cell adhesio (2111 aa) initn: 11424 init1: 10295 opt: 10295 Z-score: 8438.7 bits: 1574.8 E(): 0 Smith-Waterman score: 11410; 99.076% identity (99.307% similar) in 1732 aa overlap (1-1723:380-2111) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|149 YICEVTNTFGSAEANGVLTVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 350 360 370 380 390 400 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV 410 420 430 440 450 460 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN 470 480 490 500 510 520 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::::::::: ::::::::::::::::::::::::::: gi|149 VTGPQIRDGGVYRCTARNSVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 530 540 550 560 570 580 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 590 600 610 620 630 640 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 650 660 670 680 690 700 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 710 720 730 740 750 760 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 770 780 790 800 810 820 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: gi|149 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 830 840 850 860 870 880 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 890 900 910 920 930 940 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 950 960 970 980 990 1000 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 1010 1020 1030 1040 1050 1060 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 KELQNGIIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1070 1080 1090 1100 1110 1120 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|149 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1130 1140 1150 1160 1170 1180 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1190 1200 1210 1220 1230 1240 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1250 1260 1270 1280 1290 1300 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: gi|149 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWLKDVRLPC 1310 1320 1330 1340 1350 1360 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1370 1380 1390 1400 1410 1420 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1430 1440 1450 1460 1470 1480 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1490 1500 1510 1520 1530 1540 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM 1550 1560 1570 1580 1590 1600 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV 1610 1620 1630 1640 1650 1660 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|149 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1670 1680 1690 1700 1710 1720 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR 1730 1740 1750 1760 1770 1780 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1790 1800 1810 1820 1830 1840 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1850 1860 1870 1880 1890 1900 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF 1910 1920 1930 1940 1950 1960 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 RKADGREPCPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ 1970 1980 1990 2000 2010 2020 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: gi|149 RTLAMPAPPAGTAPPAPGPTPSEPSAPPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 2030 2040 2050 2060 2070 2080 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV :::::::::::::::::::::: gi|149 TPGVGRSQKQGAGAYSKSYTLV 2090 2100 2110 >>gi|114640548|ref|XP_508782.2| PREDICTED: Down syndrome (1842 aa) initn: 11326 init1: 10226 opt: 10226 Z-score: 8382.8 bits: 1564.3 E(): 0 Smith-Waterman score: 11312; 97.921% identity (99.018% similar) in 1732 aa overlap (1-1723:111-1842) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::.:::::: gi|114 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFSIRWYRN 90 100 110 120 130 140 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|114 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 150 160 170 180 190 200 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|114 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 210 220 230 240 250 260 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|114 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 270 280 290 300 310 320 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 330 340 350 360 370 380 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 390 400 410 420 430 440 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 450 460 470 480 490 500 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 510 520 530 540 550 560 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|114 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 570 580 590 600 610 620 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 630 640 650 660 670 680 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 690 700 710 720 730 740 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 750 760 770 780 790 800 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 810 820 830 840 850 860 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 870 880 890 900 910 920 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|114 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 930 940 950 960 970 980 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 990 1000 1010 1020 1030 1040 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1050 1060 1070 1080 1090 1100 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|114 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1110 1120 1130 1140 1150 1160 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1170 1180 1190 1200 1210 1220 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1230 1240 1250 1260 1270 1280 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|114 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1290 1300 1310 1320 1330 1340 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|114 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1350 1360 1370 1380 1390 1400 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|114 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1410 1420 1430 1440 1450 1460 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR 1470 1480 1490 1500 1510 1520 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1530 1540 1550 1560 1570 1580 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1590 1600 1610 1620 1630 1640 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|114 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1650 1660 1670 1680 1690 1700 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.:::::::::::::::::::::::: ::..:::::: gi|114 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKPLGLPHPGAPAAASTATLPQ 1710 1720 1730 1740 1750 1760 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|114 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 1770 1780 1790 1800 1810 1820 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|114 TSGVGRSQKQGAGAYSKSYTLV 1830 1840 >>gi|114640546|ref|XP_001158737.1| PREDICTED: Down syndr (2113 aa) initn: 11326 init1: 10226 opt: 10226 Z-score: 8382.1 bits: 1564.3 E(): 0 Smith-Waterman score: 11312; 97.921% identity (99.018% similar) in 1732 aa overlap (1-1723:382-2113) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::.:::::: gi|114 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFSIRWYRN 360 370 380 390 400 410 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|114 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 420 430 440 450 460 470 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|114 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 480 490 500 510 520 530 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|114 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 540 550 560 570 580 590 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 600 610 620 630 640 650 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 660 670 680 690 700 710 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 720 730 740 750 760 770 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 780 790 800 810 820 830 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|114 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 840 850 860 870 880 890 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 900 910 920 930 940 950 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 960 970 980 990 1000 1010 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 1020 1030 1040 1050 1060 1070 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1080 1090 1100 1110 1120 1130 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|114 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1140 1150 1160 1170 1180 1190 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|114 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1200 1210 1220 1230 1240 1250 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1260 1270 1280 1290 1300 1310 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1320 1330 1340 1350 1360 1370 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|114 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1380 1390 1400 1410 1420 1430 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1440 1450 1460 1470 1480 1490 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1500 1510 1520 1530 1540 1550 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|114 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1560 1570 1580 1590 1600 1610 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|114 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1620 1630 1640 1650 1660 1670 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|114 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1680 1690 1700 1710 1720 1730 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR 1740 1750 1760 1770 1780 1790 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1800 1810 1820 1830 1840 1850 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1860 1870 1880 1890 1900 1910 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|114 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1920 1930 1940 1950 1960 1970 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.:::::::::::::::::::::::: ::..:::::: gi|114 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKPLGLPHPGAPAAASTATLPQ 1980 1990 2000 2010 2020 2030 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|114 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 2040 2050 2060 2070 2080 2090 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|114 TSGVGRSQKQGAGAYSKSYTLV 2100 2110 >>gi|119587726|gb|EAW67322.1| Down syndrome cell adhesio (1843 aa) initn: 11313 init1: 10210 opt: 10210 Z-score: 8369.7 bits: 1561.9 E(): 0 Smith-Waterman score: 11299; 97.864% identity (98.961% similar) in 1732 aa overlap (1-1723:112-1843) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|119 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 90 100 110 120 130 140 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|119 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 150 160 170 180 190 200 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|119 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 210 220 230 240 250 260 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|119 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 270 280 290 300 310 320 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 330 340 350 360 370 380 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 390 400 410 420 430 440 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 450 460 470 480 490 500 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 510 520 530 540 550 560 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|119 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 570 580 590 600 610 620 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 630 640 650 660 670 680 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 690 700 710 720 730 740 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 750 760 770 780 790 800 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 810 820 830 840 850 860 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|119 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 870 880 890 900 910 920 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|119 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 930 940 950 960 970 980 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 990 1000 1010 1020 1030 1040 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1050 1060 1070 1080 1090 1100 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|119 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1110 1120 1130 1140 1150 1160 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1170 1180 1190 1200 1210 1220 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1230 1240 1250 1260 1270 1280 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|119 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1290 1300 1310 1320 1330 1340 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|119 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1350 1360 1370 1380 1390 1400 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|119 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1410 1420 1430 1440 1450 1460 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|119 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1470 1480 1490 1500 1510 1520 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1530 1540 1550 1560 1570 1580 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1590 1600 1610 1620 1630 1640 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|119 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1650 1660 1670 1680 1690 1700 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.::::::::::::::: :::::::: ::..:::::: gi|119 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQ 1710 1720 1730 1740 1750 1760 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|119 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 1770 1780 1790 1800 1810 1820 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|119 TSGVGRSQKQGAGAYSKSYTLV 1830 1840 >>gi|18033452|gb|AAL57166.1|AF334384_1 Down syndrome cel (2053 aa) initn: 11313 init1: 10210 opt: 10210 Z-score: 8369.1 bits: 1561.9 E(): 0 Smith-Waterman score: 11299; 97.864% identity (98.961% similar) in 1732 aa overlap (1-1723:322-2053) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|180 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 300 310 320 330 340 350 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|180 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 360 370 380 390 400 410 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|180 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 420 430 440 450 460 470 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|180 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 480 490 500 510 520 530 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 540 550 560 570 580 590 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 600 610 620 630 640 650 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 660 670 680 690 700 710 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 720 730 740 750 760 770 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|180 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 780 790 800 810 820 830 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 840 850 860 870 880 890 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 900 910 920 930 940 950 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 960 970 980 990 1000 1010 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1020 1030 1040 1050 1060 1070 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|180 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1080 1090 1100 1110 1120 1130 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|180 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1140 1150 1160 1170 1180 1190 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1200 1210 1220 1230 1240 1250 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1260 1270 1280 1290 1300 1310 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|180 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1320 1330 1340 1350 1360 1370 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1380 1390 1400 1410 1420 1430 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1440 1450 1460 1470 1480 1490 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|180 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1500 1510 1520 1530 1540 1550 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|180 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1560 1570 1580 1590 1600 1610 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|180 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1620 1630 1640 1650 1660 1670 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|180 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1680 1690 1700 1710 1720 1730 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1740 1750 1760 1770 1780 1790 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|180 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1800 1810 1820 1830 1840 1850 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|180 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1860 1870 1880 1890 1900 1910 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.::::::::::::::: :::::::: ::..:::::: gi|180 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQ 1920 1930 1940 1950 1960 1970 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|180 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 1980 1990 2000 2010 2020 2030 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|180 TSGVGRSQKQGAGAYSKSYTLV 2040 2050 >>gi|73620825|sp|Q8TD84.2|DSCL1_HUMAN RecName: Full=Down (2053 aa) initn: 11313 init1: 10210 opt: 10210 Z-score: 8369.1 bits: 1561.9 E(): 0 Smith-Waterman score: 11299; 97.864% identity (98.961% similar) in 1732 aa overlap (1-1723:322-2053) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|736 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 300 310 320 330 340 350 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|736 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 360 370 380 390 400 410 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|736 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 420 430 440 450 460 470 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|736 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 480 490 500 510 520 530 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 540 550 560 570 580 590 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 600 610 620 630 640 650 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 660 670 680 690 700 710 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 720 730 740 750 760 770 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|736 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 780 790 800 810 820 830 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 840 850 860 870 880 890 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 900 910 920 930 940 950 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 960 970 980 990 1000 1010 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1020 1030 1040 1050 1060 1070 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|736 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1080 1090 1100 1110 1120 1130 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|736 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1140 1150 1160 1170 1180 1190 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1200 1210 1220 1230 1240 1250 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1260 1270 1280 1290 1300 1310 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|736 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1320 1330 1340 1350 1360 1370 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1380 1390 1400 1410 1420 1430 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1440 1450 1460 1470 1480 1490 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|736 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1500 1510 1520 1530 1540 1550 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|736 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1560 1570 1580 1590 1600 1610 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|736 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1620 1630 1640 1650 1660 1670 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|736 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1680 1690 1700 1710 1720 1730 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1740 1750 1760 1770 1780 1790 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|736 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1800 1810 1820 1830 1840 1850 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|736 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1860 1870 1880 1890 1900 1910 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.::::::::::::::: :::::::: ::..:::::: gi|736 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQ 1920 1930 1940 1950 1960 1970 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|736 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 1980 1990 2000 2010 2020 2030 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|736 TSGVGRSQKQGAGAYSKSYTLV 2040 2050 >>gi|20067221|gb|AAM09558.1|AF491813_1 Down syndrome cel (2113 aa) initn: 11313 init1: 10210 opt: 10210 Z-score: 8369.0 bits: 1561.9 E(): 0 Smith-Waterman score: 11299; 97.864% identity (98.961% similar) in 1732 aa overlap (1-1723:382-2113) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|200 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 360 370 380 390 400 410 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|200 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 420 430 440 450 460 470 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|200 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 480 490 500 510 520 530 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|200 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 540 550 560 570 580 590 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 600 610 620 630 640 650 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 660 670 680 690 700 710 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 720 730 740 750 760 770 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 780 790 800 810 820 830 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|200 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 840 850 860 870 880 890 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 900 910 920 930 940 950 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 960 970 980 990 1000 1010 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 1020 1030 1040 1050 1060 1070 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1080 1090 1100 1110 1120 1130 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|200 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1140 1150 1160 1170 1180 1190 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|200 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 1200 1210 1220 1230 1240 1250 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 1260 1270 1280 1290 1300 1310 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1320 1330 1340 1350 1360 1370 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|200 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1380 1390 1400 1410 1420 1430 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1440 1450 1460 1470 1480 1490 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1500 1510 1520 1530 1540 1550 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|200 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1560 1570 1580 1590 1600 1610 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|200 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1620 1630 1640 1650 1660 1670 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|200 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1680 1690 1700 1710 1720 1730 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|200 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1740 1750 1760 1770 1780 1790 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1800 1810 1820 1830 1840 1850 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|200 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1860 1870 1880 1890 1900 1910 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|200 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1920 1930 1940 1950 1960 1970 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.::::::::::::::: :::::::: ::..:::::: gi|200 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQ 1980 1990 2000 2010 2020 2030 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|200 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 2040 2050 2060 2070 2080 2090 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|200 TSGVGRSQKQGAGAYSKSYTLV 2100 2110 >>gi|23450945|gb|AAN32614.1|AF304305_1 Down syndrome cel (1842 aa) initn: 11302 init1: 10199 opt: 10199 Z-score: 8360.7 bits: 1560.2 E(): 0 Smith-Waterman score: 11288; 97.806% identity (98.903% similar) in 1732 aa overlap (1-1723:111-1842) 10 20 30 mKIAA1 KKLKTGIGSTVILSCALTGSPEFTIRWYRN :::::::::::::::::::::::::::::: gi|234 YICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 90 100 110 120 130 140 40 50 60 70 80 90 mKIAA1 TELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIV :::::: :::::::::::::::.:::::::::::::::::::::::::::.::::::::: gi|234 TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 150 160 170 180 190 200 100 110 120 130 140 150 mKIAA1 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMN ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|234 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 210 220 230 240 250 260 160 170 180 190 200 mKIAA1 VTGPQIRDGGVYRCTARNSVGSAE---------PPSIRAMRNITAVAGRDTLINCRVIGY :::::::::::::::::: ::::: ::::::::::::::::::::::::::: gi|234 VTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGY 270 280 290 300 310 320 210 220 230 240 250 260 mKIAA1 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 PYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHV 330 340 350 360 370 380 270 280 290 300 310 320 mKIAA1 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM 390 400 410 420 430 440 330 340 350 360 370 380 mKIAA1 SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: gi|234 SSLQISSVSLKHNGNDTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 450 460 470 480 490 500 390 400 410 420 430 440 mKIAA1 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 510 520 530 540 550 560 450 460 470 480 490 500 mKIAA1 GVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP ::::::::.:::::::::::::::::::::::: :::::::::::::::::::::::::: gi|234 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP 570 580 590 600 610 620 510 520 530 540 550 560 mKIAA1 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 DRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 630 640 650 660 670 680 570 580 590 600 610 620 mKIAA1 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 ELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVD 690 700 710 720 730 740 630 640 650 660 670 680 mKIAA1 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPK 750 760 770 780 790 800 690 700 710 720 730 740 mKIAA1 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 KELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 810 820 830 840 850 860 750 760 770 780 790 800 mKIAA1 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRTTLNGVLKGYRVIFW :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|234 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 870 880 890 900 910 920 810 820 830 840 850 860 mKIAA1 SLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|234 SLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP 930 940 950 960 970 980 870 880 890 900 910 920 mKIAA1 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 GPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYR 990 1000 1010 1020 1030 1040 930 940 950 960 970 980 mKIAA1 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1050 1060 1070 1080 1090 1100 990 1000 1010 1020 1030 1040 mKIAA1 NSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|234 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF 1110 1120 1130 1140 1150 1160 1050 1060 1070 1080 1090 1100 mKIAA1 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 DTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDV 1170 1180 1190 1200 1210 1220 1110 1120 1130 1140 1150 1160 mKIAA1 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1230 1240 1250 1260 1270 1280 1170 1180 1190 1200 1210 1220 mKIAA1 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRM ::::::::::::::::::::::::::::::::::::.::::: ::::::::::::::::: gi|234 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRM 1290 1300 1310 1320 1330 1340 1230 1240 1250 1260 1270 1280 mKIAA1 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|234 RACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFI 1350 1360 1370 1380 1390 1400 1290 1300 1310 1320 1330 1340 mKIAA1 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|234 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1410 1420 1430 1440 1450 1460 1350 1360 1370 1380 1390 1400 mKIAA1 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|234 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1470 1480 1490 1500 1510 1520 1410 1420 1430 1440 1450 1460 mKIAA1 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDT 1530 1540 1550 1560 1570 1580 1470 1480 1490 1500 1510 1520 mKIAA1 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|234 DKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNEN 1590 1600 1610 1620 1630 1640 1530 1540 1550 1560 1570 1580 mKIAA1 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: gi|234 ADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFF 1650 1660 1670 1680 1690 1700 1590 1600 1610 1620 1630 1640 mKIAA1 RKADGREPWPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQ :::::::: :::::::::.:::.:.::::::::::::::: :::::::: ::..:::::: gi|234 RKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQ 1710 1720 1730 1740 1750 1760 1650 1660 1670 1680 1690 1700 mKIAA1 RTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS :::::::::::::::::::::.:: .:::::::::::::::::::::::::::::::::: gi|234 RTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMS 1770 1780 1790 1800 1810 1820 1710 1720 mKIAA1 TPGVGRSQKQGAGAYSKSYTLV : :::::::::::::::::::: gi|234 TSGVGRSQKQGAGAYSKSYTLV 1830 1840 1723 residues in 1 query sequences 2727779818 residues in 7921681 library sequences Tcomplib [34.26] (2 proc) start: Thu Mar 12 20:54:10 2009 done: Thu Mar 12 21:05:21 2009 Total Scan time: 1431.870 Total Display time: 1.830 Function used was FASTA [version 34.26.5 April 26, 2007]