Miyakogusa Predicted Gene

chr3.CM0127.630.nc
Show Alignment: 

BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= chr3.CM0127.630.nc - phase: 0 
         (898 letters)

Database: trembl 
           6,964,485 sequences; 2,268,126,488 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

O24307_PEA (tr|O24307) Topoisomerase I OS=Pisum sativum GN=top1 ...  1050   0.0  
B2DDA7_CAMAC (tr|B2DDA7) Topoisomerase I OS=Camptotheca acuminat...   977   0.0  
B2DDA6_9GENT (tr|B2DDA6) Topoisomerase I OS=Ophiorrhiza japonica...   946   0.0  
B2DDA5_9GENT (tr|B2DDA5) Topoisomerase I OS=Ophiorrhiza liukiuen...   933   0.0  
B2DDA4_9GENT (tr|B2DDA4) Topoisomerase I OS=Ophiorrhiza pumila G...   930   0.0  
A7QDA6_VITVI (tr|A7QDA6) Chromosome undetermined scaffold_80, wh...   903   0.0  
A7PX10_VITVI (tr|A7PX10) Chromosome chr12 scaffold_36, whole gen...   875   0.0  
B2DDA8_CATRO (tr|B2DDA8) Topoisomerase I OS=Catharanthus roseus ...   870   0.0  
Q9FJ79_ARATH (tr|Q9FJ79) DNA topoisomerase I OS=Arabidopsis thal...   851   0.0  
Q84ZL5_ORYSJ (tr|Q84ZL5) Putative DNA topoisomerase I (Os08g0154...   846   0.0  
A2YRB7_ORYSI (tr|A2YRB7) Putative uncharacterized protein OS=Ory...   844   0.0  
Q9XGL1_DAUCA (tr|Q9XGL1) DNA topoisomerase I OS=Daucus carota GN...   842   0.0  
Q9ZSC8_TOBAC (tr|Q9ZSC8) Topoisomerase I OS=Nicotiana tabacum GN...   826   0.0  
A3BPR2_ORYSJ (tr|A3BPR2) Putative uncharacterized protein OS=Ory...   803   0.0  
A9T3W2_PHYPA (tr|A9T3W2) Predicted protein OS=Physcomitrella pat...   771   0.0  
Q8RX06_ARATH (tr|Q8RX06) Putative DNA topoisomerase I (Fragment)...   749   0.0  
A9T368_PHYPA (tr|A9T368) Predicted protein OS=Physcomitrella pat...   674   0.0  
A8IDM1_CHLRE (tr|A8IDM1) DNA topoisomerase I (Fragment) OS=Chlam...   623   e-176
Q56XA9_ARATH (tr|Q56XA9) DNA topoisomerase I (Fragment) OS=Arabi...   593   e-167
Q00XV7_OSTTA (tr|Q00XV7) Putative DNA topoisomerase I (ISS) OS=O...   516   e-144
B4L533_DROMO (tr|B4L533) GI21653 OS=Drosophila mojavensis GN=GI2...   504   e-141
B4NCJ2_DROWI (tr|B4NCJ2) GK25865 OS=Drosophila willistoni GN=GK2...   498   e-139
B4M707_DROVI (tr|B4M707) GJ16891 OS=Drosophila virilis GN=GJ1689...   493   e-137
Q494M1_DROME (tr|Q494M1) RE58921p (CG6146-PC, isoform C) OS=Dros...   491   e-137
Q17HT9_AEDAE (tr|Q17HT9) DNA topoisomerase type I OS=Aedes aegyp...   489   e-136
B3MR83_DROAN (tr|B3MR83) GF21232 OS=Drosophila ananassae GN=GF21...   489   e-136
B4ILF9_DROSE (tr|B4ILF9) GM19769 OS=Drosophila sechellia GN=GM19...   488   e-136
B3NTM5_DROER (tr|B3NTM5) GG17874 OS=Drosophila erecta GN=GG17874...   488   e-135
Q8IR39_DROME (tr|Q8IR39) CG6146-PB, isoform B OS=Drosophila mela...   487   e-135
B4GVZ4_DROPE (tr|B4GVZ4) GL14571 OS=Drosophila persimilis GN=GL1...   486   e-135
B4JLU3_DROGR (tr|B4JLU3) GH24453 OS=Drosophila grimshawi GN=GH24...   486   e-135
B5DMS2_DROPS (tr|B5DMS2) GA24044 OS=Drosophila pseudoobscura pse...   486   e-135
Q6T721_DANRE (tr|Q6T721) Mitochondrial topoisomerase I OS=Danio ...   481   e-133
B4PWL3_DROYA (tr|B4PWL3) GE17178 OS=Drosophila yakuba GN=GE17178...   481   e-133
B0WA62_CULQU (tr|B0WA62) Putative uncharacterized protein OS=Cul...   480   e-133
Q90WS0_FUGRU (tr|Q90WS0) Topoisomerase I alpha OS=Fugu rubripes ...   478   e-132
A8Q2Z1_BRUMA (tr|A8Q2Z1) DNA topoisomerase I, putative OS=Brugia...   476   e-132
Q7QH57_ANOGA (tr|Q7QH57) AGAP004078-PA OS=Anopheles gambiae GN=A...   474   e-131
Q6T722_CHICK (tr|Q6T722) Mitochondrial topoisomerase I OS=Gallus...   473   e-131
A9V5T5_MONBE (tr|A9V5T5) Predicted protein OS=Monosiga brevicoll...   471   e-130
Q86ST4_HUMAN (tr|Q86ST4) TOP1MT protein (Fragment) OS=Homo sapie...   464   e-128
A8KA78_HUMAN (tr|A8KA78) cDNA FLJ77890, highly similar to Homo s...   464   e-128
Q86V82_HUMAN (tr|Q86V82) Topoisomerase (DNA) I, mitochondrial OS...   464   e-128
Q1ED17_DANRE (tr|Q1ED17) Topoisomerase (DNA) I, like OS=Danio re...   463   e-128
Q5IFJ5_MACFA (tr|Q5IFJ5) TOP1 (Fragment) OS=Macaca fascicularis ...   463   e-128
Q24BB2_TETTH (tr|Q24BB2) Eukaryotic DNA topoisomerase I, catalyt...   462   e-128
B3S6N7_TRIAD (tr|B3S6N7) Putative uncharacterized protein (Fragm...   462   e-128
Q4T6N6_TETNG (tr|Q4T6N6) Chromosome 9 SCAF8684, whole genome sho...   461   e-127
A9Q1D5_PANTR (tr|A9Q1D5) Mitochondrial topoisomerase I OS=Pan tr...   460   e-127
Q90WS1_FUGRU (tr|Q90WS1) Topoisomerase I beta OS=Fugu rubripes G...   457   e-126
Q5CN58_CRYHO (tr|Q5CN58) DNA topoisomerase I OS=Cryptosporidium ...   457   e-126
Q5CY81_CRYPV (tr|Q5CY81) Eukaryotic DNA topoisomerase I (Fragmen...   456   e-126
P79994_CHICK (tr|P79994) DNA topoisomerase I OS=Gallus gallus PE...   456   e-126
Q4DTW1_TRYCR (tr|Q4DTW1) DNA topoisomerase IB, large subunit, pu...   456   e-126
Q6Y634_TRYCR (tr|Q6Y634) Type I topoisomerase OS=Trypanosoma cru...   455   e-126
A8XXL4_CAEBR (tr|A8XXL4) CBR-TOP-1 protein OS=Caenorhabditis bri...   454   e-125
Q8R4U6_MOUSE (tr|Q8R4U6) DNA topoisomerase I OS=Mus musculus GN=...   453   e-125
Q6IM78_RAT (tr|Q6IM78) Mitochondrial DNA topoisomerase I OS=Ratt...   450   e-124
A4S5R8_OSTLU (tr|A4S5R8) Predicted protein OS=Ostreococcus lucim...   449   e-124
B6ABX7_9CRYT (tr|B6ABX7) DNA topoisomerase I, putative OS=Crypto...   446   e-123
O60013_PNECA (tr|O60013) DNA topoisomerase I OS=Pneumocystis car...   444   e-122
B4MU44_DROWI (tr|B4MU44) GK23720 OS=Drosophila willistoni GN=GK2...   444   e-122
A7AUT4_BABBO (tr|A7AUT4) DNA topoisomerase OS=Babesia bovis GN=B...   442   e-122
Q4SKE8_TETNG (tr|Q4SKE8) Chromosome 13 SCAF14566, whole genome s...   441   e-121
Q9Y180_LEIIN (tr|Q9Y180) Topoisomerase I-like protein OS=Leishma...   438   e-121
Q9GPZ9_LEIIN (tr|Q9GPZ9) DNA topoisomerase I (DNA topoisomerase ...   438   e-121
B5Y3I3_PHATR (tr|B5Y3I3) Predicted protein OS=Phaeodactylum tric...   438   e-120
A4HB62_LEIBR (tr|A4HB62) DNA topoisomerase IB, large subunit OS=...   437   e-120
Q4Q2K0_LEIMA (tr|Q4Q2K0) DNA topoisomerase IB, large subunit OS=...   437   e-120
Q5KB99_CRYNE (tr|Q5KB99) Topoisomerase I (Putative uncharacteriz...   436   e-120
A8N6Y9_COPC7 (tr|A8N6Y9) Putative uncharacterized protein OS=Cop...   433   e-119
O59891_CRYNE (tr|O59891) Topoisomerase I OS=Cryptococcus neoform...   431   e-119
Q9NJG8_LEIDO (tr|Q9NJG8) DNA topoisomerase I OS=Leishmania donov...   429   e-118
A2Q8K2_ASPNC (tr|A2Q8K2) Catalytic activity: ATP-independent bre...   429   e-118
Q6FNH4_CANGA (tr|Q6FNH4) Similar to uniprot|P04786 Saccharomyces...   428   e-117
Q0CUT4_ASPTN (tr|Q0CUT4) DNA topoisomerase I OS=Aspergillus terr...   428   e-117
Q2URN8_ASPOR (tr|Q2URN8) DNA topoisomerase I OS=Aspergillus oryz...   427   e-117
A1D4R5_NEOFI (tr|A1D4R5) Topoisomerase I OS=Neosartorya fischeri...   427   e-117
Q4WK70_ASPFU (tr|Q4WK70) Topoisomerase I OS=Aspergillus fumigatu...   427   e-117
B0XN02_ASPFC (tr|B0XN02) Topoisomerase I OS=Aspergillus fumigatu...   427   e-117
B5VRP8_YEAST (tr|B5VRP8) YOL006Cp-like protein OS=Saccharomyces ...   426   e-117
A6ZNK0_YEAS7 (tr|A6ZNK0) Topoisomerase I OS=Saccharomyces cerevi...   426   e-117
B2WCA4_PYRTR (tr|B2WCA4) DNA topoisomerase 1 OS=Pyrenophora trit...   426   e-117
B3LJ50_YEAS1 (tr|B3LJ50) DNA topoisomerase I OS=Saccharomyces ce...   426   e-117
Q75CB7_ASHGO (tr|Q75CB7) ACL008Cp OS=Ashbya gossypii GN=ACL008C ...   424   e-116
Q5BGS7_EMENI (tr|Q5BGS7) Putative uncharacterized protein OS=Eme...   424   e-116
Q875K2_EMENI (tr|Q875K2) Topoisomerase I OS=Emericella nidulans ...   423   e-116
Q1DXZ1_COCIM (tr|Q1DXZ1) Putative uncharacterized protein OS=Coc...   421   e-115
Q7Z012_9TRYP (tr|Q7Z012) Type IB DNA topoisomerase large subunit...   421   e-115
Q581U8_9TRYP (tr|Q581U8) DNA topoisomerase IB, large subunit OS=...   420   e-115
B4DYD2_HUMAN (tr|B4DYD2) cDNA FLJ50294, highly similar to DNA to...   420   e-115
A7TJW1_VANPO (tr|A7TJW1) Putative uncharacterized protein OS=Van...   419   e-115
B6QNQ2_PENMA (tr|B6QNQ2) Topoisomerase I OS=Penicillium marneffe...   417   e-114
A5DLX4_PICGU (tr|A5DLX4) Putative uncharacterized protein OS=Pic...   416   e-114
Q6CUB9_KLULA (tr|Q6CUB9) KLLA0C06116p OS=Kluyveromyces lactis GN...   416   e-114
A1CRV8_ASPCL (tr|A1CRV8) Topoisomerase I OS=Aspergillus clavatus...   416   e-114
B6H1W4_PENCH (tr|B6H1W4) Pc13g03270 protein OS=Penicillium chrys...   415   e-114
O13463_EMENI (tr|O13463) Topoisomerase I OS=Emericella nidulans ...   415   e-113
A0DKX8_PARTE (tr|A0DKX8) Chromosome undetermined scaffold_55, wh...   414   e-113
Q6C7R2_YARLI (tr|Q6C7R2) YALI0D26103p OS=Yarrowia lipolytica GN=...   413   e-113
Q2HDT9_CHAGB (tr|Q2HDT9) Putative uncharacterized protein OS=Cha...   413   e-113
A5E508_LODEL (tr|A5E508) DNA topoisomerase I OS=Lodderomyces elo...   412   e-113
Q0UUB0_PHANO (tr|Q0UUB0) Putative uncharacterized protein OS=Pha...   410   e-112
Q59XR0_CANAL (tr|Q59XR0) Likely DNA topoisomerase I OS=Candida a...   410   e-112
Q59WV6_CANAL (tr|Q59WV6) Likely DNA topoisomerase I OS=Candida a...   409   e-112
Q4V7M4_XENLA (tr|Q4V7M4) MGC115546 protein OS=Xenopus laevis GN=...   409   e-112
A7SLG4_NEMVE (tr|A7SLG4) Predicted protein OS=Nematostella vecte...   407   e-111
A3LUX2_PICST (tr|A3LUX2) DNA topoisomerase I OS=Pichia stipitis ...   405   e-110
A6S3Q9_BOTFB (tr|A6S3Q9) Putative uncharacterized protein OS=Bot...   402   e-110
A7EXF7_SCLS1 (tr|A7EXF7) Putative uncharacterized protein OS=Scl...   402   e-110
B2AY06_PODAN (tr|B2AY06) Predicted CDS Pa_1_9460 OS=Podospora an...   401   e-109
Q6FVE9_CANGA (tr|Q6FVE9) Similar to uniprot|P04786 Saccharomyces...   400   e-109
Q6BLX2_DEBHA (tr|Q6BLX2) DEHA2F09988p OS=Debaryomyces hansenii G...   398   e-108
A4R0K7_MAGGR (tr|A4R0K7) Putative uncharacterized protein OS=Mag...   397   e-108
Q7S0F7_NEUCR (tr|Q7S0F7) DNA topoisomerase I OS=Neurospora crass...   393   e-107
Q94705_PHYPO (tr|Q94705) DNA topoisomerase I OS=Physarum polycep...   389   e-106
Q56X27_ARATH (tr|Q56X27) DNA topoisomerase I (Fragment) OS=Arabi...   382   e-104
B6KM03_TOXGO (tr|B6KM03) DNA topoisomerase I, putative OS=Toxopl...   370   e-100
A5BM51_VITVI (tr|A5BM51) Putative uncharacterized protein OS=Vit...   360   3e-97
Q4SR65_TETNG (tr|Q4SR65) Chromosome 11 SCAF14528, whole genome s...   355   1e-95
Q1WWG8_DROME (tr|Q1WWG8) IP16129p (Fragment) OS=Drosophila melan...   333   4e-89
A6R590_AJECN (tr|A6R590) Putative uncharacterized protein OS=Aje...   329   6e-88
Q4N5U3_THEPA (tr|Q4N5U3) DNA topoisomerase I, putative OS=Theile...   325   1e-86
Q8RXI5_ARATH (tr|Q8RXI5) Putative DNA topoisomerase I (Fragment)...   325   1e-86
Q8I3Z9_PLAF7 (tr|Q8I3Z9) Topoisomerase I OS=Plasmodium falciparu...   314   2e-83
Q26024_PLAFA (tr|Q26024) Topoisomerase I OS=Plasmodium falciparu...   314   2e-83
Q4UDP8_THEAN (tr|Q4UDP8) DNA topoisomerase i, putative OS=Theile...   312   7e-83
B4E061_HUMAN (tr|B4E061) cDNA FLJ51170, highly similar to DNA to...   308   1e-81
Q7RE42_PLAYO (tr|Q7RE42) Eukaryotic DNA topoisomerase I, DNA bin...   308   1e-81
Q4YYG2_PLABE (tr|Q4YYG2) Topoisomerase I, putative (Fragment) OS...   306   4e-81
Q0V9D3_XENTR (tr|Q0V9D3) Putative uncharacterized protein (Fragm...   290   5e-76
A8PY85_MALGO (tr|A8PY85) Putative uncharacterized protein OS=Mal...   288   1e-75
A9A2H9_NITMS (tr|A9A2H9) 2-alkenal reductase OS=Nitrosopumilus m...   285   9e-75
B3TAG0_9CREN (tr|B3TAG0) Putative eukaryotic DNA topoisomerase I...   270   5e-70
B3T4E9_9CREN (tr|B3T4E9) Putative eukaryotic DNA topoisomerase I...   267   3e-69
A0RU10_CENSY (tr|A0RU10) DNA topoisomerase IB OS=Cenarchaeum sym...   263   6e-68
B3L6G4_PLAKH (tr|B3L6G4) Topoisomerase I, putative OS=Plasmodium...   250   5e-64
B3GD28_9CARA (tr|B3GD28) Topoisomerase I (Fragment) OS=Calosoma ...   246   4e-63
B3GD30_METCO (tr|B3GD30) Topoisomerase I (Fragment) OS=Metrius c...   246   7e-63
A5KB33_PLAVI (tr|A5KB33) Topoisomerase I, putative OS=Plasmodium...   243   5e-62
A0CF77_PARTE (tr|A0CF77) Chromosome undetermined scaffold_174, w...   241   2e-61
Q9D6H0_MOUSE (tr|Q9D6H0) Putative uncharacterized protein OS=Mus...   237   3e-60
B3GD25_AMPLE (tr|B3GD25) Topoisomerase I (Fragment) OS=Amphizoa ...   234   2e-59
B3GD27_9COLE (tr|B3GD27) Topoisomerase I (Fragment) OS=Macrogyru...   226   7e-57
Q5BXE0_SCHJA (tr|Q5BXE0) SJCHGC03473 protein (Fragment) OS=Schis...   216   8e-54
Q6IQI8_DANRE (tr|Q6IQI8) Top1l protein (Fragment) OS=Danio rerio...   215   1e-53
B6JVY3_SCHJP (tr|B6JVY3) DNA topoisomerase I OS=Schizosaccharomy...   201   2e-49
B3GD23_9DYTI (tr|B3GD23) Topoisomerase I (Fragment) OS=Laccophil...   198   2e-48
B4LSA9_DROVI (tr|B4LSA9) GJ16237 OS=Drosophila virilis GN=GJ1623...   196   7e-48
B3GD22_9COLE (tr|B3GD22) Topoisomerase I (Fragment) OS=Chauliogn...   194   3e-47
B3GD31_9CARA (tr|B3GD31) Topoisomerase I (Fragment) OS=Sirdenus ...   193   6e-47
B3GD21_9COLE (tr|B3GD21) Topoisomerase I (Fragment) OS=Prolixocu...   193   6e-47
B3GD43_9CARA (tr|B3GD43) Topoisomerase I (Fragment) OS=Bembidion...   192   1e-46
B6NV09_BRAFL (tr|B6NV09) Putative uncharacterized protein (Fragm...   192   1e-46
B3GD45_9CARA (tr|B3GD45) Topoisomerase I (Fragment) OS=Bembidion...   191   2e-46
B3GD39_9CARA (tr|B3GD39) Topoisomerase I (Fragment) OS=Bembidion...   191   2e-46
B3GD41_9CARA (tr|B3GD41) Topoisomerase I (Fragment) OS=Bembidion...   190   5e-46
B3GD42_9CARA (tr|B3GD42) Topoisomerase I (Fragment) OS=Bembidion...   190   5e-46
B3GD37_9CARA (tr|B3GD37) Topoisomerase I (Fragment) OS=Bembidion...   189   6e-46
B3GD38_9CARA (tr|B3GD38) Topoisomerase I (Fragment) OS=Bembidion...   189   8e-46
B3GD34_9CARA (tr|B3GD34) Topoisomerase I (Fragment) OS=Bembidion...   189   9e-46
B3GD33_9CARA (tr|B3GD33) Topoisomerase I (Fragment) OS=Bembidion...   189   9e-46
B3GD32_9CARA (tr|B3GD32) Topoisomerase I (Fragment) OS=Asaphidio...   189   1e-45
B3GD36_9CARA (tr|B3GD36) Topoisomerase I (Fragment) OS=Bembidion...   188   1e-45
B3GD35_9CARA (tr|B3GD35) Topoisomerase I (Fragment) OS=Bembidion...   188   1e-45
B3GD29_9CARA (tr|B3GD29) Topoisomerase I (Fragment) OS=Scaphinot...   188   2e-45
B4KJC7_DROMO (tr|B4KJC7) GI24443 OS=Drosophila mojavensis GN=GI2...   187   4e-45
B3GD20_9NEOP (tr|B3GD20) Topoisomerase I (Fragment) OS=Sialis sp...   182   1e-43
Q5C1T3_SCHJA (tr|Q5C1T3) SJCHGC05060 protein (Fragment) OS=Schis...   179   9e-43
B3GD24_9DYTI (tr|B3GD24) Topoisomerase I (Fragment) OS=Copelatus...   179   1e-42
Q4XMK5_PLACH (tr|Q4XMK5) Topoisomerase I, putative (Fragment) OS...   178   2e-42
B3GD26_9COLE (tr|B3GD26) Topoisomerase I (Fragment) OS=Dineutes ...   177   3e-42
Q941M6_ORYSA (tr|Q941M6) Topoisomerase I (Fragment) OS=Oryza sat...   165   2e-38
Q941M5_SPIOL (tr|Q941M5) Topoisomerase I (Fragment) OS=Spinacia ...   159   9e-37
Q7YXA0_LEIMA (tr|Q7YXA0) DNA topoisomerase I subunit A (Fragment...   156   5e-36
Q9BVT2_HUMAN (tr|Q9BVT2) Putative uncharacterized protein (Fragm...   132   1e-28
B3H4K2_ARATH (tr|B3H4K2) Uncharacterized protein At4g26701.1 OS=...   130   4e-28
Q8WZG1_CRYNE (tr|Q8WZG1) Topoisomerase I (Fragment) OS=Cryptococ...   127   3e-27
Q8WZG9_CRYNE (tr|Q8WZG9) Topoisomerase I (Fragment) OS=Cryptococ...   127   3e-27
Q8X232_CRYNE (tr|Q8X232) Topoisomerase I (Fragment) OS=Cryptococ...   127   3e-27
Q8WZF2_CRYNE (tr|Q8WZF2) Topoisomerase I (Fragment) OS=Cryptococ...   124   3e-26
B4F8X8_MAIZE (tr|B4F8X8) Putative uncharacterized protein OS=Zea...   119   2e-24
Q3TSR2_MOUSE (tr|Q3TSR2) Putative uncharacterized protein (Fragm...   110   4e-22
B3MVN1_DROAN (tr|B3MVN1) GF23753 OS=Drosophila ananassae GN=GF23...    99   2e-18
Q7YZP3_9TRYP (tr|Q7YZP3) Topoisomerase I subunit A (Fragment) OS...    98   3e-18
Q9NGZ9_LEIDO (tr|Q9NGZ9) Topoisomerase I (Fragment) OS=Leishmani...    93   1e-16
Q6LBJ1_MOUSE (tr|Q6LBJ1) Topoisomerase I (Fragment) OS=Mus muscu...    86   1e-14
Q28GG2_XENTR (tr|Q28GG2) Novel protein similar to topoisomerase ...    83   9e-14
Q504F2_DANRE (tr|Q504F2) Top1l protein (Fragment) OS=Danio rerio...    80   1e-12
Q8TBP3_HUMAN (tr|Q8TBP3) TOP1MT protein (Fragment) OS=Homo sapie...    75   2e-11
Q38EP5_9TRYP (tr|Q38EP5) DNA topoisomerase type IB small subunit...    73   9e-11
Q7Z011_9TRYP (tr|Q7Z011) Type IB DNA topoisomerase small subunit...    73   1e-10
Q70HS8_9TRYP (tr|Q70HS8) DNA topoisomerase I subunit B (Fragment...    73   1e-10
A4H3S7_LEIBR (tr|A4H3S7) DNA topoisomerase type IB small subunit...    72   2e-10
Q5RL92_TRYCR (tr|Q5RL92) Type IB topoisomerase small subunit OS=...    72   3e-10
Q4DUD0_TRYCR (tr|Q4DUD0) DNA topoisomerase type IB small subunit...    71   3e-10
Q3ULF5_MOUSE (tr|Q3ULF5) Putative uncharacterized protein (Fragm...    71   4e-10
Q95Z89_LEIMA (tr|Q95Z89) Possible DNA topoisomerase I-related pr...    71   4e-10
Q8WQM6_LEIDO (tr|Q8WQM6) DNA topoisomerase I-like protein (Small...    71   5e-10
A4HS02_LEIIN (tr|A4HS02) DNA topoisomerase type IB small subunit...    71   5e-10
Q46T09_RALEJ (tr|Q46T09) Putative uncharacterized protein OS=Ral...    55   2e-05
Q2HPH0_BOVIN (tr|Q2HPH0) Topoisomerase I (Fragment) OS=Bos tauru...    54   5e-05
Q6MBZ3_PARUW (tr|Q6MBZ3) Putative DNA topoisomerase I OS=Protoch...    53   1e-04
Q0KBJ9_RALEH (tr|Q0KBJ9) DNA Topoisomerase IB OS=Ralstonia eutro...    53   1e-04
B2JMY2_BURP8 (tr|B2JMY2) DNA topoisomerase OS=Burkholderia phyma...    51   5e-04
Q85387_VARV (tr|Q85387) Homolog of vaccinia virus CDS H6R OS=Var...    50   0.001
Q0N557_VARV (tr|Q0N557) Topoisomerase type IB OS=Variola virus G...    50   0.001
Q0NEE3_VARV (tr|Q0NEE3) Topoisomerase type IB OS=Variola virus G...    50   0.001

>O24307_PEA (tr|O24307) Topoisomerase I OS=Pisum sativum GN=top1 PE=2 SV=1
          Length = 892

 Score = 1050 bits (2716), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 569/915 (62%), Positives = 633/915 (69%), Gaps = 45/915 (4%)

Query: 1   MAVEASDKPNLPDNFDD-----EPLVFKRYTSKKSQLNSEVRKSTSQSHDGPSYRQNSDG 55
           MAVEASDK NLP  FDD     +PL FKR+ +KKS L+S+  K+TS S +G S RQ +D 
Sbjct: 1   MAVEASDKSNLPGKFDDDSDDDQPLSFKRH-AKKSPLHSQAIKTTSHSQEGRSNRQKTDV 59

Query: 56  PSSNGKTSSMQKGNIVPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSKLVSSRDKP 115
           P SNG+       N+ PS                 NS  N SS K P+ANS   S  DKP
Sbjct: 60  PLSNGQ-------NLKPS-----------------NSAVNTSSNKSPVANSNSPSLGDKP 95

Query: 116 KTLSEQKMSINVKEEKN-IKNCSKXXXXXXXXXH--KPLSARLKVNSHHDNKT-SPXXXX 171
           K L  Q ++++VK++   IK+ +K            KPLS+R K+ S+H +K  +P    
Sbjct: 96  KPLLGQNVTVDVKKQTTPIKHPTKGYCEGLEDDDDDKPLSSRWKIKSNHGSKVVAPVVNN 155

Query: 172 XXXXXXXXXXXXIPLSV----KINRNSNLATSSSNYDDSDKKPISKVQKERQNGSGITIK 227
                       +PLS     K+ RNSN  TSS NYDD+DKKPISKVQK+RQNGS  + K
Sbjct: 156 KSSQDSDSDDDVVPLSANLSAKLIRNSNSGTSSMNYDDTDKKPISKVQKKRQNGSTTSNK 215

Query: 228 QERASTLPVKRPIDNSNSLNSSMKKPKVSDSAASTKAKQVSGKSQPKIEXXXXXXXX--V 285
           Q++ STLP+KR + N +S +SS KK K+SDS  S K K VS K + K E          +
Sbjct: 216 QQKLSTLPIKRELGNCDSPHSSAKKSKISDSTTSIKTKHVSVKCEIKAEEEDDDDDDDEL 275

Query: 286 PISQRIKNXXXXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXXXXXXXL 345
           PIS R K                         GTT                         
Sbjct: 276 PISHRFKKSPTLSDKPSSTKKILAKVTKVNNSGTTSFKKQTKNKSKNPSVAQNIPNLRNF 335

Query: 346 LPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDY 405
             +   G +KWTTLVHNGVIFPPPY+PH VKMLY G+PVDLT +       YAVMRDTDY
Sbjct: 336 FLALVMG-RKWTTLVHNGVIFPPPYKPHGVKMLYMGRPVDLTPELRRGCYKYAVMRDTDY 394

Query: 406 MLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXX 465
           M KD+FKENFWNDWRKLLG+NHVIQNLKDCDFTPIYDWC                     
Sbjct: 395 MQKDRFKENFWNDWRKLLGRNHVIQNLKDCDFTPIYDWCQSEKEKKKQMTTEEKKALKEE 454

Query: 466 XXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDA 525
                    WAIVDGVK +VGNFRVEPPGLFRGRGEHPKMG+LK+RI PSDIVINIG +A
Sbjct: 455 KLKQEEKYTWAIVDGVKRRVGNFRVEPPGLFRGRGEHPKMGRLKKRIHPSDIVINIGSEA 514

Query: 526 PIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKAR 585
            +PECPIPGE WK+IR+DNTVTWL +W+DPINPKLFKYVFLAASSSLKGQSDKEKYEKAR
Sbjct: 515 QVPECPIPGEGWKDIRNDNTVTWLCYWSDPINPKLFKYVFLAASSSLKGQSDKEKYEKAR 574

Query: 586 MLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV 645
           MLKDYIGNIRA YTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV
Sbjct: 575 MLKDYIGNIRAYYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV 634

Query: 646 ENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
           ENVTRE PNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDK  GDDLFD LDT+KLN
Sbjct: 635 ENVTRETPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKGPGDDLFDKLDTNKLN 694

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
           AHLKELMPGLTAKVFRTFNASITLDD LNKDTKDGD  EKIVVYQHANKQVAIICNHQRS
Sbjct: 695 AHLKELMPGLTAKVFRTFNASITLDDKLNKDTKDGDAAEKIVVYQHANKQVAIICNHQRS 754

Query: 766 VSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKI 825
           VSKSH  QMT+LNEK+DELQ VLKEL+ DLDRAR               +L+ E LEKKI
Sbjct: 755 VSKSHSAQMTKLNEKIDELQDVLKELKVDLDRARKGKSPTKSSDGKSKRSLTPEVLEKKI 814

Query: 826 SQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKS---- 881
           SQTNAKIEKMQRDMKTK DLKTVALGTSKINYLDPRITVAWCKRHEVPIEK+F KS    
Sbjct: 815 SQTNAKIEKMQRDMKTKVDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKLFTKSLLQN 874

Query: 882 LLAKFTWAMDVDPDF 896
           LL ++ W    D + 
Sbjct: 875 LLGQWMWTQISDSEI 889


>B2DDA7_CAMAC (tr|B2DDA7) Topoisomerase I OS=Camptotheca acuminata GN=Top1 PE=2
           SV=1
          Length = 894

 Score =  977 bits (2525), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 539/919 (58%), Positives = 627/919 (68%), Gaps = 46/919 (5%)

Query: 1   MAVEASDKPNLPDNFD--DEPLVFKR--YTSKKSQLNSEVRKSTSQSHDGPSYRQNSDGP 56
           MAV+A  K  + D  D  DEPLVFKR   TSK +QLNS+ +KS SQ +DG S RQ SD P
Sbjct: 1   MAVQACVKEKMMDEIDEDDEPLVFKRSNATSKHNQLNSDTKKS-SQRYDGQSGRQVSDVP 59

Query: 57  SSNGKTSSMQKGNIVPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSKLVSSRDKPK 116
           S+NG++SS  KG     + +  P+ +     KAS S   AS    P+AN K+ SS D   
Sbjct: 60  STNGQSSSASKGKTTKLSSMKSPIASP----KASTSFAKAS----PVANPKVSSSSDDRS 111

Query: 117 TLSEQKMSINV-KEEKNIKNCSKXXXXXXXXXHKPLSARL-----KVNSHHDNK------ 164
             S ++ +INV KEEK + N +           KPLSARL     K +S++ NK      
Sbjct: 112 KHSSKQNTINVVKEEKELVNPA-AEPYGDSEDEKPLSARLFTGLTKGSSNNANKGLINSS 170

Query: 165 --TSPXXXXXXXXXXXXXXXXIPLSVKINRNSNLATSS-SNYDDSDKKPISKVQKERQNG 221
             + P                IPLS K    +N  TS+  +Y+  D K +  V   +QNG
Sbjct: 171 PASLPVPKPEINRYSDDSDDEIPLSSKFRLKANAGTSTVKSYESDDNKTL--VSNFQQNG 228

Query: 222 SGITIKQERASTLPV-KRPIDN-SNSLNSSMKKPKVSDSAASTKAKQVSGKSQPKIEXXX 279
           S   I +   S++ V KRP+    +S+ SS+KKPK+SD++     KQ S K++PK +   
Sbjct: 229 S---INRGSKSSIKVNKRPLGEVKSSVQSSVKKPKLSDASTPVNNKQASKKAEPKADDSD 285

Query: 280 XXXXXVPISQRIKNXXXXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXX 339
                VPISQR+K                           +                   
Sbjct: 286 DDH--VPISQRMKKSATSGNKSSTAKQKVTKVVSSSMKKASKKFKKVVKKSKYSKSSKVP 343

Query: 340 XXXXXLLPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAV 399
                   SSG+G KKW TLVHNGVIFPPPY+PH VKMLYKGKPVDLT +QEEVATM+AV
Sbjct: 344 P-------SSGEG-KKWNTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAV 395

Query: 400 MRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXX 459
           M DTDYM K KFKENF +DWRK+LGKNHVIQNL+DCDFTPIY+W                
Sbjct: 396 MLDTDYMTKSKFKENFMDDWRKILGKNHVIQNLEDCDFTPIYEWHQREKEKKKKMTAEEK 455

Query: 460 XXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVI 519
                          WAIV+GVKEKVGNFRVEPP LFRGRGEHPKMGKLK+ IRPSDI I
Sbjct: 456 KVLKEERLKQEEKYMWAIVNGVKEKVGNFRVEPPSLFRGRGEHPKMGKLKKCIRPSDITI 515

Query: 520 NIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
           NIGKDAPIPECPIPGE WKEIRHDNTVTWLAFWNDPI P+ FKYVFLAASSSLKGQSDKE
Sbjct: 516 NIGKDAPIPECPIPGESWKEIRHDNTVTWLAFWNDPIKPREFKYVFLAASSSLKGQSDKE 575

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVG 639
           KYEKAR+LKD+I  IRAAYTKDF SKDITK+QIAVATYLIDKLALRAGNEKDDDEADTVG
Sbjct: 576 KYEKARLLKDFIQGIRAAYTKDFASKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVG 635

Query: 640 CCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDML 699
           CCTLKVENV  + P+ LKF+FLGKDSI+Y+N VEVELPVY AI +F+  K+GGDDLFD L
Sbjct: 636 CCTLKVENVEPKPPSILKFDFLGKDSIRYQNEVEVELPVYKAIQQFRTGKRGGDDLFDKL 695

Query: 700 DTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAII 759
           DTSKLNAHLK LMPGLTAKVFRT+NASITLD+ML+++TK G+V EKIVVYQHANK+VAII
Sbjct: 696 DTSKLNAHLKGLMPGLTAKVFRTYNASITLDEMLSRETKGGNVAEKIVVYQHANKEVAII 755

Query: 760 CNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSE 819
           CNHQR+VSKSH  QMTRLN K+DEL+ +L  L+TDL RA+               NL+ E
Sbjct: 756 CNHQRTVSKSHPAQMTRLNGKIDELKGILDGLQTDLARAKKGKPPLEDADGKPKRNLTPE 815

Query: 820 ALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFN 879
           ALE+KI QTNAKIEKM+RD +TKE LKT+ALGTSKI+YLDPRITVAWCKRHEVPIEK+FN
Sbjct: 816 ALERKIGQTNAKIEKMERDKETKEGLKTIALGTSKISYLDPRITVAWCKRHEVPIEKVFN 875

Query: 880 KSLLAKFTWAMDVDPDFRF 898
           KSLLAKF W+MDVDP FRF
Sbjct: 876 KSLLAKFAWSMDVDPSFRF 894


>B2DDA6_9GENT (tr|B2DDA6) Topoisomerase I OS=Ophiorrhiza japonica GN=Top1 PE=2
           SV=1
          Length = 927

 Score =  946 bits (2446), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 527/940 (56%), Positives = 616/940 (65%), Gaps = 55/940 (5%)

Query: 1   MAVEASDKPNLPDNFDDE--PLVFKRY--TSKKSQLNSEVRKSTSQSHDGPSYRQNSDGP 56
           MAVEA   PNL ++ +D+  P++FKR    SK++Q NSE +K + Q H G S    SD  
Sbjct: 1   MAVEACT-PNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 59

Query: 57  SSNGKTSSMQKGNIVPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSK-LVSSRDKP 115
            +NG++SS QKG I PSAK TPPVK+ +   KASNS   AS    P ANSK   S+    
Sbjct: 60  PANGESSSAQKGRIQPSAK-TPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTA 118

Query: 116 KTLSEQKMSINVKEEK-NIKNCSKXXXXXXXXXHKPLSARL-----KVNSHHDNKT---S 166
           K  +  K S    E K ++               KPLSAR      K  S+H NK    S
Sbjct: 119 KQQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDS 178

Query: 167 PXXXXXXXXXXXXXXXXIPLSVKINRNSNLATSSS-NYDDSDKKPIS-KVQKERQNGS-G 223
                             PLS +    S+L  S+S +YD  +KKP++ KVQ   QNGS  
Sbjct: 179 CSIRRRVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQ---QNGSVS 235

Query: 224 ITIKQERASTLPVKRPIDNSNSLN-SSMKKPKVSDSAASTKAKQVSGKSQPKIEXXX--- 279
                 ++++L  KRP     SLN SS+KKPK+S    S   KQ + K +P+ +      
Sbjct: 236 RDGPMNKSASLSNKRPPGEVKSLNQSSVKKPKLSSPITSISNKQAAVKPEPEPKAEDDDD 295

Query: 280 --------------------XXXXXVPISQRIKNXXXXXXXXXXXXXXXXXXXXXXXXGT 319
                                    VPI+QRIK                           
Sbjct: 296 NIPLSQRGKKSQAATSKPKDEDDDNVPIAQRIKKSPASVSKSSAPVKKASTV-------V 348

Query: 320 TXXXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLY 379
           +                        + P SG+GQK WTTLVHNGVIFPPPY PH VKMLY
Sbjct: 349 SPSLKKVNKNSKKVIKKTAYTKSSKVPPGSGEGQK-WTTLVHNGVIFPPPYNPHGVKMLY 407

Query: 380 KGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTP 439
           K +P+ LT +QEEVATM+AVM DTDYM K +FKENF++DW+K+LGKNH IQNL+DCDF P
Sbjct: 408 KRQPITLTPEQEEVATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGP 467

Query: 440 IYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGR 499
           IY+W                               WAIVDGVKEKVGNFRVEPPGLFRGR
Sbjct: 468 IYEWHQQEKEKKKQMTTEEKKALKEDKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGR 527

Query: 500 GEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPK 559
           GEHPKMGKLK+RIRP DI INIGKDAPIPECPIPGERWKE+R+DNTVTWLAFW DPIN K
Sbjct: 528 GEHPKMGKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWIDPINQK 587

Query: 560 LFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTS-KDITKQQIAVATYL 618
            FKYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IRAAYTKDFT+ KD  K+QIAVATYL
Sbjct: 588 EFKYVFLAASSTLKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYL 647

Query: 619 IDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPV 678
           IDKLALRAGNEKDDDEADTVGCCTLKVENV    PN LKF+FLGKDSI+Y+N V+VE  V
Sbjct: 648 IDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAV 707

Query: 679 YNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK 738
           + AI +F+  K+G +DLFD LDTSKLNAHLKELMPGLTAKVFRT+NASITLDDML+K+TK
Sbjct: 708 FKAIQQFRSGKEGSEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETK 767

Query: 739 DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRA 798
            G+V EK+VVYQHANK+VAIICNHQR+VSKSH  QM+RLNEK+DEL+  ++EL+TDL R 
Sbjct: 768 GGEVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTAMEELKTDLSRV 827

Query: 799 RXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYL 858
           +               NL+ EALE+K++Q NAKIEKM+RD +TKEDLKTVALGTSKINYL
Sbjct: 828 KKGKPPSKGADGKPKRNLNPEALERKMAQINAKIEKMERDKETKEDLKTVALGTSKINYL 887

Query: 859 DPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           DPRITVAWCKRHEVPIEKIFNKSLLAKF W+MDVDP FRF
Sbjct: 888 DPRITVAWCKRHEVPIEKIFNKSLLAKFAWSMDVDPSFRF 927


>B2DDA5_9GENT (tr|B2DDA5) Topoisomerase I OS=Ophiorrhiza liukiuensis GN=Top1 PE=2
           SV=1
          Length = 926

 Score =  933 bits (2412), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 521/938 (55%), Positives = 609/938 (64%), Gaps = 52/938 (5%)

Query: 1   MAVEASDKPNLPDNFDDE--PLVFKRY--TSKKSQLNSEVRKSTSQSHDGPSYRQNSDGP 56
           MAVEA   PNL ++ +D+  P++FKR    SK++Q NSE +K + Q H G S    SD  
Sbjct: 1   MAVEACTTPNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 57  SSNGKTSSMQKGNIVPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSKL-VSSRDKP 115
            +NG++SS QKG I PSA+ TPPVK+ +   KASNS   AS    P ANSKL  S+    
Sbjct: 61  PANGESSSAQKGRIQPSAE-TPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTA 119

Query: 116 KTLSEQKMSINVKEEK-NIKNCSKXXXXXXXXXHKPLSARL-----KVNSHHDNKT---S 166
           K  +  K S    E K ++               KPL AR      K  S+H NK    S
Sbjct: 120 KQQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDS 179

Query: 167 PXXXXXXXXXXXXXXXXIPLSVKINRNSNLATSSS-NYDDSDKKPIS-KVQKERQNGSGI 224
                             PLS +    S+L  S+S +YD  +KKP++ KVQ   QNGS  
Sbjct: 180 CSIRRPVIEESEDSEDEKPLSRRFPSKSSLGESTSKSYDSDEKKPLATKVQ---QNGSAS 236

Query: 225 T-IKQERASTLPVKRPIDNSNSLN-SSMKKPKVSDSAASTKAKQVSGKSQPKIEX----- 277
                 ++++L  KR      SLN SS+KK K+S    S   KQ + K +PK E      
Sbjct: 237 RDGPMNKSASLLNKRAPGEVKSLNQSSLKKAKLSSPITSISNKQAAVKPEPKAEDDDDNI 296

Query: 278 ----------------XXXXXXXVPISQRIKNXXXXXXXXXXXXXXXXXXXXXXXXGTTX 321
                                   PISQRIK                           + 
Sbjct: 297 PLSQRGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTV-------VSP 349

Query: 322 XXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKG 381
                                  + P SG+GQK WTTLVHNGV+F PPY+PH VKMLYK 
Sbjct: 350 SLKKVNKKSKKVIKKTAYTKSSKVPPGSGEGQK-WTTLVHNGVMFLPPYKPHGVKMLYKX 408

Query: 382 KPVDLTADQEEVATMYAVMRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIY 441
           +P+ LT +QEEVATM+AVM DTDYM K +FKENF++DW+K+LGKNH +QNL+DCDF PIY
Sbjct: 409 QPLTLTPEQEEVATMFAVMLDTDYMTKPRFKENFFSDWKKMLGKNHTVQNLEDCDFGPIY 468

Query: 442 DWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGE 501
           +W                               WAIVDGVKEKVGNFRVEPPGLFRGRGE
Sbjct: 469 EWHQQEKEKRKQMTTEEKKALKEERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGE 528

Query: 502 HPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLF 561
           HPKMGKLK+RIRP DI INIGKDAPIPECPIPGERWKE+R+DNTVTWLAFWNDPIN K  
Sbjct: 529 HPKMGKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWNDPINQKEC 588

Query: 562 KYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTS-KDITKQQIAVATYLID 620
           KYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IRAAYTKDFT+ KD  K+QIAVATYLID
Sbjct: 589 KYVFLAASSTLKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLID 648

Query: 621 KLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYN 680
           KLALRAGNEKDDDEADTVGCCTLKVENV    PN LK +F+GKDSI+Y+N V+VE  V+ 
Sbjct: 649 KLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFK 708

Query: 681 AILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDG 740
           AI +F+  K+G  DLFD LDTSKLNAHLKELMPGLTAKVFRT+NASITLDDML+K+TK G
Sbjct: 709 AIQQFRSGKEGCADLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGG 768

Query: 741 DVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARX 800
            V EK+ VYQHANK+VAIICNHQR+VSKSH  QM+RLNEK+DEL+  L+EL+TDL RA+ 
Sbjct: 769 KVAEKVGVYQHANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKK 828

Query: 801 XXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDP 860
                         NL+ E+LE+KI+QTNAKIEKM+RD KTKEDLK VAL TSKI+YLDP
Sbjct: 829 GKPPAKGADGEPKRNLNPESLERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDP 888

Query: 861 RITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           RITVAWCKRHEVPIEKIFNKSLLAKF W+MDVDP FRF
Sbjct: 889 RITVAWCKRHEVPIEKIFNKSLLAKFAWSMDVDPSFRF 926


>B2DDA4_9GENT (tr|B2DDA4) Topoisomerase I OS=Ophiorrhiza pumila GN=Top1 PE=2 SV=1
          Length = 926

 Score =  930 bits (2404), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 519/938 (55%), Positives = 609/938 (64%), Gaps = 52/938 (5%)

Query: 1   MAVEASDKPNLPDNFDDE--PLVFKRY--TSKKSQLNSEVRKSTSQSHDGPSYRQNSDGP 56
           MAVEA   PNL ++ +D+  P++FKR    SK++Q NSE +K + Q H G S    SD  
Sbjct: 1   MAVEACTTPNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 57  SSNGKTSSMQKGNIVPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSKL-VSSRDKP 115
            +NG++SS QKG I PSA+ TPPVK+ +   KASNS   AS    P ANSKL  S+    
Sbjct: 61  PANGESSSAQKGRIQPSAE-TPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTA 119

Query: 116 KTLSEQKMSINVKEEK-NIKNCSKXXXXXXXXXHKPLSARL-----KVNSHHDNKT---S 166
           K  +  K S    E K ++               KPL AR      K  S+H NK    S
Sbjct: 120 KQQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDS 179

Query: 167 PXXXXXXXXXXXXXXXXIPLSVKINRNSNLATSSSNYDDSD-KKPIS-KVQKERQNGSGI 224
                             PLS +    S+L  S+S   DSD KKP++ KVQ   QNGS  
Sbjct: 180 CSIRRPVIEESEDSEDEKPLSRRFPSKSSLGESTSKSHDSDEKKPLAAKVQ---QNGSAS 236

Query: 225 T-IKQERASTLPVKRPIDNSNSLN-SSMKKPKVSDSAASTKAKQVSGKSQPKIEX----- 277
                 ++++L  KR      SLN SS+KKPK+S +  S   KQ + K +PK E      
Sbjct: 237 RDGPMNKSASLSNKRAPGEVKSLNQSSLKKPKLSSTITSISNKQAAVKPEPKAEDDDDNI 296

Query: 278 ----------------XXXXXXXVPISQRIKNXXXXXXXXXXXXXXXXXXXXXXXXGTTX 321
                                   PISQRIK                           + 
Sbjct: 297 PLSQRGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTV-------VSP 349

Query: 322 XXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKG 381
                                  + P SG+GQK WTTLVHNGV+FPPPY+PH VKMLYK 
Sbjct: 350 SLKKVNKKSKKVIKKTAYTKSSKVPPGSGEGQK-WTTLVHNGVMFPPPYKPHGVKMLYKR 408

Query: 382 KPVDLTADQEEVATMYAVMRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIY 441
           +P+ LT +QEEVATM+A M DTDYM K +FKENF++DW+K+LGKNH IQNL+DCDF PIY
Sbjct: 409 QPLTLTPEQEEVATMFAAMLDTDYMNKPRFKENFFSDWKKILGKNHTIQNLEDCDFGPIY 468

Query: 442 DWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGE 501
           +W                               WAIVDGVKEKVGNFRVEPPGLFRGRGE
Sbjct: 469 EWHQQEKEKKKQMTTEEKKALKEERLQLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGE 528

Query: 502 HPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLF 561
           HPK+GKLK+RIRP DI INIGKDAPIPECPIPGERWKE+R+DNTVTWLA+WNDP+N K  
Sbjct: 529 HPKVGKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPVNLKEC 588

Query: 562 KYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTS-KDITKQQIAVATYLID 620
           KYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IRAAYTKDFT+ KD  K+Q+AVATYLID
Sbjct: 589 KYVFLAASSTLKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQVAVATYLID 648

Query: 621 KLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYN 680
           KLALRAGNEKDDDEADTVGCCTLKVENV    PN LK +F+GKDSI+Y+N V+VE  V+ 
Sbjct: 649 KLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFK 708

Query: 681 AILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDG 740
           AI +F+  K+G +DLFD LDTSKLNAHLKELMPGLTAKVFRT+NASITLDDML+K+TK G
Sbjct: 709 AIQQFRSGKEGSEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGG 768

Query: 741 DVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARX 800
            V EK+ VYQ ANK+VAIICNHQR+VSKSH  QM+RLNEK+DEL+  L+EL+TDL RA+ 
Sbjct: 769 KVAEKVGVYQRANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKK 828

Query: 801 XXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDP 860
                         NL+ EALE+KI+QTNAKIEKM+RD KTKEDLK VAL TSKI+YLDP
Sbjct: 829 GKPPSKGDDGEPKRNLNPEALERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDP 888

Query: 861 RITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           RITVAWCKR EVPIEK+FNKSLLAKF WAMDVDP FRF
Sbjct: 889 RITVAWCKRQEVPIEKMFNKSLLAKFAWAMDVDPSFRF 926


>A7QDA6_VITVI (tr|A7QDA6) Chromosome undetermined scaffold_80, whole genome
           shotgun sequence OS=Vitis vinifera GN=GSVIVT00035757001
           PE=3 SV=1
          Length = 857

 Score =  903 bits (2333), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 465/719 (64%), Positives = 521/719 (72%), Gaps = 26/719 (3%)

Query: 184 IPLSVKINRNSNLATSSSNYDDSDKKPISKVQKERQNGSGITIKQERASTLPVKRPIDNS 243
           IPLS K    S+           +KKP+    K  QNG G   + +  + L  KRP+D  
Sbjct: 161 IPLSSKFQLKSD-----------EKKPLP--LKVNQNG-GTDKRDKSPTVLNKKRPLDGV 206

Query: 244 NS---LNSSMKKPKVS-DSAASTKAKQVSGKSQPKIEXXXXXXXXVPISQRIKNXXXXXX 299
           NS    +S +KKPK+S  SA   K    + K++PK+E        +PISQR+K       
Sbjct: 207 NSSLGQSSLVKKPKISGQSAQPFKVTHATAKAEPKVEDDDDDD--MPISQRMKKSGASSG 264

Query: 300 XXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKKWTTL 359
                              +T                        + PSSG+GQK WTTL
Sbjct: 265 NKPVPAKQKVTKVV----SSTSFKKTKDIKSKKMEKNSKYSKSTKVPPSSGEGQK-WTTL 319

Query: 360 VHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENFWNDW 419
           VHNGVIFPPPY+PH VKMLYKGKPVDLT +QEEVATM+AVM DTDYM K+KFKENF  DW
Sbjct: 320 VHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMQKEKFKENFMADW 379

Query: 420 RKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWAIVD 479
           RK+LGKNHVIQ L DCDFTPIY+W                               WAIVD
Sbjct: 380 RKILGKNHVIQRLDDCDFTPIYEWHQEEKEKKKQMSTEEKKTLKEEKLKLEEKYMWAIVD 439

Query: 480 GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGERWKE 539
           GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRI PSDI INIGK++ IPECPIPGE WKE
Sbjct: 440 GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIHPSDITINIGKNSQIPECPIPGESWKE 499

Query: 540 IRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYT 599
           ++HDNTVTWLAFWNDPINPK FKYVFLAASSSLKGQSDKEKYEKAR LK+YI +IRA YT
Sbjct: 500 VKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARKLKNYIKDIRATYT 559

Query: 600 KDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLKFN 659
           KDF SKDITK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV  E PN L+F+
Sbjct: 560 KDFVSKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVIPEPPNSLQFD 619

Query: 660 FLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKV 719
           FLGKDSI+YE TVEVELPVY AI +F+  K G DDLFD LDTSKLNAHLKELMPGLTAKV
Sbjct: 620 FLGKDSIRYEKTVEVELPVYKAIEQFRVGKSGSDDLFDKLDTSKLNAHLKELMPGLTAKV 679

Query: 720 FRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNE 779
           FRT+NASITLD+MLNKDTK+GDV +K+VVYQHANK+VAIICNHQR++SKSH  QMTRL E
Sbjct: 680 FRTYNASITLDEMLNKDTKEGDVAQKVVVYQHANKEVAIICNHQRTISKSHTAQMTRLTE 739

Query: 780 KLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDM 839
           K+DE++ VL  L+TDL RA+               NL+ EALE+KI+QTNAKIEKM+RD 
Sbjct: 740 KIDEMKGVLNGLKTDLARAK-KGKPPLKDADGKRRNLTPEALERKIAQTNAKIEKMERDK 798

Query: 840 KTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
            TKEDLKTVALGTSKINYLDPRI+VAWCKR EVPIEK+FNKSLLAKF WAMDV PDFRF
Sbjct: 799 DTKEDLKTVALGTSKINYLDPRISVAWCKRQEVPIEKVFNKSLLAKFAWAMDVPPDFRF 857


>A7PX10_VITVI (tr|A7PX10) Chromosome chr12 scaffold_36, whole genome shotgun
           sequence OS=Vitis vinifera GN=GSVIVT00025855001 PE=3
           SV=1
          Length = 789

 Score =  875 bits (2260), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 416/552 (75%), Positives = 458/552 (82%), Gaps = 1/552 (0%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYM 406
           P+SG+GQK WTTL HNGVIFPPPY+PH VKMLY G+PVDLT +QEEVATM+AVM+DTDY 
Sbjct: 239 PNSGEGQK-WTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYA 297

Query: 407 LKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
            K +F ENF NDWR  LGKNHVI+  + CDFTPIY+W                       
Sbjct: 298 TKPRFIENFMNDWRVRLGKNHVIKKFELCDFTPIYEWHEKEKEKKKQMTTEEKKALKEEK 357

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   WA+VDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RI PSDI INIGK+AP
Sbjct: 358 LKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRICPSDITINIGKEAP 417

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           +PECPIPGERWKE+RHDNTVTWLAFWNDPINPK FKYVFLAASSSLKGQSDKEKYEKAR+
Sbjct: 418 VPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARL 477

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LKDYI NIRA YTKDFT+KD  K+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE
Sbjct: 478 LKDYIQNIRATYTKDFTNKDTMKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 537

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNA 706
           NV    PNKL+F+FLGKDSI+Y NTVEVELPVY AI +F+  K GGDDLFD LDTSKLNA
Sbjct: 538 NVALVPPNKLEFDFLGKDSIRYFNTVEVELPVYKAIGQFKTGKSGGDDLFDKLDTSKLNA 597

Query: 707 HLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSV 766
           HLKELMPGLTAKVFRT+NASITLD+MLN++ + GD  EKIV+YQHANK+VAIICNHQRSV
Sbjct: 598 HLKELMPGLTAKVFRTYNASITLDEMLNREARGGDAMEKIVIYQHANKEVAIICNHQRSV 657

Query: 767 SKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKIS 826
           SKSHD QM+RL+EK+ ELQ VL EL+TDL RA+               N++ E LE+KI+
Sbjct: 658 SKSHDVQMSRLSEKMRELQGVLDELKTDLARAKKGKPPLKDSDGKPKKNMTPEVLERKIA 717

Query: 827 QTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
           QTN KIEKM+RDMKTKEDLKTVALGTSKINYLDPRI+VAWCKR EVPIEKIFNKSLLAKF
Sbjct: 718 QTNTKIEKMERDMKTKEDLKTVALGTSKINYLDPRISVAWCKRQEVPIEKIFNKSLLAKF 777

Query: 887 TWAMDVDPDFRF 898
            WAMDVDP FRF
Sbjct: 778 AWAMDVDPSFRF 789


>B2DDA8_CATRO (tr|B2DDA8) Topoisomerase I OS=Catharanthus roseus GN=Top1 PE=2
           SV=1
          Length = 910

 Score =  870 bits (2248), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 412/551 (74%), Positives = 459/551 (83%), Gaps = 3/551 (0%)

Query: 350 GDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKD 409
           G+G KKW  L HNGVIFPPPY+PH +KMLYKGKPVDLT +QEEVATM+AVM DTDYM K 
Sbjct: 361 GEG-KKWNKLEHNGVIFPPPYKPHGIKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMNKP 419

Query: 410 KFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXX 469
           +FKENF+ DW+K+LGKNHVIQNL++CDF+PIY+W                          
Sbjct: 420 RFKENFFGDWKKILGKNHVIQNLENCDFSPIYEWHQSEKEKKKQMTTEEKKALKEEKLKQ 479

Query: 470 XXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPE 529
                WA VDG KEKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRP DI INIGKDAPIPE
Sbjct: 480 EEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKDAPIPE 539

Query: 530 CPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
           CP+PGERWKE+RHDNTVTWLAFWNDPINPK FKYVFLAASS+LKG SDKEKYEKAR+LKD
Sbjct: 540 CPVPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSTLKGLSDKEKYEKARLLKD 599

Query: 590 YIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVT 649
           YI  IRAAYTKDF SKD TK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 
Sbjct: 600 YIQGIRAAYTKDFASKDPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE 659

Query: 650 REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLK 709
              PN LKF+FLGKDSI+Y+N VEVE  V+ AI +F+  K+G  DLFD+LDTSKLNAHLK
Sbjct: 660 PVPPNILKFDFLGKDSIRYQNEVEVEAAVFKAIQQFRSGKEGSSDLFDLLDTSKLNAHLK 719

Query: 710 ELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKS 769
           ELMPGLTAKVFRT+NASITLDDML+++TK GDV EK+VVYQHANK+VAIICNHQR+VSKS
Sbjct: 720 ELMPGLTAKVFRTYNASITLDDMLSRETKGGDVAEKVVVYQHANKEVAIICNHQRTVSKS 779

Query: 770 HDTQMTRLNEKLDELQAVLKELRTDLDRARXXX--XXXXXXXXXXXXNLSSEALEKKISQ 827
           H  QM RLNEK++EL+AV++EL++DL R +                 NL+ E+LEKKI+Q
Sbjct: 780 HSAQMLRLNEKIEELKAVVEELKSDLSRVKKGKPPLKSKNADGKPKRNLNPESLEKKIAQ 839

Query: 828 TNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFT 887
           TNAKIEKM+RD +TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFT
Sbjct: 840 TNAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFT 899

Query: 888 WAMDVDPDFRF 898
           WAMDVDP FRF
Sbjct: 900 WAMDVDPSFRF 910



 Score =  109 bits (272), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 119/322 (36%), Positives = 154/322 (47%), Gaps = 43/322 (13%)

Query: 1   MAVEASDKPNLPDNFD--DEPLVFKR--YTSKKSQLNSEVRKSTSQSHDGPSYRQNSDGP 56
           MAVEA   PNL D+ D  DEP+VFKR    SK+SQ NSE RK +SQ  DG S RQ  D  
Sbjct: 1   MAVEACPTPNLRDDMDEDDEPIVFKRNNSASKQSQTNSETRKVSSQKRDGQSVRQIYDSR 60

Query: 57  SSNGKTSSMQKGNIVPSAKVT-------------PPVKASVGISKASNSLGNASSAKLPL 103
            +NG++SS QKG +VP +K +               VK+ +   K S S    S      
Sbjct: 61  PANGESSSGQKGRMVPPSKPSQVKSPLSSPPSKPSQVKSPLSSPKVSTSSAKKSPVSSLP 120

Query: 104 ANSKLVSSRD-KPKTLSEQKMSINVKEEKN--------IKNCSKXXXXXXXXXHKPLSAR 154
           ANSK  +S   K K  ++ K +  +KEEK+        I N S+          KPLS R
Sbjct: 121 ANSKPSTSGSFKVKPFNQHKSATVIKEEKSSPLRLASAIINDSEDSDDG-----KPLSLR 175

Query: 155 LKVNSHHDNKTSPXXXXXXXXXXXXXXXXIPLSVKINRNSNLATSSSN-YDDSDKKPISK 213
              +S   N T+                  PLS +    S +  S+S  YD  D KP++K
Sbjct: 176 HSASSSKGN-TNQVSKEGSKPENEDSDDEKPLSSRFPLKSGVGESTSKAYDSDDDKPLAK 234

Query: 214 VQKERQNGSGITIKQ-ERASTLPVKRP---IDNSNSLNSSMKKPKVSDSAASTKAKQVSG 269
             K + NGS +   Q  + S +  KRP   I +SN L  S+KKPK+S   A T  KQ S 
Sbjct: 235 --KLQHNGSAMRDGQPNKYSNMSNKRPPGDIKSSNQL--SVKKPKLSSVTAPTNKKQASV 290

Query: 270 KSQPKIEXXXXXXXXVPISQRI 291
           K +PK E        +PISQRI
Sbjct: 291 KPEPKAE--DDDDDHLPISQRI 310


>Q9FJ79_ARATH (tr|Q9FJ79) DNA topoisomerase I OS=Arabidopsis thaliana
           GN=At5g55310 PE=2 SV=1
          Length = 917

 Score =  851 bits (2199), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 400/549 (72%), Positives = 453/549 (82%)

Query: 350 GDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKD 409
           GDGQKKW TL HNGVIFPPPY+ H VK+L++GKPVDLT +QEEVATM+AVMR+T+Y  K 
Sbjct: 363 GDGQKKWKTLQHNGVIFPPPYKRHGVKILFQGKPVDLTPEQEEVATMFAVMRETEYYKKP 422

Query: 410 KFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXX 469
           KF+ENFWNDWRKLLGKNH+I++L DCDFTPIY+W                          
Sbjct: 423 KFRENFWNDWRKLLGKNHMIKSLDDCDFTPIYEWYMQEKETKKQMTAEEKRIVKEEKLKQ 482

Query: 470 XXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPE 529
                WA++DGV+E++GNFRVEPPGLFRGRGEHPKMGKLK+RIRP DI INIGK+APIPE
Sbjct: 483 EEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKEAPIPE 542

Query: 530 CPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
           CPIPGERWKE++HDNTVTWLAFW+DPINPK FKYVFLAASSSLKGQSDKEKYEKAR L +
Sbjct: 543 CPIPGERWKEVKHDNTVTWLAFWSDPINPKEFKYVFLAASSSLKGQSDKEKYEKARKLHN 602

Query: 590 YIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVT 649
           +IG+IRAAYTKDF +KD+TK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV NV 
Sbjct: 603 HIGSIRAAYTKDFNNKDVTKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVGNVE 662

Query: 650 REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLK 709
              PNKLKF+FLGKDSI+Y NTVEVE  VY AI +FQ  K   DDLFD LDTSKLN HLK
Sbjct: 663 CIPPNKLKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDLFDELDTSKLNTHLK 722

Query: 710 ELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKS 769
           ELM GLTAKVFRT+NASITLD ML+K+T+DGDV EK+VVYQ ANK+VAIICNHQR+VSKS
Sbjct: 723 ELMAGLTAKVFRTYNASITLDLMLSKETRDGDVPEKVVVYQQANKEVAIICNHQRTVSKS 782

Query: 770 HDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           H  Q+ +L  K++EL+  +KEL  DLDRA+               NL+ EALEKKI QT 
Sbjct: 783 HGAQVEKLAVKIEELREQIKELNIDLDRAKKGRTPLMGSDGKRKRNLTPEALEKKIMQTQ 842

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
            KIEKM+RDM+TKED+KTVALGTSKINY+DPRITVAWCKRH+VPIEKIFNKSLLAKF WA
Sbjct: 843 GKIEKMERDMQTKEDMKTVALGTSKINYMDPRITVAWCKRHDVPIEKIFNKSLLAKFAWA 902

Query: 890 MDVDPDFRF 898
           MDVDP+FRF
Sbjct: 903 MDVDPEFRF 911


>Q84ZL5_ORYSJ (tr|Q84ZL5) Putative DNA topoisomerase I (Os08g0154600 protein)
           OS=Oryza sativa subsp. japonica GN=OJ1066_B03.125 PE=3
           SV=1
          Length = 916

 Score =  846 bits (2185), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 423/663 (63%), Positives = 484/663 (73%), Gaps = 13/663 (1%)

Query: 236 VKRPIDNSNSLNSSMKKPKVSDSAASTKAKQVSGKSQPKIEXXXXXXXXVPISQRIKNXX 295
           +KRPIDN+N  +S++KK + SD +AS   K+     +PK +        VP+SQR+K   
Sbjct: 267 IKRPIDNNNQTSSALKKARPSDVSASASVKR-----EPKADDNDN----VPLSQRLK--- 314

Query: 296 XXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKK 355
                                                            + P SG GQK 
Sbjct: 315 MGESSKSKPPAKNIVKKSPSSLKKDNKKMKMKMKTKKTMKNSQFSKTMKVPPGSGGGQK- 373

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           WTTLVH+GVIFPPPY+PH VKMLY G+PVDLT +QEEVATM+AVM+DTDY  K  F +NF
Sbjct: 374 WTTLVHSGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTFIDNF 433

Query: 416 WNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXW 475
           + DWRK+LGKNHVI+  + CDFTPIY+W                               W
Sbjct: 434 FTDWRKILGKNHVIKKFELCDFTPIYEWHLREKEKKKQMTSEEKKALKEEKLKQEEKYMW 493

Query: 476 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGE 535
           AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRI+PSDI INIGK APIPECPIPGE
Sbjct: 494 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAPIPECPIPGE 553

Query: 536 RWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIR 595
            WKE++HDNTVTWLAFWNDPI+ K FKYVFLAASS+LKGQSDKEKYEK+R LK ++  IR
Sbjct: 554 SWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYEKSRKLKHHVHKIR 613

Query: 596 AAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNK 655
             YTKDF SKD TK+QIAVATYLIDKLALRAGNEKD+DEA+TVGCCTLKV+NVT   PNK
Sbjct: 614 DTYTKDFRSKDKTKKQIAVATYLIDKLALRAGNEKDEDEAETVGCCTLKVDNVTCVPPNK 673

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           L+F+FLGKDSI+Y NTVEVEL VY AI +F+  KK G DLFD LDT++LNAHLK+LMPGL
Sbjct: 674 LQFDFLGKDSIRYFNTVEVELLVYKAIEEFRAGKKPGQDLFDKLDTTRLNAHLKDLMPGL 733

Query: 716 TAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMT 775
           TAKVFRT+NASITLDD+L+K+T+DG + EKI VYQ ANK+VAIICNHQRSVSKSHD+QMT
Sbjct: 734 TAKVFRTYNASITLDDILHKETEDGTLLEKIAVYQRANKEVAIICNHQRSVSKSHDSQMT 793

Query: 776 RLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKM 835
           RLNEK+DEL+A   EL+ DL + R               NL+ EA EKKISQ   KIEKM
Sbjct: 794 RLNEKIDELKAQRDELKADLSKVRKGKNLGNDKDGKPKRNLAPEAFEKKISQIETKIEKM 853

Query: 836 QRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPD 895
           + D K KEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL+AKF+WAMDVDPD
Sbjct: 854 EMDKKIKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLIAKFSWAMDVDPD 913

Query: 896 FRF 898
           FRF
Sbjct: 914 FRF 916


>A2YRB7_ORYSI (tr|A2YRB7) Putative uncharacterized protein OS=Oryza sativa subsp.
           indica GN=OsI_026860 PE=3 SV=1
          Length = 916

 Score =  844 bits (2180), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 422/663 (63%), Positives = 484/663 (73%), Gaps = 13/663 (1%)

Query: 236 VKRPIDNSNSLNSSMKKPKVSDSAASTKAKQVSGKSQPKIEXXXXXXXXVPISQRIKNXX 295
           +KRPIDN+N  +S++KK + SD +AS   K+     +PK +        VP+SQR+K   
Sbjct: 267 IKRPIDNNNQTSSALKKARPSDVSASASVKR-----EPKADDNDN----VPLSQRLK--- 314

Query: 296 XXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKK 355
                                                            + P SG GQK 
Sbjct: 315 MGESSKSKPPAKNIVKKSPSSLKKDNKKMKMKLKTKKTMKNSQFSKTMKVPPGSGGGQK- 373

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           WTTLVH+GVIFPPPY+PH VK+LY G+PVDLT +QEEVATM+AVM+DTDY  K  F +NF
Sbjct: 374 WTTLVHSGVIFPPPYKPHGVKILYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTFIDNF 433

Query: 416 WNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXW 475
           + DWRK+LGKNHVI+  + CDFTPIY+W                               W
Sbjct: 434 FTDWRKILGKNHVIKKFELCDFTPIYEWHLREKEKKKQMTSEEKKALKEEKLKQEEKYMW 493

Query: 476 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGE 535
           AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRI+PSDI INIGK APIPECPIPGE
Sbjct: 494 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAPIPECPIPGE 553

Query: 536 RWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIR 595
            WKE++HDNTVTWLAFWNDPI+ K FKYVFLAASS+LKGQSDKEKYEK+R LK ++  IR
Sbjct: 554 SWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYEKSRKLKHHVHKIR 613

Query: 596 AAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNK 655
             YTKDF SKD TK+QIAVATYLIDKLALRAGNEKD+DEA+TVGCCTLKV+NVT   PNK
Sbjct: 614 DTYTKDFRSKDKTKKQIAVATYLIDKLALRAGNEKDEDEAETVGCCTLKVDNVTCVPPNK 673

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           L+F+FLGKDSI+Y NTVEVEL VY AI +F+  KK G DLFD LDT++LNAHLK+LMPGL
Sbjct: 674 LQFDFLGKDSIRYFNTVEVELLVYKAIEEFRAGKKPGQDLFDKLDTTRLNAHLKDLMPGL 733

Query: 716 TAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMT 775
           TAKVFRT+NASITLDD+L+K+T+DG + EKI VYQ ANK+VAIICNHQRSVSKSHD+QMT
Sbjct: 734 TAKVFRTYNASITLDDILHKETEDGTLLEKIAVYQRANKEVAIICNHQRSVSKSHDSQMT 793

Query: 776 RLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKM 835
           RLNEK+DEL+A   EL+ DL + R               NL+ EA EKKISQ   KIEKM
Sbjct: 794 RLNEKIDELKAQRDELKADLSKVRKGKNLGNDKDGKPKRNLAPEAFEKKISQIETKIEKM 853

Query: 836 QRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPD 895
           + D K KEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL+AKF+WAMDVDPD
Sbjct: 854 EMDKKIKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLIAKFSWAMDVDPD 913

Query: 896 FRF 898
           FRF
Sbjct: 914 FRF 916


>Q9XGL1_DAUCA (tr|Q9XGL1) DNA topoisomerase I OS=Daucus carota GN=top1b PE=2 SV=1
          Length = 909

 Score =  842 bits (2174), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 480/920 (52%), Positives = 578/920 (62%), Gaps = 50/920 (5%)

Query: 13  DNFDDEPLVFKRYTS--KKSQLNSEVRKSTSQSHDGPSYRQNSDGPSSNGKTSSMQKGNI 70
           D+ DD+PL+FKR  +  K++Q     +K  S        R  SD  S+NG  S++QKG  
Sbjct: 6   DSEDDKPLIFKRSNTSVKQNQAKPRCQKIISAEAVWQVGRLISDVRSTNGHDSNVQKGKT 65

Query: 71  VPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSKL-VSSRDKPKTLSEQKMSINVKE 129
           VPS K +P V + +   KAS S   AS  K P+A++K   S  D+ +  S+Q  +  VK 
Sbjct: 66  VPSTKGSP-VVSPLASPKASVSSSKASQVKPPVASTKASTSGADQSRQNSQQNRTAIVKA 124

Query: 130 EK--NIKNCSKXXXXXXXXXHKPLSARL----------KVNSHHDNKTSPXXXXXXXXXX 177
           E+   I               KPL++RL          +VN    +              
Sbjct: 125 ERPSGIPKEEPDSGSEDSDDDKPLNSRLPVGGSKGSISEVNRRPSSSGPAAFEKDLGIKE 184

Query: 178 XXXXXXIPLSVKINRNSNLATSSSNYDDSDKKPISKVQKERQNGSGITIKQERASTLPVK 237
                 IPLS K  + SN   SS+ YD  + KP +   K RQNG+ +    +  ST   K
Sbjct: 185 EDSEDDIPLSHKFKQKSNAGESSNAYDSDEGKPFA--SKPRQNGTNVKDNVKNPSTAINK 242

Query: 238 RPIDNSNSLNSSMKKP--KVSDSAASTKAKQVSGKSQPKIEXXXXXXXXVPISQRIKNXX 295
           RP   S  +  S + P  K +      + ++++ K++PK E          ISQR+K   
Sbjct: 243 RP---SAEVKCSGQSPVKKATVQLHLHQVRKLTVKAEPKKEADDSDDDNATISQRVKKPA 299

Query: 296 XXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKK 355
                                   +                        + P SG+GQK 
Sbjct: 300 TPISKASDKKKSAVS--------VSSSLNKVNKNSKKITKSTQFSKSLKVPPGSGEGQK- 350

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRD-TDYMLKDKFKEN 414
           WTTLVHNGVIFPPPY+PH VKMLYK  PVDLT +QEEV  M AVM+  T+Y+ K  F+EN
Sbjct: 351 WTTLVHNGVIFPPPYKPHGVKMLYKESPVDLTLNQEEVH-MIAVMQILTEYLTKPVFREN 409

Query: 415 FWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 474
             NDW+ +LG+NH+I+NL DCDFTPIY+W                               
Sbjct: 410 VMNDWKIILGRNHIIKNLDDCDFTPIYEWFRLKKEKKKQMSAEEKKAVKEEKLKQEEKYM 469

Query: 475 WAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPG 534
           WA+VDGVKE VGNFRVEPPGLFRGR   PKMGKLK+RI PSDI INIGKDAPIPECPIPG
Sbjct: 470 WAVVDGVKENVGNFRVEPPGLFRGRESIPKMGKLKKRISPSDITINIGKDAPIPECPIPG 529

Query: 535 ERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNI 594
           E WKE+RHDNTVTWLA+WNDPIN K FKYVFLAASSSLKGQSDKEKYEKAR LK YI  I
Sbjct: 530 ESWKEVRHDNTVTWLAYWNDPINGKEFKYVFLAASSSLKGQSDKEKYEKARKLKGYIEGI 589

Query: 595 RAAYTKDFTSKDITKQQIAVATYLIDKLALRAGN----------------EKDDDEADTV 638
           R AYTKDF+SKD+TK+QIAVATYLIDKLALRAGN                EKDDDEADTV
Sbjct: 590 RTAYTKDFSSKDVTKRQIAVATYLIDKLALRAGNAVATYLIDKLALRAGNEKDDDEADTV 649

Query: 639 GCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDM 698
           GCCTLKVENV       LK +FL KDSI+Y+  VEVE+PV+ AI +F+  KKG D+LFD 
Sbjct: 650 GCCTLKVENVEPRNNPLLKLDFLPKDSIRYQKRVEVEIPVFKAIQQFRSGKKGSDNLFDK 709

Query: 699 LDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAI 758
           LDT KLNAHLKELMPGL+AKVFRT+NASITLD+MLNK+TK GDV +K+ VYQHANK+VAI
Sbjct: 710 LDTCKLNAHLKELMPGLSAKVFRTYNASITLDEMLNKETKGGDVSQKVAVYQHANKEVAI 769

Query: 759 ICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSS 818
           ICNHQRSVSKSH TQM RL+EK+++L+  ++EL+TDL RA+               N++ 
Sbjct: 770 ICNHQRSVSKSHSTQMMRLDEKINKLKNFIEELKTDLSRAKKGKPPLKGSDGKTKRNMNP 829

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           EA+EKKI+QTN KIEKM+RD +TKEDLKTVALGTSKINYLDPRITVAWCKR+EVPIEK+F
Sbjct: 830 EAIEKKIAQTNVKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRYEVPIEKMF 889

Query: 879 NKSLLAKFTWAMDVDPDFRF 898
           NKSLLAKF WAMDV+P FRF
Sbjct: 890 NKSLLAKFAWAMDVEPSFRF 909


>Q9ZSC8_TOBAC (tr|Q9ZSC8) Topoisomerase I OS=Nicotiana tabacum GN=TOP I PE=2 SV=1
          Length = 852

 Score =  826 bits (2134), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 485/895 (54%), Positives = 558/895 (62%), Gaps = 65/895 (7%)

Query: 1   MAVEASDKPNLPDNFDDE----PLVFKRYTSKKSQLNSEVRKSTSQSHDGPSYRQNSDGP 56
           MAVEA  K  L    DD+    PLVFKR ++   Q  S    S+SQ  DG S RQ SD  
Sbjct: 1   MAVEAFSKTKLMAEVDDDDDDMPLVFKRSSTTSKQNQS---NSSSQKQDGRSGRQASDVR 57

Query: 57  SSNGKTSSMQKGNIVPSAKVTPPVKASVGISKASNSLGNASSAKLPLANSK-LVSSRDKP 115
           S NG++SS +K     S+K +  V +     KAS S G  S    P  NS+   S+ ++ 
Sbjct: 58  SPNGQSSSAEKVKAGTSSKASRAV-SPFTSPKASPSSGRTS----PAPNSRPSASAGNQA 112

Query: 116 KTLSEQ--------KMSINVKEEKNIKNCSKXXXXXXXXXHKPLSARLKVNSH-----HD 162
           K +++Q        K ++  K E N                KPLSARL          H 
Sbjct: 113 KDVNQQSKIVPNEPKQAVEPKSEPN-------DEAEDSEDDKPLSARLSSGLSKSNSSHA 165

Query: 163 NK---TSPXXXXXXXXXXXXXXXXIPLSVKINRNSNLATSSSNYDDSDK-KPISKVQKER 218
           NK   TS                 IPL+ +    SN   S+S   +S++ KP     K R
Sbjct: 166 NKVLGTSASVQKSRPPKKEDSDDEIPLASRFQLKSNAGASTSKSSNSEEVKP-----KIR 220

Query: 219 QNGSGITIKQERASTLPVKRPIDNSNSLNSSMKKPKVSDSAASTKAKQVSGKSQPKIEXX 278
           QNG   T      + L  + P D S  L   +K           +  + S K + K E  
Sbjct: 221 QNGLPST------TVLSKRPPGDVSLLLRLQLKSLGFLMHLHLFRVSEASVKPEKKTEDD 274

Query: 279 XXXXXXVPISQRIKNXXXXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXX 338
                 VPISQRIK                                              
Sbjct: 275 DDD---VPISQRIKKSVASASKLSSAKKATKVVSSSMKTKKKLKKSKYSKSSK------- 324

Query: 339 XXXXXXLLPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYA 398
                 L PSSG+GQK WTTLVHNGVIFPPPY+PH VKMLYKGKPVDLT +QEEVATMYA
Sbjct: 325 ------LQPSSGEGQK-WTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYA 377

Query: 399 VMRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXX 458
           VM DTDYM K +FKENF NDWRK+LGKNHVIQNL DCDFTPIY+                
Sbjct: 378 VMLDTDYMSKLQFKENFMNDWRKILGKNHVIQNLDDCDFTPIYERPSSEKEKKKQMSTKR 437

Query: 459 XXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIV 518
                           WAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRP+DI 
Sbjct: 438 KRPLREEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPNDIT 497

Query: 519 INIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDK 578
           INIGK APIPECPIPGERWKE+RHDNTVTWLAFWNDPINP+ FKYVFLAASSSLKGQSDK
Sbjct: 498 INIGKGAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDK 557

Query: 579 EKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTV 638
           EKYEKAR LKDYI  IR+AYTKDFTSKD  K+QIAVATYLIDKLALRAGNEKDDDEADTV
Sbjct: 558 EKYEKARRLKDYIEGIRSAYTKDFTSKDPVKRQIAVATYLIDKLALRAGNEKDDDEADTV 617

Query: 639 GCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDM 698
           GCCTLKVENV    PN LKF+FLGKDSI+Y+N V V  PV+ AI  F+  KKGGDDLFD 
Sbjct: 618 GCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVAVYKPVFKAIQLFRSGKKGGDDLFDK 677

Query: 699 LDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAI 758
           LDTSKLNAHLKELMPGLTAKVFRT+NAS+TL+  L K T+ G++ EK+ VY  ANK+VAI
Sbjct: 678 LDTSKLNAHLKELMPGLTAKVFRTYNASVTLEQQLTKLTQGGELAEKVAVYNLANKEVAI 737

Query: 759 ICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSS 818
           ICNHQRSVSKSH  Q+++LNEK+DEL+A+L+E + DL RA+               NL+ 
Sbjct: 738 ICNHQRSVSKSHSVQISKLNEKIDELKALLEEFKVDLARAKKGKPPLKGADGKAKRNLAP 797

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVP 873
           EAL+KKI QTN KIE +++ ++TKE+LKTVALGTSKINYLDPRITVAWC+RH  P
Sbjct: 798 EALQKKIDQTNVKIENIEKQIETKEELKTVALGTSKINYLDPRITVAWCERHRFP 852


>A3BPR2_ORYSJ (tr|A3BPR2) Putative uncharacterized protein OS=Oryza sativa subsp.
           japonica GN=OsJ_025034 PE=4 SV=1
          Length = 960

 Score =  803 bits (2073), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 404/643 (62%), Positives = 464/643 (72%), Gaps = 13/643 (2%)

Query: 236 VKRPIDNSNSLNSSMKKPKVSDSAASTKAKQVSGKSQPKIEXXXXXXXXVPISQRIKNXX 295
           +KRPIDN+N  +S++KK + SD +AS   K+     +PK +        VP+SQR+K   
Sbjct: 267 IKRPIDNNNQTSSALKKARPSDVSASASVKR-----EPKADDNDN----VPLSQRLK--- 314

Query: 296 XXXXXXXXXXXXXXXXXXXXXXGTTXXXXXXXXXXXXXXXXXXXXXXXXLLPSSGDGQKK 355
                                                            + P SG GQK 
Sbjct: 315 MGESSKSKPPAKNIVKKSPSSLKKDNKKMKMKMKTKKTMKNSQFSKTMKVPPGSGGGQK- 373

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           WTTLVH+GVIFPPPY+PH VKMLY G+PVDLT +QEEVATM+AVM+DTDY  K  F +NF
Sbjct: 374 WTTLVHSGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTFIDNF 433

Query: 416 WNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXW 475
           + DWRK+LGKNHVI+  + CDFTPIY+W                               W
Sbjct: 434 FTDWRKILGKNHVIKKFELCDFTPIYEWHLREKEKKKQMTSEEKKALKEEKLKQEEKYMW 493

Query: 476 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGE 535
           AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRI+PSDI INIGK APIPECPIPGE
Sbjct: 494 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAPIPECPIPGE 553

Query: 536 RWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNIR 595
            WKE++HDNTVTWLAFWNDPI+ K FKYVFLAASS+LKGQSDKEKYEK+R LK ++  IR
Sbjct: 554 SWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYEKSRKLKHHVHKIR 613

Query: 596 AAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNK 655
             YTKDF SKD TK+QIAVATYLIDKLALRAGNEKD+DEA+TVGCCTLKV+NVT   PNK
Sbjct: 614 DTYTKDFRSKDKTKKQIAVATYLIDKLALRAGNEKDEDEAETVGCCTLKVDNVTCVPPNK 673

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           L+F+FLGKDSI+Y NTVEVEL VY AI +F+  KK G DLFD LDT++LNAHLK+LMPGL
Sbjct: 674 LQFDFLGKDSIRYFNTVEVELLVYKAIEEFRAGKKPGQDLFDKLDTTRLNAHLKDLMPGL 733

Query: 716 TAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMT 775
           TAKVFRT+NASITLDD+L+K+T+DG + EKI VYQ ANK+VAIICNHQRSVSKSHD+QMT
Sbjct: 734 TAKVFRTYNASITLDDILHKETEDGTLLEKIAVYQRANKEVAIICNHQRSVSKSHDSQMT 793

Query: 776 RLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKM 835
           RLNEK+DEL+A   EL+ DL + R               NL+ EA EKKISQ   KIEKM
Sbjct: 794 RLNEKIDELKAQRDELKADLSKVRKGKNLGNDKDGKPKRNLAPEAFEKKISQIETKIEKM 853

Query: 836 QRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           + D K KEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK+F
Sbjct: 854 EMDKKIKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKLF 896


>A9T3W2_PHYPA (tr|A9T3W2) Predicted protein OS=Physcomitrella patens subsp.
           patens GN=PHYPADRAFT_139910 PE=3 SV=1
          Length = 632

 Score =  771 bits (1991), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 378/552 (68%), Positives = 431/552 (78%), Gaps = 2/552 (0%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYM 406
           P SGDG K WTTL HNGVIFPPPY+PH VKMLY GKPVDLT  QEE+ATM+AVM +TDY 
Sbjct: 83  PVSGDGVK-WTTLEHNGVIFPPPYEPHGVKMLYDGKPVDLTPAQEEIATMFAVMLETDYA 141

Query: 407 LKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
            K++F +NFW+DW+  LGKNHVI+  + CDFTPI+DW                       
Sbjct: 142 KKERFIKNFWDDWKPYLGKNHVIKKFELCDFTPIFDWHAREKERKKSMSTEEKKRLKEEK 201

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   WA+VDGVKEKVGNFRVEPPGLFRGRG+HPKMGKLK RI P DIVINIGKDA 
Sbjct: 202 LAVEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKMGKLKTRILPHDIVINIGKDAA 261

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           +PECPIPG+RWKEIRHDNTVTWLA+W DPIN K FKYVFLAASSSLKGQSD +KYEKARM
Sbjct: 262 VPECPIPGQRWKEIRHDNTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMQKYEKARM 321

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LKDYI +IR  YT DF+S D TKQQIAVATYLID+LALRAGNEKD+DEADTVGCC+LKVE
Sbjct: 322 LKDYIDDIRRTYTHDFSSSDPTKQQIAVATYLIDRLALRAGNEKDEDEADTVGCCSLKVE 381

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNA 706
           +VT  AP  L+F+FLGKDSI+Y NTVEV+  VY AI +F+K KK GDDLF+ LDT+KLN 
Sbjct: 382 HVTLVAPKSLQFDFLGKDSIRYFNTVEVDERVYKAIGQFKKGKKEGDDLFERLDTTKLNL 441

Query: 707 HLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSV 766
           HLK +MP LTAKVFRT+NASITLD++L   T +  + E I  YQ ANKQVAI+CNHQRSV
Sbjct: 442 HLKGIMPSLTAKVFRTYNASITLDNLLQDTTGETTI-EIIADYQRANKQVAILCNHQRSV 500

Query: 767 SKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKIS 826
           SK H  QM RL  K+ EL+  L+EL TDLDRA+               N + EALEKKI+
Sbjct: 501 SKGHSAQMERLEGKMQELEEQLEELETDLDRAKKGKPPLKDSEGKVKRNQTPEALEKKIA 560

Query: 827 QTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
            T  KI+KM+ DM+ K+DLKTVALGTSKINY+DPRITVAWCKRHEVPIEKIFNKSLL+KF
Sbjct: 561 ATKQKIDKMRLDMRVKDDLKTVALGTSKINYMDPRITVAWCKRHEVPIEKIFNKSLLSKF 620

Query: 887 TWAMDVDPDFRF 898
            WAM+V+PDFRF
Sbjct: 621 AWAMEVEPDFRF 632


>Q8RX06_ARATH (tr|Q8RX06) Putative DNA topoisomerase I (Fragment) OS=Arabidopsis
           thaliana GN=At5g55300 PE=2 SV=1
          Length = 514

 Score =  749 bits (1935), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 359/510 (70%), Positives = 408/510 (80%)

Query: 389 DQEEVATMYAVMRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXX 448
           +QEEVATM+AVMR+TDY  K +F+ENFWNDWR+LLGK HVIQ L DCDFTPIY+W     
Sbjct: 2   EQEEVATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKHVIQKLDDCDFTPIYEWHLEEK 61

Query: 449 XXXXXXXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKL 508
                                     WA+VDGVKEK+GNFRVEPPGLFRGRGEHPKMGKL
Sbjct: 62  EKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPKMGKL 121

Query: 509 KRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAA 568
           K+RI P +I +NIGK APIPECPI GERWKE++HDNTVTWLAFW DPINPK FKYVFL A
Sbjct: 122 KKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGA 181

Query: 569 SSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGN 628
            SSLKG SDKEKYEKAR L D+I NIR  YTK+FT+KD+  +QIAVATYLIDKLALRAGN
Sbjct: 182 GSSLKGLSDKEKYEKARNLTDHIDNIRTTYTKNFTAKDVKMRQIAVATYLIDKLALRAGN 241

Query: 629 EKDDDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD 688
           EKDDDEADTVGCCTLKV NV    PNK+KF+FLGKDSI+Y NTVEVE  VY AI +FQ  
Sbjct: 242 EKDDDEADTVGCCTLKVGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAG 301

Query: 689 KKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVV 748
           K   DDLFD LDTSKLNAHLKEL+PGLTAKVFRT+NASITLD+ML+++TKDGDV +KIVV
Sbjct: 302 KSKTDDLFDELDTSKLNAHLKELVPGLTAKVFRTYNASITLDEMLSQETKDGDVTQKIVV 361

Query: 749 YQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXX 808
           YQ ANK+VAIICNHQR+VSK+H  Q+ +L  +++EL+ VLKEL+T+LDRA+         
Sbjct: 362 YQKANKEVAIICNHQRTVSKTHGAQIEKLTARIEELKEVLKELKTNLDRAKKGKPPLEGS 421

Query: 809 XXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCK 868
                 +L   A EKKI+Q +AKIEKM+RDM TKEDLKTVALGTSKINYLDPRITVAWCK
Sbjct: 422 DGKKIRSLEPNAWEKKIAQQSAKIEKMERDMHTKEDLKTVALGTSKINYLDPRITVAWCK 481

Query: 869 RHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           RHEVPIEKIF KSLL KF WAMDV+P++RF
Sbjct: 482 RHEVPIEKIFTKSLLEKFAWAMDVEPEYRF 511


>A9T368_PHYPA (tr|A9T368) Predicted protein OS=Physcomitrella patens subsp.
           patens GN=PHYPADRAFT_107400 PE=3 SV=1
          Length = 502

 Score =  674 bits (1740), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 339/503 (67%), Positives = 391/503 (77%), Gaps = 1/503 (0%)

Query: 396 MYAVMRDTDYMLKDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXX 455
           M+AVM +TDY  K++F +NFW+DW+  LGKNHVI+  + CDFTPI+ W            
Sbjct: 1   MFAVMIETDYAKKERFVKNFWDDWKPYLGKNHVIKKFELCDFTPIFQWHAREKERKKNMS 60

Query: 456 XXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPS 515
                              WA+VDGVKEKVGNFRVEPPGLFRGRG+HPKMGKLK RI P 
Sbjct: 61  AEEKKRLKEEKLAAEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKMGKLKTRILPH 120

Query: 516 DIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQ 575
           DIVINIGKDAP+PECPIPG++WKE+RHDNTVTWLA+W DPIN K FKYVFLAASSSLKGQ
Sbjct: 121 DIVINIGKDAPVPECPIPGQKWKEVRHDNTVTWLAYWKDPINDKEFKYVFLAASSSLKGQ 180

Query: 576 SDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEA 635
           SD  KYEKAR LKDYI NIR  YTKDF+S D TKQQIAVATYLID+LALRAGNEKD+DEA
Sbjct: 181 SDMLKYEKARTLKDYIDNIRRTYTKDFSSSDPTKQQIAVATYLIDRLALRAGNEKDEDEA 240

Query: 636 DTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDL 695
           DTVGCC+LKVE+V+  AP  L+F+FLGKDSI+Y NTVEV+  VY AI +F+K KKGGDDL
Sbjct: 241 DTVGCCSLKVEHVSLIAPKSLQFDFLGKDSIRYFNTVEVDERVYKAIGQFKKGKKGGDDL 300

Query: 696 FDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQ 755
           F+ LDT+KLN HLK +MPGLTAKVFRT+NASITLD +L +DT+     E I  YQ ANK+
Sbjct: 301 FERLDTTKLNLHLKGIMPGLTAKVFRTYNASITLDTLL-QDTRGETTIEIIADYQRANKE 359

Query: 756 VAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXN 815
           VAI+CNHQRSVSK H  QM RL  K+ EL+  L+EL TDLDRA+               N
Sbjct: 360 VAILCNHQRSVSKGHSAQMERLELKMQELEEQLEELETDLDRAKRGKPPLKDSEGKVKRN 419

Query: 816 LSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIE 875
            + EALEKKI+ T  KI+KM+ DM+ K+DLKTVALGTSKINY+DPRITVAWCKRHEVPIE
Sbjct: 420 QTPEALEKKIASTTQKIDKMRLDMRVKDDLKTVALGTSKINYMDPRITVAWCKRHEVPIE 479

Query: 876 KIFNKSLLAKFTWAMDVDPDFRF 898
           KIFNKSLL+KF WAM+V+PDFRF
Sbjct: 480 KIFNKSLLSKFAWAMEVEPDFRF 502


>A8IDM1_CHLRE (tr|A8IDM1) DNA topoisomerase I (Fragment) OS=Chlamydomonas
           reinhardtii GN=TOP1 PE=3 SV=1
          Length = 586

 Score =  623 bits (1607), Expect = e-176,   Method: Compositional matrix adjust.
 Identities = 316/564 (56%), Positives = 384/564 (68%), Gaps = 13/564 (2%)

Query: 348 SSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYML 407
           SS  GQ  W TL H GV+FPP Y+PH VK LY GKPVDLT DQEEVATM+AVM++TDYM 
Sbjct: 23  SSKSGQVMWKTLKHAGVLFPPEYEPHGVKPLYDGKPVDLTPDQEEVATMFAVMKETDYMN 82

Query: 408 KDKFKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXX 467
           K  F +NFW  ++++LGK HVI++LK CDFTPIYDW                        
Sbjct: 83  KKVFLDNFWEGFKEVLGKGHVIKDLKKCDFTPIYDWHMAQREAKKGISKEEKDRIKKEKD 142

Query: 468 XXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPI 527
                   A VDG  E VGNFRVEPPGLFRGRGEHPKMGK+K+R+ P DI INIG++ P+
Sbjct: 143 EKEAKYKVAYVDGRPEPVGNFRVEPPGLFRGRGEHPKMGKIKKRVYPRDITINIGENEPV 202

Query: 528 PECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARML 587
           PE P PG+ WKE++HD+TVTWLA+W D I+ K +KYVFL A+S+ K  SD  KYEKAR L
Sbjct: 203 PEHPYPGQTWKEVKHDHTVTWLAYWKDTISTKDYKYVFLGATSTFKADSDLAKYEKARKL 262

Query: 588 KDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVEN 647
           K+ I ++R  Y +D+ S D  K+Q+ VA Y IDKLALRAG+EKD+DEADTVGCCTLKVEN
Sbjct: 263 KEIIVDVRKNYERDWDSSDQRKRQMGVAMYFIDKLALRAGHEKDEDEADTVGCCTLKVEN 322

Query: 648 VTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQ------KDKKGGDDLFDMLDT 701
           +     NK+KF+FLGKDSI+YEN VEV+  VY  + KF+      K K+ GD LF+  D 
Sbjct: 323 IEIMGDNKVKFDFLGKDSIRYENIVEVDPRVYKNLEKFKRIDHTGKRKQQGDQLFETFDA 382

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLN--KDTKDGD-----VGEKIVVYQHANK 754
             LN  LK +M GL+ KVFRT+NASI LD +L+  + TK G      V +K V Y  ANK
Sbjct: 383 QDLNKELKNIMDGLSVKVFRTYNASIVLDRLLSEWEATKKGHSTAQTVDQKKVDYDIANK 442

Query: 755 QVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXX 814
           +VAI+CNHQRSV K+H  QM ++ EKL  +   L EL  +L  A+               
Sbjct: 443 EVAILCNHQRSVPKTHTNQMEKIQEKLAGMNKELAELEDELRAAQKGKAENKKANKCGAP 502

Query: 815 NLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPI 874
            +   AL  KI +    I K++   ++KEDLKTVALGTSKINY+DPRITVAWCKR+EVPI
Sbjct: 503 TILPWALNSKIDKKKQAIAKVELQARSKEDLKTVALGTSKINYMDPRITVAWCKRNEVPI 562

Query: 875 EKIFNKSLLAKFTWAMDVDPDFRF 898
           EKIFNKSLLAKF WAMDVDP FRF
Sbjct: 563 EKIFNKSLLAKFNWAMDVDPTFRF 586


>Q56XA9_ARATH (tr|Q56XA9) DNA topoisomerase I (Fragment) OS=Arabidopsis thaliana
           GN=At5g55300 PE=2 SV=1
          Length = 396

 Score =  593 bits (1529), Expect = e-167,   Method: Compositional matrix adjust.
 Identities = 287/393 (73%), Positives = 328/393 (83%)

Query: 506 GKLKRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVF 565
           G+LK+RI P +I +NIGK APIPECPI GERWKE++HDNTVTWLAFW DPINPK FKYVF
Sbjct: 1   GELKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVF 60

Query: 566 LAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALR 625
           L A SSLKG SDKEKYEKAR L D+I NIR  YTK+FT+KD+  +QIAVATYLIDKLALR
Sbjct: 61  LGAGSSLKGLSDKEKYEKARNLTDHIDNIRTTYTKNFTAKDVKMRQIAVATYLIDKLALR 120

Query: 626 AGNEKDDDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKF 685
           AGNEKDDDEADTVGCCTLKV NV    PNK+KF+FLGKDSI+Y NTVEVE  VY AI +F
Sbjct: 121 AGNEKDDDEADTVGCCTLKVGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQF 180

Query: 686 QKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEK 745
           Q  K   DDLFD LDTSKLNAHLKEL+PGLTAKVFRT+NASITLD+ML+++TKDGDV +K
Sbjct: 181 QAGKSKTDDLFDELDTSKLNAHLKELVPGLTAKVFRTYNASITLDEMLSQETKDGDVTQK 240

Query: 746 IVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXX 805
           IVVYQ ANK+VAIICNHQR+VSK+H  Q+ +L  +++EL+ VLKEL+T+LDRA+      
Sbjct: 241 IVVYQKANKEVAIICNHQRTVSKTHGAQIEKLTARIEELKEVLKELKTNLDRAKKGKPPL 300

Query: 806 XXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVA 865
                    +L   A EKKI+Q +AKIEKM+RDM TKEDLKTVALGTSKINYLDPRITVA
Sbjct: 301 EGSDGKKIRSLEPNAWEKKIAQQSAKIEKMERDMHTKEDLKTVALGTSKINYLDPRITVA 360

Query: 866 WCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           WCKRHEVPIEKIF KSLL KF WAMDV+P++RF
Sbjct: 361 WCKRHEVPIEKIFTKSLLEKFAWAMDVEPEYRF 393


>Q00XV7_OSTTA (tr|Q00XV7) Putative DNA topoisomerase I (ISS) OS=Ostreococcus
           tauri GN=Ot12g02020 PE=3 SV=1
          Length = 783

 Score =  516 bits (1330), Expect = e-144,   Method: Compositional matrix adjust.
 Identities = 260/545 (47%), Positives = 348/545 (63%), Gaps = 24/545 (4%)

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           W TL HNGV+FPPPY+PH V + Y G+ V L   +EE+A  +AVM+DTDY  K  F +NF
Sbjct: 237 WKTLEHNGVVFPPPYEPHGVPLTYDGQDVKLLPHEEEIAGFFAVMKDTDYAQKAVFVKNF 296

Query: 416 WNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 473
            + +++ L  G +  I + + CDFT +Y+                               
Sbjct: 297 MDGFKEALANGPHAFITDFRKCDFTKMYNHFAKIREEKKQMTSEEKKRIKAEKDKAEEMY 356

Query: 474 XWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIP 533
            WA +DG +EKVGNFR+EPPGLFRGRGEHPKMGK+KRR+ P DI INIGKDA +P  P P
Sbjct: 357 TWATIDGRREKVGNFRIEPPGLFRGRGEHPKMGKIKRRVMPEDITINIGKDARVPPPP-P 415

Query: 534 GERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGN 593
           G  WK + H++T TWLA WND IN K +KYV   A+S++K +SD++KYEKAR L  +I  
Sbjct: 416 GHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYEKARSLHKFIEK 475

Query: 594 IRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAP 653
           IRA Y ++  S+     Q+AV TYL+DKLALRAG EKD+D ADTVG CTL+  ++     
Sbjct: 476 IRADYKRNMQSESREMAQLAVTTYLVDKLALRAGGEKDEDLADTVGVCTLRAGHIKFMED 535

Query: 654 NKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMP 713
           N ++F+FLGKDSI+Y    +++   Y  + +F KDK    D+FD++D SK+NAHL+ LMP
Sbjct: 536 NVIEFDFLGKDSIQYLQQHKIDEVAYKCLQRFVKDKGPDVDIFDLIDPSKVNAHLQTLMP 595

Query: 714 GLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQ 773
           GLT KVFRT+NASITLD +L     +    +K   Y  ANK+VAI+CNHQ+ VSK+HD Q
Sbjct: 596 GLTIKVFRTYNASITLDSLLADTDTNLTTLQKKAKYDAANKEVAILCNHQKGVSKAHDEQ 655

Query: 774 MTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIE 833
           M +LN+K  +L   + +++                      N   +  +KK++    +  
Sbjct: 656 MGKLNDKKKDLAKQITDMKK---------------------NKDDKNQKKKLTALKERAA 694

Query: 834 KMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVD 893
           K+   M+ KE+LKTV+LGTSKINYLDPRIT++WCKRHEVP   +F K+L+ KF WAMD D
Sbjct: 695 KLAIQMEMKEELKTVSLGTSKINYLDPRITLSWCKRHEVPPPTVFTKALIDKFHWAMDCD 754

Query: 894 PDFRF 898
            DF+F
Sbjct: 755 MDFKF 759


>B4L533_DROMO (tr|B4L533) GI21653 OS=Drosophila mojavensis GN=GI21653 PE=4 SV=1
          Length = 1043

 Score =  504 bits (1299), Expect = e-141,   Method: Compositional matrix adjust.
 Identities = 264/562 (46%), Positives = 357/562 (63%), Gaps = 32/562 (5%)

Query: 355  KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
            KWTTL H G +F PPY+  P  V+  Y GKP++L+ + EE AT YA M + DY  KD F 
Sbjct: 496  KWTTLEHKGPVFAPPYERVPRNVRFFYDGKPMELSEETEEAATFYAKMLNHDYCTKDVFN 555

Query: 413  ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
             NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 556  NNFFKDFRKTMTPKEKEIIKDFRKCNFQEMFEYFQAESEKRKAATKEEKLAKKVESEALI 615

Query: 471  XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI   D+ IN GK++ +P+ 
Sbjct: 616  KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAARDVSINCGKNSKVPQ- 674

Query: 531  PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
            P PGERWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L  +
Sbjct: 675  PPPGERWKEVRHDNTVTWLASWTENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKF 733

Query: 591  IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVT- 649
            I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 734  IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 793

Query: 650  -REAPNK---LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
             +E  NK   + F+F GKDSI+Y N VEVE  V+  +  F ++KK GDDLFD L+T  LN
Sbjct: 794  HKELNNKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKDGDDLFDRLNTQVLN 853

Query: 706  AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
             HLKELM GLTAKVFRT+NAS TL + L+  T  +  V EK++ Y  AN+ VAI+CNHQR
Sbjct: 854  EHLKELMEGLTAKVFRTYNASKTLQNQLDLLTDPNASVAEKLLTYNRANRAVAILCNHQR 913

Query: 765  SVSKSHDTQMTRLNEK-------LDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLS 817
            SV K H   M  L EK       LDE ++   +LR    R                  L+
Sbjct: 914  SVPKGHQKSMENLKEKIRAKRDALDECESEYHDLRKAAKRG------------SVKEKLN 961

Query: 818  SEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKI 877
            ++   K++ +   +++K++     +++ KT+ALGTSK+NYLDPRITVAWCK++ VPIEKI
Sbjct: 962  ADKKGKQLERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRITVAWCKKYGVPIEKI 1021

Query: 878  FNKSLLAKFTWAMDV-DPDFRF 898
            FNK+   KF WA+ + D ++RF
Sbjct: 1022 FNKTHRTKFLWAIHMADENYRF 1043


>B4NCJ2_DROWI (tr|B4NCJ2) GK25865 OS=Drosophila willistoni GN=GK25865 PE=4 SV=1
          Length = 997

 Score =  498 bits (1283), Expect = e-139,   Method: Compositional matrix adjust.
 Identities = 263/559 (47%), Positives = 357/559 (63%), Gaps = 26/559 (4%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F PPY+  P  V+  Y GKP+DLT + EE AT YA M + DY  KD F 
Sbjct: 450 KWSTLEHKGPVFAPPYERVPRNVRFFYDGKPLDLTEETEEAATFYAKMLNHDYCTKDVFN 509

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 510 TNFFKDFRKTMTDREKEIIKDFRKCNFQEMFEFFQAESERRKAATKDEKLAKKNENEALV 569

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI  S++ IN GK++ +P  
Sbjct: 570 KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASEVSINCGKNSKVP-T 628

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG+RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 629 PPPGQRWKEVRHDNTVTWLASWVENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 687

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVT- 649
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 688 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 747

Query: 650 -RE---APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
            RE     N + F+F GKDSI+Y N VEVE  V+  +  F ++KK GDDLFD L+T  LN
Sbjct: 748 HRELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKEGDDLFDRLNTQVLN 807

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD--VGEKIVVYQHANKQVAIICNHQ 763
            HLKELM GLTAKVFRT+NAS TL D L+K T DGD  V EK++ Y  AN+ VAI+CNHQ
Sbjct: 808 EHLKELMDGLTAKVFRTYNASKTLQDQLDKLT-DGDATVAEKLLAYNRANRAVAILCNHQ 866

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRT---DLDRARXXXXXXXXXXXXXXXNLSSEA 820
           RSV K H   M  L EK+   +  + +  +   DL +A                 ++++ 
Sbjct: 867 RSVPKGHQKSMENLKEKIRAKRDAIDDCESEYHDLKKA--------AKRGSVKEKVNADK 918

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
             K++ +   +++K++     +++ KT+AL TSK+NYLDPRI+VAWCK++ VPIEKIFNK
Sbjct: 919 KGKQLERLKEQLKKLELQETDRDENKTIALSTSKLNYLDPRISVAWCKKNGVPIEKIFNK 978

Query: 881 SLLAKFTWAMDV-DPDFRF 898
           +   KF WA+ + D ++RF
Sbjct: 979 TQRTKFLWAIHMADENYRF 997


>B4M707_DROVI (tr|B4M707) GJ16891 OS=Drosophila virilis GN=GJ16891 PE=4 SV=1
          Length = 1045

 Score =  493 bits (1269), Expect = e-137,   Method: Compositional matrix adjust.
 Identities = 259/562 (46%), Positives = 351/562 (62%), Gaps = 32/562 (5%)

Query: 355  KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
            KWTTL H G +F PPY+  P  V+  Y GKP++L+ + EE AT YA M + DY  KD F 
Sbjct: 498  KWTTLEHKGPVFAPPYERMPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKDVFN 557

Query: 413  ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
             NF+ D+RK +   +  +I++ + C+F  ++ +                           
Sbjct: 558  NNFFKDFRKSMTPKEKEIIKDFRKCNFQEMHQFFLAESEKRKAATKEEKLAKKNENEALI 617

Query: 471  XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI  +D+ IN GK + +P+ 
Sbjct: 618  KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAAADVSINCGKQSKVPQ- 676

Query: 531  PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
            P PGERWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L  +
Sbjct: 677  PPPGERWKEVRHDNTVTWLASWTENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKF 735

Query: 591  IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
            I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 736  IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 795

Query: 651  E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                    N + F+F GKDSI+Y N VEVE  V+  +  F ++KK GDDLFD L+T  LN
Sbjct: 796  HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKDGDDLFDRLNTQVLN 855

Query: 706  AHLKELMPGLTAKVFRTFNASITLDDMLNKDT-KDGDVGEKIVVYQHANKQVAIICNHQR 764
             HLKELM GLTAKVFRT+NAS TL + L+  T  +  V EK++ Y  AN+ VAI+CNHQR
Sbjct: 856  EHLKELMDGLTAKVFRTYNASKTLQNQLDLLTDSNASVAEKLLTYNRANRAVAILCNHQR 915

Query: 765  SVSKSHDTQMTRLNEK-------LDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLS 817
            SV K H   M  L EK       +D+ +A   +L+    R                  + 
Sbjct: 916  SVPKGHQKSMENLKEKIRAKRDAIDDCEAEYHDLKKAAKRG------------SVKERVI 963

Query: 818  SEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKI 877
            ++   K + +   +++K++     +++ KT+ALGTSK+NYLDPRITVAWCK++ VPIEKI
Sbjct: 964  ADKKGKILERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRITVAWCKKYGVPIEKI 1023

Query: 878  FNKSLLAKFTWAMDV-DPDFRF 898
            FNK+   KF WA+ + D ++RF
Sbjct: 1024 FNKTHRTKFLWAIHMADENYRF 1045


>Q494M1_DROME (tr|Q494M1) RE58921p (CG6146-PC, isoform C) OS=Drosophila
           melanogaster GN=Top1 PE=2 SV=1
          Length = 974

 Score =  491 bits (1265), Expect = e-137,   Method: Compositional matrix adjust.
 Identities = 255/555 (45%), Positives = 348/555 (62%), Gaps = 32/555 (5%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F P Y+  P  V+  Y GKP++L+ + EE AT YA M + DY  K+ F 
Sbjct: 441 KWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFN 500

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 501 NNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALM 560

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI+ SD+ IN GKD+ +P  
Sbjct: 561 KEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVP-S 619

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 620 PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 678

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 679 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 738

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 739 HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLN 798

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 799 EHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQR 858

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           SV KSH+  M  L EK+   +  +++  ++                    +   E   K+
Sbjct: 859 SVPKSHEKSMENLKEKIKAKREAIEKCESEY-------------------HSRDEKKGKQ 899

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+H+VPIEKIFNK+   
Sbjct: 900 LERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRT 959

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+ + D ++RF
Sbjct: 960 KFLWAVHMADENYRF 974


>Q17HT9_AEDAE (tr|Q17HT9) DNA topoisomerase type I OS=Aedes aegypti GN=AAEL002551
           PE=3 SV=1
          Length = 966

 Score =  489 bits (1260), Expect = e-136,   Method: Compositional matrix adjust.
 Identities = 255/555 (45%), Positives = 348/555 (62%), Gaps = 22/555 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL H G +F PPY+P    VK  Y GK + L+ D EE+A  YA M + +Y  KD F 
Sbjct: 423 KWNTLEHKGPVFAPPYEPLPDNVKFEYDGKVIKLSQDAEEIAGFYARMLEHEYTSKDAFN 482

Query: 413 ENFWNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +   +   I++LK C+F  ++                             
Sbjct: 483 DNFFKDWRKSMTSSEREKIKDLKKCNFRSMHKHFAEISEANRNRTKEQKLALKEQNEALM 542

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                  +DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRR+ P D++IN GK++  P+ 
Sbjct: 543 KEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMVKRRVMPEDVIINCGKESVWPKA 602

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G RWKE+RHDN+V+WLA W + +  ++ KYV L  SS LKG+ D +KYE AR L  +
Sbjct: 603 P-EGHRWKEVRHDNSVSWLASWTENVQGQV-KYVMLNPSSKLKGEKDWQKYETARRLLKH 660

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IR  Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE++  
Sbjct: 661 IDKIRDTYRDEWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIDL 720

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+FLGKDSI+Y N VEVE  V+  +  F+++KK GDDLFD L+TS LN
Sbjct: 721 HKELNGKENVVVFDFLGKDSIRYYNEVEVEKRVFKNLELFKENKKPGDDLFDRLNTSVLN 780

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HL+ELM GLTAKVFRTFNAS TL + L + T  D  V EK++ Y  AN+ VAI+CNHQR
Sbjct: 781 EHLRELMEGLTAKVFRTFNASFTLQNQLRELTDPDMTVPEKLLAYNRANRAVAILCNHQR 840

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           +V K+H+  M+ L EK+   Q  ++    +L                    ++ +  +K+
Sbjct: 841 AVPKTHEKSMSNLKEKIRAKQEAVETCEREL---------KDLKKSNVRDKVAKDKKQKQ 891

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   ++ K++     K++ KT+ALGTSK+NYLDPRI+VAWCK+  VPIEKIFNK+   
Sbjct: 892 LERLREQLNKLELQETDKDENKTIALGTSKLNYLDPRISVAWCKKFGVPIEKIFNKTQRD 951

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+D+ D ++ F
Sbjct: 952 KFRWAIDMADENYIF 966


>B3MR83_DROAN (tr|B3MR83) GF21232 OS=Drosophila ananassae GN=GF21232 PE=4 SV=1
          Length = 990

 Score =  489 bits (1259), Expect = e-136,   Method: Compositional matrix adjust.
 Identities = 254/555 (45%), Positives = 347/555 (62%), Gaps = 32/555 (5%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F PPY+  P  V+  Y GKP++L+ + EE AT YA M + DY  KD F 
Sbjct: 457 KWSTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKDVFN 516

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 517 TNFFKDFRKSMTSKEKEIIKDFRKCNFQEMHNYFQAESEKRKAATKEEKLAKKNENEALV 576

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI+ SD+ IN GK++ +P  
Sbjct: 577 KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESHVP-S 635

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG+RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 636 PPPGQRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 694

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 695 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 754

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 755 HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKDGDDLFDRLNTQVLN 814

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 815 EHLKELMDGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQR 874

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           SV K H   M  L EK+   +  + +   +                    ++ ++   K+
Sbjct: 875 SVPKGHQKSMENLKEKIKAKRDAIDDCEAEY-------------------HVLADKKGKQ 915

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+H VPIEKIFNK+   
Sbjct: 916 LERLKEQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIFNKTQRT 975

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+ + D ++RF
Sbjct: 976 KFLWAVHMADENYRF 990


>B4ILF9_DROSE (tr|B4ILF9) GM19769 OS=Drosophila sechellia GN=GM19769 PE=4 SV=1
          Length = 970

 Score =  488 bits (1257), Expect = e-136,   Method: Compositional matrix adjust.
 Identities = 255/555 (45%), Positives = 346/555 (62%), Gaps = 32/555 (5%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F P Y+  P  V+  Y GKP++L+ + EE AT YA M + DY  K+ F 
Sbjct: 437 KWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFN 496

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C F  ++++                           
Sbjct: 497 NNFFKDFRKSMTPREREIIKDFRKCGFQEMFNYFQAESEKRKAASKEEKLIKKNENEALM 556

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI  SD+ IN GKD+ +P  
Sbjct: 557 KEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIHASDVSINCGKDSKVP-S 615

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 616 PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 674

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 675 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 734

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 735 HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLN 794

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 795 EHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQR 854

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           SV KSH+  M  L EK+   +  +++  ++                    N   E   K+
Sbjct: 855 SVPKSHEKSMENLKEKIKAKREAIEKCESEY-------------------NSRDEKKGKQ 895

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+++VPIEKIFNK+   
Sbjct: 896 LDRLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKNDVPIEKIFNKTQRT 955

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+ + D ++RF
Sbjct: 956 KFLWAVHMADENYRF 970


>B3NTM5_DROER (tr|B3NTM5) GG17874 OS=Drosophila erecta GN=GG17874 PE=4 SV=1
          Length = 969

 Score =  488 bits (1255), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 255/555 (45%), Positives = 346/555 (62%), Gaps = 32/555 (5%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F P Y+  P  V+  Y GKP++L+ + EE AT YA M + DY  K+ F 
Sbjct: 436 KWSTLEHKGPVFAPRYERVPRNVRFYYDGKPMELSEETEEAATFYAKMLNHDYCTKEVFN 495

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C F  ++++                           
Sbjct: 496 NNFFKDFRKSMTSKEREIIKDFRKCGFNEMFNFFQAESEKRKAATKEEKLIKKNENEALM 555

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI+ SD+ IN GK++ +P  
Sbjct: 556 KEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESKVP-S 614

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 615 PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 673

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 674 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 733

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 734 HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKDGDDLFDRLNTQVLN 793

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 794 EHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQR 853

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           SV KSH+  M  L EK+   +  +K+   +                    +   E   K+
Sbjct: 854 SVPKSHEKSMENLKEKIKAKREAIKKCEAEY-------------------HSRDEKKGKQ 894

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+H+VPIEKIFNK+   
Sbjct: 895 LERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRT 954

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+ + D ++RF
Sbjct: 955 KFLWAVHMADENYRF 969


>Q8IR39_DROME (tr|Q8IR39) CG6146-PB, isoform B OS=Drosophila melanogaster GN=Top1
           PE=2 SV=1
          Length = 581

 Score =  487 bits (1254), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 255/555 (45%), Positives = 348/555 (62%), Gaps = 32/555 (5%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F P Y+  P  V+  Y GKP++L+ + EE AT YA M + DY  K+ F 
Sbjct: 48  KWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFN 107

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 108 NNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALM 167

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI+ SD+ IN GKD+ +P  
Sbjct: 168 KEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVP-S 226

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 227 PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 285

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 286 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 345

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 346 HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLN 405

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 406 EHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQR 465

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           SV KSH+  M  L EK+   +  +++  ++                    +   E   K+
Sbjct: 466 SVPKSHEKSMENLKEKIKAKREAIEKCESEY-------------------HSRDEKKGKQ 506

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+H+VPIEKIFNK+   
Sbjct: 507 LERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRT 566

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+ + D ++RF
Sbjct: 567 KFLWAVHMADENYRF 581


>B4GVZ4_DROPE (tr|B4GVZ4) GL14571 OS=Drosophila persimilis GN=GL14571 PE=4 SV=1
          Length = 1042

 Score =  486 bits (1252), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 256/558 (45%), Positives = 351/558 (62%), Gaps = 24/558 (4%)

Query: 355  KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
            KW+TL H G +F PPY+  P  V+  Y G+P+DL+ + EE AT YA M + DY  KD F 
Sbjct: 495  KWSTLEHKGPVFAPPYERVPRNVRFFYDGRPLDLSEETEEAATFYAKMLNHDYCTKDIFN 554

Query: 413  ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
             NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 555  NNFFKDFRKSMTSKEKEIIKDFRKCNFQEMHEYFQAESEKRKQATKEEKLAKKNENEALI 614

Query: 471  XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI  SD+ IN GK++ +P  
Sbjct: 615  KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASDVSINCGKESKVPP- 673

Query: 531  PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
            P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 674  PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKS 732

Query: 591  IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVT- 649
            I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 733  IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 792

Query: 650  ----REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                 +  N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 793  HKELNDKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLN 852

Query: 706  AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
             HLKELM GLTAKVFRT+NAS TL + L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 853  EHLKELMDGLTAKVFRTYNASKTLQNQLDLLTDPSATVPEKLLTYNRANRAVAILCNHQR 912

Query: 765  SVSKSHDTQMTRLNEKLDELQAVLKELRT---DLDRARXXXXXXXXXXXXXXXNLSSEAL 821
            SV K H   M  L EK+   +  + +  +   DL +A                 ++++  
Sbjct: 913  SVPKGHQKSMENLKEKIRAKRDAIDDCESEYHDLKKA--------AKRGSVKEKVNADKK 964

Query: 822  EKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKS 881
             K++ +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK++ VPIEKIFNK+
Sbjct: 965  GKQLERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKNGVPIEKIFNKT 1024

Query: 882  LLAKFTWAMDV-DPDFRF 898
               KF WA+ + D ++RF
Sbjct: 1025 QRTKFLWAVHMADENYRF 1042


>B4JLU3_DROGR (tr|B4JLU3) GH24453 OS=Drosophila grimshawi GN=GH24453 PE=4 SV=1
          Length = 1063

 Score =  486 bits (1252), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 257/563 (45%), Positives = 350/563 (62%), Gaps = 34/563 (6%)

Query: 355  KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
            KWTTL H G +F PPY+  P  V+  Y GKP++L+ + EE AT YA M + DY  KD F 
Sbjct: 516  KWTTLEHKGPVFAPPYERVPQNVRFFYDGKPLELSEETEEAATFYAKMLNHDYCTKDVFN 575

Query: 413  ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
             NF+ D+RK +   +  +I++ + C+F  ++ +                           
Sbjct: 576  TNFFKDFRKTMTVKEKEIIKDFRKCNFQEMFQFFQAESEKRKAATKEEKLLKKNENEALV 635

Query: 471  XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI  +D+ IN GK + +P+ 
Sbjct: 636  KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAAADVSINCGKQSKVPQP 695

Query: 531  PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
            P+ G RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 696  PMGG-RWKEVRHDNTVTWLASWTENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 753

Query: 591  IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
            I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 754  IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 813

Query: 651  E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                    N + F+F GKDSI+Y N VEVE  V+  +  F ++KK GDDLFD L+T  LN
Sbjct: 814  HKELNCKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKEGDDLFDRLNTQVLN 873

Query: 706  AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD--VGEKIVVYQHANKQVAIICNHQ 763
             HLKELM GLTAKVFRT+NAS TL   L+  T DG   V EK++ Y  AN+ VAI+CNHQ
Sbjct: 874  EHLKELMEGLTAKVFRTYNASKTLQSQLDLLT-DGSATVAEKLLAYNRANRAVAILCNHQ 932

Query: 764  RSVSKSHDTQMTRLNEK-------LDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNL 816
            RSV K H   M  L EK       +D+ +A   +L+    R                  +
Sbjct: 933  RSVPKGHQKSMDNLKEKIRAKRDNIDDCEAEYHDLKKAAKRG------------SVKEKV 980

Query: 817  SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
            +++   K++ +   +++K++     +++ KT+AL TSK+NYLDPRI+VAWCK++ VPIEK
Sbjct: 981  NADKKAKQLERLKDQLKKLELQETDRDENKTIALSTSKLNYLDPRISVAWCKKNGVPIEK 1040

Query: 877  IFNKSLLAKFTWAMDV-DPDFRF 898
            IFNK+   KF WA+ + D ++RF
Sbjct: 1041 IFNKTQRTKFLWAIHMADENYRF 1063


>B5DMS2_DROPS (tr|B5DMS2) GA24044 OS=Drosophila pseudoobscura pseudoobscura
            GN=Dpse\GA24044 PE=4 SV=1
          Length = 1054

 Score =  486 bits (1251), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 256/558 (45%), Positives = 351/558 (62%), Gaps = 24/558 (4%)

Query: 355  KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
            KW+TL H G +F PPY+  P  V+  Y G+P+DL+ + EE AT YA M + DY  KD F 
Sbjct: 507  KWSTLEHKGPVFAPPYERVPRNVRFFYDGRPLDLSEETEEAATFYAKMLNHDYCTKDIFN 566

Query: 413  ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
             NF+ D+RK +   +  +I++ + C+F  ++++                           
Sbjct: 567  NNFFKDFRKSMTSKEKEIIKDFRKCNFQEMHEYFQAESEKRKQATKEEKLAKKNENEALI 626

Query: 471  XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI  SD+ IN GK++ +P  
Sbjct: 627  KEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASDVSINCGKESKVPP- 685

Query: 531  PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
            P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 686  PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKS 744

Query: 591  IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVT- 649
            I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 745  IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 804

Query: 650  ----REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                 +  N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 805  HKELNDKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLN 864

Query: 706  AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
             HLKELM GLTAKVFRT+NAS TL + L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 865  EHLKELMDGLTAKVFRTYNASKTLQNQLDLLTDPSATVPEKLLTYNRANRAVAILCNHQR 924

Query: 765  SVSKSHDTQMTRLNEKLDELQAVLKELRT---DLDRARXXXXXXXXXXXXXXXNLSSEAL 821
            SV K H   M  L EK+   +  + +  +   DL +A                 ++++  
Sbjct: 925  SVPKGHQKSMENLKEKIRAKRDAIDDCESEYHDLKKA--------AKRGSVKEKVNADKK 976

Query: 822  EKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKS 881
             K++ +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK++ VPIEKIFNK+
Sbjct: 977  GKQLERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKNGVPIEKIFNKT 1036

Query: 882  LLAKFTWAMDV-DPDFRF 898
               KF WA+ + D ++RF
Sbjct: 1037 QRTKFLWAVHMADENYRF 1054


>Q6T721_DANRE (tr|Q6T721) Mitochondrial topoisomerase I OS=Danio rerio GN=top1mt
           PE=2 SV=1
          Length = 600

 Score =  481 bits (1237), Expect = e-133,   Method: Compositional matrix adjust.
 Identities = 259/558 (46%), Positives = 348/558 (62%), Gaps = 23/558 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW++L H G  F P Y+P    +   Y G+ V L+   EE+AT YA M D +Y  K+ F+
Sbjct: 52  KWSSLEHKGPYFAPDYEPLPANICFYYDGQQVKLSPLTEEIATFYAKMLDHEYTTKEVFQ 111

Query: 413 ENFWNDWRKLLGKNH--VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK + K    +I  L  CDFT I+ +                           
Sbjct: 112 KNFFKDWRKEMTKEERKLITTLSKCDFTHIHKYFVEKAEEKKNMTKEEKQVLKDEAARLM 171

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG +EK+GNF++EPPGLFRGRGEHPKMG+LK+RI+P D+ IN  KD+ IPE 
Sbjct: 172 EEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCSKDSKIPE- 230

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +WK ++HDNTVTWLA W + I PK  KY+ L  SS LKG+ D +KYE AR LK+ 
Sbjct: 231 PPAGHKWKRVQHDNTVTWLASWLENI-PKRPKYIMLNPSSKLKGEKDWQKYETARRLKEC 289

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           + +IR  Y +D+ S+++  +Q  VA Y IDKLALRAGNEKDD+ ADTVGCC+L+VE++  
Sbjct: 290 VKSIRKRYMQDWKSREMKSRQRGVAIYFIDKLALRAGNEKDDESADTVGCCSLRVEHIRL 349

Query: 651 EAP-----NKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   + ++F+FLGKDSI+Y N V VE  V+  +  F K K   DDLFD + T  LN
Sbjct: 350 HKHLDGLDHVVEFDFLGKDSIRYYNKVPVEKQVFKNLKLFIKHKDPEDDLFDRISTVNLN 409

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
             L E M GLTAKVFRTFNAS TL D LNK T  D  V EKI+ Y  AN+ VAI+CNHQR
Sbjct: 410 KALTESMSGLTAKVFRTFNASTTLQDQLNKLTSDDCTVEEKILSYNRANRAVAILCNHQR 469

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           +  K+ +  M  L EK+ + +  ++E R +L  A+               + SS+ +EKK
Sbjct: 470 AAPKTFEKSMQLLQEKIQKKKEQIEEARKELKEAK-------QVDKDTPSDKSSKLVEKK 522

Query: 825 ---ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKS 881
              + +   +++K+Q     +E+ K +ALGTSK+NYLDPRITVAWCK+H+VPIEKIFNK+
Sbjct: 523 QKAVQRLCDQLKKLQLQETDREENKVIALGTSKLNYLDPRITVAWCKKHQVPIEKIFNKT 582

Query: 882 LLAKFTWAMDV-DPDFRF 898
              KF WA+D+ D  F+F
Sbjct: 583 HREKFAWAIDMTDESFQF 600


>B4PWL3_DROYA (tr|B4PWL3) GE17178 OS=Drosophila yakuba GN=GE17178 PE=4 SV=1
          Length = 580

 Score =  481 bits (1237), Expect = e-133,   Method: Compositional matrix adjust.
 Identities = 253/555 (45%), Positives = 345/555 (62%), Gaps = 32/555 (5%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW+TL H G +F P Y+  P  V+  Y GKP++L+ + EE AT YA M + DY  K+ F 
Sbjct: 47  KWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFN 106

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+ D+RK +   +  +I++ + C F  ++++                           
Sbjct: 107 NNFFKDFRKSMTSKEREIIKDFRKCGFQEMFNFFQAESEKRKAATKEEKLIKKNENEALM 166

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI+ SD+ IN GK++ +P  
Sbjct: 167 KEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESKVP-S 225

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D  KYE AR L   
Sbjct: 226 PPPGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKDHIKYETARRLDKV 284

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE+V  
Sbjct: 285 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQL 344

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+F GKDSI+Y N VEVE  V+  +  F + KK GDDLFD L+T  LN
Sbjct: 345 HKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKDGDDLFDRLNTQVLN 404

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  AN+ VAI+CNHQR
Sbjct: 405 EHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQR 464

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           SV KSH+  M  L EK+   +  + +   +                    +   E   K+
Sbjct: 465 SVPKSHEKSMENLKEKIKAKREAINKCEAEY-------------------HSRDEKKGKQ 505

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+++VPIEKIFNK+   
Sbjct: 506 LERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKNDVPIEKIFNKTQRT 565

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+ + D ++RF
Sbjct: 566 KFLWAVHMADENYRF 580


>B0WA62_CULQU (tr|B0WA62) Putative uncharacterized protein OS=Culex
           quinquefasciatus GN=CpipJ_CPIJ004010 PE=3 SV=1
          Length = 962

 Score =  480 bits (1236), Expect = e-133,   Method: Compositional matrix adjust.
 Identities = 254/552 (46%), Positives = 349/552 (63%), Gaps = 28/552 (5%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY P    VK  Y GK + L+ D EEVA  YA M + +Y  KD F 
Sbjct: 418 KWNFLEHKGPVFAPPYDPLPENVKFEYDGKVMKLSQDTEEVAGFYARMIEHEYTSKDVFN 477

Query: 413 ENFWNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +   +   I++LK C+F  ++ +                           
Sbjct: 478 DNFFKDWRKTMTSSEREKIKDLKKCNFKYMHAYFTDLSEKNRNRSKEEKLALKEQNEALV 537

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                  +DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRR+ P D++IN  KD+  P+ 
Sbjct: 538 KEYGICNIDGHKEKIGNFRIEPPGLFRGRGEHPKMGLVKRRVMPEDVIINCAKDSVYPKA 597

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G RWKE+RHDNTV+WLA W + +  ++ KYV L  SS LKG+ D +KYE AR L  +
Sbjct: 598 P-EGHRWKEVRHDNTVSWLASWTENVQGQV-KYVMLNPSSKLKGEKDWQKYETARRLLKH 655

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IR  Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE++  
Sbjct: 656 IDKIRDTYRDEWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIEL 715

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+FLGKDSI+Y N VEVE  V+  +  F+++KK GDDLFD L+TS LN
Sbjct: 716 HKELNGKENVVVFDFLGKDSIRYYNEVEVEKRVFKNLELFKENKKPGDDLFDRLNTSVLN 775

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            HL++LM GLTAKVFRTFNAS TL + L + T  +  V EK++ Y  AN+ VAI+CNHQR
Sbjct: 776 EHLRDLMDGLTAKVFRTFNASFTLQNQLAELTDPNMTVPEKMLAYNRANRAVAILCNHQR 835

Query: 765 SVSKSHDTQMTRLNEKL----DELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEA 820
           +V K+HD  M+ L EK+    + ++   +EL+ D+ R                 ++  + 
Sbjct: 836 AVPKTHDKSMSNLKEKIRLKKEAVETCQRELK-DMKRG-----------GSVKGSVDRDK 883

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
            +K++ +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+ +VPIEKIFNK
Sbjct: 884 KQKQLERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKFDVPIEKIFNK 943

Query: 881 SLLAKFTWAMDV 892
           +   KF WA+D+
Sbjct: 944 TQRDKFRWAIDM 955


>Q90WS0_FUGRU (tr|Q90WS0) Topoisomerase I alpha OS=Fugu rubripes GN=top1alpha
           PE=4 SV=1
          Length = 767

 Score =  478 bits (1230), Expect = e-132,   Method: Compositional matrix adjust.
 Identities = 258/562 (45%), Positives = 342/562 (60%), Gaps = 19/562 (3%)

Query: 349 SGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYM 406
           S DG K W  L H G +F PPY+P   +VK  Y GK + L A  EEVAT +A M D +Y 
Sbjct: 213 STDGSK-WRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYT 271

Query: 407 LKDKFKENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
            KD F++NF+ DWRK +       I +L  C+F  + D+                     
Sbjct: 272 TKDVFRKNFFKDWRKEMTSEEKSKITDLNKCNFAGMNDYFKAQSEARKQMSKEEKQKIKE 331

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                     + I+D  KE++GNFR+EPPGLFRGRG+HPKMG LKRRIRP DI+IN  KD
Sbjct: 332 DNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKD 391

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
           +  P+ P PG +WKE+RHDN VTWLA W + I   + KY+ L  SS +KG+ D +KYE A
Sbjct: 392 SKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETA 449

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTL 643
           R LK  +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L
Sbjct: 450 RRLKKCVDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 509

Query: 644 KVENVT-----REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDM 698
           +VE++       +    ++F+FLGKDSI+Y N + VE  V+  +  F ++K+ GDDLFD 
Sbjct: 510 RVEHINLYPKLDDQEYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDLFDR 569

Query: 699 LDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK-DTKDGDVGEKIVVYQHANKQVA 757
           L+TS LN HL+ELM GLTAKVFRT+NASITL   L +    D  V  KI+ Y  AN+ VA
Sbjct: 570 LNTSILNKHLQELMDGLTAKVFRTYNASITLQQQLKELSCSDDSVPAKILSYNRANRAVA 629

Query: 758 IICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLS 817
           I+CNHQR+  K+ +  M  L  K+DE Q  L   R  L  A+                 +
Sbjct: 630 ILCNHQRAPPKTFEKSMQNLQTKIDEKQKQLSAARKQLKAAKAEHKASHDDKSKK----A 685

Query: 818 SEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKI 877
            E   K + +   ++ K+Q     +E+ K +ALGTSK+NYLDPRI+VAWCK+  +PIEKI
Sbjct: 686 VEVKRKAVQRIEEQLMKLQVQATDREENKQIALGTSKLNYLDPRISVAWCKKFGIPIEKI 745

Query: 878 FNKSLLAKFTWAMDV-DPDFRF 898
           +NK+   KF WA+D+ + DF F
Sbjct: 746 YNKTQREKFAWAIDMAEKDFEF 767


>A8Q2Z1_BRUMA (tr|A8Q2Z1) DNA topoisomerase I, putative OS=Brugia malayi
           GN=Bm1_41680 PE=3 SV=1
          Length = 751

 Score =  476 bits (1224), Expect = e-132,   Method: Compositional matrix adjust.
 Identities = 255/558 (45%), Positives = 342/558 (61%), Gaps = 32/558 (5%)

Query: 355 KWTTLVHNGVIFPPPY--QPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW +L H G IF PPY   P  +   Y GK + L    EEVA+ YA + + +Y  KD F 
Sbjct: 212 KWYSLSHKGPIFAPPYVSLPESIHFKYDGKVMKLAPLTEEVASFYAKILEHEYTTKDIFN 271

Query: 413 ENFWNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK++   +   I +L  CDF  ++D                            
Sbjct: 272 KNFFTDWRKVMTPAEREKITDLTKCDFREMHDHYIKLREERRSLSKEEKQKLKEIKQEEA 331

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                A +DG K+K+GNFR+EPP LFRGRG HPKMG+LK+R+ P D++IN  KD+ IP+ 
Sbjct: 332 KIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHPKMGRLKKRVNPEDVIINCSKDSEIPKP 391

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G RWKE+RHDNTVTWL  W D I   + KY+ L  SS +KG+ D EK+E AR LKD 
Sbjct: 392 P-EGHRWKEVRHDNTVTWLCSWTDNILGSI-KYIMLNPSSKIKGEKDYEKFETARRLKDI 449

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEA-DTVGCCTLKVENVT 649
           +G+IR  YTKD  SK++  +Q AVA Y IDKLALRAGNEKD DEA DTVGCC+L+ E++ 
Sbjct: 450 VGSIRENYTKDLKSKEMRVRQRAVALYFIDKLALRAGNEKDVDEAADTVGCCSLRCEHI- 508

Query: 650 REAPNKL-------KFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTS 702
            +   KL       +F+FLGKDSI+Y N V VE  V+  +  F ++K G DDLFD LDT+
Sbjct: 509 -QLHEKLDDNDYVVEFDFLGKDSIRYYNKVPVEKRVFKNLKLFMENKSGSDDLFDRLDTA 567

Query: 703 KLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVG-EKIVVYQHANKQVAIICN 761
            LN +L+ LMPGLTAKVFRT+NASITL   L+K TKD     E ++ Y  AN+QVAI+CN
Sbjct: 568 SLNKYLQSLMPGLTAKVFRTYNASITLQQQLDKLTKDDSTAPELLLCYNRANRQVAILCN 627

Query: 762 HQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEAL 821
           HQR+V KSH+  M       + L+A +K  +T                     + + +  
Sbjct: 628 HQRAVPKSHEKSM-------ENLKAKIKAKKT-------ELKEAKEELEKAHSDTAKQRA 673

Query: 822 EKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKS 881
            K++ +   ++ K++     K++ K +AL TSK+NYLDPRI+VAWCK+++VPIEKIFNK+
Sbjct: 674 TKRVDRVKEQLRKLKIQRTDKDENKQIALSTSKLNYLDPRISVAWCKKYQVPIEKIFNKT 733

Query: 882 LLAKFTWAMDV-DPDFRF 898
              KF WA+D+ D ++ F
Sbjct: 734 QREKFRWAIDMADENYVF 751


>Q7QH57_ANOGA (tr|Q7QH57) AGAP004078-PA OS=Anopheles gambiae GN=AGAP004078 PE=3
           SV=4
          Length = 969

 Score =  474 bits (1220), Expect = e-131,   Method: Compositional matrix adjust.
 Identities = 249/555 (44%), Positives = 343/555 (61%), Gaps = 37/555 (6%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY P    VK +Y GK + L+ D EEVA  YA M + DY  K  F 
Sbjct: 441 KWKYLEHKGPVFAPPYDPLPSHVKFMYDGKEMKLSQDAEEVAGFYARMLEHDYTSKQAFN 500

Query: 413 ENFWNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +   +   I +L+ C+F P+  +                           
Sbjct: 501 DNFFKDWRKTMTPHERERITDLEKCNFRPMAAYFAEIAEQNRNRSKEEKAALKAANEQLT 560

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                 ++DG KEK+GNF++EPPGLFRGRGEHPKMG +KRR+ P D++IN  +D+ IP  
Sbjct: 561 KEYGICVIDGHKEKIGNFKIEPPGLFRGRGEHPKMGLVKRRVMPEDVIINCSQDSKIP-S 619

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG RWKE+RHDNTV+WLA W + +  ++ KY+ L  SS LKG+ D +KYE AR L  +
Sbjct: 620 PPPGRRWKEVRHDNTVSWLASWVENVQGQV-KYIMLNPSSKLKGEKDWQKYETARRLLKH 678

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  IR  Y  ++ SK++  +Q AVA Y IDKLALRAGNEKDDD+ADTVGCC+L+ E++  
Sbjct: 679 IDKIRDTYRDEWKSKEMRIRQRAVAMYFIDKLALRAGNEKDDDQADTVGCCSLRYEHIAL 738

Query: 651 E-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
                   N + F+FLGKDSI+Y N VEVE  V+  +  F+++KK GDDLFD L+TS +N
Sbjct: 739 HKELNGKENVVVFDFLGKDSIRYYNEVEVEKRVFKNLELFKENKKPGDDLFDRLNTSVVN 798

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQR 764
            +LK LM GLTAKVFRTFNAS TL   L + T  +  V EK++ Y  AN+ VAI+CNHQR
Sbjct: 799 EYLKGLMDGLTAKVFRTFNASYTLQKQLEELTDPNMSVPEKLLAYNRANRAVAILCNHQR 858

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
           +V K+H+  M  L EK+   +  +++ + +  ++                        K+
Sbjct: 859 AVPKTHEKSMGNLKEKIRVKREQVEQCQKEFKKS------------------------KQ 894

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLA 884
           + +   +++K++     +++ KT+ALGTSK+NYLDPRI+VAWCK+  VPIEKIFNK+   
Sbjct: 895 LERLKEQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKFGVPIEKIFNKTQRD 954

Query: 885 KFTWAMDV-DPDFRF 898
           KF WA+D+ D ++ F
Sbjct: 955 KFRWAIDMADENYVF 969


>Q6T722_CHICK (tr|Q6T722) Mitochondrial topoisomerase I OS=Gallus gallus PE=2
           SV=1
          Length = 593

 Score =  473 bits (1218), Expect = e-131,   Method: Compositional matrix adjust.
 Identities = 258/556 (46%), Positives = 342/556 (61%), Gaps = 18/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G  F P Y+P    V+  Y GKP+ L+   EE+AT YA M D +Y  K+ F+
Sbjct: 44  KWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIATFYAKMLDHEYTTKEIFQ 103

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF+NDWRK +   +  +I+ L  CDF  I+ +                           
Sbjct: 104 NNFFNDWRKEMTPQEQEIIKQLDKCDFREIHKYFVDKNEARKALSKEEKQKLKEEADKIQ 163

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+DG +EK+GNF+ EPPGLFRGRG+HPKMG LK+RI P D++IN  KD+ IPE 
Sbjct: 164 EEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKKRIMPEDVIINCSKDSKIPEP 223

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P+ G +WKE+R DNTVTWLA W + I   L KY+ L  SS LKG+ D +K+E AR LKD 
Sbjct: 224 PV-GHKWKEVRFDNTVTWLASWTENIQNSL-KYIMLNPSSKLKGEKDWQKFEVARKLKDV 281

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IRA Y  D+ SK++ K+Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 282 VHKIRAQYQADWKSKEMKKRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIK 341

Query: 650 REA-----PNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
             +      + ++F+FLGKDSI+Y N V VE PV+  +  F K+K  GDDLFD L T+ L
Sbjct: 342 LHSKLDGQEHVVEFDFLGKDSIRYYNKVSVEKPVFKNLQLFMKNKDPGDDLFDRLSTAVL 401

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL++LM GLTAKVFRT+NASITL + L   T   D V  K++ Y  AN+ VAI+CNHQ
Sbjct: 402 NKHLQKLMNGLTAKVFRTYNASITLQEQLKALTNPEDSVAGKLLSYNRANRAVAILCNHQ 461

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           RS  K+ +  M  L  K+D  +  L++ + +L+ A                    + LE+
Sbjct: 462 RSTPKTFEKSMQNLQTKIDAKKEQLEKAQQELEEAEDEFKDKKDAKAEANVQKKKKLLER 521

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
              Q    + K+      KE+ K +ALGTSK+NYLDPRI++AWCK+  VPIEKIFNK+  
Sbjct: 522 LKEQ----LAKLNVQATDKEENKQIALGTSKLNYLDPRISIAWCKKFGVPIEKIFNKTQR 577

Query: 884 AKFTWAMDV-DPDFRF 898
            KF WA+D+ D DF F
Sbjct: 578 EKFAWAIDMTDEDFEF 593


>A9V5T5_MONBE (tr|A9V5T5) Predicted protein OS=Monosiga brevicollis GN=33512 PE=3
            SV=1
          Length = 2575

 Score =  471 bits (1211), Expect = e-130,   Method: Compositional matrix adjust.
 Identities = 246/533 (46%), Positives = 340/533 (63%), Gaps = 13/533 (2%)

Query: 351  DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
            DGQK W TL H G +FPP Y+P    V +LY GKP  L  + EE+A  YA+M   DY+ K
Sbjct: 1865 DGQK-WRTLTHRGPLFPPAYEPLPKGVHLLYDGKPYLLKPEAEEIAGFYAMMLTRDYVHK 1923

Query: 409  DKFKENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
            D F ENF +DWR  +       + ++K CDF+ I+                         
Sbjct: 1924 DIFNENFMHDWRANMTPQERKDLTDIKKCDFSLIHSHYQQRAEARKAASKEEKEKRKEAE 1983

Query: 467  XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                    +A++DG K  +GNFR+EPPGLF+GRGEHPKMGKLK R+ P D++IN+G    
Sbjct: 1984 AKLKEEYGFALMDGRKVTIGNFRIEPPGLFQGRGEHPKMGKLKLRVMPEDVIINVGPKDK 2043

Query: 527  IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
            +PE P  G +WKE++HDNTVTWLA W + I  +  KY+ L+A + +KG++D +KYE AR 
Sbjct: 2044 VPEPPA-GHKWKEVKHDNTVTWLAGWKENIQDQ-NKYIMLSADTHIKGRNDWKKYETARK 2101

Query: 587  LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKV 645
            LK+++  IR  YT+D  SK + ++Q A A Y IDKLALRAG EKD +E ADTVGCC+L+V
Sbjct: 2102 LKEHVDKIRRDYTRDLKSKLMFERQRATALYFIDKLALRAGGEKDAEEQADTVGCCSLRV 2161

Query: 646  ENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLN 705
            E++     ++L F+FLGKDSI+Y+N V+V+  V+  +  F+K K+ GD+LFD L T +LN
Sbjct: 2162 EHLELLPGDELVFDFLGKDSIRYQNQVKVDHQVWKNVGHFKKSKEPGDELFDRLRTQQLN 2221

Query: 706  AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
             +L+ LM GLTAKVFRT+NASITL D L      G V EK++ YQ AN+ VAI+CNHQR+
Sbjct: 2222 EYLQSLMDGLTAKVFRTYNASITLQDQLKSTPAGGTVEEKLLAYQRANRAVAILCNHQRA 2281

Query: 766  VSKSHDTQMTRLNEKLDELQAVLKELRTDL-DRARXXXXXXXXXXXXXXXNLSS-EALEK 823
              K+HD QM RL+E L ++Q   KEL + + +R +               +L+  + L++
Sbjct: 2282 APKTHDEQMERLDEALVKIQ---KELDSTIKERKKLKKDLRAQGSDVSKTDLNRLDVLKR 2338

Query: 824  KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
            K+ +   ++ K Q     KE+ K +AL TSK+NYLDPRI+VAWCK H+VP++K
Sbjct: 2339 KVDRLEERLHKKQIAKVDKEENKCIALSTSKLNYLDPRISVAWCKTHDVPVDK 2391


>Q86ST4_HUMAN (tr|Q86ST4) TOP1MT protein (Fragment) OS=Homo sapiens GN=TOP1MT
           PE=2 SV=1
          Length = 602

 Score =  464 bits (1193), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 248/559 (44%), Positives = 337/559 (60%), Gaps = 24/559 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G  F PPY+P    V+  Y+G+PV L+   EEVAT Y  M D +Y  K+ F+
Sbjct: 53  KWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFR 112

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+NDWRK +   +  VI++L  CDFT I+ +                           
Sbjct: 113 KNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQ 172

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+DG +EK+GNF++EPPGLFRGRG+HPKMG LKRRI P D+VIN  +D+ IPE 
Sbjct: 173 QEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPE- 231

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +WKE+R DNTVTWLA W + I   + KY+ L   S LKG++  +K+E AR L+ +
Sbjct: 232 PPAGHQWKEVRSDNTVTWLAAWTESIQNSI-KYIMLNPCSKLKGETAWQKFETARRLRGF 290

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEA-DTVGCCTLKVENVT 649
           +  IR+ Y  D+ S+++  +Q AVA Y IDKLALRAGNEK+D EA DTVGCC+L+VE+V 
Sbjct: 291 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 350

Query: 650 RE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                    + ++F+FLGKD I+Y N V VE PVY  +  F ++K   DDLFD L T+ L
Sbjct: 351 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 410

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL+ELM GLTAKVFRT+NASITL + L   T+  D +  KI+ Y  AN+ VAI+CNHQ
Sbjct: 411 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 470

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+   + +  M         LQ  ++  +  +  AR                 S   LEK
Sbjct: 471 RATPSTFEKSM-------QNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEK 523

Query: 824 K---ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           K   + +   ++ ++      KE+ K VALGTSK+NYLDPRI++AWCKR  VP+EKI++K
Sbjct: 524 KRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSK 583

Query: 881 SLLAKFTWAMDV-DPDFRF 898
           +   +F WA+ +   DF F
Sbjct: 584 TQRERFAWALAMAGEDFEF 602


>A8KA78_HUMAN (tr|A8KA78) cDNA FLJ77890, highly similar to Homo sapiens type I
           DNA topoisomerase gene OS=Homo sapiens GN=TOP1 PE=2 SV=1
          Length = 765

 Score =  464 bits (1193), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 250/556 (44%), Positives = 338/556 (60%), Gaps = 18/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+   EEVAT +A M D +Y  K+ F+
Sbjct: 216 KWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFR 275

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +   + ++I NL  CDFT +  +                           
Sbjct: 276 KNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLL 335

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+D  KE++ NF++EPPGLFRGRG HPKMG LKRRI P DI+IN  KDA +P  
Sbjct: 336 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVP-S 394

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWL  W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 395 PPPGHKWKEVRHDNKVTWLVSWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 453

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 454 VDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIN 513

Query: 650 RE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                      ++F+FLGKDSI+Y N V VE  V+  +  F ++K+  DDLFD L+T  L
Sbjct: 514 LHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGIL 573

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQ 763
           N HL++LM GLTAKVFRT+NASITL   L + T  D ++  KI+ Y  AN+ VAI+CNHQ
Sbjct: 574 NKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQ 633

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+  K+ +  M  L  K+D  +  L + R DL  A+                   E+ +K
Sbjct: 634 RAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVV----ESKKK 689

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
            + +   ++ K++     +E+ K +ALGTSK+NYLDPRITVAWCK+  VPIEKI+NK+  
Sbjct: 690 AVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQR 749

Query: 884 AKFTWAMDV-DPDFRF 898
            KF WA+D+ D D+ F
Sbjct: 750 EKFAWAIDMADEDYEF 765


>Q86V82_HUMAN (tr|Q86V82) Topoisomerase (DNA) I, mitochondrial OS=Homo sapiens
           GN=TOP1MT PE=2 SV=1
          Length = 601

 Score =  464 bits (1193), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 248/559 (44%), Positives = 337/559 (60%), Gaps = 24/559 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G  F PPY+P    V+  Y+G+PV L+   EEVAT Y  M D +Y  K+ F+
Sbjct: 52  KWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFR 111

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+NDWRK +   +  VI++L  CDFT I+ +                           
Sbjct: 112 KNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQ 171

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+DG +EK+GNF++EPPGLFRGRG+HPKMG LKRRI P D+VIN  +D+ IPE 
Sbjct: 172 QEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPE- 230

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +WKE+R DNTVTWLA W + I   + KY+ L   S LKG++  +K+E AR L+ +
Sbjct: 231 PPAGHQWKEVRSDNTVTWLAAWTESIQNSI-KYIMLNPCSKLKGETAWQKFETARRLRGF 289

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEA-DTVGCCTLKVENVT 649
           +  IR+ Y  D+ S+++  +Q AVA Y IDKLALRAGNEK+D EA DTVGCC+L+VE+V 
Sbjct: 290 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 349

Query: 650 RE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                    + ++F+FLGKD I+Y N V VE PVY  +  F ++K   DDLFD L T+ L
Sbjct: 350 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 409

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL+ELM GLTAKVFRT+NASITL + L   T+  D +  KI+ Y  AN+ VAI+CNHQ
Sbjct: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+   + +  M         LQ  ++  +  +  AR                 S   LEK
Sbjct: 470 RATPSTFEKSM-------QNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEK 522

Query: 824 K---ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           K   + +   ++ ++      KE+ K VALGTSK+NYLDPRI++AWCKR  VP+EKI++K
Sbjct: 523 KRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSK 582

Query: 881 SLLAKFTWAMDV-DPDFRF 898
           +   +F WA+ +   DF F
Sbjct: 583 TQRERFAWALAMAGEDFEF 601


>Q1ED17_DANRE (tr|Q1ED17) Topoisomerase (DNA) I, like OS=Danio rerio GN=top1l
           PE=2 SV=1
          Length = 758

 Score =  463 bits (1192), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 251/556 (45%), Positives = 339/556 (60%), Gaps = 18/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+ + EEVAT ++ M D +Y  KD F+
Sbjct: 209 KWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFR 268

Query: 413 ENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +       I +L  CDF+ + ++                           
Sbjct: 269 KNFFKDWRKEMTSEEKSKITDLNKCDFSNMSEYFKAQSEARKAMTKEEKLKIKEENERIL 328

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+D  KE++ NFR+EPPGLFRGRG+HPKMG LKRRIRP DI+IN  KD+  P  
Sbjct: 329 QEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHP-T 387

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWL  W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 388 PPPGTKWKEVRHDNKVTWLVSWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 446

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IR+ Y  D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++T
Sbjct: 447 VDRIRSQYRDDWKSKEMKIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHLT 506

Query: 650 REAPNK-----LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                      ++F+FLGKDSI+Y N V VE  V+  +  F +DK+  DDLFD L+TS L
Sbjct: 507 LHPEMDGQEFVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMEDKEPEDDLFDRLNTSIL 566

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL+ELM GLTAKVFRT+NASITL   LN+ T   D V  KI+ Y  AN+ VAI+CNHQ
Sbjct: 567 NKHLQELMDGLTAKVFRTYNASITLQQQLNELTNSEDNVPAKILSYNRANRAVAILCNHQ 626

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+  K+ +  M  L  K+D  +  L E + +L  A+                   +AL++
Sbjct: 627 RAPPKTFEKSMQNLQTKIDAKKEQLVEAKRELKGAKADAKVRKDEKFKKAVEAKKKALQR 686

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
                  ++ K++     +E+ K +ALGTSK+NYLDPRI+VAWCK+  +PIEKI+NK+  
Sbjct: 687 ----VEEQLMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKFGIPIEKIYNKTQR 742

Query: 884 AKFTWAMDV-DPDFRF 898
            KF WA+D+ + D+ F
Sbjct: 743 EKFAWAIDMAEKDYEF 758


>Q5IFJ5_MACFA (tr|Q5IFJ5) TOP1 (Fragment) OS=Macaca fascicularis PE=2 SV=1
          Length = 560

 Score =  463 bits (1191), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 250/556 (44%), Positives = 338/556 (60%), Gaps = 18/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+   EEVAT +A M D +Y  K+ F+
Sbjct: 11  KWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFR 70

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +   + ++I NL  CDFT +  +                           
Sbjct: 71  KNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLL 130

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+D  KE++ NF++EPPGLFRGRG HPKMG LKRRI P DI+IN  KDA +P  
Sbjct: 131 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVP-S 189

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWL  W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 190 PPPGHKWKEVRHDNKVTWLVSWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 248

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 249 VDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIN 308

Query: 650 RE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                      ++F+FLGKDSI+Y N V VE  V+  +  F ++K+  DDLFD L+T  L
Sbjct: 309 LHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGIL 368

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQ 763
           N HL++LM GLTAKVFRT+NASITL   L + T  D ++  KI+ Y  AN+ VAI+CNHQ
Sbjct: 369 NKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQ 428

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+  K+ +  M  L  K+D  +  L + R DL  A+                   E+ +K
Sbjct: 429 RAPPKTFEKSMMNLQSKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVV----ESKKK 484

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
            + +   ++ K++     +E+ K +ALGTSK+NYLDPRITVAWCK+  VPIEKI+NK+  
Sbjct: 485 AVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQR 544

Query: 884 AKFTWAMDV-DPDFRF 898
            KF WA+D+ D D+ F
Sbjct: 545 EKFAWAIDMADEDYEF 560


>Q24BB2_TETTH (tr|Q24BB2) Eukaryotic DNA topoisomerase I, catalytic core family
           protein OS=Tetrahymena thermophila SB210
           GN=TTHERM_01299650 PE=3 SV=1
          Length = 713

 Score =  462 bits (1190), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 246/579 (42%), Positives = 339/579 (58%), Gaps = 35/579 (6%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           KW  L H+GV+FP  +Q H V+  Y GKP+DL   QEE+AT ++    TD+  K K++EN
Sbjct: 135 KWKYLEHHGVLFPDYWQKHNVRPRYDGKPIDLNLLQEEMATYWSQTLGTDWEHKPKYREN 194

Query: 415 FWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 474
           F   +    GK+    +    DFTPI                                  
Sbjct: 195 FSKQFLDTFGKDKGKYDFDKFDFTPIKIHLEEQKEIRKNRSKEEKNQEKQKKERLSDYYA 254

Query: 475 WAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIP- 533
            AI+DG +EKVG F +EPP LF+GRGEHPKMG +K RI+P  +VINI KDAP+P+C +P 
Sbjct: 255 GAILDGFREKVGQFMIEPPTLFKGRGEHPKMGMMKGRIQPEAVVINISKDAPVPKCSVPD 314

Query: 534 -----------------GERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQS 576
                            G  W EI H   VTWLA + D    K  KY+FL+A S LK ++
Sbjct: 315 CIHICRQIFNEFPKKQLGHGWSEIVHKQDVTWLASYKDDSVKKQHKYIFLSAESKLKAEN 374

Query: 577 DKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEAD 636
           DK+KYEKAR LK+ IG IR  Y +   S D   +Q+  ATYLIDKLALR GNEK ++EAD
Sbjct: 375 DKKKYEKARRLKNLIGQIRENYERKLRSSDPVDRQLGTATYLIDKLALRVGNEKSEEEAD 434

Query: 637 TVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLF 696
           TVGCC+L+VE++      ++ F+FLGKDS++Y+NTV+V   V+  +  F K+KK GDDLF
Sbjct: 435 TVGCCSLRVEHIQVIEDTQIGFDFLGKDSMRYQNTVKVTEIVWKNMQSFIKNKKPGDDLF 494

Query: 697 DMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDG----DVGEKIVVYQHA 752
           D +D S LN +LK  M GLTAKVFRT+NAS TL   L+K  ++G    D+ +K+  Y  A
Sbjct: 495 DRIDASSLNEYLKSQMEGLTAKVFRTYNASHTLQKELDKADEEGLDKMDLKDKLNFYDEA 554

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXX 812
           N+ VAI+CNHQ++V K+ D  + ++ ++++  +   KEL T L++ +             
Sbjct: 555 NRNVAILCNHQKTVGKNFDVMVGKMEQRINVYKDYEKELHTHLNKCKKNGVNAYEKEVIL 614

Query: 813 XXN-------------LSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLD 859
                            + E +++ I +   KI++ Q   ++KE  K +ALGTSK NY D
Sbjct: 615 EEKDDGKHKMFVKKFPGTKEKIQEAIEKIKKKIDEEQNKKQSKEKNKEIALGTSKTNYND 674

Query: 860 PRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           PRI+V WCK+ EVP+EK+F K+L+AKF WAMD D ++ F
Sbjct: 675 PRISVVWCKKWEVPVEKVFPKTLIAKFVWAMDTDLEWSF 713


>B3S6N7_TRIAD (tr|B3S6N7) Putative uncharacterized protein (Fragment)
           OS=Trichoplax adhaerens GN=TRIADDRAFT_30199 PE=4 SV=1
          Length = 560

 Score =  462 bits (1189), Expect = e-128,   Method: Compositional matrix adjust.
 Identities = 248/557 (44%), Positives = 342/557 (61%), Gaps = 21/557 (3%)

Query: 349 SGDGQKKWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYM 406
           + D   KW TL H G +  PPY+  P  V+  Y G+   L+   EE A  YA M D DY 
Sbjct: 5   TKDNSVKWKTLEHKGPLLAPPYERLPSNVQFYYDGQTFPLSDKTEEAAGFYAKMLDHDYT 64

Query: 407 LKDKFKENFWNDWRKLLG---KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXX 463
            K  F +NFW D+RK +    KNH I+    CDF+ I ++                    
Sbjct: 65  QKKIFNDNFWTDFRKEMTPAEKNH-IKVFSKCDFSKIAEYYKMKAEERRNMSKEEKNKLK 123

Query: 464 XXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGK 523
                      + I+DG +++VGNF++EPPGLFRGRG+HPK GK+KRRI   DI+INIGK
Sbjct: 124 KENEELMQEYGFCIIDGHRQRVGNFKIEPPGLFRGRGDHPKQGKIKRRIEAKDIIINIGK 183

Query: 524 DAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEK 583
           DA +P  P PG++WKE+R+DN VTWLA W + IN  + KY+ L  +S +K + D +KYE 
Sbjct: 184 DAKLP-APPPGQKWKEVRYDNKVTWLASWTENINGSI-KYIMLNPTSKIKAEKDYQKYET 241

Query: 584 ARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCT 642
           AR LK YI  IR  Y  D+ SK++  +Q + A Y ID+LALRAG+EK++ E ADTVGCC+
Sbjct: 242 ARKLKRYIDKIRQDYKADWKSKEMRIRQRSAALYFIDRLALRAGHEKEEGESADTVGCCS 301

Query: 643 LKVENV-----TREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFD 697
           L+ E++       +  N ++F+FLGKDSI+Y N V VE  VY  +  F K+KK GDDLFD
Sbjct: 302 LRYEHIKLHDQLEDKMNVVEFDFLGKDSIRYVNQVPVEKQVYKNLKLFCKNKKKGDDLFD 361

Query: 698 MLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK--DTKDGDVGEKIVVYQHANKQ 755
            L T+ LN +L ELM GLTAKVFRT+NAS TL + L++  D K   + +KI++Y  +N+ 
Sbjct: 362 RLSTTSLNKYLSELMEGLTAKVFRTYNASYTLQEQLHQVIDPK-MSIEDKILIYNRSNRA 420

Query: 756 VAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXN 815
           VAI+CNHQR+VSK+ D QM+ L EK+++ +  LKE + +  RA+                
Sbjct: 421 VAILCNHQRTVSKTFDKQMSNLREKIEKKEQQLKEAKKEEKRAKSDLKERKDESSKKLYE 480

Query: 816 LSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIE 875
              +  E      N ++ K+      K + K VAL TSK+NY+DPRI+VAWCK++EVP+E
Sbjct: 481 KRKKKTE----MLNRQLHKLNLTETDKVENKEVALSTSKLNYMDPRISVAWCKKNEVPVE 536

Query: 876 KIFNKSLLAKFTWAMDV 892
           K+FNK+   KF WA+++
Sbjct: 537 KVFNKTQREKFKWAIEM 553


>Q4T6N6_TETNG (tr|Q4T6N6) Chromosome 9 SCAF8684, whole genome shotgun sequence.
           (Fragment) OS=Tetraodon nigroviridis
           GN=GSTENG00006211001 PE=4 SV=1
          Length = 783

 Score =  461 bits (1186), Expect = e-127,   Method: Compositional matrix adjust.
 Identities = 255/588 (43%), Positives = 341/588 (57%), Gaps = 50/588 (8%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P   +VK  Y GKP+ L A  EEVAT +A M D +Y  KD F+
Sbjct: 202 KWRFLGHKGPVFAPPYEPLPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFR 261

Query: 413 ENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +       I +L  C+FT + ++                           
Sbjct: 262 KNFFKDWRKEMTSEEKSKITDLNKCNFTEMNEYFKAQSEARKQMSKEEKQKIKEENERIL 321

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+D  KE++GNFR+EPPGLFRGRG+HPKMG LKRRIRP DI+IN  KD+  P+ 
Sbjct: 322 QEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPK- 380

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWLA W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 381 PPPGTKWKEVRHDNKVTWLASWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 439

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 440 VDRIRTQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIN 499

Query: 650 -----REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLD---- 700
                 +    ++F+FLGKDSI+Y N + VE  V+  +  F ++K+ GDDLFD L+    
Sbjct: 500 LYPKLDDQEFVVEFDFLGKDSIRYYNKIPVEKRVFKNLQLFLENKQPGDDLFDRLNVRIS 559

Query: 701 ----------------------------TSKLNAHLKELMPGLTAKVFRTFNASITLDDM 732
                                       TS LN HL+ELM GLTAKVFRT+NASITL   
Sbjct: 560 ECRPVKIRCASAGAVSGCCTRPFFSLPQTSILNKHLQELMDGLTAKVFRTYNASITLQQQ 619

Query: 733 LNK-DTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKEL 791
           L +    D  +  KI+ Y  AN+ VAI+CNHQR+  K+ +  M  L  K+DE Q  L   
Sbjct: 620 LKELSCSDDSLPAKILSYNRANRAVAILCNHQRAPPKTFEKSMQNLQTKIDEKQKQLSAA 679

Query: 792 RTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALG 851
           R  L  A+                 + E   K + +   ++ K+Q     +E+ K +ALG
Sbjct: 680 RKQLKGAKAEHKASHDDKSKK----AVEVKRKAVQRIEEQLMKLQVQATDREENKQIALG 735

Query: 852 TSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
           TSK+NYLDPRI+VAWCK+  +PIEKI+NK+   KF WA+D+ + DF F
Sbjct: 736 TSKLNYLDPRISVAWCKKFGIPIEKIYNKTQREKFAWAIDMAEKDFEF 783


>A9Q1D5_PANTR (tr|A9Q1D5) Mitochondrial topoisomerase I OS=Pan troglodytes
           GN=TOP1 PE=2 SV=1
          Length = 601

 Score =  460 bits (1183), Expect = e-127,   Method: Compositional matrix adjust.
 Identities = 246/559 (44%), Positives = 335/559 (59%), Gaps = 24/559 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G  F PPY+P    V+  Y+GKPV L+   EEVAT Y  M   +Y  K+ F+
Sbjct: 52  KWRQLEHKGPYFAPPYEPLPDGVRFFYEGKPVRLSVAAEEVATFYGRMLGHEYTTKEVFR 111

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+NDWRK +   +  VI++L  CDFT I+ +                           
Sbjct: 112 KNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQ 171

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+DG +EK+GNF++EPPGLFRGRG+HPKMG LKRRI P D+VIN  +D+ IPE 
Sbjct: 172 REFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRIMPEDVVINCSRDSKIPE- 230

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +WKE+R DNTVTWLA W + +   + KY+ L   S LKG++  +K+E AR L+ +
Sbjct: 231 PPAGHQWKEVRSDNTVTWLAAWTESVQNSI-KYIMLNPCSKLKGETAWQKFETARRLRGF 289

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEA-DTVGCCTLKVENVT 649
           +  IR+ Y  D+ S+++  +Q AVA Y IDKLALRAGNEK+D EA DTVGCC+L+VE+V 
Sbjct: 290 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 349

Query: 650 RE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                    + ++F+FLGKD I+Y N V VE PVY  +  F + K   D+LFD L T+ L
Sbjct: 350 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNLFDRLTTTSL 409

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL+ELM GLTAKVFRT+NASITL + L   T+  D +  KI+ Y  AN+ VAI+CNHQ
Sbjct: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+   + +  M         LQ  ++  +  +  AR                 S   LEK
Sbjct: 470 RATPSTFEKSM-------QNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEK 522

Query: 824 K---ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           K   + +   ++ ++      KE+ K VALGTSK+NYLDPRI++AWCKR  VP+EKI++K
Sbjct: 523 KRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSK 582

Query: 881 SLLAKFTWAMDV-DPDFRF 898
           +   +F WA+ +   DF F
Sbjct: 583 TQRERFAWALAMAGEDFEF 601


>Q90WS1_FUGRU (tr|Q90WS1) Topoisomerase I beta OS=Fugu rubripes GN=top1beta PE=3
           SV=1
          Length = 753

 Score =  457 bits (1176), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 248/556 (44%), Positives = 339/556 (60%), Gaps = 18/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK   L A  EEVAT +A M D +Y  KD F+
Sbjct: 204 KWKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFAKMLDHEYTTKDVFR 263

Query: 413 ENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +       I +LK CDF+ ++ +                           
Sbjct: 264 KNFFKDWRKEMTSEEKAKITDLKKCDFSEMHQYFKAQSEARKAMTKEEKLKIKEENERLL 323

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+D  KE++ NFR+EPPGLFRGRG+HPKMG LKRRIRP DI+IN  KD+  PE 
Sbjct: 324 QQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPQDIIINCSKDSKYPEP 383

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWL  W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 384 P-PGTKWKEVRHDNKVTWLVSWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 441

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENV- 648
           +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 442 VDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIK 501

Query: 649 ----TREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                      ++F+FLGKDSI+Y N V VE  V+  +  F ++K+  DDLFD L+TS L
Sbjct: 502 LYPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKEPDDDLFDRLNTSIL 561

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQ 763
           N HL+ELM GLTAKVFRT+NASITL   L + T  + ++  KI+ Y  AN+ VAI+CNHQ
Sbjct: 562 NKHLQELMDGLTAKVFRTYNASITLQAQLKELTSAEENIPAKILSYNRANRAVAILCNHQ 621

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+  K+ +  M  L  K+D  +A L   + +L  A+                   +A+++
Sbjct: 622 RAPPKTFEKSMQNLQTKIDAKKAQLSAAKRELKSAKADAKVRRDEKSKKAVEAKKKAVQR 681

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
                + ++ K++     +E+ K +ALGTSK+NYLDPRI+VAWCK+  +P+EKI+NK+  
Sbjct: 682 ----IDDQLMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKWGIPVEKIYNKTQR 737

Query: 884 AKFTWAMDV-DPDFRF 898
            KF WA+D+ + D+ F
Sbjct: 738 EKFAWAIDMAEDDYEF 753


>Q5CN58_CRYHO (tr|Q5CN58) DNA topoisomerase I OS=Cryptosporidium hominis
           GN=Chro.70373 PE=3 SV=1
          Length = 641

 Score =  457 bits (1175), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 254/599 (42%), Positives = 350/599 (58%), Gaps = 56/599 (9%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H GV+F PPY+ H V + Y G+ + L  + EE+A+ ++VM+DT++  K+KF  N
Sbjct: 44  QWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMKDTEWAQKEKFSNN 103

Query: 415 FWNDWRKLLGKNHVIQN---LKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXX 471
               +   +     + N    + C+F  I  +                            
Sbjct: 104 VRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEEKELQKKCRGDQES 163

Query: 472 XXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECP 531
              +A+VD +KEKVGNFR+EPPGLF+GRGEHPK G LKRRI P D+ +NI +DAP+P+ P
Sbjct: 164 PFVYALVDWIKEKVGNFRIEPPGLFKGRGEHPKSGMLKRRIFPEDVTLNIAEDAPVPKVP 223

Query: 532 --IPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
             + G  WK+I HDNTVTWLA++ D IN + FKY+FL+ASS  KG SD  KYEKAR LKD
Sbjct: 224 NSMKGHAWKDIFHDNTVTWLAYYRDSINNQ-FKYIFLSASSGFKGMSDYNKYEKARKLKD 282

Query: 590 YIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTVGCCTLKVENV 648
           +I  IR+ Y K  TS DIT++Q+  ATYLID LALR G EKD D+EADTVGCC+L+VE++
Sbjct: 283 HIDAIRSDYRKKMTSGDITQRQLGTATYLIDFLALRVGGEKDTDEEADTVGCCSLRVEHI 342

Query: 649 TREAPNK-LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAH 707
           T     K +  +FLGKDSI+Y NTV ++   +N +  F ++K   +++FD ++ S LN +
Sbjct: 343 TFNQQEKSITLDFLGKDSIRYYNTVVIDPSAFNNLTIFCRNKDKMENVFDQINMSSLNQY 402

Query: 708 LKELMPGLTAKVFRTFNASITLDDML--------------------------------NK 735
           LK +MP L+AKVFRTFNASITL+  L                                N 
Sbjct: 403 LKSIMPELSAKVFRTFNASITLERELSKISAKSAVKSEKKTKMELESCLKDELNLSNFNN 462

Query: 736 DTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR-------LNEKLDELQAVL 788
           +    +V + +  Y  AN++VAI+CNHQRSV K H++ M +       L E L   +A L
Sbjct: 463 EVDITNVNDILRFYNDANREVAILCNHQRSVPKQHESSMEKMIKQQQELEEDLKICEAFL 522

Query: 789 KELR--------TDLDR-ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDM 839
           K L+         DL + +                N S + ++KKI    +KI  +   +
Sbjct: 523 KILKKNNKSVTMNDLPKLSTEVSFNGKQRKYPINLNSSLDVVQKKIDSIKSKISNLYLKI 582

Query: 840 KTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           K K+D KTVAL TSKINY+DPRI+VA+CK++++PI+KIFN+SL  KF WAM    DF F
Sbjct: 583 KIKDDNKTVALNTSKINYMDPRISVAFCKKYDLPIDKIFNRSLRTKFPWAMYTRSDFSF 641


>Q5CY81_CRYPV (tr|Q5CY81) Eukaryotic DNA topoisomerase I (Fragment)
           OS=Cryptosporidium parvum Iowa II GN=cgd7_3350 PE=3 SV=1
          Length = 653

 Score =  456 bits (1172), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 254/599 (42%), Positives = 350/599 (58%), Gaps = 56/599 (9%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H GV+F PPY+ H V + Y G+ + L  + EE+A+ ++VM+DT++  K+KF  N
Sbjct: 56  QWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMKDTEWAQKEKFSNN 115

Query: 415 FWNDWRKLLGKNHVIQN---LKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXX 471
               +   +     + N    + C+F  I  +                            
Sbjct: 116 VRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEEKELQKKCRGDQES 175

Query: 472 XXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECP 531
              +A+VD +KEKVGNFR+EPPGLF+GRGEHPK G LKRRI P D+ +NI +DAP+P+ P
Sbjct: 176 PFVYALVDWIKEKVGNFRIEPPGLFKGRGEHPKSGMLKRRIFPEDVTLNIAEDAPVPKVP 235

Query: 532 --IPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
             + G  WK+I HDNTVTWLA++ D IN + FKY+FL+ASS  KG SD  KYEKAR LKD
Sbjct: 236 NSMKGHAWKDIFHDNTVTWLAYYRDSINNQ-FKYIFLSASSGFKGMSDYNKYEKARKLKD 294

Query: 590 YIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTVGCCTLKVENV 648
           +I  IR  Y K  TS DIT++Q+  ATYLID LALR G EKD D+EADTVGCC+L+VE++
Sbjct: 295 HIDAIRDDYRKKMTSGDITQRQLGTATYLIDFLALRVGGEKDTDEEADTVGCCSLRVEHI 354

Query: 649 TREAPNK-LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAH 707
           T     K +  +FLGKDSI+Y NTV ++   +N +  F ++K   +++FD ++ S LN +
Sbjct: 355 TFNQQEKSITLDFLGKDSIRYYNTVVIDPSAFNNLTIFCRNKDKMENVFDQINMSSLNQY 414

Query: 708 LKELMPGLTAKVFRTFNASITLDDML--------------------------------NK 735
           LK +MP L+AKVFRTFNASITL+  L                                N 
Sbjct: 415 LKSIMPELSAKVFRTFNASITLERELSKISAKSAVKSEKRTKMELESYLKDELNLSNFNN 474

Query: 736 DTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR-------LNEKLDELQAVL 788
           +    +V + +  Y  AN++VAI+CNHQRSV K H++ M +       L E L   +A L
Sbjct: 475 EVDITNVNDILRFYNDANREVAILCNHQRSVPKQHESSMEKMIKQQQELEEDLKICEAFL 534

Query: 789 KELR--------TDLDR-ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDM 839
           K L+        +DL + +                N S + ++KKI    +KI  +   +
Sbjct: 535 KILKKNNKSVTISDLPKLSTEVSFNGKQRKYPINLNSSLDVVQKKIDSIKSKISNLYLKI 594

Query: 840 KTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           K K+D KTVAL TSKINY+DPRI+VA+CK++++PI+KIFN+SL  KF WAM    DF F
Sbjct: 595 KIKDDNKTVALNTSKINYMDPRISVAFCKKYDLPIDKIFNRSLRTKFPWAMYTRSDFSF 653


>P79994_CHICK (tr|P79994) DNA topoisomerase I OS=Gallus gallus PE=2 SV=1
          Length = 766

 Score =  456 bits (1172), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 243/556 (43%), Positives = 336/556 (60%), Gaps = 18/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+   EEVAT +A M D +Y  K+ F+
Sbjct: 217 KWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFAKMLDHEYTTKEIFR 276

Query: 413 ENFWNDWRKLLGKNH--VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +       I +L  CDFT +  +                           
Sbjct: 277 KNFFKDWRKEMTSEEKSTITSLSKCDFTHMSQYFKAQTEARKQMSKEEKQKIKEENERLL 336

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++D  KE++ NF++EPPGLFRGRG HPKMG LKRRI P DI+IN  KD+ +P  
Sbjct: 337 KEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDSKVPPP 396

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWL  W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 397 P-PGHKWKEVRHDNKVTWLVSWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 454

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 455 VDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIK 514

Query: 650 RE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
                      ++F+FLGKDSI+Y N V VE  V+  +  F ++K+  DDLFD L+TS L
Sbjct: 515 LHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTSIL 574

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQ 763
           N HL++LM GLTAKVFRT+NASITL   L + T  D ++  KI+ Y  AN+ VAI+CNHQ
Sbjct: 575 NKHLQDLMEGLTAKVFRTYNASITLQQQLKELTNPDDNIPAKILSYNRANRAVAILCNHQ 634

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+  K+ +  M  L  K+D  +  L + R +L  A+                 + E+ +K
Sbjct: 635 RAPPKTFEKSMMNLQSKIDAKKEQLADARRELKSAKADAKVRRDEKSKK----AVESKKK 690

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
            + +   ++ K++     +E+ K +AL TSK+NYLDPRI+VAWCK+  +PIEKI+NK+  
Sbjct: 691 AVQRIEEQLMKLEVQATDREENKQIALSTSKLNYLDPRISVAWCKKWGIPIEKIYNKTQR 750

Query: 884 AKFTWAMDV-DPDFRF 898
            KF WA+D+ + D+ F
Sbjct: 751 EKFAWAIDMAEEDYEF 766


>Q4DTW1_TRYCR (tr|Q4DTW1) DNA topoisomerase IB, large subunit, putative
           OS=Trypanosoma cruzi GN=Tc00.1047053508693.20 PE=3 SV=1
          Length = 664

 Score =  456 bits (1172), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 221/444 (49%), Positives = 292/444 (65%), Gaps = 5/444 (1%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           GQK+W TL HNGV+FPP Y+PH + + Y+G+   LT ++EEVATM+AVMR+ DY   + F
Sbjct: 45  GQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAVMREHDYYRNEIF 104

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           + NF++ WR++L K  H I+ L+ CDF PIY W                           
Sbjct: 105 RRNFFSSWREILDKRQHPIRRLELCDFEPIYQWHLREREKKLSRTKEEKKQLRLEAEKEA 164

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               W + DG KE+V NFRVEPPGLFRGRG+HP MGKLK+R+ P DI INI + +PIP+ 
Sbjct: 165 EPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHPMMGKLKKRVEPEDITINIDEFSPIPKP 224

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G RWKE+ H++ VTWLA W D I    FKYV LA SS++KGQSD  K+EKAR LK++
Sbjct: 225 P-EGHRWKEVLHEHNVTWLAMWRDSILGS-FKYVMLAPSSAIKGQSDMLKFEKARELKNH 282

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           +  IR  Y +DF S+++ K Q AVA Y IDKLALR GNEK  DEADTVGCC+L+VE++  
Sbjct: 283 VDEIRRCYIEDFESRELMKAQRAVAMYFIDKLALRVGNEKGSDEADTVGCCSLRVEHIEL 342

Query: 651 EAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKE 710
           +  + +KF+FLGKDSI+YEN   V   VY  + +F K KK GDD+FDM+  + LN HLK 
Sbjct: 343 KPDHVVKFDFLGKDSIRYENEAVVLPRVYELLRRFTKGKKTGDDIFDMITPTVLNDHLKS 402

Query: 711 LMPGLTAKVFRTFNASITLDDMLNKD--TKDGDVGEKIVVYQHANKQVAIICNHQRSVSK 768
            M GL+AKVFRT+NASITLD    +        V +K+  +  AN +VAI+CNHQ+S+SK
Sbjct: 403 FMAGLSAKVFRTYNASITLDRWFKEKPVPPSASVADKLAYFNKANTEVAILCNHQKSISK 462

Query: 769 SHDTQMTRLNEKLDELQAVLKELR 792
           +H   M +L +K    + ++  L+
Sbjct: 463 NHHNLMHQLTQKSSYTRTIIDALK 486


>Q6Y634_TRYCR (tr|Q6Y634) Type I topoisomerase OS=Trypanosoma cruzi PE=2 SV=1
          Length = 664

 Score =  455 bits (1170), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 221/447 (49%), Positives = 292/447 (65%), Gaps = 5/447 (1%)

Query: 349 SGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           S  GQK+W TL HNGV+FPP Y+PH + + Y+G+   LT ++EEVATM+AVMR+ DY   
Sbjct: 42  STKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAVMREHDYYRN 101

Query: 409 DKFKENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXX 467
           + F+ NF++ WR++L +  H I+ L+ CDF PIY W                        
Sbjct: 102 EIFRRNFFSSWREILDRRQHPIRRLELCDFEPIYQWHLREREKKLSRTKEEKKQLRLEAE 161

Query: 468 XXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPI 527
                  W + DG KE+V NFRVEPPGLFRGRG+HP MGKLK+R+ P DI INI + +PI
Sbjct: 162 KEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHPMMGKLKKRVEPEDITINIDEFSPI 221

Query: 528 PECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARML 587
           P+ P  G RWKE+ H++ VTWLA W D I    FKYV LA SS++KGQSD  K+EKAR L
Sbjct: 222 PKPP-EGHRWKEVLHEHNVTWLAMWRDSILGS-FKYVMLAPSSAIKGQSDMLKFEKAREL 279

Query: 588 KDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVEN 647
           K+++  IR  Y +DF S+++ K Q AVA Y IDKLALR GNEK  DEADTVGCC+L+VE+
Sbjct: 280 KNHVDEIRRCYIEDFESRELMKAQRAVAMYFIDKLALRVGNEKGSDEADTVGCCSLRVEH 339

Query: 648 VTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAH 707
           +  +    +KF+FLGKDSI+YEN   V   VY  + +F K KK GDD+FDM+  + LN H
Sbjct: 340 IELKPDYVVKFDFLGKDSIRYENEAVVLPRVYELLRRFTKGKKTGDDIFDMITPTVLNDH 399

Query: 708 LKELMPGLTAKVFRTFNASITLDDMLNKD--TKDGDVGEKIVVYQHANKQVAIICNHQRS 765
           LK  M GL+AKVFRT+NASITLD    +        V +K+  +  AN +VAI+CNHQ+S
Sbjct: 400 LKSFMAGLSAKVFRTYNASITLDRWFKEKPVPPSASVADKLAYFNKANTEVAILCNHQKS 459

Query: 766 VSKSHDTQMTRLNEKLDELQAVLKELR 792
           +SK+H   M +L +K    + ++  L+
Sbjct: 460 ISKNHHNLMHQLTQKSSYTRTIIDALK 486


>A8XXL4_CAEBR (tr|A8XXL4) CBR-TOP-1 protein OS=Caenorhabditis briggsae
           GN=Cbr-top-1 PE=3 SV=2
          Length = 840

 Score =  454 bits (1169), Expect = e-125,   Method: Compositional matrix adjust.
 Identities = 259/581 (44%), Positives = 340/581 (58%), Gaps = 54/581 (9%)

Query: 355 KWTTLVHNGVIFPPPY--QPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL H G +F P Y   P  V   Y G  + L+   EE AT YA + + +Y  + +F 
Sbjct: 277 KWNTLQHCGPLFAPAYIPLPDHVHFKYNGHRMKLSPAAEECATFYAGVVNHEYSSQVQFN 336

Query: 413 ENFWNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF  DWRKL+  G+   I +L  CDFT I ++                           
Sbjct: 337 TNFMKDWRKLMTSGEREKITDLAKCDFTHIVEYQNEQREIRKAMTKEEKAKIKEEKAQEV 396

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                AI+DG KEK+ NFR+EPPG+FRGRG HPKMG +K+RI P D+++N GKD+ IP+ 
Sbjct: 397 VDYGIAIIDGHKEKIANFRIEPPGVFRGRGGHPKMGFIKKRIVPEDVIVNCGKDSVIPKP 456

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P+ G +WKE+RHDNTV+WL  W + +  +  KY+ L ASS +KG  D EKYE AR LK  
Sbjct: 457 PL-GHKWKEVRHDNTVSWLCSWTESVLGQN-KYIMLNASSKIKGSKDYEKYETARRLKKK 514

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           IG IR  Y  D+ SK++  +Q A A Y IDKLALRAGNEKD DE ADTVGCC+L+ E++ 
Sbjct: 515 IGGIRERYIADWKSKEMRIRQRATALYFIDKLALRAGNEKDVDESADTVGCCSLRYEHIK 574

Query: 650 REAPNKLK------------FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFD 697
                KL+            F+FLGKDSI+Y N V VE  V+  +  F ++KK GDDLFD
Sbjct: 575 LFESAKLQETDKKEKEFVVEFDFLGKDSIRYFNRVAVEKRVFKNLKLFMENKKAGDDLFD 634

Query: 698 MLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQV 756
            LDT+ LN HL+ LM GLT KVFRT+NASITL + L K T  D +V  KI+ Y  AN+QV
Sbjct: 635 RLDTATLNEHLRSLMDGLTVKVFRTYNASITLQEQLIKLTNPDDNVAAKILSYNRANRQV 694

Query: 757 AIICNHQRSVSKSHDTQMTRLNEKLDEL---------------QAVLKELRTDLDRARXX 801
           AI+CNHQR+VSK  D  M +L +K+  L               +A +KE    L  AR  
Sbjct: 695 AILCNHQRAVSKGFDESMAKLEQKVMSLKRKSFFRLIFQIKDKKAEVKEAEAALKSAR-- 752

Query: 802 XXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPR 861
                            E  +KK  Q   +++K++     K++ K +ALGTSK+NY+DPR
Sbjct: 753 -------------GAEKEKAQKKYDQKKEQLKKLKIQRTDKDENKQIALGTSKLNYIDPR 799

Query: 862 ITVAWCKRHEVPIEKIFNKSLLAKFTWAMDV----DPDFRF 898
           ITVAWCK+ EVP+E++F K+   KF WA+D+    D +F F
Sbjct: 800 ITVAWCKKFEVPLERVFTKTHREKFRWAIDMTMTTDEEFVF 840


>Q8R4U6_MOUSE (tr|Q8R4U6) DNA topoisomerase I OS=Mus musculus GN=Top1mt PE=2 SV=1
          Length = 593

 Score =  453 bits (1166), Expect = e-125,   Method: Compositional matrix adjust.
 Identities = 244/556 (43%), Positives = 335/556 (60%), Gaps = 19/556 (3%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G  F P Y+P    V  LY GKP+ L+   EEVAT Y  M   +   K+ F+
Sbjct: 45  KWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKMLHLECTSKEVFR 104

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF++DWRK +   +  +I +L  CDFT I+                             
Sbjct: 105 RNFFSDWRKEMTPEERRLITHLDKCDFTEIHKHFLERAEARRTLPREQKQKLKEEAEKLQ 164

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + ++DG +EK+GNF+ EPPGLFRGRG+HPKMG LKRR+ P D+VIN  +D+ IPE 
Sbjct: 165 QEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSKIPE- 223

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +WKE+R DNTV WLA W + I    FKYV L  SS  KG+ D +KYE AR LK  
Sbjct: 224 PPAGHQWKEVRSDNTVMWLAAWVEHIQNS-FKYVILNPSSKPKGEMDWQKYEVARRLKGV 282

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IRA Y  D+ S ++ K+Q+AVA Y IDKLALR GNEK++ E ADTVGCC+L+VE++ 
Sbjct: 283 VDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHIR 342

Query: 650 REAP-----NKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
             AP     + ++ +FLGKDSI+Y+N V VE  V+  +  F +DK   DDLFD L TS L
Sbjct: 343 LHAPAGGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDLFDALTTSSL 402

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL++LM GLTAKVFRT+NAS+TL + L   T+  D V  K++ Y  AN+ VA++CNHQ
Sbjct: 403 NKHLQDLMEGLTAKVFRTYNASVTLQEQLRVLTRAEDSVTCKVLAYNRANRAVAVLCNHQ 462

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R+V K+ +  M  L +K++  +A + E + +L +A                  S    ++
Sbjct: 463 RAVPKTFEKSMQTLQKKIETKKAQVAEAQVELQKAETDLRMRGDSKPK-----SFLQKQR 517

Query: 824 KISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLL 883
           ++ +   ++ ++      KE+ K VALGT+K+NYLDPRI++AWCKR  VP+EKI+NK+  
Sbjct: 518 RLLKLEEQLARLCAKATDKEENKQVALGTAKLNYLDPRISIAWCKRFGVPVEKIYNKTQR 577

Query: 884 AKFTWAMD-VDPDFRF 898
            +F WA +    DF F
Sbjct: 578 ERFAWAFNQAGEDFEF 593


>Q6IM78_RAT (tr|Q6IM78) Mitochondrial DNA topoisomerase I OS=Rattus norvegicus
           GN=Top1mt PE=2 SV=1
          Length = 593

 Score =  450 bits (1158), Expect = e-124,   Method: Compositional matrix adjust.
 Identities = 243/563 (43%), Positives = 335/563 (59%), Gaps = 33/563 (5%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G  F P Y+P    V+  Y GKPV L+   EEVAT Y  M   +   K+ F+
Sbjct: 45  KWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLECTTKEVFR 104

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF++DW+K +   +  +I +L  CDF+ I+                             
Sbjct: 105 RNFFSDWQKEMTAEERKLITHLDKCDFSEIHRHFMERAEARRTLPREQKQKLKEEAEKLQ 164

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+DG +EK+GNF+ EPPGLFRGRG+HPKMG LKRR+ P D+VIN  +D+ IPE 
Sbjct: 165 QEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSKIPE- 223

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +WKE+R DNTV WLA W + I    FKY+ L  SS  KG+ D +KYE AR LK  
Sbjct: 224 PPAGHQWKEVRSDNTVMWLAAWVENIQNS-FKYIILNPSSKPKGEMDWQKYEVARRLKGV 282

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IRA Y  D+ S ++ K+Q+AVA Y IDKLALR GNEK++ E ADTVGCC+L+VE+V 
Sbjct: 283 VDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHVR 342

Query: 650 REAP-----NKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
              P     + ++ +FLGKDSI+Y+N V VE  V+  +  F +DK   DDLFD L TS L
Sbjct: 343 LHTPADGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDLFDALTTSSL 402

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQ 763
           N HL++LM GLTAKVFRT+NASITL + L   T+  D +  K++ Y  AN+ VA++CNHQ
Sbjct: 403 NKHLQDLMEGLTAKVFRTYNASITLQEQLRVLTRAEDSLTCKVLAYNRANRAVAVLCNHQ 462

Query: 764 RSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK 823
           R++ K+ +  M  L +K++  +A + E + +L +A                 +  ++  K
Sbjct: 463 RAIPKTFEESMQTLQKKIETKKAQVAEAQVELQKA------------ETDLRMRGDSKSK 510

Query: 824 KISQTNAKIEKMQRDMKT-------KEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
              Q   ++ K++  +         KE+ K VALGT+K+NYLDPRI++AWCKR  VP+EK
Sbjct: 511 SFLQKQQRLLKLEEQLARLCTKATDKEENKQVALGTAKLNYLDPRISIAWCKRFGVPVEK 570

Query: 877 IFNKSLLAKFTWAMD-VDPDFRF 898
           I+NK+   +F WA +    DF F
Sbjct: 571 IYNKTQRERFAWAFNQAGEDFEF 593


>A4S5R8_OSTLU (tr|A4S5R8) Predicted protein OS=Ostreococcus lucimarinus (strain
           CCE9901) GN=OSTLU_17621 PE=3 SV=1
          Length = 491

 Score =  449 bits (1156), Expect = e-124,   Method: Compositional matrix adjust.
 Identities = 238/502 (47%), Positives = 312/502 (62%), Gaps = 26/502 (5%)

Query: 400 MRDTDYMLKDKFKENFWNDWRKLL--GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXX 457
           M+D+DY  K  F +NF + ++  L  G +  I +   CDFT +Y                
Sbjct: 1   MKDSDYATKPVFVKNFMDGFKAALKNGPHAFITDFSKCDFTKMYMHFLAIREKKKEMTSE 60

Query: 458 XXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDI 517
                            WA +DG +EKVGNFRVEPPGLFRGRGEHPKMGK+KRR+ P DI
Sbjct: 61  EKKRIKAQKDIDEEPYTWATIDGRREKVGNFRVEPPGLFRGRGEHPKMGKIKRRVVPEDI 120

Query: 518 VINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSD 577
            INIGKDA +PE P  G  WK + H++T TWLA WND IN K +KYV   A+S++K +SD
Sbjct: 121 TINIGKDAKVPEPP-AGHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESD 179

Query: 578 KEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADT 637
           ++KYEKAR L  YI  IR  Y ++  S+     Q+AVATYL+DKLALRAG EKD+D ADT
Sbjct: 180 QKKYEKARSLHKYIEKIRKDYKRNMMSESKEMAQLAVATYLVDKLALRAGGEKDEDLADT 239

Query: 638 VGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFD 697
           VG CTL+  ++     N ++F+FLGKDSI+Y    +++   Y  + +F + K    D+FD
Sbjct: 240 VGVCTLRAGHIKFMDDNVIEFDFLGKDSIQYLQQHKIDEVAYKCLQRFVQGKGPDVDIFD 299

Query: 698 MLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVG-EKIVVYQHANKQV 756
            +D  K+NAHL+ LMPGLT KVFRT+NASITLD +L KDTK  D   +K   Y  ANK+V
Sbjct: 300 HVDPQKVNAHLQTLMPGLTIKVFRTYNASITLDRLL-KDTKKNDTTLQKKATYDAANKEV 358

Query: 757 AIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNL 816
           AI+CNHQ+ VSK+HD QM +L EK  +L   + E++   D                    
Sbjct: 359 AILCNHQKGVSKAHDAQMEKLAEKKKDLAKQVAEMKKKTD-------------------- 398

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
             +  +KK++    +  K+   M  KE+LKTV+LGTSKINYLDPRIT++WCKRHEVP   
Sbjct: 399 -DKNQKKKLAALKERQSKLAIQMNMKEELKTVSLGTSKINYLDPRITLSWCKRHEVPPNV 457

Query: 877 IFNKSLLAKFTWAMDVDPDFRF 898
           +F K+L+ KF WAMD + +F F
Sbjct: 458 VFTKALIDKFHWAMDCEMEFSF 479


>B6ABX7_9CRYT (tr|B6ABX7) DNA topoisomerase I, putative OS=Cryptosporidium muris
           RN66 GN=CMU_023350 PE=4 SV=1
          Length = 660

 Score =  446 bits (1146), Expect = e-123,   Method: Compositional matrix adjust.
 Identities = 246/618 (39%), Positives = 354/618 (57%), Gaps = 67/618 (10%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYM 406
           P+  +   +W  L HNGV+F PPYQ H+V ++Y GK ++L  + EE+AT +A + DT++ 
Sbjct: 44  PAKDESSIQWDYLEHNGVMFAPPYQAHKVPLIYDGKEIELPNESEEIATYWAQILDTEWS 103

Query: 407 LKDKFKENFWNDWRKLLGKNHVIQ---NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXX 463
            K++F +N    +   + K H++    N   CDF+ I +                     
Sbjct: 104 SKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEEKERKKNMNKEQKEQQK 163

Query: 464 XXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGK 523
                      +A+VD +KEKVGNFR+EPPGLFRGRGEHPK G LK+RI   ++ +N+ +
Sbjct: 164 RIKNESESPYIYALVDWIKEKVGNFRIEPPGLFRGRGEHPKSGMLKKRIFSEEVTLNVAE 223

Query: 524 DAPIP--ECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKY 581
           DAP+P  +  I G  WK++ HD+ VTWLA++ D IN + FKY+FL+ASS  KG SD  KY
Sbjct: 224 DAPVPKVDSSIIGHAWKDVFHDSNVTWLAYYKDSINNQ-FKYIFLSASSGFKGMSDYNKY 282

Query: 582 EKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTVGC 640
           EKAR LK++I  IR  Y K   S DI  +Q+  ATYLID LALR G EKD ++EADTVGC
Sbjct: 283 EKARKLKNFIHAIRDDYNKKMKSNDIIHRQLGTATYLIDFLALRVGGEKDIEEEADTVGC 342

Query: 641 CTLKVENVT-REAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDML 699
           C+L+VE+++  E    +  +FLGKDSI+Y NTV ++   +  ++ F K+K+  +++FD +
Sbjct: 343 CSLRVEHISFNEDSKSITLDFLGKDSIRYFNTVCIDAAAFYNLMLFCKNKEKHENVFDQI 402

Query: 700 DTSKLNAHLKELMPGLTAKVFRTFNASITL------------------------------ 729
           + S LN +LK +MP L+AKVFRTFNASITL                              
Sbjct: 403 NMSSLNQYLKSIMPELSAKVFRTFNASITLERELLKLRSLTNFSNQTTKSNLDLVKNEFG 462

Query: 730 --------DDMLNKDTKD----GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL 777
                   DD+L  +  +     +V + +  Y  AN++VAI+CNHQRS+ K H++ M +L
Sbjct: 463 IKSDDIKQDDLLRSNLNNIVDITNVNDILRFYNDANREVAILCNHQRSIPKQHESSMEKL 522

Query: 778 NEKLDELQAVLKELRTDLDRAR---------------XXXXXXXXXXXXXXXNLS--SEA 820
            ++  ELQ  LK     L   +                              NLS  SE 
Sbjct: 523 LKQQLELQEDLKICEVYLRLLKKNPNKSITLKDLPKLSTETSFNGKPRKFPINLSSNSEI 582

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           ++KK+     K+  ++  +K K+D KTV+L TSK+NY+DPRI+VA+CK++E+PI+K+FN+
Sbjct: 583 IQKKLDSIKTKLSNLELKIKIKDDNKTVSLNTSKLNYMDPRISVAFCKKYELPIDKVFNR 642

Query: 881 SLLAKFTWAMDVDPDFRF 898
           SL  KF WAM    DF F
Sbjct: 643 SLRTKFPWAMYTRSDFSF 660


>O60013_PNECA (tr|O60013) DNA topoisomerase I OS=Pneumocystis carinii PE=2 SV=1
          Length = 763

 Score =  444 bits (1143), Expect = e-122,   Method: Compositional matrix adjust.
 Identities = 223/450 (49%), Positives = 296/450 (65%), Gaps = 9/450 (2%)

Query: 350 GDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMY-AVMRDTDYM 406
           GDG  KW TL HNGV+FPPPY+P    VKM YKG+P+ L  + EEVA  + A++    Y+
Sbjct: 136 GDGTIKWKTLEHNGVLFPPPYEPLPSYVKMKYKGEPISLPPEAEEVAGFFGAILSSEQYV 195

Query: 407 LKDKFKENFWNDWRKLLGKNH---VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXX 463
               F++NF++D+++   K +   + +  + CDFTP++++                    
Sbjct: 196 KNPTFQKNFFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFEKKKEEKKNKSKEEKKKIK 255

Query: 464 XXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGK 523
                      +  +DG KEKVGNFR+EPPGLFRGRG+HPK GKLK R+ P  ++INIGK
Sbjct: 256 EEKDALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDHPKTGKLKTRVVPEQVIINIGK 315

Query: 524 DAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEK 583
           D+ IP  P PG  WKE+RHDNTVTWLA WN+ +N  + KYVFL+A SSLKGQSD +KYEK
Sbjct: 316 DSVIP-SPPPGHNWKEVRHDNTVTWLATWNENVNNNV-KYVFLSAGSSLKGQSDLKKYEK 373

Query: 584 ARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 643
           AR LK YI NIR  Y K+   K +  +Q A A YLID  ALRAGNEK +DEADTVGCC+L
Sbjct: 374 ARELKLYIDNIRKQYRKELEDKLMEVRQRATAMYLIDLFALRAGNEKGEDEADTVGCCSL 433

Query: 644 KVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTS 702
           + E+++   PN + F+FLGKDSI+Y N V+V+  V+  +  F++  K  GD LFD L+TS
Sbjct: 434 RYEHISLSPPNTVVFDFLGKDSIRYYNEVQVDPQVFKNLKIFKRSPKTEGDMLFDRLNTS 493

Query: 703 KLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNH 762
           KLN HL  LMPGL+AKVFRT NAS T+ + L    KD  + +K++ Y  AN+ VAI+CNH
Sbjct: 494 KLNNHLTSLMPGLSAKVFRTHNASYTMSEQLKNTPKDASISDKVLAYNRANRMVAILCNH 553

Query: 763 QRSVSKSHDTQMTRLNEKLDELQAVLKELR 792
           QR++SK+H  QM R+ +K+  L+     LR
Sbjct: 554 QRTISKTHSAQMERIEDKILALKYQKIRLR 583



 Score = 81.6 bits (200), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 42/124 (33%), Positives = 69/124 (55%), Gaps = 9/124 (7%)

Query: 775 TRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEK 834
           +RL + L+++  + +E + + ++ R                ++ E L+ +I + N +I +
Sbjct: 649 SRLEKFLEKINEMKEEFKIENEKGRVESKTR---------GITIETLDLQIKKINERIHQ 699

Query: 835 MQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDP 894
           M+  M  K   KT ALGTSKINY+DPR+T AWC ++ V IE++F K+L   F WA     
Sbjct: 700 MKALMIDKAQNKTTALGTSKINYIDPRLTYAWCAKYGVNIERVFTKTLRETFAWAASTTA 759

Query: 895 DFRF 898
           D+ F
Sbjct: 760 DWEF 763


>B4MU44_DROWI (tr|B4MU44) GK23720 OS=Drosophila willistoni GN=GK23720 PE=4 SV=1
          Length = 638

 Score =  444 bits (1141), Expect = e-122,   Method: Compositional matrix adjust.
 Identities = 245/569 (43%), Positives = 341/569 (59%), Gaps = 38/569 (6%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           DG K W TL H G +F  PY+  P  V+ LY GKP  L+ + EE AT YA M + +    
Sbjct: 76  DGNK-WLTLEHKGPVFTEPYKRLPANVRFLYDGKPFQLSKETEEAATFYAKMLNHECCRN 134

Query: 409 DKFKENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
             F  NF+ D+R  +   +  +I++   C+F  I+ +                       
Sbjct: 135 RIFYRNFFRDFRLTMTARERKIIKDFHKCNFYEIFKFFQAESNKRLAATKEEKLAKRKKN 194

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   + +VDG +E++ NFR+EPPGLFRGRG+HPKMG +KRR++  DI+IN G+D+ 
Sbjct: 195 EAFVNKYGFCLVDGHRERISNFRLEPPGLFRGRGDHPKMGMIKRRVQACDIIINCGRDSK 254

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           IP  P  G+ WKE+RHDNTVTWLA W D +  +  KY+ L + S ++ +SD  KYE AR 
Sbjct: 255 IP-MPPRGQMWKEVRHDNTVTWLASWVDNVQGQS-KYIILNSWSKIRCESDHNKYETARR 312

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           L  +I  IRA Y +++ SKDI  +Q AVA Y IDKLALR GNEK+ D+ADTVGCC+L+VE
Sbjct: 313 LHKFIDKIRATYREEWKSKDIFVRQRAVALYFIDKLALRVGNEKEKDQADTVGCCSLRVE 372

Query: 647 NVT--REAPNK---LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDT 701
           +V   R   +K   + F+FLGKDSI+Y  TVEVE  V+N +  F KDK     +FD L+ 
Sbjct: 373 HVQLHRRLMDKEYVVAFDFLGKDSIRYYKTVEVEPRVFNNLKLFVKDKGKSYYVFDCLNA 432

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDT-KDGDVGEKIVVYQHANKQVAIIC 760
            +LN HLK LM GLT KVFRT+NAS+TL + L++ T ++  V EK++VY  AN+ VAI+C
Sbjct: 433 HELNDHLKNLMIGLTTKVFRTYNASLTLQNQLDELTDEEATVAEKLLVYNRANRAVAILC 492

Query: 761 NHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEA 820
           NHQRS+ K H   M  L +K+      + +L  + +  +                LS  A
Sbjct: 493 NHQRSIPKGHQQIMENLRKKIHNKSNAINDLEAEFNELK------------RSATLSGTA 540

Query: 821 LEKKISQTNAKIEKMQR----------DMKTKEDLKTVALGTSKINYLDPRITVAWCKRH 870
            +KKI++   K  +++R          +   +E+ K VAL TSK+NY+DPRI+VAWCK++
Sbjct: 541 KDKKIAECKGK--QLERLKDQLKKLKLEETNREENKCVALTTSKLNYIDPRISVAWCKKN 598

Query: 871 EVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
            VPIEKIFNK+   KF WA+ + D ++ F
Sbjct: 599 NVPIEKIFNKTQRTKFLWAIHMADENYHF 627


>A7AUT4_BABBO (tr|A7AUT4) DNA topoisomerase OS=Babesia bovis GN=BBOV_II007450
           PE=3 SV=1
          Length = 701

 Score =  442 bits (1136), Expect = e-122,   Method: Compositional matrix adjust.
 Identities = 253/589 (42%), Positives = 344/589 (58%), Gaps = 49/589 (8%)

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           W  L HNG+IF P Y+PH + + +KG+P+ LT D EEVAT +A    T+Y   + ++ NF
Sbjct: 116 WEYLEHNGMIFTPEYKPHGIPIKFKGEPITLTPDLEEVATFWAQSIGTNYEESEIYRRNF 175

Query: 416 WNDWRKLLGKNHVIQ----NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXX 471
           WN +  +  K HVI+     LKDCDF+ I                               
Sbjct: 176 WNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHLDMEREKKKEQKEYYKALKEETAKKEHP 235

Query: 472 XXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECP 531
              +A+VD ++EKVG+ R+EPPGLF+GRG HPK G LK R  P  +V+N+ KDAP+P+  
Sbjct: 236 YC-YALVDWIREKVGSNRMEPPGLFKGRGLHPKQGLLKGRTFPHSVVLNLSKDAPVPKVS 294

Query: 532 I---PGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLK 588
           +    G  W +I HD++VTWLA++ D +N +  KY++ AA S  KG  D  KY KAR LK
Sbjct: 295 MFERQGHGWSDIFHDSSVTWLAYYRDTVNDQT-KYMYPAAQSKFKGLHDFLKYSKARELK 353

Query: 589 DYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 648
            +I  IR  Y     S +I  +Q+  ATYLID LALR G EKD DEADTVGCC+L+VE++
Sbjct: 354 KHIMKIRKDYHGKMRSPEIVDRQLGTATYLIDFLALRVGGEKDADEADTVGCCSLRVEHI 413

Query: 649 TRE-APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAH 707
             +  PN +  +FLGKDSI+Y +TV ++      + +F K KK  +D+FD ++T KLN +
Sbjct: 414 KFDRKPNTITLDFLGKDSIRYFHTVTLDEVACRNLSEFCK-KKPTEDIFDKINTVKLNDY 472

Query: 708 LKELMPGLTAKVFRTFNASITL------------------------DDMLNKDT--KDGD 741
           LK+LM GLTAKVFRT+NASITL                        DD L+K       D
Sbjct: 473 LKDLMTGLTAKVFRTYNASITLCRQLRRLKVRKSLDSSLMLQPGKSDDDLDKPVLVDVTD 532

Query: 742 VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL-------NEKLDELQAVLKELRTD 794
           V E I  Y  AN++VAI+CNHQRS+ K H++ M+++       +E++ ELQA +K L ++
Sbjct: 533 VNELISFYNEANRRVAILCNHQRSIPKQHESSMSKMQAQAELISEEIAELQAYMKYLESN 592

Query: 795 LDR-----ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVA 849
             +     +R                +  EA +KK+     + +     M+ K+D KTVA
Sbjct: 593 QTKPFTFESRTVDAKGNPRKAATRQGMKLEACQKKLETAMKRSKVHAIKMRIKDDNKTVA 652

Query: 850 LGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           LGTSKINY+DPRITVA+CKR+EVPIEKIFNKSL  KF WAM    D+ F
Sbjct: 653 LGTSKINYMDPRITVAFCKRYEVPIEKIFNKSLRTKFPWAMYAGADYIF 701


>Q4SKE8_TETNG (tr|Q4SKE8) Chromosome 13 SCAF14566, whole genome shotgun sequence.
           (Fragment) OS=Tetraodon nigroviridis
           GN=GSTENG00016753001 PE=3 SV=1
          Length = 622

 Score =  441 bits (1134), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 252/587 (42%), Positives = 341/587 (58%), Gaps = 49/587 (8%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H+G  FPP YQP    V   Y GK V L+   EEVA  +A M D +Y  K  F+
Sbjct: 42  KWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEEVALFFAQMLDHEYTTKKVFR 101

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           ENF+ DWRK +   +  +IQ L  CDF  I+                             
Sbjct: 102 ENFFQDWRKEMTDEERSLIQELDKCDFGEIHAMHKAKVEARKNMSKEEKLVCNIQFRKVL 161

Query: 471 XXXX--------WAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIG 522
                       + ++D  +E++GNF++EPPGLFRGRGEHPK GKLK+RI+P D++IN  
Sbjct: 162 KEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGKLKKRIQPEDVIINCS 221

Query: 523 KDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYE 582
           K++ IP  P  G RWKE+RHDNTVTWLA W + I   + KY+ L A+S LKG+ D EKYE
Sbjct: 222 KESRIP-VPPAGHRWKEVRHDNTVTWLASWTENIQGSI-KYIMLNANSKLKGEKDWEKYE 279

Query: 583 KARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDK---------LALRAGNEKDDD 633
            AR LK  + NIR  Y  D  S+++  +Q AVA Y IDK         LALRAGNEK++ 
Sbjct: 280 VARKLKSCVDNIRNQYLMDLKSREMCTRQRAVALYFIDKVGVTVVILKLALRAGNEKEEG 339

Query: 634 E-ADTVGCCTLKVENVTRE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK 687
           E ADTVGCC+L+VE++T       +   ++F+FLGKDSI+Y N V V   V+  +  F +
Sbjct: 340 ETADTVGCCSLRVEHITLHDTLDASECVVEFDFLGKDSIRYYNKVPVIKKVFKNLKLFME 399

Query: 688 DKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDT---------- 737
           DK+ GD+LFD L+TS LN HL  LMPGLTAKVFRT+NASITL   L + T          
Sbjct: 400 DKQPGDELFDRLNTSLLNKHLSSLMPGLTAKVFRTYNASITLQQQLKELTNVIILFFFPC 459

Query: 738 ---KDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTD 794
              +   V EK++ Y  AN+ VAI+CNHQR+  K+ D  M  L  K++  +  L   +++
Sbjct: 460 RLPESDSVAEKLLSYNRANRAVAILCNHQRAPPKTFDQSMANLQSKIEARKEQLVLAKSE 519

Query: 795 LDRARXXXXXXXXXXXXXXXNLSSEALEKKIS--QTNAKIEKMQRDMKTKEDLKTVALGT 852
           L +A                 L +  + KK++  +   ++ K++     +E+ K +ALGT
Sbjct: 520 LKQA----KKEAKAKGSADAKLQALVVRKKMAVKRCEEQLLKLEVQATDREENKQIALGT 575

Query: 853 SKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
           SK+NYLDPRI+VAWCK+ EVP++KI+NKS   KF WA+D+ +  F F
Sbjct: 576 SKLNYLDPRISVAWCKKMEVPVDKIYNKSQRDKFAWAIDMTEVGFEF 622


>Q9Y180_LEIIN (tr|Q9Y180) Topoisomerase I-like protein OS=Leishmania infantum
           PE=3 SV=1
          Length = 635

 Score =  438 bits (1127), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 211/432 (48%), Positives = 283/432 (65%), Gaps = 5/432 (1%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           G+++W TL HNGV+FPP Y+PH + + Y G+   +T ++EEVATM+AVM++ DY   + F
Sbjct: 42  GERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVF 101

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           + NF+  WR++L K  H I+ L+ CDF PIY W                           
Sbjct: 102 RRNFFESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEA 161

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + + DG +E+V NFRVEPPGLFRGRG+HP MGKLK R++P DI INIG+ A +P  
Sbjct: 162 EPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVP-V 220

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +W  ++HD+TVTWLA W D +   + KYV LA SSS+KGQSD  K+EKAR LKD 
Sbjct: 221 PPAGHKWAAVQHDHTVTWLAMWRDSVAGNM-KYVMLAPSSSVKGQSDMVKFEKARKLKDK 279

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           + +IRA+Y +DF S D+   Q AVA Y ID+LALR GNEK +DEADTVGCC+L+VE++  
Sbjct: 280 VDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQL 339

Query: 651 EAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKE 710
              N ++F+FLGKDSI+Y+N V V   VY  + +F + K  G D+FD L+ ++LN HLK 
Sbjct: 340 MPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDIFDQLNPTQLNDHLKS 399

Query: 711 LMPGLTAKVFRTFNASITLDDMLNKDTKD--GDVGEKIVVYQHANKQVAIICNHQRSVSK 768
            M GL+AKVFRT+NASITLD    +   D      +K+  +  AN +VAI+CNHQ+SVSK
Sbjct: 400 FMDGLSAKVFRTYNASITLDRWFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSK 459

Query: 769 SHDTQMTRLNEK 780
           +   QM +L  K
Sbjct: 460 NFKLQMMQLTTK 471


>Q9GPZ9_LEIIN (tr|Q9GPZ9) DNA topoisomerase I (DNA topoisomerase IB, large
           subunit) OS=Leishmania infantum GN=LinJ34.2960 PE=1 SV=1
          Length = 635

 Score =  438 bits (1127), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 211/432 (48%), Positives = 283/432 (65%), Gaps = 5/432 (1%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           G+++W TL HNGV+FPP Y+PH + + Y G+   +T ++EEVATM+AVM++ DY   + F
Sbjct: 42  GERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVF 101

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           + NF+  WR++L K  H I+ L+ CDF PIY W                           
Sbjct: 102 RRNFFESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEA 161

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + + DG +E+V NFRVEPPGLFRGRG+HP MGKLK R++P DI INIG+ A +P  
Sbjct: 162 EPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVP-V 220

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +W  ++HD+TVTWLA W D +   + KYV LA SSS+KGQSD  K+EKAR LKD 
Sbjct: 221 PPAGHKWAAVQHDHTVTWLAMWRDSVAGNM-KYVMLAPSSSVKGQSDMVKFEKARKLKDK 279

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           + +IRA+Y +DF S D+   Q AVA Y ID+LALR GNEK +DEADTVGCC+L+VE++  
Sbjct: 280 VDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQL 339

Query: 651 EAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKE 710
              N ++F+FLGKDSI+Y+N V V   VY  + +F + K  G D+FD L+ ++LN HLK 
Sbjct: 340 MPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDIFDQLNPTQLNDHLKS 399

Query: 711 LMPGLTAKVFRTFNASITLDDMLNKDTKD--GDVGEKIVVYQHANKQVAIICNHQRSVSK 768
            M GL+AKVFRT+NASITLD    +   D      +K+  +  AN +VAI+CNHQ+SVSK
Sbjct: 400 FMDGLSAKVFRTYNASITLDRWFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSK 459

Query: 769 SHDTQMTRLNEK 780
           +   QM +L  K
Sbjct: 460 NFKLQMMQLTTK 471


>B5Y3I3_PHATR (tr|B5Y3I3) Predicted protein OS=Phaeodactylum tricornutum CCAP
           1055/1 GN=PHATR_13384 PE=4 SV=1
          Length = 594

 Score =  438 bits (1126), Expect = e-120,   Method: Compositional matrix adjust.
 Identities = 251/573 (43%), Positives = 349/573 (60%), Gaps = 32/573 (5%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDK---- 410
           +W T+ H+GV FP  Y+PH VKM+Y G+PV+LT  QEE AT +A M      L +     
Sbjct: 17  QWRTMEHSGVSFPETYEPHGVKMMYDGQPVELTPIQEEAATFFAAMDPEGMHLGNPKTGK 76

Query: 411 -FKENFWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXX 469
            F +NF+ D+R++LGK H+++  K CDF PI                             
Sbjct: 77  IFIKNFFADFREILGKKHIVKEFKKCDFEPIRKHLNEQKIIRKAITDEERKANKEDRSQT 136

Query: 470 XXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPE 529
                ++IVDG  E+VGNF +EPPG FRGRGEHPKMGKLK R+ P  + +N+ + AP+P 
Sbjct: 137 LHQFGFSIVDGHIERVGNFNMEPPGAFRGRGEHPKMGKLKSRVLPEQVSLNLSECAPVPP 196

Query: 530 CPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
           CP+PG  W ++RHD    WLA W + IN +  KY+ LAA SS KG+SD+ KY KA +L  
Sbjct: 197 CPVPGHAWSDVRHDPRGQWLATWKENINNQS-KYMQLAAQSSFKGKSDRSKYSKAGLLCK 255

Query: 590 YIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTVGCCTLKVENV 648
            I  IR +Y KD  SKD+  +Q+A AT++ID+LALR G EKD D+EADTVGCC+L+VE++
Sbjct: 256 NIEKIRKSYKKDLKSKDMEVKQLATATWVIDRLALRVGGEKDTDEEADTVGCCSLRVEHL 315

Query: 649 TREAPN-------KLKFNFLGKDSIKYENTVEVELPVYN-----------AILKFQKDKK 690
             + PN       +++  FLGKDS+ ++ T++    +YN            +  F K KK
Sbjct: 316 HFD-PNGEGGDSKEIELEFLGKDSMLFKQTIDFGATLYNDSNGLGAQVYDNLKSFCKKKK 374

Query: 691 GGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK-----DTKDGDVGEK 745
             +++F +++ + LN HLK+ M GL+AKVFRT+NAS TL   L K       ++    EK
Sbjct: 375 SSEEVFHVINPTMLNNHLKQFMDGLSAKVFRTYNASKTLQTELRKYEVSPAWRNLTASEK 434

Query: 746 IVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXX 805
           +V Y +AN++VAI+CNHQRSVSK+ +TQ+  +  K+  +    K+    + +        
Sbjct: 435 VVEYNNANREVAILCNHQRSVSKAQETQLENITAKVG-MLKKQKKDLKKILKLLTAGEAD 493

Query: 806 XXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVA 865
                     ++ E + KKI   N KI KM+ D+K K+D K V+LGTSKINY+DPRI+VA
Sbjct: 494 KIPTKKSPQTMTDEQVVKKIEAWNGKISKMEMDLKHKDDNKEVSLGTSKINYMDPRISVA 553

Query: 866 WCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           WCKR+EVPIEKIF+K+L  KF WAM V PD+ F
Sbjct: 554 WCKRNEVPIEKIFSKTLRDKFNWAMAVVPDWEF 586


>A4HB62_LEIBR (tr|A4HB62) DNA topoisomerase IB, large subunit OS=Leishmania
           braziliensis GN=LbrM20_V2.3020 PE=3 SV=1
          Length = 637

 Score =  437 bits (1124), Expect = e-120,   Method: Compositional matrix adjust.
 Identities = 209/432 (48%), Positives = 284/432 (65%), Gaps = 5/432 (1%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           G+++W TL HNGV+FPP Y+PH + + Y G+   +T ++EEVATM+AVM++ DY   + F
Sbjct: 42  GERRWETLSHNGVLFPPEYEPHGISIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEAF 101

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           + NF+  WR++L K  H I+ L+ CDF PIY W                           
Sbjct: 102 RRNFFESWREILDKRQHPIRRLELCDFEPIYQWYLAEREKKLNRTKEEKKSIKEKQDMDA 161

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + + DG +E+V NFRVEPPGLFRGRG+HP MGKLK R++P  I INIG+ A +P  
Sbjct: 162 EPYRYCMWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKARVQPEGITINIGETAEVP-V 220

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +W  ++HD+TVTWLA W D +     KYV LAASSS+KGQSD  K+EKAR LKD 
Sbjct: 221 PPAGHKWGAVQHDHTVTWLAMWRDSVVGNA-KYVMLAASSSVKGQSDMMKFEKARKLKDK 279

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           + +IRA+Y +DF S D+   Q AVA Y ID+LALR GNEK +DEADTVGCC+L+VE++  
Sbjct: 280 VDDIRASYMEDFKSNDVHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQL 339

Query: 651 EAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKE 710
            + N ++F+FLGKDSI+Y+N V V   VY  + +F + K  G D+FD L+ ++LN HLK 
Sbjct: 340 MSDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGTDIFDQLNPTQLNDHLKS 399

Query: 711 LMPGLTAKVFRTFNASITLDDMLNKDTKDG--DVGEKIVVYQHANKQVAIICNHQRSVSK 768
            M GL+AKVFRT+NASITLD    +   D    + +K+  +  AN +VAI+CNHQ+++SK
Sbjct: 400 FMNGLSAKVFRTYNASITLDRWFKEKPVDSKWSIADKLAYFNKANTEVAILCNHQKAISK 459

Query: 769 SHDTQMTRLNEK 780
           +   QM +L  K
Sbjct: 460 NFKLQMMQLTTK 471


>Q4Q2K0_LEIMA (tr|Q4Q2K0) DNA topoisomerase IB, large subunit OS=Leishmania major
           GN=LmjF34.3440 PE=3 SV=1
          Length = 634

 Score =  437 bits (1124), Expect = e-120,   Method: Compositional matrix adjust.
 Identities = 213/443 (48%), Positives = 287/443 (64%), Gaps = 5/443 (1%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           G+++W TL HNGV+FPP Y+PH + + Y G+   +T ++EEVATM+AVM++ DY   + F
Sbjct: 42  GERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVF 101

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           + NF+  WR++LGK  H I+ L+ CDF PIY W                           
Sbjct: 102 RRNFFESWREILGKRQHPIRRLELCDFEPIYQWYLVQREKKLSRTKEEKKAIKEKQDAEA 161

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + + DG +E+V NFRVEPPGLFRGRG+HP MGKLK R++P DI INIG+ A +P  
Sbjct: 162 EPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVP-V 220

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +W  ++HD+TVTWLA W D +   + KYV LA SSS+KGQSD  K+EKAR LKD 
Sbjct: 221 PPAGHKWAAVQHDHTVTWLAMWRDNVAGNM-KYVMLAPSSSVKGQSDMVKFEKARKLKDK 279

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           + +IRA+Y + F S D+   Q AVA Y ID+LALR GNEK +DEADTVGCC+L+VE++  
Sbjct: 280 VDDIRASYMEAFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQL 339

Query: 651 EAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKE 710
              N ++F+FLGKDSI+Y+N V V   VY  + +F   K  G D+FD L+ ++LN HLK 
Sbjct: 340 MPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTCRKSPGMDIFDQLNPTQLNDHLKS 399

Query: 711 LMPGLTAKVFRTFNASITLDDMLNKDTKD--GDVGEKIVVYQHANKQVAIICNHQRSVSK 768
            M GL+AKVFRT+NASITLD    +   D      +K+  +  AN +VAI+CNHQ+SVSK
Sbjct: 400 FMDGLSAKVFRTYNASITLDRWFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSK 459

Query: 769 SHDTQMTRLNEKLDELQAVLKEL 791
           +   QM +L  K +  +  L+ L
Sbjct: 460 NFKLQMMQLTTKSEYTRKTLELL 482


>Q5KB99_CRYNE (tr|Q5KB99) Topoisomerase I (Putative uncharacterized protein)
           OS=Cryptococcus neoformans GN=CNBH3140 PE=3 SV=1
          Length = 881

 Score =  436 bits (1120), Expect = e-120,   Method: Compositional matrix adjust.
 Identities = 222/454 (48%), Positives = 288/454 (63%), Gaps = 10/454 (2%)

Query: 350 GDGQKKWTTLVHNGVIFPPPY--QPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYML 407
           GDG  KWT L HN V+FPPPY   P  VKM Y G  + L  + EEVA  +  + +TDY  
Sbjct: 253 GDGSSKWTVLEHNAVLFPPPYVPLPKNVKMKYDGVSLTLPPESEEVAGFFGALLETDYAQ 312

Query: 408 KDKFKENFWNDWRKLLGK-----NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXX 462
             KF+ENF+ D++ ++ K     +  ++ L+ CDF P++++                   
Sbjct: 313 DAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKALTKEEKKAI 372

Query: 463 XXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIG 522
                       +A VDG KEKVGNFR EPPGLF+GRGEHPK G +K R+RP DI+INIG
Sbjct: 373 KAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIIINIG 432

Query: 523 KDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYE 582
           K+APIP   IPG+ WK I+HDNTVTWLA W + +N    KYVFL+A S+ KGQSD+ K+E
Sbjct: 433 KEAPIPVPNIPGQ-WKGIQHDNTVTWLAHWKENVNGNA-KYVFLSAGSAWKGQSDRAKFE 490

Query: 583 KARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 642
           KAR L  ++  IR  YT D  SK +  +Q A A Y ID+LALRAGNEK +DEADTVGCC+
Sbjct: 491 KARELIKHVDKIRKDYTADLKSKVMADRQRATALYFIDRLALRAGNEKGEDEADTVGCCS 550

Query: 643 LKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDT 701
           L+ E+VT   PN + F+FLGKDS+++   VEV+  V+  I  F+ D KK GDD+FD L T
Sbjct: 551 LRYEHVTLSPPNTIIFDFLGKDSMRFHQEVEVDPQVFKNIKLFKADPKKKGDDIFDRLTT 610

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICN 761
           + LN HL  +MPGLTAKVFRT+NAS T  + L    K+G V EKI  Y  AN+ VAI+CN
Sbjct: 611 TLLNKHLNSMMPGLTAKVFRTYNASWTFQEQLKNTPKNGTVAEKIAAYNTANRDVAILCN 670

Query: 762 HQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDL 795
           HQ+SVSK  +    +  +K+  L+    +LR  L
Sbjct: 671 HQKSVSKGFEGSFAKAEDKIRALKYQRLKLRLQL 704



 Score = 85.5 bits (210), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 45/123 (36%), Positives = 73/123 (59%), Gaps = 11/123 (8%)

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L+E+L E++A  KEL+ +                      + E L  ++++ + +I   +
Sbjct: 769 LDERLSEIKAEFKELKKE----------RKAKKIDAKRGATEEKLLAQVARIDERIATAK 818

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA-MDVDPD 895
             ++ ++ LK VALGTSKINY+DPR+TVAW K+ +VP+EK+F+K+L  KF WA  +  PD
Sbjct: 819 VQLQDRDKLKDVALGTSKINYIDPRLTVAWAKKFDVPLEKLFSKTLREKFPWAEAEAGPD 878

Query: 896 FRF 898
           + F
Sbjct: 879 WVF 881


>A8N6Y9_COPC7 (tr|A8N6Y9) Putative uncharacterized protein OS=Coprinopsis cinerea
           (strain Okayama-7 / 130 / FGSC 9003) GN=CC1G_06861 PE=3
           SV=1
          Length = 863

 Score =  433 bits (1114), Expect = e-119,   Method: Compositional matrix adjust.
 Identities = 221/440 (50%), Positives = 284/440 (64%), Gaps = 10/440 (2%)

Query: 349 SGDGQKKWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYM 406
           +GDG +KW TL HNGV FPPPY+  P  VKM Y GK VDL+ + EEVA  Y  + +TD+ 
Sbjct: 251 NGDGTQKWETLEHNGVYFPPPYEALPKHVKMKYNGKDVDLSIEAEEVAGFYGALLETDHA 310

Query: 407 LKDKFKENFWNDWRKLLGK-----NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
               F +NF+ D++K+L K        I   + CDF P++++                  
Sbjct: 311 KDATFNKNFFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAEKAKRKAMTNEEKKA 370

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                          ++DG KEKVGNFR+EPPGLFRGRGEHPK G LK+R+ P DI INI
Sbjct: 371 AKKKKDELEEKYKTCVMDGRKEKVGNFRIEPPGLFRGRGEHPKKGSLKKRVYPEDITINI 430

Query: 522 GKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKY 581
           GK+A IP   IPG +WK++ HDNTVTWLA W + IN    KYVFLAA S LKGQSD +K+
Sbjct: 431 GKEAKIPVPNIPG-KWKKVIHDNTVTWLATWTENIN-NSHKYVFLAAGSRLKGQSDMQKF 488

Query: 582 EKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCC 641
           EKAR LKD+I  IRA YT+D  +K +  +Q A A Y IDKLALRAGNEK +DEADTVGCC
Sbjct: 489 EKARELKDHIEKIRADYTEDLRNKVMAHRQRATAMYFIDKLALRAGNEKGEDEADTVGCC 548

Query: 642 TLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDT 701
           +L+ E+VT   PN++ F+FLGKDSI+Y   V V+  V+  I  F++ K+  D+LFD + T
Sbjct: 549 SLRCEHVTLRPPNEIVFDFLGKDSIRYFKEVPVDAQVFKNIRIFKEGKELEDNLFDRVTT 608

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLN-KDTKDGDVGEKIVVYQHANKQVAIIC 760
           + LN HL   M GLTAKVFRT+NAS T   +L+ +D  +  + EKI  Y  AN+ VAI+C
Sbjct: 609 AGLNKHLTSYMKGLTAKVFRTYNASSTFQRLLDEEDLTNATIQEKINAYNKANRMVAILC 668

Query: 761 NHQRSVSKSHDTQMTRLNEK 780
           NHQR+  K+HD  M ++  K
Sbjct: 669 NHQRAAPKTHDQSMEKMRYK 688



 Score = 93.2 bits (230), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 44/81 (54%), Positives = 61/81 (75%)

Query: 818 SEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKI 877
           +E LE+ I + + +I+  +  M  +++ K VALGTSKINYLDPRITVAW   ++VPIEK+
Sbjct: 783 TEKLEEMIEKLDDRIKTFKLQMIDRDEGKEVALGTSKINYLDPRITVAWASANKVPIEKM 842

Query: 878 FNKSLLAKFTWAMDVDPDFRF 898
           F+K+LL KF WAM VD D++F
Sbjct: 843 FSKTLLEKFPWAMGVDDDWKF 863


>O59891_CRYNE (tr|O59891) Topoisomerase I OS=Cryptococcus neoformans var.
           neoformans GN=Topo I PE=3 SV=1
          Length = 844

 Score =  431 bits (1109), Expect = e-119,   Method: Compositional matrix adjust.
 Identities = 221/454 (48%), Positives = 287/454 (63%), Gaps = 10/454 (2%)

Query: 350 GDGQKKWTTLVHNGVIFPPPY--QPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYML 407
           GDG  KWT L HN V+FPPPY   P  VKM Y G  + L  + EEVA  +  + +TDY  
Sbjct: 216 GDGSSKWTVLEHNAVLFPPPYVPLPKDVKMKYDGVSLTLPPESEEVAGFFGALLETDYAQ 275

Query: 408 KDKFKENFWNDWRKLLGK-----NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXX 462
             KF+ENF+ D++ ++ K     +  ++ L+ CDF P++++                   
Sbjct: 276 DAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKALTKEEKKAI 335

Query: 463 XXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIG 522
                       +A VDG KEKVGNFR EPPGLF+GRGEHPK G +K R+RP DI+INIG
Sbjct: 336 KAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIIINIG 395

Query: 523 KDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYE 582
           K+APIP   IPG+ WK I+HDNTVTWLA W + +N    KYVFL+A S+ KGQSD+ K+E
Sbjct: 396 KEAPIPVPNIPGQ-WKGIQHDNTVTWLAHWKENVNGNA-KYVFLSAGSAWKGQSDRAKFE 453

Query: 583 KARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 642
           KAR L  ++  IR  YT D  SK +  +Q A A Y ID+LALRAGNEK +DEADTVGCC+
Sbjct: 454 KARELIKHVDKIRKDYTADLKSKIMADRQRATALYFIDRLALRAGNEKGEDEADTVGCCS 513

Query: 643 LKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDT 701
           L+ E+VT   PN + F+FLGKDS+++   VEV+  V+  I  F+ D KK GDD+FD L T
Sbjct: 514 LRYEHVTLSPPNTIIFDFLGKDSMRFHQEVEVDPQVFKNIKLFKADPKKKGDDIFDRLTT 573

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICN 761
           + LN HL  +MPGLTAKVFRT+NAS T  + L     +G V EKI  Y  AN+ VAI+CN
Sbjct: 574 TLLNKHLNGMMPGLTAKVFRTYNASWTFQEQLKNTPTNGTVAEKIAAYNTANRDVAILCN 633

Query: 762 HQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDL 795
           HQ+SVSK  +    +  +K+  L+    +LR  L
Sbjct: 634 HQKSVSKGFEGSFAKAEDKIRALKYQRLKLRLQL 667



 Score = 85.5 bits (210), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 46/123 (37%), Positives = 73/123 (59%), Gaps = 11/123 (8%)

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L+E+L E++A  KEL+ +                      + E L  +I++ + +I   +
Sbjct: 732 LDERLSEIKAEFKELKKE----------RKAKKIDPKRGATEEKLLAQIARIDERIATAK 781

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA-MDVDPD 895
             ++ ++ LK VALGTSKINY+DPR+TVAW K+ +VP+EK+F+K+L  KF WA  +  PD
Sbjct: 782 VQLQDRDKLKDVALGTSKINYIDPRLTVAWAKKFDVPLEKLFSKTLREKFPWAEAEAGPD 841

Query: 896 FRF 898
           + F
Sbjct: 842 WVF 844


>Q9NJG8_LEIDO (tr|Q9NJG8) DNA topoisomerase I OS=Leishmania donovani donovani
           GN=TOP1 PE=3 SV=1
          Length = 949

 Score =  429 bits (1103), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 211/432 (48%), Positives = 283/432 (65%), Gaps = 6/432 (1%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           G+++W TL HNGV+FPP Y+PH + + Y G+   +T ++EEVATM+AVM++ DY   + F
Sbjct: 357 GERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVF 416

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           + NF+  WR++L K  H I+ L+ CDF PIY W                           
Sbjct: 417 RRNFFESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEA 476

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + + DG +E+V NFRVEPPGLFRGRG+HP MGKLK R++P DI INIG+ A +P  
Sbjct: 477 EPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVP-V 535

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P  G +W  ++HD+TVTWLA W D +   + KYV LA SSS+KGQSD  K+EKAR LKD 
Sbjct: 536 PPAGHKWAAVQHDHTVTWLAMWRDSVAGNM-KYVMLAPSSSVKGQSDMVKFEKARKLKDK 594

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           + +IRA+Y +DF S D+   Q AVA Y ID+LALR GNEK +DEADTVGCC+L+VE++  
Sbjct: 595 VDDIRASYMEDFKSNDLHVAQRAVAMY-IDRLALRVGNEKGEDEADTVGCCSLRVEHIQL 653

Query: 651 EAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKE 710
              N ++F+FLGKDSI+Y+N V V   VY  + +F + K  G D+FD L+ ++LN HLK 
Sbjct: 654 MPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDIFDQLNPTQLNDHLKS 713

Query: 711 LMPGLTAKVFRTFNASITLDDMLNKDTKD--GDVGEKIVVYQHANKQVAIICNHQRSVSK 768
            M GL+AKVFRT+NASITLD    +   D      +K+  +  AN +VAI+CNHQ+SVSK
Sbjct: 714 FMDGLSAKVFRTYNASITLDRWFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSK 773

Query: 769 SHDTQMTRLNEK 780
           +   QM +L  K
Sbjct: 774 NFKLQMMQLTTK 785


>A2Q8K2_ASPNC (tr|A2Q8K2) Catalytic activity: ATP-independent breakage of
           single-stranded DNA OS=Aspergillus niger (strain CBS
           513.88 / FGSC A1513) GN=An01g04640 PE=3 SV=1
          Length = 884

 Score =  429 bits (1102), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 219/453 (48%), Positives = 292/453 (64%), Gaps = 16/453 (3%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PV L  D EEVA  +  M + T
Sbjct: 245 PTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGIPVTLHPDAEEVAGFFGGMLNAT 304

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
            ++    F++NF+ D+R +L K         N V I++   CDF PI+ +          
Sbjct: 305 QHVENPTFQKNFFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQPIFAYYDNQRQEKKA 364

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 365 LPPAEKKRLKAEKDAQEAPYMFCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKSRVQ 424

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDAP+P  P  G +WKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 425 PEQITINIGKDAPVPPPP-EGHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 482

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +IG IR  Y K+   + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 483 GQSDYKKFEKARELKHHIGRIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGED 542

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 543 EAETVGCCSLKYENVTLKPPNKVVFDFLGKDSIRFYDEVEVDAQVFKNLKIFKKAPKKEG 602

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   M GLTAKVFRT+NAS T+  +L      G++ EK+  Y  A
Sbjct: 603 DEIFDRLTTSALNKHLSAYMQGLTAKVFRTYNASHTMSTLLKDMKATGNIAEKVKAYNDA 662

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           N++VAI+CNH+R+V+ SH  QM +++E++  L+
Sbjct: 663 NRKVAILCNHKRTVAASHANQMEKMSERIKGLR 695



 Score = 83.2 bits (204), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 41/79 (51%), Positives = 56/79 (70%), Gaps = 1/79 (1%)

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           +E  I++   +IE M+   + KE+ K VALGTSKINY+DPR+TV + K+ +VPIEK F+K
Sbjct: 806 IEAAITKLEQRIETMELQAQDKEENKEVALGTSKINYIDPRLTVVFSKKFDVPIEKFFSK 865

Query: 881 SLLAKFTWAM-DVDPDFRF 898
           SL  KF WA+  VD D+ F
Sbjct: 866 SLREKFEWAIKSVDEDWEF 884


>Q6FNH4_CANGA (tr|Q6FNH4) Similar to uniprot|P04786 Saccharomyces cerevisiae
           YOL006c TOP1 DNA topoisomerase I OS=Candida glabrata
           GN=CAGL0J11660g PE=3 SV=1
          Length = 744

 Score =  428 bits (1100), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 221/439 (50%), Positives = 285/439 (64%), Gaps = 11/439 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW +L HNGV+FPP Y+P    VK+ Y GKPVDL    EEVA  +A +  TD+     F+
Sbjct: 119 KWVSLKHNGVLFPPEYEPLPSHVKLYYDGKPVDLPPAAEEVAGFFANLLHTDHAKNPVFQ 178

Query: 413 ENFWNDWRKLLGKNHVIQN------LKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
           +NF+ D+ ++L ++   +N       K CDF+ +  +                       
Sbjct: 179 KNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFELKKEEKRNMSREEKKQIKLEK 238

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   +  +DG KE+VGNFRVEPP LFRGRG HPK GKLKRR+ P DI++N+ KDAP
Sbjct: 239 DKFEEKFKFCELDGRKEQVGNFRVEPPDLFRGRGAHPKTGKLKRRVYPEDIILNLSKDAP 298

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           IP  P  G  W EIRHDNTV WLA W + I    FKYV LAA+SSL GQSD +K+EKAR 
Sbjct: 299 IPPAP-QGHHWGEIRHDNTVQWLAMWKENIFGS-FKYVRLAANSSLNGQSDLKKFEKARE 356

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LK YIG+IR  Y + F SK + ++Q AVATY ID  ALRAG EK +DEADTVGCC+L+ E
Sbjct: 357 LKKYIGDIRKDYRESFKSKIMLERQKAVATYFIDVFALRAGGEKSEDEADTVGCCSLRFE 416

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSKLN 705
           +VT + PN + F+FLGKDSI+Y   VEVE  V+  +  F++  KK GDDLFD LD S LN
Sbjct: 417 HVTLKPPNTVIFDFLGKDSIRYHQEVEVEKQVFKNLKIFKRPPKKDGDDLFDRLDPSILN 476

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
            +L+  MPGLTAKVFRT+NAS T+ D L+    +G V EK++ Y  AN+ VAI+CNHQRS
Sbjct: 477 KYLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNEGTVAEKLLKYNAANRAVAILCNHQRS 536

Query: 766 VSKSHDTQMTRLNEKLDEL 784
           V+K H   + ++N+K++EL
Sbjct: 537 VTKGHAQSVEKMNQKIEEL 555



 Score = 84.0 bits (206), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 40/83 (48%), Positives = 59/83 (71%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E LEK++ +   +I+     +K KE+   V+LGTSKINY+DPR++V +CK++ VPIEK
Sbjct: 662 SVEKLEKQVEKLEERIKTSSIQLKDKEENSQVSLGTSKINYIDPRLSVVFCKKYNVPIEK 721

Query: 877 IFNKSLLAKFTWAMD-VDPDFRF 898
           IF K+L  KF WA++  D ++RF
Sbjct: 722 IFTKTLREKFAWAIESADENWRF 744


>Q0CUT4_ASPTN (tr|Q0CUT4) DNA topoisomerase I OS=Aspergillus terreus (strain NIH
           2624) GN=ATEG_02550 PE=3 SV=1
          Length = 872

 Score =  428 bits (1100), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 223/467 (47%), Positives = 297/467 (63%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+  DG  KWTTL HNGV+FPPPY+P    VKM Y G PV L  D EEVA  +  M + T
Sbjct: 233 PTKSDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPVTLHPDAEEVAGFFGSMLNST 292

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
            +     F++NF+ D++ +L K         N V I+  K CDF PI+D+          
Sbjct: 293 QHTENPTFQKNFFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIFDYYEAKRIEKRN 352

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 353 LPAAEKKRLKAEKDEQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQ 412

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK+A +P  P  G +WKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 413 PEQITINIGKEARVPPPP-EGHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 470

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK YIG IR  Y K+   + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 471 GQSDYKKFEKARELKKYIGKIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGED 530

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + V+V+  V+  +  F+K  KK G
Sbjct: 531 EAETVGCCSLKYENVTLKPPNKVVFDFLGKDSIRFYDEVDVDPQVFKNLKIFKKAPKKEG 590

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   MPGLTAKVFRT+NAS T+ ++L      G++ EK+  Y  A
Sbjct: 591 DEIFDRLTTSALNKHLSNYMPGLTAKVFRTYNASHTMAELLKDMKATGNIAEKVKAYNDA 650

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V  SH  QM +++E++  L+     LK+   DLD
Sbjct: 651 NRRVAILCNHKRTVGASHANQMEKMSERIKGLRYQRWRLKQQMLDLD 697



 Score = 83.6 bits (205), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 42/81 (51%), Positives = 55/81 (67%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E +E  I +   +IE M+   + KED K VALGTSKINY+DPR+TV + K+  VPIEK F
Sbjct: 792 EKIEANIQKLEQRIETMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFNVPIEKFF 851

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +K+L  KF WA+  VD D+ F
Sbjct: 852 SKALREKFEWAIKSVDEDWEF 872


>Q2URN8_ASPOR (tr|Q2URN8) DNA topoisomerase I OS=Aspergillus oryzae
           GN=AO090005000750 PE=3 SV=1
          Length = 881

 Score =  427 bits (1098), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 219/453 (48%), Positives = 291/453 (64%), Gaps = 16/453 (3%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PV+L  D EEVA  +  M + T
Sbjct: 242 PTKGDGTIKWTTLEHNGVVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNAT 301

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
            ++    F++NF+ D++ +L K         N V I++   CDF PI+ +          
Sbjct: 302 QHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYDMKRLEKKN 361

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 362 LPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKSRVQ 421

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDAP+P  P  G RWKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 422 PEQITINIGKDAPVPPPP-EGHRWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 479

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K+  ++ + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 480 GQSDYKKFEKARELKKHIDKIRKDYKKNMKNELMVERQKATAVYLIDQFALRAGNEKGED 539

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 540 EAETVGCCSLKYENVTLKPPNKVVFDFLGKDSIRFYDEVEVDAQVFKNLKIFKKSPKKEG 599

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   M GLTAKVFRT+NAS T+  +L      G + EK+  Y  A
Sbjct: 600 DEIFDRLTTSALNKHLSNYMQGLTAKVFRTYNASHTMSTLLKDMKATGTIAEKVKAYNDA 659

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           N+QVAI+CNH+R+V+ SH  QM ++ E++  L+
Sbjct: 660 NRQVAILCNHKRTVTASHANQMEKMGERIKGLR 692



 Score = 84.0 bits (206), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 43/81 (53%), Positives = 55/81 (67%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  I +   +IE M+   + KED K VALGTSKINY+DPR+TV + K+  VPIEK F
Sbjct: 801 EKLENAIQKLEQRIETMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFNVPIEKFF 860

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +KSL  KF WA+  V+ D+ F
Sbjct: 861 SKSLREKFEWAIKSVEQDWEF 881


>A1D4R5_NEOFI (tr|A1D4R5) Topoisomerase I OS=Neosartorya fischeri (strain ATCC
           1020 / DSM 3700 / NRRL 181) GN=NFIA_021160 PE=3 SV=1
          Length = 886

 Score =  427 bits (1097), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 222/467 (47%), Positives = 294/467 (62%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PV L  + EEVA  +  M + T
Sbjct: 247 PTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHPEAEEVAGFFGSMLNAT 306

Query: 404 DYMLKDKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
            ++    F++NF+ D++++L          G    I+    CDF PI+D+          
Sbjct: 307 QHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYEAKRIEKKN 366

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 367 LPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQ 426

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDAP+P  P  G RWKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 427 PEQITINIGKDAPVPPPP-EGHRWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 484

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           G SD +K+EKAR LK +I  IR  Y K    + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 485 GLSDYKKFEKARELKKHIDRIRKDYQKALKHELMVERQKATAVYLIDQFALRAGNEKGED 544

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 545 EAETVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKKEG 604

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   MPGLTAKVFRT+NAS T+  +L      G V EK+  Y  A
Sbjct: 605 DEIFDRLTTSALNKHLSNYMPGLTAKVFRTYNASYTMATLLKDMKATGSVAEKVKAYNDA 664

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V+ SH  QM +++E++  L+     LK+   DLD
Sbjct: 665 NRRVAILCNHKRTVTASHANQMEKMSERIKGLRYQRWRLKQQMLDLD 711



 Score = 83.6 bits (205), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 43/83 (51%), Positives = 57/83 (68%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E LE  I++   +IE M+   + KE+ K VALGTSKINY+DPR+TV + K+  VPIEK
Sbjct: 804 SVEKLEAAITKLEQRIETMELQAQDKEENKEVALGTSKINYIDPRLTVVFSKKFNVPIEK 863

Query: 877 IFNKSLLAKFTWAM-DVDPDFRF 898
            F+KSL  KF WA+  VD ++ F
Sbjct: 864 FFSKSLREKFEWAIKSVDENWEF 886


>Q4WK70_ASPFU (tr|Q4WK70) Topoisomerase I OS=Aspergillus fumigatus
           GN=AFUA_1G03500 PE=3 SV=1
          Length = 998

 Score =  427 bits (1097), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 222/467 (47%), Positives = 294/467 (62%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PV L  + EEVA  +  M + T
Sbjct: 359 PTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHPEAEEVAGFFGSMLNAT 418

Query: 404 DYMLKDKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
            ++    F++NF+ D++++L          G    I+    CDF PI+D+          
Sbjct: 419 QHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYDAKRIEKKN 478

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 479 LPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQ 538

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDAP+P  P  G RWKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 539 PEQITINIGKDAPVPPPP-EGHRWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 596

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           G SD +K+EKAR LK +I  IR  Y K    + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 597 GLSDYKKFEKARELKKHIDRIRKDYQKALKHELMVERQKATAVYLIDQFALRAGNEKGED 656

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 657 EAETVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKKEG 716

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   MPGLTAKVFRT+NAS T+  +L      G V EK+  Y  A
Sbjct: 717 DEIFDRLTTSALNKHLSNYMPGLTAKVFRTYNASYTMATLLKDMKATGSVAEKVKAYNDA 776

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V+ SH  QM +++E++  L+     LK+   DLD
Sbjct: 777 NRRVAILCNHKRTVTASHANQMEKMSERIKGLRYQRWRLKQQMLDLD 823



 Score = 85.1 bits (209), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 44/83 (53%), Positives = 57/83 (68%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E LE  I++   +IE M+   + KED K VALGTSKINY+DPR+TV + K+  VPIEK
Sbjct: 916 SVEKLEAAITKLEQRIETMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFNVPIEK 975

Query: 877 IFNKSLLAKFTWAM-DVDPDFRF 898
            F+KSL  KF WA+  VD ++ F
Sbjct: 976 FFSKSLREKFEWAIKSVDENWEF 998


>B0XN02_ASPFC (tr|B0XN02) Topoisomerase I OS=Aspergillus fumigatus (strain CEA10
           / CBS 144.89 / FGSC A1163) GN=AFUB_003910 PE=3 SV=1
          Length = 998

 Score =  427 bits (1097), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 222/467 (47%), Positives = 294/467 (62%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PV L  + EEVA  +  M + T
Sbjct: 359 PTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHPEAEEVAGFFGSMLNAT 418

Query: 404 DYMLKDKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
            ++    F++NF+ D++++L          G    I+    CDF PI+D+          
Sbjct: 419 QHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYDAKRIEKKN 478

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 479 LPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQ 538

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDAP+P  P  G RWKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 539 PEQITINIGKDAPVPPPP-EGHRWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 596

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           G SD +K+EKAR LK +I  IR  Y K    + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 597 GLSDYKKFEKARELKKHIDRIRKDYQKALKHELMVERQKATAVYLIDQFALRAGNEKGED 656

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 657 EAETVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKKEG 716

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   MPGLTAKVFRT+NAS T+  +L      G V EK+  Y  A
Sbjct: 717 DEIFDRLTTSALNKHLSNYMPGLTAKVFRTYNASYTMATLLKDMKATGSVAEKVKAYNDA 776

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V+ SH  QM +++E++  L+     LK+   DLD
Sbjct: 777 NRRVAILCNHKRTVTASHANQMEKMSERIKGLRYQRWRLKQQMLDLD 823



 Score = 85.1 bits (209), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 44/83 (53%), Positives = 57/83 (68%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E LE  I++   +IE M+   + KED K VALGTSKINY+DPR+TV + K+  VPIEK
Sbjct: 916 SVEKLEAAITKLEQRIETMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFNVPIEK 975

Query: 877 IFNKSLLAKFTWAM-DVDPDFRF 898
            F+KSL  KF WA+  VD ++ F
Sbjct: 976 FFSKSLREKFEWAIKSVDENWEF 998


>B5VRP8_YEAST (tr|B5VRP8) YOL006Cp-like protein OS=Saccharomyces cerevisiae
           AWRI1631 GN=AWRI1631_151560 PE=4 SV=1
          Length = 769

 Score =  426 bits (1096), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 217/440 (49%), Positives = 285/440 (64%), Gaps = 11/440 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL HNGVIFPPPYQP    +K+ Y GKPVDL    EEVA  +A + ++D+     F+
Sbjct: 144 KWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAKNPVFQ 203

Query: 413 ENFWNDWRKLLGKNH------VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
           +NF+ND+ ++L ++        I+    CDFT ++D+                       
Sbjct: 204 KNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKKQLTSQEKKQIRLER 263

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   +  +DG +E+VGNF+VEPP LFRGRG HPK GKLKRR+ P DIV+N+ KDAP
Sbjct: 264 EKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKDAP 323

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           +P  P  G +W EIRHDNTV WLA W + I    FKYV LAA+SSLKGQSD +K+EKAR 
Sbjct: 324 VPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNS-FKYVRLAANSSLKGQSDYKKFEKARQ 381

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LK YI  IR  YT++  SK + ++Q AVA YLID  ALRAG EK +DEADTVGCC+L+ E
Sbjct: 382 LKSYIDAIRRDYTRNLKSKVMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLRYE 441

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSKLN 705
           +VT + PN + F+FLGKDSI++   VEV+  V+  +  F++  K+ G  LFD LD S LN
Sbjct: 442 HVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQLFDRLDPSILN 501

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
            +L+  MPGLTAKVFRT+NAS T+ D L+     G V EKI+ Y  AN+ VAI+CNHQR+
Sbjct: 502 KYLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNKGSVAEKILKYNAANRTVAILCNHQRT 561

Query: 766 VSKSHDTQMTRLNEKLDELQ 785
           V+K H   + + N ++ EL+
Sbjct: 562 VTKGHAQTVEKANNRIQELE 581



 Score = 81.6 bits (200), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 38/83 (45%), Positives = 60/83 (72%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E ++ ++ +   +I+     +K KE+   V+LGTSKINY+DPR++V +CK+++VPIEK
Sbjct: 687 SVEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLGTSKINYIDPRLSVVFCKKYDVPIEK 746

Query: 877 IFNKSLLAKFTWAMD-VDPDFRF 898
           IF K+L  KF WA++ VD ++RF
Sbjct: 747 IFTKTLREKFKWAIESVDENWRF 769


>A6ZNK0_YEAS7 (tr|A6ZNK0) Topoisomerase I OS=Saccharomyces cerevisiae (strain
           YJM789) GN=TOP1 PE=3 SV=1
          Length = 769

 Score =  426 bits (1096), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 217/440 (49%), Positives = 285/440 (64%), Gaps = 11/440 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL HNGVIFPPPYQP    +K+ Y GKPVDL    EEVA  +A + ++D+     F+
Sbjct: 144 KWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAKNPVFQ 203

Query: 413 ENFWNDWRKLLGKNH------VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
           +NF+ND+ ++L ++        I+    CDFT ++D+                       
Sbjct: 204 KNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKKQLTSQEKKQIRLER 263

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   +  +DG +E+VGNF+VEPP LFRGRG HPK GKLKRR+ P DIV+N+ KDAP
Sbjct: 264 EKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKDAP 323

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           +P  P  G +W EIRHDNTV WLA W + I    FKYV LAA+SSLKGQSD +K+EKAR 
Sbjct: 324 VPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNS-FKYVRLAANSSLKGQSDYKKFEKARQ 381

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LK YI  IR  YT++  SK + ++Q AVA YLID  ALRAG EK +DEADTVGCC+L+ E
Sbjct: 382 LKSYIDAIRRDYTRNLKSKVMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLRYE 441

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSKLN 705
           +VT + PN + F+FLGKDSI++   VEV+  V+  +  F++  K+ G  LFD LD S LN
Sbjct: 442 HVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQLFDRLDPSILN 501

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
            +L+  MPGLTAKVFRT+NAS T+ D L+     G V EKI+ Y  AN+ VAI+CNHQR+
Sbjct: 502 KYLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNKGSVAEKILKYNAANRTVAILCNHQRT 561

Query: 766 VSKSHDTQMTRLNEKLDELQ 785
           V+K H   + + N ++ EL+
Sbjct: 562 VTKGHAQTVEKANNRIQELE 581



 Score = 81.6 bits (200), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 38/83 (45%), Positives = 60/83 (72%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E ++ ++ +   +I+     +K KE+   V+LGTSKINY+DPR++V +CK+++VPIEK
Sbjct: 687 SVEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLGTSKINYIDPRLSVVFCKKYDVPIEK 746

Query: 877 IFNKSLLAKFTWAMD-VDPDFRF 898
           IF K+L  KF WA++ VD ++RF
Sbjct: 747 IFTKTLREKFKWAIESVDENWRF 769


>B2WCA4_PYRTR (tr|B2WCA4) DNA topoisomerase 1 OS=Pyrenophora tritici-repentis
           (strain Pt-1C-BFP) GN=PTRG_07613 PE=4 SV=1
          Length = 905

 Score =  426 bits (1096), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 214/453 (47%), Positives = 289/453 (63%), Gaps = 16/453 (3%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTD 404
           P   DG KKW TL H GV+FPP Y+P    VK++Y G PV L  D EEVAT Y  M ++ 
Sbjct: 266 PGKNDGTKKWDTLEHAGVVFPPEYEPLPKHVKLVYDGVPVTLHKDAEEVATFYGSMLNST 325

Query: 405 YMLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
           + +++  F +NF+ D+  +L          G    I+  + CDF PI++W          
Sbjct: 326 HNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKPIFEWFDAERAKKKA 385

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPPGLFRGRGEHPK G++K+R+ 
Sbjct: 386 LSAAEKKALKAEKEAAEADYMYCLWDGRKQKVGNFRVEPPGLFRGRGEHPKTGRVKKRVM 445

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIG++A +PE P  G RWKEI+HD+  TWLA W + IN   +KYV LAA+S +K
Sbjct: 446 PEQITINIGENAKVPEPPA-GHRWKEIKHDHEGTWLAMWQENING-AYKYVMLAANSDIK 503

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y KD  SK +  +Q A A YLID+ ALRAGNEK +D
Sbjct: 504 GQSDFKKFEKARELKKHIDRIRKDYRKDLNSKMMADRQRATAIYLIDQFALRAGNEKGED 563

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EADTVGCC+LK +++T   P  + F+FLGKDSI++ + V+V+  V+  +  F+K+ K  G
Sbjct: 564 EADTVGCCSLKFQHITLRPPETVIFDFLGKDSIRFYDEVKVDPQVFKNLKLFKKEPKTTG 623

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           DD+FD L TS LN HL   MPGLTAKVFRT+NAS T+  +L +    G V EK+  Y  A
Sbjct: 624 DDIFDRLTTSALNKHLTSYMPGLTAKVFRTYNASYTMARLLKEMKATGTVQEKVKAYNDA 683

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           N++VAI+CNH+R+V+ SH T + ++NE+++ L+
Sbjct: 684 NREVAILCNHKRTVAASHATSIEKMNERINGLR 716



 Score = 79.7 bits (195), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 41/81 (50%), Positives = 55/81 (67%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  + +   +IE M+  M+ KE  K VALGTSKINY+DPR+TV + K+  VPIEK F
Sbjct: 825 EKLEANVEKIVQRIENMKIQMEDKEGNKEVALGTSKINYIDPRLTVVFSKKFGVPIEKFF 884

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +K+L  KF WA+  VD ++ F
Sbjct: 885 SKTLREKFDWAIKSVDENWEF 905


>B3LJ50_YEAS1 (tr|B3LJ50) DNA topoisomerase I OS=Saccharomyces cerevisiae (strain
           RM11-1a) GN=SCRG_01397 PE=4 SV=1
          Length = 769

 Score =  426 bits (1095), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 217/440 (49%), Positives = 285/440 (64%), Gaps = 11/440 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL HNGVIFPPPYQP    +K+ Y GKPVDL    EEVA  +A + ++D+     F+
Sbjct: 144 KWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAKNPVFQ 203

Query: 413 ENFWNDWRKLLGKNH------VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
           +NF+ND+ ++L ++        I+    CDFT ++D+                       
Sbjct: 204 KNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKKQLTSQEKKQIRLER 263

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   +  +DG +E+VGNF+VEPP LFRGRG HPK GKLKRR+ P DIV+N+ KDAP
Sbjct: 264 EKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKDAP 323

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           +P  P  G +W EIRHDNTV WLA W + I    FKYV LAA+SSLKGQSD +K+EKAR 
Sbjct: 324 VPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNS-FKYVRLAANSSLKGQSDYKKFEKARQ 381

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LK YI  IR  YT++  SK + ++Q AVA YLID  ALRAG EK +DEADTVGCC+L+ E
Sbjct: 382 LKSYIDAIRRDYTRNLKSKLMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLRYE 441

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSKLN 705
           +VT + PN + F+FLGKDSI++   VEV+  V+  +  F++  K+ G  LFD LD S LN
Sbjct: 442 HVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQLFDRLDPSILN 501

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
            +L+  MPGLTAKVFRT+NAS T+ D L+     G V EKI+ Y  AN+ VAI+CNHQR+
Sbjct: 502 KYLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNKGSVAEKILKYNAANRTVAILCNHQRT 561

Query: 766 VSKSHDTQMTRLNEKLDELQ 785
           V+K H   + + N ++ EL+
Sbjct: 562 VTKGHAQTVEKANNRIQELE 581



 Score = 81.6 bits (200), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 38/83 (45%), Positives = 60/83 (72%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E ++ ++ +   +I+     +K KE+   V+LGTSKINY+DPR++V +CK+++VPIEK
Sbjct: 687 SVEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLGTSKINYIDPRLSVVFCKKYDVPIEK 746

Query: 877 IFNKSLLAKFTWAMD-VDPDFRF 898
           IF K+L  KF WA++ VD ++RF
Sbjct: 747 IFTKTLREKFKWAIESVDENWRF 769


>Q75CB7_ASHGO (tr|Q75CB7) ACL008Cp OS=Ashbya gossypii GN=ACL008C PE=3 SV=1
          Length = 732

 Score =  424 bits (1091), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 251/632 (39%), Positives = 350/632 (55%), Gaps = 86/632 (13%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           D   KW TL HNGV+FPP Y P    V++ Y GK V+L A+ EEVA  +A +  +D+   
Sbjct: 103 DDSVKWVTLRHNGVMFPPEYTPLPSHVRLYYGGKAVELPAEAEEVAGFFAALLQSDHAQN 162

Query: 409 DKFKENFWNDWRKLLGKNHV------IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXX 462
             F++NF+ D+  +L K+        IQ    CDF+ ++ +                   
Sbjct: 163 PVFQKNFFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQQRVQMKQLSSHERKLL 222

Query: 463 XXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIG 522
                         ++ G KE+V  F+++PP LFRGRG HPK GKLKRR++P D+V+N+ 
Sbjct: 223 KQEKGQTEGPVQVLLLTGRKEQVDTFKIDPPDLFRGRGAHPKTGKLKRRVQPEDVVLNLD 282

Query: 523 KDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYE 582
           KDAPIPE P  G +W EIRHDNTV WL  W + I+   FKYV LAA+SSLKG SD +K+E
Sbjct: 283 KDAPIPEPP-AGHKWGEIRHDNTVQWLCMWRENISNS-FKYVRLAANSSLKGMSDFKKFE 340

Query: 583 KARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 642
           K+R LK+YI  IRA Y K+  SK +  +QIAVATYLID  ALRAG EK +DEADTVGCC+
Sbjct: 341 KSRELKNYIDIIRADYRKNLKSKVMLDRQIAVATYLIDVFALRAGGEKSEDEADTVGCCS 400

Query: 643 LKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDT 701
           L+ E+++ + PN + F+FLGKDSI+Y   VEV+  V+  +  F++  K+ G  LFD LD 
Sbjct: 401 LRYEHISLKPPNTVVFDFLGKDSIRYYQEVEVDKQVFKNLSIFKRPPKEPGHQLFDRLDP 460

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICN 761
           S LN HL+  MPGLTAKVFRT+NAS T+ D L+    +G V EK+V Y  AN+ VAI+CN
Sbjct: 461 SILNKHLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNEGSVTEKMVRYNAANRAVAILCN 520

Query: 762 HQRSVSKSHDTQMTRLNEKLDELQ--------AVLK----ELRTD--------------- 794
           HQR+V +SH   M +  EK++E Q        A+L+    EL+ +               
Sbjct: 521 HQRTVGRSHAQSMQKATEKIEEYQWQKIRYKKAILQLDESELKANPKFFKEINDLTKEEQ 580

Query: 795 -------LDRARXXXXXXXXXXXXXXXNLSSEAL-EKKISQTNAKIEKMQRD-------- 838
                  L+R R                   E L E ++    A +E+M ++        
Sbjct: 581 MSIHKRVLEREREKYQKKFARENEKRKFEGEELLPESQLESWLADVEEMGKEYVEELETG 640

Query: 839 -MKTKEDLKTVALGTSKINYLDPRI--------------TVA----------------WC 867
            +  K  L++V    ++I+ L+ RI              TVA                +C
Sbjct: 641 LVTVKPTLQSVEKLKAQIDKLEQRIRTTSIQMKDKEDNSTVALSTSKISYIDPRLSVAFC 700

Query: 868 KRHEVPIEKIFNKSLLAKFTWAMD-VDPDFRF 898
           K+++VP+EK+F K+L  KF WA++  D ++RF
Sbjct: 701 KKYDVPLEKVFTKTLREKFKWAIESADENWRF 732


>Q5BGS7_EMENI (tr|Q5BGS7) Putative uncharacterized protein OS=Emericella nidulans
           GN=AN0253.2 PE=3 SV=1
          Length = 871

 Score =  424 bits (1089), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 219/467 (46%), Positives = 297/467 (63%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PVDL  + EEVA  +  M + T
Sbjct: 232 PTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFGSMLNST 291

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
            +     F++NF+ D++++L K         N V I+    CDF PI+ +          
Sbjct: 292 QHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQRQEKKA 351

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 352 LPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQ 411

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK+A +P  P  G +WKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 412 PEQITINIGKEARVPPPP-EGHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 469

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K+   + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 470 GQSDYKKFEKARELKKHIARIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGED 529

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 530 EAETVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKKEG 589

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL + MPGLTAKVFRT+NAS T+ ++L      G+  EK+  Y  A
Sbjct: 590 DEIFDRLTTSALNKHLSQYMPGLTAKVFRTYNASHTMSELLKSMHATGNNAEKVKAYNDA 649

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V  +H  QM +++E++   +     LK++  DLD
Sbjct: 650 NRKVAILCNHKRTVGAAHAHQMEKMSERIKGQRYQKWRLKQMMLDLD 696



 Score = 85.1 bits (209), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 43/81 (53%), Positives = 57/81 (70%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  I++   +IE M+   + KED K VALGTSKINY+DPR+TV + K+ +VPIEK F
Sbjct: 791 EKLEASITKLQQRIENMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFKVPIEKFF 850

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +KSL  KF WA+  VD ++ F
Sbjct: 851 SKSLREKFEWAIKSVDENWEF 871


>Q875K2_EMENI (tr|Q875K2) Topoisomerase I OS=Emericella nidulans PE=3 SV=1
          Length = 871

 Score =  423 bits (1087), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 219/467 (46%), Positives = 297/467 (63%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PVDL  + EEVA  +  M + T
Sbjct: 232 PTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFGSMLNST 291

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
            +     F++NF+ D++++L K         N V I+    CDF PI+ +          
Sbjct: 292 QHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQRQEKKA 351

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 352 LPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPPLFRGRGEHPKTGRVKARVQ 411

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK+A +P  P  G +WKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 412 PEQITINIGKEARVPPPP-EGHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 469

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K+   + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 470 GQSDYKKFEKARELKKHIARIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGED 529

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 530 EAETVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKKEG 589

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL + MPGLTAKVFRT+NAS T+ ++L      G+  EK+  Y  A
Sbjct: 590 DEIFDRLTTSALNKHLSQYMPGLTAKVFRTYNASHTMSELLKSMHATGNNAEKVKAYNDA 649

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V  +H  QM +++E++   +     LK++  DLD
Sbjct: 650 NRKVAILCNHKRTVGAAHAHQMEKMSERIKGQRYQKWRLKQMMLDLD 696



 Score = 85.1 bits (209), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 43/81 (53%), Positives = 57/81 (70%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  I++   +IE M+   + KED K VALGTSKINY+DPR+TV + K+ +VPIEK F
Sbjct: 791 EKLEASITKLQQRIENMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFKVPIEKFF 850

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +KSL  KF WA+  VD ++ F
Sbjct: 851 SKSLREKFEWAIKSVDENWEF 871


>Q1DXZ1_COCIM (tr|Q1DXZ1) Putative uncharacterized protein OS=Coccidioides
           immitis GN=CIMG_04822 PE=3 SV=1
          Length = 905

 Score =  421 bits (1081), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 215/467 (46%), Positives = 294/467 (62%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTD 404
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G P+ L  D EEVA  +  M ++ 
Sbjct: 266 PTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFGSMLNST 325

Query: 405 YMLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
           + +++  F++NF+ D+  ++          G   +I++ K CDF PI+++          
Sbjct: 326 HNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYEMKREEKKA 385

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 386 LPAAERKRLKAEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKIRVQ 445

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK A +P  P  G +WKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 446 PEQITINIGKGAAVPPPPA-GHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDIK 503

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K    + +  +Q A A YLID+ ALRAGNEK +D
Sbjct: 504 GQSDFKKFEKARELKKHIDRIRKDYRKGLKDELMANRQRATAVYLIDQFALRAGNEKGED 563

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EADTVGCC+LK E+VT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 564 EADTVGCCSLKYEHVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKAPKKDG 623

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   M GLTAKVFRT+NAS T+  +L +    G + EK+  Y  A
Sbjct: 624 DEIFDRLTTSALNKHLSGYMAGLTAKVFRTYNASYTMATLLRQMNATGTIHEKVKQYNDA 683

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V+  H  QM +L E++  L+     +K++  DLD
Sbjct: 684 NRKVAILCNHKRTVAAGHANQMEKLGERIKGLRYQKWRIKQMMLDLD 730



 Score = 78.2 bits (191), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 39/81 (48%), Positives = 55/81 (67%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E  E  +++ + +I+ M    + KED K VALGTSKINY+DPR+TV + K+  VPIEK F
Sbjct: 825 EKYENNLAKLDQRIDTMSLQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFSVPIEKFF 884

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +K+L  KF WA+  VD ++ F
Sbjct: 885 SKTLREKFDWAIKSVDENWEF 905


>Q7Z012_9TRYP (tr|Q7Z012) Type IB DNA topoisomerase large subunit OS=Trypanosoma
           brucei PE=3 SV=1
          Length = 696

 Score =  421 bits (1081), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 208/450 (46%), Positives = 291/450 (64%), Gaps = 7/450 (1%)

Query: 346 LPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDY 405
           L ++  G+K+W TL+HNGV+FPP Y PH + +LY  +  ++T ++EEVATM+AV+R+ DY
Sbjct: 99  LTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFEMTPEEEEVATMFAVLREHDY 158

Query: 406 MLKDKFKENFWNDWRKLLGKN-HVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
              + F+ NF+  WR++L K  H I+ L+ CDF+ IY+W                     
Sbjct: 159 YRNEVFRRNFFQSWREILDKRKHPIRCLELCDFSAIYEWHQREVEKRKSRTREEKKELKR 218

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                     W I +G KE+V NFRVEPPGLFRGRGEHP  GKLK+RI P D+V+NIGK+
Sbjct: 219 IADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMRGKLKKRILPEDVVLNIGKE 278

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
           APIP+ P  G +WK + HD  VTWLA W +P   +  KYV LA SS+LKGQSD  K+E A
Sbjct: 279 APIPQAP-AGHKWKGVVHDQNVTWLAMWYEPTIGQC-KYVMLAPSSTLKGQSDYAKFETA 336

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 644
           R LK++I +IR +YTKDF+S D  ++Q AVATY IDKLALR G+EK ++EADTVGCC+L+
Sbjct: 337 RELKNHIDDIRESYTKDFSSTDEMERQRAVATYFIDKLALRVGHEKGEEEADTVGCCSLR 396

Query: 645 VENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
            E++     N ++F+FLGKDSI+Y N V V   VY  +  F   K+   ++F  +  + L
Sbjct: 397 KEHIELRPDNVVRFDFLGKDSIRYVNEVTVLPEVYKLLGSFI--KRTDSEIFRKVTPTTL 454

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKD--GDVGEKIVVYQHANKQVAIICNH 762
           N +LK  +  L+AKVFRT+NASITLD+   +   D    + +K+V +  AN +VA +CNH
Sbjct: 455 NNYLKSFLKDLSAKVFRTYNASITLDEWFREKPVDPKASLSDKLVYFNKANTEVAKLCNH 514

Query: 763 QRSVSKSHDTQMTRLNEKLDELQAVLKELR 792
           QRS+ K+    +  +  KL++++  +  LR
Sbjct: 515 QRSIPKTFHVSVQSIKYKLEDIKRTIDTLR 544


>Q581U8_9TRYP (tr|Q581U8) DNA topoisomerase IB, large subunit OS=Trypanosoma
           brucei GN=Tb927.4.1330 PE=3 SV=1
          Length = 661

 Score =  420 bits (1079), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 208/450 (46%), Positives = 291/450 (64%), Gaps = 7/450 (1%)

Query: 346 LPSSGDGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDY 405
           L ++  G+K+W TL+HNGV+FPP Y PH + +LY  +  ++T ++EEVATM+AV+R+ DY
Sbjct: 64  LTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFEMTPEEEEVATMFAVLREHDY 123

Query: 406 MLKDKFKENFWNDWRKLLGKN-HVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
              + F+ NF+  WR++L K  H I+ L+ CDF+ IY+W                     
Sbjct: 124 YRNEVFRRNFFQSWREILDKRKHPIRCLELCDFSAIYEWHQREVEKRKSRTREEKKELKR 183

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                     W I +G KE+V NFRVEPPGLFRGRGEHP  GKLK+RI P D+V+NIGK+
Sbjct: 184 IADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMRGKLKKRILPEDVVLNIGKE 243

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
           APIP+ P  G +WK + HD  VTWLA W +P   +  KYV LA SS+LKGQSD  K+E A
Sbjct: 244 APIPQAP-AGHKWKGVVHDQNVTWLAMWYEPTIGQC-KYVMLAPSSTLKGQSDYAKFETA 301

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 644
           R LK++I +IR +YTKDF+S D  ++Q AVATY IDKLALR G+EK ++EADTVGCC+L+
Sbjct: 302 RELKNHIDDIRESYTKDFSSTDEMERQRAVATYFIDKLALRVGHEKGEEEADTVGCCSLR 361

Query: 645 VENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKL 704
            E++     N ++F+FLGKDSI+Y N V V   VY  +  F   K+   ++F  +  + L
Sbjct: 362 KEHIELRPDNVVRFDFLGKDSIRYVNEVTVLPEVYKLLGSFI--KRTDSEIFRKVTPTTL 419

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKD--GDVGEKIVVYQHANKQVAIICNH 762
           N +LK  +  L+AKVFRT+NASITLD+   +   D    + +K+V +  AN +VA +CNH
Sbjct: 420 NNYLKSFLKDLSAKVFRTYNASITLDEWFREKPVDPKASLSDKLVYFNKANTEVAKLCNH 479

Query: 763 QRSVSKSHDTQMTRLNEKLDELQAVLKELR 792
           QRS+ K+    +  +  KL++++  +  LR
Sbjct: 480 QRSIPKTFHVSVQSIKYKLEDIKRTIDTLR 509


>B4DYD2_HUMAN (tr|B4DYD2) cDNA FLJ50294, highly similar to DNA topoisomerase I,
           mitochondrial (EC 5.99.1.2) OS=Homo sapiens PE=2 SV=1
          Length = 503

 Score =  420 bits (1079), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 226/512 (44%), Positives = 310/512 (60%), Gaps = 22/512 (4%)

Query: 400 MRDTDYMLKDKFKENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXX 457
           M D +Y  K+ F++NF+NDWRK +   +  VI++L  CDFT I+ +              
Sbjct: 1   MLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSRE 60

Query: 458 XXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDI 517
                            + I+DG +EK+GNF++EPPGLFRGRG+HPKMG LKRRI P D+
Sbjct: 61  EKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDV 120

Query: 518 VINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSD 577
           VIN  +D+ IPE P  G +WKE+R DNTVTWLA W + I   + KY+ L   S LKG++ 
Sbjct: 121 VINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESIQNSI-KYIMLNPCSKLKGETA 178

Query: 578 KEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEA-D 636
            +K+E AR L+ ++  IR+ Y  D+ S+++  +Q AVA Y IDKLALRAGNEK+D EA D
Sbjct: 179 WQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAAD 238

Query: 637 TVGCCTLKVENVTRE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKG 691
           TVGCC+L+VE+V          + ++F+FLGKD I+Y N V VE PVY  +  F ++K  
Sbjct: 239 TVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDP 298

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQ 750
            DDLFD L T+ LN HL+ELM GLTAKVFRT+NASITL + L   T+  D +  KI+ Y 
Sbjct: 299 RDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYN 358

Query: 751 HANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXX 810
            AN+ VAI+CNHQR+   + +  M         LQ  ++  +  +  AR           
Sbjct: 359 RANRVVAILCNHQRATPSTFEKSM-------QNLQTKIQAKKEQVAEARAELRRARAEHK 411

Query: 811 XXXXNLSSEALEKK---ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWC 867
                 S   LEKK   + +   ++ ++      KE+ K VALGTSK+NYLDPRI++AWC
Sbjct: 412 AQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWC 471

Query: 868 KRHEVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
           KR  VP+EKI++K+   +F WA+ +   DF F
Sbjct: 472 KRFRVPVEKIYSKTQRERFAWALAMAGEDFEF 503


>A7TJW1_VANPO (tr|A7TJW1) Putative uncharacterized protein OS=Vanderwaltozyma
           polyspora (strain ATCC 22028 / DSM 70294)
           GN=Kpol_1037p19 PE=3 SV=1
          Length = 799

 Score =  419 bits (1078), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 215/444 (48%), Positives = 289/444 (65%), Gaps = 11/444 (2%)

Query: 351 DGQKKWTTLVHNGVIFPPPY--QPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           +G+ +WTTL HNGV+FPPPY   P  +K+ Y G+ VDL    EEVA  +A +  TD+   
Sbjct: 170 NGEIQWTTLRHNGVMFPPPYVSLPSHIKLYYNGQAVDLPPTAEEVAGFFAALLHTDHAKN 229

Query: 409 DKFKENFWNDWRKLLGK-----NHV-IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXX 462
             F++NF+ D++++L +     N + ++  + CDF+ ++++                   
Sbjct: 230 TVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEIQREQRKKLSPQEKKQL 289

Query: 463 XXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIG 522
                       +  +DG +E+VGNFRVEPP LFRGRG HPK GKLKRR+ P DIV+N+ 
Sbjct: 290 RLEKEEQEEPFKFCELDGRREQVGNFRVEPPDLFRGRGAHPKTGKLKRRVYPEDIVLNLD 349

Query: 523 KDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYE 582
           ++APIP  P  G +W EI+HDNTV WLA W + I+   FKYV LAA+SSLKGQSD +K+E
Sbjct: 350 RNAPIPAVP-EGHKWGEIKHDNTVQWLAMWRENISNS-FKYVRLAANSSLKGQSDFKKFE 407

Query: 583 KARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 642
           KAR LK YI +IR  Y  +  SK + ++Q AVA YLID  ALRAG EK DDEADTVGCC+
Sbjct: 408 KARELKKYIDSIRKDYRTNLKSKLMLERQKAVAIYLIDVFALRAGGEKSDDEADTVGCCS 467

Query: 643 LKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDT 701
           L+ E+VT + PN + F+FLGKDSI++   VEV+  V+  +  F++  KK GD LFD LD 
Sbjct: 468 LRYEHVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLAIFKRAPKKPGDQLFDRLDP 527

Query: 702 SKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICN 761
             LN HL+  MPGLTAKVFRT+NAS T+ D L+     G V EK++ Y  AN+ VAI+CN
Sbjct: 528 PILNKHLQNYMPGLTAKVFRTYNASKTMQDQLDLIVNKGSVAEKMLRYNAANRTVAILCN 587

Query: 762 HQRSVSKSHDTQMTRLNEKLDELQ 785
           HQRSV K H   + + NEK++EL+
Sbjct: 588 HQRSVGKGHAEAVRKANEKIEELE 611



 Score = 85.1 bits (209), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 41/81 (50%), Positives = 58/81 (71%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LEK I +   +I+     +K KE+   V+LGTSKINY+DPR++V +CK+ ++PIEKIF
Sbjct: 719 EKLEKNIEKLEQRIQTSSIQLKDKEENSQVSLGTSKINYIDPRLSVVFCKKFDIPIEKIF 778

Query: 879 NKSLLAKFTWAMD-VDPDFRF 898
            KSL  KF WA++ VD ++RF
Sbjct: 779 TKSLREKFRWAIESVDENWRF 799


>B6QNQ2_PENMA (tr|B6QNQ2) Topoisomerase I OS=Penicillium marneffei ATCC 18224
           GN=PMAA_053460 PE=4 SV=1
          Length = 860

 Score =  417 bits (1072), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 214/453 (47%), Positives = 283/453 (62%), Gaps = 16/453 (3%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTD 404
           P+ GDG  KW TL HNGV+FPP Y+P    VKM Y G PV L  + EEVA  +  M ++ 
Sbjct: 221 PTKGDGTIKWNTLEHNGVVFPPEYEPLPKNVKMKYDGVPVVLHPEAEEVAGFFGAMLNST 280

Query: 405 YMLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
           + +++  F++NF+ D++ +L          G+   I+  K CDF PI+++          
Sbjct: 281 HNVENPTFQKNFFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIFEYYEGKRLEKKN 340

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + I DG K+KVGNFRVEPP LFRGRGEHPK GK+K R+ 
Sbjct: 341 LSAAEKKALKAERDEAEAPYMYCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKTRVM 400

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDA +P  P  G +WKE+RHD   TWLA W + +N   +KYV LAA+S +K
Sbjct: 401 PEQITINIGKDAKVPPPP-EGHKWKEVRHDQEGTWLAMWQENVNGN-YKYVMLAANSDIK 458

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K   S  +  +Q A A YLIDK ALRAGNEK +D
Sbjct: 459 GQSDYKKFEKARELKKHIDKIREDYRKGLKSDLMADRQRATAVYLIDKFALRAGNEKGED 518

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EADTVGCC+LK EN++   PN + F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 519 EADTVGCCSLKYENISLRPPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKAPKKEG 578

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   MPGLTAKVFRT+NAS T   +L     +G V EK+  Y  A
Sbjct: 579 DEIFDRLTTSALNKHLSNYMPGLTAKVFRTYNASYTFATLLKDMKAEGTVAEKVKQYNDA 638

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           N++VAI+CNH+R+V+  H  QM +L +++  L+
Sbjct: 639 NRRVAILCNHKRTVTAGHANQMEKLGDRIKGLR 671



 Score = 80.1 bits (196), Expect = 8e-13,   Method: Compositional matrix adjust.
 Identities = 40/81 (49%), Positives = 55/81 (67%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  +++   +IE M    + KE+ K VALGTSKINY+DPR+TV + K+  VPIEK F
Sbjct: 780 EKLENNVTKLEQRIENMSLQAEDKENNKEVALGTSKINYIDPRLTVVFTKKFNVPIEKFF 839

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +K+L  KF WA+  V+ D+ F
Sbjct: 840 SKTLREKFDWAIKSVEEDWEF 860


>A5DLX4_PICGU (tr|A5DLX4) Putative uncharacterized protein OS=Pichia
           guilliermondii GN=PGUG_04275 PE=3 SV=2
          Length = 754

 Score =  416 bits (1070), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 245/629 (38%), Positives = 348/629 (55%), Gaps = 83/629 (13%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           DG++KW +L HNGV+FPP Y+P    VKM Y GKPVDL    EEVA  +A M +TD+   
Sbjct: 128 DGEQKWESLHHNGVMFPPEYEPLPSHVKMYYDGKPVDLAPAAEEVAGFFAAMLETDHAQN 187

Query: 409 DKFKENFWNDWRKLL----GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
             F++NFWND+ +++    G N  +++    DFT ++                       
Sbjct: 188 PVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFEMLKEQKKNMSRDEKKALKE 247

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                       +++G KE+VGNFRVEPPGLFRGRG HPK GKLK+R+ P DI +N+ K+
Sbjct: 248 AKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPKTGKLKKRVYPEDITLNLSKE 307

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
             +PE P  G +W E+RHDNTV WLA W + I+  L KYV  AA+SS+KGQSD +K+E A
Sbjct: 308 CKVPEPPA-GHKWGEVRHDNTVAWLAMWKENISDSL-KYVRFAANSSVKGQSDFKKFETA 365

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 644
           R LK +I  IR  YTK      +  +Q+A ATYLID  ALRAG EK DDEADTVGCC+L+
Sbjct: 366 RNLKFHIDAIRTDYTKLLKDPLMQNRQMATATYLIDVFALRAGGEKGDDEADTVGCCSLR 425

Query: 645 VENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSK 703
            E++T + PN++ F+FLGKDSI++   VEV+  V+  +  F+K  K+ GDDLFD +    
Sbjct: 426 YEHITLKPPNQVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKPPKQPGDDLFDRISPPM 485

Query: 704 LNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQ 763
           LN   +  M GLTAKVFRT+NAS T+ D ++    +G V EK+V +  AN+ VAI+CNHQ
Sbjct: 486 LNKQFQGYMKGLTAKVFRTYNASKTMQDQIDLIPNEGTVAEKVVRFNAANRTVAILCNHQ 545

Query: 764 RSVSKSHDTQMTRLNEKLDEL-------QAVLKEL-----RTD----------------- 794
           R+VSK+H   + R+++++ E+       + ++ EL     R D                 
Sbjct: 546 RTVSKTHGHSVQRIHDRIKEMMWQKIRTKKMILELEPGLRRKDPKYFEELEDLSKEDEQH 605

Query: 795 -----LDRARXXXXXXXXXXXXXXXN-----LSSEALEKKISQTNAKIEKMQRDMKTKED 844
                L+RAR                     LSS  L++K+ +   + + +  ++KT + 
Sbjct: 606 VHHLLLERAREQAQRKFERENQKLKAEGKELLSSSVLDEKMEKIKEQEKDLAEELKTGKP 665

Query: 845 L----KTVALGTSKINYLDPRI------------------------------TVAWCKRH 870
           +     TV    +++  LD RI                              TV + K+ 
Sbjct: 666 VMKSTTTVEKLKAQVEKLDGRIVNTTFQLQDKEDNSEVSLGTSKLNYIDPRLTVMFSKKF 725

Query: 871 EVPIEKIFNKSLLAKFTWAMD-VDPDFRF 898
           +VPIEK+F K+L  KF WA++  D ++RF
Sbjct: 726 DVPIEKLFTKTLRDKFKWAIESADENWRF 754


>Q6CUB9_KLULA (tr|Q6CUB9) KLLA0C06116p OS=Kluyveromyces lactis GN=KLLA0C06116g
           PE=3 SV=1
          Length = 785

 Score =  416 bits (1070), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 214/440 (48%), Positives = 282/440 (64%), Gaps = 11/440 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KWTTL HNGVIFP  Y+P    VK+ Y GKPVDL    EEVA  +A + ++D++    F+
Sbjct: 160 KWTTLKHNGVIFPSTYEPLPAHVKLYYNGKPVDLPPQAEEVAGFFAAILESDHVKIPTFQ 219

Query: 413 ENFWNDWRKLLGKNH------VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
           +NF +D+ ++L +N        I+     DFT I+++                       
Sbjct: 220 KNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQVQKEQKKQLSPQEKKQLRLEK 279

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   +  +DG  E+VGNFR+EPPGLFRGRG HPK GKLKRR+ P D+V+N+ K+AP
Sbjct: 280 EELEKPYKFCEIDGRVEQVGNFRIEPPGLFRGRGAHPKNGKLKRRVYPEDVVLNLDKEAP 339

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           IPE P  G +W EIRHDNTV WL+ W + I+   FKYV  AA+S+LKG SD +K+EKARM
Sbjct: 340 IPEPP-KGHKWGEIRHDNTVQWLSMWRENISNS-FKYVRFAANSTLKGMSDFKKFEKARM 397

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LKD+I  +R  Y     S     +Q+AVATYLID  ALRAG EK DDEADTVGCC+L+ E
Sbjct: 398 LKDHIDKVRTDYKSKMKSPKTLDRQMAVATYLIDVFALRAGGEKADDEADTVGCCSLRYE 457

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKG-GDDLFDMLDTSKLN 705
           +VT   PN + F+FLGKDSI+Y   VEV+  V+  +  F++   G G  LFD LD S LN
Sbjct: 458 HVTLRPPNTVVFDFLGKDSIRYYQEVEVDAQVFKNLKIFKRPPSGPGHQLFDRLDPSILN 517

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
            HL+  MPGLTAKVFRT+NAS T+ D L+    +G V EKI+ Y  AN+ VAI+CNHQR+
Sbjct: 518 KHLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNEGTVAEKILRYNAANRTVAILCNHQRT 577

Query: 766 VSKSHDTQMTRLNEKLDELQ 785
           V+K H + + +  E+++EL+
Sbjct: 578 VTKGHASSVQKATERIEELE 597



 Score = 81.6 bits (200), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 37/73 (50%), Positives = 53/73 (72%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E L++ + +   +I      +K KED  TVALGTSKINY+DPR++VA+CK+ +VPIEK+F
Sbjct: 705 EKLKQNVEKLEKRITNCSLQLKDKEDNSTVALGTSKINYIDPRLSVAFCKKFDVPIEKVF 764

Query: 879 NKSLLAKFTWAMD 891
            K+L  KF WA++
Sbjct: 765 TKTLRDKFRWAIE 777


>A1CRV8_ASPCL (tr|A1CRV8) Topoisomerase I OS=Aspergillus clavatus GN=ACLA_031120
           PE=3 SV=1
          Length = 886

 Score =  416 bits (1069), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 214/453 (47%), Positives = 285/453 (62%), Gaps = 16/453 (3%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PV L  + EEVA  +  M + T
Sbjct: 247 PTKGDGTIKWTTLEHNGVVFPPPYEPLPQDVKMKYDGIPVTLHPEAEEVAGFFGSMLNAT 306

Query: 404 DYMLKDKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
            ++    F++NF++D++ +L          G    I+    CDF  I+ +          
Sbjct: 307 QHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQSIFAYYDAKRIEKRN 366

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 367 IPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQ 426

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK AP+P  P  G RWKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 427 PEQITINIGKGAPVPPPP-EGHRWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 484

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K    + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 485 GQSDFKKFEKARELKKHIDRIRKDYQKSLKHELMVERQKATAVYLIDQFALRAGNEKGED 544

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGG 692
           EADTVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 545 EADTVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDAQVFKNLKIFKKAPKKEG 604

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL   M GLTAKVFRT+NAS T+  +L      G+  EK+  Y  A
Sbjct: 605 DEIFDRLTTSALNKHLSTYMQGLTAKVFRTYNASYTMATLLKDMKATGNNAEKVKAYNDA 664

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           N++VAI+CNH+R+V+ SH  QM +++E++  L+
Sbjct: 665 NRRVAILCNHKRTVTASHANQMEKMSERIKGLR 697



 Score = 82.0 bits (201), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 41/79 (51%), Positives = 55/79 (69%), Gaps = 1/79 (1%)

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           +E  I++   +IE M+   + KED K VALGTSKINY+DPR+TV + K+  VPIEK F+K
Sbjct: 808 IEAAITKLEQRIETMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFNVPIEKFFSK 867

Query: 881 SLLAKFTWAM-DVDPDFRF 898
           SL  KF WA+  VD ++ F
Sbjct: 868 SLREKFEWAIKSVDENWEF 886


>B6H1W4_PENCH (tr|B6H1W4) Pc13g03270 protein OS=Penicillium chrysogenum Wisconsin
           54-1255 GN=Pc13g03270 PE=4 SV=1
          Length = 864

 Score =  415 bits (1066), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 217/467 (46%), Positives = 298/467 (63%), Gaps = 20/467 (4%)

Query: 348 SSGDGQKKWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDY 405
           S GDG  KWTTL HNGV+FPP Y+  P  VKM Y G P+ L  + EEVA+ +  M ++ +
Sbjct: 225 SKGDGTIKWTTLEHNGVVFPPEYELLPQNVKMKYDGIPITLAPEAEEVASFFGTMLNSTH 284

Query: 406 MLKDK-FKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXXX 454
            +++  F++NF++D++ ++ K         N V I+    CDF PI+++           
Sbjct: 285 NVENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIFEFYDAQREEKRHL 344

Query: 455 XXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRP 514
                               + I DG K+KVGNFRVEPP LFRGRGEHPK G++K R++P
Sbjct: 345 PPAEKKAAKALKDEQEAPYQYCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKTRVQP 404

Query: 515 SDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKG 574
             I INIGKDA +P  P PG +WKE++HD   TWLA W + IN   +KYV LAA+S +KG
Sbjct: 405 EQITINIGKDAKVPPPP-PGHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVKG 462

Query: 575 QSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE 634
           QSD +K+EKAR LK +I  IR  Y K+     + ++Q A A YLID+ ALRAGNEK +DE
Sbjct: 463 QSDFKKFEKARELKKHIEKIRKDYQKNLKHDMMVERQKATAVYLIDQFALRAGNEKGEDE 522

Query: 635 ADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGD 693
           A+TVGCC+LK ENVT + PN + F+FLGKDSI++ + V+V+L V+  +  F+K  KK GD
Sbjct: 523 AETVGCCSLKYENVTLKPPNTVVFDFLGKDSIRFYDEVQVDLQVFKNLKIFKKAPKKNGD 582

Query: 694 DLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK-DTKDGDVGEKIVVYQHA 752
           ++FD L TS LN HL   MPGLTAKVFRT+NAS T+  +LN+ +   G + EK+  Y  A
Sbjct: 583 EIFDRLTTSALNKHLANYMPGLTAKVFRTYNASYTMGCVLNEMNASGGTIAEKVKAYNDA 642

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V+  H   M ++ E++  L+     LK+   DLD
Sbjct: 643 NRKVAILCNHKRTVTAGHANAMEKMGERIKGLRYQKWRLKQQMLDLD 689



 Score = 85.9 bits (211), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 42/81 (51%), Positives = 58/81 (71%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  I++ + ++E M    + KED K VALGTSKINY+DPR+TV + K+++VPIEK F
Sbjct: 784 EKLENSINKIDQRVETMSVQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKYDVPIEKFF 843

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +K+L  KF WA+  VD D+ F
Sbjct: 844 SKALREKFEWAIKSVDEDWEF 864


>O13463_EMENI (tr|O13463) Topoisomerase I OS=Emericella nidulans PE=3 SV=1
          Length = 871

 Score =  415 bits (1066), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 217/467 (46%), Positives = 294/467 (62%), Gaps = 19/467 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRD-T 403
           P+ GDG  KWTTL HNGV+FPPPY+P    VKM Y G PVDL  + EEVA  +  M + T
Sbjct: 232 PTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFGSMLNST 291

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
            +     F++NF+ D++++L K         N V I+    CD  PI+ +          
Sbjct: 292 QHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIFQYYDAQRQEKKA 351

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK G++K R++
Sbjct: 352 LPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQ 411

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK+A +P  P  G +WKE++HD   TWLA W + IN   +KYV LAA+S +K
Sbjct: 412 PEQITINIGKEARVPPPP-EGHKWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANSDVK 469

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           GQSD +K+EKAR LK +I  IR  Y K+   + + ++Q A A YLID+ ALRAGNEK +D
Sbjct: 470 GQSDYKKFEKARELKKHIARIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGED 529

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EA+TVGCC+LK ENVT + PNK+ F+FLGKDSI++ + VEV+  V+  +  F+K  KK G
Sbjct: 530 EAETVGCCSLKYENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKKEG 589

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHA 752
           D++FD L TS LN HL + MPGLTAKVFRT+NAS T+ ++L      G+  EK+  Y  A
Sbjct: 590 DEIFDRLTTSALNKHLSQYMPGLTAKVFRTYNASHTMSELLKSMHATGNNAEKVKAYNDA 649

Query: 753 NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLD 796
           N++VAI+CNH+R+V      QM +++E++   +     LK++  DLD
Sbjct: 650 NRKVAILCNHKRTVGAVTRDQMEKMSERIKGQRYQKWRLKQMMLDLD 696



 Score = 85.1 bits (209), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 43/81 (53%), Positives = 57/81 (70%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  I++   +IE M+   + KED K VALGTSKINY+DPR+TV + K+ +VPIEK F
Sbjct: 791 EKLEASITKLQQRIENMELQAQDKEDNKEVALGTSKINYIDPRLTVVFSKKFKVPIEKFF 850

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +KSL  KF WA+  VD ++ F
Sbjct: 851 SKSLREKFEWAIKSVDENWEF 871


>A0DKX8_PARTE (tr|A0DKX8) Chromosome undetermined scaffold_55, whole genome
           shotgun sequence OS=Paramecium tetraurelia
           GN=GSPATT00018012001 PE=3 SV=1
          Length = 596

 Score =  414 bits (1064), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 231/556 (41%), Positives = 327/556 (58%), Gaps = 17/556 (3%)

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           W  L H+GV+FPP Y+ H V ++Y GK + LT +QEE+ T +A    + Y  K+ +++NF
Sbjct: 45  WRYLEHHGVLFPPFYKRHNVGLIYNGKLITLTEEQEELCTYWAQSIGSPYENKEIYRKNF 104

Query: 416 WNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXW 475
                 L+        L   DFT I ++                               +
Sbjct: 105 ----ESLMQTKFEGFQLDKADFTKIKEYLEQQRLLRLNKSDEQKKQEKLERDQRELFYGY 160

Query: 476 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGE 535
           A+VDG  E+VGN+ +E P LF+GRGEHPK G LK RI P ++ +N+   AP+P+C +PG 
Sbjct: 161 ALVDGCLERVGNYTLEQPTLFKGRGEHPKAGLLKARIFPEELTVNLSTQAPVPQCKLPGH 220

Query: 536 RWKEIRHDNTVTWL-AFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNI 594
            W +I H N VTWL ++ +  I     KYV  AA+S  K  +DK KYEKAR LK+ I  I
Sbjct: 221 SWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYEKARRLKNQIDQI 280

Query: 595 RAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPN 654
           R  YTK   S  I ++Q+  ATYLIDKLALR GNEKD+DEADTVGCC+L+VE++  +  +
Sbjct: 281 RENYTKKLQSDSIKERQLGTATYLIDKLALRVGNEKDEDEADTVGCCSLRVEHIKLKEDD 340

Query: 655 KLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPG 714
            + F+FLGKDS++Y N V++   ++  +  F K K+  D+LF  +    LN  LK+ M G
Sbjct: 341 VVAFDFLGKDSMRYNNEVKLAHQIWKNLKLFIKGKQPEDNLFSDISVDDLNDFLKKQMEG 400

Query: 715 LTAKVFRTFNASITLDDMLNKDTK-DG-DVGEKIVVYQHANKQVAIICNHQRSVSKSHDT 772
           LTAKVFRT+NAS TL   L+   K DG  V +K+  Y +ANKQVAI+CNHQ+++SK  + 
Sbjct: 401 LTAKVFRTYNASFTLQQQLDLGGKLDGHSVQQKVDFYDNANKQVAILCNHQKTISKQFEL 460

Query: 773 QMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEK------KIS 826
              ++N KL+ ++  ++EL     +                   +S  ++K      KI 
Sbjct: 461 TKKKINTKLECMKTYIQELEQHYKKKNPNEYEEEVQLEEGSQKKNSIFIKKFPGQHDKIK 520

Query: 827 QTNAKI-EKMQRDMK---TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL 882
           QT  K  EK Q+++K    KE+ K +ALGTSK NY DPRI+VA+CK H+VPIE++F+K+L
Sbjct: 521 QTIQKTQEKYQKELKGLEKKEENKEIALGTSKTNYNDPRISVAFCKVHDVPIERVFSKTL 580

Query: 883 LAKFTWAMDVDPDFRF 898
             KF WAM  D +++F
Sbjct: 581 RNKFIWAMATDSNWKF 596


>Q6C7R2_YARLI (tr|Q6C7R2) YALI0D26103p OS=Yarrowia lipolytica GN=YALI0D26103g
           PE=3 SV=1
          Length = 760

 Score =  413 bits (1062), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 212/447 (47%), Positives = 280/447 (62%), Gaps = 15/447 (3%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           D   KW TL H GV+FPP Y+P    V M Y G PV L    EEVA  +  M +TD+   
Sbjct: 130 DDSIKWETLEHKGVMFPPEYEPLPKSVLMKYDGTPVVLPHAAEEVAGFFGAMLETDHAKN 189

Query: 409 DKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXX 458
             F++NF+ND++ +L          G N  I+    CDF+ +Y                 
Sbjct: 190 PTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDMYAHFEKMREEKKAMSAAE 249

Query: 459 XXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIV 518
                             +++G KE+VGNFR+EPPGLFRGRG HPK GKLKRR+ P  I 
Sbjct: 250 KKAIKAERDKIEEPFKVCLLNGRKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEQIT 309

Query: 519 INIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDK 578
           INIGK  P+PE P  G +W E+RHDN+V WLA W++ IN  + KYV  AA+SSLKG SD 
Sbjct: 310 INIGKGVPVPEPPA-GHKWGEVRHDNSVAWLAMWHENINNSI-KYVLFAANSSLKGMSDY 367

Query: 579 EKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTV 638
           +K+EKAR LK ++  IR  Y K+  S+ + ++Q A A YLID LALRAG EK DDEADTV
Sbjct: 368 KKFEKARELKKHVATIRKDYEKELKSEAMFERQRATAMYLIDVLALRAGGEKGDDEADTV 427

Query: 639 GCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFD 697
           GCC+L+ E++T   PN ++F+FLGKDSI+Y   VEV   V+  +  F+K  KK GDD+FD
Sbjct: 428 GCCSLRYEHITLSPPNIVEFDFLGKDSIRYHQEVEVSPQVFKNLRIFKKAPKKVGDDIFD 487

Query: 698 MLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVA 757
            LD S LN HL+  MPGLTAKVFRT+NAS T+DD L     +G V EK+V +  AN+ VA
Sbjct: 488 RLDPSVLNKHLQNYMPGLTAKVFRTYNASKTMDDQLALIPNEGTVAEKLVKFNAANRAVA 547

Query: 758 IICNHQRSVSKSHDTQMTRLNEKLDEL 784
           I+CNHQ++VSK+H   + ++ ++++E+
Sbjct: 548 ILCNHQKTVSKTHGESVGKIEDRINEV 574



 Score = 79.0 bits (193), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 37/81 (45%), Positives = 56/81 (69%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E L  ++ +   ++  M+  +K KED  +VALGTSK+NY+DPR+TV + K+++VPIEK+F
Sbjct: 680 EKLRAQVEKLETRVTTMRMQLKDKEDNSSVALGTSKMNYIDPRLTVKFSKKYDVPIEKLF 739

Query: 879 NKSLLAKFTWAMD-VDPDFRF 898
            K+L  KF WA+   D D+ F
Sbjct: 740 TKTLRDKFQWAIQSADEDWEF 760


>Q2HDT9_CHAGB (tr|Q2HDT9) Putative uncharacterized protein OS=Chaetomium globosum
           GN=CHGG_01615 PE=3 SV=1
          Length = 907

 Score =  413 bits (1061), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 251/641 (39%), Positives = 343/641 (53%), Gaps = 105/641 (16%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVM-RDT 403
           P   D   KWTTL H+GV+FPP Y+  P  VK+LY G+PVDL  + EEVAT +  M   T
Sbjct: 264 PKKEDDSVKWTTLEHSGVLFPPEYERLPKNVKLLYDGQPVDLHIEAEEVATFFGSMLHST 323

Query: 404 DYMLKDKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
             +    F++NF+ D++ +L          GK   I+  K  DFT I+D           
Sbjct: 324 QNVENPVFQKNFFADFKDILKKTGGAKDKQGKPVDIKEFKKLDFTKIFDHYKALGDARKA 383

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                +   DG KEKVGNFRVEPPGLFRGRGEHPK G +K+R+ 
Sbjct: 384 RPAAEKKAEKAEKDKAEGHFMFCKWDGRKEKVGNFRVEPPGLFRGRGEHPKTGTVKKRVM 443

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  + INIGKDA +P  P PG +WK ++HDN  TWLA W + +N   +KYV LAA+S++K
Sbjct: 444 PEQVTINIGKDAKVP-APPPGHKWKAVQHDNKATWLAMWQENVNGN-YKYVMLAANSTVK 501

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-D 632
           GQ+D +K+EKAR LK +I  IRA YT++  S+ +  +Q A A YLID+ ALRAGNEKD +
Sbjct: 502 GQADFKKFEKARDLKKHIDRIRADYTRELKSEVMADRQRATAMYLIDRFALRAGNEKDTE 561

Query: 633 DEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKG 691
           +EA+TVGCC+LK E+VT   PN + F+FLGKDSI++ N   V+  V+  +  F+K  K+ 
Sbjct: 562 NEAETVGCCSLKFEHVTLREPNTVIFDFLGKDSIRFYNEFSVDRQVFKNLKVFKKSPKED 621

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK-DTKDGDVGEKIVVYQ 750
           GDD+FD L TS+LN HL   M GLTAKVFRT+NAS T+  +L K + +D  + EKI +Y 
Sbjct: 622 GDDIFDRLTTSQLNKHLSSYMTGLTAKVFRTYNASWTMSQLLQKLEVEDRTMAEKIKLYN 681

Query: 751 HANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ----------------------AVL 788
             N++VAI+CNH+R+V   H+ QM +L +++  L+                      A  
Sbjct: 682 DCNREVAILCNHKRTVGAGHEAQMEKLGDRIKGLKYQKWRTKMMMLDLDPKLKKKKGAEF 741

Query: 789 KELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQR----DMKTKED 844
            EL +DLD+A                    E +EKK ++ N K+E  ++      + KE 
Sbjct: 742 FELDSDLDQAWVEEHQQFLAKEL------QEKIEKKFAKDNEKLEADKQAKLPAKELKER 795

Query: 845 LKTVAL-------------------------GTSKINYLDPRI----------------- 862
           LK VA                           T+ +  LD RI                 
Sbjct: 796 LKAVAELEAKFKKENKTKKVEAEGKGPSVEKLTTAVEKLDERIRTLEMQSADREGNKEVA 855

Query: 863 -------------TVAWCKRHEVPIEKIFNKSLLAKFTWAM 890
                        TV +  + +VPIEK F+K+L  KF WA+
Sbjct: 856 LGTSKINYIDPRLTVVFSNKFQVPIEKFFSKTLRDKFNWAI 896


>A5E508_LODEL (tr|A5E508) DNA topoisomerase I OS=Lodderomyces elongisporus
           GN=LELG_04697 PE=3 SV=1
          Length = 849

 Score =  412 bits (1060), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 208/441 (47%), Positives = 286/441 (64%), Gaps = 9/441 (2%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           DG+ KWT+L HNGV+FPP Y+P    VK+ Y GKPV+L  + EEVA  +  M +TD+   
Sbjct: 223 DGEIKWTSLEHNGVMFPPEYEPLPSHVKLYYDGKPVNLPVEAEEVAGFFGAMVETDHAKN 282

Query: 409 DKFKENFWNDWRKLL----GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
             F++NF+ND++++L    G N  I+  +  DF+ IY +                     
Sbjct: 283 PVFQKNFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYEKKREEKKAMSREEKKRLKE 342

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                       +++G KE VGNFR+EPPGLFRGRG HPK GKLKRR+RP  + +N+ K 
Sbjct: 343 EKDRIEEPFKTCLLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVRPEQVTLNLSKG 402

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
             IPE P  G  W E+RHDN VTWLA W + I+   FKYV  AA+SS+KGQSD +K+EKA
Sbjct: 403 VKIPEPP-AGHHWAEVRHDNEVTWLAMWKENISDS-FKYVRFAANSSVKGQSDFKKFEKA 460

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 644
           R L+ ++  IR  YTK   S+ +  +Q+A A YLID  ALRAG EK +DEADTVGCC+L+
Sbjct: 461 RELRQHVDAIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLR 520

Query: 645 VENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTSK 703
            E++T + PN++ F+FLGKDSI++   VEV+  V+  +  F+KD K+ GDD+FD ++ S 
Sbjct: 521 YEHLTLKPPNQVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKDPKRPGDDIFDRINPSM 580

Query: 704 LNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQ 763
           +N  L+  M GLTAKVFRT+NAS T+ D L+    +G   EK+V +  AN+ VAI+CNHQ
Sbjct: 581 VNKQLQNYMKGLTAKVFRTYNASKTMQDQLDLIPNEGTAAEKVVKFNAANRTVAILCNHQ 640

Query: 764 RSVSKSHDTQMTRLNEKLDEL 784
           R+VSK+H   + ++N+KL EL
Sbjct: 641 RTVSKNHGNSVQKINDKLREL 661



 Score = 76.3 bits (186), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 44/123 (35%), Positives = 69/123 (56%), Gaps = 11/123 (8%)

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           + EKLD++  + KE + +L   +                 + E L+ ++     +I    
Sbjct: 737 IKEKLDKITELEKEYKKELKTGKPEIPK----------GATVEKLKTQVENMENRIVSTT 786

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMD-VDPD 895
             +K KED   V+LGTSK+NY+DPR+TV + K+ +VPIEK+F K+L  KF WA++  D D
Sbjct: 787 LQLKDKEDNSEVSLGTSKMNYIDPRLTVMFSKKFDVPIEKLFTKTLREKFKWAIESTDKD 846

Query: 896 FRF 898
           +RF
Sbjct: 847 WRF 849


>Q0UUB0_PHANO (tr|Q0UUB0) Putative uncharacterized protein OS=Phaeosphaeria
           nodorum GN=SNOG_04654 PE=3 SV=2
          Length = 887

 Score =  410 bits (1054), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 206/452 (45%), Positives = 285/452 (63%), Gaps = 16/452 (3%)

Query: 348 SSGDGQKKWTTLVHNGVIFPPPY--QPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDY 405
           + GDG KKW TL HNGV+FPP Y   P  VK++Y G PV L  + EE AT Y  M ++ +
Sbjct: 249 AKGDGSKKWDTLEHNGVVFPPEYVPLPKNVKLIYDGIPVTLQPEAEEAATFYGSMLNSTH 308

Query: 406 MLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXX 454
            +++  F +NF+ D+  +L          GK   I+  + CDF PI++            
Sbjct: 309 NVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDFKPIFEHFEADRAAKKAL 368

Query: 455 XXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRP 514
                               + + DG K+KVGNFRVEPPGLFRGRGEHPK G++K+R+ P
Sbjct: 369 PAAEKKALKAEKDAAEAEYMFCMWDGRKQKVGNFRVEPPGLFRGRGEHPKTGRIKKRVAP 428

Query: 515 SDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKG 574
             I INIG++A +P  P  G RWKE++HD+  TWLA W + IN   +KYV LAA+S +KG
Sbjct: 429 EQITINIGENAKVPPPPA-GHRWKEVKHDHEGTWLAMWQENING-AYKYVMLAANSDIKG 486

Query: 575 QSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE 634
           QSD +K+EKAR LK +I  IR  Y ++  S+ +  +Q A A YLID+ ALRAGNEK +DE
Sbjct: 487 QSDFKKFEKARELKKHIDRIRQDYRRELKSEKMVDRQRATAIYLIDQFALRAGNEKGEDE 546

Query: 635 ADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKG-GD 693
           ADTVGCC+LK +++T   P  + F+FLGKDSI++ + V+V+  V+  +  F+K+ K  GD
Sbjct: 547 ADTVGCCSLKFQHITLRPPETVIFDFLGKDSIRFYDEVKVDAQVFKNLKIFKKEPKTVGD 606

Query: 694 DLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHAN 753
           D+FD L TS LN HL   MPGLTAKVFRT+NAS T+  +L      G + EK+  Y  AN
Sbjct: 607 DIFDRLTTSALNKHLTSYMPGLTAKVFRTYNASYTMARLLKSLKATGTIQEKVKAYNDAN 666

Query: 754 KQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           ++VAI+CNH+R+V+ +H   + ++NEK+  L+
Sbjct: 667 REVAILCNHKRTVAATHGASIDKMNEKIKGLR 698



 Score = 86.7 bits (213), Expect = 8e-15,   Method: Compositional matrix adjust.
 Identities = 44/81 (54%), Positives = 57/81 (70%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  I + N +IE M+  M+ KE  K VALGTSKINY+DPR+TV + K+ +VPIEK F
Sbjct: 807 EKLEANIDKINQRIENMRIQMEDKEGNKEVALGTSKINYIDPRLTVVFSKKFDVPIEKFF 866

Query: 879 NKSLLAKFTWAM-DVDPDFRF 898
           +K+L  KF WA+  VD D+ F
Sbjct: 867 SKTLREKFDWAIKSVDEDWEF 887


>Q59XR0_CANAL (tr|Q59XR0) Likely DNA topoisomerase I OS=Candida albicans GN=TOP1
           PE=3 SV=1
          Length = 780

 Score =  410 bits (1054), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 211/442 (47%), Positives = 282/442 (63%), Gaps = 9/442 (2%)

Query: 350 GDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYML 407
           GDG  KW TL HNGV+FPPPY+P    VK+ Y  KPV+L  + EEVA  Y  M +TD+  
Sbjct: 153 GDGYIKWQTLEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAK 212

Query: 408 KDKFKENFWNDWRKLL----GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXX 463
              F++NF+ND+ ++L    G    I+  +  DF+ +Y                      
Sbjct: 213 NPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFEKLREEKKAMSREEKKRIK 272

Query: 464 XXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGK 523
                         ++G KE VGNFR+EPPGLFRGRG HPK GKLKRR+ P  + +N+GK
Sbjct: 273 EEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGK 332

Query: 524 DAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEK 583
           DA IPE P  G +W EIRHDN VTWLA W + I+  L KYV  A +SS+KGQSD +K+E 
Sbjct: 333 DAKIPEPP-AGHQWGEIRHDNEVTWLAMWKENISDSL-KYVRFANNSSVKGQSDFKKFET 390

Query: 584 ARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 643
           AR L+D++ +IR  YTK   S+ +  +Q+A A YLID  ALRAG EK +DEADTVGCC+L
Sbjct: 391 ARKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSL 450

Query: 644 KVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTS 702
           + E+VT + PNK+ F+FLGKDSI++   VEV+  V+  +  F+K  K+ GDDLFD ++ S
Sbjct: 451 RYEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDLFDRINPS 510

Query: 703 KLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNH 762
            +N  L+  M GLTAKVFRT+NAS T+ D ++    +G V EK+  +  AN+ VAI+CNH
Sbjct: 511 LVNRQLQNYMKGLTAKVFRTYNASKTMQDQIDIIENEGTVAEKVAKFNAANRTVAILCNH 570

Query: 763 QRSVSKSHDTQMTRLNEKLDEL 784
           QR+VSK+H   + R+N+KL E 
Sbjct: 571 QRTVSKTHGDSVQRINDKLKEF 592



 Score = 75.9 bits (185), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 44/123 (35%), Positives = 71/123 (57%), Gaps = 11/123 (8%)

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           + +KLD++  + KE + +L   +               N + E L+++I     KI  + 
Sbjct: 668 IKDKLDKIDELEKEYQKELKTGKPIVTK----------NATVEKLKQQIETLENKILNVS 717

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMD-VDPD 895
             +K KED   V+LGTSK+NY+DPR+ V + K+ +VPIEK+F K+L  KF WA++  D +
Sbjct: 718 IQLKDKEDNSEVSLGTSKMNYIDPRLIVMFSKKFDVPIEKLFTKTLREKFIWAIESADEN 777

Query: 896 FRF 898
           +RF
Sbjct: 778 WRF 780


>Q59WV6_CANAL (tr|Q59WV6) Likely DNA topoisomerase I OS=Candida albicans GN=TOP1
           PE=3 SV=1
          Length = 780

 Score =  409 bits (1051), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 211/442 (47%), Positives = 282/442 (63%), Gaps = 9/442 (2%)

Query: 350 GDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYML 407
           GDG  KW TL HNGV+FPPPY+P    VK+ Y  KPV+L  + EEVA  Y  M +TD+  
Sbjct: 153 GDGYIKWQTLEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAK 212

Query: 408 KDKFKENFWNDWRKLL----GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXX 463
              F++NF+ND+ ++L    G    I+  +  DF+ +Y                      
Sbjct: 213 NPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFEKLREEKKAMSREEKKRIK 272

Query: 464 XXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGK 523
                         ++G KE VGNFR+EPPGLFRGRG HPK GKLKRR+ P  + +N+GK
Sbjct: 273 EEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGK 332

Query: 524 DAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEK 583
           DA IPE P  G +W EIRHDN VTWLA W + I+  L KYV  A +SS+KGQSD +K+E 
Sbjct: 333 DAKIPEPP-AGHQWGEIRHDNEVTWLAMWKENISDSL-KYVRFANNSSVKGQSDFKKFET 390

Query: 584 ARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 643
           AR L+D++ +IR  YTK   S+ +  +Q+A A YLID  ALRAG EK +DEADTVGCC+L
Sbjct: 391 ARKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSL 450

Query: 644 KVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTS 702
           + E+VT + PNK+ F+FLGKDSI++   VEV+  V+  +  F+K  K+ GDDLFD ++ S
Sbjct: 451 RYEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDLFDRINPS 510

Query: 703 KLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNH 762
            +N  L+  M GLTAKVFRT+NAS T+ D ++    +G V EK+  +  AN+ VAI+CNH
Sbjct: 511 LVNRQLQNYMKGLTAKVFRTYNASKTMQDQIDIIENEGTVAEKVAKFNAANRTVAILCNH 570

Query: 763 QRSVSKSHDTQMTRLNEKLDEL 784
           QR+VSK+H   + R+N+KL E 
Sbjct: 571 QRTVSKTHGDSVQRINDKLKEF 592



 Score = 75.9 bits (185), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 44/123 (35%), Positives = 71/123 (57%), Gaps = 11/123 (8%)

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           + +KLD++  + KE + +L   +               N + E L+++I     KI  + 
Sbjct: 668 IKDKLDKIDELEKEYQKELKTGKPIVTK----------NATVEKLKQQIETLENKILNVS 717

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMD-VDPD 895
             +K KED   V+LGTSK+NY+DPR+ V + K+ +VPIEK+F K+L  KF WA++  D +
Sbjct: 718 IQLKDKEDNSEVSLGTSKMNYIDPRLIVMFSKKFDVPIEKLFTKTLREKFIWAIESADEN 777

Query: 896 FRF 898
           +RF
Sbjct: 778 WRF 780


>Q4V7M4_XENLA (tr|Q4V7M4) MGC115546 protein OS=Xenopus laevis GN=top1 PE=2 SV=1
          Length = 503

 Score =  409 bits (1050), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 225/509 (44%), Positives = 308/509 (60%), Gaps = 16/509 (3%)

Query: 400 MRDTDYMLKDKFKENFWNDWRK--LLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXX 457
           M D +Y  K+ F+ NF+ DWRK   L +  VI +L  CDFT ++ +              
Sbjct: 1   MLDHEYTTKEIFRNNFFVDWRKEMTLEEKMVITDLDKCDFTEMFTYYKGKMEEKKNKSKE 60

Query: 458 XXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDI 517
                            +  +D  +EK+GNF++EPP LFRGRG+HPK G LK+RI P DI
Sbjct: 61  DKLKIKEENEKLLEEYGYCAMDHHREKIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDI 120

Query: 518 VINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSD 577
           +IN  KD+ IPE P PG +WKE+RHDNTVTWLA W + +   + KY+ L A+S LKG+ D
Sbjct: 121 IINCSKDSKIPEPP-PGHKWKEVRHDNTVTWLASWTENVQGSV-KYIMLNANSKLKGEKD 178

Query: 578 KEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-AD 636
            EKYE AR LK +   IR  Y ++F SK++  +Q AVA Y IDKLALRAGNEK++ E AD
Sbjct: 179 WEKYEIARKLKHHAEKIRKTYRENFKSKEMKVRQRAVALYFIDKLALRAGNEKEEGESAD 238

Query: 637 TVGCCTLKVENVTRE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKG 691
           TVGCC+L+VE++          + ++F+FLGKDSI+Y N V VE  V+  +  F ++K+ 
Sbjct: 239 TVGCCSLRVEHIKLYPELDGEKHVVEFDFLGKDSIRYYNKVPVEKQVFKNLQLFMENKEE 298

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQ 750
           GDDLFD L+T  LN HL+ LM GLTAKVFRT+NASITL   L + T  +  +  KI+ Y 
Sbjct: 299 GDDLFDRLNTPLLNKHLQSLMEGLTAKVFRTYNASITLQQQLQELTDPEESIPAKILSYN 358

Query: 751 HANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXX 810
            AN+ VAI+CNHQR+  K+ D  M  L  K+D      KE      +             
Sbjct: 359 RANRAVAILCNHQRAPPKTFDQSMANLKSKID----AKKEQILLAKKELKEAKKEAKEKD 414

Query: 811 XXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRH 870
               N   E+ ++ + +T  ++ +M+     +E+ K +AL TSK+NYLDPRI+VAWCK+ 
Sbjct: 415 SEKLNKVVESKKRAVQRTEEQLMRMEVQATDREENKQIALSTSKLNYLDPRISVAWCKKW 474

Query: 871 EVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
            V +EKI+NK+   KF WA+D+ + DF F
Sbjct: 475 TVGLEKIYNKTYRDKFAWAIDMTETDFIF 503


>A7SLG4_NEMVE (tr|A7SLG4) Predicted protein OS=Nematostella vectensis
           GN=v1g122680 PE=3 SV=1
          Length = 502

 Score =  407 bits (1047), Expect = e-111,   Method: Compositional matrix adjust.
 Identities = 227/511 (44%), Positives = 319/511 (62%), Gaps = 21/511 (4%)

Query: 400 MRDTDYMLKDKFKENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXX 457
           M + DY  K+ F +NF++DWRK + +     I++LK+CDF  ++ +              
Sbjct: 1   MLEHDYTSKEIFNKNFFSDWRKEMTEEERKHIKDLKNCDFKEMHKYFEMKNEERKNMTKE 60

Query: 458 XXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDI 517
                            + ++D  K++VGNF++EPPGLFRGRG+HPK GKLK+R+ P ++
Sbjct: 61  EKLEIKKKNEEILNEYGFCMMDHHKQRVGNFKIEPPGLFRGRGDHPKQGKLKKRVMPEEV 120

Query: 518 VINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSD 577
            INIGKDA +P+ P  G +WK++  D+TVTWLA W + I    +KYV L  +S LKG+ D
Sbjct: 121 TINIGKDAKVPD-PPAGHKWKKVICDDTVTWLACWIENIQGS-YKYVMLNPTSRLKGEKD 178

Query: 578 KEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADT 637
             KYE AR LK+ +  IR  Y KD+ SK++  +Q  VA Y IDKLALRAG+EKDDD ADT
Sbjct: 179 WRKYETARKLKECVDKIREDYRKDWKSKEMRLRQRGVALYFIDKLALRAGHEKDDDTADT 238

Query: 638 VGCCTLKVENVT--REAPNK---LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGG 692
           VGCC+L+VE++    E  +K   ++F+FLGKDS++Y N V +E   +  +  F + K+ G
Sbjct: 239 VGCCSLRVEHIKLHEEWEDKECVVEFDFLGKDSVRYRNFVPIEKRAFKNMKLFMEGKQEG 298

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQH 751
           DDLFD L T+ +N +L ELM GL+AKVFRTFNAS+TL D L K T   D V  KI+ Y  
Sbjct: 299 DDLFDRLTTTSVNKYLSELMEGLSAKVFRTFNASLTLQDQLQKLTNPEDNVNAKILSYNR 358

Query: 752 ANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXX 811
           AN+ VAI+CNHQR+  K+ +  M+ L  K+ + +  +KE + +L   R            
Sbjct: 359 ANRAVAILCNHQRTAPKTFEKSMSNLQLKISDKKKTVKEAKKELKALRVKAKESKSES-- 416

Query: 812 XXXNLSSEALEKKISQTN---AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCK 868
                +++A+EKK +Q      ++ K++     KE+ K +ALGTSK+NYLDPRITVAWCK
Sbjct: 417 -----NNKAVEKKKAQVQRLEEQLFKLEVTATDKEENKEIALGTSKLNYLDPRITVAWCK 471

Query: 869 RHEVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
           + EVPIEK +NK+   KF WA+D+   DF F
Sbjct: 472 KFEVPIEKAYNKTQREKFAWAIDMAGEDFVF 502


>A3LUX2_PICST (tr|A3LUX2) DNA topoisomerase I OS=Pichia stipitis GN=TOP1 PE=3
           SV=2
          Length = 780

 Score =  405 bits (1040), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 209/441 (47%), Positives = 280/441 (63%), Gaps = 9/441 (2%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           DG +KW TL HNGV+FPP Y+P    VK+ Y GKPV L+ + EEVA  Y  M +TD+   
Sbjct: 152 DGVQKWETLEHNGVLFPPEYEPLPSHVKLYYDGKPVKLSLEAEEVAGFYGAMLETDHAKN 211

Query: 409 DKFKENFWNDWRKLL----GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
             F++NF+ D+  ++    G +  I++ +  DF+ I+                       
Sbjct: 212 PVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFEKLREEKKLLTKDQKKAMKE 271

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                       + +G KE VGNFRVEPPGLFRGRG HP+ GKLKRR+ P  + +NIG  
Sbjct: 272 EKERIEEPYKTCLFNGHKELVGNFRVEPPGLFRGRGAHPRTGKLKRRVYPEMVTLNIGAG 331

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
           A IPE P PG  W EI++DNTVTWLA W + I    FKYV  AASSS+KG SD +K+E A
Sbjct: 332 AKIPEAP-PGHSWGEIKNDNTVTWLAMWRENIADS-FKYVRFAASSSIKGVSDFKKFETA 389

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 644
           R L+ ++  IR  YTK   S+ +  +Q+A A YLID  ALRAG EK DDEADTVGCC+L+
Sbjct: 390 RRLRSHVDAIRKDYTKMLKSELMQDRQMASAIYLIDVFALRAGGEKGDDEADTVGCCSLR 449

Query: 645 VENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTSK 703
            E++T + PNK+ F+FLGKDSI++   VEV+  V+  +  F+K  K+ GDDLFD ++ + 
Sbjct: 450 YEHITLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKAPKQPGDDLFDRINPTM 509

Query: 704 LNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQ 763
           LN  L+  M GLTAKVFRT+NAS T+ D L+    +G V EK+V +  AN+ VAI+CNHQ
Sbjct: 510 LNKQLQNYMKGLTAKVFRTYNASKTMQDQLDLIPNEGTVAEKVVKFNAANRTVAILCNHQ 569

Query: 764 RSVSKSHDTQMTRLNEKLDEL 784
           R+VSK H + + ++N+KL EL
Sbjct: 570 RTVSKGHGSSVQKINDKLKEL 590


>A6S3Q9_BOTFB (tr|A6S3Q9) Putative uncharacterized protein OS=Botryotinia
           fuckeliana (strain B05.10) GN=BC1G_07231 PE=3 SV=1
          Length = 912

 Score =  402 bits (1032), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 246/637 (38%), Positives = 347/637 (54%), Gaps = 95/637 (14%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTD 404
           P   D   KW TL HNGV+FPP Y+P    VK+ Y G P+ L+ + EE+A  +  M ++ 
Sbjct: 269 PKKEDDSIKWETLQHNGVVFPPEYEPLPKNVKLRYDGIPLTLSLESEEIAGFFGAMLNST 328

Query: 405 YMLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
           + +++  F++NF+ D+   +          G    I++    DF PI+++          
Sbjct: 329 HNVENPTFQKNFFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIFEYYDGKSTERKA 388

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                  I DG KE VGNFRVEPPGLFRGRGEHPK GK+K R+ 
Sbjct: 389 RSAAEKKAEKALKDEAEAPYKTCIWDGRKEDVGNFRVEPPGLFRGRGEHPKTGKVKLRVT 448

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGKDA +P  P  G +WK I+HDN  TWLA W + IN   +KYV LAA SS+K
Sbjct: 449 PEQITINIGKDATVP-SPPEGHKWKAIQHDNKATWLAMWQENIN-GAYKYVMLAAKSSIK 506

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-D 632
           GQSD +K+EKAR LK++I  IR  YT+D  ++ +  +Q A A YLIDK ALRAGNEKD +
Sbjct: 507 GQSDFKKFEKARELKEHIDRIRKDYTQDLKAELMADRQRATAVYLIDKFALRAGNEKDAE 566

Query: 633 DEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKG 691
           +EA+TVGCC+LK E+VT + PN + F+FLGKDSI++ + V V+  V+  +  F+K  KK 
Sbjct: 567 NEAETVGCCSLKYEHVTLKPPNTVIFDFLGKDSIRFYDEVTVDPQVFKNLKIFKKAPKKN 626

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVG--EKIVVY 749
           GDD+FD L+T++LN HL   MPGL+AKVFRT+NAS T+ D+L K  K+ D+   EKI +Y
Sbjct: 627 GDDIFDRLNTTQLNKHLTNYMPGLSAKVFRTYNASWTMSDLLKK-LKNSDISMQEKIKLY 685

Query: 750 QHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLDRARXXXXXXX 806
              N++VAI+CNH+R+V  SH+  + ++++ +  L+     LK++  D+D  +       
Sbjct: 686 NDCNRKVAILCNHKRTVGASHEAAIEKMDDAVKGLKYQKWRLKQMILDIDPKQKKKKGAD 745

Query: 807 XXXXXXXXNLS----SEA---------LEKKISQTNAK-IEKMQRDMKTKE--------- 843
                   + S     +A         +EKK ++ N K + + Q++MKTKE         
Sbjct: 746 WFALDEELDESWIQEHQAFLVAQERIKIEKKFAKENEKLVSEGQKEMKTKELNERLHAAT 805

Query: 844 DLK-------------------TVALGTSKINYLDPRITVAWCKRH-------------- 870
           DL+                   +V    + I  +D RI     KR               
Sbjct: 806 DLEKKFKKENKTKKVEAEGKGPSVDKFEANITKIDERIANMLLKREDREGNKEVALGTSK 865

Query: 871 ----------------EVPIEKIFNKSLLAKFTWAMD 891
                           +VPIEK F+K+L  KF WA+D
Sbjct: 866 INYIDPRLTVVFSQKFDVPIEKFFSKTLREKFAWAID 902


>A7EXF7_SCLS1 (tr|A7EXF7) Putative uncharacterized protein OS=Sclerotinia
           sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
           GN=SS1G_10018 PE=3 SV=1
          Length = 911

 Score =  402 bits (1032), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 245/637 (38%), Positives = 350/637 (54%), Gaps = 95/637 (14%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTD 404
           P   D   KW TL HNGV+FPP Y+P    VK+ Y G P+ L+ + EE+A  +  M ++ 
Sbjct: 268 PKKEDDSIKWETLQHNGVVFPPEYEPLPKNVKLGYDGIPLTLSLESEEIAGFFGAMLNST 327

Query: 405 YMLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
           + +++  F++NF+ D+   +          G    I++    DF PI+++          
Sbjct: 328 HNVENPTFQKNFFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIFEYYDGKSTERKA 387

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                  I DG KE VGNFRVEPPGLFRGRGEHPK GK+K R+ 
Sbjct: 388 RSAAEKKAEKAAKDEAEAPYKTCIWDGRKEDVGNFRVEPPGLFRGRGEHPKTGKVKLRVT 447

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK+A +P  P  G +WK I+HDN  TWLA W + IN   +KYV LAA SS+K
Sbjct: 448 PEQITINIGKEATVP-SPPEGHKWKAIQHDNKATWLAMWQENIN-GAYKYVMLAAKSSIK 505

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-D 632
           GQSD +K+EKAR LK++I  IR  YT+D  ++ +  +Q A A YLIDK ALRAGNEKD +
Sbjct: 506 GQSDYKKFEKARELKEHIDRIRKDYTQDLHAELMADRQRATAVYLIDKFALRAGNEKDAE 565

Query: 633 DEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKD-KKG 691
           +EA+TVGCC+LK E+VT + PN + F+FLGKDSI++ + V V+  V+  +  F+K  KK 
Sbjct: 566 NEAETVGCCSLKYEHVTLKPPNTVIFDFLGKDSIRFYDEVTVDPQVFKNLKIFKKAPKKN 625

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVG--EKIVVY 749
           GDD+FD L+T++LN HL   MPGL+AKVFRT+NAS T+ D+L K  K+ D+   EKI +Y
Sbjct: 626 GDDIFDRLNTTQLNKHLTNYMPGLSAKVFRTYNASWTMSDLLKK-LKNSDISMQEKIKLY 684

Query: 750 QHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAV---LKELRTDLDRARXXXXXXX 806
              N++VAI+CNH+R+V  SH+  + ++++ +  L+     LK++  DLD  +       
Sbjct: 685 NDCNRKVAILCNHKRTVGASHEAAIEKMDDAVKGLKYQKWRLKQMILDLDPKQKKKKGAD 744

Query: 807 XXXXXXXXN-----------LSSE--ALEKKISQTNAK-IEKMQRDMKTKE--------- 843
                   +           ++ E   +EKK ++ N K + + Q++MKTKE         
Sbjct: 745 WFALDEELDEAWIQEHQAFLVAQERIKIEKKFAKENEKLVSEGQKEMKTKELNERLQAAT 804

Query: 844 DLK-------------------TVALGTSKINYLDPRI---------------------- 862
           DL+                   +V    + I  +D RI                      
Sbjct: 805 DLEKKFKKENKSKKVEAEGKGSSVEKFEANITKIDERIANMLLKREDREGNKEVALGTSK 864

Query: 863 --------TVAWCKRHEVPIEKIFNKSLLAKFTWAMD 891
                   TV + ++ +VPIEK F+K+L  KF WA+D
Sbjct: 865 INYIDPRLTVVFSQKFDVPIEKFFSKTLREKFAWAID 901


>B2AY06_PODAN (tr|B2AY06) Predicted CDS Pa_1_9460 OS=Podospora anserina PE=4 SV=1
          Length = 904

 Score =  401 bits (1030), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 209/455 (45%), Positives = 286/455 (62%), Gaps = 18/455 (3%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMY-AVMRDT 403
           P   D   KWTTL HNGV+FPP Y+P    VK++Y G PV+L  D EEVAT + A++  T
Sbjct: 261 PKKEDDSIKWTTLEHNGVLFPPAYEPLPKDVKLIYDGTPVNLHVDAEEVATFFGAMLHST 320

Query: 404 DYMLKDKFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
             +    F++NF+ D+R +L          GK   I+     DFT I+++          
Sbjct: 321 QNVENPTFQKNFFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIFEYYKGLSEAKKA 380

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                +   DG KEKVGNFRVEPPGLFRGRGEHPK G +K+R+ 
Sbjct: 381 RPAAEKKAEKAEKDKFEAPYMYCKWDGRKEKVGNFRVEPPGLFRGRGEHPKTGTVKKRVM 440

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  + INIGK+A +P+ P  G +WK ++HDN  TWLA W + +N   +KYV LAA+S++K
Sbjct: 441 PEQVTINIGKEAKVPDPPA-GHKWKAVQHDNKATWLAMWQENVNGN-YKYVMLAANSTVK 498

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-D 632
           GQ+D +K+EKAR L  +I  IRA YT +  S+ + ++Q A A YLIDK ALRAGNEKD +
Sbjct: 499 GQADYKKFEKARELNKHIARIRADYTAELKSEIMAERQRATAMYLIDKFALRAGNEKDTE 558

Query: 633 DEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKG- 691
           +EA+TVGCC+LK E+VT   PN + F+FLGKDSI++ N   VE  V+  +  F+K  K  
Sbjct: 559 NEAETVGCCSLKFEHVTLREPNTVIFDFLGKDSIRFYNEFTVERQVFKNLKLFKKPPKAD 618

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK-DTKDGDVGEKIVVYQ 750
           GDD+FD L TS+LN HL   MPGLTAKVFRT+NAS T+  +L     ++  + EKI +Y 
Sbjct: 619 GDDIFDRLTTSQLNKHLSNYMPGLTAKVFRTYNASHTMSTLLQSLSVENRTMAEKIKLYN 678

Query: 751 HANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQ 785
             N++VA+ICNH+R+V  +H+ QM +L +++  L+
Sbjct: 679 DCNREVAVICNHKRTVGAAHEAQMEKLADRIKGLK 713



 Score = 74.3 bits (181), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 35/73 (47%), Positives = 51/73 (69%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E LE  +S+ + +I+ ++     +E  K VALGTSKINY+DPR+TV + K+  VPIEK F
Sbjct: 822 EKLEAAVSKFDDRIKTLELQCADREGNKEVALGTSKINYIDPRLTVVFAKKFNVPIEKFF 881

Query: 879 NKSLLAKFTWAMD 891
           +K+L  KF WA++
Sbjct: 882 SKTLRDKFKWAIE 894


>Q6FVE9_CANGA (tr|Q6FVE9) Similar to uniprot|P04786 Saccharomyces cerevisiae
           YOL006c TOP1 DNA topoisomerase I OS=Candida glabrata
           GN=CAGL0E02431g PE=3 SV=1
          Length = 717

 Score =  400 bits (1027), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 207/440 (47%), Positives = 285/440 (64%), Gaps = 11/440 (2%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KWTTL HNGV+FPPPY+  P  VK+ Y+G PVDL  + EEVA  +A + +T +     F+
Sbjct: 92  KWTTLEHNGVLFPPPYEALPSHVKLYYEGNPVDLPLEAEEVAGFFAHLLETPHAQNPVFQ 151

Query: 413 ENFWNDWRKLLG-----KNHV-IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXX 466
           +NF+ D++ +L      +N + I++    DF+ ++D+                       
Sbjct: 152 KNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSAMHDYFVQLKEEKKSMTAMQKKEIRLER 211

Query: 467 XXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAP 526
                   +  +DG +E+VGNF+VEPP LFRGRG HPK GKLKRRIRP DIV+N+G+ AP
Sbjct: 212 EKFEEKYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRIRPEDIVLNLGEGAP 271

Query: 527 IPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARM 586
           IP  P  G +W EIRHDNTV WLA W + I    FKYV LAA+SSLKGQSD +K+EKAR 
Sbjct: 272 IPPPP-SGHQWGEIRHDNTVQWLAMWRENIFGS-FKYVRLAANSSLKGQSDFKKFEKARE 329

Query: 587 LKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 646
           LK +I  IR  Y  +F SK + ++Q AVA YLID  ALRAG EK ++EADTVGCC+L+ E
Sbjct: 330 LKKHIDRIRKEYRNNFKSKLMVERQKAVAVYLIDVFALRAGGEKSEEEADTVGCCSLRYE 389

Query: 647 NVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSKLN 705
           ++T + PN + F+FLGKDSI++   V+V+  V+  +  F+K  K+ G  LFD LD S LN
Sbjct: 390 HITLKPPNTVIFDFLGKDSIRFYQEVQVDPKVFKNLALFKKPPKQPGHQLFDRLDPSLLN 449

Query: 706 AHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRS 765
             L+  M GLTAKVFRT+NAS T+ + L+    +G V EK++ Y  AN+ VAI+CNHQR+
Sbjct: 450 KFLQNYMTGLTAKVFRTYNASKTMQEQLDLIPNEGSVAEKLLKYNAANRTVAILCNHQRT 509

Query: 766 VSKSHDTQMTRLNEKLDELQ 785
           V+  H   + + +++++E +
Sbjct: 510 VTAGHAKSVAKSSDRIEEFK 529



 Score = 84.0 bits (206), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 42/83 (50%), Positives = 58/83 (69%), Gaps = 1/83 (1%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E LEK I + + +I   Q  ++ +E    V+LGTSKINY+DPR++V +CK++ VPIEK
Sbjct: 635 SVEKLEKAIERLDQRISTSQVQLQDREANSEVSLGTSKINYIDPRLSVVFCKKYGVPIEK 694

Query: 877 IFNKSLLAKFTWAMD-VDPDFRF 898
           IF KSL  KF WA++ VD  +RF
Sbjct: 695 IFTKSLREKFKWAIESVDETWRF 717


>Q6BLX2_DEBHA (tr|Q6BLX2) DEHA2F09988p OS=Debaryomyces hansenii GN=DEHA2F09988g
           PE=3 SV=2
          Length = 789

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 205/442 (46%), Positives = 279/442 (63%), Gaps = 9/442 (2%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           DG++KW +L HNGVIFPP Y+P    VK+ Y GKPVDL  + EEVA  +  M +TD+   
Sbjct: 163 DGEQKWESLEHNGVIFPPDYEPLPSHVKLYYDGKPVDLPLEAEEVAGFFGAMAETDHAKN 222

Query: 409 DKFKENFWNDWRKLL----GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXX 464
             F++NF+ D+ K+L    G N  I +    DF+ ++                       
Sbjct: 223 PTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSKDEKKAIKA 282

Query: 465 XXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKD 524
                       +++G KE+VGNFR+EPPGLFRGRG HPK GKLKRR+ P D+ +N+ + 
Sbjct: 283 EKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEDVTLNLSEG 342

Query: 525 APIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 584
             IPE P  G +W E+RHDNTV+WLA W + I    FKYV  AA+SS+KG SD +K+E +
Sbjct: 343 CKIPEPP-QGHKWAEVRHDNTVSWLAMWKENIADS-FKYVRFAANSSIKGLSDFKKFETS 400

Query: 585 RMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 644
           R L+ +I  IR  YTK      +  +Q+A A YLID  ALRAG EK DDEADTVGCC+L+
Sbjct: 401 RKLRYHIDEIRKDYTKMLKDPLMQNRQMATACYLIDIFALRAGGEKGDDEADTVGCCSLR 460

Query: 645 VENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDMLDTSK 703
            E++T + PNK+ F+FLGKDSI++   VEVE  V+  +  F+K  K+ GDDLFD +    
Sbjct: 461 YEHITLKPPNKVIFDFLGKDSIRFYQEVEVEKQVFKNLRIFKKPPKQPGDDLFDRISPPL 520

Query: 704 LNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQ 763
           LN   +  M GLTAKVFRT+NAS T+ D L+    +G V EK+V +  AN+ VAI+CNHQ
Sbjct: 521 LNKQFQNYMKGLTAKVFRTYNASKTMQDQLDLIPNEGTVAEKVVKFNAANRTVAILCNHQ 580

Query: 764 RSVSKSHDTQMTRLNEKLDELQ 785
           R+VSK+H + + ++++KL EL+
Sbjct: 581 RTVSKTHGSSVQKIHDKLKELE 602



 Score = 70.9 bits (172), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 35/85 (41%), Positives = 56/85 (65%), Gaps = 1/85 (1%)

Query: 815 NLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPI 874
           +++ E L+ ++     +I      +K KED   V+LGTSK+NY+DPR+TV + K+  VPI
Sbjct: 705 SVTVEKLKSQVDTLTNRILNTTFQLKDKEDNSEVSLGTSKMNYIDPRLTVMFSKKFNVPI 764

Query: 875 EKIFNKSLLAKFTWAMD-VDPDFRF 898
           EK+F K+L  KF WA++  D +++F
Sbjct: 765 EKLFTKTLRDKFNWAIESADENWKF 789


>A4R0K7_MAGGR (tr|A4R0K7) Putative uncharacterized protein OS=Magnaporthe grisea
           GN=MGG_09917 PE=3 SV=1
          Length = 906

 Score =  397 bits (1019), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 218/470 (46%), Positives = 285/470 (60%), Gaps = 22/470 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVM-RDT 403
           P   D   KW TL HNGV+FPP Y+P    VK+ Y G P+ L  + EEVAT +  M   T
Sbjct: 262 PKKEDDSIKWNTLEHNGVLFPPDYEPLPKNVKLYYNGIPLQLHPEAEEVATFFGSMLHST 321

Query: 404 DYMLKDKFKENFWNDWRKLLGK---------NHV-IQNLKDCDFTPIYDWCXXXXXXXXX 453
             +    F +NF+  ++  L K         N V I+  +  DF PI+            
Sbjct: 322 QNVENPTFIKNFFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIFQHFQAQSEAKKA 381

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                +   DG KEKVGNFRVEPP LFRGRGEHPK G +K R+ 
Sbjct: 382 RSKEEKKAEKEARDKMEEPYKYCKWDGRKEKVGNFRVEPPALFRGRGEHPKTGTIKERVP 441

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  + INIGK A +PE P  G +WK ++HDN  TWLA W + +N   +KYV LAA+S++K
Sbjct: 442 PEAVTINIGKGAKVPEPPA-GHKWKAVQHDNKATWLAMWQENVNGN-YKYVMLAANSAVK 499

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-D 632
           GQ+D +K+EKAR LK +I  IRA YT++  S+ +  +Q A A Y IDKLALRAGNEKD +
Sbjct: 500 GQADFKKFEKARELKKHIDRIRADYTRELRSEIMADRQRATAMYFIDKLALRAGNEKDTE 559

Query: 633 DEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKK-G 691
           +EA+TVGCC+LKVENV+ + PNK+  +FLGKDSI++E  VEV+  V+  +  F+K  K  
Sbjct: 560 NEAETVGCCSLKVENVSLQPPNKVFLDFLGKDSIRFEQEVEVDAQVFKNLKMFKKAPKVE 619

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK--DTKDGDVGEKIVVY 749
           GDD+FD L TS+LN HL   MPGLTAKVFRT+NAS T+  +L K    K+    EK+ +Y
Sbjct: 620 GDDIFDRLTTSQLNKHLSSYMPGLTAKVFRTYNASYTMSTLLQKLHSKKNISDAEKVKIY 679

Query: 750 QHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDEL---QAVLKELRTDLD 796
              N+QVAI+CNH+RSV  SHD QM +L +++  L   Q   K +  DLD
Sbjct: 680 NDCNRQVAILCNHKRSVGASHDAQMKKLGDRILGLKYQQWRTKMMMIDLD 729



 Score = 77.0 bits (188), Expect = 7e-12,   Method: Compositional matrix adjust.
 Identities = 34/75 (45%), Positives = 52/75 (69%)

Query: 816 LSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIE 875
           ++ E LE+++ + + +I  M+     ++  K VALGTSKINY+DPR+TV +C +  VPIE
Sbjct: 821 VTVEKLEQQVKKLDERIRTMELQAADRDGNKEVALGTSKINYIDPRLTVVFCNKMNVPIE 880

Query: 876 KIFNKSLLAKFTWAM 890
           K F+K+L  KF WA+
Sbjct: 881 KFFSKTLREKFNWAI 895


>Q7S0F7_NEUCR (tr|Q7S0F7) DNA topoisomerase I OS=Neurospora crassa GN=NCU09118
           PE=3 SV=2
          Length = 874

 Score =  393 bits (1010), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 207/447 (46%), Positives = 284/447 (63%), Gaps = 18/447 (4%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKD-KF 411
           KWTTL HNGVIFP  YQ  P  VK+LY G PV+L  + EE AT +  M ++   +++  F
Sbjct: 239 KWTTLEHNGVIFPEDYQRLPKDVKLLYDGTPVELDIEAEEAATFFGFMLNSTVNVENPTF 298

Query: 412 KENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           ++NF+ D++++L          GK   I+  +  DF+ ++ +                  
Sbjct: 299 QKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWAYKDAQTKAKNARSSAEKKA 358

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +   DG KEKVGN RVE PGLFRGRG+HPK G +K+R+ P  I INI
Sbjct: 359 EKAERDKRDAPYLYCKWDGRKEKVGNPRVEIPGLFRGRGDHPKTGCIKKRVLPEQITINI 418

Query: 522 GKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKY 581
           GK+A +PE P  G +WK ++HDN  TWLA W + IN   +KYV LAA+S++KG++D +K+
Sbjct: 419 GKEAKVPEPP-AGHKWKAVQHDNKATWLAMWQENINGH-YKYVMLAANSTVKGKADFKKF 476

Query: 582 EKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTVGC 640
           EKAR LK YI  IRA YTKD  S+ +  +Q A A YLIDK ALRAGNEKD ++EA+TVGC
Sbjct: 477 EKARELKKYIDRIRADYTKDLKSEVMADRQRATAMYLIDKFALRAGNEKDTENEAETVGC 536

Query: 641 CTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGGDDLFDML 699
           C+LK E+VT   PN + F+FLGKDSI++ N   V+  V+  +  F+K  K+ GDD+FD L
Sbjct: 537 CSLKYEHVTLREPNTVIFDFLGKDSIRFYNEFTVDRQVFKNLKMFKKPPKEDGDDIFDRL 596

Query: 700 DTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK-DTKDGDVGEKIVVYQHANKQVAI 758
            T++LN HL   MPGLTAKVFRT+NAS T+  +L +    +  V EK+ +Y   N+QVAI
Sbjct: 597 TTTQLNKHLSSYMPGLTAKVFRTYNASYTMSKLLQELKVTNATVHEKVKLYNDCNRQVAI 656

Query: 759 ICNHQRSVSKSHDTQMTRLNEKLDELQ 785
           +CNH+R+V  SH+ QM +L E++  L+
Sbjct: 657 LCNHKRTVGASHEQQMKKLVEQIKGLR 683



 Score = 71.6 bits (174), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 34/75 (45%), Positives = 50/75 (66%)

Query: 817 SSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK 876
           S E LE  + + + +I+ ++     +E  K VALGTSKINY+DPR+TV +  +  VPIEK
Sbjct: 790 SVEKLEAALEKLDQRIKNLELQSADREGNKEVALGTSKINYIDPRLTVVFSAKFNVPIEK 849

Query: 877 IFNKSLLAKFTWAMD 891
            F+K+L  KF WA++
Sbjct: 850 FFSKTLREKFKWAIE 864


>Q94705_PHYPO (tr|Q94705) DNA topoisomerase I OS=Physarum polycephalum GN=TOP1 PE=2
            SV=2
          Length = 1015

 Score =  389 bits (998), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 238/611 (38%), Positives = 335/611 (54%), Gaps = 66/611 (10%)

Query: 351  DGQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDK 410
            DG K+WT+LVHNGV+F  PY  H VK  Y GKP++L+ + EEVAT YA   +TDY  K+ 
Sbjct: 408  DG-KRWTSLVHNGVVFVEPYVAHGVKFYYDGKPINLSPEAEEVATFYAKYLETDYPKKEN 466

Query: 411  FKENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXX 468
            F  NFW+D+R  L   +  VI++    DFT I+ +                         
Sbjct: 467  FNTNFWSDFRTYLTPEQKKVIKDFSKADFTHIHKYLVEQKELKANRTAEEKKAEKAEKEK 526

Query: 469  XXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIP 528
                  +A+++G ++++ N+ +E PGLF GRG HPK G +K+RI   DI INIGK  P+P
Sbjct: 527  LLQKYGFAMINGHRQRISNWAIERPGLFLGRGAHPKTGLVKKRIEAEDITINIGKGVPVP 586

Query: 529  ECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLK 588
            E P  G +W ++ HD+ V WLA W + IN   FKYV+L ASS++KG+SD +K+E AR LK
Sbjct: 587  EPPP-GHKWCKVVHDDKVAWLAMWKENIN-NGFKYVWLHASSAVKGRSDMKKFEVARKLK 644

Query: 589  DYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 648
            D+I  IR  Y K+  S+++ ++Q A A YLID+LALR GNEKD+D ADTVGCC+L+VE+V
Sbjct: 645  DHIEKIRKKYLKELGSEELEERQRATAIYLIDRLALRVGNEKDEDTADTVGCCSLRVEHV 704

Query: 649  TREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKF-------QKDKKGGDDLFDMLDT 701
            T + P  +  +FLGKDS++Y NTV+V+  V+  + +F       +  KK  +DLFD L T
Sbjct: 705  TLKEPASVTLDFLGKDSMRYHNTVDVDPRVFKNLSEFMYKGGNKKAPKKPENDLFDQLTT 764

Query: 702  SKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKD---GDVGEKIVVYQHA------ 752
            S LN +LK  M  L+AKVFRT+NAS+TL+  L K  +        EK++ Y         
Sbjct: 765  SSLNKYLKGFMENLSAKVFRTYNASLTLEKELAKMPESLIKATADEKVLFYNRCNREVAI 824

Query: 753  --NKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQA---------VLKELRTDLDRARXX 801
              N Q ++   H  ++ K  +       EKL +  A         VL +  +D D  +  
Sbjct: 825  LCNHQRSLSKTHTETMGKIDEKIAEFKKEKLQQQIAYLKGKGKKPVLSDSESDEDTPKKA 884

Query: 802  XXXXXXXXXXXXXNLSS---------------------------EALEKKISQTNAKIEK 834
                         +  +                            AL   + +  A IE+
Sbjct: 885  TPKKATPKKETKSSDEATPNKKRKKDDDEEEADDFKETPKKKVKRALPDSVEKCKAAIER 944

Query: 835  MQRDMK-------TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFT 887
            +   +         K++LK+VAL TSKINY+DPRIT AW KR  + I K+F+KSL  KF 
Sbjct: 945  VDTSINKWNIKKTEKDELKSVALTTSKINYIDPRITAAWAKRVGLDIGKLFSKSLREKFP 1004

Query: 888  WAMDVDPDFRF 898
            WAMDV+ D+ F
Sbjct: 1005 WAMDVEEDWEF 1015


>Q56X27_ARATH (tr|Q56X27) DNA topoisomerase I (Fragment) OS=Arabidopsis thaliana
           GN=At5g55300 PE=2 SV=1
          Length = 270

 Score =  382 bits (982), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 188/267 (70%), Positives = 219/267 (82%)

Query: 632 DDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKG 691
           D+EADTVGCCTLKV NV    PNK+KF+FLGKDSI+Y NTVEVE  VY AI +FQ  K  
Sbjct: 1   DNEADTVGCCTLKVGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSK 60

Query: 692 GDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQH 751
            DDLFD LDTSKLNAHLKEL+PGLTAKVFRT+NASITLD+ML+++TKDGDV +KIVVYQ 
Sbjct: 61  TDDLFDELDTSKLNAHLKELVPGLTAKVFRTYNASITLDEMLSQETKDGDVTQKIVVYQK 120

Query: 752 ANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXX 811
           ANK+VAIICNHQR+VSK+H  Q+ +L  +++EL+ VLKEL+T+LDRA+            
Sbjct: 121 ANKEVAIICNHQRTVSKTHGAQIEKLTARIEELKEVLKELKTNLDRAKKGKPPLEGSDGK 180

Query: 812 XXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHE 871
              +L   A EKKI+Q +AKIEKM+RDM TKEDLKTVALGTSKINYLDPRITVAWCKRHE
Sbjct: 181 KIRSLEPNAWEKKIAQQSAKIEKMERDMHTKEDLKTVALGTSKINYLDPRITVAWCKRHE 240

Query: 872 VPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           VPIEKIF KSLL KF WAMDV+P++RF
Sbjct: 241 VPIEKIFTKSLLEKFAWAMDVEPEYRF 267


>B6KM03_TOXGO (tr|B6KM03) DNA topoisomerase I, putative OS=Toxoplasma gondii ME49
           GN=TGME49_034360 PE=4 SV=1
          Length = 953

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 186/406 (45%), Positives = 254/406 (62%), Gaps = 24/406 (5%)

Query: 353 QKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           +K+W+ L HNG++F PPY+PH  ++ Y GKPV L  + EEVA  +  + ++DY  K +F 
Sbjct: 305 EKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAEEVANYWCGVLESDYATKPRFV 364

Query: 413 ENFWNDWRKLLGKNHVIQ---------------------NLKDCDFTPIYDWCXXXXXXX 451
           ENFW  + + L K+H I                          CDF+PI ++        
Sbjct: 365 ENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVGFAACDFSPIKEYLDKQKELK 424

Query: 452 XXXXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRR 511
                                  +A+VD ++EKVGN RVEPPGLFRGRGEHPK G LKRR
Sbjct: 425 KEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRR 484

Query: 512 IRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSS 571
           I   D+++N+ +DAP+P   +PG  WK++ HDN+VTWLAF+ D IN ++ KY++LAA S 
Sbjct: 485 IFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVTWLAFYRDSINDQV-KYMYLAAQSK 543

Query: 572 LKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD 631
            KGQ D  KYEKAR LK ++  IR  Y K   S +   +Q+  ATYLID LALR G EKD
Sbjct: 544 FKGQQDFLKYEKARKLKLHVDRIRQDYFKKLESTNSLDRQLGTATYLIDVLALRVGGEKD 603

Query: 632 -DDEADTVGCCTLKVENVTREAP-NKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDK 689
            D+EADTVGCC+L+VE++T +    ++ F+FLGKDSI+Y NTV+V   V+  ++ F K K
Sbjct: 604 TDEEADTVGCCSLRVEHLTFDTEKQEVTFDFLGKDSIRYFNTVKVHPQVFKNVVGFCKGK 663

Query: 690 KGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK 735
           K  DD+FD ++++ LN HL++ MPGL+AKVFRT+NASITL + L K
Sbjct: 664 KPEDDVFDKINSAALNNHLRQFMPGLSAKVFRTYNASITLQNELFK 709



 Score =  115 bits (287), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 71/173 (41%), Positives = 94/173 (54%), Gaps = 15/173 (8%)

Query: 741 DVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR-------LNEKLDELQAVLKELRT 793
           +VGE +  Y  AN+ VAI+CNHQRSV K H   M +       L+E + E +  L+ L+ 
Sbjct: 781 NVGELVQFYNDANRAVAILCNHQRSVPKQHAASMQKMEHQQLMLDEDIRECEEYLEFLKK 840

Query: 794 ----DLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRD----MKTKEDL 845
                 +R                 N+     E   ++    + K + D    +K K+D 
Sbjct: 841 PPSKRKERFTFVSDVKDFQGNPRKTNVRDGMKEDVCARRLQALLKRRADHLLKIKLKDDN 900

Query: 846 KTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           KTVALGTSKINY+DPRITVA+CK++EVPIEK+FNKSL  KF WAM     F F
Sbjct: 901 KTVALGTSKINYMDPRITVAFCKKYEVPIEKLFNKSLRLKFPWAMFAKSTFEF 953


>A5BM51_VITVI (tr|A5BM51) Putative uncharacterized protein OS=Vitis vinifera
            GN=VITISV_037391 PE=4 SV=1
          Length = 1449

 Score =  360 bits (924), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 186/272 (68%), Positives = 206/272 (75%), Gaps = 27/272 (9%)

Query: 630  KDDDEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDK 689
            KDDDEADTVGCCTLKVENV  E PN L+F+FLGKDSI+YE TVEVELPVY AI +F+  K
Sbjct: 1202 KDDDEADTVGCCTLKVENVIPEPPNSLQFDFLGKDSIRYEKTVEVELPVYKAIEQFRVGK 1261

Query: 690  KGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVY 749
             G DDLFD LDTSKLNAHLKELMPGLTAKVFRT+NASITLD+M                 
Sbjct: 1262 SGSDDLFDKLDTSKLNAHLKELMPGLTAKVFRTYNASITLDEM----------------- 1304

Query: 750  QHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXX 809
                  VAIICNHQR++SKSH  QMTRL EK+DE++ VL  L+TDL RA+          
Sbjct: 1305 ------VAIICNHQRTISKSHTAQMTRLTEKIDEMKGVLNGLKTDLARAK-KGKPPLKDA 1357

Query: 810  XXXXXNLSSEA---LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAW 866
                 NL+ EA   LE+KI+QTNAKIEKM+RD  TKEDLKTVALGTSKINYLDPRI+VAW
Sbjct: 1358 DGKRRNLTPEATYRLERKIAQTNAKIEKMERDKDTKEDLKTVALGTSKINYLDPRISVAW 1417

Query: 867  CKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
            CKR EVPIEK+FNKSLLAKF WAMDV PDFRF
Sbjct: 1418 CKRQEVPIEKVFNKSLLAKFAWAMDVPPDFRF 1449


>Q4SR65_TETNG (tr|Q4SR65) Chromosome 11 SCAF14528, whole genome shotgun sequence.
           (Fragment) OS=Tetraodon nigroviridis
           GN=GSTENG00014052001 PE=3 SV=1
          Length = 806

 Score =  355 bits (911), Expect = 1e-95,   Method: Compositional matrix adjust.
 Identities = 194/417 (46%), Positives = 252/417 (60%), Gaps = 37/417 (8%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    V+  Y GKP+ L+AD EEVAT +A M D +Y  KD F+
Sbjct: 184 KWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFAKMLDHEYTTKDVFR 243

Query: 413 ENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXX----------- 459
           +NF+ DWRK +   +   I +LK CDF+ ++ +                           
Sbjct: 244 KNFFKDWRKEMTPEEKAKITDLKKCDFSEMHQYFKAQTEARKAMTKEEKLVSPHPHSCRR 303

Query: 460 ------------XXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGK 507
                                      + I+D  KE++ NFR+EPPGLFRGRG+HPKMG 
Sbjct: 304 RLRAAGFIPSAFQKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGM 363

Query: 508 LKRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLA 567
           LKRRIRP DI+IN  KD+  PE P PG RWKE+RHDN VTWL  W + I   + KY+ L 
Sbjct: 364 LKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSI-KYIMLN 421

Query: 568 ASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAG 627
            SS +KG+ D +KYE AR LK  +  IR  Y +D+ SK++  +Q AVA Y IDKLALRAG
Sbjct: 422 PSSRIKGEKDWQKYETARRLKKCVDRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAG 481

Query: 628 NEKDDDE-ADTVGCCTLKVENVTREAPN------KLKFNFLGKDSIKYENTVEVELPVYN 680
           NEK++ E ADTVGCC+L+VE++ +  P        ++F+FLGKDSI+Y N V VE  V+ 
Sbjct: 482 NEKEEGETADTVGCCSLRVEHI-KLYPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFK 540

Query: 681 AILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDT 737
            +  F ++K+  DDLFD L+TS LN HL+ELM GLTAKVFRT+NASITL   L + T
Sbjct: 541 NLQLFMENKEPDDDLFDRLNTSILNKHLQELMDGLTAKVFRTYNASITLQAQLKELT 597



 Score = 81.6 bits (200), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 37/81 (45%), Positives = 58/81 (71%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E+ +K + +   ++ K++     +E+ K +ALGTSK+NYLDPRI+VAWCK+  +PIEKI+
Sbjct: 726 ESKKKAVQRIEDQLMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKWGIPIEKIY 785

Query: 879 NKSLLAKFTWAMDV-DPDFRF 898
           NK+   KF WA+D+ + D+ F
Sbjct: 786 NKTQREKFAWAIDMAEKDYEF 806


>Q1WWG8_DROME (tr|Q1WWG8) IP16129p (Fragment) OS=Drosophila melanogaster GN=Top1
           PE=2 SV=1
          Length = 382

 Score =  333 bits (854), Expect = 4e-89,   Method: Compositional matrix adjust.
 Identities = 176/363 (48%), Positives = 230/363 (63%), Gaps = 10/363 (2%)

Query: 400 MRDTDYMLKDKFKENFWNDWRKLLG--KNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXX 457
           M + DY  K+ F  NF+ D+RK +   +  +I++ + C+F  ++++              
Sbjct: 1   MLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKE 60

Query: 458 XXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDI 517
                            + ++DG KEK+GNFR+EPPGLFRGRGEHPKMG +KRRI+ SD+
Sbjct: 61  EKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDV 120

Query: 518 VINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSD 577
            IN GKD+ +P  P PG RWKE+RHDNTVTWLA W + +  ++ KY+ L  SS LKG+ D
Sbjct: 121 SINCGKDSKVPSPP-PGSRWKEVRHDNTVTWLASWIENVQGQV-KYIMLNPSSKLKGEKD 178

Query: 578 KEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADT 637
             KYE AR L   I  IRA Y  ++ SK++  +Q AVA Y IDKLALRAGNEKD+D+ADT
Sbjct: 179 HIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADT 238

Query: 638 VGCCTLKVENVTRE-----APNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGG 692
           VGCC+L+VE+V          N + F+F GKDSI+Y N VEVE  V+  +  F + KK G
Sbjct: 239 VGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEG 298

Query: 693 DDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQH 751
           DDLFD L+T  LN HLKELM GLTAKVFRT+NAS TL   L+  T     V EK++ Y  
Sbjct: 299 DDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNR 358

Query: 752 ANK 754
           AN+
Sbjct: 359 ANR 361


>A6R590_AJECN (tr|A6R590) Putative uncharacterized protein OS=Ajellomyces
           capsulata (strain NAm1 / WU24) GN=HCAG_04798 PE=3 SV=1
          Length = 651

 Score =  329 bits (843), Expect = 6e-88,   Method: Compositional matrix adjust.
 Identities = 169/370 (45%), Positives = 231/370 (62%), Gaps = 16/370 (4%)

Query: 347 PSSGDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTD 404
           P+ GDG  KWTTL HNGVIFPPPY+P    VKM Y G P+ L  + EEVA  +  M ++ 
Sbjct: 270 PAKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNST 329

Query: 405 YMLKD-KFKENFWNDWRKLL----------GKNHVIQNLKDCDFTPIYDWCXXXXXXXXX 453
           + +++  F++NF+ D+   +          G    +++ + CDF PI+++          
Sbjct: 330 HNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIFEYYEAARLEKKS 389

Query: 454 XXXXXXXXXXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIR 513
                                + + DG K+KVGNFRVEPP LFRGRGEHPK GK+K R+ 
Sbjct: 390 LPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVM 449

Query: 514 PSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLK 573
           P  I INIGK+A +P  P PG +WKEI+HD   TWLA W + +N   +KYV LAA+S +K
Sbjct: 450 PEQITINIGKEAKVP-VPPPGHKWKEIKHDQEGTWLAMWQENVNGN-YKYVMLAANSDIK 507

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDD 633
           G SD +K+EKAR LK +I  IR  Y K    + ++++Q A A YLID+ ALRAGNEK +D
Sbjct: 508 GLSDYKKFEKARELKKHIDRIRKDYKKGLKHELMSERQKATAVYLIDQFALRAGNEKGED 567

Query: 634 EADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQK-DKKGG 692
           EADTVGCC+LK E+VT + PN + F+FLGKDSI++ + VEV+  V+  +  F+K  K+ G
Sbjct: 568 EADTVGCCSLKFEHVTLKPPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIFKKPPKREG 627

Query: 693 DDLFDMLDTS 702
           D++FD L TS
Sbjct: 628 DEIFDRLTTS 637


>Q4N5U3_THEPA (tr|Q4N5U3) DNA topoisomerase I, putative OS=Theileria parva
           GN=TP02_0198 PE=3 SV=1
          Length = 1003

 Score =  325 bits (833), Expect = 1e-86,   Method: Compositional matrix adjust.
 Identities = 171/388 (44%), Positives = 235/388 (60%), Gaps = 9/388 (2%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L HNG+IF P Y PH V +  KG+ + L    EE+ATM+A    T+Y   D + +N
Sbjct: 336 RWKYLEHNGMIFTPEYVPHNVPIKVKGETIHLPPHLEEIATMWAQSIGTNYETSDIYCKN 395

Query: 415 FWNDWRKLLGKNHVIQNLK--DCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXX 472
           FW  +     K+H I+  K  D DF+ I                                
Sbjct: 396 FWQVFVSKFEKDHFIRRCKLTDVDFSLIKTHLEDEKQKKKDNKEFYKAKQQEDAKREYRF 455

Query: 473 XXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECP- 531
             +A+VD V+EKV + ++EPPGLF+GRG HPK G LK R+ P D+++N+ KDAP+P+   
Sbjct: 456 N-YALVDWVREKVSSNKLEPPGLFKGRGLHPKQGLLKARMFPKDVILNLSKDAPVPKVSN 514

Query: 532 --IPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
               G  WK+I HDN+VTWLA++ D IN + FKY++L+A S  KG  D  KY KAR LK 
Sbjct: 515 FQREGHSWKDIYHDNSVTWLAYYKDSINDQ-FKYMYLSAQSKFKGFHDFLKYNKARELKA 573

Query: 590 YIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV- 648
           YI  IR  Y     S DI ++Q+  A YLID LALR G EKD DEADTVGCC+L+VE++ 
Sbjct: 574 YIQKIRDDYNTKMLSMDIYEKQLGTAVYLIDFLALRVGGEKDADEADTVGCCSLRVEHIK 633

Query: 649 -TREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAH 707
            + +  N +  +FLGKDSI+Y NTV +    Y+ + KF   KK  +++F+ ++T+KLN +
Sbjct: 634 FSEKKQNTITLDFLGKDSIRYFNTVTLNDVAYDNLAKFCHRKKASEEIFNKINTNKLNEY 693

Query: 708 LKELMPGLTAKVFRTFNASITLDDMLNK 735
           L+ELM GL+AKVFRT+NASITL +   +
Sbjct: 694 LRELMDGLSAKVFRTYNASITLQNQFKR 721



 Score =  134 bits (336), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 77/179 (43%), Positives = 105/179 (58%), Gaps = 20/179 (11%)

Query: 740  GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLN-------EKLDELQAVLKELR 792
            G+V E +  Y +AN++VAI+CNHQRS+ K H+T MT+L        E + EL    K L+
Sbjct: 825  GNVSELLQFYNYANREVAILCNHQRSIPKQHETSMTKLKLQAKMLKEDIQELNEYCKHLQ 884

Query: 793  TDLD-----RARXXXXXXXXXXXXXXXNLSSEALEKKISQTN----AKIEKMQRD----M 839
            ++        ++                +  EA + K+S  N    A ++K Q+D    M
Sbjct: 885  SNSKGEFKFESKTKDVNGNPRKLITKPGMKLEAAKNKLSTLNYLCFAPLKKKQKDHAIKM 944

Query: 840  KTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
              K+  KTVALGTSKINY+DPRITVA+CK++E+PIEK+FNKSL  KF WAM V  DF F
Sbjct: 945  TIKDSNKTVALGTSKINYMDPRITVAFCKKYEIPIEKVFNKSLRMKFPWAMYVRSDFTF 1003


>Q8RXI5_ARATH (tr|Q8RXI5) Putative DNA topoisomerase I (Fragment) OS=Arabidopsis
           thaliana GN=At5g55310 PE=2 SV=2
          Length = 232

 Score =  325 bits (832), Expect = 1e-86,   Method: Compositional matrix adjust.
 Identities = 160/226 (70%), Positives = 182/226 (80%)

Query: 673 EVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDM 732
           EVE  VY AI +FQ  K   DDLFD LDTSKLN HLKELM GLTAKVFRT+NASITLD M
Sbjct: 1   EVEPLVYKAIGQFQAGKSKTDDLFDELDTSKLNTHLKELMAGLTAKVFRTYNASITLDLM 60

Query: 733 LNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELR 792
           L+K+T+DGDV EK+VVYQ ANK+VAIICNHQR+VSKSH  Q+ +L  K++EL+  +KEL 
Sbjct: 61  LSKETRDGDVPEKVVVYQQANKEVAIICNHQRTVSKSHGAQVEKLAVKIEELREQIKELN 120

Query: 793 TDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGT 852
            DLDRA+               NL+ EALEKKI QT  KIEKM+RDM+TKED+KTVALGT
Sbjct: 121 IDLDRAKKGRTPLMGSDGKRKRNLTPEALEKKIMQTQGKIEKMERDMQTKEDMKTVALGT 180

Query: 853 SKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           SKINY+DPRITVAWCKRH+VPIEKIFNKSLLAKF WAMDVDP+FRF
Sbjct: 181 SKINYMDPRITVAWCKRHDVPIEKIFNKSLLAKFAWAMDVDPEFRF 226


>Q8I3Z9_PLAF7 (tr|Q8I3Z9) Topoisomerase I OS=Plasmodium falciparum (isolate 3D7)
           GN=PFE0520c PE=3 SV=1
          Length = 839

 Score =  314 bits (804), Expect = 2e-83,   Method: Compositional matrix adjust.
 Identities = 176/431 (40%), Positives = 235/431 (54%), Gaps = 51/431 (11%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H V + YK   ++L A  EE+AT +     +DY  K+KF  N
Sbjct: 155 QWNYLEHRGLIFSPPYVQHHVPIFYKSIKIELNAKSEELATYWCSAIGSDYCTKEKFILN 214

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L  +++I+             N K  DF PI D                   
Sbjct: 215 FFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMPIKDHLLKLREEKLNKTKEEKEE 274

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 275 EKKMRMEKELPYTYALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 334

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP+P     + G  W +I HDN VTWLA++ D IN ++ KY FL+A S  KG  D  
Sbjct: 335 SKDAPVPRLYDNMCGHNWGDIYHDNKVTWLAYYKDSINDQI-KYTFLSAQSKFKGYKDLM 393

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTV 638
           KYE AR LK  +  IR  Y     +K+I  +Q+  A YLID LALR G EKD D+EADTV
Sbjct: 394 KYENARKLKSCVHKIREDYKNKMKNKNIIDKQLGTAVYLIDFLALRVGGEKDIDEEADTV 453

Query: 639 GCCTLKVENVT------------------REAPNKL----------------KFNFLGKD 664
           GCC+L+VE+++                   E  NK+                  +FLGKD
Sbjct: 454 GCCSLRVEHISFAHDIPFKSVDSKEQKTNDEKVNKIPLPTNLESISSEDCYITLDFLGKD 513

Query: 665 SIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFN 724
           SI+Y NTV+++   Y  I+ F K+K   + +FD +  SKLN +LKE+MP L+AKVFRT+N
Sbjct: 514 SIRYFNTVKIDKQAYINIIIFCKNKNRDEGVFDQITCSKLNEYLKEIMPTLSAKVFRTYN 573

Query: 725 ASITLDDMLNK 735
           ASITLD  L +
Sbjct: 574 ASITLDQQLKR 584



 Score =  132 bits (332), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 70/171 (40%), Positives = 104/171 (60%), Gaps = 12/171 (7%)

Query: 740 GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL-------NEKLDELQAVLKELR 792
            ++ E I  Y +AN++VAI+CNHQRS+ K HDT M+++       NE + E +  L+ L+
Sbjct: 669 SNINELINFYNNANREVAILCNHQRSIPKQHDTTMSKIKKQIELYNEDIKEYKKYLQHLK 728

Query: 793 TDLDR-----ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKT 847
            + D+     ++               N+  E+ +KK+     K+E +   MK ++D KT
Sbjct: 729 KNSDKKFIFVSKVSTLDGTLRPNKVKENMKEESCKKKLITLIKKVELLNNQMKVRDDNKT 788

Query: 848 VALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           +ALGTSKINY+DPRITVA+CK+ E+PIEK+FN+SL  KF WAM    +F F
Sbjct: 789 IALGTSKINYMDPRITVAFCKKFEIPIEKVFNRSLRLKFPWAMFATKNFTF 839


>Q26024_PLAFA (tr|Q26024) Topoisomerase I OS=Plasmodium falciparum PE=3 SV=1
          Length = 839

 Score =  314 bits (804), Expect = 2e-83,   Method: Compositional matrix adjust.
 Identities = 176/431 (40%), Positives = 235/431 (54%), Gaps = 51/431 (11%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H V + YK   ++L A  EE+AT +     +DY  K+KF  N
Sbjct: 155 QWNYLEHRGLIFSPPYVQHHVPIFYKSIKIELNAKSEELATYWCSAIGSDYCTKEKFILN 214

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L  +++I+             N K  DF PI D                   
Sbjct: 215 FFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMPIKDHLLKLREEKLNKTKEEKEE 274

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 275 EKKMRMEKELPYTYALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 334

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP+P     + G  W +I HDN VTWLA++ D IN ++ KY FL+A S  KG  D  
Sbjct: 335 SKDAPVPRLYDNMCGHNWGDIYHDNKVTWLAYYKDSINDQI-KYTFLSAQSKFKGYKDLM 393

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTV 638
           KYE AR LK  +  IR  Y     +K+I  +Q+  A YLID LALR G EKD D+EADTV
Sbjct: 394 KYENARKLKSCVHKIREDYKNKMKNKNIIDKQLGTAVYLIDFLALRVGGEKDIDEEADTV 453

Query: 639 GCCTLKVENVT------------------REAPNKL----------------KFNFLGKD 664
           GCC+L+VE+++                   E  NK+                  +FLGKD
Sbjct: 454 GCCSLRVEHISFAHDIPFKSVDSKEQKTNDEKVNKIPLPTNLESISSEDCYITLDFLGKD 513

Query: 665 SIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFN 724
           SI+Y NTV+++   Y  I+ F K+K   + +FD +  SKLN +LKE+MP L+AKVFRT+N
Sbjct: 514 SIRYFNTVKIDKQAYINIIIFCKNKNRDEGVFDQITCSKLNEYLKEIMPTLSAKVFRTYN 573

Query: 725 ASITLDDMLNK 735
           ASITLD  L +
Sbjct: 574 ASITLDQQLKR 584



 Score =  132 bits (332), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 70/171 (40%), Positives = 104/171 (60%), Gaps = 12/171 (7%)

Query: 740 GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL-------NEKLDELQAVLKELR 792
            ++ E I  Y +AN++VAI+CNHQRS+ K HDT M+++       NE + E +  L+ L+
Sbjct: 669 SNINELINFYNNANREVAILCNHQRSIPKQHDTTMSKIKKQIELYNEDIKEYKKYLQHLK 728

Query: 793 TDLDR-----ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKT 847
            + D+     ++               N+  E+ +KK+     K+E +   MK ++D KT
Sbjct: 729 KNSDKKFIFVSKVSTLDGTLRPNKVKENMKEESCKKKLITLIKKVELLNNQMKVRDDNKT 788

Query: 848 VALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           +ALGTSKINY+DPRITVA+CK+ E+PIEK+FN+SL  KF WAM    +F F
Sbjct: 789 IALGTSKINYMDPRITVAFCKKFEIPIEKVFNRSLRLKFPWAMFATKNFTF 839


>Q4UDP8_THEAN (tr|Q4UDP8) DNA topoisomerase i, putative OS=Theileria annulata
           GN=TA11835 PE=3 SV=1
          Length = 999

 Score =  312 bits (800), Expect = 7e-83,   Method: Compositional matrix adjust.
 Identities = 167/396 (42%), Positives = 235/396 (59%), Gaps = 19/396 (4%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L HNG+IF P Y PH + ++ KG+ + L  + EE+ATM+A    T+Y   + + +N
Sbjct: 337 RWKYLEHNGMIFTPEYVPHNIPIMVKGETIHLPPNLEEIATMWAQSMGTNYETSEIYCKN 396

Query: 415 FWNDWRKLLGKNHVIQN--LKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXX 472
           FW  +     K+H I+   L D DF+ I +                              
Sbjct: 397 FWQVFVSKFEKDHFIRRCKLSDADFSLIKNHLEEEKQKKKDNKEFYKAKQQEDAKREYRF 456

Query: 473 XXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECP- 531
             +A+VD V+EKV + ++EPPGLF+GRG HPK G LK R+ P D+++N+ KDAP+P+   
Sbjct: 457 N-YALVDWVREKVSSNKLEPPGLFKGRGLHPKQGLLKSRMFPKDVILNLSKDAPVPKVTN 515

Query: 532 --IPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKD 589
               G  WK+I HDN+VTWLA++ D IN + FKY++L+A S  KG  D  KY KAR LK 
Sbjct: 516 FQREGHSWKDIYHDNSVTWLAYYKDSINDQ-FKYMYLSAQSKFKGFHDFLKYNKARELKA 574

Query: 590 YIGNIRAAYTKDF--------TSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCC 641
           YI  IR  Y             + DI ++Q+  A YLID LALR G EKD DEADTVGCC
Sbjct: 575 YIQKIRDDYNTKMLCMTIIYTITLDIYEKQLGTAVYLIDYLALRVGGEKDADEADTVGCC 634

Query: 642 TLKVENV--TREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDML 699
           +L+VE++  + +  N +  +FLGKDSI+Y NT+      Y+ + KF   KK  + +F  +
Sbjct: 635 SLRVEHIKFSEKKKNTITLDFLGKDSIRYFNTLND--VAYDNLAKFCNRKKSSEGIFSKI 692

Query: 700 DTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK 735
           +T+KLN +L+ELM GL+AKVFRT+NASITL +   +
Sbjct: 693 NTNKLNEYLRELMDGLSAKVFRTYNASITLQNQFKR 728



 Score =  131 bits (330), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 75/175 (42%), Positives = 103/175 (58%), Gaps = 20/175 (11%)

Query: 740 GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLN-------EKLDELQAVLKELR 792
           G+V E +  Y +AN++VAI+CNHQRS+ K H+T MT+L        E + EL    K L+
Sbjct: 829 GNVSELLQFYNYANREVAILCNHQRSIPKQHETSMTKLKLQAKMLKEDIQELNEYCKHLQ 888

Query: 793 TDLD-----RARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRD----MKTKE 843
           ++        ++                +  EA + K+    A ++K Q+D    M  K+
Sbjct: 889 SNSKDEFKFESKTKDVNGNPRKLITKPGMKLEAAKNKL----ATLKKKQKDHNIKMTIKD 944

Query: 844 DLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
             KTVALGTSKINY+DPRITVA+CK++E+PIEK+FNKSL  KF WAM V  DF F
Sbjct: 945 SNKTVALGTSKINYMDPRITVAFCKKYEIPIEKVFNKSLRMKFPWAMCVRSDFTF 999


>B4E061_HUMAN (tr|B4E061) cDNA FLJ51170, highly similar to DNA topoisomerase I,
           mitochondrial (EC 5.99.1.2) OS=Homo sapiens PE=2 SV=1
          Length = 477

 Score =  308 bits (789), Expect = 1e-81,   Method: Compositional matrix adjust.
 Identities = 171/373 (45%), Positives = 230/373 (61%), Gaps = 19/373 (5%)

Query: 505 MGKLKRRIRPSDIVINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYV 564
           MG LKRRI P D+VIN  +D+ IPE P  G +WKE+R DNTVTWLA W + I   + KY+
Sbjct: 1   MGMLKRRITPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESIQNSI-KYI 58

Query: 565 FLAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLAL 624
            L   S LKG++  +K+E AR L+ ++  IR+ Y  D+ S+++  +Q AVA Y IDKLAL
Sbjct: 59  MLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLAL 118

Query: 625 RAGNEKDDDEA-DTVGCCTLKVENVTRE-----APNKLKFNFLGKDSIKYENTVEVELPV 678
           RAGNEK+D EA DTVGCC+L+VE+V          + ++F+FLGKD I+Y N V VE PV
Sbjct: 119 RAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPV 178

Query: 679 YNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK 738
           Y  +  F ++K   DDLFD L T+ LN HL+ELM GLTAKVFRT+NASITL + L   T+
Sbjct: 179 YKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTR 238

Query: 739 DGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDR 797
             D +  KI+ Y  AN+ VAI+CNHQR+   + +  M  L  K       ++  +  +  
Sbjct: 239 AEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTK-------IQAKKEQVAE 291

Query: 798 ARXXXXXXXXXXXXXXXNLSSEALEKK---ISQTNAKIEKMQRDMKTKEDLKTVALGTSK 854
           AR                 S   LEKK   + +   ++ ++      KE+ K VALGTSK
Sbjct: 292 ARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSK 351

Query: 855 INYLDPRITVAWC 867
           +NYLDPRI++AWC
Sbjct: 352 LNYLDPRISIAWC 364


>Q7RE42_PLAYO (tr|Q7RE42) Eukaryotic DNA topoisomerase I, DNA binding, putative
           OS=Plasmodium yoelii yoelii GN=PY05226 PE=3 SV=1
          Length = 886

 Score =  308 bits (789), Expect = 1e-81,   Method: Compositional matrix adjust.
 Identities = 173/427 (40%), Positives = 231/427 (54%), Gaps = 49/427 (11%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H + + YK   ++L    EE+AT +  +  TDY  KDKF  N
Sbjct: 207 QWNYLEHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELATYWCSVIGTDYCTKDKFILN 266

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L K+++I+             N K  DF  I +                   
Sbjct: 267 FFKTFINNLEKDNIIRRENENKIKNGDISNFKFIDFMTIKEHLIKLREERLNKTKEEKEE 326

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 327 EKKIRMEKELPYTFALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 386

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP P     + G  W +I HDN VTWLA++ D IN ++ KY FL+A S  KG  D  
Sbjct: 387 SKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYKDSINDQI-KYTFLSAQSKFKGYKDFL 445

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTV 638
           KYE AR LK  +  IR  Y     +K+I  +Q+  A YLID LALR G EKD D+EADTV
Sbjct: 446 KYENARKLKSCVHKIRKDYQNKMKNKNIVNKQLGTAVYLIDFLALRVGGEKDIDEEADTV 505

Query: 639 GCCTLKVENVT--------------------------------REAPNKLKFNFLGKDSI 666
           GCC+L+VE+V+                                 E    +  +FLGKDSI
Sbjct: 506 GCCSLRVEHVSFSHNVIIKNENTNDENDNKISKIPLPKNLEDILEDDCYITLDFLGKDSI 565

Query: 667 KYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNAS 726
           +Y NTV+++   Y  ++ F K+K   + +FD +  SKLN +LKE+MP L+AKVFRT+NAS
Sbjct: 566 RYFNTVKIDKQAYINMIIFCKNKNKDEGVFDQITCSKLNEYLKEIMPTLSAKVFRTYNAS 625

Query: 727 ITLDDML 733
           ITLD  L
Sbjct: 626 ITLDQQL 632



 Score =  132 bits (331), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 71/172 (41%), Positives = 106/172 (61%), Gaps = 13/172 (7%)

Query: 740 GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL-------NEKLDELQAVLKELR 792
            +V + I  + +AN++VAI+CNHQRS+ K HDT M+++       NE + E +  L+ L+
Sbjct: 715 SNVNDLINFFNNANREVAILCNHQRSIPKQHDTTMSKIKKQIEIYNEDMQEYKKYLQYLK 774

Query: 793 TDLDR------ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLK 846
            + +       ++               N+  E+ +KK+     K+E ++  MK ++D K
Sbjct: 775 KNNNEKEFTFVSKVVTLDGSLRPNKVKENMKEESCKKKLIALIKKVELLENQMKVRDDNK 834

Query: 847 TVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           T+ALGTSKINY+DPRITVA+CK+ E+PIEKIFN+SL  KF WAM V  +FRF
Sbjct: 835 TIALGTSKINYMDPRITVAFCKQFEIPIEKIFNRSLRLKFPWAMFVTKNFRF 886


>Q4YYG2_PLABE (tr|Q4YYG2) Topoisomerase I, putative (Fragment) OS=Plasmodium
           berghei GN=PB001130.01.0 PE=3 SV=1
          Length = 805

 Score =  306 bits (784), Expect = 4e-81,   Method: Compositional matrix adjust.
 Identities = 173/427 (40%), Positives = 231/427 (54%), Gaps = 49/427 (11%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H + + YK   ++L    EE+AT +  +  TDY  K+KF  N
Sbjct: 152 QWNYLEHRGIIFSPPYVQHNIPIFYKSVKIELNPKAEELATYWCSVIGTDYCTKEKFILN 211

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L K+++I+             N K  DF  I +                   
Sbjct: 212 FFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDFMTIKENLIKLREERLNKTKEEKEE 271

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 272 EKKIRMEKELPYTFALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 331

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP P     + G  W +I HDN VTWLA++ D IN ++ KY FL+A S  KG  D  
Sbjct: 332 SKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYKDSINDQI-KYTFLSAQSKFKGYKDFL 390

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTV 638
           KYE AR LK  +  IR  Y     SK+I  +Q+  A YLID LALR G EKD D+EADTV
Sbjct: 391 KYENARKLKSCVHKIRKDYQNKMKSKNIINKQLGTAVYLIDFLALRVGGEKDIDEEADTV 450

Query: 639 GCCTLKVENVT--------------------------------REAPNKLKFNFLGKDSI 666
           GCC+L+VE+V+                                 E    +  +FLGKDSI
Sbjct: 451 GCCSLRVEHVSFSHNVIIKNENTNDENDNKISKIPLPKNLEDILEDDCYVTLDFLGKDSI 510

Query: 667 KYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNAS 726
           +Y NTV+++   Y  ++ F K+K   + +FD +  SKLN +LKE+MP L+AKVFRT+NAS
Sbjct: 511 RYFNTVKIDKQAYINMIIFCKNKNKDEGVFDQITCSKLNEYLKEIMPTLSAKVFRTYNAS 570

Query: 727 ITLDDML 733
           ITLD  L
Sbjct: 571 ITLDQQL 577



 Score = 94.7 bits (234), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 53/146 (36%), Positives = 86/146 (58%), Gaps = 13/146 (8%)

Query: 740 GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL-------NEKLDELQAVLKELR 792
            +V + I  + +AN++VAI+CNHQRS+ K HDT M+++       NE + E +  L+ L+
Sbjct: 660 SNVNDLINFFNNANREVAILCNHQRSIPKQHDTTMSKIKKQIEIYNEDMQEYKKYLQYLK 719

Query: 793 TDLDR------ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLK 846
            + +       ++               N+  E+ +KK+     K+E ++  MK ++D K
Sbjct: 720 KNNNEKEFTFVSKVVTLDGSLRPNKVKENMKEESCKKKLIALIKKVELLENQMKVRDDNK 779

Query: 847 TVALGTSKINYLDPRITVAWCKRHEV 872
           T+ALGTSKINY+DPRITVA+CK+ E+
Sbjct: 780 TIALGTSKINYMDPRITVAFCKQFEI 805


>Q0V9D3_XENTR (tr|Q0V9D3) Putative uncharacterized protein (Fragment) OS=Xenopus
           tropicalis PE=2 SV=1
          Length = 495

 Score =  290 bits (741), Expect = 5e-76,   Method: Compositional matrix adjust.
 Identities = 151/327 (46%), Positives = 204/327 (62%), Gaps = 14/327 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GKP+ L+   EEVA+ +A M D +Y  K+ F+
Sbjct: 132 KWKFLEHEGPVFAPPYEPLPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFR 191

Query: 413 ENFWNDWRK--LLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            N++ DWRK   L +  VI +L  CDFT ++ +                           
Sbjct: 192 NNYFMDWRKEMTLEERMVITDLAKCDFTEMFTYYKGKMEEKKNKSKEDKLKIKEENEKLL 251

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               +  +D  +E++GNF++EPP LFRGRG+HPK G LK+RI P DI+IN  KD+ IPE 
Sbjct: 252 QEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKIPE- 310

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDNTVTWLA W + +   + KY+ L A+S LKG+ D EKYE AR LK +
Sbjct: 311 PPPGHKWKEVRHDNTVTWLASWTENVQGSV-KYIMLNANSKLKGEKDWEKYEVARKLKHH 369

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVT 649
           +  IR  Y ++F SK++  +Q AVA Y IDKLALRAGNEK++ E ADTVGCC+L+VE++ 
Sbjct: 370 VVTIRKTYRENFKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHI- 428

Query: 650 REAPN------KLKFNFLGKDSIKYEN 670
           +  P        ++F+FLGKDSI+Y N
Sbjct: 429 KLYPELDGDKYVVEFDFLGKDSIRYYN 455


>A8PY85_MALGO (tr|A8PY85) Putative uncharacterized protein OS=Malassezia globosa
           (strain ATCC 96807 / CBS 7966) GN=MGL_1612 PE=3 SV=1
          Length = 877

 Score =  288 bits (737), Expect = 1e-75,   Method: Compositional matrix adjust.
 Identities = 184/484 (38%), Positives = 251/484 (51%), Gaps = 46/484 (9%)

Query: 350 GDGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYML 407
           G G+++WTTL+H G  FP PY P    V + Y G PV L  + EEVA  YAV  ++ +  
Sbjct: 116 GGGEQRWTTLIHKGPKFPEPYTPLPKDVMLKYDGHPVPLPPESEEVAMFYAVKLESQHAS 175

Query: 408 KDKFKENFWNDWRKLLGK-----NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXX 462
              F  NF+ D+   L +        IQ  +  DF  +Y++                   
Sbjct: 176 NPIFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSM 235

Query: 463 XXXXXXXXXX----XXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIV 518
                             +VDG+++K GN  VEPPGLF GRG HPK G++K RI+P  I 
Sbjct: 236 RKAELAARRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGAHPKAGRVKTRIQPEQIT 295

Query: 519 INIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDK 578
           IN   D P P+ P  G  W E+     VTWLA W + IN   FKYVFL ASS+ K +SD+
Sbjct: 296 INHSADHPPPKPPK-GHSWGEVVERKDVTWLALWRENINGG-FKYVFLDASSTFKTESDR 353

Query: 579 EKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTV 638
           EK+EKAR L   +  +RA   K+  SKD   Q IA   +LID  +LRAGNEK +DEA+T 
Sbjct: 354 EKFEKARRLDTCVKQVRADVLKNLRSKDRLDQMIATIVWLIDNFSLRAGNEKGEDEAETY 413

Query: 639 GCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELP-VYNAILKFQK----DKKGGD 693
           G C+L+  + T   PN+L  +FLGKDS+K+E T+ +  P VY  I  F K     KKG D
Sbjct: 414 GVCSLRCGHATLIPPNQLNLSFLGKDSMKFEETLTITNPHVYKNITSFLKSDGHQKKGPD 473

Query: 694 D-LFDM----------LDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNK------- 735
           D +F            L    +N  L   M GL+AKVFRT+NAS T   +L++       
Sbjct: 474 DPIFAAPKARGDKMTPLPPDVVNQFLGRYMKGLSAKVFRTYNASATFQGLLDETEEWLAS 533

Query: 736 ----DTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKEL 791
                 ++       + Y  AN+QVAI+CNHQ++V  +H T    LN+ LD  +  +  +
Sbjct: 534 RPTPQEREITPANLRIAYNEANRQVAILCNHQKTV--NHVT----LNKSLDRTKDKIFAI 587

Query: 792 RTDL 795
           + D+
Sbjct: 588 KYDI 591


>A9A2H9_NITMS (tr|A9A2H9) 2-alkenal reductase OS=Nitrosopumilus maritimus (strain
           SCM1) GN=Nmar_1322 PE=4 SV=1
          Length = 551

 Score =  285 bits (730), Expect = 9e-75,   Method: Compositional matrix adjust.
 Identities = 183/548 (33%), Positives = 286/548 (52%), Gaps = 22/548 (4%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           KW TL H G++FPP Y+   +K+  KG+ VDL  DQEE+   +A  +DT Y     F++N
Sbjct: 2   KWKTLQHKGILFPPAYEAQGIKIKIKGEKVDLNLDQEEMIYQWAKKKDTPYAQDKVFQKN 61

Query: 415 FWNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXX----XXXXXXXXXXXXXXXXXXXXXXX 470
           F  D+ K L       + +D DF+  Y                                 
Sbjct: 62  FTADFAKTLDSKFKKISYEDIDFSDAYKLVDKEKDLKEMMTKEEKKAIAAKRKELREELK 121

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
                A++DG + +VGN+  EPPG+F GRGEHP  G+ K R+   D+ +N+GK+A +PE 
Sbjct: 122 SKYGVAVMDGKEVEVGNYMAEPPGIFIGRGEHPLRGRWKPRVTAKDVTLNLGKEAKVPEG 181

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
                +W +I HD    WLA W D +  K  KYV+L+ SS LK   DKEKYEKA  L+  
Sbjct: 182 -----KWGKIIHDKDSMWLASWMDFLTQKR-KYVWLSDSSDLKQGRDKEKYEKAVKLEKE 235

Query: 591 IGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTR 650
           I  I+ A  KD   KD  K  +A A YLI K A+R G+EKD+DEADTVG  TL+ E++ +
Sbjct: 236 IEKIKKAMVKDM--KDSKKNNVATACYLIYKTAMRVGDEKDEDEADTVGATTLRKEHI-K 292

Query: 651 EAPNKLKFNFLGKDSIKYENTVEV---ELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAH 707
              + ++F+FLGKDS++++ T++V   +      + K  + KK  +++F  + +  +N +
Sbjct: 293 ITSDTIEFDFLGKDSVRWQETLKVVGDDKQFQENLKKLIEKKKPSEEIFHDITSRDVNKY 352

Query: 708 LKELMPGLTAKVFRTFNASITLDDML-NKDTKDGDV-GEKIVVYQHANKQVAIICNHQRS 765
           L  ++ G+TAKVFRT+ A+  + + L N D   G    EK+   + AN + AI+CNH+R+
Sbjct: 353 LSGIVKGVTAKVFRTYQATTVVKNYLVNHDNIKGKSDNEKLYHAKLANLEAAIMCNHKRT 412

Query: 766 VSKSHDTQMTRLNEKLD--ELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSS--EAL 821
           + K+ +  + +  + L   E +   ++ +  L +                  + +  E +
Sbjct: 413 IPKTFEQSLQKKKDTLKKREREKAWEKTQQTLKKVESSEPKTDTQKKNKEKRIKTLNEQI 472

Query: 822 EKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKS 881
           +K+  +   +IEK++  +   E  +   LGTS  NY+DPR+  AW        EK++  +
Sbjct: 473 KKQKQKHKERIEKLKLQVDLSEKTRDYNLGTSLRNYIDPRVFKAWTDEVGAEWEKLYTSA 532

Query: 882 LLAKFTWA 889
           L  KF W 
Sbjct: 533 LQKKFLWV 540


>B3TAG0_9CREN (tr|B3TAG0) Putative eukaryotic DNA topoisomerase I, catalytic core
           OS=uncultured marine crenarchaeote HF4000_APKG8D22
           GN=ALOHA_HF4000APKG8D22ctg20g3 PE=4 SV=1
          Length = 563

 Score =  270 bits (689), Expect = 5e-70,   Method: Compositional matrix adjust.
 Identities = 176/557 (31%), Positives = 286/557 (51%), Gaps = 31/557 (5%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRD------TDYMLK 408
           KW TL HNG++FPP ++   +K+  K + V L   QEE+   ++  +D      T+  ++
Sbjct: 2   KWKTLQHNGILFPPDFESKGIKIKIKRENVALNLLQEEMIYQWSKKKDAPKPGATEKYIE 61

Query: 409 DK-FKENFWNDWRKLLGKNHVIQNLK--DCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXX 465
           D  F++NF +D+ K    N   +NL+  D DF+  Y                        
Sbjct: 62  DSIFQKNFVSDFAKTF--NGKFKNLQYSDIDFSLAYQLVDKEKEEKELLTKEDKKALAIK 119

Query: 466 XXXXXXXXXW----AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                          I+DG + ++GN+  EPPG+F GRGEHP  G+ K R+   D+ +N+
Sbjct: 120 RKEIREEMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLNL 179

Query: 522 GKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKY 581
           GK+A IPE      +W +I HD    W+A W D +  K  KYV+LA ++ +K + D+ KY
Sbjct: 180 GKEAKIPEA-----KWGKIVHDRNSMWIASWMDILTQKR-KYVWLADTAGIKQEMDQAKY 233

Query: 582 EKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCC 641
           +KA+ L   I N++A   KD  S +   ++IA A YLI + ++R G+EKD DEADTVG  
Sbjct: 234 DKAKNLSKEIENVKAQIIKDMQSNEQKNKRIATACYLIYRTSMRVGDEKDPDEADTVGAT 293

Query: 642 TLKVENVTREAPNKLKFNFLGKDSIKYENTVEVE---LPVYNAILKFQKDKKGGDDLFDM 698
           TL+ E++ + + N ++F+FLGKD +++  T+  E      Y+ + +F  +KK   ++FD 
Sbjct: 294 TLRKEHI-KLSENAIEFDFLGKDGVRWRETIPAEGHDKQFYDNLKEFIANKKESQEIFDG 352

Query: 699 LDTSKLNAHLKELMPGLTAKVFRTFNASITLDDML--NKDTKDGDVGEKIVVYQHANKQV 756
           + +  +NA+   ++ GL+AKVFRT+ AS  +   L  + D K     +K+   + AN   
Sbjct: 353 IASRHVNAYYSTIVKGLSAKVFRTYLASSVVSKNLRAHDDIKSKSDMKKLFHAKSANLDA 412

Query: 757 AIICNHQRSVSKSHDTQMTRLNEKLDELQAV--LKELRTDLDRARXXXXXXXXXXXXXXX 814
           AI+CNH+R++ K+ +  + +  + L+ ++     K+    L +A+               
Sbjct: 413 AIMCNHKRTIPKNFEASLQKKKDTLENVEKTKPWKKSAVLLKKAQSKITKTEKQKEMQNE 472

Query: 815 NLSSEALEKKISQTN--AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEV 872
            +       K  +T    +IEK++  +   E  +   LGTS  NY+DPRI  AW     V
Sbjct: 473 RIKKIKTMIKKRKTKHAERIEKLELQINLTEKTRDYNLGTSLRNYIDPRIFKAWTDEVGV 532

Query: 873 PIEKIFNKSLLAKFTWA 889
             EK++   L  KF W 
Sbjct: 533 EWEKLYTSVLQKKFLWV 549


>B3T4E9_9CREN (tr|B3T4E9) Putative eukaryotic DNA topoisomerase I, catalytic core
           OS=uncultured marine crenarchaeote HF4000_ANIW133O4
           GN=ALOHA_HF4000ANIW133O4ctg2g37 PE=4 SV=1
          Length = 563

 Score =  267 bits (682), Expect = 3e-69,   Method: Compositional matrix adjust.
 Identities = 175/557 (31%), Positives = 286/557 (51%), Gaps = 31/557 (5%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRD------TDYMLK 408
           KW TL HNG++FPP ++   +K+  K + V L   QEE+   ++  +D      T+  ++
Sbjct: 2   KWKTLQHNGILFPPDFESKGIKIKIKRENVALNLLQEEMIYQWSKKKDAPKPGATEKYIE 61

Query: 409 DK-FKENFWNDWRKLLGKNHVIQNLK--DCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXX 465
           D  F++NF +D+ K    N   +NL+  D DF+  +                        
Sbjct: 62  DPIFQKNFVSDFAKTF--NGKFKNLQYSDIDFSLAHQLVDKEKEEKELLTKEDKKALAIK 119

Query: 466 XXXXXXXXXW----AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                          I+DG + ++GN+  EPPG+F GRGEHP  G+ K R+   D+ +N+
Sbjct: 120 RKEIREEMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLNL 179

Query: 522 GKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKY 581
           GK+A IPE      +W +I HD    W+A W D +  K  KYV+LA ++ +K + D+ KY
Sbjct: 180 GKEAKIPEA-----KWGKIVHDRNSMWIASWMDILTQKR-KYVWLADTAGIKQEMDQAKY 233

Query: 582 EKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCC 641
           +KA+ L   I N++A   KD  S +   ++IA A YLI + ++R G+EKD DEADTVG  
Sbjct: 234 DKAKNLSKEIENVKAQIIKDMQSNEQKNKRIATACYLIYRTSMRVGDEKDPDEADTVGAT 293

Query: 642 TLKVENVTREAPNKLKFNFLGKDSIKYENTVEVE---LPVYNAILKFQKDKKGGDDLFDM 698
           TL+ E++ + + N ++F+FLGKD +++  T+  E      Y+ + +F  +KK   ++FD 
Sbjct: 294 TLRKEHI-KLSENAIEFDFLGKDGVRWRETIPAEGHDKQFYDNLKEFIANKKESQEIFDG 352

Query: 699 LDTSKLNAHLKELMPGLTAKVFRTFNASITLDDML--NKDTKDGDVGEKIVVYQHANKQV 756
           + +  +NA+   ++ GL+AKVFRT+ AS  +   L  + D K     +K+   + AN   
Sbjct: 353 IASRHVNAYYSTIVKGLSAKVFRTYLASSVVSKNLRAHDDIKSKSDMKKLFHAKSANLDA 412

Query: 757 AIICNHQRSVSKSHDTQMTRLNEKLDELQAV--LKELRTDLDRARXXXXXXXXXXXXXXX 814
           AI+CNH+R++ K+ +  + +  + L+ ++     K+    L +A+               
Sbjct: 413 AIMCNHKRTIPKNFEASLQKKKDTLENVEKTKPWKKSEVLLKKAQSKITKTEKQKEMQNE 472

Query: 815 NLSSEALEKKISQTN--AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEV 872
            +       K  +T    +IEK++  +   E  +   LGTS  NY+DPRI  AW     V
Sbjct: 473 RIKKIKTMIKKRKTKHAERIEKLELQINLTEKTRDYNLGTSLRNYIDPRIFKAWTDEVGV 532

Query: 873 PIEKIFNKSLLAKFTWA 889
             EK++   L  KF W 
Sbjct: 533 EWEKLYTSVLQKKFLWV 549


>A0RU10_CENSY (tr|A0RU10) DNA topoisomerase IB OS=Cenarchaeum symbiosum
           GN=CENSYa_0182 PE=4 SV=1
          Length = 519

 Score =  263 bits (671), Expect = 6e-68,   Method: Compositional matrix adjust.
 Identities = 182/545 (33%), Positives = 275/545 (50%), Gaps = 49/545 (8%)

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           W TL H+G+ FPP ++    K+  KGK V+LT  QEE+A  +A  +DT Y     F++NF
Sbjct: 3   WKTLQHSGIHFPPEHEVKGFKIKVKGKQVNLTPLQEEMAYQWAKKKDTPYAQDKVFQKNF 62

Query: 416 WNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXX----XXXXXXXXXXXXXXXXXXXXXXX 471
             D+ K LG   +    KD DF+  Y                                  
Sbjct: 63  ARDFAKELGIKLL---YKDLDFSEAYRLVDMEKDKKDMMTKEEKKEIAAKRKEIREGLKA 119

Query: 472 XXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECP 531
               A++DG + ++ ++  EPPG+F GRG+HP  GK KRRI P D+V+N+G  A  P   
Sbjct: 120 KYGIAVMDGKEVEIASYMAEPPGIFIGRGKHPLRGKWKRRIGPQDVVLNMGTKAKAP--- 176

Query: 532 IPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYI 591
            PG +WK+I H+    W+A W D +  K  KYV+LA ++ LK + D+ KYEKA  L   I
Sbjct: 177 -PG-KWKKIVHEKDGIWIAKWTDNLVKKD-KYVWLADTAGLKQERDRSKYEKAVALSKKI 233

Query: 592 GNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTRE 651
           G I A   KD  SKD    +IA A YLI + A+R G+EKD DEADTVG  TL+ E++ R 
Sbjct: 234 GEIEAKIVKDMKSKDPKISKIATACYLIYRTAMRVGDEKDKDEADTVGATTLRKEHI-RI 292

Query: 652 APNKLKFNFLGKDSIKYENTVEV---ELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHL 708
           +   ++F+FLGKDSI++   ++V   +      +    K  K  D++F  + +S +N + 
Sbjct: 293 SDGVIEFDFLGKDSIRWNEKLKVTGDDEQFSRNLQGLVKSIKPKDEIFKDIRSSDVNRYY 352

Query: 709 KELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVY--QHANKQVAIICNHQRSV 766
             ++ G+TAKVFRT+ AS  + + L K+ K         +Y  + AN + AI+CNH+R+V
Sbjct: 353 SGIVKGVTAKVFRTYLASKKVSEYLRKNDKIRSKSAFFKLYHAKSANLEAAIMCNHKRTV 412

Query: 767 SKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKIS 826
            K+    + +  E L + +                               ++   +K+  
Sbjct: 413 PKTFKKALEKKKETLKKAKG------------------------------ATPKTDKQKE 442

Query: 827 QTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
           +   +IEK+   +K  ++ +   +GTS  NY+DPRI  AW        EK++  +L  KF
Sbjct: 443 RKKERIEKIGLQIKLAQNTRDYNVGTSLRNYIDPRIFKAWTDEVGAEWEKLYTTALQRKF 502

Query: 887 TWAMD 891
            W  D
Sbjct: 503 LWVRD 507


>B3L6G4_PLAKH (tr|B3L6G4) Topoisomerase I, putative OS=Plasmodium knowlesi
           (strain H) GN=PKH_102240 PE=4 SV=1
          Length = 924

 Score =  250 bits (638), Expect = 5e-64,   Method: Compositional matrix adjust.
 Identities = 132/311 (42%), Positives = 176/311 (56%), Gaps = 17/311 (5%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H + + YK   ++L    EE+AT +  +  +DY  K+KF  N
Sbjct: 189 QWHYLEHRGLIFSPPYVQHHIPIFYKSIKLELNEKAEELATYWCSVIGSDYCTKEKFILN 248

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L K+++I+             N +  DF PI D                   
Sbjct: 249 FFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDFMPIKDHLVKLREEKLNRTKEEKEE 308

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 309 EKKLRSEKELPHTYALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 368

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP+P     + G  W +I HDN VTWLA++ D IN +L KY FL+A S  KG  D  
Sbjct: 369 SKDAPVPRLYGDMCGHSWGDIYHDNKVTWLAYYKDSINDQL-KYTFLSAQSKFKGYKDFL 427

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTV 638
           KYE AR LK  +  IR  Y     SK+I ++Q+  A YLID LALR G EKD D+EADTV
Sbjct: 428 KYENARKLKSCVHKIREDYKHKMKSKNILEKQLGTAVYLIDFLALRVGGEKDIDEEADTV 487

Query: 639 GCCTLKVENVT 649
           GCC+L+VE+V+
Sbjct: 488 GCCSLRVEHVS 498



 Score =  133 bits (334), Expect = 8e-29,   Method: Compositional matrix adjust.
 Identities = 71/171 (41%), Positives = 103/171 (60%), Gaps = 13/171 (7%)

Query: 741 DVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARX 800
           +V E I  + +AN++VAI+CNHQRSV K HDT M+++ ++++     +KE +  L   + 
Sbjct: 754 NVNELINFFNNANREVAILCNHQRSVPKQHDTAMSKIKKQIEIYSEDIKEYKKYLQYLKK 813

Query: 801 XXXXXXXXXXXX-------------XXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKT 847
                                      N+  E+ +KK+     K+E+++  MK ++D KT
Sbjct: 814 GTKEESFTFVSKVVALDGSLRPNKVKENMKEESCKKKLIALIKKVEQLKHQMKVRDDNKT 873

Query: 848 VALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           +ALGTSKINY+DPRITVA+CKR E+PIEKIFN+SL  KF WAM V  +F F
Sbjct: 874 IALGTSKINYMDPRITVAFCKRFEIPIEKIFNRSLRLKFPWAMFVTKNFTF 924


>B3GD28_9CARA (tr|B3GD28) Topoisomerase I (Fragment) OS=Calosoma scrutator PE=4
           SV=1
          Length = 281

 Score =  246 bits (629), Expect = 4e-63,   Method: Compositional matrix adjust.
 Identities = 135/283 (47%), Positives = 184/283 (65%), Gaps = 11/283 (3%)

Query: 610 QQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLK-----FNFLGKD 664
           +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE++T       K     F+FLGKD
Sbjct: 3   RQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHITLHEQKDDKEYVVVFDFLGKD 62

Query: 665 SIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFN 724
           SI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTAKVFRT+N
Sbjct: 63  SIRYYNEVPVEKRVFKNLQLFMENKSAGDDLFDRLNTQIMNKHLNELMEGLTAKVFRTYN 122

Query: 725 ASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDE 783
           AS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV K H   M +L EK+++
Sbjct: 123 ASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKGHAKSMEKLKEKIEQ 182

Query: 784 LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKE 843
            +  + E+   +  A+                +  +  +K + +   ++ K++     K+
Sbjct: 183 KKDTISEMERQVQDAQRAAKRGSVKEK-----VVYDKKKKALEKLKDQLVKLEVQETDKD 237

Query: 844 DLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
           + K++ALGTSK+NYLDPRI+VAWCK++ VPIEKI+NK+   KF
Sbjct: 238 ENKSIALGTSKLNYLDPRISVAWCKKYGVPIEKIYNKTQRDKF 280


>B3GD30_METCO (tr|B3GD30) Topoisomerase I (Fragment) OS=Metrius contractus PE=4
           SV=1
          Length = 281

 Score =  246 bits (627), Expect = 7e-63,   Method: Compositional matrix adjust.
 Identities = 135/283 (47%), Positives = 185/283 (65%), Gaps = 11/283 (3%)

Query: 610 QQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLK-----FNFLGKD 664
           +Q AVA Y ID+LALRAGNEKD+D+ADTVGCC+L+VE+++       K     F+FLGKD
Sbjct: 3   RQRAVALYFIDRLALRAGNEKDEDQADTVGCCSLRVEHISLHEQKDGKEYVTVFDFLGKD 62

Query: 665 SIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFN 724
           SI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTAKVFRT+N
Sbjct: 63  SIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTQIMNKHLNELMDGLTAKVFRTYN 122

Query: 725 ASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDE 783
           AS TL   L++ T  D  + EKI+ Y  AN+ VAI+CNHQRSV K H   M +L EK+D+
Sbjct: 123 ASWTLQQQLDELTNADDTLAEKILSYNRANRAVAILCNHQRSVPKGHQKSMEKLKEKIDQ 182

Query: 784 LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKE 843
                KE  TD+ R +                +  +  +K + +   ++ K++     ++
Sbjct: 183 ----KKENITDMQR-QVKDAQKDAKHGSVKEKVVYDKKKKALERLRDQLMKLEVQETDRD 237

Query: 844 DLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
           + K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 238 ENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 280


>A5KB33_PLAVI (tr|A5KB33) Topoisomerase I, putative OS=Plasmodium vivax
           GN=PVX_098085 PE=3 SV=1
          Length = 931

 Score =  243 bits (620), Expect = 5e-62,   Method: Compositional matrix adjust.
 Identities = 131/311 (42%), Positives = 172/311 (55%), Gaps = 17/311 (5%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H + + YK   + L    EE+AT +  +  +DY  K+KF  N
Sbjct: 189 QWHYLEHRGLIFSPPYVQHNIPIFYKSIKLQLNEKAEELATYWCSVIGSDYCTKEKFILN 248

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L K+++I+             N K  DF PI D                   
Sbjct: 249 FFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDFMPIKDHLVKLREEKLNRTKEEKEE 308

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 309 EKKLRSEKELPYTYALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 368

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP+P     + G  W +  HDN VTWLA++ D IN +L KY FL+A S  KG  D  
Sbjct: 369 SKDAPVPRLYDDMCGHCWGDTYHDNKVTWLAYYKDSINDQL-KYTFLSAQSKFKGYKDFL 427

Query: 580 KYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD-DDEADTV 638
           KYE AR LK  +  IR  Y     +K I  +Q+  A YLID LALR G EKD D+EADTV
Sbjct: 428 KYENARKLKSCVHKIREDYRHKMRNKSILDKQLGTAVYLIDFLALRVGGEKDIDEEADTV 487

Query: 639 GCCTLKVENVT 649
           GCC+L+VE+V+
Sbjct: 488 GCCSLRVEHVS 498



 Score =  132 bits (331), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 71/171 (41%), Positives = 106/171 (61%), Gaps = 13/171 (7%)

Query: 741 DVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRL-------NEKLDELQAVLKELRT 793
           +V E I  + +AN++VAI+CNHQRSV K HD+ M+++       +E + E +  L+ L+ 
Sbjct: 761 NVNELINFFNNANREVAILCNHQRSVPKQHDSAMSKIKKQIEIYSEDIKEYKKYLQYLKK 820

Query: 794 DLDR------ARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKT 847
            ++       ++               N+  E+ +KK+     K+E+++  MK ++D KT
Sbjct: 821 GMNEQSFTFVSKVVALDGSLRPNKVKENMKEESCKKKLIALIKKVEQLKHQMKVRDDNKT 880

Query: 848 VALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDVDPDFRF 898
           +ALGTSKINY+DPRITVA+CKR E+PIEKIFN+SL  KF WAM V  +F F
Sbjct: 881 IALGTSKINYMDPRITVAFCKRFEIPIEKIFNRSLRLKFPWAMFVTKNFTF 931



 Score = 89.4 bits (220), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 43/80 (53%), Positives = 59/80 (73%)

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           L F+FLGKDSI+Y NTV+++   Y  ++ F K K   + +FD ++ SKLN +LKE+MP L
Sbjct: 582 LTFDFLGKDSIRYFNTVKLDKQAYINMIIFCKKKHKDEGVFDQINCSKLNDYLKEIMPTL 641

Query: 716 TAKVFRTFNASITLDDMLNK 735
           +AKVFRT+NASITLD  L +
Sbjct: 642 SAKVFRTYNASITLDQQLKR 661


>A0CF77_PARTE (tr|A0CF77) Chromosome undetermined scaffold_174, whole genome
           shotgun sequence OS=Paramecium tetraurelia
           GN=GSPATT00037883001 PE=3 SV=1
          Length = 725

 Score =  241 bits (615), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 125/294 (42%), Positives = 170/294 (57%), Gaps = 5/294 (1%)

Query: 356 WTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKENF 415
           W  L H+GV+FPP Y+ H V ++Y GK + LT +QEE+ T +A    + Y  K+ +++NF
Sbjct: 45  WRYLEHHGVLFPPFYKRHNVGLIYNGKLITLTEEQEELCTYWAQSIGSPYENKEIYRKNF 104

Query: 416 WNDWRKLLGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXW 475
                 L+        L   DFT I +                                +
Sbjct: 105 ----ESLMQTKFEGFQLDKADFTKIREHLEQQRLLRLNKSDEQKKQEKLERDQRELFYGY 160

Query: 476 AIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPECPIPGE 535
           A+VDG  E+VGN+ +E P LF+GRGEHPK G LK RI P ++ +N+   AP+P+C +PG 
Sbjct: 161 ALVDGCLERVGNYTLEQPTLFKGRGEHPKAGLLKARIFPEELTVNLSTQAPVPQCKLPGH 220

Query: 536 RWKEIRHDNTVTWL-AFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDYIGNI 594
            W +I H N VTWL ++ +  I     KYV  AA+S  K  +DK KYEKAR LK+ I  I
Sbjct: 221 SWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYEKARRLKNQIDQI 280

Query: 595 RAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 648
           R  YTK   S  I ++Q+  ATYLIDKLALR GN+KD+DEADTVGCC+L+VE++
Sbjct: 281 RENYTKKLQSDSIKERQLGTATYLIDKLALRVGNDKDEDEADTVGCCSLRVEHI 334


>Q9D6H0_MOUSE (tr|Q9D6H0) Putative uncharacterized protein OS=Mus musculus
           GN=Top1mt PE=2 SV=1
          Length = 295

 Score =  237 bits (604), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 133/300 (44%), Positives = 192/300 (64%), Gaps = 13/300 (4%)

Query: 607 ITKQQIAVATYLIDKLALRAGNEKDDDE-ADTVGCCTLKVENVTREAP-----NKLKFNF 660
           + K+Q+AVA Y IDKLALR GNEK++ E ADTVGCC+L+VE++   AP     + ++ +F
Sbjct: 1   MKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHIRLHAPAGGQEHVVELDF 60

Query: 661 LGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVF 720
           LGKDSI+Y+N V VE  V+  +  F +DK   DDLFD L TS LN HL++LM GLTAKVF
Sbjct: 61  LGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDLFDALTTSSLNKHLQDLMEGLTAKVF 120

Query: 721 RTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNE 779
           RT+NAS+TL + L   T+  D V  K++ Y  AN+ VA++CNHQR+V K+ +  M  L +
Sbjct: 121 RTYNASVTLQEQLRVLTRAEDSVTCKVLAYNRANRAVAVLCNHQRAVPKTFEKSMQTLQK 180

Query: 780 KLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDM 839
           K++  +A + E + +L +A                  S    ++++ +   ++ ++    
Sbjct: 181 KIETKKAQVAEAQVELQKAETDLRMRGDSKPK-----SFLQKQRRLLKLEEQLARLCAKA 235

Query: 840 KTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMD-VDPDFRF 898
             KE+ K VALGT+K+NYLDPRI++AWCKR  VP+EKI+NK+   +F WA +    DF F
Sbjct: 236 TDKEENKQVALGTAKLNYLDPRISIAWCKRFGVPVEKIYNKTQRERFAWAFNQAGEDFEF 295


>B3GD25_AMPLE (tr|B3GD25) Topoisomerase I (Fragment) OS=Amphizoa lecontei PE=4
           SV=1
          Length = 268

 Score =  234 bits (597), Expect = 2e-59,   Method: Compositional matrix adjust.
 Identities = 132/271 (48%), Positives = 174/271 (64%), Gaps = 11/271 (4%)

Query: 610 QQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLK-----FNFLGKD 664
           +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE++        K     F+FLGKD
Sbjct: 3   RQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIELHEQKDDKEFVVVFDFLGKD 62

Query: 665 SIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFN 724
           SI+Y N V VE  V+  +  F ++K   DDLFD L+T  +N HL ELM GLTAKVFRTFN
Sbjct: 63  SIRYYNEVPVEKRVFKNLQLFMENKAPADDLFDRLNTQIMNKHLNELMDGLTAKVFRTFN 122

Query: 725 ASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDE 783
           AS TL   L++ T  D  + EKI+ Y  AN+ VAI+CNHQRSV K H   M +L EK+D+
Sbjct: 123 ASYTLQQQLDELTNADDTLSEKILSYNRANRAVAILCNHQRSVPKGHQKTMEKLKEKIDQ 182

Query: 784 LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKE 843
            +  + E++  +  A+                   + LE+   Q   K+E  + D   K+
Sbjct: 183 KREQITEMQKQVKDAQRDAQHGSVKEKVVLDK-KKKGLERLKDQL-VKLEVQETD---KD 237

Query: 844 DLKTVALGTSKINYLDPRITVAWCKRHEVPI 874
           + K++ALGTSK+NYLDPRI+VAWCK++EVPI
Sbjct: 238 ENKSIALGTSKLNYLDPRISVAWCKKYEVPI 268


>B3GD27_9COLE (tr|B3GD27) Topoisomerase I (Fragment) OS=Macrogyrus oblongus PE=4
           SV=1
          Length = 263

 Score =  226 bits (576), Expect = 7e-57,   Method: Compositional matrix adjust.
 Identities = 124/266 (46%), Positives = 168/266 (63%), Gaps = 11/266 (4%)

Query: 610 QQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNKLK-----FNFLGKD 664
           +Q AVA Y IDKLALRAGNEKD+D+ADTVGCC+L+VE++        K     F+FLGKD
Sbjct: 3   RQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIELHEQKDDKEYVVVFDFLGKD 62

Query: 665 SIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFN 724
           SI+Y N V VE  V+  +  F ++K  GDDLFD L+T+ +N HL ELM GLTAKVFRT+N
Sbjct: 63  SIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTAIMNKHLNELMEGLTAKVFRTYN 122

Query: 725 ASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDE 783
           AS TL   L++ T D D V EKI+ Y  AN+ VAI+CNHQRSV K H   M +L EK+++
Sbjct: 123 ASWTLQQQLDELTNDDDTVAEKILSYNRANRAVAILCNHQRSVPKGHQKTMEKLKEKIEQ 182

Query: 784 LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKE 843
            +  + E++  +  A+                      + K      ++++  +D     
Sbjct: 183 KREQINEMQRQVKDAQRDARNGSVKEKMVFDKKKKALEKLKEQMIRLEVQETDKD----- 237

Query: 844 DLKTVALGTSKINYLDPRITVAWCKR 869
           + K++ALGTSK+NYLDPRI+VAWCK+
Sbjct: 238 ENKSIALGTSKLNYLDPRISVAWCKK 263


>Q5BXE0_SCHJA (tr|Q5BXE0) SJCHGC03473 protein (Fragment) OS=Schistosoma japonicum
           PE=2 SV=2
          Length = 238

 Score =  216 bits (549), Expect = 8e-54,   Method: Compositional matrix adjust.
 Identities = 117/222 (52%), Positives = 150/222 (67%), Gaps = 6/222 (2%)

Query: 566 LAASSSLKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALR 625
           L  SS LKG+ D +KYE AR L   I  IRA Y  DF  K++  +Q AVA Y IDKLALR
Sbjct: 1   LNPSSRLKGEKDWKKYETARCLHKVIDKIRADYRADFKHKEMRIRQRAVALYFIDKLALR 60

Query: 626 AGNEKDDDEADTVGCCTLKVENVTRE-----APNKLKFNFLGKDSIKYENTVEVELPVYN 680
           AGNEKD+DEADTVGCC+L+ E++         P  ++F+FLGKDSI+Y+N+V V   V+ 
Sbjct: 61  AGNEKDEDEADTVGCCSLRYEHIKLHEELNGQPYVVEFDFLGKDSIRYQNSVSVPKRVFK 120

Query: 681 AILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTK-D 739
            +  F K+KK  DDLFD L+TS LN +L+ELM GLTAKVFRT+NAS TL++ L + T  D
Sbjct: 121 NVKLFLKNKKENDDLFDRLNTSVLNQYLRELMDGLTAKVFRTYNASRTLEEQLERLTNPD 180

Query: 740 GDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKL 781
                K++ Y  AN+ VA++CNHQRSV KS    M  L +K+
Sbjct: 181 DPPHAKLLAYNRANRAVAVLCNHQRSVPKSFAKSMENLQKKV 222


>Q6IQI8_DANRE (tr|Q6IQI8) Top1l protein (Fragment) OS=Danio rerio GN=top1l PE=2
           SV=1
          Length = 469

 Score =  215 bits (547), Expect = 1e-53,   Method: Compositional matrix adjust.
 Identities = 109/252 (43%), Positives = 145/252 (57%), Gaps = 6/252 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+ + EEVAT ++ M D +Y  KD F+
Sbjct: 209 KWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFR 268

Query: 413 ENFWNDWRKLLGKNHV--IQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+ DWRK +       I +L  CDF+ + ++                           
Sbjct: 269 KNFFKDWRKEMTSEEKSKITDLNKCDFSNMSEYFKAQSEARKAMTKEEKLKIKEENERIL 328

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+D  KE++ NFR+EPPGLFRGRG+HPKMG LKRRIRP DI+IN  KD+  P  
Sbjct: 329 QEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHP-T 387

Query: 531 PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARMLKDY 590
           P PG +WKE+RHDN VTWL  W + I   + KY+ L  SS +KG+ D +KYE AR LK  
Sbjct: 388 PPPGTKWKEVRHDNKVTWLVSWTENIQGSI-KYIMLNPSSRIKGEKDWQKYETARRLKKC 446

Query: 591 IGNIRAAYTKDF 602
           +  IR+ Y  D+
Sbjct: 447 VDRIRSQYRDDW 458


>B6JVY3_SCHJP (tr|B6JVY3) DNA topoisomerase I OS=Schizosaccharomyces japonicus
           yFS275 GN=SJAG_05193 PE=4 SV=1
          Length = 654

 Score =  201 bits (511), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 93/214 (43%), Positives = 126/214 (58%), Gaps = 9/214 (4%)

Query: 351 DGQKKWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLK 408
           DG KKW TL HNGV+FPP Y+P    VKMLY GKP+DL    EEVA  +  + ++D+   
Sbjct: 236 DG-KKWNTLEHNGVMFPPEYEPLPSHVKMLYNGKPIDLPPAAEEVAGFFGALLESDHAQN 294

Query: 409 DKFKENFWNDWRKL-----LGKNHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXX 463
             F++NF+ D++ +     +    + +    CDF P++++                    
Sbjct: 295 PTFQKNFFRDFQAVCKEAGMKSADIPKEFNSCDFRPMFEYFESLKEAKKNMSKEEKKELK 354

Query: 464 XXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGK 523
                      W ++DG KEKVGNFR+EPPGLFRGRG HPK G LKRR+ P  I INIGK
Sbjct: 355 KKKEEEEEKFKWCLLDGRKEKVGNFRIEPPGLFRGRGSHPKTGTLKRRVYPEQITINIGK 414

Query: 524 DAPIPECPIPGERWKEIRHDNTVTWLAFWNDPIN 557
            A +PE P+PG +W E+RHD+ VTWLA W++ +N
Sbjct: 415 GAKVPE-PLPGHKWAEVRHDDQVTWLAMWHENVN 447



 Score = 84.3 bits (207), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 51/128 (39%), Positives = 75/128 (58%), Gaps = 19/128 (14%)

Query: 775 TRLNEKL---DELQAVL-KELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNA 830
           + L E+L   DEL+A L +ELRT    A                  S+E LEK++ + + 
Sbjct: 542 SELEERLKAADELKAKLDEELRTGAVEAGRS---------------SNEQLEKRLIKMDE 586

Query: 831 KIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAM 890
           +I+ M   +  K++ KT ALGTSKINY+DPR+T + CKR  +PIEK+F+K++  KF WA 
Sbjct: 587 RIKVMSNSIIDKDENKTTALGTSKINYIDPRLTFSLCKRENIPIEKLFSKTIRDKFNWAA 646

Query: 891 DVDPDFRF 898
           D   D+ +
Sbjct: 647 DTPADWNW 654


>B3GD23_9DYTI (tr|B3GD23) Topoisomerase I (Fragment) OS=Laccophilus pictus PE=4
           SV=1
          Length = 247

 Score =  198 bits (504), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 108/231 (46%), Positives = 152/231 (65%), Gaps = 8/231 (3%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL + L+K T   D V EKI+ Y  AN+ VAI+CNHQRSV K H   M +
Sbjct: 82  KVFRTYNASHTLQEQLDKLTNAEDSVTEKILSYNRANRAVAILCNHQRSVPKGHQKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDL-DRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKM 835
           L EK+D+ +  ++E++  + D AR                L  +  +K + +   +++K+
Sbjct: 142 LKEKIDQKREQIEEMQRQVKDAARDAKHGSVKEK------LVHDKKKKSLDRLKEQLKKL 195

Query: 836 QRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
           +     +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 196 EVQETDRDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B4LSA9_DROVI (tr|B4LSA9) GJ16237 OS=Drosophila virilis GN=GJ16237 PE=4 SV=1
          Length = 557

 Score =  196 bits (498), Expect = 7e-48,   Method: Compositional matrix adjust.
 Identities = 153/548 (27%), Positives = 245/548 (44%), Gaps = 80/548 (14%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL HNG +FP  Y+  P  V  LY   P++LT   EEVAT YA +  T ++   +F 
Sbjct: 67  KWQTLEHNGPLFPGAYERLPENVHFLYDNCPIELTEQAEEVATFYAKVLGTPFVELSEFN 126

Query: 413 ENFWNDWRKLLGKNHVIQ--NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           ENF+ D+R  L     +   +   C+F  I+ +                           
Sbjct: 127 ENFFKDFRSCLSVEQRLHFTSFDLCNFQKIHQY-----------LEEQQEARSQQELEED 175

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGR-GEHPKMGKLKRRIRPSDIVINIGKDAPIPE 529
               +  +DG + ++  FR++PPGL   R G    MG ++ R+ P DI+IN  + A  P 
Sbjct: 176 ERYGYCYIDGERHRINQFRIKPPGLCCPRKGYSLTMGMIRPRVLPEDIMINCDEYAEPPA 235

Query: 530 CPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSD-KEKYEKARMLK 588
            P PG RW+++ HD +V+WL  W+D ++   + YV      S + +   + + E AR L+
Sbjct: 236 -PPPGHRWRQVVHDRSVSWLYSWHDLVSGNTY-YVRARIDQSKRYRLPLRNQLETARRLQ 293

Query: 589 DYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 648
            ++ +IR  Y + ++S     +Q +VA Y ID+LA+     +D ++ D V  C L+VEN+
Sbjct: 294 QHLPSIRREYRQLWSSDQWLVRQRSVALYCIDQLAMTC---EDPEQPDKVTLCDLRVENL 350

Query: 649 TREA-----PNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSK 703
                     N ++      +  +   +V V+  V+  +  F   K+  D + + L T  
Sbjct: 351 QLHPRLAGKKNVVRLQARKSNRQRVYRSVCVQPEVFYNLRVFVSGKEPNDLVLEELTTQL 410

Query: 704 LNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIIC-NH 762
           LN HL+ LM GLT+ +F   NAS  L+  L +  +   +  +++ Y  A K+V   C N 
Sbjct: 411 LNEHLEYLMDGLTSHIFCICNASQLLEQRLKEVPRKASLTVQLLAYNQALKEVHSFCSNR 470

Query: 763 QRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALE 822
           QR+V+     +  RL  +                                  +   + L 
Sbjct: 471 QRNVAPLPAPKSFRLTRR---------------------------------NSTEEQRLL 497

Query: 823 KKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL 882
           K IS                  L T  L  + + YLDPRIT++WC R ++PI  I+  S 
Sbjct: 498 KSIS------------------LHTKPLVEATLIYLDPRITISWCLRCKIPISAIYMSSA 539

Query: 883 L-AKFTWA 889
           +  K  WA
Sbjct: 540 IRKKLIWA 547


>B3GD22_9COLE (tr|B3GD22) Topoisomerase I (Fragment) OS=Chauliognathus opacus
           PE=4 SV=1
          Length = 247

 Score =  194 bits (493), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 105/230 (45%), Positives = 147/230 (63%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F + K+ GDDLFD L+T+ LN HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMEKKEPGDDLFDRLNTAILNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L+K T + D + EKI+ Y  AN+ VAI+CNHQR+V K H+  M +
Sbjct: 82  KVFRTYNASWTLQQQLDKLTNEDDSISEKILSYNRANRAVAILCNHQRAVPKGHEKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           + EK+D  +  +K+    +  A+                   E   K + +   ++ K++
Sbjct: 142 IKEKIDAKRQAIKDAERQVKDAQRDAKHGSVKEKTVY-----EKKRKLLERLKEQLTKLE 196

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                +++ KT+ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 197 IQETDRDENKTIALGTSKLNYLDPRISVAWCKKNDVPIEKIYNKTQRDKF 246


>B3GD31_9CARA (tr|B3GD31) Topoisomerase I (Fragment) OS=Sirdenus grayii PE=4 SV=1
          Length = 247

 Score =  193 bits (490), Expect = 6e-47,   Method: Compositional matrix adjust.
 Identities = 106/230 (46%), Positives = 149/230 (64%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  + EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDSLAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+D+ +  + + +  +  A+                L  E  +K + +   +++K++
Sbjct: 142 LKEKIDQKREQIADAQRQVKDAQKDAKHGSVKEK-----LVYEKKKKMLDKLKDQLKKLE 196

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                +++ KT+ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 197 VQETDRDENKTIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD21_9COLE (tr|B3GD21) Topoisomerase I (Fragment) OS=Prolixocupes lobiceps
           PE=4 SV=1
          Length = 229

 Score =  193 bits (490), Expect = 6e-47,   Method: Compositional matrix adjust.
 Identities = 105/237 (44%), Positives = 147/237 (62%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K G DDLFD L+TS LN HL ELM GLTA
Sbjct: 4   FDFLGKDSIRYYNEVPVEKRVFKNLQLFIENKSGEDDLFDRLNTSILNKHLNELMEGLTA 63

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EK++ Y  AN+ VA++CNHQRSV K H+  M +
Sbjct: 64  KVFRTYNASFTLQQQLDQLTNADDSVSEKMLSYNRANRAVAVLCNHQRSVPKGHEKSMEK 123

Query: 777 LNEKLD-------ELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+        E++  +K+ + D  R                  L  + ++ ++++T+
Sbjct: 124 LKEKIGTKRDQIAEMEKQVKDAQKDAKRGSVKEKVVYDKKKKHLERLREQLVKLEVAETD 183

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K++ALGTSK+NYLDPRITVAWCK++ VPIEK++NK+   KF
Sbjct: 184 ------------RDENKSIALGTSKLNYLDPRITVAWCKKYGVPIEKVYNKTQRDKF 228


>B3GD43_9CARA (tr|B3GD43) Topoisomerase I (Fragment) OS=Bembidion chalceum PE=4
           SV=1
          Length = 247

 Score =  192 bits (487), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 107/237 (45%), Positives = 144/237 (60%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEK-------LDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK       +DE Q  +K+ + D                     L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKREQIDEAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLERLKEQLIKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B6NV09_BRAFL (tr|B6NV09) Putative uncharacterized protein (Fragment)
           OS=Branchiostoma floridae GN=BRAFLDRAFT_237079 PE=4 SV=1
          Length = 299

 Score =  192 bits (487), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 128/325 (39%), Positives = 183/325 (56%), Gaps = 32/325 (9%)

Query: 572 LKGQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKD 631
           L+G+ D  KYE AR L   +  IRA Y +++ SK++  +Q AVA Y IDKLALRAGNEKD
Sbjct: 1   LQGEKDWMKYETARKLHKCVDRIRAQYREEWKSKEMRIRQRAVALYFIDKLALRAGNEKD 60

Query: 632 DDE-ADTVGCCTLKVE--NVTREAPNK---LKFNFLGKDSIKYENTVEVELPVYNAILKF 685
            DE ADTVGCC+L+VE  N+ RE   K   ++F+FLGKDSI+Y N V VE  V+  ++ +
Sbjct: 61  SDEAADTVGCCSLRVEHINLHREHEGKEFVVEFDFLGKDSIRYHNFVAVEKKVFKNLV-W 119

Query: 686 QKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEK 745
             D  G   L   L +  L   ++ L  GL   V +   ++   D   +   +D  V  K
Sbjct: 120 SPDHTGSCLL---LGSYLLCCGVQGLQVGLVCTVKQCLCSA---DPPFSPPGEDS-VAAK 172

Query: 746 IVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXX 805
           I+ Y  AN+ VAI+CNHQRSV K+ +  M+ L  K+     +++     L   R      
Sbjct: 173 ILSYNRANRAVAILCNHQRSVPKTFEKSMSNLQAKVGRKHHLIRICHIYLATCR------ 226

Query: 806 XXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVA 865
                     +  E  +K++ +   ++ K++     KE+ K +ALGTSK+NYLDPRI+VA
Sbjct: 227 ---------QMMLERKKKQMERLEEQLMKLEVQATDKEENKEIALGTSKLNYLDPRISVA 277

Query: 866 WCKRHEVPIEKIFNKSLLAKFTWAM 890
             K H   +EKI+NK+   KF WA+
Sbjct: 278 CGKSH---VEKIYNKTQRDKFAWAL 299


>B3GD45_9CARA (tr|B3GD45) Topoisomerase I (Fragment) OS=Bembidion rufotinctum
           PE=4 SV=1
          Length = 247

 Score =  191 bits (486), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 104/230 (45%), Positives = 149/230 (64%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  ++E +  +  A+                +  +  +K + +   ++ K++
Sbjct: 142 LKEKIEQKREQIEEAQKQVKDAQRDAKHGSVKEK-----VVYDKKKKMLERLKEQLIKLE 196

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 197 VQETDRDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD39_9CARA (tr|B3GD39) Topoisomerase I (Fragment) OS=Bembidion integrum PE=4
           SV=1
          Length = 247

 Score =  191 bits (486), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 104/230 (45%), Positives = 149/230 (64%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  ++E +  +  A+                +  +  +K + +   ++ K++
Sbjct: 142 LKEKIEQKREQIEEAQKQVKDAQRDAKHGSVKEK-----VVYDKKKKMLERLKEQLIKLE 196

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 197 VQETDRDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD41_9CARA (tr|B3GD41) Topoisomerase I (Fragment) OS=Bembidion inaequale PE=4
           SV=1
          Length = 247

 Score =  190 bits (482), Expect = 5e-46,   Method: Compositional matrix adjust.
 Identities = 104/230 (45%), Positives = 150/230 (65%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T   D V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNAEDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  +++ +  +  A+                   + + +++ +   K+E ++
Sbjct: 142 LKEKIEQKREQIEDAQKQVKDAQRDAKHGSVKEKVVYD--KKKKMLERLKEQLIKLEVLE 199

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
            D   +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 200 TD---RDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD42_9CARA (tr|B3GD42) Topoisomerase I (Fragment) OS=Bembidion inaequale PE=4
           SV=1
          Length = 247

 Score =  190 bits (482), Expect = 5e-46,   Method: Compositional matrix adjust.
 Identities = 103/230 (44%), Positives = 149/230 (64%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  +++ +  +  A+                +  +  +K + +   ++ K++
Sbjct: 142 LKEKIEQKREQIEDAQKQVKDAQRDAKHGSVKEK-----VVYDKKKKMLERLKEQLIKLE 196

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 197 VQETDRDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD37_9CARA (tr|B3GD37) Topoisomerase I (Fragment) OS=Bembidion mandibulare
           PE=4 SV=1
          Length = 247

 Score =  189 bits (481), Expect = 6e-46,   Method: Compositional matrix adjust.
 Identities = 106/230 (46%), Positives = 148/230 (64%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTQIMNKHLTELMDGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  + EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTIAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  + + +  +  A+                   + LE ++ +   K+E M+
Sbjct: 142 LKEKIEQKREQITDAQKQVKDAQRDAKHGSVKEKVVYDK-KKKTLE-RLKEQLMKLEVME 199

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
            D   +++ K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 200 TD---RDENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD38_9CARA (tr|B3GD38) Topoisomerase I (Fragment) OS=Bembidion concolor PE=4
           SV=1
          Length = 247

 Score =  189 bits (480), Expect = 8e-46,   Method: Compositional matrix adjust.
 Identities = 105/237 (44%), Positives = 145/237 (61%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        Q  +K+ + D                     L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKREQITDAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLERLKEQLIKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD34_9CARA (tr|B3GD34) Topoisomerase I (Fragment) OS=Bembidion umbratum PE=4
           SV=1
          Length = 247

 Score =  189 bits (480), Expect = 9e-46,   Method: Compositional matrix adjust.
 Identities = 105/237 (44%), Positives = 144/237 (60%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        Q  +K+ + D                     L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKREQITDAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLERLKEQLIKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTXRDKF 246


>B3GD33_9CARA (tr|B3GD33) Topoisomerase I (Fragment) OS=Bembidion transversale
           PE=4 SV=1
          Length = 247

 Score =  189 bits (480), Expect = 9e-46,   Method: Compositional matrix adjust.
 Identities = 105/237 (44%), Positives = 144/237 (60%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        Q  +K+ + D                     L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKREQITDAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLERLKEQLIKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRHKF 246


>B3GD32_9CARA (tr|B3GD32) Topoisomerase I (Fragment) OS=Asaphidion yukonense PE=4
           SV=1
          Length = 247

 Score =  189 bits (480), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 105/230 (45%), Positives = 142/230 (61%), Gaps = 6/230 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+D+ +  + + +  +  A+                      + K      ++++  
Sbjct: 142 LKEKIDQKREQITDAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLEKLKEQLIKLEVQETD 201

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
           RD     + K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 RD-----ENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD36_9CARA (tr|B3GD36) Topoisomerase I (Fragment) OS=Bembidion rapidum PE=4
           SV=1
          Length = 247

 Score =  188 bits (478), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 105/237 (44%), Positives = 144/237 (60%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        Q  +K+ + D                     L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKREQIVDAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLERLKEQLVKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD35_9CARA (tr|B3GD35) Topoisomerase I (Fragment) OS=Bembidion plagiatum PE=4
           SV=1
          Length = 247

 Score =  188 bits (478), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 105/237 (44%), Positives = 144/237 (60%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV KSH   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNADDTVAEKILSYNRANRAVAILCNHQRSVPKSHAKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        Q  +K+ + D                     L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKREQIVDAQKQVKDAQRDAKHGSVKEKVVYDKKKKMLERLKEQLIKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K +ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKAIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKTQRDKF 246


>B3GD29_9CARA (tr|B3GD29) Topoisomerase I (Fragment) OS=Scaphinotus petersi PE=4
           SV=1
          Length = 247

 Score =  188 bits (478), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 103/237 (43%), Positives = 145/237 (61%), Gaps = 20/237 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTQIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTKDGDV-GEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T + D   EKI+ Y  AN+ VAI+CNHQRSV K H   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTNEDDTEAEKILSYNRANRAVAILCNHQRSVPKGHAKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        +  +K+ + D  R                  L  + ++ ++ +T+
Sbjct: 142 LKEKIEQKKDAISDAEQQVKDAQRDAKRGSVKEKVVYDKKKKTLERLKDQLMKLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKF 886
                       +++ K++ALGTSK+NYLDPRI+VAWCK+++VPIEKI+NK+   KF
Sbjct: 202 ------------RDENKSIALGTSKLNYLDPRISVAWCKKYDVPIEKIYNKAQRDKF 246


>B4KJC7_DROMO (tr|B4KJC7) GI24443 OS=Drosophila mojavensis GN=GI24443 PE=4 SV=1
          Length = 555

 Score =  187 bits (474), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 147/546 (26%), Positives = 231/546 (42%), Gaps = 75/546 (13%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW TL HNG  FP  ++  P  VK  Y   PV+LT   EEVAT YA +  T ++   +F 
Sbjct: 64  KWQTLRHNGPCFPADHERLPADVKFYYDNCPVELTEQAEEVATFYAKLMKTAFVQMREFN 123

Query: 413 ENFWNDWRKLLGKNH--VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
           +NF+N++R  L +     I   + C+F  I  +                           
Sbjct: 124 QNFFNEFRSCLSEEQRRYITCFELCNFCDISQY-----------LECQREDEKERIAEEN 172

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGR-GEHPKMGKLKRRIRPSDIVINI--GKDAPI 527
               + +VDG   ++  FR+  PGL   R G    MG ++ R+ P D+VIN    ++ P 
Sbjct: 173 KLYGYCLVDGESRRITQFRISRPGLCCPRHGFSTTMGTIRPRVLPEDVVINCDENEEPPA 232

Query: 528 PECPIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKEKYEKARML 587
           P C   G  W  + HD TV W+  WND +   +        SS       ++  + AR L
Sbjct: 233 PPC---GHLWAAVVHDRTVRWVYAWNDIVTGCMHHAYPRNESSRRSRPPRRDLLDTARRL 289

Query: 588 KDYIGNIRAAYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVEN 647
           + ++ +IR  Y    +S++   +Q +VA Y ID+LA+    E+   E    G C   ++ 
Sbjct: 290 QQHLHHIRNEYQTLQSSENWLVRQRSVALYCIDQLAMSCDAEEVPAETTVCGLCVQNIKL 349

Query: 648 VTREAPNKLKFNFL-GKDSIKYENTVEVELP--VYNAILKFQKDKKGGDDLFDMLDTSKL 704
             R    +     L G    +        +P  ++  +  F   K+  + +F+ L+T  L
Sbjct: 350 CPRLGGQRNVLQLLAGNRDCRQREYKRSSVPPGIFYNLSVFICGKQPDELVFEELNTETL 409

Query: 705 NAHLKELMPGLTAKVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQR 764
           N HL  LM GLT+ VFR  NAS  L+D L K      + E++  Y  A K V + C  + 
Sbjct: 410 NEHLDFLMDGLTSSVFRICNASRLLEDRLIKIPLSATLCEQLTAYNKALKAVHMHCGFR- 468

Query: 765 SVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKK 824
                        + ++D L A+ +                                   
Sbjct: 469 -------------HRRIDPLPALKRPC--------------------------------A 483

Query: 825 ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF-NKSLL 883
           I + +A  ++  R ++    L+T  L  +   YLDPRIT++WC R E+P+  I+ N  + 
Sbjct: 484 IPRNSAAEQRKLRSIR----LQTKPLVEATFFYLDPRITISWCLRREIPLSSIYLNYGMR 539

Query: 884 AKFTWA 889
            K  WA
Sbjct: 540 KKLFWA 545


>B3GD20_9NEOP (tr|B3GD20) Topoisomerase I (Fragment) OS=Sialis sp. ALW-2008 PE=4
           SV=1
          Length = 234

 Score =  182 bits (461), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 101/218 (46%), Positives = 142/218 (65%), Gaps = 6/218 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+TS +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAAGDDLFDRLNTSIMNKHLNELMDGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL + L+  T + D + EKI+ Y  AN+ VAI+CNHQRSV K H   M +
Sbjct: 82  KVFRTYNASSTLQEQLDLLTNEDDTLSEKILSYNRANRAVAILCNHQRSVPKGHQKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  ++E++  +  A                +   +ALE+   Q   K+E  +
Sbjct: 142 LKEKIEQKREFIQEMQKXVKDA-AKDAKHGSVKEKVVHDKKKKALERLRDQL-MKLEVQE 199

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPI 874
            D   +++ K++ALGTSK+NYLDPRI+VAWCK+++VPI
Sbjct: 200 TD---RDENKSIALGTSKLNYLDPRISVAWCKKYDVPI 234


>Q5C1T3_SCHJA (tr|Q5C1T3) SJCHGC05060 protein (Fragment) OS=Schistosoma japonicum
           PE=2 SV=2
          Length = 330

 Score =  179 bits (454), Expect = 9e-43,   Method: Compositional matrix adjust.
 Identities = 86/202 (42%), Positives = 114/202 (56%), Gaps = 5/202 (2%)

Query: 355 KWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+  P  V   Y  KP+ L+   EEVA  YA M D DY  K+ F 
Sbjct: 129 KWKFLEHKGPLFAPPYERLPSSVHFHYDSKPMKLSDHAEEVAGFYARMLDHDYTTKEVFN 188

Query: 413 ENFWNDWRKLLGKNH--VIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
            NF++DW K + +     I++L  CDF  ++ +                           
Sbjct: 189 HNFFHDWVKTMNEEERRTIKSLSKCDFQEMHQYFLKLSEERKNRTKEEKQKIKEENLQIQ 248

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPEC 530
               + I+DG K+++GNFR+EPPGLFRGRG HPKMG LK+RI P D++IN  KD+ +P  
Sbjct: 249 NEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKVP-A 307

Query: 531 PIPGERWKEIRHDNTVTWLAFW 552
           P  G +WKE+RHDN+VTWLA W
Sbjct: 308 PPKGHKWKEVRHDNSVTWLACW 329


>B3GD24_9DYTI (tr|B3GD24) Topoisomerase I (Fragment) OS=Copelatus distinctus PE=4
           SV=1
          Length = 234

 Score =  179 bits (453), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 96/218 (44%), Positives = 140/218 (64%), Gaps = 6/218 (2%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K  GDDLFD L+T  +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAEGDDLFDRLNTQIMNKHLNELMDGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTKDGD-VGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL + L+  T + D V EKI+ Y  AN+ VAI+CNHQRSV K H   M +
Sbjct: 82  KVFRTYNASSTLQEQLDLLTNEDDSVTEKILSYNRANRAVAILCNHQRSVPKGHQKSMEK 141

Query: 777 LNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQ 836
           L EK+++ +  + E++  +  A                 +  +  +K + +   +++K++
Sbjct: 142 LKEKIEQKKEHIAEMQKQVKDA-----AKDAKHGSVKEKVVHDKKKKALERLKDQLKKLE 196

Query: 837 RDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPI 874
                +++ K++ALGTSK+NYLDPRI+VAWCK+++VPI
Sbjct: 197 VQETDRDENKSIALGTSKLNYLDPRISVAWCKKYDVPI 234


>Q4XMK5_PLACH (tr|Q4XMK5) Topoisomerase I, putative (Fragment) OS=Plasmodium
           chabaudi GN=PC000040.05.0 PE=4 SV=1
          Length = 429

 Score =  178 bits (452), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 99/249 (39%), Positives = 131/249 (52%), Gaps = 16/249 (6%)

Query: 355 KWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFKEN 414
           +W  L H G+IF PPY  H + + YK   ++L    EE+AT +  +  TDY  KDKF  N
Sbjct: 182 QWNYLEHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELATYWCSVIGTDYCTKDKFILN 241

Query: 415 FWNDWRKLLGKNHVIQ-------------NLKDCDFTPIYDWCXXXXXXXXXXXXXXXXX 461
           F+  +   L K+++I+             N K  DF  I +                   
Sbjct: 242 FFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDFMTIKEHLIKLRDERLNKTKEEKEE 301

Query: 462 XXXXXXXXXXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINI 521
                        +A+VD ++EK+ + + EPPGLFRGRGEHPK G LK+RI P D+VINI
Sbjct: 302 DKKIRMEKELPYTFALVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINI 361

Query: 522 GKDAPIPEC--PIPGERWKEIRHDNTVTWLAFWNDPINPKLFKYVFLAASSSLKGQSDKE 579
            KDAP P     + G  W +I HDN VTWLA++ D IN ++ KY FL+A S  KG  D  
Sbjct: 362 SKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYKDSINDQI-KYTFLSAQSKFKGYKDFL 420

Query: 580 KYEKARMLK 588
           KYE AR LK
Sbjct: 421 KYENARKLK 429


>B3GD26_9COLE (tr|B3GD26) Topoisomerase I (Fragment) OS=Dineutes sublineatus PE=4
           SV=1
          Length = 234

 Score =  177 bits (450), Expect = 3e-42,   Method: Compositional matrix adjust.
 Identities = 99/225 (44%), Positives = 135/225 (60%), Gaps = 20/225 (8%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y N V VE  V+  +  F ++K   DDLFD L+TS +N HL ELM GLTA
Sbjct: 22  FDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKAPADDLFDRLNTSIMNKHLNELMEGLTA 81

Query: 718 KVFRTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTR 776
           KVFRT+NAS TL   L++ T  D  V EKI+ Y  AN+ VAI+CNHQRSV K H   M +
Sbjct: 82  KVFRTYNASWTLQQQLDELTSADDTVAEKILSYNRANRAVAILCNHQRSVPKGHQKSMEK 141

Query: 777 LNEKLDE-------LQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTN 829
           L EK+++        Q  LK+ + D  R                  L  + +  ++ +T+
Sbjct: 142 LKEKIEQKREQVADAQRQLKDAQRDAKRGSVKERVVADKKKKQLDRLRDQLVRLEVQETD 201

Query: 830 AKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPI 874
                       +++ K++ALGTSK+NYLDPRI+VAWCK+++VPI
Sbjct: 202 ------------RDENKSIALGTSKLNYLDPRISVAWCKKYDVPI 234


>Q941M6_ORYSA (tr|Q941M6) Topoisomerase I (Fragment) OS=Oryza sativa PE=2 SV=1
          Length = 105

 Score =  165 bits (417), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 80/105 (76%), Positives = 92/105 (87%)

Query: 658 FNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTA 717
           F+FLGKDSI+Y NTVEVE  VY AI +FQ  K   DDLFD LDTSKLNAHLKEL+PGLTA
Sbjct: 1   FDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDLFDELDTSKLNAHLKELVPGLTA 60

Query: 718 KVFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNH 762
           KVFRT+NASITLD+ML+++TKDGDV +KIVVYQ ANK+VAI+CNH
Sbjct: 61  KVFRTYNASITLDEMLSQETKDGDVTQKIVVYQKANKEVAILCNH 105


>Q941M5_SPIOL (tr|Q941M5) Topoisomerase I (Fragment) OS=Spinacia oleracea PE=2
           SV=1
          Length = 102

 Score =  159 bits (402), Expect = 9e-37,   Method: Compositional matrix adjust.
 Identities = 78/102 (76%), Positives = 89/102 (87%)

Query: 660 FLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGLTAKV 719
           FLGKDSI+Y NTVEVE  VY AI +FQ  K   DDLFD LDTSKLNAHLKEL+PGLTAKV
Sbjct: 1   FLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDLFDELDTSKLNAHLKELVPGLTAKV 60

Query: 720 FRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICN 761
           FRT+NASITLD+ML+++TKDGDV +KIVVYQ ANK+VAI+CN
Sbjct: 61  FRTYNASITLDEMLSQETKDGDVTQKIVVYQKANKEVAILCN 102


>Q7YXA0_LEIMA (tr|Q7YXA0) DNA topoisomerase I subunit A (Fragment) OS=Leishmania
           major GN=top1a PE=4 SV=1
          Length = 200

 Score =  156 bits (395), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 71/159 (44%), Positives = 96/159 (60%), Gaps = 1/159 (0%)

Query: 352 GQKKWTTLVHNGVIFPPPYQPHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           G+++W TL HNGV+FPP Y+PH + + Y G+   +T ++EEVATM+AVM++ DY   + F
Sbjct: 42  GERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVF 101

Query: 412 KENFWNDWRKLLGK-NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXXX 470
             NF+  WR++LGK  H I+ L+ CDF PIY W                           
Sbjct: 102 WRNFFESWREILGKRQHPIRRLELCDFEPIYQWYLVQREKKLSRTKEEKEAIKEKQDAEA 161

Query: 471 XXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK 509
               + + DG +E+V NFRVEPPGLFRGRG+HP MGKLK
Sbjct: 162 EPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLK 200


>Q9BVT2_HUMAN (tr|Q9BVT2) Putative uncharacterized protein (Fragment) OS=Homo
           sapiens PE=2 SV=1
          Length = 176

 Score =  132 bits (332), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 6/180 (3%)

Query: 721 RTFNASITLDDMLNKDTK-DGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLNE 779
           RT+NASITL   L + T  D ++  KI+ Y  AN+ VAI+CNHQR+  K+ +  M  L  
Sbjct: 1   RTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQT 60

Query: 780 KLDELQAVLKELRTDLDRARXXXXXXXXXXXXXXXNLSSEALEKKISQTNAKIEKMQRDM 839
           K+D  +  L + R DL  A+                   E+ +K + +   ++ K++   
Sbjct: 61  KIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVV----ESKKKAVQRLEEQLMKLEVQA 116

Query: 840 KTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
             +E+ K +ALGTSK+NYLDPRITVAWCK+  VPIEKI+NK+   KF WA+D+ D D+ F
Sbjct: 117 TDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 176


>B3H4K2_ARATH (tr|B3H4K2) Uncharacterized protein At4g26701.1 OS=Arabidopsis
           thaliana GN=At4g26701 PE=4 SV=1
          Length = 69

 Score =  130 bits (327), Expect = 4e-28,   Method: Compositional matrix adjust.
 Identities = 59/68 (86%), Positives = 63/68 (92%)

Query: 831 KIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWAM 890
           KIEKM+RDM+TKEDLKTVALGTSKINY+DPRITVAWCKRHE PIEKIFNKSLL KF WAM
Sbjct: 2   KIEKMERDMQTKEDLKTVALGTSKINYMDPRITVAWCKRHEAPIEKIFNKSLLEKFAWAM 61

Query: 891 DVDPDFRF 898
           DV+P F F
Sbjct: 62  DVEPHFTF 69


>Q8WZG1_CRYNE (tr|Q8WZG1) Topoisomerase I (Fragment) OS=Cryptococcus neoformans
           GN=TOP1 PE=3 SV=1
          Length = 270

 Score =  127 bits (320), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 67/137 (48%), Positives = 89/137 (64%), Gaps = 1/137 (0%)

Query: 660 FLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTSKLNAHLKELMPGLTAK 718
           FLGKDS+++   VEV+  V+  I  F+ + KK GDD+FD L T+ LN HL  +MPGLTAK
Sbjct: 1   FLGKDSMRFHQEVEVDPQVFKNIKLFKAEPKKKGDDIFDRLTTTLLNKHLNTMMPGLTAK 60

Query: 719 VFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLN 778
           VFRT+NAS T  + L K  K+G V EKI  Y  AN+ VAI+CNHQ+SVSK  +    +  
Sbjct: 61  VFRTYNASWTFQEQLRKTPKNGTVAEKIAAYNTANRDVAILCNHQKSVSKGFEGSFAKAE 120

Query: 779 EKLDELQAVLKELRTDL 795
           +K+  L+    +LR  L
Sbjct: 121 DKIRALKYQRLKLRLQL 137


>Q8WZG9_CRYNE (tr|Q8WZG9) Topoisomerase I (Fragment) OS=Cryptococcus neoformans
           GN=TOP1 PE=3 SV=1
          Length = 270

 Score =  127 bits (320), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 67/137 (48%), Positives = 89/137 (64%), Gaps = 1/137 (0%)

Query: 660 FLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTSKLNAHLKELMPGLTAK 718
           FLGKDS+++   VEV+  V+  I  F+ + KK GDD+FD L T+ LN HL  +MPGLTAK
Sbjct: 1   FLGKDSMRFHQEVEVDPQVFKNIKLFKAEPKKKGDDIFDRLTTTLLNKHLNTMMPGLTAK 60

Query: 719 VFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLN 778
           VFRT+NAS T  + L K  K+G V EKI  Y  AN+ VAI+CNHQ+SVSK  +    +  
Sbjct: 61  VFRTYNASWTFQEQLKKTPKNGTVAEKIAAYNTANRDVAILCNHQKSVSKGFEGSFAKAE 120

Query: 779 EKLDELQAVLKELRTDL 795
           +K+  L+    +LR  L
Sbjct: 121 DKIRALKYQRLKLRLQL 137


>Q8X232_CRYNE (tr|Q8X232) Topoisomerase I (Fragment) OS=Cryptococcus neoformans
           GN=TOP1 PE=3 SV=1
          Length = 270

 Score =  127 bits (320), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 67/137 (48%), Positives = 89/137 (64%), Gaps = 1/137 (0%)

Query: 660 FLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTSKLNAHLKELMPGLTAK 718
           FLGKDS+++   VEV+  V+  I  F+ + KK GDD+FD L T+ LN HL  +MPGLTAK
Sbjct: 1   FLGKDSMRFHQEVEVDPQVFKNIKLFKAEPKKKGDDIFDRLTTTLLNKHLNTMMPGLTAK 60

Query: 719 VFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLN 778
           VFRT+NAS T  + L K  K+G V EKI  Y  AN+ VAI+CNHQ+SVSK  +    +  
Sbjct: 61  VFRTYNASWTFQEQLKKTPKNGTVAEKIAAYNTANRDVAILCNHQKSVSKGFEGSFAKAE 120

Query: 779 EKLDELQAVLKELRTDL 795
           +K+  L+    +LR  L
Sbjct: 121 DKIRALKYQRLKLRLQL 137


>Q8WZF2_CRYNE (tr|Q8WZF2) Topoisomerase I (Fragment) OS=Cryptococcus neoformans
           GN=TOP1 PE=3 SV=1
          Length = 270

 Score =  124 bits (312), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 66/137 (48%), Positives = 87/137 (63%), Gaps = 1/137 (0%)

Query: 660 FLGKDSIKYENTVEVELPVYNAILKFQKD-KKGGDDLFDMLDTSKLNAHLKELMPGLTAK 718
           FLGKDS+++   VEV+  V+  I  F+ D KK GDD+FD L T+ LN HL  +MPGLTAK
Sbjct: 1   FLGKDSMRFHQEVEVDPQVFKNIKLFKADPKKKGDDIFDRLTTTLLNKHLNGMMPGLTAK 60

Query: 719 VFRTFNASITLDDMLNKDTKDGDVGEKIVVYQHANKQVAIICNHQRSVSKSHDTQMTRLN 778
           VFRT+NAS T  + L     +G V EKI  Y  AN+ VAI+CNHQ+SVSK  +    +  
Sbjct: 61  VFRTYNASWTFQEQLKNTPTNGTVAEKIAAYNTANRDVAILCNHQKSVSKGFEGSFAKAE 120

Query: 779 EKLDELQAVLKELRTDL 795
           +K+  L+    +LR  L
Sbjct: 121 DKIRALKYQRLKLRLQL 137


>B4F8X8_MAIZE (tr|B4F8X8) Putative uncharacterized protein OS=Zea mays PE=4 SV=1
          Length = 84

 Score =  119 bits (297), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 57/82 (69%), Positives = 70/82 (85%)

Query: 653 PNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELM 712
           PN+++F+FLGKDSI+Y NTVEVE  VY AI  F+  KK G DLFD +DTS+LNAHLK+LM
Sbjct: 3   PNQIQFDFLGKDSIRYFNTVEVEELVYKAIEGFRAGKKPGQDLFDKIDTSRLNAHLKDLM 62

Query: 713 PGLTAKVFRTFNASITLDDMLN 734
           PGLTAKVFRT+NASITLD +++
Sbjct: 63  PGLTAKVFRTYNASITLDGIVS 84


>Q3TSR2_MOUSE (tr|Q3TSR2) Putative uncharacterized protein (Fragment) OS=Mus
           musculus GN=Top1 PE=2 SV=1
          Length = 144

 Score =  110 bits (276), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 60/148 (40%), Positives = 87/148 (58%), Gaps = 5/148 (3%)

Query: 752 ANKQVAIICNHQRSVSKSHDTQMTRLNEKLDELQAVLKELRTDLDRARXXXXXXXXXXXX 811
           AN+ VAI+CNHQR+  K+ +  M  L  K+D  +  L + R DL  A+            
Sbjct: 1   ANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTK 60

Query: 812 XXXNLSSEALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHE 871
                  E+ +K + +   ++ K++     +E+ K +ALGTSK+NYLDPRITVAWCK+  
Sbjct: 61  KVV----ESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWG 116

Query: 872 VPIEKIFNKSLLAKFTWAMDV-DPDFRF 898
           VPIEKI+NK+   KF WA+D+ D D+ F
Sbjct: 117 VPIEKIYNKTQREKFAWAIDMTDEDYEF 144


>B3MVN1_DROAN (tr|B3MVN1) GF23753 OS=Drosophila ananassae GN=GF23753 PE=4 SV=1
          Length = 240

 Score = 99.0 bits (245), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 65/211 (30%), Positives = 98/211 (46%), Gaps = 18/211 (8%)

Query: 354 KKWTTLVHNGVIFPPPYQ--PHRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKF 411
           +KWTTL HNG +F   YQ  P  V   Y+  P+ L    EE+AT+YA   ++   + D F
Sbjct: 17  QKWTTLSHNGPLFVDHYQALPKEVAFYYEDLPLKLNPTAEELATLYAKFMNSPLAITDTF 76

Query: 412 KENFWNDWRKLLGK--NHVIQNLKDCDFTPIYDWCXXXXXXXXXXXXXXXXXXXXXXXXX 469
            ENF+ D++  L +     I + + CDFT I  +                          
Sbjct: 77  NENFFKDFQSHLSRALRRQILSFELCDFTKIAFYI----------QGQQGVQRKLMTPMM 126

Query: 470 XXXXXWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDIVINIGKDAPIPE 529
                +  +DG + +V +F  + P L+R  G  PK G +K RI+P D+ IN  ++   P 
Sbjct: 127 RNHYGYCTIDGKRHRVPHFSFDGPSLYRRSG--PKYGMVKPRIQPEDVNIN-SQENGAPG 183

Query: 530 CPIPGERWKEIRHDNTVTWLAFWNDPINPKL 560
            P  G  WK + HD  V WL  W D ++ ++
Sbjct: 184 AP-DGHTWKSVIHDRRVDWLWSWTDALSGRV 213


>Q7YZP3_9TRYP (tr|Q7YZP3) Topoisomerase I subunit A (Fragment) OS=Leishmania
           panamensis GN=top1a PE=3 SV=1
          Length = 88

 Score = 98.2 bits (243), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 45/88 (51%), Positives = 64/88 (72%)

Query: 636 DTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDL 695
           DTVGCC+L+VE++   + N ++F+FLGKDSI+Y+N V V   VY  + +F + K  G D+
Sbjct: 1   DTVGCCSLRVEHIQLMSDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGTDI 60

Query: 696 FDMLDTSKLNAHLKELMPGLTAKVFRTF 723
           FD L+ ++LN HLK  M GL+AKVFRT+
Sbjct: 61  FDQLNPTQLNDHLKSFMNGLSAKVFRTY 88


>Q9NGZ9_LEIDO (tr|Q9NGZ9) Topoisomerase I (Fragment) OS=Leishmania donovani PE=3
           SV=1
          Length = 89

 Score = 92.8 bits (229), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 43/86 (50%), Positives = 61/86 (70%)

Query: 638 VGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFD 697
           VGCC+L+VE++     N ++F+FLGKDSI+Y+N V V   VY  + +F + K  G D+FD
Sbjct: 4   VGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDIFD 63

Query: 698 MLDTSKLNAHLKELMPGLTAKVFRTF 723
            L+ ++LN HLK  M GL+AKVFRT+
Sbjct: 64  QLNPTQLNDHLKSFMDGLSAKVFRTY 89


>Q6LBJ1_MOUSE (tr|Q6LBJ1) Topoisomerase I (Fragment) OS=Mus musculus GN=Top1 PE=2
           SV=1
          Length = 115

 Score = 86.3 bits (212), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 40/81 (49%), Positives = 58/81 (71%), Gaps = 1/81 (1%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF 878
           E+ +K + +   ++ K++     +E+ K +ALGTSK+NYLDPRITVAWCK+  VPIEKI+
Sbjct: 35  ESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIY 94

Query: 879 NKSLLAKFTWAMDV-DPDFRF 898
           NK+   KF WA+D+ D D+ F
Sbjct: 95  NKTQREKFAWAIDMTDEDYEF 115


>Q28GG2_XENTR (tr|Q28GG2) Novel protein similar to topoisomerase (DNA) I top1
           (Fragment) OS=Xenopus tropicalis GN=TEgg049i21.1-001
           PE=2 SV=1
          Length = 335

 Score = 83.2 bits (204), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 40/93 (43%), Positives = 56/93 (60%), Gaps = 4/93 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GKP+ L+   EEVA+ +A M D +Y  K+ F+
Sbjct: 226 KWKFLEHEGPVFAPPYEPLPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFR 285

Query: 413 ENFWNDWRK--LLGKNHVIQNLKDCDFTPIYDW 443
            N++ DWRK   L +  VI +L  CDFT ++ +
Sbjct: 286 NNYFMDWRKEMTLEERMVITDLAKCDFTEMFTY 318


>Q504F2_DANRE (tr|Q504F2) Top1l protein (Fragment) OS=Danio rerio GN=top1l PE=2
           SV=1
          Length = 321

 Score = 79.7 bits (195), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 38/93 (40%), Positives = 55/93 (59%), Gaps = 4/93 (4%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+ + EEVAT ++ M D +Y  KD F+
Sbjct: 209 KWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFR 268

Query: 413 ENFWNDWRKLLGKNH--VIQNLKDCDFTPIYDW 443
           +NF+ DWRK +       I +L  CDF+ + ++
Sbjct: 269 KNFFKDWRKEMTSEEKSKITDLNKCDFSNMSEY 301


>Q8TBP3_HUMAN (tr|Q8TBP3) TOP1MT protein (Fragment) OS=Homo sapiens GN=TOP1MT
           PE=2 SV=1
          Length = 101

 Score = 75.1 bits (183), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 39/86 (45%), Positives = 56/86 (65%), Gaps = 4/86 (4%)

Query: 817 SSEALEKK---ISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVP 873
           S   LEKK   + +   ++ ++      KE+ K VALGTSK+NYLDPRI++AWCKR  VP
Sbjct: 16  SRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVP 75

Query: 874 IEKIFNKSLLAKFTWAMDV-DPDFRF 898
           +EKI++K+   +F WA+ +   DF F
Sbjct: 76  VEKIYSKTQRERFAWALAMAGEDFEF 101


>Q38EP5_9TRYP (tr|Q38EP5) DNA topoisomerase type IB small subunit OS=Trypanosoma
           brucei GN=Tb09.160.5070 PE=4 SV=1
          Length = 273

 Score = 73.2 bits (178), Expect = 9e-11,   Method: Compositional matrix adjust.
 Identities = 32/78 (41%), Positives = 52/78 (66%), Gaps = 1/78 (1%)

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           +E +I +   +++ ++  +K K+D KTV+LGTSK+NY+DPRI  +W   + VPI ++F+ 
Sbjct: 197 IEAEIGKHEKRLKDVENMLKMKQDNKTVSLGTSKVNYIDPRIVCSWANENNVPISRLFSA 256

Query: 881 SLLAKFTWAMDVDPDFRF 898
           +L  KF WA+    DF F
Sbjct: 257 TLQKKFPWALKAR-DFTF 273


>Q7Z011_9TRYP (tr|Q7Z011) Type IB DNA topoisomerase small subunit OS=Trypanosoma
           brucei PE=2 SV=1
          Length = 273

 Score = 73.2 bits (178), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 32/78 (41%), Positives = 52/78 (66%), Gaps = 1/78 (1%)

Query: 821 LEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 880
           +E +I +   +++ ++  +K K+D KTV+LGTSK+NY+DPRI  +W   + VPI ++F+ 
Sbjct: 197 IEAEIGKHEKRLKDVENMLKMKQDNKTVSLGTSKVNYIDPRIVCSWANENNVPISRLFSA 256

Query: 881 SLLAKFTWAMDVDPDFRF 898
           +L  KF WA+    DF F
Sbjct: 257 TLQKKFPWALKAR-DFTF 273


>Q70HS8_9TRYP (tr|Q70HS8) DNA topoisomerase I subunit B (Fragment) OS=Leishmania
           panamensis GN=top1b PE=4 SV=1
          Length = 269

 Score = 72.8 bits (177), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 50/69 (72%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSKINY+DPRI  +W K  +VPI K+F+ ++L KF WA
Sbjct: 202 ERLNREENVIRIKDDNKAVSLGTSKINYIDPRIVCSWAKAQDVPISKVFSATILKKFPWA 261

Query: 890 MDVDPDFRF 898
           M+ + +F F
Sbjct: 262 MNAE-NFDF 269


>A4H3S7_LEIBR (tr|A4H3S7) DNA topoisomerase type IB small subunit OS=Leishmania
           braziliensis GN=LbrM04_V2.0110 PE=4 SV=1
          Length = 269

 Score = 72.4 bits (176), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 49/69 (71%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSKINY+DPRI  +W K  +VPI K+F+ ++L KF WA
Sbjct: 202 ERLNREENVIRIKDDNKAVSLGTSKINYIDPRIVCSWAKAQDVPISKVFSATILKKFPWA 261

Query: 890 MDVDPDFRF 898
           M  + +F F
Sbjct: 262 MSAE-NFDF 269


>Q5RL92_TRYCR (tr|Q5RL92) Type IB topoisomerase small subunit OS=Trypanosoma
           cruzi PE=4 SV=1
          Length = 271

 Score = 71.6 bits (174), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 48/69 (69%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSK+NY+DPRI  +W K + VPI KIF+ +L  KF WA
Sbjct: 204 ERLNREENMIRIKDDNKAVSLGTSKVNYIDPRIVCSWAKEYNVPIGKIFSATLQKKFPWA 263

Query: 890 MDVDPDFRF 898
           M  + +F F
Sbjct: 264 MGAE-NFSF 271


>Q4DUD0_TRYCR (tr|Q4DUD0) DNA topoisomerase type IB small subunit, putative
           OS=Trypanosoma cruzi GN=Tc00.1047053506625.110 PE=4 SV=1
          Length = 272

 Score = 71.2 bits (173), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 48/69 (69%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSK+NY+DPRI  +W K + VPI KIF+ +L  KF WA
Sbjct: 205 ERLNREENMIRIKDDNKAVSLGTSKVNYIDPRIVCSWAKEYNVPIGKIFSATLQKKFPWA 264

Query: 890 MDVDPDFRF 898
           M  + +F F
Sbjct: 265 MGAE-NFSF 272


>Q3ULF5_MOUSE (tr|Q3ULF5) Putative uncharacterized protein (Fragment) OS=Mus
           musculus GN=Top1 PE=2 SV=1
          Length = 291

 Score = 71.2 bits (173), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 33/71 (46%), Positives = 44/71 (61%), Gaps = 2/71 (2%)

Query: 355 KWTTLVHNGVIFPPPYQP--HRVKMLYKGKPVDLTADQEEVATMYAVMRDTDYMLKDKFK 412
           KW  L H G +F PPY+P    VK  Y GK + L+   EEVAT +A M D +Y  K+ F+
Sbjct: 218 KWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFR 277

Query: 413 ENFWNDWRKLL 423
           +NF+ DWRK +
Sbjct: 278 KNFFKDWRKEM 288


>Q95Z89_LEIMA (tr|Q95Z89) Possible DNA topoisomerase I-related protein
           OS=Leishmania major GN=LT.06 PE=4 SV=1
          Length = 262

 Score = 70.9 bits (172), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 49/69 (71%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSKINY+DPRI  +W K  +VPI KIF+ ++  KF WA
Sbjct: 195 ERLNREENIIRIKDDNKAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWA 254

Query: 890 MDVDPDFRF 898
           M+ + +F F
Sbjct: 255 MNAE-NFDF 262


>Q8WQM6_LEIDO (tr|Q8WQM6) DNA topoisomerase I-like protein (Small subunit of
           topoisomerase IB TOP1S) OS=Leishmania donovani PE=1 SV=1
          Length = 262

 Score = 70.9 bits (172), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 49/69 (71%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSKINY+DPRI  +W K  +VPI KIF+ ++  KF WA
Sbjct: 195 ERLNREENIIRIKDDNKAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWA 254

Query: 890 MDVDPDFRF 898
           M+ + +F F
Sbjct: 255 MNAE-NFDF 262


>A4HS02_LEIIN (tr|A4HS02) DNA topoisomerase type IB small subunit OS=Leishmania
           infantum GN=LinJ04.0070 PE=4 SV=1
          Length = 262

 Score = 70.9 bits (172), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 49/69 (71%), Gaps = 4/69 (5%)

Query: 833 EKMQRD---MKTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFTWA 889
           E++ R+   ++ K+D K V+LGTSKINY+DPRI  +W K  +VPI KIF+ ++  KF WA
Sbjct: 195 ERLNREENIIRIKDDNKAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWA 254

Query: 890 MDVDPDFRF 898
           M+ + +F F
Sbjct: 255 MNAE-NFDF 262


>Q46T09_RALEJ (tr|Q46T09) Putative uncharacterized protein OS=Ralstonia eutropha
           (strain JMP134) GN=Reut_B4373 PE=4 SV=1
          Length = 372

 Score = 55.5 bits (132), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 46/170 (27%), Positives = 80/170 (47%), Gaps = 15/170 (8%)

Query: 577 DKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATY-LIDKLALRAGNEKDDDEA 635
           D +KY +       +  +RA   +D     + ++++A A   L+D   +R G  +   + 
Sbjct: 126 DTDKYGRLAQFGTILPRLRARVERDLARNGMPREKVAAAVVRLLDATLVRVGTPRYARQN 185

Query: 636 DTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDL 695
            T G  TL+  +VT    ++L+F F GK  I ++  V V  P    +++   D   G  L
Sbjct: 186 RTYGLTTLRPRHVTVRG-SRLRFQFTGKSGITHD--VSVNDPRVARVVRNCADLP-GQCL 241

Query: 696 FDMLD---------TSKLNAHLKELMPG-LTAKVFRTFNASITLDDMLNK 735
           F  +D         ++ +NA+L+E+  G  TAK FRT+  S+    +L K
Sbjct: 242 FKYVDSDGQVRDIGSTDVNAYLREVTGGEFTAKDFRTWAGSVHALALLRK 291


>Q2HPH0_BOVIN (tr|Q2HPH0) Topoisomerase I (Fragment) OS=Bos taurus PE=2 SV=1
          Length = 67

 Score = 54.3 bits (129), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 24/51 (47%), Positives = 37/51 (72%)

Query: 819 EALEKKISQTNAKIEKMQRDMKTKEDLKTVALGTSKINYLDPRITVAWCKR 869
           E+ +K + +   ++ K++     +E+ K +ALGTSK+NYLDPRITVAWCK+
Sbjct: 15  ESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKK 65


>Q6MBZ3_PARUW (tr|Q6MBZ3) Putative DNA topoisomerase I OS=Protochlamydia
           amoebophila (strain UWE25) GN=topI PE=4 SV=1
          Length = 358

 Score = 52.8 bits (125), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 45/163 (27%), Positives = 82/163 (50%), Gaps = 15/163 (9%)

Query: 576 SDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQI-AVATYLIDKLALRAGNEKDDDE 634
           SD+ KY K       +  IR    +D +  +++K++I AV  YL++   +R GNE    E
Sbjct: 108 SDETKYGKMIAFAQALPTIRKRIKRDLSLTEMSKEKILAVVVYLLEMTLIRVGNEAYAKE 167

Query: 635 ADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDD 694
            ++ G  TL+  +V+ E   ++ F F+GK     ++T+ +       I+K  KD   G +
Sbjct: 168 NNSFGLTTLQNHHVSIEG-TEMTFKFIGKSG--KQHTITLYDKRLAKIVKRCKDLP-GQE 223

Query: 695 LFDMLD---------TSKLNAHLKELM-PGLTAKVFRTFNASI 727
           LF+ +D         ++ +N +L+ +     TAK FRT+  ++
Sbjct: 224 LFEYMDENAMPVSISSTNVNEYLRMITNDHFTAKDFRTWAGTV 266


>Q0KBJ9_RALEH (tr|Q0KBJ9) DNA Topoisomerase IB OS=Ralstonia eutropha (strain ATCC
           17699 / H16 / DSM 428 / Stanier 337) GN=H16_A1489 PE=4
           SV=1
          Length = 329

 Score = 52.8 bits (125), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 48/186 (25%), Positives = 83/186 (44%), Gaps = 15/186 (8%)

Query: 574 GQSDKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQIAVATY-LIDKLALRAGNEKDD 632
            Q D +KY +       +  +RA   +D     + ++++  A   L+D   +R G+ +  
Sbjct: 82  AQRDSDKYARLPAFGSVLPRLRARVARDLRRNGMPREKVVAAVVQLLDATLVRVGSPQYA 141

Query: 633 DEADTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGG 692
            +  T G  TL+  +VT    ++L+F F GK  I ++  V V  P    I++   D   G
Sbjct: 142 RQNRTYGLTTLRRRHVTVRG-SRLRFQFTGKSGITHD--VSVNDPRLARIVRNCADLP-G 197

Query: 693 DDLFDMLD---------TSKLNAHLKELMPG-LTAKVFRTFNASITLDDMLNKDTKDGDV 742
             LF   D         ++ +NA+L++   G  TAK FRT+  S+    +L     DG+ 
Sbjct: 198 QCLFKYRDSDGEIREVGSADVNAYLQQATGGDFTAKDFRTWAGSVHALALLRAAGADGEA 257

Query: 743 GEKIVV 748
             +  V
Sbjct: 258 ARRKCV 263


>B2JMY2_BURP8 (tr|B2JMY2) DNA topoisomerase OS=Burkholderia phymatum (strain DSM
           17167 / STM815) GN=Bphy_5297 PE=3 SV=1
          Length = 411

 Score = 50.8 bits (120), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 43/162 (26%), Positives = 80/162 (49%), Gaps = 15/162 (9%)

Query: 577 DKEKYEKARMLKDYIGNIRAAYTKDFTSKDITKQQ-IAVATYLIDKLALRAGNEKDDDEA 635
           D +K+ +       +  IRA   +D   K + +++ IA   +L+D   +R G+ +   + 
Sbjct: 112 DADKFGRMAAFGQALPKIRARVARDLARKGMPREKVIAAVVHLLDTTLIRIGSVEYARDN 171

Query: 636 DTVGCCTLKVENVTREAPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDL 695
            + G  TL+ ++VT  A  +++F F GK  I  E+ V V+ P    I++   D   G +L
Sbjct: 172 QSYGLTTLRKKHVTIRA-GEVRFRFAGKSGI--EHDVTVDNPRVKRIVRQCADLP-GHEL 227

Query: 696 FDMLD---------TSKLNAHLKELMPG-LTAKVFRTFNASI 727
           F  +D         ++ +N +L+E+     TAK +RT+  S+
Sbjct: 228 FQYVDEDGARHTIGSADINDYLREVSHADFTAKDYRTWAGSV 269


>Q85387_VARV (tr|Q85387) Homolog of vaccinia virus CDS H6R OS=Variola major
           virus GN=I6R PE=3 SV=1
          Length = 314

 Score = 50.1 bits (118), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 39/134 (29%), Positives = 64/134 (47%), Gaps = 9/134 (6%)

Query: 602 FTSKDITKQ------QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNK 655
           F +K+I K       Q+AV   +     +R G  K   E +TVG  TLK +++   +P+K
Sbjct: 101 FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHI-EISPDK 159

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           +   F+GKD + +E  V     +Y  +LK   D    + LF+ L   K+   +K+   G+
Sbjct: 160 IVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYECIKQF--GI 217

Query: 716 TAKVFRTFNASITL 729
             K  RT+  + T 
Sbjct: 218 RIKDLRTYGVNYTF 231


>Q0N557_VARV (tr|Q0N557) Topoisomerase type IB OS=Variola virus
           GN=VARV_AFG70_vlt4_093 PE=3 SV=1
          Length = 314

 Score = 50.1 bits (118), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 39/134 (29%), Positives = 64/134 (47%), Gaps = 9/134 (6%)

Query: 602 FTSKDITKQ------QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNK 655
           F +K+I K       Q+AV   +     +R G  K   E +TVG  TLK +++   +P+K
Sbjct: 101 FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHI-EISPDK 159

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           +   F+GKD + +E  V     +Y  +LK   D    + LF+ L   K+   +K+   G+
Sbjct: 160 IVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYECIKQF--GI 217

Query: 716 TAKVFRTFNASITL 729
             K  RT+  + T 
Sbjct: 218 RIKDLRTYGVNYTF 231


>Q0NEE3_VARV (tr|Q0NEE3) Topoisomerase type IB OS=Variola virus
           GN=VARV_KOR47_lee_093 PE=3 SV=1
          Length = 314

 Score = 49.7 bits (117), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 39/134 (29%), Positives = 64/134 (47%), Gaps = 9/134 (6%)

Query: 602 FTSKDITKQ------QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVTREAPNK 655
           F +K+I K       Q+AV   +     +R G  K   E +TVG  TLK +++   +P+K
Sbjct: 101 FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHI-EISPDK 159

Query: 656 LKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKKGGDDLFDMLDTSKLNAHLKELMPGL 715
           +   F+GKD + +E  V     +Y  +LK   D    + LF+ L   K+   +K+   G+
Sbjct: 160 IVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYECIKQF--GI 217

Query: 716 TAKVFRTFNASITL 729
             K  RT+  + T 
Sbjct: 218 RIKDLRTYGVNYTF 231