Miyakogusa Predicted Gene
- Lj6g3v0657890.2
BLASTP 2.2.25 [Feb-01-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= Lj6g3v0657890.2 tr|I1LN46|I1LN46_SOYBN DNA topoisomerase
OS=Glycine max GN=Gma.49661 PE=3 SV=1,90.88,0,PRTPISMRASEI,DNA
topoisomerase, type IA; TOPOISOMERASE_I_PROK,DNA topoisomerase, type
IA, active sit,CUFF.58128.2
(669 letters)
Database: trembl
41,451,118 sequences; 13,208,986,710 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
I1LN46_SOYBN (tr|I1LN46) DNA topoisomerase OS=Glycine max PE=3 SV=1 1227 0.0
G7JBC7_MEDTR (tr|G7JBC7) DNA topoisomerase OS=Medicago truncatul... 1183 0.0
F6I488_VITVI (tr|F6I488) DNA topoisomerase OS=Vitis vinifera GN=... 1107 0.0
M5XLX9_PRUPE (tr|M5XLX9) Uncharacterized protein OS=Prunus persi... 1084 0.0
B9RRL8_RICCO (tr|B9RRL8) DNA topoisomerase OS=Ricinus communis G... 1073 0.0
B9IAB5_POPTR (tr|B9IAB5) Predicted protein OS=Populus trichocarp... 1060 0.0
M0TVE7_MUSAM (tr|M0TVE7) DNA topoisomerase OS=Musa acuminata sub... 1056 0.0
K4CWW0_SOLLC (tr|K4CWW0) DNA topoisomerase OS=Solanum lycopersic... 1022 0.0
D7LEC3_ARALL (tr|D7LEC3) DNA topoisomerase OS=Arabidopsis lyrata... 1013 0.0
M4E275_BRARP (tr|M4E275) DNA topoisomerase OS=Brassica rapa subs... 1012 0.0
F4ISQ7_ARATH (tr|F4ISQ7) DNA topoisomerase OS=Arabidopsis thalia... 1005 0.0
Q680E4_ARATH (tr|Q680E4) DNA topoisomerase OS=Arabidopsis thalia... 1003 0.0
R0FVG1_9BRAS (tr|R0FVG1) Uncharacterized protein OS=Capsella rub... 1000 0.0
Q56YZ6_ARATH (tr|Q56YZ6) DNA topoisomerase OS=Arabidopsis thalia... 996 0.0
B9G4E5_ORYSJ (tr|B9G4E5) DNA topoisomerase OS=Oryza sativa subsp... 993 0.0
Q0J0S6_ORYSJ (tr|Q0J0S6) DNA topoisomerase OS=Oryza sativa subsp... 993 0.0
I1QQ61_ORYGL (tr|I1QQ61) DNA topoisomerase OS=Oryza glaberrima P... 990 0.0
C5X4M3_SORBI (tr|C5X4M3) DNA topoisomerase OS=Sorghum bicolor GN... 989 0.0
B8BD52_ORYSI (tr|B8BD52) DNA topoisomerase OS=Oryza sativa subsp... 988 0.0
K3ZQL5_SETIT (tr|K3ZQL5) DNA topoisomerase OS=Setaria italica GN... 987 0.0
I1IRH1_BRADI (tr|I1IRH1) DNA topoisomerase OS=Brachypodium dista... 985 0.0
J3MYW0_ORYBR (tr|J3MYW0) DNA topoisomerase OS=Oryza brachyantha ... 985 0.0
M8C938_AEGTA (tr|M8C938) DNA topoisomerase 3-beta-1 OS=Aegilops ... 956 0.0
M7YPL3_TRIUA (tr|M7YPL3) DNA topoisomerase 3-beta-1 OS=Triticum ... 904 0.0
M0V3B8_HORVD (tr|M0V3B8) Uncharacterized protein OS=Hordeum vulg... 868 0.0
A9U3N3_PHYPA (tr|A9U3N3) DNA topoisomerase OS=Physcomitrella pat... 866 0.0
M0V3B7_HORVD (tr|M0V3B7) Uncharacterized protein OS=Hordeum vulg... 866 0.0
M1BDQ9_SOLTU (tr|M1BDQ9) DNA topoisomerase OS=Solanum tuberosum ... 857 0.0
Q9SKZ9_ARATH (tr|Q9SKZ9) Putative DNA topoisomerase III beta OS=... 855 0.0
D8S3T9_SELML (tr|D8S3T9) Putative uncharacterized protein OS=Sel... 830 0.0
D8R567_SELML (tr|D8R567) Putative uncharacterized protein OS=Sel... 822 0.0
A7RW77_NEMVE (tr|A7RW77) DNA topoisomerase OS=Nematostella vecte... 725 0.0
H3IS98_STRPU (tr|H3IS98) Uncharacterized protein OS=Strongylocen... 724 0.0
R7VCK8_9ANNE (tr|R7VCK8) Uncharacterized protein OS=Capitella te... 715 0.0
I0YWU4_9CHLO (tr|I0YWU4) DNA topoisomerase OS=Coccomyxa subellip... 704 0.0
F1QNX4_DANRE (tr|F1QNX4) DNA topoisomerase OS=Danio rerio GN=top... 703 0.0
M0V3B5_HORVD (tr|M0V3B5) Uncharacterized protein OS=Hordeum vulg... 703 0.0
H9G5D6_ANOCA (tr|H9G5D6) DNA topoisomerase OS=Anolis carolinensi... 701 0.0
I3JWA9_ORENI (tr|I3JWA9) DNA topoisomerase OS=Oreochromis niloti... 701 0.0
E1ZIK6_CHLVA (tr|E1ZIK6) DNA topoisomerase OS=Chlorella variabil... 700 0.0
G3HFY0_CRIGR (tr|G3HFY0) DNA topoisomerase OS=Cricetulus griseus... 697 0.0
G5BKF9_HETGA (tr|G5BKF9) DNA topoisomerase OS=Heterocephalus gla... 697 0.0
H0UX40_CAVPO (tr|H0UX40) DNA topoisomerase OS=Cavia porcellus GN... 697 0.0
R7VUT8_COLLI (tr|R7VUT8) DNA topoisomerase 3-beta-1 OS=Columba l... 695 0.0
Q5ZK71_CHICK (tr|Q5ZK71) DNA topoisomerase OS=Gallus gallus GN=T... 694 0.0
Q3UJF5_MOUSE (tr|Q3UJF5) DNA topoisomerase OS=Mus musculus GN=To... 694 0.0
I3NC26_SPETR (tr|I3NC26) DNA topoisomerase OS=Spermophilus tride... 694 0.0
C3Z1Q7_BRAFL (tr|C3Z1Q7) DNA topoisomerase OS=Branchiostoma flor... 693 0.0
G3NI54_GASAC (tr|G3NI54) DNA topoisomerase (Fragment) OS=Gastero... 693 0.0
G3TL95_LOXAF (tr|G3TL95) DNA topoisomerase OS=Loxodonta africana... 692 0.0
G3W4B1_SARHA (tr|G3W4B1) DNA topoisomerase OS=Sarcophilus harris... 692 0.0
K1Q3B4_CRAGI (tr|K1Q3B4) DNA topoisomerase 3-beta-1 OS=Crassostr... 692 0.0
Q7ZWP8_XENLA (tr|Q7ZWP8) DNA topoisomerase OS=Xenopus laevis GN=... 692 0.0
F1RL05_PIG (tr|F1RL05) DNA topoisomerase OS=Sus scrofa GN=TOP3B ... 692 0.0
F7ADD1_CALJA (tr|F7ADD1) DNA topoisomerase OS=Callithrix jacchus... 691 0.0
D4A9Z2_RAT (tr|D4A9Z2) DNA topoisomerase OS=Rattus norvegicus GN... 691 0.0
Q7ZY67_XENLA (tr|Q7ZY67) DNA topoisomerase (Fragment) OS=Xenopus... 691 0.0
F7FUS9_MONDO (tr|F7FUS9) DNA topoisomerase OS=Monodelphis domest... 690 0.0
F6X812_XENTR (tr|F6X812) DNA topoisomerase OS=Xenopus tropicalis... 689 0.0
G1MQQ8_MELGA (tr|G1MQQ8) DNA topoisomerase OS=Meleagris gallopav... 689 0.0
F6WCJ0_HORSE (tr|F6WCJ0) DNA topoisomerase OS=Equus caballus GN=... 689 0.0
L5LIY6_MYODS (tr|L5LIY6) DNA topoisomerase OS=Myotis davidii GN=... 689 0.0
H0ZEB7_TAEGU (tr|H0ZEB7) DNA topoisomerase (Fragment) OS=Taeniop... 688 0.0
R0L3G6_ANAPL (tr|R0L3G6) DNA topoisomerase 3-beta-1 (Fragment) O... 687 0.0
H0XH52_OTOGA (tr|H0XH52) DNA topoisomerase OS=Otolemur garnettii... 687 0.0
M3VYV1_FELCA (tr|M3VYV1) DNA topoisomerase OS=Felis catus GN=TOP... 687 0.0
G1T303_RABIT (tr|G1T303) DNA topoisomerase OS=Oryctolagus cunicu... 686 0.0
K9IP36_DESRO (tr|K9IP36) DNA topoisomerase OS=Desmodus rotundus ... 686 0.0
H2R4A2_PANTR (tr|H2R4A2) DNA topoisomerase OS=Pan troglodytes GN... 686 0.0
E2R770_CANFA (tr|E2R770) DNA topoisomerase OS=Canis familiaris G... 686 0.0
G1PFL3_MYOLU (tr|G1PFL3) DNA topoisomerase OS=Myotis lucifugus P... 686 0.0
H2P4Z3_PONAB (tr|H2P4Z3) DNA topoisomerase OS=Pongo abelii GN=TO... 685 0.0
G1LLS2_AILME (tr|G1LLS2) DNA topoisomerase OS=Ailuropoda melanol... 685 0.0
F7ES60_XENTR (tr|F7ES60) DNA topoisomerase OS=Xenopus tropicalis... 685 0.0
M3ZQ84_XIPMA (tr|M3ZQ84) DNA topoisomerase OS=Xiphophorus macula... 684 0.0
G7PHB7_MACFA (tr|G7PHB7) DNA topoisomerase OS=Macaca fasciculari... 684 0.0
F7GH88_MACMU (tr|F7GH88) DNA topoisomerase OS=Macaca mulatta GN=... 684 0.0
D2I7M2_AILME (tr|D2I7M2) DNA topoisomerase (Fragment) OS=Ailurop... 684 0.0
H9EST7_MACMU (tr|H9EST7) DNA topoisomerase OS=Macaca mulatta GN=... 683 0.0
G8F1W3_MACMU (tr|G8F1W3) DNA topoisomerase OS=Macaca mulatta GN=... 683 0.0
C0H9Z6_SALSA (tr|C0H9Z6) DNA topoisomerase OS=Salmo salar GN=TOP... 683 0.0
G9KUN5_MUSPF (tr|G9KUN5) DNA topoisomerase (Fragment) OS=Mustela... 682 0.0
M3XVK3_MUSPF (tr|M3XVK3) DNA topoisomerase OS=Mustela putorius f... 682 0.0
A8K4N2_HUMAN (tr|A8K4N2) DNA topoisomerase OS=Homo sapiens PE=2 ... 681 0.0
G1TFH8_RABIT (tr|G1TFH8) DNA topoisomerase OS=Oryctolagus cunicu... 681 0.0
F6ST44_CIOIN (tr|F6ST44) DNA topoisomerase (Fragment) OS=Ciona i... 680 0.0
H9K0I5_APIME (tr|H9K0I5) DNA topoisomerase OS=Apis mellifera GN=... 677 0.0
L8HVJ0_BOSMU (tr|L8HVJ0) DNA topoisomerase (Fragment) OS=Bos gru... 677 0.0
G3W4B0_SARHA (tr|G3W4B0) DNA topoisomerase (Fragment) OS=Sarcoph... 667 0.0
L9LCG8_TUPCH (tr|L9LCG8) DNA topoisomerase OS=Tupaia chinensis G... 665 0.0
K7J2S1_NASVI (tr|K7J2S1) DNA topoisomerase OS=Nasonia vitripenni... 665 0.0
E0VDP5_PEDHC (tr|E0VDP5) DNA topoisomerase OS=Pediculus humanus ... 662 0.0
E2A762_CAMFO (tr|E2A762) DNA topoisomerase OS=Camponotus florida... 661 0.0
E2BPS8_HARSA (tr|E2BPS8) DNA topoisomerase OS=Harpegnathos salta... 656 0.0
D2A047_TRICA (tr|D2A047) DNA topoisomerase OS=Tribolium castaneu... 656 0.0
F4WE22_ACREC (tr|F4WE22) DNA topoisomerase OS=Acromyrmex echinat... 654 0.0
G6DFU9_DANPL (tr|G6DFU9) DNA topoisomerase OS=Danaus plexippus G... 653 0.0
K7GCG7_PELSI (tr|K7GCG7) DNA topoisomerase OS=Pelodiscus sinensi... 648 0.0
K3WPG6_PYTUL (tr|K3WPG6) DNA topoisomerase OS=Pythium ultimum GN... 645 0.0
F2UL82_SALS5 (tr|F2UL82) DNA topoisomerase OS=Salpingoeca sp. (s... 637 e-180
D8TJM6_VOLCA (tr|D8TJM6) DNA topoisomerase OS=Volvox carteri GN=... 636 e-179
B7Q7K8_IXOSC (tr|B7Q7K8) Topoisomerase I, putative OS=Ixodes sca... 630 e-178
L5KVZ8_PTEAL (tr|L5KVZ8) DNA topoisomerase OS=Pteropus alecto GN... 626 e-176
B6KLI4_TOXGO (tr|B6KLI4) DNA topoisomerase OS=Toxoplasma gondii ... 625 e-176
B9QEY2_TOXGO (tr|B9QEY2) DNA topoisomerase OS=Toxoplasma gondii ... 620 e-175
B3RKZ5_TRIAD (tr|B3RKZ5) Putative uncharacterized protein OS=Tri... 618 e-174
M7BQV0_CHEMY (tr|M7BQV0) DNA topoisomerase 3-beta-1 OS=Chelonia ... 618 e-174
H3B0D1_LATCH (tr|H3B0D1) DNA topoisomerase OS=Latimeria chalumna... 617 e-174
B0WQT7_CULQU (tr|B0WQT7) DNA topoisomerase OS=Culex quinquefasci... 617 e-174
Q16PL8_AEDAE (tr|Q16PL8) DNA topoisomerase OS=Aedes aegypti GN=A... 616 e-174
K8YSM6_9STRA (tr|K8YSM6) DNA topoisomerase OS=Nannochloropsis ga... 613 e-173
B4L687_DROMO (tr|B4L687) DNA topoisomerase OS=Drosophila mojaven... 609 e-171
Q29HK8_DROPS (tr|Q29HK8) DNA topoisomerase OS=Drosophila pseudoo... 609 e-171
B4GXI4_DROPE (tr|B4GXI4) DNA topoisomerase OS=Drosophila persimi... 609 e-171
B4NCN9_DROWI (tr|B4NCN9) DNA topoisomerase OS=Drosophila willist... 609 e-171
J9K7K9_ACYPI (tr|J9K7K9) Uncharacterized protein OS=Acyrthosipho... 609 e-171
A9V3W6_MONBE (tr|A9V3W6) DNA topoisomerase OS=Monosiga brevicoll... 608 e-171
B4JK56_DROGR (tr|B4JK56) DNA topoisomerase OS=Drosophila grimsha... 607 e-171
B4MAH9_DROVI (tr|B4MAH9) DNA topoisomerase OS=Drosophila virilis... 604 e-170
C1DYX0_MICSR (tr|C1DYX0) Predicted protein OS=Micromonas sp. (st... 603 e-169
B3MQ67_DROAN (tr|B3MQ67) DNA topoisomerase OS=Drosophila ananass... 599 e-168
F1KW18_ASCSU (tr|F1KW18) DNA topoisomerase OS=Ascaris suum PE=2 ... 598 e-168
B4I0C6_DROSE (tr|B4I0C6) DNA topoisomerase OS=Drosophila sechell... 598 e-168
B4PYQ9_DROYA (tr|B4PYQ9) DNA topoisomerase OS=Drosophila yakuba ... 597 e-168
B4R5E8_DROSI (tr|B4R5E8) DNA topoisomerase OS=Drosophila simulan... 597 e-168
B3NXQ6_DROER (tr|B3NXQ6) DNA topoisomerase OS=Drosophila erecta ... 596 e-168
Q384B1_TRYB2 (tr|Q384B1) DNA topoisomerase III, putative OS=Tryp... 594 e-167
D0A8A5_TRYB9 (tr|D0A8A5) DNA topoisomerase III, putative OS=Tryp... 594 e-167
A4URT2_TRYBB (tr|A4URT2) Topoisomerase IIIbeta OS=Trypanosoma br... 594 e-167
K2NGF1_TRYCR (tr|K2NGF1) DNA topoisomerase III, putative OS=Tryp... 594 e-167
K4E7B0_TRYCR (tr|K4E7B0) DNA topoisomerase III, putative OS=Tryp... 592 e-166
F6SDD7_MOUSE (tr|F6SDD7) DNA topoisomerase (Fragment) OS=Mus mus... 591 e-166
Q4DXC5_TRYCC (tr|Q4DXC5) DNA topoisomerase III, putative OS=Tryp... 590 e-166
C5KCJ6_PERM5 (tr|C5KCJ6) DNA topoisomerase OS=Perkinsus marinus ... 589 e-165
F0WSH2_9STRA (tr|F0WSH2) DNA topoisomerase OS=Albugo laibachii N... 588 e-165
F6QNQ6_MACMU (tr|F6QNQ6) DNA topoisomerase OS=Macaca mulatta GN=... 585 e-164
E9BJR1_LEIDB (tr|E9BJR1) DNA topoisomerase III, putative OS=Leis... 585 e-164
H0Y6W0_HUMAN (tr|H0Y6W0) DNA topoisomerase (Fragment) OS=Homo sa... 584 e-164
A4I3Q5_LEIIN (tr|A4I3Q5) Putative DNA topoisomerase III OS=Leish... 584 e-164
A4HGN1_LEIBR (tr|A4HGN1) Putative DNA topoisomerase III OS=Leish... 584 e-164
G0V1G7_TRYCI (tr|G0V1G7) Putative uncharacterized protein TCIL30... 583 e-164
D0EG00_LEIDO (tr|D0EG00) DNA topoisomerase III beta OS=Leishmani... 579 e-162
G4VFA7_SCHMA (tr|G4VFA7) Putative prokaryotic DNA topoisomerase ... 578 e-162
E9AZZ7_LEIMU (tr|E9AZZ7) Putative DNA topoisomerase III OS=Leish... 578 e-162
I1BYY5_RHIO9 (tr|I1BYY5) DNA topoisomerase OS=Rhizopus delemar (... 576 e-161
Q4Q888_LEIMA (tr|Q4Q888) Putative DNA topoisomerase III OS=Leish... 575 e-161
C1N1P2_MICPC (tr|C1N1P2) Predicted protein OS=Micromonas pusilla... 571 e-160
G0PNJ8_CAEBE (tr|G0PNJ8) DNA topoisomerase (Fragment) OS=Caenorh... 571 e-160
F0VBK1_NEOCL (tr|F0VBK1) DNA topoisomerase OS=Neospora caninum (... 568 e-159
H1UBJ6_CAEEL (tr|H1UBJ6) DNA topoisomerase OS=Caenorhabditis ele... 568 e-159
H1UBJ9_CAEEL (tr|H1UBJ9) DNA topoisomerase OS=Caenorhabditis ele... 567 e-159
E3MMT0_CAERE (tr|E3MMT0) DNA topoisomerase OS=Caenorhabditis rem... 567 e-159
E4X5F4_OIKDI (tr|E4X5F4) DNA topoisomerase OS=Oikopleura dioica ... 562 e-157
E4Y9R3_OIKDI (tr|E4Y9R3) DNA topoisomerase OS=Oikopleura dioica ... 561 e-157
E4Y9S6_OIKDI (tr|E4Y9S6) DNA topoisomerase OS=Oikopleura dioica ... 560 e-156
H2MSA1_ORYLA (tr|H2MSA1) DNA topoisomerase OS=Oryzias latipes PE... 559 e-156
A8PGM1_BRUMA (tr|A8PGM1) DNA topoisomerase OS=Brugia malayi GN=B... 553 e-155
D8LYS1_BLAHO (tr|D8LYS1) DNA topoisomerase OS=Blastocystis homin... 552 e-154
E1G0B3_LOALO (tr|E1G0B3) DNA topoisomerase OS=Loa loa GN=LOAG_06... 550 e-154
G0UCD3_TRYVY (tr|G0UCD3) Putative DNA topoisomerase III OS=Trypa... 549 e-153
A8J6M3_CHLRE (tr|A8J6M3) DNA topoisomerase (Fragment) OS=Chlamyd... 544 e-152
H9JJ16_BOMMO (tr|H9JJ16) Uncharacterized protein OS=Bombyx mori ... 527 e-147
H2SPY9_TAKRU (tr|H2SPY9) Uncharacterized protein OS=Takifugu rub... 521 e-145
H3CHY5_TETNG (tr|H3CHY5) Uncharacterized protein OS=Tetraodon ni... 519 e-144
Q4T0Q4_TETNG (tr|Q4T0Q4) Chromosome undetermined SCAF10893, whol... 517 e-144
A4RZ61_OSTLU (tr|A4RZ61) DNA topoisomerase OS=Ostreococcus lucim... 517 e-144
G0MZ90_CAEBE (tr|G0MZ90) DNA topoisomerase OS=Caenorhabditis bre... 513 e-142
B6ADG7_CRYMR (tr|B6ADG7) DNA topoisomerase OS=Cryptosporidium mu... 505 e-140
E5SGB5_TRISP (tr|E5SGB5) DNA topoisomerase OS=Trichinella spiral... 498 e-138
L1JH36_GUITH (tr|L1JH36) DNA topoisomerase OS=Guillardia theta C... 497 e-138
Q7YYF5_CRYPV (tr|Q7YYF5) DNA topoisomerase OS=Cryptosporidium pa... 492 e-136
A3FPU5_CRYPI (tr|A3FPU5) DNA topoisomerase OS=Cryptosporidium pa... 492 e-136
H2YRK6_CIOSA (tr|H2YRK6) Uncharacterized protein (Fragment) OS=C... 490 e-136
H9KK00_APIME (tr|H9KK00) Uncharacterized protein (Fragment) OS=A... 488 e-135
H3G0S1_PRIPA (tr|H3G0S1) DNA topoisomerase OS=Pristionchus pacif... 487 e-135
C5LF56_PERM5 (tr|C5LF56) DNA topoisomerase OS=Perkinsus marinus ... 484 e-134
G1QHD0_NOMLE (tr|G1QHD0) DNA topoisomerase OS=Nomascus leucogeny... 481 e-133
B7FQA8_PHATC (tr|B7FQA8) DNA topoisomerase (Fragment) OS=Phaeoda... 474 e-131
A7AST5_BABBO (tr|A7AST5) DNA topoisomerase OS=Babesia bovis GN=B... 466 e-128
H9IIY3_ATTCE (tr|H9IIY3) DNA topoisomerase OS=Atta cephalotes PE... 457 e-126
M0V3B6_HORVD (tr|M0V3B6) Uncharacterized protein OS=Hordeum vulg... 444 e-122
E3X5N1_ANODA (tr|E3X5N1) Uncharacterized protein OS=Anopheles da... 441 e-121
M1BDR0_SOLTU (tr|M1BDR0) Uncharacterized protein OS=Solanum tube... 436 e-119
I1G5R1_AMPQE (tr|I1G5R1) DNA topoisomerase OS=Amphimedon queensl... 434 e-119
I7M423_TETTS (tr|I7M423) DNA topoisomerase OS=Tetrahymena thermo... 429 e-117
G7YI59_CLOSI (tr|G7YI59) DNA topoisomerase III OS=Clonorchis sin... 429 e-117
H2YRK7_CIOSA (tr|H2YRK7) DNA topoisomerase OS=Ciona savignyi PE=... 411 e-112
Q4R3L0_MACFA (tr|Q4R3L0) Testis cDNA clone: QtsA-16130, similar ... 405 e-110
A0DGW1_PARTE (tr|A0DGW1) DNA topoisomerase OS=Paramecium tetraur... 403 e-109
Q24DD8_TETTS (tr|Q24DD8) DNA topoisomerase OS=Tetrahymena thermo... 399 e-108
I7IPQ5_BABMI (tr|I7IPQ5) DNA topoisomerase OS=Babesia microti st... 390 e-105
E3CU83_CAEBR (tr|E3CU83) DNA topoisomerase (Fragment) OS=Caenorh... 387 e-105
Q95R42_DROME (tr|Q95R42) SD10251p OS=Drosophila melanogaster GN=... 384 e-104
E5T3E6_TRISP (tr|E5T3E6) DNA topoisomerase domain protein (Fragm... 382 e-103
H3G0S0_PRIPA (tr|H3G0S0) DNA topoisomerase OS=Pristionchus pacif... 379 e-102
K8F5K0_9CHLO (tr|K8F5K0) DNA topoisomerase OS=Bathycoccus prasin... 378 e-102
J9FCG0_9SPIT (tr|J9FCG0) DNA topoisomerase OS=Oxytricha trifalla... 374 e-101
H2YRK8_CIOSA (tr|H2YRK8) DNA topoisomerase OS=Ciona savignyi PE=... 374 e-100
M2Y2M1_GALSU (tr|M2Y2M1) DNA topoisomerase OS=Galdieria sulphura... 365 4e-98
F0X3Y0_CRYPV (tr|F0X3Y0) Cgd6_2390 protein OS=Cryptosporidium pa... 358 4e-96
Q5CNC8_CRYHO (tr|Q5CNC8) DNA topoisomerase III beta-1 OS=Cryptos... 358 5e-96
G0QK41_ICHMG (tr|G0QK41) DNA topoisomerase (Fragment) OS=Ichthyo... 358 5e-96
B8CGH9_THAPS (tr|B8CGH9) DNA topoisomerase OS=Thalassiosira pseu... 344 6e-92
J9E791_WUCBA (tr|J9E791) DNA topoisomerase OS=Wuchereria bancrof... 343 1e-91
I7M4N6_TETTS (tr|I7M4N6) DNA topoisomerase OS=Tetrahymena thermo... 337 9e-90
N9UWP2_ENTHI (tr|N9UWP2) DNA topoisomerase 3-beta-1, putative OS... 335 3e-89
M7X9I8_ENTHI (tr|M7X9I8) DNA topoisomerase 3-beta-1, putative OS... 335 3e-89
M3TTG7_ENTHI (tr|M3TTG7) DNA topoisomerase OS=Entamoeba histolyt... 335 3e-89
M2RCU9_ENTHI (tr|M2RCU9) DNA topoisomerase OS=Entamoeba histolyt... 335 3e-89
C4M656_ENTHI (tr|C4M656) DNA topoisomerase OS=Entamoeba histolyt... 335 3e-89
A8B577_GIAIC (tr|A8B577) DNA topoisomerase III OS=Giardia intest... 334 5e-89
R1ENA1_EMIHU (tr|R1ENA1) Uncharacterized protein OS=Emiliania hu... 334 7e-89
K2G4I6_ENTNP (tr|K2G4I6) DNA topoisomerase OS=Entamoeba nuttalli... 333 2e-88
E1F9F6_GIAIA (tr|E1F9F6) DNA topoisomerase III OS=Giardia intest... 328 5e-87
B0ERJ9_ENTDS (tr|B0ERJ9) DNA topoisomerase OS=Entamoeba dispar (... 328 5e-87
C0PCH2_MAIZE (tr|C0PCH2) Uncharacterized protein OS=Zea mays PE=... 323 2e-85
D2VSX3_NAEGR (tr|D2VSX3) Predicted protein OS=Naegleria gruberi ... 317 1e-83
I7LXJ3_TETTS (tr|I7LXJ3) DNA topoisomerase OS=Tetrahymena thermo... 316 3e-83
F0XY93_AURAN (tr|F0XY93) DNA topoisomerase (Fragment) OS=Aureoco... 315 5e-83
I7LVW6_TETTS (tr|I7LVW6) DNA topoisomerase OS=Tetrahymena thermo... 312 3e-82
D7FUP7_ECTSI (tr|D7FUP7) DNA topoisomerase OS=Ectocarpus silicul... 312 3e-82
M5XGT8_PRUPE (tr|M5XGT8) Uncharacterized protein OS=Prunus persi... 310 2e-81
B3KU89_HUMAN (tr|B3KU89) cDNA FLJ39376 fis, clone PERIC1000025, ... 309 3e-81
D3BRX9_POLPA (tr|D3BRX9) Ribose-phosphate pyrophosphokinase OS=P... 305 3e-80
F4PXY0_DICFS (tr|F4PXY0) DNA topoisomerase III OS=Dictyostelium ... 302 3e-79
B1H2R2_XENTR (tr|B1H2R2) DNA topoisomerase OS=Xenopus tropicalis... 299 2e-78
H1UBJ8_CAEEL (tr|H1UBJ8) Protein Y48C3A.14, isoform b OS=Caenorh... 295 4e-77
F7C5J9_XENTR (tr|F7C5J9) DNA topoisomerase OS=Xenopus tropicalis... 295 4e-77
F0ZSL6_DICPU (tr|F0ZSL6) Putative uncharacterized protein OS=Dic... 291 7e-76
A9YJ49_DROME (tr|A9YJ49) Topoisomerase 3 beta (Fragment) OS=Dros... 282 3e-73
A9YJ44_DROME (tr|A9YJ44) CG3458 (Fragment) OS=Drosophila melanog... 282 3e-73
L8YCR4_TUPCH (tr|L8YCR4) DNA topoisomerase OS=Tupaia chinensis G... 282 4e-73
Q4W5X0_CHICK (tr|Q4W5X0) DNA topoisomerase OS=Gallus gallus GN=T... 281 5e-73
F1P1F3_CHICK (tr|F1P1F3) DNA topoisomerase OS=Gallus gallus GN=T... 281 5e-73
H9GF12_ANOCA (tr|H9GF12) DNA topoisomerase OS=Anolis carolinensi... 281 7e-73
K7GGN4_PELSI (tr|K7GGN4) DNA topoisomerase OS=Pelodiscus sinensi... 280 1e-72
K7GGM4_PELSI (tr|K7GGM4) DNA topoisomerase OS=Pelodiscus sinensi... 280 1e-72
Q6GPC0_XENLA (tr|Q6GPC0) DNA topoisomerase OS=Xenopus laevis GN=... 278 5e-72
G3SN49_LOXAF (tr|G3SN49) DNA topoisomerase OS=Loxodonta africana... 278 6e-72
I3MP50_SPETR (tr|I3MP50) DNA topoisomerase OS=Spermophilus tride... 278 7e-72
E2RIS5_CANFA (tr|E2RIS5) DNA topoisomerase OS=Canis familiaris G... 277 1e-71
G1SQY7_RABIT (tr|G1SQY7) DNA topoisomerase OS=Oryctolagus cunicu... 276 2e-71
L5KY49_PTEAL (tr|L5KY49) DNA topoisomerase OS=Pteropus alecto GN... 276 2e-71
F7A1S4_XENTR (tr|F7A1S4) DNA topoisomerase (Fragment) OS=Xenopus... 276 2e-71
I3JP29_ORENI (tr|I3JP29) DNA topoisomerase OS=Oreochromis niloti... 276 2e-71
H3AKB8_LATCH (tr|H3AKB8) DNA topoisomerase OS=Latimeria chalumna... 276 3e-71
I3JP28_ORENI (tr|I3JP28) DNA topoisomerase (Fragment) OS=Oreochr... 276 3e-71
L8J1J2_BOSMU (tr|L8J1J2) DNA topoisomerase OS=Bos grunniens mutu... 275 3e-71
F1MGY1_BOVIN (tr|F1MGY1) DNA topoisomerase OS=Bos taurus GN=TOP3... 275 5e-71
A0JN73_BOVIN (tr|A0JN73) DNA topoisomerase OS=Bos taurus GN=TOP3... 275 5e-71
K9INH6_DESRO (tr|K9INH6) DNA topoisomerase OS=Desmodus rotundus ... 274 8e-71
H0VEI8_CAVPO (tr|H0VEI8) DNA topoisomerase OS=Cavia porcellus GN... 274 1e-70
G5BMX8_HETGA (tr|G5BMX8) DNA topoisomerase OS=Heterocephalus gla... 274 1e-70
G1NSV2_MYOLU (tr|G1NSV2) DNA topoisomerase OS=Myotis lucifugus P... 273 1e-70
M3XLT6_MUSPF (tr|M3XLT6) DNA topoisomerase OS=Mustela putorius f... 273 1e-70
K9J3S6_DESRO (tr|K9J3S6) DNA topoisomerase (Fragment) OS=Desmodu... 273 1e-70
Q5NCT0_MOUSE (tr|Q5NCT0) DNA topoisomerase 3-alpha OS=Mus muscul... 273 1e-70
B0QZI1_MOUSE (tr|B0QZI1) DNA topoisomerase 3-alpha OS=Mus muscul... 273 2e-70
Q3TPE4_MOUSE (tr|Q3TPE4) Putative uncharacterized protein OS=Mus... 273 2e-70
Q8CDI8_MOUSE (tr|Q8CDI8) DNA topoisomerase (Fragment) OS=Mus mus... 273 2e-70
Q5NCT2_MOUSE (tr|Q5NCT2) Topoisomerase (DNA) III alpha OS=Mus mu... 273 2e-70
M3WMK3_FELCA (tr|M3WMK3) DNA topoisomerase OS=Felis catus GN=TOP... 272 3e-70
Q3V3P1_MOUSE (tr|Q3V3P1) DNA topoisomerase OS=Mus musculus GN=To... 272 3e-70
F6QP60_MONDO (tr|F6QP60) DNA topoisomerase OS=Monodelphis domest... 272 3e-70
H6BXA1_EXODN (tr|H6BXA1) DNA topoisomerase OS=Exophiala dermatit... 272 3e-70
H9EWR7_MACMU (tr|H9EWR7) DNA topoisomerase OS=Macaca mulatta GN=... 272 4e-70
H9Z0Q7_MACMU (tr|H9Z0Q7) DNA topoisomerase OS=Macaca mulatta GN=... 272 4e-70
Q3TBE3_MOUSE (tr|Q3TBE3) DNA topoisomerase OS=Mus musculus GN=To... 271 5e-70
H2MFK0_ORYLA (tr|H2MFK0) DNA topoisomerase (Fragment) OS=Oryzias... 271 5e-70
G1LDT8_AILME (tr|G1LDT8) DNA topoisomerase OS=Ailuropoda melanol... 271 6e-70
G7PTT8_MACFA (tr|G7PTT8) DNA topoisomerase (Fragment) OS=Macaca ... 271 7e-70
Q9JJ62_MOUSE (tr|Q9JJ62) DNA topoisomerase OS=Mus musculus GN=To... 271 7e-70
B4DK80_HUMAN (tr|B4DK80) DNA topoisomerase OS=Homo sapiens GN=TO... 271 7e-70
G1N063_MELGA (tr|G1N063) DNA topoisomerase OS=Meleagris gallopav... 271 8e-70
R0JZT4_ANAPL (tr|R0JZT4) DNA topoisomerase 3-alpha (Fragment) OS... 271 8e-70
H2R419_PANTR (tr|H2R419) DNA topoisomerase OS=Pan troglodytes GN... 271 9e-70
M2RFS6_CERSU (tr|M2RFS6) DNA topoisomerase OS=Ceriporiopsis subv... 270 1e-69
F8PV61_SERL3 (tr|F8PV61) DNA topoisomerase OS=Serpula lacrymans ... 270 1e-69
E7EWY2_HUMAN (tr|E7EWY2) DNA topoisomerase OS=Homo sapiens GN=TO... 270 1e-69
F6YMD1_HORSE (tr|F6YMD1) DNA topoisomerase (Fragment) OS=Equus c... 270 1e-69
M3ZNA2_XIPMA (tr|M3ZNA2) DNA topoisomerase OS=Xiphophorus macula... 270 2e-69
E2BS26_HARSA (tr|E2BS26) DNA topoisomerase OS=Harpegnathos salta... 270 2e-69
G7NJ30_MACMU (tr|G7NJ30) DNA topoisomerase OS=Macaca mulatta GN=... 270 2e-69
N9V6M2_ENTHI (tr|N9V6M2) DNA topoisomerase 3-alpha, putative OS=... 270 2e-69
M7X249_ENTHI (tr|M7X249) DNA topoisomerase 3-alpha, putative OS=... 270 2e-69
M3TZI6_ENTHI (tr|M3TZI6) DNA topoisomerase domain containing pro... 270 2e-69
M2RJ45_ENTHI (tr|M2RJ45) DNA topoisomerase alpha, putative OS=En... 270 2e-69
C4LZR4_ENTHI (tr|C4LZR4) DNA topoisomerase III, putative OS=Enta... 270 2e-69
R7Q6W3_CHOCR (tr|R7Q6W3) Stackhouse genomic scaffold, scaffold_1... 269 3e-69
G3NY56_GASAC (tr|G3NY56) DNA topoisomerase (Fragment) OS=Gastero... 269 3e-69
B4E3G2_HUMAN (tr|B4E3G2) DNA topoisomerase OS=Homo sapiens PE=2 ... 269 3e-69
K2HPK8_ENTNP (tr|K2HPK8) DNA topoisomerase domain containing pro... 269 4e-69
G1RUU7_NOMLE (tr|G1RUU7) DNA topoisomerase OS=Nomascus leucogeny... 268 4e-69
H2NSY8_PONAB (tr|H2NSY8) DNA topoisomerase (Fragment) OS=Pongo a... 268 4e-69
G3NY50_GASAC (tr|G3NY50) DNA topoisomerase (Fragment) OS=Gastero... 268 4e-69
B0EMC7_ENTDS (tr|B0EMC7) DNA topoisomerase 3-alpha, putative OS=... 268 5e-69
A7AMD4_BABBO (tr|A7AMD4) DNA topoisomerase family protein OS=Bab... 268 7e-69
G3GVI0_CRIGR (tr|G3GVI0) DNA topoisomerase OS=Cricetulus griseus... 268 8e-69
A0CUH3_PARTE (tr|A0CUH3) Chromosome undetermined scaffold_28, wh... 267 8e-69
H0Z9W6_TAEGU (tr|H0Z9W6) DNA topoisomerase (Fragment) OS=Taeniop... 267 9e-69
B9PMP6_TOXGO (tr|B9PMP6) DNA topoisomerase OS=Toxoplasma gondii ... 267 1e-68
B6KEM8_TOXGO (tr|B6KEM8) DNA topoisomerase OS=Toxoplasma gondii ... 267 1e-68
A8XHL1_CAEBR (tr|A8XHL1) DNA topoisomerase OS=Caenorhabditis bri... 266 2e-68
K5WXT1_AGABU (tr|K5WXT1) DNA topoisomerase OS=Agaricus bisporus ... 266 2e-68
F1R242_DANRE (tr|F1R242) DNA topoisomerase (Fragment) OS=Danio r... 265 3e-68
A0DS57_PARTE (tr|A0DS57) Chromosome undetermined scaffold_61, wh... 265 3e-68
K0TAA4_THAOC (tr|K0TAA4) Uncharacterized protein (Fragment) OS=T... 265 3e-68
F0WXP0_9STRA (tr|F0WXP0) DNA topoisomerase putative OS=Albugo la... 264 7e-68
K9HST2_AGABB (tr|K9HST2) DNA topoisomerase OS=Agaricus bisporus ... 264 7e-68
F6Z0N0_ORNAN (tr|F6Z0N0) DNA topoisomerase (Fragment) OS=Ornitho... 264 8e-68
F0WXN4_9STRA (tr|F0WXN4) DNA topoisomerase putative OS=Albugo la... 264 8e-68
F0WXN7_9STRA (tr|F0WXN7) DNA topoisomerase putative OS=Albugo la... 264 8e-68
F0WXN8_9STRA (tr|F0WXN8) DNA topoisomerase putative OS=Albugo la... 264 8e-68
F0WXN1_9STRA (tr|F0WXN1) DNA topoisomerase putative OS=Albugo la... 264 9e-68
F0WXN6_9STRA (tr|F0WXN6) DNA topoisomerase putative OS=Albugo la... 264 1e-67
L7LY29_9ACAR (tr|L7LY29) DNA topoisomerase OS=Rhipicephalus pulc... 263 1e-67
Q2UEI0_ASPOR (tr|Q2UEI0) DNA topoisomerase OS=Aspergillus oryzae... 263 1e-67
I8A9T8_ASPO3 (tr|I8A9T8) DNA topoisomerase OS=Aspergillus oryzae... 263 1e-67
B8NFR2_ASPFN (tr|B8NFR2) DNA topoisomerase OS=Aspergillus flavus... 263 1e-67
H2SSS8_TAKRU (tr|H2SSS8) DNA topoisomerase (Fragment) OS=Takifug... 263 1e-67
R9AS06_WALIC (tr|R9AS06) DNA topoisomerase 3 OS=Wallemia ichthyo... 263 2e-67
A1CF66_ASPCL (tr|A1CF66) DNA topoisomerase OS=Aspergillus clavat... 263 2e-67
H0X7X3_OTOGA (tr|H0X7X3) DNA topoisomerase OS=Otolemur garnettii... 263 2e-67
R7TJU1_9ANNE (tr|R7TJU1) Uncharacterized protein OS=Capitella te... 263 3e-67
M5G9P4_DACSP (tr|M5G9P4) Prokaryotic type I DNA topoisomerase OS... 263 3e-67
G3VJM6_SARHA (tr|G3VJM6) DNA topoisomerase OS=Sarcophilus harris... 262 3e-67
H9K4U5_APIME (tr|H9K4U5) DNA topoisomerase OS=Apis mellifera GN=... 261 6e-67
G0NRK3_CAEBE (tr|G0NRK3) DNA topoisomerase OS=Caenorhabditis bre... 261 7e-67
A4IDA8_LEIIN (tr|A4IDA8) DNA topoisomerase OS=Leishmania infantu... 261 8e-67
G4VM01_SCHMA (tr|G4VM01) Putative prokaryotic DNA topoisomerase ... 261 9e-67
H9HDQ6_ATTCE (tr|H9HDQ6) DNA topoisomerase OS=Atta cephalotes PE... 261 9e-67
E9BU44_LEIDB (tr|E9BU44) DNA topoisomerase OS=Leishmania donovan... 260 1e-66
F0WXN2_9STRA (tr|F0WXN2) DNA topoisomerase putative OS=Albugo la... 260 1e-66
H2WE23_CAEJA (tr|H2WE23) DNA topoisomerase OS=Caenorhabditis jap... 260 1e-66
H3IXZ3_STRPU (tr|H3IXZ3) Uncharacterized protein OS=Strongylocen... 260 1e-66
F0WXN3_9STRA (tr|F0WXN3) DNA topoisomerase putative OS=Albugo la... 260 2e-66
F0WXN9_9STRA (tr|F0WXN9) DNA topoisomerase putative OS=Albugo la... 260 2e-66
F0WXN5_9STRA (tr|F0WXN5) DNA topoisomerase putative OS=Albugo la... 260 2e-66
B7G3B1_PHATC (tr|B7G3B1) DNA topoisomerase OS=Phaeodactylum tric... 259 2e-66
F4X1K5_ACREC (tr|F4X1K5) DNA topoisomerase OS=Acromyrmex echinat... 259 2e-66
B3RSB2_TRIAD (tr|B3RSB2) Putative uncharacterized protein OS=Tri... 259 3e-66
K9G3X9_PEND1 (tr|K9G3X9) DNA topoisomerase OS=Penicillium digita... 259 3e-66
K9FJW5_PEND2 (tr|K9FJW5) DNA topoisomerase OS=Penicillium digita... 259 3e-66
H3CL93_TETNG (tr|H3CL93) DNA topoisomerase (Fragment) OS=Tetraod... 259 3e-66
L1K3I3_GUITH (tr|L1K3I3) Uncharacterized protein OS=Guillardia t... 259 3e-66
F4PE38_BATDJ (tr|F4PE38) Putative uncharacterized protein (Fragm... 259 3e-66
J9K335_ACYPI (tr|J9K335) DNA topoisomerase OS=Acyrthosiphon pisu... 259 3e-66
F9XBA1_MYCGM (tr|F9XBA1) DNA topoisomerase OS=Mycosphaerella gra... 258 4e-66
Q171C3_AEDAE (tr|Q171C3) DNA topoisomerase OS=Aedes aegypti GN=A... 258 4e-66
E3MI31_CAERE (tr|E3MI31) DNA topoisomerase OS=Caenorhabditis rem... 258 4e-66
E9H1M6_DAPPU (tr|E9H1M6) DNA topoisomerase OS=Daphnia pulex GN=D... 258 5e-66
E9DAG1_COCPS (tr|E9DAG1) DNA topoisomerase OS=Coccidioides posad... 258 7e-66
K1QMX0_CRAGI (tr|K1QMX0) DNA topoisomerase OS=Crassostrea gigas ... 258 8e-66
K7IZC3_NASVI (tr|K7IZC3) DNA topoisomerase OS=Nasonia vitripenni... 257 1e-65
B0WGC0_CULQU (tr|B0WGC0) DNA topoisomerase OS=Culex quinquefasci... 257 1e-65
B6K7U4_SCHJY (tr|B6K7U4) DNA topoisomerase OS=Schizosaccharomyce... 256 3e-65
B6A9W0_CRYMR (tr|B6A9W0) DNA topoisomerase OS=Cryptosporidium mu... 256 3e-65
G7XEX1_ASPKW (tr|G7XEX1) DNA topoisomerase OS=Aspergillus kawach... 256 3e-65
G2X7R0_VERDV (tr|G2X7R0) DNA topoisomerase OS=Verticillium dahli... 255 4e-65
J3KKC0_COCIM (tr|J3KKC0) DNA topoisomerase OS=Coccidioides immit... 255 5e-65
D6WYH2_TRICA (tr|D6WYH2) DNA topoisomerase OS=Tribolium castaneu... 254 8e-65
A2QNT8_ASPNC (tr|A2QNT8) DNA topoisomerase OS=Aspergillus niger ... 254 9e-65
G7YVP7_CLOSI (tr|G7YVP7) DNA topoisomerase (Fragment) OS=Clonorc... 254 1e-64
A1CYW8_NEOFI (tr|A1CYW8) DNA topoisomerase OS=Neosartorya fische... 254 1e-64
B8M6R0_TALSN (tr|B8M6R0) DNA topoisomerase OS=Talaromyces stipit... 254 1e-64
Q4Q199_LEIMA (tr|Q4Q199) DNA topoisomerase OS=Leishmania major G... 254 1e-64
G8YNR8_PICSO (tr|G8YNR8) Piso0_001663 protein OS=Pichia sorbitop... 253 1e-64
H3J0J4_STRPU (tr|H3J0J4) DNA topoisomerase OS=Strongylocentrotus... 253 2e-64
Q4WI92_ASPFU (tr|Q4WI92) DNA topoisomerase OS=Neosartorya fumiga... 253 2e-64
B0XU08_ASPFC (tr|B0XU08) DNA topoisomerase OS=Neosartorya fumiga... 253 2e-64
H3FCH9_PRIPA (tr|H3FCH9) DNA topoisomerase OS=Pristionchus pacif... 253 2e-64
A4HPI6_LEIBR (tr|A4HPI6) DNA topoisomerase OS=Leishmania brazili... 253 2e-64
M5E9U0_MALSM (tr|M5E9U0) Genomic scaffold, msy_sf_10 OS=Malassez... 253 2e-64
B6HC62_PENCW (tr|B6HC62) DNA topoisomerase OS=Penicillium chryso... 253 2e-64
I1FRL5_AMPQE (tr|I1FRL5) DNA topoisomerase OS=Amphimedon queensl... 252 3e-64
L1JFZ3_GUITH (tr|L1JFZ3) DNA topoisomerase (Fragment) OS=Guillar... 252 4e-64
A0DEK9_PARTE (tr|A0DEK9) Chromosome undetermined scaffold_48, wh... 251 5e-64
G7E0M5_MIXOS (tr|G7E0M5) Uncharacterized protein OS=Mixia osmund... 251 6e-64
J4GIB6_FIBRA (tr|J4GIB6) DNA topoisomerase OS=Fibroporia radicul... 251 6e-64
E9IAV6_SOLIN (tr|E9IAV6) DNA topoisomerase (Fragment) OS=Solenop... 251 8e-64
E7A0Y6_SPORE (tr|E7A0Y6) DNA topoisomerase OS=Sporisorium reilia... 251 9e-64
B0D1N0_LACBS (tr|B0D1N0) DNA topoisomerase OS=Laccaria bicolor (... 250 1e-63
R9NXV4_9BASI (tr|R9NXV4) Uncharacterized protein OS=Pseudozyma h... 250 1e-63
G3XZ45_ASPNA (tr|G3XZ45) DNA topoisomerase OS=Aspergillus niger ... 250 1e-63
C4Y396_CLAL4 (tr|C4Y396) DNA topoisomerase OS=Clavispora lusitan... 250 1e-63
G3QKQ6_GORGO (tr|G3QKQ6) DNA topoisomerase OS=Gorilla gorilla go... 250 2e-63
C5DKW7_LACTC (tr|C5DKW7) DNA topoisomerase OS=Lachancea thermoto... 249 2e-63
B6Q6V1_PENMQ (tr|B6Q6V1) DNA topoisomerase OS=Penicillium marnef... 249 2e-63
G8YLD9_PICSO (tr|G8YLD9) Piso0_001663 protein OS=Pichia sorbitop... 249 2e-63
Q4PAW5_USTMA (tr|Q4PAW5) DNA topoisomerase OS=Ustilago maydis (s... 249 2e-63
A8Q3Y0_MALGO (tr|A8Q3Y0) DNA topoisomerase OS=Malassezia globosa... 249 3e-63
F2TP38_AJEDA (tr|F2TP38) DNA topoisomerase OS=Ajellomyces dermat... 249 3e-63
A8QH57_BRUMA (tr|A8QH57) DNA topoisomerase III, putative OS=Brug... 249 4e-63
Q016P5_OSTTA (tr|Q016P5) Myosin class 11-1 (ISS) OS=Ostreococcus... 248 4e-63
E9CIX7_CAPO3 (tr|E9CIX7) DNA topoisomerase OS=Capsaspora owczarz... 248 5e-63
E9AT98_LEIMU (tr|E9AT98) DNA topoisomerase OS=Leishmania mexican... 248 5e-63
D8RIM2_SELML (tr|D8RIM2) DNA topoisomerase OS=Selaginella moelle... 248 6e-63
E9NQ03_LEIDO (tr|E9NQ03) DNA topoisomerase OS=Leishmania donovan... 248 6e-63
M7BIP5_CHEMY (tr|M7BIP5) DNA topoisomerase 3-alpha OS=Chelonia m... 248 7e-63
Q0CHD1_ASPTN (tr|Q0CHD1) DNA topoisomerase OS=Aspergillus terreu... 248 7e-63
C0NGZ5_AJECG (tr|C0NGZ5) DNA topoisomerase OS=Ajellomyces capsul... 248 8e-63
C6H6Z0_AJECH (tr|C6H6Z0) DNA topoisomerase OS=Ajellomyces capsul... 247 9e-63
Q55KM2_CRYNB (tr|Q55KM2) DNA topoisomerase OS=Cryptococcus neofo... 247 9e-63
G8BAX5_CANPC (tr|G8BAX5) Putative uncharacterized protein OS=Can... 247 1e-62
B8PK31_POSPM (tr|B8PK31) DNA topoisomerase OS=Postia placenta (s... 247 1e-62
J9FV51_9SPIT (tr|J9FV51) DNA topoisomerase OS=Oxytricha trifalla... 247 1e-62
E2A6W4_CAMFO (tr|E2A6W4) DNA topoisomerase OS=Camponotus florida... 247 1e-62
D5GBK2_TUBMM (tr|D5GBK2) DNA topoisomerase OS=Tuber melanosporum... 247 1e-62
H2Z239_CIOSA (tr|H2Z239) DNA topoisomerase (Fragment) OS=Ciona s... 247 1e-62
J9FBN9_WUCBA (tr|J9FBN9) DNA topoisomerase OS=Wuchereria bancrof... 247 1e-62
H2Z235_CIOSA (tr|H2Z235) DNA topoisomerase (Fragment) OS=Ciona s... 246 2e-62
F6Z6P9_MACMU (tr|F6Z6P9) DNA topoisomerase OS=Macaca mulatta PE=... 246 2e-62
A3GHH1_PICST (tr|A3GHH1) DNA topoisomerase OS=Scheffersomyces st... 246 2e-62
H2Z240_CIOSA (tr|H2Z240) DNA topoisomerase (Fragment) OS=Ciona s... 246 2e-62
C5JDG2_AJEDS (tr|C5JDG2) DNA topoisomerase OS=Ajellomyces dermat... 246 2e-62
C5M7X1_CANTT (tr|C5M7X1) Putative uncharacterized protein OS=Can... 246 2e-62
F4RET6_MELLP (tr|F4RET6) Putative uncharacterized protein (Fragm... 246 3e-62
D8SP39_SELML (tr|D8SP39) DNA topoisomerase OS=Selaginella moelle... 246 3e-62
K7KV90_SOYBN (tr|K7KV90) DNA topoisomerase OS=Glycine max PE=3 SV=1 246 3e-62
A8N7S6_COPC7 (tr|A8N7S6) Putative uncharacterized protein OS=Cop... 245 4e-62
C5GXA3_AJEDR (tr|C5GXA3) DNA topoisomerase OS=Ajellomyces dermat... 245 4e-62
R8BQ02_9PEZI (tr|R8BQ02) Putative dna topoisomerase iii protein ... 245 4e-62
B4Q9Z3_DROSI (tr|B4Q9Z3) DNA topoisomerase OS=Drosophila simulan... 245 5e-62
D8TMQ9_VOLCA (tr|D8TMQ9) DNA topoisomerase OS=Volvox carteri GN=... 245 6e-62
K5W649_PHACS (tr|K5W649) DNA topoisomerase OS=Phanerochaete carn... 244 6e-62
F2PIT5_TRIEC (tr|F2PIT5) DNA topoisomerase OS=Trichophyton equin... 244 7e-62
B3L8C2_PLAKH (tr|B3L8C2) DNA topoisomerase III, putative OS=Plas... 244 7e-62
D8Q3K1_SCHCM (tr|D8Q3K1) DNA topoisomerase OS=Schizophyllum comm... 244 7e-62
E1FR69_LOALO (tr|E1FR69) DNA topoisomerase III OS=Loa loa GN=LOA... 244 7e-62
H8X2J6_CANO9 (tr|H8X2J6) Top3 protein OS=Candida orthopsilosis (... 244 7e-62
B4I5W5_DROSE (tr|B4I5W5) DNA topoisomerase OS=Drosophila sechell... 244 9e-62
B3MN55_DROAN (tr|B3MN55) DNA topoisomerase OS=Drosophila ananass... 244 1e-61
L2GB63_COLGN (tr|L2GB63) DNA topoisomerase OS=Colletotrichum glo... 244 1e-61
K6ULC5_9APIC (tr|K6ULC5) DNA topoisomerase III alpha OS=Plasmodi... 244 1e-61
I7AR84_ENCRO (tr|I7AR84) DNA topoisomerase II OS=Encephalitozoon... 243 2e-61
M9MAK8_9BASI (tr|M9MAK8) DNA topoisomerase III alpha OS=Pseudozy... 243 2e-61
B4PAZ8_DROYA (tr|B4PAZ8) DNA topoisomerase OS=Drosophila yakuba ... 243 2e-61
I2G1E9_USTH4 (tr|I2G1E9) DNA topoisomerase OS=Ustilago hordei (s... 243 2e-61
A6R6R2_AJECN (tr|A6R6R2) DNA topoisomerase OS=Ajellomyces capsul... 243 2e-61
J9W0N6_CRYNH (tr|J9W0N6) DNA topoisomerase OS=Cryptococcus neofo... 243 3e-61
Q5B4H5_EMENI (tr|Q5B4H5) DNA topoisomerase OS=Emericella nidulan... 243 3e-61
Q7Q111_ANOGA (tr|Q7Q111) DNA topoisomerase OS=Anopheles gambiae ... 242 3e-61
E0S6Q9_ENCIT (tr|E0S6Q9) DNA topoisomerase III OS=Encephalitozoo... 242 3e-61
F2S5G3_TRIT1 (tr|F2S5G3) DNA topoisomerase OS=Trichophyton tonsu... 242 3e-61
N1J751_ERYGR (tr|N1J751) DNA topoisomerase III OS=Blumeria grami... 242 4e-61
Q29K61_DROPS (tr|Q29K61) DNA topoisomerase OS=Drosophila pseudoo... 242 4e-61
M1JIJ8_ENCCN (tr|M1JIJ8) DNA topoisomerase III OS=Encephalitozoo... 242 5e-61
B4GWY2_DROPE (tr|B4GWY2) DNA topoisomerase OS=Drosophila persimi... 241 5e-61
N6UAY1_9CUCU (tr|N6UAY1) Uncharacterized protein (Fragment) OS=D... 241 5e-61
B9SN22_RICCO (tr|B9SN22) DNA topoisomerase (Fragment) OS=Ricinus... 241 8e-61
F2SEP2_TRIRC (tr|F2SEP2) DNA topoisomerase OS=Trichophyton rubru... 241 8e-61
C1GBF3_PARBD (tr|C1GBF3) DNA topoisomerase OS=Paracoccidioides b... 241 8e-61
C0S9B3_PARBP (tr|C0S9B3) DNA topoisomerase OS=Paracoccidioides b... 241 8e-61
Q8SS31_ENCCU (tr|Q8SS31) DNA TOPOISOMERASE III OS=Encephalitozoo... 240 1e-60
E5SGH1_TRISP (tr|E5SGH1) DNA topoisomerase OS=Trichinella spiral... 240 1e-60
R7YNU0_9EURO (tr|R7YNU0) Uncharacterized protein OS=Coniosporium... 240 1e-60
F8MMA1_NEUT8 (tr|F8MMA1) Putative uncharacterized protein OS=Neu... 240 1e-60
N1QCT5_9PEZI (tr|N1QCT5) Uncharacterized protein OS=Pseudocercos... 240 2e-60
G4URA7_NEUT9 (tr|G4URA7) Prokaryotic type I DNA topoisomerase OS... 240 2e-60
B9H4K8_POPTR (tr|B9H4K8) DNA topoisomerase OS=Populus trichocarp... 239 2e-60
G0RCU8_HYPJQ (tr|G0RCU8) DNA topoisomerase OS=Hypocrea jecorina ... 239 2e-60
G3AQP6_SPAPN (tr|G3AQP6) DNA topoisomerase OS=Spathaspora passal... 239 2e-60
Q6C0R0_YARLI (tr|Q6C0R0) DNA topoisomerase OS=Yarrowia lipolytic... 239 3e-60
B1YAK4_PYRNV (tr|B1YAK4) DNA topoisomerase type IA central domai... 239 3e-60
D7E725_METEZ (tr|D7E725) DNA topoisomerase OS=Methanohalobium ev... 239 4e-60
B8BZX1_THAPS (tr|B8BZX1) DNA topoisomerase (Fragment) OS=Thalass... 239 4e-60
C9SVD2_VERA1 (tr|C9SVD2) DNA topoisomerase OS=Verticillium albo-... 239 4e-60
Q6FSR2_CANGA (tr|Q6FSR2) DNA topoisomerase OS=Candida glabrata (... 238 4e-60
N4VN06_COLOR (tr|N4VN06) DNA topoisomerase OS=Colletotrichum orb... 238 5e-60
K1WRC8_MARBU (tr|K1WRC8) DNA topoisomerase OS=Marssonina brunnea... 238 6e-60
A1RRI8_PYRIL (tr|A1RRI8) DNA topoisomerase OS=Pyrobaculum island... 238 6e-60
G4TIC8_PIRID (tr|G4TIC8) Related to DNA topoisomerase III alpha ... 238 7e-60
I6UL40_ENCHA (tr|I6UL40) Topoisomerase IA OS=Encephalitozoon hel... 237 9e-60
H2Z241_CIOSA (tr|H2Z241) DNA topoisomerase (Fragment) OS=Ciona s... 237 1e-59
M7XAM1_RHOTO (tr|M7XAM1) DNA topoisomerase III OS=Rhodosporidium... 237 1e-59
B5RUS0_DEBHA (tr|B5RUS0) DEHA2G13376p OS=Debaryomyces hansenii (... 237 1e-59
Q6CJ79_KLULA (tr|Q6CJ79) DNA topoisomerase OS=Kluyveromyces lact... 237 1e-59
M1WBC5_CLAPU (tr|M1WBC5) Related to DNA topoisomerase III OS=Cla... 237 1e-59
Q5KAU9_CRYNJ (tr|Q5KAU9) DNA topoisomerase OS=Cryptococcus neofo... 237 1e-59
Q0U0G1_PHANO (tr|Q0U0G1) DNA topoisomerase OS=Phaeosphaeria nodo... 237 1e-59
I4YDJ6_WALSC (tr|I4YDJ6) DNA topoisomerase OS=Wallemia sebi (str... 237 2e-59
E3Q8J2_COLGM (tr|E3Q8J2) DNA topoisomerase OS=Colletotrichum gra... 236 2e-59
K3WHB4_PYTUL (tr|K3WHB4) Uncharacterized protein OS=Pythium ulti... 236 2e-59
F2QNW2_PICP7 (tr|F2QNW2) DNA topoisomerase III OS=Komagataella p... 236 2e-59
C4QWI9_PICPG (tr|C4QWI9) DNA Topoisomerase III, conserved protei... 236 2e-59
F6JJ45_DROSI (tr|F6JJ45) CG3458 (Fragment) OS=Drosophila simulan... 236 2e-59
F6JNP0_DROSI (tr|F6JNP0) CG3458 (Fragment) OS=Drosophila simulan... 236 2e-59
F6JJ32_DROSI (tr|F6JJ32) CG3458 (Fragment) OS=Drosophila simulan... 236 2e-59
A5K8A9_PLAVS (tr|A5K8A9) DNA topoisomerase III alpha, putative O... 236 2e-59
C4JSQ6_UNCRE (tr|C4JSQ6) DNA topoisomerase OS=Uncinocarpus reesi... 236 2e-59
H3G7Y5_PHYRM (tr|H3G7Y5) Uncharacterized protein (Fragment) OS=P... 236 3e-59
M7U3M0_BOTFU (tr|M7U3M0) Putative dna topoisomerase iii protein ... 236 3e-59
G2YR43_BOTF4 (tr|G2YR43) DNA topoisomerase OS=Botryotinia fuckel... 236 3e-59
J9J1U5_9SPIT (tr|J9J1U5) DNA topoisomerase OS=Oxytricha trifalla... 236 3e-59
C1H2W6_PARBA (tr|C1H2W6) DNA topoisomerase OS=Paracoccidioides b... 235 4e-59
G8JT78_ERECY (tr|G8JT78) DNA topoisomerase OS=Eremothecium cymba... 235 5e-59
K0KF76_WICCF (tr|K0KF76) DNA topoisomerase OS=Wickerhamomyces ci... 235 5e-59
C4VAL6_NOSCE (tr|C4VAL6) Putative uncharacterized protein OS=Nos... 235 6e-59
F2THD6_AJEDA (tr|F2THD6) DNA topoisomerase OS=Ajellomyces dermat... 234 6e-59
Q9LVP1_ARATH (tr|Q9LVP1) DNA topoisomerase OS=Arabidopsis thalia... 234 6e-59
>I1LN46_SOYBN (tr|I1LN46) DNA topoisomerase OS=Glycine max PE=3 SV=1
Length = 863
Score = 1227 bits (3174), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 585/658 (88%), Positives = 605/658 (91%), Gaps = 1/658 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRYLQINTFKPEKFWS++PYI+ +GYEIQLEWQR KLFDINVA MF
Sbjct: 206 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSLHPYIIQNGYEIQLEWQRGKLFDINVAMMF 265
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV+EDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGP MAMQLAERLYTQGF
Sbjct: 266 QKLVSEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGF 325
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYPPSFDFRG LSAQ NNPTWGNYV+GLLTNGY KPRLGTDVGDHPPITPM
Sbjct: 326 ISYPRTESTAYPPSFDFRGVLSAQTNNPTWGNYVQGLLTNGYQKPRLGTDVGDHPPITPM 385
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R AAEDMLGNDAWKLYQYICQHFIGTVSPDCKY RRKVEFSIGGESFHCTGQHV+TKGFT
Sbjct: 386 RSAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYIRRKVEFSIGGESFHCTGQHVVTKGFT 445
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPWLAINDKNIPSFIKGQKIEVSK+ELYEG+T+PPD+LTESELISLMEKNGIGTDASI
Sbjct: 446 AIMPWLAINDKNIPSFIKGQKIEVSKLELYEGSTSPPDFLTESELISLMEKNGIGTDASI 505
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQ+IDPDLCLPDIRSFIEQQITLIAKG
Sbjct: 506 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQTIDPDLCLPDIRSFIEQQITLIAKG 565
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q+DH VVQHVIQQF QKF YFVKKIE MDALFEAQFSTL DSGRILSKCGKCLRYMK+I
Sbjct: 566 QVDHRHVVQHVIQQFTQKFSYFVKKIEDMDALFEAQFSTLTDSGRILSKCGKCLRYMKFI 625
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QPSRLYCG CEEVYYLPQKGTIKLYKELSCPLDNFELL+CSM GPDGKSFPLCPYCY
Sbjct: 626 STQPSRLYCGTCEEVYYLPQKGTIKLYKELSCPLDNFELLICSMPGPDGKSFPLCPYCYI 685
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
NPPFEGIE LINTAKT TSGKIGKGAGMPC LCPHPTCPNSLVSQGVCACPECSGTLVLD
Sbjct: 686 NPPFEGIETLINTAKTGTSGKIGKGAGMPCNLCPHPTCPNSLVSQGVCACPECSGTLVLD 745
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAP+W+LCCNMCNCLVFLAQGAHRISTTK+RCPECDSSIIEVDFNKK TPLEDG+TLH
Sbjct: 746 PVSAPRWKLCCNMCNCLVFLAQGAHRISTTKDRCPECDSSIIEVDFNKKTTPLEDGATLH 805
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
GCILCDELLHSLVEMKH M+DPKMSFRDF
Sbjct: 806 HGCILCDELLHSLVEMKHGRSFRHMSSRGRGRGARKGGRGRGRGGGKMMDPKMSFRDF 863
>G7JBC7_MEDTR (tr|G7JBC7) DNA topoisomerase OS=Medicago truncatula GN=MTR_3g084800
PE=3 SV=1
Length = 1024
Score = 1183 bits (3061), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 570/674 (84%), Positives = 601/674 (89%), Gaps = 13/674 (1%)
Query: 8 IAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDIN 67
I + SYGPCQTPTLGFCVQRYLQINTFKPEKFWS+ PYI+ SGYEI LEWQRSKLFDIN
Sbjct: 352 ICIANSYGPCQTPTLGFCVQRYLQINTFKPEKFWSLQPYIIQSGYEILLEWQRSKLFDIN 411
Query: 68 VATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERL 127
VA MFQKLVA+DG++EVT ISEK ETK RPVGLNTVNLLKVASSALGFGP MAMQLAERL
Sbjct: 412 VAMMFQKLVADDGIVEVTNISEKPETKGRPVGLNTVNLLKVASSALGFGPQMAMQLAERL 471
Query: 128 YTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHP 187
YTQGFISYPRTESTAYPPSFDFR ALSAQ NNPTWGNYVEGLL +GY KPR GTDVGDHP
Sbjct: 472 YTQGFISYPRTESTAYPPSFDFRSALSAQRNNPTWGNYVEGLLASGYQKPRSGTDVGDHP 531
Query: 188 PITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVI 247
PITPM+ A+EDMLGNDAWKLYQYICQ+FIGTVSPDCKY R+KVEF +GGESFHCTGQHVI
Sbjct: 532 PITPMKSASEDMLGNDAWKLYQYICQYFIGTVSPDCKYIRKKVEFQVGGESFHCTGQHVI 591
Query: 248 TKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIG 307
TKGFTAIMPWLAINDK++PSF +GQKI++SKVELYEG+TTPPD+LTESELISLMEKNGIG
Sbjct: 592 TKGFTAIMPWLAINDKSLPSFEEGQKIKLSKVELYEGSTTPPDFLTESELISLMEKNGIG 651
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDASIPVHINNICERNYVQVQAGRKL PTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT
Sbjct: 652 TDASIPVHINNICERNYVQVQAGRKLSPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 711
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKK-----------IEAMDALFEAQFSTLVDSG 416
LIAKGQ+DHHRVVQHVI+QFKQKFCYFVKK IEAMDALFEAQFS LVDSG
Sbjct: 712 LIAKGQVDHHRVVQHVIEQFKQKFCYFVKKVGYLLFSACFWIEAMDALFEAQFSALVDSG 771
Query: 417 RILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM 476
RI+SKCGKCLRYMKYIS QPSRLYCG CEEVY LPQKGTIKLYKEL+CPLDNFELL+CSM
Sbjct: 772 RIMSKCGKCLRYMKYISVQPSRLYCGTCEEVYDLPQKGTIKLYKELTCPLDNFELLICSM 831
Query: 477 -GPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVS 535
GP+GKSFPLCPYCYSNPPFEGI+ LIN+AKT+TS K GKGAGMPC LCPHPTCPNSLVS
Sbjct: 832 PGPEGKSFPLCPYCYSNPPFEGIDTLINSAKTTTSSKTGKGAGMPCNLCPHPTCPNSLVS 891
Query: 536 QGVCACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEV 595
QGVCACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSI+EV
Sbjct: 892 QGVCACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSILEV 951
Query: 596 DFNKKATPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXX 655
DFNKK TPL DGSTLHRGCILCD LLHSLVEMK+
Sbjct: 952 DFNKKTTPLADGSTLHRGCILCDVLLHSLVEMKY-GRGFKSSRGRGRGGRTQRYRGRGRG 1010
Query: 656 XXXMVDPKMSFRDF 669
M+DPKMSFRDF
Sbjct: 1011 NAKMMDPKMSFRDF 1024
>F6I488_VITVI (tr|F6I488) DNA topoisomerase OS=Vitis vinifera
GN=VIT_05s0062g00860 PE=3 SV=1
Length = 821
Score = 1107 bits (2863), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 519/659 (78%), Positives = 576/659 (87%), Gaps = 2/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRYLQINTFKPEKFW+++PYI H+GYE+QLEW+R+KLFD++VA MF
Sbjct: 163 SYGPCQTPTLGFCVQRYLQINTFKPEKFWALHPYITHNGYELQLEWERNKLFDLDVAVMF 222
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
Q LV EDG++EVT+ISEKQE+KSRP GLNTVNLLKVASSALGFGP MAMQLAERLYTQGF
Sbjct: 223 QNLVMEDGIVEVTDISEKQESKSRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGF 282
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF+ L Q NNPTWG+YV+ LL +G+ +PR GTD GDHPPITPM
Sbjct: 283 ISYPRTESTAYPSSFDFKSTLGMQTNNPTWGDYVQKLLDDGFHRPRSGTDAGDHPPITPM 342
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A EDMLGNDAWKLYQY+CQHFIGTVSPDCKY R KVEFSIGGE F C GQHVI KGFT
Sbjct: 343 RAANEDMLGNDAWKLYQYVCQHFIGTVSPDCKYVRNKVEFSIGGEIFRCIGQHVIVKGFT 402
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+N+KN+P F KG+KIEVSKVELYEG T+PPDYL+ESELISLMEKNGIGTDASI
Sbjct: 403 SIMPWLAVNEKNLPQFKKGEKIEVSKVELYEGETSPPDYLSESELISLMEKNGIGTDASI 462
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNICERN+VQVQAGRKLVPT LGI+L+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 463 PVHINNICERNFVQVQAGRKLVPTALGISLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 522
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q+DH RVV+HV+QQFKQKF YFVK+IE MDALFEAQFS L DSGR LSKCGKCLRYMKYI
Sbjct: 523 QVDHSRVVEHVLQQFKQKFIYFVKQIENMDALFEAQFSPLADSGRALSKCGKCLRYMKYI 582
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QPSR+YCG CEEVYYLPQKGTIKLYKEL+CPLDNFELL+ S+ GP+GKSFPLCPYCY+
Sbjct: 583 STQPSRMYCGTCEEVYYLPQKGTIKLYKELTCPLDNFELLIFSLAGPEGKSFPLCPYCYN 642
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L KTS++GK+GKGAGMPC LCPHPTCP+SL++QGVCACPECSGTLVLD
Sbjct: 643 SPPFEGIDTLFGATKTSSTGKLGKGAGMPCFLCPHPTCPHSLIAQGVCACPECSGTLVLD 702
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CNMCNCLV+L QGAH+ISTT++RCPEC+S+I+EVDFNKK TPL DGSTL+
Sbjct: 703 PVSAPKWRLYCNMCNCLVYLPQGAHKISTTRDRCPECESTILEVDFNKKTTPLLDGSTLY 762
Query: 612 RGCILCDELLHSLVEMKH-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
GCILCDELLHSLVEMKH DPKMSFRDF
Sbjct: 763 TGCILCDELLHSLVEMKHGKSFFKRMGSRGRGRGSGRGGFRGRGRGGKWDDPKMSFRDF 821
>M5XLX9_PRUPE (tr|M5XLX9) Uncharacterized protein OS=Prunus persica
GN=PRUPE_ppa001274mg PE=4 SV=1
Length = 866
Score = 1084 bits (2804), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 509/660 (77%), Positives = 565/660 (85%), Gaps = 3/660 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRYLQINTFKPEKFW+V PYI+ GYE+QLEW+R+KLFD +VA MF
Sbjct: 207 SYGPCQTPTLGFCVQRYLQINTFKPEKFWAVRPYIMQKGYELQLEWERNKLFDYDVAVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV EDG+LEVTEI EKQE+KSRP GLNTVNLLKVASSALGFGP MAMQ+AERLYTQGF
Sbjct: 267 QKLVMEDGILEVTEIVEKQESKSRPSGLNTVNLLKVASSALGFGPQMAMQVAERLYTQGF 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFRG L AQ NNPTWG+YV+ LL +GY KPR GTDVGDHPP+TP+
Sbjct: 327 ISYPRTESTAYPSSFDFRGTLGAQVNNPTWGSYVQRLLADGYQKPRSGTDVGDHPPVTPL 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A EDMLGNDAW+LY+YIC HF+GTVSPDCKY R KVEFSIGGE FHC G V+ KGFT
Sbjct: 387 RSATEDMLGNDAWRLYEYICTHFMGTVSPDCKYVRTKVEFSIGGEFFHCVGHRVLVKGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+ +KN+P F KG+KIEVS+V+L+EG T+PPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLAVTEKNLPQFTKGEKIEVSQVDLHEGMTSPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
VHINNICERNYVQV AGRKL PT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 507 SVHINNICERNYVQVLAGRKLGPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH RVVQHV+QQF+QK+ YFVK+IE MDALFEAQFS L DSGR+LSKCGKCLRYMK+I
Sbjct: 567 QADHFRVVQHVLQQFRQKYSYFVKQIENMDALFEAQFSPLADSGRVLSKCGKCLRYMKHI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QPSRLYC CEEVYYLPQKG+IKLYKEL+CPLDNFELL+ SM GPDGKSFPLCPYCY+
Sbjct: 627 STQPSRLYCNTCEEVYYLPQKGSIKLYKELTCPLDNFELLIFSMPGPDGKSFPLCPYCYN 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K+ S ++GKGAGMPC LCPHPTC +SL++QGVCACPECSGTLVLD
Sbjct: 687 SPPFEGIDTLFGAVKSGPSSQLGKGAGMPCFLCPHPTCRHSLIAQGVCACPECSGTLVLD 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRLCCNMCN LV L +GAH+ISTT+ERCPECDS+I+EVDFNKK TPLE+G TL+
Sbjct: 747 PVSAPKWRLCCNMCNFLVLLPEGAHQISTTRERCPECDSTILEVDFNKKTTPLENGETLY 806
Query: 612 RGCILCDELLHSLVEMKHXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
GCILCDELLHSLVEMK+ VDPKMSFRDF
Sbjct: 807 TGCILCDELLHSLVEMKYGKSFFKRLGGRGRGRGSRRGGYRGRGRGTGKKVDPKMSFRDF 866
>B9RRL8_RICCO (tr|B9RRL8) DNA topoisomerase OS=Ricinus communis GN=RCOM_1646110
PE=3 SV=1
Length = 865
Score = 1073 bits (2776), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 502/658 (76%), Positives = 556/658 (84%), Gaps = 1/658 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRYLQI TFKPEKFWS+ P+++ GY++QLEW+R +LFD++VA MF
Sbjct: 208 SYGPCQTPTLGFCVQRYLQIATFKPEKFWSLRPHLIIDGYQLQLEWERHRLFDLDVALMF 267
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK V +DG+LEV +IS+KQETK RP GLNTVNLLKVASSALGFGP MAMQLAERLYTQGF
Sbjct: 268 QKQVLQDGILEVIDISQKQETKGRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGF 327
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF+ LS NN WG+ V LL GY KPRLGTD GDHPPITP+
Sbjct: 328 ISYPRTESTAYPSSFDFKSILSTLLNNSIWGDSVRRLLVEGYHKPRLGTDAGDHPPITPI 387
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A EDMLG DAW+LYQY+CQHFIG+VSPDCKY R KVEFS+GGE FHC GQHVI +GFT
Sbjct: 388 RLATEDMLGKDAWRLYQYVCQHFIGSVSPDCKYVRTKVEFSVGGEFFHCIGQHVIVEGFT 447
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+ +KN+P +KG+KIEV ++EL EG TTPPDYLTESELISLMEKNGIGTDASI
Sbjct: 448 SIMPWLAVTEKNLPQLVKGEKIEVLRMELLEGKTTPPDYLTESELISLMEKNGIGTDASI 507
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNICERNYVQVQAGR+L PT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 508 PVHINNICERNYVQVQAGRRLAPTILGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 567
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH RVVQHV+QQFKQKF YFVK+I+ MDALFEAQFS LVDSGR LSKCGKCLRYMKYI
Sbjct: 568 QADHSRVVQHVLQQFKQKFTYFVKQIDNMDALFEAQFSQLVDSGRALSKCGKCLRYMKYI 627
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYCG CEEVYYLPQKGTIKLYKEL+CPLDNFELL+ SM GP+GK+FPLCPYCY+
Sbjct: 628 STQPPRLYCGTCEEVYYLPQKGTIKLYKELTCPLDNFELLIFSMAGPEGKTFPLCPYCYN 687
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
NPPFEG++ L +K GK+GKGAGMPC LCPHPTC +SL++QGVCACPECSGTLVLD
Sbjct: 688 NPPFEGVDTLFGASKNGNFGKLGKGAGMPCFLCPHPTCRHSLIAQGVCACPECSGTLVLD 747
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CNMCNCLV L QGAHRI+TT+ERCPECDS+IIEVDFNK TPLEDG+TLH
Sbjct: 748 PVSAPKWRLYCNMCNCLVLLPQGAHRIATTRERCPECDSTIIEVDFNKNTTPLEDGATLH 807
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
GCILCD+LLHSLVE+KH DPKMSFRDF
Sbjct: 808 IGCILCDDLLHSLVEVKHGKSFFKRLGAGRRGRGAGRGRGRGRSSGRRGDPKMSFRDF 865
>B9IAB5_POPTR (tr|B9IAB5) Predicted protein OS=Populus trichocarpa
GN=POPTRDRAFT_1099630 PE=3 SV=1
Length = 837
Score = 1060 bits (2742), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 498/658 (75%), Positives = 559/658 (84%), Gaps = 2/658 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRYLQI TFKPEKFW++ P+++ GYE+QLEW+R KLFD++VA MF
Sbjct: 181 SYGPCQTPTLGFCVQRYLQITTFKPEKFWALRPHVMVDGYELQLEWERHKLFDLDVALMF 240
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV +D +LEVT++SEKQE+K RP GLNTVNLLK+ASSALGFGP + MQLAERLY QGF
Sbjct: 241 QKLVLQDRILEVTDMSEKQESKGRPPGLNTVNLLKIASSALGFGPQVTMQLAERLYIQGF 300
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF+G L A ANNP WG+YV+GLL+ GY KP+ G D GDHPPITPM
Sbjct: 301 ISYPRTESTAYPSSFDFKGTLGALANNPMWGDYVQGLLSGGYHKPQSGKDAGDHPPITPM 360
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A EDMLG DAW+LYQY+CQHF+GTVSPDCKY R KVEFSIGGE FHC G HV KGFT
Sbjct: 361 RSANEDMLGRDAWRLYQYVCQHFLGTVSPDCKYTRTKVEFSIGGEFFHCIGLHVTVKGFT 420
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+++KN+P F KG KIEVSKVEL+EG T PPDYL+ESELISLMEKNGIGTDASI
Sbjct: 421 SIMPWLAVSEKNLPQFAKGDKIEVSKVELFEGQTVPPDYLSESELISLMEKNGIGTDASI 480
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
VHINNICERNYVQVQAGRKLVPT LGITL+RGYQ IDPDLCLPDIR FIEQQITL+AKG
Sbjct: 481 SVHINNICERNYVQVQAGRKLVPTALGITLIRGYQCIDPDLCLPDIRGFIEQQITLVAKG 540
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH VVQHV++QFK+K+ YFVK+I+ MDALFEAQFS L DSGR SKCGKCLRYMKYI
Sbjct: 541 EADHSCVVQHVLEQFKRKYSYFVKQIDNMDALFEAQFSPLADSGRAFSKCGKCLRYMKYI 600
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S+QPSRLYCG CEEVYYLPQKGTIKLYKEL+CPLDNFELL+ +M GP+GKSFPLCP CY+
Sbjct: 601 SSQPSRLYCGTCEEVYYLPQKGTIKLYKELTCPLDNFELLIFAMAGPEGKSFPLCPLCYN 660
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+AL +KT +SG +GKGAGMPC LCPHPTC +SL++QGVCACPEC+GTLVLD
Sbjct: 661 SPPFEGIDALFGASKTGSSGMLGKGAGMPCFLCPHPTCRHSLIAQGVCACPECNGTLVLD 720
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
P+SAPKWRL CNMCNCLV L QGAHRISTT+E+CPECDS+IIEVDFNK TPLEDG+TLH
Sbjct: 721 PISAPKWRLYCNMCNCLVLLPQGAHRISTTREQCPECDSTIIEVDFNKNTTPLEDGATLH 780
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
GCILCD LLHSLVE+KH M DPKMSFRDF
Sbjct: 781 VGCILCDNLLHSLVEVKHGKSFFKRAGKWARARGRGAYRGRGRGLGKM-DPKMSFRDF 837
>M0TVE7_MUSAM (tr|M0TVE7) DNA topoisomerase OS=Musa acuminata subsp. malaccensis
PE=3 SV=1
Length = 838
Score = 1056 bits (2730), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 493/658 (74%), Positives = 556/658 (84%), Gaps = 1/658 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+QI TFKPEKFW ++PY++ GYE+Q++W R+K+FD NVA MF
Sbjct: 181 SYGPCQTPTLGFCVQRYMQITTFKPEKFWYLSPYVIKDGYELQMDWDRNKVFDFNVAVMF 240
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLVA DG L+VT+IS K+E+KSRP GLNTVN+LKVASSALGFGP MAMQLAERLYTQGF
Sbjct: 241 QKLVANDGTLKVTDISTKEESKSRPCGLNTVNMLKVASSALGFGPQMAMQLAERLYTQGF 300
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR ALSA NP WGN V+ LL +G+ KPR+G+D GDHPPITPM
Sbjct: 301 ISYPRTESTAYPSSFDFRSALSAHLRNPIWGNDVQILLADGFCKPRMGSDAGDHPPITPM 360
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A EDMLG+DAW+LYQYICQHFIG+VSPDCKY R K+EF+ GGE F+C GQHVI+KGFT
Sbjct: 361 RSATEDMLGSDAWRLYQYICQHFIGSVSPDCKYTRTKIEFTSGGELFYCVGQHVISKGFT 420
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPW+ +++KN+P F G KI + KV+L+EGTT+PPDYL+ESELISLMEKNGIGTDASI
Sbjct: 421 SIMPWMGVSEKNLPQFKNGDKINILKVDLHEGTTSPPDYLSESELISLMEKNGIGTDASI 480
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNICERNYVQV +GR+LVPT LG TL+RGYQ IDPDLCLPDIRSFIEQQITLIAKG
Sbjct: 481 PVHINNICERNYVQVNSGRRLVPTALGTTLIRGYQCIDPDLCLPDIRSFIEQQITLIAKG 540
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH RVV+HV+QQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 541 KADHVRVVEHVLQQFMEKYSYFVKKIEDMDALFEAQFSPLADSGRLLSKCGKCTRYMKYI 600
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S+QP+RLYC CEEVY+LPQ GTIKLYKEL+CPLD FELL+ SM GPDGK+FPLCPYCY+
Sbjct: 601 SSQPTRLYCITCEEVYHLPQNGTIKLYKELACPLDGFELLIFSMAGPDGKTFPLCPYCYN 660
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L T K SGKIGKGAGMPC LCPHPTCP+SL++QGVCACPECSGTLVLD
Sbjct: 661 SPPFEGIDKLFGTLKLGNSGKIGKGAGMPCFLCPHPTCPHSLITQGVCACPECSGTLVLD 720
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRLCCN CNCLV L QGAHRISTT +RCPECDS+IIEVDFNKK T L DG+TLH
Sbjct: 721 PVSAPKWRLCCNTCNCLVSLPQGAHRISTTGKRCPECDSTIIEVDFNKKTTVLSDGATLH 780
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
GCILCDELLHSLVE+KH DPKMSFRDF
Sbjct: 781 EGCILCDELLHSLVEVKHGSSFFRRGRGRGRNRGRGRHRGRGRGGSKHEDPKMSFRDF 838
>K4CWW0_SOLLC (tr|K4CWW0) DNA topoisomerase OS=Solanum lycopersicum
GN=Solyc09g097880.2 PE=3 SV=1
Length = 864
Score = 1022 bits (2643), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 479/665 (72%), Positives = 547/665 (82%), Gaps = 2/665 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCV R+LQI FKPEKFW ++PYI++ GYE++LEW+RS+LFD
Sbjct: 200 LDARVISYGPCQTPTLGFCVDRFLQITMFKPEKFWMLHPYIMYKGYELKLEWERSRLFDA 259
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+V+ MF+ + ED +++V +SEK E+K+RP GLNTVNLLKVASSALGFGP + MQLAER
Sbjct: 260 DVSAMFRNRIIEDRIMKVVRVSEKLESKARPSGLNTVNLLKVASSALGFGPQLTMQLAER 319
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQGFISYPRTESTAYP SFDF+G L A +NP +G Y + LLT+ Y+KPR GTD GDH
Sbjct: 320 LYTQGFISYPRTESTAYPSSFDFKGTLGALVHNPVFGAYAQKLLTDNYIKPRAGTDAGDH 379
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A+ED LGNDAWKLYQYICQHF+GT+SPDCKY R KVEF GGE F C GQ
Sbjct: 380 PPITPMRSASEDSLGNDAWKLYQYICQHFLGTLSPDCKYRRIKVEFESGGEQFQCVGQLA 439
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
KGFT+IMPWLAI++KN+P F G+KIEVSKVEL EG T+PP YL+ESELISLMEK+GI
Sbjct: 440 TVKGFTSIMPWLAISEKNLPEFAVGEKIEVSKVELDEGDTSPPGYLSESELISLMEKHGI 499
Query: 307 GTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQI 366
GTDASI VHINNICERNYVQVQAGR+L PT LGI+L+RGYQ ID DLCLPDIRSFIE QI
Sbjct: 500 GTDASISVHINNICERNYVQVQAGRRLAPTPLGISLIRGYQCIDSDLCLPDIRSFIEHQI 559
Query: 367 TLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCL 426
TL+AKGQ DH VVQHV++QF++KF YFVK+I+ MDALFEAQFS L DSGR+LSKCGKCL
Sbjct: 560 TLVAKGQADHSMVVQHVLEQFRRKFSYFVKQIDNMDALFEAQFSPLSDSGRLLSKCGKCL 619
Query: 427 RYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPL 485
RYMKYIS QP+RLYCG CEEVYY+PQKGT+KLYKEL+CPLDNFELLLCSM GP+GKSFPL
Sbjct: 620 RYMKYISTQPARLYCGTCEEVYYVPQKGTVKLYKELTCPLDNFELLLCSMPGPEGKSFPL 679
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS 545
CPYC++ PPFEGI+ KT S K+GKG GMPC LCPH TCP+S+++QGVCACPECS
Sbjct: 680 CPYCFNCPPFEGIDTFFGAPKTGDSTKLGKGVGMPCFLCPHTTCPHSVIAQGVCACPECS 739
Query: 546 GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLE 605
GTLVLDPVSAPKWRL CN CNCLV L +GAHRISTT+E+CPECDS+IIEVDFNKK TPL+
Sbjct: 740 GTLVLDPVSAPKWRLYCNTCNCLVSLPEGAHRISTTQEKCPECDSTIIEVDFNKKTTPLK 799
Query: 606 DGSTLHRGCILCDELLHSLVEMKH-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKM 664
DG+TLH+GCILCDELLHSLVEMKH DPKM
Sbjct: 800 DGATLHKGCILCDELLHSLVEMKHGRSFSRHGRRGRGRGRGRGGYRGRGRGSNKQQDPKM 859
Query: 665 SFRDF 669
SFRDF
Sbjct: 860 SFRDF 864
>D7LEC3_ARALL (tr|D7LEC3) DNA topoisomerase OS=Arabidopsis lyrata subsp. lyrata
GN=ARALYDRAFT_482130 PE=3 SV=1
Length = 865
Score = 1013 bits (2619), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 475/659 (72%), Positives = 544/659 (82%), Gaps = 4/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+ INTFKPEKFW++ PYI+ GYE+QLEW+R +LFD+ AT+F
Sbjct: 209 SYGPCQTPTLGFCVQRYMHINTFKPEKFWALRPYIIKDGYELQLEWERRRLFDLEAATVF 268
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV E +V ++SEKQE K RP GLNTV+LLKVASSALGFGP AM LAERLYTQGF
Sbjct: 269 QKLVVEGRTAKVMDVSEKQEVKGRPAGLNTVSLLKVASSALGFGPQTAMHLAERLYTQGF 328
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF L AQ +NP WG YV+ LL++G+ KP+ GTD GDHPPITPM
Sbjct: 329 ISYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQRLLSDGFHKPKSGTDAGDHPPITPM 388
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E M+G DAW+LYQY+CQHFIGTVSP+CKY R KVE SIGGE+FHCTGQ V KGFT
Sbjct: 389 RAATEVMVGGDAWRLYQYVCQHFIGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKGFT 448
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPW A+++K +PSF+KG++IEV +VELYEG T PPDYLTESELISLMEK+GIGTDASI
Sbjct: 449 AIMPWSAVDEKKLPSFLKGERIEVIRVELYEGNTAPPDYLTESELISLMEKHGIGTDASI 508
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNI ERNYVQVQAGRKLVPT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 509 PVHINNIGERNYVQVQAGRKLVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 568
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L DSGR LSKCGKCLRYMK+I
Sbjct: 569 QADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLADSGRALSKCGKCLRYMKHI 628
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
+A P RL+CG CEEVYYLPQKGTIKLYKEL+CPLDNFEL++ S+ GP+GKSFPLCPYCY+
Sbjct: 629 TAVPPRLFCGTCEEVYYLPQKGTIKLYKELTCPLDNFELVIYSVPGPEGKSFPLCPYCYN 688
Query: 492 NPPFEGIEALINTAKTSTS-GKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVL 550
+PPFEGI+ L +KT + K G+GMPC LCPHPTC +S+ +QGVCACPEC GTLVL
Sbjct: 689 SPPFEGIDTLFGASKTPNAPAKTKTGSGMPCSLCPHPTCQHSVRNQGVCACPECEGTLVL 748
Query: 551 DPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTL 610
DPVS PKW+L CN+C+C+V L +GAHRI+TT RCPECDS+IIE+DFNKK TPLE+G+TL
Sbjct: 749 DPVSFPKWKLNCNLCSCIVLLPEGAHRIATTSNRCPECDSAIIEIDFNKKTTPLENGATL 808
Query: 611 HRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
H+GC+LCDELL SLVE+KH VDPKMSFRDF
Sbjct: 809 HQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGGRRGSKA--VDPKMSFRDF 865
>M4E275_BRARP (tr|M4E275) DNA topoisomerase OS=Brassica rapa subsp. pekinensis
GN=Bra022875 PE=3 SV=1
Length = 862
Score = 1012 bits (2616), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 474/659 (71%), Positives = 545/659 (82%), Gaps = 4/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+QINTFKPEKFWS+ P+++ GYE+QLEW R +LFD+ A +F
Sbjct: 206 SYGPCQTPTLGFCVQRYMQINTFKPEKFWSLRPHLMKDGYELQLEWDRRRLFDLEAAVVF 265
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV E +V ++S+KQE K RP GLNTVNLLKVASSALGFGP AM LAERLYTQGF
Sbjct: 266 QKLVVEGRTAKVIDVSDKQEVKGRPAGLNTVNLLKVASSALGFGPQTAMHLAERLYTQGF 325
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF L AQ +NP WG YV+ LL++G+ KP+ GTD GDHPPITPM
Sbjct: 326 ISYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQRLLSDGFQKPKSGTDAGDHPPITPM 385
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E ++G DAW+LYQY+CQHFIGTVSP+CKY R KVE SIGGE FHCTGQ V KGFT
Sbjct: 386 RAATEGIVGGDAWRLYQYVCQHFIGTVSPNCKYIRTKVELSIGGEIFHCTGQRVTEKGFT 445
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPW A+++K +PSF+KG+KIEVS+VELYEG T+PPD+LTESELISLMEK+GIGTDASI
Sbjct: 446 AIMPWSAVDEKKLPSFLKGEKIEVSRVELYEGNTSPPDFLTESELISLMEKHGIGTDASI 505
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNI ERNYVQVQ+GRKLVPT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 506 PVHINNIGERNYVQVQSGRKLVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 565
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L DSGR LSKCGKCLRYMK+I
Sbjct: 566 QADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLADSGRALSKCGKCLRYMKHI 625
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
+A P RL+CG CEEVYYLPQKGT+KLYKEL+CPLDNFEL++ S+ G +GKSFPLCPYCY+
Sbjct: 626 TAVPPRLFCGTCEEVYYLPQKGTVKLYKELTCPLDNFELVIYSVPGTEGKSFPLCPYCYN 685
Query: 492 NPPFEGIEALINTAKTST-SGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVL 550
+PPFEGI+ L AKT+ S K G+GMPC LCPHPTCP+SL +QGVCACPEC GTLVL
Sbjct: 686 SPPFEGIDTLFGAAKTANASAKTKTGSGMPCSLCPHPTCPHSLRNQGVCACPECEGTLVL 745
Query: 551 DPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTL 610
DPVS PKW+L CN+C+C+V L +GAHRI+TT RCPECDS+IIE+DFNKK TPL++G+TL
Sbjct: 746 DPVSFPKWKLNCNLCSCIVMLPEGAHRIATTSNRCPECDSAIIEIDFNKKTTPLDNGATL 805
Query: 611 HRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
H+GC+LCDELL SLVE+KH VDPKMSFRDF
Sbjct: 806 HQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGGRRGSKA--VDPKMSFRDF 862
>F4ISQ7_ARATH (tr|F4ISQ7) DNA topoisomerase OS=Arabidopsis thaliana GN=AT2G32000
PE=2 SV=1
Length = 865
Score = 1005 bits (2599), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 471/659 (71%), Positives = 541/659 (82%), Gaps = 4/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+ INTFKPEKFW++ PYI GYE+QLEW+R +LFD+ AT+F
Sbjct: 209 SYGPCQTPTLGFCVQRYMHINTFKPEKFWALRPYIRKDGYELQLEWERRRLFDLEAATVF 268
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV E +V ++SEKQE K RP GLNTVNLLKVASSALGFGP AM LAERLYTQGF
Sbjct: 269 QKLVVEGRTAKVMDVSEKQEVKGRPAGLNTVNLLKVASSALGFGPQTAMHLAERLYTQGF 328
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF L AQ +NP WG YV+ LL++G+ P+ GTD GDHPPITPM
Sbjct: 329 ISYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQRLLSDGFHMPKSGTDAGDHPPITPM 388
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E M+G DAW+LYQY+CQHF+GTVSP+CKY R KVE SIGGE+FHCTGQ V KGFT
Sbjct: 389 RAATEVMVGGDAWRLYQYVCQHFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKGFT 448
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPW A+++K +PSF+KG++IEV +VELYEG T PPDYLTESELISLMEK+GIGTDASI
Sbjct: 449 AIMPWSAVDEKKLPSFLKGERIEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTDASI 508
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
VHINNI ERNYVQVQ+GRK+VPT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 509 AVHINNIGERNYVQVQSGRKMVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 568
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L DSGR LSKCGKCLRYMK+I
Sbjct: 569 QADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLADSGRALSKCGKCLRYMKHI 628
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
+A P RL+CG CEEVYYLPQKGT+KLYKEL+CPLDNFEL++ S+ GP+GKSFPLCPYCY+
Sbjct: 629 TAVPPRLFCGTCEEVYYLPQKGTVKLYKELTCPLDNFELVIYSVPGPEGKSFPLCPYCYN 688
Query: 492 NPPFEGIEALINTAKTSTS-GKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVL 550
+PPFEGI+ L +KT + K GAGMPC LCPHPTC +S+ +QGVCACPEC GTLVL
Sbjct: 689 SPPFEGIDTLFGASKTPNAPAKTKTGAGMPCSLCPHPTCQHSVRNQGVCACPECEGTLVL 748
Query: 551 DPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTL 610
DPVS PKW+L CN+C+C+V L +GAHRI+TT RCPECDS+IIE+DFNKK TPLE+G+TL
Sbjct: 749 DPVSFPKWKLNCNLCSCIVLLPEGAHRITTTSNRCPECDSAIIEIDFNKKTTPLENGATL 808
Query: 611 HRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
H+GC+LCDELL SLVE+KH VDPKMSFRDF
Sbjct: 809 HQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGGRRGSKS--VDPKMSFRDF 865
>Q680E4_ARATH (tr|Q680E4) DNA topoisomerase OS=Arabidopsis thaliana GN=AT2G32000
PE=2 SV=1
Length = 838
Score = 1003 bits (2594), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 471/659 (71%), Positives = 541/659 (82%), Gaps = 4/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+ INTFKPEKFW++ PYI GYE+QLEW+R +LFD+ AT+F
Sbjct: 182 SYGPCQTPTLGFCVQRYMHINTFKPEKFWALRPYIRKDGYELQLEWERRRLFDLEAATVF 241
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV E +V ++SEKQE K RP GLNTVNLLKVASSALGFGP AM LAERLYTQGF
Sbjct: 242 QKLVVEGRTAKVMDVSEKQEVKGRPAGLNTVNLLKVASSALGFGPQTAMHLAERLYTQGF 301
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF L AQ +NP WG YV+ LL++G+ P+ GTD GDHPPITPM
Sbjct: 302 ISYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQRLLSDGFHMPKSGTDAGDHPPITPM 361
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E M+G DAW+LYQY+CQHF+GTVSP+CKY R KVE SIGGE+FHCTGQ V KGFT
Sbjct: 362 RAATEVMVGGDAWRLYQYVCQHFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKGFT 421
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPW A+++K +PSF+KG++IEV +VELYEG T PPDYLTESELISLMEK+GIGTDASI
Sbjct: 422 AIMPWSAVDEKKLPSFLKGERIEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTDASI 481
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
VHINNI ERNYVQVQ+GRK+VPT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 482 AVHINNIGERNYVQVQSGRKMVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 541
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L DSGR LSKCGKCLRYMK+I
Sbjct: 542 QADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLADSGRALSKCGKCLRYMKHI 601
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
+A P RL+CG CEEVYYLPQKGT+KLYKEL+CPLDNFEL++ S+ GP+GKSFPLCPYCY+
Sbjct: 602 TAVPPRLFCGTCEEVYYLPQKGTVKLYKELTCPLDNFELVIYSVPGPEGKSFPLCPYCYN 661
Query: 492 NPPFEGIEALINTAKTSTS-GKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVL 550
+PPFEGI+ L +KT + K GAGMPC LCPHPTC +S+ +QGVCACPEC GTLVL
Sbjct: 662 SPPFEGIDTLFGASKTPNAPAKTKTGAGMPCSLCPHPTCQHSVRNQGVCACPECEGTLVL 721
Query: 551 DPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTL 610
DPVS PKW+L CN+C+C+V L +GAHRI+TT RCPECDS+IIE+DFNKK TPLE+G+TL
Sbjct: 722 DPVSFPKWKLNCNLCSCIVLLPEGAHRITTTSNRCPECDSAIIEIDFNKKTTPLENGATL 781
Query: 611 HRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
H+GC+LCDELL SLVE+KH VDPKMSFRDF
Sbjct: 782 HQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGGRRGSKS--VDPKMSFRDF 838
>R0FVG1_9BRAS (tr|R0FVG1) Uncharacterized protein OS=Capsella rubella
GN=CARUB_v10022619mg PE=4 SV=1
Length = 864
Score = 1000 bits (2586), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 470/659 (71%), Positives = 541/659 (82%), Gaps = 5/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+ INTFKPEKFW++ PYI GYE+QLEW+R +LFD+ AT+F
Sbjct: 209 SYGPCQTPTLGFCVQRYMHINTFKPEKFWALRPYIAKDGYELQLEWERRRLFDMEAATVF 268
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV E +V ++SEKQE K RP GLNTVNLLKVASSALGFGP AM LAERLYTQGF
Sbjct: 269 QKLVVEGRTAKVMDVSEKQEVKGRPAGLNTVNLLKVASSALGFGPQTAMHLAERLYTQGF 328
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF L AQ +NP WG YV+ LL++G+ KP+ GTD GDHPPITPM
Sbjct: 329 ISYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQRLLSDGFHKPKSGTDAGDHPPITPM 388
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A EDM+G DAW+LYQY+CQHFIGTVS +CKY R KVE SIGGE+FHCTGQ V KGFT
Sbjct: 389 RAATEDMVGGDAWRLYQYVCQHFIGTVSHNCKYIRTKVELSIGGETFHCTGQRVTEKGFT 448
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPW A+++K +PSF+KG++IEV +VE+YEG T PPD+LTESELISLMEK+GIGTDASI
Sbjct: 449 AIMPWSAVDEKKLPSFLKGERIEVLRVEMYEGNTAPPDFLTESELISLMEKHGIGTDASI 508
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNI ERNYVQVQ+GRKLVPT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 509 PVHINNIGERNYVQVQSGRKLVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 568
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L SGR LSKCGKCLRYMK+I
Sbjct: 569 QADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLAGSGRPLSKCGKCLRYMKHI 628
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
+A P RL+CG CEEVYYLPQKGT+KLYKEL+CPLDNFEL++ S+ G +GKSFPLCPYCY+
Sbjct: 629 TAVPPRLFCGTCEEVYYLPQKGTVKLYKELTCPLDNFELVIYSVPGAEGKSFPLCPYCYN 688
Query: 492 NPPFEGIEALINTAKTSTS-GKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVL 550
+PPFEGI+ L +KT + K G+GMPC LCPH TC +S+ +QGVCACPEC GTLVL
Sbjct: 689 SPPFEGIDTLFGASKTPNAPAKSKTGSGMPCSLCPHLTCQHSVRNQGVCACPECEGTLVL 748
Query: 551 DPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTL 610
DPVS PKW+L CN+C+C+VFL +GAHRI+TT RCPECDS+IIE+DFNKK TPLE+G+TL
Sbjct: 749 DPVSFPKWKLNCNLCSCIVFLPEGAHRIATTGNRCPECDSAIIEIDFNKKTTPLENGATL 808
Query: 611 HRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
H+GC+LCDELL SLVE+KH VDPKMSFRDF
Sbjct: 809 HQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGRRGSKA---VDPKMSFRDF 864
>Q56YZ6_ARATH (tr|Q56YZ6) DNA topoisomerase OS=Arabidopsis thaliana GN=At2g32000
PE=2 SV=1
Length = 865
Score = 996 bits (2575), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 469/659 (71%), Positives = 538/659 (81%), Gaps = 4/659 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY+ INTFKPEKFW++ P I GYE+QLEW+R +LFD+ AT+F
Sbjct: 209 SYGPCQTPTLGFCVQRYMHINTFKPEKFWALRPCIRKDGYELQLEWERRRLFDLEAATVF 268
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QKLV E +V ++SEKQE K RP GLNTVNLLKVASSALGFGP AM LAERLYTQGF
Sbjct: 269 QKLVVEGRTAKVMDVSEKQEVKGRPAGLNTVNLLKVASSALGFGPQTAMHLAERLYTQGF 328
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDF L AQ +NP WG YV+ LL++G+ P+ GTD GDHPPITPM
Sbjct: 329 ISYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQRLLSDGFHMPKSGTDAGDHPPITPM 388
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E M+G AW+LYQY+CQHF+GTVSP+CKY R KVE SIGGE+FHCTGQ V KGFT
Sbjct: 389 RAATEVMVGGVAWRLYQYVCQHFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKGFT 448
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
AIMPW A+++K +PSF+KG++IEV +VELYEG T PPDYLTESELISLMEK+GIGTDASI
Sbjct: 449 AIMPWSAVDEKKLPSFLKGERIEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTDASI 508
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
VHINNI ERNYVQVQ+GRK+VPT LGITL+RGYQ IDPDLCLPDIRSFIEQQITL+AKG
Sbjct: 509 AVHINNIGERNYVQVQSGRKMVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKG 568
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
Q DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L DSGR LSKCGKCLRYMK+I
Sbjct: 569 QADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLADSGRALSKCGKCLRYMKHI 628
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
+A P RL+CG CEEVYYLPQKGT+KLYKEL CPLDNFEL++ S+ GP+GKSFPLCPYCY+
Sbjct: 629 TAVPPRLFCGTCEEVYYLPQKGTVKLYKELICPLDNFELVIYSVPGPEGKSFPLCPYCYN 688
Query: 492 NPPFEGIEALINTAKTSTS-GKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVL 550
+PPFEGI+ L +KT + K GAGMPC LCPHPTC +S+ +QGVCACPEC GTLVL
Sbjct: 689 SPPFEGIDTLFGASKTPNAPAKTKTGAGMPCSLCPHPTCQHSVRNQGVCACPECEGTLVL 748
Query: 551 DPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTL 610
DPVS PKW+L CN+C+C+V L +GAHRI+TT RCPECDS+IIE+DFNKK TPLE+G+TL
Sbjct: 749 DPVSFPKWKLNCNLCSCIVLLPEGAHRITTTSNRCPECDSAIIEIDFNKKTTPLENGATL 808
Query: 611 HRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
H+GC+LCDELL SLVE+KH VDPKMSFRDF
Sbjct: 809 HQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGGRRGSKS--VDPKMSFRDF 865
>B9G4E5_ORYSJ (tr|B9G4E5) DNA topoisomerase OS=Oryza sativa subsp. japonica
GN=OsJ_29901 PE=2 SV=1
Length = 729
Score = 993 bits (2566), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 464/662 (70%), Positives = 530/662 (80%), Gaps = 3/662 (0%)
Query: 11 YFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVAT 70
Y YGPCQTPTLGFCVQRY QI TFKPEKFWS+ Y++ G EIQLEW R KLFD +V
Sbjct: 68 YIRYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTV 127
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MFQK+VA DG+L+VT+IS K+E K+RP GLNTVNLLKVASSALG GP AM LAERLYTQ
Sbjct: 128 MFQKMVASDGILKVTDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHLAERLYTQ 187
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
GFISYPRTESTAYP SFDFR AL+A A+NP W N V LL G++KP+ G D GDHPPIT
Sbjct: 188 GFISYPRTESTAYPSSFDFRSALAALAHNPLWSNDVRTLLDTGFVKPKQGHDAGDHPPIT 247
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PMR A E+ LG DAW+LYQYICQHFIGTVSPDC+Y R +EF+ GGE+FHC G V +KG
Sbjct: 248 PMRLATEEALGTDAWRLYQYICQHFIGTVSPDCRYTRTSIEFTSGGETFHCVGNRVTSKG 307
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
FT+IMPWLA+++ NIP++ KG + + KV++YEG+TTPPDYL+ESELISLMEKNGIGTDA
Sbjct: 308 FTSIMPWLAVSENNIPAYKKGDAVSIHKVDIYEGSTTPPDYLSESELISLMEKNGIGTDA 367
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIPVH+NNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIR FIEQQITLIA
Sbjct: 368 SIPVHVNNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRRFIEQQITLIA 427
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
KG+ DH +VVQHV+QQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMK
Sbjct: 428 KGEADHLQVVQHVLQQFMKKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCARYMK 487
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYC 489
YIS QP RLYC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+C
Sbjct: 488 YISTQPMRLYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFC 547
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLV 549
Y++PPFEGI+ L K +GK+GKGAGMPC LC HPTC S+++QGVCACPEC+GTL+
Sbjct: 548 YNSPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCLHPTCKQSMITQGVCACPECTGTLI 607
Query: 550 LDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGST 609
LDPVSAPKWRL CN CNC+V L AH+ISTT ++CP C+S+IIEVDFNKK TPL+DG+T
Sbjct: 608 LDPVSAPKWRLYCNRCNCIVLLPHAAHKISTTDKKCPTCESTIIEVDFNKKTTPLKDGAT 667
Query: 610 LHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV--DPKMSFR 667
LH GCILCDELLHSL+EMKH DPKMSFR
Sbjct: 668 LHEGCILCDELLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSSRGRRGSSRHDDPKMSFR 727
Query: 668 DF 669
DF
Sbjct: 728 DF 729
>Q0J0S6_ORYSJ (tr|Q0J0S6) DNA topoisomerase OS=Oryza sativa subsp. japonica
GN=Os09g0500600 PE=2 SV=1
Length = 866
Score = 993 bits (2566), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 464/660 (70%), Positives = 530/660 (80%), Gaps = 3/660 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QI TFKPEKFWS+ Y++ G EIQLEW R KLFD +V MF
Sbjct: 207 SYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+VA DG+L+VT+IS K+E K+RP GLNTVNLLKVASSALG GP AM LAERLYTQGF
Sbjct: 267 QKMVASDGILKVTDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHLAERLYTQGF 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR AL+A A+NP W N V LL G++KP+ G D GDHPPITPM
Sbjct: 327 ISYPRTESTAYPSSFDFRSALAALAHNPLWSNDVRTLLDTGFVKPKQGHDAGDHPPITPM 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E+ LG DAW+LYQYICQHFIGTVSPDC+Y R +EF+ GGE+FHC G V +KGFT
Sbjct: 387 RLATEEALGTDAWRLYQYICQHFIGTVSPDCRYTRTSIEFTSGGETFHCVGNRVTSKGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+++ NIP++ KG + + KV++YEG+TTPPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLAVSENNIPAYKKGDAVSIHKVDIYEGSTTPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVH+NNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIR FIEQQITLIAKG
Sbjct: 507 PVHVNNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRRFIEQQITLIAKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +VVQHV+QQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 567 EADHLQVVQHVLQQFMKKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCARYMKYI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+CY+
Sbjct: 627 STQPMRLYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFCYN 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K +GK+GKGAGMPC LC HPTC S+++QGVCACPEC+GTL+LD
Sbjct: 687 SPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCLHPTCKQSMITQGVCACPECTGTLILD 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CN CNC+V L AH+ISTT ++CP C+S+IIEVDFNKK TPL+DG+TLH
Sbjct: 747 PVSAPKWRLYCNRCNCIVLLPHAAHKISTTDKKCPTCESTIIEVDFNKKTTPLKDGATLH 806
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV--DPKMSFRDF 669
GCILCDELLHSL+EMKH DPKMSFRDF
Sbjct: 807 EGCILCDELLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSSRGRRGSSRHDDPKMSFRDF 866
>I1QQ61_ORYGL (tr|I1QQ61) DNA topoisomerase OS=Oryza glaberrima PE=3 SV=1
Length = 866
Score = 990 bits (2560), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 463/660 (70%), Positives = 529/660 (80%), Gaps = 3/660 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QI TFKPEKFWS+ Y++ G EIQLEW R KLFD +V MF
Sbjct: 207 SYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+V DG+L+VT+IS K+E K+RP GLNTVNLLKVASSALG GP AM LAERLYTQGF
Sbjct: 267 QKMVTSDGILKVTDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHLAERLYTQGF 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR AL+A A+NP W N V LL G++KP+ G D GDHPPITPM
Sbjct: 327 ISYPRTESTAYPSSFDFRSALAALAHNPLWSNDVRTLLDTGFVKPKQGHDAGDHPPITPM 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E+ LG DAW+LYQYICQHFIGTVSPDC+Y R +EF+ GGE+FHC G V +KGFT
Sbjct: 387 RLATEEALGTDAWRLYQYICQHFIGTVSPDCRYTRTSIEFTSGGETFHCVGNRVTSKGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+++ NIP++ KG + + KV++YEG+TTPPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLAVSENNIPAYKKGDAVSIHKVDIYEGSTTPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVH+NNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIR FIEQQITLIAKG
Sbjct: 507 PVHVNNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRRFIEQQITLIAKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +VVQHV+QQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 567 EADHLQVVQHVLQQFMKKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCARYMKYI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+CY+
Sbjct: 627 STQPMRLYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFCYN 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K +GK+GKGAGMPC LC HPTC S+++QGVCACPEC+GTL+LD
Sbjct: 687 SPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCLHPTCKQSMITQGVCACPECTGTLILD 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CN CNC+V L AH+ISTT ++CP C+S+IIEVDFNKK TPL+DG+TLH
Sbjct: 747 PVSAPKWRLYCNRCNCIVLLPHAAHKISTTDKKCPTCESTIIEVDFNKKTTPLKDGATLH 806
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV--DPKMSFRDF 669
GCILCDELLHSL+EMKH DPKMSFRDF
Sbjct: 807 EGCILCDELLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSTRGRRGSSRHDDPKMSFRDF 866
>C5X4M3_SORBI (tr|C5X4M3) DNA topoisomerase OS=Sorghum bicolor GN=Sb02g029000
PE=3 SV=1
Length = 866
Score = 989 bits (2557), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/662 (70%), Positives = 526/662 (79%), Gaps = 5/662 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QI TFKPEKFWS+ YI+ EIQLEW R KLFD +V MF
Sbjct: 205 SYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYIIKDSDEIQLEWDRKKLFDFDVTVMF 264
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+V DG L+V ++S K+E K+RP GLNTVN+LKVASSALG GP AM LAERLYTQGF
Sbjct: 265 QKMVISDGSLKVADVSVKEECKTRPSGLNTVNMLKVASSALGIGPQTAMHLAERLYTQGF 324
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFRGAL+A NNP W N V LL G++KPR G D GDHPPITPM
Sbjct: 325 ISYPRTESTAYPSSFDFRGALAALLNNPLWSNDVRTLLDAGFVKPRQGHDAGDHPPITPM 384
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E LG DAW+LYQYICQHFIGTVSPDC+Y R +EF+ GGE+FHC G V +KGFT
Sbjct: 385 RSATEAALGTDAWRLYQYICQHFIGTVSPDCRYTRTAIEFTSGGETFHCVGYRVTSKGFT 444
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLAI++ ++P+F KG + + KV++YEG+TTPPDYLTESELISLMEKNGIGTDASI
Sbjct: 445 SIMPWLAISENSLPAFKKGDSVSIHKVDIYEGSTTPPDYLTESELISLMEKNGIGTDASI 504
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIAKG
Sbjct: 505 PVHINNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRSFIEQQITLIAKG 564
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH RV+QHVIQQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 565 KADHLRVIQHVIQQFMKKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCGRYMKYI 624
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYC CE+VYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+CY+
Sbjct: 625 STQPMRLYCITCEDVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFCYN 684
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
PPFEGI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVCACPECSGTL+LD
Sbjct: 685 CPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGTLILD 744
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CNMCNC+V L AHRI+TT ++C C+S+IIEVDFNKK TPL+DG+TLH
Sbjct: 745 PVSAPKWRLYCNMCNCIVLLPHAAHRITTTDKKCLTCESTIIEVDFNKKTTPLQDGATLH 804
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXMVDPKMSFR 667
GCILCD+LLHSL+EMKH DPKMSFR
Sbjct: 805 EGCILCDDLLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSSRGRGRLGNSRYDDPKMSFR 864
Query: 668 DF 669
DF
Sbjct: 865 DF 866
>B8BD52_ORYSI (tr|B8BD52) DNA topoisomerase OS=Oryza sativa subsp. indica
GN=OsI_31918 PE=2 SV=1
Length = 866
Score = 988 bits (2554), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 462/660 (70%), Positives = 529/660 (80%), Gaps = 3/660 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QI TFKPEKFWS+ Y++ G EIQLEW R KLFD +V MF
Sbjct: 207 SYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+VA G+L+VT+IS K+E K+RP GLNTVNLLKVASSALG GP AM LAERLYTQGF
Sbjct: 267 QKMVASYGILKVTDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHLAERLYTQGF 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR AL+A A+NP W N V LL G++KP+ G D GDHPPITPM
Sbjct: 327 ISYPRTESTAYPSSFDFRSALAALAHNPLWSNDVRTLLDTGFVKPKQGHDAGDHPPITPM 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E+ LG DAW+LYQYICQHFIGTVSPDC+Y R +EF+ GGE+FHC G V ++GFT
Sbjct: 387 RLATEEALGTDAWRLYQYICQHFIGTVSPDCRYTRTSIEFTSGGETFHCVGNRVTSEGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+++ NIP++ KG + + KV++YEG+TTPPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLAVSENNIPAYKKGDAVSIHKVDIYEGSTTPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVH+NNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIR FIEQQITLIAKG
Sbjct: 507 PVHVNNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRRFIEQQITLIAKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +VVQHV+QQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 567 EADHLQVVQHVLQQFMKKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCARYMKYI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+CY+
Sbjct: 627 STQPMRLYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFCYN 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K +GK+GKGAGMPC LC HPTC S+++QGVCACPEC+GTL+LD
Sbjct: 687 SPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCLHPTCKQSMITQGVCACPECTGTLILD 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CN CNC+V L AH+ISTT ++CP C+S+IIEVDFNKK TPL+DG+TLH
Sbjct: 747 PVSAPKWRLYCNRCNCIVLLPHAAHKISTTDKKCPTCESTIIEVDFNKKTTPLKDGATLH 806
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV--DPKMSFRDF 669
GCILCDELLHSL+EMKH DPKMSFRDF
Sbjct: 807 EGCILCDELLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSSRGRRGSSRHDDPKMSFRDF 866
>K3ZQL5_SETIT (tr|K3ZQL5) DNA topoisomerase OS=Setaria italica GN=Si028895m.g
PE=3 SV=1
Length = 868
Score = 987 bits (2551), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 461/662 (69%), Positives = 528/662 (79%), Gaps = 5/662 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QI TFKPEKFWS+ YI+ +G EIQLEW R KLFD +V MF
Sbjct: 207 SYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYIIKNGDEIQLEWDRKKLFDFDVTVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+VA DG L++ ++S K+E K+RP GLNTVN+LKVASSALG GP AM LAERLYTQGF
Sbjct: 267 QKMVASDGTLKIADVSVKEECKTRPSGLNTVNMLKVASSALGIGPQTAMHLAERLYTQGF 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFRGAL+ +NP W N V LL G++KPR G D GDHPPITPM
Sbjct: 327 ISYPRTESTAYPASFDFRGALAVLVHNPLWSNDVRTLLDAGFVKPRQGHDAGDHPPITPM 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E+ LG DAW+LYQYI QHFIGTVSPDC+Y R +EF+ GGE+FHC G V KGFT
Sbjct: 387 RSATEEALGTDAWRLYQYISQHFIGTVSPDCRYTRTAIEFTSGGETFHCVGYRVTHKGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWL++++ ++P+F KG + + KV++YEG+TTPPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLSVSENSLPAFRKGDSVSIHKVDIYEGSTTPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIAKG
Sbjct: 507 PVHINNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRSFIEQQITLIAKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +V+QHVIQQF +K+ YFVKKIE+MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 567 KADHRQVIQHVIQQFMKKYSYFVKKIESMDALFEAQFSPLADSGRLLSKCGKCGRYMKYI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYC CE+VYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+CY+
Sbjct: 627 STQPMRLYCITCEDVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFCYT 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
NPPFEGI+ L K +GK+ KGAGMPC LCPHPTC S+++QGVCACPECSGTL+LD
Sbjct: 687 NPPFEGIDKLFGALKIDDTGKVAKGAGMPCCLCPHPTCKQSMITQGVCACPECSGTLILD 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CNMCNC+V L AHRISTT ++C C+S+IIEVDFNKK TPL+DG+TLH
Sbjct: 747 PVSAPKWRLYCNMCNCIVLLPHAAHRISTTDKKCLTCESTIIEVDFNKKTTPLQDGATLH 806
Query: 612 RGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV----DPKMSFR 667
GCILCD+LLHSL+EMKH DPKMSFR
Sbjct: 807 EGCILCDDLLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSSRGRGRRGNSRYDDPKMSFR 866
Query: 668 DF 669
DF
Sbjct: 867 DF 868
>I1IRH1_BRADI (tr|I1IRH1) DNA topoisomerase OS=Brachypodium distachyon
GN=BRADI4G34290 PE=3 SV=1
Length = 868
Score = 985 bits (2547), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 464/662 (70%), Positives = 524/662 (79%), Gaps = 5/662 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QINTFKPEKFWS+ Y++ G EIQLEW R KLFD +V MF
Sbjct: 207 SYGPCQTPTLGFCVQRYQQINTFKPEKFWSLRTYVIKDGDEIQLEWDRKKLFDFDVTVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+VA DG L VT+IS K+E K+RP GLNTVNLLKVASSALG GP AM +AERLYTQG+
Sbjct: 267 QKMVANDGTLIVTDISVKEECKARPSGLNTVNLLKVASSALGIGPQTAMHMAERLYTQGY 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR LSA +NP W N + L+ G++KPR G D GDHPPITPM
Sbjct: 327 ISYPRTESTAYPASFDFRSVLSALVHNPLWSNNIRTLMDAGFVKPRQGHDAGDHPPITPM 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A+E+ L DAW+LYQYICQHFIGTVSPDC+Y R VEF+ GGE F C G V +KGFT
Sbjct: 387 RSASEEALETDAWRLYQYICQHFIGTVSPDCRYTRTAVEFTSGGEIFRCVGHRVTSKGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+ + N+P+F G + + KV++YEG+TTPPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLAVAENNLPTFKNGDTVSIHKVDIYEGSTTPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNI ERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIAKG
Sbjct: 507 PVHINNISERNYVQVNSGRRLVPTALGTTLIRGYQCIDADLCLPDIRSFIEQQITLIAKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +V+QHVIQQF +K+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 567 KADHLQVIQHVIQQFMKKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCGRYMKYI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP R+YC CEEVYYLPQ GTIKLYKE+ CPLD FELLL SM GPD KSFPLCP CY+
Sbjct: 627 STQPMRMYCITCEEVYYLPQNGTIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPCCYN 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVCACPECSGTL+LD
Sbjct: 687 SPPFEGIDKLFGAIKLDDTGKLGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGTLILD 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CNMCNC+V L AHRI+TT ++C C+S+IIEVDFNKKATPLEDG+TLH
Sbjct: 747 PVSAPKWRLLCNMCNCVVLLPHAAHRITTTDKKCSTCESTIIEVDFNKKATPLEDGATLH 806
Query: 612 RGCILCDELLHSLVEMKHXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFR 667
GCILCDELLHSL+EMKH DPKMSFR
Sbjct: 807 EGCILCDELLHSLIEMKHGKSFFMRRGRGRGRGRARGRGGSRGRGRRGNSRHDDPKMSFR 866
Query: 668 DF 669
DF
Sbjct: 867 DF 868
>J3MYW0_ORYBR (tr|J3MYW0) DNA topoisomerase OS=Oryza brachyantha GN=OB09G21890
PE=3 SV=1
Length = 868
Score = 985 bits (2547), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 457/662 (69%), Positives = 529/662 (79%), Gaps = 5/662 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QI TFKPEKFWS+ Y++ G EIQLEW R KLFD +V MF
Sbjct: 207 SYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTVMF 266
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+VA DG+L+VT+IS K+E K+RP GLNTVNLLKVASSALG GP AM LAERLYTQGF
Sbjct: 267 QKMVASDGVLKVTDISVKEECKARPSGLNTVNLLKVASSALGIGPQTAMHLAERLYTQGF 326
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR AL+A +NP W N V LL GY+KP+ G D GDHPP+TPM
Sbjct: 327 ISYPRTESTAYPSSFDFRSALAALVHNPLWTNDVRTLLDAGYVKPKQGHDAGDHPPVTPM 386
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E+ LG DAW+LYQYICQHFIGT+SPDC+Y R +EF+ GGE+FHC G V +KGFT
Sbjct: 387 RLATEEALGTDAWRLYQYICQHFIGTISPDCRYTRTSIEFASGGETFHCVGYRVTSKGFT 446
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+++ N+P+F KG + + K+++YEG+T+PPDYL+ESELISLMEKNGIGTDASI
Sbjct: 447 SIMPWLAVSENNVPAFKKGDTVNIHKIDIYEGSTSPPDYLSESELISLMEKNGIGTDASI 506
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVH+NNICERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIR FIEQQITL++KG
Sbjct: 507 PVHVNNICERNYVQVNSGRRLVPTPLGTTLIRGYQCIDADLCLPDIRRFIEQQITLVSKG 566
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +VVQHV+QQF QK+ YFVKKIE MDALFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 567 EADHLQVVQHVLQQFMQKYSYFVKKIENMDALFEAQFSPLADSGRLLSKCGKCARYMKYI 626
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP RLYC CE+VYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP+CY+
Sbjct: 627 STQPMRLYCVTCEDVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPFCYN 686
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K +GK+GKGAGMPC LC HPTC S+++QGVCACPEC+GTL+L
Sbjct: 687 SPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCLHPTCKQSMITQGVCACPECTGTLILH 746
Query: 552 PVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLH 611
PVSAPKWRL CN CNC+V L Q AH+I+TT ++CP C+S+IIEVDFNKK TPL+DG+TLH
Sbjct: 747 PVSAPKWRLYCNKCNCIVLLPQAAHKIATTDKKCPTCESTIIEVDFNKKTTPLKDGATLH 806
Query: 612 RGCILCDELLHSLVEMKHXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFR 667
GCILCDELLHSL+EMKH DPKMSFR
Sbjct: 807 EGCILCDELLHSLIEMKHGKSFFMRRGRGRGRGRGRGRGSSHGRGRRGNSRHDDPKMSFR 866
Query: 668 DF 669
DF
Sbjct: 867 DF 868
>M8C938_AEGTA (tr|M8C938) DNA topoisomerase 3-beta-1 OS=Aegilops tauschii
GN=F775_05106 PE=4 SV=1
Length = 853
Score = 956 bits (2472), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 455/656 (69%), Positives = 513/656 (78%), Gaps = 4/656 (0%)
Query: 18 QTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMFQKLVA 77
TPTLGFCVQRY QINTFKPEKFWS+ YI+ G EIQLEW R KLFD +V MFQK+V
Sbjct: 198 NTPTLGFCVQRYQQINTFKPEKFWSLRTYIIKDGDEIQLEWDRKKLFDFDVTVMFQKMVP 257
Query: 78 EDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYPR 137
DG L++T+IS K+E K+RP GLNTVNLLKVASSALG GP AM +AERLY QG+ISYPR
Sbjct: 258 SDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHMAERLYIQGYISYPR 317
Query: 138 TESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAE 197
TESTAYP SFDFR LS A+NP W N V L+ G++KPR G DVGDHPPITPMR A E
Sbjct: 318 TESTAYPASFDFRSVLSTLAHNPLWSNNVRTLMDAGFVKPRQGHDVGDHPPITPMRLAPE 377
Query: 198 DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPW 257
+ L DAW+LYQYICQHFIGTVS DC Y R VEF+ GGE F C G V +KGFT+IMPW
Sbjct: 378 EALETDAWRLYQYICQHFIGTVSHDCIYTRTAVEFASGGEIFRCVGHRVTSKGFTSIMPW 437
Query: 258 LAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHIN 317
LA+ + N+P+F KG I + KV++YEG+TT PDYL+ESELISLMEKNGIGTDASIPVHIN
Sbjct: 438 LAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISLMEKNGIGTDASIPVHIN 497
Query: 318 NICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHH 377
NI ERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIAKG+ DH
Sbjct: 498 NISERNYVQVNSGRRLVPTALGTTLIRGYQCIDADLCLPDIRSFIEQQITLIAKGKADHL 557
Query: 378 RVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPS 437
+V+QH +QQF +K+ YFVKKIE MD LFEAQFS L DSGR+LSKCGKC RYMKYIS QP
Sbjct: 558 QVIQHSLQQFMRKYSYFVKKIENMDTLFEAQFSPLADSGRLLSKCGKCGRYMKYISTQPM 617
Query: 438 RLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYSNPPFE 496
R+YC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP CY++PPFE
Sbjct: 618 RMYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPCCYNSPPFE 677
Query: 497 GIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLDPVSAP 556
GI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVCACPECSGTL+LDPVSAP
Sbjct: 678 GIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGTLILDPVSAP 737
Query: 557 KWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCIL 616
KWRL CN CNC+V L AHRI+TT ++CP C+S+IIEVDFNKKATPLEDG+TLH GCIL
Sbjct: 738 KWRLLCNTCNCVVLLPHAAHRITTTDKKCPTCESTIIEVDFNKKATPLEDGATLHGGCIL 797
Query: 617 CDELLHSLVEMKHXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
CDELLHSLVEMKH DPKMSFRDF
Sbjct: 798 CDELLHSLVEMKHGKSFFMRRGRGRGRGRGRGRGGRGRGRRGNSRHDDPKMSFRDF 853
>M7YPL3_TRIUA (tr|M7YPL3) DNA topoisomerase 3-beta-1 OS=Triticum urartu
GN=TRIUR3_18494 PE=4 SV=1
Length = 870
Score = 904 bits (2335), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 431/630 (68%), Positives = 497/630 (78%), Gaps = 9/630 (1%)
Query: 1 MALFIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQR 60
+ L I LI V YGPCQTPTLGFCVQRY QINTFKPEKFWS+ YI+ G EIQLEW R
Sbjct: 232 LTLSINLI-VQVMYGPCQTPTLGFCVQRYQQINTFKPEKFWSLRAYIIKDGDEIQLEWDR 290
Query: 61 SKLFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMA 120
KLFD +V MFQK+VA DG L++T+IS K+E K+RP GLNTVNLLKVASSALG GP A
Sbjct: 291 KKLFDFDVTVMFQKMVASDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTA 350
Query: 121 MQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLG 180
M +AERLY QG+ISYPRTESTAYP SFDF+ LS A+NP W N V L+ G++KPR G
Sbjct: 351 MHMAERLYIQGYISYPRTESTAYPASFDFKSVLSTLAHNPLWSNNVRTLMDAGFVKPRQG 410
Query: 181 TDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFH 240
DVGDHPPITPMR A E+ L DAW+LYQYICQHFIGTVS DC+Y R VEF+ GGE F
Sbjct: 411 HDVGDHPPITPMRLAPEEALETDAWRLYQYICQHFIGTVSHDCRYTRTAVEFTSGGEIFR 470
Query: 241 CTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISL 300
C G V +KGFT+IMPWLA+ + N+P+F KG I + KV++YEG+TT PDYL+ESELISL
Sbjct: 471 CVGHRVTSKGFTSIMPWLAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISL 530
Query: 301 MEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRS 360
MEKNGIGTDASIPVHINNI ERNYVQV +GR+LVPT LG TL+RGYQ ID DLCLPDIRS
Sbjct: 531 MEKNGIGTDASIPVHINNISERNYVQVNSGRRLVPTALGTTLIRGYQCIDADLCLPDIRS 590
Query: 361 FIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILS 420
FIEQQITLIAKG+ DH +V+QHV+QQF +K+ YFVKKIE MD LFEAQFS L DSGR+LS
Sbjct: 591 FIEQQITLIAKGKADHLQVIQHVLQQFMRKYSYFVKKIENMDTLFEAQFSPLADSGRLLS 650
Query: 421 KCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPD 479
KC + ++ + + Y K + LYKE+ CPLD FELLL SM GPD
Sbjct: 651 KCA-----FSFFLIHCHIIFVLLPFVLLYFLSKTS--LYKEIICPLDGFELLLFSMVGPD 703
Query: 480 GKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVC 539
KSFPLCP CY++PPFEGI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVC
Sbjct: 704 AKSFPLCPCCYNSPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVC 763
Query: 540 ACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNK 599
ACPECSGTL+LDPVSAPKWRL CN CNC+V L AH+I+TT ++CP C+S+IIEVDFNK
Sbjct: 764 ACPECSGTLILDPVSAPKWRLLCNTCNCVVLLPHAAHKITTTDKKCPTCESTIIEVDFNK 823
Query: 600 KATPLEDGSTLHRGCILCDELLHSLVEMKH 629
KATPLEDG+TLH GCILCDELLHSLVEMKH
Sbjct: 824 KATPLEDGATLHEGCILCDELLHSLVEMKH 853
>M0V3B8_HORVD (tr|M0V3B8) Uncharacterized protein OS=Hordeum vulgare var.
distichum PE=3 SV=1
Length = 557
Score = 868 bits (2243), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 406/557 (72%), Positives = 462/557 (82%), Gaps = 1/557 (0%)
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MFQK+VA DG L++T+IS K+E K+RP GLNTVNLLKVASSALG GP AM +AERLY Q
Sbjct: 1 MFQKMVASDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHMAERLYIQ 60
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTESTAYP SFDFR LS A+NP W N V L+ G++KPR G DVGDHPPIT
Sbjct: 61 GYISYPRTESTAYPASFDFRSVLSTLAHNPLWSNNVRTLMDAGFVKPRQGHDVGDHPPIT 120
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PMR A E+ L DAW+LYQYICQHFIGTVS DC+Y R VEF+ GGE F C G V +KG
Sbjct: 121 PMRLAPEEALETDAWRLYQYICQHFIGTVSHDCRYTRTAVEFTSGGEIFRCVGHRVTSKG 180
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
FT+IMPWLA+ + N+P+F KG I + KV++YEG+TT PDYL+ESELISLMEKNGIGTDA
Sbjct: 181 FTSIMPWLAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISLMEKNGIGTDA 240
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIPVHINNI ERNYVQV GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIA
Sbjct: 241 SIPVHINNISERNYVQVNTGRRLVPTALGTTLIRGYQCIDADLCLPDIRSFIEQQITLIA 300
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
KG+ DH +V+QHV++QF +K+ YFVKKIE MD LFEAQFS L DSGR+LSKCGKC RYMK
Sbjct: 301 KGKADHLQVIQHVLEQFMRKYSYFVKKIENMDTLFEAQFSPLADSGRLLSKCGKCGRYMK 360
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYC 489
YIS QP R+YC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP C
Sbjct: 361 YISTQPMRMYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPCC 420
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLV 549
Y++PPFEGI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVCACPECSGTL+
Sbjct: 421 YNSPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGTLI 480
Query: 550 LDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGST 609
LDPVSAPKWRL CN CNC+V L AHRI+TT ++CP C+S+IIEVDFNKKATPLEDG+T
Sbjct: 481 LDPVSAPKWRLLCNTCNCVVLLPHAAHRITTTDKKCPTCESTIIEVDFNKKATPLEDGAT 540
Query: 610 LHRGCILCDELLHSLVE 626
LH GCILCDELLHSLVE
Sbjct: 541 LHEGCILCDELLHSLVE 557
>A9U3N3_PHYPA (tr|A9U3N3) DNA topoisomerase OS=Physcomitrella patens subsp.
patens GN=PHYPADRAFT_228008 PE=3 SV=1
Length = 869
Score = 866 bits (2238), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 412/669 (61%), Positives = 509/669 (76%), Gaps = 7/669 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+L+I TF P+ FW V P++ G+++ LEW R++LFD
Sbjct: 202 LDSSVISYGPCQTPTLGFCVERHLRITTFVPQPFWVVRPHLSKGGHQLMLEWDRNRLFDR 261
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
VA +FQKLV + + V ++ +K++ K+RP GLNTV++LKVASSAL GPH MQ+AER
Sbjct: 262 EVAMLFQKLVLDAKSVRVADVVKKEDRKTRPHGLNTVDMLKVASSALNMGPHHTMQIAER 321
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG++SYPRTESTAYP S+D R ALS N+P WG+Y L++ G P+ G DVGDH
Sbjct: 322 LYTQGYLSYPRTESTAYPASYDIREALSIHRNHPIWGDYASSLMSLGPHPPKSGVDVGDH 381
Query: 187 PPITPMRPAAEDMLGN-DAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
PPITP R A E LG D+W+LY+Y+ +HF+G+VSPDCKY R K+ F+ GGE F +G+
Sbjct: 382 PPITPTRSATESELGGGDSWRLYEYVTRHFLGSVSPDCKYTRTKITFTAGGEKFFASGRT 441
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
V + GFTA+MPWLA++D+++P G+ I ++ VELY+G T+ PDYLTESELI+LMEK+G
Sbjct: 442 VTSAGFTAVMPWLAVSDESLPLISAGELIPMTDVELYQGRTSAPDYLTESELITLMEKHG 501
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASI VHINNICERNY QVQ+GR+LVPT LGITLVRGYQ ID DLCLPDIR+FIE+Q
Sbjct: 502 IGTDASISVHINNICERNYAQVQSGRRLVPTPLGITLVRGYQVIDVDLCLPDIRAFIEKQ 561
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
ITLIAKGQ ++ RVV+HV+Q+F KF YFV +IE MD LFEAQFS L DSG+ LSKCGKC
Sbjct: 562 ITLIAKGQAEYSRVVRHVLQEFAAKFAYFVAQIEIMDTLFEAQFSPLADSGKPLSKCGKC 621
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFP 484
LRYMKYI+ +PSRLYC CEEV+ LPQ G IKLYKE++CPLDNFEL+L S+ GPDGKS+P
Sbjct: 622 LRYMKYIAMRPSRLYCPSCEEVHALPQNGHIKLYKEITCPLDNFELVLFSLAGPDGKSYP 681
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTS-GK-IGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
LCPYCY+NPPFEG E L S GK +GKG GMPC LCPHPTC NS++ QGVCACP
Sbjct: 682 LCPYCYNNPPFEGAEKLFGGVGFSKEPGKHVGKG-GMPCTLCPHPTCRNSMIQQGVCACP 740
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
EC GTLVLDPVSAPKWRL CN C+ LV+L AH+I+ +ERC EC S+++EV+FNK +T
Sbjct: 741 ECDGTLVLDPVSAPKWRLDCNKCSNLVYLPHNAHKIAVCQERCEECGSALLEVNFNKNST 800
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV-- 660
PL +G+TLH+ C+LCDELL+SLVE+KH
Sbjct: 801 PLSNGATLHKACLLCDELLYSLVEVKHGRSFFSRSGRGRGRGRGRGRGRRGRGRSRGRGE 860
Query: 661 DPKMSFRDF 669
DP+MSFRDF
Sbjct: 861 DPRMSFRDF 869
>M0V3B7_HORVD (tr|M0V3B7) Uncharacterized protein OS=Hordeum vulgare var.
distichum PE=3 SV=1
Length = 734
Score = 866 bits (2237), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 403/554 (72%), Positives = 456/554 (82%), Gaps = 1/554 (0%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCVQRY QINTFKPEKFWS+ YI+ G EIQLEW+R KLFD +V MF
Sbjct: 181 SYGPCQTPTLGFCVQRYQQINTFKPEKFWSLRTYIIKDGDEIQLEWERKKLFDFDVTVMF 240
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
QK+VA DG L++T+IS K+E K+RP GLNTVNLLKVASSALG GP AM +AERLY QG+
Sbjct: 241 QKMVASDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHMAERLYIQGY 300
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SFDFR LS A+NP W N V L+ G++KPR G DVGDHPPITPM
Sbjct: 301 ISYPRTESTAYPASFDFRSVLSTLAHNPLWSNNVRTLMDAGFVKPRQGHDVGDHPPITPM 360
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A E+ L DAW+LYQYICQHFIGTVS DC+Y R VEF+ GGE F C G V +KGFT
Sbjct: 361 RLAPEEALETDAWRLYQYICQHFIGTVSHDCRYTRTAVEFTSGGEIFRCVGHRVTSKGFT 420
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
+IMPWLA+ + N+P+F KG I + KV++YEG+TT PDYL+ESELISLMEKNGIGTDASI
Sbjct: 421 SIMPWLAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISLMEKNGIGTDASI 480
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
PVHINNI ERNYVQV GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIAKG
Sbjct: 481 PVHINNISERNYVQVNTGRRLVPTALGTTLIRGYQCIDADLCLPDIRSFIEQQITLIAKG 540
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
+ DH +V+QHV++QF +K+ YFVKKIE MD LFEAQFS L DSGR+LSKCGKC RYMKYI
Sbjct: 541 KADHLQVIQHVLEQFMRKYSYFVKKIENMDTLFEAQFSPLADSGRLLSKCGKCGRYMKYI 600
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYS 491
S QP R+YC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP CY+
Sbjct: 601 STQPMRMYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPCCYN 660
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLD 551
+PPFEGI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVCACPECSGTL+LD
Sbjct: 661 SPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGTLILD 720
Query: 552 PVSAPKWRLCCNMC 565
PVSAPKWRL CN C
Sbjct: 721 PVSAPKWRLLCNTC 734
>M1BDQ9_SOLTU (tr|M1BDQ9) DNA topoisomerase OS=Solanum tuberosum
GN=PGSC0003DMG402016626 PE=3 SV=1
Length = 547
Score = 857 bits (2213), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 406/550 (73%), Positives = 453/550 (82%), Gaps = 4/550 (0%)
Query: 121 MQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLG 180
MQLAERLYTQGFISYPRTESTAYP SFDF+G L A +NP +G Y + LLT Y KPR G
Sbjct: 1 MQLAERLYTQGFISYPRTESTAYPSSFDFKGTLGALVHNPVFGAYAQKLLTESYNKPRAG 60
Query: 181 TDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFH 240
TD GDHPPITPMR A+ED LGNDAWKLYQYICQHF+GT+SPDCKY R KVEF GGE F
Sbjct: 61 TDAGDHPPITPMRSASEDSLGNDAWKLYQYICQHFLGTLSPDCKYRRIKVEFESGGEQFQ 120
Query: 241 CTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISL 300
C GQ KGFT+IMPWLAI++KN+P F G+KIE+SK EL EG T+PPDYLTESELISL
Sbjct: 121 CVGQLATVKGFTSIMPWLAISEKNLPEFAVGEKIEISKAELDEGNTSPPDYLTESELISL 180
Query: 301 MEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRS 360
MEK+GIGTDASI VHINNICERNYVQVQAGR+L PT LGI+L+RGYQ ID DLCLPDIRS
Sbjct: 181 MEKHGIGTDASISVHINNICERNYVQVQAGRRLAPTPLGISLIRGYQCIDSDLCLPDIRS 240
Query: 361 FIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILS 420
FIE QITL+AKGQ DH VVQHV++QF++KF YFVK+I+ MDALFEAQFS L DSGR+LS
Sbjct: 241 FIEHQITLVAKGQADHSMVVQHVLEQFRRKFSYFVKQIDNMDALFEAQFSPLSDSGRLLS 300
Query: 421 KCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPD 479
KCGKCLRYMKYIS QP+RLYCG CEEVYY+PQKGT+KLYKEL+CPLDNFELLLCSM GP+
Sbjct: 301 KCGKCLRYMKYISTQPARLYCGTCEEVYYVPQKGTVKLYKELTCPLDNFELLLCSMPGPE 360
Query: 480 GKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVC 539
GKSFPLCPYC++ PPFEGI+ KT S K+GKG GMPC LCPH TCP+S+++QGVC
Sbjct: 361 GKSFPLCPYCFNCPPFEGIDTFFGAPKTGDSTKLGKGVGMPCFLCPHTTCPHSVIAQGVC 420
Query: 540 ACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNK 599
ACPECSGTLVLDPVSAPKWRL CNMCNCLV L +GAHRISTT+++CPECDS+IIEVDFNK
Sbjct: 421 ACPECSGTLVLDPVSAPKWRLYCNMCNCLVSLPEGAHRISTTQDKCPECDSTIIEVDFNK 480
Query: 600 KATPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXM 659
K TPL+DG+TLH+GCILCDELLHSLVEMKH
Sbjct: 481 KTTPLKDGATLHKGCILCDELLHSLVEMKHGRSFSRHGRRGRGRGRGRGRGRGSTKQQ-- 538
Query: 660 VDPKMSFRDF 669
DPKMSFRDF
Sbjct: 539 -DPKMSFRDF 547
>Q9SKZ9_ARATH (tr|Q9SKZ9) Putative DNA topoisomerase III beta OS=Arabidopsis
thaliana GN=At2g32000 PE=3 SV=1
Length = 836
Score = 855 bits (2208), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 418/668 (62%), Positives = 494/668 (73%), Gaps = 56/668 (8%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
+L+ VYF YGPCQTPTLGFCVQRY+ INTFKPEKFW++ PYI GYE+QLEW+R +LFD
Sbjct: 221 ILLNVYFRYGPCQTPTLGFCVQRYMHINTFKPEKFWALRPYIRKDGYELQLEWERRRLFD 280
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVAS--SALGFGPHMAMQL 123
+ AT+FQKLV E +V ++SEKQE K RP GLNTVNLLK + ++ G+ A+ +
Sbjct: 281 LEAATVFQKLVVEGRTAKVMDVSEKQEVKGRPAGLNTVNLLKCSRVWASDGYASCRAI-V 339
Query: 124 AERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDV 183
R + G T++ +PP R A
Sbjct: 340 YSRFHQSG------TDAGDHPPITPMRAA------------------------------- 362
Query: 184 GDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTG 243
E M+G DAW+LYQY+CQHF+GTVSP+CKY R KVE SIGGE+FHCTG
Sbjct: 363 ------------TEVMVGGDAWRLYQYVCQHFLGTVSPNCKYIRTKVELSIGGETFHCTG 410
Query: 244 QHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
Q V KGFTAIMPW A+++K +PSF+KG++IEV +VELYEG T PPDYLTESELISLMEK
Sbjct: 411 QRVTEKGFTAIMPWSAVDEKKLPSFLKGERIEVLRVELYEGNTAPPDYLTESELISLMEK 470
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASI VHINNI ERNYVQVQ+GRK+VPT LGITL+RGYQ IDPDLCLPDIRSFIE
Sbjct: 471 HGIGTDASIAVHINNIGERNYVQVQSGRKMVPTALGITLIRGYQCIDPDLCLPDIRSFIE 530
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
QQITL+AKGQ DH VVQHVIQQF++KF YFV++IE MDALFEAQFS L DSGR LSKCG
Sbjct: 531 QQITLVAKGQADHSHVVQHVIQQFRRKFSYFVQQIEHMDALFEAQFSPLADSGRALSKCG 590
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKS 482
KCLRYMK+I+A P RL+CG CEEVYYLPQKGT+KLYKEL+CPLDNFEL++ S+ GP+GKS
Sbjct: 591 KCLRYMKHITAVPPRLFCGTCEEVYYLPQKGTVKLYKELTCPLDNFELVIYSVPGPEGKS 650
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTS-GKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
FPLCPYCY++PPFEGI+ L +KT + K GAGMPC LCPHPTC +S+ +QGVCAC
Sbjct: 651 FPLCPYCYNSPPFEGIDTLFGASKTPNAPAKTKTGAGMPCSLCPHPTCQHSVRNQGVCAC 710
Query: 542 PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKA 601
PEC GTLVLDPVS PKW+L CN+C+C+V L +GAHRI+TT RCPECDS+IIE+DFNKK
Sbjct: 711 PECEGTLVLDPVSFPKWKLNCNLCSCIVLLPEGAHRITTTSNRCPECDSAIIEIDFNKKT 770
Query: 602 TPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVD 661
TPLE+G+TLH+GC+LCDELL SLVE+KH VD
Sbjct: 771 TPLENGATLHQGCVLCDELLLSLVEVKHGRSFVRRGGRGRGRGRGRGRGGRRGSKS--VD 828
Query: 662 PKMSFRDF 669
PKMSFRDF
Sbjct: 829 PKMSFRDF 836
>D8S3T9_SELML (tr|D8S3T9) Putative uncharacterized protein OS=Selaginella
moellendorffii GN=SELMODRAFT_233065 PE=3 SV=1
Length = 877
Score = 830 bits (2144), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 396/670 (59%), Positives = 493/670 (73%), Gaps = 10/670 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + S+GPCQTPTLGFCV+R+ QI TF P+ FW+++P + G+ +QL+W+R ++F+
Sbjct: 211 LDSSVISFGPCQTPTLGFCVERHTQIITFVPKPFWTLHPRLSKGGHSLQLDWERGRVFEQ 270
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
A + QK V + G L+V ++S+K+E K+RP GLNTVN+LKVAS+ALG GPH AMQ+AER
Sbjct: 271 ATALVPQKAVLKSGSLKVLDVSQKEERKARPTGLNTVNMLKVASTALGMGPHHAMQIAER 330
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY QG+ISYPRTESTAYP SFD + +L N+P +G+Y L+ G P+ GTD GDH
Sbjct: 331 LYVQGYISYPRTESTAYPASFDVKESLLPLGNHPVFGDYARSLIAAGVRAPKSGTDAGDH 390
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR E LG DAW+LY YI +HF+G+VSPDCKY R KV FS GGE F C+G+ V
Sbjct: 391 PPITPMRSGTESELGGDAWRLYDYISRHFLGSVSPDCKYKRTKVTFSGGGEVFTCSGKVV 450
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
+ GFT MPW+A+ D+N+P+F G+ + S+VELY+G T+PPDYLTES+LISLMEK+GI
Sbjct: 451 TSPGFTIAMPWMAVTDENLPAFTIGESLPCSEVELYQGRTSPPDYLTESDLISLMEKHGI 510
Query: 307 GTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQI 366
GTDASIPVHINNIC+RNYVQVQ GR+LVPT LGITL+RGYQ+ID DLCLPDIRSFIEQQI
Sbjct: 511 GTDASIPVHINNICQRNYVQVQTGRRLVPTALGITLIRGYQTIDADLCLPDIRSFIEQQI 570
Query: 367 TLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCL 426
TLIAKGQ+DH VV++ + +F KF F IE MDALFEA FS L DSGR LSKCGKC
Sbjct: 571 TLIAKGQVDHETVVRNSLDKFVAKFKNF---IEKMDALFEAHFSPLADSGRPLSKCGKCK 627
Query: 427 RYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPL 485
RYMKYI+ +PSRLYC CEEVY +PQ G+IKLYKEL+CPLDNFEL+L S+ GPDGKS+PL
Sbjct: 628 RYMKYITLRPSRLYCSTCEEVYPVPQNGSIKLYKELACPLDNFELVLFSLGGPDGKSYPL 687
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS 545
CPYCY++P + A TS+ + GAGMPC +CPH TC +S++ QGVCACPEC
Sbjct: 688 CPYCYNHPLESPARDPSSEATTSSDDQATTGAGMPCTMCPHATCRHSVMQQGVCACPECD 747
Query: 546 GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTK-ERCPECDSSIIEVDFNKKATPL 604
GTL+LDP+SAPKWRL CN C+ LV+L H++S ++ + C +C S+++EVDF+K TPL
Sbjct: 748 GTLILDPISAPKWRLDCNKCSFLVYLPANTHKVSRSEHDYCDDCGSALLEVDFHKNNTPL 807
Query: 605 EDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV---- 660
E G TLH C++CDELL SLV MKH
Sbjct: 808 EGGRTLHTACVVCDELLQSLVVMKHGKSFGRSRGRGRGRGRGRGRGRGRGGGRGGGRGKH 867
Query: 661 -DPKMSFRDF 669
DP+MSFRDF
Sbjct: 868 QDPRMSFRDF 877
>D8R567_SELML (tr|D8R567) Putative uncharacterized protein OS=Selaginella
moellendorffii GN=SELMODRAFT_168492 PE=3 SV=1
Length = 871
Score = 822 bits (2123), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 397/689 (57%), Positives = 494/689 (71%), Gaps = 29/689 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + S+GPCQTPTLGFCV+R+ QI TF P+ FW+++P + G+ +QL+W+R ++F+
Sbjct: 186 LDSSVISFGPCQTPTLGFCVERHTQIITFVPKPFWTLHPRLSKGGHSLQLDWERGRVFEQ 245
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
A + QK V + G L+V ++S+K+E K+RP GLNTVN+LKVAS+ALG GPH AMQ+AER
Sbjct: 246 ATALVPQKAVLKSGSLKVLDVSQKEERKARPTGLNTVNMLKVASTALGMGPHHAMQIAER 305
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY QG+ISYPRTESTAYP SFD + +L N+P +G+Y L+ G P+ GTD GDH
Sbjct: 306 LYVQGYISYPRTESTAYPASFDVKESLLPLGNHPVFGDYARSLIAAGVRAPKSGTDAGDH 365
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR E LG DAW+LY YI +HF+G+VSPDCKY R KV FS GGE F C+G+ V
Sbjct: 366 PPITPMRSGTESELGGDAWRLYDYISRHFLGSVSPDCKYKRTKVTFSGGGEVFTCSGKVV 425
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
+ GFT MPW+A+ D+N+P+F G+ + S+VELY+G T+PPDYLTES+LISLMEK+GI
Sbjct: 426 TSPGFTIAMPWMAVTDENLPAFTIGESLPCSEVELYQGRTSPPDYLTESDLISLMEKHGI 485
Query: 307 GTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQI 366
GTDASIPVHINNIC+RNYVQVQ GR+LVPT LGITL+RGYQ+ID DLCLPDIRSFIEQQI
Sbjct: 486 GTDASIPVHINNICQRNYVQVQTGRRLVPTALGITLIRGYQTIDADLCLPDIRSFIEQQI 545
Query: 367 TLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCL 426
TLIAKGQ+DH VV++ + +F KF F IE MDALFEA FS L DSGR LSKCGKC
Sbjct: 546 TLIAKGQVDHETVVRNSLDKFVAKFKNF---IEKMDALFEAHFSPLADSGRPLSKCGKCK 602
Query: 427 RYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPL 485
RYMKYI+ +PSRLYC CEEVY +PQ G+IKLYKEL+CPLDNFEL+L S+ GPDGKS+PL
Sbjct: 603 RYMKYITLRPSRLYCSTCEEVYPVPQNGSIKLYKELACPLDNFELVLFSLGGPDGKSYPL 662
Query: 486 CPYCYSNPPFEGIEALINTAKTSTS-----------------GKIGKGAGMPCILCPHPT 528
CPYCY++P + A TS+ G+ GAGMPC +CPH T
Sbjct: 663 CPYCYNHPLESPARDPSSEATTSSDDQASGTAPGDGNPNTRRGRAATGAGMPCTMCPHAT 722
Query: 529 CPNSLVSQGVCACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTK-ERCPE 587
C +S++ QGVCACPEC GTL+LDP+SAPKWRL CN C+ LV+L H++S ++ + C +
Sbjct: 723 CRHSVMQQGVCACPECDGTLILDPISAPKWRLDCNKCSFLVYLPANTHKVSRSEHDYCDD 782
Query: 588 CDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXX 647
C S+++EVDF+K TPLE G TLH C++CDELL SLV MKH
Sbjct: 783 CGSALLEVDFHKNNTPLEGGRTLHTACVVCDELLQSLVVMKHGKSFGRSRGRGRGRGRGR 842
Query: 648 XXXXXXXXXXXMV-------DPKMSFRDF 669
DP+MSFRDF
Sbjct: 843 GRGRGRGRGGGRGGGRGKHQDPRMSFRDF 871
>A7RW77_NEMVE (tr|A7RW77) DNA topoisomerase OS=Nematostella vectensis
GN=v1g182679 PE=3 SV=1
Length = 856
Score = 725 bits (1871), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 348/626 (55%), Positives = 443/626 (70%), Gaps = 21/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFD 65
L + SYGPCQTPTLGFCV+R+ QI +FKPE +W + P +VHS G + L+W R ++FD
Sbjct: 205 LDSALISYGPCQTPTLGFCVERHDQIQSFKPEAYWVIKPKVVHSSGQSVVLDWDRVRVFD 264
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A +FQK + E +VT IS+ Q+TK RP LNTV +L++ASS LG GP MQ+AE
Sbjct: 265 KEIALVFQKTIKESSNAQVTCISKTQKTKQRPQALNTVEMLRLASSGLGMGPQHTMQIAE 324
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +GAL Q+ + WG++V LL KPR G D GD
Sbjct: 325 RLYTQGYISYPRTETTHYPENFDLKGALKQQSGSAMWGSHVRELLDGAMTKPRKGHDAGD 384
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+E LG D W+LY +I +HF+ T+SPDCKY + V+F IG E+F TG+
Sbjct: 385 HPPITPMRCASESELGGDPWRLYDFITRHFLATLSPDCKYLQTTVKFKIGKEAFSFTGKA 444
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT++M W AI +D+ +P F KG +V++V+L E T PPD+LTESELI+LMEK+
Sbjct: 445 VTDPGFTSVMTWQAISDDERMPPFNKGDICQVAEVKLDERQTLPPDFLTESELITLMEKH 504
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI VHINNICERNYVQ+Q+GRKL PT+LGI LV GYQ IDP+L LP +RS +E+
Sbjct: 505 GIGTDASISVHINNICERNYVQIQSGRKLAPTSLGIVLVHGYQKIDPELVLPTMRSAVEE 564
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA G+ D + V+ H I F QKF YFVK + +MD LFE F+ L +SG+ LS+CGK
Sbjct: 565 QLNLIAHGKADFNAVLHHAIGIFTQKFTYFVKTVSSMDELFEVSFTPLSESGKPLSRCGK 624
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYMKYI+A+PSRL+C C+E Y LPQ G+IKLYKEL CPLD+FEL+L S G GKS P
Sbjct: 625 CNRYMKYIAAKPSRLHCATCDETYSLPQNGSIKLYKELRCPLDDFELVLWSTGAKGKSTP 684
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
+CPYCYS+PPF + GM C C HPTCP+S + GV C EC
Sbjct: 685 VCPYCYSHPPFPTMR-----------------KGMGCNQCTHPTCPHSEEALGVADCLEC 727
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G L LDP SAPKWRL CNMCN ++ + +GA RIS +++ C +C SS ++VDFNK +P
Sbjct: 728 EKGMLNLDPTSAPKWRLACNMCNVVIHMCEGAFRISLSEDEC-DCGSSKLDVDFNKANSP 786
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L + T HRGC CD +L LV ++H
Sbjct: 787 LPNNLTQHRGCPFCDPILVPLVRLQH 812
>H3IS98_STRPU (tr|H3IS98) Uncharacterized protein OS=Strongylocentrotus
purpuratus PE=3 SV=1
Length = 725
Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 345/626 (55%), Positives = 441/626 (70%), Gaps = 21/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFD 65
L + SYGPCQTPTLGFCV R+ +I +FKPE FW + + H SG ++ L+W R ++FD
Sbjct: 71 LDSTLISYGPCQTPTLGFCVNRHDKIQSFKPEPFWVIQIQVTHESGRKLNLDWDRVRVFD 130
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA MF ++ +T +S+K++ K RP LNTV L++VASS+LG PH AMQ+AE
Sbjct: 131 REVAQMFLNIIKTQKDARITSVSQKEKAKQRPQALNTVELMRVASSSLGMSPHHAMQIAE 190
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLY QG+ISYPRTE+T+YP SFD +G L Q + P W + V+ LL + KPR GTDVGD
Sbjct: 191 RLYIQGYISYPRTETTSYPESFDLKGTLRQQMSAP-WRSEVKVLLDGEFTKPRKGTDVGD 249
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E +G +AW+LY+YI +HFI TVSPDC+Y + IG E F CTG+
Sbjct: 250 HPPITPMRAANESEVGGEAWRLYEYIARHFIATVSPDCRYLLTTIRLMIGEEGFSCTGKT 309
Query: 246 VITKGFTAIMPWLAINDK-NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I+ GFTA+MPW AI D+ N+P+ KG + + +L E T+PPDYLTESELISLMEK+
Sbjct: 310 LISDGFTAVMPWQAIQDEENLPNVTKGDMCSIEEAKLSERQTSPPDYLTESELISLMEKH 369
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
G+GTDASIPVHI NIC+RNYV+V++GR+LVPT LGI LV GYQ IDPDL LP +RS +E+
Sbjct: 370 GVGTDASIPVHIENICQRNYVKVESGRRLVPTRLGIVLVHGYQKIDPDLSLPTMRSAVEE 429
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA GQ D + V+ H I F +KF YFV I+AMD LFE FS L +G+ +S+CGK
Sbjct: 430 QLNLIAHGQADFNSVLIHTIDIFTRKFLYFVDHIQAMDDLFEVSFSPLAATGKPMSRCGK 489
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYISA+P RL+C CEE Y LPQ G+IKLYKE+ CPLD+FEL+L S GP GKS+P
Sbjct: 490 CHRFMKYISAKPMRLHCPTCEETYSLPQNGSIKLYKEIRCPLDDFELVLWSSGPKGKSYP 549
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
+CPYC+S+PPF T K G+G C C HPTC +SL GV C EC
Sbjct: 550 VCPYCFSHPPF-------------TEMKKGQG----CNGCTHPTCAHSLTMLGVAQCIEC 592
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G +VLDP SAPKWRL CN CN ++ + + AH+++ + C +CD+SI+ V+FNK TP
Sbjct: 593 DEGVMVLDPSSAPKWRLACNKCNIIMNIFEDAHKVTLSGHLCEKCDASILNVNFNKNKTP 652
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
LE G T H+GCI CD +L L E +H
Sbjct: 653 LEGGETYHKGCIFCDPILTPLTEAQH 678
>R7VCK8_9ANNE (tr|R7VCK8) Uncharacterized protein OS=Capitella teleta
GN=CAPTEDRAFT_182010 PE=4 SV=1
Length = 856
Score = 715 bits (1845), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 336/626 (53%), Positives = 431/626 (68%), Gaps = 21/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFD 65
L + SYGPCQTPTLGFCV R+ +I +FKPE FW + +VH SG + L+W+R ++FD
Sbjct: 202 LDSTLISYGPCQTPTLGFCVDRHDRIQSFKPETFWVIQMQVVHPSGKMMSLDWERVRIFD 261
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA MF ++ + + ++ +K+++K+RP+ LNTV +L+ ASS LG GP M +AE
Sbjct: 262 NEVARMFLSMIKANDKAVIVDVQKKEKSKARPMALNTVEMLRTASSGLGIGPSTCMMIAE 321
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L Q NN WG V+ LL G KP+ G+D GD
Sbjct: 322 RLYTQGYISYPRTETTHYPENFDLKGTLRIQQNNHEWGAEVKALLNEGIQKPKKGSDAGD 381
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG+DAW+LY +I +HFIGT+SPDCKY + + F +G E F CTG+
Sbjct: 382 HPPITPMRSATEAELGHDAWRLYSFITRHFIGTISPDCKYLQTTISFKVGNEEFSCTGKT 441
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I+ GFT++M W A+ D+N+P G+K E+S V+L E T+PPDYLTE+ELI+LMEK+
Sbjct: 442 LISAGFTSVMTWQALAADENLPKCTVGEKCEISNVKLAERQTSPPDYLTEAELITLMEKH 501
Query: 305 GIGTDASIPVHINNICERNYVQVQA-GRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
GIGTDASIPVHINNICERNYV V A GRKL PTTLGI LV GY ID DL P +R+ +E
Sbjct: 502 GIGTDASIPVHINNICERNYVNVTATGRKLKPTTLGIVLVHGYVKIDADLIKPTMRAAVE 561
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
QQ+ LIA+G+ D + V+QH I FK+KF YFV+ I +MD LFE FS L DSG+ +S+CG
Sbjct: 562 QQLNLIAQGKADFNAVLQHAIDIFKRKFKYFVENINSMDELFEVSFSPLADSGKPMSRCG 621
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC RYMKY+ A+PSRL+C C++ Y LPQ G IK+YKEL CPLD+FEL+ + GP+ K F
Sbjct: 622 KCRRYMKYVQAKPSRLHCSSCDDTYSLPQNGNIKIYKELKCPLDDFELIYWTAGPNTKGF 681
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
P CPYCY+N PF ++ GM C C HPTC N+ GV AC E
Sbjct: 682 PFCPYCYNNSPFHDMK-----------------KGMGCNECTHPTCGNAFGQTGVSACVE 724
Query: 544 CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
C G LVLDP+S PKW++ CN CN + L A + T E C EC S+II++ F K +P
Sbjct: 725 CGGVLVLDPLSGPKWKVACNKCNVMFNLFDSAKNVEVTDETCEECQSAIIDIQFKNK-SP 783
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
LE GS + GC+ CD L LV MKH
Sbjct: 784 LESGSMQYTGCLFCDPQLKPLVRMKH 809
>I0YWU4_9CHLO (tr|I0YWU4) DNA topoisomerase OS=Coccomyxa subellipsoidea C-169
GN=COCSUDRAFT_16360 PE=3 SV=1
Length = 866
Score = 704 bits (1816), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 345/669 (51%), Positives = 447/669 (66%), Gaps = 13/669 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQR+ I F+PE +W++ P + I +EW R +LFD
Sbjct: 205 LDASVISYGPCQTPTLFFCVQRHQLITAFQPEDYWTIRPNCGVCVFRIDVEWSRGRLFDR 264
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+VA +FQ++V E L E+S K+E + RP GLNTV L+K ASSA+G P AM+ AE
Sbjct: 265 DVALLFQRIVTEARALRCVEVSAKEERRQRPNGLNTVELMKTASSAMGMSPQQAMRCAEG 324
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNG-YLKPRLGTDVGD 185
LYT G+ISYPRTESTAYPP FDF L +P WG Y GL+ +G + P+ G D GD
Sbjct: 325 LYTSGYISYPRTESTAYPPGFDFHEVLVEMRRHPIWGEYAAGLMGHGAFAPPKGGHDAGD 384
Query: 186 HPPITPMRPAAEDMLGN-DAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPITP+ A E LG D W+LY YI +HF+G++SPDC R F+ G E F TG
Sbjct: 385 HPPITPIASATEAELGGGDDWRLYDYIARHFLGSLSPDCVLRRTTAAFAAGNERFSATGV 444
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+ GFTA+MPW A+ + +P +G+ + +++VEL +G T+PPDYLTESELI LMEK+
Sbjct: 445 APVRAGFTAVMPWKAVQGEPLPPLHEGEILPITEVELKQGKTSPPDYLTESELIGLMEKH 504
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI VHI +CER YV +Q+GR+L+PT LG+TLVRGYQ IDPDLCLP +RS +E+
Sbjct: 505 GIGTDASISVHIAKVCER-YVSIQSGRRLMPTELGVTLVRGYQLIDPDLCLPLVRSHVEK 563
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
QI LIA+G VV H + QF +KF YFV KIE MDALFEA FS L SG+ LSKCGK
Sbjct: 564 QIDLIAQGLAGREAVVAHTLDQFSRKFRYFVGKIERMDALFEASFSPLASSGKPLSKCGK 623
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSF 483
C RYMK IS +PSR+YC CEEV LPQ G++KLYK L+CPLDN+E++L S+ GPD K++
Sbjct: 624 CARYMKLISVRPSRMYCPTCEEVLNLPQGGSVKLYKGLACPLDNYEIVLFSLTGPDAKTY 683
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGA--GMPCILCPHPTCPNSLVSQGVCAC 541
PLCP+CY+NPP ++ ++ + +G G GA GMPC LCPH C +S + +GV C
Sbjct: 684 PLCPFCYNNPPAGAMQNDGSSMRRQVAGP-GAGAKPGMPCTLCPHMGCQHSFLRKGVTPC 742
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
PEC +GT+VLDPVS PKWRL CN+C+ +++L + H + +KERC EC+S ++++DF K
Sbjct: 743 PECDTGTVVLDPVSGPKWRLDCNLCSFMIYLPETLHAVKLSKERCQECESVLLKLDFKKG 802
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV 660
A+PL +G T C++C+E + +L KH
Sbjct: 803 ASPLPNGETETTACVVCNEKIAALCTAKHGRSYAKRRGGGRRGRGRGRGRGRRTG----- 857
Query: 661 DPKMSFRDF 669
DP MSFRDF
Sbjct: 858 DPLMSFRDF 866
>F1QNX4_DANRE (tr|F1QNX4) DNA topoisomerase OS=Danio rerio GN=top3b PE=3 SV=1
Length = 862
Score = 703 bits (1815), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 326/627 (51%), Positives = 430/627 (68%), Gaps = 21/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W V + + G + + L+W R ++F
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPEAYWVVQAKVANFGKDSPLTLDWDRVRVF 266
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D ++ MF + V +++K++ K RP+ LNTV +L+VASSALG GP MQ+A
Sbjct: 267 DRDIGQMFVNMAKTAKEARVDSVTKKEKAKQRPLALNTVEMLRVASSALGMGPQHTMQIA 326
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G L QAN+ WG V+ LL+ G +PR G D G
Sbjct: 327 ERLYTQGYISYPRTETTHYPENFDLKGTLKQQANSTFWGETVKALLSEGINRPRKGADAG 386
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPMR A+E+ LG+D W+LY YI +HFI TVSPDCKY + + FSI E F C+G+
Sbjct: 387 DHPPITPMRAASENELGSDGWRLYDYITRHFIATVSPDCKYLQTTISFSIATEGFTCSGK 446
Query: 245 HVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+I+ G+T +MPW I ++ +P +G+ V +++L E T PPDYLTE+ELI+LMEK
Sbjct: 447 TLISAGYTEVMPWQGIAQEEALPVCERGEMFTVDEIKLLEKQTNPPDYLTEAELITLMEK 506
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V++GRKL PT LGI LV GY ID DL LP IRS +E
Sbjct: 507 HGIGTDASIPVHINNICQRNYVTVESGRKLKPTNLGIVLVHGYYKIDADLVLPTIRSAVE 566
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+TLIA G+ + +V+QH + FK+KF YFV I MD L E FS + +G+ LS+CG
Sbjct: 567 KQLTLIALGKANFQQVLQHTLDIFKRKFHYFVDSIAGMDELMEVSFSPIAATGKPLSRCG 626
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL CPLD FEL+L + G GKS+
Sbjct: 627 KCHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELKCPLDEFELVLWTSGSRGKSY 686
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
P+CPYC+SNPPF ++ GM C C HP+C +SL S G+ C E
Sbjct: 687 PVCPYCFSNPPFRDMK-----------------KGMGCNECTHPSCQHSLNSLGIGQCVE 729
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C +G LV DP S PKWR+ CN CN +V + AH++ +++ C C++S++ VDFNK +
Sbjct: 730 CETGVLVFDPTSGPKWRMACNKCNVVVHFFEQAHKVQVSQDSCDSCEASLVIVDFNKTRS 789
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL DG T H GC+ CD LVE+KH
Sbjct: 790 PLPDGETQHTGCVFCDSAFQDLVELKH 816
>M0V3B5_HORVD (tr|M0V3B5) Uncharacterized protein OS=Hordeum vulgare var.
distichum PE=3 SV=1
Length = 460
Score = 703 bits (1814), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/460 (71%), Positives = 376/460 (81%), Gaps = 1/460 (0%)
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MFQK+VA DG L++T+IS K+E K+RP GLNTVNLLKVASSALG GP AM +AERLY Q
Sbjct: 1 MFQKMVASDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHMAERLYIQ 60
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTESTAYP SFDFR LS A+NP W N V L+ G++KPR G DVGDHPPIT
Sbjct: 61 GYISYPRTESTAYPASFDFRSVLSTLAHNPLWSNNVRTLMDAGFVKPRQGHDVGDHPPIT 120
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PMR A E+ L DAW+LYQYICQHFIGTVS DC+Y R VEF+ GGE F C G V +KG
Sbjct: 121 PMRLAPEEALETDAWRLYQYICQHFIGTVSHDCRYTRTAVEFTSGGEIFRCVGHRVTSKG 180
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
FT+IMPWLA+ + N+P+F KG I + KV++YEG+TT PDYL+ESELISLMEKNGIGTDA
Sbjct: 181 FTSIMPWLAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISLMEKNGIGTDA 240
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIPVHINNI ERNYVQV GR+LVPT LG TL+RGYQ ID DLCLPDIRSFIEQQITLIA
Sbjct: 241 SIPVHINNISERNYVQVNTGRRLVPTALGTTLIRGYQCIDADLCLPDIRSFIEQQITLIA 300
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
KG+ DH +V+QHV++QF +K+ YFVKKIE MD LFEAQFS L DSGR+LSKCGKC RYMK
Sbjct: 301 KGKADHLQVIQHVLEQFMRKYSYFVKKIENMDTLFEAQFSPLADSGRLLSKCGKCGRYMK 360
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYC 489
YIS QP R+YC CEEVYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP C
Sbjct: 361 YISTQPMRMYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPCC 420
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTC 529
Y++PPFEGI+ L K +GK+GKGAGMPC LCPHPTC
Sbjct: 421 YNSPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTC 460
>H9G5D6_ANOCA (tr|H9G5D6) DNA topoisomerase OS=Anolis carolinensis GN=top3b PE=3
SV=1
Length = 862
Score = 701 bits (1809), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/626 (52%), Positives = 433/626 (69%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE-IQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + H + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPEMYWVLQAKVSHEKDSCLTLDWDRVRIFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A +F + +V +S K+++K RP+ LNTV +L+VAS+ALG GP AMQ+AE
Sbjct: 267 REIAQLFLNITKAVKDAKVESVSRKEKSKQRPLALNTVEMLRVASAALGMGPQHAMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QANNP W V+ LL G KPR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANNPYWAETVKALLAEGINKPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+E LG D W+L++YI +HFI TVS DCKY + + S+G E F C G+
Sbjct: 387 HPPITPMRAASEAELGGDGWRLFEYITRHFIATVSADCKYLQTTITCSVGTERFTCIGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI GFT IMPW +I ++++PS +G VS+++L E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VILPGFTEIMPWQSIPPEESLPSCERGDVFPVSEIKLLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V+ GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLNMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
+G LVLDP+S PKW++ CN CN +V + AH++ + E C CD+++++VDFNK +P
Sbjct: 730 ENGVLVLDPISGPKWKMACNKCNVVVHFFENAHKVRVSAETCEGCDAALVDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L G T H GC+ CD + LVE+KH
Sbjct: 790 LPGGETQHSGCVFCDPVFQDLVELKH 815
>I3JWA9_ORENI (tr|I3JWA9) DNA topoisomerase OS=Oreochromis niloticus GN=top3b
PE=3 SV=1
Length = 856
Score = 701 bits (1808), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 335/627 (53%), Positives = 431/627 (68%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + V G E + L+W R ++F
Sbjct: 205 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVIQTK-VFKGKESPLTLDWNRVRVF 263
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D V MF L +V +S+K++TK RP LNTV +L+VASSALG GP MQ+A
Sbjct: 264 DREVGQMFVNLAKTSREAQVELVSKKEKTKQRPQALNTVEMLRVASSALGMGPQHTMQIA 323
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G L Q NNP W V+ LL+ G +PR GTD G
Sbjct: 324 ERLYTQGYISYPRTETTHYPVNFDLKGTLKQQTNNPFWAEEVKVLLSTGINQPRKGTDAG 383
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPM A E LG+D+W+LY+YI +HFI TVS DCKY + +EFSIG E+F C+G+
Sbjct: 384 DHPPITPMCAATEAELGSDSWRLYEYITRHFIATVSQDCKYLQTTIEFSIGTEAFSCSGR 443
Query: 245 HVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+I+ G+T +MPW I +++IP G V +++L E T+PPDYLTE+ELI+LMEK
Sbjct: 444 TLISPGYTTVMPWQGIPLEESIPVCEHGDTFSVDEIKLIEKQTSPPDYLTEAELITLMEK 503
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V++GRKL PT LGI LV GY ID +L LP IRS +E
Sbjct: 504 HGIGTDASIPVHINNICQRNYVTVESGRKLKPTNLGIVLVHGYYKIDAELVLPTIRSAVE 563
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ ++ +V+QH + FK+KF YFV I MD L E FS + +G+ LS+CG
Sbjct: 564 KQLNLIAQGKANYQQVLQHALDIFKRKFHYFVDSITNMDELMEVSFSPIAATGKPLSRCG 623
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL CPLD+FEL+L + G GKS+
Sbjct: 624 KCHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELRCPLDDFELVLWTSGARGKSY 683
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYC+SNPPF ++ GM C C HP+C +SL S G+ C E
Sbjct: 684 PLCPYCFSNPPFRDMK-----------------KGMGCNECTHPSCQHSLNSLGIGQCVE 726
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C SG LVLDP S PKWR+ CN CN +V + AH++ +E C CD+S++ VDFNK T
Sbjct: 727 CDSGVLVLDPTSGPKWRMACNKCNVVVHFFEHAHKVQVAQESCDVCDASLVAVDFNKTRT 786
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL T H GC+ CD + LVE+KH
Sbjct: 787 PLPASETQHTGCVFCDPVFQDLVELKH 813
>E1ZIK6_CHLVA (tr|E1ZIK6) DNA topoisomerase OS=Chlorella variabilis
GN=CHLNCDRAFT_53167 PE=3 SV=1
Length = 860
Score = 700 bits (1806), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 341/671 (50%), Positives = 443/671 (66%), Gaps = 25/671 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTL FCV+R+ I +F+PE FW V P +G+ + LEW R ++FD
Sbjct: 207 LDSAVISYGPCQTPTLNFCVERHQAIVSFQPEPFWVVRPRASQAGHALNLEWGRGRVFDG 266
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
V +FQ+LV E +V+ I + + P L V LLK ASS+LG GP AMQ+AER
Sbjct: 267 EVGAVFQRLVHEAK--QVSMILTPVDPRDPPC-LCAVELLKTASSSLGIGPAYAMQVAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG++SYPRTESTAYPP+FDF L+AQ +P WG Y L+ + P+ G DVGDH
Sbjct: 324 LYTQGYLSYPRTESTAYPPNFDFHTLLAAQRAHPVWGEYAASLM-GAFAAPKGGVDVGDH 382
Query: 187 PPITPMRPAAEDMLGN-DAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
PPITP+R A+E LG D W+LY ++ +HF+G++SPDC + + + G ESF +G
Sbjct: 383 PPITPVRCASEAELGGGDTWRLYDFVARHFLGSLSPDCVVRKTRASLAAGTESFAASGTL 442
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
V+ G+ AIMPW A+ ++ +P G I +S+VEL++G T+PPDYLTE+ELI MEK+G
Sbjct: 443 VLRPGYAAIMPWKAVQNEPLPPMKAGDTIPMSEVELHQGKTSPPDYLTEAELIERMEKHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIP HINNICERNYV +Q+GR++VPT LGITLVRGYQ IDP+LC P +R+ +E Q
Sbjct: 503 IGTDASIPTHINNICERNYVSIQSGRRVVPTELGITLVRGYQLIDPELCRPQVRAHVEHQ 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ L+AKGQ D VV H +++F+QKF +FV I+ MDALFEA FS L SG++LSKCGKC
Sbjct: 563 LDLVAKGQADKEAVVAHCLEEFRQKFAFFVAHIQRMDALFEASFSPLASSGKVLSKCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFP 484
R+M+ I+++PSRLYCG CEEVY +PQ G IKLYKELSCPLD F+LLL S+ G DGK+
Sbjct: 623 NRFMRLIASRPSRLYCGTCEEVYSMPQGGAIKLYKELSCPLDGFQLLLFSLGGADGKNTV 682
Query: 485 LCPYCYSNPPF-EGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
LCPYCY++PPF EG+E G AGMPC C HP C +S GV ACP
Sbjct: 683 LCPYCYNHPPFLEGVEQ-------------GGRAGMPCSQCAHPACRHSPARMGVAACPA 729
Query: 544 CS-----GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFN 598
C G LVLDPV +P WRL C+ C+ L+ L + H + C EC + +++VD+
Sbjct: 730 CEGEQQQGMLVLDPVGSPSWRLDCSRCSFLIVLPKNLHSAKVAADSCEECGAQLLDVDWK 789
Query: 599 KKATPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 658
K +PL G+T + GC++CDELL +L E+KH
Sbjct: 790 KGHSPLAGGATQYTGCVVCDELLAALCEVKHAKAVVKRAGGRGGRGRGRGRGRGRGRGRS 849
Query: 659 MVDPKMSFRDF 669
DP+MSFRDF
Sbjct: 850 RGDPRMSFRDF 860
>G3HFY0_CRIGR (tr|G3HFY0) DNA topoisomerase OS=Cricetulus griseus GN=I79_009497
PE=3 SV=1
Length = 862
Score = 697 bits (1799), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/626 (52%), Positives = 434/626 (69%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE-IQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FK E +W + + ++ E + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKSETYWVLQAKVHNNKEESLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++TK RP+ LNTV +L+VASSALG GP AMQ+AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKTKQRPLALNTVEMLRVASSALGMGPQHAMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ KG V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQKGDTFAVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+H+V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
+G LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ENGVLVLDPTSGPKWKVACNTCNVVAHCFENAHRVRVSADNCNTCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GCI CD + LVE+KH
Sbjct: 790 LPGNETQHTGCIFCDPVFQELVELKH 815
>G5BKF9_HETGA (tr|G5BKF9) DNA topoisomerase OS=Heterocephalus glaber GN=GW7_15349
PE=3 SV=1
Length = 862
Score = 697 bits (1798), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/626 (52%), Positives = 431/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDKSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASSALG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LLT G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKQLLTEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A ED LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMRSATEDELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFQIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCIEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGILVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCNTCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPVFQELVELKH 815
>H0UX40_CAVPO (tr|H0UX40) DNA topoisomerase OS=Cavia porcellus GN=LOC100734860
PE=3 SV=1
Length = 862
Score = 697 bits (1798), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/626 (52%), Positives = 431/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNVEKDKSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASSALG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LLT G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGCLRQQANHPYWADTVKQLLTEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A ED LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMRSATEDELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFAVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGILVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCNTCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPVFQELVELKH 815
>R7VUT8_COLLI (tr|R7VUT8) DNA topoisomerase 3-beta-1 OS=Columba livia
GN=A306_02167 PE=4 SV=1
Length = 862
Score = 695 bits (1793), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/629 (52%), Positives = 431/629 (68%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W VNP S + L+W R +
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNPEKESS---LTLDWDRVR 263
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD +A MF + +V +S+K++ K RP+ LNTV +L+VAS+ALG GP AMQ
Sbjct: 264 VFDREIAQMFLNITKTAKEAKVESVSKKEKVKQRPLALNTVEMLRVASAALGMGPQHAMQ 323
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLYTQG+ISYPRTE+T YP +FD +G L QANNP W V+ LL+ G +PR G D
Sbjct: 324 IAERLYTQGYISYPRTETTHYPENFDLKGCLRQQANNPYWAETVKALLSEGINRPRKGHD 383
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPMR A E LG D W+LY+YI +HFI TVS DCKY + + FSIG E F C
Sbjct: 384 AGDHPPITPMRAATEAELGGDGWRLYEYITRHFIATVSADCKYLQTTIAFSIGPERFTCV 443
Query: 243 GQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ V + GFT IMPW +I ++++P KG +S+++L E T+PPDYLTE+ELI+LM
Sbjct: 444 GKVVTSPGFTEIMPWHSIALEESLPHCEKGDLFPISEIKLLEKQTSPPDYLTEAELITLM 503
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
EK+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 504 EKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSA 563
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ LIA G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+
Sbjct: 564 VEKQLNLIALGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSR 623
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 624 CGKCHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 683
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HPTC +SL G+ C
Sbjct: 684 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQC 726
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC +G LVLD S PKW++ CN CN +V + AH++ + E C CD+++++VDFNK
Sbjct: 727 VECENGVLVLDSTSGPKWKMACNKCNVIVHFFENAHKVRVSPETCDLCDAALVDVDFNKA 786
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 787 KSPLPGDETQHSGCVFCDPVFQDLVELKH 815
>Q5ZK71_CHICK (tr|Q5ZK71) DNA topoisomerase OS=Gallus gallus GN=TOP3B PE=2 SV=1
Length = 862
Score = 694 bits (1792), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/629 (52%), Positives = 433/629 (68%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W VNP S + L+W R +
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNPEKESS---LTLDWDRVR 263
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD +A MF + +V +S+K++ K RP+ LNTV +L+VAS+ALG GP AMQ
Sbjct: 264 VFDREIAQMFLNITKMAKEAKVESVSKKEKVKQRPLALNTVEMLRVASAALGMGPQHAMQ 323
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLYTQG+ISYPRTE+T YP +FD +G L QANNP W V+ LL+ G +PR G D
Sbjct: 324 IAERLYTQGYISYPRTETTHYPENFDLKGCLRQQANNPYWAETVKALLSEGINRPRKGHD 383
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPM+ A E LG D+W+LY+YI +HFI TVS DCKY + + FSIG E F+C
Sbjct: 384 AGDHPPITPMKAATEVELGGDSWRLYEYITRHFIATVSADCKYLQTNISFSIGPERFNCV 443
Query: 243 GQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ V + GFT IMPW +I ++++PS KG V +++L E T+PPDYLTE+ELI+LM
Sbjct: 444 GKVVTSPGFTEIMPWHSIALEESLPSCEKGDLFPVGEIKLLEMQTSPPDYLTEAELITLM 503
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
EK+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 504 EKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSA 563
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ LIA G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+
Sbjct: 564 VEKQLNLIALGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSR 623
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 624 CGKCHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 683
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HPTC +SL G+ C
Sbjct: 684 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQC 726
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC +G LVLD S PKW++ CN CN +V + AH++ + E C CD+++++VDFNK
Sbjct: 727 VECENGVLVLDSTSGPKWKMACNKCNVIVHFFENAHKVRVSPETCELCDAALVDVDFNKA 786
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 787 KSPLPGDETQHSGCVFCDPVFQDLVELKH 815
>Q3UJF5_MOUSE (tr|Q3UJF5) DNA topoisomerase OS=Mus musculus GN=Top3b PE=2 SV=1
Length = 862
Score = 694 bits (1791), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/627 (52%), Positives = 432/627 (68%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + VH+ E + L+W R ++F
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAK-VHTDKEESLLLDWDRVRVF 265
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + + V S K++ K RP+ LNTV +L+VASSALG GP AMQ+A
Sbjct: 266 DWEIAQMFLNMTKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIA 325
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D G
Sbjct: 326 ERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAG 385
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C G+
Sbjct: 386 DHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGK 445
Query: 245 HVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
VI+ GFT IMPW ++ ++++P+ KG V +V++ E T+PPDYLTE+ELI+LMEK
Sbjct: 446 TVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEK 505
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E
Sbjct: 506 HGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVE 565
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ D+H+V+ H + FK+KF YFV I MD L E FS L +G+ LS+CG
Sbjct: 566 KQLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCG 625
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+
Sbjct: 626 KCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSY 685
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYCY++PPF ++ GM C C HPTC +SL G+ C E
Sbjct: 686 PLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVE 728
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C +G LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +
Sbjct: 729 CENGVLVLDPTSGPKWKVACNTCNVVAHCFENAHRVRVSADTCNTCEAALLDVDFNKAKS 788
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL T H GCI CD + LVE+KH
Sbjct: 789 PLPGNETQHTGCIFCDPVFQELVELKH 815
>I3NC26_SPETR (tr|I3NC26) DNA topoisomerase OS=Spermophilus tridecemlineatus
GN=TOP3B PE=3 SV=1
Length = 862
Score = 694 bits (1790), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 327/626 (52%), Positives = 431/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDKSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S+K++ K RP+ LNTV +L+VASSALG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVETTSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL+ G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLSEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMRSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFAVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSSDTCNTCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPIFQELVELKH 815
>C3Z1Q7_BRAFL (tr|C3Z1Q7) DNA topoisomerase OS=Branchiostoma floridae
GN=BRAFLDRAFT_80591 PE=3 SV=1
Length = 858
Score = 693 bits (1789), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/627 (52%), Positives = 431/627 (68%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV R+ QI +FKPE +W + + + + L+W R +LFD
Sbjct: 206 LDSSLISFGPCQTPTLGFCVDRHDQIQSFKPETYWVIQTQVSGKNNSPLWLDWDRVRLFD 265
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA F +V +V +++K++ K RP+ LNTV LL+VASS+LG P MQ+AE
Sbjct: 266 REVAQTFLNIVKGAKEAKVVSVTKKEKAKQRPIALNTVELLRVASSSLGMAPQHTMQVAE 325
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L Q N +WG V LL G KPR G+D GD
Sbjct: 326 RLYTQGYISYPRTETTHYPENFDLKGTLRQQTGNSSWGPIVRELLDKGMQKPRKGSDAGD 385
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG + W++Y+YI HFI TVS DCKY + V+F + GESF TG+
Sbjct: 386 HPPITPMRSATESELGGEGWRVYEYITSHFIATVSKDCKYLQTTVKFDVAGESFSVTGKT 445
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I G+TA+M W I+ ++++P F KG V++V+L E T+PPDYLTE+ELISLMEK+
Sbjct: 446 LIDAGYTAVMHWQGISAEESVPHFEKGDVCTVNEVKLAEKQTSPPDYLTEAELISLMEKH 505
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V GRKL+PT LGI LV GYQ IDP+L LP +RS +E
Sbjct: 506 GIGTDASIPVHINNICQRNYVTVGGGRKLIPTPLGIVLVHGYQKIDPELVLPHMRSAVET 565
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ +++ V+QH + F+ KF YFV + MD LFE FS L SG+ LS+CGK
Sbjct: 566 QLNLIAQGKANYNAVLQHALDIFRLKFHYFVDSVSDMDQLFEVTFSPLAASGKPLSRCGK 625
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKY+ A+PSRL+C C+E Y LPQ GT+KLYKE+ CPLD+FEL+L S G GK++P
Sbjct: 626 CRRFMKYVQAKPSRLHCATCDETYNLPQGGTVKLYKEIKCPLDDFELVLFSTGSKGKTYP 685
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC+++PPF ++ M C C HPTC +SL++ GV C EC
Sbjct: 686 LCPYCFNHPPFPDMK-----------------KAMGCNQCTHPTCTHSLINNGVAQCVEC 728
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRIS-TTKERCPECDSSIIEVDFNKKAT 602
G LV+D SAPKW++ CN CN ++ + + AH+++ + E C EC +SII+VDFNK +
Sbjct: 729 EDGVLVMDQTSAPKWKMACNRCNVVINMFENAHKVNVSASEDCEECGASIIDVDFNKAKS 788
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PLE G T H GCI CD +L L+E KH
Sbjct: 789 PLEGGETQHSGCIFCDPILTPLIE-KH 814
>G3NI54_GASAC (tr|G3NI54) DNA topoisomerase (Fragment) OS=Gasterosteus aculeatus
GN=TOP3B PE=3 SV=1
Length = 850
Score = 693 bits (1788), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/627 (52%), Positives = 428/627 (68%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + G + L+W R ++FD
Sbjct: 202 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQVFRGKDG-PLTLDWNRVRVFDR 260
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+V MF + +V +S+K++ K RP LNTV +L+VASS+LG GP MQ+AER
Sbjct: 261 DVGQMFVNMAKTSREAQVESVSKKEKAKQRPQALNTVEMLRVASSSLGMGPQHTMQIAER 320
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+T YP +FD +GAL Q +NP W V+ LL+ G +PR G DVGDH
Sbjct: 321 LYTQGYISYPRTETTHYPENFDLKGALKQQTSNPMWAEEVKALLSTGLNRPRKGADVGDH 380
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A+E LG+D W+LY YI +HFI TVS DCKY + +EFSIG E+F C+G+ +
Sbjct: 381 PPITPMRSASEGELGSDGWRLYDYITRHFIATVSQDCKYLQTTIEFSIGPEAFSCSGKTL 440
Query: 247 ITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
I+ G+TA+MPW I ++ +P +G V +++L E T PPD+LTE+ELI+LMEK+G
Sbjct: 441 ISAGYTAVMPWQGIPLEEAMPVCERGDSFTVDEIKLVEKQTCPPDFLTEAELITLMEKHG 500
Query: 306 IGT--DASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
IGT DASIPVHINNIC+RNYV V+ GRKL PT LGI LV GY D +L LP IRS +E
Sbjct: 501 IGTRTDASIPVHINNICQRNYVTVENGRKLKPTNLGIVLVHGYYKTDAELVLPTIRSAVE 560
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LI+ G+ + +V+QH + FK+KF YFV I +MD L E FS + SG+ LS+CG
Sbjct: 561 KQLNLISLGKANFQQVLQHTLDIFKRKFHYFVDSIPSMDELMEVSFSPIAASGKPLSRCG 620
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL CPLD FEL+L + GP GKS+
Sbjct: 621 KCRRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELRCPLDEFELVLWTSGPRGKSY 680
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYC+SNPPF ++ GM C C HP+C +SL S G+ C E
Sbjct: 681 PLCPYCFSNPPFRDMK-----------------KGMGCNECTHPSCQHSLNSLGIGQCVE 723
Query: 544 CS-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G LVLDP S PKW++ CN CN +V + AHR+ +E C C++S++ VDFNK T
Sbjct: 724 CDGGVLVLDPTSGPKWKMACNKCNVVVHFFEHAHRVQVAQESCDACEASLVAVDFNKTRT 783
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL G T H GC+ CD + LVE+KH
Sbjct: 784 PLPAGETQHTGCVFCDPVFQDLVELKH 810
>G3TL95_LOXAF (tr|G3TL95) DNA topoisomerase OS=Loxodonta africana GN=TOP3B PE=3
SV=1
Length = 862
Score = 692 bits (1786), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 327/626 (52%), Positives = 427/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRTLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNITKMEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKQLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKAATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTITFRIGPEHFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ + N+P+ +G +S++++ E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPPEDNLPTCQRGDTFAISEMKMLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL GV C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGVGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNRCNVVAHCFENAHRVRVAADTCGACEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L G T H GC+ CD + LVE+KH
Sbjct: 790 LPGGETQHIGCVFCDPVFQELVELKH 815
>G3W4B1_SARHA (tr|G3W4B1) DNA topoisomerase OS=Sarcophilus harrisii GN=TOP3B PE=3
SV=1
Length = 765
Score = 692 bits (1786), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/629 (52%), Positives = 436/629 (69%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W +NP S + L+W R +
Sbjct: 110 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPELYWVLQAKINPDKESS---VLLDWDRVR 166
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD +A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ
Sbjct: 167 VFDREIAQMFLNITRTEKEAKVEGTSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQ 226
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W V+ LL +G +PR G D
Sbjct: 227 IAERLYTQGYISYPRTETTHYPENFDLKGSLKQQANHPYWAQTVKQLLADGINRPRKGHD 286
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+
Sbjct: 287 AGDHPPITPMRSATEAELGGDAWRLYEYITRHFIATVSYDCKYLQNTISFQIGPERFTCS 346
Query: 243 GQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ +I+ GFT IMPW +I ++++P+ KG +S+V++ E T+PPDYLTE+ELI+LM
Sbjct: 347 GKTLISPGFTEIMPWQSIPPEESLPTCQKGDTFALSEVKMLEKQTSPPDYLTEAELITLM 406
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
E++GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 407 ERHGIGTDASIPVHINNICQRNYVTVESGRRLRPTNLGIVLVHGYYKIDAELVLPTIRSA 466
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q++LIA G+ D+H+V++H + FK+KF YFV I MD L E FS L +G+ LS+
Sbjct: 467 VEKQLSLIALGKADYHQVLEHTLNIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSR 526
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 527 CGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 586
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HP+C +SL G+ C
Sbjct: 587 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSLLGIGQC 629
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC SG LVLDP S PKW++ CN C+ +V + AHR+ + + C C++++++VDFNK
Sbjct: 630 VECESGVLVLDPTSGPKWKMACNKCSVVVHFFENAHRVRVSADTCEACEAALVDVDFNKA 689
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 690 KSPLPGDETQHTGCVFCDPVFQELVELKH 718
>K1Q3B4_CRAGI (tr|K1Q3B4) DNA topoisomerase 3-beta-1 OS=Crassostrea gigas
GN=CGI_10005154 PE=3 SV=1
Length = 851
Score = 692 bits (1786), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 327/625 (52%), Positives = 422/625 (67%), Gaps = 23/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLG CV R+ +I +FKPE +W P G + ++W R ++FD
Sbjct: 206 LDSTLISYGPCQTPTLGLCVDRHDKIQSFKPEPYWLALP----EGRTVDIDWDRIRVFDK 261
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
VA MF ++ V ++++ ++K+RP LNTV +L+ ASS LG GP AMQ+AER
Sbjct: 262 EVAQMFVNMIKSSDSARVLKVTQDVKSKARPQALNTVEMLRAASSGLGMGPQHAMQMAER 321
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY QG+ISYPRTE+T YP +FD G L QA++ WG+YV+ LL G KP+ GTDVGDH
Sbjct: 322 LYIQGYISYPRTETTQYPENFDLVGTLRQQASSSMWGDYVQNLLREGIQKPKKGTDVGDH 381
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMRPA E LG+DAW+LY +I +HFIGT+SPDCKY + F IG E F CTG V
Sbjct: 382 PPITPMRPATEAELGHDAWRLYDFITRHFIGTISPDCKYLQTTAFFEIGAERFTCTGYRV 441
Query: 247 ITKGFTAIMPWLAINDK-NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
GFTA+M W ++ D+ +P F K +++V++ E T+PPDYLTESELISLMEK+G
Sbjct: 442 TDPGFTAVMSWKSLEDEWTLPEFKKDMDYNITEVKMVEKHTSPPDYLTESELISLMEKHG 501
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNICERNYV V +GR+L PT LGI LV GYQ ID +L LP +RS +E+Q
Sbjct: 502 IGTDASIPVHINNICERNYVTVTSGRRLKPTPLGIVLVHGYQKIDIELVLPTMRSAVEKQ 561
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ LIA G+ V++H + F KF YFV+ I MD LFE FS L +G+ LS+CGKC
Sbjct: 562 LNLIAAGKAYFEDVLKHALNIFCLKFKYFVENIGGMDELFEVTFSPLAATGKPLSRCGKC 621
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKY+ A+PSRL+C C+E Y LPQ G IKLYKEL CPLD+FEL+L + G GKSFPL
Sbjct: 622 RRYMKYVQAKPSRLHCSNCDETYSLPQNGNIKLYKELKCPLDDFELVLWTTGVRGKSFPL 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYC++NPPF + C C HPTC ++L+ GVC C EC
Sbjct: 682 CPYCFNNPPFPDMRKQFG-----------------CNQCTHPTCQHALIQHGVCECVECE 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLDP S PKWR+ CN C ++ + AH++S ++E C +C + I++VDF+K+ TPL
Sbjct: 725 TGILVLDPTSYPKWRMACNKCQVVINFFENAHKVSVSEELCDDCGAHIVDVDFSKEKTPL 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+ T H GC+ CD + +LVE H
Sbjct: 785 PNKETKHSGCVFCDSIFKNLVEKHH 809
>Q7ZWP8_XENLA (tr|Q7ZWP8) DNA topoisomerase OS=Xenopus laevis GN=top3b PE=2 SV=1
Length = 858
Score = 692 bits (1785), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 325/626 (51%), Positives = 424/626 (67%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSG-YEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + H + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQVKVSHGQEHPLSLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + +V +S+K++ K RP LNTV +L+VASSALG GP MQ+AE
Sbjct: 267 REIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QANNP W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGTLKQQANNPFWADTVKTLLAEGINRPRKGADAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI T+S DCKY + + FS+G E F T +
Sbjct: 387 HPPITPMRSATESELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEMFTTTCKE 446
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW I +++ S +G K V +++L E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQGIPKEESFESCQRGDKFSVDEMKLVEKQTCPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINN+C+RNYV V++GR+L PT+LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNVCQRNYVTVESGRRLKPTSLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ + +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKANFQQVLDHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++ PF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHTPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIAQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG +VLD S PKW++ CN CN +V + AHR+ + E C CD++++ VDFNK +P
Sbjct: 730 ESGVMVLDSTSGPKWKMACNKCNVIVHFFENAHRVRVSAETCEACDAALVHVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPADQTQHTGCVFCDSVFQDLVELKH 815
>F1RL05_PIG (tr|F1RL05) DNA topoisomerase OS=Sus scrofa GN=TOP3B PE=2 SV=1
Length = 859
Score = 692 bits (1785), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/626 (52%), Positives = 431/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDQDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S+K++TK RP+ LNTV +L+VASSALG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKPEKEAQVEATSKKEKTKQRPLALNTVEMLRVASSALGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP SFD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPESFDLKGPLRQQANHPYWADTVKQLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG +AW+LY+YI +HFI TVS DC+Y + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGGEAWRLYEYITRHFIATVSHDCRYLQSTISFRIGPERFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ KG V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQKGDTFAVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVVVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ KG G C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCSNHPPFRDMK---------------KGTG--CNECTHPTCQHSLNMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKWR+ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWRVACNRCNVVAHCFENAHRVRVSSDTCSTCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L +T H GC+ CD + LVE+KH
Sbjct: 790 LPGDATQHIGCVFCDPIFQELVELKH 815
>F7ADD1_CALJA (tr|F7ADD1) DNA topoisomerase OS=Callithrix jacchus GN=TOP3B PE=3
SV=1
Length = 862
Score = 691 bits (1784), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 326/626 (52%), Positives = 430/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +GAL QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGALRQQANHPYWADMVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMRSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G VS+V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFTVSEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHMGCVFCDPVFQELVELKH 815
>D4A9Z2_RAT (tr|D4A9Z2) DNA topoisomerase OS=Rattus norvegicus GN=Top3b PE=3
SV=1
Length = 862
Score = 691 bits (1783), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/627 (52%), Positives = 431/627 (68%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + VH+ E + L+W R ++F
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAK-VHTDKEESLLLDWDRVRVF 265
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + + V S+K++ K RP+ LNTV +L+VASSALG GP AMQ+A
Sbjct: 266 DREIAQMFLNMTKLEKEAWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQVA 325
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D G
Sbjct: 326 ERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAG 385
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C G+
Sbjct: 386 DHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGK 445
Query: 245 HVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
VI+ GFT IMPW ++ ++++P+ KG V +V++ E T+PPDYLTE+ELI+LMEK
Sbjct: 446 TVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEK 505
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V+ GR+L PT LGI LV GY ID +L LP IRS +E
Sbjct: 506 HGIGTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVE 565
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ ++H+V+ H + FK+KF YFV I MD L E FS L +G+ LS+CG
Sbjct: 566 KQLNLIAQGKANYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCG 625
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+
Sbjct: 626 KCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSY 685
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYCY++PPF ++ GM C C HPTC +SL G+ C E
Sbjct: 686 PLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVE 728
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C +G LVLDP S PKW++ CN C+ + AHR+ + + C C++++++VDFNK +
Sbjct: 729 CENGVLVLDPTSGPKWKVACNTCSVVAHCFDNAHRVRVSADTCNTCEAALLDVDFNKAKS 788
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL T H GCI CD + LVE+KH
Sbjct: 789 PLPGNETQHTGCIFCDTVFQELVELKH 815
>Q7ZY67_XENLA (tr|Q7ZY67) DNA topoisomerase (Fragment) OS=Xenopus laevis
GN=MGC53016 PE=2 SV=1
Length = 698
Score = 691 bits (1782), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 325/626 (51%), Positives = 424/626 (67%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSG-YEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + H + + L+W R ++FD
Sbjct: 47 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQVKVSHGQEHPLSLDWDRVRVFD 106
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + +V +S+K++ K RP LNTV +L+VASSALG GP MQ+AE
Sbjct: 107 REIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQIAE 166
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QANNP W + V+ LL G +PR G D GD
Sbjct: 167 RLYTQGYISYPRTETTHYPENFDLKGTLKQQANNPFWADTVKTLLAEGINRPRKGADAGD 226
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI T+S DCKY + + FS+G E F T +
Sbjct: 227 HPPITPMRSATESELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEMFTTTCKE 286
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW I +++ S +G K V +++L E T PPDYLTE+ELI+LMEK+
Sbjct: 287 VISPGFTEIMPWQGIPKEESFESCQRGDKFSVDEMKLVEKQTCPPDYLTEAELITLMEKH 346
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINN+C+RNYV V++GR+L PT+LGI LV GY ID +L LP IRS +E+
Sbjct: 347 GIGTDASIPVHINNVCQRNYVTVESGRRLKPTSLGIVLVHGYYKIDAELVLPTIRSAVEK 406
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ + +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 407 QLNLIAQGKANFQQVLDHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 466
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 467 CHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 526
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++ PF ++ GM C C HPTC +SL G+ C EC
Sbjct: 527 LCPYCYNHTPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIAQCVEC 569
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG +VLD S PKW++ CN CN +V + AHR+ + E C CD++++ VDFNK +P
Sbjct: 570 ESGVMVLDSTSGPKWKMACNKCNVIVHFFENAHRVRVSAETCEACDAALVHVDFNKAKSP 629
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 630 LPADQTQHTGCVFCDSVFQDLVELKH 655
>F7FUS9_MONDO (tr|F7FUS9) DNA topoisomerase OS=Monodelphis domestica GN=TOP3B
PE=3 SV=1
Length = 862
Score = 690 bits (1781), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 326/626 (52%), Positives = 432/626 (69%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + I + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPELYWVLQAKINPDKDSSVLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ+AE
Sbjct: 267 REIAHMFLNITRMEKEAKVEGTSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W V+ LL + +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWAQTVKQLLADSINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMRSATEAELGGDAWRLYEYITRHFIATVSYDCKYLQNTISFQIGPERFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+++ GFT IMPW +I ++++P+ KG +S+V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 LLSPGFTEIMPWQSIPPEESLPTCQKGDTFPLSEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLRPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q++LIA G+ D+H+V++H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLSLIALGKADYHQVLEHTLNIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN C+ + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKMACNKCSVVAHFFENAHRVRVSTDTCEACEAALVDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GCI CD + LVE+KH
Sbjct: 790 LLGDETQHTGCIFCDPVFQELVELKH 815
>F6X812_XENTR (tr|F6X812) DNA topoisomerase OS=Xenopus tropicalis GN=top3b PE=3
SV=1
Length = 847
Score = 689 bits (1779), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/627 (52%), Positives = 424/627 (67%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + V G E + L+W R ++F
Sbjct: 196 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQ-VKVSRGQENPLILDWDRVRVF 254
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + +V +S+K++ K RP LNTV +L+VASSALG GP MQ+A
Sbjct: 255 DREIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQIA 314
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G L QANNP W + V+ LL G +PR GTD G
Sbjct: 315 ERLYTQGYISYPRTETTHYPENFDLKGTLRQQANNPFWADMVKTLLAEGINRPRKGTDAG 374
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPMR A E LG DAW+LY+YI +HFI T+S DCKY + + FS+G E F T +
Sbjct: 375 DHPPITPMRSATEAELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEKFTTTCK 434
Query: 245 HVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
VI+ GFT IMPW I +++ +G K V +++L E T PPDYLTE+ELISLME+
Sbjct: 435 EVISPGFTEIMPWQGIPKEESFQPCERGDKFSVDEMKLMEKQTCPPDYLTEAELISLMER 494
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V++GR+L PT+LGI LV GY IDP+L LP IRS +E
Sbjct: 495 HGIGTDASIPVHINNICQRNYVTVESGRRLKPTSLGIVLVHGYYKIDPELVLPTIRSAVE 554
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ + +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CG
Sbjct: 555 KQLNLIAQGKANFQQVLDHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCG 614
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+
Sbjct: 615 KCHRFMKYIQAKPSRLHCSHCDETYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSY 674
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYCY++ PF ++ GM C C HPTC +SL G+ C E
Sbjct: 675 PLCPYCYNHAPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIAQCVE 717
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C SG +VLD S PKW++ CN CN +V + AHR+ + E C CD++++ VDFNK
Sbjct: 718 CESGVMVLDSTSGPKWKMSCNKCNVIVHFFENAHRVRVSAETCDACDAAVVHVDFNKAKC 777
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL T H GC+ CD + LVE+KH
Sbjct: 778 PLPADQTQHAGCVFCDPVFQDLVELKH 804
>G1MQQ8_MELGA (tr|G1MQQ8) DNA topoisomerase OS=Meleagris gallopavo
GN=LOC100545231 PE=3 SV=2
Length = 862
Score = 689 bits (1779), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/629 (52%), Positives = 430/629 (68%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W VNP S + L+W R +
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNPEKESS---LTLDWDRVR 263
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD +A MF + +V +S+K++ K RP+ LNTV +L+VAS+ALG GP AMQ
Sbjct: 264 VFDREIAQMFLNITKTAREAKVESVSKKEKVKQRPLALNTVEMLRVASAALGMGPQHAMQ 323
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLYTQG+ISYPRTE+T YP +FD +G L QANNP W V+ LL+ G +PR G D
Sbjct: 324 IAERLYTQGYISYPRTETTHYPENFDLKGCLRQQANNPYWAETVKALLSEGINRPRKGHD 383
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPM+ A E LG D W+LY+YI +HFI TVS DCKY + + FSIG E F C
Sbjct: 384 AGDHPPITPMKAATEVELGGDGWRLYEYITRHFIATVSADCKYLQTNISFSIGPERFSCV 443
Query: 243 GQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ V + GFT IMPW +I ++++P KG V +++L E T+PPDYLTE+ELI+LM
Sbjct: 444 GKVVTSPGFTEIMPWHSIPLEESLPCCEKGDLFPVGEIKLLEMQTSPPDYLTEAELITLM 503
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
EK+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 504 EKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSA 563
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ LIA G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+
Sbjct: 564 VEKQLNLIALGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSR 623
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 624 CGKCHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 683
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HPTC +SL G+ C
Sbjct: 684 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQC 726
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC +G LVLD S PKW++ CN CN +V + AH++ + E C CD+++++VDFNK
Sbjct: 727 VECENGVLVLDSTSGPKWKMACNKCNVIVHFFENAHKVRVSPETCDLCDAALVDVDFNKA 786
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 787 KSPLPGDETQHSGCVFCDPVFQDLVELKH 815
>F6WCJ0_HORSE (tr|F6WCJ0) DNA topoisomerase OS=Equus caballus GN=TOP3B PE=3 SV=1
Length = 862
Score = 689 bits (1779), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 326/626 (52%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPAWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DCKY + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQSSISFRIGPEHFCCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS+V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFAVSEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVVVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCSNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSACEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPIFQELVELKH 815
>L5LIY6_MYODS (tr|L5LIY6) DNA topoisomerase OS=Myotis davidii
GN=MDA_GLEAN10020152 PE=3 SV=1
Length = 836
Score = 689 bits (1777), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 328/626 (52%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNVDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S+K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSKKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +GAL QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGALRQQANHPYWADTVKQLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DCKY + + F IG E F CT +
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQNTISFRIGPEHFTCTVKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G V +V+L E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKLLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVVVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADFRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + E C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSPETCSSCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE++H
Sbjct: 790 LLGDETQHTGCVFCDPVFQELVELRH 815
>H0ZEB7_TAEGU (tr|H0ZEB7) DNA topoisomerase (Fragment) OS=Taeniopygia guttata
GN=TOP3B PE=3 SV=1
Length = 839
Score = 688 bits (1775), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/629 (52%), Positives = 430/629 (68%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W VNP S + L+W R +
Sbjct: 184 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNPEKESS---LTLDWDRVR 240
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD VA MF + +V +S+K++ K RP+ LNTV +L+VAS+ALG GP AMQ
Sbjct: 241 VFDREVAQMFLNITKMAKEAKVESVSKKEKVKQRPLALNTVEMLRVASAALGMGPQHAMQ 300
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLYTQG+ISYPRTE+T YP +FD +G L QANNP W V+ LL+ G +PR G D
Sbjct: 301 IAERLYTQGYISYPRTETTHYPENFDLKGCLRQQANNPYWAETVKVLLSEGINRPRKGHD 360
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPMR A E LG D W+LY+YI +HFI TVS DCKY + + FSIG E F C
Sbjct: 361 AGDHPPITPMRAATEAELGGDGWRLYEYITRHFIATVSADCKYLQTTISFSIGPERFTCV 420
Query: 243 GQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ V + GFT IMPW +I ++++P KG + +++L E T+PPDYLTE+ELI+LM
Sbjct: 421 GKVVTSPGFTEIMPWHSIPLEESLPHCEKGDLFPIGEIKLLEKQTSPPDYLTEAELITLM 480
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
EK+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 481 EKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSA 540
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ LIA G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+
Sbjct: 541 VEKQLNLIALGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSR 600
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 601 CGKCHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 660
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HPTC +SL G+ C
Sbjct: 661 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQC 703
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC +G LVLD S PKW++ CN CN +V + AH++ + E C C++++++VDFNK
Sbjct: 704 VECENGVLVLDSTSGPKWKMACNKCNVVVHFFENAHKVRVSPETCDLCEAALVDVDFNKA 763
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 764 KSPLPGDETQHSGCVFCDPVFQDLVELKH 792
>R0L3G6_ANAPL (tr|R0L3G6) DNA topoisomerase 3-beta-1 (Fragment) OS=Anas
platyrhynchos GN=Anapl_06909 PE=4 SV=1
Length = 846
Score = 687 bits (1773), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 328/629 (52%), Positives = 429/629 (68%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W VNP S + L+W R +
Sbjct: 191 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNPEKESS---LTLDWDRVR 247
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD +A MF + +V +S+K++ K RP+ LNTV +L+VAS+ALG GP AMQ
Sbjct: 248 VFDREIAQMFLNITKMAKEAKVESVSKKEKVKQRPLALNTVEMLRVASAALGMGPQHAMQ 307
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLY QG+ISYPRTE+T YP +FD +G L QANNP W V+ LL+ G +PR G D
Sbjct: 308 IAERLYMQGYISYPRTETTHYPENFDLKGCLRQQANNPYWAETVKALLSEGINRPRKGHD 367
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPM+ A E LG D W+LY+YI +HFI TVS DCKY + + FSIG E F C
Sbjct: 368 AGDHPPITPMKAATEAELGGDGWRLYEYITRHFIATVSADCKYLQTTISFSIGPERFTCI 427
Query: 243 GQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ V + GFT IMPW +I ++++P KG + +++L E T+PPDYLTE+ELI+LM
Sbjct: 428 GKLVTSPGFTEIMPWHSIPLEESLPHCEKGDLFPIGEIKLLEKQTSPPDYLTEAELITLM 487
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
EK+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 488 EKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSA 547
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ LIA G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+
Sbjct: 548 VEKQLNLIALGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSR 607
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C++ Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 608 CGKCHRFMKYIQAKPSRLHCSHCDDTYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 667
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HPTC +SL G+ C
Sbjct: 668 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQC 710
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC +G LVLD S PKW++ CN CN +V + AH++ + E C CD+++++VDFNK
Sbjct: 711 VECENGVLVLDSTSGPKWKMACNKCNVIVHFFENAHKVRVSPETCDLCDAALVDVDFNKA 770
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 771 KSPLPGDETQHSGCVFCDPVFQDLVELKH 799
>H0XH52_OTOGA (tr|H0XH52) DNA topoisomerase OS=Otolemur garnettii GN=TOP3B PE=3
SV=1
Length = 862
Score = 687 bits (1773), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 323/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF L + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNLTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI TVS DC+Y + + F IG E F C+G+
Sbjct: 387 HPPITPMRSATEAELGGDAWRLYEYITRHFIATVSHDCRYLQSTISFRIGPELFTCSGRT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT +MPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEVMPWQSVPLEESLPTCQRGNTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINN+C+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNVCQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVER 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLSHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSLLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCNICEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHVGCVFCDPVFQELVELKH 815
>M3VYV1_FELCA (tr|M3VYV1) DNA topoisomerase OS=Felis catus GN=TOP3B PE=3 SV=1
Length = 862
Score = 687 bits (1772), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 325/626 (51%), Positives = 428/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LLT G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLTEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DCKY + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQSTISFRIGPEHFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS++++ E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFAVSEIKMLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCANHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + A+R+ + + C C+++++ VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCSTCEAALLAVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPIFQELVELKH 815
>G1T303_RABIT (tr|G1T303) DNA topoisomerase OS=Oryctolagus cuniculus GN=TOP3B
PE=3 SV=1
Length = 863
Score = 686 bits (1770), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/626 (51%), Positives = 428/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 208 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPEAYWVLQAKVNVDKDRSLLLDWDRVRVFD 267
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + ++ +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 268 REIAQMFLNMTKQEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 327
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 328 RLYTQGYISYPRTETTHYPENFDLKGCLRQQANHPYWADTVKRLLAEGVNRPRKGHDAGD 387
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + IG E F C+G+
Sbjct: 388 HPPITPMRSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQTTISLRIGPELFTCSGKT 447
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V++V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 448 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFAVAEVKMLEKQTSPPDYLTEAELITLMEKH 507
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LG+ LV GY ID +L LP IRS +E+
Sbjct: 508 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGVVLVHGYYKIDAELVLPTIRSAVEK 567
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 568 QLNLIAQGKADYRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 627
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GK++P
Sbjct: 628 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKAYP 687
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+CP+SL G+ C EC
Sbjct: 688 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCPHSLSMLGIGQCVEC 730
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G LVLD S PKW++ CN CN + + A+R+ + + CP C+++++ VDFNK P
Sbjct: 731 ERGVLVLDATSGPKWKVACNKCNVVAHCFENAYRVRVSADTCPSCEAALLHVDFNKAKCP 790
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 791 LPGDETQHTGCVFCDPVFQELVELKH 816
>K9IP36_DESRO (tr|K9IP36) DNA topoisomerase OS=Desmodus rotundus PE=2 SV=1
Length = 862
Score = 686 bits (1769), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 326/626 (52%), Positives = 427/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDRIQSFKPETYWVLQAKVNADKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWAETVKRLLVEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DCKY + + F IG E F CT +
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQNTISFRIGPEHFTCTVKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P +G V++V+L E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPPCQRGDTFPVAEVKLLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVVVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + E C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSSETCGSCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE++H
Sbjct: 790 LLGDETQHMGCVFCDPVFQELVELRH 815
>H2R4A2_PANTR (tr|H2R4A2) DNA topoisomerase OS=Pan troglodytes GN=TOP3B PE=2 SV=1
Length = 862
Score = 686 bits (1769), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 322/626 (51%), Positives = 428/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT +MPW ++ ++++P+ +G V +V++ E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGNETQHMGCVFCDPVFQELVELKH 815
>E2R770_CANFA (tr|E2R770) DNA topoisomerase OS=Canis familiaris GN=TOP3B PE=3
SV=2
Length = 862
Score = 686 bits (1769), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 325/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DCKY + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQSTISFRIGPEHFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS++++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDCFPVSEMKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCSNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + A+R+ + + CP C+++++ VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCPTCEAALLAVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPVFQELVELKH 815
>G1PFL3_MYOLU (tr|G1PFL3) DNA topoisomerase OS=Myotis lucifugus PE=3 SV=1
Length = 862
Score = 686 bits (1769), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 326/626 (52%), Positives = 428/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S+K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSKKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKQLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DCKY + + F IG E F CT +
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCKYLQNTISFRIGPEHFTCTVKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G V +V+L E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKLLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVVVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADFRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + E C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSPETCSSCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE++H
Sbjct: 790 LLGDETQHTGCVFCDPVFQELVELRH 815
>H2P4Z3_PONAB (tr|H2P4Z3) DNA topoisomerase OS=Pongo abelii GN=TOP3B PE=3 SV=1
Length = 862
Score = 685 bits (1768), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 323/626 (51%), Positives = 428/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKQLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V +V++ E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHMGCVFCDPVFQELVELKH 815
>G1LLS2_AILME (tr|G1LLS2) DNA topoisomerase OS=Ailuropoda melanoleuca GN=TOP3B
PE=3 SV=1
Length = 862
Score = 685 bits (1768), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 324/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNVDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DC+Y + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCRYLQSTISFRIGPEHFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS++++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFPVSEMKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLRPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCSNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + A+R+ + + C C+++++ VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCSTCEAALLAVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPIFQELVELKH 815
>F7ES60_XENTR (tr|F7ES60) DNA topoisomerase OS=Xenopus tropicalis GN=top3b PE=3
SV=1
Length = 859
Score = 685 bits (1767), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/628 (52%), Positives = 424/628 (67%), Gaps = 23/628 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + V G E + L+W R ++F
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQ-VKVSRGQENPLILDWDRVRVF 265
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + +V +S+K++ K RP LNTV +L+VASSALG GP MQ+A
Sbjct: 266 DREIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQIA 325
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G L QANNP W + V+ LL G +PR GTD G
Sbjct: 326 ERLYTQGYISYPRTETTHYPENFDLKGTLRQQANNPFWADMVKTLLAEGINRPRKGTDAG 385
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPMR A E LG DAW+LY+YI +HFI T+S DCKY + + FS+G E F T +
Sbjct: 386 DHPPITPMRSATEAELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEKFTTTCK 445
Query: 245 HVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
VI+ GFT IMPW I +++ +G K V +++L E T PPDYLTE+ELISLME+
Sbjct: 446 EVISPGFTEIMPWQGIPKEESFQPCERGDKFSVDEMKLMEKQTCPPDYLTEAELISLMER 505
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V++GR+L PT+LGI LV GY IDP+L LP IRS +E
Sbjct: 506 HGIGTDASIPVHINNICQRNYVTVESGRRLKPTSLGIVLVHGYYKIDPELVLPTIRSAVE 565
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIE-AMDALFEAQFSTLVDSGRILSKC 422
+Q+ LIA+G+ + +V+ H + FK+KF YFV I MD L E FS L +G+ LS+C
Sbjct: 566 KQLNLIAQGKANFQQVLDHTLDIFKRKFHYFVDSIAVGMDELMEVSFSPLAATGKPLSRC 625
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS
Sbjct: 626 GKCHRFMKYIQAKPSRLHCSHCDETYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKS 685
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+PLCPYCY++ PF ++ GM C C HPTC +SL G+ C
Sbjct: 686 YPLCPYCYNHAPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIAQCV 728
Query: 543 EC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKA 601
EC SG +VLD S PKW++ CN CN +V + AHR+ + E C CD++++ VDFNK
Sbjct: 729 ECESGVMVLDSTSGPKWKMSCNKCNVIVHFFENAHRVRVSAETCDACDAAVVHVDFNKAK 788
Query: 602 TPLEDGSTLHRGCILCDELLHSLVEMKH 629
PL T H GC+ CD + LVE+KH
Sbjct: 789 CPLPADQTQHAGCVFCDPVFQDLVELKH 816
>M3ZQ84_XIPMA (tr|M3ZQ84) DNA topoisomerase OS=Xiphophorus maculatus GN=TOP3B
PE=3 SV=1
Length = 858
Score = 684 bits (1766), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/626 (51%), Positives = 425/626 (67%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVFKGKDTPLTLDWNRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
V MF L +V +S+K++ K RP LNTV +L+VASSALG GP MQ+AE
Sbjct: 267 REVGQMFVNLAKISKEAKVESVSKKEKVKQRPQALNTVEMLRVASSALGMGPQHTMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T Y +FD +G L Q NN W V+ LL+ G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTLYHENFDLKGTLKQQINNTIWAEEVKALLSTGINRPRKGNDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+E LG+D W+LY+YI +HFI TVS DC+Y + ++F IG E+F C+G+
Sbjct: 387 HPPITPMRSASEGELGSDGWRLYEYITRHFIATVSQDCQYLQTTIDFKIGTEAFSCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I+ G+T +MPW I ++ +P+ G V +++L E T+PP YLTE+ELI+LMEK+
Sbjct: 447 LISPGYTTVMPWQGIPLEEAMPACDCGDTFTVEEIKLVEQQTSPPHYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINN+C+RNYV V+ GR+L PT LGI LV GY D +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNVCQRNYVTVENGRRLKPTNLGIVLVHGYYKTDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ ++ +V+QH ++ FK+KF YFV I +MD L E FS + +G+ LS+CGK
Sbjct: 567 QLNLIAQGKANYQQVLQHTLEIFKRKFHYFVDSITSMDELMEVSFSPIAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL CPLD+FEL+L + G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELRCPLDDFELVLWTSGARGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC+S+PPF ++ GM C C HPTC +SL + G+ C EC
Sbjct: 687 LCPYCFSHPPFRDMK-----------------KGMGCNECTHPTCQHSLNALGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKWR+ CN CN +V + AH+I +E C CD+S++ VDFNK TP
Sbjct: 730 DSGILVLDPTSGPKWRMACNKCNVVVHFFEHAHKIQVAQESCDACDASLVAVDFNKTRTP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L D T H GC+ CD + +VE+KH
Sbjct: 790 LPDNETQHTGCVFCDPVFQDVVELKH 815
>G7PHB7_MACFA (tr|G7PHB7) DNA topoisomerase OS=Macaca fascicularis GN=EGM_02484
PE=3 SV=1
Length = 862
Score = 684 bits (1766), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 322/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN C+ + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCSVVAHCFENAHRVRVSTDTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHMGCVFCDPVFQELVELKH 815
>F7GH88_MACMU (tr|F7GH88) DNA topoisomerase OS=Macaca mulatta GN=TOP3B PE=2 SV=1
Length = 862
Score = 684 bits (1766), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 322/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN C+ + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCSVVAHCFENAHRVRVSTDTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHMGCVFCDPVFQELVELKH 815
>D2I7M2_AILME (tr|D2I7M2) DNA topoisomerase (Fragment) OS=Ailuropoda melanoleuca
GN=PANDA_021957 PE=3 SV=1
Length = 839
Score = 684 bits (1764), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 324/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 184 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNVDKDRSLLLDWDRVRVFD 243
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 244 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 303
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 304 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 363
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG++AW+LY+YI +HFI TVS DC+Y + + F IG E F CTG+
Sbjct: 364 HPPITPMRSATEAELGSEAWRLYEYITRHFIATVSYDCRYLQSTISFRIGPEHFTCTGKT 423
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS++++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 424 VISPGFTEIMPWQSVPLEESLPTCQRGDTFPVSEMKMLEKQTSPPDYLTEAELITLMEKH 483
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 484 GIGTDASIPVHINNICQRNYVTVESGRRLRPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 543
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 544 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 603
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 604 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 663
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 664 LCPYCSNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 706
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + A+R+ + + C C+++++ VDFNK +P
Sbjct: 707 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCSTCEAALLAVDFNKAKSP 766
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 767 LPGDETQHTGCVFCDPIFQELVELKH 792
>H9EST7_MACMU (tr|H9EST7) DNA topoisomerase OS=Macaca mulatta GN=TOP3B PE=2 SV=1
Length = 862
Score = 683 bits (1763), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/626 (51%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CG+
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGR 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN C+ + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCSVVAHCFENAHRVRVSTDTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHMGCVFCDPVFQELVELKH 815
>G8F1W3_MACMU (tr|G8F1W3) DNA topoisomerase OS=Macaca mulatta GN=EGK_21503 PE=3
SV=1
Length = 862
Score = 683 bits (1762), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/626 (51%), Positives = 428/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 ALSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN C+ + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCSVVAHCFENAHRVRVSTDTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDKTQHMGCVFCDPVFQELVELKH 815
>C0H9Z6_SALSA (tr|C0H9Z6) DNA topoisomerase OS=Salmo salar GN=TOP3B PE=2 SV=1
Length = 857
Score = 683 bits (1762), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 322/627 (51%), Positives = 422/627 (67%), Gaps = 22/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + V G E + L+W R ++F
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVIQAK-VFKGKESPLTLDWDRVRVF 265
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D V MF + +V +S+K++ K RP+ LNTV +L+VASS+LG GP MQ+A
Sbjct: 266 DREVGQMFVNMTKTSREAKVESVSKKEKAKQRPLALNTVEMLRVASSSLGMGPQHTMQIA 325
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+ Y +FD +G L QANNP W V+ LL+ G +PR G D G
Sbjct: 326 ERLYTQGYISYPRTETNHYHDNFDLKGTLRQQANNPFWAQEVKALLSEGLNRPRKGADAG 385
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPMR A+E LG+D W+LY+YI +HFI TVS DCKY + + F+I E F C+G+
Sbjct: 386 DHPPITPMRAASEGELGSDGWRLYEYIVRHFIATVSQDCKYLQTTISFTIASEGFSCSGK 445
Query: 245 HVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+I+ GFT +MPWL I ++ +P +G V +++L E T PPDYLTE++LI+LMEK
Sbjct: 446 TLISPGFTEVMPWLGIPLEEAMPVCERGDVFTVEEIKLVERQTCPPDYLTEADLITLMEK 505
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNI +RNYV V+ GRKL PT LGI LV GY D +L LP IR +E
Sbjct: 506 HGIGTDASIPVHINNISQRNYVTVENGRKLKPTNLGIVLVHGYYKTDAELVLPTIRGAVE 565
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ ++ +V+QH + FK+KF YF I +MD L E FS + +G+ LS+CG
Sbjct: 566 KQLNLIAQGKANYQQVLQHTLDIFKRKFHYFFDTIASMDELMEVTFSPIAATGKPLSRCG 625
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL CPLD FEL+L + G GKS+
Sbjct: 626 KCHRFMKYIQAKPSRLHCAGCDETYSLPQNGAIKLYKELRCPLDEFELVLWTSGSRGKSY 685
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYC+SNPPF ++ GM C C HP+C +SL S G+ C E
Sbjct: 686 PLCPYCFSNPPFRDMK-----------------KGMGCNECTHPSCQHSLNSLGIGQCVE 728
Query: 544 CS-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G LVLDP S PKW++ CN CN +V + AHR+ +E C C++S++ VDFNK +
Sbjct: 729 CEGGVLVLDPTSGPKWKMACNRCNVMVHFFEHAHRVQVAQESCEACEASLVAVDFNKTRS 788
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL DG H GC+ CD + LVE+KH
Sbjct: 789 PLPDGEMQHSGCVFCDPVFQDLVELKH 815
>G9KUN5_MUSPF (tr|G9KUN5) DNA topoisomerase (Fragment) OS=Mustela putorius furo
PE=2 SV=1
Length = 861
Score = 682 bits (1761), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 323/626 (51%), Positives = 426/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNVDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG +AW+LY+YI +HFI TVS DCKY + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGGEAWRLYEYITRHFIATVSYDCKYLQSTIAFRIGSEHFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS++++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFPVSEIKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C C
Sbjct: 687 LCPYCSNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVGC 729
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G LVLDP S PKW++ CN CN + + A+R+ + + C C+++++ VDFNK +P
Sbjct: 730 EGGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCSTCEAALLAVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPIFQELVELKH 815
>M3XVK3_MUSPF (tr|M3XVK3) DNA topoisomerase OS=Mustela putorius furo GN=TOP3B
PE=3 SV=1
Length = 862
Score = 682 bits (1761), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 323/626 (51%), Positives = 426/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNVDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG +AW+LY+YI +HFI TVS DCKY + + F IG E F CTG+
Sbjct: 387 HPPITPMRSATEAELGGEAWRLYEYITRHFIATVSYDCKYLQSTIAFRIGSEHFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ +G VS++++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQRGDTFPVSEIKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF ++ GM C C HPTC +SL G+ C C
Sbjct: 687 LCPYCSNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVGC 729
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G LVLDP S PKW++ CN CN + + A+R+ + + C C+++++ VDFNK +P
Sbjct: 730 EGGVLVLDPTSGPKWKVACNKCNVVAHCFENAYRVRVSADTCSTCEAALLAVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHTGCVFCDPIFQELVELKH 815
>A8K4N2_HUMAN (tr|A8K4N2) DNA topoisomerase OS=Homo sapiens PE=2 SV=1
Length = 862
Score = 681 bits (1757), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/626 (51%), Positives = 427/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT +MPW ++ ++++P+ +G V +V++ E T PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GI TDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GICTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKW++ CN CN + + AHR+ + + C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDETQHMGCVFCDPVFQELVELKH 815
>G1TFH8_RABIT (tr|G1TFH8) DNA topoisomerase OS=Oryctolagus cuniculus GN=TOP3B
PE=3 SV=1
Length = 848
Score = 681 bits (1756), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/627 (51%), Positives = 428/627 (68%), Gaps = 21/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 208 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPEAYWVLQAKVNVDKDRSLLLDWDRVRVFD 267
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + ++ +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 268 REIAQMFLNMTKQEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 327
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 328 RLYTQGYISYPRTETTHYPENFDLKGCLRQQANHPYWADTVKRLLAEGVNRPRKGHDAGD 387
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + IG E F C+G+
Sbjct: 388 HPPITPMRSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQTTISLRIGPELFTCSGKT 447
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V++V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 448 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFAVAEVKMLEKQTSPPDYLTEAELITLMEKH 507
Query: 305 GIG-TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
GIG TDASIPVHINNIC+RNYV V++GR+L PT LG+ LV GY ID +L LP IRS +E
Sbjct: 508 GIGGTDASIPVHINNICQRNYVTVESGRRLKPTNLGVVLVHGYYKIDAELVLPTIRSAVE 567
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CG
Sbjct: 568 KQLNLIAQGKADYRQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCG 627
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GK++
Sbjct: 628 KCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKAY 687
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYCY++PPF ++ GM C C HP+CP+SL G+ C E
Sbjct: 688 PLCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCPHSLSMLGIGQCVE 730
Query: 544 CS-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G LVLD S PKW++ CN CN + + A+R+ + + CP C+++++ VDFNK
Sbjct: 731 CERGVLVLDATSGPKWKVACNKCNVVAHCFENAYRVRVSADTCPSCEAALLHVDFNKAKC 790
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
PL T H GC+ CD + LVE+KH
Sbjct: 791 PLPGDETQHTGCVFCDPVFQELVELKH 817
>F6ST44_CIOIN (tr|F6ST44) DNA topoisomerase (Fragment) OS=Ciona intestinalis
GN=LOC100179759 PE=3 SV=2
Length = 820
Score = 680 bits (1754), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 328/629 (52%), Positives = 431/629 (68%), Gaps = 23/629 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV--HSGYEIQLEWQRSKLF 64
L + SYGPCQTPTLGFCV R+ +I +FKPE FW ++ + ++G I LEW R ++F
Sbjct: 172 LDSSLISYGPCQTPTLGFCVDRHDKIQSFKPEPFWMIDVSVKCPNNGPSITLEWARGRIF 231
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
+ VA M+ ++ E+ + + I +K++TK RP LNTV +L+VAS++LG GP AMQ A
Sbjct: 232 EQPVAKMYLSIIKENKIAVIENILKKEKTKQRPQALNTVEMLRVASASLGIGPQQAMQSA 291
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
E LYT+G+ISYPRTE+T YP +FDFR +LS Q + +WG+ LL+ G KPR G+D G
Sbjct: 292 EHLYTRGYISYPRTETTHYPENFDFRSSLSQQTKSRSWGDSASTLLSQGITKPRKGSDAG 351
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPM A E +G+D W+LY+YI +HFI ++SPDC Y + F + ESF CTG
Sbjct: 352 DHPPITPMLCATEQEVGHDNWRLYEYIVRHFIASLSPDCTYLHTVINFKLAEESFSCTGN 411
Query: 245 HVITKGFTAIMPWLAINDKN-IPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+ GFT +MPW +IND+ +P+ +G K EV K L E T+PPDYLTESELI LMEK
Sbjct: 412 SPLKPGFTEVMPWHSINDQQTLPTLTEGGKCEVEKTNLLERKTSPPDYLTESELIMLMEK 471
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIP HINNI +RNYV V +GRKL PT LGI LV GY+ IDPDL LP +RS +E
Sbjct: 472 HGIGTDASIPTHINNIGQRNYVTVISGRKLQPTNLGIMLVHGYKKIDPDLALPTMRSAVE 531
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA G+ + V++H + F+QKF YFV + +MD+LFE F+ L +SG+ +S+CG
Sbjct: 532 KQLNLIALGKAKYTDVLKHAVTIFQQKFHYFVAHVTSMDSLFEVTFTPLSESGKPMSRCG 591
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYISA P RLYC C+E Y LP K +KLYKEL CPLD FELL+CS G +GK++
Sbjct: 592 KCRRFMKYISAAPPRLYCNTCDETYDLPPKTNVKLYKELKCPLDEFELLVCSTGTNGKTY 651
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
LCPYCY++PPF ++ K +G C C HP C +SL S GV C
Sbjct: 652 TLCPYCYNHPPFRDMK---------------KASG--CNSCTHPGCEHSLSSLGVSPCMT 694
Query: 544 C-SGTLVLDPVSAPKWRLCC--NMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
C +G LVLDP S+PKW+L C N C +V L Q AHRI T+E C +C + + VDF+K
Sbjct: 695 CETGILVLDPTSSPKWKLACNDNRCPTVVTLFQHAHRIGVTEETCEKCSAYELAVDFHKD 754
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
TPLE+ T H+GCI CD++ SL+++KH
Sbjct: 755 KTPLENKETKHKGCIFCDQIFSSLIKLKH 783
>H9K0I5_APIME (tr|H9K0I5) DNA topoisomerase OS=Apis mellifera GN=LOC552787 PE=3
SV=1
Length = 851
Score = 677 bits (1748), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 327/621 (52%), Positives = 421/621 (67%), Gaps = 21/621 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCVQR+ +I TFKP+ +W + + S G +I L W R + FD +A
Sbjct: 210 ISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTVKSSDGQDIILNWTRVRSFDKEIAN 269
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MF V E + + ++TKSRP+ LNTV L++VASS LG GPH AMQ+AERLYTQ
Sbjct: 270 MFLSHVKEYDQATIISVESTEKTKSRPIALNTVELMRVASSGLGMGPHHAMQIAERLYTQ 329
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+T YP +FD AL Q NNP WG+ V +LT G +P+ G +VGDHPPIT
Sbjct: 330 GYISYPRTETTLYPENFDLLAALKQQQNNPDWGDQVRKILTTGINRPKKGCNVGDHPPIT 389
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PM+ A + L D W+LY YI +HFI T++ DCKY ++F IG E F G ++ G
Sbjct: 390 PMKHATRNELDGDTWRLYDYITRHFIATLAHDCKYLSTTIKFEIGMEIFTANGHSLLDPG 449
Query: 251 FTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTD 309
+T+I+ W A+ ++ N+P F G+K+ + +++L E T PPDYLTESELISLMEK+GIGTD
Sbjct: 450 YTSILTWQALGSNDNLPRFTPGEKVNIQEIKLVECYTQPPDYLTESELISLMEKHGIGTD 509
Query: 310 ASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLI 369
ASIPVHINNIC RNYV V GRKLVPT+LGI LV GYQ IDP+L LP +RS +E+Q+ LI
Sbjct: 510 ASIPVHINNICMRNYVNVATGRKLVPTSLGIVLVHGYQKIDPELVLPTMRSAVEEQLNLI 569
Query: 370 AKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYM 429
A G+ D H V+QH ++ FKQKF YFVK IEAMD LFE FS L SG+ S+CGKC RYM
Sbjct: 570 ALGRADFHAVLQHTVEIFKQKFHYFVKNIEAMDQLFEVSFSPLSASGKAHSRCGKCRRYM 629
Query: 430 KYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYC 489
KYI +PSR++C C E Y LPQ G I++YKEL CPLD+FELL S G GKSF CPYC
Sbjct: 630 KYIQTKPSRMHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSWSTGARGKSFTFCPYC 689
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC-SGTL 548
Y+NPPF + K SG C C HPTCP+ + S G+ +C EC +G L
Sbjct: 690 YNNPPFRDM-------KKGISG---------CNSCTHPTCPHGMNSNGISSCLECNAGIL 733
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGS 608
VLDP +APKW+L CN C+ ++ L + AH+++ E C EC + ++ V++ ++ + L + S
Sbjct: 734 VLDPSAAPKWKLGCNRCDVIIHLFENAHKVTVDTEVC-ECGAQLVTVEYKQEKSKLPNES 792
Query: 609 TLHRGCILCDELLHSLVEMKH 629
T GC+ C +LVE KH
Sbjct: 793 TEMTGCVFCTPAFMALVE-KH 812
>L8HVJ0_BOSMU (tr|L8HVJ0) DNA topoisomerase (Fragment) OS=Bos grunniens mutus
GN=M91_15502 PE=3 SV=1
Length = 816
Score = 677 bits (1747), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/626 (52%), Positives = 429/626 (68%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + V + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVDVDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASSALG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP SFD +G L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPESFDLKGPLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG +AW+LY+YI +HFI TVS DC+Y + V F IG E F CTG+
Sbjct: 387 HPPITPMKSATEAELGGEAWRLYEYITRHFIATVSHDCRYLQSSVSFRIGPERFTCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW ++ ++++P+ KG + V++V+L E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VISPGFTEIMPWQSVPLEESLPTCQKGDTLAVAEVKLLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVIVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGRADFRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYC ++PPF + K ST C C HP+C +SL G+ C EC
Sbjct: 687 LCPYCSNHPPFRDM-------KKSTG----------CNECTHPSCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP S PKWR+ CN CN + + AHR+ + E C C++++++VDFNK +P
Sbjct: 730 ESGVLVLDPTSGPKWRVACNRCNVVAHCFENAHRVRVSAETCAACEAALLDVDFNKAKSP 789
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 790 LPGDGTQHTGCVFCDPVFQELVELKH 815
>G3W4B0_SARHA (tr|G3W4B0) DNA topoisomerase (Fragment) OS=Sarcophilus harrisii
GN=TOP3B PE=3 SV=1
Length = 802
Score = 667 bits (1720), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 319/629 (50%), Positives = 429/629 (68%), Gaps = 26/629 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW----SVNPYIVHSGYEIQLEWQRSK 62
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W +NP S + L+W R +
Sbjct: 147 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPELYWVLQAKINPDKESS---VLLDWDRVR 203
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+FD +A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ
Sbjct: 204 VFDREIAQMFLNITRTEKEAKVEGTSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQ 263
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AERLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W V+ LL +G +PR G D
Sbjct: 264 IAERLYTQGYISYPRTETTHYPENFDLKGSLKQQANHPYWAQTVKQLLADGINRPRKGHD 323
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPMR A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+
Sbjct: 324 AGDHPPITPMRSATEAELGGDAWRLYEYITRHFIATVSYDCKYLQNTISFQIGPERFTCS 383
Query: 243 GQHVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ +I+ GFT IMPW +I ++++P+ KG +S+V++ E T+PPDYLTE+ELI+LM
Sbjct: 384 GKTLISPGFTEIMPWQSIPPEESLPTCQKGDTFALSEVKMLEKQTSPPDYLTEAELITLM 443
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
E++GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS
Sbjct: 444 ERHGIGTDASIPVHINNICQRNYVTVESGRRLRPTNLGIVLVHGYYKIDAELVLPTIRSA 503
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q++LIA G+ D+H+V++H + FK+KF YFV I + + + + + +
Sbjct: 504 VEKQLSLIALGKADYHQVLEHTLNIFKRKFHYFVDSIAGEEPVGQPRPRAWRAPEQPPPR 563
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GK
Sbjct: 564 CGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGK 623
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
S+PLCPYCY++PPF ++ GM C C HP+C +SL G+ C
Sbjct: 624 SYPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPSCQHSLSLLGIGQC 666
Query: 542 PEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
EC SG LVLDP S PKW++ CN C+ +V + AHR+ + + C C++++++VDFNK
Sbjct: 667 VECESGVLVLDPTSGPKWKMACNKCSVVVHFFENAHRVRVSADTCEACEAALVDVDFNKA 726
Query: 601 ATPLEDGSTLHRGCILCDELLHSLVEMKH 629
+PL T H GC+ CD + LVE+KH
Sbjct: 727 KSPLPGDETQHTGCVFCDPVFQELVELKH 755
>L9LCG8_TUPCH (tr|L9LCG8) DNA topoisomerase OS=Tupaia chinensis
GN=TREES_T100012791 PE=3 SV=1
Length = 946
Score = 665 bits (1717), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 325/661 (49%), Positives = 429/661 (64%), Gaps = 55/661 (8%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 256 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDRSLLLDWDRVRVFD 315
Query: 66 INVATMFQKL---------------------------VAEDGLLEVTEISEKQETKSRPV 98
+A MF L + E + +V S K++ K RP+
Sbjct: 316 REIAQMFLNLTKSEKEAQVRLPRRAFFGVGTGLGDLCLEEQLVPKVEAASRKEKAKQRPL 375
Query: 99 GLNTVNLLKVASSALGFGPHMAMQLAERLYTQG--------FISYPRTESTAYPPSFDFR 150
LNTV +L+VASSALG GP AMQ AERLYTQG +ISYPRTE+T YP +FD +
Sbjct: 376 ALNTVEMLRVASSALGMGPQHAMQTAERLYTQGGPTTHTQGYISYPRTETTHYPENFDLK 435
Query: 151 GALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQY 210
+L QAN+P W + V+ LL G +PR G D GDHPPITPMR A E LG DAW+LY+Y
Sbjct: 436 ASLRQQANHPHWADTVKRLLAEGINRPRKGHDAGDHPPITPMRSATEAELGGDAWRLYEY 495
Query: 211 ICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAIN-DKNIPSFI 269
I +HFI TVS DCKY + + F IG E F C+G+ VI+ GFT IMPW ++ ++++P+
Sbjct: 496 ITRHFIATVSYDCKYLQSSISFRIGPELFSCSGKTVISPGFTEIMPWQSVPLEESLPTCQ 555
Query: 270 KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQA 329
+G V +V++ E T+PPDYLTE+ELI+LMEK+GIGTDASIPVHINN+C+RNYV V++
Sbjct: 556 RGDTFAVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNVCQRNYVTVES 615
Query: 330 GRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQ 389
GR+L PT LGI LV GY ID +L LP IRS +E+Q++LIA+G+ D+ +V+ H + FK+
Sbjct: 616 GRRLRPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLSLIAQGKADYRQVLGHTLDIFKR 675
Query: 390 KFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYY 449
KF YFV I MD L E FS L +G+ LS+CGKC R+MKYI A+PSRL+C C+E Y
Sbjct: 676 KFHYFVSSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYT 735
Query: 450 LPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTST 509
LPQ GTIKLYKEL CPLD+FEL+L S G GKS+PLCPYC+++PPF ++
Sbjct: 736 LPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCFNHPPFRDMK---------- 785
Query: 510 SGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC-SGTLVLDPVSAPKWRLCCNMCNCL 568
GM C C HP+C +SL G+ C EC SG LVLDP S PKW++ CN CN +
Sbjct: 786 -------KGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVV 838
Query: 569 VFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMK 628
AHR+ + C C++++++VDFNK +PL T H GC+ CD + LVE+K
Sbjct: 839 ARCFDDAHRVRVSASTCSTCEAALLDVDFNKAKSPLPGDETQHTGCVFCDPVFQELVELK 898
Query: 629 H 629
H
Sbjct: 899 H 899
>K7J2S1_NASVI (tr|K7J2S1) DNA topoisomerase OS=Nasonia vitripennis PE=3 SV=1
Length = 852
Score = 665 bits (1715), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 320/626 (51%), Positives = 422/626 (67%), Gaps = 20/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L A SYGPCQTPTLGFCVQR+ +I TFKP+ +W + + G ++ L W R + FD
Sbjct: 205 LDASLISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTVKTADGLDVVLSWSRVRSFD 264
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA +F V E VT I +++K+RP+ LNTV L++VASS LG GPH AMQ+AE
Sbjct: 265 KEVANIFLSHVKEHDHATVTSIQSTEKSKARPIALNTVELMRVASSGLGMGPHHAMQIAE 324
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T+YP +FD L Q N+ WG+ V +L++G KP+ G D GD
Sbjct: 325 RLYTQGYISYPRTETTSYPENFDLVSTLKQQQNSSDWGDEVRRILSSGISKPKKGHDAGD 384
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A+ + L D+W+LY YI +HFI T++ DCKY +F IG E+F TG
Sbjct: 385 HPPITPMKSASRNELDGDSWRLYDYITRHFIATLAKDCKYLSTTAKFEIGMETFSVTGHS 444
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I G+T+++ W A+ N++++P F G+++++ + +L E T PPDYLTESELI+LMEK+
Sbjct: 445 LIDPGYTSLLTWQALSNNESLPRFSIGERVKIQESKLLECFTQPPDYLTESELITLMEKH 504
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC RNYV V GRKLVPT+LGI LV GYQ IDP+L LP +RS +E+
Sbjct: 505 GIGTDASIPVHINNICIRNYVNVATGRKLVPTSLGIVLVHGYQKIDPELVLPTMRSAVEE 564
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA G+ D H V+QH ++ FKQKF YFV+ I+AMD LFE FS L SG+ S+CGK
Sbjct: 565 QLNLIALGRADFHAVLQHTVEIFKQKFHYFVQSIDAMDQLFEVSFSPLSASGKSHSRCGK 624
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYMKYI +PSRL+C C E Y LPQ G I++YKEL CPLD+FELL S G GKS+
Sbjct: 625 CRRYMKYIQTKPSRLHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSYSTGTRGKSYT 684
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
CPYC++NPPF + K SG C C HPTCP+ L S G+ +C EC
Sbjct: 685 FCPYCFNNPPFRDM-------KKGLSG---------CNACTHPTCPHGLNSNGLSSCLEC 728
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
SG LVLDP +APKW+L CN C+ ++ L AH++ + +C + ++ V++ + +
Sbjct: 729 ESGILVLDPSAAPKWKLVCNRCDVIIHLFADAHKVMVEADEVCDCGAQLVTVEYKQDKSK 788
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L + +T GC+ C SLVE KH
Sbjct: 789 LPNEATEMTGCVFCTPAFTSLVE-KH 813
>E0VDP5_PEDHC (tr|E0VDP5) DNA topoisomerase OS=Pediculus humanus subsp. corporis
GN=Phum_PHUM122530 PE=3 SV=1
Length = 852
Score = 662 bits (1709), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 323/626 (51%), Positives = 422/626 (67%), Gaps = 22/626 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L A SYGPCQ PTLGFCVQR+ +I TFKPE +W + + SG E LEW+R + F+
Sbjct: 206 LDAALISYGPCQIPTLGFCVQRHDEIQTFKPEPYWVLQMSVKTESGQEATLEWERVRCFE 265
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA MF V E +V+ ++ KQ T S+P+ LNTV L++ ASS LG GPH AMQ+AE
Sbjct: 266 KEVALMFLSQVKEFKEAKVSSVTSKQMTNSKPLALNTVELMRTASSGLGMGPHHAMQIAE 325
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FDF G L Q ++ WG++V +L G KPR G DVGD
Sbjct: 326 RLYTQGYISYPRTETTQYPENFDFIGVLRQQQSSSEWGSFVREILNEGISKPRKGKDVGD 385
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A + ++WKLY YI +HF+ TVS CKY V F I E+F TG+
Sbjct: 386 HPPITPMKLAKRNDFDAESWKLYDYIVRHFLATVSGPCKYLHTVVTFKIASETFKITGKT 445
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ G+TAIMPW A ++ +P+F + ++ V+L E TTPP Y+TE+ELI+ MEK+
Sbjct: 446 LLEPGYTAIMPWEAFGKNETLPNFTVDATVTINDVKLIECQTTPPGYMTEAELITQMEKH 505
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+LVPT+LGI LV GYQ IDP+L LP +RS +E+
Sbjct: 506 GIGTDASIPVHINNICQRNYVTVESGRRLVPTSLGIVLVHGYQKIDPELVLPTMRSAVEE 565
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+GQ V+ H ++ F+QKF YFVK IE MD LFE FS L SG+ S+CGK
Sbjct: 566 QLNLIAQGQAHFDAVLSHSLEIFRQKFLYFVKNIEGMDQLFEVSFSPLATSGKAHSRCGK 625
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYMK I +PSRL+C C+E Y LPQ G I+LYKEL CPLD+FELL + G GKS+P
Sbjct: 626 CRRYMKLIQTKPSRLHCSHCDETYSLPQNGNIRLYKELKCPLDDFELLYWTAGNKGKSYP 685
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
CPYCY++PPF+ ++ G+ C C HP+CPNSL G+C+C EC
Sbjct: 686 FCPYCYNHPPFKDMK-----------------KGIGCNQCSHPSCPNSLNLTGLCSCVEC 728
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G LVLDP S PKW+L CN C+ ++ L + AH+IS ++ C C S +I+V++ ++ +
Sbjct: 729 EGGVLVLDPNSGPKWKLGCNRCDVIIHLFEDAHKISVEEDVC-NCGSQLIKVEYKQEKSK 787
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L + +T GC+ C SLVE KH
Sbjct: 788 LPEEATEMTGCVFCCPSFTSLVE-KH 812
>E2A762_CAMFO (tr|E2A762) DNA topoisomerase OS=Camponotus floridanus GN=EAG_06601
PE=3 SV=1
Length = 851
Score = 661 bits (1705), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 317/621 (51%), Positives = 418/621 (67%), Gaps = 21/621 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCVQR+ +I TFKP+ +W + I S G +I L W R + FD VA
Sbjct: 210 ISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTIKCSDGQDIVLNWSRVRSFDKEVAN 269
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MF V E V + +++KSRP+ LNTV L+++ASS LG GP AMQ+AERLYTQ
Sbjct: 270 MFLSHVKEHDRATVVSVQSTEKSKSRPIALNTVELMRIASSGLGMGPQHAMQIAERLYTQ 329
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+T+YP +FD L Q N+P WG V ++ G +P+ G D GDHPPIT
Sbjct: 330 GYISYPRTETTSYPENFDLLSTLKQQQNSPDWGEEVRKIVAAGINRPKKGHDAGDHPPIT 389
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PM+ A + L D+W+LY YI +HFI T++ DCKY ++F IG E+F TG +++ G
Sbjct: 390 PMKHATRNELDGDSWRLYDYITRHFIATLARDCKYMSTTIKFEIGIETFTATGHSLLSPG 449
Query: 251 FTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTD 309
+T+I+ W A+ N+ +P F +K+ + + +L E T PPDYLTE+ELI+LMEK+GIGTD
Sbjct: 450 YTSILTWQALGNNDTLPKFTLDEKVNIQEAKLIECYTQPPDYLTEAELITLMEKHGIGTD 509
Query: 310 ASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLI 369
ASIPVHINNIC RNYV V AGRKLVPT+LGI LV GYQ IDP+L LP +RS +E+Q+ LI
Sbjct: 510 ASIPVHINNICIRNYVTVAAGRKLVPTSLGIVLVHGYQKIDPELVLPTMRSAVEEQLNLI 569
Query: 370 AKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYM 429
A G+ D H V+QH ++ FKQKF YFV+ IEAMD LFE FS L SG+ S+CGKC RYM
Sbjct: 570 ALGRADFHAVLQHTVEIFKQKFHYFVQSIEAMDQLFEVSFSPLSASGKAHSRCGKCRRYM 629
Query: 430 KYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYC 489
KYI +PSR++C C E Y LPQ G I++YKEL CPLD+FELL S G GKS+ CPYC
Sbjct: 630 KYIQTKPSRMHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSWSTGARGKSYTFCPYC 689
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS-GTL 548
Y+NPPF + K SG C C HPTCP+ + S G+ +C EC G L
Sbjct: 690 YNNPPFRDM-------KKGMSG---------CNSCTHPTCPHGMNSNGLSSCLECDLGIL 733
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGS 608
VLDP +APKW+L CN C+ ++ L + AH+++ + C +C + ++ V++ + + L + +
Sbjct: 734 VLDPSAAPKWKLGCNRCDVIIHLFENAHKVTVDTDTC-DCGAQLVTVEYKQDKSKLPNEA 792
Query: 609 TLHRGCILCDELLHSLVEMKH 629
T GC+ C + +LVE KH
Sbjct: 793 TEMSGCVFCTPVFAALVE-KH 812
>E2BPS8_HARSA (tr|E2BPS8) DNA topoisomerase OS=Harpegnathos saltator GN=EAI_09253
PE=3 SV=1
Length = 851
Score = 656 bits (1693), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 319/621 (51%), Positives = 411/621 (66%), Gaps = 21/621 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCVQR+ +I TFKP+ +W + I G +I L W R + FD VA
Sbjct: 210 ISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTIKCADGQDIILNWSRVRSFDKEVAN 269
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MF V E V I +++KSRP+ LNTV L++VASS LG GP AMQ+AERLYTQ
Sbjct: 270 MFLSHVKEYERATVVSIQSTEKSKSRPIALNTVELMRVASSGLGMGPQHAMQIAERLYTQ 329
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+T+YP +FD L Q NNP WG V +L G +P+ G D GDHPPIT
Sbjct: 330 GYISYPRTETTSYPENFDLLSTLKQQQNNPEWGEDVRKILAAGINRPKKGHDAGDHPPIT 389
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PM+ A + L D+W+LY YI +HFI T++ DCKY V+F IG E F TG ++ G
Sbjct: 390 PMKHATRNELDGDSWRLYDYITRHFIATLARDCKYLSTTVKFEIGMEIFTATGHSLLDAG 449
Query: 251 FTAIMPWLAINDKN-IPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTD 309
+T+I+ W A+ + +P F +K+ + + +L E T PPDYLTE+ELISLMEK+GIGTD
Sbjct: 450 YTSILTWQALGSSDTLPKFTAEEKVNIQEAKLLECYTQPPDYLTEAELISLMEKHGIGTD 509
Query: 310 ASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLI 369
ASIPVHINNIC RNYV V GR+LVPT+LGI LV GYQ IDP+L LP +RS +E+Q+ LI
Sbjct: 510 ASIPVHINNICIRNYVNVTVGRRLVPTSLGIVLVHGYQKIDPELVLPTMRSAVEEQLNLI 569
Query: 370 AKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYM 429
A G+ D H V+QH ++ FKQKF YFV+ IEAMD LFE FS L SG+ S+CGKC RYM
Sbjct: 570 ALGRADFHAVLQHTVEIFKQKFHYFVQSIEAMDQLFEVSFSPLSASGKAHSRCGKCRRYM 629
Query: 430 KYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYC 489
KYI +PSR++C C E Y LPQ G I++YKEL CPLD+FELL S G GKS+ CPYC
Sbjct: 630 KYIQTKPSRMHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSWSTGARGKSYTFCPYC 689
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS-GTL 548
Y+NPPF + K SG C C HPTCP+ + S G+ +C EC G L
Sbjct: 690 YNNPPFRDM-------KKGMSG---------CNSCTHPTCPHGMNSTGLSSCLECDLGIL 733
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGS 608
VLDP +APKW+L CN C+ ++ L + AH+++ + C +C + ++ V++ + + L + +
Sbjct: 734 VLDPSAAPKWKLGCNRCDVIIHLFENAHKVTVDTDVC-DCGAQLVTVEYKQDKSKLPNEA 792
Query: 609 TLHRGCILCDELLHSLVEMKH 629
T GC+ C LVE KH
Sbjct: 793 TEMSGCVFCTSAFAPLVE-KH 812
>D2A047_TRICA (tr|D2A047) DNA topoisomerase OS=Tribolium castaneum GN=GLEAN_07344
PE=3 SV=1
Length = 852
Score = 656 bits (1692), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 317/624 (50%), Positives = 417/624 (66%), Gaps = 23/624 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFD 65
L + SYGPCQTPTLGFCVQR+ QI TFKPE +W + IV G ++ L+W+R + FD
Sbjct: 206 LDSSLISYGPCQTPTLGFCVQRHDQIQTFKPEAYWVIKATIVTKDGNDVHLDWKRVRCFD 265
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA MF + + + +V +S K++ KSRPV LNTV L++VASS LG GPH AMQ+AE
Sbjct: 266 KEVANMFLQQIKDQKHAKVLNVSSKEKAKSRPVALNTVELMRVASSGLGMGPHHAMQIAE 325
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+T YP +FD G L Q N+ WG+ V +L+ G +P+ G D GD
Sbjct: 326 KLYTQGYISYPRTETTRYPENFDLVGVLRQQQNSTEWGDEVREILSRGVNRPKQGHDAGD 385
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A + +D+WKLY YI +HFIGT++ DCKY +I E F TG+
Sbjct: 386 HPPITPMKSATRNEFDSDSWKLYDYITRHFIGTLARDCKYLSTTATIAINEEIFTVTGKT 445
Query: 246 VITKGFTAIMPWLAINDKN--IPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
++ GFT++M W A+ DKN +P+ + + + + + L E T+PPDYLTE+ELI+LME
Sbjct: 446 LLDPGFTSVMTWQAL-DKNEIVPNLTENESVPIKDMRLTEHQTSPPDYLTEAELITLMET 504
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V AGRKL PTTLGI LV GYQ ID +L LP +RS +E
Sbjct: 505 HGIGTDASIPVHINNICQRNYVTVTAGRKLKPTTLGIVLVHGYQKIDAELVLPTMRSAVE 564
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA G+ + V++H ++ FK KF YFVK I+ MD LFE FS L SG+ S+CG
Sbjct: 565 EQLNLIALGKANFQAVLRHTVEIFKLKFQYFVKNIDGMDQLFEVSFSPLSASGKAHSRCG 624
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC RYMKYI A+P RL+C C+E Y LPQ GTIKL+KEL CPLD+FELL +MG GKSF
Sbjct: 625 KCRRYMKYIQAKPPRLHCPQCDETYSLPQNGTIKLFKELKCPLDDFELLYWTMGNKGKSF 684
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
CPYCY++PPF+ ++ GM C C HPTCP S S GVC+C E
Sbjct: 685 VFCPYCYNHPPFKDMK-----------------KGMGCNSCSHPTCPYSFNSNGVCSCVE 727
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C SG LVLDP S PKW+L C C+ ++ L A +++ E C +C + +I +++ + +
Sbjct: 728 CDSGVLVLDPSSGPKWKLGCTRCDTILNLFDDAQKLTVLSEVC-DCGAQLINIEYKPEKS 786
Query: 603 PLEDGSTLHRGCILCDELLHSLVE 626
L +G +GC+ C LV+
Sbjct: 787 KLPNGVAEMKGCVFCTTEFGRLVD 810
>F4WE22_ACREC (tr|F4WE22) DNA topoisomerase OS=Acromyrmex echinatior GN=G5I_03853
PE=3 SV=1
Length = 848
Score = 654 bits (1686), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 316/621 (50%), Positives = 412/621 (66%), Gaps = 21/621 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCVQR+ +I TFKP+ +W + + G +I L W R + FD VA+
Sbjct: 207 ISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTVKSPDGQDIVLSWSRVRSFDKEVAS 266
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MF V E V I ++ KSRP+ LNTV L++VASS LG GP AMQ+AERLYTQ
Sbjct: 267 MFLSHVKEYDQATVVSIQSTEKCKSRPIALNTVELMRVASSGLGMGPQHAMQIAERLYTQ 326
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+T+YP +FD L Q N+ WG V ++ G +P+ G D GDHPPIT
Sbjct: 327 GYISYPRTETTSYPENFDLLSTLKQQQNSSEWGEEVRKIIATGINRPKKGHDAGDHPPIT 386
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PM+ A + L D W+LY YI +HFI T++ DC+Y V+F IG E F TG +++ G
Sbjct: 387 PMKHATRNELDGDLWRLYDYITRHFIATLARDCRYLSTTVKFEIGMEIFTATGHSLLSPG 446
Query: 251 FTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTD 309
+T+I+ W A+ N+ +P F +K+ + + +L E T PPDYLTE+ELISLMEK+GIGTD
Sbjct: 447 YTSILTWQALGNNDTLPKFTSDEKVNIQEAKLVECYTQPPDYLTEAELISLMEKHGIGTD 506
Query: 310 ASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLI 369
ASIPVHINNIC RNYV V AGRKL+PT+LGI LV GYQ IDP+L LP +RS +E+Q+ LI
Sbjct: 507 ASIPVHINNICIRNYVTVAAGRKLIPTSLGIVLVHGYQKIDPELVLPTMRSAVEEQLNLI 566
Query: 370 AKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYM 429
A G+ D H V+QH ++ FKQKF YFV+ IEAMD LFE FS L SG+ S+CGKC RYM
Sbjct: 567 ALGRADFHAVLQHTVEIFKQKFHYFVQSIEAMDQLFEVSFSPLSASGKAHSRCGKCRRYM 626
Query: 430 KYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYC 489
KYI +PSR++C C E Y LPQ G I++YKEL CPLD+FELL S G GKS+ CPYC
Sbjct: 627 KYIQTKPSRMHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSWSTGTRGKSYTFCPYC 686
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS-GTL 548
Y+NPPF + K SG C C HPTCP+ + S G+ +C EC G L
Sbjct: 687 YNNPPFRDM-------KKGMSG---------CNSCTHPTCPHGMNSNGLSSCLECDLGIL 730
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGS 608
VLDP +APKW+L CN C+ ++ L + AH+++ + C +C + ++ V++ + + L +
Sbjct: 731 VLDPSAAPKWKLGCNRCDVIIHLFENAHKVTVDTDTC-DCGAQLVTVEYKQDKSKLPNEV 789
Query: 609 TLHRGCILCDELLHSLVEMKH 629
T GC+ C +LVE KH
Sbjct: 790 TEMSGCVFCTPAFAALVE-KH 809
>G6DFU9_DANPL (tr|G6DFU9) DNA topoisomerase OS=Danaus plexippus GN=KGM_06880 PE=3
SV=1
Length = 848
Score = 653 bits (1685), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 318/625 (50%), Positives = 416/625 (66%), Gaps = 22/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFD 65
L A SYGPCQTPTLGFCVQR+ I TFKPE +W + S G E+ LEW+R + F+
Sbjct: 206 LDASLISYGPCQTPTLGFCVQRHDDIQTFKPETYWVLRVTASTSEGRELPLEWKRVRSFE 265
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
++A MF + E V I K++ KSRP LNTV L++VAS+ LG GPH AMQ+AE
Sbjct: 266 KDIANMFLVGIKEFKEATVVNIQAKEKIKSRPTALNTVELMRVASAGLGMGPHHAMQIAE 325
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T+Y +FD G+L Q N+ WG+ V LL NG KP+ G D GD
Sbjct: 326 RLYTQGYISYPRTETTSYGENFDLIGSLRQQQNSNKWGSEVRALLANGINKPKKGHDAGD 385
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+PA+E L D W++Y YI +HFI T+S DC+Y + FS+G E+F+ TG
Sbjct: 386 HPPITPMKPASESELEGDMWRIYDYITRHFIATLSRDCRYLSTTLTFSVGSETFYYTGNT 445
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ G+T IM W A D+ +P + + L E T+PPDYLTESE+I+LMEK+
Sbjct: 446 LVDAGYTEIMHWQAFGKDEFVPVLKVDEVLRAHDHRLVECQTSPPDYLTESEVITLMEKH 505
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V +GR+LVPT+LG+ LV GYQ IDP+L LP +RS +E+
Sbjct: 506 GIGTDASIPVHINNICQRNYVSVGSGRRLVPTSLGVVLVHGYQKIDPELVLPTMRSAVEE 565
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA G+ D H V+ H + F++KF YFV+ IEAMD LFE FS+L SG+ LS+CGK
Sbjct: 566 QLNLIAIGRADFHAVLTHTTEIFRRKFQYFVRSIEAMDQLFEVSFSSLKTSGKALSRCGK 625
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYM+YI A+P+RL+C C++ Y LPQ GT+++Y+EL CPLD+FELL S G GKSFP
Sbjct: 626 CRRYMRYIQAKPARLHCSHCDDTYTLPQHGTVRIYRELKCPLDDFELLSWSTGSKGKSFP 685
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ G C C HPTCP + S GV C EC
Sbjct: 686 LCPYCYNHPPFRDMK-----------------KGFGCNSCTHPTCPYGVNSTGVSGCVEC 728
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
G LVLDP SAPKW+L CN C+ ++ + + A R+S + C C + ++ V++ + T L
Sbjct: 729 DGVLVLDP-SAPKWKLACNRCDVIINVFEDASRVSVCEAACA-CGAQLVCVEYRAERTKL 786
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
T C+ C+ +LVE KH
Sbjct: 787 PAALTEMTACLYCEPAFSALVE-KH 810
>K7GCG7_PELSI (tr|K7GCG7) DNA topoisomerase OS=Pelodiscus sinensis GN=TOP3B PE=3
SV=1
Length = 806
Score = 648 bits (1671), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 311/574 (54%), Positives = 395/574 (68%), Gaps = 20/574 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSG-YEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + H + LEW R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNHEKESSLTLEWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V +S+K++ K RP+ LNTV +LKVASSALG GP AMQ+AE
Sbjct: 267 REIAQMFLNITKMERDTKVESVSKKEKAKQRPLALNTVEMLKVASSALGMGPQHAMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD + +L Q NNP W V+ LL+ G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKASLRQQTNNPYWAETVKALLSEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E LG D W+LY+YI +HFI TV DCKY + + F IG E F C G+
Sbjct: 387 HPPITPMRAATEAELGGDGWRLYEYITRHFIATVCADCKYLQTTISFIIGPEHFTCVGKM 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I+ GFT IMPW +I ++N+P KG +S+V+L E T PPDYLTE+ELI+LMEK+
Sbjct: 447 IISPGFTEIMPWQSIPLEENLPKCEKGDVFPLSEVKLLEKQTNPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V+ GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ ++H+V++H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKANYHQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 687 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 729
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHR 577
+G LVLDP S PKW++ CN CN LV L A R
Sbjct: 730 ENGVLVLDPTSGPKWKMACNKCNDLVELKHAAMR 763
>K3WPG6_PYTUL (tr|K3WPG6) DNA topoisomerase OS=Pythium ultimum GN=PYU1_G006844
PE=3 SV=1
Length = 856
Score = 645 bits (1664), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 320/639 (50%), Positives = 411/639 (64%), Gaps = 43/639 (6%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV R+ +I F+PE FW+++ + G ++ EW RS+LFD
Sbjct: 201 LDSTLVSYGPCQTPTLGFCVDRHDEIQQFQPEAFWTLDTELAKGGQSVRPEWDRSRLFDH 260
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
V+ G + V + + +SRP LNTV LL++AS L GP+ MQ+AER
Sbjct: 261 EVSLQ--------GEMTVVNVKTSETARSRPTPLNTVTLLQLASKTLSMGPYTTMQIAER 312
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY QG+ISYPRTEST+YP S+D R LS A+NP WG++V+ LL + +P+ G DVGDH
Sbjct: 313 LYLQGYISYPRTESTSYPDSYDIRSTLSHHASNPYWGDHVQKLLNGEFQRPKKGVDVGDH 372
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITP R A L D +LY++I ++FI TVSPD K KV+F+ GGE F +G V
Sbjct: 373 PPITPERSALPSELAGDMGRLYEFITRYFIATVSPDAKLLSTKVQFTCGGEQFSVSGHQV 432
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
I KGFT ++ ++D +P F G+ + ++ V++ G T+PP YLTESELI LMEKNGI
Sbjct: 433 IKKGFTEVLASATLSDTYLPDFTIGEVLPLTSVKVRNGQTSPPGYLTESELIGLMEKNGI 492
Query: 307 GTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQI 366
GTDASI HINNICERNYVQ+ +GR L+PT LGI LV GY +DP+L LP R+ IE+Q
Sbjct: 493 GTDASISAHINNICERNYVQLGSGRTLIPTNLGIVLVHGYYKVDPELVLPRARAAIEEQC 552
Query: 367 TLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCL 426
TLIAKG V+ H + F++KF YFVKKI MD+LFEA FS L +G+ LSKCGKC
Sbjct: 553 TLIAKGVASKEEVLAHSLALFQKKFEYFVKKIAFMDSLFEATFSPLAATGKPLSKCGKCS 612
Query: 427 RYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPD----GKS 482
RYMKY+ +P RL+C C E Y LPQ GTIKLYKEL CPLD FEL+L S+G GKS
Sbjct: 613 RYMKYVKLKPQRLHCAACNETYNLPQNGTIKLYKELRCPLDQFELVLFSLGNTEKAMGKS 672
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC- 541
+PLCPYCY++PPF+ ++ M C C HPTC +SL GV C
Sbjct: 673 YPLCPYCYNHPPFDNMDK------------------MGCDSCLHPTCRHSLTRNGVFMCI 714
Query: 542 --------PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGA---HRISTTK-ERCPECD 589
C+GT+VLD S P W++ CN CN L+ H I T K E C C
Sbjct: 715 GGGENPDAQSCTGTMVLDVNSKPNWKMACNTCNLLIKFQTSTTPIHNIKTRKDESCDACG 774
Query: 590 SSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMK 628
S+ +EV+F+K +PL+DGST + GC+LCDE L++L EMK
Sbjct: 775 STPLEVEFHKDKSPLKDGSTTYIGCVLCDEFLNNLTEMK 813
>F2UL82_SALS5 (tr|F2UL82) DNA topoisomerase OS=Salpingoeca sp. (strain ATCC
50818) GN=PTSG_09515 PE=3 SV=1
Length = 855
Score = 637 bits (1644), Expect = e-180, Method: Compositional matrix adjust.
Identities = 303/620 (48%), Positives = 408/620 (65%), Gaps = 20/620 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATM 71
S+GPCQTPTL CVQR+ I TF+PE +W+++ + + ++L+W R ++FD VA++
Sbjct: 210 LSFGPCQTPTLALCVQRHDLIQTFQPETYWTLDVRALINDSPVKLQWDRVRVFDKTVASL 269
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
F + + +V + K++ K RP LNTV LL++ S+ LG GP AM +AERLY QG
Sbjct: 270 FLHRIQDVRAAKVLRVQSKEKAKPRPTALNTVELLRICSAGLGIGPQQAMVVAERLYIQG 329
Query: 132 FISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITP 191
+ISYPRTE+TAYP +FD L +P WG LL +KP+ G D GDHPPITP
Sbjct: 330 YISYPRTETTAYPANFDTAAVLHELKGSPDWGKEARVLLDGALVKPKGGVDKGDHPPITP 389
Query: 192 MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGF 251
R A ++ L D W++Y +C+H+I T+SPDC+Y+ V ++G E F +GQ +I+ GF
Sbjct: 390 ARLATDNELSGDMWRVYDLVCRHYIATLSPDCRYSVTNVSLAVGSEMFSLSGQRLISPGF 449
Query: 252 TAIMPWLAINDKNI-PSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
T+++ W++ + P +GQ+ + V + E T PP YLTES+LISLMEK+GIGTDA
Sbjct: 450 TSVLYWMSPESSTVVPDMQEGQECIIKNVSISEKQTAPPGYLTESDLISLMEKHGIGTDA 509
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIP HIN ICERNYV VQ GR LVPT LG+ +V GYQ ID DLCLP +R+ +E+Q +LIA
Sbjct: 510 SIPKHINTICERNYVTVQGGRTLVPTNLGVVVVHGYQRIDHDLCLPTMRAAVEKQFSLIA 569
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
GQ ++ V+ + I +K+KF +F + I+ MD LFE F+ L +G+ L +CGKC RY+K
Sbjct: 570 CGQAEYEDVLFYFIDTYKRKFKFFEQNIQLMDELFEVNFTLLSKTGKNLCRCGKCNRYLK 629
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCY 490
I A+P RLYC C++ Y LPQ+G I LYKEL CPLD FEL++CS G +GK+FPLCPYCY
Sbjct: 630 LIIAKPQRLYCPTCDDTYSLPQRGKIMLYKELKCPLDGFELVMCSTGSNGKAFPLCPYCY 689
Query: 491 SNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS-GTLV 549
+NPPFE + KG+G C C + C +S ++ GV C C G LV
Sbjct: 690 NNPPFESMP---------------KGSG--CNACVNALCKHSAINLGVAPCVSCDGGILV 732
Query: 550 LDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGST 609
+DPVS PKWRL CN CN +V L + AH I TK C EC +S + VDF+K +PL+ G T
Sbjct: 733 MDPVSKPKWRLACNQCNTIVTLIENAHDIRVTKNVC-ECGASQLSVDFHKDKSPLKSGET 791
Query: 610 LHRGCILCDELLHSLVEMKH 629
+ GCI CDELL SLV +KH
Sbjct: 792 KYEGCIFCDELLSSLVSLKH 811
>D8TJM6_VOLCA (tr|D8TJM6) DNA topoisomerase OS=Volvox carteri GN=VOLCADRAFT_79203
PE=3 SV=1
Length = 896
Score = 636 bits (1640), Expect = e-179, Method: Compositional matrix adjust.
Identities = 333/693 (48%), Positives = 433/693 (62%), Gaps = 34/693 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCV+R+ I +F+PE FWSV P +G ++LEW + ++FD
Sbjct: 208 LDASVISYGPCQTPTLNFCVERHQAIVSFQPEPFWSVRPRASKAGTPLELEWDKGRVFDQ 267
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+V +F LV E L V ++ EK++ K RP GLNTV LLKVAS++LG GP AMQ+AER
Sbjct: 268 DVGALFASLVREAKRLRVVDVVEKEDRKQRPHGLNTVELLKVASASLGMGPAHAMQIAER 327
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYT G++SYPRTES+AYPP+FD G ++A N+P +G Y LL G P+ GTDVGDH
Sbjct: 328 LYTAGYLSYPRTESSAYPPNFDITGTVAALRNHPVFGGYASALLQQGVKHPQGGTDVGDH 387
Query: 187 PPITPMRPAAEDML-GNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
PPITP+R A ED L G DAW++Y ++ +HF+G+VSPD Y + K F GE+F +G
Sbjct: 388 PPITPVRAATEDDLGGGDAWRVYDFVTRHFLGSVSPDAVYRKTKATFEGDGETFSASGSV 447
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
V+ +GFTAIMPW A + +P G+ + +S +ELY+G T+PPDYLTES+LI LMEK+G
Sbjct: 448 VVRQGFTAIMPWRATQSEPLPPLTPGEYLPLSDLELYQGRTSPPDYLTESDLIGLMEKHG 507
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNICERNYV +Q+GR++VPT LGITL+RGYQ IDP+LC P + + E +
Sbjct: 508 IGTDASIPVHINNICERNYVTIQSGRRVVPTELGITLIRGYQLIDPELCKPQVGAGGEGR 567
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGR-ILSKCGK 424
G + + + + + K + + + ++ F L R + +KCGK
Sbjct: 568 GGGQPAGV----SMCEELNRDVEGKSSFPLSFVTSLGFSFSLDCFPLASVIRFVRTKCGK 623
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQK---------GTIKLYKELSCPLDNFELLLCS 475
C RYMKYISA+P RLYC CEEV LPQ G ++LYK L CPLD +ELLL S
Sbjct: 624 CRRYMKYISARPQRLYCNTCEEVLALPQARGGGCFFFPGLVRLYKSLVCPLDGYELLLFS 683
Query: 476 M-GPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKG-----AGMPCILCPHPTC 529
+ G DGK++PLCP+CY+NPPFEG+ + K G+ KG AGMPC C HPTC
Sbjct: 684 LSGSDGKTYPLCPFCYNNPPFEGVLKVGGWGKGDGEGRKRKGAPGGKAGMPCSTCTHPTC 743
Query: 530 PNSLVSQGVCACPE--CS-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTT-KERC 585
P+SL S GV CP CS GT+VLDPVSAPKWRL CN CN L++L H KE C
Sbjct: 744 PHSLASNGVFPCPNPGCSGGTVVLDPVSAPKWRLDCNRCNFLMYLPPNLHSAKVLPKETC 803
Query: 586 PECDSSIIEVDFNKKATP------LEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXX 639
+C ++++D+ K P E GS + C++CDE + L E+KH
Sbjct: 804 EDCGGRLLDLDWKKGQLPPSLAAEAEGGSLVSGVCVVCDEEVAKLCEVKHGHAFAARRMG 863
Query: 640 XXXXXXXXXXXXXXXXXXXM---VDPKMSFRDF 669
DP+MSFRDF
Sbjct: 864 PRGRGGRGRGRRGRGRGRGRDKNYDPRMSFRDF 896
>B7Q7K8_IXOSC (tr|B7Q7K8) Topoisomerase I, putative OS=Ixodes scapularis
GN=IscW_ISCW010954 PE=3 SV=1
Length = 857
Score = 630 bits (1624), Expect = e-178, Method: Compositional matrix adjust.
Identities = 302/622 (48%), Positives = 411/622 (66%), Gaps = 20/622 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + + S+GPCQTPTLGFCV R+ +I +FKPE +W + V + L+W+R ++FD
Sbjct: 207 LDSSFISFGPCQTPTLGFCVDRHDKIQSFKPEAYWVLQ-VKVSNEQTFTLDWERGRIFDR 265
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
VA +F ++ +T++++K+++K RPV LNTV L+++ASS LG GPH AMQ+AER
Sbjct: 266 EVAMVFLTQISNCKEALITDVTQKEKSKPRPVALNTVELMRIASSGLGMGPHHAMQVAER 325
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY QG+ISYPRTE+T+YP +FD RG L P V+ LL+ G +P+ G D GDH
Sbjct: 326 LYIQGYISYPRTETTSYPENFDLRGTLHQIQRVPDLSADVQELLSKGINRPKKGHDAGDH 385
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITP + A+ L DAW+LY YI +HF+ T+S D K+ + F++G E F TG+ V
Sbjct: 386 PPITPTKDASRGELDGDAWRLYDYIARHFVATLSEDMKFLQATASFTVGEERFSLTGKSV 445
Query: 247 ITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
I GFT M W A+ ++ +P G V +++L E T+PP YLTESELISLM+K+G
Sbjct: 446 INPGFTKFMSWHAVTPEEALPQLKAGTTCPVVQMKLSEQKTSPPGYLTESELISLMDKHG 505
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINN+C+RNYV V +GR+L+PT LGI LV GYQ ID DL LP +R+ +EQQ
Sbjct: 506 IGTDASIPVHINNVCQRNYVTVDSGRRLIPTNLGIVLVHGYQKIDTDLILPTMRAAVEQQ 565
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ LIA G+ D+ V+ H + F+ KFCYFV I MD LFE F+ L +SGR LS+CGKC
Sbjct: 566 LNLIAVGKADYDAVLSHTLTVFQLKFCYFVTSILQMDELFEVTFTPLSESGRPLSRCGKC 625
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RY+K ++++PSRL+C C + + +PQ G+++ ++EL CPLD+FELL G GKSF
Sbjct: 626 RRYLKLVASKPSRLHCVQCNDTHSIPQNGSVRTFRELKCPLDDFELLQWYGGTKGKSFIF 685
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF T +IG C C HPTCP+S+++ G+ CPEC
Sbjct: 686 CPYCYNHPPFR-----------DTGHQIG------CNSCTHPTCPHSMMANGISVCPECT 728
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
SG LVLDP SAPKW++ CN C+ +V L + A ++S E+C EC S +I V++ + T L
Sbjct: 729 SGVLVLDPASAPKWKIGCNRCDVIVQLCEDARKVSVEDEQCEECGSQVISVEYKLEKTKL 788
Query: 605 EDGSTLHRGCILCDELLHSLVE 626
T GCI CD L LVE
Sbjct: 789 PGAQTEAAGCIFCDVTLSCLVE 810
>L5KVZ8_PTEAL (tr|L5KVZ8) DNA topoisomerase OS=Pteropus alecto
GN=PAL_GLEAN10010851 PE=3 SV=1
Length = 779
Score = 626 bits (1614), Expect = e-176, Method: Compositional matrix adjust.
Identities = 306/626 (48%), Positives = 408/626 (65%), Gaps = 50/626 (7%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 154 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 213
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S+K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 214 REIAQMFLNMTKMEKEAQVEATSKKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 273
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W + V+ LL+
Sbjct: 274 RLYTQGYISYPRTETTHYPENFDLKGLLRQQANHPYWADTVKQLLSE------------- 320
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
G +AW LY+YI +HFI TVS DCKY + + F IG E F CTG+
Sbjct: 321 ---------------GGEAWWLYEYITRHFIATVSYDCKYLQSTISFRIGPEHFTCTGKT 365
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI+ GFT IMPW +I ++++P+ +G V ++++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 366 VISPGFTEIMPWQSIPLEESLPTCQRGDTFPVGEMKMLEKQTSPPDYLTEAELITLMEKH 425
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GI DASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 426 GI--DASIPVHINNICQRNYVVVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 483
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 484 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 543
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 544 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 603
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 604 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 646
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
+G LVLDP S PKW++ CN CN + + AHR+ + E C C++++++VDFNK +P
Sbjct: 647 ENGVLVLDPTSGPKWKMACNKCNVVAHCFENAHRVRVSSETCSSCEAALLDVDFNKAKSP 706
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 707 LPGDETQHTGCVFCDPVFQELVELKH 732
>B6KLI4_TOXGO (tr|B6KLI4) DNA topoisomerase OS=Toxoplasma gondii GN=TGME49_064450
PE=3 SV=1
Length = 841
Score = 625 bits (1613), Expect = e-176, Method: Compositional matrix adjust.
Identities = 306/624 (49%), Positives = 406/624 (65%), Gaps = 23/624 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQRY I+ F+PE F++++ I E+ LEW+R ++FD
Sbjct: 189 LDASLVSYGPCQTPTLQFCVQRYDDIHAFQPETFYTLDTSIRVGEQELFLEWERGQVFDS 248
Query: 67 NVATMFQKLVAEDGLLEVT-EISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
A ++ +V+ G + V +++EK+E RP LNTVN+LK+AS LG GP AMQ AE
Sbjct: 249 VTAHTYKDIVSARGAVAVVVDVTEKEEKMPRPQALNTVNMLKLASQRLGMGPQQAMQTAE 308
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLY G ++YPRTE+ YP SFD RG +AQA+NP WG YV+ LL++G +PR G D GD
Sbjct: 309 RLYLSGKVTYPRTETCKYPESFDLRGTAAAQASNPYWGGYVKELLSSGLARPRDGVDAGD 368
Query: 186 HPPITPMRPAAE-DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPITP+ A E D+ G DAW LY+ I +HF+ ++SPDC++ +RKV F + E F +G+
Sbjct: 369 HPPITPVCSATEADVGGGDAWALYELITRHFLASISPDCRFLKRKVTFCVNEEIFSLSGR 428
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
H++ GFT IM + D +IP F K ++ + K+ + G T PP +L+ES+L+ LMEK+
Sbjct: 429 HMLDGGFTRIMRGDGMKDVSIPDFRKADQVPLHKISVGSGQTHPPPFLSESDLLGLMEKH 488
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDAS+ HINNICERNYV + + R+L PT LG+ LV GY IDPDL LP +R+ IE
Sbjct: 489 GIGTDASMATHINNICERNYVSLVSNRRLEPTKLGVCLVHGYMQIDPDLVLPSVRASIEA 548
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+ +IA+G+ D VV H + FK KF YF+K+IE MD LFEA F+ L +G LS+CG+
Sbjct: 549 LVDVIAQGKADITAVVTHSLYMFKLKFAYFLKQIERMDMLFEASFTMLAQTGNALSRCGR 608
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYM I+ +P+RL+C C E Y +PQ G IKLYKEL CPLDNFEL+L + GKSFP
Sbjct: 609 CNRYMNLITKRPTRLHCRTCNETYNMPQNGAIKLYKELRCPLDNFELVLFTQ-KGGKSFP 667
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC--P 542
LCP CY++PP E G M C+ C HPTC + + + GV C P
Sbjct: 668 LCPLCYNDPPLE-----------------GSVTKMSCVECTHPTCKHGIEAVGVLQCPQP 710
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
+C G L LD VS PKW+L CN C V L +GAH+IS T + C C S+++ V N K
Sbjct: 711 DCKGILYLDVVSGPKWKLDCNACQYQVKLMEGAHKISVTPDECDTCGSALLNVVMN-KVK 769
Query: 603 PLEDGSTLHRGCILCDELLHSLVE 626
P +DG GC +CD L+ +VE
Sbjct: 770 PFKDGEVEKTGCFVCDAELNDMVE 793
>B9QEY2_TOXGO (tr|B9QEY2) DNA topoisomerase OS=Toxoplasma gondii GN=TGVEG_081720
PE=3 SV=1
Length = 842
Score = 620 bits (1600), Expect = e-175, Method: Compositional matrix adjust.
Identities = 306/625 (48%), Positives = 405/625 (64%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFD 65
L A SYGPCQTPTL FCVQRY I+ F+PE F++V + E+ LEW+R ++FD
Sbjct: 189 LDASLVSYGPCQTPTLQFCVQRYDDIHAFQPETFYTVCKSVFDLREQELFLEWERGQVFD 248
Query: 66 INVATMFQKLVAEDGLLEVT-EISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
A ++ +V+ G + V +++EK+E RP LNTVN+LK+AS LG GP AMQ A
Sbjct: 249 SVTAHTYKDIVSARGAVAVVVDVTEKEEKMPRPQALNTVNMLKLASQRLGMGPQQAMQTA 308
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLY G ++YPRTE+ YP SFD RG +AQA+NP WG YV+ LL++G +PR G D G
Sbjct: 309 ERLYLSGKVTYPRTETCKYPESFDLRGTAAAQASNPYWGGYVKELLSSGLARPRDGVDAG 368
Query: 185 DHPPITPMRPAAE-DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTG 243
DHPPITP+ A E D+ G DAW LY+ I +HF+ ++SPDC++ +RKV F + E F +G
Sbjct: 369 DHPPITPVCSATEADVGGGDAWALYELITRHFLASISPDCRFLKRKVTFCVNEEIFSLSG 428
Query: 244 QHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+H++ GFT IM + D +IP F K ++ + K+ + G T PP +L+ES+L+ LMEK
Sbjct: 429 RHMLDGGFTRIMRGDGMKDVSIPDFRKADQVPLHKISVGSGQTHPPPFLSESDLLGLMEK 488
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDAS+ HINNICERNYV + + R+L PT LG+ LV GY IDPDL LP +R+ IE
Sbjct: 489 HGIGTDASMATHINNICERNYVSLVSNRRLEPTKLGVCLVHGYMQIDPDLVLPSVRASIE 548
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+ +IA+G+ D VV H + FK KF YF+K+IE MD LFEA F+ L +G LS+CG
Sbjct: 549 ALVDVIAQGKADITAVVTHSLYMFKLKFAYFLKQIERMDMLFEASFTMLAQTGSALSRCG 608
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
+C RYM I+ +P+RL+C C E Y +PQ G IKLYKEL CPLDNFEL+L + GKSF
Sbjct: 609 RCNRYMNLITKRPTRLHCRTCNETYNMPQNGAIKLYKELRCPLDNFELVLFTQ-KGGKSF 667
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC-- 541
PLCP CY++PP E G M C+ C HPTC + + + GV C
Sbjct: 668 PLCPLCYNDPPLE-----------------GSVTKMSCVECTHPTCKHGIEAVGVLQCPQ 710
Query: 542 PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKA 601
P+C G L LD VS PKW+L CN C V L +GAH+IS T + C C S+++ V N K
Sbjct: 711 PDCKGILYLDVVSGPKWKLDCNACQYQVKLMEGAHKISVTPDECDTCGSALLNVVMN-KV 769
Query: 602 TPLEDGSTLHRGCILCDELLHSLVE 626
P +DG GC +CD L+ +VE
Sbjct: 770 KPFKDGEVEKTGCFVCDAELNDMVE 794
>B3RKZ5_TRIAD (tr|B3RKZ5) Putative uncharacterized protein OS=Trichoplax
adhaerens GN=TRIADDRAFT_49643 PE=3 SV=1
Length = 841
Score = 618 bits (1594), Expect = e-174, Method: Compositional matrix adjust.
Identities = 291/625 (46%), Positives = 409/625 (65%), Gaps = 22/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ +IN+F+PEK+W ++ + H+ L+W R ++FD
Sbjct: 204 LDSSLISYGPCQTPTLGFCVERHDKINSFEPEKYWKIDVKVRHNNSTFALQWNRVRIFDK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
NVA+MF + + ++ +++ Q++K +P+ LNTV +L+ ASS L GPH M LAER
Sbjct: 264 NVASMFCEDIKAVTRTKILKVTTTQKSKQKPIALNTVEMLRKASSGLNIGPHHTMALAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY QG+ISYPRTE+T YP +FDFR L +++ G+ V+ LL +GY KP+ G D GDH
Sbjct: 324 LYIQGYISYPRTETTTYPQNFDFRDLLGKLSSHEDLGDTVKSLLKDGYSKPKKGQDAGDH 383
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ A + L D+W+LY YI +H++G+V DC+Y + I ESF C+G V
Sbjct: 384 PPITPMKVAGRNELSGDSWRLYDYIVRHYLGSVMEDCRYTQTTYMVEISKESFTCSGAVV 443
Query: 247 ITKGFTAIMPWLAIND-KNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GF ++M WL ++ +N+P+ +G +E+++ +L E T+PPDYLTESELI+LMEK+G
Sbjct: 444 TSPGFLSVMNWLQQDEGQNLPNLDRGAVLEITEAKLSEHQTSPPDYLTESELITLMEKHG 503
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNICERNYV++ R+L PT LGI L+ GY ID DL LP +R+ +E+Q
Sbjct: 504 IGTDASIPVHINNICERNYVKITGSRRLQPTQLGIVLIHGYHKIDSDLALPTMRADVEKQ 563
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ LIA G+ D VV +V+ F+ KFCYF + MD LFE F+ L ++G+ +CG C
Sbjct: 564 LNLIAAGKADFKAVVNYVVDIFRNKFCYFKDSVSNMDHLFEVCFTKLAETGKPFCRCGSC 623
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGP-DGKSFP 484
RYMK I A+PSRLYC C++ Y LPQ GTIKLYKEL CP+D+FEL+L S K+ P
Sbjct: 624 NRYMKLIVAKPSRLYCKTCDQTYSLPQNGTIKLYKELKCPIDDFELVLFSANTGTAKAVP 683
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCP CY+ P+ + + C C HPTCP+S++ + C C
Sbjct: 684 LCPACYTKSPYPDV-----------------AKNLMCNQCLHPTCPHSMMQNRILDCQIC 726
Query: 545 S-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G++VLD SAPKWR+ CN C V L Q A ++S +E C C ++II ++F K +P
Sbjct: 727 DQGSIVLDAPSAPKWRMTCNKCKFFVPLLQNASKVSVKEETC-HCPTNIITIEF-KDESP 784
Query: 604 LEDGSTLHRGCILCDELLHSLVEMK 628
+G H GC+ CDE+ L++++
Sbjct: 785 FPNGKKSHSGCLNCDEIFVKLIKLE 809
>M7BQV0_CHEMY (tr|M7BQV0) DNA topoisomerase 3-beta-1 OS=Chelonia mydas
GN=UY3_02434 PE=4 SV=1
Length = 677
Score = 618 bits (1593), Expect = e-174, Method: Compositional matrix adjust.
Identities = 304/626 (48%), Positives = 396/626 (63%), Gaps = 69/626 (11%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSG-YEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + H + LEW R ++FD
Sbjct: 71 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNHEKESSLTLEWDRVRVFD 130
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + +V +S+K++ K RP+ LNTV +L+VAS+ALG GP MQ+AE
Sbjct: 131 REIAQMFLNITKMAREAKVESVSKKEKAKQRPLALNTVEMLRVASAALGMGPQHTMQIAE 190
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD + L QANNP W V+ LL+ G +PR G D GD
Sbjct: 191 RLYTQGYISYPRTETTHYPENFDLKEPLRQQANNPYWAETVKALLSEGVNRPRKGHDAGD 250
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A E L
Sbjct: 251 HPPITPMRAATEAEL--------------------------------------------- 265
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
GFT IMPW +I ++++P+ KG VS+V+L E T PPDYLTE+ELI+LMEK+
Sbjct: 266 ----GFTEIMPWQSIPLEESLPNCEKGDIFPVSEVKLLEKQTNPPDYLTEAELITLMEKH 321
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 322 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 381
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ ++ +V++H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 382 QLNLIAQGKANYQQVLEHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 441
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 442 CHRFMKYIQAKPSRLHCSHCDETYSLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 501
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ GM C C HPTC +SL G+ C EC
Sbjct: 502 LCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIGQCVEC 544
Query: 545 -SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
+G LVLDP S PKW++ CN CN +V + AH++ + E C CD+++++VDFNK +P
Sbjct: 545 ENGVLVLDPTSGPKWKMACNKCNVIVHFFENAHKVRVSPETCESCDAALVDVDFNKAKSP 604
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
L T H GC+ CD + LVE+KH
Sbjct: 605 LPGDETQHSGCVFCDPVFQDLVELKH 630
>H3B0D1_LATCH (tr|H3B0D1) DNA topoisomerase OS=Latimeria chalumnae PE=3 SV=1
Length = 863
Score = 617 bits (1592), Expect = e-174, Method: Compositional matrix adjust.
Identities = 298/628 (47%), Positives = 402/628 (64%), Gaps = 22/628 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPELYWVIQAKVSDGKAVSLTLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA MF ++ +V +S+K++ K RP+ LNTV +L+VAS+ALG GP MQ+AE
Sbjct: 267 REVAQMFLNIIKVVKEAKVESVSKKEKVKQRPLALNTVEMLRVASAALGMGPQHTMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T Y +FD +G L QAN+ W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYAENFDLKGVLRQQANSSYWADTVKALLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+E LG+D W+LY+YI +HFI TVS DCKY + + FSIG E F TG+
Sbjct: 387 HPPITPMRAASEAELGSDGWRLYEYITRHFIATVSYDCKYLQTTILFSIGKERFTSTGKM 446
Query: 246 VIT--KGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTT-PPDYLTESELISLME 302
VI+ GF I+ + + ++ + P + ++++ ++
Sbjct: 447 VISPGGGFKIILSEEVVCEMSVSEACSCHLPLPLLKLNLLEILSLAPGFSMYNDVLRVLI 506
Query: 303 KNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
G GTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +
Sbjct: 507 PGGGGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDSELVLPTIRSAV 566
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E+Q+ LIA+G+ ++ +V++H + FK+KF YFV I MD L E FS L +G+ LS+C
Sbjct: 567 EKQLNLIAQGKANYRQVLEHGLDIFKRKFHYFVDSITDMDELMEVSFSPLAATGKPLSRC 626
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL CPLD FEL+L S G GKS
Sbjct: 627 GKCHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELRCPLDEFELVLWSSGSRGKS 686
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+PLCPYCY++PPF ++ GM C C HPTC +SL G+ C
Sbjct: 687 YPLCPYCYNHPPFRDMK-----------------KGMGCNECTHPTCQHSLSMLGIAQCV 729
Query: 543 EC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKA 601
EC +G LV DP S PKW++ CN CN + + AH++ + E C C++++++VDFNK
Sbjct: 730 ECENGVLVFDPTSGPKWKMACNKCNVVAHFFENAHKVKVSPENCESCEAALVDVDFNKAK 789
Query: 602 TPLEDGSTLHRGCILCDELLHSLVEMKH 629
TPL +G T H GC CD + LVE+KH
Sbjct: 790 TPLPEGETQHVGCAFCDPVFQDLVELKH 817
>B0WQT7_CULQU (tr|B0WQT7) DNA topoisomerase OS=Culex quinquefasciatus
GN=CpipJ_CPIJ009756 PE=3 SV=1
Length = 855
Score = 617 bits (1592), Expect = e-174, Method: Compositional matrix adjust.
Identities = 310/627 (49%), Positives = 406/627 (64%), Gaps = 25/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL CVQR+ +I TFKPE FW V V EI+L+W R ++F+
Sbjct: 205 LDASLISYGPCQTPTLTLCVQRHDEIQTFKPESFWYVQ-VTVGENPEIKLDWSRVRIFEK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
VA MF V + V +S K+ K RP LNTV L++ AS+ LG GPH AMQ+AE+
Sbjct: 264 EVACMFLNKVKDHKEAIVENVSSKEAFKGRPQALNTVELMRAASAGLGIGPHSAMQIAEK 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYT+G+ISYPRTE+T YP +FD G + ++ +G+ + +L + PR G D GDH
Sbjct: 324 LYTRGYISYPRTETTQYPTNFDLVGVVKLLQHSSEFGDEAKSIL-HDMNSPRKGNDAGDH 382
Query: 187 PPITPMRPAAEDML-GNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
PPITPM+ A+ + L G D +++Y YIC+HF+ TVS D KY + +F IG E F T
Sbjct: 383 PPITPMKLASRNELDGGDTFRVYDYICRHFLATVSRDLKYRQTSTKFKIGSEHFSNTSNV 442
Query: 246 VITKGFTAIMPW--LAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+I G+T +M W A N+ +P FI +K++++ V L E T PPDYLTESELISLMEK
Sbjct: 443 LIDPGYTKVMTWQAFAKNELVVP-FIVNEKVKINDVRLVESQTGPPDYLTESELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV + GR L PT LGI LV GYQ IDP+L LP +RS +E
Sbjct: 502 HGIGTDASIPVHINNICQRNYVAIGGGRTLTPTNLGIVLVHGYQKIDPELVLPTMRSAVE 561
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
QQ++LIA G D+ V++H ++ F+ KF YFV+ I MD LFEA FS+L SG+ LS+CG
Sbjct: 562 QQLSLIAHGSADYRSVLKHAVEIFRLKFLYFVQNISNMDILFEATFSSLSSSGKALSRCG 621
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC RYMKYI ++PSRL+C C+E Y +P KG +++Y+EL CPLD+FELL S G GKS+
Sbjct: 622 KCRRYMKYIQSKPSRLHCSTCDETYTMPVKGVVRVYRELKCPLDDFELLAWSNGAKGKSY 681
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYCY++PPF + K +G C CPHPTC +SL GV +C E
Sbjct: 682 PLCPYCYNHPPFR---------------DMAKNSG--CNSCPHPTCAHSLTLLGVSSCIE 724
Query: 544 CS-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G LVLD S+PKW+L CN C+ ++ A +++ E C EC + + + + T
Sbjct: 725 CDRGILVLDCTSSPKWKLVCNFCDVIINCFDDAVKVNVEAESCDECGAQQVTAIYKTEKT 784
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
P +D T +GCI C LVE KH
Sbjct: 785 PFKDDITEKKGCIFCFPDFVPLVE-KH 810
>Q16PL8_AEDAE (tr|Q16PL8) DNA topoisomerase OS=Aedes aegypti GN=AAEL011603 PE=3
SV=1
Length = 856
Score = 616 bits (1588), Expect = e-174, Method: Compositional matrix adjust.
Identities = 311/627 (49%), Positives = 402/627 (64%), Gaps = 24/627 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I TFKPE FW V V EI+LEW R ++F+
Sbjct: 205 LDASLISYGPCQTPTLGFCVQRHDEIQTFKPESFWYVQ-VTVGENPEIKLEWSRVRIFEK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
VA MF V + V ++ K+ +SRP LNTV L++ AS+ LG GPH AMQ+AE+
Sbjct: 264 EVACMFLNKVKDQKEALVESVTSKETFRSRPQALNTVELMRAASAGLGIGPHTAMQIAEK 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYT+G+ISYPRTE+T YP +FD G + + +G +L + PR G D GDH
Sbjct: 324 LYTRGYISYPRTETTQYPTNFDLVGVVKLLQPSSEFGEEARDILRD-MSSPRKGNDAGDH 382
Query: 187 PPITPMRPAAEDML-GNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
PPITPM+ A+ + L G D W+LY YIC+HF+GT+S D KY +F I E F T
Sbjct: 383 PPITPMKLASRNELDGGDTWRLYDYICRHFLGTISRDLKYRLTTTKFKINNELFTNTSSV 442
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I G+T +M W A N ++ I F +K++++ V L E T PPDYLTESELISLMEK+
Sbjct: 443 LIDPGYTKVMTWQAFNKNEVITPFTVNEKVKINDVRLVESQTGPPDYLTESELISLMEKH 502
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV + GR L PT LGI LV GY+ IDP+L LP +RS +EQ
Sbjct: 503 GIGTDASIPVHINNICQRNYVAIGGGRTLTPTNLGIVLVHGYRKIDPELVLPTMRSAVEQ 562
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA G D+ V++H ++ F+ KF YFV+ I MD LFEA FS+L SG+ LS+CGK
Sbjct: 563 QLNLIAHGSADYRLVLKHAVEIFRLKFLYFVQNISNMDILFEATFSSLCSSGKALSRCGK 622
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYMKYI +P+RL+C C+E Y +P KG +++Y+EL CPLD+FELL S G GKS+P
Sbjct: 623 CRRYMKYIQTKPARLHCSQCDETYTMPTKGIVRVYRELKCPLDDFELLAWSNGAKGKSYP 682
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY+ PPF + K +G C CPHPTC +SL S GV +C EC
Sbjct: 683 LCPYCYNYPPFRDMP---------------KNSG--CNSCPHPTCAHSLSSLGVSSCIEC 725
Query: 545 S-GTLVLDPVSAPK-WRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
G LVLD +PK WRL CN C+ ++ A +++ + C EC + + + + T
Sbjct: 726 DRGVLVLDCTMSPKSWRLVCNFCDVIINCFDDAVKVNVEGDSCEECGAQQVTAIYKAEKT 785
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMKH 629
P +D T +GCI C E LVE KH
Sbjct: 786 PFKDDVTDKKGCIFCFEDFIPLVE-KH 811
>K8YSM6_9STRA (tr|K8YSM6) DNA topoisomerase OS=Nannochloropsis gaditana CCMP526
GN=TOP3 PE=3 SV=1
Length = 870
Score = 613 bits (1582), Expect = e-173, Method: Compositional matrix adjust.
Identities = 322/697 (46%), Positives = 411/697 (58%), Gaps = 53/697 (7%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I +F PEKFW + + G + LEW R ++FD
Sbjct: 193 LDATLVSYGPCQTPTLGFCVQRHDEIQSFSPEKFWYLAAAVAKDGANVALEWGRGRVFDH 252
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
VA +F LV E G + V ++ + ++ +++P LNTV LLK AS LG GP M +AER
Sbjct: 253 EVAHVFLHLVGEAGSVAVDKVQKSEQRRTKPTALNTVELLKEASKVLGMGPAQTMSVAER 312
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY G++SYPRTESTAYP SFD RGALS Q ++PTWG+Y +GLL G +PR G D GDH
Sbjct: 313 LYLSGYLSYPRTESTAYPESFDVRGALSLQVSHPTWGDYAKGLLQEGVSRPRAGVDAGDH 372
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIG-GESFHCTGQH 245
PPITP+R D +LY + +HF+ ++S D ++ + KV FS GESF +G+
Sbjct: 373 PPITPVRALDPTEFPGDMGRLYDLVTRHFLASLSHDARFLQTKVLFSSECGESFSASGKI 432
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+I G+ A++ + ++ +P F +G S + L +G T+PP YLTESELI MEK+G
Sbjct: 433 MIDPGYLAVLAQ-SKDESKLPDFQEGDHFTFSSLGLGDGHTSPPGYLTESELIERMEKHG 491
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVP-------TTLGITLVRGYQSIDPDLCLPDI 358
IGTDASI HINNI ERNYV V GR L+P LGI LV GY ID DL LP +
Sbjct: 492 IGTDASISSHINNIVERNYVHVGDGRTLIPNPLGDCGNILGIVLVHGYLRIDADLVLPKV 551
Query: 359 RSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRI 418
R+ IE + TLIAKGQ D VV H ++ F+ KF YF + I+ MD+LFEA FS L +G+
Sbjct: 552 RAQIESECTLIAKGQADMQSVVDHSLRNFEAKFRYFAEHIDLMDSLFEATFSPLAATGKP 611
Query: 419 LSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-- 476
LS+CGKC R+MKYI +P RLYC IC E Y LPQ GTIKLYKEL CPLD+FELLL S+
Sbjct: 612 LSRCGKCRRFMKYIHLKPQRLYCPICNETYALPQNGTIKLYKELKCPLDDFELLLFSLGN 671
Query: 477 --GPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLV 534
G GKSFPLCPYCYS+PPFEG+ M C C HPTC +SL
Sbjct: 672 AQGAQGKSFPLCPYCYSHPPFEGLSI------------------MGCDSCMHPTCKHSLT 713
Query: 535 SQGVCACP-----ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRIST----TKERC 585
GVC CP C GTLVLD S P W++ CN CN LV I + T + C
Sbjct: 714 RNGVCPCPGESGAACPGTLVLDVNSYPNWKMACNRCNNLVLFKVTGGNIHSIKPATSQYC 773
Query: 586 PECDSSIIEVDFNKKATPLE--------DGSTLHRGCILCDELLHSLVEM-----KHXXX 632
C S+++ +++ K +PL G T GC+LC ++L++ E+ KH
Sbjct: 774 EVCGSAVLTIEYQKDKSPLSGEEGRFCAGGETKIEGCVLCHDILNTCTELAKGRHKHVAI 833
Query: 633 XXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
+P MSF DF
Sbjct: 834 ARKDFAKRNRGRGRGRGRGRGRGGKGGANPLMSFEDF 870
>B4L687_DROMO (tr|B4L687) DNA topoisomerase OS=Drosophila mojavensis
GN=Dmoj\GI16324 PE=3 SV=1
Length = 858
Score = 609 bits (1571), Expect = e-171, Method: Compositional matrix adjust.
Identities = 295/625 (47%), Positives = 401/625 (64%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I FKPE FW + +V E+ LEW R ++F
Sbjct: 205 LDSSLISYGPCQTPTLGFCVKRHDDIQLFKPETFWYLQ--LVAGQPEVTLEWARGRVFKK 262
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
N+A M V E V +S K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 263 NIAIMLLNRVKEHKEATVESVSSKESFKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 322
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G+ + ++ + PR G D GDH
Sbjct: 323 LYTQGYISYPRTETNQYPENFDLHAVLRLLQPSGDFGDEARAI-SSDFQTPRKGKDAGDH 381
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ + D W++Y++IC+HF+GT+S D KY + +G E+F CT +
Sbjct: 382 PPITPMKLGHRNDFDRDTWRVYEFICRHFMGTISRDLKYRTTTAKLKVGLETFTCTANVL 441
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT +M W A D+ +P F++G ++ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 442 LDAGFTKVMTWQAFGKDEAMPPFVQGTQVPITDVRLAESQTGPPDYLTEAELITLMEQHG 501
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GYQ IDP+L LP +RS +E+
Sbjct: 502 IGTDASIPVHINNICQRNYVKIETGRKLIPTTLGIVLVHGYQKIDPELVLPTMRSEVERM 561
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIAKG D + V++H I+ FK KF YFV+ I +MD LFE+ FS L +SG+ S+CGKC
Sbjct: 562 LTLIAKGSADFNDVLRHAIKIFKLKFVYFVQNIASMDMLFESSFSPLAESGKAHSRCGKC 621
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RLYC CE+ Y LP G +K+Y+E CPLD+F LL S G G+SF
Sbjct: 622 RRYMKYIQTKPARLYCSHCEDNYTLPN-GNVKVYREFKCPLDDFGLLAFSTGVKGRSFAF 680
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + K G C C HPTCP+SL + G+ +C EC
Sbjct: 681 CPYCYNHPPFRDMP------------KFGG-----CNTCTHPTCPHSLNTLGISSCVECE 723
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD +P W+L CN C+ ++ +GA +I+ + +C EC + ++ V + +
Sbjct: 724 TGVLVLDSTLSPTWKLGCNRCDVIINCFKGATKITVEENKCSECGAQLVNVVYKSDKSKF 783
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GC+ C LVE KH
Sbjct: 784 KDGSEEKSGCVFCSSEFAHLVE-KH 807
>Q29HK8_DROPS (tr|Q29HK8) DNA topoisomerase OS=Drosophila pseudoobscura
pseudoobscura GN=Dpse\GA17464 PE=3 SV=2
Length = 875
Score = 609 bits (1571), Expect = e-171, Method: Compositional matrix adjust.
Identities = 296/625 (47%), Positives = 399/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWYLQ--MLAGQPEFTLEWGRGRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V +S K+ KS+P+ LNTV L+++ SS LG GP AMQ+AER
Sbjct: 264 DIAIMLLNRVKEHKEATVESVSSKEAFKSKPLALNTVELMRICSSGLGIGPFQAMQIAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG++SYPRTE+ YP +FD L + +G+ +L + PR G D GDH
Sbjct: 324 LYTQGYVSYPRTETNQYPENFDLPAVLRVLQPSGDFGDEARSILGD-IQAPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ A D W++Y++IC+HF+GT+S D KY + +G E+F CT +
Sbjct: 383 PPITPMKLANRSDFDRDTWRVYEFICRHFMGTLSRDLKYRTTTAKLKVGMETFSCTANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ +G+T +M WLA D+ +P F++G ++ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 443 LDQGYTKVMTWLAFGRDEPMPPFVQGTQVAINDVRLAESQTGPPDYLTEAELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GY IDP+L LP +RS +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVRIENGRKLIPTTLGIVLVHGYTKIDPELVLPTMRSEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIAKG D V+QH I FK KF Y+VK I +MDALFE FS L +SG+ S+CGKC
Sbjct: 563 LTLIAKGSADFQDVLQHAITIFKLKFMYYVKNIASMDALFEVSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+FELL S G GKSFP
Sbjct: 623 RRYMKYIQTKPARLHCSHCDETYSLPN-GNVKVYREFKCPLDDFELLAFSTGVKGKSFPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + +L C C H TCP+SL + G+ C EC
Sbjct: 682 CPYCYNHPPFSDMPSLGG-----------------CNTCTHATCPHSLNTLGISGCVECP 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + + V + +
Sbjct: 725 TGILVLDSTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCSECGAQQVNVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DG+ GC+ C LVE KH
Sbjct: 785 KDGTEEKIGCVFCSSDFSHLVE-KH 808
>B4GXI4_DROPE (tr|B4GXI4) DNA topoisomerase OS=Drosophila persimilis
GN=Dper\GL20281 PE=3 SV=1
Length = 875
Score = 609 bits (1571), Expect = e-171, Method: Compositional matrix adjust.
Identities = 296/625 (47%), Positives = 399/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWYLQ--MLAGQPEFTLEWGRGRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V +S K+ KS+P+ LNTV L+++ SS LG GP AMQ+AER
Sbjct: 264 DIAIMLLNRVKEHKEATVESVSSKEAFKSKPLALNTVELMRICSSGLGIGPFQAMQIAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG++SYPRTE+ YP +FD L + +G+ +L + PR G D GDH
Sbjct: 324 LYTQGYVSYPRTETNQYPENFDLPAVLRVLQPSGDFGDEARSILGD-IQAPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ A D W++Y++IC+HF+GT+S D KY + +G E+F CT +
Sbjct: 383 PPITPMKLANRSDFDRDTWRVYEFICRHFMGTLSRDLKYRTTTAKLKVGMETFSCTANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ +G+T +M WLA D+ +P F++G ++ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 443 LDQGYTKVMTWLAFGRDEPMPPFVQGTQVAINDVRLAESQTGPPDYLTEAELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GY IDP+L LP +RS +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVRIENGRKLIPTTLGIVLVHGYTKIDPELVLPTMRSEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIAKG D V+QH I FK KF Y+VK I +MDALFE FS L +SG+ S+CGKC
Sbjct: 563 LTLIAKGSADFQDVLQHAITIFKLKFMYYVKNIASMDALFEVSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+FELL S G GKSFP
Sbjct: 623 RRYMKYIQTKPARLHCSHCDETYSLPN-GNVKVYREFKCPLDDFELLAFSTGVKGKSFPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + +L C C H TCP+SL + G+ C EC
Sbjct: 682 CPYCYNHPPFSDMPSLGG-----------------CNTCTHATCPHSLNTLGISGCVECP 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + + V + +
Sbjct: 725 TGILVLDSTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCSECGAQQVNVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DG+ GC+ C LVE KH
Sbjct: 785 KDGTEEKIGCVFCSSDFSHLVE-KH 808
>B4NCN9_DROWI (tr|B4NCN9) DNA topoisomerase OS=Drosophila willistoni
GN=Dwil\GK10076 PE=3 SV=1
Length = 884
Score = 609 bits (1571), Expect = e-171, Method: Compositional matrix adjust.
Identities = 299/625 (47%), Positives = 398/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWYLQ--LLAGQPEFTLEWARVRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M + V E V ++ K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 264 DIAIMLMQKVKEQKEAMVESVTSKETFKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQGFISYPRTE+ YP +FD + + +G+ + T+ PR G D GDH
Sbjct: 324 LYTQGFISYPRTETNQYPANFDLPAVVRVLQPSNEFGDDAREIATD-MQTPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ A D W++Y++IC+HF+GTVS D KY + +G E F C+ +
Sbjct: 383 PPITPMKLAQRGEFDRDTWRVYEFICRHFLGTVSRDLKYRVTTAKLKVGLECFSCSANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT +M W A D+ IP F++G K+ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 443 MDAGFTKVMTWQAFGRDEAIPPFVQGTKVAINDVRLAESQTGPPDYLTEAELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GYQ IDP+L LP +RS +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVRIENGRKLIPTTLGIVLVHGYQKIDPELVLPTMRSEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIAKG + + V++H IQ FK KF YFVK I MDALFE FS L +SG+ S+CGKC
Sbjct: 563 LTLIAKGSANFNDVLRHAIQIFKLKFMYFVKNIANMDALFEVSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+F+LL S G G+S+P
Sbjct: 623 RRYMKYIQTKPARLHCSHCDETYALPN-GNVKVYREFKCPLDDFDLLAFSTGVKGRSYPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + L C C H TCP+SL S G+ C EC
Sbjct: 682 CPYCYNHPPFSDMPYLGG-----------------CNTCTHATCPHSLNSLGISGCVECP 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +IS + +C +C + ++ V + +
Sbjct: 725 TGVLVLDSTLAPSWKLGCNRCDVIINCFKGATKISVDETKCTDCGAQLVSVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 785 KDGSEEKTGCIFCSTDFMHLVE-KH 808
>J9K7K9_ACYPI (tr|J9K7K9) Uncharacterized protein OS=Acyrthosiphon pisum PE=3
SV=1
Length = 854
Score = 609 bits (1570), Expect = e-171, Method: Compositional matrix adjust.
Identities = 292/624 (46%), Positives = 403/624 (64%), Gaps = 21/624 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFW--SVNPYIVHSGYEIQLEWQRSKLF 64
L + SYGPCQTPTLGFCVQR+ +I FKPE +W V Y G ++ L W++ + F
Sbjct: 205 LDSSLISYGPCQTPTLGFCVQRHDEIRRFKPEPYWVIQVRKYKYLDGQDVVLNWEKGRCF 264
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
+ + + + + + + V I++++++K RP+ LN+V L++ AS+ LG GPH AMQLA
Sbjct: 265 ERDASNSLLQALKKQQIATVVSITQQEKSKQRPLALNSVELMRAASTGLGMGPHHAMQLA 324
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLY QG+ISYPRTE++ Y +F+ A+ + WG + +L NG +PR G D G
Sbjct: 325 ERLYIQGYISYPRTETSHYSDNFELLPAMRTLQKSNEWGQEIRQVLNNGLTRPRNGKDCG 384
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITP A+ + L D+WKLY +I +HFI T+S DC+Y + V F IG E F +
Sbjct: 385 DHPPITPTMLASRNDLDGDSWKLYDFIVRHFIATISKDCRYYSKTVTFKIGSEMFTYNWR 444
Query: 245 HVITKGFTAIMPWLAINDKNIP-SFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+I GFTAI PW A+ + +F + +K+ + L + T+PP YLTESELIS+MEK
Sbjct: 445 TLIDAGFTAITPWKALPKNELAVNFERDEKLNIKDARLTDHMTSPPGYLTESELISMMEK 504
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNI +RNYV V GR+LVPT LGI LV GYQ ID L P +RS IE
Sbjct: 505 HGIGTDASIPVHINNISQRNYVTVATGRRLVPTNLGIVLVHGYQKIDKQLVEPTMRSTIE 564
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
Q+ LIAKG+ ++ RV++ I+ F+QK+ YFVK IEAMD+LFE F+TL SG+ LS+CG
Sbjct: 565 DQLNLIAKGEANYDRVLRQTIEAFRQKYLYFVKSIEAMDSLFEVSFTTLAASGKALSRCG 624
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC RYMK I A+PSRL+C C+E Y LPQ G I++YKEL CPLD+FEL+ S G G+S+
Sbjct: 625 KCRRYMKLIIAKPSRLHCSHCDETYNLPQNGNIRIYKELKCPLDDFELVTWSTGNKGRSY 684
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE 543
PLCPYCY+ P F ++ K +G C LC HPTCP G+ +C +
Sbjct: 685 PLCPYCYNQPAFRDMK---------------KHSG--CNLCLHPTCPQGFYVNGIASCLQ 727
Query: 544 C-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C +G LVLDP S PKW++ CN C+ + L + AH+I+ + + +C + ++++++ ++ T
Sbjct: 728 CDNGVLVLDPSSGPKWKVGCNKCDVIFHLFEDAHKITVEESKECDCGAQLLKIEYKEERT 787
Query: 603 PLEDGSTLHRGCILCDELLHSLVE 626
L GC+ C E LVE
Sbjct: 788 RLPRDLIEMTGCLFCCEEFGYLVE 811
>A9V3W6_MONBE (tr|A9V3W6) DNA topoisomerase OS=Monosiga brevicollis GN=26912 PE=3
SV=1
Length = 803
Score = 608 bits (1568), Expect = e-171, Method: Compositional matrix adjust.
Identities = 294/603 (48%), Positives = 386/603 (64%), Gaps = 34/603 (5%)
Query: 28 RYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMFQKLVAEDGLLEVTEI 87
R+ Q TF PE++W+++ + H ++ +W+R ++FD + +F V E V +
Sbjct: 198 RFFQ--TFTPERYWTIDLQLEHDSGFLRAQWERVRVFDQELGRVFTNRVQEASSARVVSV 255
Query: 88 SEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYPRTESTAYPPSF 147
SEK++ K RP LNTV L++V S+ LG GP AM +AERLY QG+ISYPRTE+TAYP +F
Sbjct: 256 SEKEKKKPRPNALNTVELMRVCSAGLGMGPQYAMAIAERLYMQGYISYPRTETTAYPENF 315
Query: 148 DFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKL 207
D L Q N+P WG V+ LL ++P+ G DVGDHPPITPMR A E LG D W++
Sbjct: 316 DLVSVLKEQQNSPNWGKEVKELLAGAMVQPKGGKDVGDHPPITPMRVAQESDLGGDDWRV 375
Query: 208 YQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWL-AINDKNIP 266
Y + +HFI T+SPDCKY + GGE F G ++ GFTA+M W+ + + +P
Sbjct: 376 YDLVTRHFIATLSPDCKYLTTTIVLDAGGEVFTIQGSRTLSPGFTAVMHWVGSAEQQTVP 435
Query: 267 SFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQ 326
S +G + + L S+LISLMEK+GIGTDASIPVHINNICERNYVQ
Sbjct: 436 SLPEGATLRIKSATL-------------SDLISLMEKHGIGTDASIPVHINNICERNYVQ 482
Query: 327 VQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQ 386
+QAGR LVPT LGI ++ GY++IDPDLCLP +R+ +E+Q+ LIAKGQ V+ H
Sbjct: 483 IQAGRTLVPTNLGIVMIHGYKTIDPDLCLPTMRAAVEKQLDLIAKGQAPFDDVLAHFKLL 542
Query: 387 FKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEE 446
F++KF +F I MD LFE F+ L +G+ LS+CGKC RYMKY+SA+P RLYC C+E
Sbjct: 543 FQRKFEFFEAFISNMDQLFEVTFTPLKSTGKQLSRCGKCNRYMKYVSAKPQRLYCPTCDE 602
Query: 447 VYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAK 506
+ LPQ G I LYKEL CPLD FELL+ + G G+++PLCPYCY+NPPFE ++
Sbjct: 603 TFALPQGGKIVLYKELRCPLDKFELLMFTTGTTGRAYPLCPYCYNNPPFEDMD------- 655
Query: 507 TSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLDPVSAPKWRLCCNMCN 566
K +G C C HPTC +SL+ GV C EC G LVLD S PKWRLCCN CN
Sbjct: 656 --------KASG--CNDCTHPTCEHSLIQLGVTQC-ECGGQLVLDASSKPKWRLCCNRCN 704
Query: 567 CLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVE 626
++ L + AH I TK C C + ++V+FNK PL+DG+ +GCI C E L LVE
Sbjct: 705 IVIRLFENAHSIKITKTPCEACGAMEVDVEFNKTKNPLKDGTLTRQGCIFCHEDLAPLVE 764
Query: 627 MKH 629
+ H
Sbjct: 765 LAH 767
>B4JK56_DROGR (tr|B4JK56) DNA topoisomerase OS=Drosophila grimshawi
GN=Dgri\GH12112 PE=3 SV=1
Length = 862
Score = 607 bits (1565), Expect = e-171, Method: Compositional matrix adjust.
Identities = 294/625 (47%), Positives = 398/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPETFWYLQ--LLAGQPEFTLEWARGRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V +S K+ +S+P LNTV L+++ SS LG GP+ AMQ AER
Sbjct: 264 DIAIMLLNRVKEHKEATVESVSSKESFRSKPQALNTVELMRICSSGLGIGPYQAMQFAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G + + + PR G D GDH
Sbjct: 324 LYTQGYISYPRTETNQYPENFDLHAVLRVLQPSSDFGEEARAIAAD-FQTPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ A + D W++Y++IC+HF+GT+S D KY + G ESF CT +
Sbjct: 383 PPITPMKLANRNEFDRDTWRVYEFICRHFLGTISRDLKYRTTTAKLRAGIESFSCTANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ G+T +M WLA D+ +P F++G ++ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 443 LDAGYTKVMTWLAFGKDEPMPPFVQGTQVAINDVRLAESQTGPPDYLTEAELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GYQ IDP+L LP +RS +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVRIETGRKLIPTTLGIVLVHGYQKIDPELVLPTMRSEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIAKG + + V++H I FK KF +FV+ I +MD LFE+ FS L +SG+ S+CGKC
Sbjct: 563 LTLIAKGSANFNDVLRHAIIIFKLKFMFFVQNIASMDMLFESSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RLYC C+E Y LP G +K+Y+E CPLD+F LL S G G+SFP
Sbjct: 623 RRYMKYIQMKPARLYCSNCDENYTLPN-GNVKVYREFKCPLDDFGLLAFSTGVKGRSFPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS 545
CPYCY++PPF + K G C C HPTCP+SL + G+ C EC
Sbjct: 682 CPYCYNHPPFRDMP------------KFGG-----CNTCTHPTCPHSLNTLGISGCVECE 724
Query: 546 -GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
G LVLD +P W+L CN C+ ++ +GA +I+ + +C +C + ++ V + +
Sbjct: 725 MGVLVLDSTLSPTWKLVCNRCDVIINCFKGATKITVEESKCSDCGAQLVNVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 785 KDGSEEKSGCIFCSNDFSHLVE-KH 808
>B4MAH9_DROVI (tr|B4MAH9) DNA topoisomerase OS=Drosophila virilis GN=Dvir\GJ15664
PE=3 SV=1
Length = 858
Score = 604 bits (1557), Expect = e-170, Method: Compositional matrix adjust.
Identities = 294/625 (47%), Positives = 398/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 205 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPETFWYLQ--LMAGQPEYTLEWARGRVFKK 262
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V +S K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 263 DIAIMLLNRVKEHKEATVESVSSKESFKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 322
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G+ + + + PR G D GDH
Sbjct: 323 LYTQGYISYPRTETNQYPENFDLHAVLRVLQPSGDFGDEARAIAGD-FQTPRKGKDAGDH 381
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ D W++Y++IC+HF+GT+S D KY + +G E F CT +
Sbjct: 382 PPITPMKLGHRGDFDRDTWRVYEFICRHFMGTISRDLKYRTTTAKLRVGLECFTCTANVL 441
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT +M W A D+ +P F++G ++ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 442 LDAGFTKVMTWQAFGKDEAMPPFVQGSQVAINDVRLAESQTGPPDYLTEAELITLMEQHG 501
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GYQ IDP+L LP +RS +E+
Sbjct: 502 IGTDASIPVHINNICQRNYVRIETGRKLIPTTLGIVLVHGYQKIDPELVLPTMRSEVERM 561
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIAKG D + V++H I+ FK KF +FV+ I +MD LFE+ FS L +SG+ S+CGKC
Sbjct: 562 LTLIAKGSADFNDVLRHAIKIFKLKFMFFVQNIASMDMLFESSFSPLAESGKAHSRCGKC 621
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RLYC C+E Y LP G +K+Y+E CPLD+F LL S G G+SFP
Sbjct: 622 RRYMKYIQTKPARLYCSHCDENYTLPN-GNVKVYREFKCPLDDFGLLAFSTGVKGRSFPF 680
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + K G C C HPTCP+SL + G+ C EC
Sbjct: 681 CPYCYNHPPFRDMP------------KFGG-----CNSCTHPTCPHSLNTLGISGCVECE 723
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD +P W+L CN C+ ++ +GA +I+ + +C +C + ++ V + +
Sbjct: 724 TGVLVLDSTLSPTWKLGCNRCDVIINCFKGATKITVEESKCSDCGAQLVNVVYKSDKSKF 783
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 784 KDGSEEKSGCIFCSTEFAHLVE-KH 807
>C1DYX0_MICSR (tr|C1DYX0) Predicted protein OS=Micromonas sp. (strain RCC299 /
NOUM17) GN=MICPUN_79081 PE=3 SV=1
Length = 861
Score = 603 bits (1554), Expect = e-169, Method: Compositional matrix adjust.
Identities = 303/637 (47%), Positives = 398/637 (62%), Gaps = 34/637 (5%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--GYEIQLEWQRSKLF 64
L A SYGPCQTPTL F VQR+L+I + PE FWS++ + + G + W+R ++F
Sbjct: 204 LDASVISYGPCQTPTLNFAVQRHLEIVSHTPEDFWSLHVEVRSTSLGKTLVTRWERERVF 263
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +V MF+ +VA D V + E +E K RP GLNTV+LLK AS+ +G G H AMQ+A
Sbjct: 264 DGDVGEMFRSMVAGDRHALVESVEETEEFKRRPPGLNTVDLLKAASAGMGMGAHRAMQVA 323
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLY QGFISYPRTESTAYPP FD +G L AQ +P WG +VE LL KPR G D G
Sbjct: 324 ERLYIQGFISYPRTESTAYPPGFDLKGTLKAQRGHPDWGEWVEELLAGSMTKPRGGKDEG 383
Query: 185 DHPPITPMRPAAEDML-GNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTG 243
DHPPITP+R A E + G +AW+LY ++ +HFI +VSPDC Y R+ GGE F +G
Sbjct: 384 DHPPITPVRSATESAVGGGEAWRLYDFVARHFIASVSPDCAYVSRRATLVAGGERFRVSG 443
Query: 244 QHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
Q VI G+T +MP A+ D + +G+ + ++ VEL +G T+PP YL+E+ELI LME+
Sbjct: 444 QTVIAPGWTTVMPHRAVEDDPLGEIERGESLPIATVELRQGATSPPPYLSEAELIGLMER 503
Query: 304 NGIGTDASIPVHINNICERNYV--QVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
NGIGTDASIP HINNI R YV Q Q GR++VPT LG+TLV+GY IDP+L LP +RS
Sbjct: 504 NGIGTDASIPTHINNIESRKYVTIQSQGGRRVVPTDLGVTLVQGYHRIDPELALPAVRSH 563
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ +IA G+ DH +V+H + QF KF FV +IE MD LFEA F SG+ SK
Sbjct: 564 VEKQLDMIATGKADHESIVRHTLAQFAAKFRNFVDQIERMDTLFEASFDPTCSSGKPFSK 623
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CG+CLRYM+ +S +P RLYC EEV LP GT+KLY C L FELLL G +
Sbjct: 624 CGRCLRYMRLVSTRPQRLYCPTQEEVLELP-AGTVKLYNNRECQLCGFELLLYQNG--DR 680
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
++P+CP+C+++PPF G T G + GA PHP + + VC C
Sbjct: 681 TYPMCPWCFNHPPFVG-------GSRPTKGLV-SGA-------PHPRAHPIVDALVVCPC 725
Query: 542 PEC----------SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTK-ERCPECDS 590
PEC G L+L+PV P+W+ C C +V L HR++ K + C C +
Sbjct: 726 PECGEDDKLKGREGGWLMLEPVGGPRWKFVCTGCALVVKLNDSVHRVTVDKLDVCGACGA 785
Query: 591 SIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEM 627
V ++K TPL G T H C+ CD+LL+S +E+
Sbjct: 786 RCPTVIYHKDRTPLAGGETAHVACLACDDLLNSSIEL 822
>B3MQ67_DROAN (tr|B3MQ67) DNA topoisomerase OS=Drosophila ananassae
GN=Dana\GF20299 PE=3 SV=1
Length = 878
Score = 599 bits (1545), Expect = e-168, Method: Compositional matrix adjust.
Identities = 292/625 (46%), Positives = 394/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWYLQ--LLAGQPEFTLEWARGRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A V E V +S K+ KS+P LNTV L+++ SS L GP AMQ+AER
Sbjct: 264 DIAITLLNRVKEQKEATVESVSSKEAFKSKPQALNTVELMRICSSGLSIGPFQAMQIAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G+ +L + PR G D GDH
Sbjct: 324 LYTQGYISYPRTETNQYPANFDLPAVLRVLQPSGEFGDEARSILGD-LQTPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ + D W++Y++IC+HF+GTVS D KY + +G E+F CT +
Sbjct: 383 PPITPMKLGSRSDFDRDTWRVYEFICRHFMGTVSRDLKYRTTTAKLRVGLETFSCTANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT +M W A D+ +P F++G ++ ++ V L E T PPDYLTE+ELI+LME++G
Sbjct: 443 LDAGFTKVMTWQAFGRDEPMPPFVQGTQVAINDVRLAESQTGPPDYLTEAELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV+++ GRKL+PTTLGI LV GYQ IDP+L LP +RS +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVRIENGRKLIPTTLGIVLVHGYQKIDPELVLPTMRSEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIA+G D V++H I+ FK KF YFVK I MDALFE FS L +SG+ S+CGKC
Sbjct: 563 LTLIAQGSADFQDVLRHAIKIFKLKFMYFVKNIANMDALFEVSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+F+LL S G G+S+P
Sbjct: 623 RRYMKYIQTKPARLHCSHCDETYSLPS-GNVKVYREFKCPLDDFDLLAFSTGVKGRSYPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + L C C H TCP+SL + G+ C EC
Sbjct: 682 CPYCYNHPPFSDMPNLGG-----------------CNTCTHATCPHSLNTLGISGCVECP 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +++ + +C EC + + V + +
Sbjct: 725 TGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKVTVEEAKCQECGAQQVTVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GC+ C LVE KH
Sbjct: 785 KDGSEEKSGCVFCSSDFSHLVE-KH 808
>F1KW18_ASCSU (tr|F1KW18) DNA topoisomerase OS=Ascaris suum PE=2 SV=1
Length = 858
Score = 598 bits (1542), Expect = e-168, Method: Compositional matrix adjust.
Identities = 302/634 (47%), Positives = 408/634 (64%), Gaps = 31/634 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV R+ I FKPE +W V + G E++ E+ R ++FD
Sbjct: 208 LDSTCISFGPCQTPTLGFCVTRHDLITQFKPEPYWLVQVVLETKDGKELRPEFSRGRIFD 267
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+V +F + V ++ + V+++ K+ K RP LNTV +++VASS LG P AM AE
Sbjct: 268 RDVCQLFLERVKKENIGMVSDVFTKEGRKDRPQALNTVEMMRVASSGLGMSPSNAMSTAE 327
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LYT+GFISYPRTE+ YP +FD G L Q N+P WGN V+ +L+ G KPR G D GD
Sbjct: 328 YLYTRGFISYPRTETNTYPVNFDLIGPLRQQQNDPRWGNIVKQVLSEGITKPRGGEDKGD 387
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR + + L DA +LYQY+ QHFI T+ C Y + G E F +G+
Sbjct: 388 HPPITPMR-SDDGSLSGDALRLYQYVTQHFIATLMRPCTYLVTTAKICFGEEVFTISGKR 446
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ GFT+I+ W AI D +P +G + + + E TT PD+LTESELISLMEK+
Sbjct: 447 LLDAGFTSILTWQAIGEDTELPELRRGDFLSLKDARIVERATTAPDHLTESELISLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHIN IC+RNYV V++GR+LVPT LGI LV GY IDP+L LP +R+ +E
Sbjct: 507 GIGTDASIPVHINTICQRNYVTVESGRRLVPTKLGIALVHGYWKIDPELVLPTMRAEVEA 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIAKGQ + V H + F+ KF YFV+ I ++D+LFE F+TL D+G+ S+CGK
Sbjct: 567 QLNLIAKGQANFFAVKNHALDNFRLKFIYFVENILSVDSLFEDSFTTLADTGKPFSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK- 481
C R+MK I+ +P RL+C C+E Y LP + GT++L+ E CPLD F+L+ G GK
Sbjct: 627 CRRFMKLIATKPQRLHCPSCQETYSLPSGKDGTLRLHAEHKCPLDEFDLVYWQ-GSGGKL 685
Query: 482 --SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVC 539
S+ LCPYCY+NPPFEG+ KG G C C HP CP+S ++QG+
Sbjct: 686 SVSYALCPYCYNNPPFEGMR---------------KGWG--CNQCTHPACPHSFMTQGLV 728
Query: 540 ACP-EC---SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEV 595
CP EC +G LVLDP SAPKWRL CN C +V L +GA ++ +++C C + ++ V
Sbjct: 729 KCPRECAGGTGILVLDPQSAPKWRLACNRCPAVVGLFEGASKVRVHEKQCGHCHAQLVIV 788
Query: 596 DFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
++ K +PL DG + +RGCI CDE + SL+ + H
Sbjct: 789 EYKDK-SPLPDGKSTYRGCIFCDETIASLINLNH 821
>B4I0C6_DROSE (tr|B4I0C6) DNA topoisomerase OS=Drosophila sechellia
GN=Dsec\GM12581 PE=3 SV=1
Length = 921
Score = 598 bits (1541), Expect = e-168, Method: Compositional matrix adjust.
Identities = 293/625 (46%), Positives = 396/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E+ LEW R ++F
Sbjct: 252 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQ--LLAGQPEVTLEWARGRVFKK 309
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V ++ K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 310 DIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 369
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G +L + PR G D GDH
Sbjct: 370 LYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDH 428
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ D W++Y++IC+HF+GTVS D KY + +G E+F CT +
Sbjct: 429 PPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLRVGMETFSCTASVL 488
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
I GFT +M W A D+ P F++G ++ ++ V L E T PPDYLTESELI+LME++G
Sbjct: 489 IDAGFTKVMTWSAFGKDEPQPPFVQGTEVAINDVRLIESQTGPPDYLTESELITLMEEHG 548
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L LP +R+ +E+
Sbjct: 549 IGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERM 608
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIA+G + V++H I+ FK KF YFVK I++MDALFE FS L +SG+ S+CGKC
Sbjct: 609 LTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKC 668
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+F+LL+ S G G+S+P
Sbjct: 669 RRYMKYIQTKPARLHCSHCDETYALPI-GNVKVYREFKCPLDDFDLLVFSTGVKGRSYPF 727
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + L C C + CP+SL + G+ +C EC
Sbjct: 728 CPYCYNHPPFSDMPHLGG-----------------CNTCTNANCPHSLNTLGISSCVECP 770
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + + V + +
Sbjct: 771 TGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKF 830
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 831 KDGSEEKSGCIFCSTDFSHLVE-KH 854
>B4PYQ9_DROYA (tr|B4PYQ9) DNA topoisomerase OS=Drosophila yakuba GN=Dyak\GE16470
PE=3 SV=1
Length = 878
Score = 597 bits (1539), Expect = e-168, Method: Compositional matrix adjust.
Identities = 294/625 (47%), Positives = 393/625 (62%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQ--LLAGQPEFTLEWARGRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V ++ K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 264 DIAIMLLGRVKEHKEATVESVASKEAFKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G +L + PR G D GDH
Sbjct: 324 LYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSGDFGEEARSILGD-MQTPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ D W++Y++IC+HF+GTVS D KY + +G E+F CT +
Sbjct: 383 PPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLRVGLETFSCTANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
I GFT +M W A D+ +P F++G ++ ++ V L E T PPDYLTESELI+LME++G
Sbjct: 443 IDAGFTKVMTWQAFGRDEPMPPFVQGTQVAINDVRLTESQTGPPDYLTESELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L LP +R+ +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVHIENGRKLIPTTLGIVLVHGYQKIDPELVLPTMRTEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIA+G + V++H I+ FK KF YFVK I MD+LFE FS L +SG+ S+CGKC
Sbjct: 563 LTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIANMDSLFEVSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+F+LL S G G+S+P
Sbjct: 623 RRYMKYIQTKPARLHCSHCDETYALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + L C C H TCP+SL + G+ C EC
Sbjct: 682 CPYCYNHPPFSDMPHLGG-----------------CNTCTHATCPHSLNTLGISGCVECP 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + + V + +
Sbjct: 725 TGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 785 KDGSEEKSGCIFCSTDFSHLVE-KH 808
>B4R5E8_DROSI (tr|B4R5E8) DNA topoisomerase OS=Drosophila simulans
GN=Dsim\GD16199 PE=3 SV=1
Length = 821
Score = 597 bits (1538), Expect = e-168, Method: Compositional matrix adjust.
Identities = 293/625 (46%), Positives = 395/625 (63%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E+ LEW R ++F
Sbjct: 152 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQ--LLAGQPEVTLEWARGRVFKK 209
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V ++ K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 210 DIAIMLLNRVKEHKKATVESVASKEAFKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 269
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G +L + PR G D GDH
Sbjct: 270 LYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDH 328
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ D W++Y++IC+HF+GTVS D KY + +G E+F CT +
Sbjct: 329 PPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLRVGMETFSCTASVL 388
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
I GFT +M W A D+ P F++G ++ ++ V L E T PPDYLTESELI+LME++G
Sbjct: 389 IDAGFTKVMTWSAFGKDEPQPPFVQGTEVAINDVRLIESQTGPPDYLTESELITLMEEHG 448
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L LP +R+ +E+
Sbjct: 449 IGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERM 508
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIA+G + V++H I+ FK KF YFVK I+ MDALFE FS L +SG+ S+CGKC
Sbjct: 509 LTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDNMDALFEVSFSPLAESGKAHSRCGKC 568
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+F+LL+ S G G+S+P
Sbjct: 569 RRYMKYIQTKPARLHCSHCDETYALP-IGNVKVYREFKCPLDDFDLLVFSTGVKGRSYPF 627
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + L C C + CP+SL + G+ +C EC
Sbjct: 628 CPYCYNHPPFSDMPHLGG-----------------CNTCTNANCPHSLNTLGISSCVECP 670
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + + V + +
Sbjct: 671 TGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKF 730
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 731 KDGSEEKSGCIFCSADFSHLVE-KH 754
>B3NXQ6_DROER (tr|B3NXQ6) DNA topoisomerase OS=Drosophila erecta GN=Dere\GG17682
PE=3 SV=1
Length = 878
Score = 596 bits (1537), Expect = e-168, Method: Compositional matrix adjust.
Identities = 294/625 (47%), Positives = 392/625 (62%), Gaps = 24/625 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCV+R+ I TFKPE FW + ++ E LEW R ++F
Sbjct: 206 LDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQ--LLAGQPEFTLEWARGRVFKK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
++A M V E V ++ K+ KS+P LNTV L+++ SS LG GP AMQ+AER
Sbjct: 264 DIAIMLLGRVKEHKKATVESVASKEAFKSKPQALNTVELMRICSSGLGIGPFQAMQIAER 323
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE+ YP +FD L + +G +L + PR G D GDH
Sbjct: 324 LYTQGYISYPRTETNQYPTNFDLAAVLHVLKPSGDFGEEARSILGD-MQTPRKGKDAGDH 382
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPM+ D W++Y++IC+HF+GTVS D KY + +G E+F CT +
Sbjct: 383 PPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLRVGLETFSCTANVL 442
Query: 247 ITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
I GFT +M W A D+ +P F++G ++ ++ V L E T PPDYLTESELI+LME++G
Sbjct: 443 IDAGFTKVMTWQAFGKDEPMPPFVQGTEVAINDVRLTESQTGPPDYLTESELITLMEQHG 502
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L LP +R+ +E+
Sbjct: 503 IGTDASIPVHINNICQRNYVHIENGRKLIPTTLGIVLVHGYQKIDPELVLPTMRTEVERM 562
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+TLIA+G + V++H I+ FK KF YFVK I MD+LFE FS L +SG+ S+CGKC
Sbjct: 563 LTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIANMDSLFEVSFSPLAESGKAHSRCGKC 622
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P+RL+C C E Y LP G +K+Y+E CPLD+F+LL S G G+S+P
Sbjct: 623 RRYMKYIQTKPARLHCSHCYETYALP-IGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPF 681
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC- 544
CPYCY++PPF + L C C H TCP+SL + G+ C EC
Sbjct: 682 CPYCYNHPPFSDMPHLGG-----------------CNTCTHSTCPHSLNTLGISGCVECP 724
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
+G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + + V + +
Sbjct: 725 TGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKF 784
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+DGS GCI C LVE KH
Sbjct: 785 KDGSEEKSGCIFCSTDFSHLVE-KH 808
>Q384B1_TRYB2 (tr|Q384B1) DNA topoisomerase III, putative OS=Trypanosoma brucei
brucei (strain 927/4 GUTat10.1) GN=Tb11.01.0910 PE=3
SV=1
Length = 841
Score = 594 bits (1531), Expect = e-167, Method: Compositional matrix adjust.
Identities = 291/622 (46%), Positives = 389/622 (62%), Gaps = 16/622 (2%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQR+ +I FKPE +W + P G I EW R ++FD
Sbjct: 198 LDASVVSYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPTCNRYGSPITFEWARGRVFDE 257
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+A + + V+ + +V ++S +T++RP LNTV L+K+AS LG GPH AMQ+AE
Sbjct: 258 LIARLLHQRVSRSKVAKVVDVSVGADTRARPTALNTVELMKIASKFLGIGPHHAMQIAEN 317
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY G+ISYPRTESTAYP SFD + AL+ Q +P WG YV+ LL Y +P+ G D GDH
Sbjct: 318 LYISGYISYPRTESTAYPVSFDLKAALATQQGHPVWGEYVQELLKGRYTRPKAGKDAGDH 377
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A L +D+W+LY+YI +HFI TVSPDCK +R K+ + GE F TG+ V
Sbjct: 378 PPITPMRAATAGELSSDSWRLYEYITRHFIATVSPDCKLSRTKLVLELSGELFTFTGKVV 437
Query: 247 ITKGFTAIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT I+ LA+ D +P+ I+ G ++ V L G T P YLTE++LI LMEKNG
Sbjct: 438 VDPGFTTILAHLAVKDDKVPTNIEVGSDFPINDVRLQAGQTQAPGYLTEADLIGLMEKNG 497
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASI H+NNI ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+
Sbjct: 498 IGTDASISQHVNNIVERGYCAVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEY 557
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+T IA+GQ V+ V+ F KF YF + IE DAL A FS L SG+ +++CG C
Sbjct: 558 VTCIAEGQARLDEVLSSVLDLFFGKFRYFKENIERFDALMGASFSPLTSSGKPITRCGNC 617
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
+RY+K++ A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+
Sbjct: 618 MRYLKHLEARPQRLYCAYCEVTYALPQGGTIKQYSNYKCPLDNFELVICHV-EGGKSFPI 676
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC--PE 543
CP CY+NPPF +A + G M C C HPTC +SL + V C P
Sbjct: 677 CPNCYNNPPFP--DARVQ----------GGRQLMACDECKHPTCYHSLATNYVADCVDPR 724
Query: 544 CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
C G + P ++ KW++CCN C ++ L A R+ + E CPEC + ++++ F + +P
Sbjct: 725 CDGCMAFVPRTSGKWKICCNHCTMMILLPPTAQRVYVSSEECPECGAMMVDLQFPEGKSP 784
Query: 604 LEDGSTLHRGCILCDELLHSLV 625
L + C+ CD L + V
Sbjct: 785 LPNRKDRIVSCVFCDPALSNNV 806
>D0A8A5_TRYB9 (tr|D0A8A5) DNA topoisomerase III, putative OS=Trypanosoma brucei
gambiense (strain MHOM/CI/86/DAL972) GN=TbgDal_XI10250
PE=3 SV=1
Length = 841
Score = 594 bits (1531), Expect = e-167, Method: Compositional matrix adjust.
Identities = 291/622 (46%), Positives = 389/622 (62%), Gaps = 16/622 (2%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQR+ +I FKPE +W + P G I EW R ++FD
Sbjct: 198 LDASVVSYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPTCNRYGSPITFEWARGRVFDE 257
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+A + + V+ + +V ++S +T++RP LNTV L+K+AS LG GPH AMQ+AE
Sbjct: 258 LIARLLHQRVSRSKVAKVVDVSVGADTRARPTALNTVELMKIASKFLGIGPHHAMQIAEN 317
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY G+ISYPRTESTAYP SFD + AL+ Q +P WG YV+ LL Y +P+ G D GDH
Sbjct: 318 LYISGYISYPRTESTAYPVSFDLKAALATQQGHPVWGEYVQELLKGRYTRPKAGKDAGDH 377
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A L +D+W+LY+YI +HFI TVSPDCK +R K+ + GE F TG+ V
Sbjct: 378 PPITPMRAATAGELSSDSWRLYEYITRHFIATVSPDCKLSRTKLVLELSGELFTFTGKVV 437
Query: 247 ITKGFTAIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT I+ LA+ D +P+ I+ G ++ V L G T P YLTE++LI LMEKNG
Sbjct: 438 VDPGFTTILAHLAVKDDKVPTNIEVGSDFPINDVRLQAGQTQAPGYLTEADLIGLMEKNG 497
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASI H+NNI ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+
Sbjct: 498 IGTDASISQHVNNIVERGYCAVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEY 557
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+T IA+GQ V+ V+ F KF YF + IE DAL A FS L SG+ +++CG C
Sbjct: 558 VTCIAEGQARLDEVLSSVLDLFFGKFRYFKENIERFDALMGASFSPLTSSGKPITRCGNC 617
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
+RY+K++ A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+
Sbjct: 618 MRYLKHLEARPQRLYCAYCEVTYALPQGGTIKQYSNYKCPLDNFELVICHV-EGGKSFPI 676
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC--PE 543
CP CY+NPPF +A + G M C C HPTC +SL + V C P
Sbjct: 677 CPNCYNNPPFP--DARVQ----------GGRQLMACDECKHPTCYHSLATNYVADCVDPR 724
Query: 544 CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
C G + P ++ KW++CCN C ++ L A R+ + E CPEC + ++++ F + +P
Sbjct: 725 CDGCMAFVPRTSGKWKICCNHCTMMILLPPTAQRVYVSSEECPECGAMMVDLQFPEGKSP 784
Query: 604 LEDGSTLHRGCILCDELLHSLV 625
L + C+ CD L + V
Sbjct: 785 LPNRKDRIVSCVFCDPALSNNV 806
>A4URT2_TRYBB (tr|A4URT2) Topoisomerase IIIbeta OS=Trypanosoma brucei brucei PE=3
SV=1
Length = 841
Score = 594 bits (1531), Expect = e-167, Method: Compositional matrix adjust.
Identities = 291/622 (46%), Positives = 389/622 (62%), Gaps = 16/622 (2%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQR+ +I FKPE +W + P G I EW R ++FD
Sbjct: 198 LDASVVSYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPTCNRYGSPITFEWARGRVFDE 257
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+A + + V+ + +V ++S +T++RP LNTV L+K+AS LG GPH AMQ+AE
Sbjct: 258 LIARLLHQRVSRSKVAKVVDVSVGADTRARPTALNTVELMKIASKFLGIGPHHAMQIAEN 317
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY G+ISYPRTESTAYP SFD + AL+ Q +P WG YV+ LL Y +P+ G D GDH
Sbjct: 318 LYISGYISYPRTESTAYPVSFDLKAALATQQGHPVWGEYVQELLKGRYTRPKAGKDAGDH 377
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A L +D+W+LY+YI +HFI TVSPDCK +R K+ + GE F TG+ V
Sbjct: 378 PPITPMRAATAGELSSDSWRLYEYITRHFIATVSPDCKLSRTKLVLELSGELFTFTGKVV 437
Query: 247 ITKGFTAIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT I+ LA+ D +P+ I+ G ++ V L G T P YLTE++LI LMEKNG
Sbjct: 438 VDPGFTTILAHLAVKDDKVPTNIEVGSDFPINDVRLQAGQTQAPGYLTEADLIGLMEKNG 497
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASI H+NNI ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+
Sbjct: 498 IGTDASISQHVNNIVERGYCAVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEY 557
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+T IA+GQ V+ V+ F KF YF + IE DAL A FS L SG+ +++CG C
Sbjct: 558 VTCIAEGQARLDEVLSSVLDLFFGKFRYFKENIERFDALMGASFSPLTSSGKPITRCGNC 617
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
+RY+K++ A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+
Sbjct: 618 MRYLKHLEARPQRLYCAYCEVTYALPQGGTIKQYSNYKCPLDNFELVICHV-EGGKSFPI 676
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC--PE 543
CP CY+NPPF +A + G M C C HPTC +SL + V C P
Sbjct: 677 CPNCYNNPPFP--DARVQ----------GGRQLMACDECKHPTCYHSLATNYVADCVDPR 724
Query: 544 CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
C G + P ++ KW++CCN C ++ L A R+ + E CPEC + ++++ F + +P
Sbjct: 725 CDGCMAFVPRTSGKWKICCNHCTMMILLPPTAQRVYVSSEECPECGAMMVDLQFPEGKSP 784
Query: 604 LEDGSTLHRGCILCDELLHSLV 625
L + C+ CD L + V
Sbjct: 785 LPNRKDRIVSCVFCDPALSNNV 806
>K2NGF1_TRYCR (tr|K2NGF1) DNA topoisomerase III, putative OS=Trypanosoma cruzi
marinkellei GN=MOQ_001351 PE=3 SV=1
Length = 851
Score = 594 bits (1531), Expect = e-167, Method: Compositional matrix adjust.
Identities = 288/616 (46%), Positives = 391/616 (63%), Gaps = 15/616 (2%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL FCVQR+ +I FKPE +W + P G + +W R ++FD +A +
Sbjct: 204 SYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPVSNRFGSLMTFDWVRGRVFDDLMARLL 263
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
+ V+ +V ++S +T++RP LNTV L+KVAS ALG GPH AMQ+AE LY G+
Sbjct: 264 HQKVSHHRSAKVVDVSVGVDTRARPTALNTVELMKVASKALGMGPHHAMQVAENLYIGGY 323
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SF+F AL+AQ +P WGNYV+ LL G+ +P+ G D GDHPPITPM
Sbjct: 324 ISYPRTESTAYPSSFNFMAALAAQERSPIWGNYVQELLARGHTRPKAGKDAGDHPPITPM 383
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A L D+W+LY+YI +HFI ++SPDCK R K+ IGGE F+ TG+ V GFT
Sbjct: 384 RLATPQELSGDSWRLYEYIARHFIASLSPDCKLTRTKLLIEIGGELFNFTGKVVEDPGFT 443
Query: 253 AIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDAS 311
++P A+ D +P+ I+ G +S V L G T PP YLTE++LI LMEKNGIGTDAS
Sbjct: 444 TVLPQFAVKDDKVPTNIQVGSDFPISDVRLQAGQTQPPGYLTEADLIGLMEKNGIGTDAS 503
Query: 312 IPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAK 371
I H+NNI ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+ +T IA+
Sbjct: 504 ISQHVNNIVERGYCAVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEYVTFIAE 563
Query: 372 GQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKY 431
G+ V+ + + F KF +F + IE DAL A FS+L SG+ +++CG C+RY+K+
Sbjct: 564 GRASLDEVLSYSLDLFFGKFRFFKQNIERFDALMGASFSSLSASGKPITRCGNCMRYLKH 623
Query: 432 ISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYS 491
+ A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+CP CY+
Sbjct: 624 LEARPQRLYCAYCEVTYDLPQGGTIKQYSSFKCPLDNFELVICHVD-GGKSFPICPNCYN 682
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE--CSGTLV 549
NPPFE I+ + G M C C HP C +SL + V C + C G +
Sbjct: 683 NPPFEDIQK-----------QRGGRQHMACDECRHPVCYHSLATNYVADCVDERCDGCMA 731
Query: 550 LDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGST 609
P ++ KW++CCN C ++ L A R+ + E C EC + ++++ F + +PL +
Sbjct: 732 FVPRTSGKWKICCNHCTMMILLPPTAQRVYVSPEECSECGAMMMDLQFPEGKSPLPNRKD 791
Query: 610 LHRGCILCDELLHSLV 625
C+ CD L+S V
Sbjct: 792 RIVACVFCDPTLNSNV 807
>K4E7B0_TRYCR (tr|K4E7B0) DNA topoisomerase III, putative OS=Trypanosoma cruzi
GN=TCSYLVIO_002616 PE=3 SV=1
Length = 852
Score = 592 bits (1526), Expect = e-166, Method: Compositional matrix adjust.
Identities = 288/616 (46%), Positives = 390/616 (63%), Gaps = 15/616 (2%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL FCVQR+ +I FKPE +W + P G + +W R ++FD +A +
Sbjct: 204 SYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPVSNRFGSLMTFDWARGRVFDDLMARLL 263
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
+ V+ +VT++S +T++RP LNTV L+KVAS ALG GPH AMQ+AE LY G+
Sbjct: 264 HQKVSHHRAAKVTDVSVGVDTRARPTALNTVELMKVASKALGMGPHHAMQIAENLYIGGY 323
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SF+F AL+AQ +P WGNYV+ LL G+ +P+ G D GDHPPITPM
Sbjct: 324 ISYPRTESTAYPSSFNFMTALTAQERSPIWGNYVQELLARGHTRPKAGKDAGDHPPITPM 383
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A L D+W+LY+YI +HFI ++SPDCK R K+ IGGE F TG+ V GFT
Sbjct: 384 RLATPQELSGDSWRLYEYIARHFIASLSPDCKLTRTKLLIEIGGELFSFTGKVVEDPGFT 443
Query: 253 AIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDAS 311
++P A+ D +P+ I+ G +S V L G T PP YLTE++LI LMEK GIGTDAS
Sbjct: 444 TVLPQFAVKDDKVPTNIQVGSDFPISDVRLQAGQTQPPGYLTEADLIGLMEKYGIGTDAS 503
Query: 312 IPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAK 371
I H+NNI ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+ +T IA+
Sbjct: 504 ISQHVNNIVERGYCAVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEYVTCIAE 563
Query: 372 GQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKY 431
G+ V+ + + F KF +F + IE DAL A FS+L SG+ +++CG C+RY+K+
Sbjct: 564 GRASLDEVLSYSLDLFFGKFRFFKQNIERFDALMGASFSSLSASGKPITRCGNCMRYLKH 623
Query: 432 ISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYS 491
+ A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+CP CY+
Sbjct: 624 LEARPQRLYCAYCEVTYELPQGGTIKQYSSFKCPLDNFELVICHVD-GGKSFPICPNCYN 682
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE--CSGTLV 549
NPPFE I+ + G M C C HP C +SL + V C + C G +
Sbjct: 683 NPPFEDIQK-----------QRGGRQHMACDECRHPVCYHSLATNYVADCVDERCDGCMA 731
Query: 550 LDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGST 609
P ++ KW++CCN C ++ L A R+ + E C EC + ++++ F + +PL +
Sbjct: 732 FVPRTSGKWKICCNHCTMMILLPPTAQRVYVSPEECSECGAMMMDLQFPEGKSPLPNRKD 791
Query: 610 LHRGCILCDELLHSLV 625
C+ CD L+S V
Sbjct: 792 RIVACVFCDPTLNSNV 807
>F6SDD7_MOUSE (tr|F6SDD7) DNA topoisomerase (Fragment) OS=Mus musculus GN=Top3b
PE=3 SV=1
Length = 527
Score = 591 bits (1524), Expect = e-166, Method: Compositional matrix adjust.
Identities = 279/496 (56%), Positives = 361/496 (72%), Gaps = 4/496 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + VH+ E + L+W R ++F
Sbjct: 2 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAK-VHTDKEESLLLDWDRVRVF 60
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + + V S K++ K RP+ LNTV +L+VASSALG GP AMQ+A
Sbjct: 61 DWEIAQMFLNMTKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIA 120
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D G
Sbjct: 121 ERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAG 180
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C G+
Sbjct: 181 DHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGK 240
Query: 245 HVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
VI+ GFT IMPW ++ ++++P+ KG V +V++ E T+PPDYLTE+ELI+LMEK
Sbjct: 241 TVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEK 300
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
+GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E
Sbjct: 301 HGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVE 360
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+Q+ LIA+G+ D+H+V+ H + FK+KF YFV I MD L E FS L +G+ LS+CG
Sbjct: 361 KQLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCG 420
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSF 483
KC R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+
Sbjct: 421 KCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSY 480
Query: 484 PLCPYCYSNPPFEGIE 499
PLCPYCY++PPF ++
Sbjct: 481 PLCPYCYNHPPFRDMK 496
>Q4DXC5_TRYCC (tr|Q4DXC5) DNA topoisomerase III, putative OS=Trypanosoma cruzi
(strain CL Brener) GN=Tc00.1047053510901.100 PE=3 SV=1
Length = 852
Score = 590 bits (1521), Expect = e-166, Method: Compositional matrix adjust.
Identities = 286/616 (46%), Positives = 391/616 (63%), Gaps = 15/616 (2%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL FCVQR+ +I FKPE +W + P G + +W R ++FD +A +
Sbjct: 204 SYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPVSNRFGSLMTFDWARGRVFDDLMARLL 263
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
+ V+ +VT++S +T++RP LNTV L+KVAS ALG GPH AMQ+AE LY G+
Sbjct: 264 HQKVSHHRAAKVTDVSVGVDTRARPTALNTVELMKVASKALGMGPHHAMQIAENLYIGGY 323
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTESTAYP SF+F AL+AQ +P WGNYV+ LL +G+ +P+ G D GDHPPITPM
Sbjct: 324 ISYPRTESTAYPSSFNFMAALTAQERSPIWGNYVQELLAHGHTRPKAGKDAGDHPPITPM 383
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R A L D+W+LY+YI +HFI ++SPDCK R K+ IGGE F TG+ V GFT
Sbjct: 384 RLATPQELSGDSWRLYEYIARHFIASLSPDCKLTRTKLLIEIGGELFSFTGKVVEDPGFT 443
Query: 253 AIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDAS 311
++P A+ D +P+ I+ G +S V L G T PP YLTE++LI LMEK+GIGTDAS
Sbjct: 444 TVLPQFAVKDDKVPTNIQVGSDFPISDVRLQAGQTQPPGYLTEADLIGLMEKHGIGTDAS 503
Query: 312 IPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAK 371
I H+NNI ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+ +T IA+
Sbjct: 504 ISQHVNNIVERGYCAVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEYVTCIAE 563
Query: 372 GQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKY 431
G+ V+ + + F KF +F + IE DAL A FS+L G+ +++CG C+RY+K+
Sbjct: 564 GRASLDEVLSYSLDLFFGKFRFFKQNIERFDALMGASFSSLSALGKPITRCGNCMRYLKH 623
Query: 432 ISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYS 491
+ A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+CP CY+
Sbjct: 624 LEARPQRLYCAYCEVTYELPQGGTIKQYSSFKCPLDNFELVICHVD-GGKSFPICPNCYN 682
Query: 492 NPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE--CSGTLV 549
NPPFE I+ + G M C C HP C +SL + V C + C G +
Sbjct: 683 NPPFEDIQK-----------QRGGRQHMACDECRHPVCYHSLATNYVADCVDERCDGCMA 731
Query: 550 LDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGST 609
P ++ KW++CCN C ++ L A R+ + E C EC + ++++ F + +PL +
Sbjct: 732 FVPRTSGKWKICCNHCTMMILLPPTAQRVYVSPEECSECGAMMMDLQFPEGKSPLPNRKD 791
Query: 610 LHRGCILCDELLHSLV 625
C+ C+ L+S V
Sbjct: 792 RIVACVFCEPTLNSNV 807
>C5KCJ6_PERM5 (tr|C5KCJ6) DNA topoisomerase OS=Perkinsus marinus (strain ATCC
50983 / TXsc) GN=Pmar_PMAR023511 PE=3 SV=1
Length = 850
Score = 589 bits (1519), Expect = e-165, Method: Compositional matrix adjust.
Identities = 293/631 (46%), Positives = 405/631 (64%), Gaps = 34/631 (5%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--GYEIQLEWQRSKLF 64
L + SYGPCQTPTL FCV+R+ I TF+PE +++++ + S + LEW R +LF
Sbjct: 203 LDSSLVSYGPCQTPTLWFCVRRHNDIQTFQPETYYTIDVKLEGSQLASPLWLEWSRGQLF 262
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D+ AT F+ ++ VT++SEK+E +SRP +NTV +LK+AS LG GP AMQ+A
Sbjct: 263 DLQAATTFKSMIDAYQWATVTDVSEKEERRSRPGAMNTVLMLKLASQQLGMGPQQAMQVA 322
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLY G+I+YPRTE+T YPP+FD R A+S Q+ NP WG + LLT G +P+ G D G
Sbjct: 323 ERLYLSGYITYPRTETTKYPPAFDLREAVSFQSRNPYWGEFATELLTTGLNRPKEGYDAG 382
Query: 185 DHPPITPMRPAAE-DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTG 243
DHPPITP+R A E D +D+W+L+ + +HF+ ++ DCK+ R KV F IG E +
Sbjct: 383 DHPPITPVRSATEGDFGSSDSWRLFDMLTRHFLASLGHDCKFTRTKVHFVIGEEVSTSSN 442
Query: 244 QHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
H A W + +P G+K++++ + T PP YL+ES+L+ LMEK
Sbjct: 443 SH------RAGHYWRLVTRMVLPQLKIGEKLQIASKSISSAKTKPPPYLSESDLLGLMEK 496
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
NGIGTDAS+ HINNICERNYV + GR+LVPT LGITLV GYQ+ID +L +P +R+ IE
Sbjct: 497 NGIGTDASMATHINNICERNYVSLTDGRRLVPTKLGITLVHGYQAIDNELVIPRVRANIE 556
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
+ TLIA G+ V H + F+QKF YFV ++ MD LFE+ F++L +G+++S+CG
Sbjct: 557 SECTLIANGKARKDEVTAHALTIFQQKFMYFVSHVDLMDHLFESTFTSLAATGKLMSRCG 616
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKG-TIKLYKELSCPLDNFELLLCS----MGP 478
KC YM I +P RL+C C+E Y LPQ G ++KLYKEL+CPLDNF+L++ S G
Sbjct: 617 KCRTYMNLIDKKPVRLFCRHCDETYALPQTGSSVKLYKELTCPLDNFQLVMISYPSTAGG 676
Query: 479 DGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGV 538
K +PLCP CY++PPF +K +S C C HPTC ++L S GV
Sbjct: 677 GRKQYPLCPMCYNDPPFP-------ESKPKSS----------CWECLHPTCKHALASVGV 719
Query: 539 CACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQG-AHRISTTKERCPECDSSIIEV 595
C CP+ CSGTL LD S PKW+L CN CN + L Q AH+I+ TK++C C S ++ V
Sbjct: 720 CGCPQDSCSGTLCLDAESKPKWKLDCNTCNYQLRLFQDKAHKITVTKDKCENCGSKLLNV 779
Query: 596 DFNKKATPLEDGSTLHRGCILCDELLHSLVE 626
+F+K + L +G+ GC++CD+ L+S VE
Sbjct: 780 EFSKGKSSLSNGAESVVGCLVCDDALNSQVE 810
>F0WSH2_9STRA (tr|F0WSH2) DNA topoisomerase OS=Albugo laibachii Nc14
GN=AlNc14C232G9314 PE=3 SV=1
Length = 928
Score = 588 bits (1516), Expect = e-165, Method: Compositional matrix adjust.
Identities = 310/695 (44%), Positives = 401/695 (57%), Gaps = 96/695 (13%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCV R+ QI F+PE FW++ I I+L+W R +FD
Sbjct: 211 SYGPCQTPTLGFCVDRFDQIQQFQPEPFWTIEVGITKDNQTIKLDWDRGHIFDHEAVCAL 270
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
+++++ +L V+ + E + T+ RP LNTV LL+ AS L GP MQ+AERLY QG+
Sbjct: 271 NEVISDKNILLVSSVKESEVTRFRPTPLNTVQLLQHASKQLSMGPFTTMQIAERLYLQGY 330
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTEST+YP SFD L N WG YVE LL GY +P+ G DVGDHPPITP+
Sbjct: 331 ISYPRTESTSYPDSFDVESTLLQHTRNSHWGTYVENLLHRGYQRPKKGVDVGDHPPITPV 390
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R L + +LY +I ++FI TVS D + V F+ E F TG V+ KGFT
Sbjct: 391 RAVELKDLAGEMARLYDFIARYFIATVSRDARLLATSVSFTCQTEKFSLTGHRVLDKGFT 450
Query: 253 AIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASI 312
I+ ++ D +P F G+ + +++ + +G T+PP +LTESELI LMEK+GIGTDASI
Sbjct: 451 EILTSTSLVDTIVPDFKVGEVLPIARQNVRQGQTSPPGFLTESELIGLMEKHGIGTDASI 510
Query: 313 PVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKG 372
P HINNICERNYV++ +GR LVPT LG+ LV GY +DP+L LP +R+ IE+Q TLIAKG
Sbjct: 511 PAHINNICERNYVRLGSGRTLVPTNLGVVLVHGYYKVDPELVLPRVRAAIEEQCTLIAKG 570
Query: 373 QIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYI 432
VV+H +Q F+ KF YFV+KI MDALFEA FS L +G+ LSKCGKC RYM+Y+
Sbjct: 571 IASKEEVVEHSLQIFRAKFAYFVRKISMMDALFEATFSPLAATGKPLSKCGKCSRYMRYV 630
Query: 433 SAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPD----GKSFPLCPY 488
+P RL+C C E Y LPQ G+IKLYKE CP D FEL+L S+G GKS+PLCPY
Sbjct: 631 HLKPQRLHCPTCNETYSLPQNGSIKLYKEYRCPFDQFELVLFSLGNSEKAMGKSYPLCPY 690
Query: 489 CYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP------ 542
CY++PPFE T K+G C C HP+C +SL+ GVC CP
Sbjct: 691 CYNHPPFE-----------DTLDKMG------CNACLHPSCKHSLMQNGVCPCPGSNPEE 733
Query: 543 -------------------------------------ECSGTLVLDPVSAPKWRLCCNMC 565
C+G+LVLD S P W+L CN+C
Sbjct: 734 IHRATFRKTRIKSEGKPNRKDKEESKIKSDATEHVNTPCNGSLVLDVNSKPNWKLACNIC 793
Query: 566 NCLV-FLAQGA-HRISTTK------------------ERCPECDSSIIEVDFN------- 598
N L+ F + A H I T K ++C CDS+ + V+F+
Sbjct: 794 NLLIRFRSDVAIHNIRTVKASMGAKTECGEQDSPNCAQKCSSCDSNNLVVEFHKDKVAAI 853
Query: 599 -KKATPLEDGS----TLHRGCILCDELLHSLVEMK 628
K+AT S T + GC+LCD L + E K
Sbjct: 854 KKEATASNAQSWSADTTYVGCLLCDPFLSQVTERK 888
>F6QNQ6_MACMU (tr|F6QNQ6) DNA topoisomerase OS=Macaca mulatta GN=TOP3B PE=2 SV=1
Length = 707
Score = 585 bits (1508), Expect = e-164, Method: Compositional matrix adjust.
Identities = 272/495 (54%), Positives = 358/495 (72%), Gaps = 2/495 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 267 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 387 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 447 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 567 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 686
Query: 485 LCPYCYSNPPFEGIE 499
LCPYCY++PPF ++
Sbjct: 687 LCPYCYNHPPFRDMK 701
>E9BJR1_LEIDB (tr|E9BJR1) DNA topoisomerase III, putative OS=Leishmania donovani
(strain BPK282A1) GN=LDBPK_281900 PE=3 SV=1
Length = 867
Score = 585 bits (1508), Expect = e-164, Method: Compositional matrix adjust.
Identities = 287/629 (45%), Positives = 392/629 (62%), Gaps = 10/629 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I FKPE FW + P G +Q EW R +LFD
Sbjct: 198 LDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDE 257
Query: 67 NVATM-FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A + Q++ + V +S +T+ RP GLNTV+L+K+AS ALG GPH M +AE
Sbjct: 258 TMARLILQRITKSGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAE 317
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LY +G+ISYPRTESTAYPPSF+ GAL+ Q N+ WG YV LL G+ +P+ G D GD
Sbjct: 318 NLYIRGYISYPRTESTAYPPSFNLAGALAQQKNHSMWGAYVTALLQQGHARPKAGKDAGD 377
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+ L D W++++YI +HFI +VSPDC+ + K+ +GGE F +G+
Sbjct: 378 HPPITPMRSASPSELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKV 437
Query: 246 VITKGFTAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT IMP + D +P+ + KG ++S V L G T PP YLTES+LI LMEKN
Sbjct: 438 VEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKN 497
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI H+NNI ER Y VQAGR + P+ LGI L+ G ++IDP+L LP +RS +E+
Sbjct: 498 GIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEE 557
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+T IA+G+ V+ + + F KF +F + I+ DAL A FS + +G+ +++CG
Sbjct: 558 YVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGN 617
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C+RY+K++ +P RLYC CE + LPQ GTIK Y CP+DNFEL++C + GKSFP
Sbjct: 618 CMRYLKHLDTRPQRLYCPYCEVTFALPQGGTIKPYSSFKCPIDNFELVICHI-EGGKSFP 676
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAG-----MPCILCPHPTCPNSLVSQGVC 539
+CP+CY+NPPFE + I G M C C HPTC +SL + VC
Sbjct: 677 ICPHCYNNPPFEDMRPAIQHHHRGYGGGAAATTAPSTRHMACDECRHPTCEHSLATNYVC 736
Query: 540 ACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF 597
C + C+G++ P +A +W++CCN C ++ L A R+ T E CPEC ++ +++ F
Sbjct: 737 DCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTSEECPECAANCLDIMF 796
Query: 598 NKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ + L + CI C L L E
Sbjct: 797 PEGKSVLPNRKDRIVACIFCHPGLSPLCE 825
>H0Y6W0_HUMAN (tr|H0Y6W0) DNA topoisomerase (Fragment) OS=Homo sapiens GN=TOP3B
PE=3 SV=1
Length = 525
Score = 584 bits (1506), Expect = e-164, Method: Compositional matrix adjust.
Identities = 271/495 (54%), Positives = 357/495 (72%), Gaps = 2/495 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 2 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 61
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 62 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 121
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 122 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 181
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+LY+YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 182 HPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 241
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT +MPW ++ ++++P+ +G V +V++ E T PPDYLTE+ELI+LMEK+
Sbjct: 242 VLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKH 301
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 302 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 361
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 362 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 421
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C R+MKYI A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+P
Sbjct: 422 CHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYP 481
Query: 485 LCPYCYSNPPFEGIE 499
LCPYCY++PPF ++
Sbjct: 482 LCPYCYNHPPFRDMK 496
>A4I3Q5_LEIIN (tr|A4I3Q5) Putative DNA topoisomerase III OS=Leishmania infantum
GN=LINJ_28_1900 PE=3 SV=1
Length = 867
Score = 584 bits (1505), Expect = e-164, Method: Compositional matrix adjust.
Identities = 288/629 (45%), Positives = 392/629 (62%), Gaps = 10/629 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I FKPE FW + P G +Q EW R +LFD
Sbjct: 198 LDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDE 257
Query: 67 NVATM-FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A + Q++ + V +S +T+ RP GLNTV+L+K+AS ALG GPH M +AE
Sbjct: 258 TMARLILQRITKSGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAE 317
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LY +G+ISYPRTESTAYPPSF+ GAL+ Q N+ WG YV LL G+ +P+ G D GD
Sbjct: 318 NLYIRGYISYPRTESTAYPPSFNLAGALAQQKNHSMWGAYVTALLQQGHARPKAGKDAGD 377
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+ L D W++++YI +HFI +VSPDC+ + K+ +GGE F +G+
Sbjct: 378 HPPITPMRSASPSELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKV 437
Query: 246 VITKGFTAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT IMP + D +P+ + KG ++S V L G T PP YLTES+LI LMEKN
Sbjct: 438 VEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKN 497
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI H+NNI ER Y VQAGR + P+ LGI L+ G ++IDP+L LP +RS +E+
Sbjct: 498 GIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEE 557
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+T IA+G+ V+ + + F KF +F + I+ DAL A FS + +G+ +++CG
Sbjct: 558 YVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGN 617
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C+RY+K++ +P RLYC CE + LPQ GTIK Y CP+DNFEL++C + GKSFP
Sbjct: 618 CMRYLKHLDTRPQRLYCPYCEVTFALPQGGTIKPYSSFKCPIDNFELVICHI-EGGKSFP 676
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAG-----MPCILCPHPTCPNSLVSQGVC 539
+CP+CY+NPPFE + I G M C C HPTC +SL + VC
Sbjct: 677 ICPHCYNNPPFEDMRPAIQHHHRGYGGGAAATTAPSTRHMACDECRHPTCEHSLATNYVC 736
Query: 540 ACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF 597
C + C+G++ P +A +W++CCN C ++ L A R+ T E CPEC S+ +++ F
Sbjct: 737 DCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTFEECPECASNCLDIMF 796
Query: 598 NKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ + L + CI C L L E
Sbjct: 797 PEGKSVLPNRKDRIVACIFCHPGLSPLCE 825
>A4HGN1_LEIBR (tr|A4HGN1) Putative DNA topoisomerase III OS=Leishmania
braziliensis GN=LBRM_28_1950 PE=3 SV=2
Length = 866
Score = 584 bits (1505), Expect = e-164, Method: Compositional matrix adjust.
Identities = 290/629 (46%), Positives = 401/629 (63%), Gaps = 10/629 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I FKPE FW + P SG +Q +W R ++FD
Sbjct: 198 LDASVVSYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRSGAVLQFDWDRGRVFDE 257
Query: 67 NVATMFQKLVAEDG-LLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A + + + ++G + VT +S +T+ RP GLNTV+L+K+AS ALG GPH M +AE
Sbjct: 258 TMARLILQRITKNGKVATVTNMSVSSDTRPRPTGLNTVDLMKIASKALGIGPHYVMTIAE 317
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LY +G+ISYPRTESTAYPPSF+ GAL+ Q N+P WG YV LL G++ P+ G D GD
Sbjct: 318 NLYIRGYISYPRTESTAYPPSFNLVGALAQQKNHPIWGGYVTALLQGGHVHPKAGKDAGD 377
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+ L D W++++YI +HFI +VSPDC+ + K+ +GGE F +G+
Sbjct: 378 HPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKV 437
Query: 246 VITKGFTAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT IMP + D +P+ + KG ++S V L G T PP YLTES+LI LMEKN
Sbjct: 438 VEDPGFTEIMPHARVEDDRMPTGVNKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKN 497
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI HINNI ER Y VQAGR + P+ LGI L+ G ++IDP+L LP +RS +E+
Sbjct: 498 GIGTDASISTHINNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEE 557
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+T IA+G+ V+ + + F KF +F + I+ D L A FS + +G+ +++CG
Sbjct: 558 YVTHIAEGRARLEDVLSYSLDLFFSKFKFFKEHIDIFDGLMGASFSAISATGKPITRCGN 617
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C+RY+K+++ +P RLYC CE + LPQ GT+K Y +CP+DNFEL++C + GKSFP
Sbjct: 618 CMRYLKHLNTRPQRLYCPYCEVTFALPQGGTVKPYSGFTCPIDNFELVVCHID-GGKSFP 676
Query: 485 LCPYCYSNPPFEGI-EALINTAKTSTSGKIGKGA----GMPCILCPHPTCPNSLVSQGVC 539
+CP CY+NPPFE + AL + + + G K A M C C HPTC +SL + VC
Sbjct: 677 ICPSCYNNPPFEELPSALQHHNRGNGGGATAKAAPSTRHMACDECRHPTCEHSLATNYVC 736
Query: 540 ACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF 597
C + C G++ P +A +W++CCN C +V L A R+ T E C EC ++ +++ F
Sbjct: 737 DCVDGSCPGSMAFVPRTAGQWKVCCNACPMMVKLPPTAQRVYVTAEECAECAANCLDIMF 796
Query: 598 NKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ + L + CI C L L E
Sbjct: 797 PEGKSVLPNRKDRIVACIFCHPGLSPLCE 825
>G0V1G7_TRYCI (tr|G0V1G7) Putative uncharacterized protein TCIL3000_11_9530
OS=Trypanosoma congolense (strain IL3000)
GN=TCIL3000_11_9530 PE=3 SV=1
Length = 838
Score = 583 bits (1504), Expect = e-164, Method: Compositional matrix adjust.
Identities = 290/622 (46%), Positives = 392/622 (63%), Gaps = 16/622 (2%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQR+ +I FKPE +W + P G + EW R ++FD
Sbjct: 198 LDANVVSYGPCQTPTLAFCVQRHDEILNFKPENYWKLVPTTNRFGAPVTFEWVRGRVFDE 257
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+A + + ++ +V ++S +T++RPV LNTV L+KVAS LG GPH AMQLAE
Sbjct: 258 LIARLIHQRLSRLRTAKVIDVSVAPDTRARPVALNTVELMKVASKLLGIGPHHAMQLAEN 317
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY G+ISYPRTESTAYP SFD RGAL+ Q +P WG++V+GLL + +P+ G D GDH
Sbjct: 318 LYIAGYISYPRTESTAYPASFDLRGALATQERHPLWGDHVQGLLKGRHTRPKAGKDAGDH 377
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A + +++WKLY+YI +HFI TVS DCK AR +V +GGE F TG+ V
Sbjct: 378 PPITPMRAATASDMSSESWKLYEYITRHFIATVSSDCKLARTRVVLDLGGEIFTYTGKVV 437
Query: 247 ITKGFTAIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
GFTA++ LA+ D +P+ I+ G +S V L G T PP YLTE++LI LMEKNG
Sbjct: 438 EDPGFTAVLTHLAVKDDKVPTNIEVGSDFPISDVRLQAGQTQPPGYLTEADLIGLMEKNG 497
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASI H+NN+ ER Y V+ GR + PT LG+ L+ G +SIDP+L LP +RS +E+
Sbjct: 498 IGTDASISQHVNNVVERGYCVVKPGRVMEPTKLGVVLIHGIKSIDPELVLPLVRSKVEEY 557
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+T IA+GQ V+ V+ F KF +F + IE +D+L A FS+L SG+ +++CG C
Sbjct: 558 VTCIAEGQATREEVLSSVLDLFFGKFRFFKENIERLDSLMAASFSSLSASGKPITRCGNC 617
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
+RY+K+I A+P RLYC CE Y LPQ GTIK Y CPLDNFEL++C + GKSFP+
Sbjct: 618 MRYLKHIEARPQRLYCAYCEVTYALPQGGTIKQYSSYKCPLDNFELVICHV-EGGKSFPI 676
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE-- 543
CP CY+NPPFE + G M C C HPTC +SL + V C +
Sbjct: 677 CPNCYNNPPFEDTQMR------------GGRKLMACDECRHPTCSHSLATNYVADCVDQR 724
Query: 544 CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
C G + P S+ KW++CCN C ++ L A R+ + E C C + ++++ F + +P
Sbjct: 725 CDGCMAFVPRSSGKWKICCNHCTMMILLPPTAQRVYVSSEECSVCSAMMMDMQFPEGKSP 784
Query: 604 LEDGSTLHRGCILCDELLHSLV 625
+ C+ CD +L + V
Sbjct: 785 FPNRKERIVACVFCDPVLSANV 806
>D0EG00_LEIDO (tr|D0EG00) DNA topoisomerase III beta OS=Leishmania donovani PE=3
SV=1
Length = 866
Score = 579 bits (1492), Expect = e-162, Method: Compositional matrix adjust.
Identities = 284/629 (45%), Positives = 391/629 (62%), Gaps = 10/629 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I FKPE FW + P G +Q EW R +LFD
Sbjct: 198 LDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDE 257
Query: 67 NVATMFQKLVAEDG-LLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A + + + ++G + V +S +T+ RP GLNTV+L+K+AS ALG GPH M +AE
Sbjct: 258 TMARLILQRITKNGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAE 317
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LY +G+ISYPRTESTAYPPSF+ G L+ Q N+ WG YV LL G+ +P+ G D GD
Sbjct: 318 NLYIRGYISYPRTESTAYPPSFNLAGTLAQQKNHSMWGAYVTALLQQGHARPKAGKDAGD 377
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+ L D W++++YI +HFI +VSPDC+ + K+ +GGE F +G+
Sbjct: 378 HPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFGISGKV 437
Query: 246 VITKGFTAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT IMP + D +P+ + KG ++S V L G T PP YLTES+LI LMEKN
Sbjct: 438 VEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKN 497
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI H+NNI ER Y VQAGR + P+ LGI L+ G ++IDP+L LP +RS +E+
Sbjct: 498 GIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEE 557
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+T IA+G+ V+ + + F KF +F + I+ DAL A FS + +G+ +++CG
Sbjct: 558 YVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGN 617
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C+RY+K++ +P RLYC CE + LPQ G IK Y CP+DNFEL++C + GKSFP
Sbjct: 618 CMRYLKHLDTRPQRLYCPYCEVTFALPQGGAIKPYSSFKCPIDNFELVICHI-EGGKSFP 676
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAG-----MPCILCPHPTCPNSLVSQGVC 539
+CP+CY+NPPFE + I G M C C HPTC +SL + VC
Sbjct: 677 ICPHCYNNPPFEDMRPAIQHHHRGYGGGAAATMAPSTRHMACDECRHPTCEHSLATNYVC 736
Query: 540 ACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF 597
C + C+G++ P + +W++CCN C ++ L A R+ T E CPEC ++ +++ F
Sbjct: 737 DCVDGSCAGSMAFVPRTTGQWKVCCNKCPMMIKLPPTAQRVYVTSEECPECAANCLDIMF 796
Query: 598 NKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ + L + CI C L L E
Sbjct: 797 PEGKSVLPNRKDRIVACIFCHPGLSPLCE 825
>G4VFA7_SCHMA (tr|G4VFA7) Putative prokaryotic DNA topoisomerase OS=Schistosoma
mansoni GN=Smp_169790 PE=3 SV=1
Length = 1159
Score = 578 bits (1491), Expect = e-162, Method: Compositional matrix adjust.
Identities = 302/630 (47%), Positives = 392/630 (62%), Gaps = 48/630 (7%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
S+GPCQTPTLGFCV+R+ QI +FKPE FW + + ++W I+V T F
Sbjct: 522 SFGPCQTPTLGFCVKRHDQIQSFKPETFWRIKECL------FAIKW-------ISVGTFF 568
Query: 73 --QKLVAEDGL-----LEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+KL L L V ++S KQ+ K RP GLNTV +L+VAS+ LG GPH AM +AE
Sbjct: 569 SCRKLFISQFLMGRIVLTVVQVSVKQKIKPRPQGLNTVEMLRVASAGLGIGPHSAMAIAE 628
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYT G+I+YPRTE+TAYP +FD RG L Q NNP WG+ +L +G PR G D GD
Sbjct: 629 RLYTSGYINYPRTETTAYPNTFDLRGLLQQQVNNPLWGDLAREILHSGLTPPRAGHDAGD 688
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIG-GESFHCTGQ 244
HPPI PMR A+ LG++A++LY+YI QHFI T+ PDC Y + +V S+G GE F +G
Sbjct: 689 HPPIAPMRFASSQELGHEAYRLYEYITQHFIATIMPDCCYEQTQVIVSVGDGELFTISGL 748
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVE---LYEGTTTPPDYLTESELISLM 301
V+ GFT I+ W A+ DK++P + Q + + +E L EG T PPDYLTESELI+ M
Sbjct: 749 KVVEPGFTRILTWQAVEDKSLPKSLLNQGYQFNLLEEPSLIEGQTGPPDYLTESELITAM 808
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
E++GIGTDASIP HI NI +R YVQ+ +GRKL PT LGI LV GYQ+ID +L LP +R
Sbjct: 809 ERHGIGTDASIPTHIENIVQRGYVQLLSGRKLQPTPLGIVLVHGYQTIDAELVLPHMRRA 868
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ IA+G + V+Q V+ F K+ YFV+ I MD LFE F+TL SG+ LS+
Sbjct: 869 VEEQLNHIARGHAKYDLVLQFVLAIFAAKYRYFVEHINGMDQLFEVSFTTLASSGKPLSR 928
Query: 422 CGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGK 481
CGKC RY+K+I ++P RL+C IC E Y LPQ GTI+ YK CPLD FELL + G G+
Sbjct: 929 CGKCHRYLKFIDSRPQRLHCSICNETYTLPQNGTIRPYKTEKCPLDKFELLCYTQGGKGR 988
Query: 482 SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC 541
+ CPYC+S+PPFE + L SG C CPHPTCP S+ S GV AC
Sbjct: 989 NMVFCPYCFSHPPFESMPKL--------SG---------CNRCPHPTCPQSMESLGVDAC 1031
Query: 542 PECS-GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKK 600
P+C G LVLD +APK+RL CN C + ++ +S C C + + + F+
Sbjct: 1032 PDCPYGILVLDDSNAPKYRLNCNRCPTFLSISDSVKSMSVKNVSCSVCTAMHLNLRFDPG 1091
Query: 601 ATP------LEDGSTLHRGCILCDELLHSL 624
P E +T GC C E L SL
Sbjct: 1092 KVPNSSENNSEKINTTFSGCAFCTESLCSL 1121
>E9AZZ7_LEIMU (tr|E9AZZ7) Putative DNA topoisomerase III OS=Leishmania mexicana
(strain MHOM/GT/2001/U1103) GN=LMXM_28_1780 PE=3 SV=1
Length = 866
Score = 578 bits (1489), Expect = e-162, Method: Compositional matrix adjust.
Identities = 285/629 (45%), Positives = 390/629 (62%), Gaps = 10/629 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I FKPE FW + P G +Q EW R +LFD
Sbjct: 198 LDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVATRGGALLQFEWDRGRLFDE 257
Query: 67 NVATMFQKLVAEDG-LLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A + + + ++G + V +S +T+ RP GLNTV+L+K+AS ALG GPH M +AE
Sbjct: 258 TMARLILQRITKNGKVATVANVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAE 317
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LY +G+ISYPRTESTAYPPSF+ G L+ Q N+ WG YV LL G+ +P+ G D GD
Sbjct: 318 NLYIRGYISYPRTESTAYPPSFNLAGTLAQQKNHSMWGAYVTALLQQGHARPKAGKDAGD 377
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+ L D W++++YI +HFI +VSPDC+ + K+ +GGE F +G+
Sbjct: 378 HPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGEFFSISGKV 437
Query: 246 VITKGFTAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT IMP + D +P+ I KG ++S V L G T PP YLTES+LI LMEKN
Sbjct: 438 VEDPGFTEIMPHARVEDDRMPTGINKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKN 497
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI H+NNI ER Y VQAGR + P+ LGI L+ G ++IDP+L LP +RS +E+
Sbjct: 498 GIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEE 557
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+T IA+G+ V+ + + F KF +F + I+ DAL A FS + +G+ +++CG
Sbjct: 558 YVTHIAEGRAQLDDVLSYSLDLFFSKFKFFKEHIDVFDALMGASFSAISATGKPITRCGN 617
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C+RY+K++ +P RLYC CE + LPQ G IK Y CP+DNFEL++C + GKSFP
Sbjct: 618 CMRYLKHLDTRPQRLYCPYCEVTFALPQGGAIKQYSSFKCPIDNFELVICHI-EGGKSFP 676
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAG-----MPCILCPHPTCPNSLVSQGVC 539
+CP CY+NPPFE + I G M C C HPTC +SL + VC
Sbjct: 677 ICPQCYNNPPFEDMRPAIQHHHRGYGGGAAATTAPSTRHMACDECRHPTCEHSLATNYVC 736
Query: 540 ACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF 597
C + C+G++ P +A +W++CCN C ++ L A R+ T E C EC ++ +++ F
Sbjct: 737 DCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTSEECLECAANCLDIMF 796
Query: 598 NKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ + L + CI C L L E
Sbjct: 797 PEGKSVLPNRKDRIVACIFCHPGLSPLCE 825
>I1BYY5_RHIO9 (tr|I1BYY5) DNA topoisomerase OS=Rhizopus delemar (strain RA 99-880
/ ATCC MYA-4621 / FGSC 9543 / NRRL 43880) GN=RO3G_06120
PE=3 SV=1
Length = 761
Score = 576 bits (1484), Expect = e-161, Method: Compositional matrix adjust.
Identities = 286/632 (45%), Positives = 380/632 (60%), Gaps = 75/632 (11%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTL FCV+R+ +I F+PE FWS+ + +S L W R ++FD
Sbjct: 189 LDSTVISYGPCQTPTLSFCVERHDRIQGFQPESFWSIKVTVKNSDTSTNLTWNRERVFDR 248
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
V +F K+ E K ++LG P AM +AER
Sbjct: 249 QVGHLFFKMTEE---------------------------AKGNGASLGISPSEAMSIAER 281
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYTQG+ISYPRTE++ YP +FD L QAN+P WG+Y + LL NGY +P G DVGDH
Sbjct: 282 LYTQGYISYPRTETSKYPETFDINSVLVQQANHPHWGHYCDDLLKNGYDRPSGGVDVGDH 341
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITP R A E L D W++Y ++ ++FIG++S KY V F IG E F C G V
Sbjct: 342 PPITPTRVALESDLHGDTWRVYDFVARNFIGSISAGLKYTTTTVNFLIGKEEFSCKGSSV 401
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
+ GF ++M W+ D++IP F KG + + V + EG T+PPDYLTE+ELI LME +GI
Sbjct: 402 TSLGFASVMHWMGRADEHIPEFKKGDVLHIESVSITEGKTSPPDYLTEAELIGLMEHHGI 461
Query: 307 GTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
GTDASIPVHINNIC+RNYVQV + RKLVPT LGI L+ G S +EQQ
Sbjct: 462 GTDASIPVHINNICQRNYVQVSGSSRKLVPTNLGIVLIHG--------------SDVEQQ 507
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ LIA G+ H V+ + ++ F++KF YF K I++MD LFEA FS L +GR LSKCGKC
Sbjct: 508 LNLIASGKASHKDVLDYFLKMFERKFEYFTKSIDSMDELFEATFSPLAATGRPLSKCGKC 567
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI+ +P+RL+C C+E Y LP G IKLY+EL CPLD+FEL+L S G G +P+
Sbjct: 568 KRYMKYIALKPNRLHCSTCDETYALPLNGNIKLYRELRCPLDDFELVLYSTGSKGTGYPI 627
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPE-- 543
CPYCY++PPFE N K GM C CPHPTCP+S+V+ +C CPE
Sbjct: 628 CPYCYNHPPFE------NYTK-----------GMSCNHCPHPTCPHSMVTNAICPCPESE 670
Query: 544 -----CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF- 597
C G+L+LD SAP+W+L CN CN + ++ K EC S +++++F
Sbjct: 671 NETDPCKGSLILDATSAPRWKLSCNECNIVSSFVDTVKNVNIIKNDMCECGSVLLKIEFR 730
Query: 598 -NKKATPLEDGSTLHRGCILCDELLHSLVEMK 628
N+ P+ GC++CD + +L+ +
Sbjct: 731 ENQNKEPM-------TGCVMCDSEIENLLTTR 755
>Q4Q888_LEIMA (tr|Q4Q888) Putative DNA topoisomerase III OS=Leishmania major
GN=LMJF_28_1780 PE=3 SV=1
Length = 866
Score = 575 bits (1482), Expect = e-161, Method: Compositional matrix adjust.
Identities = 283/629 (44%), Positives = 391/629 (62%), Gaps = 10/629 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I FKPE FW + P G +Q EW R +LFD
Sbjct: 198 LDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDE 257
Query: 67 NVATMFQKLVAEDG-LLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A + + + ++G + V +S +T+ RP GLNTV+L+K+AS ALG GPH M +AE
Sbjct: 258 TMARLILQRITKNGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAE 317
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LY +G+ISYPRTESTAYP SF+ G L+ Q N+ WG YV LL G+ +P+ G D GD
Sbjct: 318 NLYIRGYISYPRTESTAYPSSFNLAGTLAQQKNHSMWGAYVTTLLQQGHARPKAGKDAGD 377
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+ L D W++++YI +HFI +VSPDC+ + K+ +GGE F +G+
Sbjct: 378 HPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKV 437
Query: 246 VITKGFTAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V GFT IMP + D +P+ + KG ++S V L G T PP YLTES+LI LMEKN
Sbjct: 438 VEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKN 497
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASI H+NNI ER Y VQAGR + P+ LGI L+ G ++IDP+L LP +RS +E+
Sbjct: 498 GIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEE 557
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
+T IA+G+ V+ + + F KF +F + I+ DAL A FS + +G+ +++CG
Sbjct: 558 YVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGN 617
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C+RY+K++ +P RLYC CE + LPQ G IK Y +CP+DNFEL++C + GKSFP
Sbjct: 618 CMRYLKHLDTRPQRLYCPYCEVTFALPQGGAIKPYSSFTCPIDNFELVICHI-EGGKSFP 676
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAG-----MPCILCPHPTCPNSLVSQGVC 539
+CP+CY+NPPFE + I G M C C HPTC +SL + VC
Sbjct: 677 ICPHCYNNPPFEDMRPAIQHHDRGYGGGAATTMAPSTRHMACDECRHPTCEHSLATNYVC 736
Query: 540 ACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDF 597
C + C+G++ P +A +W++CCN C ++ L A R+ T E C EC ++ +++ F
Sbjct: 737 DCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTSEECSECAANCLDIMF 796
Query: 598 NKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ + L + CI C L L E
Sbjct: 797 PEGKSVLPNRKDRIVACIFCHPGLSPLCE 825
>C1N1P2_MICPC (tr|C1N1P2) Predicted protein OS=Micromonas pusilla (strain
CCMP1545) GN=MICPUCDRAFT_51680 PE=3 SV=1
Length = 862
Score = 571 bits (1472), Expect = e-160, Method: Compositional matrix adjust.
Identities = 298/681 (43%), Positives = 398/681 (58%), Gaps = 34/681 (4%)
Query: 4 FIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWS--VNPYIVHSGYEIQLEWQRS 61
+ L A SYGPCQTPTL F V+R+L I PE +W V + + L W R
Sbjct: 201 YAALDASVVSYGPCQTPTLNFAVERHLDIAKHVPEDYWVLCVTARSTETDEVVALRWNRE 260
Query: 62 KLFDINVATMFQKLVAEDGL---LEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPH 118
++FD + A +F++LV +D + +T + +E + RP GLNTV +LK AS+ LG G H
Sbjct: 261 RVFDRDAAELFKRLVVDDARANGVALTAFTRTEEKRPRPSGLNTVEMLKAASAGLGMGAH 320
Query: 119 MAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYL-KP 177
AMQ+AERLY GFISYPRTESTAYPP FD RG LSAQ ++P WG +V LL G + +P
Sbjct: 321 AAMQVAERLYISGFISYPRTESTAYPPGFDLRGTLSAQRHHPAWGEHVAELLDGGAMTRP 380
Query: 178 RLGTDVGDHPPITPMRPA-AEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGG 236
R G D GDHPPI P R A +E + G DAW+LY +I +HFI ++SPDC Y ++ F+ GG
Sbjct: 381 RGGKDEGDHPPIAPTRSATSERVGGGDAWRLYDFIARHFIASLSPDCAYDVQRASFACGG 440
Query: 237 ESFHCTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESE 296
E F GQ VI G+T +MPW AI + +P G K+ ++ VEL T+PP YL+ES+
Sbjct: 441 EGFAVVGQSVIEPGWTKMMPWRAIEEDPLPELTPGAKLAIAGVELTTSQTSPPPYLSESD 500
Query: 297 LISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLP 356
LISLMEKNGIGTDASIP HINN+ +R YV++ AGR++VPT LG+TL RGY +IDPDL LP
Sbjct: 501 LISLMEKNGIGTDASIPAHINNVEKRGYVKIGAGRRVVPTDLGVTLTRGYHAIDPDLALP 560
Query: 357 DIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSG 416
+R+ +E+Q+ LIA G+ H VV H ++QF KF FV ++ MD+LFEA FS +
Sbjct: 561 SMRASVEKQLDLIASGEATHAAVVAHALKQFAAKFHNFVANVDRMDSLFEAHFSPSASTE 620
Query: 417 RILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM 476
R SKCG C RY+K ++ P RLYC E VY LP G +KLY C L FELLL +
Sbjct: 621 RPFSKCGSCCRYLKLVTTTPQRLYCATQEAVYDLP-PGVVKLYHGRECVLCGFELLLLTS 679
Query: 477 GPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCIL---CPHPTCPNSL 533
G +++PLCPYC+++PP +G GA P L CPHP+ +
Sbjct: 680 G--DRTYPLCPYCFNHPPT----------------GMGHGARAPRRLVSGCPHPSAHPIV 721
Query: 534 VSQGVCACPEC----SGTLVLDPVSAPKWRLCCNMCNCLV-FLAQGAHRISTTKERCPEC 588
CPEC L+++PV + +L C+ C LV F + H++ T+ C C
Sbjct: 722 AELSTGPCPECDPDDDAVLLVEPVGGARHKLVCSECTLLVKFSEELTHKVCATEYECGGC 781
Query: 589 DSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXX 648
+EV + ++ TPL G T H C+ CD+LL S + +
Sbjct: 782 GGPCVEVTYKREKTPLAGGETRHVACVACDDLLRSQITLSRGRGGGGRGRGRGRGGRGGR 841
Query: 649 XXXXXXXXXXMVDPKMSFRDF 669
D KMSF++F
Sbjct: 842 GGRGGRKPASERDQKMSFKEF 862
>G0PNJ8_CAEBE (tr|G0PNJ8) DNA topoisomerase (Fragment) OS=Caenorhabditis brenneri
GN=CAEBREN_30446 PE=3 SV=1
Length = 671
Score = 571 bits (1471), Expect = e-160, Method: Compositional matrix adjust.
Identities = 285/622 (45%), Positives = 395/622 (63%), Gaps = 32/622 (5%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATM 71
SYGPCQTPTLGFCV R+ QI FKPE +W + EWQR ++FD +A +
Sbjct: 14 ISYGPCQTPTLGFCVTRHDQIVQFKPEAYWVLKTTFSCDSQTFSPEWQRGRIFDAEIARL 73
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
F + + VT++S+K+ K RP LNTV L++VASS+LG P M +AE LYTQG
Sbjct: 74 FVDRIKKSHSGVVTDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVAESLYTQG 133
Query: 132 FISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITP 191
+ISYPRTE+TAYP +FD G L + + WG+ V +L G +P+ G D GDHPPITP
Sbjct: 134 YISYPRTETTAYPANFDLNGTLKILSGDRKWGSVVSQVLAEGIKRPKSGVDKGDHPPITP 193
Query: 192 MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGF 251
MR A L D ++Y+Y+ QHF+ T+ C Y V+ + G E F G++VI GF
Sbjct: 194 MR-ANTGGLSGDMARIYEYVSQHFVATLMKQCVYEVTTVKMACGDEQFTIQGKNVIDPGF 252
Query: 252 TAIMPWLAINDK-NIPSFIK--GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGT 308
TA+MPWL++ D+ ++P ++ G KIE+ ++ TTPP YLTE+ELI+LMEK+GIGT
Sbjct: 253 TAVMPWLSVEDECSVPKSLQQVGAKIELQDAQILARETTPPGYLTEAELITLMEKHGIGT 312
Query: 309 DASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITL 368
DASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +R+ +E+Q+ L
Sbjct: 313 DASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLNL 372
Query: 369 IAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRY 428
+A G+ D+H V H ++ F+ KF +FV I A+D LFEA F+TL D+G+ S+CGKC RY
Sbjct: 373 VASGKADYHDVKNHALKMFEMKFQFFVNNIPAVDTLFEASFTTLSDTGKPFSRCGKCRRY 432
Query: 429 MKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK---SF 483
MK + +P RL+C C+E Y +P + G +K+ + CPLD+F+++L GP GK SF
Sbjct: 433 MKLVQTKPQRLFCPTCQETYSVPNFKDGVLKVIGDHKCPLDDFDVIL-YQGPGGKLARSF 491
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC-P 542
LCP+C++NPPFE K+ +G+G C C HP+C S+ S GVCAC
Sbjct: 492 TLCPFCFNNPPFE---------------KMPQGSG--CDNCTHPSCQYSISSNGVCACLQ 534
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKER-CPECDSSIIEVDF---N 598
+C G ++LD S PKWR+ CN C +V L GA ++ + + C EC S I+ + +
Sbjct: 535 DCGGVMLLDTQSHPKWRMTCNKCPSVVGLFDGATKVKVDRNKSCEECGSQFIKAELKPNS 594
Query: 599 KKATPLEDGSTLHRGCILCDEL 620
K +E S+ + GCI CD +
Sbjct: 595 GKPGAVEYDSSSYEGCIFCDAM 616
>F0VBK1_NEOCL (tr|F0VBK1) DNA topoisomerase OS=Neospora caninum (strain
Liverpool) GN=NCLIV_040590 PE=3 SV=1
Length = 924
Score = 568 bits (1465), Expect = e-159, Method: Compositional matrix adjust.
Identities = 294/648 (45%), Positives = 397/648 (61%), Gaps = 47/648 (7%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCVQRY I+ F+PE F++++ I E+ L+W+R ++FD
Sbjct: 254 LDASLVSYGPCQTPTLQFCVQRYDDIHAFQPETFYTLDTSIRVGEQELFLDWERGQVFDS 313
Query: 67 NVATMFQKLV-AEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA ++ +V A+ G+ V ++SEK+E RP LNTVN+LK+AS LG GP AMQ AE
Sbjct: 314 VVAHTYKDVVSAQGGVAVVVDVSEKEEKLPRPQALNTVNMLKLASQRLGMGPQQAMQTAE 373
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLY G ++YPRTE+ YP SFD RG +AQ +NP WG YV+ LL++G +PR G D GD
Sbjct: 374 RLYLSGIVTYPRTETCKYPDSFDLRGTAAAQTSNPYWGGYVKELLSSGLARPRDGVDAGD 433
Query: 186 HPPITPMRPAAE-DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPITP+R A E D+ G DAW LY+ I +HF+ ++SPDC++ +RKV FS+ E F +G+
Sbjct: 434 HPPITPVRSATEADVGGGDAWALYELITRHFLASISPDCRFLKRKVTFSVNDEIFSLSGR 493
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
H++ GFT +M + D +IP F KG ++ + KV + G T PP +L+ES+L+ LMEK+
Sbjct: 494 HMLDGGFTRVMRGDGMKDVSIPDFRKGDQVPLHKVAVGSGQTHPPPFLSESDLLGLMEKH 553
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDAS+ HINNICERNYV + + R+L PT LG+ LV GY +IDPDL LP RS +
Sbjct: 554 GIGTDASMATHINNICERNYVSLVSNRRLEPTKLGVCLVHGYMAIDPDLVLPSHRSPRRR 613
Query: 365 QITLIAKGQID--HHRVVQHVI----------------------QQFKQKFCYFVKKIEA 400
+ G+ + H+ + HV+ F ++ A
Sbjct: 614 YRSRQVGGRREGTGHQKLGHVLVEKLSALLSSHGASFPVCLSRASSFAHMKGRPRRRCHA 673
Query: 401 MDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYK 460
+ + Q L +G LS+CG+C RYM I+ +P+RL+C C E Y +P G IKLYK
Sbjct: 674 LAVHVQTQVCLLPSTGNALSRCGRCNRYMNLITKRPTRLHCRTCNETYNMPPNGAIKLYK 733
Query: 461 ELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMP 520
EL CPLDNFEL+L + GK+FPLCP CY++PP EG +N M
Sbjct: 734 ELRCPLDNFELVLFTQ-KGGKTFPLCPLCYNDPPLEGA---VNK--------------MS 775
Query: 521 CILCPHPTCPNSLVSQGVCAC--PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRI 578
C+ C HPTC +++ + GV C PEC G L LD VS PKW+L CN C V L +GAHRI
Sbjct: 776 CVECTHPTCKHAIEAVGVLQCPQPECKGILYLDVVSGPKWKLDCNACQYQVKLMEGAHRI 835
Query: 579 STTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVE 626
S T + C C S+++ V N K P +DG C +CD L++LVE
Sbjct: 836 SVTSDECDTCGSALLNVVMN-KTRPFKDGEIEKVACFVCDAELNALVE 882
>H1UBJ6_CAEEL (tr|H1UBJ6) DNA topoisomerase OS=Caenorhabditis elegans
GN=CELE_Y48C3A.14 PE=3 SV=1
Length = 733
Score = 568 bits (1463), Expect = e-159, Method: Compositional matrix adjust.
Identities = 288/623 (46%), Positives = 398/623 (63%), Gaps = 34/623 (5%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--GYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCV R+ QI FKPE++W + S G EWQR ++FD VA
Sbjct: 78 SYGPCQTPTLGFCVTRHDQIVQFKPEQYWVLKTNFTTSDDGQIFSPEWQRGRIFDAEVAR 137
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+F + + V ++S+K+ K RP LNTV L++VASS+LG P M +AE LYTQ
Sbjct: 138 VFVDRIKKCHTGLVLDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVAEALYTQ 197
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+TAY +FD G L A + WG+ V +L +G +P+ G D GDHPPIT
Sbjct: 198 GYISYPRTETTAYSANFDLTGTLKILAGDRKWGSVVSQVLADGIKRPKSGVDKGDHPPIT 257
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PMRP + G D ++Y+Y+ QHF+ T+ C Y V+ S G E F G++V+ G
Sbjct: 258 PMRPNHGGLSG-DMSRIYEYVSQHFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVVEPG 316
Query: 251 FTAIMPWLAINDK-NIPSFIK--GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIG 307
FTA+MPWL++ ++ ++P ++ G KIE+ E+ TTPP YLTE+ELI+LMEK+GIG
Sbjct: 317 FTAVMPWLSVEEECSVPKSLQQIGAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIG 376
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +R+ +E+Q+
Sbjct: 377 TDASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLN 436
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLR 427
L+A G+ D+ V H ++ F+ KF YFV I A+D LFEA F+TL D+G+ S+CGKC R
Sbjct: 437 LVASGKADYLDVKNHALKMFEMKFQYFVTNIPAVDTLFEASFTTLSDTGKPFSRCGKCRR 496
Query: 428 YMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK---S 482
YMK + +P RLYC C+E Y +P + G +K+ + CPLD+F+++L GP GK +
Sbjct: 497 YMKLVQTKPQRLYCPTCQETYAVPNFKDGVLKVIGDHKCPLDDFDVIL-YQGPGGKLART 555
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC- 541
F LCP+C++NPPFE K+ +GAG C C HP+C S+ S GVC C
Sbjct: 556 FTLCPFCFNNPPFE---------------KMPQGAG--CDTCVHPSCQYSISSNGVCGCL 598
Query: 542 PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKER-CPECDSSIIEVDF--- 597
+C G ++LD S PKWR+ CN C +V L +GA ++ R C +CD+ I+ +F
Sbjct: 599 QDCGGVMLLDTQSHPKWRMTCNKCPSVVGLFEGAIKVKVDSTRSCEQCDAQFIKAEFKPN 658
Query: 598 NKKATPLEDGSTLHRGCILCDEL 620
+ K +E S+ + GCI CD +
Sbjct: 659 SGKPGAIEYESSSYEGCIFCDAM 681
>H1UBJ9_CAEEL (tr|H1UBJ9) DNA topoisomerase OS=Caenorhabditis elegans
GN=CELE_Y48C3A.14 PE=3 SV=1
Length = 869
Score = 567 bits (1462), Expect = e-159, Method: Compositional matrix adjust.
Identities = 288/623 (46%), Positives = 398/623 (63%), Gaps = 34/623 (5%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--GYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCV R+ QI FKPE++W + S G EWQR ++FD VA
Sbjct: 214 SYGPCQTPTLGFCVTRHDQIVQFKPEQYWVLKTNFTTSDDGQIFSPEWQRGRIFDAEVAR 273
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+F + + V ++S+K+ K RP LNTV L++VASS+LG P M +AE LYTQ
Sbjct: 274 VFVDRIKKCHTGLVLDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVAEALYTQ 333
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+TAY +FD G L A + WG+ V +L +G +P+ G D GDHPPIT
Sbjct: 334 GYISYPRTETTAYSANFDLTGTLKILAGDRKWGSVVSQVLADGIKRPKSGVDKGDHPPIT 393
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PMRP + G D ++Y+Y+ QHF+ T+ C Y V+ S G E F G++V+ G
Sbjct: 394 PMRPNHGGLSG-DMSRIYEYVSQHFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVVEPG 452
Query: 251 FTAIMPWLAINDK-NIPSFIK--GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIG 307
FTA+MPWL++ ++ ++P ++ G KIE+ E+ TTPP YLTE+ELI+LMEK+GIG
Sbjct: 453 FTAVMPWLSVEEECSVPKSLQQIGAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIG 512
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +R+ +E+Q+
Sbjct: 513 TDASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLN 572
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLR 427
L+A G+ D+ V H ++ F+ KF YFV I A+D LFEA F+TL D+G+ S+CGKC R
Sbjct: 573 LVASGKADYLDVKNHALKMFEMKFQYFVTNIPAVDTLFEASFTTLSDTGKPFSRCGKCRR 632
Query: 428 YMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK---S 482
YMK + +P RLYC C+E Y +P + G +K+ + CPLD+F+++L GP GK +
Sbjct: 633 YMKLVQTKPQRLYCPTCQETYAVPNFKDGVLKVIGDHKCPLDDFDVIL-YQGPGGKLART 691
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC- 541
F LCP+C++NPPFE K+ +GAG C C HP+C S+ S GVC C
Sbjct: 692 FTLCPFCFNNPPFE---------------KMPQGAG--CDTCVHPSCQYSISSNGVCGCL 734
Query: 542 PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKER-CPECDSSIIEVDF--- 597
+C G ++LD S PKWR+ CN C +V L +GA ++ R C +CD+ I+ +F
Sbjct: 735 QDCGGVMLLDTQSHPKWRMTCNKCPSVVGLFEGAIKVKVDSTRSCEQCDAQFIKAEFKPN 794
Query: 598 NKKATPLEDGSTLHRGCILCDEL 620
+ K +E S+ + GCI CD +
Sbjct: 795 SGKPGAIEYESSSYEGCIFCDAM 817
>E3MMT0_CAERE (tr|E3MMT0) DNA topoisomerase OS=Caenorhabditis remanei
GN=CRE_04022 PE=3 SV=1
Length = 867
Score = 567 bits (1462), Expect = e-159, Method: Compositional matrix adjust.
Identities = 281/620 (45%), Positives = 393/620 (63%), Gaps = 30/620 (4%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTLGFCV R+ QI FKPE +W + EWQR ++FD +A +F
Sbjct: 214 SYGPCQTPTLGFCVTRHDQIVQFKPEAYWVLKTTFSCDSQTFSPEWQRGRIFDAEIARLF 273
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
+ + V ++S+K+ K RP LNTV L++VASS+LG P M +AE LYTQG+
Sbjct: 274 VDRIKKSHSGVVVDVSKKEARKERPCALNTVELMRVASSSLGLSPSTTMHVAESLYTQGY 333
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPM 192
ISYPRTE+TAYP +FD G L + + WG+ V +L G +P+ G D GDHPPITPM
Sbjct: 334 ISYPRTETTAYPANFDLNGTLKILSGDRKWGSVVSQVLAEGIKRPKSGVDKGDHPPITPM 393
Query: 193 RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFT 252
R ++ G D ++Y+Y+ QHF+ T+ C Y V+ G E F G++VI GFT
Sbjct: 394 RANTGNLSG-DMARIYEYVSQHFVATLMKQCVYEVTTVKMECGEEQFTIQGKNVIDPGFT 452
Query: 253 AIMPWLAINDK-NIPSFIK--GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTD 309
A+MPWL++ ++ ++P ++ G +IE+ ++ TTPP YLTESELI+LMEK+GIGTD
Sbjct: 453 AVMPWLSVEEECSVPKSLQQIGARIELQDAQIQARETTPPGYLTESELITLMEKHGIGTD 512
Query: 310 ASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLI 369
ASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +RS +E+Q+ L+
Sbjct: 513 ASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRSELEEQLNLV 572
Query: 370 AKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYM 429
A G+ D+H V H ++ F+ KF +FV I A+D LFEA F+TL D+G+ S+CGKC RYM
Sbjct: 573 ASGKADYHDVKNHALKMFEMKFQFFVNNIPAVDTLFEASFTTLSDTGKPFSRCGKCRRYM 632
Query: 430 KYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLC--SMGPDGKSFPL 485
K + +P RL+C C+E Y +P + G +K+ + CPLD+F+++L + G +SF L
Sbjct: 633 KLVQTKPQRLFCPTCQETYSVPNFKDGVLKVIGDHKCPLDDFDIILWQGAGGKLARSFTL 692
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCAC-PEC 544
CP+C++NPPFE K+ +G+G C C HP+C S+ S GVCAC +C
Sbjct: 693 CPFCFNNPPFE---------------KMPQGSG--CDNCVHPSCQYSISSNGVCACLQDC 735
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKER-CPECDSSIIEVDF---NKK 600
G ++LD S PKWR+ CN C +V L GA ++ + C EC S I+ +F + K
Sbjct: 736 GGVMLLDTQSHPKWRMTCNKCPSVVGLFDGALKVKVDRNNSCEECGSQFIKAEFKPNSGK 795
Query: 601 ATPLEDGSTLHRGCILCDEL 620
+E S+ + GCI CD +
Sbjct: 796 PGAVEYESSSYEGCIFCDAM 815
>E4X5F4_OIKDI (tr|E4X5F4) DNA topoisomerase OS=Oikopleura dioica
GN=GSOID_T00002389001 PE=3 SV=1
Length = 856
Score = 562 bits (1448), Expect = e-157, Method: Compositional matrix adjust.
Identities = 282/623 (45%), Positives = 380/623 (60%), Gaps = 24/623 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCV+R+ QI FKPEKFW ++ + + + +WQR ++FD VA
Sbjct: 206 ISYGPCQTPTLGFCVERHDQITKFKPEKFWRMSLAVQTENSGNLYADWQRGRIFDQGVAN 265
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
M + V +S+K + K RPV LNTV LL+V S+ LG GP AM AERLYTQ
Sbjct: 266 MLHGKIKNIKSAVVQSVSKKAKAKQRPVALNTVELLRVCSAKLGIGPAQAMVSAERLYTQ 325
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
GFISYPRTE+T+Y +FDFR +S ++ + L+ + PR G D GDHPPIT
Sbjct: 326 GFISYPRTETTSYSENFDFRPVISMLQHSTPHSIAAQELMKSS-PNPRKGEDKGDHPPIT 384
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P R +E +G +A+++Y Y+ HF+ ++ D KY + ++ +G E FH T KG
Sbjct: 385 PQRNCSETEVGGEAYRVYNYVASHFLASLMKDYKYEQTEITIKVGNEVFHLTANREKEKG 444
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
+ + + + + +P KG + V+ +L E T PPDYLTES+LI+LMEK+GIGTDA
Sbjct: 445 YALALTNVGVEESVLPDVQKGSSLNVASCQLEEKYTGPPDYLTESDLITLMEKHGIGTDA 504
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIPVHINNI +RNYVQ+ +GRKL PT LG+ LV GY+ IDPDL P +R+ +E+Q+ LIA
Sbjct: 505 SIPVHINNIVQRNYVQLVSGRKLEPTELGVVLVHGYKKIDPDLVKPQMRASVEKQLDLIA 564
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
G+ + +V +V+ +KF YFV I MD+L E +F++L +G+ SKCGKC R+MK
Sbjct: 565 AGKTEFKIMVDYVLNIMLRKFHYFVDHINMMDSLMETKFTSLSSAGKPFSKCGKCNRFMK 624
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLL-CSMGPDGKSFPLCPYC 489
I A+P RLYC C + Y LP IKLY+E CPLD+FELLL S G F +CPYC
Sbjct: 625 LIEAKPVRLYCPTCSDTYSLPSGLHIKLYQEKKCPLDDFELLLAASGGASSTGFAICPYC 684
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC-SGTL 548
Y+NPPF G+ PC C HP+C SL GV AC EC G +
Sbjct: 685 YNNPPFPGMP-----------------DPAPCSSCLHPSCSQSLRRTGVTACSECDDGVI 727
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLA--QGAHRISTTKERCPECDSSIIEVDFNKKATPLE- 605
LDP S PKWRL CN NC V + +GAH++ E C C++ I+ +F P
Sbjct: 728 YLDPSSKPKWRLSCNNINCKVVVKIFEGAHKVDVLDEACKTCETKILFCEFKSGKEPKAL 787
Query: 606 DGSTLHRGCILCDELLHSLVEMK 628
+G++ H+GCI CD + LV ++
Sbjct: 788 EGASTHKGCIFCDAIFSKLVSVR 810
>E4Y9R3_OIKDI (tr|E4Y9R3) DNA topoisomerase OS=Oikopleura dioica
GN=GSOID_T00030721001 PE=3 SV=1
Length = 856
Score = 561 bits (1447), Expect = e-157, Method: Compositional matrix adjust.
Identities = 282/623 (45%), Positives = 380/623 (60%), Gaps = 24/623 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCV+R+ QI FKPEKFW ++ + + + +WQR ++FD VA
Sbjct: 206 ISYGPCQTPTLGFCVERHDQITKFKPEKFWRMSLAVQTENSGNLYADWQRGRIFDQGVAN 265
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
M + V +S+K + K RPV LNTV LL+V S+ LG GP AM AERLYTQ
Sbjct: 266 MLHGKIKNIKSAVVQSVSKKAKAKQRPVALNTVELLRVCSAKLGIGPAQAMVSAERLYTQ 325
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
GFISYPRTE+T+Y +FDFR +S ++ + L+ + PR G D GDHPPIT
Sbjct: 326 GFISYPRTETTSYSENFDFRPVISMLQHSTPHSIAAQELMKSS-PNPRKGEDKGDHPPIT 384
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P R +E +G +A+++Y Y+ HF+ ++ D KY + ++ +G E FH T KG
Sbjct: 385 PQRNCSETEVGGEAYRVYNYVASHFLASLMKDYKYEQTEITVKVGNEVFHLTANREKEKG 444
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
+ + + + + +P KG + V+ +L E T PPDYLTES+LI+LMEK+GIGTDA
Sbjct: 445 YALALTNVGVEESVLPDVQKGSSLNVTSCQLEEKYTGPPDYLTESDLITLMEKHGIGTDA 504
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIPVHINNI +RNYVQ+ +GRKL PT LG+ LV GY+ IDPDL P +R+ +E+Q+ LIA
Sbjct: 505 SIPVHINNIVQRNYVQLVSGRKLEPTELGVVLVHGYKKIDPDLVKPQMRASVEKQLDLIA 564
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
G+ + +V +V+ +KF YFV I MD+L E +F++L +G+ SKCGKC R+MK
Sbjct: 565 AGKTEFKIMVDYVLNIMLRKFHYFVDHINMMDSLMETKFTSLSSAGKPFSKCGKCNRFMK 624
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLL-CSMGPDGKSFPLCPYC 489
I A+P RLYC C + Y LP IKLY+E CPLD+FELLL S G F +CPYC
Sbjct: 625 LIEAKPVRLYCPTCSDTYSLPSGLHIKLYQEKKCPLDDFELLLAASGGASSTGFAICPYC 684
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC-SGTL 548
Y+NPPF G+ PC C HP+C SL GV AC EC G +
Sbjct: 685 YNNPPFPGMP-----------------DPAPCSSCLHPSCSQSLRRTGVTACSECDDGVI 727
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLA--QGAHRISTTKERCPECDSSIIEVDFNKKATPLE- 605
LDP S PKWRL CN NC V + +GAH++ E C C++ I+ +F P
Sbjct: 728 YLDPSSKPKWRLSCNNINCKVVVKIFEGAHKVDVLDEACKTCETKILFCEFKSGKEPKAL 787
Query: 606 DGSTLHRGCILCDELLHSLVEMK 628
+G++ H+GCI CD + LV ++
Sbjct: 788 EGASTHKGCIFCDAIFSKLVSVR 810
>E4Y9S6_OIKDI (tr|E4Y9S6) DNA topoisomerase OS=Oikopleura dioica
GN=GSOID_T00030734001 PE=3 SV=1
Length = 856
Score = 560 bits (1442), Expect = e-156, Method: Compositional matrix adjust.
Identities = 281/623 (45%), Positives = 380/623 (60%), Gaps = 24/623 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCV+R+ QI FKPEKFW ++ + + + +WQR ++FD VA
Sbjct: 206 ISYGPCQTPTLGFCVERHDQITKFKPEKFWRMSLAVQTENSGNLYADWQRGRIFDQGVAN 265
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
M + V +S+K + K RPV LNTV LL+V S+ LG GP AM AERLYTQ
Sbjct: 266 MLHGKIKNIKSAVVQSVSKKAKAKQRPVALNTVELLRVCSAKLGIGPAQAMVSAERLYTQ 325
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+T+Y +FDFR +S ++ + L+ + PR G D GDHPPIT
Sbjct: 326 GYISYPRTETTSYSENFDFRPVISMLQHSTPHSIAAQELMKSS-PNPRKGEDKGDHPPIT 384
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P R +E +G +A+++Y Y+ HF+ ++ D KY + ++ +G E FH T KG
Sbjct: 385 PQRNCSETEVGGEAYRVYYYVASHFLASLMKDYKYEQTEITVKVGNEVFHLTANREKEKG 444
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
+ + + + + +P KG + V+ +L E T PPDYLTES+LI+LMEK+GIGTDA
Sbjct: 445 YALALTNVGVEESVLPDVQKGSSLNVTSCQLEEKYTGPPDYLTESDLITLMEKHGIGTDA 504
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIA 370
SIPVHINNI +RNYVQ+ +GRKL PT LG+ LV GY+ IDPDL P +R+ +E+Q+ LIA
Sbjct: 505 SIPVHINNIVQRNYVQLVSGRKLEPTELGVVLVHGYKKIDPDLVKPQMRASVEKQLDLIA 564
Query: 371 KGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMK 430
G+ + +V +V+ +KF YFV I MD+L E +F++L +G+ SKCGKC R+MK
Sbjct: 565 AGKTEFKIMVDYVLNIMLRKFHYFVDHINMMDSLMETKFTSLSSAGKPFSKCGKCNRFMK 624
Query: 431 YISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLL-CSMGPDGKSFPLCPYC 489
I A+P RLYC C + Y LP IKLY+E CPLD+FELLL S G F +CPYC
Sbjct: 625 LIEAKPVRLYCPTCSDTYSLPSGLHIKLYQEKKCPLDDFELLLAASGGASSTGFAICPYC 684
Query: 490 YSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC-SGTL 548
Y+NPPF G+ PC C HP+C SL GV AC EC G +
Sbjct: 685 YNNPPFPGMP-----------------DPAPCSSCLHPSCSQSLRRTGVTACSECDDGVI 727
Query: 549 VLDPVSAPKWRLCCNMCNCLVFLA--QGAHRISTTKERCPECDSSIIEVDFNKKATPLE- 605
LDP S PKWRL CN NC V + +GAH++ E C C++ I+ +F P
Sbjct: 728 YLDPSSKPKWRLSCNNINCKVVVKIFEGAHKVDVLDEACKTCETKILFCEFKSGKEPKAL 787
Query: 606 DGSTLHRGCILCDELLHSLVEMK 628
+G++ H+GCI CD + LV ++
Sbjct: 788 EGASTHKGCIFCDAIFSKLVSVR 810
>H2MSA1_ORYLA (tr|H2MSA1) DNA topoisomerase OS=Oryzias latipes PE=3 SV=1
Length = 786
Score = 559 bits (1441), Expect = e-156, Method: Compositional matrix adjust.
Identities = 282/597 (47%), Positives = 381/597 (63%), Gaps = 36/597 (6%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 213 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWILQAKVFKGKDGPLTLDWSRVRVFD 272
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
V MF L +V +S+K++TK RP LNTV +L+VASSALG GP MQ+AE
Sbjct: 273 REVGQMFVNLAKMSKEAKVEAVSQKEKTKQRPQALNTVEMLRVASSALGMGPQHTMQIAE 332
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G L QAN+P W V+ LL+ G +PR G DVG+
Sbjct: 333 RLYTQGYISYPRTETTQYPENFDLKGTLRQQANSPMWAEEVKALLSAGLNRPRKGNDVGN 392
Query: 186 HPPITPM----RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHC 241
PP P +P D+LG+D W+LY+YI +HFI TVS DC+Y + +EFSIG E F C
Sbjct: 393 RPPPPPPQVLRKPVTSDILGSDGWRLYEYITRHFIATVSQDCRYLQSTIEFSIGTERFSC 452
Query: 242 TGQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISL 300
G+ I+ G+TA+MPW + ++ +P+ G V ++ L E T PPDYLTE+ELI+L
Sbjct: 453 GGKTPISPGYTALMPWQGVPLEEALPTCQPGDAFTVDELRLVERQTGPPDYLTEAELITL 512
Query: 301 MEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRS 360
MEK+GIGTDASIPVHINN+C+RNYV V+ GR+L PT LG+ LV GY I +
Sbjct: 513 MEKHGIGTDASIPVHINNVCQRNYVTVETGRRLKPTNLGVVLVHGYYKIG------GVLH 566
Query: 361 FIEQQITLIAKGQID-HHRVVQHVIQQFKQKFCYFVKKIEA-----MDALFEAQFSTLVD 414
FI +++ K + + + ++ I+ + ++ A MD L E FS +
Sbjct: 567 FILEKMFSECKNKTNILSKFLEDAIRSRRTGVFVLIEPCGAVAPAGMDELMEVSFSPIAA 626
Query: 415 SGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLC 474
+G+ LS+CGKC R+MKYI A+PSRL+C C+E Y +PQ G IKLYKEL CPLD+FEL+L
Sbjct: 627 TGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYNVPQNGAIKLYKELRCPLDDFELVLW 686
Query: 475 SMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLV 534
+ G GKS+PLCPYC+SNPPF ++ GM C C HP+C +SL
Sbjct: 687 TSGARGKSYPLCPYCFSNPPFRDMK-----------------KGMGCNECTHPSCQHSLS 729
Query: 535 SQGVCACPEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDS 590
+ G+ C EC SG LVLDP S PKWR+ CN CN LV L + AH++ +++ C CD+
Sbjct: 730 ALGIGQCVECESGVLVLDPTSGPKWRMACNRCNVLVHLFEHAHKVQVSQDSCEVCDA 786
>A8PGM1_BRUMA (tr|A8PGM1) DNA topoisomerase OS=Brugia malayi GN=Bm1_24915 PE=3
SV=1
Length = 858
Score = 553 bits (1426), Expect = e-155, Method: Compositional matrix adjust.
Identities = 290/634 (45%), Positives = 394/634 (62%), Gaps = 31/634 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWS-VNPYIVHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV R+ I FKPE +W V + +G ++ R ++FD
Sbjct: 210 LDSTTISFGPCQTPTLGFCVTRHDLITQFKPEPYWILVAIFETSAGDTLKPTHVRGRIFD 269
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+V +F + + V ++ + K RP LNTV LLKVASS LG P M AE
Sbjct: 270 KDVCQLFFDRIKKQNQGVVVDVISSELRKERPQALNTVELLKVASSGLGLSPTQTMSTAE 329
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LYT+GFISYPRTE+TAYP +FDF AL Q N+ W + V+ LL+ G KPR G D GD
Sbjct: 330 YLYTRGFISYPRTETTAYPSNFDFSEALRHQQNDSRWKDIVKKLLSEGITKPRNGEDKGD 389
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPI+P+R + L DA K+Y Y+ QHFI T+ C Y + ++ +I E F +
Sbjct: 390 HPPISPLR-GNDGSLTGDALKIYDYVTQHFIATLMQPCIYLVKSIKINIANEIFIAKSKC 448
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
VI G+T IM W I D + +KG K+ + ++ E TTPPDYLTESELISLMEK+
Sbjct: 449 VINLGYTEIMVWQKIEEDTQNYNIVKGSKLNLKDAKICEYATTPPDYLTESELISLMEKH 508
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHI+NIC+RNYV V++ R+L PT LGI LV GY ID +L LP +RS +E
Sbjct: 509 GIGTDASIPVHISNICQRNYVTVESKRRLKPTKLGIALVHGYWRIDSELVLPTMRSEVES 568
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIAKG D V HV++ F+ KF YF + I +D+LFE F++L SG+ S+CGK
Sbjct: 569 QLNLIAKGYADFCSVKNHVLENFRLKFIYFAENISLVDSLFEDSFTSLAASGKPFSRCGK 628
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK- 481
C R+MK ++++P RL+C C++ Y LP + G ++L+ E CPLD+F+L+ GP GK
Sbjct: 629 CRRFMKLVASKPQRLHCPNCQDTYSLPSAKDGLLRLHGENKCPLDDFDLIYW-QGPGGKL 687
Query: 482 --SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVC 539
S+ LCPYCY+NPPFEG++ KG+G C C +P CP+S ++ GV
Sbjct: 688 SMSYVLCPYCYNNPPFEGMK---------------KGSG--CHECCNPVCPHSFLTLGVV 730
Query: 540 ACP-ECS---GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEV 595
CP C G LVLDP SAPKWR+ CN C+ +V L +GA R+ ++C +C + +
Sbjct: 731 QCPRRCGAGHGVLVLDPQSAPKWRISCNKCSAVVGLFEGALRVKVLTKQCEDCGAQLFFA 790
Query: 596 DFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
++ K +PL + T +RGC+ CD+ + LV H
Sbjct: 791 EYKDK-SPLPEERTTYRGCVFCDKSISHLVNFNH 823
>D8LYS1_BLAHO (tr|D8LYS1) DNA topoisomerase OS=Blastocystis hominis
GN=GSBLH_T00001006001 PE=3 SV=1
Length = 891
Score = 552 bits (1423), Expect = e-154, Method: Compositional matrix adjust.
Identities = 300/642 (46%), Positives = 382/642 (59%), Gaps = 30/642 (4%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKF--WSVNPY-IVHSGYEIQLEWQRS-KLFDINV 68
SYGPCQ PTLGFCV R+ I FK E F + +P ++ + Q + RS L
Sbjct: 208 SYGPCQIPTLGFCVDRFDLIQNFKGEAFPRFHFSPAALLDAERHRQEKLPRSPALLGARP 267
Query: 69 AT--MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
A+ +F + +A L V + E + RPV +NTV +LK+AS +LG GP A AER
Sbjct: 268 ASFFVFSRKLASVSSLTVLSVRESNGARVRPVPMNTVTMLKLASRSLGMGPKEATVYAER 327
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LY +G+ISYPRTE+TAYP ++ GA+ NP WG YV L+ G PR G D GDH
Sbjct: 328 LYLKGYISYPRTETTAYPEHYNLLGAVEQHRTNPRWGGYVNALIAGGLRVPRKGVDAGDH 387
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITP+ L + LY I HF+ TVS DCK+ V F G E+F + + V
Sbjct: 388 PPITPVVSVDPSTLPSGESALYDLIATHFLATVSDDCKFVTTFVRFGGGDETFSYSYRRV 447
Query: 247 ITKGFTAIMPWL---AINDKNIPS----------FIKGQKIEVSKVELYEGTTTPPDYLT 293
GFTA+ +D+N S F KG+ +EV ++ +G T+ P YLT
Sbjct: 448 TQPGFTALYHSQFEDESDDENDASEAELAMEAYSFQKGEVVEVDRIAERDGYTSAPGYLT 507
Query: 294 ESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDL 353
ESELISLMEKNGIGTDASIPVHI NI ERNYV + R L+PT LGI L+ G SIDP+L
Sbjct: 508 ESELISLMEKNGIGTDASIPVHIANILERNYVSLGPKRTLIPTKLGIVLIHGIYSIDPEL 567
Query: 354 CLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLV 413
LP +R IE++ LIAKG+ VV H + FKQKF YF + I MDALFE++FS LV
Sbjct: 568 VLPIVRGNIEKECALIAKGKAKMDDVVDHALLVFKQKFIYFKEHIADMDALFESEFSLLV 627
Query: 414 DSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLL 473
DSG+ LS+CG C R+MKY+ P RLYC C Y LP GTIKLYKEL CPLD F+LLL
Sbjct: 628 DSGKPLSRCGICKRFMKYVKNPPPRLYCAQCNVTYNLPPNGTIKLYKELKCPLDGFDLLL 687
Query: 474 CSMGPD----GKSFPLCPYCYSNPPFEGIEALINTA-KTSTSGKIG---KGAGMPCILCP 525
S G G ++PLCP+CY+NPPF+G+ ++ TA + G I + A C
Sbjct: 688 YSRGNSERFVGVTYPLCPFCYNNPPFDGMSLMVRTAGRVERRGAINVFIRHANSDCWRTA 747
Query: 526 HPTCPNSLVSQGVCACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERC 585
CPN + V +C+G +VLD S P W+LCCN CN + H + K+RC
Sbjct: 748 CSRCPN---EEDVDGEAKCNGMMVLDLESRPNWKLCCNQCNMIFRFTANLHDVQVMKKRC 804
Query: 586 PECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEM 627
EC+SS+++V FNK +TPL G T + GCILCDELL L+EM
Sbjct: 805 EECESSLLKVSFNKNSTPLPGGETEYSGCILCDELLSGLIEM 846
>E1G0B3_LOALO (tr|E1G0B3) DNA topoisomerase OS=Loa loa GN=LOAG_06591 PE=3 SV=2
Length = 859
Score = 550 bits (1418), Expect = e-154, Method: Compositional matrix adjust.
Identities = 288/634 (45%), Positives = 393/634 (61%), Gaps = 31/634 (4%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNP-YIVHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV R+ I F+PE +W + + +G ++ + ++FD
Sbjct: 208 LDSTTISFGPCQTPTLGFCVTRHDLITQFEPESYWVLETVFETSAGDNLKPIHAKGRIFD 267
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+V +F + + V ++ + K RP LNTV LL+VASS LG P M AE
Sbjct: 268 KDVCQLFFDRIKKQNQGVVVDVDSSEFRKERPQALNTVELLRVASSGLGLSPAQTMNTAE 327
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LYT+GFISYPRTE+TAYP +FDF AL Q N+ W + V+ LL+ G PR G D GD
Sbjct: 328 YLYTRGFISYPRTETTAYPSNFDFSEALRHQQNDIRWKDIVKKLLSEGITTPRNGEDKGD 387
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPI+P+R + L DA K+Y YI QHFI T+ C Y V+ I E F +
Sbjct: 388 HPPISPLR-GNDGSLTGDALKVYDYIAQHFIATLMKPCTYLVTSVKIDIANEVFIAKSKC 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I G+T IM W I D + +KG K+ + ++ E TTPPDYLTESELISLMEK+
Sbjct: 447 IINLGYTEIMVWQKIEEDPQNYNIVKGTKVNLKDGKICEYATTPPDYLTESELISLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHI+NIC+RNYV V++ R+L PT LGI LV GY ID +L LP +RS +E
Sbjct: 507 GIGTDASIPVHISNICQRNYVTVESRRRLKPTKLGIALVHGYWKIDSELVLPTMRSEVES 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIAKG D V HV++ F+ KF YFV+ I +D+LFE F++L SG+ S+CGK
Sbjct: 567 QLNLIAKGYADFCSVKNHVLENFRLKFIYFVENIGLVDSLFEDSFTSLAASGKPFSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK- 481
C R+MK ++++P RL+C C++ Y LP + G ++L+ E CPLD+F+L+ GP GK
Sbjct: 627 CRRFMKLVASKPQRLHCPNCQDTYSLPSAKDGLLRLHGENKCPLDDFDLIYW-QGPGGKL 685
Query: 482 --SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVC 539
S+ LCPYCY+NPPFEG+ KG+G C C +P CP+S ++ GV
Sbjct: 686 SMSYALCPYCYNNPPFEGMR---------------KGSG--CHECSNPVCPHSFLTLGVV 728
Query: 540 ACP-ECS---GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEV 595
CP +C G LVLDP SAPKWR+ CN C+ +V + +GA R+ ++C C + + V
Sbjct: 729 QCPRQCDAGHGVLVLDPQSAPKWRISCNRCSAVVAVFEGALRVKILAKQCMSCGAQLFFV 788
Query: 596 DFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
++ K +PL + T +RGCI CD+ + LV + H
Sbjct: 789 EY-KDRSPLPEERTTYRGCIFCDKSISHLVNLNH 821
>G0UCD3_TRYVY (tr|G0UCD3) Putative DNA topoisomerase III OS=Trypanosoma vivax
(strain Y486) GN=TVY486_1109690 PE=3 SV=1
Length = 782
Score = 549 bits (1415), Expect = e-153, Method: Compositional matrix adjust.
Identities = 272/580 (46%), Positives = 365/580 (62%), Gaps = 18/580 (3%)
Query: 50 SGYEIQLEWQRSKLFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVA 109
SG +I EW R ++FD +A + + V+ + + +V ++S +T++RP LNTV L+KVA
Sbjct: 180 SGAQITFEWVRGRVFDELIARLLHQKVSHNKVGKVVDVSVGADTRARPTALNTVELMKVA 239
Query: 110 SSALGFGPHMAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGL 169
S LG GPH AMQLAE LY G+ISYPRTESTAYP SFDF+GAL+ +P WG YV+GL
Sbjct: 240 SKLLGIGPHHAMQLAENLYVSGYISYPRTESTAYPSSFDFKGALAQHERHPQWGAYVQGL 299
Query: 170 LTNGYLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRK 229
L + Y +P+ G D GDHPPITPMR A L +D+W+LY+YI +HFI T+SPDCK + K
Sbjct: 300 LKDRYTRPKAGKDAGDHPPITPMRAANPGELSSDSWRLYEYITRHFIATLSPDCKLCKTK 359
Query: 230 VEFSIGGESFHCTGQHVITKGFTAIMPWLAINDKNIPSFIK-GQKIEVSKVELYEGTTTP 288
+ +GGE F TG+ V GFT I+ A+ D IP+ I+ G +S V L G T P
Sbjct: 360 LVVELGGEFFTFTGKVVEDPGFTEILSHFAVKDDKIPTNIQVGSDFPMSDVRLQAGQTQP 419
Query: 289 PDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQS 348
P YLTES+LI +ME++GIGTDASI H+NNI ER Y V+ GR + PT LGI L+ G +S
Sbjct: 420 PGYLTESDLIGMMERHGIGTDASISQHVNNIVERGYCTVKPGRVMQPTKLGIVLIHGIKS 479
Query: 349 IDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQ 408
IDP+L LP +RS +E+ +TLIA+G+ V+ V+ F KF YF + IE DAL A
Sbjct: 480 IDPELVLPLVRSKVEEYVTLIAEGKAGLDEVLSSVLDLFFGKFRYFKENIERFDALMGAS 539
Query: 409 FSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDN 468
F++L SG+ +++CG C+RY+K++ A+P RLYC CE Y LPQ GTIK Y CPLDN
Sbjct: 540 FTSLAASGKPITRCGNCMRYLKHLEARPQRLYCPYCEVTYALPQGGTIKQYSSYKCPLDN 599
Query: 469 FELLLCSMGPDGKSFPLCPYCYSNPPF-EGIEALINTAKTSTSGKIGKGAGMPCILCPHP 527
FEL++C + GKSFP+CP CY+NPPF E IE G M C C HP
Sbjct: 600 FELVICHID-GGKSFPICPNCYNNPPFDESIER-------------GGRKVMACDECRHP 645
Query: 528 TCPNSLVSQGVCAC--PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERC 585
TC +SL V C C G + P S+ KW++CCN C ++ L A R+ + E C
Sbjct: 646 TCAHSLAKNYVADCIDERCDGCMAFVPRSSGKWKICCNHCTMMILLPPTAQRVYVSSEEC 705
Query: 586 PECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLV 625
EC + ++++ F + +PL + C+ CD + S V
Sbjct: 706 KECGAMMMDLQFPEGQSPLANRKDRVVACVFCDPTISSSV 745
>A8J6M3_CHLRE (tr|A8J6M3) DNA topoisomerase (Fragment) OS=Chlamydomonas
reinhardtii GN=CHLREDRAFT_138607 PE=3 SV=1
Length = 644
Score = 544 bits (1402), Expect = e-152, Method: Compositional matrix adjust.
Identities = 253/435 (58%), Positives = 318/435 (73%), Gaps = 1/435 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTL FCV+R+ I +F+PE FW+V P +G ++LEW+R ++FD
Sbjct: 210 LDASVISYGPCQTPTLNFCVERHQAITSFQPEPFWAVRPRASKAGVPLELEWERGRVFDQ 269
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+V M+ LV + L V ++ EK++ KSRP GLNTV LLK AS++LG GP AMQ+AER
Sbjct: 270 DVGGMYAALVRDAKRLRVVDVGEKEDRKSRPHGLNTVELLKYASASLGLGPAHAMQVAER 329
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
LYT G++SYPRTES+AYPP+FD G ++A N+P +G Y LL G P+ GTDVGDH
Sbjct: 330 LYTSGYLSYPRTESSAYPPNFDINGNVAALRNHPVFGGYASALLQQGIKHPQGGTDVGDH 389
Query: 187 PPITPMRPAAEDMLGN-DAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
PPITP+R A E LG DAW++Y Y+ +HF+G+VSPD Y + K F GGE F TG
Sbjct: 390 PPITPVRSATETELGGGDAWRVYDYVARHFLGSVSPDAVYRKTKAVFEAGGEMFTATGCV 449
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
V+ GFT+IMPW A ++P G+ + S+VELY+G T+PPDYLTES+LI LMEK G
Sbjct: 450 VVKPGFTSIMPWRATQSDSLPPLSPGEHLTCSEVELYQGRTSPPDYLTESDLIGLMEKYG 509
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHINNICERNYV +QAGRK+VPT LGITL+RGYQ IDP+LC P +R+ +EQQ
Sbjct: 510 IGTDASIPVHINNICERNYVSIQAGRKVVPTELGITLIRGYQLIDPELCKPQVRAHVEQQ 569
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ LIAKG+ D VV H ++QF+ KF +FV + MD+LFEA FS L SG+ LSKCGKC
Sbjct: 570 LDLIAKGKADKEAVVAHTVEQFRAKFLFFVSHVTRMDSLFEASFSPLASSGKPLSKCGKC 629
Query: 426 LRYMKYISAQPSRLY 440
RYMKYISA+P RLY
Sbjct: 630 RRYMKYISARPQRLY 644
>H9JJ16_BOMMO (tr|H9JJ16) Uncharacterized protein OS=Bombyx mori PE=3 SV=1
Length = 823
Score = 527 bits (1357), Expect = e-147, Method: Compositional matrix adjust.
Identities = 274/625 (43%), Positives = 370/625 (59%), Gaps = 74/625 (11%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFD 65
L A SYGPCQTPTLGFCVQR+ +I TFKPE +W + S G E+ LEW+R + F+
Sbjct: 206 LDASLISYGPCQTPTLGFCVQRHDEIQTFKPETYWVLRVTASTSEGRELPLEWKRVRSFE 265
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
++A MF + E V I K++ K+RP LNTV L++VAS+ LG GPH AM
Sbjct: 266 KDIANMFLSGIKECKEATVINIQAKEKVKARPTALNTVELMRVASAGLGMGPHHAM---- 321
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
AQ+++ WG V L++NG KP+ G D GD
Sbjct: 322 -----------------------------AQSSS-KWGAEVRALISNGINKPKKGHDAGD 351
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITP+R A+E L D W++Y Y+ +HFI T+S DCK+ + F I E+FH TG
Sbjct: 352 HPPITPLRAASESELEGDMWRIYDYVTRHFIATLSRDCKFLSTTITFRIAAETFHYTGNA 411
Query: 246 VITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ G+T +M W A D+ +P+ + L E T PPDYLTESE+I+LMEK+
Sbjct: 412 LLDAGYTELMHWQAFGKDEFVPTLHVDDVLRAHDHRLVECQTAPPDYLTESEVITLMEKH 471
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V +GR+LVPT LGI LV GYQ IDP+L LP +RS +E+
Sbjct: 472 GIGTDASIPVHINNICQRNYVTVGSGRRLVPTNLGIVLVHGYQKIDPELVLPTMRSAVEE 531
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA G+ D H V+ H + F++KF YFV+ IE MD LFE FS+L SG+ LS+CGK
Sbjct: 532 QLNLIAVGRADFHAVLSHTTEIFRRKFQYFVRSIEGMDQLFEVSFSSLKASGKALSRCGK 591
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFP 484
C RYM+YI A+P+RL+C C++ Y LPQ GT+++Y+EL CPLD+FELL S G GKSFP
Sbjct: 592 CRRYMRYIQAKPARLHCSHCDDTYCLPQNGTVRIYRELKCPLDDFELLSWSSGSKGKSFP 651
Query: 485 LCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC 544
LCPYCY++PPF ++ KG G C C HPTCP + GV C E
Sbjct: 652 LCPYCYNHPPFRDMK---------------KGFG--CNSCTHPTCPYGVNWTGVSGCVE- 693
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
C+ ++ + + A R+S ++ C C + ++ V++ + T L
Sbjct: 694 --------------------CDVIINIFEDAARVSVCEQACAACGAQLVAVEYRTERTRL 733
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
T C+ C+ + +L + K
Sbjct: 734 PAALTEMTACLYCEPIFSALAKSKQ 758
>H2SPY9_TAKRU (tr|H2SPY9) Uncharacterized protein OS=Takifugu rubripes
GN=LOC101062441 PE=3 SV=1
Length = 665
Score = 521 bits (1343), Expect = e-145, Method: Compositional matrix adjust.
Identities = 243/458 (53%), Positives = 324/458 (70%), Gaps = 2/458 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE-IQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FK E +W + + + L+W R ++FD
Sbjct: 207 LDSSLISFGPCQTPTLGFCVERHDKIQSFKAETYWILQAKVFKGKDNPLTLDWSRVRVFD 266
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
V MF L +V +S+K++ K RP LNTV +L+VAS ALG GP MQ+AE
Sbjct: 267 REVGQMFINLTKTSREAQVVSVSKKEKVKQRPQALNTVEMLRVASQALGMGPQHTMQIAE 326
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLY QG+ISYPRTE+T YP +FD + AL Q+N+ W V+ LL+ G +PR G+D GD
Sbjct: 327 RLYVQGYISYPRTETTHYPENFDLKAALKQQSNSSMWAEEVKALLSGGLNRPRKGSDAGD 386
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A+E LG+D W+LY+YI +HFI TVS DC+Y + ++F IG E+F CTG+
Sbjct: 387 HPPITPMRSASEAELGSDGWRLYEYITRHFIATVSQDCRYLQTTIDFLIGTEAFSCTGKT 446
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I+ GFTA+MPW +I ++++P+ +G V +++L E T PPDYLTE+ELI+LMEK+
Sbjct: 447 LISAGFTALMPWQSIPLEESLPACERGDVFTVDEIKLVEKQTKPPDYLTEAELITLMEKH 506
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC RNYV V++GR+L PT LGI LV GY D +L LP IRS +E+
Sbjct: 507 GIGTDASIPVHINNICLRNYVTVESGRRLKPTNLGIVLVHGYYKTDAELVLPTIRSAVEK 566
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA G+ + +V+QH + FK+KF YFV I +MD L E FS + ++G+ LS+CGK
Sbjct: 567 QLNLIALGRANFQQVLQHTLDIFKRKFHYFVDAISSMDELMEVSFSPIAETGKPLSRCGK 626
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKEL 462
C R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL
Sbjct: 627 CHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKEL 664
>H3CHY5_TETNG (tr|H3CHY5) Uncharacterized protein OS=Tetraodon nigroviridis
GN=TOP3B (1 of 2) PE=3 SV=1
Length = 773
Score = 519 bits (1336), Expect = e-144, Method: Compositional matrix adjust.
Identities = 247/466 (53%), Positives = 323/466 (69%), Gaps = 16/466 (3%)
Query: 166 VEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKY 225
V+ LL+ G +PR GTD GDHPPITPMR A+E LG D W+LY+YI +HFI TVS DCKY
Sbjct: 322 VKALLSEGLNRPRKGTDAGDHPPITPMRSASEAELGCDGWRLYEYITRHFIATVSQDCKY 381
Query: 226 ARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEG 284
+ ++F+IG E+F C+G+ +++ GFTA+MPW I ++ +P+ G V +++L E
Sbjct: 382 LQTTIDFNIGTEAFSCSGKTLMSAGFTALMPWQNIPLEEAMPTCECGDTFTVDEIKLVEK 441
Query: 285 TTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVR 344
T+PPDYLTE+ELI+LMEK+GIGTDASIPVHINNIC+RNYV V++GRKL PT LGI LV
Sbjct: 442 QTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRKLKPTNLGIVLVH 501
Query: 345 GYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDAL 404
GY ID +L LP IRS +E+Q+ LIA G+ ++ +V+ H ++ FK+KF YFV I MD L
Sbjct: 502 GYYKIDAELVLPTIRSAVEKQLNLIALGRANYQQVLHHTLEIFKRKFHYFVDVITGMDEL 561
Query: 405 FEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSC 464
E FS + ++G+ LS+CGKC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL C
Sbjct: 562 MEVSFSPIAETGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELRC 621
Query: 465 PLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILC 524
PLD+FEL+L + G GKS+PLCPYC+SNPPF ++ GM C C
Sbjct: 622 PLDDFELVLWTSGARGKSYPLCPYCFSNPPFRDMKKAY--------------LGMGCNEC 667
Query: 525 PHPTCPNSLVSQGVCACPEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKE 583
HP+C +SL S G+ C EC SG LVLDP S PKW++ CN CN +V + AHR+ +E
Sbjct: 668 THPSCQHSLNSFGIGQCVECDSGVLVLDPTSGPKWKMACNKCNVVVHFFEHAHRVQVAQE 727
Query: 584 RCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
C CD+S++ VDFNK + L T H GC+ CD + VE+KH
Sbjct: 728 SCDTCDASLVAVDFNKTHSELPSCETQHTGCVFCDPIFQDAVELKH 773
>Q4T0Q4_TETNG (tr|Q4T0Q4) Chromosome undetermined SCAF10893, whole genome shotgun
sequence. (Fragment) OS=Tetraodon nigroviridis
GN=GSTENG00009201001 PE=3 SV=1
Length = 449
Score = 517 bits (1332), Expect = e-144, Method: Compositional matrix adjust.
Identities = 247/466 (53%), Positives = 323/466 (69%), Gaps = 19/466 (4%)
Query: 166 VEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKY 225
V+ LL+ G +PR GTD GDHPPITPMR A+E LG D W+LY+YI +HFI TVS DCKY
Sbjct: 1 VKALLSEGLNRPRKGTDAGDHPPITPMRSASEAELGCDGWRLYEYITRHFIATVSQDCKY 60
Query: 226 ARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEG 284
+ ++F+IG E+F C+G+ +++ GFTA+MPW I ++ +P+ G V +++L E
Sbjct: 61 LQTTIDFNIGTEAFSCSGKTLMSAGFTALMPWQNIPLEEAMPTCECGDTFTVDEIKLVEK 120
Query: 285 TTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVR 344
T+PPDYLTE+ELI+LMEK+GIGTDASIPVHINNIC+RNYV V++GRKL PT LGI LV
Sbjct: 121 QTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRKLKPTNLGIVLVH 180
Query: 345 GYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDAL 404
GY ID +L LP IRS +E+Q+ LIA G+ ++ +V+ H ++ FK+KF YFV I MD L
Sbjct: 181 GYYKIDAELVLPTIRSAVEKQLNLIALGRANYQQVLHHTLEIFKRKFHYFVDVITGMDEL 240
Query: 405 FEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSC 464
E FS + ++G+ LS+CGKC R+MKYI A+PSRL+C C+E Y LPQ G IKLYKEL C
Sbjct: 241 MEVSFSPIAETGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYSLPQNGAIKLYKELRC 300
Query: 465 PLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILC 524
PLD+FEL+L + G GKS+PLCPYC+SNPPF ++ GM C C
Sbjct: 301 PLDDFELVLWTSGARGKSYPLCPYCFSNPPFRDMK-----------------KGMGCNEC 343
Query: 525 PHPTCPNSLVSQGVCACPEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKE 583
HP+C +SL S G+ C EC SG LVLDP S PKW++ CN CN +V + AHR+ +E
Sbjct: 344 THPSCQHSLNSFGIGQCVECDSGVLVLDPTSGPKWKMACNKCNVVVHFFEHAHRVQVAQE 403
Query: 584 RCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
C CD+S++ VDFNK + L T H GC+ CD + VE+KH
Sbjct: 404 SCDTCDASLVAVDFNKTHSELPSCETQHTGCVFCDPIFQDAVELKH 449
>A4RZ61_OSTLU (tr|A4RZ61) DNA topoisomerase OS=Ostreococcus lucimarinus (strain
CCE9901) GN=OSTLU_32265 PE=3 SV=1
Length = 863
Score = 517 bits (1332), Expect = e-144, Method: Compositional matrix adjust.
Identities = 279/640 (43%), Positives = 376/640 (58%), Gaps = 47/640 (7%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI--VHSGYEIQLEWQRSKLF 64
L A SYGPCQTPTLGF VQR+L+I PE +W+++ +G I W+R++LF
Sbjct: 222 LDARVVSYGPCQTPTLGFAVQRHLEIIRHVPEPYWALDASFDDAATGDTIAPAWRRTRLF 281
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D F +LV + VT I E + RP GLNTV +LK AS+ LG G H AMQ+A
Sbjct: 282 DEETTRAFLQLVNDANEFRVTSIEVNAEKRGRPSGLNTVEMLKAASAGLGMGAHRAMQVA 341
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYL-KPRLGTDV 183
ERLY G ISYPRTESTAYP F+ + L+ Q ++PTWG +V LL + P+ G D
Sbjct: 342 ERLYMAGHISYPRTESTAYPRGFELKQTLTIQKSHPTWGAFVSRLLDESSMTSPKRGVDA 401
Query: 184 GDHPPITPMRPAAEDMLGN-DAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPMR + ED +G +AW+LY +I +HFI +VSPDC+Y + GGE F
Sbjct: 402 GDHPPITPMRASTEDQVGGGEAWRLYDFISRHFIASVSPDCEYETQTATLDAGGEEFTLQ 461
Query: 243 GQHVITKGFTAIMPWLAINDKNIPS-FIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ VI G+T IMP I D ++P ++G +I + V L +T+PP+YLTESELI LM
Sbjct: 462 GKRVIEHGWTEIMPHRMIEDSSLPVCVVQGARIPLKSVRLRSESTSPPEYLTESELIGLM 521
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
EKNGIGTDASIP HINNI R YV V GR++VP+ LGITLV+GY +ID +L LP +R
Sbjct: 522 EKNGIGTDASIPTHINNIQVRKYVDVAKGRRIVPSQLGITLVQGYHAIDSELVLPTVRRH 581
Query: 362 IEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
+E+Q+ L+AKGQ + VV H++ Q KF YF I AMDALFEA FS SK
Sbjct: 582 VERQLDLVAKGQAPYEGVVAHILAQMFDKFNYFTTNIAAMDALFEASFSHTTTESTPYSK 641
Query: 422 CGKCLRYMKYISA--QPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPD 479
CG+C RY+K + A + RLYC E VY LP G K + +C + FELL+ S
Sbjct: 642 CGRCSRYLKLVGATGRIQRLYCPTEEVVYELPIGGVFKQHNGRTCAICGFELLIVSQKGT 701
Query: 480 GKSFPLCPYCYSNPPFEG---IEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQ 536
G+++PLCP+C+++PPFEG I+AL+ + PHP
Sbjct: 702 GRAYPLCPFCFNHPPFEGAPRIKALLRGS-------------------PHPREHPVADDV 742
Query: 537 GVCACPECS-----GTLVLDPVSAPKWRLCCN--MCNCLVFLAQGAHRISTTKE-RCPEC 588
V CPEC+ G L+LDP + +L C+ C+ LV L R + + + C C
Sbjct: 743 SVSTCPECAASNRPGVLMLDPAATSPGKLYCSSAACDVLVRLPPSVKRSAVSHDAECAAC 802
Query: 589 DSSIIEVD-FNKKATPLEDGSTLHRGCILCDELLHSLVEM 627
++ ++++ FN D +T+ C+ C++ L V +
Sbjct: 803 EAKCLDLEMFNG------DKATV---CLRCEDELSESVRV 833
>G0MZ90_CAEBE (tr|G0MZ90) DNA topoisomerase OS=Caenorhabditis brenneri
GN=CAEBREN_32330 PE=3 SV=1
Length = 1276
Score = 513 bits (1320), Expect = e-142, Method: Compositional matrix adjust.
Identities = 249/526 (47%), Positives = 341/526 (64%), Gaps = 27/526 (5%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATM 71
SYGPCQTPTLGFCV R+ QI FKPE +W + EWQR ++FD +A +
Sbjct: 758 ISYGPCQTPTLGFCVTRHDQIVQFKPEAYWVLKTTFSCDSQTFSPEWQRGRIFDAEIARL 817
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
F + + VT++S+K+ K RP LNTV L++VASS+LG P M +AE LYTQG
Sbjct: 818 FVDRIKKSHSGVVTDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVAESLYTQG 877
Query: 132 FISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITP 191
+ISYPRTE+TAYP +FD G L + + WG+ V +L G +P+ G D GDHPPITP
Sbjct: 878 YISYPRTETTAYPANFDLNGTLKILSGDRKWGSVVSQVLAEGIKRPKSGVDKGDHPPITP 937
Query: 192 MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGF 251
MR A L D ++Y+Y+ QHF+ T+ C Y V+ + G E F G++VI GF
Sbjct: 938 MR-ANTGGLSGDMARIYEYVSQHFVATLMKQCVYEVTTVKMACGDEQFTIQGKNVIDPGF 996
Query: 252 TAIMPWLAINDK-NIPSFIK--GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGT 308
TA+MPWL++ D+ ++P ++ G KIE+ ++ TTPP YLTE+ELI+LMEK+GIGT
Sbjct: 997 TAVMPWLSVEDECSVPKSLQQVGAKIELQDAQILARETTPPGYLTEAELITLMEKHGIGT 1056
Query: 309 DASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITL 368
DASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +R+ +E+Q+ L
Sbjct: 1057 DASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLNL 1116
Query: 369 IAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRY 428
+A G+ D+H V H ++ F+ KF +FV I A+D LFEA F+TL D+G+ S+CGKC RY
Sbjct: 1117 VASGKADYHDVKNHALKMFEMKFQFFVNNIPAVDTLFEASFTTLSDTGKPFSRCGKCRRY 1176
Query: 429 MKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK---SF 483
MK + +P RL+C C+E Y +P + G +K+ + CPLD+F+++L GP GK SF
Sbjct: 1177 MKLVQTKPQRLFCPTCQETYSVPNFKDGVLKVIGDHKCPLDDFDVILY-QGPGGKLARSF 1235
Query: 484 PLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTC 529
LCP+C++NPPFE K+ G+G C C HP+C
Sbjct: 1236 TLCPFCFNNPPFE---------------KMPPGSG--CDNCTHPSC 1264
>B6ADG7_CRYMR (tr|B6ADG7) DNA topoisomerase OS=Cryptosporidium muris (strain
RN66) GN=CMU_007480 PE=3 SV=1
Length = 857
Score = 505 bits (1301), Expect = e-140, Method: Compositional matrix adjust.
Identities = 270/623 (43%), Positives = 375/623 (60%), Gaps = 32/623 (5%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI-NVAT 70
SYGPCQTPTL F VQR +I F PEKF+ +N I + + W+R K+FD+ ++
Sbjct: 233 LSYGPCQTPTLFFVVQRRDKILGFSPEKFYYLNVTIEYKDIILSPTWERKKIFDLQSIQC 292
Query: 71 MFQKLVAEDGLL-EVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYT 129
++ + + ++ +V +I +K + SRP+ LNTV +LK+AS+ LG P AM +AE+LY
Sbjct: 293 LYNTVNSTYPIIAKVIDIKKKADRISRPLPLNTVQMLKLASNILGISPFQAMNIAEKLYL 352
Query: 130 QGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRL-GTDVGDHPP 188
GFI+YPRTE+T YP SFD + A S ++P WG Y +L Y PR G DVGDHPP
Sbjct: 353 SGFITYPRTETTKYPKSFDTKEAASIHKDHPLWGQYTCDILARNYTNPRQDGIDVGDHPP 412
Query: 189 ITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVIT 248
I P+R + L D W+LY+ I +HF+ T+SPD K+ V F I GE F G+ +
Sbjct: 413 IVPIRSVISNDLAGDNWRLYELITRHFLATISPDIKFTNEFVIFDINGEKFTLQGRRINE 472
Query: 249 KGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGT 308
GF+ I +IN +IP G K+ + +E+ G T PP L+E L+SLMEKNGIGT
Sbjct: 473 YGFSIIYKSKSINSISIPQLDLGMKLNLKSIEICNGETKPPPLLSEGNLLSLMEKNGIGT 532
Query: 309 DASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITL 368
DAS+PVHI + ER YV + GRKL PT LG L+ GY +ID +L P IRS +E+ I+L
Sbjct: 533 DASMPVHIQKLIERKYVNIIDGRKLEPTRLGNALIHGYMNIDIELVYPMIRSEMERYISL 592
Query: 369 IAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRY 428
I++G+ + V++H + FK KF +FVK I + ++LF+ F+ L SG LSKCG+C RY
Sbjct: 593 ISQGKANAGNVLKHTLAIFKLKFLFFVKNITSFESLFQLSFTNLSSSGTRLSKCGQCKRY 652
Query: 429 MKYIS-AQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCP 487
M YIS P +LYC CE LP G++KLYKEL CPLD++ELL+ + K+ LCP
Sbjct: 653 MTYISNTNPPKLYCSFCEINLKLPSGGSLKLYKELKCPLDDYELLVFNSLRTKKNMILCP 712
Query: 488 YCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP--EC- 544
CY++PPF+ A+ N + C CPHPTCP+S S + CP +C
Sbjct: 713 RCYNDPPFDS--AIQN---------------ILCKECPHPTCPHSYNSSFIMYCPVEKCK 755
Query: 545 SGTLVLDPVSAPKWRLCCNMCN-CLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G L LD SAP WR+ C+ CN L F + H++STT + C C + I+ ++ N +P
Sbjct: 756 DGVLTLDLSSAPNWRIDCSNCNFVLKFREKHCHKVSTTNDYCNNCGARILLINLN---SP 812
Query: 604 LEDGSTLHRGCILCDELLHSLVE 626
E GC +C E ++ L+E
Sbjct: 813 KESII----GCPICLERINELIE 831
>E5SGB5_TRISP (tr|E5SGB5) DNA topoisomerase OS=Trichinella spiralis GN=Tsp_06514
PE=3 SV=1
Length = 819
Score = 498 bits (1282), Expect = e-138, Method: Compositional matrix adjust.
Identities = 253/607 (41%), Positives = 345/607 (56%), Gaps = 35/607 (5%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSG--YEIQLEWQRSKLFDINVA 69
SYGPCQTPTLGFCV R ++ FKPE +WS+ + G + W R +LFD V
Sbjct: 157 ISYGPCQTPTLGFCVARLDEMKNFKPEPYWSMRAVVTSDGGGSTMTASWARQQLFDQEVF 216
Query: 70 TMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYT 129
+ V ++ ++ K +P LNTV LL+V SS L GP M LAE LYT
Sbjct: 217 NVLFSRAKRQRFATVVSVTTTKKQKQKPAALNTVELLRVGSSRLHLGPQQTMHLAEHLYT 276
Query: 130 QGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPI 189
G ISYPRTE+T Y +FDF L A + + + + +L G P+ G D GDHPPI
Sbjct: 277 NGLISYPRTETTRYASNFDFHSVLGPLAKSGQFASVAQAILDRGVRMPKSGQDAGDHPPI 336
Query: 190 TPMRPAAE-DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVIT 248
TP+ E +LY+Y+ HF+ T+ +C Y R ++ + GE F T I
Sbjct: 337 TPLGHVGEPKFTSTSEARLYEYVVCHFLATLMGNCVYELRTIQLDLAGERFTLTSSRPID 396
Query: 249 KGFTAIMPWLAI--NDKNIPSFIK-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
GFT + W + N+ ++P+ + G + V + + +G T+PPD+LTE+ELI+LME++G
Sbjct: 397 PGFTEVFTWQQVTANENSLPATVNVGDRWNVVDLLMDQGQTSPPDHLTETELITLMERHG 456
Query: 306 IGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
IGTDASIPVHINNIC+RNYV VQ + R+LVPT LG+ LV GY ID L ++RS IE
Sbjct: 457 IGTDASIPVHINNICQRNYVTVQESSRRLVPTQLGVILVHGYWKIDCQLVEAEMRSAIEH 516
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA GQ + + +H++ F +KF YFV+ + MDALFE F TL DSG+ S+CG+
Sbjct: 517 QLMLIADGQANPASMKEHILDIFTKKFHYFVENVALMDALFEDTFQTLADSGKPFSRCGR 576
Query: 425 CLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKL--YKELSCPLDNFELLLCSMGPDGKS 482
C RYMK + RL+C C+ Y LP+ TI + CPLD F+L+ C G +G
Sbjct: 577 CRRYMKIVLQGKKRLFCATCQLTYPLPRGSTISFRPLNDAKCPLDGFDLIYCVNGGNGGD 636
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
LCPYCYSNPPFE + C C HPTCP S + V C
Sbjct: 637 HALCPYCYSNPPFEDMR-----------------PEQACNRCTHPTCPYSSRTLAVAICE 679
Query: 543 ECS---------GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSII 593
C+ G+L+LDP SAPKW+LCCN C V + +GA + T + CP+C+S ++
Sbjct: 680 YCARTAAKSAFRGSLLLDPGSAPKWQLCCNQCKFKVRIFKGAKMVRVTDDHCPQCNSRLV 739
Query: 594 EVDFNKK 600
V + ++
Sbjct: 740 HVIYTQE 746
>L1JH36_GUITH (tr|L1JH36) DNA topoisomerase OS=Guillardia theta CCMP2712
GN=GUITHDRAFT_69656 PE=3 SV=1
Length = 807
Score = 497 bits (1279), Expect = e-138, Method: Compositional matrix adjust.
Identities = 266/594 (44%), Positives = 358/594 (60%), Gaps = 30/594 (5%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGY-EIQLEWQRSKLFDINVATM 71
SYGPCQTPTLGFCV+R++ I F PE +W + P I GY ++ EW+R ++FD VA++
Sbjct: 212 SYGPCQTPTLGFCVERHILIQNFVPEPYWVLCPTIKIEGYGAVKFEWERGRIFDKRVASV 271
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
F+ ++ ED L++ +++K+ K RP LNTV +LK S ALG GP AM AE LY QG
Sbjct: 272 FRSIMLEDSRLKILRVNQKEVKKGRPTPLNTVAMLKACSKALGIGPASAMHTAENLYLQG 331
Query: 132 FISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITP 191
+ISYPRTESTAYP S + L + + WG +V+ LL ++ P+ G DVGDHPPITP
Sbjct: 332 YISYPRTESTAYPKSMNIEETLRQFSRHAIWGGFVDDLLPRNWVTPKSGVDVGDHPPITP 391
Query: 192 MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGF 251
R A L +D ++Y I +HFI TVSPD Y + K+E IG E+F +G+ + G+
Sbjct: 392 CRLAQPGDLSSDQGRVYDLIAKHFIATVSPDAVYLQTKIEAQIGTENFTTSGRQLKRPGW 451
Query: 252 TAIMPWLAIND-------KNIPSFIKGQKIEVSK--VELYEGTTTPPDYLTESELISLME 302
+ + + +N+PSF G+ +++ + + E T+PP YLTESELI+LME
Sbjct: 452 LGLYQMRSEYEDEENYEIRNLPSFKGGETFQMTSETLPMVEKKTSPPGYLTESELIALME 511
Query: 303 KNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
KNGIGTDAS+ HI NIC+RNYV V++GR+LVPT LG LV+GY ID DL LP +RS I
Sbjct: 512 KNGIGTDASMATHIENICQRNYVNVESGRRLVPTQLGTVLVQGYYRIDADLVLPIVRSNI 571
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E+Q LIAKG D VV H + F++KF YFVK IE MD LFEA FS L G+ SKC
Sbjct: 572 EKQCDLIAKGMADKDDVVAHSLSNFQKKFSYFVKNIEMMDTLFEASFSPLTAGGKPWSKC 631
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLD--NFELLL--CSMGP 478
G RY++ I ++P RLY E+VY LPQ G+ KL+ CP++ FEL L G
Sbjct: 632 GLSNRYLQLIQSKPQRLYNKNTEQVYNLPQGGSFKLWGGRVCPVEGCGFELSLFVVGAGK 691
Query: 479 DGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGV 538
D +S+PLCP CY+NP E A S+ G + + CPH + +
Sbjct: 692 DQRSYPLCPNCYNNPRPEWGPA------PSSKGLMTE--------CPHADFHPVVAKLTL 737
Query: 539 CACPECSGTLVLDPVSAP-KWRLCCNMCN-CLVFLAQGAHRISTTKERCPECDS 590
C E +G +LDP SAP WRL N L F + H+++ E P C++
Sbjct: 738 CDDEETNGVFILDPGSAPNNWRLVSTRSNFMLTFPSDVVHKLTVLSETDPACEN 791
>Q7YYF5_CRYPV (tr|Q7YYF5) DNA topoisomerase OS=Cryptosporidium parvum GN=1MB.260
PE=3 SV=1
Length = 835
Score = 492 bits (1266), Expect = e-136, Method: Compositional matrix adjust.
Identities = 259/623 (41%), Positives = 367/623 (58%), Gaps = 32/623 (5%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL F VQR IN+F PEK+++++ + +I L W RS++F++ VA F
Sbjct: 210 SYGPCQTPTLFFTVQRRDSINSFIPEKYYTISATLSKDSQDINLIWSRSRVFELQVANCF 269
Query: 73 QKLVAEDGLL--EVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+L+ L V +I+ K + RP+ LNTV++LK++S+ LG GP + +AE+LY
Sbjct: 270 LQLIQNKKPLSARVVDITSKNSRRIRPLPLNTVSMLKLSSTILGIGPFQTLNIAEKLYLS 329
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRL-GTDVGDHPPI 189
GF +YPRTE++ YP +FD + ++ NN WG+Y LL G+ PR G D+GDHPPI
Sbjct: 330 GFTTYPRTETSRYPKNFDIKSTIAMFKNNSVWGSYSSDLLQKGFNLPRKDGLDLGDHPPI 389
Query: 190 TPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITK 249
TP+R A ++ L D+W+LY I +HF T+S D K R ++F + GE F +G VI
Sbjct: 390 TPVRSATQNDLDGDSWRLYDLITRHFFATISNDIKMINRTIKFDLNGEIFIISGNQVIDH 449
Query: 250 GFTAIMPWLAINDKNI-PSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGT 308
GF+ I A ++ NI P F + + + +E+ T PP L+ES+L+SLMEK+GIGT
Sbjct: 450 GFSVIQGRAACHESNIIPDFTLNEVVPIKNIEILSKETKPPPILSESDLLSLMEKHGIGT 509
Query: 309 DASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITL 368
DAS+P HI I ER YV++ +GR+L PT LGI LV G +ID +L LP IRS +E+ + L
Sbjct: 510 DASMPTHIQKIQEREYVKLASGRRLEPTKLGIALVHGIMNIDHELVLPKIRSEMEKYVDL 569
Query: 369 IAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRY 428
IAKG+ +H V++H + FK KF YF + I ++LF F+ + S +S+CG+C RY
Sbjct: 570 IAKGKYNHKAVLKHSLSVFKLKFLYFAENISLFESLFRLGFTNITASCSRISRCGQCKRY 629
Query: 429 MKYISA-QPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCP 487
+ YIS P RLYC CE +PQ+GTIK+YKEL CP+D+FELLL + GK CP
Sbjct: 630 LTYISNILPQRLYCSFCEIYLDIPQRGTIKIYKELKCPIDDFELLLF-IDQKGKKSIFCP 688
Query: 488 YCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP--EC- 544
CY++PPF + M C CPH TC SL S ACP +C
Sbjct: 689 RCYNDPPF-----------------LDAKENMLCKFCPHQTCNFSLKSTFFMACPSQDCR 731
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
G + +D S WR C+ C+ + + + ERC +C S +++ K+ T
Sbjct: 732 DGIITMDSSSTSDWRFDCSRCSISFSIKKNICERLSLGERCEKCGSRKLKI--CKEKTSQ 789
Query: 605 EDGSTLHRGCILCDELLHSLVEM 627
E GC CDE + SL+E+
Sbjct: 790 EH----FVGCPNCDEEILSLIEV 808
>A3FPU5_CRYPI (tr|A3FPU5) DNA topoisomerase OS=Cryptosporidium parvum (strain
Iowa II) GN=cgd6_2390 PE=3 SV=1
Length = 835
Score = 492 bits (1266), Expect = e-136, Method: Compositional matrix adjust.
Identities = 259/623 (41%), Positives = 367/623 (58%), Gaps = 32/623 (5%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL F VQR IN+F PEK+++++ + +I L W RS++F++ VA F
Sbjct: 210 SYGPCQTPTLFFTVQRRDSINSFIPEKYYTISATLSKDSQDINLIWSRSRVFELQVANCF 269
Query: 73 QKLVAEDGLL--EVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+L+ L V +I+ K + RP+ LNTV++LK++S+ LG GP + +AE+LY
Sbjct: 270 LQLIQNKKPLSARVVDITSKNSRRIRPLPLNTVSMLKLSSTILGIGPFQTLNIAEKLYLS 329
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRL-GTDVGDHPPI 189
GF +YPRTE++ YP +FD + ++ NN WG+Y LL G+ PR G D+GDHPPI
Sbjct: 330 GFTTYPRTETSRYPKNFDIKSTIAMFKNNSVWGSYSSDLLQKGFNLPRKDGLDLGDHPPI 389
Query: 190 TPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITK 249
TP+R A ++ L D+W+LY I +HF T+S D K R ++F + GE F +G VI
Sbjct: 390 TPVRSATQNDLDGDSWRLYDLITRHFFATISNDIKMINRTIKFDLNGEIFIISGNQVIDH 449
Query: 250 GFTAIMPWLAINDKNI-PSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGT 308
GF+ I A ++ NI P F + + + +E+ T PP L+ES+L+SLMEK+GIGT
Sbjct: 450 GFSVIQGRAACHESNIIPDFTLNEVVPIKNIEILSKETKPPPILSESDLLSLMEKHGIGT 509
Query: 309 DASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITL 368
DAS+P HI I ER YV++ +GR+L PT LGI LV G +ID +L LP IRS +E+ + L
Sbjct: 510 DASMPTHIQKIQEREYVKLASGRRLEPTKLGIALVHGIMNIDHELVLPKIRSEMEKYVDL 569
Query: 369 IAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRY 428
IAKG+ +H V++H + FK KF YF + I ++LF F+ + S +S+CG+C RY
Sbjct: 570 IAKGKYNHKAVLKHSLSVFKLKFLYFAENISLFESLFRLGFTNITASCSRISRCGQCKRY 629
Query: 429 MKYISA-QPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCP 487
+ YIS P RLYC CE +PQ+GTIK+YKEL CP+D+FELLL + GK CP
Sbjct: 630 LTYISNILPQRLYCSFCEIYLDIPQRGTIKIYKELKCPIDDFELLLF-IDQKGKKSIFCP 688
Query: 488 YCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP--EC- 544
CY++PPF + M C CPH TC SL S ACP +C
Sbjct: 689 RCYNDPPF-----------------LDAKENMLCKFCPHQTCNFSLKSTFFMACPSQDCR 731
Query: 545 SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
G + +D S WR C+ C+ + + + ERC +C S +++ K+ T
Sbjct: 732 DGIITMDSSSTSDWRFDCSRCSISFSIKKNICERLSLGERCEKCGSRKLKI--CKEKTSQ 789
Query: 605 EDGSTLHRGCILCDELLHSLVEM 627
E GC CDE + SL+E+
Sbjct: 790 EH----FVGCPNCDEEILSLIEV 808
>H2YRK6_CIOSA (tr|H2YRK6) Uncharacterized protein (Fragment) OS=Ciona savignyi
PE=3 SV=1
Length = 452
Score = 490 bits (1262), Expect = e-136, Method: Compositional matrix adjust.
Identities = 241/469 (51%), Positives = 316/469 (67%), Gaps = 22/469 (4%)
Query: 166 VEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDMLG-NDAWKLYQYICQHFIGTVSPDCK 224
V LL+ G+ KPR G+D GDHPPITPM A E +G +D+W+LY+YI +HFI T+SPDC
Sbjct: 1 VSSLLSTGFTKPRKGSDAGDHPPITPMLCATEQEIGGHDSWRLYEYIVRHFIATLSPDCT 60
Query: 225 YARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAIND-KNIPSFIKGQKIEVSKVELYE 283
Y V+F I E+F CTG + GFT +MPW +IND + +P+ G + V + EL +
Sbjct: 61 YMHTVVQFKIADETFTCTGSLPLKAGFTEVMPWQSINDHQTLPTLQTGDECSVERAELLD 120
Query: 284 GTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLV 343
T+PPDYLTESELI+LMEK+GIGTDASIP HINNI +RNYV V +GRKL PT LGI LV
Sbjct: 121 RKTSPPDYLTESELITLMEKHGIGTDASIPTHINNIGQRNYVTVISGRKLQPTNLGIMLV 180
Query: 344 RGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDA 403
GY ID DL P +RS +E+Q+ LIA+G+ + V++H + F+QKF YFV + ++D+
Sbjct: 181 HGYNKIDADLVQPTMRSAVEKQLNLIAQGKAKYTDVLKHAVTIFQQKFHYFVANVTSVDS 240
Query: 404 LFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELS 463
LFE F+ L +SG+ +S+CGKC R+MKYI+A P RLYC C+E Y LP K +KLYKEL
Sbjct: 241 LFEVTFTPLSESGKPISRCGKCRRFMKYIAAAPPRLYCNTCDETYDLPFKTNVKLYKELK 300
Query: 464 CPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCIL 523
CPLD FELL+CS G +GK++ LCPYC+++PPF ++ KG+G C
Sbjct: 301 CPLDEFELLVCSTGSNGKTYTLCPYCFNHPPFRDMK---------------KGSG--CNS 343
Query: 524 CPHPTCPNSLVSQGVCACPEC-SGTLVLDPVSAPKWRLCC--NMCNCLVFLAQGAHRIST 580
C HP C +S + GV C C SG LVLDP S+PKW+L C N C +V L Q AHRIS
Sbjct: 344 CSHPDCEHSRSALGVAPCMVCESGILVLDPTSSPKWKLACNDNKCPTVVTLFQDAHRISV 403
Query: 581 TKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
E C +C + + V+F+K TPLE+ T H GCI CD + SL+++K
Sbjct: 404 NDETCEKCGAYELAVNFHKDKTPLENKETKHNGCIFCDPIFSSLIKLKQ 452
>H9KK00_APIME (tr|H9KK00) Uncharacterized protein (Fragment) OS=Apis mellifera
PE=3 SV=1
Length = 476
Score = 488 bits (1255), Expect = e-135, Method: Compositional matrix adjust.
Identities = 237/454 (52%), Positives = 308/454 (67%), Gaps = 20/454 (4%)
Query: 178 RLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGE 237
+ G +VGDHPPITPM+ A + L D W+LY YI +HFI T++ DCKY ++F IG E
Sbjct: 2 KKGCNVGDHPPITPMKHATRNELDGDTWRLYDYITRHFIATLAHDCKYLSTTIKFEIGME 61
Query: 238 SFHCTGQHVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESE 296
F G ++ G+T+I+ W A+ ++ N+P F G+K+ + +++L E T PPDYLTESE
Sbjct: 62 IFTANGHSLLDPGYTSILTWQALGSNDNLPRFTPGEKVNIQEIKLVECYTQPPDYLTESE 121
Query: 297 LISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLP 356
LISLMEK+GIGTDASIPVHINNIC RNYV V GRKLVPT+LGI LV GYQ IDP+L LP
Sbjct: 122 LISLMEKHGIGTDASIPVHINNICMRNYVNVATGRKLVPTSLGIVLVHGYQKIDPELVLP 181
Query: 357 DIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSG 416
+RS +E+Q+ LIA G+ D H V+QH ++ FKQKF YFVK IEAMD LFE FS L SG
Sbjct: 182 TMRSAVEEQLNLIALGRADFHAVLQHTVEIFKQKFHYFVKNIEAMDQLFEVSFSPLSASG 241
Query: 417 RILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM 476
+ S+CGKC RYMKYI +PSR++C C E Y LPQ G I++YKEL CPLD+FELL S
Sbjct: 242 KAHSRCGKCRRYMKYIQTKPSRMHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSWST 301
Query: 477 GPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQ 536
G GKSF CPYCY+NPPF + K SG C C HPTCP+ + S
Sbjct: 302 GARGKSFTFCPYCYNNPPFRDM-------KKGISG---------CNSCTHPTCPHGMNSN 345
Query: 537 GVCACPEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEV 595
G+ +C EC +G LVLDP +APKW+L CN C+ ++ L + AH+++ E C EC + ++ V
Sbjct: 346 GISSCLECNAGILVLDPSAAPKWKLGCNRCDVIIHLFENAHKVTVDTEVC-ECGAQLVTV 404
Query: 596 DFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
++ ++ + L + ST GC+ C +LVE KH
Sbjct: 405 EYKQEKSKLPNESTEMTGCVFCTPAFMALVE-KH 437
>H3G0S1_PRIPA (tr|H3G0S1) DNA topoisomerase OS=Pristionchus pacificus PE=3 SV=1
Length = 849
Score = 487 bits (1254), Expect = e-135, Method: Compositional matrix adjust.
Identities = 256/633 (40%), Positives = 367/633 (57%), Gaps = 49/633 (7%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFD 65
L + S+GPCQTPTL FCV R+ QI FKPE +W + S ++ EW+R ++FD
Sbjct: 209 LDSSVISFGPCQTPTLAFCVTRHDQIVQFKPEPYWVIQTTFEDSEKTAMRAEWERGRIFD 268
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
VA MF + + + G V ++S K+ K RP LNTV L++VAS++LG P M +AE
Sbjct: 269 REVAGMFLERIKKAGGATVVDVSTKKSAKERPQALNTVELMRVASASLGLSPATTMHVAE 328
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
LYT G+ISYPRTE+T+YP +FD +G L Q + WG +L++G KPR G D GD
Sbjct: 329 SLYTHGYISYPRTETTSYPANFDLKGTLMQQTGDKVWGKIASQVLSDGINKPRGGDDKGD 388
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPMR A +LG D+ ++Y+Y+ +HFI T+ +C Y V+ + G E F G+
Sbjct: 389 HPPITPMR-AGGAVLGGDSARVYEYVVRHFIATLMRNCTYDVTTVKLACGEEEFSFLGRQ 447
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I GFT PW ++ D+ P+ KGQK+ + E+ T+PP YLTESELI+LMEK+
Sbjct: 448 LIDPGFTVAFPWAGVDEDERAPNVKKGQKLGLKSAEIVSRETSPPGYLTESELITLMEKH 507
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDP--DLCLPDIRSFI 362
GIGTDASIPVHIN IC+RNYV T L ++ P +L LP +R+ +
Sbjct: 508 GIGTDASIPVHINTICQRNYV----------TNL-------FEICSPVTELVLPTMRAEL 550
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E Q+ LI+KG+ D+ V H ++QF++KF +FV+ + +D+LF F+TL ++G+ S+C
Sbjct: 551 ETQLNLISKGEADYLAVKNHALEQFRRKFVFFVQNVTRVDSLF-VSFTTLTEAGKPFSRC 609
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCS--MGP 478
GKC R+MK + ++P+RLYC C + Y +P + G++K + CPLD F+LL G
Sbjct: 610 GKCRRFMKLVESRPARLYCSNCHDAYPVPSGRDGSLKTLGDKQCPLDGFDLLYWQGIGGK 669
Query: 479 DGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGV 538
+S+ +CP+C SNPPFEG+++ A + + TC L S G+
Sbjct: 670 LARSYAICPFCASNPPFEGMKSTTEMAAITAPIPAARSR----------TC--ELHSSGL 717
Query: 539 CAC--PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVD 596
C C P C G L LDP S KWR CN C ++ +GA ++ + C EC + +
Sbjct: 718 CGCTAPGCEGVLCLDPQSTGKWRFACNRCPAVITAYEGAKKMKLKESECEECGAREV--- 774
Query: 597 FNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
A L+D S GC+ C V + H
Sbjct: 775 ----AVTLKDESKFA-GCLFCAPEAKDQVNLNH 802
>C5LF56_PERM5 (tr|C5LF56) DNA topoisomerase OS=Perkinsus marinus (strain ATCC
50983 / TXsc) GN=Pmar_PMAR019675 PE=3 SV=1
Length = 813
Score = 484 bits (1247), Expect = e-134, Method: Compositional matrix adjust.
Identities = 261/647 (40%), Positives = 368/647 (56%), Gaps = 103/647 (15%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--GYEIQLEWQRSKLF 64
L + SYGPCQTPTL FCV+R+ I TF+PE +++++ + S + LEW R +LF
Sbjct: 203 LDSSLVSYGPCQTPTLWFCVRRHNDIQTFQPETYYTIDVKLEGSQLASPLWLEWSRGQLF 262
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D+ AT F+ ++ VT++SEK+E +SRP +NTV +LK+AS LG GP AMQ+A
Sbjct: 263 DLQAATTFKSMIDAYQWATVTDVSEKEERRSRPGAMNTVLMLKLASQQLGMGPQQAMQVA 322
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLY G+I+YPRTE+T YPP+FD R A+S Q+ NP WG + LLT G +P+ G D G
Sbjct: 323 ERLYLSGYITYPRTETTKYPPAFDLREAVSFQSRNPYWGEFATELLTTGLNRPKEGYDAG 382
Query: 185 DHPPITPMRPAAE-DMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTG 243
DHPPITP+R A E D +D+W+L+ + +HF+ ++ DCK+ R KV F IG E F G
Sbjct: 383 DHPPITPVRSATEGDFGSSDSWRLFDMLTRHFLASLGHDCKFTRTKVHFVIGDEKFSVGG 442
Query: 244 QHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
+ + + GFT + + D +P G+K++++ + T PP YL+ES+L+ LMEK
Sbjct: 443 RRMKSPGFTRVQYTGEMQDIYVPPLKIGEKLQIASKSISSAKTKPPPYLSESDLLGLMEK 502
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
NGIGTDAS+ HINNICE P + +
Sbjct: 503 NGIGTDASMATHINNICE----------------------------------PHALTIFQ 528
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCG 423
Q+ V HV + MD LFE+ F++L +G+++S+CG
Sbjct: 529 QKFMYF----------VSHV---------------DLMDHLFESTFTSLAATGKLMSRCG 563
Query: 424 KCLRYMKYISAQPSRLYCGICEEVYYLPQKG-TIKLYKELSCPLDNFELLLCS----MGP 478
KC YM I +P RL+C C+E Y LPQ G ++KLYKEL+CPLDNF+L++ S G
Sbjct: 564 KCRTYMNLIDKKPVRLFCRHCDETYALPQTGSSVKLYKELTCPLDNFQLVMISYPATAGG 623
Query: 479 DGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQG- 537
K +PLCP CY++PPF +K +S C C HPTC ++L S G
Sbjct: 624 GRKQYPLCPMCYNDPPFP-------ESKPKSS----------CWECLHPTCKHALASVGV 666
Query: 538 ---------------VCACPE--CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQG-AHRIS 579
VC CP+ CSGTL LD S PKW+L CN CN + L Q AH+I+
Sbjct: 667 RIIIICKFCYGKSRQVCGCPQDSCSGTLCLDAESKPKWKLDCNTCNYQLRLFQDKAHKIT 726
Query: 580 TTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVE 626
TK++C C S +++V+F+K + L +G+ GC++CD+ L+S VE
Sbjct: 727 VTKDKCENCGSKLLDVEFSKGKSSLSNGAESVVGCLVCDDALNSQVE 773
>G1QHD0_NOMLE (tr|G1QHD0) DNA topoisomerase OS=Nomascus leucogenys GN=TOP3B PE=3
SV=2
Length = 590
Score = 481 bits (1237), Expect = e-133, Method: Compositional matrix adjust.
Identities = 227/428 (53%), Positives = 303/428 (70%), Gaps = 3/428 (0%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFD 65
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W + + + L+W R ++FD
Sbjct: 163 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFD 222
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+A MF + + +V S K++ K RP+ LNTV +L+VASS+LG GP AMQ AE
Sbjct: 223 REIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAE 282
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLYTQG+ISYPRTE+T YP +FD +G+L QAN+P W + V+ LL G +PR G D GD
Sbjct: 283 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGD 342
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITPM+ A E LG DAW+L +YI +HFI TVS DCKY + + F IG E F C+G+
Sbjct: 343 HPPITPMKSATEAELGGDAWRL-EYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKT 401
Query: 246 VITKGFTAIMPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
V++ GFT IMPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+
Sbjct: 402 VLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKH 461
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDASIPVHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+
Sbjct: 462 GIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK 521
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGK 424
Q+ LIA+G+ D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGK
Sbjct: 522 QLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGK 581
Query: 425 CLRYMKYI 432
C R+MKYI
Sbjct: 582 CHRFMKYI 589
>B7FQA8_PHATC (tr|B7FQA8) DNA topoisomerase (Fragment) OS=Phaeodactylum
tricornutum (strain CCAP 1055/1) GN=PHATRDRAFT_8810 PE=3
SV=1
Length = 868
Score = 474 bits (1221), Expect = e-131, Method: Compositional matrix adjust.
Identities = 259/637 (40%), Positives = 359/637 (56%), Gaps = 15/637 (2%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L + SYGPCQTPTLGFCVQRY+ I TFKPE +W + ++ G ++ W + F+
Sbjct: 212 LNSAVLSYGPCQTPTLGFCVQRYIDIQTFKPEPYWVLELAVMKRGRSLRALWGSGRSFNK 271
Query: 67 N-VATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
N V + + + +VT + K + + RP+ LNTV LLK S ALG GPH +Q AE
Sbjct: 272 NKVEKLLLEALESGPFAKVTSVVAKDKKQGRPIPLNTVALLKACSKALGIGPHATLQTAE 331
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
RLY G++SYPRTES+AYP SFD G L Q+++ WG+YV LL G K R G D+GD
Sbjct: 332 RLYLSGYLSYPRTESSAYPKSFDIYGTLQQQSSDVRWGSYVRELLREGPNKSRGGIDMGD 391
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIG--GES--FHC 241
HPPITP R L D ++Y + +HFI +VS D + +++F+I GE F
Sbjct: 392 HPPITPCRATRAGELSGDMARVYDLVVRHFIASVSQDAVWRSTQIDFAIEALGEKGVFTL 451
Query: 242 TGQHVITKGFTAIMPWLAINDKNIP-SFIKGQKIEVSKVELYEGTTTPPDYLTESELISL 300
G+ ++ GF A++ ++NI S + G + + + + E TTPP YLTESELISL
Sbjct: 452 RGKEPVSPGFLAVLLHTEYGEENIEVSVVPGTTVR-ANLGIKEKMTTPPTYLTESELISL 510
Query: 301 MEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRS 360
MEKNGIGTDASI HI N+ +RNYV +++GR+LVP+ LGI L +GY ID L LP +RS
Sbjct: 511 MEKNGIGTDASISTHIENVQKRNYVALESGRRLVPSKLGIVLAQGYHQIDSSLVLPRVRS 570
Query: 361 FIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILS 420
IE + IAKG + VVQ I F+ KF FV I MD LF FS L D G+ +
Sbjct: 571 DIEDECNKIAKGLLSKDIVVQKAIDLFRNKFDSFVNNISKMDVLFSTSFSKLEDVGKPFT 630
Query: 421 KCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLD--NFELLLCSMGP 478
+CG RY+++I P RLY E VY LP G +K + C ++ NFEL L S+G
Sbjct: 631 RCGLTRRYLQFIEGPPPRLYNKWTETVYPLPSGGIVKQWTGRVCSVENCNFELCLFSVGN 690
Query: 479 DGKSFPLCPYCYSNPPF-----EGIEALINTAKTSTSGKIGKGAGMPCIL-CPHPTCPNS 532
++FPLCP C+++ + E + +T +I AG +L CP P S
Sbjct: 691 PQRTFPLCPRCFNDSKWSLDADELPQDPTDTEDEQKEKQITSIAGKRLVLECPLPDEHPS 750
Query: 533 LVSQGVCACPECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSI 592
+ V PE G L+LDP PKWRL +V++ +G +I+ ++ +
Sbjct: 751 IEELTVSTDPESDGVLILDPHMGPKWRLVSTRDPIIVYMPKGIEKITVLNKKDEALGVHL 810
Query: 593 IEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
++VDF +P DG + C DE+L + V + H
Sbjct: 811 MQVDFKAGDSPFPDGELKYTSCFPEDEVLKARVRIYH 847
>A7AST5_BABBO (tr|A7AST5) DNA topoisomerase OS=Babesia bovis GN=BBOV_II000360
PE=3 SV=1
Length = 878
Score = 466 bits (1200), Expect = e-128, Method: Compositional matrix adjust.
Identities = 262/648 (40%), Positives = 363/648 (56%), Gaps = 67/648 (10%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL FCV RY I F+ E ++ + I + G I W R ++FD +VA +F
Sbjct: 227 SYGPCQTPTLFFCVDRYNAIARFQEEPYYKLICDISYEGQYIPFTWNRGRIFDKSVARIF 286
Query: 73 QKLV-------------AEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHM 119
Q+LV A G+L T+I K+ S P LNTV +LK ASS G GPH
Sbjct: 287 QQLVRCEKYYNILQLMGANKGVL--TDIVTKRSINSSPKALNTVTMLKEASSRFGMGPHK 344
Query: 120 AMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNG-YLKPR 178
MQ AE LY G+ISYPRTE+ YP SFD+ L P + N V+ L+ +G L P+
Sbjct: 345 TMQTAEHLYLNGYISYPRTETDCYPTSFDWAELLKKLHTVPEYTNLVDLLMQSGNTLGPQ 404
Query: 179 LGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGES 238
G DVGDHPPI P+R ++ L D WKLY I +HF+ +V+ C + +G E+
Sbjct: 405 GGHDVGDHPPIIPVRCVSQGTLTGDDWKLYDLIVRHFLASVAGPCTTETTTYDLDVGSET 464
Query: 239 FHCTGQHVITKGFTAIMP----WLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTE 294
F + V+ +G+TA++P +++I K KG+ +V+K + EGTT+PP L+E
Sbjct: 465 FQFSNTRVVRQGYTALLPKSQNYVSIALK----LTKGEGCDVAKFRVEEGTTSPPPLLSE 520
Query: 295 SELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLC 354
S+L+ ME GIGTDAS+ HI+NI RNYV++ R++ PT LG LV GY +DP+L
Sbjct: 521 SDLLDHMESKGIGTDASMATHIHNIFTRNYVRLLGNRRIEPTKLGKALVDGYMQVDPELV 580
Query: 355 LPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVD 414
LP +R IE LIA G+ D V+ HV + F+ KF +++ KI++++ FE QF+ + D
Sbjct: 581 LPSVRGAIEGYCNLIADGKADCESVIDHVCRMFRMKFEHYITKIDSINTFFETQFTPIED 640
Query: 415 SGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLC 474
G +S+CG C RYM Y++ P RL+C C + Y LP+ GTIKLYK + CPLDNFELL
Sbjct: 641 FGVPMSRCGTCNRYMLYLNRAPVRLFCKKCSQEYPLPRGGTIKLYKGIKCPLDNFELL-- 698
Query: 475 SMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLV 534
++F LCP CY++PPFE I GM CI C HPTC NS
Sbjct: 699 QFQSRLRAFSLCPMCYNDPPFESI----------------GNKGMGCIDCAHPTCANSAD 742
Query: 535 SQGVCACP-ECSGTLVLDPVS-APKWRLCCNMCNCLV------------FLAQGAHRIST 580
+ + CP +C G L+LD ++ AP W+ C+ C+ + L RI
Sbjct: 743 ALTLTRCPGDCDGMLILDIINGAPNWKFFCSSCSYKLQFSDITKSRFDRLLLDYHERIEV 802
Query: 581 ---TKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLV 625
T + C C+S + EV L+DG + GC+ C+E L L+
Sbjct: 803 AIITGKECDSCESQLTEV-------ILKDGRKIE-GCVFCNESLKQLL 842
>H9IIY3_ATTCE (tr|H9IIY3) DNA topoisomerase OS=Atta cephalotes PE=3 SV=1
Length = 636
Score = 457 bits (1176), Expect = e-126, Method: Compositional matrix adjust.
Identities = 222/421 (52%), Positives = 284/421 (67%), Gaps = 12/421 (2%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVH-SGYEIQLEWQRSKLFDINVAT 70
SYGPCQTPTLGFCVQR+ +I TFKP+ +W + + G +I L W R + FD VA+
Sbjct: 216 ISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTVKSPDGQDIILNWNRVRSFDKEVAS 275
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MF V E V + ++ KSRP+ LNTV L++VASS LG GP AMQ+AERLYTQ
Sbjct: 276 MFLSHVKEYDQATVVSVQSTEKCKSRPIALNTVELMRVASSGLGMGPQHAMQIAERLYTQ 335
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTE+T+YP +FD L Q N+ WG V ++ G +P+ G D GDHPPIT
Sbjct: 336 GYISYPRTETTSYPENFDLLSTLKQQQNSSEWGEEVRKIIAAGINRPKKGHDAGDHPPIT 395
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PM+ A + L D W+LY YI +HFI T++ DC+Y V+F IG E F TG +++ G
Sbjct: 396 PMKHATRNELDGDLWRLYDYITRHFIATLARDCRYLSTTVKFEIGMEIFTATGHSLLSPG 455
Query: 251 FTAIMPWLAI-NDKNIPSFIKGQKIEVSK----------VELYEGTTTPPDYLTESELIS 299
+T+I+ W A+ N+ +P FI + + + + +L E T PPDYLTE+ELIS
Sbjct: 456 YTSILTWQALGNNDTLPKFISDENVNIQEPHIIQTEKYYAKLVECYTQPPDYLTEAELIS 515
Query: 300 LMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIR 359
LMEK+GIGTDASIPVHINNIC RNYV V AGRKL+PT+LGI LV GYQ IDP+L LP +R
Sbjct: 516 LMEKHGIGTDASIPVHINNICIRNYVTVAAGRKLIPTSLGIVLVHGYQKIDPELVLPTMR 575
Query: 360 SFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRIL 419
S +E+Q+ LIA G+ D H V+QH ++ FKQKF YFV+ IEAMD LFE FS L SG+
Sbjct: 576 SAVEEQLNLIALGRADFHAVLQHTVEIFKQKFHYFVQSIEAMDQLFEVSFSPLSASGKAH 635
Query: 420 S 420
S
Sbjct: 636 S 636
>M0V3B6_HORVD (tr|M0V3B6) Uncharacterized protein OS=Hordeum vulgare var.
distichum PE=3 SV=1
Length = 291
Score = 444 bits (1141), Expect = e-122, Method: Compositional matrix adjust.
Identities = 207/291 (71%), Positives = 236/291 (81%)
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
MFQK+VA DG L++T+IS K+E K+RP GLNTVNLLKVASSALG GP AM +AERLY Q
Sbjct: 1 MFQKMVASDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHMAERLYIQ 60
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTESTAYP SFDFR LS A+NP W N V L+ G++KPR G DVGDHPPIT
Sbjct: 61 GYISYPRTESTAYPASFDFRSVLSTLAHNPLWSNNVRTLMDAGFVKPRQGHDVGDHPPIT 120
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
PMR A E+ L DAW+LYQYICQHFIGTVS DC+Y R VEF+ GGE F C G V +KG
Sbjct: 121 PMRLAPEEALETDAWRLYQYICQHFIGTVSHDCRYTRTAVEFTSGGEIFRCVGHRVTSKG 180
Query: 251 FTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
FT+IMPWLA+ + N+P+F KG I + KV++YEG+TT PDYL+ESELISLMEKNGIGTDA
Sbjct: 181 FTSIMPWLAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISLMEKNGIGTDA 240
Query: 311 SIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSF 361
SIPVHINNI ERNYVQV GR+LVPT LG TL+RGYQ ID DLCLPDIRSF
Sbjct: 241 SIPVHINNISERNYVQVNTGRRLVPTALGTTLIRGYQCIDADLCLPDIRSF 291
>E3X5N1_ANODA (tr|E3X5N1) Uncharacterized protein OS=Anopheles darlingi
GN=AND_14242 PE=3 SV=1
Length = 752
Score = 441 bits (1134), Expect = e-121, Method: Compositional matrix adjust.
Identities = 250/626 (39%), Positives = 334/626 (53%), Gaps = 126/626 (20%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGFCVQR+ +I TFKPE FW V V E++L+WQR ++FD
Sbjct: 205 LDASLISYGPCQTPTLGFCVQRHDEIQTFKPETFWYVQ-VTVGENPELKLDWQRVRVFDK 263
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+A ++ + ++ E +E L V +L+
Sbjct: 264 EIACIY-----------LNKVKEHKE------ALGVVRMLQ------------------- 287
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDH 186
PS +F A A + T P+ G D GDH
Sbjct: 288 ------------------PSNEFGEEAKAIARDMT--------------SPKKGNDAGDH 315
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPITPMR A + L +D W++Y YIC+HF+GTVS D KY +F IGGE F T +
Sbjct: 316 PPITPMRLATRNELESDCWRIYDYICRHFLGTVSRDLKYRSHTTKFRIGGELFTATTSVL 375
Query: 247 ITKGFTAIMPWLAINDKNI-PSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
+ GFT +M W + + F +K++++ + L E T PPDYLTESELISLMEK+G
Sbjct: 376 LDPGFTKVMTWQSFAKNELGHQFTANEKVKINDIRLVESQTGPPDYLTESELISLMEKHG 435
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIP IDP+L LP +RS +EQQ
Sbjct: 436 IGTDASIP-----------------------------------IDPELVLPTMRSAVEQQ 460
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ LI++G D V++H ++ F+ KF YFV+ I MD LFEA FS+L SG+ LS+CGKC
Sbjct: 461 LNLISQGSADFRLVLKHAVEIFRLKFLYFVQNISNMDMLFEATFSSLCSSGKSLSRCGKC 520
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPL 485
RYMKYI +P RL+C C+E Y LP KG ++LY+E CPLD+FEL+ + G GK+FPL
Sbjct: 521 RRYMKYIQTKPQRLHCSTCDETYQLPVKGIVRLYREYKCPLDDFELVASTNGAKGKAFPL 580
Query: 486 CPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS 545
CPYCY++PPF ++ K +G C CPHPTC +SL GV +C EC
Sbjct: 581 CPYCYNHPPFRDMQ---------------KSSG--CNSCPHPTCAHSLSLLGVSSCFECD 623
Query: 546 -GTLVLDPVSAPK-WRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATP 603
G LVLD APK WRL CN+C+ ++ A ++ T ++ C EC + + + ++ TP
Sbjct: 624 RGVLVLDCTMAPKTWRLVCNVCDVIINCFDDATKV-TVEDSCEECGAQQVTALYKQEKTP 682
Query: 604 LEDGSTLHRGCILCDELLHSLVEMKH 629
DG T +GCI C LVE KH
Sbjct: 683 FADGVTEKKGCIFCFADFVPLVE-KH 707
>M1BDR0_SOLTU (tr|M1BDR0) Uncharacterized protein OS=Solanum tuberosum
GN=PGSC0003DMG402016626 PE=4 SV=1
Length = 290
Score = 436 bits (1122), Expect = e-119, Method: Compositional matrix adjust.
Identities = 209/292 (71%), Positives = 237/292 (81%), Gaps = 4/292 (1%)
Query: 379 VVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSR 438
VVQHV++QF++KF YFVK+I+ MDALFEAQFS L DSGR+LSKCGKCLRYMKYIS QP+R
Sbjct: 2 VVQHVLEQFRRKFSYFVKQIDNMDALFEAQFSPLSDSGRLLSKCGKCLRYMKYISTQPAR 61
Query: 439 LYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCPYCYSNPPFEG 497
LYCG CEEVYY+PQKGT+KLYKEL+CPLDNFELLLCSM GP+GKSFPLCPYC++ PPFEG
Sbjct: 62 LYCGTCEEVYYVPQKGTVKLYKELTCPLDNFELLLCSMPGPEGKSFPLCPYCFNCPPFEG 121
Query: 498 IEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGTLVLDPVSAPK 557
I+ KT S K+GKG GMPC LCPH TCP+S+++QGVCACPECSGTLVLDPVSAPK
Sbjct: 122 IDTFFGAPKTGDSTKLGKGVGMPCFLCPHTTCPHSVIAQGVCACPECSGTLVLDPVSAPK 181
Query: 558 WRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILC 617
WRL CNMCNCLV L +GAHRISTT+++CPECDS+IIEVDFNKK TPL+DG+TLH+GCILC
Sbjct: 182 WRLYCNMCNCLVSLPEGAHRISTTQDKCPECDSTIIEVDFNKKTTPLKDGATLHKGCILC 241
Query: 618 DELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVDPKMSFRDF 669
DELLHSLVEMKH DPKMSFRDF
Sbjct: 242 DELLHSLVEMKHGRSFSRHGRRGRGRGRGRGRGRGSTKQQ---DPKMSFRDF 290
>I1G5R1_AMPQE (tr|I1G5R1) DNA topoisomerase OS=Amphimedon queenslandica PE=3 SV=1
Length = 661
Score = 434 bits (1116), Expect = e-119, Method: Compositional matrix adjust.
Identities = 235/588 (39%), Positives = 322/588 (54%), Gaps = 97/588 (16%)
Query: 18 QTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE-IQLEWQRSKLFDINVATMFQKLV 76
QTPTLGFCV+R+ +I FKPEK+W ++ + HS + L+W + ++FD V +F ++
Sbjct: 165 QTPTLGFCVERHDEIQHFKPEKYWKLDCSVSHSSSNPLSLQWDKERIFDHEVIKLFHLML 224
Query: 77 AEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYP 136
+ V +SEK +K+ P+ L+TV +L+ SS L P AM +AERLYT+G+ISYP
Sbjct: 225 THHKIASVESVSEKSRSKAPPLPLHTVEMLRACSSRLHISPKQAMDIAERLYTEGYISYP 284
Query: 137 RTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAA 196
RTE+T YP FDF+ +S N + + LLT G P +G DVGDHPPITP+R A
Sbjct: 285 RTETTKYPAGFDFKSIVSDLNKNEHFKEFTSQLLTGGIRPPSVGKDVGDHPPITPLRNAP 344
Query: 197 EDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMP 256
+ + + WK+Y+ I HF+ T+ PDCKY + V FS+GGESF G +I GFT I
Sbjct: 345 REAVSDTQWKVYEMITCHFLATLFPDCKYKQTDVVFSLGGESFSWAGHTLIDPGFTLINT 404
Query: 257 WLAIND--KNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPV 314
W AI + F KGQK ++ ++ + E TTPP YLTESELISLMEK+ IGT
Sbjct: 405 WQAIGSVPQTTAQFCKGQKWDIVQLGVSEHMTTPPGYLTESELISLMEKHAIGT------ 458
Query: 315 HINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQI 374
IDP+L P +RS IE+Q+ IA G+
Sbjct: 459 ----------------------------------IDPELVKPTMRSEIEKQLNEIALGKA 484
Query: 375 DHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISA 434
D+ +V+ H + F++KF YF + M+ LFEA FS++ + ++LS+CGKCLRYM YI
Sbjct: 485 DYDQVLSHTLDIFRRKFSYFRDNVSGMNELFEATFSSVASTAKLLSRCGKCLRYMTYIPV 544
Query: 435 QPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPP 494
+P RL+C C+E Y LPQ G+IKLYKE+ CPLD FE+++ S GP GK+
Sbjct: 545 KPQRLHCKHCDETYSLPQNGSIKLYKEIKCPLDGFEIVIFS-GPRGKA------------ 591
Query: 495 FEGIEALINTAKTSTSGKIGKGAGMPCILCPH-PTCPNSLVSQGVCACPECSGTLVLDPV 553
M + H P+C N GTL+LDP
Sbjct: 592 ------------------------MNQLSIDHCPSCDN--------------GTLLLDPS 613
Query: 554 SAPKWRLCCNMCNCLVFLA--QGAHRISTTKERCPECDSSIIEVDFNK 599
S PKW++ CN C V L +G H + T CPEC + + VDF K
Sbjct: 614 SGPKWKMYCNSLACPVVLHCFEGVHNVEKTINECPECGAYHVLVDFKK 661
>I7M423_TETTS (tr|I7M423) DNA topoisomerase OS=Tetrahymena thermophila (strain
SB210) GN=TTHERM_00465030 PE=3 SV=1
Length = 1386
Score = 429 bits (1104), Expect = e-117, Method: Compositional matrix adjust.
Identities = 239/638 (37%), Positives = 343/638 (53%), Gaps = 54/638 (8%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE-IQLEWQRSKLFDINVATM 71
++GPCQTPTL FCVQR +I F + F+ + P I E I LEW + + +D A
Sbjct: 451 TFGPCQTPTLSFCVQRDDEIKDFISKPFYRIIPKISLVPNELINLEWTKERTYDQQEALD 510
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
++ + G V ++ K+ K +PV LNTVN LK+AS G GP AMQ+AE+LY G
Sbjct: 511 VKQELESIGQTSVVKVDNKETQKIKPVALNTVNFLKMASKQYGLGPQNAMQVAEKLYLGG 570
Query: 132 FISYPRTESTAYPPSFDFRGALSA---QANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPP 188
FI+YPRTEST YP FDF L A N Y + L NG K RLG DVGDHPP
Sbjct: 571 FITYPRTESTKYPDKFDFNSVLHAVCQYHQNQNISIYAQKLQQNGIHKSRLGKDVGDHPP 630
Query: 189 ITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEF---------------- 232
ITP L D +Y+ +C+HF+ TVS DC+ ++KV F
Sbjct: 631 ITPTNKIMRQQLSRDEQNIYELVCRHFLATVSSDCRLYKKKVNFYCKIYFYQTKKNNKVL 690
Query: 233 -SIGGESFHCTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDY 291
G ++F G VI KG+ +PW I + IP+F +G +I + V+++ G T PPD+
Sbjct: 691 FQTGNQTFSLIGTAVIDKGYLEALPWQKIYENEIPNFSEGDQIYLHSVDIHSGKTQPPDH 750
Query: 292 LTESELISLMEKNGIGTDASIPVHINNICERNYVQVQA-GRKLVPTTLGITLVRGYQSID 350
LTES+LISLME+NGIGTDAS+ HI NIC+R YVQV R+LVPT LG +L+ Y ID
Sbjct: 751 LTESDLISLMEQNGIGTDASMAQHIQNICDREYVQVVGQARRLVPTELGSSLIHAYAEID 810
Query: 351 PDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFE---A 407
P+L P++RS IE+ + LI++G++D +V+Q VI+ FK K+ YFV K+ +D F+
Sbjct: 811 PELVAPNLRSSIERSVDLISQGELDKDQVLQSVIELFKNKYLYFVSKVGVLDKYFDPIYQ 870
Query: 408 QFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLD 467
T + + +KCG+C MK I + +++C C+ +Y LP+ + E CP+D
Sbjct: 871 SIETTISQAQYFTKCGRCKCNMK-ILDKIGKIFCERCKFMYGLPRDSKYSIAGECFCPID 929
Query: 468 NFELLLCSMGPDG--KSFPLCPYCYSN-PPFEGIEALINTAKTSTSGKIGKGAGMPCILC 524
F+L+L G K F +CP C+ P E + +TS C LC
Sbjct: 930 GFQLVLIESTVKGNTKRFTICPLCFQKTPELENYSSEEKYQRTS------------CNLC 977
Query: 525 PHPTCPNSLVSQGVCACPECS----GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRIST 580
+ +C S+V+ + CP C G LVLD + + CN C + + I
Sbjct: 978 SNRSCQFSMVNNEIGPCPHCKYEKGGRLVLDWPDNNNYTMTCNACMYQYLIVKNGKLIR- 1036
Query: 581 TKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCD 618
++ +C C+ ++++ + + L GC+ CD
Sbjct: 1037 SQMKCANCNCFQVKIETSDGFSAL--------GCLFCD 1066
>G7YI59_CLOSI (tr|G7YI59) DNA topoisomerase III OS=Clonorchis sinensis
GN=CLF_108504 PE=3 SV=1
Length = 887
Score = 429 bits (1104), Expect = e-117, Method: Compositional matrix adjust.
Identities = 211/414 (50%), Positives = 279/414 (67%), Gaps = 5/414 (1%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYI-VHSGYEIQLEWQRSKLFDINVATM 71
S+GPCQTPTLGFCV+R+ +I +FKPE FW + + V G + L W R +LFD A +
Sbjct: 106 SFGPCQTPTLGFCVKRHDRIQSFKPESFWRIKASLSVKGGATMDLVWTRDRLFDKEAAMV 165
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
F V EV +++ K++ K RP GLNTV +L+VAS+ LG GPH AM +AERLYT G
Sbjct: 166 FLTKVKSCCTAEVMQVTTKEKVKPRPQGLNTVEMLRVASACLGIGPHAAMAVAERLYTSG 225
Query: 132 FISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITP 191
+I+YPRTE+T YP +FD RG + QA +P WG+ LL +G PR G D GDHPPI P
Sbjct: 226 YINYPRTETTTYPSTFDLRGLVQQQAKHPQWGDVARDLLASGLTPPRKGHDAGDHPPIAP 285
Query: 192 MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIG-GESFHCTGQHVITKG 250
MR A LG+DA +LY++I QHF+ TV PDC+Y +V SIG GE F TG V+ G
Sbjct: 286 MRMATPGELGHDAARLYEFIAQHFLATVMPDCRYESTQVTLSIGDGELFTLTGIRVLEPG 345
Query: 251 FTAIMPWLAINDKNIPS--FIKGQKIEVS-KVELYEGTTTPPDYLTESELISLMEKNGIG 307
FT I+ A+ D+ +P ++G KI ++ + L EG T PPDYLTE+ELI+ ME++GIG
Sbjct: 346 FTRILTRQALTDQTLPDEILVRGAKIPLAGEPTLVEGQTGPPDYLTEAELITAMERHGIG 405
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDASIP HI NI +R YVQ+ GR+L PT LGI LV GYQ+IDP+L LP +R +E+Q+
Sbjct: 406 TDASIPTHIENIVQRAYVQLLPGRRLQPTPLGIVLVHGYQAIDPELVLPHMRRAVEEQLN 465
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSK 421
IA G+ +V+Q V+ F K+ YF++ I AMD LFE FS+L +SG+ LS+
Sbjct: 466 HIANGRAQFEQVLQFVVAIFAAKYRYFIEHILAMDQLFEVSFSSLSESGKPLSR 519
>H2YRK7_CIOSA (tr|H2YRK7) DNA topoisomerase OS=Ciona savignyi PE=3 SV=1
Length = 601
Score = 411 bits (1056), Expect = e-112, Method: Compositional matrix adjust.
Identities = 202/401 (50%), Positives = 264/401 (65%), Gaps = 29/401 (7%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV--HSGYEIQLEWQR---- 60
L + SYGPCQTPTLGFCV R+ +I +FKPE FW ++ + ++G I L+W R
Sbjct: 198 LDSSLISYGPCQTPTLGFCVDRHDKIQSFKPEPFWVIDVKVKCPNNGPTISLDWSRFAFF 257
Query: 61 ---------------------SKLFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVG 99
++FD +VA M+ L+ E + I++K++TK RP
Sbjct: 258 NFSNSISWIHSHTILLLAFLRGRIFDQSVAKMYLSLIKESKKAIIKNITKKEKTKQRPQA 317
Query: 100 LNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANN 159
LNTV +L+VAS++L GP AMQ AE LYT+GFISYPRTE+T YP +FDFR ALS Q +
Sbjct: 318 LNTVEMLRVASASLNIGPQQAMQAAEHLYTRGFISYPRTETTHYPENFDFRSALSTQTRS 377
Query: 160 PTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDML-GNDAWKLYQYICQHFIGT 218
+WG YV LL+ G+ KPR G+D GDHPPITPM A E + G+D+W+LY+YI +HFI T
Sbjct: 378 RSWGAYVSSLLSTGFTKPRKGSDAGDHPPITPMLCATEQEIGGHDSWRLYEYIVRHFIAT 437
Query: 219 VSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAIND-KNIPSFIKGQKIEVS 277
+SPDC Y V+F I E+F CTG + GFT +MPW +IND + +P+ G + V
Sbjct: 438 LSPDCTYMHTVVQFKIADETFTCTGSLPLKAGFTEVMPWQSINDHQTLPTLQTGDECSVE 497
Query: 278 KVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTT 337
+ EL + T+PPDYLTESELI+LMEK+GIGTDASIP HINNI +RNYV V +GRKL PT
Sbjct: 498 RAELLDRKTSPPDYLTESELITLMEKHGIGTDASIPTHINNIGQRNYVTVISGRKLQPTN 557
Query: 338 LGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHR 378
LGI LV GY ID DL P +RS +E+Q+ LIA+G + +
Sbjct: 558 LGIMLVHGYNKIDADLVQPTMRSAVEKQLNLIAQGNKNQKK 598
>Q4R3L0_MACFA (tr|Q4R3L0) Testis cDNA clone: QtsA-16130, similar to human
topoisomerase (DNA) III beta (TOP3B), OS=Macaca
fascicularis PE=2 SV=1
Length = 407
Score = 405 bits (1041), Expect = e-110, Method: Compositional matrix adjust.
Identities = 194/377 (51%), Positives = 259/377 (68%), Gaps = 19/377 (5%)
Query: 255 MPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIP 313
MPW ++ ++++P+ +G V +V++ E T+PPDYLTE+ELI+LMEK+GIGTDASIP
Sbjct: 1 MPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIP 60
Query: 314 VHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQ 373
VHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+Q+ LIA+G+
Sbjct: 61 VHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGK 120
Query: 374 IDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYIS 433
D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGKC R+MKYI
Sbjct: 121 ADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQ 180
Query: 434 AQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNP 493
A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+PLCPYCY++P
Sbjct: 181 AKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHP 240
Query: 494 PFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPEC-SGTLVLDP 552
PF ++ GM C C HP+C +SL G+ C EC SG LVLDP
Sbjct: 241 PFRDMK-----------------KGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDP 283
Query: 553 VSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHR 612
S PKW++ CN C+ + + AHR+ + + C C++++++VDFNK +PL T H
Sbjct: 284 TSGPKWKVACNKCSVVAHCFENAHRVRVSTDTCSVCEAALLDVDFNKAKSPLPGDETQHM 343
Query: 613 GCILCDELLHSLVEMKH 629
GC+ CD + LVE+KH
Sbjct: 344 GCVFCDPVFQELVELKH 360
>A0DGW1_PARTE (tr|A0DGW1) DNA topoisomerase OS=Paramecium tetraurelia
GN=GSPATT00002407001 PE=3 SV=1
Length = 949
Score = 403 bits (1035), Expect = e-109, Method: Compositional matrix adjust.
Identities = 230/595 (38%), Positives = 335/595 (56%), Gaps = 44/595 (7%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS-GYEIQLEWQRSKLFD----IN 67
++GPCQTPTLGFCV+R+ +I F P F+++ I+++ GY+ ++EW +++
Sbjct: 231 TFGPCQTPTLGFCVERHEEIVNFVPRAFYTIKLSILNNVGYKQEVEWLGQQIWKEPEAKQ 290
Query: 68 VATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERL 127
V QK D + + E Q++K RP G+NTV+LLK ASS LG GP AM +AERL
Sbjct: 291 VVQQLQKFKQGDVISQQVE----QKSKPRPEGINTVSLLKFASSYLGLGPQQAMHVAERL 346
Query: 128 YTQGFISYPRTESTAYPPSFDFRGALS--AQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
Y G+ISYPRTE+TAYP F ++ + +P + + L TNG+ P+ G DVGD
Sbjct: 347 YLNGYISYPRTETTAYPHEFPTPKIINNLQKYKDPLISEHSKYLKTNGHSNPKQGVDVGD 406
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITP ++ L + +Y+Y+ + F+ S DCKY ++F +G F ++
Sbjct: 407 HPPITPTENVPQNNLYGEEKTMYEYVVKMFLAAHSKDCKYENHTLKFFVGDHQFKFQSKY 466
Query: 246 VITKGFTAIMPWLAI--NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
++ GFT + WLAI N ++ F+ K+++ VE +G T+PPD+LTE+ELI+LM+K
Sbjct: 467 ILDPGFTKVATWLAITENKSDLTKFVTNNKVQIGFVEYQQGQTSPPDHLTETELITLMDK 526
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
IGTDAS+ HINNICER YV+V+ + RKL PT LG++LVRGY+ IDPDL P +RS I
Sbjct: 527 FKIGTDASMATHINNICERQYVKVEGSSRKLKPTDLGLSLVRGYKRIDPDLVAPQLRSSI 586
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFS-----TLVDSGR 417
E Q+ IAKG++ +V+Q VIQ F +K+ +F ++I + Q D
Sbjct: 587 ESQVDQIAKGKLKCQQVIQDVIQIFTKKYIHFRERINDFQLVQYHQQGINRQIKQSDEEI 646
Query: 418 ILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMG 477
ILS+CG C RY+ + + S + C C + Y L K Y CP D FELL C+
Sbjct: 647 ILSRCGDCNRYL--VQSNNSAI-CKQCIKTYPLLPDCKFKAYGAYRCPFDKFELLFCTSN 703
Query: 478 PDG-KSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQ 536
+ LCP C+S+ P L+ + + + C +CP+ C S S+
Sbjct: 704 KSPFNTTLLCPKCFSSSP------LVTSEQCT------------CNICPNVDCEKSKESR 745
Query: 537 GVCACPECS-GTLVLDPVSAPKWRLC--CNMCNCLVFLAQGAHRISTTKERCPEC 588
V C C G L+L+P + ++C CN C CL L ++ TK C EC
Sbjct: 746 MVGKCKSCKIGELILEPFISKGQQICLSCNECWCLYQLVPAVVQVDITKNACTEC 800
>Q24DD8_TETTS (tr|Q24DD8) DNA topoisomerase OS=Tetrahymena thermophila (strain
SB210) GN=TTHERM_01262890 PE=3 SV=1
Length = 1374
Score = 399 bits (1025), Expect = e-108, Method: Compositional matrix adjust.
Identities = 225/587 (38%), Positives = 330/587 (56%), Gaps = 28/587 (4%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNP-YIVHSGYEIQLEWQRSKLFDINVATM 71
S+GPCQTPTLGFCV+R +I FKP ++ + ++ G E+ + ++D +
Sbjct: 745 SFGPCQTPTLGFCVEREDEIKNFKPRLYFRIRATFVTEDGMEVVSYCDKGHIYDQGESNK 804
Query: 72 FQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQG 131
K V +++T++S TK RP GLNTV LLK+ASS L P M +AERLY G
Sbjct: 805 IFKDVLNQQHIQITQVSSDFGTKQRPEGLNTVQLLKIASSYLHMSPMETMHVAERLYLNG 864
Query: 132 FISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITP 191
+I+YPRTESTAYP +F FR L++ ++ +G + LL + Y +PR G D+GDHPPITP
Sbjct: 865 YITYPRTESTAYPKAFQFREILNSLQSDSDYGKFASNLLQD-YKQPRSGVDMGDHPPITP 923
Query: 192 MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGF 251
+ LG D KLY YI +HFI ++S DCKY + ++ SI +F G ++ KGF
Sbjct: 924 TTNYP-NSLGGDERKLYDYISKHFIASLSEDCKYKKITIQGSICNYNFIARGIQMVNKGF 982
Query: 252 TAIMPWLAINDKNIPSFI-KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDA 310
T + +++ + I S + +G++++V+ + + T+ P Y+TESELISLMEKN IGTDA
Sbjct: 983 TEVQDHISLGENTIASNLQQGKQLKVTSINQEQEYTSAPGYITESELISLMEKNSIGTDA 1042
Query: 311 SIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLI 369
S+ HI NI RNYVQ+ + R LVPT LG +LV GYQ IDP+L P IRS IE + I
Sbjct: 1043 SMATHIQNIVNRNYVQINGSNRSLVPTELGRSLVHGYQKIDPELVQPQIRSKIENMVDQI 1102
Query: 370 AKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYM 429
AKG V+ ++ F+ K+ FV+ I +D+LF QF ++S + SKCG C R+M
Sbjct: 1103 AKGNKQFADVINDSMRIFQAKYLTFVENILKIDSLF-GQFCNTLESAKPFSKCGVCNRFM 1161
Query: 430 KYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELL-LCSMGPDGKSFPLCPY 488
K I + ++ C C+ ++P G +L E CP D ++++ S+ SF +CP
Sbjct: 1162 KIIE-KAGKIICEKCDVSLFIPSNGKYRLAGEKKCPYDKYQVIFFTSLHTPNVSFEVCPK 1220
Query: 489 CYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS-GT 547
CY+ P +E+ + C +C + C S+ S+ + C C G
Sbjct: 1221 CYTESP--NMES----------------DQVTCSICTNEECKLSMNSRFLKECQICKMGD 1262
Query: 548 LVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKE-RCPECDSSII 593
+V++P A K CN C L + KE +C +C S +I
Sbjct: 1263 IVIEPQVAQKLAAMCNECWTQWSLPIQNKDLKVNKEKKCDKCQSQLI 1309
>I7IPQ5_BABMI (tr|I7IPQ5) DNA topoisomerase OS=Babesia microti strain RI
GN=BBM_I03410 PE=3 SV=1
Length = 810
Score = 390 bits (1001), Expect = e-105, Method: Compositional matrix adjust.
Identities = 232/620 (37%), Positives = 329/620 (53%), Gaps = 79/620 (12%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL FCV+R+ QI +F+P+ ++ V
Sbjct: 208 SYGPCQTPTLFFCVERFKQIKSFQPQTYYRV----------------------------- 238
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
++ + ++ + +T +RP LNTVNLLK+AS L GPH A+ +AE+LY G+
Sbjct: 239 -----KEEVFVLSAVYSSVKTIARPTALNTVNLLKMASQQLHLGPHHALSVAEKLYLSGY 293
Query: 133 ISYPRTESTAYPPSFDFRGALSA--QANNPT---WGNYVEGLLTNGYLKPRLGTDVGDHP 187
ISYPRTE+ YP +FD G L+ AN P G+ + + N R G D GDHP
Sbjct: 294 ISYPRTETMTYPKNFDTEGVLNMLRSANFPRDIFTGSKTDSIKFNLNQICR-GKDAGDHP 352
Query: 188 PITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVI 247
PITP+ L +D +Y I ++F+ ++S DCKY K F+ E+F T V+
Sbjct: 353 PITPVSVPNPSYLSSDELNIYLLIVRNFLESISVDCKYKEEKYSFTAASETFIYTCTKVV 412
Query: 248 TKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIG 307
GFT+I ++ + + + G + E+ TTPP L+ES+L+ LMEKNGIG
Sbjct: 413 EPGFTSISNKSSLTESSPITASAGDIYRLCGCEIRSAQTTPPSLLSESDLLELMEKNGIG 472
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDAS+ HINNIC R YV++ R+L PT LG +LV GY +DP+L LP +R IE
Sbjct: 473 TDASMATHINNICLRGYVKIVGNRRLEPTKLGQSLVYGYLQVDPELVLPTVRGNIESLCD 532
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLR 427
IA G+ V+ H +Q F+ KF YF I++M F F+ D G ++S+CG C R
Sbjct: 533 SIATGKATLETVINHSLQIFRVKFIYFTANIDSMVQAFMQNFTLAEDLGTLMSRCGVCNR 592
Query: 428 YMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCP 487
YM Y+++ RL C C+ VY LP GT++L+KE+ CPLDNFEL+ + GKS+ LCP
Sbjct: 593 YMVYVNSAFPRLVCKHCDSVYKLPIGGTVRLFKEIKCPLDNFELVQYQV-KGGKSYTLCP 651
Query: 488 YCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGT 547
CY++PPFE + M C CPHPTC N++ S V C EC G
Sbjct: 652 MCYNDPPFE---------------DFSNKSAMNCSKCPHPTCTNAIRSISVAVC-ECEGM 695
Query: 548 LVLDPVS-APKWRLCCNMCNCLVFLAQGAHRISTT---KERCPECDSSIIEVDFNKKATP 603
L D ++ KWR+ CN C+ + I T + C EC+ ++ +
Sbjct: 696 LYFDVINQGHKWRILCNNCSV-------QYNIETKIKLNDFCDECEGRMVLI-------- 740
Query: 604 LEDGSTLHRGCILCDELLHS 623
++ G GCI+C+ + S
Sbjct: 741 VDKGI---EGCIMCNSDVRS 757
>E3CU83_CAEBR (tr|E3CU83) DNA topoisomerase (Fragment) OS=Caenorhabditis briggsae
GN=CBG20786 PE=3 SV=2
Length = 591
Score = 387 bits (994), Expect = e-105, Method: Compositional matrix adjust.
Identities = 185/386 (47%), Positives = 252/386 (65%), Gaps = 4/386 (1%)
Query: 9 AVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINV 68
+ SYGPCQTPTLGFCV R+ QI FKPE +W + EWQR ++FD +
Sbjct: 207 STVISYGPCQTPTLGFCVTRHDQIVQFKPESYWVLKTTFSCDSQTFSPEWQRGRIFDAEI 266
Query: 69 ATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLY 128
A +F + + V ++S+K+ K RP LNTV L++VASS+LG P M +AE LY
Sbjct: 267 AKLFVDRIKKSHTGVVVDVSKKEARKERPCALNTVELMRVASSSLGLSPSTTMHVAESLY 326
Query: 129 TQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPP 188
TQG+ISYPRTE+TAYP +FD G L + + WG+ V +L G +P+ G D GDHPP
Sbjct: 327 TQGYISYPRTETTAYPANFDLNGTLKILSGDRKWGSVVSQVLAEGIKRPKSGVDKGDHPP 386
Query: 189 ITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVIT 248
ITPMR A L D ++Y+Y+ QHF+ T+ C Y V+ G E F G++V+
Sbjct: 387 ITPMR-ANTGGLSGDMARIYEYVSQHFVATLMKPCIYEVTTVKMMCGEEQFTIQGKNVVD 445
Query: 249 KGFTAIMPWLAINDK-NIPSFIK--GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
GFTAIMPWL + ++ ++P ++ G KIE+ ++ TTPP YLTE+ELI+LMEK+G
Sbjct: 446 PGFTAIMPWLGVEEECSVPKSLQQVGAKIELQDAQIQARETTPPGYLTEAELITLMEKHG 505
Query: 306 IGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
IGTDASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +R+ +E+Q
Sbjct: 506 IGTDASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQ 565
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKF 391
+ L+A G+ D+H V H ++ F+ KF
Sbjct: 566 LNLVASGKADYHDVKNHALKMFEMKF 591
>Q95R42_DROME (tr|Q95R42) SD10251p OS=Drosophila melanogaster GN=Top3beta PE=2
SV=1
Length = 444
Score = 384 bits (986), Expect = e-104, Method: Compositional matrix adjust.
Identities = 190/395 (48%), Positives = 257/395 (65%), Gaps = 21/395 (5%)
Query: 237 ESFHCTGQHVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTES 295
E+F CT +I GFT +M W A D+ P F++G ++ ++ V L E T PPDYLTES
Sbjct: 2 ETFSCTASVLIDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTES 61
Query: 296 ELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCL 355
ELI+LME++GIGTDASIPVHINNIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L L
Sbjct: 62 ELITLMEEHGIGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVL 121
Query: 356 PDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDS 415
P +R+ +E+ +TLIA+G + V++H I+ FK KF YFVK I++MDALFE FS L +S
Sbjct: 122 PTMRTEVERMLTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAES 181
Query: 416 GRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCS 475
G+ S+CGKC RYMKYI +P+RL+C C+E Y LP G +K+Y+E CPLD+F+LL S
Sbjct: 182 GKAHSRCGKCRRYMKYIQTKPARLHCSHCDETYALP-IGNVKVYREFKCPLDDFDLLAFS 240
Query: 476 MGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVS 535
G G+S+P CPYCY++PPF + L C C + CP+SL +
Sbjct: 241 TGVKGRSYPFCPYCYNHPPFSDMPHLGG-----------------CNTCTNANCPHSLNT 283
Query: 536 QGVCACPEC-SGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIE 594
G+ +C EC +G LVLD AP W+L CN C+ ++ +GA +I+ + +C EC + +
Sbjct: 284 LGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVN 343
Query: 595 VDFNKKATPLEDGSTLHRGCILCDELLHSLVEMKH 629
V + + +DGS GCI C LVE KH
Sbjct: 344 VVYKSDKSKFKDGSEEKSGCIFCSADFSHLVE-KH 377
>E5T3E6_TRISP (tr|E5T3E6) DNA topoisomerase domain protein (Fragment)
OS=Trichinella spiralis GN=Tsp_13761 PE=3 SV=1
Length = 549
Score = 382 bits (981), Expect = e-103, Method: Compositional matrix adjust.
Identities = 197/488 (40%), Positives = 275/488 (56%), Gaps = 33/488 (6%)
Query: 153 LSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAE-DMLGNDAWKLYQYI 211
L A + + + + +L G P+ G D GDHPPITP+ E +LY+Y+
Sbjct: 1 LGPLAKSGQFASVAQAILDRGVRMPKSGQDAGDHPPITPLGHVGEPKFTSTSEARLYEYV 60
Query: 212 CQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAI--NDKNIPSFI 269
HF+ T+ +C Y R ++ + GE F T I GFT + W + N+ ++P+ +
Sbjct: 61 VCHFLATLMGNCVYELRTIQLDLAGERFTLTSSRPIDPGFTEVFTWQQVTANENSLPATV 120
Query: 270 K-GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQ 328
G + V + + +G T+PPD+LTE+ELI+LME++GIGTDASIPVHINNIC+RNYV VQ
Sbjct: 121 NVGDRWNVVDLLMDQGQTSPPDHLTETELITLMERHGIGTDASIPVHINNICQRNYVTVQ 180
Query: 329 -AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQF 387
+ R+LVPT LG+ LV GY ID L ++RS IE Q+ LIA GQ + + +H++ F
Sbjct: 181 ESSRRLVPTQLGVILVHGYWKIDCQLVEAEMRSAIEHQLMLIADGQANPASMKEHILDIF 240
Query: 388 KQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEV 447
+KF YFV+ + MDALFE F TL DSG+ S+CG+C RYMK + RL+C C+
Sbjct: 241 TKKFHYFVENVALMDALFEDTFQTLADSGKPFSRCGRCRRYMKIVLQGKKRLFCATCQLT 300
Query: 448 YYLPQKGTIKL--YKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTA 505
Y LP+ TI + CPLD F+L+ C G +G LCPYCYSNPPFE +
Sbjct: 301 YPLPRGSTISFRPLNDAKCPLDGFDLIYCVNGGNGGDHALCPYCYSNPPFEDMR------ 354
Query: 506 KTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECS---------GTLVLDPVSAP 556
C C HPTCP S + V C C+ G+L+LDP SAP
Sbjct: 355 -----------PEQACNRCTHPTCPYSSRTLAVAICEYCARTAAKSAFRGSLLLDPGSAP 403
Query: 557 KWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCIL 616
KW+LCCN C V + +GA + T + CP+C+S ++ V + + P DG + + C+
Sbjct: 404 KWQLCCNQCKFKVRIFKGAKMVRVTDDHCPQCNSRLVHVIYTQADNPFTDGKSEKKRCVT 463
Query: 617 CDELLHSL 624
CD L
Sbjct: 464 CDGEFRKL 471
>H3G0S0_PRIPA (tr|H3G0S0) DNA topoisomerase OS=Pristionchus pacificus
GN=WBGene00117729 PE=3 SV=1
Length = 953
Score = 379 bits (974), Expect = e-102, Method: Compositional matrix adjust.
Identities = 188/447 (42%), Positives = 271/447 (60%), Gaps = 8/447 (1%)
Query: 4 FIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVN-PYIVHSGYEIQLEWQRSK 62
+ L A SYGPCQTPTL FCV R+ +I F+PE +W + + G ++ +W R +
Sbjct: 206 YAELDASTVSYGPCQTPTLAFCVNRHDEIVNFRPEPYWVIQTEFEARDGSSVKGDWARQR 265
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
+ D A M+ + + G+ V +I+ K+ + P LNTV L++ AS+ LG P M
Sbjct: 266 VHDPADAQMYLNRIRQAGVAAVFDINTKRSDRYPPHALNTVKLMRAASTQLGLSPATTMH 325
Query: 123 LAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTD 182
+AE LYTQG+ISYPRTE++ YP +FD RG LS Q N+ WG+ ++ G +PR G D
Sbjct: 326 IAESLYTQGYISYPRTETSTYPTNFDLRGTLSRQTNDRRWGDIASRVMQEGINRPRGGAD 385
Query: 183 VGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
GDHPPITPMR + G++A ++Y+Y+ +HFI T+ +C Y V+ + G E F
Sbjct: 386 KGDHPPITPMRSDGGALHGDNA-RVYEYVVRHFIATLMRNCVYEVTTVKMNCGEEEFSFQ 444
Query: 243 GQHVITKGFTAIMPWL-AINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLM 301
G+ +I GFT I+ A D +P +G ++ + E+ + T PP YLTESELIS+M
Sbjct: 445 GKQLIDPGFTLILSASGAEKDVWMPRVERGDQMRLKSAEVVDRQTIPPSYLTESELISMM 504
Query: 302 EKNGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRS 360
E++GIGTDASIPVHIN IC+RNYV V+ R+L+PT LG+ L+ GY ++DP+L LP IR+
Sbjct: 505 EQHGIGTDASIPVHINTICQRNYVTVETTSRRLIPTQLGVCLIHGYHAVDPELVLPTIRA 564
Query: 361 FIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILS 420
+E+Q+ +IA GQ D V H + F++KF YF + DALF A F T+ R +
Sbjct: 565 DLERQLDMIASGQADFMTVKNHAVDLFRRKFLYFKDNMPRFDALFAATFRTVSVEERQST 624
Query: 421 KCGKCLRYMKYISAQPSRLYCGICEEV 447
C KC + S P ++C C++
Sbjct: 625 VCPKC----RVNSKTPGHIHCQQCKDA 647
>K8F5K0_9CHLO (tr|K8F5K0) DNA topoisomerase OS=Bathycoccus prasinos
GN=Bathy05g03570 PE=3 SV=1
Length = 949
Score = 378 bits (971), Expect = e-102, Method: Compositional matrix adjust.
Identities = 236/668 (35%), Positives = 342/668 (51%), Gaps = 111/668 (16%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVN---PYIVH-------------------- 49
SYGPCQTPTLGFCV+R+L+I F PE FW + P +
Sbjct: 244 SYGPCQTPTLGFCVKRHLEIIRFVPESFWRLKLNLPTVAAASLKQSDDDVVIVDDDNGMA 303
Query: 50 ---SGYEI-QLEWQRSKLFDINVATMFQKLVAE-------DGLLEVTEISEKQETKSRPV 98
+ YEI + +W R ++FD + A + L ++ G L V I KQ +K P
Sbjct: 304 TKTTSYEIAEWKWHRERVFDESSAISLEALCSDFLKKKDKKGTL-VGTIRSKQ-SKRPPP 361
Query: 99 GLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQAN 158
G+NTV +LK S +G G H AMQ+AERLY GFISYPRTES+AYPP FDF+ +++Q +
Sbjct: 362 GMNTVEMLKTCSK-MGIGAHRAMQIAERLYLDGFISYPRTESSAYPPGFDFKSIVASQTS 420
Query: 159 NPTWGNYVEGLLT-NGYLKPRLGTDVGDHPPITPM-RPAAEDMLGNDAWKLYQYICQHFI 216
N WG+ + +L+ + KP G D GDHPPITP R + + + +++Y+ I +HF+
Sbjct: 421 NDEWGDVAKKILSFSSIRKPSGGQDAGDHPPITPAGRFGNRNSMNGEMFRVYELISRHFL 480
Query: 217 GTVSPDCKYARRKVEFSIG-GESFHCTGQHVITKGFTAIMPWLAINDKNIPSFI------ 269
T+ PD + E I E + G ++ G+T +P A K IP
Sbjct: 481 ATLLPDLVLENIESEIVIAESERWKAKGVKILDFGWTEALPRRAPKLKIIPDAYQLSDNE 540
Query: 270 ----KGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYV 325
K + ++V V + G T PP+YLTESELI MEKNGIGTDASIP HIN + R Y
Sbjct: 541 SKNNKSRDVDVISVTIERGETQPPNYLTESELIGTMEKNGIGTDASIPTHINTVEARKYC 600
Query: 326 QV--QAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHV 383
++ + GR+++PT LGITL R Y SID +L LP +R+ IE+Q+ LIA+G+ D + VV
Sbjct: 601 EIVPRDGRRVIPTDLGITLCRAYASIDEELALPTVRAHIEKQLDLIAEGKADKNAVVSQA 660
Query: 384 IQQFKQKFCYFVKKIEAMDALFEAQFSTLVD-SGRILSKCGKCLRYMKYISA------QP 436
+ Q K KF +F K I +D LFEA F++ + + CG+C RY+K ++ +
Sbjct: 661 LMQIKAKFIHFEKNIAIVDNLFEASFASPKELQSTPHTVCGRCRRYLKLQASGRRHGRKT 720
Query: 437 SRLYCGICEEVYYLPQKG-TIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPF 495
RL+C E + P+ +IK + C + +FEL + +++P CP+CY++PP
Sbjct: 721 FRLFCETEAETFECPRNASSIKPWSGRFCEICDFELSIYETSDGERAYPFCPFCYNHPPD 780
Query: 496 EGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGT-------- 547
G TS+S G CPH + + + CP C
Sbjct: 781 FG---------TSSSKSGG---------CPHSVLHPIVSERAIAPCPNCEKETAKDPYYL 822
Query: 548 ----------------------LVLDPV--SAPKWRLCCNMCNCLVFLAQGAHRISTTKE 583
L+LDP+ +WRL C C+ +V L +G ++ + E
Sbjct: 823 ANATLGAAGSSSTAASVVSLPQLLLDPILRKGGRWRLNCTKCDLIVGLPKGLKKVEVSDE 882
Query: 584 -RCPECDS 590
C CD+
Sbjct: 883 HECSACDA 890
>J9FCG0_9SPIT (tr|J9FCG0) DNA topoisomerase OS=Oxytricha trifallax GN=OXYTRI_02606
PE=3 SV=1
Length = 1342
Score = 374 bits (960), Expect = e-101, Method: Compositional matrix adjust.
Identities = 186/401 (46%), Positives = 249/401 (62%), Gaps = 8/401 (1%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--GYEIQLEWQRSKLFDINVAT 70
+YGPCQTPTLGFCV + +I F PE +WS+ I G L+W R K++D V T
Sbjct: 725 TYGPCQTPTLGFCVDQAEKIKKFIPEPYWSIETVIADKDRGKSYSLKWGRGKIYDRTVTT 784
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ +A EV ++ + + + +P GLNTV +LKVAS G H M+ AE LY +
Sbjct: 785 IVHSRIACFDSAEVIDVQKSKAVQGKPQGLNTVKMLKVASKTYGMSAHDTMKTAEHLYLR 844
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+I+YPRTEST Y +F+F L N WG+Y LL +KP+ G D GDHPPIT
Sbjct: 845 GYITYPRTESTTYSANFNFDEILQQHQQNSEWGSYATRLLNGMMVKPKKGVDAGDHPPIT 904
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGG-----ESFHCTGQH 245
P++ A+ LG WKLY +I ++F G++SPD Y + KV F +G E+F G
Sbjct: 905 PVKSASRASLGEREWKLYNFITRNFFGSISPDASYDQVKVLFQVGNKESIIENFKLKGNI 964
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNG 305
++ GF IMPWL DK IP F GQ++EV ++++ EG T P YLTE++LIS MEKNG
Sbjct: 965 LVEHGFLEIMPWLLAADKEIPVFKIGQQVEVRQIKITEGKTQAPGYLTEAKLISRMEKNG 1024
Query: 306 IGTDASIPVHINNICERNYVQV-QAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
IGTDASIP HINNI ER +V V GR+LVPT LG LV+GY IDP+L LP IR IE+
Sbjct: 1025 IGTDASIPTHINNIIERKFVTVLDPGRQLVPTPLGSALVKGYCQIDPELVLPSIRQNIEK 1084
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALF 405
LIAKG+ D +++ HV+ F++KF +F I +M+ +
Sbjct: 1085 SCELIAKGKADFAKILAHVLTCFRKKFEFFRANISSMEKIL 1125
>H2YRK8_CIOSA (tr|H2YRK8) DNA topoisomerase OS=Ciona savignyi PE=3 SV=1
Length = 635
Score = 374 bits (959), Expect = e-100, Method: Compositional matrix adjust.
Identities = 183/356 (51%), Positives = 242/356 (67%), Gaps = 4/356 (1%)
Query: 27 QRYLQINTFKPEKFWSVNPYI--VHSGYEIQLEWQRSKLFDINVATMFQKLVAEDGLLEV 84
Q Y +N F++ + I +HS + L + R ++FD +VA M+ L+ E +
Sbjct: 277 QYYFVLNILYRFAFFNFSNSISWIHSHTILLLAFLRGRIFDQSVAKMYLSLIKESKKAII 336
Query: 85 TEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYPRTESTAYP 144
I++K++TK RP LNTV +L+VAS++L GP AMQ AE LYT+GFISYPRTE+T YP
Sbjct: 337 KNITKKEKTKQRPQALNTVEMLRVASASLNIGPQQAMQAAEHLYTRGFISYPRTETTHYP 396
Query: 145 PSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDML-GND 203
+FDFR ALS Q + +WG YV LL+ G+ KPR G+D GDHPPITPM A E + G+D
Sbjct: 397 ENFDFRSALSTQTRSRSWGAYVSSLLSTGFTKPRKGSDAGDHPPITPMLCATEQEIGGHD 456
Query: 204 AWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAIND- 262
+W+LY+YI +HFI T+SPDC Y V+F I E+F CTG + GFT +MPW +IND
Sbjct: 457 SWRLYEYIVRHFIATLSPDCTYMHTVVQFKIADETFTCTGSLPLKAGFTEVMPWQSINDH 516
Query: 263 KNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICER 322
+ +P+ G + V + EL + T+PPDYLTESELI+LMEK+GIGTDASIP HINNI +R
Sbjct: 517 QTLPTLQTGDECSVERAELLDRKTSPPDYLTESELITLMEKHGIGTDASIPTHINNIGQR 576
Query: 323 NYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHR 378
NYV V +GRKL PT LGI LV GY ID DL P +RS +E+Q+ LIA+G + +
Sbjct: 577 NYVTVISGRKLQPTNLGIMLVHGYNKIDADLVQPTMRSAVEKQLNLIAQGNKNQKK 632
Score = 59.7 bits (143), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 26/48 (54%), Positives = 35/48 (72%), Gaps = 2/48 (4%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV--HSGYEIQLEW 58
SYGPCQTPTLGFCV R+ +I +FKPE FW ++ + ++G I L+W
Sbjct: 204 SYGPCQTPTLGFCVDRHDKIQSFKPEPFWVIDVKVKCPNNGPTISLDW 251
>M2Y2M1_GALSU (tr|M2Y2M1) DNA topoisomerase OS=Galdieria sulphuraria
GN=Gasu_23550 PE=3 SV=1
Length = 853
Score = 365 bits (936), Expect = 4e-98, Method: Compositional matrix adjust.
Identities = 240/650 (36%), Positives = 337/650 (51%), Gaps = 49/650 (7%)
Query: 4 FIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKL 63
F L + SYGPCQTPTLGFCV R +I+ F PE F+ V + + R K+
Sbjct: 206 FSSLDSKLVSYGPCQTPTLGFCVGRLDEISKFSPETFFLVVVNVRKNNRTTNWYSSRGKI 265
Query: 64 FDINVATMFQKLVAE--DGLL-EVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMA 120
F+ VA+ + + G+ ++ + + +E + RP+ LNTV LLK+AS L PH
Sbjct: 266 FERKVASAIVERINSYSSGISGKIIDRTTSKERRHRPLPLNTVELLKLASKRLKMSPHQV 325
Query: 121 MQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYL-KPRL 179
Q+AE LYTQG ISYPRTES+ YP SFD LS TW V+ YL K R
Sbjct: 326 AQVAESLYTQGLISYPRTESSKYPSSFDIEAVLSELEKTSTWFPIVKIFREGKYLNKSRQ 385
Query: 180 G-TDVGDHPPITPMRPAAEDMLGN-DAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGE 237
G D GDHPPITP+R A L N + ++Y+ I F+ +VS D ++ + GE
Sbjct: 386 GGVDKGDHPPITPVRGAERGSLRNAEHERVYELIVYSFLASVSEDAVIMSQQYWMLLSGE 445
Query: 238 SFHCTGQHVITKGFTAI------MPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDY 291
F + + ++ G+ M L +N + F + + IE V L E T PP+Y
Sbjct: 446 KFVFSQRKLVVPGWLEFSNSSNHMESLNMNSEIF--FEQNESIEDFTVSLEEMQTEPPEY 503
Query: 292 LTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDP 351
L+ES+L+ LMEK GIGTDASIP HINNI R YV++ + R+L+PT LGI L RGYQ IDP
Sbjct: 504 LSESDLVGLMEKYGIGTDASIPTHINNIITRGYVRLSSERRLIPTQLGILLYRGYQKIDP 563
Query: 352 DLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFST 411
L P +RS IEQ+I +A GQ+D VV+H + F +KF YF K I+AMD LFE F+
Sbjct: 564 QLVSPVVRSHIEQEIAQVASGQVDAMSVVEHCLSVFWKKFIYFRKHIDAMDDLFETVFTN 623
Query: 412 LVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFEL 471
+ G+ S CG+C RYMK I + +RL+C C + LP G + C +D+FEL
Sbjct: 624 MHSRGKKFSLCGRCNRYMKLIEEKQNRLFCMNCNDTLKLP-PGKFHIMNGNKCSIDSFEL 682
Query: 472 LLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPN 531
+ + G+ +CP C+ +++ +T G G C +CP
Sbjct: 683 VTW-VSSWGRPLLICPKCF-------LDSSTDTNFKEPEWYPGLGCTQLSTCCS-LSCPW 733
Query: 532 SLVSQ---GVCA-CPE---------CSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGA--- 575
Q G+CA C + C G L L P AP ++ CN C+ + +QG+
Sbjct: 734 RQWHQNTIGLCAQCVQQTEVNKSLFCPGVLFLSP-RAPV-QVYCNRCSFSLKFSQGSVVQ 791
Query: 576 HRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLV 625
+ E+C C S + L D + +GC+ CD L +++
Sbjct: 792 VGLEEQDEKCSACHSKKLWFK------SLSD-NVRQKGCLYCDSLFLAVL 834
>F0X3Y0_CRYPV (tr|F0X3Y0) Cgd6_2390 protein OS=Cryptosporidium parvum
GN=cgd6_2390 PE=2 SV=1
Length = 482
Score = 358 bits (919), Expect = 4e-96, Method: Compositional matrix adjust.
Identities = 197/476 (41%), Positives = 272/476 (57%), Gaps = 30/476 (6%)
Query: 158 NNPTWGNYVEGLLTNGYLKPRL-GTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFI 216
NN WG+Y LL G+ PR G D+GDHPPITP+R A ++ L D+W+LY I +HF
Sbjct: 4 NNSVWGSYSSDLLQKGFNLPRKDGLDLGDHPPITPVRSATQNDLDGDSWRLYDLITRHFF 63
Query: 217 GTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAINDKNI-PSFIKGQKIE 275
T+S D K R ++F + GE F +G VI GF+ I A ++ NI P F + +
Sbjct: 64 ATISNDIKMINRTIKFDLNGEIFIISGNQVIDHGFSVIQGRAACHESNIIPDFTLNEVVP 123
Query: 276 VSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVP 335
+ +E+ T PP L+ES+L+SLMEK+GIGTDAS+P HI I ER YV++ +GR+L P
Sbjct: 124 IKNIEILSKETKPPPILSESDLLSLMEKHGIGTDASMPTHIQKIQEREYVKLASGRRLEP 183
Query: 336 TTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFV 395
T LGI LV G +ID +L LP IRS +E+ + LIAKG+ +H V++H + FK KF YF
Sbjct: 184 TKLGIALVHGIMNIDHELVLPKIRSEMEKYVDLIAKGKYNHKAVLKHSLSVFKLKFLYFA 243
Query: 396 KKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYIS-AQPSRLYCGICEEVYYLPQKG 454
+ I ++LF F+ + S +S+CG+C RY+ YIS P RLYC CE +PQ+G
Sbjct: 244 ENISLFESLFRLGFTNITASCSRISRCGQCKRYLTYISNILPQRLYCSFCEIYLDIPQRG 303
Query: 455 TIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIG 514
TIK+YKEL CP+D+FELLL + GK CP CY++PPF +
Sbjct: 304 TIKIYKELKCPIDDFELLL-FIDQKGKKSIFCPRCYNDPPF-----------------LD 345
Query: 515 KGAGMPCILCPHPTCPNSLVSQGVCACP--EC-SGTLVLDPVSAPKWRLCCNMCNCLVFL 571
M C CPH TC SL S ACP +C G + +D S WR C+ C+ +
Sbjct: 346 AKENMLCKFCPHQTCNFSLKSTFFMACPSQDCRDGIITMDSSSTSDWRFDCSRCSISFSI 405
Query: 572 AQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEM 627
+ + ERC +C S +++ K+ T E GC CDE + SL+E+
Sbjct: 406 KKNICERLSLGERCEKCGSRKLKI--CKEKTSQEH----FVGCPNCDEEILSLIEV 455
>Q5CNC8_CRYHO (tr|Q5CNC8) DNA topoisomerase III beta-1 OS=Cryptosporidium hominis
GN=Chro.60278 PE=3 SV=1
Length = 482
Score = 358 bits (918), Expect = 5e-96, Method: Compositional matrix adjust.
Identities = 197/476 (41%), Positives = 270/476 (56%), Gaps = 30/476 (6%)
Query: 158 NNPTWGNYVEGLLTNGYLKPRL-GTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFI 216
NN WG+Y LL G+ PR G D+GDHPPITP+R A ++ L D+W+LY I +HF
Sbjct: 4 NNSVWGSYSSDLLQKGFNLPRKDGLDLGDHPPITPVRSATQNDLDGDSWRLYDLITRHFF 63
Query: 217 GTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWLAINDKNI-PSFIKGQKIE 275
T+S D K R ++F I GE F +G VI GF+ I A ++ NI P F + +
Sbjct: 64 ATISNDIKIINRTIKFDINGEIFIISGNQVIDHGFSVIQGRAACHESNIIPDFTLNEVVP 123
Query: 276 VSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVP 335
+ +E+ T PP L+ES+L+SLMEK+GIGTDAS+P HI I ER YV++ +GR+L P
Sbjct: 124 IKNIEILSKETKPPPILSESDLLSLMEKHGIGTDASMPTHIQKIQEREYVKLASGRRLEP 183
Query: 336 TTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFV 395
T LGI LV G +ID +L LP IRS +E+ + LIAKG+ +H V++H + FK KF YF
Sbjct: 184 TKLGIALVHGIMNIDHELVLPKIRSEMEKYVDLIAKGKYNHKAVLKHSLSVFKLKFLYFA 243
Query: 396 KKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYIS-AQPSRLYCGICEEVYYLPQKG 454
+ I ++LF F+ + S +S+CG+C RY+ YIS P RLYC CE +PQ+G
Sbjct: 244 ENITLFESLFRLGFTNITASCSRISRCGQCKRYLTYISNILPQRLYCSFCEIYLDIPQRG 303
Query: 455 TIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIG 514
TIK+YKEL CP+D+FELLL + GK CP CY++PPF +
Sbjct: 304 TIKIYKELKCPIDDFELLL-FIDQKGKKSIFCPRCYNDPPF-----------------LD 345
Query: 515 KGAGMPCILCPHPTCPNSLVSQGVCACPE--C-SGTLVLDPVSAPKWRLCCNMCNCLVFL 571
M C CPH TC SL S ACP C G + +D S WR C+ C +
Sbjct: 346 AKENMLCKFCPHQTCNFSLKSTFFMACPSQGCRDGIITMDSSSTSDWRFDCSRCTISFSI 405
Query: 572 AQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVEM 627
+ + ERC +C S +++ K+ T E GC CDE + +L+E+
Sbjct: 406 KRNICERLSLGERCEKCGSRKLKI--GKEKTSQEH----FVGCPNCDEEILNLIEV 455
>G0QK41_ICHMG (tr|G0QK41) DNA topoisomerase (Fragment) OS=Ichthyophthirius
multifiliis (strain G5) GN=IMG5_012580 PE=3 SV=1
Length = 789
Score = 358 bits (918), Expect = 5e-96, Method: Compositional matrix adjust.
Identities = 193/491 (39%), Positives = 279/491 (56%), Gaps = 35/491 (7%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEI--QLEWQRSKLFDINVAT 70
+YGPCQTPTLGFCV+R +I +FKP+ F+ + +I Q ++ +F+ A
Sbjct: 265 TYGPCQTPTLGFCVRREDEIKSFKPKLFYRLLIQFRKKDEQIDTQAVFENGNIFNQQEAN 324
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + +V ++ ++ K RP GLNTV LLK+ SS L P M +AE+LY Q
Sbjct: 325 SLLTKIIKQKEGQVFDVFSEKGIKGRPEGLNTVQLLKMGSSYLHLSPQQTMHVAEKLYLQ 384
Query: 131 GFISYPRTESTAYPPSFDFRGALSA--QANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPP 188
GFI+YPRTEST+Y +F F + Q N + L NG KP+ G D+GDHPP
Sbjct: 385 GFITYPRTESTSYAKNFPFEDICRSLCQLKNSQVSQDAQLLFRNGIYKPKQGVDIGDHPP 444
Query: 189 ITPMRPA-AEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVI 247
ITP + + L N+ LY+Y+C+HF+ ++S DC + + ++ ++ G +F CTG +I
Sbjct: 445 ITPTNYVPSNNQLRNEESNLYEYVCKHFMASISADCSFMKSQISINVNGLNFKCTGVQII 504
Query: 248 TKGFTAIMPWLAINDKNIP-SFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
KGF IM W++I++ N+P +KG K+E++ L + TPP YLTE+ELI+LMEKN I
Sbjct: 505 NKGFIEIMDWISISENNLPIGILKGNKVEITTTRLEQEYQTPPGYLTETELINLMEKNKI 564
Query: 307 GTDASIPVHINNICERNYVQVQA-GRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQ 365
GTDAS+ HIN ICER YV++ R+L+P+ +G L++GYQ ID L LP+IRS IE Q
Sbjct: 565 GTDASLATHINTICEREYVKISGNNRQLIPSDMGRCLIKGYQLIDESLVLPEIRSQIENQ 624
Query: 366 ITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKC 425
+ IAKG F + K +E D L +A + SKCG+C
Sbjct: 625 VDQIAKGY---------------SLFSSYYKNVE--DQLVQA---------KPFSKCGQC 658
Query: 426 LRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELL-LCSMGPDGKSFP 484
R+MK I + + +C C+ +P G K+ E CP D ++++ S P SF
Sbjct: 659 KRFMKIIE-KAGKFFCEQCQINLIVPTGGKYKIVGEKYCPYDGYQVVFFTSANPPNVSFD 717
Query: 485 LCPYCYSNPPF 495
LCP CY+ P
Sbjct: 718 LCPKCYTQSPL 728
>B8CGH9_THAPS (tr|B8CGH9) DNA topoisomerase OS=Thalassiosira pseudonana
GN=THAPSDRAFT_25879 PE=3 SV=1
Length = 1417
Score = 344 bits (883), Expect = 6e-92, Method: Compositional matrix adjust.
Identities = 223/664 (33%), Positives = 319/664 (48%), Gaps = 111/664 (16%)
Query: 18 QTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDIN-VATMFQKLV 76
TPTLGFCVQR++++ TFKPE +W ++ ++++G + W + F+ N V + K
Sbjct: 781 HTPTLGFCVQRHVEMETFKPEPYWLMDLGVMNAGTMCRAVWDSGRSFNRNKVDDLVAKCK 840
Query: 77 AEDGLL--EVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFIS 134
+ +V + K + RPV +NTV +LK S LG GPH A+ +AERLY G++S
Sbjct: 841 NSSSAVFAKVDAVVTKNRHQGRPVPMNTVAMLKACSKVLGIGPHAALSIAERLYLSGYLS 900
Query: 135 YPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRP 194
YPRTEST YP SFD G L Q+ + WG YV LL +G + G D+GDH
Sbjct: 901 YPRTESTKYPKSFDIVGTLKEQSYDNRWGQYVGELLKSGPNVGKGGADMGDH-------- 952
Query: 195 AAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAI 254
+ S S HC ++T GF AI
Sbjct: 953 -----------------------------------LTISTSSISLHC---QLVTPGFLAI 974
Query: 255 MPWLAIND-------------KNIPSFIKGQKIEV-----------------SKVELYEG 284
+ + D K +P F +G + + + +++ E
Sbjct: 975 VLYKQYGDEADEGNGGDDEEEKALPPFAEGDQFGLFFAGSAKSGKVCVSDKWATLDVKEK 1034
Query: 285 TTTPPDYLTESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVR 344
TTPP YLTESELIS MEK+GIGTDASI HI NI +RNYV++ +GRKL P+ LG+ L +
Sbjct: 1035 MTTPPTYLTESELISKMEKHGIGTDASISTHIENIMKRNYVELISGRKLKPSRLGLVLAQ 1094
Query: 345 GYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDAL 404
GY ID L LP IR+ IE + IAKG D VV+ I+ F KF YF + + MD L
Sbjct: 1095 GYHLIDSSLVLPQIRADIELECNKIAKGLADRDDVVKKAIEMFSAKFLYFAENVNKMDIL 1154
Query: 405 FEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSC 464
F + F+ L D G+ ++CG RY+++I+ P LP G +K + C
Sbjct: 1155 FGSSFAQLQDVGKPFTRCGFTRRYLQFITGPPP------------LPIGGELKQWTGRHC 1202
Query: 465 PLD--NFELLLCSMGPDGKSFPLCPYCYSNP-----PFEGIEALINTAKTSTSGK---IG 514
P+ NFEL L S+G ++FPLCP C++NP P G A+ + K I
Sbjct: 1203 PVVGCNFELCLYSVGAPARTFPLCPNCFNNPRPEWGPVPGENAVAKPGEEDDEAKERSIR 1262
Query: 515 KGAGMP-CILCPHPTCPNSLVSQGVCACPECSGTLVLDPVSAP--------KWRLCCNMC 565
+ AG C CPH + V P+ G L+LDP P KWRL
Sbjct: 1263 RLAGKNICRECPHGDKHPLIEDMTVSPDPDSGGVLILDPHLGPKLTFLMVSKWRLVSTRE 1322
Query: 566 NCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDGSTLHRGCILCDELLHSLV 625
+V L + +++ ++ ++ ++F +P+ DG + C DE+L LV
Sbjct: 1323 PTIVHLPKSIDKVTILDKKDEVLGCHMMSIEFKDGESPI-DGKKKYVSCFAIDEVLQGLV 1381
Query: 626 EMKH 629
+ H
Sbjct: 1382 RVHH 1385
>J9E791_WUCBA (tr|J9E791) DNA topoisomerase OS=Wuchereria bancrofti GN=WUBG_10928
PE=3 SV=1
Length = 401
Score = 343 bits (880), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 180/385 (46%), Positives = 248/385 (64%), Gaps = 29/385 (7%)
Query: 255 MPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIP 313
M W I D +KG K+ + ++ E TTTPPDYLTESELISLMEK+GIGTDASIP
Sbjct: 1 MVWQKIEEDAQNYDIVKGSKVNLKDGKICEYTTTPPDYLTESELISLMEKHGIGTDASIP 60
Query: 314 VHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQ 373
VHI+NIC+RNYV V++ R+L PT LGI LV GY+ ID +L LP +RS +E Q+ LIAKG
Sbjct: 61 VHISNICQRNYVTVESRRRLKPTKLGIALVHGYRKIDSELVLPTMRSEVESQLNLIAKGY 120
Query: 374 IDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYIS 433
D V HV++ F+ KF YF + I +D+LFE F++L SG+ S+CGKC R+MK ++
Sbjct: 121 ADFCSVKNHVLENFRLKFIYFAENIGLVDSLFEDSFTSLAASGKPFSRCGKCRRFMKLVA 180
Query: 434 AQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGPDGK---SFPLCPY 488
++P RL+C C++ Y LP + G ++L+ E CPLD+F+L+ GP GK S+ LCPY
Sbjct: 181 SKPQRLHCPNCQDTYSLPSAKDGLLRLHGENKCPLDDFDLIY-WQGPGGKLSMSYVLCPY 239
Query: 489 CYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP-ECS-- 545
CY+NPPFEG++ KG+G C C +P CP+S ++ GV CP C
Sbjct: 240 CYNNPPFEGMK---------------KGSG--CHECCNPVCPHSFLTLGVVQCPRRCGAG 282
Query: 546 -GTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPL 604
G LVLDP SAPKWR+ CN C+ +V L +GA R+ ++C +C + + ++ K +PL
Sbjct: 283 HGVLVLDPQSAPKWRISCNKCSAVVGLFEGALRVKVLTKQCEDCGAQLFFAEYKDK-SPL 341
Query: 605 EDGSTLHRGCILCDELLHSLVEMKH 629
+ T +RGC+ CD+ + LV H
Sbjct: 342 PEERTTYRGCVFCDKSISHLVNFNH 366
>I7M4N6_TETTS (tr|I7M4N6) DNA topoisomerase OS=Tetrahymena thermophila (strain
SB210) GN=TTHERM_00497920 PE=3 SV=1
Length = 916
Score = 337 bits (864), Expect = 9e-90, Method: Compositional matrix adjust.
Identities = 186/494 (37%), Positives = 277/494 (56%), Gaps = 17/494 (3%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQL---EWQRSKLFDINVA 69
S+GPCQTPTLGFCV+R QI F P + V + S + Q+ Q+ L
Sbjct: 415 SFGPCQTPTLGFCVEREDQIKKFIPSLLYKVKLTLQGSDNKTQMLAYSEQKETLSKEKAQ 474
Query: 70 TMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYT 129
+FQ + E + ++ +S + + PVGLNTV +LK ASS+L P M AE LY
Sbjct: 475 YIFQSIKLEKHI-QIVSVSSETLVEECPVGLNTVEMLKAASSSLNMSPQQTMDAAENLYL 533
Query: 130 QGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPI 189
+GFI+YPRTESTAY SF+F+ LS+ + +G + + LL +GY+ P+ G D DHPPI
Sbjct: 534 KGFITYPRTESTAYSSSFNFKKVLSSLQQDIEYGKFAQNLLNDGYIIPQKGNDTEDHPPI 593
Query: 190 TPM----RPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
TP RP E ++ +LY YI +HFI ++ D +Y + + + F
Sbjct: 594 TPTSNYPRPENEGLISPQEKQLYDYISKHFIASLYDDYEYKKLNITCQVKNYQFISEAIR 653
Query: 246 VITKGFTAIMPWLAINDKNIPSFIKGQ--KIEVSKVELYEGTTTPPDYLTESELISLMEK 303
V +G+T ++ + D+NI Q K ++ + + E ++PP YL+ESELI LM K
Sbjct: 654 VEKQGYTKVIKSTQL-DQNIIQIDVKQSSKFQIKNISIEEEYSSPPRYLSESELIDLMSK 712
Query: 304 NGIGTDASIPVHINNICERNYVQV-QAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
N IGTDASIP HI NI +R YV++ Q R L+PT LG +++ GY+ ID +L P IR+ I
Sbjct: 713 NSIGTDASIPTHIQNIVDRKYVEIDQKNRTLIPTQLGRSIIDGYRKIDEELVSPQIRAQI 772
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMD---ALFEAQFSTLVDSGRIL 419
E + IAKG + +V+ + F+ K+ FV I+ MD LF + ++ + + L
Sbjct: 773 ENSVNQIAKGDKEFSQVLNESLGLFQNKYINFVYNIKNMDNLVGLFCKTYKEVLQTAKPL 832
Query: 420 SKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELL-LCSMGP 478
SKCG C MK+I Q ++ C C+ +YLP+ G +K+ ++ C DNF+++ S
Sbjct: 833 SKCGFCQSIMKFI-EQSEQVVCQKCDIKFYLPKSGDLKISEDKICLKDNFQIIQFTSQNS 891
Query: 479 DGKSFPLCPYCYSN 492
+ +CP CYS+
Sbjct: 892 NEGVIDICPNCYSD 905
>N9UWP2_ENTHI (tr|N9UWP2) DNA topoisomerase 3-beta-1, putative OS=Entamoeba
histolytica HM-1:IMSS-A GN=EHI7A_032540 PE=4 SV=1
Length = 840
Score = 335 bits (860), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 209/626 (33%), Positives = 311/626 (49%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ I H G L+ + V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKRFDNKSEVED 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V ++S + KSRPVGLNTV +LKVAS LG GP M +AE+LYT+
Sbjct: 265 IVKSCKGVQG--KVIKMSVNELKKSRPVGLNTVEMLKVASVKLGLGPQDTMSIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG P G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSYFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + KL+ +I F+ ++ D + + V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKKLFDFITNTFLASIYKDSTFQKVSVSVQIGNYTFNGSGKILKDPG 441
Query: 251 FTAIMPWLAINDK-------NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I +D+ SFI+G + S ++ +G T PDYLTE ELISLMEK
Sbjct: 442 FMKITNHYDEDDELKDSDLIKPTSFIEGNTVIPSMFDIVKGMTKCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L R +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + + ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEDNF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE+++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKC-CPICKFEIIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQDHSSCLQCSNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C S + VD K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHL-VDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTMTKGCMNCDSSIKKLYTIK 800
>M7X9I8_ENTHI (tr|M7X9I8) DNA topoisomerase 3-beta-1, putative OS=Entamoeba
histolytica HM-3:IMSS GN=KM1_067500 PE=4 SV=1
Length = 840
Score = 335 bits (860), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 209/626 (33%), Positives = 311/626 (49%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ I H G L+ + V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKRFDNKSEVED 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V ++S + KSRPVGLNTV +LKVAS LG GP M +AE+LYT+
Sbjct: 265 IVKSCKGVQG--KVIKMSVNELKKSRPVGLNTVEMLKVASVKLGLGPQDTMSIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG P G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSYFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + KL+ +I F+ ++ D + + V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKKLFDFITNTFLASIYKDSTFQKVSVSVQIGNYTFNGSGKILKDPG 441
Query: 251 FTAIMPWLAINDK-------NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I +D+ SFI+G + S ++ +G T PDYLTE ELISLMEK
Sbjct: 442 FMKITNHYDEDDELKDSDLIKPTSFIEGNTVIPSMFDIVKGMTKCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L R +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + + ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEDNF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE+++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKC-CPICKFEIIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQDHSSCLQCSNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C S + VD K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHL-VDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTMTKGCMNCDSSIKKLYTIK 800
>M3TTG7_ENTHI (tr|M3TTG7) DNA topoisomerase OS=Entamoeba histolytica HM-1:IMSS-B
GN=EHI8A_029480 PE=3 SV=1
Length = 840
Score = 335 bits (860), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 209/626 (33%), Positives = 311/626 (49%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ I H G L+ + V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKRFDNKSEVED 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V ++S + KSRPVGLNTV +LKVAS LG GP M +AE+LYT+
Sbjct: 265 IVKSCKGVQG--KVIKMSVNELKKSRPVGLNTVEMLKVASVKLGLGPQDTMSIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG P G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSYFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + KL+ +I F+ ++ D + + V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKKLFDFITNTFLASIYKDSTFQKVSVSVQIGNYTFNGSGKILKDPG 441
Query: 251 FTAIMPWLAINDK-------NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I +D+ SFI+G + S ++ +G T PDYLTE ELISLMEK
Sbjct: 442 FMKITNHYDEDDELKDSDLIKPTSFIEGNTVIPSMFDIVKGMTKCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L R +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + + ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEDNF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE+++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKC-CPICKFEIIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQDHSSCLQCSNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C S + VD K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHL-VDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTMTKGCMNCDSSIKKLYTIK 800
>M2RCU9_ENTHI (tr|M2RCU9) DNA topoisomerase OS=Entamoeba histolytica KU27
GN=EHI5A_056600 PE=3 SV=1
Length = 840
Score = 335 bits (860), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 209/626 (33%), Positives = 311/626 (49%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ I H G L+ + V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKRFDNKSEVED 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V ++S + KSRPVGLNTV +LKVAS LG GP M +AE+LYT+
Sbjct: 265 IVKSCKGVQG--KVIKMSVNELKKSRPVGLNTVEMLKVASVKLGLGPQDTMSIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG P G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSYFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + KL+ +I F+ ++ D + + V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKKLFDFITNTFLASIYKDSTFQKVSVSVQIGNYTFNGSGKILKDPG 441
Query: 251 FTAIMPWLAINDK-------NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I +D+ SFI+G + S ++ +G T PDYLTE ELISLMEK
Sbjct: 442 FMKITNHYDEDDELKDSDLIKPTSFIEGNTVIPSMFDIVKGMTKCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L R +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + + ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEDNF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE+++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKC-CPICKFEIIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQDHSSCLQCSNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C S + VD K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHL-VDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTMTKGCMNCDSSIKKLYTIK 800
>C4M656_ENTHI (tr|C4M656) DNA topoisomerase OS=Entamoeba histolytica
GN=EHI_042880 PE=3 SV=1
Length = 840
Score = 335 bits (860), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 209/626 (33%), Positives = 311/626 (49%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ I H G L+ + V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKRFDNKSEVED 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V ++S + KSRPVGLNTV +LKVAS LG GP M +AE+LYT+
Sbjct: 265 IVKSCKGVQG--KVIKMSVNELKKSRPVGLNTVEMLKVASVKLGLGPQDTMSIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG P G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSYFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + KL+ +I F+ ++ D + + V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKKLFDFITNTFLASIYKDSTFQKVSVSVQIGNYTFNGSGKILKDPG 441
Query: 251 FTAIMPWLAINDK-------NIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I +D+ SFI+G + S ++ +G T PDYLTE ELISLMEK
Sbjct: 442 FMKITNHYDEDDELKDSDLIKPTSFIEGNTVIPSMFDIVKGMTKCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L R +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + + ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEDNF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE+++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKC-CPICKFEIIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQDHSSCLQCSNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C S + VD K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHL-VDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTMTKGCMNCDSSIKKLYTIK 800
>A8B577_GIAIC (tr|A8B577) DNA topoisomerase III OS=Giardia intestinalis (strain
ATCC 50803 / WB clone C6) GN=GL50803_15190 PE=3 SV=1
Length = 973
Score = 334 bits (857), Expect = 5e-89, Method: Compositional matrix adjust.
Identities = 206/589 (34%), Positives = 307/589 (52%), Gaps = 48/589 (8%)
Query: 2 ALFIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQ-- 59
A F L + SYGPCQTPTL FCV R+ +I F+P++ +S++ + L WQ
Sbjct: 192 AQFADLQSSVISYGPCQTPTLSFCVSRHDEIQRFRPKQIFSLDVCALIGDQPHSLRWQGV 251
Query: 60 ---RSKLFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFG 116
++ + +F K + L+V + T RP+ +NTV LLK AS+ LG
Sbjct: 252 PSESREVIEEKRTGLFGKSATK--CLKVLSFKSSKSTLPRPLPMNTVALLKAASTVLGLS 309
Query: 117 PHMAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSA--QANNPTWGNYVEGLLTNG- 173
P+ AM LAERLY G+ISYPRTEST YP ++ R + A ++++ + LL +
Sbjct: 310 PNSAMALAERLYIAGYISYPRTESTTYPSGYNLREIVLALKESSSTRISQCAQNLLPSSK 369
Query: 174 --------YLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKY 225
Y PR GTD GDHPPI P D+ N+ LY I +HF+ TVSPD Y
Sbjct: 370 KSSDESVRYTNPRRGTDQGDHPPIMPTGLIPHDVSSNE-LSLYNLITKHFLATVSPDAVY 428
Query: 226 ARRKVEF---SIGGESFHCTGQHVITKGFTAI---MPWLAINDKNIPSFIKGQKIEVSKV 279
+ + + E+F + V+ +G+ A+ + ++ D ++ + + I +SK
Sbjct: 429 SHSSLTLQSVDMPSETFLLSITDVVDQGWKALYSATEFSSMRDNDLSDDLADESISLSKE 488
Query: 280 ELYE-----------------GTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICER 322
L G T PP YL+ES+L+ LMEK+GIGTDAS+ HI NI R
Sbjct: 489 TLQAISATGATLTIASAAIKAGMTKPPGYLSESDLLGLMEKHGIGTDASMATHIGNIVTR 548
Query: 323 NYVQVQ-AGRK--LVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRV 379
YV+++ GR+ LVPT++GI+L+ GYQ ID DL P +R+ IE+ +T IA+G+I +
Sbjct: 549 AYVELRVTGRRRCLVPTSMGISLIHGYQLIDGDLSSPQLRASIERDVTRIAEGKIRKDVL 608
Query: 380 VQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRL 439
V V+ +F KF +F + I ++AL A+F+++ +GR CG+C RY I P R+
Sbjct: 609 VNQVLSKFLTKFLHFKQNIGKLEALLNAKFTSIKKAGRPFILCGECHRYTDLIEQYPPRV 668
Query: 440 YCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIE 499
YC C+++Y +P +GT CP D + L+L K C +CY+ E
Sbjct: 669 YCVTCDKLYTIPMRGTFIEIPSRKCPYDGWPLILHMAEATQKRTFFCLHCYTF-GLNKEE 727
Query: 500 AL--INTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSG 546
AL + T S I + + C +C + C SL+ V AC C+
Sbjct: 728 ALTQLQTVAADGSTDIEQTKAITCGMCLNSLCQMSLLKTQVGACWHCNA 776
>R1ENA1_EMIHU (tr|R1ENA1) Uncharacterized protein OS=Emiliania huxleyi CCMP1516
GN=EMIHUDRAFT_74124 PE=4 SV=1
Length = 920
Score = 334 bits (857), Expect = 7e-89, Method: Compositional matrix adjust.
Identities = 218/662 (32%), Positives = 313/662 (47%), Gaps = 57/662 (8%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTP LGF V+R + +F P W+V G ++ EW R +LFD +A M
Sbjct: 232 SYGPCQTPALGFVVRRDHERRSFTPHPHWAVESDGGAGGASLRPEWSRGRLFDRRIALML 291
Query: 73 QKLV---AEDG-LLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLY 128
+ V A+DG V + E++E + P LNTV L ++ASS LG G + AMQLAE LY
Sbjct: 292 LQRVRAAADDGDGASVLGVGEEREDRRPPSPLNTVELGRLASSRLGLGAYSAMQLAEELY 351
Query: 129 TQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPP 188
+GF+SYPRTES+ +PP FDF L A +P W L+ G G D GDHPP
Sbjct: 352 LRGFLSYPRTESSGFPPGFDFLTPLEELAAHPAWSETASRLVELGA----RGKDAGDHPP 407
Query: 189 ITPMRPAAEDMLGNDA-WKLYQY----------ICQHFIGTVSPDCKYARRKVEFSIGGE 237
ITP R A D +G W++Y+ + Q F+ + + + F + GE
Sbjct: 408 ITPARAAGPDEVGGGVRWRMYEMAPHRTSTPPPVTQTFLAALGCAARVRLTRARFGVAGE 467
Query: 238 SFHCTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESEL 297
F +G V G+ MP + ++P G+ + V L EG T PP L+E+EL
Sbjct: 468 EFTSSGLAVEEAGWYEAMPHRRPAEVSLPPLRSGEALRVRVAVLREGETAPPPPLSEAEL 527
Query: 298 ISLMEKNGIGTDASIPVHINNICERNYVQV-----QAGRKLVPTTLGITLVRGYQSIDPD 352
I ME G+GTDASI HI I R YVQ+ + G PT LG LV G +IDP+
Sbjct: 528 IGAMEAAGVGTDASIAGHIKAIEARRYVQLVGRGERGGDAFEPTPLGRALVEGCAAIDPE 587
Query: 353 LCLPDIRSFIEQQITLIAKGQIDHHR----------VVQHVIQQFKQKFCYFVKKIEAMD 402
L +RS +E Q+ +A G+ R V++H + +F++KF +F + A
Sbjct: 588 L---QVRSHVEAQLRRVASGEARERRGETEAASRADVLRHCLGEFRRKFAFFTQSARAAA 644
Query: 403 ALFEAQFSTL-VDSGRILSKCGKCLRYMK-YISAQPSRLYCGICEEVYYLPQKGTIKLYK 460
A + R R + I A P +L+ ++ LP G++K +
Sbjct: 645 APLRRPLLAPHAHAARPRQPLAPRHRVIAPRIGATP-QLFHPSSGRLWSLPAGGSVKPHS 703
Query: 461 ELSCPLDNFELLLCS-MGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGM 519
CP FEL L S P +++PLCP C+ + +G + +T A +
Sbjct: 704 GRICPACGFELCLFSPRAPPSRAYPLCPSCFDDSLDDGAAGIASTG-ADVDASAETFAAV 762
Query: 520 PCILCPHPTCPNSLVSQGVCACP---ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAH 576
PH ++ CACP G L+LDP P+WRL + L H
Sbjct: 763 YASGSPHGESHPAVAPLVACACPVSGREGGALLLDPRGGPEWRLVSTRASFAYRLPPFIH 822
Query: 577 RISTTKERCPECDSS----------IIEVDFNKKATPLEDGSTLHRGCILCDELLHSLVE 626
+ C CD++ + V+F++ +P+E G T H GC+ DELL +L E
Sbjct: 823 SLRVGAP-C-GCDAARGGDGVVGCRFLHVEFHRDYSPIEGGGTAHTGCLRSDELLQALCE 880
Query: 627 MK 628
+
Sbjct: 881 FE 882
>K2G4I6_ENTNP (tr|K2G4I6) DNA topoisomerase OS=Entamoeba nuttalli (strain P19)
GN=ENU1_206580 PE=3 SV=1
Length = 840
Score = 333 bits (853), Expect = 2e-88, Method: Compositional matrix adjust.
Identities = 208/626 (33%), Positives = 312/626 (49%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ I H G L+ + V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKHFDNKSEVED 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V +++ + KSRPVGLNTV +LKVAS LG GP M +AE+LYT+
Sbjct: 265 IVKSCKGIQG--KVIKMNVNELKKSRPVGLNTVEMLKVASVKLGLGPQETMSIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG P G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSHFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + +L+ +I F+ ++ D + R V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKRLFDFITNTFLASIYKDSTFQRVSVSVQIGNYTFNGSGKVLKDPG 441
Query: 251 FTAIMPWL----AINDKNI---PSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I + D ++ SFI+G + S ++ +G T PDYLTE ELISLMEK
Sbjct: 442 FMKITNHYDEDEELKDSDLIKPTSFIEGNIVIPSMFDIVKGMTKCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L R +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + K ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKKNLKVLEDNF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE+++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKC-CPICKFEIIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQEHSSCLQCCNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C S + +D K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHL-IDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTMIKGCMNCDSSIKKLYTIK 800
>E1F9F6_GIAIA (tr|E1F9F6) DNA topoisomerase III OS=Giardia intestinalis (strain
P15) GN=GLP15_3837 PE=3 SV=1
Length = 973
Score = 328 bits (841), Expect = 5e-87, Method: Compositional matrix adjust.
Identities = 201/589 (34%), Positives = 303/589 (51%), Gaps = 48/589 (8%)
Query: 2 ALFIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQ-- 59
A F L + SYGPCQTPTL FCV R+ +I F+P++ +S++ + L WQ
Sbjct: 192 AQFADLQSSVISYGPCQTPTLSFCVSRHDEIQRFRPKQIFSLDVCALIGDQLCPLRWQGV 251
Query: 60 ---RSKLFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFG 116
++ + A + +K + L+V + T RP+ +NTV LLK AS+ LG
Sbjct: 252 PSESREVIEEKRARLLEKSATK--CLKVLSFKSSKSTLPRPLPMNTVALLKAASTVLGLS 309
Query: 117 PHMAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSA--QANNPTWGNYVEGLLTNG- 173
P+ AM LAERLY G+ISYPRTEST YP ++ R + A ++++ + LL +
Sbjct: 310 PNSAMALAERLYIAGYISYPRTESTTYPSGYNLREIVLALKESSSTRISQSAQNLLPSSK 369
Query: 174 --------YLKPRLGTDVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKY 225
Y PR GTD GDHPPI P + G D LY I +HF+ TVSPD Y
Sbjct: 370 KSVDENVRYTNPRKGTDQGDHPPIMPTGLIPHGVSG-DELSLYNLITKHFLATVSPDAVY 428
Query: 226 ARRKVEF---SIGGESFHCTGQHVITKGFTAI---MPWLAINDKNIPSFIK--------- 270
+ + E+F + VI +G+ A+ + ++ D ++ +
Sbjct: 429 GHSSLTLQSVDVPSETFLFSVTEVIDQGWKALYSTTEFTSMQDNDLSDDLADENLLLDKE 488
Query: 271 --------GQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHINNICER 322
G + ++ + G T PP YL+ES+L+ LMEK+GIGTDAS+ HI NI R
Sbjct: 489 TLQAISATGATLTIASAAIKAGMTRPPAYLSESDLLGLMEKHGIGTDASMATHIGNIVTR 548
Query: 323 NYVQVQ-AGRK--LVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHHRV 379
YV+++ GR+ LVPT++GI+L+ GYQ ID DL P +R+ IE+ +T IA+G+I +
Sbjct: 549 AYVELRVTGRRRCLVPTSMGISLIHGYQLIDGDLSSPQLRASIERDVTRIAEGKIKKDVL 608
Query: 380 VQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYISAQPSRL 439
V V+ +F KF F + I ++AL A+F+++ +GR CG+C RY I P R+
Sbjct: 609 VNQVLSKFLTKFLNFKQNISKLEALLNAKFTSIKKAGRPFILCGECHRYTDLIEQYPPRV 668
Query: 440 YCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIE 499
YC C+++Y +P +G + CP D + L+L + C +CY+ E
Sbjct: 669 YCVTCDKLYTIPMRGKLIEIPSRKCPYDGWPLILHVAEATQRRTFFCLHCYTF-GLSKEE 727
Query: 500 ALINTAKTSTSGKIG--KGAGMPCILCPHPTCPNSLVSQGVCACPECSG 546
AL+ + G I + + C +C + C SL V AC C+
Sbjct: 728 ALMQLQTAAADGNIDIEQTKTITCGMCLNSLCQMSLPRTQVGACWHCNA 776
>B0ERJ9_ENTDS (tr|B0ERJ9) DNA topoisomerase OS=Entamoeba dispar (strain ATCC
PRA-260 / SAW760) GN=EDI_037970 PE=3 SV=1
Length = 840
Score = 328 bits (841), Expect = 5e-87, Method: Compositional matrix adjust.
Identities = 206/626 (32%), Positives = 315/626 (50%), Gaps = 39/626 (6%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV-HSGYEIQLEWQRSKLFDINVAT 70
S+GPCQTPTLGFCV R +I+ F + F+++ + H G L+ + +V
Sbjct: 205 ISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVILEDHEGRNKTLKLDKCFDNKSDVDD 264
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + G +V +++ + KSRP+GLNTV +LK AS LG GP M++AE+LYT+
Sbjct: 265 IVKSCKGVQG--KVIKMNVNELKKSRPIGLNTVEMLKAASIKLGLGPQDTMRIAEKLYTR 322
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
G+ISYPRTEST Y F+F L+ + V+ + NG PR G D GDHPPIT
Sbjct: 323 GYISYPRTESTKYSSYFNFDDILNNLQETNQFREKVQLVKQNGINIPRNGEDKGDHPPIT 382
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P+ E L + KL+ +I F+ ++ D + + V IG +F+ +G+ + G
Sbjct: 383 PLNYPNE-YLNDSEKKLFDFITNTFLASIYKDSIFQKVNVSIQIGNYTFNGSGKVLKDPG 441
Query: 251 FTAIMPWL----AINDKNI---PSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
F I+ I D ++ SFI+G + S ++ +G TT PDYLTE ELISLMEK
Sbjct: 442 FKKIISRYDEDEEIKDSDLIKPTSFIEGDIVIPSMFDIVKGMTTCPDYLTEYELISLMEK 501
Query: 304 NGIGTDASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
NGIGTDASIPVHI NI R YV + + R L PT +G+ L + +++D +L P IR+ I
Sbjct: 502 NGIGTDASIPVHIQNIITREYVSLDTSKRTLRPTKIGLALAKTLETVDKNLITPQIRAHI 561
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKC 422
E ++ IA+G+ + V++ + F+Q + + + ++ ++ F A + + R+ SKC
Sbjct: 562 ESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEENF-APLYQVQEQSRLFSKC 620
Query: 423 GKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKS 482
GKC R + + + L C C + LPQ + + CP+ FE ++ S K
Sbjct: 621 GKCGRILLKVIGDQTYLSCPNCSLKFNLPQNVSYSQQTKC-CPICKFETIMTSSLKSTKK 679
Query: 483 FPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACP 542
+CP CY+ + K C+ C +P C S C C
Sbjct: 680 EMVCPGCYNE-----------------KNQFMKQEHSSCLQCSNPECKLSYERTKTCLCS 722
Query: 543 ECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKAT 602
C G + L + KW CN C+ + + E C +C + + VD K
Sbjct: 723 VCGGVMCLSSLQN-KWSCFCNTCDSHMEWIDTIKKALPNDEICGKCKTYHL-VDLTMK-- 778
Query: 603 PLEDGSTLHRGCILCDELLHSLVEMK 628
+T+ +GC+ CD + L +K
Sbjct: 779 ----DNTVIKGCMNCDSTIKKLYTIK 800
>C0PCH2_MAIZE (tr|C0PCH2) Uncharacterized protein OS=Zea mays PE=2 SV=1
Length = 246
Score = 323 bits (827), Expect = 2e-85, Method: Compositional matrix adjust.
Identities = 157/246 (63%), Positives = 179/246 (72%), Gaps = 5/246 (2%)
Query: 429 MKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM-GPDGKSFPLCP 487
MKYIS QP RLYC CE+VYYLPQ G+IKLYKE+ CPLD FELLL SM GPD KSFPLCP
Sbjct: 1 MKYISTQPMRLYCITCEDVYYLPQNGSIKLYKEIVCPLDGFELLLFSMVGPDAKSFPLCP 60
Query: 488 YCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVSQGVCACPECSGT 547
+CY+ PPFEGI+ L K +GK+GKGAGMPC LCPHPTC S+++QGVCACPECSGT
Sbjct: 61 FCYNCPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGT 120
Query: 548 LVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKERCPECDSSIIEVDFNKKATPLEDG 607
L+LDPVSAPKWRL CNMCNC+V L AHRI+TT ++C C+S+IIEVDFNKK TPL+DG
Sbjct: 121 LILDPVSAPKWRLYCNMCNCIVLLPHAAHRITTTDKKCLTCESTIIEVDFNKKTTPLQDG 180
Query: 608 STLHRGCILCDELLHSLVEMKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMV----DPK 663
+TLH GCILCD+LLHSL+EMKH DPK
Sbjct: 181 ATLHEGCILCDDLLHSLIEMKHGKSFFIRRGRGRGRGRGRGRGSSRGRGRRGNSRYDDPK 240
Query: 664 MSFRDF 669
MSFRDF
Sbjct: 241 MSFRDF 246
>D2VSX3_NAEGR (tr|D2VSX3) Predicted protein OS=Naegleria gruberi
GN=NAEGRDRAFT_81118 PE=3 SV=1
Length = 1015
Score = 317 bits (812), Expect = 1e-83, Method: Compositional matrix adjust.
Identities = 215/638 (33%), Positives = 314/638 (49%), Gaps = 41/638 (6%)
Query: 4 FIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVN-PYIVHSGYEIQLEWQRSK 62
F + A Y SYGPCQ PTLGF V+R L I F+ E FW++N + + + Q W+R +
Sbjct: 225 FQGITADYISYGPCQFPTLGFVVKRDLIIKNFESESFWTLNCTHDMGEEGKAQFLWKRGR 284
Query: 63 LFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
LFD + +L E V + +K+ K RP LNT+ L K+AS L G H M+
Sbjct: 285 LFDQLTCLVIYELCVEAQRARVVNVEKKRRYKYRPDPLNTIELQKLASQKLKMGSHETMK 344
Query: 123 LAERLYTQGFISYPRTESTAYPP--SFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLG 180
+AE LY +GFISYPRTE+ Y D + ++ +NPTWG Y LL GY KP G
Sbjct: 345 VAESLYNKGFISYPRTETNNYNQFQDDDLKRLVNEHTSNPTWGGYASDLLNGGYQKPPSG 404
Query: 181 T-DVGDHPPITPMRPAAEDMLGNDAWK--LYQYICQHFIGTVSPDCKYARRKVEFSIGGE 237
D HPPI P++ D ND+ + LY+ I +HF+ S D A KV SI E
Sbjct: 405 KQDDKAHPPIHPLKG---DCNSNDSKEQALYELIARHFLACCSKDAVGAETKVIISIANE 461
Query: 238 SFHCTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESEL 297
F C+G V K F I + +DK+IP F GQ+ + + + G T PP +L+ES+L
Sbjct: 462 EFTCSGLMVEQKNFLEIWKYDRWSDKSIPVFNAGQEFIPTSLLMDHGETRPPPHLSESDL 521
Query: 298 ISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPD 357
IS M+ NGIGTDA++ HI I ER YV ++ G + T LG+ L++GY I +L P+
Sbjct: 522 ISAMDSNGIGTDATVAQHIKTIQERGYV-IKKGNRFEATNLGMALLQGYDLIGYELSTPN 580
Query: 358 IRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDS-- 415
+RS +E+ + I+KG+ V+ + +K + K +D + F TL +
Sbjct: 581 LRSKMEKDMLSISKGEQSKEAVIHQSLSMYKHVYIQICKSAYLLDKAVQQHFPTLGEGQS 640
Query: 416 ---GRILSKCGKCLRYMKYISAQPSR-LYCGICEEVYYLPQKGTIKLYKELSCPLDNFEL 471
GR S C C M + L+C C + Y LP K + +++ CP+ NF++
Sbjct: 641 RVLGRGFSLCS-CKNPMDLKEQDGNNFLHCKNCSDSYPLPSKSEYESIEDV-CPICNFQI 698
Query: 472 LLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPN 531
L + S+ LCP+C++NPP I + S + G C C C
Sbjct: 699 LNI-ITQKNTSYKLCPHCFNNPP------EIENSNESFAN------GFKCFNCTFTGCKY 745
Query: 532 SLVSQGVC-ACPECSGTLVLDPVSAPK--WRLCCNMCNC--LVFLAQGAHRISTTKERCP 586
S V C +CS LV+ + C NC V+L + + T E+C
Sbjct: 746 SRKKDAVVRKCQKCSNNLVVRQRKNDTSLYIGCKGFPNCKSAVWLPKSIEKADLTTEKCN 805
Query: 587 ECDS---SIIEVDFN-KKATPLEDG-STLHRGCILCDE 619
C + ++ + F + T L G + H C+ CD+
Sbjct: 806 RCSTRSDTVYRLKFTFAQGTLLPPGVNREHTTCVFCDQ 843
>I7LXJ3_TETTS (tr|I7LXJ3) DNA topoisomerase OS=Tetrahymena thermophila (strain
SB210) GN=TTHERM_00464990 PE=3 SV=1
Length = 858
Score = 316 bits (809), Expect = 3e-83, Method: Compositional matrix adjust.
Identities = 172/407 (42%), Positives = 240/407 (58%), Gaps = 9/407 (2%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMF 72
SYGPCQTPTL FCV+R+ +I FKP+ +++V V+ +W + + FD A
Sbjct: 213 SYGPCQTPTLAFCVERHDEIENFKPQTYYTVE---VNLSEYATAKWSKEQTFDQEEAKKV 269
Query: 73 QKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGF 132
V + L V IS Q KSRPVGLNTVN+L++AS GPH A+ +AE LY GF
Sbjct: 270 LSEVQQSNQLMVKSISTVQAIKSRPVGLNTVNMLRIASKKYEIGPHDAIHIAESLYLLGF 329
Query: 133 ISYPRTESTAYPPSFDFRGALSAQANNP--TWGNYVEGLLTNGYLKPRLGTDVGDHPPIT 190
I+YPRTE+T YP FDF+ L A +N+ NY +GLL+ KP G D GDHPPIT
Sbjct: 330 ITYPRTETTKYPGEFDFKSVLHAISNSKFNNMANYAKGLLSEPLNKPYKGVDSGDHPPIT 389
Query: 191 PMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKG 250
P + A + L K+Y+ +C++F+G++S D + S G F ++ G
Sbjct: 390 PTQNAPQS-LNPQQMKIYELVCKNFLGSLSQDAQIENTTYILSSGQNEFEMKKSILLHSG 448
Query: 251 FTAIMPWLAI--NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGT 308
+ I+PW ++ ++ I +G I+ + E+ T PP YL+ES+LI LME+NGIGT
Sbjct: 449 YLDIVPWESVCLSNPKIEKIEEGVAIKYEQAEVLTLLTQPPSYLSESDLIGLMEQNGIGT 508
Query: 309 DASIPVHINNICERNYVQVQ-AGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
DAS+P HINNI RNYV V R+L+PT LGI L+ Y+ ID L P++R +E+QI+
Sbjct: 509 DASMPQHINNIILRNYVYVNIKERQLIPTQLGIALIHAYKDIDNQLVAPELRRNMEEQIS 568
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVD 414
IAKGQ+ +V+ I+ FKQK+ FV + +D F+ S L D
Sbjct: 569 QIAKGQMTKDELVETQIKIFKQKYENFVSQSNRLDFHFDLIKSFLQD 615
>F0XY93_AURAN (tr|F0XY93) DNA topoisomerase (Fragment) OS=Aureococcus
anophagefferens GN=AURANDRAFT_19616 PE=3 SV=1
Length = 696
Score = 315 bits (806), Expect = 5e-83, Method: Compositional matrix adjust.
Identities = 189/501 (37%), Positives = 271/501 (54%), Gaps = 19/501 (3%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDI 66
L A SYGPCQTPTLGF V+R +I TF+PE +W + + G W R + FD
Sbjct: 197 LDARTLSYGPCQTPTLGFVVRREDEIATFEPEPYWFPDAALEVDGAFADATWARGRCFDR 256
Query: 67 NVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAER 126
+VA + A G+ V E + TK+ P+ NTV+LLK AS L P MAM+ AE
Sbjct: 257 SVAAALCRGAAAAGVATVVESTAGTSTKAPPLPFNTVDLLKAASRVLRLSPAMAMKHAEH 316
Query: 127 LYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLL-TNGYLKPRLGTDVGD 185
LY GF+SYPRTE+ +PPS D R A+ QA + WG + LL + + +P+ G D GD
Sbjct: 317 LYLDGFLSYPRTETNKFPPSMDLRAAIEQQAGDARWGAHAADLLERSAWRRPKRGLDAGD 376
Query: 186 HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQH 245
HPPITP PA +L A LY + + F+ +VS D YA ++V + GE F +
Sbjct: 377 HPPITPTAPAPPGVLNGKAAALYDLVTRRFLASVSEDAAYADQRVAVDLAGERFVVERRA 436
Query: 246 VITKGFTAIMPWLAINDKNIPSFIK----GQKIEVS-KVELYEGTTTPPDYLTESELISL 300
++ GF ++ +D P F++ G + E TT PP+ L+E++ ++L
Sbjct: 437 LVAPGFLDVLRPHRDDDAGPPLFLELPAVGARPRAKCAAAPREATTRPPERLSEADCVAL 496
Query: 301 MEKNGIGTDASIPVHINNICERNYVQVQA-GRKLVPTTLGITLVRGYQSIDPDLCLPDIR 359
MEK+GIGTDASIP HI N+C+R YV V R+L PT LG + RG+ +D L LP++R
Sbjct: 497 MEKHGIGTDASIPSHIENVCKRLYVAVDGKSRRLRPTELGTVVCRGFLRVDASLVLPEVR 556
Query: 360 SFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTL--VDSGR 417
+ IE LIA G+ VV H + F K+ + ++AM+ LF+A ++ D+ R
Sbjct: 557 AAIEAACDLIAGGEAPREAVVAHCVANFAAKYAHLAAHVDAMEQLFDAVYAERPEDDASR 616
Query: 418 -ILSKCGKCLRYMKYISAQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSM 476
S+CG Y+ ++ +P RLY ++V LP+ G++ CP ELL +
Sbjct: 617 SAFSRCGLTGHYL-HLVPRPQRLYDPATKDVVDLPRPGSVAASNGRRCPACRSELLWYGL 675
Query: 477 GPDG-------KSFPLCPYCY 490
DG ++PLC CY
Sbjct: 676 R-DGAGDAAKTATYPLCGACY 695
>I7LVW6_TETTS (tr|I7LVW6) DNA topoisomerase OS=Tetrahymena thermophila (strain
SB210) GN=TTHERM_00216140 PE=3 SV=1
Length = 1049
Score = 312 bits (799), Expect = 3e-82, Method: Compositional matrix adjust.
Identities = 208/620 (33%), Positives = 305/620 (49%), Gaps = 40/620 (6%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIV----HSGYEIQLEWQRSKLFDINV 68
SYGPCQ PTLGF V RY QI F+ EKFW + P + + L+W R +LFD +
Sbjct: 196 SYGPCQFPTLGFVVDRYNQILKFQDEKFWYIQPSYQWKDNNKTLTVDLKWSRGRLFDQAI 255
Query: 69 ATMF--QKLVAEDGLLE----VTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQ 122
A++F EDG + V + +E+ TK RP L TV+L K L M
Sbjct: 256 ASVFYLNCTQNEDGEYDPKGIVVKKNERDTTKIRPYPLTTVDLTKQGCRILRMASEKIMH 315
Query: 123 LAERLYTQGFISYPRTESTAYPPSFD---FRGALSAQANNPTWGNYVEGLLTNG-YLKPR 178
AE+LY G+ISYPRTE+ YP +F + Q + WG Y L+ G + +PR
Sbjct: 316 TAEQLYQSGYISYPRTETNKYPDTFQNGQLMDLVRNQKQSDEWGFYSSNLIDQGNFQRPR 375
Query: 179 LGT-DVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGE 237
G D HPPI P++ A ++ L + WK+Y++I +HF+ + D A+ +VE E
Sbjct: 376 AGKQDDKAHPPIHPIKLANKNQLKPEEWKVYEFITRHFLASCGKDAVGAKTEVEVKFNDE 435
Query: 238 SFHCTGQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESEL 297
SF+ G V K + I + ND +P GQ I K+ L EG TTPP LTESEL
Sbjct: 436 SFNIDGLVVKEKNYLEIWTYEKWNDSIVPPLQPGQVIIPQKILLQEGKTTPPKPLTESEL 495
Query: 298 ISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPD 357
I +M KNGIGTDA++ HI I +R Y PT LG+ L Y + L PD
Sbjct: 496 IDMMNKNGIGTDATMHDHILTIQKRGYAVKNQHLMFTPTPLGLALCHAYDQLGLTLSKPD 555
Query: 358 IRSFIEQQITLIAKGQIDHHRVVQHVIQQFK-------QKFCYFVKKIEAMDALFEAQFS 410
+R+ +E+ ++ +A+G+ ++ ++++ K Q F+K + E S
Sbjct: 556 LRAKMERLMSDVAEGKTTREAIITQIMEEMKSIYKTVEQNKQLFIKSVGEQLKEQENSAS 615
Query: 411 TLVDSG-RILSKCGKCLRYMKYISAQPSR-LYCGICEEVYYLPQKGTIKLYKELSCPLDN 468
TL +S + S+CGKC + M+ + R L C C + Y +P+ G + E CPL N
Sbjct: 616 TLNNSNIQPGSECGKCQKIMELQTNDYQRQLVCNPCNKSYSIPKNGNLNFRNE-RCPLCN 674
Query: 469 FELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPT 528
F++L + G S+ +CP CY+NPP+ E I + ++ K MPC C +
Sbjct: 675 FQVLEVTTDK-GISYNICPSCYNNPPY---EQDIENSNANSEDSNFKKTSMPCYKCINKN 730
Query: 529 CPNS--LVSQGVCACPECSGTLVLDPVSAPKWRL--CCNM--CNCLVFLAQGAHRISTTK 582
C S L + + CP C+ + + K + C C+ VFL + +I T
Sbjct: 731 CSLSGGLKNISLYNCPCCNSPIQIRETKKDKKQFIGCTKYPDCDWSVFLPKDILQIFPTS 790
Query: 583 ERCPEC-----DSSIIEVDF 597
+ C C S ++EV F
Sbjct: 791 QECQSCKENNRKSLLVEVKF 810
>D7FUP7_ECTSI (tr|D7FUP7) DNA topoisomerase OS=Ectocarpus siliculosus
GN=Esi_0276_0016 PE=3 SV=1
Length = 759
Score = 312 bits (799), Expect = 3e-82, Method: Compositional matrix adjust.
Identities = 212/643 (32%), Positives = 304/643 (47%), Gaps = 61/643 (9%)
Query: 4 FIVLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSV-------NPYIVHSGYEIQL 56
F L SYGPCQ PTLGF V RY +I F+ E FWS+ +P
Sbjct: 5 FDELQEGVISYGPCQFPTLGFIVDRYKRIQAFQSEAFWSIKMEYAEDDPRSPGGKARADF 64
Query: 57 EWQRSKLFDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFG 116
WQR +L+D + ++ EDG+ VT + ++ TK+RP+ ++TV L K AS
Sbjct: 65 SWQRGRLYDHACCAILYEMTVEDGVAVVTSVEARRVTKARPIPMSTVELQKRASRFCHIS 124
Query: 117 PHMAMQLAERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNG-YL 175
M +AE LY +G ISYPRTE+ + FD L +NP +GNYV GLL NG +L
Sbjct: 125 SERTMHVAEALYQRGIISYPRTETEKFKREFDINTLLGDFRDNPRFGNYVGGLLDNGGFL 184
Query: 176 KPRLGT-DVGDHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSI 234
PR G D HPPI P + + L D K+Y+ + +HF+ S D + KV +
Sbjct: 185 WPREGRGDDSAHPPIHPTKSVDPNSLQADEKKIYELVTKHFLACCSKDAVGHQTKVLANC 244
Query: 235 GGESFHCTGQHVITKGFTAIM-PWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLT 293
GGE F TG V + + + P+ +NIP F +GQ+ S + + EG T P L+
Sbjct: 245 GGEDFTATGLMVTERNWLDVYEPFERWTGRNIPEFFQGQEFVPSVLVMDEGRTQAPPLLS 304
Query: 294 ESELISLMEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDL 353
ES+LI LM++ GIGTDA+I HI I +R Y + PTTLG+ LV GY +I +
Sbjct: 305 ESDLIGLMDQKGIGTDATIAEHIQKIQQRKYAVKNEQDRFYPTTLGLALVDGYDNIGFQM 364
Query: 354 CLPDIRSFIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF---- 409
P +R+ +E T I++G+ VV+ I + K+ F +D F
Sbjct: 365 SAPTLRAAMELDCTRISRGEDTKEAVVERCISKMKECFQTCQALAHKLDDAVAMHFRPLG 424
Query: 410 -----STLVDSGRILSKCGKCLRYMKYISAQPSR--LYCGICEEVYYLPQKGTI-KLYKE 461
S V GR S+CG C M + R L+CG+C+ + LP KG + K E
Sbjct: 425 SSGGESRTVRGGRGFSRCGVCGTAMDLKKSSSGRPLLFCGVCDTGFPLPHKGKLTKQDPE 484
Query: 462 LSCPLDNFE-------LLLCSMGPD--GKSFPLCPYCYSNPPFEGIEALINTAKTSTSGK 512
CPL +F+ +L S G D G + +CPYC++N P + G
Sbjct: 485 FECPLCHFQARFLHVLVLSVSTGNDYTGSGYTVCPYCFNNAP-------------AAHGG 531
Query: 513 IGKGAGMPCILCPHPTCPNSLVSQG------VCACPECSGTLVLDPVSAPKWRLCCN--- 563
G+ + C +C +CP + QG C C L + K+ L C
Sbjct: 532 EGQ-SQFRCFMC-SASCPLAKRVQGGDTTIVRCWKAGCGQALNIKRTRTGKYHLGCKGYP 589
Query: 564 MCN-CLVFLAQGAHRISTTKERCPECD-----SSIIEVDFNKK 600
C+ V+L + A +S T+E C C ++ +DF K
Sbjct: 590 ACSESTVWLPKNATNVSVTEETCARCSGPTAADAVRRLDFTFK 632
>M5XGT8_PRUPE (tr|M5XGT8) Uncharacterized protein OS=Prunus persica
GN=PRUPE_ppa015972mg PE=4 SV=1
Length = 254
Score = 310 bits (793), Expect = 2e-81, Method: Compositional matrix adjust.
Identities = 146/204 (71%), Positives = 162/204 (79%), Gaps = 20/204 (9%)
Query: 24 FCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFDINVATMFQKLVAEDGLLE 83
FCVQRYLQINTFKPEKFW+V PYI+ GYE+QLEW+R+KLFD +VA MFQKLV EDG+LE
Sbjct: 71 FCVQRYLQINTFKPEKFWAVRPYIIQKGYELQLEWERNKLFDYDVAVMFQKLVMEDGILE 130
Query: 84 VTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQGFISYPRTESTAY 143
VTE+ EKQE+KSRP GLNTVNLLKVASSAL SYPRTESTAY
Sbjct: 131 VTEMVEKQESKSRPFGLNTVNLLKVASSAL--------------------SYPRTESTAY 170
Query: 144 PPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAEDMLGND 203
P SFDFRG L AQ NNPTW +YV+ LL +GY KPR GTDVGDHPP+TP+R A EDMLGND
Sbjct: 171 PSSFDFRGTLRAQVNNPTWASYVQRLLADGYQKPRSGTDVGDHPPVTPLRSATEDMLGND 230
Query: 204 AWKLYQYICQHFIGTVSPDCKYAR 227
A +LY+YIC HFIGTVSPDCKY R
Sbjct: 231 AGRLYEYICTHFIGTVSPDCKYVR 254
>B3KU89_HUMAN (tr|B3KU89) cDNA FLJ39376 fis, clone PERIC1000025, highly similar
to DNA topoisomerase 3-beta-1 OS=Homo sapiens PE=2 SV=1
Length = 275
Score = 309 bits (791), Expect = 3e-81, Method: Compositional matrix adjust.
Identities = 144/246 (58%), Positives = 187/246 (76%), Gaps = 1/246 (0%)
Query: 255 MPWLAIN-DKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIP 313
MPW ++ ++++P+ +G V +V++ E T PPDYLTE+ELI+LMEK+GIGTDASIP
Sbjct: 1 MPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIP 60
Query: 314 VHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQ 373
VHINNIC+RNYV V++GR+L PT LGI LV GY ID +L LP IRS +E+Q+ LIA+G+
Sbjct: 61 VHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGK 120
Query: 374 IDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILSKCGKCLRYMKYIS 433
D+ +V+ H + FK+KF YFV I MD L E FS L +G+ LS+CGKC R+MKYI
Sbjct: 121 ADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQ 180
Query: 434 AQPSRLYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDGKSFPLCPYCYSNP 493
A+PSRL+C C+E Y LPQ GTIKLYKEL CPLD+FEL+L S G GKS+PLCPYCY++P
Sbjct: 181 AKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHP 240
Query: 494 PFEGIE 499
PF ++
Sbjct: 241 PFRDMK 246
>D3BRX9_POLPA (tr|D3BRX9) Ribose-phosphate pyrophosphokinase OS=Polysphondylium
pallidum GN=top3 PE=3 SV=1
Length = 1103
Score = 305 bits (782), Expect = 3e-80, Method: Compositional matrix adjust.
Identities = 177/494 (35%), Positives = 262/494 (53%), Gaps = 16/494 (3%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVN-PYIVHSGYEIQ---LEWQRSKLFDIN 67
SYGPCQ PTLGF V+R L+I F PE FW ++ + + E++ W+R +LF++
Sbjct: 535 ISYGPCQFPTLGFVVERALRIERFVPEDFWVIDVSHQKKADGEMRTADFGWKRKRLFELA 594
Query: 68 VATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERL 127
A +F + ++ L V +++ K E + RPV L T+ L K+AS L M+LAE L
Sbjct: 595 PAFIFYEQCLDNPLATVVDVNVK-ENRYRPVPLTTIELQKLASKKLRISSDETMKLAEEL 653
Query: 128 YTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGT-DVGDH 186
Y +GFISYPRTE+ ++ P DF G + Q +N WG Y + LL G+++P+ G + H
Sbjct: 654 YNKGFISYPRTETDSFLPETDFMGLIRLQTDNQKWGGYAQSLLNGGFVRPKEGKHNDNSH 713
Query: 187 PPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
PPI P A + L LY++IC+ F+ S + Y + V I E+F TG +
Sbjct: 714 PPIHPT--GAANALSGKQANLYEFICRRFLACCSKESIYGQTTVTIDIADETFSATGSMM 771
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
I +G+ + P+ DK +P+++ G+ S++EL + T P L+E EL+S M+ N I
Sbjct: 772 IQQGYLEVYPYDKRYDKILPTYVVGETFTPSRLELNKSRTVAPKPLSEPELLSEMDNNKI 831
Query: 307 GTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQI 366
GTDA++ HI I +RNYV + +PT LG L+ GY S+ P +R+ IE +
Sbjct: 832 GTDATMAQHIKKIIDRNYVIKNEENRFIPTDLGKALIIGYDSMGFGFSKPALRAKIEADV 891
Query: 367 TLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRI----LSKC 422
IA G V++ IQQ+K F + D F F RI LSKC
Sbjct: 892 HKIATGNRKKEDVLKDTIQQYKTLFIQAREMSHMFDITFSNYFRPYGSQFRILQANLSKC 951
Query: 423 GKCLRYMKYISAQPSR--LYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDG 480
GKC + S +R L C C + LP+ G I Y + +CPL NF++L + G
Sbjct: 952 GKCNNKLDLKSTDDARRVLQCKTCLASHMLPKVGDIVPY-DGTCPLCNFQVLTIT-SESG 1009
Query: 481 KSFPLCPYCYSNPP 494
+ +CP C +NPP
Sbjct: 1010 FPYQVCPNCRNNPP 1023
>F4PXY0_DICFS (tr|F4PXY0) DNA topoisomerase III OS=Dictyostelium fasciculatum
(strain SH3) GN=top3 PE=3 SV=1
Length = 812
Score = 302 bits (774), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 182/524 (34%), Positives = 266/524 (50%), Gaps = 41/524 (7%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLE--WQRSKLFDINVAT 70
SYGPCQ PTLGF V+RYL+I F PE FWS+N + HS E+ + W+R +LFD A
Sbjct: 238 SYGPCQFPTLGFVVERYLRIENFIPEDFWSMN--VKHSKEELTVNFGWKRKRLFDHAPAF 295
Query: 71 MFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYTQ 130
+ + ++ L V +I +K K L K ASS L M++AE LY +
Sbjct: 296 ILYEKCLDNPLATVIDIQKKNHNK----------LQKSASSKLRISSDRTMKIAEELYNK 345
Query: 131 GFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLG-TDVGDHPPI 189
GFISYPRTE++ + DF+G + Q +P WG Y LL + +P G T+ HPPI
Sbjct: 346 GFISYPRTETSQFIDGTDFQGLIGLQTGDPQWGQYATRLLNGEFKRPNDGRTNDHSHPPI 405
Query: 190 TP---MRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHV 246
P + P A A +LY++I +HF+ SP+ A+ V + GE F +G +
Sbjct: 406 HPTNFLPPGAAGAKDPKARELYEFIVRHFLACCSPESIIAKTTVSIDVAGEKFSESGSMI 465
Query: 247 ITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGI 306
I +G+ + + NDK IP++ G++ + ++L G T P L+E EL+S M+ N I
Sbjct: 466 IRRGYLEVYKYEKRNDKIIPTYEVGEQFTPTDIKLESGRTVSPRPLSEPELLSAMDSNQI 525
Query: 307 GTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQI 366
GTDA++ HI I ER YV A + VPT LG L+ GY S+ + P +R+ IE I
Sbjct: 526 GTDATMAQHIQKIIERGYVIKDADQLFVPTNLGKALIVGYDSMGFEFSKPALRASIEADI 585
Query: 367 TLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRIL----SKC 422
I GQ +V++ I+++K F + + +D F F++ + + L SKC
Sbjct: 586 QKIGLGQRTKEQVLRDTIEKYKTLFIQAQNQTQMLDVAFSKHFASKGQTYQTLKANFSKC 645
Query: 423 GKCLRYMKYISAQPSR--LYCGICEEVYYLPQKGTIKLYKELSCPLDNFELLLCSMGPDG 480
GKC M R L C C Y LPQKG + +CPL F+++ S+ D
Sbjct: 646 GKCNNLMDLKKTNGDRKILNCSTCNTSYNLPQKGEF-IVNAHTCPLCKFQVV--SVQTDK 702
Query: 481 KSFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILC 524
++ +CP+C ++PP S K G G C C
Sbjct: 703 TTYTICPFCRNHPP--------------ASSKEGPGKPFHCFQC 732
>B1H2R2_XENTR (tr|B1H2R2) DNA topoisomerase OS=Xenopus tropicalis GN=top3b PE=2
SV=1
Length = 482
Score = 299 bits (766), Expect = 2e-78, Method: Compositional matrix adjust.
Identities = 146/289 (50%), Positives = 190/289 (65%), Gaps = 4/289 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W V V G E + L+W R ++F
Sbjct: 194 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYW-VLQVKVSRGQENPLILDWDRVRVF 252
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + +V +S+K++ K RP LNTV +L+VASSALG GP MQ+A
Sbjct: 253 DREIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQIA 312
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G L QANNP W + V+ LL G +PR GTD G
Sbjct: 313 ERLYTQGYISYPRTETTHYPENFDLKGTLRQQANNPFWADMVKTLLAEGINRPRKGTDAG 372
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPMR A E LG DAW+LY+YI +HFI T+S DCKY + + FS+G E F T +
Sbjct: 373 DHPPITPMRSATEAELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEKFTTTCK 432
Query: 245 HVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYL 292
VI+ GFT IMPW I +++ +G K V +++L E T P L
Sbjct: 433 EVISPGFTEIMPWQGIPKEESFQPCERGDKFSVDEMKLMEKTDMPSRLL 481
>H1UBJ8_CAEEL (tr|H1UBJ8) Protein Y48C3A.14, isoform b OS=Caenorhabditis elegans
GN=CELE_Y48C3A.14 PE=3 SV=1
Length = 364
Score = 295 bits (756), Expect = 4e-77, Method: Compositional matrix adjust.
Identities = 152/330 (46%), Positives = 212/330 (64%), Gaps = 28/330 (8%)
Query: 301 MEKNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRS 360
MEK+GIGTDASIPVHIN I +RNYV V++GR+LVPT LG LVRGY +DP+L LP +R+
Sbjct: 1 MEKHGIGTDASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRA 60
Query: 361 FIEQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRILS 420
+E+Q+ L+A G+ D+ V H ++ F+ KF YFV I A+D LFEA F+TL D+G+ S
Sbjct: 61 ELEEQLNLVASGKADYLDVKNHALKMFEMKFQYFVTNIPAVDTLFEASFTTLSDTGKPFS 120
Query: 421 KCGKCLRYMKYISAQPSRLYCGICEEVYYLP--QKGTIKLYKELSCPLDNFELLLCSMGP 478
+CGKC RYMK + +P RLYC C+E Y +P + G +K+ + CPLD+F+++L GP
Sbjct: 121 RCGKCRRYMKLVQTKPQRLYCPTCQETYAVPNFKDGVLKVIGDHKCPLDDFDVIL-YQGP 179
Query: 479 DGK---SFPLCPYCYSNPPFEGIEALINTAKTSTSGKIGKGAGMPCILCPHPTCPNSLVS 535
GK +F LCP+C++NPPFE K+ +GAG C C HP+C S+ S
Sbjct: 180 GGKLARTFTLCPFCFNNPPFE---------------KMPQGAG--CDTCVHPSCQYSISS 222
Query: 536 QGVCAC-PECSGTLVLDPVSAPKWRLCCNMCNCLVFLAQGAHRISTTKER-CPECDSSII 593
GVC C +C G ++LD S PKWR+ CN C +V L +GA ++ R C +CD+ I
Sbjct: 223 NGVCGCLQDCGGVMLLDTQSHPKWRMTCNKCPSVVGLFEGAIKVKVDSTRSCEQCDAQFI 282
Query: 594 EVDF---NKKATPLEDGSTLHRGCILCDEL 620
+ +F + K +E S+ + GCI CD +
Sbjct: 283 KAEFKPNSGKPGAIEYESSSYEGCIFCDAM 312
>F7C5J9_XENTR (tr|F7C5J9) DNA topoisomerase OS=Xenopus tropicalis GN=top3b PE=3
SV=1
Length = 483
Score = 295 bits (755), Expect = 4e-77, Method: Compositional matrix adjust.
Identities = 143/280 (51%), Positives = 187/280 (66%), Gaps = 4/280 (1%)
Query: 7 LIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLF 64
L + S+GPCQTPTLGFCV+R+ +I +FKPE +W V V G E + L+W R ++F
Sbjct: 196 LDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYW-VLQVKVSRGQENPLILDWDRVRVF 254
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D +A MF + +V +S+K++ K RP LNTV +L+VASSALG GP MQ+A
Sbjct: 255 DREIAQMFINITKTAKEAQVESVSKKEKAKQRPQALNTVEMLRVASSALGMGPQHTMQIA 314
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
ERLYTQG+ISYPRTE+T YP +FD +G L QANNP W + V+ LL G +PR GTD G
Sbjct: 315 ERLYTQGYISYPRTETTHYPENFDLKGTLRQQANNPFWADMVKTLLAEGINRPRKGTDAG 374
Query: 185 DHPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
DHPPITPMR A E LG DAW+LY+YI +HFI T+S DCKY + + FS+G E F T +
Sbjct: 375 DHPPITPMRSATEAELGGDAWRLYEYITRHFIATISHDCKYLQTSIAFSVGPEKFTTTCK 434
Query: 245 HVITKGFTAIMPWLAI-NDKNIPSFIKGQKIEVSKVELYE 283
VI+ GFT IMPW I +++ +G K V +++L E
Sbjct: 435 EVISPGFTEIMPWQGIPKEESFQPCERGDKFSVDEMKLME 474
>F0ZSL6_DICPU (tr|F0ZSL6) Putative uncharacterized protein OS=Dictyostelium
purpureum GN=DICPUDRAFT_37309 PE=3 SV=1
Length = 831
Score = 291 bits (745), Expect = 7e-76, Method: Compositional matrix adjust.
Identities = 180/540 (33%), Positives = 271/540 (50%), Gaps = 35/540 (6%)
Query: 13 SYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHS--------GYEIQLEWQRSKLF 64
SYGPCQ PTLGF V+RY + F E FW+VN Y E+ W+R +LF
Sbjct: 215 SYGPCQFPTLGFVVERYFRKTNFVREDFWTVNVYDNRRIETNNDDRPSEVVFSWKRKRLF 274
Query: 65 DINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLA 124
D + A + + ++ V +I+ ++K RP+ L T+ L K AS L M +A
Sbjct: 275 DYSTAYILYEKCLDNPQAVVVDIN-TNDSKYRPLPLTTIELQKQASKKLRISSSDTMAIA 333
Query: 125 ERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVG 184
E LY +G ISYPRTE+ + DFRG + Q ++P WG Y + L + PR GT+
Sbjct: 334 EDLYNKGLISYPRTETDTFQQGTDFRGLIGIQGSHPQWGQYAQRLNNGEFKYPRSGTNND 393
Query: 185 D-HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTG 243
+ HPPI P A L + + K+Y++I + F+ S + V I GE F TG
Sbjct: 394 NSHPPIHPT-AACPSTLPDRSKKVYEFITRRFLACCSTESVLGNTSVTIEIEGEQFVETG 452
Query: 244 QHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEK 303
V G+ + P+ ++K IP + KG++ +V ++ELY GTT PP +LTESEL+S M+K
Sbjct: 453 VMVKEWGYLEVYPYDKRSNKTIPKYRKGERFQVKRIELYNGTTQPPHFLTESELLSAMDK 512
Query: 304 NGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIE 363
N IGTDA++ HI I +R YV + PT LGI+LV Y+ + P++R+ IE
Sbjct: 513 NKIGTDATMATHIQTIQDRGYVIKNQESQFEPTKLGISLVASYELMGFQFSKPELRAQIE 572
Query: 364 QQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGR------ 417
+ I+KG+ V++ I+++K+ F + + D F QF L +
Sbjct: 573 SDVNEISKGRKQKEEVLRTTIERYKELFEIAFQNTDCFDRSF-TQFYQLAEQRTNFHIEK 631
Query: 418 -ILSKCGKCLRYMKYISAQ----PSR-LYCGICEEVYYLPQKGTIKLYKELS-------- 463
L CGKC M + S + P R L C C++ + LP KG I E
Sbjct: 632 PQLVLCGKCNNKMDFKSDRNQETPKRILSCPTCKDSFDLPVKGEIGALTETDPLFNRTSP 691
Query: 464 --CPLDNFELLLCSMGPDGKSFPLCPYCYSNPPFEGIEALINTAK-TSTSGKIGKGAGMP 520
CPL +++++ ++ +CP C + PPF + + + T+T + KG P
Sbjct: 692 KLCPLCSYQVVTVYNQEKDYTYTICPKCRNKPPFPDKQKPFHCFQCTNTDCSLAKGKTTP 751
>A9YJ49_DROME (tr|A9YJ49) Topoisomerase 3 beta (Fragment) OS=Drosophila
melanogaster GN=CG3458 PE=3 SV=1
Length = 266
Score = 282 bits (722), Expect = 3e-73, Method: Compositional matrix adjust.
Identities = 134/267 (50%), Positives = 179/267 (67%), Gaps = 2/267 (0%)
Query: 139 ESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAED 198
E+ YP +FD L + +G +L + PR G D GDHPPITPM+
Sbjct: 1 ETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPPITPMKLGNRS 59
Query: 199 MLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWL 258
D W++Y++IC+HF+GTVS D KY + S+G E+F CT +I GFT +M W
Sbjct: 60 DFDRDTWRVYEFICRHFMGTVSKDLKYRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWS 119
Query: 259 AI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHIN 317
A D+ P F++G ++ ++ V L E T PPDYLTESELI+LME++GIGTDASIPVHIN
Sbjct: 120 AFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 179
Query: 318 NICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHH 377
NIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L LP +R+ +E+ +TLIA+G +
Sbjct: 180 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQ 239
Query: 378 RVVQHVIQQFKQKFCYFVKKIEAMDAL 404
V++H I+ FK KF YFVK I++MDAL
Sbjct: 240 DVLRHAIKIFKLKFMYFVKNIDSMDAL 266
>A9YJ44_DROME (tr|A9YJ44) CG3458 (Fragment) OS=Drosophila melanogaster GN=CG3458
PE=3 SV=1
Length = 266
Score = 282 bits (721), Expect = 3e-73, Method: Compositional matrix adjust.
Identities = 134/267 (50%), Positives = 179/267 (67%), Gaps = 2/267 (0%)
Query: 139 ESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGDHPPITPMRPAAED 198
E+ YP +FD L + +G +L + PR G D GDHPPITPM+
Sbjct: 1 ETNQYPTNFDLPAVLHVLKPSADFGEEARSILGD-IQTPRKGKDAGDHPPITPMKLGNRS 59
Query: 199 MLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVITKGFTAIMPWL 258
D W++Y++IC+HF+GTVS D KY + S+G E+F CT +I GFT +M W
Sbjct: 60 DFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWS 119
Query: 259 AI-NDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIGTDASIPVHIN 317
A D+ P F++G ++ ++ V L E T PPDYLTESELI+LME++GIGTDASIPVHIN
Sbjct: 120 AFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHIN 179
Query: 318 NICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQITLIAKGQIDHH 377
NIC+RNYV ++ GRKL+PTTLGI LV GYQ IDP+L LP +R+ +E+ +TLIA+G +
Sbjct: 180 NICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQ 239
Query: 378 RVVQHVIQQFKQKFCYFVKKIEAMDAL 404
V++H I+ FK KF YFVK I++MDAL
Sbjct: 240 DVLRHAIKIFKLKFMYFVKNIDSMDAL 266
>L8YCR4_TUPCH (tr|L8YCR4) DNA topoisomerase OS=Tupaia chinensis
GN=TREES_T100005658 PE=3 SV=1
Length = 967
Score = 282 bits (721), Expect = 4e-73, Method: Compositional matrix adjust.
Identities = 147/405 (36%), Positives = 221/405 (54%), Gaps = 3/405 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 213 VLTEQLISYGSCQFPTLGFVVERFKAIQAFVPETFHRIKVNHDHEDGIVEFNWKRHRLFN 272
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ L ED + V E+ K ++K RP L+TV L K+AS L M++AE
Sbjct: 273 HTACLVLYHLCMEDPMATVVEVKSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 332
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQGFISYPRTE+ +P + + Q +P WG + +L G PR G
Sbjct: 333 KLYTQGFISYPRTETNIFPKDLNLTALVDQQTQDPRWGAFARSILERGGPNPRNGNKSDQ 392
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + A+ L D +LY++I +HF+ S D + VE I E F G
Sbjct: 393 AHPPIHPTKYASN--LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 450
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 451 VILARNYLDVYPYDHWSDKLLPVYERGSRFQPSAVEMVDGETSPPQLLTEADLIALMEKH 510
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 511 GIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 570
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
+ LI +G+ D H V++ +Q++KQ F V K + +D F
Sbjct: 571 DLKLICEGKKDKHVVLRQQVQKYKQVFTEAVAKAKKLDEALSQYF 615
>Q4W5X0_CHICK (tr|Q4W5X0) DNA topoisomerase OS=Gallus gallus GN=TOP3A PE=2 SV=1
Length = 1020
Score = 281 bits (720), Expect = 5e-73, Method: Compositional matrix adjust.
Identities = 147/410 (35%), Positives = 226/410 (55%), Gaps = 3/410 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
+L SYG CQ PTLGF V+R+ I F PE F+ + H + W+R++LF+
Sbjct: 235 ILADQLISYGSCQFPTLGFVVERFKAIQAFVPEAFYKIKVTHDHEDGNVVFNWKRNRLFN 294
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ + ED + V E+ K ++K RP+ L+TV L K+AS L M++AE
Sbjct: 295 HTACLVLYHMCMEDPIATVVEVGSKPKSKWRPLPLDTVELEKLASRKLKINAKETMRIAE 354
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQGFISYPRTE+ +P + + Q +P WG + + +L G PR GT
Sbjct: 355 KLYTQGFISYPRTETNIFPKELNLSALVQHQTQDPNWGAFAQRILDQGGPTPRNGTKSDQ 414
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + A ++ GN+ +LY++I +HF+ S D K VE I E F G
Sbjct: 415 AHPPIHPTKYTA-NLQGNEQ-RLYEFIVRHFLACCSQDAKGQETTVEIDIANERFVAQGL 472
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK IP + KG + + + VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 473 MILARNYLEVYPYEKWSDKVIPLYQKGSRFQPTTVEMVDGETSPPLLLTEADLIALMEKH 532
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + A ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 533 GIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 592
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVD 414
+ LI +G+ D V+ +Q++KQ F V + +D F +
Sbjct: 593 DLKLICEGKKDKSIVLHQQVQKYKQVFIEAVARANKLDQALAQYFGEATE 642
>F1P1F3_CHICK (tr|F1P1F3) DNA topoisomerase OS=Gallus gallus GN=TOP3A PE=3 SV=1
Length = 1020
Score = 281 bits (720), Expect = 5e-73, Method: Compositional matrix adjust.
Identities = 147/410 (35%), Positives = 226/410 (55%), Gaps = 3/410 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
+L SYG CQ PTLGF V+R+ I F PE F+ + H + W+R++LF+
Sbjct: 235 ILADQLISYGSCQFPTLGFVVERFKAIQAFVPEAFYKIKVTHDHEDGNVVFNWKRNRLFN 294
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ + ED + V E+ K ++K RP+ L+TV L K+AS L M++AE
Sbjct: 295 HTACLVLYHMCMEDPVATVVEVGSKPKSKWRPLPLDTVELEKLASRKLKINAKETMRIAE 354
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQGFISYPRTE+ +P + + Q +P WG + + +L G PR GT
Sbjct: 355 KLYTQGFISYPRTETNIFPKELNLSALVQHQTQDPNWGAFAQRILDQGGPTPRNGTKSDQ 414
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + A ++ GN+ +LY++I +HF+ S D K VE I E F G
Sbjct: 415 AHPPIHPTKYTA-NLQGNEQ-RLYEFIVRHFLACCSQDAKGQETTVEIDIANERFVAQGL 472
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK IP + KG + + + VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 473 MILARNYLEVYPYEKWSDKVIPLYQKGSRFQPTTVEMVDGETSPPLLLTEADLIALMEKH 532
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + A ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 533 GIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 592
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVD 414
+ LI +G+ D V+ +Q++KQ F V + +D F +
Sbjct: 593 DLKLICEGKKDKSIVLHQQVQKYKQVFIEAVARANKLDQALAQYFGEATE 642
>H9GF12_ANOCA (tr|H9GF12) DNA topoisomerase OS=Anolis carolinensis GN=TOP3A PE=3
SV=2
Length = 997
Score = 281 bits (719), Expect = 7e-73, Method: Compositional matrix adjust.
Identities = 148/405 (36%), Positives = 226/405 (55%), Gaps = 3/405 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F E F+ + H + W+R++LF+
Sbjct: 237 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVAETFYKIKVTHDHEEGTVDFSWKRNRLFN 296
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED L V E+ + ++K RP+ L+TV L K+AS L M++AE
Sbjct: 297 HTACLILYQMCMEDPLATVVEVGSRPKSKWRPLPLDTVELEKLASRKLKINAKETMKIAE 356
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P + + Q +P WG + + +L G PR GT
Sbjct: 357 KLYTQGYISYPRTETNIFPKDLNLPNLVQLQTLDPRWGAFAQRILDQGGPTPRSGTKSDQ 416
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + A ++ GND +LY++I +HF+ S D K VE + E F G
Sbjct: 417 AHPPIHPTKHAT-NLQGNDQ-RLYEFIVRHFLACCSQDAKGQETTVEIDVANERFVAHGL 474
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK IP + KG + + S VE+ EG T+PP LTE++LISLMEK+
Sbjct: 475 MILARNYLEVYPYEKWSDKVIPVYEKGSRFQPSTVEMVEGETSPPQLLTEADLISLMEKH 534
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ VP LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 535 GIGTDATHAEHIETIKSRMYVGLTPDQRFVPGELGMGLVEGYDSMGYEMSKPDLRAELEH 594
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
+ LI +G+ V++ +Q++K+ F V+K + +D F
Sbjct: 595 DLKLICEGKKGKAVVLREQVQKYKRVFIEAVQKAKKLDEALAQYF 639
>K7GGN4_PELSI (tr|K7GGN4) DNA topoisomerase OS=Pelodiscus sinensis GN=TOP3A PE=3
SV=1
Length = 1016
Score = 280 bits (717), Expect = 1e-72, Method: Compositional matrix adjust.
Identities = 154/448 (34%), Positives = 235/448 (52%), Gaps = 13/448 (2%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F+ + H + W+R++LF+
Sbjct: 235 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEAFYKIKVTHEHEDGIVDFNWKRNRLFN 294
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED + V EI K ++K RPV L+TV L K+AS L M++AE
Sbjct: 295 HTACLVLYQMCMEDPVATVVEIGSKPKSKWRPVALDTVELEKLASRKLKINAKETMRVAE 354
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P + + Q N WG + + +L G PR GT
Sbjct: 355 KLYTQGYISYPRTETNIFPKDLNLTSLVQQQTQNINWGAFAQRILDQGGPTPRNGTKSDQ 414
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + D+ GN+ +LY++I +HF+ S D K VE I E F G
Sbjct: 415 AHPPIHPTKYTG-DLQGNEQ-RLYEFIVRHFLACCSQDAKGQETTVEIDIANERFVAHGL 472
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + + S VE+ +G T+PP LTE++LISLMEK+
Sbjct: 473 MILARNYLDVYPYEKWSDKVLPVYERGSRFQPSTVEMVDGETSPPQLLTEADLISLMEKH 532
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 533 GIGTDATHAEHIETIKSRMYVGLTPDQRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 592
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRI------ 418
+ LI +G+ D V++ + ++K F V K +D F + + +
Sbjct: 593 DLKLICEGKKDKSVVLRQQVAKYKHVFTEAVAKANKLDQALSQYFGEVTELAQQEEIYPA 652
Query: 419 ----LSKCGKCLRYMKYISAQPSRLYCG 442
+ KC +C M S + Y G
Sbjct: 653 MPVPIRKCPRCGSDMVLKSRKNGGFYLG 680
>K7GGM4_PELSI (tr|K7GGM4) DNA topoisomerase OS=Pelodiscus sinensis GN=TOP3A PE=3
SV=1
Length = 1038
Score = 280 bits (717), Expect = 1e-72, Method: Compositional matrix adjust.
Identities = 154/448 (34%), Positives = 235/448 (52%), Gaps = 13/448 (2%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F+ + H + W+R++LF+
Sbjct: 235 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEAFYKIKVTHEHEDGIVDFNWKRNRLFN 294
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED + V EI K ++K RPV L+TV L K+AS L M++AE
Sbjct: 295 HTACLVLYQMCMEDPVATVVEIGSKPKSKWRPVALDTVELEKLASRKLKINAKETMRVAE 354
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P + + Q N WG + + +L G PR GT
Sbjct: 355 KLYTQGYISYPRTETNIFPKDLNLTSLVQQQTQNINWGAFAQRILDQGGPTPRNGTKSDQ 414
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + D+ GN+ +LY++I +HF+ S D K VE I E F G
Sbjct: 415 AHPPIHPTKYTG-DLQGNEQ-RLYEFIVRHFLACCSQDAKGQETTVEIDIANERFVAHGL 472
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + + S VE+ +G T+PP LTE++LISLMEK+
Sbjct: 473 MILARNYLDVYPYEKWSDKVLPVYERGSRFQPSTVEMVDGETSPPQLLTEADLISLMEKH 532
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 533 GIGTDATHAEHIETIKSRMYVGLTPDQRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 592
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRI------ 418
+ LI +G+ D V++ + ++K F V K +D F + + +
Sbjct: 593 DLKLICEGKKDKSVVLRQQVAKYKHVFTEAVAKANKLDQALSQYFGEVTELAQQEEIYPA 652
Query: 419 ----LSKCGKCLRYMKYISAQPSRLYCG 442
+ KC +C M S + Y G
Sbjct: 653 MPVPIRKCPRCGSDMVLKSRKNGGFYLG 680
>Q6GPC0_XENLA (tr|Q6GPC0) DNA topoisomerase OS=Xenopus laevis GN=top3a PE=2 SV=1
Length = 1022
Score = 278 bits (711), Expect = 5e-72, Method: Compositional matrix adjust.
Identities = 146/411 (35%), Positives = 225/411 (54%), Gaps = 3/411 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F+ + H ++ W+R++LF+
Sbjct: 238 VLSNQLISYGSCQFPTLGFVVERFKAIQAFIPETFYKIKVTHEHEDGLVEFSWKRNRLFN 297
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED + V E+ K ++K RPV L+TV L K+AS L G M+ AE
Sbjct: 298 HTACLVLYQICMEDPMATVMEVGSKPKSKWRPVALDTVELEKLASRKLKIGAKETMKTAE 357
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQGFISYPRTE+ +P + + Q ++P WG + + +L G PR G
Sbjct: 358 KLYTQGFISYPRTETNIFPKDLNLTSLVEQQTHDPQWGGFAQRILERGGPTPRNGNKTDQ 417
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + ++ GN+ ++Y++I +HF+ S D + VE I E F G
Sbjct: 418 AHPPIHPTK-YTNNLQGNEQ-RIYEFIVRHFLACCSQDAQGQETTVEIDIAAERFVAHGL 475
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I + + + P+ N K IP + G + + + VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 476 MIIARNYLDVYPYDKWNTKIIPVYEMGAQFQPTTVEMVDGETSPPQLLTEADLIALMEKH 535
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R+YV + ++ +P LG+ LV GY S+ + PD+R+ +E
Sbjct: 536 GIGTDATHAEHIETIKSRSYVGLTPEQRFLPGELGMGLVEGYDSMGFQMSKPDLRAELES 595
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDS 415
+ LI +G+ D V++ IQ++KQ F K +D F ++
Sbjct: 596 DLKLICEGKKDKFTVLRLQIQKYKQVFVEAAAKATKLDEALSQYFGQAAEA 646
>G3SN49_LOXAF (tr|G3SN49) DNA topoisomerase OS=Loxodonta africana GN=TOP3A PE=3
SV=1
Length = 1008
Score = 278 bits (710), Expect = 6e-72, Method: Compositional matrix adjust.
Identities = 147/407 (36%), Positives = 223/407 (54%), Gaps = 5/407 (1%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKL 63
VL SYG CQ PTLGF V+R+ I F PE F + + H + ++ W+R +L
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPETFHRIKDIVTHEHEDGIVEFNWKRHRL 292
Query: 64 FDINVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQL 123
F+ + +L ED V E+ K ++K RP L+TV L K+AS L M++
Sbjct: 293 FNHTACLVLYQLCMEDPTATVVEVCSKPKSKWRPQALDTVELEKLASRKLRINAKETMRI 352
Query: 124 AERLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDV 183
AERLYTQG+ISYPRTE+ +P + + Q +P WG + + +L G PR G
Sbjct: 353 AERLYTQGYISYPRTETNIFPKDLNLTALVEQQIQDPRWGAFAQSILERGGPTPRNGNKS 412
Query: 184 GD-HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCT 242
HPPI P + + L D +LY++I +HF+ S + + VE I E F +
Sbjct: 413 DQAHPPIHPTKHTSN--LQGDEQRLYEFIVRHFLACCSQNAQGQETTVEIDIAQERFLAS 470
Query: 243 GQHVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLME 302
G V+ + + + P+ +DK IP + +G + S VE+ +G T+PP LTE++LI+LME
Sbjct: 471 GLMVLARNYLDVYPYDHWSDKIIPVYERGSSFQPSTVEMVDGETSPPQLLTEADLIALME 530
Query: 303 KNGIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFI 362
K+GIGTDA+ HI I R YV + A ++ +P LG+ LV GY S+ ++ PD+R+ +
Sbjct: 531 KHGIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAEL 590
Query: 363 EQQITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
E + LI +G+ D V++ +Q++KQ F V K + +D F
Sbjct: 591 EADLKLICEGKKDKCVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYF 637
>I3MP50_SPETR (tr|I3MP50) DNA topoisomerase OS=Spermophilus tridecemlineatus
GN=TOP3A PE=3 SV=1
Length = 1008
Score = 278 bits (710), Expect = 7e-72, Method: Compositional matrix adjust.
Identities = 151/435 (34%), Positives = 231/435 (53%), Gaps = 13/435 (2%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGTVEFNWKRHRLFN 292
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ +L ED L V EI K ++K RP L+TV L K+AS L M++AE
Sbjct: 293 HTACLVLYQLCMEDPLATVVEIRSKPKSKWRPQALDTVELEKLASRKLKINAKETMRIAE 352
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P + + Q +P WG + + +L G PR G
Sbjct: 353 KLYTQGYISYPRTETNIFPKDLNLMALVEQQTPDPHWGAFAQSILERGGPTPRNGNKSDQ 412
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + + L D +LY++I +HF+ S D + VE I E F G
Sbjct: 413 AHPPIHPTKYTSN--LQGDERRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 470
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 471 MILARNYLDVYPYDHWSDKLLPVYEQGSRFQPSTVEMVDGETSPPQLLTEADLIALMEKH 530
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 531 GIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 590
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSGRI------ 418
+ LI +G+ D V++ +Q++KQ F V K + +D F + +
Sbjct: 591 DLKLICEGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGAEVAQQEEIYPT 650
Query: 419 ----LSKCGKCLRYM 429
+ KC +C R M
Sbjct: 651 MPEPIQKCPQCNRDM 665
>E2RIS5_CANFA (tr|E2RIS5) DNA topoisomerase OS=Canis familiaris GN=TOP3A PE=3
SV=1
Length = 989
Score = 277 bits (709), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 146/405 (36%), Positives = 220/405 (54%), Gaps = 3/405 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHKIKVTHDHKDGIVEFNWKRHRLFN 292
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ +L ED V E+ K ++K RP L+TV L K+AS L M++AE
Sbjct: 293 HTACLVLYQLCMEDPTATVVEVRSKSKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P D + Q +P WG + + +L G PR G
Sbjct: 353 KLYTQGYISYPRTETNIFPKDLDLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQ 412
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + + L D +LY++I +HF+ S D + VE I E F G
Sbjct: 413 AHPPIHPTKYTSS--LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 470
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 471 MILARNYLDVYPYDRWSDKTLPVYERGSHFQPSTVEMVDGETSPPQLLTEADLIALMEKH 530
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + A ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 531 GIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 590
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
+ LI +G+ D V++ +Q++KQ F V K + +D F
Sbjct: 591 DLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYF 635
>G1SQY7_RABIT (tr|G1SQY7) DNA topoisomerase OS=Oryctolagus cuniculus PE=3 SV=1
Length = 993
Score = 276 bits (707), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 145/405 (35%), Positives = 222/405 (54%), Gaps = 3/405 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 234 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHRIKVTHAHRDGVVEFHWKRHRLFN 293
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ +L ED V E+ K ++K RP L+TV L K+AS L M++AE
Sbjct: 294 HTACLVLYQLCMEDPTATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 353
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P + + Q +P WG + + +L G PR G
Sbjct: 354 KLYTQGYISYPRTETNIFPKDLNLTALVEQQTQDPRWGAFAQSILERGGPSPRNGNKSDQ 413
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + A+ L D +LY++I +HF+ S D + VE +I E F G
Sbjct: 414 AHPPIHPTKYASS--LQGDDQRLYEFIVRHFLACCSQDAQGQETTVEINIAQERFVAHGL 471
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 472 VILARNYLDVYPYDHWSDKLLPIYEQGSRFQPSTVEMVDGETSPPQLLTEADLIALMEKH 531
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 532 GIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 591
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
+ LI +G+ D V++ +Q++KQ F V K + +D F
Sbjct: 592 DLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYF 636
>L5KY49_PTEAL (tr|L5KY49) DNA topoisomerase OS=Pteropus alecto
GN=PAL_GLEAN10008620 PE=3 SV=1
Length = 1007
Score = 276 bits (707), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 144/405 (35%), Positives = 222/405 (54%), Gaps = 3/405 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I +F PE F + H ++ W+R +LF+
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQSFVPEIFHKIKVTHDHRDGIVEFNWKRHRLFN 292
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ +L ED V E+S K ++K RP L+TV L K+AS L M++AE
Sbjct: 293 HTACLVLYQLCMEDPTATVVEVSSKAKSKWRPQALDTVELEKLASRKLKINAKETMRIAE 352
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P + + Q +P WG + + +L G PR G
Sbjct: 353 KLYTQGYISYPRTETNIFPRDLNLTALVEQQIPDPRWGAFAQSILERGVPTPRNGNKSDQ 412
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + + L + +LY++I +HF+ S D + VE I E F G
Sbjct: 413 AHPPIHPTKYTSS--LQGEEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 470
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 471 VILARNYLDVYPYDRWSDKTLPVYERGSRFQPSTVEMVDGETSPPQLLTEADLIALMEKH 530
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 531 GIGTDATHAEHIETIKARTYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 590
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
+ LI +G+ D V++ +Q++KQ F V K + +D F
Sbjct: 591 DLKLICEGKKDKFVVLRQQVQKYKQVFTEAVAKAKKLDEALSQYF 635
>F7A1S4_XENTR (tr|F7A1S4) DNA topoisomerase (Fragment) OS=Xenopus tropicalis
GN=top3a PE=3 SV=1
Length = 1021
Score = 276 bits (706), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 146/405 (36%), Positives = 222/405 (54%), Gaps = 3/405 (0%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F+ + H ++ W+R++LF+
Sbjct: 237 VLSNQLISYGSCQFPTLGFVVERFKAIQAFIPETFYKIKVTHEHEDGLVEFSWKRNRLFN 296
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED + V E+ K ++K RPV L+TV L K+AS L G M++AE
Sbjct: 297 HTACLVLYQICMEDPMATVMEVGSKPKSKWRPVALDTVELEKLASRKLKIGAKETMKVAE 356
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQGFISYPRTE+ +P + + Q ++ WG + + +L G PR G
Sbjct: 357 KLYTQGFISYPRTETNIFPKDLNLTSLVEQQTHDHQWGGFAQRILERGGPTPRNGNKTDQ 416
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + + GN+ ++Y++I +HF+ S D + VE I E F G
Sbjct: 417 AHPPIHPTK-YTNSLQGNEQ-RIYEFIVRHFLACCSQDAQGQETTVEIDIAAERFVAHGL 474
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I + + + P+ N K IP + G + + S VE+ +G T+PP LTE++LISLMEK+
Sbjct: 475 MIIARNYLDVYPYDKWNTKIIPVYEMGARFQPSTVEMVDGETSPPQLLTEADLISLMEKH 534
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 535 GIGTDATHAEHIETIKSRMYVGLTPEQRFLPGELGMGLVEGYDSMGFEMSKPDLRAELES 594
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQF 409
+ LI +G+ D V++ +Q++KQ F K +D F
Sbjct: 595 DLKLICEGKKDKFSVLRLQVQKYKQVFVEAAAKATKLDEALSQYF 639
>I3JP29_ORENI (tr|I3JP29) DNA topoisomerase OS=Oreochromis niloticus GN=top3a
PE=3 SV=1
Length = 1037
Score = 276 bits (705), Expect = 2e-71, Method: Compositional matrix adjust.
Identities = 145/395 (36%), Positives = 230/395 (58%), Gaps = 8/395 (2%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLFDINVA 69
SYG CQ PTLGF V+R+ I F PE F+ + ++H E + W+R++LF+
Sbjct: 256 ISYGSCQFPTLGFVVERFKAIQAFIPETFYKIK--VIHEVEEDCVDFNWKRNRLFNHTAC 313
Query: 70 TMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYT 129
+ ++ ED + VT ++ K ++K RP+ L+TV L K+AS L M++AE+LYT
Sbjct: 314 LVLYQICMEDPIATVTSVTSKPKSKWRPLPLDTVELEKLASRKLRISAKETMKIAEKLYT 373
Query: 130 QGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTN-GYLKPRLGTDVGD-HP 187
QGFISYPRTE+ +PP+ + Q ++P WG + + +L G PR G + HP
Sbjct: 374 QGFISYPRTETNIFPPNLALTPLVEQQTHSPVWGAFAQRVLDQPGGPNPRQGKNSDQAHP 433
Query: 188 PITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVI 247
PI P + + GN+ ++Y++I +HF+ VS D V+ I E F +G +I
Sbjct: 434 PIHPTK-FTNALQGNEG-RVYEFIVRHFLACVSQDALGQETVVDIDIAQEKFSASGLMII 491
Query: 248 TKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIG 307
+ + + P+ + K IP + +G + + S +E+ +G T+PP LTE++LISLMEK+GIG
Sbjct: 492 ARNYLDVYPYDRWSTKVIPVYEQGSQFQPSAIEMVDGQTSPPQLLTEADLISLMEKHGIG 551
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDA+ HI I R YV + A ++ P LG+ LV GY S+ ++ P++R+ +E +
Sbjct: 552 TDATHAEHIETIKSRMYVGLTADQRFTPGELGMGLVEGYNSMGYEMSKPNLRAELEADLK 611
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMD 402
L+++GQ D V+QH IQ++K F V+K + +D
Sbjct: 612 LVSEGQKDKQSVLQHHIQKYKTVFIESVRKAKKLD 646
>H3AKB8_LATCH (tr|H3AKB8) DNA topoisomerase OS=Latimeria chalumnae PE=3 SV=1
Length = 999
Score = 276 bits (705), Expect = 3e-71, Method: Compositional matrix adjust.
Identities = 149/435 (34%), Positives = 234/435 (53%), Gaps = 13/435 (2%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F+ + + W+R++LF+
Sbjct: 227 VLSDQLISYGSCQFPTLGFVVERFKAIQAFIPETFFKIKVTHESEDGTVDFNWKRNRLFN 286
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED + V +++ K ++K RP+ L+TV L K+AS L G M++AE
Sbjct: 287 HTACLVLYQICMEDPVATVIDVTSKPKSKWRPLPLDTVELEKLASRKLKIGAKETMKIAE 346
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +PP + + Q + WG + +G+L G PR G
Sbjct: 347 KLYTQGYISYPRTETNMFPPDLNLSSLVQQQTGDQRWGAFAQGILDRGGPTPRSGNKSDQ 406
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + + L + +LY++I +HF+ S D + VE I E F G
Sbjct: 407 AHPPIHPTK--YTNALQGNEQRLYEFIVRHFLACCSQDAQGQETIVEIDIAKERFVAHGL 464
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
+I + + + P+ N K IP + G + + + +E+ +G T+PP LTE++LISLMEK+
Sbjct: 465 MIIARNYLDVYPYDKWNAKVIPVYEMGSRFQPTTIEMLDGETSPPQLLTEADLISLMEKH 524
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 525 GIGTDATHAEHIETIKSRMYVGLTPEQRFLPGELGMGLVEGYDSMGYEMSKPDLRAELEA 584
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTL----------VD 414
+ LI++G+ D V++ +Q++KQ F V K + +D F ++
Sbjct: 585 DLKLISEGKKDKFTVLRQHVQKYKQVFVEAVAKAKKLDEALSLYFGEASQVTQIEEMQME 644
Query: 415 SGRILSKCGKCLRYM 429
R + KC +C R M
Sbjct: 645 IPRPVRKCPQCNRDM 659
>I3JP28_ORENI (tr|I3JP28) DNA topoisomerase (Fragment) OS=Oreochromis niloticus
GN=top3a PE=3 SV=1
Length = 1005
Score = 276 bits (705), Expect = 3e-71, Method: Compositional matrix adjust.
Identities = 145/395 (36%), Positives = 230/395 (58%), Gaps = 8/395 (2%)
Query: 12 FSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYE--IQLEWQRSKLFDINVA 69
SYG CQ PTLGF V+R+ I F PE F+ + ++H E + W+R++LF+
Sbjct: 238 ISYGSCQFPTLGFVVERFKAIQAFIPETFYKIK--VIHEVEEDCVDFNWKRNRLFNHTAC 295
Query: 70 TMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAERLYT 129
+ ++ ED + VT ++ K ++K RP+ L+TV L K+AS L M++AE+LYT
Sbjct: 296 LVLYQICMEDPIATVTSVTSKPKSKWRPLPLDTVELEKLASRKLRISAKETMKIAEKLYT 355
Query: 130 QGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTN-GYLKPRLGTDVGD-HP 187
QGFISYPRTE+ +PP+ + Q ++P WG + + +L G PR G + HP
Sbjct: 356 QGFISYPRTETNIFPPNLALTPLVEQQTHSPVWGAFAQRVLDQPGGPNPRQGKNSDQAHP 415
Query: 188 PITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQHVI 247
PI P + + GN+ ++Y++I +HF+ VS D V+ I E F +G +I
Sbjct: 416 PIHPTK-FTNALQGNEG-RVYEFIVRHFLACVSQDALGQETVVDIDIAQEKFSASGLMII 473
Query: 248 TKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKNGIG 307
+ + + P+ + K IP + +G + + S +E+ +G T+PP LTE++LISLMEK+GIG
Sbjct: 474 ARNYLDVYPYDRWSTKVIPVYEQGSQFQPSAIEMVDGQTSPPQLLTEADLISLMEKHGIG 533
Query: 308 TDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQQIT 367
TDA+ HI I R YV + A ++ P LG+ LV GY S+ ++ P++R+ +E +
Sbjct: 534 TDATHAEHIETIKSRMYVGLTADQRFTPGELGMGLVEGYNSMGYEMSKPNLRAELEADLK 593
Query: 368 LIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMD 402
L+++GQ D V+QH IQ++K F V+K + +D
Sbjct: 594 LVSEGQKDKQSVLQHHIQKYKTVFIESVRKAKKLD 628
>L8J1J2_BOSMU (tr|L8J1J2) DNA topoisomerase OS=Bos grunniens mutus GN=M91_01740
PE=3 SV=1
Length = 1002
Score = 275 bits (704), Expect = 3e-71, Method: Compositional matrix adjust.
Identities = 157/477 (32%), Positives = 239/477 (50%), Gaps = 19/477 (3%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIRVTHDHRDGVVEFSWKRHRLFN 292
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED V E+ K ++K RP L+TV L K+AS L M++AE
Sbjct: 293 HTACLVLYQMCMEDPRATVVEVRSKAKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P D + Q +P WG + +L G PR G
Sbjct: 353 KLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGPTPRNGNKSDQ 412
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + D L D +LY+ I +HF+ S D + VE I E F G
Sbjct: 413 AHPPIHPTK--YTDSLQGDEQRLYELIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 470
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 471 MILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEADLIALMEKH 530
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 531 GIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 590
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSG-------- 416
+ LI +G+ D V+ +Q++KQ F V K +D F +
Sbjct: 591 DLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAATEVAPQDALPAV 650
Query: 417 -RILSKCGKCLRYMKYISAQPSRLYCGI-----CEEVYYLPQKGTIKLYKELS-CPL 466
+ KC +C R M + + Y G C + P ++ +++S CP+
Sbjct: 651 PEPIRKCPQCSRDMVLKTRKSGGFYLGCTGFPECRSAVWFPD-SVLEASRDVSVCPV 706
>F1MGY1_BOVIN (tr|F1MGY1) DNA topoisomerase OS=Bos taurus GN=TOP3A PE=3 SV=1
Length = 1002
Score = 275 bits (702), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 157/477 (32%), Positives = 239/477 (50%), Gaps = 19/477 (3%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIRVTHDHRDGVVEFSWKRHRLFN 292
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED V E+ K ++K RP L+TV L K+AS L M++AE
Sbjct: 293 HTACLVLYQMCMEDPRAMVVEVRSKAKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P D + Q +P WG + +L G PR G
Sbjct: 353 KLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGPTPRNGNKSDQ 412
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + D L D +LY+ I +HF+ S D + VE I E F G
Sbjct: 413 AHPPIHPTK--YTDSLQGDEQRLYELIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 470
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 471 MILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEADLIALMEKH 530
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 531 GIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 590
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSG-------- 416
+ LI +G+ D V+ +Q++KQ F V K +D F +
Sbjct: 591 DLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAATEVAPQDALPAV 650
Query: 417 -RILSKCGKCLRYMKYISAQPSRLYCGI-----CEEVYYLPQKGTIKLYKELS-CPL 466
+ KC +C R M + + Y G C + P ++ +++S CP+
Sbjct: 651 PEPIRKCPQCSRDMVLKTRKSGGFYLGCTGFPECRSAVWFPD-SVLEASRDVSVCPV 706
>A0JN73_BOVIN (tr|A0JN73) DNA topoisomerase OS=Bos taurus GN=TOP3A PE=2 SV=1
Length = 1002
Score = 275 bits (702), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 157/477 (32%), Positives = 239/477 (50%), Gaps = 19/477 (3%)
Query: 6 VLIAVYFSYGPCQTPTLGFCVQRYLQINTFKPEKFWSVNPYIVHSGYEIQLEWQRSKLFD 65
VL SYG CQ PTLGF V+R+ I F PE F + H ++ W+R +LF+
Sbjct: 233 VLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIRVTHDHRDGVVEFSWKRHRLFN 292
Query: 66 INVATMFQKLVAEDGLLEVTEISEKQETKSRPVGLNTVNLLKVASSALGFGPHMAMQLAE 125
+ ++ ED V E+ K ++K RP L+TV L K+AS L M++AE
Sbjct: 293 HTACLVLYQMCMEDPRAMVVEVRSKAKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352
Query: 126 RLYTQGFISYPRTESTAYPPSFDFRGALSAQANNPTWGNYVEGLLTNGYLKPRLGTDVGD 185
+LYTQG+ISYPRTE+ +P D + Q +P WG + +L G PR G
Sbjct: 353 KLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGPTPRNGNKSDQ 412
Query: 186 -HPPITPMRPAAEDMLGNDAWKLYQYICQHFIGTVSPDCKYARRKVEFSIGGESFHCTGQ 244
HPPI P + D L D +LY+ I +HF+ S D + VE I E F G
Sbjct: 413 AHPPIHPTK--YTDSLQGDEQRLYELIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGL 470
Query: 245 HVITKGFTAIMPWLAINDKNIPSFIKGQKIEVSKVELYEGTTTPPDYLTESELISLMEKN 304
++ + + + P+ +DK +P + +G + S VE+ +G T+PP LTE++LI+LMEK+
Sbjct: 471 MILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEADLIALMEKH 530
Query: 305 GIGTDASIPVHINNICERNYVQVQAGRKLVPTTLGITLVRGYQSIDPDLCLPDIRSFIEQ 364
GIGTDA+ HI I R YV + ++ +P LG+ LV GY S+ ++ PD+R+ +E
Sbjct: 531 GIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEA 590
Query: 365 QITLIAKGQIDHHRVVQHVIQQFKQKFCYFVKKIEAMDALFEAQFSTLVDSG-------- 416
+ LI +G+ D V+ +Q++KQ F V K +D F +
Sbjct: 591 DLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAATEVAPQDALPAV 650
Query: 417 -RILSKCGKCLRYMKYISAQPSRLYCGI-----CEEVYYLPQKGTIKLYKELS-CPL 466
+ KC +C R M + + Y G C + P ++ +++S CP+
Sbjct: 651 PEPIRKCPQCSRDMVLKTRKSGGFYLGCTGFPECRSAVWFPD-SVLEASRDVSVCPV 706