FASTA searches a protein or DNA sequence data bank
version 3.4t11 Apr 17, 2002
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
../query/mKIAA0993.ptfa, 646 aa
vs ./tmplib.26680 library
1768371 residues in 2168 sequences
Expectation_n fit: rho(ln(x))= 6.2281+/-0.00589; mu= 9.8869+/- 0.396
mean_var=158.5796+/-37.912, 0's: 0 Z-trim: 25 B-trim: 109 in 1/35
Lambda= 0.1018
FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 38, opt: 26, open/ext: -10/-2, width: 16
The best scores are: opt bits E(2168)
mKIAA1607 ( 355 res) msk09334 ( 355) 906 145 1.2e-35
mKIAA0540 ( 1539 res) mbg09815 (1539) 483 84 1.5e-16
mKIAA1544 ( 1356 res) mbg00554 (1356) 426 75 4.6e-14
mKIAA0647 ( 1186 res) mbg01911 (1186) 245 48 4.3e-06
mKIAA1643 ( 950 res) mbh04344 ( 950) 242 48 5.1e-06
mKIAA1255 ( 176 res) mbg10338 ( 176) 223 44 1.2e-05
mKIAA1537 ( 628 res) mbg18407 ( 628) 227 45 1.8e-05
mKIAA4212 ( 600 res) mbg08227 ( 600) 222 45 2.9e-05
mKIAA1362 ( 1407 res) mia41047 (1407) 215 44 0.0001
mKIAA0305 ( 1536 res) mbg08215 (1536) 214 44 0.00012
mKIAA0321 ( 2548 res) mef00119 (2548) 210 44 0.00025
mKIAA1589 ( 775 res) mbh04724 ( 775) 192 40 0.00073
mFLJ00274 ( 1530 res) mpf00869 (1530) 195 41 0.00083
mKIAA0981 ( 2117 res) mib04069 (2117) 192 41 0.0014
mKIAA4239 ( 1059 res) mfj24184 (1059) 177 38 0.0041
mKIAA1435 ( 411 res) mbp03169 ( 411) 171 37 0.0041
mFLJ00238 ( 1452 res) mfj01101 (1452) 178 39 0.0045
>>mKIAA1607 ( 355 res) msk09334 (355 aa)
initn: 1032 init1: 874 opt: 906 Z-score: 732.6 bits: 144.9 E(): 1.2e-35
Smith-Waterman score: 941; 46.316% identity (49.624% ungapped) in 285 aa overlap (113-380:11-293)
90 100 110 120 130
mKIAA0 QIPKQLFKKPHPPKRVRSRLNGDNIGISVPPGATSDKIFFHHLDNLRPSLTPVKEL----
:: ... :.: : :::: . ::..
mKIAA1 GKDASTPVGLPGHSQS--FLHSLPALRPSQVTVKDMYLFS
10 20 30
140 150 160 170 180 190
mKIAA0 ------KEPVGQIVCTDKGILAVEQNKVLIPPAWNKTFAWGYADLSCRLGTYESDKAVTV
: .:.:: :.:.:::::.::.:.:: ::.::.::. :.:: ::.: ::: . .
mKIAA1 LGSESPKGAIGHIVPTEKSILAVEKNKLLMPPLWNRTFSWGFDDFSCCLGSYGSDKILMT
40 50 60 70 80 90
200 210 220 230 240 250
mKIAA0 YECLSEWGQILCAVCPNPKLVITGGTSTVVCVWEMGTSKEKAKPLTLKQALLGHTDTVTC
.: :. :: ::::::.: ...:.:.:.:::.::.. : . . : :.::: :::..:::
mKIAA1 FENLAAWGPCLCAVCPSPTMIVTSGASAVVCIWELSLVKGRPRGLKLRQALYGHTQAVTC
100 110 120 130 140 150
260 270 280 290 300 310
mKIAA0 ATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYI
:::... ..::::.:::::.:::..:: .. : :: .::. :....: ::::::...
mKIAA1 LTASVTFSLLVSGSQDRTCILWDLDHLSRVACLPVHREGISAIAISDVSGTIVSCAGAHL
160 170 180 190 200 210
320 330 340 350 360 370
mKIAA0 HVWSINGNPIVSVNTFTGRSQQIVCCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVP
.:..::.:..:..: : :.:::. : ::...::.:: .::.::.:. : ...:
mKIAA1 SLWNVNGQPLASITTAWGPEGTITCCCIVEGPAWDASHVIITGSKDGMVRIWKTEDVKMP
220 230 240 250 260 270
380 390 400 410 420
mKIAA0 -------ETPAPEPVEDLEMQEGCPEAQIGQQAQDDDSSDSETEEPSVSQDPKDTSSQPS
: :. ::.
mKIAA1 VPRQAVMEEPSTEPLSPRGHKWAKNLALSRELDVSVALSGKPSKASPAVTALAITRNQSK
280 290 300 310 320 330
>>mKIAA0540 ( 1539 res) mbg09815 (1539 aa)
initn: 509 init1: 383 opt: 483 Z-score: 389.4 bits: 83.6 E(): 1.5e-16
Smith-Waterman score: 523; 33.240% identity (37.658% ungapped) in 358 aa overlap (1-336:1036-1373)
10 20 30
mKIAA0 PWAKGDPREFIRVHREALECDYVSAHLHEW
::: :.:..::. ::.::: .:::.:::::
mKIAA0 YFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWA-GSPEDFIQKHRQALESEYVSTHLHEW
1010 1020 1030 1040 1050 1060
40 50 60 70 80 90
mKIAA0 IDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFK
:::::::::.:::: ::.:::.. ::: ::. .. : .. : :.:.:::: : ::.:
mKIAA0 IDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVADERERKALEGIISNFGQTPCQLLK
1070 1080 1090 1100 1110 1120
100 110 120 130 140 150
mKIAA0 KPHPPKRVRSRLNGDNIGISVPPGATSDKIFFHHLDNLRPSLTPVKELKEPVGQIVCTDK
.:::: ::.... . . :.. .:..:..:. .. : :. . .
mKIAA0 EPHPP-----RLSAEEAANRLARLDTNSPSIFQNLNQLKAFFAEVVSEAVPLVLALVPHR
1130 1140 1150 1160 1170
160 170 180 190
mKIAA0 ---GILAVEQNKVLIPPAWNK---TFAWGYADLSCR-LGTYESDKAV---TVYECLS-EW
.... .. .:. . . : .: : . :. .: .. : . :: :
mKIAA0 QSHSFITQSSSDMLVTVSASGLLGTHTWLPYDRNINNYFTFSKDPTMGSPKVQKLLSGPW
1180 1190 1200 1210 1220 1230
200 210 220 230 240 250
mKIAA0 -------GQILCAVCPNPKLVITGGTSTVVCVWEMGTSKEKAKPL-TLKQALLGHTDTVT
.: : :: :. ::...:: :. :. . . : : . : : : ::
mKIAA0 VSDSGVSAQAL-AVAPDGKLLFSGGH------WD-GSLRVTSLPRGRLLNQLSRHLDIVT
1240 1250 1260 1270 1280 1290
260 270 280 290 300
mKIAA0 CATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDI--VSCAG
: . . ..::::: ::..: : : : : .. .. : : . :::..
mKIAA0 CLALDTCGIYLISGSRDTTCMVWRL------LQQSGLSAGLAPKPVQVLYGHVAAVSCVA
1300 1310 1320 1330 1340
310 320 330 340 350 360
mKIAA0 TYIHV-WSINGNPIVSVNTFTGRSQQIVCCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEF
.. ...:. .: : : :.:
mKIAA0 ISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPPGATLPGPISHLALGAEGQIVVQSSAC
1350 1360 1370 1380 1390 1400
>>mKIAA1544 ( 1356 res) mbg00554 (1356 aa)
initn: 492 init1: 376 opt: 426 Z-score: 344.8 bits: 75.1 E(): 4.6e-14
Smith-Waterman score: 467; 34.364% identity (37.594% ungapped) in 291 aa overlap (1-274:879-1161)
10 20 30
mKIAA0 PWAKGDPREFIRVHREALECDYVSAHLHEW
:::: :..:.:..: ::: ..:: .::.:
mKIAA1 YYLPEMFVNSNGYHLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLHQW
850 860 870 880 890 900
40 50 60 70 80 90
mKIAA0 IDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFK
:::::::::.:: ::.:.::::.: :::.:.. .:.::. . : . :.:::: :.::.
mKIAA1 IDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLI
910 920 930 940 950 960
100 110 120 130 140
mKIAA0 KPHPPKRVRSRLNGDNIGISVPPGATSDKIFFHHLDNLR-PSLTPVKELKEPVGQIVCTD
.::::. .: . : .:.. . :. :: .:: .. . . :
mKIAA1 EPHPPRSSAMHLCF----LPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHL-TI
970 980 990 1000 1010 1020
150 160 170 180 190 200
mKIAA0 KGILAVEQNKVLIPPAWNKTF----AWGYA-DLSCRLGTYESDKAVTVYECLSEWGQILC
....: .... :..: : ::. : . .: : : .. ... ::
mKIAA1 PAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHL-PIEMDPLIANNSGVNKR-QITD
1030 1040 1050 1060 1070 1080
210 220 230 240 250
mKIAA0 AVCPNPKL-----VITGGTSTV-VC-VWEMGTSKEKAKPLTLKQALLGHTDTVTCATASL
: . .. :.:. . . .: :. . ... : : ..:: :.::: . :
mKIAA1 LVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSE
1090 1100 1110 1120 1130 1140
260 270 280 290 300 310
mKIAA0 AY----HIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIH
.: ::::::: : ..:
mKIAA1 SYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCA
1150 1160 1170 1180 1190 1200
>>mKIAA0647 ( 1186 res) mbg01911 (1186 aa)
initn: 296 init1: 227 opt: 245 Z-score: 201.7 bits: 48.4 E(): 4.3e-06
Smith-Waterman score: 257; 29.070% identity (33.784% ungapped) in 172 aa overlap (487-640:1006-1171)
460 470 480 490 500 510
mKIAA0 QLSLDEKDGFIFVNYSEGQTRAHLQGPLAHPHPNPIEARSYSRLKPGYRWERQLVFRSKL
: :. . . ... ::: : . . :.
mKIAA0 SHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYRQEVEQLRRQVR
980 990 1000 1010 1020 1030
520 530 540 550
mKIAA0 TMHTAFD-RKDNTHPAE--------VTALGVS---------KDHSRILVGDSRGRVFSWS
.. .: :. . ::: : : : .:::. .... ::
mKIAA0 ELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEA-----SWE
1040 1050 1060 1070 1080 1090
560 570 580 590 600 610
mKIAA0 VSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLK
:. .. . .:: :. .. : .:. .: :..:::::::::..:: : ... : .
mKIAA0 PVDKK-ETEVTRWVPDHMASHCFNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQ
1100 1110 1120 1130 1140
620 630 640
mKIAA0 ISSPVRVCQNCYYSLQHERGAEDGPRNC
. .:: ::..:: .: :. :
mKIAA0 LYDPVLVCNSCYEHIQVSRARELMSQHLKKPIATASS
1150 1160 1170 1180
>>mKIAA1643 ( 950 res) mbh04344 (950 aa)
initn: 265 init1: 238 opt: 242 Z-score: 200.4 bits: 47.9 E(): 5.1e-06
Smith-Waterman score: 242; 22.053% identity (22.835% ungapped) in 263 aa overlap (373-630:678-936)
350 360 370 380 390 400
mKIAA0 MNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPVEDLEMQEGCPEAQIGQQAQDDD
: :: . : : :... ... : .
mKIAA1 AKGGDKEPERIDEAQPSDVTLPAEDASNRQEPKAPASSKCLAHTSG-PQVDTASRLQGEG
650 660 670 680 690 700
410 420 430 440 450 460
mKIAA0 SSDSETEEPSVSQDPKDTSSQPSSTSHRPRAASCRATATWCTDSGSDDSRRWSDQLSLDE
.. : . .:::. . : .. ::. .. :.: . :. ::
mKIAA1 EVKGQPEPEARKQDPEKS---PVVSGDSPRGDVAQTEHQHLLGSSSTVGSCSLDNTRLDV
710 720 730 740 750 760
470 480 490 500 510
mKIAA0 KDGFIFVN--YSEGQTRAHLQGPLAHPHPNPIEARSYS-RLKPGYRWERQLVFRSKL-TM
. . :. .. . :....: : . . . .:. .: . . .... . .:
mKIAA1 ATAAMPVTPMATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVM
770 780 790 800 810 820
520 530 540 550 560 570
mKIAA0 HTAFDRKDNTHPAEVT-ALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGG
: . :. . .:: .: . .. : .. . . . . .:: ::.
mKIAA1 ATKPETDDKEKLKKVTQTLRSAALEDCALCQETVSSSELAAKTRDGDFEDPPEWVPDEAC
830 840 850 860 870 880
580 590 600 610 620 630
mKIAA0 DSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYSLQHER
:..:.. :.. .:.::::.::..::..:: .. . : .::::: .::.
mKIAA1 GFCTSCKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPF
890 900 910 920 930 940
640
mKIAA0 GAEDGPRNC
mKIAA1 YSDKTGM
950
>>mKIAA1255 ( 176 res) mbg10338 (176 aa)
initn: 162 init1: 162 opt: 223 Z-score: 193.7 bits: 44.2 E(): 1.2e-05
Smith-Waterman score: 223; 32.653% identity (34.409% ungapped) in 98 aa overlap (538-630:70-167)
510 520 530 540 550 560
mKIAA0 RQLVFRSKLTMHTAFDRKDNTHPAEVTALGVSKDHSRILVGDSRG-RVFSWSV-SDQPGR
. .. :. :....: .:...: . :
mKIAA1 PEYPLDKPDAEGNTVLLLAYMKGNANLCRAIVRSGVRLGVNNNQGVNIFNYQVATKQLLF
40 50 60 70 80 90
570 580 590 600 610 620
mKIAA0 SAADHWVKDE---GGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSP
: :. :..: :...:..: :.::::.::.:.:.::: . : .. ...:
mKIAA1 RLLDMLSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKP
100 110 120 130 140 150
630 640
mKIAA0 VRVCQNCYYSLQHERGAEDGPRNC
::::. :.
mKIAA1 VRVCNICFDVLTLGGVS
160 170
>>mKIAA1537 ( 628 res) mbg18407 (628 aa)
initn: 230 init1: 187 opt: 227 Z-score: 190.5 bits: 45.5 E(): 1.8e-05
Smith-Waterman score: 227; 44.444% identity (45.902% ungapped) in 63 aa overlap (571-633:559-619)
550 560 570 580 590 600
mKIAA0 DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG
:.::. . :. : .:::..:.:::::::
mKIAA1 ALQELGSKLCESKLKIDDIKEANKALQGLVWLKDKDATHCKLCEKEFSLSKRKHHCRNCG
530 540 550 560 570 580
610 620 630 640
mKIAA0 QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYSLQHERGAEDGPRNC
..::. :: ..:. . .:::::..:. :
mKIAA1 EIFCNACS--DNELPLPSSPKPVRVCDSCHAMLIQRCSSNMP
590 600 610 620
>>mKIAA4212 ( 600 res) mbg08227 (600 aa)
initn: 223 init1: 181 opt: 222 Z-score: 186.8 bits: 44.7 E(): 2.9e-05
Smith-Waterman score: 222; 43.333% identity (44.828% ungapped) in 60 aa overlap (571-630:531-588)
550 560 570 580 590 600
mKIAA0 DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG
:.::. . :. : ::...:.:::::::
mKIAA4 ALQEMGLHLSQSKLKMEDIKEVNKALKGHTWLKDDEATHCKQCEKDFSISRRKHHCRNCG
510 520 530 540 550 560
610 620 630 640
mKIAA0 QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYSLQHERGAEDGPRNC
..::. :: ..:. . .:::::..:.
mKIAA4 HIFCNTCS--SNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
570 580 590 600
>>mKIAA1362 ( 1407 res) mia41047 (1407 aa)
initn: 180 init1: 147 opt: 215 Z-score: 177.0 bits: 44.1 E(): 0.0001
Smith-Waterman score: 215; 40.278% identity (40.845% ungapped) in 72 aa overlap (563-634:1188-1258)
540 550 560 570 580 590
mKIAA0 VTALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTER
: . : :. : . : :. .:.:: :
mKIAA1 SSIEEYAKKRITFCPSRSLDEDSERKEEVSPLGAKAPIWIPDTRATMCMICTSEFTLTWR
1160 1170 1180 1190 1200 1210
600 610 620 630 640
mKIAA0 RHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYSLQHERGAEDGPRNC
::::: ::.. :: :: . . :: .. .:::..:. ::.
mKIAA1 RHHCRACGKIVCQACSSNKYGLDYLK-GQLARVCEHCFQELQKLDHQLSPRVGSPGNHKS
1220 1230 1240 1250 1260 1270
mKIAA1 PSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSTMSGYLYRSKGSKKPWKHLWFVIKN
1280 1290 1300 1310 1320 1330
>>mKIAA0305 ( 1536 res) mbg08215 (1536 aa)
initn: 201 init1: 170 opt: 214 Z-score: 175.8 bits: 44.0 E(): 0.00012
Smith-Waterman score: 214; 37.143% identity (38.235% ungapped) in 70 aa overlap (571-640:740-807)
550 560 570 580 590 600
mKIAA0 DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG
:: : . .: .:.:.:..:.:::::: ::
mKIAA0 DGSSFVTANKDSLPENKRKESLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACG
710 720 730 740 750 760
610 620 630 640
mKIAA0 QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYSLQHERGAEDGPRNC
..:: : . ... :. . .::: :: .... .. :
mKIAA0 KVFCGVCCNRKCKLQYLE--KEARVCVICYETINKAQAFERMMSPGGSCLKSNHSNECAT
770 780 790 800 810 820
mKIAA0 DQPLQETQTSSTPSPTTLPISALKQPNVEGPCSKEQKRVWFADGILPNGEVADTTKLSSG
830 840 850 860 870 880
646 residues in 1 query sequences
1768371 residues in 2168 library sequences
Scomplib [34t11]
start: Mon Mar 27 10:33:34 2006 done: Mon Mar 27 10:33:35 2006
Scan time: 0.810 Display time: 0.210
Function used was FASTA [version 3.4t11 Apr 17, 2002]