# /hgtech/tools/solaris8/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -Oon19334.fasta.nr -Q on19334.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 on19334, 787 aa vs /cdna2/lib/nr/nr library 2460750245 residues in 7145453 sequences statistics sampled from 60000 to 7141842 sequences Expectation_n fit: rho(ln(x))= 5.4768+/-0.000194; mu= 13.1399+/- 0.011 mean_var=98.2649+/-19.192, 0's: 35 Z-trim: 38 B-trim: 3780 in 2/63 Lambda= 0.129382 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7145453) gi|6226142|sp|Q99835|SMO_HUMAN Smoothened homolog ( 787) 5464 1030.7 0 gi|114615901|ref|XP_519371.2| PREDICTED: smoothene ( 786) 5406 1019.9 0 gi|109068129|ref|XP_001093150.1| PREDICTED: simila ( 786) 5382 1015.4 0 gi|194209886|ref|XP_001501725.2| PREDICTED: smooth ( 937) 5192 980.0 0 gi|61810383|ref|XP_586374.1| PREDICTED: similar to ( 780) 5105 963.7 0 gi|148681819|gb|EDL13766.1| smoothened homolog (Dr ( 793) 5089 960.7 0 gi|66364515|gb|AAH96028.1| Smoothened homolog (Dro ( 793) 5087 960.3 0 gi|6226144|sp|P97698|SMO_RAT Smoothened homolog pr ( 793) 5082 959.4 0 gi|6226143|sp|P56726|SMO_MOUSE Smoothened homolog ( 793) 5081 959.2 0 gi|149065157|gb|EDM15233.1| smoothened homolog (Dr ( 793) 5076 958.3 0 gi|126340687|ref|XP_001366826.1| PREDICTED: simila ( 785) 4948 934.4 0 gi|73975801|ref|XP_539381.2| PREDICTED: similar to ( 720) 4560 861.9 0 gi|114615903|ref|XP_001155311.1| PREDICTED: smooth ( 683) 4412 834.3 0 gi|149411719|ref|XP_001509776.1| PREDICTED: simila ( 697) 4404 832.8 0 gi|6226140|sp|O42224|SMO_CHICK Smoothened homolog ( 794) 3894 737.7 3.9e-210 gi|197245768|gb|AAI68525.1| Unknown (protein for M ( 815) 3695 700.5 6.1e-199 gi|13194566|gb|AAK15464.1|AF302766_1 smoothened [X ( 814) 3684 698.5 2.5e-198 gi|15077855|gb|AAK83380.1|AF395809_1 smoothened [D ( 808) 3600 682.8 1.3e-193 gi|56207858|emb|CAI20756.1| smoothened homolog (Dr ( 822) 3600 682.8 1.3e-193 gi|13735856|gb|AAK37404.1| smoothened [Danio rerio ( 822) 3586 680.2 8.1e-193 gi|118081892|ref|XP_414970.2| PREDICTED: similar t ( 692) 3327 631.8 2.6e-178 gi|28856222|gb|AAH48091.1| Smo protein [Mus muscul ( 439) 2826 538.1 2.6e-150 gi|146324972|gb|ABI95493.2| smoothened [Lytechinus ( 815) 2335 446.7 1.6e-122 gi|26348965|dbj|BAC38122.1| unnamed protein produc ( 360) 2292 438.3 2.3e-120 gi|70571201|dbj|BAE06698.1| smoothened [Ciona inte ( 691) 2228 426.6 1.5e-116 gi|27543373|gb|AAO13167.1| smoothened [Equus cabal ( 306) 1996 383.0 8.9e-104 gi|20988114|gb|AAH30377.1| Smo protein [Mus muscul ( 310) 1928 370.3 5.9e-100 gi|108877479|gb|EAT41704.1| conserved hypothetical ( 967) 1918 368.9 4.8e-99 gi|66532483|ref|XP_395373.2| PREDICTED: similar to (1059) 1918 368.9 5.2e-99 gi|167874235|gb|EDS37618.1| smoothened [Culex quin (1063) 1905 366.5 2.8e-98 gi|156219234|gb|EDO40119.1| predicted protein [Nem ( 529) 1875 360.6 8.2e-97 gi|156542961|ref|XP_001602300.1| PREDICTED: simila ( 982) 1789 344.8 8.7e-92 gi|47218492|emb|CAF97226.1| unnamed protein produc ( 789) 1763 339.9 2.1e-90 gi|27819924|gb|AAO25003.1| LD34308p [Drosophila me (1036) 1699 328.1 1e-86 gi|6226141|sp|P91682|SMO_DROME Protein smoothened (1036) 1699 328.1 1e-86 gi|194173503|gb|EDW87114.1| GE16703 [Drosophila ya (1036) 1695 327.3 1.7e-86 gi|194189624|gb|EDX03200.1| GD23013 [Drosophila si (1034) 1694 327.1 2e-86 gi|194123329|gb|EDW45372.1| GM16729 [Drosophila se (1034) 1694 327.1 2e-86 gi|190660014|gb|EDV57206.1| GG24709 [Drosophila er (1036) 1692 326.7 2.5e-86 gi|194161235|gb|EDW76136.1| GK15298 [Drosophila wi (1056) 1684 325.3 7.2e-86 gi|190618007|gb|EDV33531.1| GF20630 [Drosophila an (1027) 1679 324.3 1.4e-85 gi|194148341|gb|EDW64039.1| GJ24666 [Drosophila vi (1004) 1677 323.9 1.7e-85 gi|193905118|gb|EDW03985.1| GH11546 [Drosophila gr (1069) 1676 323.8 2.1e-85 gi|193912364|gb|EDW11231.1| GI17035 [Drosophila mo (1052) 1670 322.6 4.4e-85 gi|194114820|gb|EDW36863.1| GL25919 [Drosophila pe (1061) 1664 321.5 9.7e-85 gi|54645789|gb|EAL34527.1| smo [Drosophila pseudoo (1061) 1664 321.5 9.7e-85 gi|198416628|ref|XP_002124171.1| PREDICTED: simila ( 440) 1650 318.5 3.2e-84 gi|197276682|ref|NP_001127850.1| smoothened [Tribo ( 846) 1624 314.0 1.5e-82 gi|193634190|ref|XP_001949027.1| PREDICTED: simila ( 815) 1577 305.2 6.2e-80 gi|115722958|ref|XP_781487.2| PREDICTED: similar t ( 550) 1555 300.9 8.1e-79 >>gi|6226142|sp|Q99835|SMO_HUMAN Smoothened homolog prec (787 aa) initn: 5464 init1: 5464 opt: 5464 Z-score: 5511.9 bits: 1030.7 E(): 0 Smith-Waterman score: 5464; 100.000% identity (100.000% similar) in 787 aa overlap (1-787:1-787) 10 20 30 40 50 60 on1933 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP 10 20 30 40 50 60 70 80 90 100 110 120 on1933 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA 70 80 90 100 110 120 130 140 150 160 170 180 on1933 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN 130 140 150 160 170 180 190 200 210 220 230 240 on1933 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV 190 200 210 220 230 240 250 260 270 280 290 300 on1933 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT 250 260 270 280 290 300 310 320 330 340 350 360 on1933 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF 310 320 330 340 350 360 370 380 390 400 410 420 on1933 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 370 380 390 400 410 420 430 440 450 460 470 480 on1933 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW 430 440 450 460 470 480 490 500 510 520 530 540 on1933 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA 490 500 510 520 530 540 550 560 570 580 590 600 on1933 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV 550 560 570 580 590 600 610 620 630 640 650 660 on1933 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE 610 620 630 640 650 660 670 680 690 700 710 720 on1933 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG 670 680 690 700 710 720 730 740 750 760 770 780 on1933 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL 730 740 750 760 770 780 on1933 MDADSDF ::::::: gi|622 MDADSDF >>gi|114615901|ref|XP_519371.2| PREDICTED: smoothened is (786 aa) initn: 5310 init1: 5310 opt: 5406 Z-score: 5453.4 bits: 1019.9 E(): 0 Smith-Waterman score: 5406; 98.983% identity (99.619% similar) in 787 aa overlap (1-787:1-786) 10 20 30 40 50 60 on1933 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP :::::::::::::::::::::: : ::::.:::::::::::::::::::::::::::::: gi|114 MAAARPARGPELPLLGLLLLLL-GGPGRGSASSGNATGPGPRSAGGSARRSAAVTGPPPP 10 20 30 40 50 70 80 90 100 110 120 on1933 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA 60 70 80 90 100 110 130 140 150 160 170 180 on1933 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN 120 130 140 150 160 170 190 200 210 220 230 240 on1933 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV 180 190 200 210 220 230 250 260 270 280 290 300 on1933 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT 240 250 260 270 280 290 310 320 330 340 350 360 on1933 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF 300 310 320 330 340 350 370 380 390 400 410 420 on1933 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 360 370 380 390 400 410 430 440 450 460 470 480 on1933 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW 420 430 440 450 460 470 490 500 510 520 530 540 on1933 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA 480 490 500 510 520 530 550 560 570 580 590 600 on1933 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV 540 550 560 570 580 590 610 620 630 640 650 660 on1933 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE 600 610 620 630 640 650 670 680 690 700 710 720 on1933 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG :::::::::: ::::::.:::::::::::::::::::::::::::::::::::::::::: gi|114 ISPELQKRLGWKKKRRKKKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG 660 670 680 690 700 710 730 740 750 760 770 780 on1933 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL ::::::::.::::::::::::::::::::::::::.:::::::::::::::::::::.:: gi|114 AGDSCRQGVWTLVSNPFCPEPSPPQDPFLPSAPAPMAWAHGRRQGLGPIHSRTNLMDAEL 720 730 740 750 760 770 on1933 MDADSDF ::::::: gi|114 MDADSDF 780 >>gi|109068129|ref|XP_001093150.1| PREDICTED: similar to (786 aa) initn: 5286 init1: 5286 opt: 5382 Z-score: 5429.2 bits: 1015.4 E(): 0 Smith-Waterman score: 5382; 98.475% identity (99.619% similar) in 787 aa overlap (1-787:1-786) 10 20 30 40 50 60 on1933 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP :::::::::::::::::::::: : .:::.:::::::::::::::::::::.::::::: gi|109 MAAARPARGPELPLLGLLLLLL-GGQSRGASSSGNATGPGPRSAGGSARRSAVVTGPPPP 10 20 30 40 50 70 80 90 100 110 120 on1933 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA 60 70 80 90 100 110 130 140 150 160 170 180 on1933 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN 120 130 140 150 160 170 190 200 210 220 230 240 on1933 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV 180 190 200 210 220 230 250 260 270 280 290 300 on1933 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|109 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARQEIVCRADGT 240 250 260 270 280 290 310 320 330 340 350 360 on1933 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF 300 310 320 330 340 350 370 380 390 400 410 420 on1933 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 360 370 380 390 400 410 430 440 450 460 470 480 on1933 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW 420 430 440 450 460 470 490 500 510 520 530 540 on1933 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA :::::::::::::::::::::.:.:::::::::::::::::::::::::::::::::::: gi|109 ERSFRDYVLCQANVTIGLPTKKPVPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA 480 490 500 510 520 530 550 560 570 580 590 600 on1933 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV 540 550 560 570 580 590 610 620 630 640 650 660 on1933 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE 600 610 620 630 640 650 670 680 690 700 710 720 on1933 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG 660 670 680 690 700 710 730 740 750 760 770 780 on1933 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL :::::::::::::::::::::::::::::::::::.::::::::::::::::::::..:: gi|109 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPTAWAHGRRQGLGPIHSRTNLMEAEL 720 730 740 750 760 770 on1933 MDADSDF ::::::: gi|109 MDADSDF 780 >>gi|194209886|ref|XP_001501725.2| PREDICTED: smoothened (937 aa) initn: 4622 init1: 4589 opt: 5192 Z-score: 5236.6 bits: 980.0 E(): 0 Smith-Waterman score: 5192; 96.041% identity (98.467% similar) in 783 aa overlap (7-787:156-937) 10 20 30 on1933 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNA :: ::: ::::::::: : :::::: :::: gi|194 RAEPETVPHPGLRLASIPGPGGGFHGRCPLAREPELQLLGLLLLLL-GGPGRGAALSGNA 130 140 150 160 170 180 40 50 60 70 80 90 on1933 TGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDS ::::::::::::::::::::::: :::::::::::::::::::::.:::.:::::::::: gi|194 TGPGPRSAGGSARRSAAVTGPPPLLSHCGRAAPCEPLRYNVCLGSALPYAATSTLLAGDS 190 200 210 220 230 240 100 110 120 130 140 150 on1933 DSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 DSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAI 250 260 270 280 290 300 160 170 180 190 200 210 on1933 VERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQ ::::::::::::::::.::::: :::::::::::::::.::::::::::::::::::::: gi|194 VERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQ 310 320 330 340 350 360 220 230 240 250 260 270 on1933 CQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 CQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFV 370 380 390 400 410 420 280 290 300 310 320 330 on1933 GSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 GSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLT 430 440 450 460 470 480 340 350 360 370 380 390 on1933 YAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 YAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKN 490 500 510 520 530 540 400 410 420 430 440 450 on1933 YRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 YRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFG 550 560 570 580 590 600 460 470 480 490 500 510 on1933 FLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLL :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|194 FLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLL 610 620 630 640 650 660 520 530 540 550 560 570 on1933 VEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 VEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKR 670 680 690 700 710 720 580 590 600 610 620 630 on1933 HELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQD .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 RELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQD 730 740 750 760 770 780 640 650 660 670 680 690 on1933 ISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAP .:::::::::::::.::::::::::::::.:::::::::::::::::::.:::::: :.: gi|194 VSVTPVATPVPPEEKANLWLVEAEISPELEKRLGRKKKRRKRKKEVCPLVPPPELHHPTP 790 800 810 820 830 840 700 710 720 730 740 750 on1933 AP--STIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPA :: :..::::::::::::::.::::::.:::::::::::::::::::: :: ::::::: gi|194 APASSAVPRLPQLPRQKCLVATGAWGAGESCRQGAWTLVSNPFCPEPSPLQDLFLPSAPA 850 860 870 880 890 900 760 770 780 on1933 PVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF :.:::.::::::::::::::::..::::::::: gi|194 PTAWAQGRRQGLGPIHSRTNLMEAELMDADSDF 910 920 930 >>gi|61810383|ref|XP_586374.1| PREDICTED: similar to smo (780 aa) initn: 4900 init1: 4558 opt: 5105 Z-score: 5149.8 bits: 963.7 E(): 0 Smith-Waterman score: 5105; 94.564% identity (96.587% similar) in 791 aa overlap (1-787:1-780) 10 20 30 40 50 60 on1933 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP ::::: :::::: :::::::: : :::::: ::::: ::: ::::::::::::::::: gi|618 MAAARLARGPELLLLGLLLLL--GGPGRGAALSGNATRPGPWSAGGSARRSAAVTGPPPL 10 20 30 40 50 70 80 90 100 110 120 on1933 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: gi|618 LSHCGRAAPCEPLRYNVCLGSALPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA 60 70 80 90 100 110 130 140 150 160 170 180 on1933 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: : gi|618 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPN 120 130 140 150 160 170 190 200 210 220 230 240 on1933 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: gi|618 EVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV 180 190 200 210 220 230 250 260 270 280 290 300 on1933 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|618 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT 240 250 260 270 280 290 310 320 330 340 350 360 on1933 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|618 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF 300 310 320 330 340 350 370 380 390 400 410 420 on1933 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|618 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 360 370 380 390 400 410 430 440 450 460 470 480 on1933 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|618 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW 420 430 440 450 460 470 490 500 510 520 530 540 on1933 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA :::::::::::::::::::::.::::::::::::::::::::::::::::.::::::::: gi|618 ERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKA 480 490 500 510 520 530 550 560 570 580 590 600 on1933 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|618 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPV 540 550 560 570 580 590 610 620 630 640 650 660 on1933 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE ::::::::::::::::::::::::::::::::::::.:::::::::::::.::::::::: gi|618 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEKANLWLVEAE 600 610 620 630 640 650 670 680 690 700 710 on1933 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELH-P---PAPAPSTIPRLPQLPRQKCLVAA :::::.:::::::::::::::::::.:::::: : :: : :..::::::::::::::: gi|618 ISPELEKRLGRKKKRRKRKKEVCPLVPPPELHLPALGPASASSAVPRLPQLPRQKCLVAA 660 670 680 690 700 710 720 730 740 750 760 770 on1933 GAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLM :::: :.::: ::::::::::::: ::::::::::.:::::::::::::::: gi|618 GAWGPGESCRPGAWTLVSNPFCPE---------PSAPAPVAWAQGRRQGLGPIHSRTNLM 720 730 740 750 760 780 on1933 DTELMDADSDF ..::::::::: gi|618 EAELMDADSDF 770 780 >>gi|148681819|gb|EDL13766.1| smoothened homolog (Drosop (793 aa) initn: 4572 init1: 4347 opt: 5089 Z-score: 5133.6 bits: 960.7 E(): 0 Smith-Waterman score: 5089; 92.938% identity (97.478% similar) in 793 aa overlap (1-787:1-793) 10 20 30 40 50 on1933 MAAARPARGPEL-P--LLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGP :::.::.::::: : :: ::::.::: :::::: :::.:::::.::.::.::.. ::.: gi|148 MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP 10 20 30 40 50 60 60 70 80 90 100 110 on1933 PPPL-SHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAP :::: ::::::: ::::::::::::.::::::.::::::::::::::::::::::::::: gi|148 PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP 70 80 90 100 110 120 120 130 140 150 160 170 on1933 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|148 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE 130 140 150 160 170 180 180 190 200 210 220 230 on1933 GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA :: :::::::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|148 GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA 190 200 210 220 230 240 240 250 260 270 280 290 on1933 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR 250 260 270 280 290 300 300 310 320 330 340 350 on1933 ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK ::::::.:::::.::::::::::::::::::::::::::::::::::::::::::::::: gi|148 ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK 310 320 330 340 350 360 360 370 380 390 400 410 on1933 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG 370 380 390 400 410 420 420 430 440 450 460 470 on1933 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN 430 440 450 460 470 480 480 490 500 510 520 530 on1933 QAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|148 QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV 490 500 510 520 530 540 540 550 560 570 580 590 on1933 WTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSH ::::::::::::::::::.:::::::::::::::::::::.::::::::::::::::::: gi|148 WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH 550 560 570 580 590 600 600 610 620 630 640 650 on1933 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWL ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::.:: gi|148 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL 610 620 630 640 650 660 660 670 680 690 700 710 on1933 VEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST--IPRLPQLPRQKCLV :::::::::.:::::::::::::::::::.: :::: ::.:.: .::::::::::::: gi|148 VEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLV 670 680 690 700 710 720 720 730 740 750 760 770 on1933 AAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTN ::.:::.:.:::::::::::::::::::: ::::::.: :: .::.:: :::: :::::: gi|148 AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN 730 740 750 760 770 780 780 on1933 LMDTELMDADSDF ::..:..:::::: gi|148 LMEAEILDADSDF 790 >>gi|66364515|gb|AAH96028.1| Smoothened homolog (Drosoph (793 aa) initn: 4570 init1: 4345 opt: 5087 Z-score: 5131.6 bits: 960.3 E(): 0 Smith-Waterman score: 5087; 92.938% identity (97.352% similar) in 793 aa overlap (1-787:1-793) 10 20 30 40 50 on1933 MAAARPARGPEL-P--LLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGP :::.::.::::: : :: ::::.::: :::::: :::.:::::.::.::.::.. ::.: gi|663 MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP 10 20 30 40 50 60 60 70 80 90 100 110 on1933 PPPL-SHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAP :::: ::::::: ::::::::::::.::::::.::::::::::::::::::::::::::: gi|663 PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP 70 80 90 100 110 120 120 130 140 150 160 170 on1933 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|663 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE 130 140 150 160 170 180 180 190 200 210 220 230 on1933 GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA :: :::::::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|663 GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA 190 200 210 220 230 240 240 250 260 270 280 290 on1933 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|663 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR 250 260 270 280 290 300 300 310 320 330 340 350 on1933 ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK ::::::.:::::.::::::::::::::::::::::::::::::::::::::::::::::: gi|663 ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK 310 320 330 340 350 360 360 370 380 390 400 410 on1933 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|663 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG 370 380 390 400 410 420 420 430 440 450 460 470 on1933 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|663 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN 430 440 450 460 470 480 480 490 500 510 520 530 on1933 QAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|663 QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV 490 500 510 520 530 540 540 550 560 570 580 590 on1933 WTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSH ::::::::::::::::::.:::::::::::::::::::::.::::::::::::::::::: gi|663 WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH 550 560 570 580 590 600 600 610 620 630 640 650 on1933 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWL ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::.:: gi|663 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL 610 620 630 640 650 660 660 670 680 690 700 710 on1933 VEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST--IPRLPQLPRQKCLV :::::::::.::::::::::::::::::: : :::: ::.:.: .::::::::::::: gi|663 VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV 670 680 690 700 710 720 720 730 740 750 760 770 on1933 AAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTN ::.:::.:.:::::::::::::::::::: ::::::.: :: .::.:: :::: :::::: gi|663 AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN 730 740 750 760 770 780 780 on1933 LMDTELMDADSDF ::..:..:::::: gi|663 LMEAEILDADSDF 790 >>gi|6226144|sp|P97698|SMO_RAT Smoothened homolog precur (793 aa) initn: 4569 init1: 4332 opt: 5082 Z-score: 5126.5 bits: 959.4 E(): 0 Smith-Waterman score: 5082; 93.064% identity (97.226% similar) in 793 aa overlap (1-787:1-793) 10 20 30 40 50 on1933 MAAARPARGPEL-P--LLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGP :::.::.::::: : :: ::::.::: ::::: :::.::::::::::::::.: ::.: gi|622 MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSP 10 20 30 40 50 60 60 70 80 90 100 110 on1933 PPPL-SHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAP :::: ::::::: ::::::::::::.::::::.::::::::::::::.:::::::::::: gi|622 PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAP 70 80 90 100 110 120 120 130 140 150 160 170 on1933 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|622 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE 130 140 150 160 170 180 180 190 200 210 220 230 on1933 GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA :: :::::::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|622 GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA 190 200 210 220 230 240 240 250 260 270 280 290 on1933 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR 250 260 270 280 290 300 300 310 320 330 340 350 on1933 ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK ::::::.:::::.::::::::::::::::::::::::::::::::::::::::::::::: gi|622 ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK 310 320 330 340 350 360 360 370 380 390 400 410 on1933 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG 370 380 390 400 410 420 420 430 440 450 460 470 on1933 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN 430 440 450 460 470 480 480 490 500 510 520 530 on1933 QAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|622 QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV 490 500 510 520 530 540 540 550 560 570 580 590 on1933 WTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSH ::::::::::::::::::.:::::::::::::::::::::.::::::::::::::::::: gi|622 WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH 550 560 570 580 590 600 600 610 620 630 640 650 on1933 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWL :::::::::.::::::::::::::::::::::::::::::.::::::::::::::::::: gi|622 DGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWL 610 620 630 640 650 660 660 670 680 690 700 710 on1933 VEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST--IPRLPQLPRQKCLV :::::::::.:::::::::::::::::::.: :::: ::.:.: .::::::::::::: gi|622 VEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLV 670 680 690 700 710 720 720 730 740 750 760 770 on1933 AAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTN ::.:::.:. :::::::.::::::::::: ::::::.: :: .::.:: :::: :::::: gi|622 AANAWGTGEPCRQGAWTVVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN 730 740 750 760 770 780 780 on1933 LMDTELMDADSDF ::..::.:::::: gi|622 LMEAELLDADSDF 790 >>gi|6226143|sp|P56726|SMO_MOUSE Smoothened homolog prec (793 aa) initn: 4565 init1: 4339 opt: 5081 Z-score: 5125.5 bits: 959.2 E(): 0 Smith-Waterman score: 5081; 92.812% identity (97.352% similar) in 793 aa overlap (1-787:1-793) 10 20 30 40 50 on1933 MAAARPARGPEL-P--LLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGP :::.::.::::: : :: ::::.::: :::::: :::.:::::.::.::.::.. ::.: gi|622 MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRNVPVTSP 10 20 30 40 50 60 60 70 80 90 100 110 on1933 PPPL-SHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAP :::: ::::::: ::::::::::::.::::::.::::::::::::::::::::::::::: gi|622 PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP 70 80 90 100 110 120 120 130 140 150 160 170 on1933 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|622 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE 130 140 150 160 170 180 180 190 200 210 220 230 on1933 GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA :: :::::::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|622 GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA 190 200 210 220 230 240 240 250 260 270 280 290 on1933 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: gi|622 FGAVTGLCTLFTLATFVADWRNSNRLPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR 250 260 270 280 290 300 300 310 320 330 340 350 on1933 ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK ::::::.:::::.::::::::::::::::::::::::::::::::::::::::::::::: gi|622 ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK 310 320 330 340 350 360 360 370 380 390 400 410 on1933 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG 370 380 390 400 410 420 420 430 440 450 460 470 on1933 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|622 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN 430 440 450 460 470 480 480 490 500 510 520 530 on1933 QAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|622 QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV 490 500 510 520 530 540 540 550 560 570 580 590 on1933 WTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSH ::::::::::::::::::.:::::::::::::::::::::.::::::::::::::::::: gi|622 WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH 550 560 570 580 590 600 600 610 620 630 640 650 on1933 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWL ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::.:: gi|622 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL 610 620 630 640 650 660 660 670 680 690 700 710 on1933 VEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST--IPRLPQLPRQKCLV :::::::::.:::::::::::::::::::.: :::: ::.:.: .::::::::::::: gi|622 VEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLV 670 680 690 700 710 720 720 730 740 750 760 770 on1933 AAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTN ::.:::.:.:::::::::::::::::::: ::::::.: :: .::.:: :::: :::::: gi|622 AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN 730 740 750 760 770 780 780 on1933 LMDTELMDADSDF ::..:..:::::: gi|622 LMEAEILDADSDF 790 >>gi|149065157|gb|EDM15233.1| smoothened homolog (Drosop (793 aa) initn: 4563 init1: 4326 opt: 5076 Z-score: 5120.5 bits: 958.3 E(): 0 Smith-Waterman score: 5076; 92.938% identity (97.100% similar) in 793 aa overlap (1-787:1-793) 10 20 30 40 50 on1933 MAAARPARGPEL-P--LLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGP :::.::.::::: : :: ::::.::: ::::: :::.::::::::::::::.: ::.: gi|149 MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSP 10 20 30 40 50 60 60 70 80 90 100 110 on1933 PPPL-SHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAP :::: ::::::: ::::::::::::.::::::.::::::::::::::.:::::::::::: gi|149 PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAP 70 80 90 100 110 120 120 130 140 150 160 170 on1933 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE ::::::::::::::::::::::::::::::::::::::::::::::::::::: ::.::: gi|149 RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCMPDHFPE 130 140 150 160 170 180 180 190 200 210 220 230 on1933 GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA :: :::::::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|149 GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA 190 200 210 220 230 240 240 250 260 270 280 290 on1933 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR 250 260 270 280 290 300 300 310 320 330 340 350 on1933 ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK ::::::.:::::.::::::::::::::::::::::::::::::::::::::::::::::: gi|149 ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK 310 320 330 340 350 360 360 370 380 390 400 410 on1933 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG 370 380 390 400 410 420 420 430 440 450 460 470 on1933 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN 430 440 450 460 470 480 480 490 500 510 520 530 on1933 QAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|149 QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV 490 500 510 520 530 540 540 550 560 570 580 590 on1933 WTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSH ::::::::::::::::::.:::::::::::::::::::::.::::::::::::::::::: gi|149 WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH 550 560 570 580 590 600 600 610 620 630 640 650 on1933 DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWL :::::::::.::::::::::::::::::::::::::::::.::::::::::::::::::: gi|149 DGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWL 610 620 630 640 650 660 660 670 680 690 700 710 on1933 VEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST--IPRLPQLPRQKCLV :::::::::.:::::::::::::::::::.: :::: ::.:.: .::::::::::::: gi|149 VEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLV 670 680 690 700 710 720 720 730 740 750 760 770 on1933 AAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTN ::.:::.:. :::::::.::::::::::: ::::::.: :: .::.:: :::: :::::: gi|149 AANAWGTGEPCRQGAWTVVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN 730 740 750 760 770 780 780 on1933 LMDTELMDADSDF ::..::.:::::: gi|149 LMEAELLDADSDF 790 787 residues in 1 query sequences 2460750245 residues in 7145453 library sequences Tcomplib [34.26] (4 proc) start: Fri Nov 7 21:09:27 2008 done: Fri Nov 7 21:13:21 2008 Total Scan time: 1026.350 Total Display time: 0.400 Function used was FASTA [version 34.26.5 April 26, 2007]