Miyakogusa Predicted Gene
- Lj6g3v2221990.1
BLASTP 2.2.25 [Feb-01-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= Lj6g3v2221990.1 tr|I3S0L6|I3S0L6_LOTJA Methylenetetrahydrofolate
reductase OS=Lotus japonicus PE=2
SV=1,99.69,0,METHYLENETETRAHYDROFOLATE REDUCTASE,NULL;
METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE
RELA,CUFF.60905.1
(323 letters)
Database: trembl
41,451,118 sequences; 13,208,986,710 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
I3S0L6_LOTJA (tr|I3S0L6) Methylenetetrahydrofolate reductase OS=... 668 0.0
I1JZE1_SOYBN (tr|I1JZE1) Methylenetetrahydrofolate reductase OS=... 592 e-167
I1JZE2_SOYBN (tr|I1JZE2) Methylenetetrahydrofolate reductase OS=... 592 e-167
I1KG02_SOYBN (tr|I1KG02) Methylenetetrahydrofolate reductase OS=... 590 e-166
I1KG04_SOYBN (tr|I1KG04) Methylenetetrahydrofolate reductase OS=... 590 e-166
I1KG03_SOYBN (tr|I1KG03) Methylenetetrahydrofolate reductase OS=... 588 e-166
C6T731_SOYBN (tr|C6T731) Methylenetetrahydrofolate reductase OS=... 577 e-162
B9HG95_POPTR (tr|B9HG95) Methylenetetrahydrofolate reductase OS=... 576 e-162
M5W952_PRUPE (tr|M5W952) Uncharacterized protein OS=Prunus persi... 572 e-161
J7EQB2_TOBAC (tr|J7EQB2) Methylenetetrahydrofolate reductase OS=... 572 e-161
J7EPI5_NICTO (tr|J7EPI5) Methylenetetrahydrofolate reductase OS=... 572 e-161
J7EQ04_NICSY (tr|J7EQ04) Methylenetetrahydrofolate reductase OS=... 570 e-160
J7EPU9_TOBAC (tr|J7EPU9) Methylenetetrahydrofolate reductase OS=... 570 e-160
M1BBU4_SOLTU (tr|M1BBU4) Methylenetetrahydrofolate reductase OS=... 568 e-159
J7EQB1_NICTO (tr|J7EQB1) Methylenetetrahydrofolate reductase OS=... 568 e-159
J7EPV1_NICTO (tr|J7EPV1) Methylenetetrahydrofolate reductase OS=... 566 e-159
K4D5E7_SOLLC (tr|K4D5E7) Methylenetetrahydrofolate reductase OS=... 563 e-158
B9N8L0_POPTR (tr|B9N8L0) Methylenetetrahydrofolate reductase OS=... 562 e-158
B9STA4_RICCO (tr|B9STA4) Methylenetetrahydrofolate reductase OS=... 560 e-157
K4C2P8_SOLLC (tr|K4C2P8) Methylenetetrahydrofolate reductase OS=... 559 e-157
R0HRY0_9BRAS (tr|R0HRY0) Uncharacterized protein OS=Capsella rub... 558 e-157
Q10BJ7_ORYSJ (tr|Q10BJ7) Methylenetetrahydrofolate reductase OS=... 558 e-157
A2XNC0_ORYSI (tr|A2XNC0) Methylenetetrahydrofolate reductase OS=... 558 e-157
F6I5I7_VITVI (tr|F6I5I7) Methylenetetrahydrofolate reductase OS=... 558 e-156
A5ATB7_VITVI (tr|A5ATB7) Methylenetetrahydrofolate reductase OS=... 558 e-156
M1C552_SOLTU (tr|M1C552) Methylenetetrahydrofolate reductase OS=... 557 e-156
Q10BJ6_ORYSJ (tr|Q10BJ6) Methylenetetrahydrofolate reductase OS=... 557 e-156
D7LKW5_ARALL (tr|D7LKW5) Methylenetetrahydrofolate reductase OS=... 557 e-156
M1C551_SOLTU (tr|M1C551) Methylenetetrahydrofolate reductase OS=... 555 e-156
K4AMY6_SETIT (tr|K4AMY6) Methylenetetrahydrofolate reductase OS=... 550 e-154
M0TJL5_MUSAM (tr|M0TJL5) Methylenetetrahydrofolate reductase OS=... 548 e-154
C5WVY7_SORBI (tr|C5WVY7) Methylenetetrahydrofolate reductase OS=... 548 e-153
M4CGR4_BRARP (tr|M4CGR4) Methylenetetrahydrofolate reductase OS=... 547 e-153
N1QRS8_AEGTA (tr|N1QRS8) Putative methylenetetrahydrofolate redu... 546 e-153
I1GLP9_BRADI (tr|I1GLP9) Methylenetetrahydrofolate reductase OS=... 546 e-153
M4F9A1_BRARP (tr|M4F9A1) Methylenetetrahydrofolate reductase OS=... 545 e-153
J3LU35_ORYBR (tr|J3LU35) Methylenetetrahydrofolate reductase OS=... 545 e-152
D7LWJ5_ARALL (tr|D7LWJ5) Methylenetetrahydrofolate reductase OS=... 544 e-152
R0FNP9_9BRAS (tr|R0FNP9) Uncharacterized protein OS=Capsella rub... 543 e-152
B8LKP0_PICSI (tr|B8LKP0) Methylenetetrahydrofolate reductase OS=... 543 e-152
M4CTF4_BRARP (tr|M4CTF4) Methylenetetrahydrofolate reductase OS=... 542 e-152
G3C900_PINPS (tr|G3C900) Methylenetetrahydrofolate reductase OS=... 540 e-151
F4JAK1_ARATH (tr|F4JAK1) Methylenetetrahydrofolate reductase OS=... 538 e-151
M7ZYT1_TRIUA (tr|M7ZYT1) Putative methylenetetrahydrofolate redu... 527 e-147
M4CKS5_BRARP (tr|M4CKS5) Methylenetetrahydrofolate reductase OS=... 518 e-144
A9U4S7_PHYPA (tr|A9U4S7) Methylenetetrahydrofolate reductase OS=... 510 e-142
M0YZ59_HORVD (tr|M0YZ59) Methylenetetrahydrofolate reductase OS=... 506 e-141
A6XMY8_TRIMO (tr|A6XMY8) Methylenetetrahydrofolate reductase OS=... 505 e-140
A9RW65_PHYPA (tr|A9RW65) Methylenetetrahydrofolate reductase OS=... 501 e-140
D8QNN7_SELML (tr|D8QNN7) Methylenetetrahydrofolate reductase OS=... 498 e-139
D8RDX1_SELML (tr|D8RDX1) Methylenetetrahydrofolate reductase OS=... 498 e-138
M0RR35_MUSAM (tr|M0RR35) Methylenetetrahydrofolate reductase OS=... 496 e-138
M1C550_SOLTU (tr|M1C550) Methylenetetrahydrofolate reductase OS=... 464 e-128
I0YN51_9CHLO (tr|I0YN51) Methylenetetrahydrofolate reductase OS=... 433 e-119
D8U7H4_VOLCA (tr|D8U7H4) Methylenetetrahydrofolate reductase OS=... 431 e-118
D8S976_SELML (tr|D8S976) Methylenetetrahydrofolate reductase OS=... 418 e-114
D8SVM0_SELML (tr|D8SVM0) Methylenetetrahydrofolate reductase OS=... 414 e-113
A8IAY6_CHLRE (tr|A8IAY6) Methylenetetrahydrofolate reductase OS=... 405 e-111
J7MPV6_9CHLO (tr|J7MPV6) Methylenetetrahydrofolate reductase OS=... 385 e-105
E1Z340_CHLVA (tr|E1Z340) Methylenetetrahydrofolate reductase OS=... 379 e-103
L8H1T6_ACACA (tr|L8H1T6) Methylenetetrahydrofolate reductase OS=... 373 e-101
L1IVS6_GUITH (tr|L1IVS6) Methylenetetrahydrofolate reductase OS=... 372 e-101
F0ZME6_DICPU (tr|F0ZME6) Methylenetetrahydrofolate reductase OS=... 363 5e-98
D3BTZ2_POLPA (tr|D3BTZ2) Methylenetetrahydrofolate reductase OS=... 362 1e-97
K3WKM9_PYTUL (tr|K3WKM9) Methylenetetrahydrofolate reductase OS=... 360 4e-97
D2V2R1_NAEGR (tr|D2V2R1) Methylenetetrahydrofolate reductase OS=... 357 3e-96
Q54X84_DICDI (tr|Q54X84) Methylenetetrahydrofolate reductase OS=... 355 2e-95
R7Q356_CHOCR (tr|R7Q356) Methylenetetrahydrofolate reductase OS=... 352 7e-95
F4PLP1_DICFS (tr|F4PLP1) Methylenetetrahydrofolate reductase OS=... 349 6e-94
M2XB69_GALSU (tr|M2XB69) Methylenetetrahydrofolate reductase OS=... 347 5e-93
D0N474_PHYIT (tr|D0N474) Methylenetetrahydrofolate reductase OS=... 337 3e-90
M1UY35_CYAME (tr|M1UY35) Methylenetetrahydrofolate reductase OS=... 336 6e-90
G4YYD3_PHYSP (tr|G4YYD3) Methylenetetrahydrofolate reductase OS=... 336 6e-90
H3GAC2_PHYRM (tr|H3GAC2) Methylenetetrahydrofolate reductase OS=... 334 3e-89
F4P4P0_BATDJ (tr|F4P4P0) Methylenetetrahydrofolate reductase OS=... 333 6e-89
D8LCN9_ECTSI (tr|D8LCN9) Methylenetetrahydrofolate reductase OS=... 327 4e-87
I1BPZ7_RHIO9 (tr|I1BPZ7) Methylenetetrahydrofolate reductase OS=... 322 2e-85
F0W2Q3_9STRA (tr|F0W2Q3) Methylenetetrahydrofolate reductase OS=... 319 9e-85
J9J1L8_9SPIT (tr|J9J1L8) Methylenetetrahydrofolate reductase OS=... 315 2e-83
J4GI53_FIBRA (tr|J4GI53) Methylenetetrahydrofolate reductase OS=... 314 3e-83
A8N945_COPC7 (tr|A8N945) Methylenetetrahydrofolate reductase OS=... 313 4e-83
C5E2N6_LACTC (tr|C5E2N6) Methylenetetrahydrofolate reductase OS=... 313 5e-83
K5WIH4_PHACS (tr|K5WIH4) Methylenetetrahydrofolate reductase OS=... 312 9e-83
C5FFF6_ARTOC (tr|C5FFF6) Methylenetetrahydrofolate reductase OS=... 311 1e-82
D4AYQ9_ARTBC (tr|D4AYQ9) Methylenetetrahydrofolate reductase OS=... 311 2e-82
F2S694_TRIT1 (tr|F2S694) Methylenetetrahydrofolate reductase OS=... 311 2e-82
D4DJK8_TRIVH (tr|D4DJK8) Methylenetetrahydrofolate reductase OS=... 311 2e-82
D8Q1D9_SCHCM (tr|D8Q1D9) Methylenetetrahydrofolate reductase OS=... 311 3e-82
C4JG55_UNCRE (tr|C4JG55) Methylenetetrahydrofolate reductase OS=... 310 3e-82
F2SQ86_TRIRC (tr|F2SQ86) Methylenetetrahydrofolate reductase OS=... 310 3e-82
L8X3I0_9HOMO (tr|L8X3I0) Methylenetetrahydrofolate reductase OS=... 309 9e-82
F2TKH4_AJEDA (tr|F2TKH4) Methylenetetrahydrofolate reductase OS=... 309 1e-81
C5GPB7_AJEDR (tr|C5GPB7) Methylenetetrahydrofolate reductase OS=... 309 1e-81
C5JE18_AJEDS (tr|C5JE18) Methylenetetrahydrofolate reductase OS=... 308 1e-81
F2PWP0_TRIEC (tr|F2PWP0) Methylenetetrahydrofolate reductase OS=... 308 1e-81
Q6FU20_CANGA (tr|Q6FU20) Methylenetetrahydrofolate reductase OS=... 308 2e-81
F8Q5A5_SERL3 (tr|F8Q5A5) Methylenetetrahydrofolate reductase OS=... 308 2e-81
I4YIV3_WALSC (tr|I4YIV3) Methylenetetrahydrofolate reductase OS=... 308 2e-81
J8Q880_SACAR (tr|J8Q880) Methylenetetrahydrofolate reductase OS=... 307 3e-81
A1C6H3_ASPCL (tr|A1C6H3) Methylenetetrahydrofolate reductase OS=... 307 3e-81
B8BVS6_THAPS (tr|B8BVS6) Methylenetetrahydrofolate reductase OS=... 306 6e-81
M5G436_DACSP (tr|M5G436) Methylenetetrahydrofolate reduct OS=Dac... 306 7e-81
M2R3N4_CERSU (tr|M2R3N4) Methylenetetrahydrofolate reductase OS=... 306 7e-81
E6ZP86_SPORE (tr|E6ZP86) Methylenetetrahydrofolate reductase OS=... 306 9e-81
G4TUD6_PIRID (tr|G4TUD6) Methylenetetrahydrofolate reductase OS=... 305 1e-80
J3K5S4_COCIM (tr|J3K5S4) Methylenetetrahydrofolate reductase OS=... 305 1e-80
E9DEV7_COCPS (tr|E9DEV7) Methylenetetrahydrofolate reductase OS=... 305 1e-80
C5PJM0_COCP7 (tr|C5PJM0) Methylenetetrahydrofolate reductase OS=... 305 1e-80
M9MW94_ASHGS (tr|M9MW94) FAAR170Wp OS=Ashbya gossypii FDAG1 GN=F... 305 2e-80
R9P122_9BASI (tr|R9P122) Methylenetetrahydrofolate reductase OS=... 305 2e-80
D8LT26_ECTSI (tr|D8LT26) Methylenetetrahydrofolate reductase OS=... 305 2e-80
M9M1W1_9BASI (tr|M9M1W1) 5,10-methylenetetrahydrofolate reductas... 304 2e-80
A9UZU5_MONBE (tr|A9UZU5) Methylenetetrahydrofolate reductase OS=... 304 3e-80
B0CU22_LACBS (tr|B0CU22) Methylenetetrahydrofolate reductase OS=... 304 3e-80
E0XYM8_9CHLR (tr|E0XYM8) Methylenetetrahydrofolate reductase OS=... 303 5e-80
H2ANE8_KAZAF (tr|H2ANE8) Methylenetetrahydrofolate reductase OS=... 303 5e-80
F0U6Q8_AJEC8 (tr|F0U6Q8) Methylenetetrahydrofolate reductase OS=... 303 5e-80
C0NNE8_AJECG (tr|C0NNE8) Methylenetetrahydrofolate reductase OS=... 303 5e-80
C5E412_ZYGRC (tr|C5E412) Methylenetetrahydrofolate reductase OS=... 303 7e-80
Q75EA7_ASHGO (tr|Q75EA7) Methylenetetrahydrofolate reductase OS=... 302 9e-80
J4TZ22_SACK1 (tr|J4TZ22) Methylenetetrahydrofolate reductase OS=... 302 1e-79
K0TG67_THAOC (tr|K0TG67) Methylenetetrahydrofolate reductase OS=... 302 1e-79
Q4P5K1_USTMA (tr|Q4P5K1) Methylenetetrahydrofolate reductase OS=... 302 1e-79
H0GUP5_9SACH (tr|H0GUP5) Methylenetetrahydrofolate reductase OS=... 301 1e-79
C1GYS1_PARBA (tr|C1GYS1) Methylenetetrahydrofolate reductase OS=... 301 2e-79
F0XZS1_AURAN (tr|F0XZS1) Methylenetetrahydrofolate reductase OS=... 301 2e-79
J3Q094_PUCT1 (tr|J3Q094) Methylenetetrahydrofolate reductase OS=... 301 2e-79
G3Y2A7_ASPNA (tr|G3Y2A7) Methylenetetrahydrofolate reductase OS=... 301 3e-79
A2QCE3_ASPNC (tr|A2QCE3) Methylenetetrahydrofolate reductase OS=... 301 3e-79
A1DH45_NEOFI (tr|A1DH45) Methylenetetrahydrofolate reductase OS=... 300 3e-79
Q2UEQ8_ASPOR (tr|Q2UEQ8) Methylenetetrahydrofolate reductase OS=... 300 3e-79
I8TUJ4_ASPO3 (tr|I8TUJ4) Methylenetetrahydrofolate reductase OS=... 300 3e-79
B8NG74_ASPFN (tr|B8NG74) Methylenetetrahydrofolate reductase OS=... 300 3e-79
G0WG35_NAUDC (tr|G0WG35) Methylenetetrahydrofolate reductase OS=... 300 3e-79
Q5B0P7_EMENI (tr|Q5B0P7) Methylenetetrahydrofolate reductase OS=... 300 4e-79
Q0GA67_EMEND (tr|Q0GA67) Methylenetetrahydrofolate reductase OS=... 300 4e-79
G7X5I8_ASPKW (tr|G7X5I8) Methylenetetrahydrofolate reductase OS=... 300 4e-79
I2FMK6_USTH4 (tr|I2FMK6) Methylenetetrahydrofolate reductase OS=... 300 7e-79
C1G7L7_PARBD (tr|C1G7L7) Methylenetetrahydrofolate reductase OS=... 299 8e-79
B0XSG0_ASPFC (tr|B0XSG0) Methylenetetrahydrofolate reductase OS=... 299 9e-79
C0RZ73_PARBP (tr|C0RZ73) Methylenetetrahydrofolate reductase OS=... 299 9e-79
Q0CXY7_ASPTN (tr|Q0CXY7) Methylenetetrahydrofolate reductase OS=... 299 1e-78
I1CMT8_RHIO9 (tr|I1CMT8) Methylenetetrahydrofolate reductase OS=... 298 1e-78
G7IDE3_MEDTR (tr|G7IDE3) Methylenetetrahydrofolate reductase OS=... 298 1e-78
B6H6J4_PENCW (tr|B6H6J4) Methylenetetrahydrofolate reductase OS=... 298 2e-78
C8Z8C5_YEAS8 (tr|C8Z8C5) Methylenetetrahydrofolate reductase OS=... 298 2e-78
N1P5B8_YEASX (tr|N1P5B8) Met13p OS=Saccharomyces cerevisiae CEN.... 298 2e-78
C7GX60_YEAS2 (tr|C7GX60) Methylenetetrahydrofolate reductase OS=... 298 2e-78
A6ZU57_YEAS7 (tr|A6ZU57) Methylenetetrahydrofolate reductase OS=... 298 2e-78
Q4X140_ASPFU (tr|Q4X140) Methylenetetrahydrofolate reductase OS=... 298 2e-78
E7QEM0_YEASZ (tr|E7QEM0) Methylenetetrahydrofolate reductase OS=... 298 3e-78
E7NHJ8_YEASO (tr|E7NHJ8) Methylenetetrahydrofolate reductase OS=... 298 3e-78
H0GFV1_9SACH (tr|H0GFV1) Methylenetetrahydrofolate reductase OS=... 297 3e-78
E7KCE7_YEASA (tr|E7KCE7) Methylenetetrahydrofolate reductase OS=... 297 3e-78
B3LHI5_YEAS1 (tr|B3LHI5) Methylenetetrahydrofolate reductase OS=... 297 3e-78
E7LU98_YEASV (tr|E7LU98) Methylenetetrahydrofolate reductase OS=... 297 3e-78
E7Q3R8_YEASB (tr|E7Q3R8) Methylenetetrahydrofolate reductase OS=... 297 3e-78
E3JWM7_PUCGT (tr|E3JWM7) Methylenetetrahydrofolate reductase OS=... 296 5e-78
K9H2D3_PEND1 (tr|K9H2D3) Methylenetetrahydrofolate reductase OS=... 296 6e-78
K9GDB8_PEND2 (tr|K9GDB8) Methylenetetrahydrofolate reductase OS=... 296 6e-78
G2WDX7_YEASK (tr|G2WDX7) Methylenetetrahydrofolate reductase OS=... 296 8e-78
G0VEA4_NAUCC (tr|G0VEA4) Methylenetetrahydrofolate reductase OS=... 296 8e-78
Q6CG63_YARLI (tr|Q6CG63) Methylenetetrahydrofolate reductase OS=... 296 9e-78
J7R7R4_KAZNA (tr|J7R7R4) Methylenetetrahydrofolate reductase OS=... 295 1e-77
F4RGV4_MELLP (tr|F4RGV4) Methylenetetrahydrofolate reductase OS=... 295 1e-77
R9AFX7_WALIC (tr|R9AFX7) Methylenetetrahydrofolate reductase 2 O... 295 2e-77
A4HQF9_LEIBR (tr|A4HQF9) Methylenetetrahydrofolate reductase OS=... 294 2e-77
E3KZT2_PUCGT (tr|E3KZT2) Methylenetetrahydrofolate reductase OS=... 293 6e-77
K0KJW6_WICCF (tr|K0KJW6) Methylenetetrahydrofolate reductase OS=... 292 1e-76
I1CGQ8_RHIO9 (tr|I1CGQ8) Methylenetetrahydrofolate reductase OS=... 290 4e-76
E7RAA3_PICAD (tr|E7RAA3) Methylenetetrahydrofolate reductase OS=... 290 7e-76
F9FK60_FUSOF (tr|F9FK60) Methylenetetrahydrofolate reductase OS=... 289 7e-76
E9ED23_METAQ (tr|E9ED23) Methylenetetrahydrofolate reductase OS=... 289 9e-76
J9MTN4_FUSO4 (tr|J9MTN4) Methylenetetrahydrofolate reductase OS=... 289 9e-76
K5X1L7_AGABU (tr|K5X1L7) Methylenetetrahydrofolate reductase OS=... 289 1e-75
K9I4E4_AGABB (tr|K9I4E4) Methylenetetrahydrofolate reductase OS=... 289 1e-75
G1X9G2_ARTOA (tr|G1X9G2) Methylenetetrahydrofolate reductase OS=... 288 1e-75
K1VJG4_TRIAC (tr|K1VJG4) Methylenetetrahydrofolate reductase OS=... 288 2e-75
J6F727_TRIAS (tr|J6F727) Methylenetetrahydrofolate reductase OS=... 288 2e-75
C5M851_CANTT (tr|C5M851) Methylenetetrahydrofolate reductase OS=... 288 2e-75
I1RYW1_GIBZE (tr|I1RYW1) Methylenetetrahydrofolate reductase OS=... 288 2e-75
G0T0T7_RHOG2 (tr|G0T0T7) Methylenetetrahydrofolate reductase OS=... 288 2e-75
G7DSI2_MIXOS (tr|G7DSI2) Methylenetetrahydrofolate reductase OS=... 288 2e-75
K3VHJ6_FUSPC (tr|K3VHJ6) Methylenetetrahydrofolate reductase OS=... 288 2e-75
C7Z4M2_NECH7 (tr|C7Z4M2) Methylenetetrahydrofolate reductase OS=... 288 2e-75
H6C648_EXODN (tr|H6C648) Methylenetetrahydrofolate reductase OS=... 288 2e-75
G2WQ21_VERDV (tr|G2WQ21) Methylenetetrahydrofolate reductase OS=... 288 2e-75
R7YW82_9EURO (tr|R7YW82) Methylenetetrahydrofolate reductase (NA... 288 2e-75
N1J4Z8_ERYGR (tr|N1J4Z8) Methylenetetrahydrofolate reductase OS=... 287 3e-75
G8JR06_ERECY (tr|G8JR06) Methylenetetrahydrofolate reductase OS=... 287 4e-75
M1WGQ3_CLAPU (tr|M1WGQ3) Methylenetetrahydrofolate reductase OS=... 287 4e-75
E9END5_METAR (tr|E9END5) Methylenetetrahydrofolate reductase OS=... 286 5e-75
E9AU75_LEIMU (tr|E9AU75) Methylenetetrahydrofolate reductase OS=... 286 6e-75
G7E669_MIXOS (tr|G7E669) Methylenetetrahydrofolate reductase OS=... 285 1e-74
G0S5U9_CHATD (tr|G0S5U9) Methylenetetrahydrofolate reductase OS=... 285 1e-74
R1BLH4_EMIHU (tr|R1BLH4) Putative methylenetetrahydrofolate redu... 284 3e-74
K1XFY5_MARBU (tr|K1XFY5) Methylenetetrahydrofolate reductase OS=... 284 3e-74
R1GCB8_9PEZI (tr|R1GCB8) Putative methylenetetrahydrofolate redu... 284 4e-74
N4VAU1_COLOR (tr|N4VAU1) Methylenetetrahydrofolate reductase 1 O... 283 5e-74
L7JK78_MAGOR (tr|L7JK78) Methylenetetrahydrofolate reductase OS=... 283 6e-74
L7IB80_MAGOR (tr|L7IB80) Methylenetetrahydrofolate reductase OS=... 283 6e-74
G4MV96_MAGO7 (tr|G4MV96) Methylenetetrahydrofolate reductase OS=... 283 6e-74
G0RA43_HYPJQ (tr|G0RA43) Methylenetetrahydrofolate reductase OS=... 283 7e-74
G2R3H5_THITE (tr|G2R3H5) Methylenetetrahydrofolate reductase OS=... 283 7e-74
G9MZ58_HYPVG (tr|G9MZ58) Methylenetetrahydrofolate reductase OS=... 283 7e-74
H1VMU2_COLHI (tr|H1VMU2) Methylenetetrahydrofolate reductase OS=... 282 1e-73
M5ED31_MALSM (tr|M5ED31) Genomic scaffold, msy_sf_16 OS=Malassez... 282 1e-73
R4XG29_9ASCO (tr|R4XG29) Methylenetetrahydrofolate reductase OS=... 282 1e-73
B0V153_DANRE (tr|B0V153) Methylenetetrahydrofolate reductase OS=... 282 1e-73
E3QQT1_COLGM (tr|E3QQT1) Methylenetetrahydrofolate reductase OS=... 282 1e-73
F9XCC6_MYCGM (tr|F9XCC6) Methylenetetrahydrofolate reductase OS=... 281 2e-73
Q2H0T7_CHAGB (tr|Q2H0T7) Methylenetetrahydrofolate reductase OS=... 281 2e-73
G9P292_HYPAI (tr|G9P292) Methylenetetrahydrofolate reductase OS=... 281 3e-73
M7SPP9_9PEZI (tr|M7SPP9) Putative methylenetetrahydrofolate redu... 281 3e-73
B6QPH8_PENMQ (tr|B6QPH8) Methylenetetrahydrofolate reductase OS=... 280 4e-73
G8ZXU8_TORDC (tr|G8ZXU8) Methylenetetrahydrofolate reductase OS=... 280 5e-73
H9MZH5_DANRE (tr|H9MZH5) Methylenetetrahydrofolate reductase OS=... 280 7e-73
E6R5R3_CRYGW (tr|E6R5R3) Methylenetetrahydrofolate reductase OS=... 279 8e-73
H2S3I1_TAKRU (tr|H2S3I1) Methylenetetrahydrofolate reductase OS=... 279 9e-73
Q4Q0B9_LEIMA (tr|Q4Q0B9) Methylenetetrahydrofolate reductase OS=... 279 1e-72
C5K575_PERM5 (tr|C5K575) Methylenetetrahydrofolate reductase OS=... 278 2e-72
A6RBU9_AJECN (tr|A6RBU9) Methylenetetrahydrofolate reductase OS=... 278 2e-72
K1QN08_CRAGI (tr|K1QN08) Methylenetetrahydrofolate reductase OS=... 278 2e-72
E9BV23_LEIDB (tr|E9BV23) Methylenetetrahydrofolate reductase OS=... 278 2e-72
A4IC95_LEIIN (tr|A4IC95) Methylenetetrahydrofolate reductase OS=... 278 2e-72
M7WNN9_RHOTO (tr|M7WNN9) Methylenetetrahydrofolate reductase (NA... 278 2e-72
B8M3Q9_TALSN (tr|B8M3Q9) Methylenetetrahydrofolate reductase OS=... 277 3e-72
B2B2M5_PODAN (tr|B2B2M5) Methylenetetrahydrofolate reductase OS=... 277 5e-72
G2Q3E8_THIHA (tr|G2Q3E8) Methylenetetrahydrofolate reductase OS=... 277 5e-72
J9VRV0_CRYNH (tr|J9VRV0) Methylenetetrahydrofolate reductase OS=... 276 5e-72
M3D6H6_9PEZI (tr|M3D6H6) Methylenetetrahydrofolate reductase OS=... 276 7e-72
B6K4Z7_SCHJY (tr|B6K4Z7) Methylenetetrahydrofolate reductase OS=... 276 7e-72
E4UPV6_ARTGP (tr|E4UPV6) Methylenetetrahydrofolate reductase OS=... 276 8e-72
H2MXI6_ORYLA (tr|H2MXI6) Methylenetetrahydrofolate reductase OS=... 276 1e-71
G3AY82_CANTC (tr|G3AY82) Methylenetetrahydrofolate reductase OS=... 275 1e-71
D5GMM8_TUBMM (tr|D5GMM8) Methylenetetrahydrofolate reductase OS=... 275 1e-71
H2YN67_CIOSA (tr|H2YN67) Methylenetetrahydrofolate reductase (Fr... 275 1e-71
E4ZHE6_LEPMJ (tr|E4ZHE6) Methylenetetrahydrofolate reductase OS=... 275 1e-71
R7UHV3_9ANNE (tr|R7UHV3) Uncharacterized protein OS=Capitella te... 275 2e-71
B7GB47_PHATC (tr|B7GB47) Methylenetetrahydrofolate reductase (Fr... 275 2e-71
H2YN66_CIOSA (tr|H2YN66) Methylenetetrahydrofolate reductase OS=... 275 2e-71
Q5K8Q9_CRYNJ (tr|Q5K8Q9) Methylenetetrahydrofolate reductase OS=... 274 3e-71
F5HGC8_CRYNB (tr|F5HGC8) Methylenetetrahydrofolate reductase OS=... 274 3e-71
B8BRT9_THAPS (tr|B8BRT9) Methylenetetrahydrofolate reductase (Fr... 274 3e-71
G8BYR2_TETPH (tr|G8BYR2) Methylenetetrahydrofolate reductase OS=... 273 5e-71
R0K2D2_SETTU (tr|R0K2D2) Uncharacterized protein OS=Setosphaeria... 273 5e-71
B2WMV1_PYRTR (tr|B2WMV1) Methylenetetrahydrofolate reductase OS=... 273 6e-71
B9WDQ7_CANDC (tr|B9WDQ7) Methylenetetrahydrofolate reductase OS=... 273 7e-71
Q0U6C4_PHANO (tr|Q0U6C4) Methylenetetrahydrofolate reductase OS=... 273 8e-71
M3ILJ3_CANMA (tr|M3ILJ3) Methylenetetrahydrofolate reductase OS=... 273 9e-71
N4WNX2_COCHE (tr|N4WNX2) Uncharacterized protein OS=Bipolaris ma... 272 9e-71
M2SSI3_COCHE (tr|M2SSI3) Methylenetetrahydrofolate reductase OS=... 272 9e-71
F0XGD2_GROCL (tr|F0XGD2) Methylenetetrahydrofolate reductase OS=... 272 9e-71
M4AE75_XIPMA (tr|M4AE75) Methylenetetrahydrofolate reductase OS=... 272 1e-70
Q5AEI0_CANAL (tr|Q5AEI0) Methylenetetrahydrofolate reductase OS=... 272 1e-70
C4YQ60_CANAW (tr|C4YQ60) Methylenetetrahydrofolate reductase OS=... 272 1e-70
E3RM42_PYRTT (tr|E3RM42) Methylenetetrahydrofolate reductase OS=... 272 1e-70
M2SQZ0_COCSA (tr|M2SQZ0) Methylenetetrahydrofolate reductase OS=... 272 1e-70
F7HIS1_CALJA (tr|F7HIS1) Methylenetetrahydrofolate reductase OS=... 272 1e-70
F7H2X2_CALJA (tr|F7H2X2) Methylenetetrahydrofolate reductase OS=... 272 1e-70
F6SM95_CALJA (tr|F6SM95) Methylenetetrahydrofolate reductase OS=... 272 1e-70
Q4T956_TETNG (tr|Q4T956) Methylenetetrahydrofolate reductase OS=... 272 1e-70
M9LZ85_9BASI (tr|M9LZ85) 5,10-methylenetetrahydrofolate reductas... 271 2e-70
G1SSR7_RABIT (tr|G1SSR7) Methylenetetrahydrofolate reductase OS=... 271 2e-70
H3CC89_TETNG (tr|H3CC89) Methylenetetrahydrofolate reductase OS=... 271 2e-70
N1PKU2_MYCPJ (tr|N1PKU2) Uncharacterized protein OS=Dothistroma ... 271 2e-70
H0X153_OTOGA (tr|H0X153) Methylenetetrahydrofolate reductase OS=... 271 3e-70
E6QYL4_CRYGW (tr|E6QYL4) Methylenetetrahydrofolate reductase OS=... 270 4e-70
A5DXM5_LODEL (tr|A5DXM5) Methylenetetrahydrofolate reductase OS=... 270 6e-70
G4TRD0_PIRID (tr|G4TRD0) Methylenetetrahydrofolate reductase OS=... 270 7e-70
B5RV11_DEBHA (tr|B5RV11) Methylenetetrahydrofolate reductase OS=... 270 7e-70
A7EWQ5_SCLS1 (tr|A7EWQ5) Methylenetetrahydrofolate reductase OS=... 270 7e-70
F8Q7Q5_SERL3 (tr|F8Q7Q5) Methylenetetrahydrofolate reductase OS=... 269 8e-70
F8P6Q6_SERL9 (tr|F8P6Q6) Methylenetetrahydrofolate reductase OS=... 269 8e-70
Q5SNW6_HUMAN (tr|Q5SNW6) Methylenetetrahydrofolate reductase OS=... 269 8e-70
L9L5F0_TUPCH (tr|L9L5F0) Methylenetetrahydrofolate reductase OS=... 269 9e-70
G3RAX7_GORGO (tr|G3RAX7) Methylenetetrahydrofolate reductase OS=... 269 9e-70
Q5KN82_CRYNJ (tr|Q5KN82) Methylenetetrahydrofolate reductase OS=... 269 1e-69
F5HHA5_CRYNB (tr|F5HHA5) Methylenetetrahydrofolate reductase OS=... 269 1e-69
H2PY11_PANTR (tr|H2PY11) Methylenetetrahydrofolate reductase OS=... 269 1e-69
K7C2K2_PANTR (tr|K7C2K2) Methylenetetrahydrofolate reductase OS=... 269 1e-69
K7DTF1_PANTR (tr|K7DTF1) Methylenetetrahydrofolate reductase OS=... 269 1e-69
M7UVH6_BOTFU (tr|M7UVH6) Putative methylenetetrahydrofolate redu... 268 1e-69
G2YUL6_BOTF4 (tr|G2YUL6) Methylenetetrahydrofolate reductase OS=... 268 1e-69
K1WUF3_TRIAC (tr|K1WUF3) Methylenetetrahydrofolate reductase OS=... 268 1e-69
J6EUJ9_TRIAS (tr|J6EUJ9) Methylenetetrahydrofolate reductase OS=... 268 1e-69
J4UUR5_BEAB2 (tr|J4UUR5) Methylenetetrahydrofolate reductase OS=... 268 1e-69
C5L500_PERM5 (tr|C5L500) Methylenetetrahydrofolate reductase OS=... 268 2e-69
C3XPI2_BRAFL (tr|C3XPI2) Methylenetetrahydrofolate reductase OS=... 268 2e-69
G3PGI0_GASAC (tr|G3PGI0) Methylenetetrahydrofolate reductase OS=... 268 2e-69
L5KGS1_PTEAL (tr|L5KGS1) Methylenetetrahydrofolate reductase OS=... 268 2e-69
B7G287_PHATC (tr|B7G287) Methylenetetrahydrofolate reductase OS=... 268 2e-69
G3PGH6_GASAC (tr|G3PGH6) Methylenetetrahydrofolate reductase (Fr... 268 2e-69
Q59GJ6_HUMAN (tr|Q59GJ6) Methylenetetrahydrofolate reductase (Fr... 268 2e-69
G1LTB1_AILME (tr|G1LTB1) Methylenetetrahydrofolate reductase OS=... 268 2e-69
D2HKB9_AILME (tr|D2HKB9) Methylenetetrahydrofolate reductase (Fr... 268 2e-69
F1RF82_PIG (tr|F1RF82) Methylenetetrahydrofolate reductase OS=Su... 267 3e-69
K9IVF1_PIG (tr|K9IVF1) Methylenetetrahydrofolate reductase OS=Su... 267 4e-69
J9VMK3_CRYNH (tr|J9VMK3) Methylenetetrahydrofolate reductase OS=... 267 4e-69
F6RK00_CIOIN (tr|F6RK00) Methylenetetrahydrofolate reductase OS=... 267 4e-69
Q7ZWU2_XENLA (tr|Q7ZWU2) Methylenetetrahydrofolate reductase OS=... 267 4e-69
E9HJT0_DAPPU (tr|E9HJT0) Methylenetetrahydrofolate reductase OS=... 267 4e-69
G8F4Z9_MACFA (tr|G8F4Z9) Methylenetetrahydrofolate reductase OS=... 267 4e-69
F7CI98_MACMU (tr|F7CI98) Methylenetetrahydrofolate reductase OS=... 267 4e-69
G3IHM4_CRIGR (tr|G3IHM4) Methylenetetrahydrofolate reductase OS=... 267 5e-69
H9FUQ0_MACMU (tr|H9FUQ0) Methylenetetrahydrofolate reductase OS=... 266 5e-69
K0TBA8_THAOC (tr|K0TBA8) Methylenetetrahydrofolate reductase OS=... 266 6e-69
M3YY87_MUSPF (tr|M3YY87) Methylenetetrahydrofolate reductase OS=... 266 6e-69
F7GJ76_MACMU (tr|F7GJ76) Methylenetetrahydrofolate reductase OS=... 266 6e-69
M2N3N4_9PEZI (tr|M2N3N4) Methylenetetrahydrofolate reductase OS=... 266 6e-69
F7CPK1_HORSE (tr|F7CPK1) Methylenetetrahydrofolate reductase OS=... 266 8e-69
I3MA17_SPETR (tr|I3MA17) Methylenetetrahydrofolate reductase (Fr... 266 8e-69
M3VU14_FELCA (tr|M3VU14) Methylenetetrahydrofolate reductase OS=... 266 1e-68
B0CSW4_LACBS (tr|B0CSW4) Methylenetetrahydrofolate reductase OS=... 265 1e-68
F6Z4F8_MOUSE (tr|F6Z4F8) Methylenetetrahydrofolate reductase (Fr... 265 2e-68
A2A7F7_MOUSE (tr|A2A7F7) Methylenetetrahydrofolate reductase OS=... 265 2e-68
Q3UDB2_MOUSE (tr|Q3UDB2) Methylenetetrahydrofolate reductase OS=... 265 2e-68
A3LUC7_PICST (tr|A3LUC7) Methylenetetrahydrofolate reductase OS=... 265 2e-68
Q6CKM1_KLULA (tr|Q6CKM1) Methylenetetrahydrofolate reductase OS=... 265 2e-68
K9J856_XENTR (tr|K9J856) Methylenetetrahydrofolate reductase OS=... 265 2e-68
G3JDV9_CORMM (tr|G3JDV9) Methylenetetrahydrofolate reductase OS=... 265 2e-68
A4IIX8_XENTR (tr|A4IIX8) Methylenetetrahydrofolate reductase OS=... 265 2e-68
L8IXC6_BOSMU (tr|L8IXC6) Methylenetetrahydrofolate reductase OS=... 264 3e-68
F6V3H1_XENTR (tr|F6V3H1) Methylenetetrahydrofolate reductase OS=... 264 3e-68
F1MF22_BOVIN (tr|F1MF22) Methylenetetrahydrofolate reductase OS=... 264 3e-68
B3S098_TRIAD (tr|B3S098) Methylenetetrahydrofolate reductase OS=... 264 3e-68
G8B6Z3_CANPC (tr|G8B6Z3) Methylenetetrahydrofolate reductase OS=... 264 4e-68
F7AQ98_MONDO (tr|F7AQ98) Methylenetetrahydrofolate reductase OS=... 264 4e-68
I3KND8_ORENI (tr|I3KND8) Methylenetetrahydrofolate reductase OS=... 264 4e-68
K7FMT0_PELSI (tr|K7FMT0) Methylenetetrahydrofolate reductase OS=... 264 4e-68
G3AQG4_SPAPN (tr|G3AQG4) Methylenetetrahydrofolate reductase OS=... 263 4e-68
I1FJF2_AMPQE (tr|I1FJF2) Methylenetetrahydrofolate reductase OS=... 263 5e-68
M5E942_MALSM (tr|M5E942) Genomic scaffold, msy_sf_9 OS=Malassezi... 263 6e-68
K7FMS5_PELSI (tr|K7FMS5) Methylenetetrahydrofolate reductase OS=... 263 6e-68
G8YAU9_PICSO (tr|G8YAU9) Methylenetetrahydrofolate reductase OS=... 263 6e-68
C4Y415_CLAL4 (tr|C4Y415) Methylenetetrahydrofolate reductase OS=... 263 7e-68
R0JRL3_ANAPL (tr|R0JRL3) Methylenetetrahydrofolate reductase (Fr... 263 9e-68
E2QXW9_CANFA (tr|E2QXW9) Methylenetetrahydrofolate reductase OS=... 262 1e-67
H3AKG0_LATCH (tr|H3AKG0) Methylenetetrahydrofolate reductase OS=... 262 1e-67
M3ARN4_9PEZI (tr|M3ARN4) Methylenetetrahydrofolate reductase OS=... 262 1e-67
E1BXL1_CHICK (tr|E1BXL1) Methylenetetrahydrofolate reductase OS=... 262 2e-67
I1KG06_SOYBN (tr|I1KG06) Methylenetetrahydrofolate reductase OS=... 261 2e-67
M7BWD2_CHEMY (tr|M7BWD2) Methylenetetrahydrofolate reductase OS=... 261 2e-67
K5W8I5_PHACS (tr|K5W8I5) Methylenetetrahydrofolate reductase OS=... 261 2e-67
G1N3J8_MELGA (tr|G1N3J8) Methylenetetrahydrofolate reductase (Fr... 261 3e-67
M5GA04_DACSP (tr|M5GA04) MTHFR-domain-containing protein OS=Dacr... 260 5e-67
G3AM20_SPAPN (tr|G3AM20) Methylenetetrahydrofolate reductase OS=... 260 5e-67
J3S088_CROAD (tr|J3S088) Methylenetetrahydrofolate reductase OS=... 259 8e-67
E6ZVM6_SPORE (tr|E6ZVM6) Methylenetetrahydrofolate reductase OS=... 259 9e-67
H8X156_CANO9 (tr|H8X156) Methylenetetrahydrofolate reductase OS=... 259 1e-66
G4UIN5_NEUT9 (tr|G4UIN5) Methylenetetrahydrofolate reductase OS=... 259 1e-66
F8MJ09_NEUT8 (tr|F8MJ09) Methylenetetrahydrofolate reductase OS=... 259 1e-66
Q7S830_NEUCR (tr|Q7S830) Methylenetetrahydrofolate reductase OS=... 259 1e-66
H0UZL8_CAVPO (tr|H0UZL8) Methylenetetrahydrofolate reductase (Fr... 258 1e-66
N4UDI4_FUSOX (tr|N4UDI4) Methylenetetrahydrofolate reductase 1 O... 258 2e-66
G3T6N6_LOXAF (tr|G3T6N6) Methylenetetrahydrofolate reductase OS=... 258 2e-66
I2H5Z0_TETBL (tr|I2H5Z0) Methylenetetrahydrofolate reductase OS=... 258 2e-66
K3WFD4_PYTUL (tr|K3WFD4) Methylenetetrahydrofolate reductase OS=... 258 3e-66
M4BSS5_HYAAE (tr|M4BSS5) Methylenetetrahydrofolate reductase OS=... 257 4e-66
F1KZ16_ASCSU (tr|F1KZ16) Methylenetetrahydrofolate reductase OS=... 256 7e-66
H0ZU30_TAEGU (tr|H0ZU30) Methylenetetrahydrofolate reductase OS=... 256 9e-66
M4FNZ6_MAGP6 (tr|M4FNZ6) Methylenetetrahydrofolate reductase OS=... 256 1e-65
H0EVR8_GLAL7 (tr|H0EVR8) Methylenetetrahydrofolate reductase OS=... 256 1e-65
H0YVV8_TAEGU (tr|H0YVV8) Methylenetetrahydrofolate reductase OS=... 255 1e-65
F7VNA4_SORMK (tr|F7VNA4) Methylenetetrahydrofolate reductase OS=... 255 2e-65
J3NNB0_GAGT3 (tr|J3NNB0) Methylenetetrahydrofolate reductase OS=... 255 2e-65
J3QDS4_PUCT1 (tr|J3QDS4) Methylenetetrahydrofolate reductase OS=... 254 3e-65
R9NZU2_9BASI (tr|R9NZU2) Methylenetetrahydrofolate reductase OS=... 254 3e-65
A3LW82_PICST (tr|A3LW82) Methylenetetrahydrofolate reductase OS=... 254 3e-65
Q4P1E8_USTMA (tr|Q4P1E8) Methylenetetrahydrofolate reductase OS=... 254 3e-65
G1PJ01_MYOLU (tr|G1PJ01) Methylenetetrahydrofolate reductase OS=... 253 6e-65
F2UPH6_SALS5 (tr|F2UPH6) Methylenetetrahydrofolate reductase OS=... 252 2e-64
D4A7E8_RAT (tr|D4A7E8) Methylenetetrahydrofolate reductase OS=Ra... 252 2e-64
R8BDU8_9PEZI (tr|R8BDU8) Putative methylenetetrahydrofolate redu... 251 2e-64
F0WFI8_9STRA (tr|F0WFI8) Methylenetetrahydrofolate reductase OS=... 251 2e-64
F6TEC5_ORNAN (tr|F6TEC5) Methylenetetrahydrofolate reductase OS=... 250 4e-64
M3K3T4_CANMA (tr|M3K3T4) Methylenetetrahydrofolate reductase OS=... 250 5e-64
M7WXP1_RHOTO (tr|M7WXP1) Methylenetetrahydrofolate reductase (NA... 249 9e-64
G5C506_HETGA (tr|G5C506) Methylenetetrahydrofolate reductase OS=... 249 1e-63
L8G9A3_GEOD2 (tr|L8G9A3) Methylenetetrahydrofolate reductase OS=... 248 2e-63
L2FEI5_COLGN (tr|L2FEI5) Methylenetetrahydrofolate reductase OS=... 248 2e-63
D8PVA5_SCHCM (tr|D8PVA5) Methylenetetrahydrofolate reductase OS=... 248 3e-63
Q5A5S8_CANAL (tr|Q5A5S8) Methylenetetrahydrofolate reductase OS=... 248 3e-63
A1CZX0_NEOFI (tr|A1CZX0) Methylenetetrahydrofolate reductase OS=... 247 3e-63
G8BIZ7_CANPC (tr|G8BIZ7) Methylenetetrahydrofolate reductase OS=... 247 4e-63
F2QR20_PICP7 (tr|F2QR20) Methylenetetrahydrofolate reductase OS=... 247 4e-63
K2QJU3_MACPH (tr|K2QJU3) Methylenetetrahydrofolate reductase OS=... 247 5e-63
Q6CEM7_YARLI (tr|Q6CEM7) Methylenetetrahydrofolate reductase OS=... 247 5e-63
A5DE00_PICGU (tr|A5DE00) Methylenetetrahydrofolate reductase OS=... 246 6e-63
F0XLK7_GROCL (tr|F0XLK7) Methylenetetrahydrofolate reductase OS=... 246 7e-63
C4YKV3_CANAW (tr|C4YKV3) Methylenetetrahydrofolate reductase OS=... 246 9e-63
H0EJ23_GLAL7 (tr|H0EJ23) Methylenetetrahydrofolate reductase OS=... 246 1e-62
C5M548_CANTT (tr|C5M548) Methylenetetrahydrofolate reductase OS=... 245 2e-62
K1WXP9_MARBU (tr|K1WXP9) Methylenetetrahydrofolate reductase OS=... 245 2e-62
B0Y2U3_ASPFC (tr|B0Y2U3) Methylenetetrahydrofolate reductase OS=... 244 2e-62
Q4WEL9_ASPFU (tr|Q4WEL9) Methylenetetrahydrofolate reductase OS=... 244 3e-62
H8X3U3_CANO9 (tr|H8X3U3) Methylenetetrahydrofolate reductase OS=... 244 4e-62
Q0CE17_ASPTN (tr|Q0CE17) Methylenetetrahydrofolate reductase OS=... 243 5e-62
Q60CG9_METCA (tr|Q60CG9) Methylenetetrahydrofolate reductase OS=... 243 6e-62
C5FI42_ARTOC (tr|C5FI42) Methylenetetrahydrofolate reductase OS=... 243 6e-62
Q5AU15_EMENI (tr|Q5AU15) Methylenetetrahydrofolate reductase OS=... 243 7e-62
Q0GA68_EMEND (tr|Q0GA68) Methylenetetrahydrofolate reductase OS=... 243 7e-62
E9CFC5_CAPO3 (tr|E9CFC5) Methylenetetrahydrofolate reductase OS=... 243 8e-62
Q6BM19_DEBHA (tr|Q6BM19) Methylenetetrahydrofolate reductase OS=... 243 8e-62
B9WCV3_CANDC (tr|B9WCV3) Methylenetetrahydrofolate reductase OS=... 243 9e-62
G7XN52_ASPKW (tr|G7XN52) Methylenetetrahydrofolate reductase OS=... 243 1e-61
C4JM22_UNCRE (tr|C4JM22) Methylenetetrahydrofolate reductase OS=... 243 1e-61
E4URV2_ARTGP (tr|E4URV2) Methylenetetrahydrofolate reductase OS=... 242 1e-61
F2SNP6_TRIRC (tr|F2SNP6) Methylenetetrahydrofolate reductase OS=... 242 1e-61
C4Y9Q4_CLAL4 (tr|C4Y9Q4) Methylenetetrahydrofolate reductase OS=... 242 1e-61
K2S237_MACPH (tr|K2S237) Methylenetetrahydrofolate reductase OS=... 242 1e-61
K5XGF3_AGABU (tr|K5XGF3) Methylenetetrahydrofolate reductase OS=... 242 1e-61
A1C4Z1_ASPCL (tr|A1C4Z1) Methylenetetrahydrofolate reductase OS=... 241 2e-61
A7S360_NEMVE (tr|A7S360) Methylenetetrahydrofolate reductase OS=... 241 2e-61
B8NQE8_ASPFN (tr|B8NQE8) Methylenetetrahydrofolate reductase OS=... 241 3e-61
G3XLM4_ASPNA (tr|G3XLM4) Methylenetetrahydrofolate reductase OS=... 241 3e-61
B4D0K5_9BACT (tr|B4D0K5) Methylenetetrahydrofolate reductase OS=... 241 3e-61
G8YA65_PICSO (tr|G8YA65) Methylenetetrahydrofolate reductase OS=... 241 3e-61
K7HSL3_CAEJA (tr|K7HSL3) Methylenetetrahydrofolate reductase OS=... 241 4e-61
H6BSG9_EXODN (tr|H6BSG9) Methylenetetrahydrofolate reductase OS=... 241 4e-61
D4AR17_ARTBC (tr|D4AR17) Methylenetetrahydrofolate reductase OS=... 240 4e-61
Q2UA39_ASPOR (tr|Q2UA39) Methylenetetrahydrofolate reductase OS=... 240 5e-61
I8A5G3_ASPO3 (tr|I8A5G3) Methylenetetrahydrofolate reductase OS=... 240 5e-61
H2W4Y4_CAEJA (tr|H2W4Y4) Methylenetetrahydrofolate reductase (Fr... 240 6e-61
C5DPF1_ZYGRC (tr|C5DPF1) Methylenetetrahydrofolate reductase OS=... 239 7e-61
D4DDN3_TRIVH (tr|D4DDN3) Methylenetetrahydrofolate reductase OS=... 239 7e-61
B6QFH8_PENMQ (tr|B6QFH8) Methylenetetrahydrofolate reductase OS=... 239 1e-60
B9XQY3_9BACT (tr|B9XQY3) Methylenetetrahydrofolate reductase OS=... 238 2e-60
R4XEG2_9ASCO (tr|R4XEG2) Uncharacterized protein OS=Taphrina def... 238 2e-60
R1GLW2_9PEZI (tr|R1GLW2) Putative methylenetetrahydrofolate redu... 238 2e-60
A2QUJ5_ASPNC (tr|A2QUJ5) Methylenetetrahydrofolate reductase OS=... 238 2e-60
L8GA37_GEOD2 (tr|L8GA37) Methylenetetrahydrofolate reductase OS=... 238 2e-60
N4W0R1_COLOR (tr|N4W0R1) Methylenetetrahydrofolate reductase OS=... 238 2e-60
H1VQF9_COLHI (tr|H1VQF9) Methylenetetrahydrofolate reductase OS=... 238 2e-60
F2QR60_PICP7 (tr|F2QR60) Methylenetetrahydrofolate reductase OS=... 238 2e-60
C4R2L4_PICPG (tr|C4R2L4) Methylenetetrahydrofolate reductase OS=... 238 2e-60
G8JXY2_CAEEL (tr|G8JXY2) Methylenetetrahydrofolate reductase OS=... 238 2e-60
L7J0Y9_MAGOR (tr|L7J0Y9) Methylenetetrahydrofolate reductase OS=... 238 3e-60
L7IP25_MAGOR (tr|L7IP25) Methylenetetrahydrofolate reductase OS=... 238 3e-60
G4MZ63_MAGO7 (tr|G4MZ63) Methylenetetrahydrofolate reductase OS=... 238 3e-60
D7BAR9_MEISD (tr|D7BAR9) Methylenetetrahydrofolate reductase OS=... 238 3e-60
B2WHR5_PYRTR (tr|B2WHR5) Methylenetetrahydrofolate reductase OS=... 238 3e-60
H3G9J6_PHYRM (tr|H3G9J6) Methylenetetrahydrofolate reductase OS=... 238 3e-60
F9XHC5_MYCGM (tr|F9XHC5) Methylenetetrahydrofolate reductase OS=... 238 3e-60
K9I5Z0_AGABB (tr|K9I5Z0) Methylenetetrahydrofolate reductase OS=... 238 3e-60
J4H1L8_FIBRA (tr|J4H1L8) Methylenetetrahydrofolate reductase OS=... 237 3e-60
F2PS11_TRIEC (tr|F2PS11) Methylenetetrahydrofolate reductase OS=... 237 4e-60
M7SBI3_9PEZI (tr|M7SBI3) Putative methylenetetrahydrofolate redu... 237 4e-60
M2YPU3_MYCPJ (tr|M2YPU3) Methylenetetrahydrofolate reductase OS=... 237 5e-60
G1X2G4_ARTOA (tr|G1X2G4) Methylenetetrahydrofolate reductase OS=... 237 5e-60
B8MDD4_TALSN (tr|B8MDD4) Methylenetetrahydrofolate reductase OS=... 236 6e-60
G0RUZ1_HYPJQ (tr|G0RUZ1) Methylenetetrahydrofolate reductase OS=... 236 6e-60
G4ZJB0_PHYSP (tr|G4ZJB0) Methylenetetrahydrofolate reductase OS=... 236 8e-60
F4S8A9_MELLP (tr|F4S8A9) Methylenetetrahydrofolate reductase OS=... 236 8e-60
E9F4X1_METAR (tr|E9F4X1) Methylenetetrahydrofolate reductase OS=... 236 1e-59
E9DBB1_COCPS (tr|E9DBB1) Methylenetetrahydrofolate reductase OS=... 235 1e-59
E3S600_PYRTT (tr|E3S600) Methylenetetrahydrofolate reductase OS=... 235 1e-59
E3QAK3_COLGM (tr|E3QAK3) Methylenetetrahydrofolate reductase OS=... 235 1e-59
N1QKG8_9PEZI (tr|N1QKG8) Methylenetetrahydrofolate reductase 2 O... 235 2e-59
C1H0K0_PARBA (tr|C1H0K0) Methylenetetrahydrofolate reductase OS=... 235 2e-59
J3K922_COCIM (tr|J3K922) Methylenetetrahydrofolate reductase OS=... 235 2e-59
M1VXE2_CLAPU (tr|M1VXE2) Methylenetetrahydrofolate reductase OS=... 235 2e-59
M2QM94_CERSU (tr|M2QM94) Methylenetetrahydrofolate reductase OS=... 235 2e-59
C5P4Q4_COCP7 (tr|C5P4Q4) Methylenetetrahydrofolate reductase OS=... 235 2e-59
A7E9M9_SCLS1 (tr|A7E9M9) Methylenetetrahydrofolate reductase OS=... 235 2e-59
R0IFT1_SETTU (tr|R0IFT1) Uncharacterized protein OS=Setosphaeria... 234 2e-59
M4G477_MAGP6 (tr|M4G477) Methylenetetrahydrofolate reductase OS=... 234 2e-59
E9DS87_METAQ (tr|E9DS87) Methylenetetrahydrofolate reductase OS=... 234 3e-59
E3MN18_CAERE (tr|E3MN18) Methylenetetrahydrofolate reductase OS=... 234 4e-59
D5G9J4_TUBMM (tr|D5G9J4) Methylenetetrahydrofolate reductase OS=... 234 4e-59
J8TI80_SACK1 (tr|J8TI80) Methylenetetrahydrofolate reductase OS=... 234 4e-59
H0H279_9SACH (tr|H0H279) Methylenetetrahydrofolate reductase OS=... 234 4e-59
J3NGV8_GAGT3 (tr|J3NGV8) Methylenetetrahydrofolate reductase OS=... 234 4e-59
I2FQ18_USTH4 (tr|I2FQ18) Methylenetetrahydrofolate reductase OS=... 234 4e-59
G2QSW3_THITE (tr|G2QSW3) Methylenetetrahydrofolate reductase OS=... 234 5e-59
D3FCP0_CONWI (tr|D3FCP0) Methylenetetrahydrofolate reductase OS=... 233 5e-59
G9MEA0_HYPVG (tr|G9MEA0) Methylenetetrahydrofolate reductase OS=... 233 6e-59
M3AX30_9PEZI (tr|M3AX30) Methylenetetrahydrofolate reductase OS=... 233 6e-59
G2Q8K5_THIHA (tr|G2Q8K5) Methylenetetrahydrofolate reductase OS=... 233 6e-59
G0SG99_CHATD (tr|G0SG99) Methylenetetrahydrofolate reductase OS=... 233 7e-59
M9N544_ASHGS (tr|M9N544) FAFR457Wp OS=Ashbya gossypii FDAG1 GN=F... 233 9e-59
A8PV87_BRUMA (tr|A8PV87) Methylenetetrahydrofolate reductase OS=... 233 9e-59
Q752W6_ASHGO (tr|Q752W6) Methylenetetrahydrofolate reductase OS=... 233 9e-59
M7TPI8_BOTFU (tr|M7TPI8) Putative methylenetetrahydrofolate redu... 233 9e-59
G2Y122_BOTF4 (tr|G2Y122) Methylenetetrahydrofolate reductase OS=... 233 9e-59
H8MPX1_CORCM (tr|H8MPX1) Methylenetetrahydrofolate reductase OS=... 233 9e-59
L7U9T6_MYXSD (tr|L7U9T6) Methylenetetrahydrofolate reductase OS=... 233 1e-58
G2XE28_VERDV (tr|G2XE28) Methylenetetrahydrofolate reductase OS=... 232 1e-58
C9S8T9_VERA1 (tr|C9S8T9) Methylenetetrahydrofolate reductase OS=... 232 1e-58
G9NF79_HYPAI (tr|G9NF79) Methylenetetrahydrofolate reductase OS=... 232 1e-58
M2SJN6_COCSA (tr|M2SJN6) Methylenetetrahydrofolate reductase OS=... 232 1e-58
R8BQ93_9PEZI (tr|R8BQ93) Putative methylenetetrahydrofolate redu... 231 2e-58
K9FXA7_PEND1 (tr|K9FXA7) Methylenetetrahydrofolate reductase OS=... 231 2e-58
K9FMU0_PEND2 (tr|K9FMU0) Methylenetetrahydrofolate reductase OS=... 231 2e-58
E7Q9Y6_YEASB (tr|E7Q9Y6) Methylenetetrahydrofolate reductase OS=... 231 3e-58
C7YTQ6_NECH7 (tr|C7YTQ6) Methylenetetrahydrofolate reductase OS=... 231 3e-58
G3JKM4_CORMM (tr|G3JKM4) Methylenetetrahydrofolate reductase OS=... 231 3e-58
A8XGR9_CAEBR (tr|A8XGR9) Methylenetetrahydrofolate reductase OS=... 231 4e-58
N1P1U1_YEASX (tr|N1P1U1) Met12p OS=Saccharomyces cerevisiae CEN.... 231 4e-58
E5AEI4_LEPMJ (tr|E5AEI4) Methylenetetrahydrofolate reductase OS=... 230 5e-58
>I3S0L6_LOTJA (tr|I3S0L6) Methylenetetrahydrofolate reductase OS=Lotus japonicus
PE=2 SV=1
Length = 340
Score = 668 bits (1723), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 322/323 (99%), Positives = 322/323 (99%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKIHEAAASDPNKVVFSFEFFPPKTE GVVNLLERMDRMVAHSPSFCDITWGAGGS
Sbjct: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEGGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ
Sbjct: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY
Sbjct: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK
Sbjct: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
Query: 301 NLGLIEETSIPRTRPANAIQAKE 323
NLGLIEETSIPRTRPANAIQAKE
Sbjct: 301 NLGLIEETSIPRTRPANAIQAKE 323
>I1JZE1_SOYBN (tr|I1JZE1) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 596
Score = 592 bits (1525), Expect = e-167, Method: Compositional matrix adjust.
Identities = 284/327 (86%), Positives = 302/327 (92%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKI AA++DPN+VVFSFEFFPPKTEDGV NL ERMDRMVAH+PSFCDITWGAGG+
Sbjct: 1 MKIIEKIR-AASADPNRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGT 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETMMHLTCTNMPVEKID AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLV+HIRAK+GDYFGITIAGYPEAHPD I S+GLATPE Y+NDL Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITIAGYPEAHPDVIESDGLATPEGYRNDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+IMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEE+ S+P RPAN + KE
Sbjct: 300 NLGLIEESKVSRSLPWRRPANVFRVKE 326
>I1JZE2_SOYBN (tr|I1JZE2) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 595
Score = 592 bits (1525), Expect = e-167, Method: Compositional matrix adjust.
Identities = 284/327 (86%), Positives = 302/327 (92%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKI AA++DPN+VVFSFEFFPPKTEDGV NL ERMDRMVAH+PSFCDITWGAGG+
Sbjct: 1 MKIIEKIR-AASADPNRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGT 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETMMHLTCTNMPVEKID AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLV+HIRAK+GDYFGITIAGYPEAHPD I S+GLATPE Y+NDL Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITIAGYPEAHPDVIESDGLATPEGYRNDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+IMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEE+ S+P RPAN + KE
Sbjct: 300 NLGLIEESKVSRSLPWRRPANVFRVKE 326
>I1KG02_SOYBN (tr|I1KG02) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 595
Score = 590 bits (1522), Expect = e-166, Method: Compositional matrix adjust.
Identities = 283/327 (86%), Positives = 300/327 (91%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKIH AA++DPN+VVFSFEFFPPKTEDGV NL ERMDRMV H+PSFCDITWGAGG+
Sbjct: 1 MKIIEKIH-AASADPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWGAGGT 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETMMHLTCTNMPVEKID AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLV+HIRAK+GDYFGIT+AGYPEAHPD I S+GLAT E YQNDL Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+IMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG TLHLYTLN+EKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEET S+P RPAN + KE
Sbjct: 300 NLGLIEETKVSRSLPWRRPANVFRVKE 326
>I1KG04_SOYBN (tr|I1KG04) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 571
Score = 590 bits (1522), Expect = e-166, Method: Compositional matrix adjust.
Identities = 283/327 (86%), Positives = 300/327 (91%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKIH AA++DPN+VVFSFEFFPPKTEDGV NL ERMDRMV H+PSFCDITWGAGG+
Sbjct: 1 MKIIEKIH-AASADPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWGAGGT 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETMMHLTCTNMPVEKID AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLV+HIRAK+GDYFGIT+AGYPEAHPD I S+GLAT E YQNDL Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+IMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG TLHLYTLN+EKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEET S+P RPAN + KE
Sbjct: 300 NLGLIEETKVSRSLPWRRPANVFRVKE 326
>I1KG03_SOYBN (tr|I1KG03) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 462
Score = 588 bits (1517), Expect = e-166, Method: Compositional matrix adjust.
Identities = 283/327 (86%), Positives = 300/327 (91%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKIH AA++DPN+VVFSFEFFPPKTEDGV NL ERMDRMV H+PSFCDITWGAGG+
Sbjct: 1 MKIIEKIH-AASADPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWGAGGT 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETMMHLTCTNMPVEKID AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLV+HIRAK+GDYFGIT+AGYPEAHPD I S+GLAT E YQNDL Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+IMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG TLHLYTLN+EKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEET S+P RPAN + KE
Sbjct: 300 NLGLIEETKVSRSLPWRRPANVFRVKE 326
>C6T731_SOYBN (tr|C6T731) Methylenetetrahydrofolate reductase OS=Glycine max PE=1
SV=1
Length = 344
Score = 577 bits (1488), Expect = e-162, Method: Compositional matrix adjust.
Identities = 276/320 (86%), Positives = 293/320 (91%), Gaps = 1/320 (0%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKIH AA++DPN+VVFSFEFFPPKTEDGV NL ERMDRMV H+PSFCDITW AGG+
Sbjct: 1 MKIIEKIH-AASADPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWSAGGT 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETMMHLTCTNMPVEKID AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACARDLV+HIRAK+GDYFGIT+AGYPEAHPD I S+GLAT E YQNDL Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+IMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG TLHLYTLN+EKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEETSIPRTRPANAIQ 320
NLGLIEET +A+Q
Sbjct: 300 NLGLIEETKFLGPYLGDALQ 319
>B9HG95_POPTR (tr|B9HG95) Methylenetetrahydrofolate reductase OS=Populus
trichocarpa GN=MTHFR1 PE=3 SV=1
Length = 608
Score = 576 bits (1485), Expect = e-162, Method: Compositional matrix adjust.
Identities = 279/339 (82%), Positives = 297/339 (87%), Gaps = 16/339 (4%)
Query: 1 MKVIEKIHEAAA------------SDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSP 48
MKVI+KI EAA S NKVVFSFEFFPPKTEDGV NL ERMDRMVAH+P
Sbjct: 1 MKVIDKIREAAGGGGDANGNGGDNSSSNKVVFSFEFFPPKTEDGVDNLFERMDRMVAHNP 60
Query: 49 SFCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQN 108
SFCDITWGAGGSTAD+TLDIA KMQN + VETMMHLTCTNMPVEKID ALETIKSNG+QN
Sbjct: 61 SFCDITWGAGGSTADLTLDIANKMQNIICVETMMHLTCTNMPVEKIDHALETIKSNGIQN 120
Query: 109 VLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGL 168
VLALRGDPPHGQDKFVQ++GGFACA DLVKHIR+K+GDYFGIT+AGYPEAHPDAIGS+G
Sbjct: 121 VLALRGDPPHGQDKFVQIQGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDAIGSDGF 180
Query: 169 ATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINN 228
ATPEDYQ DL YLK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINN
Sbjct: 181 ATPEDYQKDLAYLKQKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINN 240
Query: 229 YKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYT 288
YKGF+RMTGFCKTKIPAE+ AALEPIKDNEEAV+AYGIHLGTEMCKKILAHG KTLHLYT
Sbjct: 241 YKGFLRMTGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYT 300
Query: 289 LNLEKSALAILKNLGLIEETSI----PRTRPANAIQAKE 323
LN+EKSALAIL NLGLIEE+ I P P N +AKE
Sbjct: 301 LNMEKSALAILMNLGLIEESKITRALPWRPPTNVFRAKE 339
>M5W952_PRUPE (tr|M5W952) Uncharacterized protein OS=Prunus persica
GN=PRUPE_ppa003184mg PE=4 SV=1
Length = 595
Score = 572 bits (1473), Expect = e-161, Method: Compositional matrix adjust.
Identities = 271/327 (82%), Positives = 297/327 (90%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EA + KV+FSFEFFPPKTEDGV NLLERM+RMVAH+P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEALLEE-KKVLFSFEFFPPKTEDGVENLLERMERMVAHNPAFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA KMQN + VE+MMHLTCTNMPV+KID AL+TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLDIANKMQNIICVESMMHLTCTNMPVDKIDHALQTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQ++GGFACA DLV HIRAK+GDYFG+T+AGYPEAHPDAIG++GLA+PE YQ+DL Y
Sbjct: 120 DKFVQIQGGFACALDLVTHIRAKYGDYFGVTVAGYPEAHPDAIGTDGLASPEAYQSDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTD+FLKF +DCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKRKVDAGADLIITQLFYDTDVFLKFVHDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+ AALEPIKDNEEAVK+YGIHLGTEMCKKILAHG +TLHLYTLN+EKSALAIL
Sbjct: 240 TKIPAEVTAALEPIKDNEEAVKSYGIHLGTEMCKKILAHGIRTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEET I P RPAN + KE
Sbjct: 300 NLGLIEETKISRPLPWRRPANVFRVKE 326
>J7EQB2_TOBAC (tr|J7EQB2) Methylenetetrahydrofolate reductase OS=Nicotiana
tabacum PE=2 SV=1
Length = 595
Score = 572 bits (1473), Expect = e-161, Method: Compositional matrix adjust.
Identities = 274/327 (83%), Positives = 294/327 (89%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA D N+VVFSFEFFPPKTEDGV NL ERM+RMVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAA-KDENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+K+MQN V VETMMHLTCTNMPVEKID AL+TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQ+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKE 326
>J7EPI5_NICTO (tr|J7EPI5) Methylenetetrahydrofolate reductase OS=Nicotiana
tomentosiformis PE=2 SV=1
Length = 595
Score = 572 bits (1473), Expect = e-161, Method: Compositional matrix adjust.
Identities = 274/327 (83%), Positives = 294/327 (89%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA D N+VVFSFEFFPPKTEDGV NL ERM+RMVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAA-KDENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+K+MQN V VETMMHLTCTNMPVEKID AL+TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQ+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKE 326
>J7EQ04_NICSY (tr|J7EQ04) Methylenetetrahydrofolate reductase OS=Nicotiana
sylvestris PE=2 SV=1
Length = 595
Score = 570 bits (1469), Expect = e-160, Method: Compositional matrix adjust.
Identities = 273/327 (83%), Positives = 294/327 (89%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA D N+VVFSFEFFPPKTEDGV NL ERM+RMVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAA-KDENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+K+MQN V VETMMHLTCTNMPVEKID AL+TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN++KSAL+IL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMKKSALSILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKE 326
>J7EPU9_TOBAC (tr|J7EPU9) Methylenetetrahydrofolate reductase OS=Nicotiana
tabacum PE=2 SV=1
Length = 595
Score = 570 bits (1468), Expect = e-160, Method: Compositional matrix adjust.
Identities = 273/327 (83%), Positives = 294/327 (89%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA D N+VVFSFEFFPPKTEDGV NL ERM+RMVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAA-KDENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+K+MQN V VETMMHLTCTNMPVEKID AL+TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKD+EEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSAL+IL
Sbjct: 240 TKIPEEIMAALEPIKDSEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALSILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKE 326
>M1BBU4_SOLTU (tr|M1BBU4) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400016168 PE=3 SV=1
Length = 594
Score = 568 bits (1463), Expect = e-159, Method: Compositional matrix adjust.
Identities = 270/327 (82%), Positives = 293/327 (89%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA +D KV+FSFEFFPPKT+DGV NL ERM+RMVAHSPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAKTD--KVIFSFEFFPPKTDDGVENLFERMERMVAHSPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDI +MQN V VE+MMHLTCTNMPVEKID AL+TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIVNRMQNMVCVESMMHLTCTNMPVEKIDHALDTIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKH+RAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPANGIATKEIYENDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+I+TQLFYDTD+FLKF NDCRQIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKKKVDAGADVIVTQLFYDTDVFLKFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSALAIL
Sbjct: 239 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RPAN + KE
Sbjct: 299 NLGLIEESKISRPLPWRRPANVFRVKE 325
>J7EQB1_NICTO (tr|J7EQB1) Methylenetetrahydrofolate reductase OS=Nicotiana
tomentosiformis PE=2 SV=1
Length = 595
Score = 568 bits (1463), Expect = e-159, Method: Compositional matrix adjust.
Identities = 272/327 (83%), Positives = 292/327 (89%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA D N+VVFSFEFFPPKTEDGV NL ERM+RMVAH+PSFCDITWGAGG
Sbjct: 1 MKVIEKIQEAA-KDENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGP 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+K+MQN V VETMMHLTCTNMPVEKID AL+TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQ+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMA LEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPEEIMAVLEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKE 326
>J7EPV1_NICTO (tr|J7EPV1) Methylenetetrahydrofolate reductase OS=Nicotiana
tomentosiformis PE=2 SV=1
Length = 595
Score = 566 bits (1459), Expect = e-159, Method: Compositional matrix adjust.
Identities = 272/327 (83%), Positives = 293/327 (89%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI + AA D N+VVFSFEFFPPKTEDGV NL ERM+ MVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKI-QGAAKDENRVVFSFEFFPPKTEDGVENLFERMEGMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+K+MQN V VETMMHLTCTNMPVEKID AL+TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQ+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKE 326
>K4D5E7_SOLLC (tr|K4D5E7) Methylenetetrahydrofolate reductase OS=Solanum
lycopersicum GN=Solyc11g008870.1 PE=3 SV=1
Length = 594
Score = 563 bits (1450), Expect = e-158, Method: Compositional matrix adjust.
Identities = 269/327 (82%), Positives = 292/327 (89%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA +D KV+FSFEFFPPKT+DGV NL ERM+RMVAH PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAKTD--KVIFSFEFFPPKTDDGVENLFERMERMVAHGPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I +MQN V VE+MMHLTCTNMPVEKID AL+TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIVNRMQNMVCVESMMHLTCTNMPVEKIDHALDTIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKH+RAK+GDYFGIT+AGYPEAHPD I +NG+AT E Y+NDL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPANGIATKEIYENDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+I+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKKKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP EIMAALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSALAIL
Sbjct: 239 TKIPDEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RPAN + KE
Sbjct: 299 NLGLIEESKISRPLPWRRPANIFRVKE 325
>B9N8L0_POPTR (tr|B9N8L0) Methylenetetrahydrofolate reductase OS=Populus
trichocarpa GN=MTHFR2 PE=2 SV=1
Length = 606
Score = 562 bits (1448), Expect = e-158, Method: Compositional matrix adjust.
Identities = 271/336 (80%), Positives = 290/336 (86%), Gaps = 13/336 (3%)
Query: 1 MKVIEKIHEAAA---------SDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFC 51
MKVI+KI AAA S NKVVFSFEFFPPKT+DGV NL ERMDRMV+H+PSFC
Sbjct: 1 MKVIDKIRAAAAAGDSNGGDSSSNNKVVFSFEFFPPKTDDGVDNLFERMDRMVSHNPSFC 60
Query: 52 DITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLA 111
DITWGAGGSTAD+TLDIA KMQN + VETMMHLTCTNMPVEKID ALETIKSNG+QNVLA
Sbjct: 61 DITWGAGGSTADLTLDIANKMQNIICVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLA 120
Query: 112 LRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATP 171
LRGDPPHGQDKFVQ++GG ACA DLVKHIR+K+GDYFGIT+AGYPEAHPD IGS+G AT
Sbjct: 121 LRGDPPHGQDKFVQIQGGLACALDLVKHIRSKYGDYFGITVAGYPEAHPDVIGSDGFATL 180
Query: 172 EDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKG 231
EDY DL YLK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPINNYKG
Sbjct: 181 EDYHKDLAYLKQKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPINNYKG 240
Query: 232 FIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNL 291
FIRM GFCKTKIPAE+ AALEPIKDNEEAV+AYGIHLGTEMCKKILAHG KTLHLYTLN+
Sbjct: 241 FIRMAGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNM 300
Query: 292 EKSALAILKNLGLIEETSI----PRTRPANAIQAKE 323
EKSALAIL NLGLIEE+ I P P N + KE
Sbjct: 301 EKSALAILMNLGLIEESKITRPLPWRPPTNVFRVKE 336
>B9STA4_RICCO (tr|B9STA4) Methylenetetrahydrofolate reductase OS=Ricinus communis
GN=RCOM_0364940 PE=3 SV=1
Length = 609
Score = 560 bits (1442), Expect = e-157, Method: Compositional matrix adjust.
Identities = 272/340 (80%), Positives = 294/340 (86%), Gaps = 17/340 (5%)
Query: 1 MKVIEKIHEA------------AASDPN-KVVFSFEFFPPKTEDGVVNLLERMDRMVAHS 47
MKVI+KI + A SD N KVVFSFEFFPPKTEDGV NL +RMDRMV+H+
Sbjct: 1 MKVIDKIKASVGASSHPHSNGGAISDSNDKVVFSFEFFPPKTEDGVDNLFDRMDRMVSHN 60
Query: 48 PSFCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQ 107
P+FCDITWGAGGSTAD+TLDIA KMQN + VETMMHLTCTNMPVEKID AL+TIKSNG+Q
Sbjct: 61 PTFCDITWGAGGSTADLTLDIANKMQNMICVETMMHLTCTNMPVEKIDHALQTIKSNGIQ 120
Query: 108 NVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNG 167
NVLALRGDPPHGQDKFVQVEGGFACA DLVKHIR+K+GDYFGIT+AGYPEAHPD I S+G
Sbjct: 121 NVLALRGDPPHGQDKFVQVEGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDMIESDG 180
Query: 168 LATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPIN 227
LATPE+YQ DL YLK KVDAGADLIITQLFYDTDIFLKF NDCRQIGI CPIVPGIMPIN
Sbjct: 181 LATPENYQRDLEYLKRKVDAGADLIITQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPIN 240
Query: 228 NYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLY 287
NYKGF+RMTGFCKTKIPAE+ AALEPIKDNEEAV+AYGIHLGTEMCKKI+AHG KTLHLY
Sbjct: 241 NYKGFLRMTGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKIMAHGIKTLHLY 300
Query: 288 TLNLEKSALAILKNLGLIEETSI----PRTRPANAIQAKE 323
TLN+EKSALAIL NLGLIEE+ I P P N + KE
Sbjct: 301 TLNMEKSALAILMNLGLIEESKISRPLPWRPPTNVFRVKE 340
>K4C2P8_SOLLC (tr|K4C2P8) Methylenetetrahydrofolate reductase OS=Solanum
lycopersicum GN=Solyc05g055730.2 PE=3 SV=1
Length = 596
Score = 559 bits (1441), Expect = e-157, Method: Compositional matrix adjust.
Identities = 266/327 (81%), Positives = 291/327 (88%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI E+ D +VVFSFEFFPPKTEDGV NL ERM+RMV+H+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+ +MQN V VETMMHLTCTNMPVEKID ALETIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKH+RAK+GDYFGIT+AGYPEAHPD I +NGLAT E Y+N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPANGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADL++TQLFYDTD FLKF +DCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLVVTQLFYDTDNFLKFVSDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T+IPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+A G KTLHLYTLN+EKSALAIL
Sbjct: 239 TRIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 299 NLGLIEESKISRLLPWRRPTNVFRIKE 325
>R0HRY0_9BRAS (tr|R0HRY0) Uncharacterized protein OS=Capsella rubella
GN=CARUB_v10022865mg PE=4 SV=1
Length = 594
Score = 558 bits (1439), Expect = e-157, Method: Compositional matrix adjust.
Identities = 262/327 (80%), Positives = 287/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI A D K FSFEFFPPKTEDGV NL ERMDRMVA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIQSLA--DEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA +MQN V VE+MMHLTCTNMPVEKID ALETI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGF CA DLV HIR+K+GDYFGIT+AGYPEAHPD IG NGLA+ E YQ+DL Y
Sbjct: 119 DKFVQVEGGFGCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD+FL+F NDCRQIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDVFLRFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCK ILAHG K+LHLYTLN+EKSALAIL
Sbjct: 239 TKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKTILAHGIKSLHLYTLNMEKSALAILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLG+I+E+ S+P RPAN + KE
Sbjct: 299 NLGMIDESKISRSLPWRRPANIFRTKE 325
>Q10BJ7_ORYSJ (tr|Q10BJ7) Methylenetetrahydrofolate reductase OS=Oryza sativa
subsp. japonica GN=Os03g0815200 PE=3 SV=1
Length = 594
Score = 558 bits (1438), Expect = e-157, Method: Compositional matrix adjust.
Identities = 270/327 (82%), Positives = 287/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA + VFSFE+FPPKTE+G+ NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAAD--GRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN V VETMMHLTCTNMPVEKIDDAL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPDAI S ATPE Y NDL Y
Sbjct: 119 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSAL IL
Sbjct: 239 TKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEE+ S+P P N + KE
Sbjct: 299 NLGLIEESKISRSLPWRPPTNVFRVKE 325
>A2XNC0_ORYSI (tr|A2XNC0) Methylenetetrahydrofolate reductase OS=Oryza sativa
subsp. indica GN=OsI_14054 PE=2 SV=1
Length = 594
Score = 558 bits (1438), Expect = e-157, Method: Compositional matrix adjust.
Identities = 270/327 (82%), Positives = 287/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA + VFSFE+FPPKTE+G+ NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAAD--GRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN V VETMMHLTCTNMPVEKIDDAL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPDAI S ATPE Y NDL Y
Sbjct: 119 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSAL IL
Sbjct: 239 TKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEE+ S+P P N + KE
Sbjct: 299 NLGLIEESKISRSLPWRPPTNVFRVKE 325
>F6I5I7_VITVI (tr|F6I5I7) Methylenetetrahydrofolate reductase OS=Vitis vinifera
GN=VIT_15s0024g00070 PE=2 SV=1
Length = 594
Score = 558 bits (1437), Expect = e-156, Method: Compositional matrix adjust.
Identities = 267/327 (81%), Positives = 293/327 (89%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI +AA ++ KVVFSFEFFPPKTEDGV NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIRDAA-TEEGKVVFSFEFFPPKTEDGVDNLFERMDRMVAHGPAFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+ KMQN + VETMMHLTCTNMPVEKID AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISNKMQNMICVETMMHLTCTNMPVEKIDHALDTIKSNGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQ++GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPD I NG+AT E YQ+DL Y
Sbjct: 120 DKFVQIQGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDVI-LNGVATSEAYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP+E+ AALEPIKDN+EAVKAYGIHLGTEMCKKILAHG KT+HLYTLN+EKSALAIL
Sbjct: 239 TKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTVHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 299 NLGLIEESKISRPFPWRRPTNVFRVKE 325
>A5ATB7_VITVI (tr|A5ATB7) Methylenetetrahydrofolate reductase OS=Vitis vinifera
GN=VITISV_016119 PE=1 SV=1
Length = 594
Score = 558 bits (1437), Expect = e-156, Method: Compositional matrix adjust.
Identities = 267/327 (81%), Positives = 292/327 (89%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI +AA + KVVFSFEFFPPKTEDGV NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIRDAATEE-GKVVFSFEFFPPKTEDGVDNLFERMDRMVAHGPAFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+ KMQN + VETMMHLTCTNMPVEKID AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISNKMQNMICVETMMHLTCTNMPVEKIDHALDTIKSNGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQ++GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPD I NG+AT E YQ+DL Y
Sbjct: 120 DKFVQIQGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDVI-LNGVATSEAYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP+E+ AALEPIKDN+EAVKAYGIHLGTEMCKKILAHG KT+HLYTLN+EKSALAIL
Sbjct: 239 TKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTVHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 299 NLGLIEESKISRPFPWRRPTNVFRVKE 325
>M1C552_SOLTU (tr|M1C552) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400023361 PE=3 SV=1
Length = 597
Score = 557 bits (1436), Expect = e-156, Method: Compositional matrix adjust.
Identities = 266/327 (81%), Positives = 290/327 (88%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI E+ D +VVFSFEFFPPKTEDGV NL ERM+RMV+H+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+ +MQN V VETMMHLTCTNMPVEKID ALETIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKH+RAK+GDYFGIT+AGYPEAHPD I + GLAT E Y+N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPATGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD FLKF +DCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIVTQLFYDTDNFLKFVSDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T+IPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+A G KTLHLYTLN+EKSALAIL
Sbjct: 239 TRIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 299 NLGLIEESKISRPLPWRRPTNVFRIKE 325
>Q10BJ6_ORYSJ (tr|Q10BJ6) Methylenetetrahydrofolate reductase OS=Oryza sativa
subsp. japonica GN=LOC_Os03g60090 PE=2 SV=1
Length = 573
Score = 557 bits (1436), Expect = e-156, Method: Compositional matrix adjust.
Identities = 270/327 (82%), Positives = 287/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA + VFSFE+FPPKTE+G+ NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAAD--GRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN V VETMMHLTCTNMPVEKIDDAL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPDAI S ATPE Y NDL Y
Sbjct: 119 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EKSAL IL
Sbjct: 239 TKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEE+ S+P P N + KE
Sbjct: 299 NLGLIEESKISRSLPWRPPTNVFRVKE 325
>D7LKW5_ARALL (tr|D7LKW5) Methylenetetrahydrofolate reductase OS=Arabidopsis
lyrata subsp. lyrata GN=ARALYDRAFT_483539 PE=3 SV=1
Length = 594
Score = 557 bits (1435), Expect = e-156, Method: Compositional matrix adjust.
Identities = 261/327 (79%), Positives = 287/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI A D K FSFEFFPPKTEDGV NL ERMDRMVA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIQSLA--DEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA +MQN V VE+MMHLTCTNMPVEKID ALETI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGF CA DLV HIR+K+GDYFGIT+AGYPEAHPD IG NGLA+ E YQ+DL Y
Sbjct: 119 DKFVQVEGGFGCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGADLI+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPINNY+GF+RMTGFCK
Sbjct: 179 LKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPINNYRGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCKK+LAHG K+LHLYTLN+EK ALAIL
Sbjct: 239 TKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKLALAILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLG+I+E+ S+P RPAN + KE
Sbjct: 299 NLGMIDESKISRSLPWRRPANVFRTKE 325
>M1C551_SOLTU (tr|M1C551) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400023361 PE=3 SV=1
Length = 460
Score = 555 bits (1430), Expect = e-156, Method: Compositional matrix adjust.
Identities = 266/327 (81%), Positives = 290/327 (88%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI E+ D +VVFSFEFFPPKTEDGV NL ERM+RMV+H+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+ +MQN V VETMMHLTCTNMPVEKID ALETIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKH+RAK+GDYFGIT+AGYPEAHPD I + GLAT E Y+N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPATGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD FLKF +DCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIVTQLFYDTDNFLKFVSDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T+IPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+A G KTLHLYTLN+EKSALAIL
Sbjct: 239 TRIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 299 NLGLIEESKISRPLPWRRPTNVFRIKE 325
>K4AMY6_SETIT (tr|K4AMY6) Methylenetetrahydrofolate reductase OS=Setaria italica
GN=Si040282m.g PE=3 SV=1
Length = 592
Score = 550 bits (1416), Expect = e-154, Method: Compositional matrix adjust.
Identities = 265/327 (81%), Positives = 283/327 (86%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI +AAA + FSFE+FPPKTE+GV NL ERMDRMVAH PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQQAAAD--GRTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA +MQN V VE+MMHLTCTNMPVEKID ALETIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIANRMQNMVCVESMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIRAK+GDYFGIT+AGYPEAHPDAI G ATPE Y NDL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATPEAYNNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF +DCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVDDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI ALEPIK+NEEAVK YG+HLGTEMCKKILA G KTLHLYTLN+EKSA+ ILK
Sbjct: 239 TKIPAEITDALEPIKENEEAVKEYGVHLGTEMCKKILASGIKTLHLYTLNMEKSAIEILK 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
LGLIEE + P P N + KE
Sbjct: 299 RLGLIEEFKVSRPLPWRPPTNVFRVKE 325
>M0TJL5_MUSAM (tr|M0TJL5) Methylenetetrahydrofolate reductase OS=Musa acuminata
subsp. malaccensis PE=3 SV=1
Length = 595
Score = 548 bits (1413), Expect = e-154, Method: Compositional matrix adjust.
Identities = 262/327 (80%), Positives = 286/327 (87%), Gaps = 5/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI A D + VFSFEFFPPKTE+GV NL ERMDRMVAH+P+FCDITWGAGGS
Sbjct: 1 MKVIDKIRAATEGD-GRTVFSFEFFPPKTEEGVENLFERMDRMVAHNPTFCDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA +MQN + VETMMHLTCTNMPVEKID AL+TIK+NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLDIANRMQNMICVETMMHLTCTNMPVEKIDHALDTIKANGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPD I +G AT E Y +DL Y
Sbjct: 120 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDMIQGDGGATLEAYNSDLAY 179
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTD FLKF NDCRQIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIITQLFYDTDNFLKFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP+EI AALEPIKDNEEAV+AYGIHLGTEMC+KILAHG KTLHLYTLN+EKSALAIL
Sbjct: 240 TKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILM 299
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
N GLIEE+ S+P RPAN + KE
Sbjct: 300 NFGLIEESKVSRSLPWRRPANIFRVKE 326
>C5WVY7_SORBI (tr|C5WVY7) Methylenetetrahydrofolate reductase OS=Sorghum bicolor
GN=Sb01g003700 PE=3 SV=1
Length = 593
Score = 548 bits (1411), Expect = e-153, Method: Compositional matrix adjust.
Identities = 265/327 (81%), Positives = 286/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAA + + FSFE+FPPKTE+GV NL ERMDRMVAH PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAGN--GRTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN V VETMMHLTCTNMPVEKID ALETIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPDAI G AT E Y NDL Y
Sbjct: 119 DKFVQVEGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATLEAYSNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP+EI AAL+PIKDNEEAVK YGIHLGTEMCKKILA G KTLHLYTLN++KSA+ IL
Sbjct: 239 TKIPSEITAALDPIKDNEEAVKQYGIHLGTEMCKKILATGIKTLHLYTLNMDKSAIGILM 298
Query: 301 NLGLIEETSIPR---TRPA-NAIQAKE 323
NLGLIEE+ + R RPA N + KE
Sbjct: 299 NLGLIEESKVSRPLPWRPATNVFRVKE 325
>M4CGR4_BRARP (tr|M4CGR4) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra003397 PE=3 SV=1
Length = 592
Score = 547 bits (1410), Expect = e-153, Method: Compositional matrix adjust.
Identities = 254/327 (77%), Positives = 286/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV++KI + ++ + FSFEFFPPKTEDGV NL ERMDR+V++ PSFCDITWGAGGS
Sbjct: 1 MKVVDKIK--SVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN + VETMMHLTCTNMPVEKID ALETI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLV HIR+K+GDYFGIT+AGYPEAHPD I +NGLATPE YQ+DL Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+ AALEPIKDNEEAVKAYGIH TEMCKKILAHG TLH+YTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNEEAVKAYGIHFATEMCKKILAHGITTLHIYTLNVDKSAIGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLI+E+ S+P RPAN + KE
Sbjct: 299 NLGLIDESKITRSLPWRRPANVFRTKE 325
>N1QRS8_AEGTA (tr|N1QRS8) Putative methylenetetrahydrofolate reductase
OS=Aegilops tauschii GN=F775_28470 PE=4 SV=1
Length = 594
Score = 546 bits (1406), Expect = e-153, Method: Compositional matrix adjust.
Identities = 262/327 (80%), Positives = 286/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA+ + VFSFE+FPPKTE+GV NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAAN--GRTVFSFEYFPPKTEEGVENLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TADVTLDIA +MQN V VETMMHLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGF+CA DLV+HI+AK+GDYFGIT+AGYPEAHP+ I AT E Y DL Y
Sbjct: 119 DKFVQVAGGFSCALDLVEHIKAKYGDYFGITVAGYPEAHPEVILGEEGATEEAYSKDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+I+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI AAL+PIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EK+ALAIL
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILM 298
Query: 301 NLGLIEETSIPRTR----PANAIQAKE 323
NLGLIEE+ + RT P N + KE
Sbjct: 299 NLGLIEESKLSRTLPWRPPTNVFRVKE 325
>I1GLP9_BRADI (tr|I1GLP9) Methylenetetrahydrofolate reductase OS=Brachypodium
distachyon GN=BRADI1G04140 PE=3 SV=1
Length = 594
Score = 546 bits (1406), Expect = e-153, Method: Compositional matrix adjust.
Identities = 262/327 (80%), Positives = 285/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA+ + VFSFE+FPP+TE+GV NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAAN--GRTVFSFEYFPPRTEEGVENLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TADVTLDIA +MQN V VETMMHLTCTNMPVEKID AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDSALDTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGF+CA DLV+HI+AK+GDYFGIT+AGYPEAHP+ I AT E Y NDL Y
Sbjct: 119 DKFVQVAGGFSCALDLVQHIKAKYGDYFGITVAGYPEAHPEVILGEEGATEEAYSNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD+FLKF NDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDMFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI AAL+PIKDNEEAVKAYGIHLGTEMCKKILA G TLHLYTLN+EK+ALAIL
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGINTLHLYTLNMEKTALAILM 298
Query: 301 NLGLIEETSIPRTR----PANAIQAKE 323
NLGLIEE+ + RT P N + KE
Sbjct: 299 NLGLIEESKLSRTLPWRPPTNVFRVKE 325
>M4F9A1_BRARP (tr|M4F9A1) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra037664 PE=3 SV=1
Length = 595
Score = 545 bits (1404), Expect = e-153, Method: Compositional matrix adjust.
Identities = 253/327 (77%), Positives = 286/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI + +D K FSFEFFPP+TEDGV NL ERMDR+VA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIK--SWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDI +MQN V VE+MMHLTCTNMPVEKID ALETI+SNG+QNVLALRGDPPHG+
Sbjct: 59 TADLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGE 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+KFVQVEGGF CA DLV HIR+K+GDYFGI ++GYPEAHPD IG NGLA+ E YQ+DL Y
Sbjct: 119 NKFVQVEGGFGCALDLVNHIRSKYGDYFGIAVSGYPEAHPDVIGENGLASKEAYQSDLEY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLF+DTD+ LKF NDCRQIGI CPIVPGIMPINNYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFFDTDMLLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMIGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+MAALEPI+DNEEAVKAYGIHLGTEMCKKILAHG K+LHLYTLN+EKSAL+IL
Sbjct: 239 TKIPAEVMAALEPIQDNEEAVKAYGIHLGTEMCKKILAHGIKSLHLYTLNMEKSALSILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLG+IEE+ S+P RPAN + KE
Sbjct: 299 NLGMIEESKISRSLPWRRPANVFRIKE 325
>J3LU35_ORYBR (tr|J3LU35) Methylenetetrahydrofolate reductase OS=Oryza
brachyantha GN=OB03G45610 PE=3 SV=1
Length = 594
Score = 545 bits (1403), Expect = e-152, Method: Compositional matrix adjust.
Identities = 262/327 (80%), Positives = 285/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA + VFSFE+FPPKTE+G+ NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIREAAAD--GRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN V VETMMHLTCTNMPVE ID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVENIDEALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGFACA DLV+HI+AK+GDYFGIT+AGYPEAHP+ I S AT E Y NDL Y
Sbjct: 119 DKFVQVSGGFACALDLVRHIKAKYGDYFGITVAGYPEAHPEVIHSAEGATLEAYSNDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAEI AAL+PIKDNEEAVKAYGIHLGTEMCKK+LA G KTLHLYTLN+EKSAL IL+
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKVLASGIKTLHLYTLNMEKSALGILQ 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLIEE+ S+P P N + KE
Sbjct: 299 NLGLIEESKVARSLPWRPPTNVFRVKE 325
>D7LWJ5_ARALL (tr|D7LWJ5) Methylenetetrahydrofolate reductase OS=Arabidopsis
lyrata subsp. lyrata GN=ARALYDRAFT_486463 PE=3 SV=1
Length = 592
Score = 544 bits (1402), Expect = e-152, Method: Compositional matrix adjust.
Identities = 252/327 (77%), Positives = 286/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV++KI + ++ + FSFEFFPPKTEDGV NL ERMDR+V++ P+FCDITWGAGGS
Sbjct: 1 MKVVDKIK--SVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN + VETMMHLTCTNMP+EKID ALETI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLV HIR+K+GDYFGIT+AGYPEAHPD I +NGLATPE YQ+DL Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+ AALEPIKDN+EAVKAYGIH TEMCKKILAHG TLHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITTLHLYTLNVDKSAIGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLI+E+ S+P RPAN + KE
Sbjct: 299 NLGLIDESKISRSLPWRRPANVFRTKE 325
>R0FNP9_9BRAS (tr|R0FNP9) Uncharacterized protein OS=Capsella rubella
GN=CARUB_v10016903mg PE=4 SV=1
Length = 592
Score = 543 bits (1400), Expect = e-152, Method: Compositional matrix adjust.
Identities = 253/327 (77%), Positives = 284/327 (86%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV++KI + ++ K FSFEFFPPKTEDGV NL ERMDR+V++ P+FCDITWGAGGS
Sbjct: 1 MKVVDKIK--SVTEQGKTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN + VETMMHLTCTNMPVEKID ALETI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLV HIR K+GDYFGIT+AGYPEAHPD I +NGLATPE YQ+DL Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRTKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+ AALEPIKDN+EAVKAYGIH TEMCKKILAHG TLHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITTLHLYTLNVDKSAIGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLI+E+ S+P RPAN + E
Sbjct: 299 NLGLIDESKISRSLPWRRPANVFRISE 325
>B8LKP0_PICSI (tr|B8LKP0) Methylenetetrahydrofolate reductase OS=Picea sitchensis
PE=1 SV=1
Length = 594
Score = 543 bits (1400), Expect = e-152, Method: Compositional matrix adjust.
Identities = 264/327 (80%), Positives = 283/327 (86%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI A KVVFSFEFFPPKTE+GV NL +RMDRMV H PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQNAEKE--GKVVFSFEFFPPKTEEGVENLFDRMDRMVEHQPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDI+ KMQN + VE+MMHLTCTNMPVEKID AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDISNKMQNMICVESMMHLTCTNMPVEKIDHALATIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIR+K+GDYFGIT+AGYPEAHPD I + AT EDYQ DL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDMIKNEVGATEEDYQKDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIITQLFYDTDI+LKF NDCRQIGI CPIVPGIMPINNYKGFIRM GFCK
Sbjct: 179 LKLKVDAGADLIITQLFYDTDIYLKFVNDCRQIGIKCPIVPGIMPINNYKGFIRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP+EI AALEPIKDNEEAV+AYGIHLGTEMCKKILAHG KTLHLYTLN+EKSAL IL
Sbjct: 239 TKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALGILA 298
Query: 301 NLGLIEETSIPR---TRPA-NAIQAKE 323
NLGLI+ T I R RPA N ++ KE
Sbjct: 299 NLGLIDMTKIRRPLPWRPATNVLRTKE 325
>M4CTF4_BRARP (tr|M4CTF4) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra007497 PE=3 SV=1
Length = 592
Score = 542 bits (1397), Expect = e-152, Method: Compositional matrix adjust.
Identities = 251/327 (76%), Positives = 287/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV++KI +A++ + FSFEFFPPKTEDGV NL ERMDR+V++ PSFCDITWGAGGS
Sbjct: 1 MKVVDKIK--SATEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN + VETMMHLTCTNMPVEKID ALETI+SNG+QNVLALRGDPPHG+
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGE 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLV H+R+K+GDYFGIT+AGYPEAHPD I ++GLATPE YQ+DL Y
Sbjct: 119 DKFVQVEGGFACALDLVNHVRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCR+IGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRKIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+ AALEPIKDNEEAVKA+GIH TEMCKKILAHG TLHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHLYTLNMDKSAIGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLI+E+ S+P RPAN + KE
Sbjct: 299 NLGLIDESKITRSLPWRRPANVFRTKE 325
>G3C900_PINPS (tr|G3C900) Methylenetetrahydrofolate reductase OS=Pinus pinaster
GN=mthfr PE=2 SV=1
Length = 594
Score = 540 bits (1390), Expect = e-151, Method: Compositional matrix adjust.
Identities = 262/327 (80%), Positives = 284/327 (86%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEK+ A KVVFSFEFFPPKTE GV NL +RMD+MV H PSFCDITWGAGGS
Sbjct: 1 MKVIEKLQNAEKE--GKVVFSFEFFPPKTEGGVENLFDRMDQMVEHQPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDI+ KMQN + VETMMHLTCTNMPVEKID AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDISNKMQNMICVETMMHLTCTNMPVEKIDHALTTIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKHIR+K+GDYFGIT+AGYPEAHPD I ++ AT EDYQ DL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDMIKNDMGATEEDYQKDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIITQLFYDTDI+LKF NDCRQIGI CPIVPGIMPIN Y GFIRM GFCK
Sbjct: 179 LKSKVDAGADLIITQLFYDTDIYLKFVNDCRQIGIKCPIVPGIMPINTYGGFIRMVGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIP+EI AALEPIKDNEEAV+AYGIHLGTEMCKKILAHG KTLHLYTLN++KSALAIL
Sbjct: 239 TKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMDKSALAILG 298
Query: 301 NLGLIEETSIPRT---RPA-NAIQAKE 323
NLGLI+ T I R+ RPA N ++ KE
Sbjct: 299 NLGLIDMTKIRRSLPWRPATNVLRTKE 325
>F4JAK1_ARATH (tr|F4JAK1) Methylenetetrahydrofolate reductase OS=Arabidopsis
thaliana GN=MTHFR1 PE=2 SV=1
Length = 407
Score = 538 bits (1387), Expect = e-151, Method: Compositional matrix adjust.
Identities = 250/327 (76%), Positives = 286/327 (87%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV++KI + ++ + FSFEFFPPKTEDGV NL ERMDR+V++ P+FCDITWGAGGS
Sbjct: 1 MKVVDKIK--SVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA +MQN + VETMMHLTCTNMP+EKID ALETI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLV HIR+K+GDYFGIT+AGYPEAHPD I ++GLATPE YQ+DL Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKF NDCRQIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+ AALEPIKDN+EAVKAYGIH TEMCKKILAHG +LHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILM 298
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLGLI+E+ S+P RPAN + KE
Sbjct: 299 NLGLIDESKISRSLPWRRPANVFRTKE 325
>M7ZYT1_TRIUA (tr|M7ZYT1) Putative methylenetetrahydrofolate reductase
OS=Triticum urartu GN=TRIUR3_34128 PE=4 SV=1
Length = 586
Score = 527 bits (1358), Expect = e-147, Method: Compositional matrix adjust.
Identities = 250/316 (79%), Positives = 274/316 (86%), Gaps = 4/316 (1%)
Query: 12 ASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKK 71
A+ + V FE+FPPKTE+GV NL ERMDRMVAH P+FCDITWGAGGSTADVTLDIA +
Sbjct: 2 AASKGRTVLYFEYFPPKTEEGVENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANR 61
Query: 72 MQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFA 131
MQN V VETMMHLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQDKFVQV GGF+
Sbjct: 62 MQNMVCVETMMHLTCTNMPVEKIDNALDTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFS 121
Query: 132 CARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADL 191
CA DLV+HI+AK+GDYFGIT+AGYPEAHP+ I AT E Y DL YLK KVDAGAD+
Sbjct: 122 CALDLVEHIKAKYGDYFGITVAGYPEAHPEVILGEEGATEEAYSKDLAYLKRKVDAGADV 181
Query: 192 IITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAAL 251
I+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCKTKIPAEI AAL
Sbjct: 182 IVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAAL 241
Query: 252 EPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
+PIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTLN+EK+ALAIL NLGLIEE+ +
Sbjct: 242 DPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLS 301
Query: 312 RTR----PANAIQAKE 323
RT P N + KE
Sbjct: 302 RTLPWRPPTNVFRVKE 317
>M4CKS5_BRARP (tr|M4CKS5) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra004810 PE=3 SV=1
Length = 556
Score = 518 bits (1334), Expect = e-144, Method: Compositional matrix adjust.
Identities = 248/327 (75%), Positives = 275/327 (84%), Gaps = 18/327 (5%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI A D K FSFEFFPPKTEDGV NL ERMDRMVA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIQSLA--DEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA +MQN V VE+MMHLTCTNMPVEKID ALETI++NG+QNVLALRGDPPHG
Sbjct: 59 TADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRANGIQNVLALRGDPPHGH 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFV+VEGGF CA DLV H+R K+ EAHPD IG NGLA+ E YQ+DL Y
Sbjct: 119 DKFVKVEGGFGCALDLVNHVRGKY------------EAHPDVIGENGLASDEAYQSDLEY 166
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD+FLKF NDCRQIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 167 LKRKVDAGADLIVTQLFYDTDVFLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMTGFCK 226
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPAE+MAALEPI+DNEEAVKAYGIHLGTEMC+KILAHG K+LHLYTLN+EKSALAIL
Sbjct: 227 TKIPAEVMAALEPIQDNEEAVKAYGIHLGTEMCRKILAHGTKSLHLYTLNMEKSALAILM 286
Query: 301 NLGLIEET----SIPRTRPANAIQAKE 323
NLG+I+E+ S+P RPAN + KE
Sbjct: 287 NLGMIDESKISRSLPWRRPANVFRTKE 313
>A9U4S7_PHYPA (tr|A9U4S7) Methylenetetrahydrofolate reductase OS=Physcomitrella
patens subsp. patens GN=PHYPADRAFT_228287 PE=3 SV=1
Length = 592
Score = 510 bits (1313), Expect = e-142, Method: Compositional matrix adjust.
Identities = 239/327 (73%), Positives = 275/327 (84%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI+ A VVFSFEFFPPKTE+GV NL +RMDRMV H P+FCDITWGAGGS
Sbjct: 1 MKVIDKINNGLAG--GNVVFSFEFFPPKTEEGVENLFDRMDRMVMHQPAFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+ VTLDIA KMQN + VETMMHLTCTNM VE +D AL+++KSNG+QN+LALRGDPPHGQ
Sbjct: 59 TSAVTLDIANKMQNMICVETMMHLTCTNMLVETLDGALDSVKSNGIQNILALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFV +EGGF+CA DLV+HIRAK+GDYFGIT+AGYPEAHP+ IG +G+A+ E YQ DL Y
Sbjct: 119 DKFVTIEGGFSCALDLVRHIRAKYGDYFGITVAGYPEAHPEVIGEDGVASEEAYQKDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAG ++IITQLFYDTDIFLKF NDCRQIGI PIVPGIMPI NYKGF+RMT CK
Sbjct: 179 LKEKCDAGGEVIITQLFYDTDIFLKFVNDCRQIGIKVPIVPGIMPIQNYKGFLRMTTLCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TK+PAEIMAALEPIKDN+EAV+AYGIHLGTEMCKKILAH +TLHLY+LNLEKS L IL+
Sbjct: 239 TKVPAEIMAALEPIKDNDEAVRAYGIHLGTEMCKKILAHDIRTLHLYSLNLEKSVLGILQ 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLI+ + + P P N+ + KE
Sbjct: 299 NLGLIDFSRVSRPLPWRPPTNSKRTKE 325
>M0YZ59_HORVD (tr|M0YZ59) Methylenetetrahydrofolate reductase OS=Hordeum vulgare
var. distichum PE=3 SV=1
Length = 287
Score = 506 bits (1303), Expect = e-141, Method: Compositional matrix adjust.
Identities = 241/289 (83%), Positives = 260/289 (89%), Gaps = 2/289 (0%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI EAAA+ + VFSFE+FPPKTE+GV NL ERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAAN--GRTVFSFEYFPPKTEEGVENLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TADVTLDIA +MQN V VETMMHLTCTNMPVEKID+AL+TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQV GGF+CA DLV+HIRAK+GDYFGIT+AGYPEAHP+ I AT E Y DL Y
Sbjct: 119 DKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+I+TQLFYDTDIFLKF NDCRQIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTL 289
TKIPAEI AAL+PIKDNEEAVKAYGIHLGTEMCKKILA G KTLHLYTL
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTL 287
>A6XMY8_TRIMO (tr|A6XMY8) Methylenetetrahydrofolate reductase OS=Triticum
monococcum PE=1 SV=1
Length = 582
Score = 505 bits (1300), Expect = e-140, Method: Compositional matrix adjust.
Identities = 240/297 (80%), Positives = 262/297 (88%), Gaps = 4/297 (1%)
Query: 31 DGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMP 90
+GV NL ERMDRMVAH P+FCDITWGAGGSTADVTLDIA +MQN V VETMMHLTCTNMP
Sbjct: 17 EGVENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQNMVCVETMMHLTCTNMP 76
Query: 91 VEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGI 150
VEKID+AL+TIKSNG+QNVLALRGDPPHGQDKFVQV GGF+CA DLV+HI+AK+GDYFGI
Sbjct: 77 VEKIDNALDTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFSCALDLVEHIKAKYGDYFGI 136
Query: 151 TIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDC 210
T+AGYPEAHP+ I AT E Y+ DL YLK KVDAGAD+I+TQLFYDTDIFLKF NDC
Sbjct: 137 TVAGYPEAHPEVILGEEGATEEAYRKDLAYLKRKVDAGADVIVTQLFYDTDIFLKFVNDC 196
Query: 211 RQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGT 270
RQIGITCPIVPGIMPINNYKGF+RMTGFCKTKIPAEI AAL+PIKDNEEAVKAYGIHLGT
Sbjct: 197 RQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGT 256
Query: 271 EMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTR----PANAIQAKE 323
EMCKKILA G KTLHLYTLN+EK+ALAIL NLGLIEE+ + RT P N + KE
Sbjct: 257 EMCKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKE 313
>A9RW65_PHYPA (tr|A9RW65) Methylenetetrahydrofolate reductase OS=Physcomitrella
patens subsp. patens GN=PHYPADRAFT_161370 PE=3 SV=1
Length = 594
Score = 501 bits (1291), Expect = e-140, Method: Compositional matrix adjust.
Identities = 232/327 (70%), Positives = 273/327 (83%), Gaps = 6/327 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI+ A VVFSFEFFPPKTE+GV NL +RMDRMV H P+FCDITWGAGGS
Sbjct: 1 MKVIDKINNGLAG--GNVVFSFEFFPPKTEEGVENLFDRMDRMVRHQPAFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+ +TLDIA KMQN + VETMMHLTCTNM VE +D+AL+ +KSNG+QN+LALRGDPPHGQ
Sbjct: 59 TSAITLDIANKMQNMICVETMMHLTCTNMLVETLDNALDNVKSNGIQNILALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFV ++GGF+CA DLV+HI+ K+GDYFGIT+AGYPEAHPD IG +G+A+ E Y+ DL Y
Sbjct: 119 DKFVTIDGGFSCALDLVRHIKDKYGDYFGITVAGYPEAHPDVIGEDGIASEEAYKKDLAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAG ++I+TQLFYDTDIFLKF NDCRQIGI P+VPGIMPI NYKGF+RMT CK
Sbjct: 179 LKEKCDAGGEVIVTQLFYDTDIFLKFVNDCRQIGIKAPVVPGIMPIQNYKGFLRMTSLCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TK+PAEIMA LEPIKDN+EAV+AYGIHLGTEMCKKILAH +TLHLY+LNLEKS L IL+
Sbjct: 239 TKVPAEIMATLEPIKDNDEAVRAYGIHLGTEMCKKILAHDIRTLHLYSLNLEKSVLGILQ 298
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLI+ + + P P N+ + KE
Sbjct: 299 NLGLIDFSKVTRPLPWRPPTNSKRTKE 325
>D8QNN7_SELML (tr|D8QNN7) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_140106 PE=3 SV=1
Length = 594
Score = 498 bits (1283), Expect = e-139, Method: Compositional matrix adjust.
Identities = 229/327 (70%), Positives = 273/327 (83%), Gaps = 7/327 (2%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M++++KI +A N+ +FSFE+FPPKT++GV NL ERMDRMV H P+FCDITWGAGGS
Sbjct: 1 MRIVDKIKDAQRE--NRTIFSFEYFPPKTDEGVENLFERMDRMVMHQPAFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+TL+I KMQN + VE+MMHLTCTNMPV K+D ALE +K+NG+QN+LALRGDPPHGQ
Sbjct: 59 TSDLTLEIVNKMQNMICVESMMHLTCTNMPVSKLDFALENVKANGVQNILALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVE GF+CA DLVKHIR K+G YFGIT+AGYPEAHPD I S AT E Y+ DL Y
Sbjct: 119 DKFVQVEDGFSCALDLVKHIRKKYGGYFGITVAGYPEAHPDVI-SGDAATQEAYEKDLAY 177
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG D +ITQLFYDTD+FL+F NDCR+IGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 178 LKEKVDAGGDFVITQLFYDTDLFLRFVNDCREIGITCPIVPGIMPINNYKGFLRMTGFCK 237
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T IPA+I AALEPIKDN+EAV+++G+HLGTEMCKKILA G +HLYTLN+EKSA+AIL+
Sbjct: 238 TNIPADITAALEPIKDNDEAVRSFGVHLGTEMCKKILASGINAVHLYTLNMEKSAIAILQ 297
Query: 301 NLGLIE----ETSIPRTRPANAIQAKE 323
NLGLI+ S+P P N + +E
Sbjct: 298 NLGLIDISQVRRSLPWRPPTNVRRTRE 324
>D8RDX1_SELML (tr|D8RDX1) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_146279 PE=3 SV=1
Length = 594
Score = 498 bits (1282), Expect = e-138, Method: Compositional matrix adjust.
Identities = 230/327 (70%), Positives = 273/327 (83%), Gaps = 7/327 (2%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M++++KI +A N+ +FSFE+FPPKT++GV NL ERMDRMV H P+FCDITWGAGGS
Sbjct: 1 MRIVDKIKDAQRE--NRTIFSFEYFPPKTDEGVENLFERMDRMVMHQPAFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+TL+I KMQN + VE+MMHLTCTNMPV K+D AL +K+NG+QN+LALRGDPPHGQ
Sbjct: 59 TSDLTLEIVNKMQNMICVESMMHLTCTNMPVSKLDFALGNVKANGVQNILALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVE GF+CA DLVKHIR K+G YFGIT+AGYPEAHPD I S AT E Y+ DL Y
Sbjct: 119 DKFVQVEDGFSCALDLVKHIRKKYGGYFGITVAGYPEAHPDVI-SGDAATQEAYEKDLAY 177
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG D IITQLFYDTD+FL+F NDCR+IGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 178 LKEKVDAGGDFIITQLFYDTDLFLRFVNDCREIGITCPIVPGIMPINNYKGFLRMTGFCK 237
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TKIPA+I AALEPIKDN+EAV+++G+HLGTEMCKKILA G +HLYTLN+EKSA+AIL+
Sbjct: 238 TKIPADITAALEPIKDNDEAVRSFGVHLGTEMCKKILASGINAVHLYTLNMEKSAIAILQ 297
Query: 301 NLGLIE----ETSIPRTRPANAIQAKE 323
NLGLI+ S+P P N + +E
Sbjct: 298 NLGLIDISQVRRSLPWRPPTNVRRTRE 324
>M0RR35_MUSAM (tr|M0RR35) Methylenetetrahydrofolate reductase OS=Musa acuminata
subsp. malaccensis PE=3 SV=1
Length = 554
Score = 496 bits (1276), Expect = e-138, Method: Compositional matrix adjust.
Identities = 234/285 (82%), Positives = 256/285 (89%), Gaps = 4/285 (1%)
Query: 43 MVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIK 102
MVAH+P+FCDITWGAGGSTAD+TLDIA +MQN + VETMMHLTCTNMPVEKID AL+TIK
Sbjct: 1 MVAHNPNFCDITWGAGGSTADLTLDIANRMQNMICVETMMHLTCTNMPVEKIDHALDTIK 60
Query: 103 SNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDA 162
+NG+QNVLALRGDPPHGQDKFVQV GGFACA DLV+HIRAK+GDYFGIT+AGYPEAHPD
Sbjct: 61 ANGIQNVLALRGDPPHGQDKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDM 120
Query: 163 IGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPG 222
I +G AT E Y NDL YLK KVDAGADLIITQLFYDTDIFLKF NDCRQIGITCPIVPG
Sbjct: 121 IQGDGGATQEAYNNDLAYLKRKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPG 180
Query: 223 IMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFK 282
IMPINNYKGF+RMTGFCKTKIP EI AAL+PIKDNE+AV+AYG+HLGTEMCKKIL+HG K
Sbjct: 181 IMPINNYKGFLRMTGFCKTKIPPEITAALDPIKDNEDAVRAYGVHLGTEMCKKILSHGIK 240
Query: 283 TLHLYTLNLEKSALAILKNLGLIEET----SIPRTRPANAIQAKE 323
TLHLYTLN+EKSALAIL NLGLIEE+ S+P RPAN + KE
Sbjct: 241 TLHLYTLNMEKSALAILMNLGLIEESKVSRSLPWRRPANVFRVKE 285
>M1C550_SOLTU (tr|M1C550) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400023361 PE=3 SV=1
Length = 561
Score = 464 bits (1195), Expect = e-128, Method: Compositional matrix adjust.
Identities = 234/327 (71%), Positives = 255/327 (77%), Gaps = 42/327 (12%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVIEKI E+ D +VVFSFEFFPPKTEDGV NL ERM+RMV+H+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+ +MQN V VETMMHLTCTNMPVEKID ALETIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKFVQVEGGFACA DLVKH+RAK+GDYFGIT+AGYPEAHPD I + GLAT E Y+N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPATGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD FLKF
Sbjct: 179 LKQKVDAGADLIVTQLFYDTDNFLKF---------------------------------- 204
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+A G KTLHLYTLN+EKSALAIL
Sbjct: 205 --IPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 262
Query: 301 NLGLIEETSI----PRTRPANAIQAKE 323
NLGLIEE+ I P RP N + KE
Sbjct: 263 NLGLIEESKISRPLPWRRPTNVFRIKE 289
>I0YN51_9CHLO (tr|I0YN51) Methylenetetrahydrofolate reductase OS=Coccomyxa
subellipsoidea C-169 GN=COCSUDRAFT_30887 PE=3 SV=1
Length = 342
Score = 433 bits (1113), Expect = e-119, Method: Compositional matrix adjust.
Identities = 198/313 (63%), Positives = 249/313 (79%), Gaps = 2/313 (0%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+++K++E+ + K FSFEFFPP+T++GV NL R RM A+ P+FCDITWGAGG+
Sbjct: 1 MKIVDKMNESIKA--GKTFFSFEFFPPRTDEGVENLYSRQHRMAAYGPTFCDITWGAGGT 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TAD+TLDIA KMQNTVGVETMMHLTCTNMP ++++AL+ +KS G+QN+LALRGDPP GQ
Sbjct: 59 TADLTLDIAAKMQNTVGVETMMHLTCTNMPESQLENALDKVKSYGIQNILALRGDPPKGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ F VEGGF+CA DLVK+I+AK+GD+FGIT+AGYPE HPDAI SN + Y DL Y
Sbjct: 119 ETFTVVEGGFSCALDLVKYIKAKYGDFFGITVAGYPEGHPDAIVSNPEEMDKAYWADLHY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG ++I+TQLFYD D F KF D R +GITCPI+PGIMPI Y GF RMT FCK
Sbjct: 179 LKEKIDAGGEIIVTQLFYDVDRFFKFVQDVRSLGITCPIIPGIMPIMTYGGFKRMTSFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T IP+EI LE IKDN+EAVKAYGI LGT+MC+++L G LH+YTLNLE ++++IL+
Sbjct: 239 TAIPSEISEHLEKIKDNDEAVKAYGIELGTQMCRRLLEAGTPGLHMYTLNLENASVSILQ 298
Query: 301 NLGLIEETSIPRT 313
NLGLIE++ + T
Sbjct: 299 NLGLIEKSQVSAT 311
>D8U7H4_VOLCA (tr|D8U7H4) Methylenetetrahydrofolate reductase OS=Volvox carteri
GN=VOLCADRAFT_95450 PE=3 SV=1
Length = 595
Score = 431 bits (1109), Expect = e-118, Method: Compositional matrix adjust.
Identities = 200/315 (63%), Positives = 245/315 (77%), Gaps = 2/315 (0%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I KI++ + FSFEFFPP+TE+GV NL ER+DRMVA+ P FCDITWGAGGS
Sbjct: 1 MKIINKINQKLKD--GQTFFSFEFFPPRTEEGVENLFERLDRMVAYGPIFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TADVTLDIA +MQN V VETMMHLTCTNMPVEK++ AL +K G+ N+LALRGDPP GQ
Sbjct: 59 TADVTLDIATRMQNQVCVETMMHLTCTNMPVEKLESALLEVKKAGVHNILALRGDPPKGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DKF VEGGF+CA DLVK+IR + GD FGI +AGYPEAHPD I + ++Y D+ Y
Sbjct: 119 DKFEAVEGGFSCALDLVKYIRKEFGDLFGICVAGYPEAHPDGIVDDPELMEQNYWADIAY 178
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV+AG +LIITQLFY+TDIFLKF DCR +GIT PI+PGIMPI Y GF RMTGFCK
Sbjct: 179 LKQKVEAGGELIITQLFYNTDIFLKFVEDCRSVGITVPILPGIMPIMTYGGFKRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TK+PA+I+ A+E IKDN+EAVK +G+ LG MC+++L G +H+YTLNLE+SA+ IL+
Sbjct: 239 TKVPADILEAVEAIKDNDEAVKNFGVDLGVRMCRRLLDAGVPGVHMYTLNLERSAVGILE 298
Query: 301 NLGLIEETSIPRTRP 315
LGLI+ +P+ P
Sbjct: 299 RLGLIDTARVPKPLP 313
>D8S976_SELML (tr|D8S976) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_177964 PE=3 SV=1
Length = 322
Score = 418 bits (1075), Expect = e-114, Method: Compositional matrix adjust.
Identities = 198/324 (61%), Positives = 252/324 (77%), Gaps = 6/324 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+++ EA + D K+V+SFEF PP+T G+ LL+ +DR+V PSFCDITW A S
Sbjct: 1 MKIIDRVKEAWSED--KIVYSFEFMPPRTPKGMKLLLDSLDRIVMFQPSFCDITWRA--S 56
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
++++TL+IA+KM+ G+ETMMHLTC E+ID AL+ ++S+G++N+LALRGDPP G+
Sbjct: 57 SSEMTLEIARKMKTMFGLETMMHLTCVGSTPERIDSALDFVRSHGVENILALRGDPPEGE 116
Query: 121 DKF-VQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ V G +CA DLV HIR +G FGI +AGYPEAHPD I ++G AT EDYQ DL
Sbjct: 117 EALDVAGSGDLSCALDLVSHIRETYGSSFGIVVAGYPEAHPDVIQADGSATEEDYQKDLA 176
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGADLII+QLFYDTDIFLKF NDCRQIGITCPIVPGI+PIN+Y+ F+RMT C
Sbjct: 177 YLKKKVDAGADLIISQLFYDTDIFLKFVNDCRQIGITCPIVPGILPINDYRKFLRMTTLC 236
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
KTK+PA++ AL+ IKD+ AV+ YGIHLGTEMCKKILAHG K LHLYTLN EK+A+ IL
Sbjct: 237 KTKVPADVRDALQSIKDDPVAVRKYGIHLGTEMCKKILAHGIKALHLYTLNSEKTAIEIL 296
Query: 300 KNLGLIEETSIPRTRPANAIQAKE 323
KNLGL++ + + R P +A Q K+
Sbjct: 297 KNLGLVDVSKVARPLPPSA-QCKQ 319
>D8SVM0_SELML (tr|D8SVM0) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_126029 PE=3 SV=1
Length = 322
Score = 414 bits (1065), Expect = e-113, Method: Compositional matrix adjust.
Identities = 196/324 (60%), Positives = 251/324 (77%), Gaps = 6/324 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+++ EA + D K+V+SFEF PP+T G+ LL+ +DR+V PSFCDITW A S
Sbjct: 1 MKIIDRVKEAWSED--KIVYSFEFMPPRTPKGMKLLLDSLDRIVMFQPSFCDITWRA--S 56
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
++++TL+IA+KM+ G+ETMMHLTC E+ID AL+ ++S+G++N+LALRGDPP G+
Sbjct: 57 SSEMTLEIARKMKTMFGLETMMHLTCVGSTPERIDSALDFVRSHGVENILALRGDPPEGE 116
Query: 121 DKF-VQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ V +CA DLV HIR +G FGI +AGYPEAHPD I ++G AT EDYQ DL
Sbjct: 117 EALDVAGSDDLSCALDLVSHIRETYGSSFGIVVAGYPEAHPDVIQADGSATEEDYQKDLA 176
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGADLII+QLFYDTDIFLKF NDCRQIGITCPIVPGI+PIN+Y+ F+RMT C
Sbjct: 177 YLKKKVDAGADLIISQLFYDTDIFLKFVNDCRQIGITCPIVPGILPINDYRKFLRMTTLC 236
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
+TK+PA++ AL+ IKD+ AV+ YGIHLGTEMCKKILAHG K LHLYTLN EK+A+ IL
Sbjct: 237 RTKVPADVRDALQSIKDDPVAVRKYGIHLGTEMCKKILAHGIKALHLYTLNSEKTAIEIL 296
Query: 300 KNLGLIEETSIPRTRPANAIQAKE 323
KNLGL++ + + R P +A Q K+
Sbjct: 297 KNLGLVDVSKVARPLPPSA-QCKQ 319
>A8IAY6_CHLRE (tr|A8IAY6) Methylenetetrahydrofolate reductase OS=Chlamydomonas
reinhardtii GN=CHLREDRAFT_111330 PE=1 SV=1
Length = 594
Score = 405 bits (1042), Expect = e-111, Method: Compositional matrix adjust.
Identities = 195/322 (60%), Positives = 237/322 (73%), Gaps = 9/322 (2%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I K+ E + FSFEFFPP+TE+GV NL ER+DRMVA+ P FCDITWGAGGS
Sbjct: 1 MKLIHKVEEKMKK--GETFFSFEFFPPRTEEGVENLFERLDRMVAYGPVFCDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TADVTLDIA +MQN + VETMMHLTCTNMP EK++ AL +K G+QN+LALRGDPP
Sbjct: 59 TADVTLDIATRMQNLICVETMMHLTCTNMPEEKLESALHEVKKMGVQNILALRGDPPK-- 116
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
V+V G C V ++HGDYFGI +AGYPEAHPD I + ++Y D+ Y
Sbjct: 117 ---VRV-GACVCVTSAVHQDESQHGDYFGICVAGYPEAHPDGIVDDPEQMKKNYWADIAY 172
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG D+I+TQLFYD D+FL+F DCR +GITCPI+PGIMPI Y GF RMTGFCK
Sbjct: 173 LKQKVDAGGDMIVTQLFYDVDVFLQFVKDCRSVGITCPILPGIMPIMTYGGFKRMTGFCK 232
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAIL 299
TK+PAEI ALE IKDN+EAVKAYGI LG MC+++LA G +H+YTLNLEKSA+AIL
Sbjct: 233 TKVPAEISDALEAIKDNDEAVKAYGIDLGVRMCRQLLASGEVPGVHMYTLNLEKSAVAIL 292
Query: 300 KNLGLIEETSIPRTRPANAIQA 321
+ LGL++ + + R P + A
Sbjct: 293 EQLGLVDTSRVQRPLPWRHVPA 314
>J7MPV6_9CHLO (tr|J7MPV6) Methylenetetrahydrofolate reductase OS=Polytomella sp.
Pringsheim 198.80 GN=mthfr PE=2 SV=1
Length = 629
Score = 385 bits (990), Expect = e-105, Method: Compositional matrix adjust.
Identities = 180/293 (61%), Positives = 226/293 (77%), Gaps = 4/293 (1%)
Query: 29 TEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTN 88
TE+GV NL ER +R+V++ P FCDITWGAGGSTADVT DIA KMQN VGVETMMHLTCTN
Sbjct: 27 TEEGVENLFERQERLVSYGPVFCDITWGAGGSTADVTQDIAVKMQNLVGVETMMHLTCTN 86
Query: 89 MPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYF 148
MP E+++ AL+ ++ G++N+LALRGD P GQDKF +EGGF+CA DLVK+I+ + G YF
Sbjct: 87 MPKERLEIALKEVQKAGVKNILALRGDAPKGQDKFEAIEGGFSCALDLVKYIKKEFGSYF 146
Query: 149 GITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFAN 208
GI +AGYPEAHPD+I + ++Y ++ YLK KVDAGAD IITQLFYD +IF+KF N
Sbjct: 147 GIGVAGYPEAHPDSIVDDPEQMKKNYFENIEYLKKKVDAGADFIITQLFYDANIFIKFMN 206
Query: 209 DCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHL 268
DCR GITCPI+PGIMPI +Y GF RMT FCKT +P I+ A+E IKD+EEA+K +GI
Sbjct: 207 DCRAAGITCPILPGIMPIASYAGFKRMTSFCKTHVPQHILDAVEAIKDDEEAIKNFGISY 266
Query: 269 GTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPR----TRPAN 317
G EMC+K+LA G +HLYTLNLE+SA+ I++ LG++ E R RPA+
Sbjct: 267 GVEMCRKVLAAGAPGVHLYTLNLERSAVGIVEKLGIMPEQLGSRFPLPWRPAS 319
>E1Z340_CHLVA (tr|E1Z340) Methylenetetrahydrofolate reductase OS=Chlorella
variabilis GN=CHLNCDRAFT_33591 PE=3 SV=1
Length = 328
Score = 379 bits (973), Expect = e-103, Method: Compositional matrix adjust.
Identities = 179/294 (60%), Positives = 221/294 (75%), Gaps = 4/294 (1%)
Query: 2 KVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGST 61
K+I+K++ A K FSFE+FPPKT++GV NL ER RM A P FCDITWGAGGST
Sbjct: 3 KIIDKLNGKIAE--GKSFFSFEYFPPKTDEGVHNLKERQMRMAALGPCFCDITWGAGGST 60
Query: 62 ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQD 121
A+VTLD+A+ MQ VGVETMMHLTCTNMPVEK+ +AL K G+ N+LALRGDPP GQD
Sbjct: 61 AEVTLDVARSMQQEVGVETMMHLTCTNMPVEKLKEALTKAKEYGITNILALRGDPPKGQD 120
Query: 122 KFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYL 181
F VEGGF+CA DLVK+IRA+HGD+FGI ++GYPEAHPD I + ++Y D+ YL
Sbjct: 121 HFEVVEGGFSCALDLVKYIRAEHGDFFGIGVSGYPEAHPDVIVEDERQMRKNYWADIEYL 180
Query: 182 KSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKT 241
K K++AGAD ++TQLFYD D +L+F DCR +GIT PI+PG+MPI Y GF RMT FCKT
Sbjct: 181 KQKMEAGADFVVTQLFYDCDRYLQFVKDCRSVGITAPILPGVMPIMTYGGFKRMTSFCKT 240
Query: 242 KIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSA 295
+P I LE IK ++EA AYGI LGT MC+++LA G +H+YTLNLE+SA
Sbjct: 241 AVPQHIADTLETIKGSDEA--AYGISLGTMMCQRLLASGAPGVHMYTLNLERSA 292
>L8H1T6_ACACA (tr|L8H1T6) Methylenetetrahydrofolate reductase OS=Acanthamoeba
castellanii str. Neff GN=ACA1_267230 PE=3 SV=1
Length = 587
Score = 373 bits (958), Expect = e-101, Method: Compositional matrix adjust.
Identities = 178/318 (55%), Positives = 229/318 (72%), Gaps = 12/318 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI+ AA + + +FSFE+FPPKT++GV+NL ER+DRM + P + D+TWGAGGS
Sbjct: 1 MKIIDKIN--AAIEEKRTMFSFEYFPPKTDEGVINLFERLDRMASFEPEWIDVTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TA TL+I Q G+ETMMHLTCTNMP +IDDAL K+ G+QN+LALRGDPP G+
Sbjct: 59 TAQKTLEICATAQKYCGLETMMHLTCTNMPRAEIDDALRQAKAAGIQNILALRGDPPRGE 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + +VEGGFA A DLV++IRA++GD+FGI +AGYPE H D+ E DL +
Sbjct: 119 E-WKKVEGGFAHAADLVRYIRAEYGDFFGICVAGYPEMHLDS---------ESRDKDLEH 168
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+K+DAGAD IITQLFYDT +FLKF NDCR +GI CPI+PG+MPI Y GF RMT CK
Sbjct: 169 LKAKIDAGADFIITQLFYDTSLFLKFVNDCRALGINCPIIPGMMPIQTYGGFRRMTSLCK 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T IP I ALEPI+D++ AVK YG+ L +MC+ +LA G +H YTLNLEK+ IL+
Sbjct: 229 TFIPEHINKALEPIQDDDSAVKKYGVDLCVQMCRDLLAAGTPGVHFYTLNLEKAVTQILE 288
Query: 301 NLGLIEETSIPRTRPANA 318
+L LI + R P +
Sbjct: 289 DLDLIAASRPSRALPWRS 306
>L1IVS6_GUITH (tr|L1IVS6) Methylenetetrahydrofolate reductase OS=Guillardia theta
CCMP2712 GN=GUITHDRAFT_96413 PE=3 SV=1
Length = 594
Score = 372 bits (956), Expect = e-101, Method: Compositional matrix adjust.
Identities = 178/315 (56%), Positives = 226/315 (71%), Gaps = 4/315 (1%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+++++ E + +SFEFFPPKT GV NL ER++R+ P F DITWGAGGS
Sbjct: 1 MKIVDRLKERNGAP----FYSFEFFPPKTPSGVSNLYERVERLGKLEPLFVDITWGAGGS 56
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+TL+++ Q +ET MHLTCTN+ E + AL+ + G+QN+L LRGDPP GQ
Sbjct: 57 TSDLTLELSSNFQRQFNLETQMHLTCTNVTKETVTQALQQAREAGIQNILCLRGDPPAGQ 116
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGFA A DLV+++R HGDYFGI++AGYPE H D + EDY+ DL Y
Sbjct: 117 EKWEATEGGFANAVDLVRYVRQLHGDYFGISVAGYPEGHIDWFKDTPEISEEDYRRDLQY 176
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+IITQLFYD D+FLK+ DCR+IGI PIVPGIMPIN Y GF RMTGFCK
Sbjct: 177 LKDKVDAGADMIITQLFYDVDVFLKWVKDCREIGINVPIVPGIMPINAYAGFNRMTGFCK 236
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TK+P I LE IKDNE+AVK YG+ L T+MC+++L +G LH+YTLNLEKS +AIL
Sbjct: 237 TKVPKAIRDGLEAIKDNEDAVKEYGVQLVTDMCRRLLDNGIPGLHMYTLNLEKSTVAILN 296
Query: 301 NLGLIEETSIPRTRP 315
NL L++ T+ R P
Sbjct: 297 NLNLLKNTTSRRALP 311
>F0ZME6_DICPU (tr|F0ZME6) Methylenetetrahydrofolate reductase OS=Dictyostelium
purpureum GN=DICPUDRAFT_34262 PE=3 SV=1
Length = 606
Score = 363 bits (931), Expect = 5e-98, Method: Compositional matrix adjust.
Identities = 173/305 (56%), Positives = 222/305 (72%), Gaps = 12/305 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI++ S N +SFE+FPPKT +GV NL +R+ RM+ P F DITWGAGGS
Sbjct: 4 MKIIDKINQKKES--NVPFYSFEYFPPKTMEGVQNLYDRLGRMLLFEPLFIDITWGAGGS 61
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+ +TL+IA+K QN G+ETMMHLTCTNMPV +I AL+ K+ G++N+LALRGDPP G+
Sbjct: 62 TSALTLEIAEKAQNVCGLETMMHLTCTNMPVNEIIYALDKAKATGIRNILALRGDPPRGE 121
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + ++EGGF A DLVK IR ++GDYFGI +AGYPE H D +++D+T+
Sbjct: 122 E-WKKIEGGFGYACDLVKFIRERYGDYFGICVAGYPEGHSDCTS---------FEDDITH 171
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+KVDAGADLIITQLFYD D+F F CR++GI CPI+PGIMPI Y GF+RMT K
Sbjct: 172 LKAKVDAGADLIITQLFYDVDVFCDFVKKCREVGINCPIIPGIMPIQTYAGFVRMTTLSK 231
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
TK+P IM LEPIKDN+E VK YG+ L EM K++L G + LH YTLNLE+S +LK
Sbjct: 232 TKVPQYIMDNLEPIKDNDEEVKKYGVRLCVEMSKRLLEFGVEGLHFYTLNLERSVRKVLK 291
Query: 301 NLGLI 305
L L+
Sbjct: 292 GLELV 296
>D3BTZ2_POLPA (tr|D3BTZ2) Methylenetetrahydrofolate reductase OS=Polysphondylium
pallidum GN=PPL_11252 PE=3 SV=1
Length = 608
Score = 362 bits (929), Expect = 1e-97, Method: Compositional matrix adjust.
Identities = 171/315 (54%), Positives = 225/315 (71%), Gaps = 12/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI+E + N+ +SFE+FPPKT +GV NL +R+ RM+ P F DITWGAGGS
Sbjct: 8 MKIIDKINEYKSK--NQRFYSFEYFPPKTMEGVQNLYDRLGRMLLLEPLFVDITWGAGGS 65
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+ +TL+IA+ QN G+ETMMHLTCTNM VE+ID ALE K++G++N+LALRGDPP G+
Sbjct: 66 TSQLTLEIAETSQNICGLETMMHLTCTNMKVEEIDFALEKAKASGVRNILALRGDPPRGE 125
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + ++EGGF A DLV++IR KHGD+FGI +AGYPE H D ++DL +
Sbjct: 126 E-WKKIEGGFGYASDLVRYIRQKHGDHFGIAVAGYPEGHSDCTSK---------EDDLQH 175
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+K+DAGADLIITQLFYD D+F F CR IGI CPI+PGIMPI+ Y GF RMT +
Sbjct: 176 LKNKIDAGADLIITQLFYDVDMFNDFVGKCRAIGINCPIIPGIMPIHTYAGFKRMTTLSQ 235
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T +P I+ ALEPIKDN+E VK YG+ L +MC++++ G LH YTLNLE+S +LK
Sbjct: 236 TAVPPHILEALEPIKDNDEEVKKYGVKLCVQMCERLVEAGVDGLHFYTLNLERSVRKVLK 295
Query: 301 NLGLIEETSIPRTRP 315
L ++ + R P
Sbjct: 296 GLNMVRPDQLARYLP 310
>K3WKM9_PYTUL (tr|K3WKM9) Methylenetetrahydrofolate reductase OS=Pythium ultimum
GN=PYU1_G005510 PE=3 SV=1
Length = 590
Score = 360 bits (924), Expect = 4e-97, Method: Compositional matrix adjust.
Identities = 167/315 (53%), Positives = 219/315 (69%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI++ + N+V +SFEFFPPKT GV NL RMDRM + P FCD+TWGAGGS
Sbjct: 1 MKIIDKINQCI--EKNEVFYSFEFFPPKTPAGVDNLYTRMDRMASLEPLFCDMTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+A +T+DI+ Q G+E +MH+TCTNM E + +ALE K G+ N+LALRGDP G
Sbjct: 59 SAQLTIDISANAQKLSGLEMLMHMTCTNMAEEDVKNALEKAKDAGITNILALRGDPVRGA 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
F + + GF+ A DLV++I+ +GD+F I +AGYPE H +++ D D+ Y
Sbjct: 119 VSFNECDRGFSHAVDLVRYIKEHYGDHFSIGVAGYPERHAESV---------DSATDIKY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGAD +ITQLFYD ++++KF DCR++GITCPI+PGIMPI NY GF+RMT FC
Sbjct: 170 LKEKIDAGADFVITQLFYDVNVYVKFVEDCRKVGITCPIIPGIMPIQNYGGFVRMTSFCS 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T +P EI ALEPIKDN+EAVK YG+ LG EMCK+++A G LH YTLNLE+S IL
Sbjct: 230 TYVPEEITTALEPIKDNDEAVKDYGVELGIEMCKQLMAAGAPGLHFYTLNLERSVRRILD 289
Query: 301 NLGLIEETSIPRTRP 315
L + + R P
Sbjct: 290 GLSITSSNASRRELP 304
>D2V2R1_NAEGR (tr|D2V2R1) Methylenetetrahydrofolate reductase OS=Naegleria
gruberi GN=NAEGRDRAFT_35291 PE=3 SV=1
Length = 594
Score = 357 bits (916), Expect = 3e-96, Method: Compositional matrix adjust.
Identities = 177/330 (53%), Positives = 224/330 (67%), Gaps = 21/330 (6%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI++ + NK +SFE+FPPKT+ GV NL +R+ RM +P F DITWGAGGS
Sbjct: 1 MKIIDKINQCI--EENKTFYSFEYFPPKTDAGVENLYQRLQRMAKLAPMFIDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TA T++I QN +GVET +H+TCTNM VE++D A++T K G+ N+LALRGDPP G
Sbjct: 59 TAGKTIEIGATAQNMIGVETQIHMTCTNMKVEELDKAIQTAKDMGISNILALRGDPPLGS 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + Q +GGF ARDL+ HIR HGDYFGI+ AGY E HP+ DYQ DL Y
Sbjct: 119 EDWEQTDGGFKYARDLISHIRKTHGDYFGISCAGYSEGHPEG----------DYQKDLMY 168
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAGAD ++TQLFYD FLKF + R+IGI CPI+PGIMPINN+ + RMT FCK
Sbjct: 169 LKEKYDAGADFVVTQLFYDWQQFLKFVKEAREIGIKCPIIPGIMPINNHASWQRMTTFCK 228
Query: 241 TKIPAEI---MAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALA 297
T IP + MA L DNE VKAYGI L +C+ ++ +G + LH YTLNLEKS A
Sbjct: 229 TSIPQNVHDEMAKLNLEDDNE--VKAYGIKLCITICRALMDNGIRGLHFYTLNLEKSTEA 286
Query: 298 ILKNLGLIEETSIPRT----RPANAIQAKE 323
IL+ L L + SIPR+ +PANA + E
Sbjct: 287 ILEGLELSPKESIPRSLPWVKPANAKRLAE 316
>Q54X84_DICDI (tr|Q54X84) Methylenetetrahydrofolate reductase OS=Dictyostelium
discoideum GN=DDB_G0279137 PE=3 SV=1
Length = 627
Score = 355 bits (910), Expect = 2e-95, Method: Compositional matrix adjust.
Identities = 168/292 (57%), Positives = 210/292 (71%), Gaps = 10/292 (3%)
Query: 14 DPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQ 73
+ N +SFE+FPPKT +GV NL +R+ RM+ P F DITWGAGGST+ +TL+IA+K Q
Sbjct: 15 ESNTPFYSFEYFPPKTMEGVQNLYDRLGRMLLFEPLFIDITWGAGGSTSALTLEIAEKAQ 74
Query: 74 NTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACA 133
N G+ETMMHLTCTNMPV +I AL+ KS G++N+LALRGDPP G++ + ++EGGFA A
Sbjct: 75 NVCGLETMMHLTCTNMPVSEIIYALDKAKSTGIRNILALRGDPPRGEE-WKKIEGGFAYA 133
Query: 134 RDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLII 193
DLV+ IR K+GDYF I++AGYPE H D + + D+ YLK KVDAGAD II
Sbjct: 134 ADLVRFIREKYGDYFCISVAGYPEGHSDCVSK---------EEDIRYLKEKVDAGADFII 184
Query: 194 TQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEP 253
TQLFYD DIF +F CR +GI CPI+PGIMPI Y GF+RMT KTK+P IM LEP
Sbjct: 185 TQLFYDCDIFCEFVEKCRSVGINCPIIPGIMPIQTYAGFVRMTTLSKTKVPQYIMDNLEP 244
Query: 254 IKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLI 305
IKDN+E VK YG+ L EM K++L G + LH YTLNLE+S +LK L L+
Sbjct: 245 IKDNDEEVKKYGVRLCVEMSKRLLDFGVEGLHFYTLNLERSVRKVLKGLQLV 296
>R7Q356_CHOCR (tr|R7Q356) Methylenetetrahydrofolate reductase OS=Chondrus crispus
GN=CHC_T00008486001 PE=4 SV=1
Length = 631
Score = 352 bits (904), Expect = 7e-95, Method: Compositional matrix adjust.
Identities = 164/297 (55%), Positives = 216/297 (72%), Gaps = 6/297 (2%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKTE GV NL +R++RM A P FCD+TWGAGGST+D+TL ++ +Q +GV+
Sbjct: 43 FSFEYFPPKTEQGVSNLYQRVERMTAAEPLFCDVTWGAGGSTSDLTLSLSGNIQKYLGVD 102
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
MMHLTCTNMP + + LE K+ G++N+LALRGDPP G++ + + E GF DLV+
Sbjct: 103 VMMHLTCTNMPSGNVLEGLEGAKALGIRNILALRGDPPAGKE-WTKCEDGFEHGTDLVRF 161
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IRA +GDYFGI +AGYPE HP ++ +++++ +LK KVDAGAD IITQ+FYD
Sbjct: 162 IRANYGDYFGICVAGYPEGHPAGFLDGKMS----FEDEMKHLKDKVDAGADFIITQMFYD 217
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D +LKF CR+ GIT PI+PGI+PI NY GF RMTGFCKTK+P I+ A+E IKDN+
Sbjct: 218 VDCYLKFVRSCREQGITIPILPGILPIQNYMGFKRMTGFCKTKVPQAILDAIEQIKDNDV 277
Query: 260 AVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
AVK +G+ LG +MC++IL G +H YTLNLEKSA+AI+ L LI +T R+ P
Sbjct: 278 AVKQFGVRLGVDMCRRILKSGLSPGIHFYTLNLEKSAMAIIDQLDLIPQTESIRSLP 334
>F4PLP1_DICFS (tr|F4PLP1) Methylenetetrahydrofolate reductase OS=Dictyostelium
fasciculatum (strain SH3) GN=DFA_05596 PE=3 SV=1
Length = 595
Score = 349 bits (896), Expect = 6e-94, Method: Compositional matrix adjust.
Identities = 170/307 (55%), Positives = 217/307 (70%), Gaps = 13/307 (4%)
Query: 9 EAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDI 68
E A+ P +SFE+FPPKT +GV NL +R+ RM+ P F DITWGAGGST+++TL+I
Sbjct: 13 ENGATTP---FYSFEYFPPKTMEGVQNLYDRLGRMLLLEPLFVDITWGAGGSTSELTLEI 69
Query: 69 AKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEG 128
A QN G+ETMMHLTCTNM V +ID AL K +G++N+LALRGDPP G++ + ++EG
Sbjct: 70 ADTAQNICGLETMMHLTCTNMQVSQIDFALAKAKESGVRNILALRGDPPRGEE-WKKIEG 128
Query: 129 GFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAG 188
GFA A DLV++IR +GDYFGI +AGYPE H DA ++DL +LK+KVD G
Sbjct: 129 GFAHASDLVRYIRQHYGDYFGIAVAGYPEGHSDATS---------LEDDLQHLKTKVDMG 179
Query: 189 ADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIM 248
ADLIITQLFYD D+F++F CR IGI PI+PGIMPI+ Y GF RMT KT +P I+
Sbjct: 180 ADLIITQLFYDVDMFVEFVGKCRAIGINVPIIPGIMPIHTYAGFKRMTTLSKTVVPQHIL 239
Query: 249 AALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEET 308
ALEPIKDN+E VK YG++L EMCK+++A G LH YTLNLE+S +LK L +I
Sbjct: 240 DALEPIKDNDEEVKKYGVNLCIEMCKQMVAAGVDGLHFYTLNLERSVRKVLKGLEMIRPD 299
Query: 309 SIPRTRP 315
+ R P
Sbjct: 300 QLHRYLP 306
>M2XB69_GALSU (tr|M2XB69) Methylenetetrahydrofolate reductase OS=Galdieria
sulphuraria GN=Gasu_52550 PE=3 SV=1
Length = 625
Score = 347 bits (889), Expect = 5e-93, Method: Compositional matrix adjust.
Identities = 163/313 (52%), Positives = 218/313 (69%), Gaps = 8/313 (2%)
Query: 6 KIHEAAA--SDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTAD 63
K+HE D K+ FSFE+FPPKT GV NL +R+DRM P F D+TWGAGGST+D
Sbjct: 14 KVHEKIKHRQDMGKIFFSFEYFPPKTPSGVDNLYDRIDRMSRVEPLFVDVTWGAGGSTSD 73
Query: 64 VTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKF 123
+TL+I+ +Q G++ MHLTCTNMP K+DDAL K G++N++ALRGDPP G++ +
Sbjct: 74 LTLEISGNIQRYFGLDVCMHLTCTNMPSGKVDDALNAAKERGIRNIVALRGDPPKGEE-W 132
Query: 124 VQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKS 183
+EGGF A DLV+HIR G++F I +AGYPE HP + L Y+ +L +LK
Sbjct: 133 HSIEGGFEHAVDLVRHIRKSFGEHFSICVAGYPEGHPAGLLEGNLT----YEQELHFLKE 188
Query: 184 KVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKI 243
KV+AG + IITQ+FYDTD FL+F DCR IGI PI+PGI+PI NY GF RMT FCKT +
Sbjct: 189 KVEAGGNFIITQMFYDTDRFLQFVKDCRSIGIEVPIIPGILPIQNYNGFERMTKFCKTHV 248
Query: 244 PAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSALAILKNL 302
P E++ AL+PIKD++ AVK +GI LG +MC++IL G +H YTLNLEK+ ++I++ L
Sbjct: 249 PDEVLKALQPIKDDDAAVKEFGIRLGIDMCRRILHSGLVPGIHFYTLNLEKAVMSIIEGL 308
Query: 303 GLIEETSIPRTRP 315
+I + R+ P
Sbjct: 309 DMIPKNQSIRSLP 321
>D0N474_PHYIT (tr|D0N474) Methylenetetrahydrofolate reductase OS=Phytophthora
infestans (strain T30-4) GN=PITG_05377 PE=3 SV=1
Length = 591
Score = 337 bits (865), Expect = 3e-90, Method: Compositional matrix adjust.
Identities = 163/312 (52%), Positives = 213/312 (68%), Gaps = 12/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI+ A+ + +V +SFEFFPPKT GV NL RMDRM A P FCD+TWGAGGS
Sbjct: 1 MKVIDKIN--ASLERQEVFYSFEFFPPKTPAGVDNLYARMDRMAALEPLFCDMTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+A +TL+++ Q G+E +MH+TCTNM I AL+ K G+QN+LALRGDP G
Sbjct: 59 SAQLTLELSANAQKLSGLEMLMHMTCTNMADADIKKALDQAKDAGIQNILALRGDPVRGA 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
F + + GF+ A DLV++IR K+G++F I +AGYPE H + +D + D+ Y
Sbjct: 119 TSFDECDRGFSHAVDLVRYIREKYGNHFCIGVAGYPEGHTEF---------KDKKADIQY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD +ITQLFYD +F+ F +CR +GIT PI+PGIMPI NY GF RMT FC
Sbjct: 170 LKEKVDAGADFVITQLFYDVKVFVDFVKECRAVGITVPIIPGIMPIQNYGGFERMTSFCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T +P E+ ALEPIKDN+EAVK YG+ LG M ++++ G LH YTLNLE+S IL+
Sbjct: 230 THVPDEVRKALEPIKDNDEAVKDYGVQLGITMSQQLIDAGVPGLHFYTLNLERSVRRILE 289
Query: 301 NLGLIEETSIPR 312
L + + +PR
Sbjct: 290 GLSSL-SSRVPR 300
>M1UY35_CYAME (tr|M1UY35) Methylenetetrahydrofolate reductase OS=Cyanidioschyzon
merolae strain 10D GN=CYME_CMT610C PE=3 SV=1
Length = 635
Score = 336 bits (862), Expect = 6e-90, Method: Compositional matrix adjust.
Identities = 157/300 (52%), Positives = 209/300 (69%), Gaps = 6/300 (2%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
K +SFEFFPPKTE G++ L ER+ R+ P F D+TWGAGGST+D+TL+++ +Q
Sbjct: 45 KRFYSFEFFPPKTEQGLLGLYERIARLSRLEPLFVDVTWGAGGSTSDLTLELSGNIQKFF 104
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G++ MHLTCTNM +D ALE + G++N+++LRGDPP GQ+ + Q + GFA A DL
Sbjct: 105 GLDVAMHLTCTNMEEGMVDKALEEARKRGIRNIVSLRGDPPVGQE-WRQCKDGFAHASDL 163
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
V+H+R +GDYF + +AGYPE HP + L Y+ +L YLK KVDAG DLIITQ+
Sbjct: 164 VRHVRKVYGDYFCLIVAGYPEGHPAGLLDGKLT----YEQELNYLKEKVDAGGDLIITQM 219
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL+F DCR IGI PI+PGI+PI +Y GF RMTGFC+T +P + +E +KD
Sbjct: 220 FYDVDQFLRFVRDCRSIGIQVPILPGILPIQSYSGFKRMTGFCRTHVPEAVAETVERLKD 279
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
+EEAVK +GI GTEMC++IL LH YTLNLEK+ ++IL+NLGL+ + R P
Sbjct: 280 DEEAVKNFGIEYGTEMCRRILNSKLSLGLHFYTLNLEKATVSILENLGLVPKFESVRALP 339
>G4YYD3_PHYSP (tr|G4YYD3) Methylenetetrahydrofolate reductase OS=Phytophthora
sojae (strain P6497) GN=PHYSODRAFT_541479 PE=3 SV=1
Length = 591
Score = 336 bits (862), Expect = 6e-90, Method: Compositional matrix adjust.
Identities = 163/312 (52%), Positives = 211/312 (67%), Gaps = 12/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+IEKI+ A+ + +V +SFEFFPPKT GV NL RMDRM A P FCD+TWGAGGS
Sbjct: 1 MKIIEKIN--ASVERQEVFYSFEFFPPKTPAGVDNLYARMDRMAALEPLFCDMTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+A +TL+++ Q G+E +MH+TCTNM I AL+ K G+ N+LALRGDP G
Sbjct: 59 SAQLTLELSANAQKLSGLEMLMHMTCTNMAEADIKKALDQAKDAGIHNILALRGDPVRGA 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
F + + GF+ A DLV+++R +GD+F I +AGYPE H ++ D + D+ Y
Sbjct: 119 TSFDECDRGFSHAVDLVRYMREHYGDHFCIGVAGYPEGHMES---------SDKKADIQY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD IITQLFYD +F+ F +CR +GIT PI+PGIMPI NY GF RMT FC
Sbjct: 170 LKEKVDAGADFIITQLFYDVQVFVDFVKECRAVGITVPIIPGIMPIQNYGGFERMTSFCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T +P E+ ALEPIKDN+EAVK YG+ LG M ++++ G LH YTLNLE+S IL+
Sbjct: 230 TFVPEEVRKALEPIKDNDEAVKDYGVQLGITMSQQLIDAGVPGLHFYTLNLERSVRRILE 289
Query: 301 NLGLIEETSIPR 312
L L + +PR
Sbjct: 290 GL-LSLSSRVPR 300
>H3GAC2_PHYRM (tr|H3GAC2) Methylenetetrahydrofolate reductase OS=Phytophthora
ramorum PE=3 SV=1
Length = 591
Score = 334 bits (856), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 161/312 (51%), Positives = 211/312 (67%), Gaps = 12/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI+ A+ + + +SFEFFPPKT GV NL RMDRM A P FCD+TWGAGGS
Sbjct: 1 MKIIDKIN--ASVERQECFYSFEFFPPKTPAGVDNLYARMDRMAALEPLFCDMTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+A +TL+++ Q G+E +MH+TCTNM I AL+ K G+QNVLALRGDP G
Sbjct: 59 SAQLTLELSANAQKLSGLEMLMHMTCTNMAEADIKKALDQAKDAGIQNVLALRGDPVRGA 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
F + + GF+ A DLV+ +R +GD+F I +AGYPE H ++ +D + D+ Y
Sbjct: 119 SSFDECDRGFSHAVDLVRFMRETYGDHFCIGVAGYPEGHTES---------QDKKLDIQY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD IITQLFYD +F+ F +CR +GIT PI+PGIMPI NY GF RMT FC
Sbjct: 170 LKEKVDAGADFIITQLFYDVKVFVDFVKECRAVGITVPIIPGIMPIQNYGGFERMTSFCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T +P ++ ALEPIKDN+EAVK YG+ LG M ++++ G LH YTLNLE+S IL+
Sbjct: 230 TFVPEDVRKALEPIKDNDEAVKDYGVQLGITMSQQLIDAGVPGLHFYTLNLERSVRRILE 289
Query: 301 NLGLIEETSIPR 312
L + + +PR
Sbjct: 290 GLSSL-SSRVPR 300
>F4P4P0_BATDJ (tr|F4P4P0) Methylenetetrahydrofolate reductase OS=Batrachochytrium
dendrobatidis (strain JAM81 / FGSC 10211)
GN=BATDEDRAFT_16794 PE=3 SV=1
Length = 592
Score = 333 bits (853), Expect = 6e-89, Method: Compositional matrix adjust.
Identities = 164/317 (51%), Positives = 213/317 (67%), Gaps = 11/317 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV++KI +A +D + +SFE+FPPKTE GVVNL +RM+RM P F D+TWGAGG+
Sbjct: 1 MKVVDKIQKA--NDEGRCFWSFEYFPPKTESGVVNLFDRMERMYLLGPEFIDVTWGAGGT 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+TL+I Q G+ET MHLTCTNMP KID+ALE K+ G+ N+LALRGD P GQ
Sbjct: 59 TSDLTLEICTTAQAVFGLETCMHLTCTNMPRIKIDEALEQAKNAGIMNILALRGDAPRGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ +VE GF+ A DLV++IR K+GDYF I +AGYPE H + TP D + DL Y
Sbjct: 119 TNWTKVETGFSYATDLVRYIREKYGDYFCIGVAGYPEGHTE--------TP-DKEADLLY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV AGAD I+TQLFYD DI++ ++ R + IT PI+PG++PI NY GF RMT K
Sbjct: 170 LKEKVLAGADYIVTQLFYDVDIYIDWSKKVRAMDITIPILPGLLPIQNYSGFKRMTALSK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T +P I+ LEPIKD+++AVK YGI L +MC K+ G + H Y LNLE+S IL+
Sbjct: 230 TFVPQFILDDLEPIKDDDQAVKDYGIRLAVQMCNKMREAGQRGFHFYCLNLERSTRLILE 289
Query: 301 NLGLIEETSIPRTRPAN 317
L + + P N
Sbjct: 290 GLDFVAPRENVKPLPWN 306
>D8LCN9_ECTSI (tr|D8LCN9) Methylenetetrahydrofolate reductase OS=Ectocarpus
siliculosus GN=Esi_0011_0107 PE=3 SV=1
Length = 399
Score = 327 bits (838), Expect = 4e-87, Method: Compositional matrix adjust.
Identities = 156/312 (50%), Positives = 206/312 (66%), Gaps = 27/312 (8%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
S EFFPP+T+ GV+NL++R+ RM A P F D TWGAGGSTAD+TLD+ + + G+
Sbjct: 30 SLEFFPPRTDTGVMNLMDRLGRMKATKPLFVDFTWGAGGSTADLTLDLTTRTKKEHGLVP 89
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCTNMPV+KID AL K +G++N++ALRGDPP G D + EGGF CA DLVK+I
Sbjct: 90 NMHLTCTNMPVDKIDHALAQCKEHGIRNIVALRGDPPTGSDTWEAAEGGFTCALDLVKYI 149
Query: 141 RAKHGDYFGITIAGYPEAHPDAI-----GSNGLATPE----------------------D 173
R HGDYFGI++AGYPE HP+ I G L+ E D
Sbjct: 150 RKNHGDYFGISVAGYPEGHPNRIKEVPGGVESLSEAEKGRCKISQDAEGKEVVTVCSDAD 209
Query: 174 YQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFI 233
++ ++ Y+K KVDAGAD IITQ+F+D ++ + CR GI P+VPG+M IN Y GF
Sbjct: 210 FEIEMNYIKEKVDAGADFIITQMFFDPAVYASYIKACRDRGIEVPVVPGLMCINAYGGFK 269
Query: 234 RMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEK 293
+MTGFC T++P E+MA +E +K++E+AVKA+G+ G +MC +LA G LH YTLNLEK
Sbjct: 270 KMTGFCLTRVPPELMAKMEEMKEDEKAVKAFGVDYGEKMCNALLAAGAPGLHFYTLNLEK 329
Query: 294 SALAILKNLGLI 305
+ IL L L+
Sbjct: 330 VTVGILDRLNLL 341
>I1BPZ7_RHIO9 (tr|I1BPZ7) Methylenetetrahydrofolate reductase OS=Rhizopus delemar
(strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
43880) GN=RO3G_02981 PE=3 SV=1
Length = 598
Score = 322 bits (824), Expect = 2e-85, Method: Compositional matrix adjust.
Identities = 159/327 (48%), Positives = 209/327 (63%), Gaps = 15/327 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKVI+KI A + +SFE+FPPKT GV NL +RM+RM + P F D+TWGAGG+
Sbjct: 1 MKVIDKIKRAEQE--GRSFWSFEYFPPKTPQGVQNLYDRMERMQRYGPEFVDVTWGAGGT 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+AD+T +I Q+ G+ETMMHLTCTNMPV++IDDALE K G QN+LALRGDPP GQ
Sbjct: 59 SADLTTEIVATAQSVYGLETMMHLTCTNMPVQQIDDALEAAKKCGCQNILALRGDPPKGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ E GF A DLV++IR K+GDYF I +AG+PE H D D ++DL
Sbjct: 119 ANWESCESGFEHAVDLVRYIRQKYGDYFCIAVAGHPEGHIDN---------PDKEDDLLR 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADL++TQLF+D + F+ F + R IGI CPI+PG+ PI NY G R+ F
Sbjct: 170 LKEKVDAGADLVVTQLFFDIEAFITFYHKARAIGIECPILPGVFPIQNYSGLKRVIAFND 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P +I LE IK+++ AVK YGI+L + K+ G HLYT NLE+S+ +L+
Sbjct: 230 NFVPQKIWDELESIKEDDTAVKEYGINLTVDFIKRFRQEGINGFHLYTFNLERSSRLVLE 289
Query: 301 NLGLIEETS----IPRTRPANAIQAKE 323
L L+ +P + N +AKE
Sbjct: 290 RLELVAPIENIKPLPWSPSLNNKRAKE 316
>F0W2Q3_9STRA (tr|F0W2Q3) Methylenetetrahydrofolate reductase OS=Albugo laibachii
Nc14 GN=AlNc14C10G1291 PE=3 SV=1
Length = 589
Score = 319 bits (817), Expect = 9e-85, Method: Compositional matrix adjust.
Identities = 156/310 (50%), Positives = 204/310 (65%), Gaps = 12/310 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M+ I+KI + + +V FSFEFFPPKT GV NL +R+DR+ P FCD+TWGAGGS
Sbjct: 1 MRAIDKITDCISK--KQVFFSFEFFPPKTAAGVQNLYKRIDRLGQLGPLFCDVTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T++I+ Q +G++ +MHLTC N+ E AL+ ++ G+QN+L LRGDP G
Sbjct: 59 NHGSTIEISSNAQK-MGMDILMHLTCVNLTPENAITALDAARNAGIQNILVLRGDPVQGA 117
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
F + + GF+ A DL++ IR K+ D F I +A +PE H A D Q +L Y
Sbjct: 118 SSFEECDKGFSHAIDLIRFIRKKYKDAFCIGVAAHPEGHLHA---------ADKQQELVY 168
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA IITQLFYD ++ +F +CRQIGITCPI+PG+MPI Y GF+RMT FC+
Sbjct: 169 LKEKVDAGAGFIITQLFYDVFVYKEFVCECRQIGITCPIIPGVMPIQTYGGFVRMTSFCE 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
++P EI ALEPIK N+EAVK YGI LG +MC+K+L G LH YTLNLE++ AIL
Sbjct: 229 ARVPGEIQDALEPIKGNDEAVKEYGIRLGVKMCRKLLEDGAPGLHFYTLNLERAVRAILS 288
Query: 301 NLGLIEETSI 310
L L+ SI
Sbjct: 289 ELNLVNVNSI 298
>J9J1L8_9SPIT (tr|J9J1L8) Methylenetetrahydrofolate reductase OS=Oxytricha
trifallax GN=OXYTRI_12424 PE=3 SV=1
Length = 596
Score = 315 bits (806), Expect = 2e-83, Method: Compositional matrix adjust.
Identities = 144/308 (46%), Positives = 212/308 (68%), Gaps = 11/308 (3%)
Query: 1 MKVIEKIHEAAASDPN--KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAG 58
MK+I+KI++ D + K +SFE+FP +TE G+ NLL+R++RM + +P + D+TW AG
Sbjct: 1 MKIIDKINQVLEEDQSNKKTFYSFEYFPARTEQGIENLLDRIERMGSTNPLWVDVTWNAG 60
Query: 59 GSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
GS++D TL++ +QN G++ +MHLTCT M EKI +L+ K G++N+LALRGDPP
Sbjct: 61 GSSSDQTLELCSHIQNFSGLDVLMHLTCTFMDREKIVSSLDRAKELGIKNLLALRGDPPR 120
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
G ++ +E GF A DLVK IR ++GDYF I +AGYPE H A ++D+
Sbjct: 121 GAKDWIPIENGFNYAVDLVKFIREQYGDYFCIGVAGYPEVHLSATSR---------EDDI 171
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK KVDAGAD IITQLFYD ++F+++ DCR+ GI C I+PGI+PI Y+ F + F
Sbjct: 172 RYLKEKVDAGADFIITQLFYDNNLFVEWVADCRRAGIECQIIPGILPILGYERFNKTIQF 231
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAI 298
CKT +P +I+ LEPIK+++E V+ YG+ G E C++++ G + LH YT+NLE + + I
Sbjct: 232 CKTIVPQKILDDLEPIKNDDEEVRKYGVKFGIEQCRELIDQGTRFLHFYTMNLETAVVNI 291
Query: 299 LKNLGLIE 306
+K LG+++
Sbjct: 292 IKGLGILD 299
>J4GI53_FIBRA (tr|J4GI53) Methylenetetrahydrofolate reductase OS=Fibroporia
radiculosa (strain TFFH 294) GN=FIBRA_00597 PE=3 SV=1
Length = 603
Score = 314 bits (804), Expect = 3e-83, Method: Compositional matrix adjust.
Identities = 155/307 (50%), Positives = 209/307 (68%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV +KI A A ++V +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MKVSQKI--ALAEKEDRVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G+ET MHLTCTNMP EK+D AL+ K +G +NVLALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQKLIGMETCMHLTCTNMPREKVDVALKEAKEHGCRNVLALRGDPPMGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D++ VEGGF DLVKHIR+++GDYF I I G+P+ + L PE++ +L Y
Sbjct: 119 DEWEAVEGGFVHGIDLVKHIRSQYGDYFDIVIPGFPQ--------HVLLPPEEFALELQY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG++LI TQ+FYD DIF+K+ + R GIT PIVPGI PI + GF + T K
Sbjct: 171 LKEKIDAGSNLIFTQMFYDVDIFIKWVHAVRAAGITIPIVPGIAPIQTWNGFQKATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
TKIP + ALEP K+N+E V+ G L ++C+ +L G K LH YT+NLEK+ +
Sbjct: 231 TKIPQLFLDALEPHKNNDEKVREIGTKLVADVCRYLLDAQIGIKGLHFYTMNLEKATRML 290
Query: 299 LKNLGLI 305
L+ L L+
Sbjct: 291 LEELNLV 297
>A8N945_COPC7 (tr|A8N945) Methylenetetrahydrofolate reductase OS=Coprinopsis
cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC
9003) GN=CC1G_00920 PE=3 SV=2
Length = 614
Score = 313 bits (803), Expect = 4e-83, Method: Compositional matrix adjust.
Identities = 148/307 (48%), Positives = 204/307 (66%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M++ +KI ++A D KV +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MRISQKIQQSAKED--KVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G+ET MHLTCTNMP EK+D AL+ K +G +N+LALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGIETCMHLTCTNMPREKVDTALKEAKEHGCRNILALRGDPPMGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D++ VEGGF DLV+HIR +GDYF I + G+P+ + L PE+ N++ +
Sbjct: 119 DEWEAVEGGFVHGIDLVRHIRKHYGDYFDIAVPGFPQ--------HMLLPPEERDNEIRW 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+D G + I TQ+F+D DIF+ + R GIT PIVPGIMPI + GFI+ T
Sbjct: 171 LKEKIDEGVNFIFTQMFFDVDIFISWVKAVRAAGITIPIVPGIMPIQTWNGFIKATNLAS 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
TKIP + ALEP+K ++E V+ G L +MC+KIL G + LH YT+NLEK +
Sbjct: 231 TKIPQFFLDALEPVKSDDEKVREVGTKLVADMCRKILDSGLGIRGLHFYTMNLEKGTRML 290
Query: 299 LKNLGLI 305
L+ L L+
Sbjct: 291 LEELNLV 297
>C5E2N6_LACTC (tr|C5E2N6) Methylenetetrahydrofolate reductase OS=Lachancea
thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL
Y-8284) GN=KLTH0H06446g PE=3 SV=1
Length = 599
Score = 313 bits (802), Expect = 5e-83, Method: Compositional matrix adjust.
Identities = 149/309 (48%), Positives = 203/309 (65%), Gaps = 11/309 (3%)
Query: 1 MKVIEKIHE-AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M+V EK+ + A+ +K FSFEFF PKT GV NL +RMDRM P F DITW AGG
Sbjct: 1 MRVSEKLQKNREANGTSKATFSFEFFVPKTSQGVQNLYDRMDRMYQTHPQFIDITWNAGG 60
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
+ ++ ++ Q+ +G+ET MHLTCTNMP + IDDAL+ +G QN+LALRGD P
Sbjct: 61 RLSQLSTELVSTSQSVLGLETCMHLTCTNMPRQLIDDALQKAYESGCQNILALRGDAPIT 120
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
++ EGGF A+DLV++IR K+GD+F I +AGYPE HP+ S L +
Sbjct: 121 SSEWKPCEGGFTYAKDLVRYIREKYGDHFDIGVAGYPEGHPEEEASPKL---------VQ 171
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGAD IITQ+FYD D F+++ R GI PI+PGIMPI Y F+R + +C
Sbjct: 172 YLKEKVDAGADFIITQMFYDADNFIEWCRQVRAAGIEVPIIPGIMPITTYAAFLRRSSWC 231
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALAI 298
+ +P MA L+P+KD+++AV+ G L +MC+K+L G+ T LH+YT+NLEK+ + +
Sbjct: 232 QINVPEAFMAKLDPVKDDDQAVREVGTELVAQMCQKLLDSGYVTHLHMYTMNLEKACIMV 291
Query: 299 LKNLGLIEE 307
L LGL+ E
Sbjct: 292 LDRLGLLSE 300
>K5WIH4_PHACS (tr|K5WIH4) Methylenetetrahydrofolate reductase OS=Phanerochaete
carnosa (strain HHB-10118-sp) GN=PHACADRAFT_264540 PE=3
SV=1
Length = 624
Score = 312 bits (800), Expect = 9e-83, Method: Compositional matrix adjust.
Identities = 152/317 (47%), Positives = 206/317 (64%), Gaps = 12/317 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +KI +A +V +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MKISKKIQQAEKE--GRVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFVDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G ET MHLTCTNMP EKID AL KS+G +N+LALRGDPP G+
Sbjct: 59 TSDLTSELVKTCQGLIGTETCMHLTCTNMPTEKIDVALREAKSHGCRNILALRGDPPMGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D++ VEGGF DLV+HIR ++GDYF I +AG+P+ + PE+ ++ +
Sbjct: 119 DEWEAVEGGFVHGIDLVQHIRKEYGDYFDIAVAGFPQ--------HVTLPPEERDQEIQW 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I TQ+FYD +IF+++ R GIT PIVPGI PI + GFI+ T
Sbjct: 171 LKEKVDAGADFIFTQMFYDVEIFIEWVKQVRAAGITIPIVPGIAPIQTWNGFIKSTTLSG 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T IP + LEP K+N+E V+ GI L +MC++ILA G + LH YT+NLEK +
Sbjct: 231 TTIPQLVRDQLEPFKNNDEKVREIGIKLVADMCRRILAEPLGVRGLHFYTMNLEKGTRML 290
Query: 299 LKNLGLIEETSIPRTRP 315
L+ L L+ + + P
Sbjct: 291 LEELKLVPRVEVVKPLP 307
>C5FFF6_ARTOC (tr|C5FFF6) Methylenetetrahydrofolate reductase OS=Arthroderma otae
(strain ATCC MYA-4605 / CBS 113480) GN=MCYG_02222 PE=3
SV=1
Length = 623
Score = 311 bits (798), Expect = 1e-82, Method: Compositional matrix adjust.
Identities = 152/295 (51%), Positives = 195/295 (66%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+D+AL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMPREKVDEALQSAFKAGCTNILALRGDPPREKESWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CR+ GIT PI+PGIMPI+ Y FIR T + K KIP M ALEP+K+++ A
Sbjct: 190 DNFLDWVKRCRKAGITVPIIPGIMPISTYAAFIRRTNWVKCKIPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L +EMC+K+L +G LH YT+NL +S +L+ L L T P +P
Sbjct: 250 VKQIGRALVSEMCRKLLDNGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKP 304
>D4AYQ9_ARTBC (tr|D4AYQ9) Methylenetetrahydrofolate reductase OS=Arthroderma
benhamiae (strain ATCC MYA-4681 / CBS 112371)
GN=ARB_01328 PE=3 SV=1
Length = 623
Score = 311 bits (798), Expect = 2e-82, Method: Compositional matrix adjust.
Identities = 151/295 (51%), Positives = 193/295 (65%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+DDAL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMPREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CRQ GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+++ A
Sbjct: 190 DNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L +EMC+K+L +G LH YT+NL +S +L+ L L T P +P
Sbjct: 250 VKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKP 304
>F2S694_TRIT1 (tr|F2S694) Methylenetetrahydrofolate reductase OS=Trichophyton
tonsurans (strain CBS 112818) GN=TESG_06434 PE=3 SV=1
Length = 623
Score = 311 bits (797), Expect = 2e-82, Method: Compositional matrix adjust.
Identities = 151/295 (51%), Positives = 193/295 (65%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+DDAL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMPREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CRQ GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+++ A
Sbjct: 190 DNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L +EMC+K+L +G LH YT+NL +S +L+ L L T P +P
Sbjct: 250 VKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKP 304
>D4DJK8_TRIVH (tr|D4DJK8) Methylenetetrahydrofolate reductase OS=Trichophyton
verrucosum (strain HKI 0517) GN=TRV_07376 PE=3 SV=1
Length = 623
Score = 311 bits (797), Expect = 2e-82, Method: Compositional matrix adjust.
Identities = 151/295 (51%), Positives = 193/295 (65%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+DDAL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMPREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CRQ GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+++ A
Sbjct: 190 DNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L +EMC+K+L +G LH YT+NL +S +L+ L L T P +P
Sbjct: 250 VKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKP 304
>D8Q1D9_SCHCM (tr|D8Q1D9) Methylenetetrahydrofolate reductase OS=Schizophyllum
commune (strain H4-8 / FGSC 9210) GN=SCHCODRAFT_67475
PE=3 SV=1
Length = 603
Score = 311 bits (796), Expect = 3e-82, Method: Compositional matrix adjust.
Identities = 147/308 (47%), Positives = 206/308 (66%), Gaps = 14/308 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +KI ++A D KV +SFE+FPP+T G+ NLL+R++RM P F DITW AGG
Sbjct: 1 MKISQKIQQSAKDD--KVWWSFEYFPPRTAQGLQNLLDRIERMRGLGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G+ET MHLTCTNMP EK+D AL+ K++G +N+LALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGIETCMHLTCTNMPKEKVDIALKDAKAHGCRNILALRGDPPAGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATP-EDYQNDLT 179
D++ EGGF DLV+HIR ++GDYF I + G+P+ + P E+ ++
Sbjct: 119 DEWEATEGGFVHGIDLVRHIRREYGDYFDIAVPGFPQH---------MTLPKEERDQEMK 169
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK K+DAG + I TQ+FYD IF+ + + R GIT PIVPGI PI + GF+R T
Sbjct: 170 WLKEKIDAGVNFIFTQMFYDVQIFIDWVREVRAAGITIPIVPGIAPIQTWNGFLRATSLA 229
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALA 297
KT IP M ALEP+K+++E V+A G L EMC++IL+ G + LH YT+NLEK+
Sbjct: 230 KTIIPQHFMDALEPVKNDDEKVRATGTKLVAEMCRRILSEDIGIRGLHFYTMNLEKATRM 289
Query: 298 ILKNLGLI 305
+L+ L L+
Sbjct: 290 LLEELQLV 297
>C4JG55_UNCRE (tr|C4JG55) Methylenetetrahydrofolate reductase OS=Uncinocarpus
reesii (strain UAMH 1704) GN=UREG_02453 PE=3 SV=1
Length = 625
Score = 310 bits (795), Expect = 3e-82, Method: Compositional matrix adjust.
Identities = 155/322 (48%), Positives = 206/322 (63%), Gaps = 13/322 (4%)
Query: 1 MKVIEKI-HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M + +K+ H AA P+ SFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIKDKLAHSEAAGRPS---ISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFVDITWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL++ G N+LALRGDPP
Sbjct: 58 RLSDLTAEMVNVSQSVYGLETCMHLTCTDMPREKVDWALQSAYKAGCTNILALRGDPPRE 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
++ + EGGF A+DLVK+IR K+G++F I +AGYPE G ED + +T
Sbjct: 118 KEAWAPTEGGFQYAKDLVKYIREKYGNHFDIGVAGYPE---------GCEDQEDPELLMT 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVDAG IITQ+FYD DIFL + CR+ GI PI+PGIMPI+ Y F+R + +
Sbjct: 169 HLKEKVDAGGTFIITQMFYDVDIFLDWVKRCREQGIKVPILPGIMPISTYAAFLRRSNWV 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
K ++P M ALEP K+++ AVK G L +EMC+KIL G + LH YT+NL +S +L
Sbjct: 229 KCRVPPSWMEALEPCKNDDAAVKQIGKKLVSEMCRKILDSGIRHLHFYTMNLAQSTKMVL 288
Query: 300 KNLGLIEETSIPRTRPANAIQA 321
+ L LI + P +P Q+
Sbjct: 289 EELDLIPSSETPLQKPLPWRQS 310
>F2SQ86_TRIRC (tr|F2SQ86) Methylenetetrahydrofolate reductase OS=Trichophyton
rubrum (strain ATCC MYA-4607 / CBS 118892) GN=TERG_04751
PE=3 SV=1
Length = 623
Score = 310 bits (795), Expect = 3e-82, Method: Compositional matrix adjust.
Identities = 150/295 (50%), Positives = 193/295 (65%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP E++DDAL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMPRERVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CRQ GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+++ A
Sbjct: 190 DNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L +EMC+K+L +G LH YT+NL +S +L+ L L T P +P
Sbjct: 250 VKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKP 304
>L8X3I0_9HOMO (tr|L8X3I0) Methylenetetrahydrofolate reductase OS=Rhizoctonia
solani AG-1 IA GN=AG1IA_02305 PE=3 SV=1
Length = 645
Score = 309 bits (792), Expect = 9e-82, Method: Compositional matrix adjust.
Identities = 149/308 (48%), Positives = 203/308 (65%), Gaps = 14/308 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV EKI +A ++ +SFE+FPP+T G+ NLL+R++RM P F DITW AGG
Sbjct: 1 MKVTEKIQQAEKD--GRIWWSFEYFPPRTAQGLQNLLDRIERMRGLGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G+ET MHLTCTNMP EK+D AL K+NG +N+LALRGDPP GQ
Sbjct: 59 TSDLTSELVKTCQGVIGIETCMHLTCTNMPQEKVDVALREAKANGCRNILALRGDPPSGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPE-DYQNDLT 179
+++ VEGGF DLVKHIR +H DYF I +AG+P+ + PE + + ++
Sbjct: 119 EEWTTVEGGFQHGIDLVKHIRREHDDYFDIAVAGFPQT---------IQLPEAEAKQEMQ 169
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK K DAGA+ I TQ+FYD D+F+++ R GIT PIVPGI PI + GFIR T
Sbjct: 170 WLKEKCDAGANFIFTQMFYDADMFIRWVKAARDAGITVPIVPGINPIQTWNGFIRATTLS 229
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIL--AHGFKTLHLYTLNLEKSALA 297
T IP ++M LEP K+N+E V+ G + +++C+KIL G K LH YT+NLEK
Sbjct: 230 GTDIPQDLMDILEPHKNNDEKVRELGTKIVSDLCRKILDAGIGIKGLHFYTMNLEKGTKM 289
Query: 298 ILKNLGLI 305
+L+ L L+
Sbjct: 290 LLEELNLV 297
>F2TKH4_AJEDA (tr|F2TKH4) Methylenetetrahydrofolate reductase OS=Ajellomyces
dermatitidis (strain ATCC 18188 / CBS 674.68)
GN=BDDG_06682 PE=3 SV=1
Length = 633
Score = 309 bits (791), Expect = 1e-81, Method: Compositional matrix adjust.
Identities = 154/321 (47%), Positives = 207/321 (64%), Gaps = 11/321 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A+ + SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG
Sbjct: 1 MHIKDKLAHAEAT--GRPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ G+ET MHLTCT+MP EK+D AL++ G N+LALRGDPP +
Sbjct: 59 LSELTCEMVNVAQSVYGLETCMHLTCTDMPREKVDTALQSAFKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGF A+DLVK+IR K+G++F I +AGYPE G +D + + +
Sbjct: 119 EKWEATEGGFRYAKDLVKYIRDKYGNHFDIGVAGYPE---------GCDDQDDPELLMEH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IITQ+FYD D FL + CRQ GIT PI+PGIMPI+ Y FIR + + K
Sbjct: 170 LKEKVDAGGTFIITQMFYDVDNFLTWVEKCRQKGITVPIIPGIMPIHTYAAFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP + + ALEP+K+++ AV+ G L +MCKKILA G LH YT+NL+++ IL
Sbjct: 230 IRIPPDWLEALEPVKNDDAAVRNLGKSLVADMCKKILASGIYHLHFYTMNLQQATKMILD 289
Query: 301 NLGLIEETSIPRTRPANAIQA 321
LGLI P +P Q+
Sbjct: 290 ELGLIPSHKTPLQKPLPWRQS 310
>C5GPB7_AJEDR (tr|C5GPB7) Methylenetetrahydrofolate reductase OS=Ajellomyces
dermatitidis (strain ER-3 / ATCC MYA-2586) GN=BDCG_06426
PE=3 SV=1
Length = 633
Score = 309 bits (791), Expect = 1e-81, Method: Compositional matrix adjust.
Identities = 154/321 (47%), Positives = 207/321 (64%), Gaps = 11/321 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A+ + SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG
Sbjct: 1 MHIKDKLAHAEAT--GRPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ G+ET MHLTCT+MP EK+D AL++ G N+LALRGDPP +
Sbjct: 59 LSELTCEMVNVAQSVYGLETCMHLTCTDMPREKVDTALQSAFKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGF A+DLVK+IR K+G++F I +AGYPE G +D + + +
Sbjct: 119 EKWEATEGGFRYAKDLVKYIRDKYGNHFDIGVAGYPE---------GCDDQDDPELLMEH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IITQ+FYD D FL + CRQ GIT PI+PGIMPI+ Y FIR + + K
Sbjct: 170 LKEKVDAGGTFIITQMFYDVDNFLTWVEKCRQKGITVPIIPGIMPIHTYAAFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP + + ALEP+K+++ AV+ G L +MCKKILA G LH YT+NL+++ IL
Sbjct: 230 IRIPPDWLEALEPVKNDDAAVRNLGKSLVADMCKKILASGIYHLHFYTMNLQQATKMILD 289
Query: 301 NLGLIEETSIPRTRPANAIQA 321
LGLI P +P Q+
Sbjct: 290 ELGLIPSHKTPLQKPLPWRQS 310
>C5JE18_AJEDS (tr|C5JE18) Methylenetetrahydrofolate reductase OS=Ajellomyces
dermatitidis (strain SLH14081) GN=BDBG_00602 PE=3 SV=1
Length = 633
Score = 308 bits (790), Expect = 1e-81, Method: Compositional matrix adjust.
Identities = 154/321 (47%), Positives = 207/321 (64%), Gaps = 11/321 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A+ + SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG
Sbjct: 1 MHIKDKLAHAEAT--GRPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ G+ET MHLTCT+MP EK+D AL++ G N+LALRGDPP +
Sbjct: 59 LSELTCEMVNVAQSVYGLETCMHLTCTDMPREKVDTALQSAFKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGF A+DLVK+IR K+G++F I +AGYPE G +D + + +
Sbjct: 119 EKWEATEGGFRYAKDLVKYIRDKYGNHFDIGVAGYPE---------GCDDQDDPELLMEH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IITQ+FYD D FL + CRQ GIT PI+PGIMPI+ Y FIR + + K
Sbjct: 170 LKEKVDAGGTFIITQMFYDVDNFLTWVERCRQKGITVPIIPGIMPIHTYAAFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP + + ALEP+K+++ AV+ G L +MCKKILA G LH YT+NL+++ IL
Sbjct: 230 IRIPPDWLEALEPVKNDDAAVRNLGKSLVADMCKKILASGIYHLHFYTMNLQQATKMILD 289
Query: 301 NLGLIEETSIPRTRPANAIQA 321
LGLI P +P Q+
Sbjct: 290 ELGLIPSHKTPLQKPLPWRQS 310
>F2PWP0_TRIEC (tr|F2PWP0) Methylenetetrahydrofolate reductase OS=Trichophyton
equinum (strain ATCC MYA-4606 / CBS 127.97)
GN=TEQG_05311 PE=3 SV=1
Length = 623
Score = 308 bits (790), Expect = 1e-81, Method: Compositional matrix adjust.
Identities = 150/295 (50%), Positives = 192/295 (65%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+M EK+DDAL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMSREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CRQ GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+++ A
Sbjct: 190 DNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L +EMC+K+L +G LH YT+NL +S +L+ L L T P +P
Sbjct: 250 VKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKP 304
>Q6FU20_CANGA (tr|Q6FU20) Methylenetetrahydrofolate reductase OS=Candida glabrata
(strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
NRRL Y-65) GN=CAGL0F07029g PE=3 SV=1
Length = 600
Score = 308 bits (789), Expect = 2e-81, Method: Compositional matrix adjust.
Identities = 151/327 (46%), Positives = 215/327 (65%), Gaps = 13/327 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ +K+ + P+K FSFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITQKLADRHKEKPDKATFSFEYFVPKTTQGVQNLYDRMDRMYEASLPEFIDITWNAGG 60
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP- 117
+ ++ ++ Q+ +G+ET MHLTCTNMP+ +ID+ALE ++G QN+LALRGDPP
Sbjct: 61 GRLSQLSTELVATAQSVLGLETCMHLTCTNMPISQIDEALEDAYNSGCQNILALRGDPPL 120
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
+ + + +EGGF A+DLVK+IRAK+GD+F I +AGYPE HP+ ++ D
Sbjct: 121 NAPNGWQPIEGGFNYAKDLVKYIRAKYGDHFDIGVAGYPEGHPEE---------KERHKD 171
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
L YLK K+DAG IITQ+FYD D F+++ ++ R++GI PI+PGIMPI Y F+R
Sbjct: 172 LVYLKEKIDAGGSFIITQMFYDVDNFIQWCHEVREMGIDVPIIPGIMPITTYAAFLRRAQ 231
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSAL 296
+ + KIP + LEP+KD+++ V+ G L +MC+KIL G+ K LH+YT+NLEK+ L
Sbjct: 232 WGQIKIPQAFLDVLEPVKDDDQLVRDKGSELIVDMCQKILNSGYVKHLHIYTMNLEKAPL 291
Query: 297 AILKNLGLIEETSIPRTRPANAIQAKE 323
IL+ LGL+ S P ++ ++
Sbjct: 292 IILEKLGLLPSESEVNANPLASLPWRK 318
>F8Q5A5_SERL3 (tr|F8Q5A5) Methylenetetrahydrofolate reductase OS=Serpula
lacrymans var. lacrymans (strain S7.3)
GN=SERLA73DRAFT_161762 PE=3 SV=1
Length = 605
Score = 308 bits (789), Expect = 2e-81, Method: Compositional matrix adjust.
Identities = 150/307 (48%), Positives = 200/307 (65%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +KI ++ KV +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MKISKKIDQSTKD--GKVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G+ET MHLTCTNMP EK+D AL K +G +NVLALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGMETCMHLTCTNMPKEKVDIALREAKQHGCRNVLALRGDPPQGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D++ VEGGF DLV+HI ++GDYF I +AG+P+ N L PE+ ++ Y
Sbjct: 119 DEWEAVEGGFVHGIDLVRHIHNEYGDYFDIAVAGFPQ--------NQLLPPEERDLEMKY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVD G D I TQ+FYD ++F+ + R GIT PIVPGI PI + GF+R T K
Sbjct: 171 LKEKVDEGVDFIFTQMFYDVEVFIDWVKAVRVAGITIPIVPGIAPIQTWNGFMRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T+IP M ALEP K+++E V+ G L EMC +IL G + LH YT+NLEK +
Sbjct: 231 TQIPQSFMEALEPHKNDDEKVREIGTKLVAEMCLRILKEDIGIRGLHFYTMNLEKGTKML 290
Query: 299 LKNLGLI 305
L+ L L+
Sbjct: 291 LEELNLV 297
>I4YIV3_WALSC (tr|I4YIV3) Methylenetetrahydrofolate reductase OS=Wallemia sebi
(strain ATCC MYA-4683 / CBS 633.66) GN=WALSEDRAFT_66783
PE=3 SV=1
Length = 600
Score = 308 bits (788), Expect = 2e-81, Method: Compositional matrix adjust.
Identities = 150/312 (48%), Positives = 206/312 (66%), Gaps = 10/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ EK+ AA +++ +SFEFFPP+T G+ NL++R++RM P F DITW +GG
Sbjct: 1 MKITEKL--LAAEREDRLWWSFEFFPPRTAQGMTNLVDRIERMRRLGPEFVDITWHSGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TA++T ++ K Q ++GVET MHLTCT MP EK+ +ALE K NG NVLALRGDPP GQ
Sbjct: 59 TAELTTELVKTCQASIGVETCMHLTCTGMPREKVINALEEAKKNGCTNVLALRGDPPRGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF A DLV+HIR ++GDYF + +AG+PE G+ D N++ Y
Sbjct: 119 TEWYPHPNGFTYAADLVRHIRQEYGDYFEVAVAGFPE------GNLQYKHSSDKDNEIQY 172
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQ+FYD D F+ + N R+ G+T PIVPGIMPI + GF + +
Sbjct: 173 LKEKVDAGADLIMTQMFYDVDNFIDWCNKVREAGVTVPIVPGIMPIQTWNGFQKAVQMAQ 232
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
TK+P + M LE +K+++ V+ G L ++MC+KIL G + LHLYT+NLE+ I
Sbjct: 233 TKVPQDWMDQLEAVKEDDAKVREVGTKLVSDMCRKILDANVGIRGLHLYTMNLERGPKMI 292
Query: 299 LKNLGLIEETSI 310
L+ L LI +T I
Sbjct: 293 LQELNLIPQTQI 304
>J8Q880_SACAR (tr|J8Q880) Methylenetetrahydrofolate reductase OS=Saccharomyces
arboricola (strain H-6 / AS 2.3317 / CBS 10644)
GN=SU7_1115 PE=3 SV=1
Length = 600
Score = 307 bits (787), Expect = 3e-81, Method: Compositional matrix adjust.
Identities = 150/312 (48%), Positives = 207/312 (66%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQQRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVSTAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + QVEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAESWTQVEGGFKYAKDLIKYIKSKYGDHFAIGVAGYPECHPE-------LPSKDSKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYGAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ +IP E +A LEPIKD++E V+ G +L +MC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQIRIPQEFLAQLEPIKDDDELVRDVGTNLIVQMCQKLLDSGYISHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>A1C6H3_ASPCL (tr|A1C6H3) Methylenetetrahydrofolate reductase OS=Aspergillus
clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC
3887 / NRRL 1) GN=ACLA_070260 PE=3 SV=1
Length = 619
Score = 307 bits (787), Expect = 3e-81, Method: Compositional matrix adjust.
Identities = 152/315 (48%), Positives = 201/315 (63%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M V +K+++ A +V SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHVKDKLYQNEAG--GQVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP+EK+D AL G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPLEKVDAALSAAYKAGCTNILALRGDPPRDK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + EGG A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EAWEATEGGLRYAKDLVKYIREKYGNHFDIGVGGYPEGADDNPDVDLL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ IITQ+FYDTD F+++ CR GIT PI+PGIMPI+ Y FIR + K
Sbjct: 170 LKEKVDAGSSFIITQMFYDTDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP E + ALEP+K+++ AVK G L EMC+K+LA G LH YT+NL ++ ++L
Sbjct: 230 ARIPPEWLEALEPVKNDDAAVKEIGKRLIAEMCRKLLAAGLNHLHFYTMNLAQATQSVLD 289
Query: 301 NLGLIEETSIPRTRP 315
L LI P RP
Sbjct: 290 ELKLIPSEETPLQRP 304
>B8BVS6_THAPS (tr|B8BVS6) Methylenetetrahydrofolate reductase OS=Thalassiosira
pseudonana GN=THAPSDRAFT_27273 PE=3 SV=1
Length = 383
Score = 306 bits (784), Expect = 6e-81, Method: Compositional matrix adjust.
Identities = 147/290 (50%), Positives = 199/290 (68%), Gaps = 7/290 (2%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPS-FCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
S E+FPP+T+ GV NL RMDRM+ ++ + + D+TWGAGGSTAD++L++A T G
Sbjct: 27 SLEYFPPRTDQGVKNLHARMDRMLVNTNALYTDMTWGAGGSTADLSLELALHAHKT-GHV 85
Query: 80 TMMHLTCTNM-----PVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACAR 134
+ MHLTCTNM PV+ + DAL+ G++N++ALRGDPP G+ ++ EGGF+CA
Sbjct: 86 SNMHLTCTNMEKDGDPVKAVHDALQQAYDGGIRNIVALRGDPPEGEKEWTATEGGFSCAL 145
Query: 135 DLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIIT 194
DLVK+IR GD FGI++AGYPE HP+ I EDY+ ++ YLK KVDAG D IIT
Sbjct: 146 DLVKYIRKTFGDKFGISVAGYPEGHPNRISQLSEEEDEDYKKEMDYLKEKVDAGGDFIIT 205
Query: 195 QLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPI 254
Q+F+D ++F F NDCR GITCP+VPG+M IN Y GF +MT FCKT++P + ++ I
Sbjct: 206 QMFFDAEVFKTFVNDCRTWGITCPVVPGLMCINAYPGFKKMTKFCKTRVPKSLEERMDAI 265
Query: 255 KDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGL 304
KD+ +AVK +G+ G E+ + +L G K LH YTLNLEK I LG+
Sbjct: 266 KDDADAVKKFGVEFGAEISRNLLDSGVKILHFYTLNLEKVVYGITDELGI 315
>M5G436_DACSP (tr|M5G436) Methylenetetrahydrofolate reduct OS=Dacryopinax sp.
(strain DJM 731) GN=DACRYDRAFT_21039 PE=4 SV=1
Length = 602
Score = 306 bits (784), Expect = 7e-81, Method: Compositional matrix adjust.
Identities = 144/317 (45%), Positives = 204/317 (64%), Gaps = 14/317 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ +A +V +SFE+FPP+T G+ NLL+R++RM P F DITW AGG
Sbjct: 1 MKITKKLQQAEHE--GRVWWSFEYFPPRTAPGMQNLLDRIERMRELGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T ++ + Q +G+ET MHLTCTNMP K+D AL+ K G +NVLALRGDPP GQ
Sbjct: 59 TSELTSELVRCCQRDLGIETCMHLTCTNMPAAKVDIALKEAKQWGCRNVLALRGDPPFGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+++ + E GF DLVKHIRA +GDYF + +AG+PEAH D ++++ +
Sbjct: 119 EQWTKTEDGFEHGIDLVKHIRAGYGDYFDVAVAGFPEAH----------NRHDREDEMKF 168
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+K+DAG D I TQ+F+D D+F+ + R GITCPIVPGIMPI + GF R T K
Sbjct: 169 LKNKIDAGVDFIFTQMFWDVDLFIDWVKAVRAAGITCPIVPGIMPIQTWNGFQRATSLAK 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
P ++AALEP K+++E V+ G + +MC+KILA G + LH YT+NLE+ +
Sbjct: 229 ISTPPALLAALEPYKNDDEKVREIGTQIVADMCRKILAADIGIRGLHFYTMNLERGTRML 288
Query: 299 LKNLGLIEETSIPRTRP 315
L+ L + + R P
Sbjct: 289 LEALNFVPHIEVVRPLP 305
>M2R3N4_CERSU (tr|M2R3N4) Methylenetetrahydrofolate reductase OS=Ceriporiopsis
subvermispora B GN=CERSUDRAFT_112818 PE=3 SV=1
Length = 605
Score = 306 bits (784), Expect = 7e-81, Method: Compositional matrix adjust.
Identities = 146/307 (47%), Positives = 203/307 (66%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M++ +KI A D +V +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MRISKKIEAAQKED--RVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFVDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T ++ K Q+ +G+ET MHLTCTNMP EK+D AL K NG +NVLALRGDPP G+
Sbjct: 59 TSELTSELVKTCQSLIGIETCMHLTCTNMPKEKVDIALREAKQNGCRNVLALRGDPPMGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D++ VEGGF+ DLV+HIR ++GDYF I +AG+P+ + PE+ ++ Y
Sbjct: 119 DEWEAVEGGFSHGIDLVRHIRKEYGDYFDIAVAGFPQ--------HVTLPPEERDLEMKY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+D GA+ I TQ+FYD +IF+K+ R GIT PIVPGI PI + GF++ T
Sbjct: 171 LKEKIDGGANFIFTQMFYDVEIFIKWVRAVRAAGITVPIVPGIAPIQTFNGFMKSTVLSG 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T IP + ALEP K+N+E V+ G L +MC++IL G + LH YT+NLE+ +
Sbjct: 231 TTIPQATLDALEPYKNNDEKVREIGTKLVADMCRRILKEDIGIRGLHFYTMNLERGTRML 290
Query: 299 LKNLGLI 305
L+ L L+
Sbjct: 291 LEELNLV 297
>E6ZP86_SPORE (tr|E6ZP86) Methylenetetrahydrofolate reductase OS=Sporisorium
reilianum (strain SRZ2) GN=sr15499 PE=3 SV=1
Length = 649
Score = 306 bits (783), Expect = 9e-81, Method: Compositional matrix adjust.
Identities = 150/306 (49%), Positives = 196/306 (64%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
K+ KI A A ++ +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 17 WKITNKI--AKAEKEGRIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGR 74
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T + K + +G+ET MHLTCTNMP EKID AL+ K G +N+LALRGDPP GQ
Sbjct: 75 TSDLTASLVKTVHTYIGLETCMHLTCTNMPREKIDTALKEAKEFGCRNILALRGDPPAGQ 134
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF A+ LV++IR +GDYF I +AG+PE HP+A+ PE +L
Sbjct: 135 SEWEPHAAGFTSAKQLVEYIRENYGDYFAIAVAGFPEGHPEAVDG-----PE---KELER 186
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGAD I TQ+FYD DIF K+ D R GITCPIVPG+MPI Y GF R T
Sbjct: 187 LKEKIDAGADFIFTQMFYDFDIFAKWVKDVRAAGITCPIVPGVMPIQTYGGFQRATARFG 246
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
T +P AL+P+KD+++ V+ G L EMCKKI+ G LH+YT+NLEK + +
Sbjct: 247 TLVPQYFHDALDPVKDDDQKVRDVGTRLVGEMCKKIVGTGLGISGLHIYTMNLEKGSRML 306
Query: 299 LKNLGL 304
L LGL
Sbjct: 307 LDYLGL 312
>G4TUD6_PIRID (tr|G4TUD6) Methylenetetrahydrofolate reductase OS=Piriformospora
indica (strain DSM 11827) GN=PIIN_08899 PE=3 SV=1
Length = 599
Score = 305 bits (782), Expect = 1e-80, Method: Compositional matrix adjust.
Identities = 144/307 (46%), Positives = 202/307 (65%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M++ EKI +A N+V +SFE+FPP+T G NL++R++RM P F DITW AGG
Sbjct: 1 MRITEKIEKAEKQ--NRVWWSFEYFPPRTAQGFQNLVDRIERMRHLGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T ++ K Q+ +G+ET MHLTCTNMP EK+D AL KS+G +N+LALRGDPP GQ
Sbjct: 59 TSELTSEMVKTCQSLLGIETCMHLTCTNMPSEKVDIALREAKSHGCRNILALRGDPPAGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D++ V+GGF DLV+HIR +GDYF I +AG+PE + + + E+ Q +L Y
Sbjct: 119 DEWTAVDGGFVHGIDLVRHIRKNYGDYFEIAVAGFPE--------HAMLSEEEQQVELQY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGA I TQ+FYD D+F+++ + R+ GIT PIVPGI PI + GF++ T K
Sbjct: 171 LKEKIDAGASFIFTQMFYDLDLFVRWVHSVRKAGITVPIVPGINPIQTWNGFMKATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
IP + LEP K+N+E V+ G L ++C+ IL G + LH YT+NLEK +
Sbjct: 231 ITIPQSYLDVLEPHKNNDEKVRELGTKLVADLCRGILNAGLGIRGLHFYTMNLEKGTRML 290
Query: 299 LKNLGLI 305
L+ L +
Sbjct: 291 LEELSFV 297
>J3K5S4_COCIM (tr|J3K5S4) Methylenetetrahydrofolate reductase OS=Coccidioides
immitis (strain RS) GN=CIMG_08202 PE=3 SV=1
Length = 629
Score = 305 bits (781), Expect = 1e-80, Method: Compositional matrix adjust.
Identities = 153/322 (47%), Positives = 202/322 (62%), Gaps = 13/322 (4%)
Query: 1 MKVIEKI-HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M V EK+ H A+ P+ SFEFFPPKT GV NL +RMDRM P+F DITWGAGG
Sbjct: 1 MHVKEKLAHSEASGRPS---ISFEFFPPKTAQGVQNLYDRMDRMHGLGPAFIDITWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ G N+LALRGDPP
Sbjct: 58 RLSDLTCEMVNVAQSVYGLETCMHLTCTDMPREKVDWALQCAHKAGCTNILALRGDPPRE 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
++ + EGGF A+DLVK+IR K+G++F I +AGYPE G ED + +
Sbjct: 118 KESWAPTEGGFRYAKDLVKYIREKYGNHFDIGVAGYPE---------GCEDEEDPETLMK 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVDAG IITQ+FYD DIFL + CR+ GI PI+PGIMPI+ Y F+R + +
Sbjct: 169 HLKEKVDAGGTFIITQMFYDVDIFLDWVKRCRENGIQVPILPGIMPISTYASFLRRSNWV 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
K K+P M ALEP+K+++ AVK G L MC+KIL G + LH YT+NL ++ +L
Sbjct: 229 KCKVPESWMEALEPVKNDDAAVKQIGKKLVANMCQKILDSGIRHLHFYTMNLAQATKMVL 288
Query: 300 KNLGLIEETSIPRTRPANAIQA 321
+ L LI P +P Q+
Sbjct: 289 EELKLIPSYETPLQKPLPWRQS 310
>E9DEV7_COCPS (tr|E9DEV7) Methylenetetrahydrofolate reductase OS=Coccidioides
posadasii (strain RMSCC 757 / Silveira) GN=CPSG_08357
PE=3 SV=1
Length = 629
Score = 305 bits (781), Expect = 1e-80, Method: Compositional matrix adjust.
Identities = 153/322 (47%), Positives = 202/322 (62%), Gaps = 13/322 (4%)
Query: 1 MKVIEKI-HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M V EK+ H A+ P+ SFEFFPPKT GV NL +RMDRM P+F DITWGAGG
Sbjct: 1 MHVKEKLAHSEASGRPS---ISFEFFPPKTAQGVQNLYDRMDRMHGLGPAFIDITWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ G N+LALRGDPP
Sbjct: 58 RLSDLTCEMVNVAQSVYGLETCMHLTCTDMPREKVDWALQCAHKAGCTNILALRGDPPRE 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
++ + EGGF A+DLVK+IR K+G++F I +AGYPE G ED + +
Sbjct: 118 KESWAPTEGGFRYAKDLVKYIREKYGNHFDIGVAGYPE---------GCEDEEDPETLMK 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVDAG IITQ+FYD DIFL + CR+ GI PI+PGIMPI+ Y F+R + +
Sbjct: 169 HLKEKVDAGGTFIITQMFYDVDIFLDWVKRCRENGIQVPILPGIMPISTYASFLRRSNWV 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
K K+P M ALEP+K+++ AVK G L MC+KIL G + LH YT+NL ++ +L
Sbjct: 229 KCKVPESWMEALEPVKNDDAAVKQIGKKLVANMCQKILDSGIRHLHFYTMNLAQATKMVL 288
Query: 300 KNLGLIEETSIPRTRPANAIQA 321
+ L LI P +P Q+
Sbjct: 289 EELKLIPSYETPLQKPLPWRQS 310
>C5PJM0_COCP7 (tr|C5PJM0) Methylenetetrahydrofolate reductase OS=Coccidioides
posadasii (strain C735) GN=CPC735_022180 PE=3 SV=1
Length = 629
Score = 305 bits (781), Expect = 1e-80, Method: Compositional matrix adjust.
Identities = 153/322 (47%), Positives = 202/322 (62%), Gaps = 13/322 (4%)
Query: 1 MKVIEKI-HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M V EK+ H A+ P+ SFEFFPPKT GV NL +RMDRM P+F DITWGAGG
Sbjct: 1 MHVKEKLAHSEASGRPS---ISFEFFPPKTAQGVQNLYDRMDRMHGLGPAFIDITWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ G N+LALRGDPP
Sbjct: 58 RLSDLTCEMVNVAQSVYGLETCMHLTCTDMPREKVDWALQCAHKAGCTNILALRGDPPRE 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
++ + EGGF A+DLVK+IR K+G++F I +AGYPE G ED + +
Sbjct: 118 KESWAPTEGGFRYAKDLVKYIREKYGNHFDIGVAGYPE---------GCEDEEDPETLMK 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVDAG IITQ+FYD DIFL + CR+ GI PI+PGIMPI+ Y F+R + +
Sbjct: 169 HLKEKVDAGGTFIITQMFYDVDIFLDWVKRCRENGIQVPILPGIMPISTYASFLRRSNWV 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
K K+P M ALEP+K+++ AVK G L MC+KIL G + LH YT+NL ++ +L
Sbjct: 229 KCKVPESWMEALEPVKNDDAAVKQIGKKLVANMCQKILDSGIRHLHFYTMNLAQATKMVL 288
Query: 300 KNLGLIEETSIPRTRPANAIQA 321
+ L LI P +P Q+
Sbjct: 289 EELKLIPSYETPLQKPLPWRQS 310
>M9MW94_ASHGS (tr|M9MW94) FAAR170Wp OS=Ashbya gossypii FDAG1 GN=FAGOS_FAAR170W
PE=4 SV=1
Length = 603
Score = 305 bits (781), Expect = 2e-80, Method: Compositional matrix adjust.
Identities = 154/322 (47%), Positives = 207/322 (64%), Gaps = 16/322 (4%)
Query: 1 MKVIEKIHE---AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGA 57
M++ +K+ + AAA + K FSFEFF PKT GV NL +RMDRM P F DITW A
Sbjct: 1 MRISQKLKQRAGAAAEEQPKASFSFEFFVPKTLQGVQNLYDRMDRMYQTQPEFIDITWNA 60
Query: 58 GGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP 117
GG + T ++ Q +G+ET MHLTCTNM +D+ALE G +N+LALRGDPP
Sbjct: 61 GGRLSQRTSELVATSQGVLGLETCMHLTCTNMSTALVDEALERAYEAGCENILALRGDPP 120
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
Q + GGF A+DLV HIRA++GD+F + +AGYPE H +A G+ +
Sbjct: 121 L-QGTWEPCAGGFRYAKDLVAHIRARYGDHFDVGVAGYPEGHEEASGAELIG-------- 171
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
YLK KVDAGAD IITQ+FYD D+FLK+ + R GI+ PI+PGIMPI +Y +R
Sbjct: 172 --YLKEKVDAGADFIITQMFYDADLFLKWCDAVRAAGISVPIIPGIMPITSYAALLRRAK 229
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSAL 296
+C+ ++P E + LEP+KD+++AV+ G L +MC+KILA G T LHLYT+NLE+++L
Sbjct: 230 WCQVRLPPEFLERLEPVKDDDQAVREIGTVLVADMCRKILASGHVTHLHLYTMNLERASL 289
Query: 297 AILKNLGLIEETSIP-RTRPAN 317
IL+ L LI+ R RP+
Sbjct: 290 MILERLQLIDTGGAGVRRRPST 311
>R9P122_9BASI (tr|R9P122) Methylenetetrahydrofolate reductase OS=Pseudozyma
hubeiensis SY62 GN=PHSY_002365 PE=4 SV=1
Length = 651
Score = 305 bits (780), Expect = 2e-80, Method: Compositional matrix adjust.
Identities = 147/306 (48%), Positives = 197/306 (64%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
K+ KI A A ++ +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 17 WKITNKI--AKAEKEGRIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGR 74
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T + K + +G+ET MHLTCTNMP EKID AL+ K G +N+LALRGDPP GQ
Sbjct: 75 TSDLTASLVKTVHTYIGLETCMHLTCTNMPREKIDTALKEAKEFGCRNILALRGDPPAGQ 134
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF+ A++LV++IR ++GDYF I +AG+PE HP+A+ L +L
Sbjct: 135 SEWEPHAAGFSRAKELVEYIREQYGDYFAIAVAGFPEGHPEAVDGADL--------ELQR 186
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGAD I TQ+FYD DIF K+ D R GI CPI+PG+MPI Y GF R T
Sbjct: 187 LKEKIDAGADFIFTQMFYDFDIFAKWVKDVRAAGINCPIIPGVMPIQTYGGFQRATARFG 246
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
T +P AL+P+KD+++ V+ G L EMCKKI+ G LH+YT+NLEK + +
Sbjct: 247 TLVPQYFHDALDPVKDDDQKVREIGTRLVGEMCKKIVGTGLGISGLHIYTMNLEKGSRML 306
Query: 299 LKNLGL 304
L LGL
Sbjct: 307 LDYLGL 312
>D8LT26_ECTSI (tr|D8LT26) Methylenetetrahydrofolate reductase OS=Ectocarpus
siliculosus GN=Esi_0078_0011 PE=3 SV=1
Length = 299
Score = 305 bits (780), Expect = 2e-80, Method: Compositional matrix adjust.
Identities = 147/288 (51%), Positives = 193/288 (67%), Gaps = 11/288 (3%)
Query: 1 MKVIEKIHEA-AASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
MK+I+KI +A A +P +SFEFFPPKT GV NL RM+RM P F D+TWGAGG
Sbjct: 1 MKIIDKIQQAMEAKEP---FYSFEFFPPKTSAGVENLSARMERMATLEPLFVDVTWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
ST+D+TL I+ Q +GVE +MHLTCTN+ VE+I AL + G+QN+LALRGDP G
Sbjct: 58 STSDLTLAISANAQKYLGVEVLMHLTCTNLKVEEIKGALNKAREAGIQNILALRGDPAKG 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDA-IGSNGLATPEDYQN-- 176
+ EGG A DLV+ IR +HGDYFG+ +AG+PE H D G+ +D ++
Sbjct: 118 LGNWEAAEGGLRHAIDLVRLIREEHGDYFGVAVAGHPEGHVDGRTGAEEGGQDDDRRDEG 177
Query: 177 ----DLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGF 232
+L LK KVDAGAD +ITQ FYDT+ FL + CR++GITCPI+PGIM I NY F
Sbjct: 178 WEALELKRLKEKVDAGADFVITQFFYDTEAFLSYVKRCREVGITCPIIPGIMAIQNYNAF 237
Query: 233 IRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG 280
RMT FC+T++P+++ AL+PI +++AVK YG+ LG MCK + G
Sbjct: 238 ARMTDFCETRVPSDVREALKPITSDDDAVKDYGVDLGIRMCKALTEAG 285
>M9M1W1_9BASI (tr|M9M1W1) 5,10-methylenetetrahydrofolate reductase OS=Pseudozyma
antarctica T-34 GN=PANT_27c00063 PE=4 SV=1
Length = 652
Score = 304 bits (779), Expect = 2e-80, Method: Compositional matrix adjust.
Identities = 148/306 (48%), Positives = 199/306 (65%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
K+ KI A A ++ +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 18 WKITNKI--AKAEKEGRIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGR 75
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T + K + +G+ET MHLTCTNMP +KID AL+ K G +N+LALRGDPP GQ
Sbjct: 76 TSDLTASLVKTVHTYIGLETCMHLTCTNMPRDKIDTALKEAKEFGCRNILALRGDPPAGQ 135
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF A++LV++IR ++GDYF I +AG+PE HP+A+ PE +L
Sbjct: 136 SEWEPHAAGFTQAQELVEYIRQQYGDYFAIAVAGFPEGHPEAVDG-----PE---KELER 187
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSK+DAGAD I TQ+FYD DIF K+ D R GITCPI+PG+MPI Y GF R T
Sbjct: 188 LKSKIDAGADFIFTQMFYDFDIFAKWVKDVRAAGITCPIIPGVMPIQTYGGFQRATARFG 247
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
T +P AL+P+KD+++ V+ G L +MCKKI+ G LH+YT+NLEK + +
Sbjct: 248 TLVPQYFHDALDPVKDDDQKVREIGTRLVGDMCKKIVGTGLGISGLHIYTMNLEKGSRML 307
Query: 299 LKNLGL 304
L LGL
Sbjct: 308 LDYLGL 313
>A9UZU5_MONBE (tr|A9UZU5) Methylenetetrahydrofolate reductase OS=Monosiga
brevicollis GN=32490 PE=3 SV=1
Length = 332
Score = 304 bits (778), Expect = 3e-80, Method: Compositional matrix adjust.
Identities = 153/325 (47%), Positives = 208/325 (64%), Gaps = 23/325 (7%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
K+ +++ E +A V SFEFFPP+T+DGV +L+ R+ R P F D+TWGAGGS
Sbjct: 4 FKISDRLQELSAKGEKFV--SFEFFPPRTDDGVTSLMSRIQRYNDQQPLFMDMTWGAGGS 61
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+TLD+ +M G MHLTCTNMP EKID AL+ + G++N++ALRGDPP G+
Sbjct: 62 TSDLTLDLCTRMVKECGANANMHLTCTNMPSEKIDIALKGARDAGIRNIVALRGDPPAGE 121
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIG---------------- 164
+ + VEGG++CA DLVKHIR +HGD+F I ++GYPE HP+AI
Sbjct: 122 EAWEAVEGGYSCALDLVKHIRKEHGDFFSIAVSGYPEGHPNAITKVQDEAELTESERERV 181
Query: 165 ---SNGLATPE--DYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPI 219
+GL D+Q ++ YLK+KVDAGADLIITQ+ +D ++ F C+ GI P+
Sbjct: 182 IEMEDGLYVCRDGDFQKEMEYLKAKVDAGADLIITQMVFDAPVYGAFLKACKAYGINIPV 241
Query: 220 VPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH 279
VPGIM I N GF RMT FCK++ PA + AA+E D++EA++ + G ++C+ + A
Sbjct: 242 VPGIMCIQNAGGFKRMTAFCKSRTPAALRAAVEAAGDDKEAIRKVAVEHGAQLCRDLQAA 301
Query: 280 GFKTLHLYTLNLEKSALAILKNLGL 304
G LH YTLNLEK LAIL L L
Sbjct: 302 GAPGLHFYTLNLEKVTLAILDALNL 326
>B0CU22_LACBS (tr|B0CU22) Methylenetetrahydrofolate reductase OS=Laccaria bicolor
(strain S238N-H82 / ATCC MYA-4686) GN=LACBIDRAFT_182479
PE=3 SV=1
Length = 602
Score = 304 bits (778), Expect = 3e-80, Method: Compositional matrix adjust.
Identities = 147/308 (47%), Positives = 202/308 (65%), Gaps = 14/308 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +KI ++A +D K+ +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MKITQKIQQSANND--KIWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T ++ K Q +G+ET MHLTCTNMP EK+D AL K +G +NVLALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGMETCMHLTCTNMPKEKVDIALREAKQHGCRNVLALRGDPPSGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQN-DLT 179
D++ VEGGF DLV+HIR +GDYF I +AG+P+ +A P D ++ ++
Sbjct: 119 DEWEAVEGGFVHGIDLVRHIRRDYGDYFDIAVAGFPQH---------MALPPDERDQEIQ 169
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVDAG I TQ+FYD +F+ + R GIT PIVPGI PI + GF R T
Sbjct: 170 WLKEKVDAGVAFIFTQMFYDVQLFIDWVKAIRAAGITIPIVPGIAPIQTWNGFQRATSLA 229
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALA 297
K +P + ALEPIK+++E V+ G L +MC++IL G + LH YT+NLEK
Sbjct: 230 KIVVPQSFLDALEPIKNDDEKVREVGTRLVADMCRRILKEDIGIRGLHFYTMNLEKGTKM 289
Query: 298 ILKNLGLI 305
+L+ L L+
Sbjct: 290 LLEELNLV 297
>E0XYM8_9CHLR (tr|E0XYM8) Methylenetetrahydrofolate reductase OS=uncultured
Chloroflexi bacterium HF0770_09E03 PE=3 SV=1
Length = 589
Score = 303 bits (777), Expect = 5e-80, Method: Compositional matrix adjust.
Identities = 148/315 (46%), Positives = 199/315 (63%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ + I++ K +SFEFFPPK++ + NL R+DRM + P++ DITWGAGGS
Sbjct: 1 MKISDTINDFKTQ--GKTFYSFEFFPPKSDYALDNLYSRIDRMASLQPAYIDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TA TL+++K +Q G+E MMHLTCTNMPV I+ L K NGL N+LALRGDPP G
Sbjct: 59 TAKRTLEMSKTIQKYFGLEVMMHLTCTNMPVSSINKVLINAKENGLSNILALRGDPPDGA 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ E GF DLV++IR GD F + + GYP++H + D+ D++Y
Sbjct: 119 VEWENNEKGFNYGIDLVRYIRKAFGDDFFLGVGGYPDSHQEQT---------DFDLDISY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+++++TQLFYD D FL F + C IGI PI+PGIMPI+NY FI+ T FC
Sbjct: 170 LKEKVDAGSNIVVTQLFYDVDKFLVFRDKCSAIGIHVPIIPGIMPIHNYSRFIKFTQFCD 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P + LE +K ++ +V YGI GT MC+K++A G LH YTLNLE S IL+
Sbjct: 230 VTVPDSVSKTLESLKHDDSSVIHYGIEQGTAMCEKLIAEGVPGLHFYTLNLEHSVSRILE 289
Query: 301 NLGLIEETSIPRTRP 315
+LGL R P
Sbjct: 290 SLGLASVQGSARELP 304
>H2ANE8_KAZAF (tr|H2ANE8) Methylenetetrahydrofolate reductase OS=Kazachstania
africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 /
CECT 1963 / NBRC 1671 / NRRL Y-8276) GN=KAFR0A04630 PE=3
SV=1
Length = 598
Score = 303 bits (776), Expect = 5e-80, Method: Compositional matrix adjust.
Identities = 153/328 (46%), Positives = 211/328 (64%), Gaps = 17/328 (5%)
Query: 1 MKVIEKI--HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGA 57
MK+ EK+ H+ S P +SFE+F PKT GV NL +RMD+M S P F DITW A
Sbjct: 1 MKITEKLQQHQEVCSKP---TYSFEYFVPKTTQGVQNLYDRMDKMYQSSLPLFIDITWNA 57
Query: 58 GGST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDP 116
GG T + ++ ++ Q+ +G+ET MHLTCTNM + IDDALE+ ++G QN+LALRGDP
Sbjct: 58 GGGTLSKLSTELVSTSQSVLGLETCMHLTCTNMEISMIDDALESAYNSGCQNILALRGDP 117
Query: 117 PHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQN 176
P + EGGFA A+DL+ +IR K+GDYF I +AGYPE HP+ P +N
Sbjct: 118 PRDAVNWQPTEGGFAYAKDLISYIRCKYGDYFDIGVAGYPEGHPEE--------PNKLKN 169
Query: 177 DLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMT 236
L YLK KVDAGA+ I+TQ+FYD D F+++ + R+ GI PI+PGIMPI Y F+R
Sbjct: 170 -LKYLKEKVDAGANFIVTQMFYDVDNFIQWCKEVREFGIDVPIIPGIMPITGYAAFLRRA 228
Query: 237 GFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSA 295
+ + IP A L+PIKDN+E V+ G L EMC+K+L+ G+ LH+YT+NLEK++
Sbjct: 229 SWGQINIPKYFFALLDPIKDNDELVREIGTKLVVEMCRKLLSSGYINHLHIYTMNLEKAS 288
Query: 296 LAILKNLGLIEETSIPRTRPANAIQAKE 323
L IL+ L L+ + T P + + ++
Sbjct: 289 LMILEQLDLLPTENEYLTEPISMLPWRK 316
>F0U6Q8_AJEC8 (tr|F0U6Q8) Methylenetetrahydrofolate reductase OS=Ajellomyces
capsulata (strain H88) GN=HCEG_00849 PE=3 SV=1
Length = 633
Score = 303 bits (776), Expect = 5e-80, Method: Compositional matrix adjust.
Identities = 149/315 (47%), Positives = 204/315 (64%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A+ + SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG
Sbjct: 1 MHIKDKLAHAEAT--GRPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ G+ET MHLTCT+MP EK+D A+++ G N+LALRGDPP +
Sbjct: 59 LSELTCEMVNVAQSVYGLETCMHLTCTDMPREKVDAAIQSAFKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ +EGGF A+DLVK+IR K+G++F I +AGYPE D + L + +
Sbjct: 119 EKWEAIEGGFRYAKDLVKYIRDKYGNHFDIGVAGYPEGCDDQDDPDLL---------MQH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IITQ+FYD D FL + N CR+ GIT PI+PGIMPI+ Y FIR + + K
Sbjct: 170 LKEKVDAGGTFIITQMFYDVDNFLAWVNKCRENGITVPIIPGIMPIHTYAAFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP + + ALEP+K+++ AV+ G L MC+KILA G LH YT+NL+++ +L
Sbjct: 230 IRIPPDWLEALEPVKNDDAAVRNLGKSLVANMCRKILAAGIYHLHFYTMNLQQATKMVLG 289
Query: 301 NLGLIEETSIPRTRP 315
L LI P +P
Sbjct: 290 ELELIPSHKTPLQKP 304
>C0NNE8_AJECG (tr|C0NNE8) Methylenetetrahydrofolate reductase OS=Ajellomyces
capsulata (strain G186AR / H82 / ATCC MYA-2454 / RMSCC
2432) GN=HCBG_04275 PE=3 SV=1
Length = 633
Score = 303 bits (776), Expect = 5e-80, Method: Compositional matrix adjust.
Identities = 149/315 (47%), Positives = 204/315 (64%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A+ + SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG
Sbjct: 1 MHIKDKLAHAEAT--GRPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ G+ET MHLTCT+MP EK+D A+++ G N+LALRGDPP +
Sbjct: 59 LSELTCEMVNVAQSVYGLETCMHLTCTDMPREKVDAAIQSAFKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ +EGGF A+DLVK+IR K+G++F I +AGYPE D + L + +
Sbjct: 119 EKWEAIEGGFRYAKDLVKYIRDKYGNHFDIGVAGYPEGCDDQDDPDLL---------MQH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IITQ+FYD D FL + N CR+ GIT PI+PGIMPI+ Y FIR + + K
Sbjct: 170 LKEKVDAGGTFIITQMFYDVDNFLAWVNKCRENGITVPIIPGIMPIHTYAAFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP + + ALEP+K+++ AV+ G L MC+KILA G LH YT+NL+++ +L
Sbjct: 230 IRIPPDWLEALEPVKNDDAAVRNLGKSLVANMCRKILAAGIYHLHFYTMNLQQATKMVLG 289
Query: 301 NLGLIEETSIPRTRP 315
L LI P +P
Sbjct: 290 ELELIPSHKTPLQKP 304
>C5E412_ZYGRC (tr|C5E412) Methylenetetrahydrofolate reductase
OS=Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732
/ NBRC 1130 / NCYC 568 / NRRL Y-229) GN=ZYRO0E01870g
PE=3 SV=1
Length = 599
Score = 303 bits (775), Expect = 7e-80, Method: Compositional matrix adjust.
Identities = 149/316 (47%), Positives = 205/316 (64%), Gaps = 16/316 (5%)
Query: 1 MKVIEKI--HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGA 57
M++ EK+ H + ++ P FSFE+F PKT GV NL +RMDRM + P F D+TW A
Sbjct: 1 MRISEKLQNHRSKSTKP---TFSFEYFVPKTTQGVQNLYDRMDRMYQSTLPQFIDVTWNA 57
Query: 58 GGST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDP 116
GG + +T D+ + Q+ +G+ET MHLTCTNMPV +IDDALE+ + +G QN+LALRGDP
Sbjct: 58 GGGVLSQLTTDLVETSQSVLGLETCMHLTCTNMPVSQIDDALESARLSGCQNILALRGDP 117
Query: 117 PHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQN 176
P D + VEGGF A+DLV++IR K+GDYF I +AGYPE HP+ G D +
Sbjct: 118 PVNSDSWQPVEGGFQYAKDLVRYIRDKYGDYFDIGVAGYPEGHPETAG--------DDET 169
Query: 177 DLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMT 236
L +LK KVDAGA+ IITQ+FYD D+F+K+ R G+ P++PGIMPI Y F+R
Sbjct: 170 LLDHLKEKVDAGANFIITQMFYDADLFIKWCQRVRAKGVDVPLIPGIMPITTYAAFLRRA 229
Query: 237 GFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSA 295
+C IP E L+PIKD+++ V+ G L +C+K+L G+ + LH+YT+NLEK+
Sbjct: 230 NWCDVHIPQEYFDRLDPIKDDDQLVREVGTDLIVSLCQKLLDSGYVSHLHIYTMNLEKAP 289
Query: 296 LAILKNLGLIEETSIP 311
IL + L+ P
Sbjct: 290 QMILDRMELLPSHDEP 305
>Q75EA7_ASHGO (tr|Q75EA7) Methylenetetrahydrofolate reductase OS=Ashbya gossypii
(strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
Y-1056) GN=AGOS_AAR170W PE=3 SV=2
Length = 603
Score = 302 bits (774), Expect = 9e-80, Method: Compositional matrix adjust.
Identities = 153/322 (47%), Positives = 206/322 (63%), Gaps = 16/322 (4%)
Query: 1 MKVIEKIHE---AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGA 57
M++ +K+ + AA + K FSFEFF PKT GV NL +RMDRM P F DITW A
Sbjct: 1 MRISQKLKQRAGAADEEQPKASFSFEFFVPKTLQGVQNLYDRMDRMYQTQPEFIDITWNA 60
Query: 58 GGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP 117
GG + T ++ Q +G+ET MHLTCTNM +D+ALE G +N+LALRGDPP
Sbjct: 61 GGRLSQRTSELVATSQGVLGLETCMHLTCTNMSTALVDEALERAYEAGCENILALRGDPP 120
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
Q + GGF A+DLV HIRA++GD+F + +AGYPE H +A G+ +
Sbjct: 121 L-QGTWEPCAGGFRYAKDLVAHIRARYGDHFDVGVAGYPEGHEEASGAELIG-------- 171
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
YLK KVDAGAD IITQ+FYD D+FLK+ + R GI+ PI+PGIMPI +Y +R
Sbjct: 172 --YLKEKVDAGADFIITQMFYDADLFLKWCDAVRAAGISVPIIPGIMPITSYAALLRRAK 229
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSAL 296
+C+ ++P E + LEP+KD+++AV+ G L +MC+KILA G T LHLYT+NLE+++L
Sbjct: 230 WCQVRLPPEFLERLEPVKDDDQAVREIGTVLVADMCRKILASGHVTHLHLYTMNLERASL 289
Query: 297 AILKNLGLIEETSIP-RTRPAN 317
IL+ L LI+ R RP+
Sbjct: 290 MILERLQLIDTGGAGVRRRPST 311
>J4TZ22_SACK1 (tr|J4TZ22) Methylenetetrahydrofolate reductase OS=Saccharomyces
kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS
8840 / NBRC 1802 / NCYC 2889) GN=YGL125W PE=3 SV=1
Length = 600
Score = 302 bits (774), Expect = 1e-79, Method: Compositional matrix adjust.
Identities = 148/312 (47%), Positives = 206/312 (66%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALESAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
D + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DTDSWTPVEGGFLYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDAKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + ++ R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFISWCSEVRAAGMAVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP ++ LEPIKD++E V+ G +L +MC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQAFLSQLEPIKDDDELVRDIGTNLIVQMCQKLLNSGYISHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>K0TG67_THAOC (tr|K0TG67) Methylenetetrahydrofolate reductase OS=Thalassiosira
oceanica GN=THAOC_09218 PE=3 SV=1
Length = 409
Score = 302 bits (773), Expect = 1e-79, Method: Compositional matrix adjust.
Identities = 143/313 (45%), Positives = 204/313 (65%), Gaps = 30/313 (9%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPS-FCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
S E+FPP+TE GV NL RM+RM ++ + + D+TWGAGGSTA+++LD+A T G
Sbjct: 29 SLEYFPPRTEQGVKNLHARMERMKTNTTALYTDMTWGAGGSTAELSLDLALHAHRT-GHV 87
Query: 80 TMMHLTCTNM-----PVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACAR 134
+ +HLTCTNM PV+ + +AL+ G++N++ALRGDPP G D++ EGGFACA
Sbjct: 88 SNLHLTCTNMEKDGDPVKAVREALQAAYDGGIRNIVALRGDPPEGSDEWTAAEGGFACAL 147
Query: 135 DLVKHIRAKHGDYFGITIAGYPEAHPDAI-----------------------GSNGLATP 171
DLV++IR + GD FGI++AGYPE HP+ I G +
Sbjct: 148 DLVRYIRKEFGDSFGISVAGYPEGHPNRISQLTDEEAANMSDSEKGRCCTHDGITYVCKD 207
Query: 172 EDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKG 231
+DY+ ++ YLK KVDAG D IITQ+F+D ++F F DCR+ GI CP+VPG+M IN Y G
Sbjct: 208 DDYKKEMDYLKEKVDAGGDFIITQMFFDAEVFKTFVKDCREWGINCPVVPGLMCINAYPG 267
Query: 232 FIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNL 291
F +MT FCKT++P ++ ++ +KD+ +AVK +G+ G+E+C+ +L G + LH YTLNL
Sbjct: 268 FKKMTKFCKTRVPKDLGEKMDAMKDDPDAVKKFGVTFGSEICRSLLDSGVEILHFYTLNL 327
Query: 292 EKSALAILKNLGL 304
EK I +LG+
Sbjct: 328 EKVVYGITDDLGI 340
>Q4P5K1_USTMA (tr|Q4P5K1) Methylenetetrahydrofolate reductase OS=Ustilago maydis
(strain 521 / FGSC 9021) GN=UM04612.1 PE=3 SV=1
Length = 650
Score = 302 bits (773), Expect = 1e-79, Method: Compositional matrix adjust.
Identities = 146/306 (47%), Positives = 196/306 (64%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
K+ KI A A ++ +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 17 WKITNKI--AKAEKEGRIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGR 74
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T + K + +G+ET MHLTCTNMP EKID AL+ K G +N+LALRGDPP GQ
Sbjct: 75 TSDLTASLVKTVHTYIGLETCMHLTCTNMPREKIDTALKEAKEFGCRNILALRGDPPAGQ 134
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF A++LV++IR ++GDYF I +AG+PE HP+AI L +L
Sbjct: 135 SEWEPHAAGFTRAKELVEYIREQYGDYFAIAVAGFPEGHPEAIDGPEL--------ELER 186
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K++AGAD I TQ+FYD DIF K+ D R GI CPI+PG+MPI Y GF R T
Sbjct: 187 LKEKIEAGADFIFTQMFYDFDIFAKWVKDVRAAGINCPIIPGVMPIQTYGGFQRATARFG 246
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
T +P AL+P++D+++ V+ G L EMCKKI+ G LH+YT+NLEK + +
Sbjct: 247 TLVPQYFHDALDPVRDDDQKVREIGTRLVGEMCKKIVGTGLGISGLHIYTMNLEKGSRML 306
Query: 299 LKNLGL 304
L LGL
Sbjct: 307 LDYLGL 312
>H0GUP5_9SACH (tr|H0GUP5) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae x Saccharomyces kudriavzevii VIN7
GN=VIN7_7061 PE=3 SV=1
Length = 540
Score = 301 bits (772), Expect = 1e-79, Method: Compositional matrix adjust.
Identities = 148/312 (47%), Positives = 205/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
D + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DADSWTPVEGGFLYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDAKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + ++ R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFISWCSEVRAAGMAVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP ++ LEPIKD++E V+ G +L +MC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQAFLSQLEPIKDDDELVRDIGTNLIVQMCQKLLNSGYISHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>C1GYS1_PARBA (tr|C1GYS1) Methylenetetrahydrofolate reductase OS=Paracoccidioides
brasiliensis (strain ATCC MYA-826 / Pb01) GN=PAAG_03665
PE=3 SV=1
Length = 629
Score = 301 bits (772), Expect = 2e-79, Method: Compositional matrix adjust.
Identities = 146/301 (48%), Positives = 196/301 (65%), Gaps = 9/301 (2%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG +++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+D AL++ G N+LALRGDPP ++K+ EGGF A+DLVK+I
Sbjct: 79 CMHLTCTDMPREKVDAALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDLVKYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G +D + + +LK KVDAG IITQ+FYD
Sbjct: 139 RVKYGNHFDIGVAGYPE---------GCEDQDDPELLMQHLKEKVDAGGTFIITQMFYDV 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + +CR+ GI PI+PGIMPI+ Y FIR + + K +IP + ALEP+K+++ A
Sbjct: 190 DNFLAWVKNCREKGIKVPIIPGIMPIHTYAAFIRRSNWTKIQIPPGWLEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPANAIQ 320
V+ G L MCKK+LA G LH YT+NL+++ +L LGLI P +P Q
Sbjct: 250 VRNLGKSLVANMCKKMLASGIHHLHFYTMNLQQATKMVLDELGLIPSHETPLQKPLPWRQ 309
Query: 321 A 321
+
Sbjct: 310 S 310
>F0XZS1_AURAN (tr|F0XZS1) Methylenetetrahydrofolate reductase OS=Aureococcus
anophagefferens GN=AURANDRAFT_20828 PE=3 SV=1
Length = 338
Score = 301 bits (771), Expect = 2e-79, Method: Compositional matrix adjust.
Identities = 146/299 (48%), Positives = 202/299 (67%), Gaps = 5/299 (1%)
Query: 2 KVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRM-VAHSPSFCDITWGAGGS 60
K+ + I + AA + V S+E+FPP++E GV NL R +RM A P FCD+TWGAGGS
Sbjct: 3 KINDLIAQKAAKGEDWV--SYEYFPPRSEQGVKNLEARFERMKAARMPLFCDMTWGAGGS 60
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T+++ KM+ +G+E MHLTCTN+ + AL+T + NG+ N++ALRGDPP GQ
Sbjct: 61 TSDLTMELTLKMKQ-LGLEPNMHLTCTNVAKADVVKALKTCRDNGVANIVALRGDPPVGQ 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPE-DYQNDLT 179
DK+ EGGF CA DLVK IR HGDYF +++AGYPE HPD I P+ ++ ++
Sbjct: 120 DKWEATEGGFECALDLVKFIRETHGDYFCLSVAGYPEGHPDTIVHKVFVCPDASFKLEMD 179
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGAD+IITQ+F+D + F +CR+ GI P+VPGIM + GF +MT C
Sbjct: 180 YLKKKVDAGADMIITQMFFDASTYGAFLKECRKCGIDVPVVPGIMLVQAAGGFRKMTTMC 239
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAI 298
KT++P + A++ ++ +K+YG+ LG EM ++L +G LH YTLNLEKS LAI
Sbjct: 240 KTRVPEAVAKAVDTRASDDAELKSYGVDLGVEMSHQLLKYGAPGLHFYTLNLEKSTLAI 298
>J3Q094_PUCT1 (tr|J3Q094) Methylenetetrahydrofolate reductase OS=Puccinia
triticina (isolate 1-1 / race 1 (BBBD)) GN=PTTG_04810
PE=3 SV=1
Length = 643
Score = 301 bits (771), Expect = 2e-79, Method: Compositional matrix adjust.
Identities = 143/306 (46%), Positives = 199/306 (65%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ AAA N++ +SFE+FPPKT++G+ NL +R+ RM P F DITWGAGGS
Sbjct: 1 MKISQKL--AAAESENRISWSFEYFPPKTDNGLTNLYDRIYRMSQLGPIFIDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T + K G+ET MHLTCTNMP E+ID AL G +N+LALRGDPP G
Sbjct: 59 TSNLTTEFVKTAHEQFGLETCMHLTCTNMPKERIDTALREAYEFGCENILALRGDPPKGS 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ EGGF A DLV+HIRA++GD+F I +AG+PE H + + + + Y
Sbjct: 119 SEWTATEGGFEHAIDLVRHIRAQYGDHFDIAVAGFPEGH--------MHSSLSREQETIY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGA+ I TQ+FYD DIF+ + + R GIT P++PG+MPI ++ F R+T F K
Sbjct: 171 LKEKIDAGANFIFTQMFYDVDIFIDWVREIRAAGITVPVIPGLMPIQSWAQFKRVTNFSK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T +P + LEPI+ +++AV+ G L +MC+KIL G + LH YT+NLE+ I
Sbjct: 231 TIVPQYFLDKLEPIQSDDQAVREAGTKLVADMCRKILNSDLGIRILHFYTMNLERGTKMI 290
Query: 299 LKNLGL 304
L L L
Sbjct: 291 LDELNL 296
>G3Y2A7_ASPNA (tr|G3Y2A7) Methylenetetrahydrofolate reductase OS=Aspergillus
niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB
Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
GN=ASPNIDRAFT_55539 PE=3 SV=1
Length = 626
Score = 301 bits (770), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 148/317 (46%), Positives = 203/317 (64%), Gaps = 13/317 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A+ + SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAA--GRTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + +GGF A+DLVK+IR+K+G++F I + GYPE D D + + +
Sbjct: 119 EAWEAADGGFRYAKDLVKYIRSKYGNHFDIGVGGYPEGADDN---------PDVEQLIDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA +ITQ+FYDTD F+ + CR GI PI+PGIMPI Y FIR + + K
Sbjct: 170 LKEKVDAGASFVITQMFYDTDNFIGWVKKCRDRGIHVPIIPGIMPIQTYAAFIRRSDWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T+IP + + ALEP+K+++ AV+ G L +MC++++A G LH YT+NL +S +L
Sbjct: 230 TRIPPDWLEALEPVKNDDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLD 289
Query: 301 NLGLI--EETSIPRTRP 315
L L+ EET + R P
Sbjct: 290 ELNLMPSEETPLQRALP 306
>A2QCE3_ASPNC (tr|A2QCE3) Methylenetetrahydrofolate reductase OS=Aspergillus
niger (strain CBS 513.88 / FGSC A1513) GN=An02g03270
PE=3 SV=1
Length = 626
Score = 301 bits (770), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 148/317 (46%), Positives = 203/317 (64%), Gaps = 13/317 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A+ + SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAA--GRTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + +GGF A+DLVK+IR+K+G++F I + GYPE D D + + +
Sbjct: 119 EAWEAADGGFRYAKDLVKYIRSKYGNHFDIGVGGYPEGADDN---------PDVEQLIDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA +ITQ+FYDTD F+ + CR GI PI+PGIMPI Y FIR + + K
Sbjct: 170 LKEKVDAGASFVITQMFYDTDNFIGWVKKCRDRGIHVPIIPGIMPIQTYAAFIRRSDWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T+IP + + ALEP+K+++ AV+ G L +MC++++A G LH YT+NL +S +L
Sbjct: 230 TRIPPDWLEALEPVKNDDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLD 289
Query: 301 NLGLI--EETSIPRTRP 315
L L+ EET + R P
Sbjct: 290 ELNLMPSEETPLQRALP 306
>A1DH45_NEOFI (tr|A1DH45) Methylenetetrahydrofolate reductase OS=Neosartorya
fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 /
NRRL 181) GN=NFIA_086570 PE=3 SV=1
Length = 615
Score = 300 bits (769), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 143/299 (47%), Positives = 193/299 (64%), Gaps = 9/299 (3%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
+V SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG +D+T ++ Q+
Sbjct: 15 RVGISFEFFPPKTAQGVQNLYDRMDRMHSLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT+MP+EK++ AL G N+LALRGDPP ++ + EGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVNAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
VK+IR K+G++F I + GYPE D D + +LK KVDAG+ +ITQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDN---------PDVDQLIDHLKEKVDAGSSFVITQM 185
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++ CR GIT PI+PGIMPI+ Y FIR + K +IP + + ALEP+K+
Sbjct: 186 FYDIDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPDWLEALEPVKN 245
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
++ AVK G L +MC+++LA G K LH YT+NL ++ A+L+ L LI P RP
Sbjct: 246 DDAAVKEIGKRLVADMCRRLLAAGIKHLHFYTMNLAQATQAVLEELKLIPSEETPLQRP 304
>Q2UEQ8_ASPOR (tr|Q2UEQ8) Methylenetetrahydrofolate reductase OS=Aspergillus
oryzae (strain ATCC 42149 / RIB 40) GN=AO090026000520
PE=3 SV=1
Length = 612
Score = 300 bits (769), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 147/315 (46%), Positives = 199/315 (63%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A++ +V SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAAE--RVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ +G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPTEKVDAALQAAYKSGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGG A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EKWEAAEGGLRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA +ITQ+FYDTD+F+ + CR GI PI+PGIMPI Y FIR + K
Sbjct: 170 LKEKVDAGASFVITQMFYDTDLFISWVKKCRAKGINVPIIPGIMPIQTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IP + + LEP+K+++ AVK G L +MC+++LA G LH YT+NL ++ +L
Sbjct: 230 IHIPEDWLETLEPVKNDDAAVKEIGKVLIADMCRRLLAAGINHLHFYTMNLAQATQLVLD 289
Query: 301 NLGLIEETSIPRTRP 315
L L+ P RP
Sbjct: 290 ELKLLPSEETPIQRP 304
>I8TUJ4_ASPO3 (tr|I8TUJ4) Methylenetetrahydrofolate reductase OS=Aspergillus
oryzae (strain 3.042) GN=Ao3042_05682 PE=3 SV=1
Length = 612
Score = 300 bits (769), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 147/315 (46%), Positives = 199/315 (63%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A++ +V SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAAE--RVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ +G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPTEKVDAALQAAYKSGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGG A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EKWEAAEGGLRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA +ITQ+FYDTD+F+ + CR GI PI+PGIMPI Y FIR + K
Sbjct: 170 LKEKVDAGASFVITQMFYDTDLFISWVKKCRAKGINVPIIPGIMPIQTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IP + + LEP+K+++ AVK G L +MC+++LA G LH YT+NL ++ +L
Sbjct: 230 IHIPEDWLETLEPVKNDDAAVKEIGKVLIADMCRRLLAAGINHLHFYTMNLAQATQLVLD 289
Query: 301 NLGLIEETSIPRTRP 315
L L+ P RP
Sbjct: 290 ELKLLPSEETPIQRP 304
>B8NG74_ASPFN (tr|B8NG74) Methylenetetrahydrofolate reductase OS=Aspergillus
flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 /
JCM 12722 / SRRC 167) GN=AFLA_134130 PE=3 SV=1
Length = 612
Score = 300 bits (769), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 147/315 (46%), Positives = 199/315 (63%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A++ +V SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAAE--RVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ +G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPTEKVDAALQAAYKSGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGG A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EKWEAAEGGLRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA +ITQ+FYDTD+F+ + CR GI PI+PGIMPI Y FIR + K
Sbjct: 170 LKEKVDAGASFVITQMFYDTDLFISWVKKCRAKGINVPIIPGIMPIQTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IP + + LEP+K+++ AVK G L +MC+++LA G LH YT+NL ++ +L
Sbjct: 230 IHIPEDWLETLEPVKNDDAAVKEIGKVLIADMCRRLLAAGINHLHFYTMNLAQATQLVLD 289
Query: 301 NLGLIEETSIPRTRP 315
L L+ P RP
Sbjct: 290 ELKLLPSEETPIQRP 304
>G0WG35_NAUDC (tr|G0WG35) Methylenetetrahydrofolate reductase OS=Naumovozyma
dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 /
NBRC 0211 / NRRL Y-12639) GN=NDAI0I01770 PE=3 SV=1
Length = 598
Score = 300 bits (769), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 154/335 (45%), Positives = 209/335 (62%), Gaps = 22/335 (6%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MKV EK+ EA+ +K FSFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKVTEKL-EASHKSSSKTTFSFEYFVPKTSQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+E+ID AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSQLSTDLISTAQSVLGLETCMHLTCTNMPIEEIDSALKKAYDSGCQNILALRGDPPI 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+K+ EGGF A+DL+K+IR K+GDYF I +AGYPE HP+ +D + +
Sbjct: 120 NSNKWEACEGGFNYAKDLIKYIRLKYGDYFDIGVAGYPEGHPEE---------KDIELNF 170
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG + IITQ+FYD D F+ + + R GI PI+PGIMPI Y F+R +
Sbjct: 171 KYLKEKIDAGGNFIITQMFYDVDNFIDWCDKVRAYGIDVPIIPGIMPITTYGAFLRRAQW 230
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALA 297
+ IP + + L+PIKD++E V+ G L MC+K++ G K LH+YT+NLEK+ L
Sbjct: 231 GEINIPQDFLDKLDPIKDDDELVREMGTELIVGMCQKLIDSGHVKHLHIYTMNLEKAPLM 290
Query: 298 ILKNLGLI---------EETSIPRTRPANAIQAKE 323
IL LGL+ +E +P + N + E
Sbjct: 291 ILDKLGLLPTEGEYNGAQEAMLPWRKSLNPKRKNE 325
>Q5B0P7_EMENI (tr|Q5B0P7) Methylenetetrahydrofolate reductase OS=Emericella
nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 /
NRRL 194 / M139) GN=AN5883.2 PE=3 SV=1
Length = 627
Score = 300 bits (769), Expect = 4e-79, Method: Compositional matrix adjust.
Identities = 151/328 (46%), Positives = 205/328 (62%), Gaps = 16/328 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A+ K+ SFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAA--GKIGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP E++D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPQERVDAALQAAYKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + +GGF A+DLVK+IR K+G++F I + GYPE D D + +
Sbjct: 119 EVWEAADGGFRYAKDLVKYIREKYGNHFCIGVGGYPEGADDN---------SDVDQLIDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ I+TQ+FYDTD F+K+ CR GI PI+PGIMPI Y FIR + K
Sbjct: 170 LKEKVDAGSSFIVTQMFYDTDNFIKWVEKCRAKGINVPIIPGIMPIQTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T IP + + ALEP+K+++ AVK G L +MC++++A G K LH YT+NL +S +L+
Sbjct: 230 THIPPDWLEALEPVKNDDAAVKQVGKRLIADMCRRLIASGIKHLHFYTMNLAQSTQLVLE 289
Query: 301 NLGL--IEETSIPR---TRPANAIQAKE 323
L L E IPR RP+ + +E
Sbjct: 290 ELELTPTAEAPIPRPLPWRPSLGLNRRE 317
>Q0GA67_EMEND (tr|Q0GA67) Methylenetetrahydrofolate reductase OS=Emericella
nidulans GN=metF PE=3 SV=1
Length = 627
Score = 300 bits (769), Expect = 4e-79, Method: Compositional matrix adjust.
Identities = 151/328 (46%), Positives = 205/328 (62%), Gaps = 16/328 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A+ K+ SFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAA--GKIGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP E++D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPQERVDAALQAAYKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + +GGF A+DLVK+IR K+G++F I + GYPE D D + +
Sbjct: 119 EVWEAADGGFRYAKDLVKYIREKYGNHFCIGVGGYPEGADDN---------SDVDQLIDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ I+TQ+FYDTD F+K+ CR GI PI+PGIMPI Y FIR + K
Sbjct: 170 LKEKVDAGSSFIVTQMFYDTDNFIKWVEKCRAKGINVPIIPGIMPIQTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T IP + + ALEP+K+++ AVK G L +MC++++A G K LH YT+NL +S +L+
Sbjct: 230 THIPPDWLEALEPVKNDDAAVKQVGKRLIADMCRRLIASGIKHLHFYTMNLAQSTQLVLE 289
Query: 301 NLGL--IEETSIPR---TRPANAIQAKE 323
L L E IPR RP+ + +E
Sbjct: 290 ELELTPTAEAPIPRPLPWRPSLGLNRRE 317
>G7X5I8_ASPKW (tr|G7X5I8) Methylenetetrahydrofolate reductase OS=Aspergillus
kawachii (strain NBRC 4308) GN=AKAW_00461 PE=3 SV=1
Length = 626
Score = 300 bits (769), Expect = 4e-79, Method: Compositional matrix adjust.
Identities = 148/317 (46%), Positives = 202/317 (63%), Gaps = 13/317 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A+ + SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHIKEKLAQNEAA--GRTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP EK+D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + +GGF A+DLVK+IR+K+G++F I + GYPE D D + +
Sbjct: 119 EAWEAADGGFRYAKDLVKYIRSKYGNHFDIGVGGYPEGADDN---------PDVDQLIDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA +ITQ+FYDTD F+ + CR GI PI+PGIMPI Y FIR + + K
Sbjct: 170 LKEKVDAGASFVITQMFYDTDNFIGWVKKCRDRGIHVPIIPGIMPIQTYAAFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T+IP + + ALEP+K+++ AV+ G L +MC++++A G LH YT+NL +S +L
Sbjct: 230 TRIPPDWLEALEPVKNDDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLD 289
Query: 301 NLGLI--EETSIPRTRP 315
L L+ EET + R P
Sbjct: 290 ELNLMPSEETPLQRALP 306
>I2FMK6_USTH4 (tr|I2FMK6) Methylenetetrahydrofolate reductase OS=Ustilago hordei
(strain Uh4875-4) GN=UHOR_06636 PE=3 SV=1
Length = 649
Score = 300 bits (767), Expect = 7e-79, Method: Compositional matrix adjust.
Identities = 145/306 (47%), Positives = 194/306 (63%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
K+ KI A A ++ +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 18 WKITNKI--AKAEKEGRIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGR 75
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D+T + K + +G+ET MHLTCTNMP EKID AL+ K G +N+LALRGDPP GQ
Sbjct: 76 TSDLTASLVKTVHTYIGLETCMHLTCTNMPREKIDRALKEAKQFGCRNILALRGDPPAGQ 135
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF A++LV++IR ++GDYF I +A +PE HP+A G +L
Sbjct: 136 SEWEPHAAGFTRAKELVEYIRQQYGDYFAIAVAAFPEGHPEAFHGPG--------KELER 187
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGAD I TQ+FYD DIF K+ + R GI CPI+PG+MPI Y GF R T
Sbjct: 188 LKEKIDAGADFIFTQMFYDFDIFAKWLKEVRAAGINCPIIPGVMPIQTYGGFQRATARFG 247
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF--KTLHLYTLNLEKSALAI 298
T +P AL+P+KD+++ V+ G L EMCKKI+ G LH+YT+NLEK + +
Sbjct: 248 TLVPQYFHDALDPVKDDDQKVRDVGTRLVGEMCKKIVGSGLGISGLHIYTMNLEKGSRML 307
Query: 299 LKNLGL 304
L LGL
Sbjct: 308 LDYLGL 313
>C1G7L7_PARBD (tr|C1G7L7) Methylenetetrahydrofolate reductase OS=Paracoccidioides
brasiliensis (strain Pb18) GN=PADG_03172 PE=3 SV=1
Length = 629
Score = 299 bits (766), Expect = 8e-79, Method: Compositional matrix adjust.
Identities = 146/301 (48%), Positives = 194/301 (64%), Gaps = 9/301 (2%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG +++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+D AL++ G N+LALRGDPP ++K+ EGGF A+DLVK+I
Sbjct: 79 CMHLTCTDMPSEKVDAALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDLVKYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G +D + + +LK KVDAG IITQ+FYD
Sbjct: 139 RDKYGNHFDIGVAGYPE---------GCEDQDDPELLMQHLKEKVDAGGTFIITQMFYDV 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CR GI PI+PGIMPI+ Y FIR + + K +IP + ALEP+K+++ A
Sbjct: 190 DNFLAWVKKCRDKGIKVPIIPGIMPIHTYAAFIRRSNWTKIQIPPGWLEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPANAIQ 320
V+ G L MCKK+LA G LH YT+NL+++ +L LGLI P +P Q
Sbjct: 250 VRNLGKSLVANMCKKMLASGIHHLHFYTMNLQQATKMVLDELGLIPSHETPLQKPLPWRQ 309
Query: 321 A 321
+
Sbjct: 310 S 310
>B0XSG0_ASPFC (tr|B0XSG0) Methylenetetrahydrofolate reductase OS=Neosartorya
fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
GN=AFUB_027060 PE=3 SV=1
Length = 615
Score = 299 bits (766), Expect = 9e-79, Method: Compositional matrix adjust.
Identities = 142/299 (47%), Positives = 192/299 (64%), Gaps = 9/299 (3%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
+V SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG +D+T ++ Q+
Sbjct: 15 RVGISFEFFPPKTAQGVQNLYDRMDRMHSLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT+MP+EK++ AL G N+LALRGDPP ++ + EGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVNAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
VK+IR K+G++F I + GYPE D D + +LK KVDAG+ +ITQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDN---------PDVDQLIDHLKEKVDAGSSFVITQM 185
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++ CR GIT PI+PGIMPI+ Y FIR + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPDWLEALEPVKN 245
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
++ AVK G L +MC+++LA G LH YT+NL ++ A+L+ L LI P RP
Sbjct: 246 DDAAVKEIGKRLVADMCRRLLAAGINHLHFYTMNLAQATQAVLEELKLIPSEETPLQRP 304
>C0RZ73_PARBP (tr|C0RZ73) Methylenetetrahydrofolate reductase OS=Paracoccidioides
brasiliensis (strain Pb03) GN=PABG_00728 PE=3 SV=1
Length = 629
Score = 299 bits (765), Expect = 9e-79, Method: Compositional matrix adjust.
Identities = 146/301 (48%), Positives = 194/301 (64%), Gaps = 9/301 (2%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG +++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+D AL++ G N+LALRGDPP ++K+ EGGF A+DLVK+I
Sbjct: 79 CMHLTCTDMPSEKVDAALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDLVKYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G +D + + +LK KVDAG IITQ+FYD
Sbjct: 139 RDKYGNHFDIGVAGYPE---------GCEDQDDPELLMQHLKEKVDAGGTFIITQMFYDV 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D FL + CR GI PI+PGIMPI+ Y FIR + + K +IP + ALEP+K+++ A
Sbjct: 190 DNFLAWVKKCRDNGIKVPIIPGIMPIHTYAAFIRRSNWTKIQIPPGWLEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPANAIQ 320
V+ G L MCKK+LA G LH YT+NL+++ +L LGLI P +P Q
Sbjct: 250 VRNLGKSLVANMCKKMLASGIHHLHFYTMNLQQATKMVLDELGLIPSHETPLQKPLPWRQ 309
Query: 321 A 321
+
Sbjct: 310 S 310
>Q0CXY7_ASPTN (tr|Q0CXY7) Methylenetetrahydrofolate reductase OS=Aspergillus
terreus (strain NIH 2624 / FGSC A1156) GN=ATEG_01447
PE=3 SV=1
Length = 619
Score = 299 bits (765), Expect = 1e-78, Method: Compositional matrix adjust.
Identities = 146/315 (46%), Positives = 200/315 (63%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A+ + SFEFFPPKT GV NL +RMDRM A PSF DITWGAGG
Sbjct: 1 MHISEKLAQNEAA--GRPGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP+EK+D AL++ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVNVAQSVYGLETCMHLTCTDMPLEKVDAALQSAYKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ +GGF A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EKWEATDGGFRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ I+TQ+FYDTD F+ + CR GI PI+PGIMPI Y F+R + K
Sbjct: 170 LKEKVDAGSSFIVTQMFYDTDNFINWVKKCRAKGINVPIIPGIMPIQTYAAFMRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP E + ALEP+K+++ AVK G L +MC+++LA G LH YT+NL +S +L+
Sbjct: 230 IRIPPEWLEALEPVKNDDAAVKEIGKGLIADMCRRLLAAGINHLHFYTMNLAQSTQLVLE 289
Query: 301 NLGLIEETSIPRTRP 315
L L P +P
Sbjct: 290 ELNLTPSEETPLQKP 304
>I1CMT8_RHIO9 (tr|I1CMT8) Methylenetetrahydrofolate reductase OS=Rhizopus delemar
(strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
43880) GN=RO3G_14479 PE=3 SV=1
Length = 562
Score = 298 bits (764), Expect = 1e-78, Method: Compositional matrix adjust.
Identities = 145/279 (51%), Positives = 185/279 (66%), Gaps = 10/279 (3%)
Query: 40 MDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALE 99
M+RM + P F DITWGAGGS+A++T +I Q+ G+ETMMHLTCTNMPVEKID ALE
Sbjct: 1 MERMQRYGPEFIDITWGAGGSSAELTTEIVATSQSVYGLETMMHLTCTNMPVEKIDKALE 60
Query: 100 TIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAH 159
K G QN+LALRGDPP GQ + E GF A DLV++IR K+GDYF I +AG+PE H
Sbjct: 61 AAKKCGCQNILALRGDPPKGQLNWESCENGFQYAIDLVRYIRQKYGDYFCIAVAGHPEGH 120
Query: 160 PDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPI 219
D D Q+DL LK KVDAGADLIITQLF+D D+F++F CR+IGI CPI
Sbjct: 121 IDN---------PDKQDDLQRLKEKVDAGADLIITQLFFDVDVFVQFVRKCREIGIQCPI 171
Query: 220 VPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH 279
+PG+ PI +Y G R+ F +P +I LE IK++++AVK YGIHL + K+I
Sbjct: 172 LPGLFPIQSYSGLSRVISFNNNHVPQKIWDDLETIKEDDQAVKDYGIHLAIQFVKQIKKE 231
Query: 280 -GFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPAN 317
G H+YT NLE+S+ IL+ LGL+ + + P N
Sbjct: 232 TGISGFHIYTFNLERSSRLILERLGLVPQLEYVKPLPWN 270
>G7IDE3_MEDTR (tr|G7IDE3) Methylenetetrahydrofolate reductase OS=Medicago
truncatula GN=MTR_1g039970 PE=1 SV=1
Length = 442
Score = 298 bits (764), Expect = 1e-78, Method: Compositional matrix adjust.
Identities = 142/170 (83%), Positives = 153/170 (90%), Gaps = 4/170 (2%)
Query: 158 AHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITC 217
AHPD IG++GLAT E YQ+DL YLKSKVDAGADLI+TQLFYDTDIFLKF NDCRQIGITC
Sbjct: 6 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 65
Query: 218 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIL 277
PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKI+
Sbjct: 66 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 125
Query: 278 AHGFKTLHLYTLNLEKSALAILKNLGLIEET----SIPRTRPANAIQAKE 323
AHG KT+HLYTLN+EKSALAIL +LGLIEE+ S+P RP N + KE
Sbjct: 126 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKE 175
>B6H6J4_PENCW (tr|B6H6J4) Methylenetetrahydrofolate reductase OS=Penicillium
chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin
54-1255) GN=Pc15g00480 PE=3 SV=1
Length = 610
Score = 298 bits (764), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 145/315 (46%), Positives = 197/315 (62%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A K SFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIREKLAKNEAE--GKTGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MPVEK+D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVSVAQSVYGLETCMHLTCTDMPVEKVDQALQAAYKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + E GF A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EAWEAAENGFCYAKDLVKYIREKYGNHFDIGVGGYPEGADDNTDVDQL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ ++TQ+FYD + F+++ CR GI PI+PGIMPI Y FIR + + K
Sbjct: 170 LKEKVDAGSSFVVTQMFYDAENFIEWVKKCRAKGINVPIIPGIMPIQTYASFIRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
K+P+E M ALEP+K+++ AV+ G L MC++++A G K LH YT+NL ++ +LK
Sbjct: 230 VKVPSEWMEALEPVKNDDSAVRDIGKTLIANMCRQLIAAGIKHLHFYTMNLAQATQLVLK 289
Query: 301 NLGLIEETSIPRTRP 315
L L P RP
Sbjct: 290 ELELTPSEDSPIQRP 304
>C8Z8C5_YEAS8 (tr|C8Z8C5) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain Lalvin EC1118 / Prise de mousse)
GN=EC1118_1G1_1585g PE=3 SV=1
Length = 600
Score = 298 bits (763), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>N1P5B8_YEASX (tr|N1P5B8) Met13p OS=Saccharomyces cerevisiae CEN.PK113-7D
GN=CENPK1137D_2850 PE=4 SV=1
Length = 600
Score = 298 bits (762), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>C7GX60_YEAS2 (tr|C7GX60) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain JAY291) GN=MET13 PE=3 SV=1
Length = 600
Score = 298 bits (762), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>A6ZU57_YEAS7 (tr|A6ZU57) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain YJM789) GN=MET13 PE=3 SV=1
Length = 600
Score = 298 bits (762), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>Q4X140_ASPFU (tr|Q4X140) Methylenetetrahydrofolate reductase OS=Neosartorya
fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 /
FGSC A1100) GN=AFUA_2G11300 PE=3 SV=1
Length = 615
Score = 298 bits (762), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 142/299 (47%), Positives = 191/299 (63%), Gaps = 9/299 (3%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
+V SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG +D+T ++ Q+
Sbjct: 15 RVGISFEFFPPKTAQGVQNLYDRMDRMHSLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT+MP+EK++ AL G N+LALRGDPP ++ + EGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVNAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
VK+IR K G++F I + GYPE D D + +LK KVDAG+ +ITQ+
Sbjct: 135 VKYIREKFGNHFDIGVGGYPEGADDN---------PDVDQLIDHLKEKVDAGSSFVITQM 185
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++ CR GIT PI+PGIMPI+ Y FIR + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPDWLEALEPVKN 245
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
++ AVK G L +MC+++LA G LH YT+NL ++ A+L+ L LI P RP
Sbjct: 246 DDAAVKEIGKRLVADMCRRLLAAGINHLHFYTMNLAQATQAVLEELKLIPSEETPLQRP 304
>E7QEM0_YEASZ (tr|E7QEM0) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain Zymaflore VL3) GN=VL3_1668 PE=3 SV=1
Length = 600
Score = 298 bits (762), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPXES 304
>E7NHJ8_YEASO (tr|E7NHJ8) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain FostersO) GN=FOSTERSO_1633 PE=3 SV=1
Length = 600
Score = 298 bits (762), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWAPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>H0GFV1_9SACH (tr|H0GFV1) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae x Saccharomyces kudriavzevii VIN7
GN=VIN7_1699 PE=3 SV=1
Length = 600
Score = 297 bits (761), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 146/308 (47%), Positives = 202/308 (65%), Gaps = 11/308 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLI 305
IL+ L ++
Sbjct: 293 ILERLNIL 300
>E7KCE7_YEASA (tr|E7KCE7) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain AWRI796) GN=AWRI796_1678 PE=3 SV=1
Length = 600
Score = 297 bits (761), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 146/308 (47%), Positives = 202/308 (65%), Gaps = 11/308 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLI 305
IL+ L ++
Sbjct: 293 ILERLNIL 300
>B3LHI5_YEAS1 (tr|B3LHI5) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain RM11-1a) GN=SCRG_01120 PE=3 SV=1
Length = 600
Score = 297 bits (761), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 146/308 (47%), Positives = 202/308 (65%), Gaps = 11/308 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLI 305
IL+ L ++
Sbjct: 293 ILERLNIL 300
>E7LU98_YEASV (tr|E7LU98) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain VIN 13) GN=VIN13_1661 PE=3 SV=1
Length = 600
Score = 297 bits (761), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 146/308 (47%), Positives = 202/308 (65%), Gaps = 11/308 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLI 305
IL+ L ++
Sbjct: 293 ILERLNIL 300
>E7Q3R8_YEASB (tr|E7Q3R8) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain FostersB) GN=FOSTERSB_1653 PE=3 SV=1
Length = 600
Score = 297 bits (761), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 147/312 (47%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWXPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>E3JWM7_PUCGT (tr|E3JWM7) Methylenetetrahydrofolate reductase OS=Puccinia
graminis f. sp. tritici (strain CRL 75-36-700-3 / race
SCCL) GN=PGTG_02893 PE=3 SV=1
Length = 644
Score = 296 bits (759), Expect = 5e-78, Method: Compositional matrix adjust.
Identities = 143/306 (46%), Positives = 198/306 (64%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ AAA N++ +SFE+FPPKT++G+ NL +R+ RM P F DITWGAGGS
Sbjct: 1 MKISQKL--AAAESENRISWSFEYFPPKTDNGLTNLYDRICRMSQLGPIFIDITWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T + K G+ET MHLTCTNMP KID AL+ G +N+LALRGDPP G
Sbjct: 59 TSNLTTEFVKTAHEQFGLETCMHLTCTNMPKSKIDTALKEAYEFGCENILALRGDPPKGS 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ EGGF A DLV+HIRA++GD+F I +AG+PE H + S + Y
Sbjct: 119 TEWTATEGGFEHAIDLVRHIRAEYGDHFDIAVAGFPEGHMHSTLSR--------EQQTIY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K++AGA+ I TQ+FYD DIF+ + + R GIT P++PG+MPI ++ F R+T F K
Sbjct: 171 LKEKIEAGANFIFTQMFYDVDIFIDWVREIRAAGITVPVIPGLMPIQSWAQFKRVTNFSK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T +P + LEPI+ +++AV+ G L +MC+KIL G + LH YT+NLE+ I
Sbjct: 231 TIVPQYFLDKLEPIQSDDQAVREAGTKLVADMCRKILNSDLGIRILHFYTMNLERGTKMI 290
Query: 299 LKNLGL 304
L L L
Sbjct: 291 LDELNL 296
>K9H2D3_PEND1 (tr|K9H2D3) Methylenetetrahydrofolate reductase OS=Penicillium
digitatum (strain Pd1 / CECT 20795) GN=PDIP_10790 PE=3
SV=1
Length = 610
Score = 296 bits (759), Expect = 6e-78, Method: Compositional matrix adjust.
Identities = 146/317 (46%), Positives = 199/317 (62%), Gaps = 13/317 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A K SFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIREKLAKNEAE--GKTGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP+EK+D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVSVAQSVYGLETCMHLTCTDMPLEKVDQALQAAYKAGCTNILALRGDPPRDK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + E GF A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 ETWEAAENGFCYAKDLVKYIRNKYGNHFDIGVGGYPEGADDNADVDQL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ ++TQ+FYD D F+++ CR GIT PI+PGIMPI Y FIR + + K
Sbjct: 170 LKEKVDAGSSFVVTQMFYDADNFIEWVKKCRAKGITVPIIPGIMPIQTYASFIRRSSWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P + M ALEP+K+++ AV+ G L MC++++A G K LH YT+NL ++ +LK
Sbjct: 230 VHVPPQWMEALEPVKNDDSAVREIGKTLIANMCRQLIAAGIKHLHFYTMNLAQATQLVLK 289
Query: 301 NLGL--IEETSIPRTRP 315
L L EE+ I R P
Sbjct: 290 ELDLSPSEESPIQRALP 306
>K9GDB8_PEND2 (tr|K9GDB8) Methylenetetrahydrofolate reductase OS=Penicillium
digitatum (strain PHI26 / CECT 20796) GN=PDIG_06110 PE=3
SV=1
Length = 610
Score = 296 bits (759), Expect = 6e-78, Method: Compositional matrix adjust.
Identities = 146/317 (46%), Positives = 199/317 (62%), Gaps = 13/317 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ + A K SFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIREKLAKNEAE--GKTGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+D+T ++ Q+ G+ET MHLTCT+MP+EK+D AL+ G N+LALRGDPP +
Sbjct: 59 LSDLTCEMVSVAQSVYGLETCMHLTCTDMPLEKVDQALQAAYKAGCTNILALRGDPPRDK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + E GF A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 ETWEAAENGFCYAKDLVKYIRNKYGNHFDIGVGGYPEGADDNADVDQL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ ++TQ+FYD D F+++ CR GIT PI+PGIMPI Y FIR + + K
Sbjct: 170 LKEKVDAGSSFVVTQMFYDADNFIEWVKKCRAKGITVPIIPGIMPIQTYASFIRRSSWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P + M ALEP+K+++ AV+ G L MC++++A G K LH YT+NL ++ +LK
Sbjct: 230 VHVPPQWMEALEPVKNDDSAVREIGKTLIANMCRQLIAAGIKHLHFYTMNLAQATQLVLK 289
Query: 301 NLGL--IEETSIPRTRP 315
L L EE+ I R P
Sbjct: 290 ELDLSPSEESPIQRALP 306
>G2WDX7_YEASK (tr|G2WDX7) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain Kyokai no. 7 / NBRC 101557)
GN=K7_MET13 PE=3 SV=1
Length = 600
Score = 296 bits (758), Expect = 8e-78, Method: Compositional matrix adjust.
Identities = 146/312 (46%), Positives = 203/312 (65%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ EK+ + + K +SFE+F PKT GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMP+ IDDALE +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
+ + VEGGF A+DL+K+I++K+GD+F I +AGYPE HP+ +D + DL
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPN-------KDVKLDL 172
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K++AG D IITQ+FYD D F+ + + R G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIEAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G+ + LH+YT+NLEK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILKNLGLIEETS 309
IL+ L ++ S
Sbjct: 293 ILERLNILPTES 304
>G0VEA4_NAUCC (tr|G0VEA4) Methylenetetrahydrofolate reductase OS=Naumovozyma
castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 /
NRRL Y-12630) GN=NCAS0D03140 PE=3 SV=1
Length = 598
Score = 296 bits (758), Expect = 8e-78, Method: Compositional matrix adjust.
Identities = 146/297 (49%), Positives = 198/297 (66%), Gaps = 13/297 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
M++ EK+ +A + +K FSFE+F PKT GV NL +RMDRM S P F D+TW AGG
Sbjct: 1 MRITEKL-QAHQRESDKPTFSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDVTWNAGG 59
Query: 60 ST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPH 118
+ ++ D+ Q+ +G+ET MHLTCTNMPV +IDDAL++ +G QN+LALRGDPP
Sbjct: 60 GRLSQLSTDLVATAQSVLGLETCMHLTCTNMPVSQIDDALKSAYDSGCQNILALRGDPPI 119
Query: 119 GQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDL 178
K+ VEGGF A+DL+K+IR+K+GD+F I +AGYPE HP+ ED +L
Sbjct: 120 NSTKWEAVEGGFNYAKDLIKYIRSKYGDHFDIGVAGYPERHPEE---------EDELLNL 170
Query: 179 TYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG + IITQ+FYD D F+++ R GI PI+PGIMPI Y F+R +
Sbjct: 171 KYLKEKIDAGGNFIITQMFYDVDNFIEWCKKVRAYGIDVPIIPGIMPITTYNAFLRRAQW 230
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKS 294
+ IP E + L+PIK+N+E V+ G L +MCKK+L G+ T LH+YT+NLEK+
Sbjct: 231 GEINIPKEFIEQLDPIKENDELVREIGTKLIVKMCKKLLQSGYVTHLHIYTMNLEKA 287
>Q6CG63_YARLI (tr|Q6CG63) Methylenetetrahydrofolate reductase OS=Yarrowia
lipolytica (strain CLIB 122 / E 150) GN=YALI0B00572g
PE=3 SV=1
Length = 583
Score = 296 bits (757), Expect = 9e-78, Method: Compositional matrix adjust.
Identities = 144/310 (46%), Positives = 203/310 (65%), Gaps = 11/310 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ K+ +A A+D + FSFEFF PKT GV NL +RMDRM P F DITW AGG
Sbjct: 1 MKISHKLEKAHAAD-STPTFSFEFFVPKTSQGVNNLYDRMDRMYQLGPQFIDITWNAGGR 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ +G+ET MHLTCT MP + +++AL++ G QN+LALRGDPP
Sbjct: 60 LSNLTNEMVATAQSALGLETCMHLTCTGMPKQLVENALQSAFDGGCQNILALRGDPPVES 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ V+GGF A+DLVK+I++K+GDYF I +A YPE P+ + L + +
Sbjct: 120 EKWEAVDGGFRYAKDLVKYIKSKYGDYFDIGVAAYPEGTPEEPDVDIL---------IDH 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG I+TQ+FYDTD FLK+ + CR GI PI+PGIMPI+ Y F+R +C+
Sbjct: 171 LKEKVDAGGTFIVTQMFYDTDNFLKWVDKCRAKGINVPIIPGIMPISTYASFMRRANWCQ 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAIL 299
+IP + + LEP+KD++ V+ G L +MC+K+L G K LH YT+NLEK+ + +L
Sbjct: 231 IQIPQDFLDQLEPVKDDDMRVRELGTQLVADMCQKMLDSGKIKHLHFYTMNLEKATVMVL 290
Query: 300 KNLGLIEETS 309
+ L L + S
Sbjct: 291 ERLNLPAQDS 300
>J7R7R4_KAZNA (tr|J7R7R4) Methylenetetrahydrofolate reductase OS=Kazachstania
naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797
/ CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082)
GN=KNAG0F02500 PE=3 SV=1
Length = 610
Score = 295 bits (756), Expect = 1e-77, Method: Compositional matrix adjust.
Identities = 152/320 (47%), Positives = 202/320 (63%), Gaps = 25/320 (7%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ +K+H + K FSFE+F PKTE GV NL +RMDRM S P F DITW AGG
Sbjct: 1 MKITDKLH-SYHELSGKPTFSFEYFVPKTEQGVQNLYDRMDRMYEASLPQFVDITWNAGG 59
Query: 60 STADV-------TLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLAL 112
+ + D+ Q+ +G+ET MHLTCTNMPV++ID+ALE+ +G QN+LAL
Sbjct: 60 GSNSTNRGITQQSTDLVATAQSVLGLETCMHLTCTNMPVQQIDNALESAFQSGCQNLLAL 119
Query: 113 RGDPPHGQ------DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSN 166
RGDPP G D++ VEGGF A DLV++IRAK+GD+F I +AGYPE HP+
Sbjct: 120 RGDPPRGPLGGGDGDEWQPVEGGFRHASDLVRYIRAKYGDHFNIGVAGYPEGHPEE---- 175
Query: 167 GLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPI 226
PE N+L YL+ KVDAGAD IITQ+FYD F+++ RQ G+ PI+PGIMPI
Sbjct: 176 --KNPE---NNLLYLREKVDAGADFIITQMFYDAGRFVEWCRQVRQAGVEVPIIPGIMPI 230
Query: 227 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLH 285
+ F+R + IP + L PIKD++E V+ G L +MC+ +L G+ LH
Sbjct: 231 TTFAAFLRRASWGSVHIPQRFLDVLTPIKDDDELVREMGTALVVQMCQTVLDSGYVNHLH 290
Query: 286 LYTLNLEKSALAILKNLGLI 305
+YT+NLEK+ L IL+ L L+
Sbjct: 291 IYTMNLEKAPLMILERLRLL 310
>F4RGV4_MELLP (tr|F4RGV4) Methylenetetrahydrofolate reductase OS=Melampsora
larici-populina (strain 98AG31 / pathotype 3-4-7)
GN=MELLADRAFT_42930 PE=3 SV=1
Length = 646
Score = 295 bits (755), Expect = 1e-77, Method: Compositional matrix adjust.
Identities = 141/306 (46%), Positives = 198/306 (64%), Gaps = 12/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ AAA +V +SFE+FPPKT++GV NL +R++RM P F DITWGAGG+
Sbjct: 1 MKISQKL--AAAEAEGRVSWSFEYFPPKTDNGVANLYDRIERMSQLGPIFIDITWGAGGT 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T + K G+ET MHLTCTNMP E+ID AL+ +G +N+LALRGDPP G
Sbjct: 59 TSNLTTEFVKTAHRQFGLETCMHLTCTNMPQEQIDSALKEAYDSGCENILALRGDPPRGS 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ EGGF A DL++HIR+ +GD+F I +AG+PE D + T Y
Sbjct: 119 SEWTATEGGFTHAVDLLRHIRSTYGDHFDIAVAGFPEGPTDPNLTRLQET--------MY 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGA I TQ+FYD D+F+ + + R GI P++PGIMPI ++ F R+T F K
Sbjct: 171 LKEKIDAGASFIFTQMFYDVDVFIDWVRELRAAGIKVPVIPGIMPIQSWAQFKRITTFHK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T +P ++ LEPI+++++AV+ G L +MC+KIL G K LH YT+NLE+ I
Sbjct: 231 TAVPPSFLSQLEPIQNDDQAVREVGTRLIADMCRKILDSDLGIKILHFYTMNLERGTKMI 290
Query: 299 LKNLGL 304
L L +
Sbjct: 291 LDELEM 296
>R9AFX7_WALIC (tr|R9AFX7) Methylenetetrahydrofolate reductase 2 OS=Wallemia
ichthyophaga EXF-994 GN=J056_004424 PE=4 SV=1
Length = 600
Score = 295 bits (754), Expect = 2e-77, Method: Compositional matrix adjust.
Identities = 145/312 (46%), Positives = 203/312 (65%), Gaps = 10/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ AA +++ +SFEFFPP+T G+ NL++R++RM P F DITW +GG
Sbjct: 1 MKITDKL--LAAEREDRLWWSFEFFPPRTAQGMTNLVDRIERMRRLGPEFIDITWHSGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
TA++T ++ K Q ++GVET MHLTCT MP EK+ +ALE K NG NVLALRGDPP GQ
Sbjct: 59 TAELTTELVKTCQASIGVETCMHLTCTGMPREKVINALEEAKKNGCTNVLALRGDPPRGQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ GF A DLVKHI++ +GDYF + +AG+PE + S+ A ++ Y
Sbjct: 119 TEWYPHPNGFTYAVDLVKHIKSVYGDYFEVAVAGFPEGNLQYKHSSDKAL------EMQY 172
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV+AGADLI+TQ+FYD D F+ + R+ GIT PIVPGIMPI + GF + +
Sbjct: 173 LKEKVEAGADLIMTQMFYDVDNFIDWCKQVRKAGITVPIVPGIMPIQTWNGFQKAVQMAQ 232
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
+P M LE +K+++ +V+ G L ++MCK+IL G + LHLYT+NLE+ I
Sbjct: 233 ANVPESWMQQLEAVKEDDASVRKVGTKLVSQMCKQILDANIGIRGLHLYTMNLERGPKMI 292
Query: 299 LKNLGLIEETSI 310
L+ L LI +T I
Sbjct: 293 LQELNLIPQTQI 304
>A4HQF9_LEIBR (tr|A4HQF9) Methylenetetrahydrofolate reductase OS=Leishmania
braziliensis GN=LBRM_35_6720 PE=3 SV=1
Length = 309
Score = 294 bits (753), Expect = 2e-77, Method: Compositional matrix adjust.
Identities = 137/301 (45%), Positives = 195/301 (64%), Gaps = 5/301 (1%)
Query: 11 AASDPNKVVFSFEFFPPKTEDGVVNLLE-RMDRMVAHSPSFCDITWGAGGSTADVTLDIA 69
AA D NK S+EF+PP++E N ++ ++ + SP F D+TWGAGG T++ T+ +
Sbjct: 10 AAEDANKWYTSYEFYPPRSEKAEENFMKVQIPNFMRQSPVFLDLTWGAGGRTSETTMRLC 69
Query: 70 KKMQNTV-GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEG 128
K +QN MH+TCTNM + I + L+ K +G++N+LALRGDPP G D+F
Sbjct: 70 KDLQNAYPDTPINMHITCTNMSHDLIKETLDFAKEHGIRNILALRGDPPRG-DEFQSNPE 128
Query: 129 GFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAG 188
GF CARDLV++I A +GDYF +++AGYPE HP I +G ED+Q +L YLK KVDAG
Sbjct: 129 GFTCARDLVRYIHATYGDYFCVSVAGYPEGHPSRIAEDGTILDEDHQKELEYLKEKVDAG 188
Query: 189 ADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIM 248
A ++ITQLFYD +++KF DCR++GIT PI+ G++PI Y GF RM CKT++P ++
Sbjct: 189 ASVVITQLFYDASLYVKFVKDCREMGITVPIIAGLLPITTYAGFTRMVSLCKTRVPGDVK 248
Query: 249 AALEPIKDNEEAVKAYGIHLGTEMCKKILAHG--FKTLHLYTLNLEKSALAILKNLGLIE 306
+E +K+N EA+K YG+ +M ++I A G + LH YTLN +LK L +
Sbjct: 249 KRVEELKENPEALKEYGVEQCVQMIERIRASGLDYHHLHFYTLNSSAQTFQVLKRLNALV 308
Query: 307 E 307
E
Sbjct: 309 E 309
>E3KZT2_PUCGT (tr|E3KZT2) Methylenetetrahydrofolate reductase OS=Puccinia
graminis f. sp. tritici (strain CRL 75-36-700-3 / race
SCCL) GN=PGTG_15769 PE=3 SV=2
Length = 593
Score = 293 bits (750), Expect = 6e-77, Method: Compositional matrix adjust.
Identities = 140/304 (46%), Positives = 194/304 (63%), Gaps = 16/304 (5%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
+++IE + E ++V F+FE+FPPKT DG+ NL R+ RM PS +TWGA GS
Sbjct: 6 VQLIESLKE------DQVYFTFEYFPPKTIDGLSNLYARIQRMANLKPSCAHVTWGASGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+D +L+IA +Q+ + + +HLTCTN+ +D L K +G+ N+LALRGDPP G
Sbjct: 60 TSDTSLEIAAMVQDQLAIPACLHLTCTNIQRTHLDQTLAQAKESGIVNILALRGDPPRGT 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ ++ + F A DLVK+IR +H D+F I +A YPE T D +L Y
Sbjct: 120 EHWIPTDHEFQHAIDLVKYIRKEHQDHFCIGVAAYPEG----------TTEFDQDQELNY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD ++TQLFYD DIFL + CR +GI PI+PGIMPI +Y GF R+T CK
Sbjct: 170 LKQKVDAGADFVVTQLFYDVDIFLNWVKACRNLGINVPIIPGIMPIQSYDGFRRLTALCK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
T IP I + L PIK +++AV+ YG+ L T+M K++ +GFK+ HL TLNLE+S ++
Sbjct: 230 TNIPESIHSKLIPIKGDDQAVRDYGVELSTQMIKRLQVNGFKSFHLCTLNLERSITRLVN 289
Query: 301 NLGL 304
LG
Sbjct: 290 QLGW 293
>K0KJW6_WICCF (tr|K0KJW6) Methylenetetrahydrofolate reductase OS=Wickerhamomyces
ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM
3599 / NBRC 0793 / NRRL Y-1031) GN=BN7_949 PE=3 SV=1
Length = 603
Score = 292 bits (747), Expect = 1e-76, Method: Compositional matrix adjust.
Identities = 144/306 (47%), Positives = 199/306 (65%), Gaps = 11/306 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M++ K+ E + + + FSFEFF PKT GV NL +RMDRM +P F D+TW AGG
Sbjct: 1 MRISHKL-EQSHKENDIPTFSFEFFVPKTSQGVQNLYDRMDRMYNVNPQFIDVTWNAGGR 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T DI + Q+ +G+ET MHLTCTNMPV+ ID AL+ +G QN+LALRGDPP
Sbjct: 60 LSNLTTDIVQTAQSVLGLETCMHLTCTNMPVDLIDKALKEAYDSGCQNILALRGDPPVEG 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
++ VEGGF A+DLVK+IR K+G++F I +A YPE HP+ + L + +
Sbjct: 120 GEWTAVEGGFQHAKDLVKYIRNKYGNHFDIGVAAYPEGHPEETDIDLL---------IGF 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGAD IITQ+FYD + F+++ R I PI+PGIMPI+ Y F R + +C+
Sbjct: 171 LKEKIDAGADFIITQMFYDAENFIEWCQKLRDQDINVPIIPGIMPISTYASFKRRSTWCE 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSALAIL 299
K+P E L KD+++ V+ G L EMC K++ GF K LH YT+NLEKS++ +L
Sbjct: 231 IKVPEEFENKLLANKDDDQLVRKIGTELVAEMCSKLINSGFVKHLHFYTMNLEKSSIMVL 290
Query: 300 KNLGLI 305
+ LGLI
Sbjct: 291 EKLGLI 296
>I1CGQ8_RHIO9 (tr|I1CGQ8) Methylenetetrahydrofolate reductase OS=Rhizopus delemar
(strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
43880) GN=RO3G_12349 PE=3 SV=1
Length = 529
Score = 290 bits (743), Expect = 4e-76, Method: Compositional matrix adjust.
Identities = 145/305 (47%), Positives = 193/305 (63%), Gaps = 12/305 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+I+KI +A + + +SFE+FPPKTE G NL++R+ RM P F TWGAGGS
Sbjct: 1 MKIIDKIKQA--QEKKTINYSFEYFPPKTELGYANLIDRIGRMSQLQPEFISCTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T + TL++ Q+ G++T+MHLTCTNM +KID AL+ K+NG+QN+LALRGDPP G
Sbjct: 59 THERTLELCSTAQSVHGLDTLMHLTCTNMEKDKIDVALKEAKTNGIQNILALRGDPPRGA 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ + V+ F A DLVK+IR +G++F I +AGYPE H D + DL Y
Sbjct: 119 EYWTPVDNQFTHAIDLVKYIRQTYGNHFSIGVAGYPEGHIDCPSQ---------EQDLKY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I+TQ FYD D F + CR+IGI PIVPGIMPI Y+ F RM C
Sbjct: 170 LKEKVDAGADFIVTQFFYDVDAFKNWIKRCREIGIQVPIVPGIMPIPTYQTFRRMIHLCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAIL 299
K+P +M L+ IK +++ VK YG+ L +M K++ H+ TLNLE+S IL
Sbjct: 230 VKVPTHLMNDLDAIKGDDQKVKDYGVQLAVKMIKQLHKEANVCNFHISTLNLERSTRLIL 289
Query: 300 KNLGL 304
+ L L
Sbjct: 290 EQLEL 294
>E7RAA3_PICAD (tr|E7RAA3) Methylenetetrahydrofolate reductase OS=Pichia angusta
(strain ATCC 26012 / NRRL Y-7560 / DL-1) GN=HPODL_3526
PE=3 SV=1
Length = 598
Score = 290 bits (741), Expect = 7e-76, Method: Compositional matrix adjust.
Identities = 147/329 (44%), Positives = 200/329 (60%), Gaps = 18/329 (5%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MKV K+ E+ + FSFEFF PKT G+ NL +RMDRM +P F DITW AGG
Sbjct: 1 MKVTNKLLESHKEENAPATFSFEFFTPKTSQGLQNLYDRMDRMYDLNPLFIDITWNAGGR 60
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ + +G+ET MHLTCTNM + ID AL + +G QN+LALRGDPP
Sbjct: 61 LSTLTTEMVQTTSTVLGLETCMHLTCTNMKTDLIDQALRSAYESGCQNILALRGDPPLDG 120
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ G F A+DL+++IR +GD+F I +A YPE HP+ D L Y
Sbjct: 121 S---ESTGDFKYAKDLIRYIRKHYGDHFCIGVAAYPEGHPEE---------SDPVKTLKY 168
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAGAD I+TQ+FYDT+ F+ + ++CR+IGIT PI+PGIMPI+ Y FIR G+ +
Sbjct: 169 LKEKQDAGADFIVTQMFYDTENFINWCDECRKIGITMPIIPGIMPISTYAAFIRRAGWSE 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIL-AHGFKTLHLYTLNLEKSALAIL 299
IP ALEPIKD++ V+ G L EMC+++L + LH YT+NLEKS L IL
Sbjct: 229 IAIPKHFSEALEPIKDDDAKVREVGTKLVIEMCQQLLESKRVNHLHFYTMNLEKSTLMIL 288
Query: 300 KNLGLIEETSI-----PRTRPANAIQAKE 323
+ L L+ + + P + N ++KE
Sbjct: 289 QGLNLVTKQQLHDMKQPWRKSLNPNRSKE 317
>F9FK60_FUSOF (tr|F9FK60) Methylenetetrahydrofolate reductase OS=Fusarium
oxysporum (strain Fo5176) GN=FOXB_06789 PE=3 SV=1
Length = 621
Score = 289 bits (740), Expect = 7e-76, Method: Compositional matrix adjust.
Identities = 140/283 (49%), Positives = 183/283 (64%), Gaps = 9/283 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M VEK++DAL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWTAADGGFQYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +G++F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRDTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 189 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
AV+ G L MC+K+LA+G LH YT+NL ++ +L+ L
Sbjct: 249 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEEL 291
>E9ED23_METAQ (tr|E9ED23) Methylenetetrahydrofolate reductase OS=Metarhizium
acridum (strain CQMa 102) GN=MAC_07771 PE=3 SV=1
Length = 624
Score = 289 bits (740), Expect = 9e-76, Method: Compositional matrix adjust.
Identities = 140/293 (47%), Positives = 189/293 (64%), Gaps = 9/293 (3%)
Query: 10 AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIA 69
A A + FSFE+FPPKT GV NL +R+DRM P F DITWGAGG A++T ++
Sbjct: 37 AEAEKGGQPSFSFEYFPPKTAQGVQNLYDRIDRMYNFGPKFIDITWGAGGRIAELTCEMV 96
Query: 70 KKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGG 129
+ Q+ G+ET MHLTCT+M +EK++DAL+ G N+LALRGDPP Q+K+ EGG
Sbjct: 97 LQAQSVYGLETCMHLTCTDMGLEKVNDALKKAYKAGCTNILALRGDPPRAQEKWTATEGG 156
Query: 130 FACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGA 189
F ARDLVKHIRA +GD+F I +AGYPE D +D + L +LK KVD GA
Sbjct: 157 FHYARDLVKHIRATYGDHFDIGVAGYPEGCDDN---------KDEEQLLDHLKEKVDMGA 207
Query: 190 DLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMA 249
I+TQ+FYD D F+++ R+ GI PI+PGIMPI Y F+R + K+P M
Sbjct: 208 SFIVTQMFYDADNFVRWVGKVRERGINIPILPGIMPIATYASFLRRAKHMQCKVPDHWMT 267
Query: 250 ALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
ALEP+K+++ AV+ G L +MC+K+LA+G LH YT+NL ++ +L+ L
Sbjct: 268 ALEPVKNDDVAVREIGKTLVADMCRKLLANGIYHLHFYTMNLAQATRMVLEEL 320
>J9MTN4_FUSO4 (tr|J9MTN4) Methylenetetrahydrofolate reductase OS=Fusarium
oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 /
FGSC 9935 / NRRL 34936) GN=FOXG_06273 PE=3 SV=1
Length = 616
Score = 289 bits (740), Expect = 9e-76, Method: Compositional matrix adjust.
Identities = 140/283 (49%), Positives = 183/283 (64%), Gaps = 9/283 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q G+E
Sbjct: 13 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 72
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M VEK++DAL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 73 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWTAADGGFQYARDLVKH 132
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +G++F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 133 IRDTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGASFIVTQMFYD 183
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 184 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 243
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
AV+ G L MC+K+LA+G LH YT+NL ++ +L+ L
Sbjct: 244 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEEL 286
>K5X1L7_AGABU (tr|K5X1L7) Methylenetetrahydrofolate reductase OS=Agaricus
bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627
/ FGSC 10392) GN=AGABI1DRAFT_111963 PE=3 SV=1
Length = 600
Score = 289 bits (739), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 150/307 (48%), Positives = 208/307 (67%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +KI + S NK+ +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MKISQKIQQQ--SKENKLWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T + K Q+ +G+ET MHLTCTNMP+EK+D AL K++G +NVLALRGDPP G+
Sbjct: 59 TSELTSQMVKTCQSLIGIETCMHLTCTNMPIEKVDIALREAKASGCRNVLALRGDPPAGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+++ +EGGF DLV+HIR +GDYF I IAG+P+ L PE+ + ++ +
Sbjct: 119 EEWEAIEGGFVHGIDLVRHIRKLYGDYFDIAIAGFPQQM--------LLPPEELEQEMMW 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG I TQ+FYD +IF+K+ + R+ GIT PI+PGI PI + GF+R T K
Sbjct: 171 LKEKIDAGCSFIFTQMFYDVEIFIKWVHCVREHGITIPIIPGIAPIQTWNGFMRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T IP M LEPIK+N+E V+ GI L +MC++ILA G + LH YT+NLEK +
Sbjct: 231 TIIPQSFMDVLEPIKNNDEQVRKLGIKLVADMCRRILAEPLGIQGLHFYTMNLEKGTKML 290
Query: 299 LKNLGLI 305
L+ L L+
Sbjct: 291 LEELNLV 297
>K9I4E4_AGABB (tr|K9I4E4) Methylenetetrahydrofolate reductase OS=Agaricus
bisporus var. bisporus (strain H97 / ATCC MYA-4626 /
FGSC 10389) GN=AGABI2DRAFT_193205 PE=3 SV=1
Length = 600
Score = 289 bits (739), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 150/307 (48%), Positives = 208/307 (67%), Gaps = 12/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +KI + S NK+ +SFE+FPP+T G+ NLL+R++RM A P F DITW AGG
Sbjct: 1 MKISQKIQQQ--SKENKLWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T+++T + K Q+ +G+ET MHLTCTNMP+EK+D AL K++G +NVLALRGDPP G+
Sbjct: 59 TSELTSQMVKTCQSLIGIETCMHLTCTNMPIEKVDIALREAKASGCRNVLALRGDPPAGK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+++ +EGGF DLV+HIR +GDYF I IAG+P+ L PE+ + ++ +
Sbjct: 119 EEWEAIEGGFVHGIDLVRHIRKLYGDYFDIAIAGFPQQM--------LLPPEELEQEMIW 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG I TQ+FYD +IF+K+ + R+ GIT PI+PGI PI + GF+R T K
Sbjct: 171 LKEKIDAGCSFIFTQMFYDVEIFIKWVHCVREHGITIPIIPGIAPIQTWNGFMRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T IP M LEPIK+N+E V+ GI L +MC++ILA G + LH YT+NLEK +
Sbjct: 231 TIIPQSFMDVLEPIKNNDEQVRKLGIKLVADMCRRILAEPLGIQGLHFYTMNLEKGTKML 290
Query: 299 LKNLGLI 305
L+ L L+
Sbjct: 291 LEELNLV 297
>G1X9G2_ARTOA (tr|G1X9G2) Methylenetetrahydrofolate reductase OS=Arthrobotrys
oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)
GN=AOL_s00076g269 PE=3 SV=1
Length = 623
Score = 288 bits (738), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 145/305 (47%), Positives = 191/305 (62%), Gaps = 11/305 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +KI AA K FSFE++ PKT GV NL +RM+RM + P F DITW AGG
Sbjct: 1 MHIKDKI--AACEKAGKPCFSFEYYVPKTAQGVQNLYDRMERMGSFGPQFIDITWNAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q G+ET MHLTCT M EK+D+AL+ + G N+LALRGDPP
Sbjct: 59 LSNLTTEMVNVAQTVYGLETCMHLTCTGMEKEKVDNALQEAYNGGCTNILALRGDPPREN 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ V GGF A+DLVKHIR K+GDYF I +AGYPE D + + L L +
Sbjct: 119 EKWSAVPGGFRYAKDLVKHIREKYGDYFDIGVAGYPEGCDDEVDPDIL---------LDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG IITQ+FYD DIFL + N R GIT PI+PGIMPI+ Y FIR + K
Sbjct: 170 LKEKIDAGGTFIITQMFYDVDIFLDWVNKVRAKGITVPIIPGIMPIHTYAAFIRRATWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P + + LEP+K+++ AV+ G L E+CKKILA G LH YT+NL + +L+
Sbjct: 230 IHVPEKWLEVLEPVKNDDVAVRDIGRDLVVELCKKILAAGINQLHFYTMNLATATRMVLE 289
Query: 301 NLGLI 305
L L+
Sbjct: 290 GLELM 294
>K1VJG4_TRIAC (tr|K1VJG4) Methylenetetrahydrofolate reductase OS=Trichosporon
asahii var. asahii (strain CBS 8904) GN=A1Q2_04779 PE=3
SV=1
Length = 594
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 143/307 (46%), Positives = 191/307 (62%), Gaps = 10/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ A A + +SFE+FPP+T G+ NL +R++RM P F DITWGAGG
Sbjct: 1 MKITDKL--AKAEREGRPFWSFEYFPPRTAQGLQNLYDRIERMRNLGPEFIDITWGAGGK 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
AD+T + + Q T+G+ET MHLTCT MP EK++ AL K G QN+LALRGDPP G
Sbjct: 59 NADLTSSLVQVCQETIGIETCMHLTCTEMPKEKVEWALAQAKQFGCQNILALRGDPPAGS 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ GGF A DLVK+I ++ F + +AG+P+ HP+ TPE + ++ +
Sbjct: 119 STWKPTPGGFVHAVDLVKYIHKEYPGDFCVAVAGFPDGHPETP-----PTPEGHHQEMLW 173
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I TQ+FYD DI + + R GIT PIVPGIMPI N++ F
Sbjct: 174 LKEKVDAGADFIFTQMFYDVDILFNWVKEVRSYGITVPIVPGIMPIQNWQKFQTWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALA 297
K+P AL P+K ++E V+A G L EMC+ ILA+ G K LH+YTLNLEK A
Sbjct: 234 IKVPEHWYEALNPVKGDDEQVRAVGTKLVGEMCRAILANEECGIKGLHVYTLNLEKGARM 293
Query: 298 ILKNLGL 304
+L+ LG+
Sbjct: 294 LLEELGM 300
>J6F727_TRIAS (tr|J6F727) Methylenetetrahydrofolate reductase OS=Trichosporon
asahii var. asahii (strain ATCC 90039 / CBS 2479 / JCM
2466 / KCTC 7840 / NCYC 2677 / UAMH 7654) GN=A1Q1_00789
PE=3 SV=1
Length = 594
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 143/307 (46%), Positives = 191/307 (62%), Gaps = 10/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ A A + +SFE+FPP+T G+ NL +R++RM P F DITWGAGG
Sbjct: 1 MKITDKL--AKAEREGRPFWSFEYFPPRTAQGLQNLYDRIERMRNLGPEFIDITWGAGGK 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
AD+T + + Q T+G+ET MHLTCT MP EK++ AL K G QN+LALRGDPP G
Sbjct: 59 NADLTSSLVQVCQETIGIETCMHLTCTEMPKEKVEWALAQAKQFGCQNILALRGDPPAGS 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ GGF A DLVK+I ++ F + +AG+P+ HP+ TPE + ++ +
Sbjct: 119 STWKPTPGGFVHAVDLVKYIHKEYPGDFCVAVAGFPDGHPETP-----PTPEGHHQEMLW 173
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I TQ+FYD DI + + R GIT PIVPGIMPI N++ F
Sbjct: 174 LKEKVDAGADFIFTQMFYDVDILFNWVKEVRSYGITVPIVPGIMPIQNWQKFQTWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALA 297
K+P AL P+K ++E V+A G L EMC+ ILA+ G K LH+YTLNLEK A
Sbjct: 234 IKVPEHWYEALNPVKGDDEQVRAVGTKLVGEMCRAILANEECGIKGLHVYTLNLEKGARM 293
Query: 298 ILKNLGL 304
+L+ LG+
Sbjct: 294 LLEELGM 300
>C5M851_CANTT (tr|C5M851) Methylenetetrahydrofolate reductase OS=Candida
tropicalis (strain ATCC MYA-3404 / T1) GN=CTRG_02573
PE=3 SV=1
Length = 609
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 154/336 (45%), Positives = 210/336 (62%), Gaps = 27/336 (8%)
Query: 1 MKVIEKI---HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGA 57
MK+ EK+ H+AA S P FSFEFF PKT GV NL +RMDRM +P F DITW A
Sbjct: 1 MKISEKLDQAHKAAHSPP--ATFSFEFFVPKTSQGVQNLYDRMDRMYDLNPIFIDITWNA 58
Query: 58 GGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP 117
GG ++ +T ++ Q+T+G+ET MHLTCTNM VE ID+AL+ +G QN+LALRGDPP
Sbjct: 59 GGRSSTLTNEMVYTAQSTLGLETCMHLTCTNMKVELIDEALDKAYKSGCQNILALRGDPP 118
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
+ G F A+DL+ +I K+ ++F I +AGYPE HP+ ++ L T
Sbjct: 119 LDGS---ESTGDFKYAKDLIAYIHKKYENHFNIGVAGYPEGHPEE--TDELKT------- 166
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
L YLK K DAGA+ IITQ+FYD D F+ + + R+IGI PI+PGIMPI+ Y F+R
Sbjct: 167 LEYLKEKCDAGANFIITQMFYDADNFISWCSKLRKIGIDLPIIPGIMPISTYSAFLRRAK 226
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSAL 296
+ + IP + AL+PIKD++ V+ G L +EMC+K+L G+ LH YT+NLEK+ +
Sbjct: 227 WSEIAIPQHFLDALDPIKDDDYLVREKGTELVSEMCQKLLESGYINHLHFYTMNLEKATV 286
Query: 297 AILKNLGLIEE---------TSIPRTRPANAIQAKE 323
IL+ L LIE T +P + N ++KE
Sbjct: 287 MILEKLNLIEAVKSNEIVGVTELPWRKSLNPERSKE 322
>I1RYW1_GIBZE (tr|I1RYW1) Methylenetetrahydrofolate reductase OS=Gibberella zeae
(strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
GN=FG09572.1 PE=3 SV=1
Length = 616
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 140/283 (49%), Positives = 183/283 (64%), Gaps = 9/283 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q G+E
Sbjct: 13 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 72
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M VEK++DAL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 73 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWEAADGGFQYARDLVKH 132
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +G++F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 133 IRNTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGATFIVTQMFYD 183
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 184 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 243
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
AV+ G L MC+K+LA+G LH YT+NL ++ +L+ L
Sbjct: 244 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEEL 286
>G0T0T7_RHOG2 (tr|G0T0T7) Methylenetetrahydrofolate reductase OS=Rhodotorula
glutinis (strain ATCC 204091 / IIP 30 / MTCC 1151)
GN=RTG_02688 PE=3 SV=1
Length = 599
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 140/307 (45%), Positives = 194/307 (63%), Gaps = 13/307 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
+K+ +KI +A + +SFEFFPPKT +G VNL +R++RM P F DITWGAGGS
Sbjct: 2 VKISDKIKKAERE--GRPWWSFEFFPPKTPEGWVNLYDRIERMQQLGPIFVDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T++ T + K + +G+ET MHLTCTNMPVE +D AL+ +G +N+LALRGDPP G
Sbjct: 60 TSEATTNFVKTAHSELGLETCMHLTCTNMPVEMVDKALKATYDSGCRNILALRGDPPRGV 119
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+++ EGGF A DLVKHIR +GDYF I +AG+PE HP + E + ++ +
Sbjct: 120 EEWKPTEGGFNHAIDLVKHIRKNYGDYFCIGVAGFPEGHPQS---------ESPEAEIRH 170
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
K KVDAGAD++ TQ+FYD ++F+ + R GIT PIVPGIMPI + F R T F
Sbjct: 171 FKKKVDAGADIVFTQMFYDAEVFIDWGRRLRAAGITIPIVPGIMPIQTFAAFKRRTDFAG 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T +P E+ LEPIKD++ V+ G +MC+KIL G +H YT+NL + +
Sbjct: 231 TIVPKELWDLLEPIKDDDAKVREVGTKYVADMCRKILNADLGIHGIHCYTMNLSRGTEML 290
Query: 299 LKNLGLI 305
L+ + +
Sbjct: 291 LEEMQFV 297
>G7DSI2_MIXOS (tr|G7DSI2) Methylenetetrahydrofolate reductase OS=Mixia osmundae
(strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970)
GN=Mo00186 PE=3 SV=1
Length = 608
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 142/316 (44%), Positives = 195/316 (61%), Gaps = 13/316 (4%)
Query: 2 KVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGST 61
K+ +KI AA + + +SFE+FPP+TE G++NL +R+ RM A P F DITWGAGG+T
Sbjct: 5 KISDKIR--AAHNEGRNWWSFEYFPPRTEQGLINLYDRIGRMAALGPIFIDITWGAGGTT 62
Query: 62 ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQD 121
+D T K G+ET MHLTCTNM V ++ AL+ +G +N+LALRGDPP GQ+
Sbjct: 63 SDATTQFVKTAHEQFGLETNMHLTCTNMEVGMVERALKEAYDSGCRNILALRGDPPRGQE 122
Query: 122 KFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYL 181
++ EGGF A DL+K+IR + DYF I +AG+PE HP A ++ +L
Sbjct: 123 EWKATEGGFNHAIDLIKYIRKNYDDYFDIAVAGFPEGHPQA---------SSRAEEIEHL 173
Query: 182 KSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKT 241
K+K+DAGA +IITQ+FYD D F+ +A+D R+ GI IVPGIMPI ++ F + F KT
Sbjct: 174 KAKIDAGASIIITQMFYDIDTFINWAHDVRKAGINALIVPGIMPIQGWQSFQKCISFSKT 233
Query: 242 KIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT--LHLYTLNLEKSALAIL 299
+P LEPIKD++ AV+ G L +MC++IL F LH YT+NLEK+ +L
Sbjct: 234 IVPQHFFDVLEPIKDDDAAVREAGTKLVADMCRQILDSPFDIHGLHFYTMNLEKATSMLL 293
Query: 300 KNLGLIEETSIPRTRP 315
+ L I P
Sbjct: 294 EELNFTASVEITNPLP 309
>K3VHJ6_FUSPC (tr|K3VHJ6) Methylenetetrahydrofolate reductase OS=Fusarium
pseudograminearum (strain CS3096) GN=FPSE_05848 PE=3
SV=1
Length = 621
Score = 288 bits (737), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 140/283 (49%), Positives = 183/283 (64%), Gaps = 9/283 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M VEK++DAL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWEAADGGFQYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +G++F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRNTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 189 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
AV+ G L MC+K+LA+G LH YT+NL ++ +L+ L
Sbjct: 249 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEEL 291
>C7Z4M2_NECH7 (tr|C7Z4M2) Methylenetetrahydrofolate reductase OS=Nectria
haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596
/ MPVI) GN=NECHADRAFT_32750 PE=3 SV=1
Length = 618
Score = 288 bits (736), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 144/311 (46%), Positives = 191/311 (61%), Gaps = 11/311 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + E + +A S + FSFE+FPPKT GV NL +RMDRM P F DITWGAGG
Sbjct: 1 MHIKEMLTDAERS--GQPSFSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
A++T ++ + Q G+ET MHLTCT+M VEK++DAL G N+LALRGDPP Q
Sbjct: 59 IAELTCEMVLQAQAVYGLETCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRDQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
DK+ +GGF ARDLVKHIR+ +G++F I +AGYPE D + L L +
Sbjct: 119 DKWTAADGGFQYARDLVKHIRSTYGNHFDIGVAGYPEGCDDNKNEDEL---------LDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVD GA I+TQ+FYD D F+++ R G+ PI+PGIMPI Y F+R K
Sbjct: 170 LKEKVDMGATFIVTQMFYDADNFIRWVKKVRDRGVNVPILPGIMPIATYASFLRRANHMK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
KIP + ALEP+K+++ AV+ G L EMC+K+LA+G LH YT+NL ++ +L+
Sbjct: 230 AKIPQAWLDALEPVKNDDVAVRDIGKSLVAEMCRKLLANGIHHLHFYTMNLAQATRMVLE 289
Query: 301 NLGLIEETSIP 311
L P
Sbjct: 290 ELNWAPSAERP 300
>H6C648_EXODN (tr|H6C648) Methylenetetrahydrofolate reductase OS=Exophiala
dermatitidis (strain ATCC 34100 / CBS 525.76 /
NIH/UT8656) GN=HMPREF1120_07191 PE=3 SV=1
Length = 648
Score = 288 bits (736), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 144/312 (46%), Positives = 194/312 (62%), Gaps = 11/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A + K FSFEFFPPKT GV NL +RMDRM P+F DITWGAGG
Sbjct: 1 MHISQKL--AQAHENGKPTFSFEFFPPKTAQGVQNLYDRMDRMHDLGPAFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ Q+ G+ET MHLTCT+M ++D+AL G N+LALRGDPP Q
Sbjct: 59 HSQLTCEMVNAAQSHYGLETCMHLTCTDMERTQVDEALRLAYKAGCTNILALRGDPPRDQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ + GF A+DLV++IRA++GD+F I +AGYPE D + L + +
Sbjct: 119 EKWEAKDAGFRYAKDLVRYIRARYGDHFDIGVAGYPEGCDDHRDVDLL---------IEH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA ++TQ+FYD DIFL + CR GI PI+PGIMPI+ Y FIR + K
Sbjct: 170 LKEKVDAGATFVVTQMFYDVDIFLNWVQKCRNRGINVPILPGIMPISTYAAFIRRANWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P E ALEP+K+++ AV+ G L +MC++IL G LH YT+NL ++ IL+
Sbjct: 230 CHVPPEWYEALEPVKNDDAAVRDIGKDLVAQMCRRILDAGIHHLHFYTMNLAQATRMILE 289
Query: 301 NLGLIEETSIPR 312
L L E S R
Sbjct: 290 ELALTPEKSGRR 301
>G2WQ21_VERDV (tr|G2WQ21) Methylenetetrahydrofolate reductase OS=Verticillium
dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
GN=VDAG_00463 PE=3 SV=1
Length = 609
Score = 288 bits (736), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 140/292 (47%), Positives = 187/292 (64%), Gaps = 9/292 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q+ G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNFGPKFIDITWGAGGRIAELTCEMVTQAQSVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M ++K++DAL G N+LALRGDPP ++K+V +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNDALRKAYKAGCTNILALRGDPPREKEKWVAADGGFEYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IRA + D+F I +AGYPE G +D ++ L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPE---------GCDDNKDEESLLDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PIVPGIMPI Y F+R +P E M ALEP+K+++
Sbjct: 189 ADNFVRWVGKVRERGITIPIVPGIMPIATYASFMRRAKHMNCSVPQEFMDALEPVKNDDN 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
AV+ G L MC+KILA G LH YT+NL ++ +L+ L + + P
Sbjct: 249 AVREVGKVLVAGMCRKILAAGIHHLHFYTMNLAQATRMVLEELNWMPTSERP 300
>R7YW82_9EURO (tr|R7YW82) Methylenetetrahydrofolate reductase (NADPH)
OS=Coniosporium apollinis CBS 100218 GN=W97_05307 PE=4
SV=1
Length = 661
Score = 288 bits (736), Expect = 2e-75, Method: Compositional matrix adjust.
Identities = 144/321 (44%), Positives = 197/321 (61%), Gaps = 11/321 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ EA + K +SFEFFPPKT GV NL +RMDRM PSF D+TWGAGG
Sbjct: 1 MHISEKLAEAQKA--GKPSYSFEFFPPKTAQGVQNLYDRMDRMHGFGPSFIDVTWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ K Q+ G+ET MHLTCT+M KIDDAL + G N+LALRGDPP +
Sbjct: 59 HSQLTCEMVKTAQSAYGLETCMHLTCTDMDKSKIDDALREAYNAGCTNILALRGDPPRER 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ GGF A+DLVK+I+ K+G++F I +AGY S G ED + +
Sbjct: 119 EKWEAKAGGFRYAKDLVKYIKEKYGNHFDIGVAGY---------SEGCEDQEDADLLIDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG +ITQ+FYD DIFL + CR GIT PI+PGIMPI+ Y F+R + K
Sbjct: 170 LKEKVDAGGTFVITQMFYDVDIFLDWVKKCRAKGITVPIIPGIMPIHTYAAFLRRAHWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P E ALEP+K+++ V+ G L +MC+++L G LH YT+NL ++ +L+
Sbjct: 230 CHVPEEWTKALEPVKNDDAEVREVGKDLVAKMCRRLLDAGIIHLHFYTMNLAQATRMVLE 289
Query: 301 NLGLIEETSIPRTRPANAIQA 321
LG+ + P +P Q+
Sbjct: 290 ELGITPDLESPLDKPLPWRQS 310
>N1J4Z8_ERYGR (tr|N1J4Z8) Methylenetetrahydrofolate reductase OS=Blumeria
graminis f. sp. hordei DH14 GN=BGHDH14_bgh00637 PE=4
SV=1
Length = 625
Score = 287 bits (735), Expect = 3e-75, Method: Compositional matrix adjust.
Identities = 148/312 (47%), Positives = 195/312 (62%), Gaps = 12/312 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ +A +S FSFEFFPPKT GV NL +RMDRM PSF DITWGAGG+
Sbjct: 1 MHIKDKLRQAESS--GHPTFSFEFFPPKTTQGVQNLYDRMDRMHGLGPSFIDITWGAGGN 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
A +T+++ Q+ G+ET MHLTCT+M +EK+D AL+ G N+LALRGDPP Q
Sbjct: 59 IAQLTVEMVSVAQSQYGLETCMHLTCTDMGLEKVDKALKDAYKAGCTNILALRGDPPREQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ +GGF A+DLVKHIRA +GD+F I +AGYPE D +D + L +
Sbjct: 119 EKWTATDGGFHYAKDLVKHIRATYGDHFDIGVAGYPEGCDDQ---------DDPELLLDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV+AG I+TQ+FYD + FL++ R GI PI+PGIMPIN Y F+R
Sbjct: 170 LKEKVEAGGTFIVTQMFYDVENFLEWVGKVRAKGINVPIIPGIMPINTYASFLRRCNHMG 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSALAIL 299
KIP + ALE IK+++ AV++ G L EMC+KILA G LH YT+NL ++ +L
Sbjct: 230 CKIPPKWATALEGIKNDDAAVRSIGTGLVAEMCRKILASGLIHHLHFYTMNLAQATRMVL 289
Query: 300 KNLGLIEETSIP 311
LGL P
Sbjct: 290 DQLGLTPSEERP 301
>G8JR06_ERECY (tr|G8JR06) Methylenetetrahydrofolate reductase OS=Eremothecium
cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166
/ NRRL Y-17582) GN=Ecym_3063 PE=3 SV=1
Length = 609
Score = 287 bits (735), Expect = 4e-75, Method: Compositional matrix adjust.
Identities = 141/306 (46%), Positives = 195/306 (63%), Gaps = 13/306 (4%)
Query: 4 IEKIHEAAASDPNKV---VFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
++++ E +D N V FSFEFF PKT GV NL + MD+M P F +ITW AGG
Sbjct: 7 LQQLCEQQQTDENGVRRPSFSFEFFVPKTAQGVQNLYDLMDKMYQSQPEFINITWNAGGR 66
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ Q+ +G+ET MHLTCTNMP E ID+AL+ +G QN+LALRGDPP
Sbjct: 67 KSQLTTELVSTSQSVLGLETCMHLTCTNMPCELIDEALKQAYESGCQNILALRGDPPIVG 126
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
D + E GF A+DLV +IR K+GD+F I +AG+PE G ED Q L
Sbjct: 127 DTWAPCERGFRYAKDLVLYIREKYGDHFDIGVAGHPE---------GYEEDEDPQQVLRN 177
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA+ I+TQ+FYD D F+ + R++GI PI+PGIMPI +Y F+R +C+
Sbjct: 178 LKEKVDAGANFIVTQMFYDVDNFIDWCRKVREVGINVPIIPGIMPITSYSSFLRRAKWCQ 237
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLEKSALAIL 299
IP LEP+KDN++AV+ G + ++C+K+L G+ T LH+YT+NLE ++L IL
Sbjct: 238 IHIPQMFYEKLEPVKDNDQAVREIGTKIMADICQKLLDSGYVTHLHMYTMNLEHASLMIL 297
Query: 300 KNLGLI 305
LG++
Sbjct: 298 DRLGVL 303
>M1WGQ3_CLAPU (tr|M1WGQ3) Methylenetetrahydrofolate reductase OS=Claviceps
purpurea 20.1 GN=CPUR_05837 PE=3 SV=1
Length = 595
Score = 287 bits (734), Expect = 4e-75, Method: Compositional matrix adjust.
Identities = 137/283 (48%), Positives = 184/283 (65%), Gaps = 9/283 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL ER+DRM P F DITWGAGG A++T ++ + Q+ G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYERIDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQSVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M ++K++DAL+ G N+LALRGDPP Q+++ E GF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNDALQRAYKAGCTNILALRGDPPRAQEQWTATEDGFQYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IRA +G +F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRATYGAHFDIGVAGYPEGCDDNKDEDQL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT P++PGIMPI Y F+R + K+P MAALEP+K+++
Sbjct: 189 ADNFIRWLRKVRERGITIPVLPGIMPIATYASFLRRAKHMQCKVPEAWMAALEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
AV+ G L EMC+K+LA+G LH YT+NL ++ +L L
Sbjct: 249 AVREIGTTLVAEMCRKLLANGIYHLHFYTMNLAQATRMVLDEL 291
>E9END5_METAR (tr|E9END5) Methylenetetrahydrofolate reductase OS=Metarhizium
anisopliae (strain ARSEF 23 / ATCC MYA-3075)
GN=MAA_01221 PE=3 SV=1
Length = 595
Score = 286 bits (733), Expect = 5e-75, Method: Compositional matrix adjust.
Identities = 139/293 (47%), Positives = 188/293 (64%), Gaps = 9/293 (3%)
Query: 10 AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIA 69
A A + FSFE+FPPKT GV NL +R+DRM P F DITWGAGG A++T ++
Sbjct: 8 AEAEKGGQPSFSFEYFPPKTAQGVQNLYDRIDRMYNFGPKFIDITWGAGGRIAELTCEMV 67
Query: 70 KKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGG 129
+ Q+ G+ET MHLTCT+M ++K++ AL+ G N+LALRGDPP Q+K+ EGG
Sbjct: 68 LQAQSVYGLETCMHLTCTDMGLDKVNAALQKAYKAGCTNILALRGDPPRAQEKWTAAEGG 127
Query: 130 FACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGA 189
F ARDLVKHIRA +GD+F I +AGYPE D +D + L +LK KVD GA
Sbjct: 128 FHYARDLVKHIRATYGDHFDIGVAGYPEGCDDN---------KDEEQLLDHLKEKVDMGA 178
Query: 190 DLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMA 249
I+TQ+FYD D F+++ R+ GI PI+PGIMPI Y F+R + K+P M
Sbjct: 179 SFIVTQMFYDADNFVRWVGKVRERGINIPILPGIMPIATYASFLRRAKHMQCKVPDHWMT 238
Query: 250 ALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNL 302
ALEP+K+++ AV+ G L EMC+K+LA+G LH YT+NL ++ +L+ L
Sbjct: 239 ALEPVKNDDVAVREIGKTLVAEMCRKLLANGIYHLHFYTMNLAQATRMLLEEL 291
>E9AU75_LEIMU (tr|E9AU75) Methylenetetrahydrofolate reductase OS=Leishmania
mexicana (strain MHOM/GT/2001/U1103) GN=LMXM_36_6390
PE=3 SV=1
Length = 309
Score = 286 bits (733), Expect = 6e-75, Method: Compositional matrix adjust.
Identities = 137/301 (45%), Positives = 194/301 (64%), Gaps = 5/301 (1%)
Query: 11 AASDPNKVVFSFEFFPPKTEDGVVNLLERM-DRMVAHSPSFCDITWGAGGSTADVTLDIA 69
AA D NK S+EF+PP++E N+++ + + SP F D+TWGAGG T+D T+ +
Sbjct: 10 AAEDANKWYTSYEFYPPRSEKAEENMMKVLVPTFMRQSPVFLDVTWGAGGRTSDTTMRLC 69
Query: 70 KKMQNTV-GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEG 128
K +Q+ G MH+TCTN P I +AL+ K++G++N+LALRGDPP G++ F
Sbjct: 70 KDLQHAYPGTPINMHITCTNTPKGLIKEALDFSKTHGIRNILALRGDPPCGEE-FQADPD 128
Query: 129 GFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAG 188
GF CARDLV++I +GDYF +++AGYPE HP I +G + ED Q +L YLK KVDAG
Sbjct: 129 GFVCARDLVRYIHDTYGDYFCVSVAGYPEGHPSRIPQDGTISDEDNQKELEYLKEKVDAG 188
Query: 189 ADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIM 248
A IITQLFYD +++KF CR++GIT PI+ G++PI Y GF+RM CKT IP+++
Sbjct: 189 ASFIITQLFYDASLYVKFVKRCREMGITVPIIAGLLPITTYAGFVRMVSLCKTSIPSDVK 248
Query: 249 AALEPIKDNEEAVKAYGIHLGTEMCKKILAHG--FKTLHLYTLNLEKSALAILKNLGLIE 306
+E +K+N + +K YG+ +M ++I A G + LH YTLN ILK L +
Sbjct: 249 QRVEELKENPDGLKEYGVEQCVQMIERIRASGVDYHHLHFYTLNNSAQTFKILKQLNALV 308
Query: 307 E 307
E
Sbjct: 309 E 309
>G7E669_MIXOS (tr|G7E669) Methylenetetrahydrofolate reductase OS=Mixia osmundae
(strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970)
GN=Mo05014 PE=3 SV=1
Length = 602
Score = 285 bits (730), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 140/308 (45%), Positives = 201/308 (65%), Gaps = 14/308 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ +K+ ++ P+K ++FE+FPPKT+ G+ NL R+DRM + P++ ITWGAGGS
Sbjct: 1 MKITDKL---SSWPPDKPFYTFEYFPPKTDSGMSNLQFRLDRMASLRPAWVHITWGAGGS 57
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T + +L +A+ Q ++G++ +HLTCTNM +DD L G+ N+LALRGDPP G+
Sbjct: 58 TQERSLQLAEYAQ-SMGLDVCLHLTCTNMKKSTLDDTLLRASRVGIANILALRGDPPRGE 116
Query: 121 DKFVQVEGG-FACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ + + F A DLV++IR ++ D F I +AGYPE H D+ G Q+D+
Sbjct: 117 EYSIPDQASDFRHAIDLVRYIRREYPDQFCIGVAGYPEGHSDSEGK---------QDDVA 167
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
LK K +AGA I+TQLFYD DIFL++ + CR GIT PI+PGIMPI NY+ F RMT C
Sbjct: 168 ILKMKQEAGAHFIVTQLFYDVDIFLQWHDTCRSQGITMPILPGIMPIQNYQSFRRMTNLC 227
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
KT +P ++ LEPI++++ AVK YG++L ++ +K+ G + HL TLNLEKS IL
Sbjct: 228 KTSLPTSLLKHLEPIRNDDAAVKEYGVNLSVDIIQKLYEAGIRGFHLCTLNLEKSPRQIL 287
Query: 300 KNLGLIEE 307
LG I +
Sbjct: 288 ARLGWISD 295
>G0S5U9_CHATD (tr|G0S5U9) Methylenetetrahydrofolate reductase OS=Chaetomium
thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
GN=CTHT_0033700 PE=3 SV=1
Length = 614
Score = 285 bits (729), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 141/302 (46%), Positives = 189/302 (62%), Gaps = 9/302 (2%)
Query: 10 AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIA 69
A A + FSFE+FPPKT GV NL +RM+RM + P F DITWGAGG A++T ++
Sbjct: 8 AEAERTGEPSFSFEYFPPKTAQGVQNLYDRMERMYNYGPKFIDITWGAGGRVAELTCEMV 67
Query: 70 KKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGG 129
+ Q +G+ET MHLTCT+M VE+I+DAL G N+LALRGDPP ++K+ + G
Sbjct: 68 VQAQAYLGLETCMHLTCTDMGVERINDALRKAYKAGCTNILALRGDPPRDKEKWEAAKDG 127
Query: 130 FACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGA 189
F A+DLV HIR ++GD+F I +AGYPE D + L L +LK KVD GA
Sbjct: 128 FRYAKDLVAHIRKEYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGA 178
Query: 190 DLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMA 249
I+TQ+FYD D FL++ R+ GI+ PIVPGIMPI Y F+R K KIP E MA
Sbjct: 179 GFIVTQMFYDVDNFLRWVKKVRERGISVPIVPGIMPIATYASFLRRANHMKCKIPEEWMA 238
Query: 250 ALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETS 309
LEP+K+++ AV+ G L +MC+KIL G + LH YT+NL ++ +L+ L +
Sbjct: 239 KLEPVKNDDVAVREIGKTLVADMCRKILDAGIRHLHFYTMNLAQATRMVLEELNWLPSPD 298
Query: 310 IP 311
P
Sbjct: 299 RP 300
>R1BLH4_EMIHU (tr|R1BLH4) Putative methylenetetrahydrofolate reductase
OS=Emiliania huxleyi CCMP1516 GN=EMIHUDRAFT_437840 PE=4
SV=1
Length = 355
Score = 284 bits (726), Expect = 3e-74, Method: Compositional matrix adjust.
Identities = 150/332 (45%), Positives = 193/332 (58%), Gaps = 26/332 (7%)
Query: 2 KVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGST 61
K+I+ ++ A+ ++ SFE+FPPKT +GVV L + +D M P F D TWGAGGS+
Sbjct: 24 KIIDMVNAWTAA-TDQPFISFEYFPPKTPEGVVKLHKVIDEMCKQKPLFVDFTWGAGGSS 82
Query: 62 ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQD 121
AD+TL+++K Q V MHLTCTN E D L K G+ N++ALRGDPP GQD
Sbjct: 83 ADLTLELSKTSQQKHNVMVNMHLTCTNQSKEVCDAGLAGAKEAGICNIVALRGDPPKGQD 142
Query: 122 KFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAI------------------ 163
K+ EGGFACA DLVK++R +GDYF I +AGYPE HPD I
Sbjct: 143 KWEVTEGGFACALDLVKYMRTNYGDYFSIQVAGYPEGHPDRITKVSEMSRPLSDREKMRL 202
Query: 164 ----GSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPI 219
G + T E+Y +L YLK K DAG D+IITQLFYD ++F + D R GIT PI
Sbjct: 203 VDVDGEEFVCTDENYAIELDYLKQKCDAGGDVIITQLFYDFEVFKAWVQDLRDAGITAPI 262
Query: 220 VPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK--DNEEAVKAYGIHLGTEMCKKIL 277
PGIMP+N GF RMTGFCKT+IP + + + D + YGI T++CK+++
Sbjct: 263 FPGIMPLNACGGFKRMTGFCKTRIPPAMAKRVAELSGDDKKAEFAEYGIDYLTDLCKQLV 322
Query: 278 AHGF-KTLHLYTLNLEKSALAILKNLGLIEET 308
A LH Y LN + ILK LG T
Sbjct: 323 ASKLVPGLHFYALNQSERTFQILKRLGYYAPT 354
>K1XFY5_MARBU (tr|K1XFY5) Methylenetetrahydrofolate reductase OS=Marssonina
brunnea f. sp. multigermtubi (strain MB_m1) GN=MBM_01665
PE=3 SV=1
Length = 641
Score = 284 bits (726), Expect = 3e-74, Method: Compositional matrix adjust.
Identities = 147/311 (47%), Positives = 190/311 (61%), Gaps = 11/311 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + + + EA S + FSFEFFPPKT GV NL +RMDRM PSF DITWGAGG
Sbjct: 1 MHIKDMLSEAERS--GQTTFSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
A +T ++ Q+ G+ET MHLTCT+M E +D AL G N+LALRGDPP +
Sbjct: 59 LAQLTCEMVSVAQSQYGLETCMHLTCTDMGQEMVDAALRDAYKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+V EGGF A+DLVKHIR +G++F I +AGYPE D +D + L +
Sbjct: 119 EKWVATEGGFQYAKDLVKHIRDTYGNHFDIGVAGYPEGCDDQ---------DDPELLLEH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA I+TQ+FYD + F+++ R GIT PIVPGIMPIN Y F+R
Sbjct: 170 LKQKVDAGATFIVTQMFYDAENFIEWLGKVRAKGITVPIVPGIMPINTYASFLRRCSHMG 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+IP E AALE +K+++ AV+ G L EMC+K+LA G LH YT+NL ++ +L
Sbjct: 230 CRIPPEWSAALEVVKNDDSAVRNIGTGLVAEMCRKLLAAGIHHLHFYTMNLAQATRMLLD 289
Query: 301 NLGLIEETSIP 311
L L P
Sbjct: 290 ELKLTPSEQRP 300
>R1GCB8_9PEZI (tr|R1GCB8) Putative methylenetetrahydrofolate reductase protein
OS=Neofusicoccum parvum UCRNP2 GN=UCRNP2_9800 PE=4 SV=1
Length = 637
Score = 284 bits (726), Expect = 4e-74, Method: Compositional matrix adjust.
Identities = 142/321 (44%), Positives = 195/321 (60%), Gaps = 11/321 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ + + K FSFEFFPPKT GV NL +RMDRM P+F D+TWGAGG
Sbjct: 1 MHISQKLQDGLKN--GKPSFSFEFFPPKTAQGVQNLYDRMDRMHGLGPTFIDVTWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ K Q+ G+ET MHLTCT+M K+D+AL + G +N+LALRGDPP +
Sbjct: 59 NSTLTCEMVKVAQSVYGLETCMHLTCTDMEKTKLDEALREAYNAGCKNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ GGF A+DLVK+IR +GD+F I +AGY S G ED L +
Sbjct: 119 EKWEATAGGFRYAKDLVKYIRDTYGDHFDIGVAGY---------SEGCEDQEDPDLLLDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG I+TQ+FYD DIFL + R GI PIVPGIMPIN Y F+R + K
Sbjct: 170 LKEKVDAGGTFIVTQMFYDVDIFLDWVKKVRAKGIDVPIVPGIMPINTYAAFMRRATWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
+P + + AL+PIK+++ V+ G HL MC++++ G LH YT+NL +S +L+
Sbjct: 230 CHVPPDWLKALDPIKNDDAEVREIGKHLIATMCRRLMEAGILHLHFYTMNLAQSTRMVLE 289
Query: 301 NLGLIEETSIPRTRPANAIQA 321
LGL + P +P Q+
Sbjct: 290 ELGLTPDIQSPLEKPLPWRQS 310
>N4VAU1_COLOR (tr|N4VAU1) Methylenetetrahydrofolate reductase 1 OS=Colletotrichum
orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 /
LARS 414 / MAFF 240422) GN=Cob_10442 PE=4 SV=1
Length = 625
Score = 283 bits (725), Expect = 5e-74, Method: Compositional matrix adjust.
Identities = 139/292 (47%), Positives = 184/292 (63%), Gaps = 9/292 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q+ G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVLQAQSIYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M +EK++DAL G N+LALRGDPP +K+ + GF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALRKAYKAGCTNILALRGDPPREHEKWEATDDGFQYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IRA + D+F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPEGCDDNKDEDQL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R K+P E MAALEP+K+++
Sbjct: 189 GDNFVRWVGKVRERGITVPIIPGIMPIATYASFLRRAKHMNCKVPDEWMAALEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
AV+ G L +MC+KILA G LH YT+NL ++ +L+ L + P
Sbjct: 249 AVREIGKGLVADMCRKILAAGIHHLHFYTMNLAQATRMVLEELNWMPSNERP 300
>L7JK78_MAGOR (tr|L7JK78) Methylenetetrahydrofolate reductase OS=Magnaporthe
oryzae P131 GN=OOW_P131scaffold00244g12 PE=3 SV=1
Length = 631
Score = 283 bits (724), Expect = 6e-74, Method: Compositional matrix adjust.
Identities = 139/295 (47%), Positives = 184/295 (62%), Gaps = 9/295 (3%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
K FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q
Sbjct: 15 KPSFSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVTQAQTYF 74
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT+M VEK++DAL G N+LALRGDPP ++K+ + GF A+DL
Sbjct: 75 GLETCMHLTCTDMGVEKVNDALSKAYKAGCTNILALRGDPPRDKEKWEAAQDGFNYAKDL 134
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
V HIR +GD+F I +AGYPE D + L L +LK KVD GA I+TQ+
Sbjct: 135 VSHIRKTYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQM 185
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++ R+ GIT PI+PGIMPI Y F+R + +IP E + LEPIK
Sbjct: 186 FYDADNFVRWVGRVRERGITVPIIPGIMPIATYASFLRRANHMQARIPEEWLQRLEPIKT 245
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
++ AV+ G L E+C+KILA G LH YT+NL +S IL++L + + P
Sbjct: 246 DDAAVRIVGRQLVVELCRKILAAGIHHLHFYTMNLAQSTALILEDLDWLPSPNKP 300
>L7IB80_MAGOR (tr|L7IB80) Methylenetetrahydrofolate reductase OS=Magnaporthe
oryzae Y34 GN=OOU_Y34scaffold00433g28 PE=3 SV=1
Length = 631
Score = 283 bits (724), Expect = 6e-74, Method: Compositional matrix adjust.
Identities = 139/295 (47%), Positives = 184/295 (62%), Gaps = 9/295 (3%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
K FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q
Sbjct: 15 KPSFSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVTQAQTYF 74
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT+M VEK++DAL G N+LALRGDPP ++K+ + GF A+DL
Sbjct: 75 GLETCMHLTCTDMGVEKVNDALSKAYKAGCTNILALRGDPPRDKEKWEAAQDGFNYAKDL 134
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
V HIR +GD+F I +AGYPE D + L L +LK KVD GA I+TQ+
Sbjct: 135 VSHIRKTYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQM 185
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++ R+ GIT PI+PGIMPI Y F+R + +IP E + LEPIK
Sbjct: 186 FYDADNFVRWVGRVRERGITVPIIPGIMPIATYASFLRRANHMQARIPEEWLQRLEPIKT 245
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
++ AV+ G L E+C+KILA G LH YT+NL +S IL++L + + P
Sbjct: 246 DDAAVRIVGRQLVVELCRKILAAGIHHLHFYTMNLAQSTALILEDLDWLPSPNKP 300
>G4MV96_MAGO7 (tr|G4MV96) Methylenetetrahydrofolate reductase OS=Magnaporthe
oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
GN=MGG_01728 PE=3 SV=1
Length = 631
Score = 283 bits (724), Expect = 6e-74, Method: Compositional matrix adjust.
Identities = 139/295 (47%), Positives = 184/295 (62%), Gaps = 9/295 (3%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
K FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q
Sbjct: 15 KPSFSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVTQAQTYF 74
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT+M VEK++DAL G N+LALRGDPP ++K+ + GF A+DL
Sbjct: 75 GLETCMHLTCTDMGVEKVNDALSKAYKAGCTNILALRGDPPRDKEKWEAAQDGFNYAKDL 134
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
V HIR +GD+F I +AGYPE D + L L +LK KVD GA I+TQ+
Sbjct: 135 VSHIRKTYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQM 185
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++ R+ GIT PI+PGIMPI Y F+R + +IP E + LEPIK
Sbjct: 186 FYDADNFVRWVGRVRERGITVPIIPGIMPIATYASFLRRANHMQARIPEEWLQRLEPIKT 245
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
++ AV+ G L E+C+KILA G LH YT+NL +S IL++L + + P
Sbjct: 246 DDAAVRIVGRQLVVELCRKILAAGIHHLHFYTMNLAQSTALILEDLDWLPSPNKP 300
>G0RA43_HYPJQ (tr|G0RA43) Methylenetetrahydrofolate reductase OS=Hypocrea
jecorina (strain QM6a) GN=TRIREDRAFT_55055 PE=3 SV=1
Length = 604
Score = 283 bits (724), Expect = 7e-74, Method: Compositional matrix adjust.
Identities = 139/303 (45%), Positives = 187/303 (61%), Gaps = 9/303 (2%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMNNFGPKFIDITWGAGGGIAELTCEMVVQAQAVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M +EK++DAL+ G N+LALRGDPP Q + +G F ARDLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALQKAYKAGCTNILALRGDPPRDQTSWKAADGNFQYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +GD+F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYPEGCDDNKDEDQL---------LDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R + +IP + MA LEP+K+++
Sbjct: 189 ADNFIRWVGRVRERGITVPILPGIMPIATYASFLRRAKHMQCRIPPDWMAKLEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPANAI 319
AV+ G L ++C+K+LA+G LH YT+NL ++ +L L P +P
Sbjct: 249 AVREIGKTLVADLCRKLLANGIHHLHFYTMNLAQATRMVLDELNWTPSPERPLKQPLPWK 308
Query: 320 QAK 322
Q+K
Sbjct: 309 QSK 311
>G2R3H5_THITE (tr|G2R3H5) Methylenetetrahydrofolate reductase OS=Thielavia
terrestris (strain ATCC 38088 / NRRL 8126)
GN=THITE_2115191 PE=3 SV=1
Length = 615
Score = 283 bits (723), Expect = 7e-74, Method: Compositional matrix adjust.
Identities = 140/302 (46%), Positives = 187/302 (61%), Gaps = 9/302 (2%)
Query: 10 AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIA 69
A A + FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++
Sbjct: 8 AEAERTGEPSFSFEYFPPKTAQGVQNLYDRMERMYNFGPKFIDITWGAGGRVAELTCEMV 67
Query: 70 KKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGG 129
+ Q +G+E MHLTCT+M E+++DAL G N+LALRGDPP ++K+ EGG
Sbjct: 68 VQAQTYLGLEACMHLTCTDMGEERVNDALRKAYKAGCTNILALRGDPPRDKEKWEATEGG 127
Query: 130 FACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGA 189
F ARDLV HIR +G++F I +AGYPE D + L L +LK KVD GA
Sbjct: 128 FRYARDLVAHIRKTYGNHFDIGVAGYPEGCDDNQDEDLL---------LDHLKEKVDMGA 178
Query: 190 DLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMA 249
I+TQ+FYD D FL++ R+ GIT PIVPGIMPI Y F+R K KIP + +A
Sbjct: 179 SFIVTQMFYDVDNFLRWVGRVRERGITVPIVPGIMPIATYASFLRRANHMKCKIPDDWLA 238
Query: 250 ALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETS 309
LEP+K+++ AV+ G L +MC+KILA G + LH YT+NL ++ +L+ L +
Sbjct: 239 KLEPVKNDDVAVRDIGKTLVADMCRKILAAGIRHLHFYTMNLAQATRMVLEELDWLPSPD 298
Query: 310 IP 311
P
Sbjct: 299 RP 300
>G9MZ58_HYPVG (tr|G9MZ58) Methylenetetrahydrofolate reductase OS=Hypocrea virens
(strain Gv29-8 / FGSC 10586) GN=TRIVIDRAFT_90038 PE=3
SV=1
Length = 597
Score = 283 bits (723), Expect = 7e-74, Method: Compositional matrix adjust.
Identities = 137/303 (45%), Positives = 190/303 (62%), Gaps = 9/303 (2%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM + P F DITWGAGG+ A++T ++ + Q G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMDSFGPKFIDITWGAGGNIAELTCEMVVQAQAVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M ++K++DAL+ G N+LALRGDPP Q+ + +G F ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNDALQKAYKAGCTNILALRGDPPRDQESWTAADGNFRYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +GD+F I +AGYPE D +D ++ L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYPEGCDDN---------KDEESLLDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R + ++P E M LEP+K+++
Sbjct: 189 ADNFIRWVGKVRERGITVPILPGIMPIATYASFLRRAKHMQCRVPPEWMTLLEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPANAI 319
AV+ G L E+C+K+LA+G LH YT+NL ++ +L L P +
Sbjct: 249 AVREIGKTLVAELCRKLLANGIHHLHFYTMNLAQATRMVLDELNWTPSPENPLKQALPWK 308
Query: 320 QAK 322
Q+K
Sbjct: 309 QSK 311
>H1VMU2_COLHI (tr|H1VMU2) Methylenetetrahydrofolate reductase OS=Colletotrichum
higginsianum (strain IMI 349063) GN=CH063_02618 PE=3
SV=1
Length = 614
Score = 282 bits (722), Expect = 1e-73, Method: Compositional matrix adjust.
Identities = 138/292 (47%), Positives = 186/292 (63%), Gaps = 9/292 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q+ G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVLQAQSIYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M +EK++DAL G N+LALRGDPP Q+K+ + GF A+DLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALRKAYKAGCTNILALRGDPPREQEKWEATDDGFRYAKDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IRA + D+F I +AGYPE G +D + L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPE---------GCDDNKDEEQLLDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GI PI+PGIMPI Y FIR K+P + MAALEPIK+++
Sbjct: 189 GDNFVRWVGKVRERGINVPIIPGIMPIATYASFIRRAKHMNCKVPDDWMAALEPIKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
AV+ G L +MC+KI+A G LH YT+NL ++ +L+ L + + P
Sbjct: 249 AVREVGKGLVADMCRKIVAAGIHHLHFYTMNLAQATRMVLEELNWMPTSDRP 300
>M5ED31_MALSM (tr|M5ED31) Genomic scaffold, msy_sf_16 OS=Malassezia sympodialis
ATCC 42132 GN=MSY001_2971 PE=4 SV=1
Length = 591
Score = 282 bits (721), Expect = 1e-73, Method: Compositional matrix adjust.
Identities = 139/306 (45%), Positives = 190/306 (62%), Gaps = 13/306 (4%)
Query: 2 KVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGST 61
K+ K+ +A A + +SFE+FPP+T G+ NLL+R++RM P F DITW AGG T
Sbjct: 8 KITAKLAKAKAE--GRTWWSFEYFPPRTPQGMSNLLDRIERMGKLGPEFVDITWNAGGRT 65
Query: 62 ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQD 121
+D+T + K +Q G+ET MHLTCTNMP KID AL K G +N+LALRGDPP
Sbjct: 66 SDLTTQLVKTVQAYFGLETCMHLTCTNMPRSKIDVALREAKDFGCRNILALRGDPPACGS 125
Query: 122 KFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYL 181
++ GFA +LV +IRA +GDYF I +AG+PE HP+A E + ++ YL
Sbjct: 126 EWEPHAAGFAHCHELVSYIRANYGDYFTIAVAGFPEGHPEAT--------EGPEKEMEYL 177
Query: 182 KSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKT 241
K K+D G+D I TQ+FYD D F+ + R GIT PIVPG+MPI NY GF R +
Sbjct: 178 KQKIDCGSDFIFTQMFYDLDTFVDWVRRVRAAGITVPIVPGVMPIQNYGGFSRAVARFRA 237
Query: 242 KIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALAI 298
+P AAL+P+K+++E V+ G L +MC+KIL H LH+YT+NLE+ + +
Sbjct: 238 HVPPHFHAALDPVKEDDEQVRLVGTRLVGDMCRKILEHPDLDIHGLHIYTMNLERGSRML 297
Query: 299 LKNLGL 304
L+ L L
Sbjct: 298 LEYLQL 303
>R4XG29_9ASCO (tr|R4XG29) Methylenetetrahydrofolate reductase OS=Taphrina
deformans PYCC 5710 GN=TAPDE_003676 PE=4 SV=1
Length = 576
Score = 282 bits (721), Expect = 1e-73, Method: Compositional matrix adjust.
Identities = 129/274 (47%), Positives = 182/274 (66%), Gaps = 10/274 (3%)
Query: 35 NLLERMDRMVAHSPS-FCDITWGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEK 93
NL +RM+RM + P F D+TWGAGG A++T D+ + Q G++T MHL CT MP EK
Sbjct: 3 NLYDRMERMASWGPPLFVDVTWGAGGRLAELTTDMVQTAQEMFGLDTCMHLICTGMPSEK 62
Query: 94 IDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIA 153
+ +AL+ +G QN+LALRGDPP Q+K+ EGGF A DLVK+IRA++GDYF I +A
Sbjct: 63 VKEALKDAYDSGCQNILALRGDPPREQEKWEATEGGFRYATDLVKYIRAEYGDYFDIGVA 122
Query: 154 GYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQI 213
GY E HP+ + D ++ +LK K+DAGA+ ++TQ+FYD DIFL + DCR+
Sbjct: 123 GYSEGHPECL---------DKSQNINHLKEKIDAGANFVVTQMFYDVDIFLSWVQDCRKA 173
Query: 214 GITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMC 273
G+ PI+PGIMPI + F+R + + IP + ALEP+K+++ AV+ G L TEMC
Sbjct: 174 GVLVPIIPGIMPITGWDSFLRRAKWSEAHIPQHFLDALEPVKNDDAAVRERGTELLTEMC 233
Query: 274 KKILAHGFKTLHLYTLNLEKSALAILKNLGLIEE 307
+ IL G LH YT+NLEK+ I++ LGL+++
Sbjct: 234 QTILDSGLHHLHFYTMNLEKATNMIIEALGLLKD 267
>B0V153_DANRE (tr|B0V153) Methylenetetrahydrofolate reductase OS=Danio rerio
GN=mthfr PE=3 SV=1
Length = 656
Score = 282 bits (721), Expect = 1e-73, Method: Compositional matrix adjust.
Identities = 150/307 (48%), Positives = 190/307 (61%), Gaps = 18/307 (5%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW---GAGGSTADVT-LDIAKKMQNT 75
FS EFFPP+T G VNL+ R DRM + P F DITW G GS + + + IA N
Sbjct: 60 FSLEFFPPRTSSGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARD 135
G+E+++HLTC N EKI D L K GL+N++ALRGDP G+D +V+ +GGF A D
Sbjct: 120 CGLESVLHLTCCNQTKEKITDHLNKAKRLGLKNIMALRGDPV-GED-WVEEDGGFNFATD 177
Query: 136 LVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQ 195
LVKHIR + DYF I +AGYP HP+A E Y++DL +LK KVDAGA I+TQ
Sbjct: 178 LVKHIRHEFDDYFDICVAGYPTGHPEA---------ESYEDDLRHLKEKVDAGAHFIVTQ 228
Query: 196 LFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKF DCR IGITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFRAETFLKFVKDCRAIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPEEIKQVIEPIK 288
Query: 256 DNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAILKNLGLIEETSIPRTR 314
DN+ A++ YGI EMCK +LA G LH YTLN E + + +L+ LGL E PR
Sbjct: 289 DNDAAIRNYGIQQAVEMCKVLLASGEVSGLHFYTLNREVATMEVLRQLGLWAED--PRRP 346
Query: 315 PANAIQA 321
AI A
Sbjct: 347 LPWAISA 353
>E3QQT1_COLGM (tr|E3QQT1) Methylenetetrahydrofolate reductase OS=Colletotrichum
graminicola (strain M1.001 / M2 / FGSC 10212)
GN=GLRG_08363 PE=3 SV=1
Length = 619
Score = 282 bits (721), Expect = 1e-73, Method: Compositional matrix adjust.
Identities = 138/292 (47%), Positives = 185/292 (63%), Gaps = 9/292 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q+ G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVLQAQSIYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M +EK++DAL G N+LALRGDPP +K+ E GF A+DLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALRKAYKAGCTNILALRGDPPREHEKWEATEDGFRYAKDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IRA + D+F I +AGYPE G +D + L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPE---------GCDDNKDEEQLLDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R+ GIT PI+PGIMPI Y F+R K+P MAALEPIK+++
Sbjct: 189 GDNFVRWVGKVRERGITVPIIPGIMPIATYSSFLRRAKHMNCKVPDAWMAALEPIKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
AV+ G L +MC+KI+A G LH YT+NL ++ +L+ L + + P
Sbjct: 249 AVREVGKGLVADMCRKIVAAGIHHLHFYTMNLAQATRMVLEELNWMPTSDRP 300
>F9XCC6_MYCGM (tr|F9XCC6) Methylenetetrahydrofolate reductase OS=Mycosphaerella
graminicola (strain CBS 115943 / IPO323)
GN=MYCGRDRAFT_109648 PE=3 SV=1
Length = 639
Score = 281 bits (720), Expect = 2e-73, Method: Compositional matrix adjust.
Identities = 138/313 (44%), Positives = 198/313 (63%), Gaps = 13/313 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ AAA + +SFE+FPPKT GV NL +RMD M P+F DITWGAGG
Sbjct: 1 MHITKKL--AAAHEKGDATYSFEYFPPKTAQGVQNLYDRMDMMHGFGPAFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ K Q+ G+ET MHLTCT+M + K+DDAL+ + G N+LALRGDPP Q
Sbjct: 59 HSSLTCEMVKVAQSAYGLETCMHLTCTDMELSKVDDALKEAYNAGCTNILALRGDPPREQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+V+ +GGF ARDL+K+I+ K+GD+F I IAGYPE G + T +++ + Y
Sbjct: 119 EKWVETQGGFRYARDLIKYIKKKYGDHFDIGIAGYPE------GPDETTTADEH---IVY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGI--TCPIVPGIMPINNYKGFIRMTGF 238
LK KVDAG ++ Q+ YD ++F+++ CR GI + PI+PGIMPI+ + FIR +
Sbjct: 170 LKEKVDAGGTFVVAQMCYDAELFIEWVQKCRDAGIPESVPIIPGIMPISTHAAFIRRANW 229
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAI 298
+ +IP ALEPIK+++ AV+ G L E C+K++A G LH YT+NL + +
Sbjct: 230 TQARIPPAWHEALEPIKNDDSAVREVGRDLIVEFCQKLMAAGIMHLHFYTMNLAAAVRMV 289
Query: 299 LKNLGLIEETSIP 311
L+ L L P
Sbjct: 290 LEKLDLTPSAESP 302
>Q2H0T7_CHAGB (tr|Q2H0T7) Methylenetetrahydrofolate reductase OS=Chaetomium
globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 /
NBRC 6347 / NRRL 1970) GN=CHGG_04609 PE=3 SV=1
Length = 616
Score = 281 bits (719), Expect = 2e-73, Method: Compositional matrix adjust.
Identities = 142/312 (45%), Positives = 192/312 (61%), Gaps = 13/312 (4%)
Query: 1 MKVIEKIHEAAAS-DPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M + E + EA + +P+ FSFE+FPPKT GV NL +RM+RM P F DITWGAGG
Sbjct: 1 MHIREMLAEAERTGNPS---FSFEYFPPKTAQGVQNLYDRMERMYNFGPKFVDITWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
A++T ++ + Q +G+E MHLTCT+M EK++DAL G N+LALRGDPP
Sbjct: 58 RIAELTCEMVVQAQTYLGLEACMHLTCTDMGEEKVNDALRKAYKAGCTNILALRGDPPRE 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
Q+K+ EGGF ARDLV HIR +G++F I +AGYPE D + L L
Sbjct: 118 QEKWEATEGGFQYARDLVGHIRKTYGNHFDIGVAGYPEGCDDNKDEDSL---------LD 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVD GA I+TQ+FYD D F+++ R+ GIT PIVPGIMPI Y F+R
Sbjct: 169 HLKEKVDMGATFIVTQMFYDADNFIRWVGRVRERGITVPIVPGIMPIATYASFLRRANHM 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
K+P E MA LE +K+++ AV+ G L +MC+KIL+ G + LH YT+NL ++ +L
Sbjct: 229 NCKVPEEWMAKLESVKNDDVAVRDIGKTLVADMCRKILSAGIRHLHFYTMNLAQATRMVL 288
Query: 300 KNLGLIEETSIP 311
+ L + P
Sbjct: 289 EELDWLPSPDRP 300
>G9P292_HYPAI (tr|G9P292) Methylenetetrahydrofolate reductase OS=Hypocrea
atroviridis (strain ATCC 20476 / IMI 206040)
GN=TRIATDRAFT_33767 PE=3 SV=1
Length = 597
Score = 281 bits (718), Expect = 3e-73, Method: Compositional matrix adjust.
Identities = 139/303 (45%), Positives = 184/303 (60%), Gaps = 9/303 (2%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RMDRM P F DITWGAGG A++T ++ + Q G+E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMNNFGPKFIDITWGAGGGIAELTCEMVVQAQAVYGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M +EK++DAL+ G N+LALRGDPP Q + +G F ARDLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALQKAYKAGCTNILALRGDPPRDQTTWTAADGNFRYARDLVKH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR +GD+F I +AGYPE D + L L +LK KVD GA I+TQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYPEGCDDNKDEDSL---------LDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL++ R+ GIT PI+PGIMPI Y F+R + ++P E M LEP+K+++
Sbjct: 189 ADNFLRWVGRVRERGITVPILPGIMPIATYASFLRRAKHMQCRVPPEWMTLLEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRPANAI 319
AV+ G L E+C+K+LA G LH YT+NL ++ +L L P +
Sbjct: 249 AVREIGKTLVAELCRKLLAGGIHHLHFYTMNLAQAVRMVLDELDWTPSAERPLKQALPWK 308
Query: 320 QAK 322
Q+K
Sbjct: 309 QSK 311
>M7SPP9_9PEZI (tr|M7SPP9) Putative methylenetetrahydrofolate reductase 1 protein
OS=Eutypa lata UCREL1 GN=UCREL1_6847 PE=4 SV=1
Length = 620
Score = 281 bits (718), Expect = 3e-73, Method: Compositional matrix adjust.
Identities = 141/310 (45%), Positives = 192/310 (61%), Gaps = 11/310 (3%)
Query: 7 IHE--AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADV 64
IH+ A A + FSFE+FPPKT GV NL +R++RM P F DITWGAGG A++
Sbjct: 3 IHDMIAEAEKSGQPSFSFEYFPPKTAQGVQNLYDRIERMYDFGPKFIDITWGAGGRIAEL 62
Query: 65 TLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFV 124
T ++ + Q G+ET MHLTCT+M EK++DAL G N+LALRGDPP ++K++
Sbjct: 63 TCEMVVQAQTYFGLETCMHLTCTDMGEEKVNDALAKAYKAGCTNILALRGDPPREKEKWI 122
Query: 125 QVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSK 184
E F ARDLV HIR K+G++FGI +AGYPE G +D L +LK K
Sbjct: 123 ATEDNFQYARDLVAHIRNKYGNHFGIGVAGYPE---------GCDDNKDEGQLLDHLKEK 173
Query: 185 VDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIP 244
VD GA I+TQ+FYD D F+++ R+ GIT PI+PGIMPI Y FIR K+P
Sbjct: 174 VDMGATFIVTQMFYDADNFVRWMGKVRERGITVPILPGIMPIATYASFIRRANHMNCKVP 233
Query: 245 AEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGL 304
M ALEPIK+++ AV+ G L ++C+KI+A G LH YT+NL ++ +L+ L
Sbjct: 234 DGWMEALEPIKNDDAAVRNVGKSLVADLCRKIMAAGIVHLHFYTMNLAQATRMVLEELDW 293
Query: 305 IEETSIPRTR 314
+ ++ PR +
Sbjct: 294 MPTSNRPRKQ 303
>B6QPH8_PENMQ (tr|B6QPH8) Methylenetetrahydrofolate reductase OS=Penicillium
marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
GN=PMAA_048540 PE=3 SV=1
Length = 607
Score = 280 bits (717), Expect = 4e-73, Method: Compositional matrix adjust.
Identities = 138/295 (46%), Positives = 189/295 (64%), Gaps = 12/295 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M V +K+ E AA+ + SFE+FPPKT GV NL +RMDRM P+F D+TWGAGGS
Sbjct: 1 MHVGQKLQEQAAT--GRPGISFEYFPPKTAQGVQNLYDRMDRMHDLGPAFIDVTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ + Q G+ET MHLTCT+MP E++D ALE + G N+LALRGDPP Q
Sbjct: 59 RSELTCEMVRIAQTVFGLETCMHLTCTDMPRERVDAALEAAYNAGCTNILALRGDPPREQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGF A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EKWEAAEGGFRYAKDLVKYIREKYGNHFDIGVGGYPEGADDNPDVDQL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ I+TQ+FYD D FL + CR GI IVPGIMPI+ Y F+R + + K
Sbjct: 170 LKEKVDAGSTFIVTQMFYDVDNFLNWVEKCRAKGINAAIVPGIMPISTYDAFMRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKS 294
+IP + + LEP+K ++ V+ G L EMC+K+LA G LH YT+NL ++
Sbjct: 230 IRIPPDWLEKLEPVKADDAKVREVGTKLVAEMCRKLLASGHIHHLHFYTMNLAQA 284
>G8ZXU8_TORDC (tr|G8ZXU8) Methylenetetrahydrofolate reductase OS=Torulaspora
delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 /
NCYC 2629 / NRRL Y-866) GN=TDEL0G03480 PE=3 SV=1
Length = 600
Score = 280 bits (716), Expect = 5e-73, Method: Compositional matrix adjust.
Identities = 158/315 (50%), Positives = 206/315 (65%), Gaps = 22/315 (6%)
Query: 1 MKVIEKI--HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGA 57
MKV EK+ H+ ++ K FS+E+F PKT GV NL +RMDRM S P F DITW A
Sbjct: 1 MKVSEKLQKHKEVST---KATFSYEYFVPKTTQGVQNLYDRMDRMYESSLPQFIDITWNA 57
Query: 58 GGST-ADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDP 116
GG + ++ D+ Q+ +G+ET MHLTCTNMPV +IDDAL+ +G QN+LALRGDP
Sbjct: 58 GGGVLSQLSTDLVATAQSVLGLETCMHLTCTNMPVSEIDDALQKAYDSGCQNILALRGDP 117
Query: 117 PHGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQN 176
P +++ VEGGF A+DLVK+I+AK+GD+F I +AGYPE H PED +
Sbjct: 118 PVDSNEWTPVEGGFRYAKDLVKYIKAKYGDHFDIGVAGYPEGH-----------PEDDTD 166
Query: 177 D---LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFI 233
D + YLK KVDAGA +ITQ+FYD DIF+ + R GI PI+PGIMPI Y F+
Sbjct: 167 DSKLIDYLKQKVDAGASFLITQMFYDADIFIAWCKKVRAAGIEIPIIPGIMPITTYAAFL 226
Query: 234 RMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKT-LHLYTLNLE 292
R +C +P E + LEPIKD+++ V+ G L EMC+KIL G+ T LHLYT+NLE
Sbjct: 227 RRAQWCDIHLPQEFLDRLEPIKDDDQQVRDTGTDLLVEMCQKILDSGYVTHLHLYTMNLE 286
Query: 293 KSALAILKNLGLIEE 307
K+ L IL LGL+ +
Sbjct: 287 KAPLMILDRLGLLSQ 301
>H9MZH5_DANRE (tr|H9MZH5) Methylenetetrahydrofolate reductase OS=Danio rerio
GN=mthfr PE=2 SV=1
Length = 656
Score = 280 bits (715), Expect = 7e-73, Method: Compositional matrix adjust.
Identities = 149/307 (48%), Positives = 189/307 (61%), Gaps = 18/307 (5%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW---GAGGSTADVT-LDIAKKMQNT 75
FS EFFPP+T G VNL+ R DRM + P F DITW G GS + + + IA N
Sbjct: 60 FSLEFFPPRTSSGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARD 135
G+E+++HLTC N EKI D L K GL+N++ALRGDP G+D +V+ +GGF A D
Sbjct: 120 CGLESVLHLTCCNQTKEKITDHLNKAKRLGLKNIMALRGDPV-GED-WVEEDGGFNFATD 177
Query: 136 LVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQ 195
LVKHIR + DYF I +AGYP HP+A E Y++DL +LK KVDAGA I+TQ
Sbjct: 178 LVKHIRHEFDDYFDICVAGYPTGHPEA---------ESYEDDLRHLKEKVDAGAHFIVTQ 228
Query: 196 LFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKF DCR IGITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFRAETFLKFVKDCRAIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPEEIKQVIEPIK 288
Query: 256 DNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAILKNLGLIEETSIPRTR 314
DN+ A++ YGI EMCK +LA G LH Y LN E + + +L+ LGL E PR
Sbjct: 289 DNDAAIRNYGIQQAVEMCKVLLASGEVSGLHFYPLNREVATMEVLRQLGLWAED--PRRP 346
Query: 315 PANAIQA 321
AI A
Sbjct: 347 LPWAISA 353
>E6R5R3_CRYGW (tr|E6R5R3) Methylenetetrahydrofolate reductase OS=Cryptococcus
gattii serotype B (strain WM276 / ATCC MYA-4071)
GN=CGB_D2260W PE=3 SV=1
Length = 617
Score = 279 bits (714), Expect = 8e-73, Method: Compositional matrix adjust.
Identities = 139/307 (45%), Positives = 190/307 (61%), Gaps = 10/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ EK+ +A + +SFEFFPP+T G+ NL +R++RM P F DITWGAGG
Sbjct: 1 MKITEKLQKAEKE--GRPFWSFEFFPPRTAQGLQNLYDRIERMRDLGPEFIDITWGAGGK 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
AD+T + + Q T+G+ET MHL CT MP EK++ AL+ KS+G QN+LALRGDP G
Sbjct: 59 NADLTNSLVQVCQATIGIETCMHLCCTEMPKEKVEWALKEAKSHGCQNILALRGDPVAGT 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ GGF A DLV++I + F + +AG+P+ HP+ G TPE ++ +
Sbjct: 119 STWEPTPGGFMNAVDLVRYIHKHYPGDFCVAVAGFPQGHPETPG-----TPEGRAQEMEW 173
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+KVDAGA+ I TQ+FYDT IF + R+ GI PIVPGIMPI N++ F +
Sbjct: 174 LKAKVDAGAEFIFTQMFYDTSIFFDWVKRVREAGINVPIVPGIMPIQNWEKFEKWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALA 297
+P+ AL P++ ++E V+ G L +MCK IL + G K LH+YTLNLEK A
Sbjct: 234 IIVPSHFYEALNPVRGDDEKVRQVGTKLVADMCKTILQNKEAGIKGLHIYTLNLEKGARM 293
Query: 298 ILKNLGL 304
+LK LG
Sbjct: 294 LLKELGF 300
>H2S3I1_TAKRU (tr|H2S3I1) Methylenetetrahydrofolate reductase OS=Takifugu
rubripes GN=LOC101078210 PE=3 SV=1
Length = 514
Score = 279 bits (714), Expect = 9e-73, Method: Compositional matrix adjust.
Identities = 149/307 (48%), Positives = 191/307 (62%), Gaps = 18/307 (5%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW---GAGGSTADVT-LDIAKKMQNT 75
FS EFFPP+T G VNL+ R DRM + P F DITW G GS + + + IA N
Sbjct: 64 FSLEFFPPRTASGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 123
Query: 76 VGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARD 135
G+E+++HLTC N +KI L K GL+N++ALRGDP G D + + EGGF A D
Sbjct: 124 CGLESILHLTCCNQTKDKITGYLGKAKHLGLKNIMALRGDPV-GAD-WEEEEGGFNYAVD 181
Query: 136 LVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQ 195
LVKHIR++ DYF I +AGYP HP+A E YQ DL +LK KVDAGAD +ITQ
Sbjct: 182 LVKHIRSEFDDYFDICVAGYPTGHPEA---------ESYQQDLRHLKEKVDAGADFVITQ 232
Query: 196 LFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKF +DCR IGITCPI+PGI PI Y+ ++ K ++P EI + LEPIK
Sbjct: 233 LFFRAETFLKFLDDCRTIGITCPILPGIFPIQGYQSLRQLVKLSKLEVPEEITSILEPIK 292
Query: 256 DNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAILKNLGLIEETSIPRTR 314
DN+ A++ YGI L EMC+ +L G LH YTLN E + + +L+ LGL E PR
Sbjct: 293 DNDAAIRNYGIQLAVEMCRVLLDSGKVPGLHFYTLNREVATMEVLRQLGLWTED--PRRP 350
Query: 315 PANAIQA 321
A+ A
Sbjct: 351 LPWAVSA 357
>Q4Q0B9_LEIMA (tr|Q4Q0B9) Methylenetetrahydrofolate reductase OS=Leishmania major
GN=LMJF_36_6390 PE=3 SV=1
Length = 309
Score = 279 bits (713), Expect = 1e-72, Method: Compositional matrix adjust.
Identities = 136/302 (45%), Positives = 194/302 (64%), Gaps = 7/302 (2%)
Query: 11 AASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAH-SPSFCDITWGAGGSTADVTLDIA 69
AA D +K S+E +PP++E ++++ + H SP F D+TWGAGG T+ T+ +
Sbjct: 10 AAEDASKWNTSYELYPPRSEKAEEDMMKVLVPNFMHQSPVFLDLTWGAGGRTSGTTMRLC 69
Query: 70 KKMQNT-VGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVE- 127
K +Q+ MH+TCTN P I + LE K++G++N+LALRGDPP G++ QV+
Sbjct: 70 KDLQHAHPDTPINMHITCTNTPKGLIKETLEFAKTHGIRNILALRGDPPSGEE--FQVDP 127
Query: 128 GGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDA 187
GFACARDLV++IR +GDYF +++AGYPE HP I NG + ED+Q +L YLK KVDA
Sbjct: 128 DGFACARDLVRYIRDTYGDYFCVSVAGYPEGHPSRIAENGTISHEDHQKELEYLKEKVDA 187
Query: 188 GADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEI 247
GA IITQLFYD +++KF CR++GIT PI+ G++PI Y GF+RM CKT +P+++
Sbjct: 188 GASFIITQLFYDASLYVKFVKRCREVGITVPILAGLLPITTYAGFVRMVSLCKTSVPSDV 247
Query: 248 MAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG--FKTLHLYTLNLEKSALAILKNLGLI 305
+E +K+N + +K YG+ +M + I A G + LH YTLN ILK L +
Sbjct: 248 KKRVEELKENPDGLKEYGVEQCVQMIECIRASGLDYHHLHFYTLNNSAQIFKILKRLNAL 307
Query: 306 EE 307
E
Sbjct: 308 VE 309
>C5K575_PERM5 (tr|C5K575) Methylenetetrahydrofolate reductase OS=Perkinsus
marinus (strain ATCC 50983 / TXsc) GN=Pmar_PMAR010241
PE=3 SV=1
Length = 583
Score = 278 bits (712), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 140/303 (46%), Positives = 192/303 (63%), Gaps = 20/303 (6%)
Query: 32 GVVNLLERMDRMVAHSPSFCDITWGAGG--STADVTLDIAKKMQNTVGVETMMHLTCTNM 89
GV NL ER+DRM P + D+TWGAGG S+++ T +I + G++ MMHLTCT+
Sbjct: 2 GVQNLYERLDRMAELGPMWIDVTWGAGGASSSSNKTFEICRNALTYHGLDVMMHLTCTHQ 61
Query: 90 PVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRAKHGDYFG 149
VE+ID+ L+ K G++N+LALRGD P ++ +GGF+ A DLV+HIR K+GDYF
Sbjct: 62 SVEEIDEVLDKCKEVGIRNILALRGDAPTQSSEWRACQGGFSHAVDLVRHIRGKYGDYFC 121
Query: 150 ITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFAND 209
I +AGYPE H +A E + DL +LK KVDAGADLIITQLFYDT++F KF
Sbjct: 122 IAVAGYPEGHLEA---------ESIEEDLVHLKEKVDAGADLIITQLFYDTEVFFKFVAA 172
Query: 210 CRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLG 269
R++GI PI PGIMPI +Y GF +MT FCKTK+P I LE +K +++ VK G+ +
Sbjct: 173 VRKLGIRVPIFPGIMPIQSYSGFKKMTEFCKTKVPRAIADQLEQVKGDDQRVKDLGVEIC 232
Query: 270 TEMCKKILAHGFK------TLHLYTLNLEKSALAILKNLGLIEE---TSIPRTRPANAIQ 320
MC +I+++G LH YTLNLE S I++ L +++ T + RP+ A
Sbjct: 233 VAMCSQIMSYGVDHTHSSGGLHFYTLNLESSVCRIIERLMMVDNHVATRVLPWRPSKASS 292
Query: 321 AKE 323
+E
Sbjct: 293 RQE 295
>A6RBU9_AJECN (tr|A6RBU9) Methylenetetrahydrofolate reductase OS=Ajellomyces
capsulata (strain NAm1 / WU24) GN=HCAG_07107 PE=3 SV=1
Length = 619
Score = 278 bits (711), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 143/315 (45%), Positives = 195/315 (61%), Gaps = 25/315 (7%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A+ + SFEFFPPKT GV NL +RMDRM + PSF DITWGAGG
Sbjct: 1 MHIKDKLAHAEAT--GRPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ Q+ G+ET MHLTCT+MP EK+D A+++ G N+LALRGDPP +
Sbjct: 59 LSELTCEMVNVAQSVYGLETCMHLTCTDMPREKVDAAIQSAFKAGCTNILALRGDPPREK 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ +EGGF A+DLVK+IR K+G++F I +AGYPE D + L + +
Sbjct: 119 EKWEAIEGGFRYAKDLVKYIRDKYGNHFDIGVAGYPEGCDDQDDPDLL---------MQH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IITQ+FYD D FL + N CR GIT PI+PGIMPI+
Sbjct: 170 LKEKVDAGGTFIITQMFYDVDNFLAWVNKCRDNGITVPIIPGIMPIHT------------ 217
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IP + + ALEP+K+++ AV+ G L MC+K+LA G LH YT+NL+++ +L
Sbjct: 218 --IPPDWLEALEPVKNDDVAVRNLGKSLVANMCRKMLAAGIHHLHFYTMNLQQATKMVLG 275
Query: 301 NLGLIEETSIPRTRP 315
L LI P +P
Sbjct: 276 ELELIPSHKTPLQKP 290
>K1QN08_CRAGI (tr|K1QN08) Methylenetetrahydrofolate reductase OS=Crassostrea
gigas GN=CGI_10025706 PE=3 SV=1
Length = 650
Score = 278 bits (711), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 139/313 (44%), Positives = 198/313 (63%), Gaps = 18/313 (5%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW---GAGGSTADVTLD--IAKKMQN 74
+S EFFPP+T +G VNL+ R++RM P FCDITW G G+T T +A M N
Sbjct: 50 YSLEFFPPRTANGAVNLVSRIERMSEGGPMFCDITWHPAGDPGNTEKPTSSTCMAATMLN 109
Query: 75 TVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACAR 134
GVETM+H+TC+N + + L+ K GL+N+LALRGDPP G D + + E G A
Sbjct: 110 YCGVETMLHITCSNQDEDGLKRNLQKAKDIGLKNLLALRGDPPDGGDTWKKQEEGLNYAT 169
Query: 135 DLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIIT 194
DLVK IR +HGD+F I +AGYP HP++ Y +DL +LK KVDAGA+ IIT
Sbjct: 170 DLVKVIRREHGDHFTICVAGYPTGHPESTS---------YGDDLRHLKEKVDAGANFIIT 220
Query: 195 QLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPI 254
QLF+ + F +F DCR+IGITCPI+PG++PI Y+ + + ++P EI+ +EPI
Sbjct: 221 QLFFKPETFFQFLRDCREIGITCPIIPGVLPIQAYQSLRHIVKLSRLEVPKEILDTIEPI 280
Query: 255 KDNEEAVKAYGIHLGTEMCKKILAH-GFKTLHLYTLNLEKSALAILKNLGL-IEE--TSI 310
KDN+EA++ +G+ +MC+++L H +H YTLN E + + IL+ LG+ +EE +
Sbjct: 281 KDNDEAIRNFGVEQCFQMCRELLKHEDVHGVHFYTLNREVATIEILRRLGMWVEEPCKPL 340
Query: 311 PRTRPANAIQAKE 323
P + AN ++ KE
Sbjct: 341 PWKQTANYVRCKE 353
>E9BV23_LEIDB (tr|E9BV23) Methylenetetrahydrofolate reductase OS=Leishmania
donovani (strain BPK282A1) GN=LDBPK_366670 PE=3 SV=1
Length = 309
Score = 278 bits (710), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 131/301 (43%), Positives = 193/301 (64%), Gaps = 5/301 (1%)
Query: 11 AASDPNKVVFSFEFFPPKTEDGVVNLLERM-DRMVAHSPSFCDITWGAGGSTADVTLDIA 69
AA D +K S+E +PP++E ++++ + + SP F D+TWGAGG T+D T+ +
Sbjct: 10 AAEDVSKWYTSYELYPPRSEKAEEDMMKVLVPNFMRQSPVFLDLTWGAGGRTSDTTMRLC 69
Query: 70 KKMQNTV-GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEG 128
K +Q+ MH+TCTN P I++AL+ K++G++N+LALRGDPP G++ F
Sbjct: 70 KDLQHAYPDTPINMHITCTNTPKGLINEALDFAKTHGIRNILALRGDPPRGEE-FRADPD 128
Query: 129 GFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAG 188
GFACARDLV++I +GDYF +++AGYPE HP I +G + ED+Q +L YLK KVDAG
Sbjct: 129 GFACARDLVRYIHDTYGDYFCVSVAGYPEGHPSRIAEDGAISDEDHQKELEYLKEKVDAG 188
Query: 189 ADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIM 248
A IITQLFYD ++++F CR+IGIT PI+ G++PI Y GF+RM CKT +P+++
Sbjct: 189 ASFIITQLFYDASLYVQFVKRCREIGITVPILAGLLPITTYAGFVRMVSLCKTSVPSDVK 248
Query: 249 AALEPIKDNEEAVKAYGIHLGTEMCKKILAHG--FKTLHLYTLNLEKSALAILKNLGLIE 306
+E +K+N + +K YG+ +M + I G + LH YTLN +LK L +
Sbjct: 249 KRVEELKENPDGLKEYGVEQCVQMIECIRTSGLDYHHLHFYTLNNSAQTFKVLKRLNALV 308
Query: 307 E 307
E
Sbjct: 309 E 309
>A4IC95_LEIIN (tr|A4IC95) Methylenetetrahydrofolate reductase OS=Leishmania
infantum GN=LINJ_36_6670 PE=3 SV=1
Length = 309
Score = 278 bits (710), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 131/301 (43%), Positives = 193/301 (64%), Gaps = 5/301 (1%)
Query: 11 AASDPNKVVFSFEFFPPKTEDGVVNLLERM-DRMVAHSPSFCDITWGAGGSTADVTLDIA 69
AA D +K S+E +PP++E ++++ + + SP F D+TWGAGG T+D T+ +
Sbjct: 10 AAEDVSKWYTSYELYPPRSEKAEEDMMKVLVPNFMRQSPVFLDLTWGAGGRTSDTTMRLC 69
Query: 70 KKMQNTV-GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEG 128
K +Q+ MH+TCTN P I++AL+ K++G++N+LALRGDPP G++ F
Sbjct: 70 KDLQHAYPDTPINMHITCTNTPKGLINEALDFAKTHGIRNILALRGDPPRGEE-FRADPD 128
Query: 129 GFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAG 188
GFACARDLV++I +GDYF +++AGYPE HP I +G + ED+Q +L YLK KVDAG
Sbjct: 129 GFACARDLVRYIHDTYGDYFCVSVAGYPEGHPSRIAEDGAISDEDHQKELEYLKEKVDAG 188
Query: 189 ADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIM 248
A IITQLFYD ++++F CR+IGIT PI+ G++PI Y GF+RM CKT +P+++
Sbjct: 189 ASFIITQLFYDASLYVQFVKRCREIGITVPILAGLLPITTYAGFVRMVSLCKTSVPSDVK 248
Query: 249 AALEPIKDNEEAVKAYGIHLGTEMCKKILAHG--FKTLHLYTLNLEKSALAILKNLGLIE 306
+E +K+N + +K YG+ +M + I G + LH YTLN +LK L +
Sbjct: 249 KRVEELKENPDGLKEYGVEQCVQMIECIRTSGLDYHHLHFYTLNNSAQTFKVLKRLNALV 308
Query: 307 E 307
E
Sbjct: 309 E 309
>M7WNN9_RHOTO (tr|M7WNN9) Methylenetetrahydrofolate reductase (NADPH)
OS=Rhodosporidium toruloides NP11 GN=RHTO_04196 PE=4
SV=1
Length = 593
Score = 278 bits (710), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 140/307 (45%), Positives = 191/307 (62%), Gaps = 19/307 (6%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
+K+ +KI +A + +SFEFFPPKT +G VNL +R++RM P F DITWGAGGS
Sbjct: 2 VKISDKIKKAERE--GRPWWSFEFFPPKTPEGWVNLYDRIERMQQLGPIFVDITWGAGGS 59
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
T++ T + K + +G+ET MHLTCTNMPVE +E S G +N+LALRGDPP G
Sbjct: 60 TSEATTNFVKTAHSELGLETCMHLTCTNMPVE-----MEAYDS-GCRNILALRGDPPRGV 113
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+++ EGGF A DLVKHIR +GDYF I +AG+PE HP + E + ++ +
Sbjct: 114 EEWKPTEGGFNHAIDLVKHIRKNYGDYFCIGVAGFPEGHPQS---------ESPEAEIRH 164
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
K KVDAGAD++ TQ+FYD D+F+ + R GIT PIVPGIMPI + F R T F
Sbjct: 165 FKKKVDAGADIVFTQMFYDADVFIDWGRRLRAAGITIPIVPGIMPIQTFAAFKRRTDFAG 224
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH--GFKTLHLYTLNLEKSALAI 298
T +P E+ LEPIKD++ V+ G +MC+KIL G +H YT+NL + +
Sbjct: 225 TIVPKELWDLLEPIKDDDAKVREVGTEYVADMCRKILNADLGIHGIHCYTMNLSRGTEML 284
Query: 299 LKNLGLI 305
L+ + +
Sbjct: 285 LEEMQFV 291
>B8M3Q9_TALSN (tr|B8M3Q9) Methylenetetrahydrofolate reductase OS=Talaromyces
stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 /
NRRL 1006) GN=TSTA_038580 PE=3 SV=1
Length = 607
Score = 277 bits (709), Expect = 3e-72, Method: Compositional matrix adjust.
Identities = 135/295 (45%), Positives = 189/295 (64%), Gaps = 12/295 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ E S + SFE+FPPKT GV NL +RMDRM P+F D+TWGAGGS
Sbjct: 1 MHIGQKLQEQETS--GRPGISFEYFPPKTAQGVQNLYDRMDRMHDLGPAFIDVTWGAGGS 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+++T ++ + Q G+ET MHLTCT+MP E++D ALE+ + G N+LALRGDPP Q
Sbjct: 59 RSELTCEMVRIAQTVFGLETCMHLTCTDMPRERVDAALESAYNAGCTNILALRGDPPREQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGF A+DLVK+IR K+G++F I + GYPE D + L + +
Sbjct: 119 EKWEAAEGGFRYAKDLVKYIREKYGNHFDIGVGGYPEGADDNPDVDQL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG+ I+TQ+FYD D FL + + CR GI I+PGIMPI+ Y F+R + + K
Sbjct: 170 LKEKVDAGSSFIVTQMFYDVDNFLDWVSKCRAKGIKAAIIPGIMPISTYDAFMRRSNWTK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKS 294
+IP + + LEP+K ++ V+ G L EMC+K+LA G LH YT+NL ++
Sbjct: 230 IRIPPDWLDKLEPVKADDAKVREIGTKLVAEMCRKLLASGQIHHLHFYTMNLAQA 284
>B2B2M5_PODAN (tr|B2B2M5) Methylenetetrahydrofolate reductase OS=Podospora
anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC
10383) PE=3 SV=1
Length = 610
Score = 277 bits (708), Expect = 5e-72, Method: Compositional matrix adjust.
Identities = 137/292 (46%), Positives = 181/292 (61%), Gaps = 9/292 (3%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVE 79
FSFE+FPPKT GV NL +RM+RM P F DITWGAGG A++T ++ + Q +G+E
Sbjct: 18 FSFEYFPPKTTQGVQNLYDRMERMNNFGPKFIDITWGAGGRIAELTCEMVVQAQTYLGLE 77
Query: 80 TMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKH 139
T MHLTCT+M EK++DAL G N+LALRGDPP ++K+ EGGF ARDLV+H
Sbjct: 78 TCMHLTCTDMGEEKVNDALRKAYKAGCTNILALRGDPPREKEKWEAAEGGFRYARDLVQH 137
Query: 140 IRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYD 199
IR + ++F I +AGYPE D + L L +LK KVDAGA I+TQ+FYD
Sbjct: 138 IRKSYHEHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDAGATFIVTQMFYD 188
Query: 200 TDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++ R GI PI+PGIMPI Y F+R KIP E M LEP+K+++
Sbjct: 189 ADNFVRWVGKVRARGINVPIIPGIMPIATYASFLRRANHMNCKIPDEWMQRLEPVKNDDV 248
Query: 260 AVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
AV+ G L E+C+KILA G LH YT+NL ++ +L+ L + P
Sbjct: 249 AVRDIGKTLVAELCRKILAAGIHHLHFYTMNLAQATRMVLEELDWMPSPDRP 300
>G2Q3E8_THIHA (tr|G2Q3E8) Methylenetetrahydrofolate reductase OS=Thielavia
heterothallica (strain ATCC 42464 / BCRC 31852 / DSM
1799) GN=MYCTH_2314160 PE=3 SV=1
Length = 612
Score = 277 bits (708), Expect = 5e-72, Method: Compositional matrix adjust.
Identities = 142/312 (45%), Positives = 191/312 (61%), Gaps = 13/312 (4%)
Query: 1 MKVIEKIHEAAAS-DPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M + E + EA + +P+ FSFE+FPPKT GV NL +RM+RM P F DITWGAGG
Sbjct: 1 MHIREMLAEAERTGNPS---FSFEYFPPKTAQGVQNLYDRMERMYNFGPKFIDITWGAGG 57
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
A++T ++ + Q +G+E MHLTCT+M EK++DAL G N+LALRGDPP
Sbjct: 58 RIAELTCEMVVQAQTYLGLEACMHLTCTDMGEEKVNDALRKAYKAGCTNILALRGDPPRD 117
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
++K+ + F ARDLV HIR +G++F I +AGYPE D + L L
Sbjct: 118 KEKWEATDTKFRYARDLVAHIRKMYGNHFDIGVAGYPEGCDDNKDEDLL---------LD 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVD GA I+TQ+FYD D FL++ R+ GIT PIVPGIMPI Y F+R
Sbjct: 169 HLKEKVDMGASFIVTQMFYDVDNFLRWVGKVRERGITVPIVPGIMPIATYASFLRRANHM 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
KIP E MA LEP+K+++ AV+ G L +MC+KILA G + LH YT+NL ++ +L
Sbjct: 229 NCKIPEEWMAKLEPVKNDDVAVRDIGKVLVADMCRKILAAGIRHLHFYTMNLAQATRMVL 288
Query: 300 KNLGLIEETSIP 311
+ L + P
Sbjct: 289 EELDWLPSPERP 300
>J9VRV0_CRYNH (tr|J9VRV0) Methylenetetrahydrofolate reductase OS=Cryptococcus
neoformans var. grubii serotype A (strain H99 / ATCC
208821 / CBS 10515 / FGSC 9487) GN=CNAG_05140 PE=3 SV=1
Length = 617
Score = 276 bits (707), Expect = 5e-72, Method: Compositional matrix adjust.
Identities = 137/307 (44%), Positives = 190/307 (61%), Gaps = 10/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ EK+ +A + +SFEFFPP+T G+ NL +R++RM P F DITWGAGG
Sbjct: 1 MKITEKLQKAEKE--GRPFWSFEFFPPRTAQGLQNLYDRIERMRDLGPEFIDITWGAGGK 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
AD+T + + Q T+G+ET MHL CT MP EK++ AL+ KS+G QN+LALRGDP G
Sbjct: 59 NADLTNSLVQVCQATIGIETCMHLCCTEMPKEKVEWALKEAKSHGCQNILALRGDPVAGT 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ GGF A DLV++I + F + +AG+P+ HP+ TPE ++ +
Sbjct: 119 STWEPTPGGFMNAVDLVRYIHKHYPGDFCVAVAGFPQGHPETPD-----TPEGRAQEMEW 173
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+KVDAGA+ I TQ+FYDT IF + R+ GI PI+PGIMPI N++ F +
Sbjct: 174 LKAKVDAGAEFIFTQMFYDTSIFFDWVKRVREAGINAPIIPGIMPIQNWEKFEKWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALA 297
+P+ AL P++ ++E V+ G L +MCK ILA+ G K LH+YTLNLEK A
Sbjct: 234 IIVPSHFYEALNPVRGDDEKVRQVGTKLVADMCKTILANKEAGIKGLHIYTLNLEKGARM 293
Query: 298 ILKNLGL 304
+L+ LG
Sbjct: 294 LLQELGF 300
>M3D6H6_9PEZI (tr|M3D6H6) Methylenetetrahydrofolate reductase OS=Mycosphaerella
populorum SO2202 GN=SEPMUDRAFT_133001 PE=3 SV=1
Length = 641
Score = 276 bits (706), Expect = 7e-72, Method: Compositional matrix adjust.
Identities = 138/313 (44%), Positives = 188/313 (60%), Gaps = 13/313 (4%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + EK+ +A + + SFE+FPPKT GV NL +RMD M P+F D+TWGAGG
Sbjct: 1 MHITEKLRQAHSK--GQATCSFEYFPPKTAQGVQNLYDRMDMMHGLGPAFIDVTWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ K Q G+ET MHLTCT+M KIDDAL+ G N+LALRGDPP Q
Sbjct: 59 HSSLTCEMVKVAQTAYGLETCMHLTCTDMERSKIDDALKEAYKAGCTNILALRGDPPREQ 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ EGGF A+DL+ HI+ +GD+F I IAGYPE + G++ + Y
Sbjct: 119 EKWEATEGGFRYAKDLIVHIKKTYGDHFDIGIAGYPEGLDETCGAD---------EHIIY 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGI--TCPIVPGIMPINNYKGFIRMTGF 238
LK KV+AG I+ Q+ YD DIF+ + CR GI T PI+PGIMPI+ Y F+R +
Sbjct: 170 LKEKVEAGGTFIVAQMCYDADIFIDWVKKCRAAGIPETVPIIPGIMPISTYAAFLRRANW 229
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAI 298
K +P M ALEPIK+++ AV+ G L E C+K+L G LH YT+NL ++ +
Sbjct: 230 TKAHVPPHWMEALEPIKNDDAAVREVGRDLIVEFCQKLLDFGLMHLHFYTMNLAQAVTMV 289
Query: 299 LKNLGLIEETSIP 311
L+ L L+ P
Sbjct: 290 LEKLDLLPPAESP 302
>B6K4Z7_SCHJY (tr|B6K4Z7) Methylenetetrahydrofolate reductase
OS=Schizosaccharomyces japonicus (strain yFS275 /
FY16936) GN=SJAG_03712 PE=3 SV=1
Length = 605
Score = 276 bits (706), Expect = 7e-72, Method: Compositional matrix adjust.
Identities = 138/308 (44%), Positives = 195/308 (63%), Gaps = 12/308 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDITWGAGG 59
MK+ +K+ D +V +S+E+FPPKT GVVNL R++RM P+F D+TWGAGG
Sbjct: 1 MKITDKLQLPEYRD--RVTWSYEYFPPKTSTGVVNLYNRIERMRDWGHPTFVDVTWGAGG 58
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
S++D+T I K Q+ G++T MHLTCTNM ++ID+ALE G +N+LALRGDP
Sbjct: 59 SSSDLTPVIVKVTQSDYGLDTCMHLTCTNMATKQIDEALERAYKVGCRNILALRGDPVKH 118
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ ++ +EGGF A DLV+HIR K+GD F I +AGYPE G A +D +
Sbjct: 119 ESEWTALEGGFEYACDLVRHIRKKYGDEFCIGVAGYPE---------GYAPGDDIDATIK 169
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
+LK KVD GA I+TQ+FYD + F+ + R GIT PI PGIMPI ++ F R +
Sbjct: 170 HLKIKVDEGASFIVTQMFYDAENFVDWVKRVRAAGITIPIFPGIMPIQSWSTFNRRCEWS 229
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAIL 299
+IP + ALEP+KD++ V+ G L EMC+K++ +G LH YT+NLEK+ I+
Sbjct: 230 GVRIPQHFIDALEPLKDDDALVREKGSELMAEMCQKLVDNGITRLHFYTMNLEKATKMII 289
Query: 300 KNLGLIEE 307
+ +GL+ +
Sbjct: 290 EKMGLLNQ 297
>E4UPV6_ARTGP (tr|E4UPV6) Methylenetetrahydrofolate reductase OS=Arthroderma
gypseum (strain ATCC MYA-4604 / CBS 118893)
GN=MGYG_02935 PE=3 SV=1
Length = 614
Score = 276 bits (706), Expect = 8e-72, Method: Compositional matrix adjust.
Identities = 148/295 (50%), Positives = 192/295 (65%), Gaps = 9/295 (3%)
Query: 21 SFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTVGVET 80
SFEFFPPKT GV NL +RMDRM PSF DITWGAGG A++T ++ Q+ G+ET
Sbjct: 19 SFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVYGLET 78
Query: 81 MMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDLVKHI 140
MHLTCT+MP EK+D+AL++ G N+LALRGDPP ++ + Q EGGF ARDLV++I
Sbjct: 79 CMHLTCTDMPREKVDEALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDLVQYI 138
Query: 141 RAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDT 200
R K+G++F I +AGYPE G ED + + YLK KVDAG IITQ+FYD
Sbjct: 139 REKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQMFYDA 189
Query: 201 DIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEA 260
D F+ + CRQ GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+++ A
Sbjct: 190 DNFIAWVRKCRQAGIKIPIIPGIMPISTYAAFIRRTKWVKCAVPKGWMEALEPVKNDDAA 249
Query: 261 VKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIPRTRP 315
VK G L EMC+K+L +G LH YT+NL +S +L+ L L + P +P
Sbjct: 250 VKHIGKALVAEMCRKLLDNGINHLHFYTMNLAQSTSMVLEELNLKPSSETPLQKP 304
>H2MXI6_ORYLA (tr|H2MXI6) Methylenetetrahydrofolate reductase OS=Oryzias latipes
GN=LOC101173920 PE=3 SV=1
Length = 657
Score = 276 bits (705), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 147/307 (47%), Positives = 190/307 (61%), Gaps = 18/307 (5%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW---GAGGSTADVT-LDIAKKMQNT 75
FS EFFPP+T G VNL+ R DRM A P F D+TW G GS + + + IA N
Sbjct: 62 FSLEFFPPRTASGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 121
Query: 76 VGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARD 135
G+E+++HLTC N EKI L K GL+N++ALRGDP G D + + E GF A D
Sbjct: 122 CGLESVLHLTCCNQTKEKITGYLAKAKHLGLKNIMALRGDP-IGTD-WEEEEEGFNFAVD 179
Query: 136 LVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQ 195
LVKHIR++ DYF I +AGYP HP+A + Y++DL +LK KVDAGAD +ITQ
Sbjct: 180 LVKHIRSEFDDYFDICVAGYPTGHPEA---------DSYEDDLRHLKDKVDAGADFVITQ 230
Query: 196 LFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ D FLKF +DCR IGITCPI+PGI PI Y+ ++ K ++P +I +EPIK
Sbjct: 231 LFFRADTFLKFLDDCRAIGITCPILPGIFPIQGYQSLRQLVKLSKLEVPEDITKVIEPIK 290
Query: 256 DNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAILKNLGLIEETSIPRTR 314
DN+ A++ YGIHL EMC +L G LH YTLN E + + +L+ LGL E PR
Sbjct: 291 DNDAAIRNYGIHLAVEMCSVLLESGNVPGLHFYTLNREVATMEVLRQLGLWLED--PRRP 348
Query: 315 PANAIQA 321
A+ A
Sbjct: 349 LPWAVSA 355
>G3AY82_CANTC (tr|G3AY82) Methylenetetrahydrofolate reductase OS=Candida tenuis
(strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 /
NBRC 10315 / NRRL Y-1498 / VKM Y-70)
GN=CANTEDRAFT_118482 PE=3 SV=1
Length = 614
Score = 275 bits (704), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 149/311 (47%), Positives = 205/311 (65%), Gaps = 18/311 (5%)
Query: 1 MKVIEKIHEA-AASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
M++ EK+++A ++S+P FSFEFF PKT GV NL +RMDRM +P F DITW AGG
Sbjct: 1 MRISEKLNQAYSSSNPPPATFSFEFFVPKTSQGVQNLYDRMDRMYELNPIFIDITWNAGG 60
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
++ +T ++ Q+ +G+ET MHLTCTNM V ID+ALE K +G QN+LALRGDPP
Sbjct: 61 RSSSLTNEMVYTAQSALGLETCMHLTCTNMSVSLIDEALERAKKSGCQNILALRGDPPLD 120
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ G F A+DL+ +IR +G+YF I +A YPE H PE+ DLT
Sbjct: 121 G---TESTGDFKYAKDLILYIRKNYGNYFNIGVAAYPEGH-----------PEESDLDLT 166
Query: 180 --YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
YLK K DAGAD IITQ+FYDTD F+++ + R+IG+ PI+PGIMPI+ Y F+R
Sbjct: 167 VKYLKDKCDAGADFIITQMFYDTDNFIEWCSKVRKIGVDIPIIPGIMPISTYAAFMRRAK 226
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSAL 296
+ + K+P + LEPIKD++ V+ G L ++MC K+L G+ K LH YT+NLE+S +
Sbjct: 227 WSEIKVPKHFLDVLEPIKDDDFLVREKGTELVSQMCTKLLESGYVKHLHFYTMNLERSTI 286
Query: 297 AILKNLGLIEE 307
L+NLGLI++
Sbjct: 287 MCLENLGLIDQ 297
>D5GMM8_TUBMM (tr|D5GMM8) Methylenetetrahydrofolate reductase OS=Tuber
melanosporum (strain Mel28) GN=GSTUM_00010817001 PE=3
SV=1
Length = 600
Score = 275 bits (704), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 142/311 (45%), Positives = 188/311 (60%), Gaps = 13/311 (4%)
Query: 17 KVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKKMQNTV 76
+ FSFE+F PKT GV NL +RMDRM P F DITW AGG +++T ++ Q+
Sbjct: 17 RPTFSFEYFVPKTAQGVQNLYDRMDRMNQLGPQFIDITWNAGGRLSNLTCEMVNVAQSVY 76
Query: 77 GVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFACARDL 136
G+ET MHLTCT MP K+D+AL+ G N+LALRGDPP +K+ GF A+DL
Sbjct: 77 GIETCMHLTCTGMPKSKVDNALKEAYKAGCTNILALRGDPPRENEKWEADPHGFRYAKDL 136
Query: 137 VKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQL 196
VK+I++ +G++F I +AGYPE D L L +LK KVDAGA IITQ+
Sbjct: 137 VKYIKSNYGNHFDIHVAGYPEGCDDGTDPELL---------LEHLKEKVDAGASSIITQM 187
Query: 197 FYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIFL + CR IGIT PI+PGIMPI+ Y F+R + K IP + + LEP+K+
Sbjct: 188 FYDVDIFLDWVRKCRDIGITVPIIPGIMPIHTYAAFMRRATWTKCHIPEKWLYLLEPVKN 247
Query: 257 NEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLI----EETSIPR 312
++ AV+ G L E+C+KI+ G LH YT+NL + L+ LGLI E T
Sbjct: 248 DDVAVRDIGRDLMVELCQKIIDAGILHLHFYTMNLATATRMCLEGLGLIPSLQERTKALP 307
Query: 313 TRPANAIQAKE 323
RP+ + KE
Sbjct: 308 FRPSLGLNRKE 318
>H2YN67_CIOSA (tr|H2YN67) Methylenetetrahydrofolate reductase (Fragment) OS=Ciona
savignyi GN=Csa.2215 PE=3 SV=1
Length = 609
Score = 275 bits (703), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 141/308 (45%), Positives = 184/308 (59%), Gaps = 21/308 (6%)
Query: 3 VIEKI-HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW----GA 57
+ EKI + DP FS EFFPP+TE G NL+ R DRM P F DITW
Sbjct: 5 LTEKILSRVKSKDP---FFSLEFFPPRTEQGAANLIGRFDRMRQGGPLFVDITWHPAGDP 61
Query: 58 GGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP 117
GG + IA + N ++TM+H+TC E I LE K+ G++N+LALRGD
Sbjct: 62 GGDKITSSTKIAGTVLNYCSLDTMLHMTCVKQTEETIKKNLEKTKNLGIRNILALRGD-- 119
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
+ + EGGF DLV+ I+ ++GDYF I +AGYP HPD+ YQ D
Sbjct: 120 -ADENWGITEGGFNYGVDLVRFIKKEYGDYFSICVAGYPNGHPDSTS---------YQED 169
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
L +LK K+DAG + +ITQLF+ D FL F DCR+IGITCPI+PGI PI + +++T
Sbjct: 170 LLHLKEKIDAGGEFVITQLFFTADEFLTFVKDCREIGITCPIIPGIFPIQTNRSLVQLTK 229
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSAL 296
K IP EI +EPIKDN+ A++ YGI L T+MC+ +L G LH+YTLNLE + +
Sbjct: 230 LSKLTIPEEIQKVIEPIKDNDAAIRKYGIDLATDMCRSLLNSGEVHGLHMYTLNLEAATI 289
Query: 297 AILKNLGL 304
ILKNLGL
Sbjct: 290 QILKNLGL 297
>E4ZHE6_LEPMJ (tr|E4ZHE6) Methylenetetrahydrofolate reductase OS=Leptosphaeria
maculans (strain JN3 / isolate v23.1.3 / race
Av1-4-5-6-7-8) GN=LEMA_P057500.1 PE=3 SV=1
Length = 670
Score = 275 bits (703), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 134/306 (43%), Positives = 188/306 (61%), Gaps = 9/306 (2%)
Query: 10 AAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIA 69
A A + K FSFEFFPPKT GV NL +RMDRM P F DITWGAGG + +T ++
Sbjct: 8 AQAREDGKPTFSFEFFPPKTAQGVQNLYDRMDRMHGFGPQFIDITWGAGGRHSKLTCEMV 67
Query: 70 KKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGG 129
K Q+ G+ET MHLTCT+M K+D+AL +G N+LALRGDPP ++K+ GG
Sbjct: 68 KVAQSVYGLETCMHLTCTDMEKSKLDEALRDAYQSGCTNILALRGDPPREREKWEATAGG 127
Query: 130 FACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGA 189
F A+DLV +IR ++G++F I +AGY E D + L + +LK KVDAGA
Sbjct: 128 FRYAKDLVVYIRERYGNHFDIGVAGYSEGSDDNDNVDEL---------IDHLKEKVDAGA 178
Query: 190 DLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMA 249
I+TQ+FYDTDIFL++ R G+ PI+PGIMPI+ + F+R + + IP
Sbjct: 179 TFIVTQMFYDTDIFLEWVRKVRAKGVDVPIIPGIMPIHTHAAFLRRAQWTRCNIPQHWTE 238
Query: 250 ALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETS 309
ALEP+K+++ V+ G L +MC+K++ G LH YT+NL ++ +L+ L L+ +
Sbjct: 239 ALEPVKNDDVEVREVGKGLVADMCRKLIDAGILHLHFYTMNLAQATRMVLEELELLPDQR 298
Query: 310 IPRTRP 315
P +P
Sbjct: 299 SPLEKP 304
>R7UHV3_9ANNE (tr|R7UHV3) Uncharacterized protein OS=Capitella teleta
GN=CAPTEDRAFT_181552 PE=4 SV=1
Length = 654
Score = 275 bits (703), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 141/330 (42%), Positives = 199/330 (60%), Gaps = 20/330 (6%)
Query: 2 KVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGST 61
++I++I++ + FS EFFPP+T +G VNL+ R DRM P FCDITW G
Sbjct: 39 RLIDRINDRVQA--GSKFFSLEFFPPRTANGAVNLISRFDRMAMGRPLFCDITWHPAGDP 96
Query: 62 AD----VTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP 117
+ IA M N G+ETM+H+TC + ++I + L K+ G++N+LALRGDPP
Sbjct: 97 GSDKPTSSTSIANSMVNYCGLETMLHITCCGLTKQQITNHLTKAKNLGIRNILALRGDPP 156
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
G +++ E GF DLV+HIR GD+F I +AGYP HPD+ Y+ D
Sbjct: 157 -GDEEWKAPEDGFNFGTDLVRHIREVFGDHFVIAVAGYPTGHPDS---------PSYEED 206
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
L ++K KVDAGAD IITQLF+ + FLK+ +DCR IGI+ PI+PGI+PI Y+ +
Sbjct: 207 LQHMKEKVDAGADFIITQLFFKAETFLKYVSDCRAIGISVPIMPGILPIQAYQSLRHIVK 266
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSAL 296
+ ++P +I+ + PIKDN+EA++ YGI TEMC+ +L G LH YTLN E + +
Sbjct: 267 LSRLEVPDDIIDTITPIKDNDEAIRNYGIFQATEMCRDLLDSGSIHGLHFYTLNREVATI 326
Query: 297 AILKNLGLIEE---TSIPRTRPANAIQAKE 323
+LK LG+ E S+P AN + KE
Sbjct: 327 QVLKALGMWCEDPRRSLPWKTTANHNRCKE 356
>B7GB47_PHATC (tr|B7GB47) Methylenetetrahydrofolate reductase (Fragment)
OS=Phaeodactylum tricornutum (strain CCAP 1055/1)
GN=PHATRDRAFT_30471 PE=3 SV=1
Length = 376
Score = 275 bits (703), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 146/340 (42%), Positives = 192/340 (56%), Gaps = 53/340 (15%)
Query: 16 NKVVFSFEFFPPKTEDGVVNLLERMDRMV-AHSPSFCDITWGAGGSTADVTLDIAKKMQN 74
K S E+FPP+T +GV NL RM RM P+F D+TWGAGGSTA+++L +A N
Sbjct: 38 GKPFVSLEYFPPRTAEGVQNLHARMHRMRDTLQPAFTDMTWGAGGSTAELSLQLALYAHN 97
Query: 75 TVGVETMMHLTCTNM---------------------------PVEKIDDALETIKSNGLQ 107
T G +H+TCTN+ P E + AL+ G++
Sbjct: 98 T-GHVANLHMTCTNLDSGKSSTSTSSSSEHNGNASDDVASADPRETLRRALQQAHDGGIR 156
Query: 108 NVLALRGDPPHGQDKFVQVEGGFACARDLVKHIRA--KHGDYFGITIAGYPEAHPDAI-- 163
N++ALRGDPP GQ+ + EGGF CA DLV+ IR+ G F + +AGYPE HP+AI
Sbjct: 157 NLVALRGDPPAGQETWTATEGGFTCALDLVEFIRSLPDIGADFHLAVAGYPEGHPNAISE 216
Query: 164 -------------------GSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFL 204
G DY ++ YLK KVDAG D+I+TQ+F+D +FL
Sbjct: 217 IADPTTLTAAEAARASVTDGKTYCCLDADYHKEMEYLKKKVDAGGDMIMTQMFFDAAVFL 276
Query: 205 KFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAY 264
+F DCR GIT PIVPG+M IN Y GF++M FCKT++P + A +E IKD+ AVKA+
Sbjct: 277 QFVEDCRAWGITVPIVPGLMCINAYAGFVKMAKFCKTRVPETLRARMEAIKDDAAAVKAF 336
Query: 265 GIHLGTEMCKKILAHG-FKTLHLYTLNLEKSALAILKNLG 303
G+ G EMC+ +LA G LH YTLNLEK +L LG
Sbjct: 337 GVEFGVEMCRTLLASGHVSVLHFYTLNLEKVVYGVLDALG 376
>H2YN66_CIOSA (tr|H2YN66) Methylenetetrahydrofolate reductase OS=Ciona savignyi
GN=Csa.2215 PE=3 SV=1
Length = 558
Score = 275 bits (703), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 141/308 (45%), Positives = 184/308 (59%), Gaps = 21/308 (6%)
Query: 3 VIEKI-HEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITW----GA 57
+ EKI + DP FS EFFPP+TE G NL+ R DRM P F DITW
Sbjct: 17 LTEKILSRVKSKDP---FFSLEFFPPRTEQGAANLIGRFDRMRQGGPLFVDITWHPAGDP 73
Query: 58 GGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPP 117
GG + IA + N ++TM+H+TC E I LE K+ G++N+LALRGD
Sbjct: 74 GGDKITSSTKIAGTVLNYCSLDTMLHMTCVKQTEETIKKNLEKTKNLGIRNILALRGD-- 131
Query: 118 HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQND 177
+ + EGGF DLV+ I+ ++GDYF I +AGYP HPD+ YQ D
Sbjct: 132 -ADENWGITEGGFNYGVDLVRFIKKEYGDYFSICVAGYPNGHPDSTS---------YQED 181
Query: 178 LTYLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTG 237
L +LK K+DAG + +ITQLF+ D FL F DCR+IGITCPI+PGI PI + +++T
Sbjct: 182 LLHLKEKIDAGGEFVITQLFFTADEFLTFVKDCREIGITCPIIPGIFPIQTNRSLVQLTK 241
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHG-FKTLHLYTLNLEKSAL 296
K IP EI +EPIKDN+ A++ YGI L T+MC+ +L G LH+YTLNLE + +
Sbjct: 242 LSKLTIPEEIQKVIEPIKDNDAAIRKYGIDLATDMCRSLLNSGEVHGLHMYTLNLEAATI 301
Query: 297 AILKNLGL 304
ILKNLGL
Sbjct: 302 QILKNLGL 309
>Q5K8Q9_CRYNJ (tr|Q5K8Q9) Methylenetetrahydrofolate reductase OS=Cryptococcus
neoformans var. neoformans serotype D (strain JEC21 /
ATCC MYA-565) GN=CNL04820 PE=3 SV=1
Length = 617
Score = 274 bits (701), Expect = 3e-71, Method: Compositional matrix adjust.
Identities = 136/307 (44%), Positives = 188/307 (61%), Gaps = 10/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ EK+ +A + +SFEFFPP+T G+ NL +R++RM P F DITWGAGG
Sbjct: 1 MKITEKLQKAEKE--GRPFWSFEFFPPRTAQGLQNLYDRIERMRDLGPEFIDITWGAGGK 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
AD+T + + Q T+G+ET MHL CT MP EK++ AL KS+G QN+LALRGDP G
Sbjct: 59 NADLTNSLVQVCQATIGIETCMHLCCTEMPKEKVEWALREAKSHGCQNILALRGDPVAGT 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ GGF A DLV++I + F + +AG+P+ HP+ TPE ++ +
Sbjct: 119 STWEPTPGGFMNAVDLVRYIHEHYPGDFCVAVAGFPQGHPETPD-----TPEGRAQEMEW 173
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+KVDAGA+ I TQ+FYDT IF + R+ GI PI+PGIMPI N++ F +
Sbjct: 174 LKAKVDAGAEFIFTQMFYDTSIFFDWVKRVREAGINVPIIPGIMPIQNWEKFEKWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALA 297
+P+ AL P++ ++E V+ G L +MCK IL + G K LH+YTLNLEK A
Sbjct: 234 IIVPSHFYEALNPVRGDDEKVRQVGTKLVADMCKTILDNKEAGIKGLHIYTLNLEKGARM 293
Query: 298 ILKNLGL 304
+L+ LG
Sbjct: 294 LLRELGF 300
>F5HGC8_CRYNB (tr|F5HGC8) Methylenetetrahydrofolate reductase OS=Cryptococcus
neoformans var. neoformans serotype D (strain B-3501A)
GN=CNBI2020 PE=3 SV=1
Length = 617
Score = 274 bits (701), Expect = 3e-71, Method: Compositional matrix adjust.
Identities = 136/307 (44%), Positives = 188/307 (61%), Gaps = 10/307 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
MK+ EK+ +A + +SFEFFPP+T G+ NL +R++RM P F DITWGAGG
Sbjct: 1 MKITEKLQKAEKE--GRPFWSFEFFPPRTAQGLQNLYDRIERMRDLGPEFIDITWGAGGK 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
AD+T + + Q T+G+ET MHL CT MP EK++ AL KS+G QN+LALRGDP G
Sbjct: 59 NADLTNSLVQVCQATIGIETCMHLCCTEMPKEKVEWALREAKSHGCQNILALRGDPVAGT 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+ GGF A DLV++I + F + +AG+P+ HP+ TPE ++ +
Sbjct: 119 STWEPTPGGFMNAVDLVRYIHEHYPGDFCVAVAGFPQGHPETPD-----TPEGRAQEMEW 173
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+KVDAGA+ I TQ+FYDT IF + R+ GI PI+PGIMPI N++ F +
Sbjct: 174 LKAKVDAGAEFIFTQMFYDTSIFFDWVKRVREAGINVPIIPGIMPIQNWEKFEKWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAH---GFKTLHLYTLNLEKSALA 297
+P+ AL P++ ++E V+ G L +MCK IL + G K LH+YTLNLEK A
Sbjct: 234 IIVPSHFYEALNPVRGDDEKVRQVGTKLVADMCKTILDNKEAGIKGLHIYTLNLEKGARM 293
Query: 298 ILKNLGL 304
+L+ LG
Sbjct: 294 LLRELGF 300
>B8BRT9_THAPS (tr|B8BRT9) Methylenetetrahydrofolate reductase (Fragment)
OS=Thalassiosira pseudonana GN=THAPSDRAFT_13444 PE=3
SV=1
Length = 574
Score = 274 bits (700), Expect = 3e-71, Method: Compositional matrix adjust.
Identities = 138/294 (46%), Positives = 188/294 (63%), Gaps = 17/294 (5%)
Query: 20 FSFEFFPPKTEDGVVNLLERMDRMVAH-SPSFCDITWGAGGSTADVTLDIAKKMQNTVGV 78
+SFEFFPPKTE G+ NLL R+DRM P F ITWG+ GST TL +A Q V
Sbjct: 1 YSFEFFPPKTEPGLDNLLTRIDRMCRRLDPLFVSITWGSNGSTLSRTLAVASHAQRFACV 60
Query: 79 ETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQ--VEGGFACAR-- 134
+ ++HL+CT + E+I L KS+G+ N+LALRGDPP G+ + + V GG C R
Sbjct: 61 DVLLHLSCTGLTREQIGHVLAMAKSSGVHNILALRGDPPQGKRAWKEGDVSGG-ECDRAI 119
Query: 135 DLVKHIRAKHGDYFGITIAGYPEAHPDAI-GSNGLATPEDYQNDLTYLKSKVDAGADLII 193
DLVK IR HG+YFGI +AG+PE HP + G NG A ++ +LK K+DAGAD +I
Sbjct: 120 DLVKLIRRLHGNYFGIGVAGHPEGHPSSQKGDNGKAL------EMQHLKEKLDAGADFVI 173
Query: 194 TQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEP 253
+Q FYD ++FL + CR++GI CPI+PGIMP+ +Y ++MT FC +P+ +M L
Sbjct: 174 SQFFYDVNVFLDYVKRCRKVGIDCPIIPGIMPVQSYSSLVKMTQFCGISVPSAVMDRLSN 233
Query: 254 IKDNEEAVKAYGIHLGTEMCKKILAHGFKT----LHLYTLNLEKSALAILKNLG 303
I+ ++EAVK G + EMC++IL+ G + H YTLNLE+S IL +LG
Sbjct: 234 IRLDDEAVKQVGCKIVAEMCEQILSAGLEVDVDGFHFYTLNLERSTTRILTSLG 287
>G8BYR2_TETPH (tr|G8BYR2) Methylenetetrahydrofolate reductase OS=Tetrapisispora
phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
Y-8282 / UCD 70-5) GN=TPHA0J01830 PE=3 SV=1
Length = 649
Score = 273 bits (699), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 144/335 (42%), Positives = 192/335 (57%), Gaps = 39/335 (11%)
Query: 1 MKVIEKIHEAAASDPN-----KVVFSFEFFPPKTEDGVVNLLERMDRMVAHS-PSFCDIT 54
M++ EK+ + + N FSFE+F P+T GV NL +RMDRM S P F D+T
Sbjct: 1 MRITEKLVRSNGDESNGNATTAATFSFEYFVPRTTQGVHNLYDRMDRMYQESLPQFIDVT 60
Query: 55 WGAGGSTADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRG 114
W AGG ++T +I Q+ +G+ET MHLTCTNM + ID AL+ +G QN+LALRG
Sbjct: 61 WNAGGVNNNLTNEIVFTAQSVLGLETCMHLTCTNMDITTIDKALQQAYESGCQNILALRG 120
Query: 115 DPP-----------------------HGQDKFVQVEGGFACARDLVKHIRAKHGDYFGIT 151
DPP D G F A+DLV +IR K+GDYF I
Sbjct: 121 DPPLTNVGDSVGKSGNGGVGGADITDGNADADTAASGVFHYAKDLVGYIRLKYGDYFDIG 180
Query: 152 IAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADLIITQLFYDTDIFLKFANDCR 211
+AGYPE H + S L +LK K+D GA+ I+TQ+FYD D FL + R
Sbjct: 181 VAGYPEGHEEEKDSQLLTK---------FLKEKIDCGANFIVTQMFYDVDNFLNWCKLLR 231
Query: 212 QIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTE 271
+ GI PI+PG+MPI+ Y F+R +CK IP E + LEP+KD++EAV+ G L +
Sbjct: 232 ENGINVPIIPGVMPISTYAAFLRRARWCKINIPDEFLRKLEPVKDDDEAVREVGTQLLVD 291
Query: 272 MCKKILAHGFKT-LHLYTLNLEKSALAILKNLGLI 305
MC+KIL G+ + LHLYT+NLEK+ L IL L L+
Sbjct: 292 MCRKILDSGYVSHLHLYTMNLEKAPLMILDKLNLL 326
>R0K2D2_SETTU (tr|R0K2D2) Uncharacterized protein OS=Setosphaeria turcica Et28A
GN=SETTUDRAFT_93247 PE=4 SV=1
Length = 654
Score = 273 bits (699), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 136/315 (43%), Positives = 193/315 (61%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ A A K FSFEFFPPKT GV NL +RMDRM + P F D+TWGAGG
Sbjct: 1 MHISQKL--AQAKREGKPTFSFEFFPPKTAQGVQNLYDRMDRMHSFGPQFIDLTWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ K Q+ G+ET MHLTCT+M K+DDAL+ G N+LALRGDPP +
Sbjct: 59 HSKLTCEMVKVAQSVYGLETCMHLTCTDMEKSKLDDALKEAYQAGCTNILALRGDPPRER 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ GGF A+DLV +I+ K+G++F I +AGY E D + L + +
Sbjct: 119 EKWEATAGGFRYAKDLVVYIKEKYGNHFDIGVAGYSEGCDDNDNVDEL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA ++TQ+FYDTDIFL++ R GI PI+PGIMPI+ + F+R + +
Sbjct: 170 LKEKVDAGATFVVTQMFYDTDIFLEWVRKVRAKGIDVPIIPGIMPIHTHAAFLRRAQWTR 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IP ALEPIK+++ V+ G L +MC++++ G LH YT+NL ++ +L+
Sbjct: 230 CHIPKHWEEALEPIKNDDVEVREVGKTLVADMCRRLIEAGITHLHFYTMNLAQATRMVLE 289
Query: 301 NLGLIEETSIPRTRP 315
L L+ + P +P
Sbjct: 290 ELELLPDVESPLEKP 304
>B2WMV1_PYRTR (tr|B2WMV1) Methylenetetrahydrofolate reductase OS=Pyrenophora
tritici-repentis (strain Pt-1C-BFP) GN=PTRG_11311 PE=3
SV=1
Length = 646
Score = 273 bits (698), Expect = 6e-71, Method: Compositional matrix adjust.
Identities = 133/304 (43%), Positives = 185/304 (60%), Gaps = 9/304 (2%)
Query: 12 ASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGSTADVTLDIAKK 71
A + K FSFEFFPPKT GV NL +RMDRM P F D+TWGAGG + +T ++ K
Sbjct: 10 AREEGKPTFSFEFFPPKTAQGVQNLYDRMDRMHGFGPQFIDLTWGAGGRHSKLTCEMVKV 69
Query: 72 MQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQDKFVQVEGGFA 131
Q G+ET MHLTCT+M K+DDAL +G N+LALRGDPP ++K+ GGF
Sbjct: 70 AQTVYGLETCMHLTCTDMEKSKLDDALREAYQSGCTNILALRGDPPREREKWEATAGGFR 129
Query: 132 CARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTYLKSKVDAGADL 191
A+DLV +I+ K+G++F I +AGY E D + L + +LK KVDAG
Sbjct: 130 YAKDLVVYIKEKYGNHFDIGVAGYSEGSDDNDNVDEL---------IDHLKEKVDAGGTF 180
Query: 192 IITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAAL 251
I+TQ+FYD DIFL++ R GI PI+PGIMPI+ + F+R + + IP AL
Sbjct: 181 IVTQMFYDVDIFLEWVRKVRAKGIDVPIIPGIMPIHTHAAFLRRAQWTRCNIPQHWTDAL 240
Query: 252 EPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILKNLGLIEETSIP 311
EP+K+++ V+ G L +MC+K++A G LH YT+NL ++ +L+ L L+ + P
Sbjct: 241 EPVKNDDVEVREVGKMLVADMCRKLIAAGITHLHFYTMNLAQATRMVLEELDLLPDVEAP 300
Query: 312 RTRP 315
+P
Sbjct: 301 LEKP 304
>B9WDQ7_CANDC (tr|B9WDQ7) Methylenetetrahydrofolate reductase OS=Candida
dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 /
NCPF 3949 / NRRL Y-17841) GN=CD36_82930 PE=3 SV=1
Length = 614
Score = 273 bits (698), Expect = 7e-71, Method: Compositional matrix adjust.
Identities = 151/308 (49%), Positives = 199/308 (64%), Gaps = 14/308 (4%)
Query: 1 MKVIEKIHEA-AASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
MK+ EK+ +A S P FSFEFF PKT GV NL +RMDRM +P F DITW AGG
Sbjct: 1 MKISEKLSQAHRGSKPPPATFSFEFFVPKTSQGVQNLYDRMDRMYDLNPIFIDITWNAGG 60
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
++ +T ++ Q+T+G+ET MHLTCTNM VE ID+ALE +G QN+LALRGDPP
Sbjct: 61 RSSTLTNEMVYTAQSTLGLETCMHLTCTNMKVELIDEALEKAYKSGCQNILALRGDPPLD 120
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ G F A+DL+K+I K+G++F I +AGYPE HP+ ED Q L
Sbjct: 121 GS---ESTGDFKYAKDLIKYIHKKYGNHFNIGVAGYPEGHPEE---------EDEQKTLQ 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK K DAGAD IITQ+FYD + F+ + + R+IG+ PI+PGIMPI+ Y FIR +
Sbjct: 169 YLKEKCDAGADFIITQMFYDVENFVSWCSKLRKIGVDIPIIPGIMPISTYAAFIRRAKWS 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSALAI 298
+ IP + AL+PIKD++ V+ G L +EMC K+L G+ LH YT+NLEK+ + I
Sbjct: 229 EIVIPQHFLDALDPIKDDDFLVRERGTELVSEMCNKLLQSGYVNHLHFYTMNLEKATVMI 288
Query: 299 LKNLGLIE 306
L+ L LIE
Sbjct: 289 LEKLNLIE 296
>Q0U6C4_PHANO (tr|Q0U6C4) Methylenetetrahydrofolate reductase OS=Phaeosphaeria
nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
GN=SNOG_12690 PE=3 SV=1
Length = 657
Score = 273 bits (697), Expect = 8e-71, Method: Compositional matrix adjust.
Identities = 135/315 (42%), Positives = 192/315 (60%), Gaps = 11/315 (3%)
Query: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
M + +K+ +A A K FSFEFFPPKT GV NL +RMDRM P F D+TWGAGG
Sbjct: 1 MHISQKLAQAKAE--GKPTFSFEFFPPKTAQGVQNLYDRMDRMHGFGPQFIDLTWGAGGR 58
Query: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
+ +T ++ K Q G+ET MHLTCT+M K+D+AL +G N+LALRGDPP +
Sbjct: 59 HSKLTCEMVKVAQTVYGLETCMHLTCTDMEKTKLDEALRDAYQSGCTNILALRGDPPRER 118
Query: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
+K+ GGF A+DLVK+I+ K+G++F I +AGY E D + L + +
Sbjct: 119 EKWEATAGGFRYAKDLVKYIKEKYGNHFDIGVAGYSEGSDDNDNVDEL---------IDH 169
Query: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA I+TQ+FYDTDIF+ + N R G+ I+PGIMPI+ + F+R + +
Sbjct: 170 LKEKVDAGATFIVTQMFYDTDIFIDWVNKVRAKGVDAVIIPGIMPIHTHASFLRRAQWTR 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
IP ALEPIK+++ V+ G L +MC++++ G LH YT+NL ++ +L+
Sbjct: 230 CNIPQHWTDALEPIKNDDVEVREVGKGLVADMCRRLIEAGITHLHFYTMNLAQATRMVLE 289
Query: 301 NLGLIEETSIPRTRP 315
L L+ + P +P
Sbjct: 290 ELDLLPDPGSPLEKP 304
>M3ILJ3_CANMA (tr|M3ILJ3) Methylenetetrahydrofolate reductase OS=Candida maltosa
Xu316 GN=G210_2449 PE=3 SV=1
Length = 614
Score = 273 bits (697), Expect = 9e-71, Method: Compositional matrix adjust.
Identities = 150/308 (48%), Positives = 199/308 (64%), Gaps = 14/308 (4%)
Query: 1 MKVIEKIHEA-AASDPNKVVFSFEFFPPKTEDGVVNLLERMDRMVAHSPSFCDITWGAGG 59
MK+ +K+ +A S+P FSFEFF PKT GV NL +RMDRM +P F DITW AGG
Sbjct: 1 MKISQKLSQAHNGSNPPPATFSFEFFVPKTSQGVQNLYDRMDRMYDLNPIFIDITWNAGG 60
Query: 60 STADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHG 119
++ +T ++ Q+T+G+ET MHLTCTNM VE ID+ALE +G QN+LALRGDPP
Sbjct: 61 RSSSLTNEMVYTSQSTLGLETCMHLTCTNMKVELIDEALEKAYKSGCQNILALRGDPPLD 120
Query: 120 QDKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLT 179
+ G F A+DL+++IR K+GD+F I +AGYPE HP+ ED L
Sbjct: 121 GS---ESTGDFKYAKDLIQYIRKKYGDHFNIGVAGYPEGHPEE---------EDELKTLN 168
Query: 180 YLKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK K DAGAD IITQ+FYD D F+ + + +IG+ PI+PGIMPI+ Y FIR +
Sbjct: 169 YLKEKCDAGADFIITQMFYDVDNFINWCSKLNKIGVDIPIIPGIMPISTYAAFIRRAKWS 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGF-KTLHLYTLNLEKSALAI 298
+ IP + AL+PIKD++ V+ G L +EMC K+L G+ LH YT+NLEK+ + I
Sbjct: 229 EIAIPQHFLDALDPIKDDDFLVREKGTELVSEMCTKLLQSGYINHLHFYTMNLEKATVMI 288
Query: 299 LKNLGLIE 306
L+ L LIE
Sbjct: 289 LEKLNLIE 296