Miyakogusa Predicted Gene

Lj4g3v0877830.1
Show Alignment: 

BLASTP 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= Lj4g3v0877830.1 tr|I1L9S4|I1L9S4_SOYBN DNA topoisomerase 2
OS=Glycine max GN=Gma.48179 PE=3 SV=1,59.4,0,DNA_topoisoIV,DNA
topoisomerase, type IIA, subunit A/C-terminal; TOPISMRASEII,DNA
topoisomerase II, ,CUFF.48145.1
         (369 letters)

Database: trembl 
           41,451,118 sequences; 13,208,986,710 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

I1L9S4_SOYBN (tr|I1L9S4) DNA topoisomerase 2 OS=Glycine max PE=3...   461   e-127
I1MJQ7_SOYBN (tr|I1MJQ7) DNA topoisomerase 2 OS=Glycine max PE=3...   458   e-126
F6HBC4_VITVI (tr|F6HBC4) DNA topoisomerase 2 OS=Vitis vinifera G...   458   e-126
M1A903_SOLTU (tr|M1A903) DNA topoisomerase 2 OS=Solanum tuberosu...   453   e-125
M1A904_SOLTU (tr|M1A904) DNA topoisomerase 2 OS=Solanum tuberosu...   452   e-125
M1A902_SOLTU (tr|M1A902) DNA topoisomerase 2 OS=Solanum tuberosu...   452   e-124
K4AYE0_SOLLC (tr|K4AYE0) DNA topoisomerase 2 OS=Solanum lycopers...   449   e-124
Q8GSC4_TOBAC (tr|Q8GSC4) DNA topoisomerase 2 OS=Nicotiana tabacu...   448   e-123
M5X8I4_PRUPE (tr|M5X8I4) Uncharacterized protein OS=Prunus persi...   448   e-123
B9RVN3_RICCO (tr|B9RVN3) DNA topoisomerase II, putative OS=Ricin...   441   e-121
M0T361_MUSAM (tr|M0T361) DNA topoisomerase 2 OS=Musa acuminata s...   440   e-121
Q4JF74_SCUBA (tr|Q4JF74) DNA topoisomerase 2 OS=Scutellaria baic...   437   e-120
G7IWV9_MEDTR (tr|G7IWV9) DNA topoisomerase 2 OS=Medicago truncat...   436   e-120
I1ICW7_BRADI (tr|I1ICW7) DNA topoisomerase 2 OS=Brachypodium dis...   435   e-119
I1ICW6_BRADI (tr|I1ICW6) DNA topoisomerase 2 OS=Brachypodium dis...   434   e-119
Q6Z8D9_ORYSJ (tr|Q6Z8D9) DNA topoisomerase 2 OS=Oryza sativa sub...   431   e-118
I1P3D3_ORYGL (tr|I1P3D3) DNA topoisomerase 2 OS=Oryza glaberrima...   431   e-118
Q2L363_MALDO (tr|Q2L363) DNA topoisomerase 2 OS=Malus domestica ...   431   e-118
M4D3L7_BRARP (tr|M4D3L7) DNA topoisomerase 2 OS=Brassica rapa su...   430   e-118
K3YP99_SETIT (tr|K3YP99) DNA topoisomerase 2 OS=Setaria italica ...   430   e-118
J3LG54_ORYBR (tr|J3LG54) DNA topoisomerase 2 OS=Oryza brachyanth...   429   e-118
Q0DYE1_ORYSJ (tr|Q0DYE1) DNA topoisomerase 2 (Fragment) OS=Oryza...   429   e-117
D8SXJ0_SELML (tr|D8SXJ0) DNA topoisomerase 2 OS=Selaginella moel...   429   e-117
R0G2R4_9BRAS (tr|R0G2R4) Uncharacterized protein OS=Capsella rub...   428   e-117
D8RNR7_SELML (tr|D8RNR7) DNA topoisomerase 2 OS=Selaginella moel...   427   e-117
M0SVF6_MUSAM (tr|M0SVF6) DNA topoisomerase 2 OS=Musa acuminata s...   427   e-117
M8BEA6_AEGTA (tr|M8BEA6) Uncharacterized protein OS=Aegilops tau...   427   e-117
D8TGD2_SELML (tr|D8TGD2) DNA topoisomerase 2 (Fragment) OS=Selag...   427   e-117
M8AFG0_TRIUA (tr|M8AFG0) DNA topoisomerase 2 OS=Triticum urartu ...   427   e-117
N1QSK5_AEGTA (tr|N1QSK5) DNA topoisomerase 2 OS=Aegilops tauschi...   427   e-117
M7Z036_TRIUA (tr|M7Z036) DNA topoisomerase 2 OS=Triticum urartu ...   426   e-117
C5Y0E7_SORBI (tr|C5Y0E7) DNA topoisomerase 2 OS=Sorghum bicolor ...   426   e-117
B9HNR6_POPTR (tr|B9HNR6) DNA topoisomerase 2 OS=Populus trichoca...   426   e-117
C1E5N4_MICSR (tr|C1E5N4) DNA topoisomerase 2 OS=Micromonas sp. (...   423   e-116
E1Z4H4_CHLVA (tr|E1Z4H4) DNA topoisomerase 2 OS=Chlorella variab...   422   e-116
M0VXE2_HORVD (tr|M0VXE2) DNA topoisomerase 2 OS=Hordeum vulgare ...   422   e-115
B3H4G2_ARATH (tr|B3H4G2) DNA topoisomerase 2 OS=Arabidopsis thal...   421   e-115
D7L459_ARALL (tr|D7L459) DNA topoisomerase 2 OS=Arabidopsis lyra...   421   e-115
A9SRT5_PHYPA (tr|A9SRT5) DNA topoisomerase 2 (Fragment) OS=Physc...   421   e-115
B9GFC4_POPTR (tr|B9GFC4) DNA topoisomerase 2 OS=Populus trichoca...   421   e-115
M0VXE3_HORVD (tr|M0VXE3) Uncharacterized protein OS=Hordeum vulg...   421   e-115
C1MN24_MICPC (tr|C1MN24) DNA topoisomerase 2 OS=Micromonas pusil...   417   e-114
A9RWX5_PHYPA (tr|A9RWX5) DNA topoisomerase 2 (Fragment) OS=Physc...   416   e-114
D8U578_VOLCA (tr|D8U578) DNA topoisomerase 2 OS=Volvox carteri G...   416   e-114
A8JD08_CHLRE (tr|A8JD08) DNA topoisomerase 2 (Fragment) OS=Chlam...   414   e-113
A4S645_OSTLU (tr|A4S645) DNA topoisomerase 2 OS=Ostreococcus luc...   414   e-113
Q00XH2_OSTTA (tr|Q00XH2) DNA topoisomerase 2 OS=Ostreococcus tau...   413   e-113
M1V3P5_CYAME (tr|M1V3P5) DNA topoisomerase 2 OS=Cyanidioschyzon ...   412   e-112
K8F0A4_9CHLO (tr|K8F0A4) DNA topoisomerase 2 OS=Bathycoccus pras...   410   e-112
G7J2H1_MEDTR (tr|G7J2H1) DNA topoisomerase 2 OS=Medicago truncat...   409   e-112
Q0PWB2_PLEOS (tr|Q0PWB2) DNA topoisomerase 2 OS=Pleurotus ostrea...   404   e-110
F8QG51_SERL3 (tr|F8QG51) DNA topoisomerase 2 OS=Serpula lacryman...   403   e-110
F8PB32_SERL9 (tr|F8PB32) DNA topoisomerase 2 OS=Serpula lacryman...   402   e-110
J4ICG2_FIBRA (tr|J4ICG2) DNA topoisomerase 2 OS=Fibroporia radic...   402   e-109
E9C0T0_CAPO3 (tr|E9C0T0) DNA topoisomerase 2 OS=Capsaspora owcza...   401   e-109
L1IRG4_GUITH (tr|L1IRG4) DNA topoisomerase 2 OS=Guillardia theta...   400   e-109
L0P818_PNEJ8 (tr|L0P818) DNA topoisomerase 2 OS=Pneumocystis jir...   399   e-108
M2Y981_GALSU (tr|M2Y981) DNA topoisomerase 2 OS=Galdieria sulphu...   397   e-108
R7SSV1_DICSQ (tr|R7SSV1) Type II DNA topoisomerase OS=Dichomitus...   397   e-108
K3X2K0_PYTUL (tr|K3X2K0) DNA topoisomerase 2 OS=Pythium ultimum ...   396   e-108
K5XBZ3_PHACS (tr|K5XBZ3) DNA topoisomerase 2 OS=Phanerochaete ca...   395   e-108
M7NQN5_9ASCO (tr|M7NQN5) Uncharacterized protein OS=Pneumocystis...   395   e-107
E0S6I5_ENCIT (tr|E0S6I5) DNA topoisomerase 2 OS=Encephalitozoon ...   394   e-107
I6UKY3_ENCHA (tr|I6UKY3) DNA topoisomerase 2 OS=Encephalitozoon ...   394   e-107
I0YZH1_9CHLO (tr|I0YZH1) DNA topoisomerase 2 OS=Coccomyxa subell...   393   e-107
B6AEK2_CRYMR (tr|B6AEK2) DNA topoisomerase 2 OS=Cryptosporidium ...   392   e-106
M1KJ03_ENCCN (tr|M1KJ03) DNA topoisomerase 2 OS=Encephalitozoon ...   391   e-106
Q8SS63_ENCCU (tr|Q8SS63) DNA topoisomerase 2 OS=Encephalitozoon ...   391   e-106
I7ADX3_ENCRO (tr|I7ADX3) DNA topoisomerase 2 OS=Encephalitozoon ...   389   e-106
J9HZI4_9SPIT (tr|J9HZI4) DNA topoisomerase 2 OS=Oxytricha trifal...   389   e-106
M1HX85_9PHYC (tr|M1HX85) DNA topoisomerase II OS=Paramecium burs...   388   e-105
R9AGH6_WALIC (tr|R9AGH6) DNA topoisomerase 2 OS=Wallemia ichthyo...   388   e-105
F0WKX4_9STRA (tr|F0WKX4) DNA topoisomerase 2 OS=Albugo laibachii...   386   e-105
M2RR97_CERSU (tr|M2RR97) DNA topoisomerase 2 OS=Ceriporiopsis su...   386   e-105
M1I6I8_9PHYC (tr|M1I6I8) DNA topoisomerase II OS=Paramecium burs...   384   e-104
D2UZM0_NAEGR (tr|D2UZM0) DNA topoisomerase 2 OS=Naegleria gruber...   384   e-104
A8N230_COPC7 (tr|A8N230) DNA topoisomerase 2 OS=Coprinopsis cine...   384   e-104
A1IGC8_COPCI (tr|A1IGC8) DNA topoisomerase 2 OS=Coprinopsis cine...   384   e-104
Q5KSK9_COPCI (tr|Q5KSK9) DNA topoisomerase 2 OS=Coprinopsis cine...   383   e-104
M1HSV9_9PHYC (tr|M1HSV9) DNA topoisomerase II OS=Paramecium burs...   383   e-104
F4R8C9_MELLP (tr|F4R8C9) DNA topoisomerase 2 OS=Melampsora laric...   382   e-104
B7XIW3_ENTBH (tr|B7XIW3) DNA topoisomerase 2 OS=Enterocytozoon b...   382   e-103
M1I137_9PHYC (tr|M1I137) DNA topoisomerase II OS=Paramecium burs...   381   e-103
M1HLM1_9PHYC (tr|M1HLM1) DNA topoisomerase II OS=Paramecium burs...   381   e-103
M1HIH7_9PHYC (tr|M1HIH7) DNA topoisomerase II OS=Paramecium burs...   381   e-103
Q5XLS4_9PHYC (tr|Q5XLS4) Topoisomerase II OS=Paramecium bursaria...   381   e-103
M1HJ96_9PHYC (tr|M1HJ96) DNA topoisomerase II OS=Paramecium burs...   381   e-103
D8QKJ8_SCHCM (tr|D8QKJ8) DNA topoisomerase 2 OS=Schizophyllum co...   380   e-103
M1I0N6_9PHYC (tr|M1I0N6) DNA topoisomerase II OS=Acanthocystis t...   380   e-103
R4X883_9ASCO (tr|R4X883) DNA topoisomerase 2 OS=Taphrina deforma...   380   e-103
J9IBE1_9SPIT (tr|J9IBE1) DNA topoisomerase 2 OS=Oxytricha trifal...   379   e-103
A7IUS6_PBCVM (tr|A7IUS6) Putative uncharacterized protein M546R ...   379   e-102
H3G7M6_PHYRM (tr|H3G7M6) DNA topoisomerase 2 (Fragment) OS=Phyto...   379   e-102
M1IG07_9PHYC (tr|M1IG07) DNA topoisomerase II OS=Paramecium burs...   379   e-102
M1HEE6_9PHYC (tr|M1HEE6) DNA topoisomerase II OS=Paramecium burs...   379   e-102
F4PXP4_DICFS (tr|F4PXP4) DNA topoisomerase 2 OS=Dictyostelium fa...   379   e-102
G3B4R2_CANTC (tr|G3B4R2) DNA topoisomerase 2 OS=Candida tenuis (...   379   e-102
M1HR94_9PHYC (tr|M1HR94) DNA topoisomerase II OS=Paramecium burs...   379   e-102
F1KQV5_ASCSU (tr|F1KQV5) DNA topoisomerase 2 OS=Ascaris suum PE=...   378   e-102
F2U845_SALS5 (tr|F2U845) DNA topoisomerase 2 OS=Salpingoeca sp. ...   378   e-102
G0T007_RHOG2 (tr|G0T007) DNA topoisomerase 2 OS=Rhodotorula glut...   378   e-102
F2U844_SALS5 (tr|F2U844) DNA topoisomerase 2 OS=Salpingoeca sp. ...   378   e-102
F1KQU1_ASCSU (tr|F1KQU1) DNA topoisomerase 2 OS=Ascaris suum PE=...   378   e-102
K6UXA3_9APIC (tr|K6UXA3) DNA topoisomerase 2 OS=Plasmodium cynom...   378   e-102
M7WCM6_RHOTO (tr|M7WCM6) DNA topoisomerase II OS=Rhodosporidium ...   377   e-102
D0NA12_PHYIT (tr|D0NA12) DNA topoisomerase 2 OS=Phytophthora inf...   377   e-102
M5E815_MALSM (tr|M5E815) Genomic scaffold, msy_sf_6 OS=Malassezi...   377   e-102
M1HT83_9PHYC (tr|M1HT83) DNA topoisomerase II OS=Paramecium burs...   377   e-102
M1I7C8_9PHYC (tr|M1I7C8) DNA topoisomerase II OS=Acanthocystis t...   377   e-102
D7G0Y6_ECTSI (tr|D7G0Y6) DNA topoisomerase 2 OS=Ectocarpus silic...   377   e-102
Q7RJ69_PLAYO (tr|Q7RJ69) DNA topoisomerase 2 OS=Plasmodium yoeli...   377   e-102
M1I5G7_9PHYC (tr|M1I5G7) DNA topoisomerase II OS=Acanthocystis t...   377   e-102
G0QS48_ICHMG (tr|G0QS48) DNA topoisomerase 2 OS=Ichthyophthirius...   377   e-102
M1HFA5_9PHYC (tr|M1HFA5) DNA topoisomerase II OS=Paramecium burs...   377   e-102
H8ZD93_NEMS1 (tr|H8ZD93) DNA topoisomerase 2 OS=Nematocida sp. 1...   376   e-102
Q7Z2D0_PLAFA (tr|Q7Z2D0) DNA topoisomerase 2 OS=Plasmodium falci...   376   e-102
G7DZ82_MIXOS (tr|G7DZ82) DNA topoisomerase 2 OS=Mixia osmundae (...   376   e-102
M1HJQ6_9PHYC (tr|M1HJQ6) DNA topoisomerase II OS=Paramecium burs...   376   e-102
Q8ILC8_PLAF7 (tr|Q8ILC8) DNA topoisomerase 2 OS=Plasmodium falci...   376   e-102
Q7YZS4_PHYPO (tr|Q7YZS4) DNA topoisomerase 2 OS=Physarum polycep...   376   e-102
Q4Y8Y8_PLACH (tr|Q4Y8Y8) DNA topoisomerase II, putative (Fragmen...   376   e-102
J3PRY3_PUCT1 (tr|J3PRY3) DNA topoisomerase 2 OS=Puccinia tritici...   376   e-102
M1H9T1_9PHYC (tr|M1H9T1) DNA topoisomerase II OS=Acanthocystis t...   375   e-101
F4NTP0_BATDJ (tr|F4NTP0) DNA topoisomerase 2 (Fragment) OS=Batra...   375   e-101
G5AAW7_PHYSP (tr|G5AAW7) DNA topoisomerase 2 (Fragment) OS=Phyto...   375   e-101
M1HUY5_9PHYC (tr|M1HUY5) DNA topoisomerase II OS=Acanthocystis t...   375   e-101
I3ESC1_NEMP1 (tr|I3ESC1) DNA topoisomerase 2 OS=Nematocida paris...   375   e-101
I3EH32_NEMP3 (tr|I3EH32) DNA topoisomerase 2 OS=Nematocida paris...   375   e-101
Q5CQG8_CRYPI (tr|Q5CQG8) DNA topoisomerase 2 OS=Cryptosporidium ...   375   e-101
O41065_PBCV1 (tr|O41065) DNA topoisomerase II OS=Paramecium burs...   375   e-101
E6R0Q0_CRYGW (tr|E6R0Q0) DNA topoisomerase 2 OS=Cryptococcus gat...   375   e-101
B3LBF9_PLAKH (tr|B3LBF9) DNA topoisomerase 2 OS=Plasmodium knowl...   374   e-101
A5K0R4_PLAVS (tr|A5K0R4) DNA topoisomerase 2 OS=Plasmodium vivax...   374   e-101
I4YK24_WALSC (tr|I4YK24) DNA topoisomerase 2 OS=Wallemia sebi (s...   374   e-101
M9LUR2_9BASI (tr|M9LUR2) Uncharacterized protein OS=Pseudozyma a...   374   e-101
Q5KP97_CRYNJ (tr|Q5KP97) DNA topoisomerase 2 OS=Cryptococcus neo...   374   e-101
F5HDJ4_CRYNB (tr|F5HDJ4) DNA topoisomerase 2 OS=Cryptococcus neo...   374   e-101
M1HXD2_9PHYC (tr|M1HXD2) DNA topoisomerase II OS=Paramecium burs...   374   e-101
M1ILU4_9PHYC (tr|M1ILU4) DNA topoisomerase II OS=Acanthocystis t...   373   e-101
A7J7Q3_PBCVF (tr|A7J7Q3) Putative uncharacterized protein N549R ...   373   e-101
A8Q990_BRUMA (tr|A8Q990) DNA topoisomerase 2 OS=Brugia malayi GN...   373   e-101
E3JRR8_PUCGT (tr|E3JRR8) DNA topoisomerase 2 OS=Puccinia gramini...   373   e-101
M1IMS0_9PHYC (tr|M1IMS0) DNA topoisomerase II OS=Acanthocystis t...   373   e-101
H6BPZ5_EXODN (tr|H6BPZ5) DNA topoisomerase 2 OS=Exophiala dermat...   372   e-100
M1IDW0_9PHYC (tr|M1IDW0) DNA topoisomerase II OS=Acanthocystis t...   372   e-100
F1Q8Y8_DANRE (tr|F1Q8Y8) DNA topoisomerase 2 OS=Danio rerio GN=t...   372   e-100
Q1LUT2_DANRE (tr|Q1LUT2) Uncharacterized protein OS=Danio rerio ...   372   e-100
L7MAX8_9ACAR (tr|L7MAX8) DNA topoisomerase 2 (Fragment) OS=Rhipi...   371   e-100
M1I7P4_9PHYC (tr|M1I7P4) DNA topoisomerase II OS=Paramecium burs...   371   e-100
J4C854_THEOR (tr|J4C854) DNA topoisomerase 2 OS=Theileria orient...   371   e-100
A7RCG0_PBCVA (tr|A7RCG0) Putative uncharacterized protein C707L ...   370   e-100
J9D3E4_EDHAE (tr|J9D3E4) DNA topoisomerase 2 OS=Edhazardia aedis...   370   e-100
E9B049_LEIMU (tr|E9B049) DNA topoisomerase 2 OS=Leishmania mexic...   370   e-100
H2LXG9_ORYLA (tr|H2LXG9) DNA topoisomerase 2 (Fragment) OS=Oryzi...   370   e-100
A8NS91_BRUMA (tr|A8NS91) DNA topoisomerase 2 OS=Brugia malayi GN...   370   e-100
Q7PWM2_ANOGA (tr|Q7PWM2) DNA topoisomerase 2 (Fragment) OS=Anoph...   370   e-100
J9EX29_WUCBA (tr|J9EX29) DNA topoisomerase 2 (Fragment) OS=Wuche...   370   e-100
R9NYN7_9BASI (tr|R9NYN7) DNA topoisomerase II OS=Pseudozyma hube...   370   e-100
A7IXV6_PBCVN (tr|A7IXV6) Putative uncharacterized protein B781L ...   370   e-100
B7P0P1_IXOSC (tr|B7P0P1) DNA topoisomerase 2 OS=Ixodes scapulari...   370   e-100
A7K9G1_9PHYC (tr|A7K9G1) Putative uncharacterized protein Z551L ...   369   e-100
E0VS84_PEDHC (tr|E0VS84) DNA topoisomerase 2 OS=Pediculus humanu...   369   e-100
K9IC41_AGABB (tr|K9IC41) DNA topoisomerase 2 OS=Agaricus bisporu...   369   e-100
G3P0Y7_GASAC (tr|G3P0Y7) DNA topoisomerase 2 (Fragment) OS=Gaste...   369   e-99 
C5DMF0_LACTC (tr|C5DMF0) DNA topoisomerase 2 OS=Lachancea thermo...   369   e-99 
L7JVE8_TRAHO (tr|L7JVE8) DNA topoisomerase 2 (Fragment) OS=Trach...   369   1e-99
I2FWY2_USTH4 (tr|I2FWY2) DNA topoisomerase 2 OS=Ustilago hordei ...   369   1e-99
A3AAF2_ORYSJ (tr|A3AAF2) DNA topoisomerase 2 OS=Oryza sativa sub...   369   1e-99
A2X8M2_ORYSI (tr|A2X8M2) DNA topoisomerase 2 OS=Oryza sativa sub...   369   1e-99
D3B7U7_POLPA (tr|D3B7U7) DNA topoisomerase 2 OS=Polysphondylium ...   369   1e-99
E9BJW5_LEIDB (tr|E9BJW5) DNA topoisomerase 2 OS=Leishmania donov...   368   2e-99
Q4Z0B9_PLABA (tr|Q4Z0B9) DNA topoisomerase 2 (Fragment) OS=Plasm...   368   2e-99
M1GWJ2_9PHYC (tr|M1GWJ2) DNA topoisomerase II OS=Acanthocystis t...   368   2e-99
Q4P8R2_USTMA (tr|Q4P8R2) DNA topoisomerase 2 OS=Ustilago maydis ...   368   2e-99
K5Y6A9_AGABU (tr|K5Y6A9) DNA topoisomerase 2 OS=Agaricus bisporu...   368   2e-99
K0KT01_WICCF (tr|K0KT01) DNA topoisomerase 2 OS=Wickerhamomyces ...   368   2e-99
I1C6D9_RHIO9 (tr|I1C6D9) DNA topoisomerase 2 OS=Rhizopus delemar...   368   2e-99
J0DYM4_LOALO (tr|J0DYM4) DNA topoisomerase 2 OS=Loa loa GN=LOAG_...   368   2e-99
M1HTB7_9PHYC (tr|M1HTB7) DNA topoisomerase II OS=Paramecium burs...   368   2e-99
A4I3V9_LEIIN (tr|A4I3V9) DNA topoisomerase 2 (Fragment) OS=Leish...   368   2e-99
L8GML2_ACACA (tr|L8GML2) DNA topoisomerase 2 OS=Acanthamoeba cas...   368   3e-99
G0R0E4_ICHMG (tr|G0R0E4) Putative uncharacterized protein OS=Ich...   368   3e-99
Q4Q836_LEIMA (tr|Q4Q836) DNA topoisomerase 2 OS=Leishmania major...   367   3e-99
M1IA64_9PHYC (tr|M1IA64) DNA topoisomerase II OS=Paramecium burs...   367   4e-99
A5E7X7_LODEL (tr|A5E7X7) DNA topoisomerase 2 OS=Lodderomyces elo...   367   6e-99
A4HGT2_LEIBR (tr|A4HGT2) DNA topoisomerase 2 OS=Leishmania brazi...   366   6e-99
J0XI42_LOALO (tr|J0XI42) DNA topoisomerase 2 OS=Loa loa GN=LOAG_...   366   7e-99
M1HYL7_9PHYC (tr|M1HYL7) DNA topoisomerase II OS=Acanthocystis t...   366   7e-99
H2LHR6_ORYLA (tr|H2LHR6) DNA topoisomerase 2 (Fragment) OS=Oryzi...   365   1e-98
M1I1I6_9PHYC (tr|M1I1I6) DNA topoisomerase II OS=Paramecium burs...   365   1e-98
A7ANB1_BABBO (tr|A7ANB1) DNA topoisomerase 2 OS=Babesia bovis GN...   365   1e-98
Q6BQW4_DEBHA (tr|Q6BQW4) DNA topoisomerase 2 OS=Debaryomyces han...   365   1e-98
M5FVQ8_DACSP (tr|M5FVQ8) DNA topoisomerase II OS=Dacryopinax sp....   365   2e-98
G3UST0_MELGA (tr|G3UST0) DNA topoisomerase 2 (Fragment) OS=Melea...   364   3e-98
R0JC34_ANAPL (tr|R0JC34) DNA topoisomerase 2-beta (Fragment) OS=...   364   3e-98
H0YZ82_TAEGU (tr|H0YZ82) DNA topoisomerase 2 OS=Taeniopygia gutt...   364   3e-98
E6ZGS7_DICLA (tr|E6ZGS7) DNA topoisomerase 2 (Fragment) OS=Dicen...   364   3e-98
G3UST4_MELGA (tr|G3UST4) DNA topoisomerase 2 (Fragment) OS=Melea...   364   3e-98
G3NZ45_GASAC (tr|G3NZ45) DNA topoisomerase 2 OS=Gasterosteus acu...   364   4e-98
A0D9B8_PARTE (tr|A0D9B8) DNA topoisomerase 2 OS=Paramecium tetra...   364   4e-98
G1NF24_MELGA (tr|G1NF24) DNA topoisomerase 2 (Fragment) OS=Melea...   364   4e-98
E7R9F3_PICAD (tr|E7R9F3) DNA topoisomerase 2 OS=Pichia angusta (...   363   4e-98
E3X4B6_ANODA (tr|E3X4B6) DNA topoisomerase 2 OS=Anopheles darlin...   363   4e-98
G1NAT9_MELGA (tr|G1NAT9) DNA topoisomerase 2 (Fragment) OS=Melea...   363   4e-98
H2UY95_TAKRU (tr|H2UY95) DNA topoisomerase 2 (Fragment) OS=Takif...   363   5e-98
Q0IEA2_AEDAE (tr|Q0IEA2) DNA topoisomerase 2 (Fragment) OS=Aedes...   363   5e-98
H2UY96_TAKRU (tr|H2UY96) DNA topoisomerase 2 (Fragment) OS=Takif...   363   5e-98
E1BZ19_CHICK (tr|E1BZ19) DNA topoisomerase 2 OS=Gallus gallus GN...   363   6e-98
I7M5X3_TETTS (tr|I7M5X3) DNA topoisomerase 2 OS=Tetrahymena ther...   363   7e-98
H2UY97_TAKRU (tr|H2UY97) DNA topoisomerase 2 (Fragment) OS=Takif...   363   7e-98
E5D8G5_9AGAR (tr|E5D8G5) DNA topoisomerase 2 OS=Omphalotus nidif...   363   7e-98
Q2PQ58_9TRYP (tr|Q2PQ58) DNA topoisomerase 2 OS=Trypanosoma bruc...   363   8e-98
D0A927_TRYB9 (tr|D0A927) DNA topoisomerase 2 OS=Trypanosoma bruc...   363   8e-98
H3D5N4_TETNG (tr|H3D5N4) DNA topoisomerase 2 (Fragment) OS=Tetra...   363   8e-98
H3C592_TETNG (tr|H3C592) DNA topoisomerase 2 (Fragment) OS=Tetra...   362   9e-98
F7BGW3_XENTR (tr|F7BGW3) DNA topoisomerase 2 OS=Xenopus tropical...   362   1e-97
B0WRP3_CULQU (tr|B0WRP3) DNA topoisomerase 2 OS=Culex quinquefas...   362   1e-97
F2QWR7_PICP7 (tr|F2QWR7) DNA topoisomerase 2 OS=Komagataella pas...   362   1e-97
A0C7Z3_PARTE (tr|A0C7Z3) DNA topoisomerase 2 OS=Paramecium tetra...   362   1e-97
I3JVT3_ORENI (tr|I3JVT3) DNA topoisomerase 2 OS=Oreochromis nilo...   362   1e-97
B9WF18_CANDC (tr|B9WF18) DNA topoisomerase 2 OS=Candida dublinie...   362   1e-97
K7FJR3_PELSI (tr|K7FJR3) DNA topoisomerase 2 OS=Pelodiscus sinen...   362   1e-97
C5FWK9_ARTOC (tr|C5FWK9) DNA topoisomerase 2 OS=Arthroderma otae...   362   2e-97
M4ARH2_XIPMA (tr|M4ARH2) DNA topoisomerase 2 OS=Xiphophorus macu...   362   2e-97
I7IP59_BABMI (tr|I7IP59) DNA topoisomerase 2 OS=Babesia microti ...   362   2e-97
B6QAM9_PENMQ (tr|B6QAM9) DNA topoisomerase 2 OS=Penicillium marn...   362   2e-97
Q6CTC1_KLULA (tr|Q6CTC1) DNA topoisomerase 2 OS=Kluyveromyces la...   362   2e-97
H3A5L5_LATCH (tr|H3A5L5) DNA topoisomerase 2 OS=Latimeria chalum...   361   2e-97
H0YVT8_TAEGU (tr|H0YVT8) DNA topoisomerase 2 OS=Taeniopygia gutt...   361   2e-97
F1KQW9_ASCSU (tr|F1KQW9) DNA topoisomerase 2 OS=Ascaris suum PE=...   361   2e-97
F0ZNB2_DICPU (tr|F0ZNB2) DNA topoisomerase 2 (Fragment) OS=Dicty...   361   2e-97
Q5A1E7_CANAL (tr|Q5A1E7) DNA topoisomerase 2 OS=Candida albicans...   361   2e-97
R0L0H5_ANAPL (tr|R0L0H5) DNA topoisomerase 2-alpha (Fragment) OS...   361   2e-97
F1KQW6_ASCSU (tr|F1KQW6) DNA topoisomerase 2 OS=Ascaris suum PE=...   361   3e-97
K9IV03_DESRO (tr|K9IV03) DNA topoisomerase 2 (Fragment) OS=Desmo...   361   3e-97
H3A5L4_LATCH (tr|H3A5L4) DNA topoisomerase 2 (Fragment) OS=Latim...   361   3e-97
G1XKF5_ARTOA (tr|G1XKF5) DNA topoisomerase 2 OS=Arthrobotrys oli...   360   3e-97
H3DLE0_TETNG (tr|H3DLE0) DNA topoisomerase 2 (Fragment) OS=Tetra...   360   3e-97
E1FWC3_LOALO (tr|E1FWC3) Uncharacterized protein OS=Loa loa GN=L...   360   3e-97
B7G2L6_PHATC (tr|B7G2L6) DNA topoisomerase 2 (Fragment) OS=Phaeo...   360   4e-97
Q8X1U1_PENMA (tr|Q8X1U1) DNA topoisomerase 2 (Fragment) OS=Penic...   360   4e-97
K9IVY4_DESRO (tr|K9IVY4) DNA topoisomerase 2 (Fragment) OS=Desmo...   360   4e-97
Q4S4N6_TETNG (tr|Q4S4N6) DNA topoisomerase 2 (Fragment) OS=Tetra...   360   4e-97
K9IVG7_DESRO (tr|K9IVG7) DNA topoisomerase 2 (Fragment) OS=Desmo...   360   4e-97
K3WUW3_PYTUL (tr|K3WUW3) DNA topoisomerase 2 OS=Pythium ultimum ...   360   4e-97
Q8J2R8_ARTOT (tr|Q8J2R8) DNA topoisomerase 2 (Fragment) OS=Arthr...   360   4e-97
C5MDS2_CANTT (tr|C5MDS2) DNA topoisomerase 2 OS=Candida tropical...   360   5e-97
A1CUL0_ASPCL (tr|A1CUL0) DNA topoisomerase 2 OS=Aspergillus clav...   360   6e-97
M3X192_FELCA (tr|M3X192) DNA topoisomerase 2 OS=Felis catus GN=T...   360   6e-97
G3WB20_SARHA (tr|G3WB20) DNA topoisomerase 2 (Fragment) OS=Sarco...   360   6e-97
D2HUZ8_AILME (tr|D2HUZ8) DNA topoisomerase 2 (Fragment) OS=Ailur...   360   6e-97
H2UY94_TAKRU (tr|H2UY94) DNA topoisomerase 2 OS=Takifugu rubripe...   360   6e-97
G9KUN4_MUSPF (tr|G9KUN4) DNA topoisomerase 2 (Fragment) OS=Muste...   360   6e-97
G1PAB1_MYOLU (tr|G1PAB1) DNA topoisomerase 2 OS=Myotis lucifugus...   359   7e-97
I2CT72_MACMU (tr|I2CT72) DNA topoisomerase 2 OS=Macaca mulatta G...   359   9e-97
M3YL11_MUSPF (tr|M3YL11) DNA topoisomerase 2 OS=Mustela putorius...   359   9e-97
Q383C4_TRYB2 (tr|Q383C4) DNA topoisomerase 2 OS=Trypanosoma bruc...   359   9e-97
G0NR59_CAEBE (tr|G0NR59) DNA topoisomerase 2 OS=Caenorhabditis b...   359   9e-97
I7MA91_TETTS (tr|I7MA91) DNA topoisomerase 2 OS=Tetrahymena ther...   359   9e-97
E4US63_ARTGP (tr|E4US63) DNA topoisomerase 2 OS=Arthroderma gyps...   359   1e-96
M1HNM0_9PHYC (tr|M1HNM0) DNA topoisomerase II OS=Paramecium burs...   359   1e-96
L8ISS2_BOSMU (tr|L8ISS2) DNA topoisomerase 2 (Fragment) OS=Bos g...   359   1e-96
G3WFK3_SARHA (tr|G3WFK3) DNA topoisomerase 2 OS=Sarcophilus harr...   359   1e-96
F7E5A9_MACMU (tr|F7E5A9) DNA topoisomerase 2 OS=Macaca mulatta G...   359   1e-96
Q6PUA3_TETTH (tr|Q6PUA3) DNA topoisomerase 2 OS=Tetrahymena ther...   359   1e-96
F1MU48_BOVIN (tr|F1MU48) DNA topoisomerase 2 (Fragment) OS=Bos t...   359   1e-96
L9JX05_TUPCH (tr|L9JX05) DNA topoisomerase 2 OS=Tupaia chinensis...   359   1e-96
G3AEF9_SPAPN (tr|G3AEF9) DNA topoisomerase 2 OS=Spathaspora pass...   359   1e-96
Q2PQ59_9TRYP (tr|Q2PQ59) DNA topoisomerase 2 OS=Trypanosoma bruc...   358   1e-96
D0A926_TRYB9 (tr|D0A926) DNA topoisomerase 2 OS=Trypanosoma bruc...   358   1e-96
G7NY94_MACFA (tr|G7NY94) DNA topoisomerase 2 (Fragment) OS=Macac...   358   1e-96
H9F8L1_MACMU (tr|H9F8L1) DNA topoisomerase 2 (Fragment) OS=Macac...   358   1e-96
J9K4Y7_ACYPI (tr|J9K4Y7) DNA topoisomerase 2 OS=Acyrthosiphon pi...   358   1e-96
K7F361_PELSI (tr|K7F361) DNA topoisomerase 2 OS=Pelodiscus sinen...   358   1e-96
H2B0P0_KAZAF (tr|H2B0P0) DNA topoisomerase 2 OS=Kazachstania afr...   358   1e-96
G1QUD9_NOMLE (tr|G1QUD9) DNA topoisomerase 2 OS=Nomascus leucoge...   358   1e-96
H2QM73_PANTR (tr|H2QM73) DNA topoisomerase 2 OS=Pan troglodytes ...   358   2e-96
F6S771_CALJA (tr|F6S771) DNA topoisomerase 2 OS=Callithrix jacch...   358   2e-96
Q71UH4_HUMAN (tr|Q71UH4) DNA topoisomerase 2 (Fragment) OS=Homo ...   358   2e-96
K7CLW1_PANTR (tr|K7CLW1) DNA topoisomerase 2 OS=Pan troglodytes ...   358   2e-96
G3SGP2_GORGO (tr|G3SGP2) DNA topoisomerase 2 OS=Gorilla gorilla ...   358   2e-96
H2PBB5_PONAB (tr|H2PBB5) DNA topoisomerase 2 OS=Pongo abelii GN=...   358   2e-96
A3GF24_PICST (tr|A3GF24) DNA topoisomerase 2 OS=Scheffersomyces ...   358   2e-96
M7AX24_CHEMY (tr|M7AX24) DNA topoisomerase 2-beta (Fragment) OS=...   358   2e-96
E9PCY5_HUMAN (tr|E9PCY5) DNA topoisomerase 2 (Fragment) OS=Homo ...   358   2e-96
F7CL38_HORSE (tr|F7CL38) DNA topoisomerase 2 (Fragment) OS=Equus...   358   2e-96
G1KAM2_ANOCA (tr|G1KAM2) DNA topoisomerase 2 OS=Anolis carolinen...   358   2e-96
H2SY53_TAKRU (tr|H2SY53) DNA topoisomerase 2 OS=Takifugu rubripe...   358   2e-96
A8PTE9_MALGO (tr|A8PTE9) DNA topoisomerase 2 OS=Malassezia globo...   358   2e-96
F7D0D3_MONDO (tr|F7D0D3) DNA topoisomerase 2 OS=Monodelphis dome...   358   2e-96
E9HGV5_DAPPU (tr|E9HGV5) DNA topoisomerase 2 OS=Daphnia pulex GN...   358   2e-96
H2SY52_TAKRU (tr|H2SY52) DNA topoisomerase 2 (Fragment) OS=Takif...   358   2e-96
Q14TE9_RAT (tr|Q14TE9) DNA topoisomerase 2 OS=Rattus norvegicus ...   358   2e-96
H0VTB2_CAVPO (tr|H0VTB2) DNA topoisomerase 2 (Fragment) OS=Cavia...   358   2e-96
B4DKD0_HUMAN (tr|B4DKD0) DNA topoisomerase 2 (Fragment) OS=Homo ...   358   2e-96
H2SY55_TAKRU (tr|H2SY55) DNA topoisomerase 2 (Fragment) OS=Takif...   358   2e-96
Q8J2R7_ARTGY (tr|Q8J2R7) DNA topoisomerase 2 (Fragment) OS=Arthr...   358   2e-96
G8YSX5_PICSO (tr|G8YSX5) DNA topoisomerase 2 OS=Pichia sorbitoph...   358   2e-96
B8M038_TALSN (tr|B8M038) DNA topoisomerase 2 OS=Talaromyces stip...   357   3e-96
Q6INT0_XENLA (tr|Q6INT0) DNA topoisomerase 2 OS=Xenopus laevis G...   357   3e-96
G8YUD2_PICSO (tr|G8YUD2) DNA topoisomerase 2 OS=Pichia sorbitoph...   357   3e-96
G3I5N5_CRIGR (tr|G3I5N5) DNA topoisomerase 2 OS=Cricetulus grise...   357   3e-96
Q4UEG9_THEAN (tr|Q4UEG9) DNA topoisomerase 2 OS=Theileria annula...   357   3e-96
Q8J2R6_EPIFL (tr|Q8J2R6) DNA topoisomerase 2 (Fragment) OS=Epide...   357   3e-96
O55079_CRILO (tr|O55079) DNA topoisomerase 2 OS=Cricetulus longi...   357   3e-96
F1M7A0_RAT (tr|F1M7A0) DNA topoisomerase 2 (Fragment) OS=Rattus ...   357   3e-96
F1NZF0_CHICK (tr|F1NZF0) DNA topoisomerase 2 OS=Gallus gallus GN...   357   3e-96
Q76C42_9EURO (tr|Q76C42) DNA topoisomerase 2 (Fragment) OS=Arthr...   357   3e-96
H2SY54_TAKRU (tr|H2SY54) DNA topoisomerase 2 (Fragment) OS=Takif...   357   3e-96
Q76C40_9EURO (tr|Q76C40) DNA topoisomerase 2 (Fragment) OS=Arthr...   357   3e-96
L5L3V1_PTEAL (tr|L5L3V1) DNA topoisomerase 2 OS=Pteropus alecto ...   357   4e-96
Q76C41_ARTGY (tr|Q76C41) DNA topoisomerase 2 (Fragment) OS=Arthr...   357   4e-96
A1DP90_NEOFI (tr|A1DP90) DNA topoisomerase 2 OS=Neosartorya fisc...   357   4e-96
Q4N523_THEPA (tr|Q4N523) DNA topoisomerase 2 OS=Theileria parva ...   357   4e-96
I3KVE9_ORENI (tr|I3KVE9) DNA topoisomerase 2 OS=Oreochromis nilo...   357   4e-96
F1Q2M4_CANFA (tr|F1Q2M4) DNA topoisomerase 2 OS=Canis familiaris...   357   4e-96
Q8X1U7_9EURO (tr|Q8X1U7) DNA topoisomerase 2 (Fragment) OS=Asper...   357   4e-96
Q0CSB2_ASPTN (tr|Q0CSB2) DNA topoisomerase 2 OS=Aspergillus terr...   357   4e-96
I3KVE8_ORENI (tr|I3KVE8) DNA topoisomerase 2 OS=Oreochromis nilo...   357   4e-96
G5BF97_HETGA (tr|G5BF97) DNA topoisomerase 2 OS=Heterocephalus g...   357   5e-96
F7ABY1_MONDO (tr|F7ABY1) DNA topoisomerase 2 OS=Monodelphis dome...   357   5e-96
Q76C39_9EURO (tr|Q76C39) DNA topoisomerase 2 (Fragment) OS=Arthr...   357   5e-96
H0WKM4_OTOGA (tr|H0WKM4) DNA topoisomerase 2 (Fragment) OS=Otole...   357   5e-96
C0SGV5_PARBP (tr|C0SGV5) DNA topoisomerase 2 OS=Paracoccidioides...   357   6e-96
G8BHF5_CANPC (tr|G8BHF5) DNA topoisomerase 2 OS=Candida parapsil...   357   6e-96
F7A8M1_ORNAN (tr|F7A8M1) DNA topoisomerase 2 OS=Ornithorhynchus ...   357   6e-96
J9PAY8_CANFA (tr|J9PAY8) DNA topoisomerase 2 OS=Canis familiaris...   356   6e-96
G1NW71_MYOLU (tr|G1NW71) DNA topoisomerase 2 (Fragment) OS=Myoti...   356   6e-96
L8IH03_BOSMU (tr|L8IH03) DNA topoisomerase 2 (Fragment) OS=Bos g...   356   6e-96
C1GXB2_PARBA (tr|C1GXB2) DNA topoisomerase 2 OS=Paracoccidioides...   356   6e-96
C1GGA2_PARBD (tr|C1GGA2) DNA topoisomerase 2 OS=Paracoccidioides...   356   7e-96
L5MEK8_MYODS (tr|L5MEK8) DNA topoisomerase 2 (Fragment) OS=Myoti...   356   8e-96
F1MDU7_BOVIN (tr|F1MDU7) DNA topoisomerase 2 OS=Bos taurus GN=TO...   356   8e-96
G5AX78_HETGA (tr|G5AX78) DNA topoisomerase 2 (Fragment) OS=Heter...   356   9e-96
Q76C44_9EURO (tr|Q76C44) DNA topoisomerase 2 (Fragment) OS=Arthr...   356   9e-96
Q6PUA4_TETTH (tr|Q6PUA4) DNA topoisomerase 2 OS=Tetrahymena ther...   356   1e-95
Q8J2S1_TRIRU (tr|Q8J2S1) DNA topoisomerase 2 (Fragment) OS=Trich...   356   1e-95
G3YF10_ASPNA (tr|G3YF10) DNA topoisomerase 2 OS=Aspergillus nige...   355   1e-95
Q7ZXS2_XENLA (tr|Q7ZXS2) DNA topoisomerase 2 (Fragment) OS=Xenop...   355   1e-95
Q8X1U2_PENCI (tr|Q8X1U2) DNA topoisomerase 2 (Fragment) OS=Penic...   355   1e-95
C6H7L1_AJECH (tr|C6H7L1) DNA topoisomerase 2 OS=Ajellomyces caps...   355   1e-95
G0V251_TRYCI (tr|G0V251) DNA topoisomerase 2 OS=Trypanosoma cong...   355   1e-95
F0UWA9_AJEC8 (tr|F0UWA9) DNA topoisomerase 2 OS=Ajellomyces caps...   355   1e-95
A5AB02_ASPNC (tr|A5AB02) DNA topoisomerase 2 OS=Aspergillus nige...   355   1e-95
R7QHX8_CHOCR (tr|R7QHX8) Stackhouse genomic scaffold, scaffold_4...   355   1e-95
G9KUN2_MUSPF (tr|G9KUN2) Topoisomerase II alpha 170kDa (Fragment...   355   1e-95
G8BRR7_TETPH (tr|G8BRR7) DNA topoisomerase 2 OS=Tetrapisispora p...   355   1e-95
Q76C43_9EURO (tr|Q76C43) DNA topoisomerase 2 (Fragment) OS=Arthr...   355   1e-95
C0NX13_AJECG (tr|C0NX13) DNA topoisomerase 2 OS=Ajellomyces caps...   355   1e-95
G1LN78_AILME (tr|G1LN78) DNA topoisomerase 2 OS=Ailuropoda melan...   355   2e-95
F2SCP4_TRIRC (tr|F2SCP4) DNA topoisomerase 2 OS=Trichophyton rub...   355   2e-95
G1SDX3_RABIT (tr|G1SDX3) DNA topoisomerase 2 (Fragment) OS=Oryct...   355   2e-95
Q5PQY4_DANRE (tr|Q5PQY4) DNA topoisomerase 2 OS=Danio rerio GN=t...   355   2e-95
G0V250_TRYCI (tr|G0V250) DNA topoisomerase 2 OS=Trypanosoma cong...   355   2e-95
A0FCQ0_TRYCO (tr|A0FCQ0) DNA topoisomerase 2 OS=Trypanosoma cong...   355   2e-95
Q8CCE5_MOUSE (tr|Q8CCE5) Putative uncharacterized protein (Fragm...   355   2e-95
Q8X1U4_ASPNG (tr|Q8X1U4) DNA topoisomerase 2 (Fragment) OS=Asper...   355   2e-95
M3YTB1_MUSPF (tr|M3YTB1) DNA topoisomerase 2 OS=Mustela putorius...   355   2e-95
G0WCR2_NAUDC (tr|G0WCR2) DNA topoisomerase 2 OS=Naumovozyma dair...   355   2e-95
A6RG78_AJECN (tr|A6RG78) DNA topoisomerase 2 OS=Ajellomyces caps...   355   2e-95
F2PYI8_TRIEC (tr|F2PYI8) DNA topoisomerase 2 OS=Trichophyton equ...   355   2e-95
G1SIE2_RABIT (tr|G1SIE2) DNA topoisomerase 2 OS=Oryctolagus cuni...   355   2e-95
E3LH66_CAERE (tr|E3LH66) DNA topoisomerase 2 OS=Caenorhabditis r...   355   2e-95
G1L1L3_AILME (tr|G1L1L3) DNA topoisomerase 2 (Fragment) OS=Ailur...   355   2e-95
F1PRA7_CANFA (tr|F1PRA7) DNA topoisomerase 2 (Fragment) OS=Canis...   355   2e-95
D4DAV0_TRIVH (tr|D4DAV0) DNA topoisomerase 2 OS=Trichophyton ver...   355   2e-95
F2S2F0_TRIT1 (tr|F2S2F0) DNA topoisomerase 2 OS=Trichophyton ton...   355   2e-95
G1U773_RABIT (tr|G1U773) DNA topoisomerase 2 OS=Oryctolagus cuni...   355   2e-95
F7FGH6_ORNAN (tr|F7FGH6) DNA topoisomerase 2 OS=Ornithorhynchus ...   354   2e-95
H9GEY4_ANOCA (tr|H9GEY4) DNA topoisomerase 2 OS=Anolis carolinen...   354   2e-95
Q8J2R9_TRIVO (tr|Q8J2R9) DNA topoisomerase 2 (Fragment) OS=Trich...   354   2e-95
M3WBT9_FELCA (tr|M3WBT9) DNA topoisomerase 2 OS=Felis catus GN=T...   354   3e-95
H2WBZ3_CAEJA (tr|H2WBZ3) DNA topoisomerase 2 OS=Caenorhabditis j...   354   3e-95
L2GVJ4_VAVCU (tr|L2GVJ4) DNA topoisomerase 2 OS=Vavraia culicis ...   354   3e-95
G3UIA0_LOXAF (tr|G3UIA0) DNA topoisomerase 2 OS=Loxodonta africa...   354   3e-95
B8C9L4_THAPS (tr|B8C9L4) DNA topoisomerase 2 OS=Thalassiosira ps...   354   3e-95
F2T3U6_AJEDA (tr|F2T3U6) DNA topoisomerase 2 OS=Ajellomyces derm...   354   3e-95
C5GEX1_AJEDR (tr|C5GEX1) DNA topoisomerase 2 OS=Ajellomyces derm...   354   3e-95
G5E707_LOXAF (tr|G5E707) DNA topoisomerase 2 (Fragment) OS=Loxod...   354   3e-95
O55078_CRILO (tr|O55078) DNA topoisomerase 2 OS=Cricetulus longi...   354   3e-95
H0V8L7_CAVPO (tr|H0V8L7) DNA topoisomerase 2 OS=Cavia porcellus ...   354   3e-95
D0MV61_PHYIT (tr|D0MV61) DNA topoisomerase 2 OS=Phytophthora inf...   354   3e-95
Q76C33_TRIVC (tr|Q76C33) DNA topoisomerase 2 (Fragment) OS=Trich...   354   3e-95
Q8J2S0_9EURO (tr|Q8J2S0) DNA topoisomerase 2 (Fragment) OS=Trich...   354   3e-95
G3T1I5_LOXAF (tr|G3T1I5) DNA topoisomerase 2 (Fragment) OS=Loxod...   354   3e-95
H8XX09_TRYRA (tr|H8XX09) DNA topoisomerase 2 OS=Trypanosoma rang...   354   4e-95
L0AWF0_BABEQ (tr|L0AWF0) DNA topoisomerase 2 OS=Babesia equi GN=...   354   4e-95
Q9DFB7_CHICK (tr|Q9DFB7) DNA topoisomerase 2 OS=Gallus gallus GN...   354   4e-95
Q76C31_ARTBE (tr|Q76C31) DNA topoisomerase 2 (Fragment) OS=Arthr...   354   4e-95
Q76C38_9EURO (tr|Q76C38) DNA topoisomerase 2 (Fragment) OS=Trich...   354   4e-95
Q76C34_TRITO (tr|Q76C34) DNA topoisomerase 2 (Fragment) OS=Trich...   353   4e-95
Q76C32_ARTBE (tr|Q76C32) DNA topoisomerase 2 (Fragment) OS=Arthr...   353   4e-95
Q76C37_9EURO (tr|Q76C37) DNA topoisomerase 2 (Fragment) OS=Trich...   353   4e-95
Q5REX2_PONAB (tr|Q5REX2) DNA topoisomerase 2 OS=Pongo abelii GN=...   353   4e-95
I3M4Z3_SPETR (tr|I3M4Z3) DNA topoisomerase 2 OS=Spermophilus tri...   353   4e-95
C5K1W3_AJEDS (tr|C5K1W3) DNA topoisomerase 2 OS=Ajellomyces derm...   353   4e-95
I3NGU9_SPETR (tr|I3NGU9) DNA topoisomerase 2 OS=Spermophilus tri...   353   4e-95
I8I908_ASPO3 (tr|I8I908) DNA topoisomerase 2 OS=Aspergillus oryz...   353   4e-95
G3RZ97_GORGO (tr|G3RZ97) DNA topoisomerase 2 OS=Gorilla gorilla ...   353   5e-95
D4AZ93_ARTBC (tr|D4AZ93) DNA topoisomerase 2 OS=Arthroderma benh...   353   5e-95
M4AA94_XIPMA (tr|M4AA94) DNA topoisomerase 2 OS=Xiphophorus macu...   353   5e-95
Q76C35_9EURO (tr|Q76C35) DNA topoisomerase 2 (Fragment) OS=Arthr...   353   5e-95
Q8X1U5_ASPFM (tr|Q8X1U5) DNA topoisomerase 2 (Fragment) OS=Neosa...   353   5e-95
Q4WLF7_ASPFU (tr|Q4WLF7) DNA topoisomerase 2 OS=Neosartorya fumi...   353   5e-95
B0XM58_ASPFC (tr|B0XM58) DNA topoisomerase 2 OS=Neosartorya fumi...   353   5e-95
G0VIC6_NAUCC (tr|G0VIC6) DNA topoisomerase 2 OS=Naumovozyma cast...   353   6e-95
Q8X1U0_TALFL (tr|Q8X1U0) DNA topoisomerase 2 (Fragment) OS=Talar...   353   6e-95
B8NXR4_ASPFN (tr|B8NXR4) DNA topoisomerase 2 OS=Aspergillus flav...   353   6e-95
B6K4K4_SCHJY (tr|B6K4K4) DNA topoisomerase 2 OS=Schizosaccharomy...   353   6e-95
G3RAE1_GORGO (tr|G3RAE1) DNA topoisomerase 2 OS=Gorilla gorilla ...   353   7e-95
G3S3V9_GORGO (tr|G3S3V9) DNA topoisomerase 2 OS=Gorilla gorilla ...   353   7e-95
F0VN61_NEOCL (tr|F0VN61) DNA topoisomerase 2 OS=Neospora caninum...   353   7e-95
H2QCW5_PANTR (tr|H2QCW5) DNA topoisomerase 2 (Fragment) OS=Pan t...   353   7e-95
A8WTL4_CAEBR (tr|A8WTL4) DNA topoisomerase 2 OS=Caenorhabditis b...   353   7e-95
G4ZH94_PHYSP (tr|G4ZH94) DNA topoisomerase 2 OS=Phytophthora soj...   353   8e-95
K7BYJ3_PANTR (tr|K7BYJ3) DNA topoisomerase 2 OS=Pan troglodytes ...   353   8e-95
A0C0L0_PARTE (tr|A0C0L0) DNA topoisomerase 2 OS=Paramecium tetra...   353   8e-95
G7X785_ASPKW (tr|G7X785) DNA topoisomerase 2 OS=Aspergillus kawa...   353   8e-95
Q76C30_ARTBE (tr|Q76C30) DNA topoisomerase 2 (Fragment) OS=Arthr...   353   8e-95
Q2TY87_ASPOR (tr|Q2TY87) DNA topoisomerase 2 OS=Aspergillus oryz...   353   8e-95
F1RS45_PIG (tr|F1RS45) DNA topoisomerase 2 OS=Sus scrofa PE=2 SV=2    352   9e-95
L5JRH2_PTEAL (tr|L5JRH2) DNA topoisomerase 2 OS=Pteropus alecto ...   352   1e-94
K1Q404_CRAGI (tr|K1Q404) DNA topoisomerase 2 OS=Crassostrea giga...   352   1e-94
H2NU77_PONAB (tr|H2NU77) DNA topoisomerase 2 (Fragment) OS=Pongo...   352   1e-94
B8C9P0_THAPS (tr|B8C9P0) DNA topoisomerase 2 (Fragment) OS=Thala...   352   1e-94
Q8X1U6_ASPFL (tr|Q8X1U6) DNA topoisomerase 2 (Fragment) OS=Asper...   352   1e-94
Q755V8_ASHGO (tr|Q755V8) DNA topoisomerase 2 OS=Ashbya gossypii ...   352   1e-94
M9N6G3_ASHGS (tr|M9N6G3) FAER410Wp OS=Ashbya gossypii FDAG1 GN=F...   352   1e-94
I2H4V9_TETBL (tr|I2H4V9) DNA topoisomerase 2 OS=Tetrapisispora b...   352   1e-94
H8WZH4_CANO9 (tr|H8WZH4) DNA topoisomerase 2 OS=Candida orthopsi...   352   1e-94
B9U3G7_9AGAR (tr|B9U3G7) DNA topoisomerase 2 (Fragment) OS=Pleur...   351   2e-94
J3KAE2_COCIM (tr|J3KAE2) DNA topoisomerase 2 OS=Coccidioides imm...   351   2e-94
H3GJQ6_PHYRM (tr|H3GJQ6) DNA topoisomerase 2 OS=Phytophthora ram...   351   2e-94
E5SB63_TRISP (tr|E5SB63) DNA topoisomerase 2 OS=Trichinella spir...   351   2e-94
M3HI84_CANMA (tr|M3HI84) DNA topoisomerase 2 OS=Candida maltosa ...   351   3e-94
F6T9B4_CALJA (tr|F6T9B4) DNA topoisomerase 2 OS=Callithrix jacch...   350   3e-94
F6ZPV6_XENTR (tr|F6ZPV6) DNA topoisomerase 2 OS=Xenopus tropical...   350   4e-94
F6S0Y0_CALJA (tr|F6S0Y0) DNA topoisomerase 2 OS=Callithrix jacch...   350   4e-94
Q4DE53_TRYCC (tr|Q4DE53) DNA topoisomerase 2 OS=Trypanosoma cruz...   350   4e-94
E9DFV8_COCPS (tr|E9DFV8) DNA topoisomerase 2 OS=Coccidioides pos...   350   4e-94
C5P1Z4_COCP7 (tr|C5P1Z4) DNA topoisomerase 2 OS=Coccidioides pos...   350   4e-94
K2PB88_TRYCR (tr|K2PB88) DNA topoisomerase 2 OS=Trypanosoma cruz...   350   4e-94
K1VKL9_TRIAC (tr|K1VKL9) DNA topoisomerase 2 OS=Trichosporon asa...   350   5e-94
J5Q6D7_TRIAS (tr|J5Q6D7) DNA topoisomerase 2 OS=Trichosporon asa...   350   5e-94
Q4D8L4_TRYCC (tr|Q4D8L4) DNA topoisomerase 2 OS=Trypanosoma cruz...   350   6e-94
C8ZGE3_YEAS8 (tr|C8ZGE3) DNA topoisomerase 2 OS=Saccharomyces ce...   350   6e-94
E9P8H8_YEASX (tr|E9P8H8) DNA topoisomerase 2 OS=Saccharomyces ce...   350   6e-94
B3LNU7_YEAS1 (tr|B3LNU7) DNA topoisomerase 2 OS=Saccharomyces ce...   350   6e-94
N6T8X6_9CUCU (tr|N6T8X6) Uncharacterized protein (Fragment) OS=D...   350   7e-94
E9P8H0_YEASX (tr|E9P8H0) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
C7GUN8_YEAS2 (tr|C7GUN8) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
Q7LMA0_YEASX (tr|Q7LMA0) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
N1NXH6_YEASX (tr|N1NXH6) Top2p OS=Saccharomyces cerevisiae CEN.P...   350   7e-94
E9P8H4_YEASX (tr|E9P8H4) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
A6ZRZ2_YEAS7 (tr|A6ZRZ2) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
E9P8H5_YEASX (tr|E9P8H5) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
G2WM16_YEASK (tr|G2WM16) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
E9P8G9_YEASX (tr|E9P8G9) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
E9P8H2_YEASX (tr|E9P8H2) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
E9P8H7_YEASX (tr|E9P8H7) DNA topoisomerase 2 OS=Saccharomyces ce...   350   7e-94
B6K8S1_TOXGO (tr|B6K8S1) DNA topoisomerase 2 OS=Toxoplasma gondi...   349   1e-93
D8MBJ7_BLAHO (tr|D8MBJ7) DNA topoisomerase 2 OS=Blastocystis hom...   349   1e-93
K4DSZ3_TRYCR (tr|K4DSZ3) DNA topoisomerase 2 OS=Trypanosoma cruz...   349   1e-93
B9PK68_TOXGO (tr|B9PK68) DNA topoisomerase 2 OS=Toxoplasma gondi...   349   1e-93
Q6DRC7_DANRE (tr|Q6DRC7) DNA topoisomerase 2 OS=Danio rerio GN=t...   348   2e-93
G0S8N4_CHATD (tr|G0S8N4) DNA topoisomerase 2 OS=Chaetomium therm...   348   2e-93
B6HPI3_PENCW (tr|B6HPI3) DNA topoisomerase 2 OS=Penicillium chry...   348   2e-93
M7BE62_CHEMY (tr|M7BE62) DNA topoisomerase 2-alpha OS=Chelonia m...   348   2e-93
B9U3G6_PLEDJ (tr|B9U3G6) DNA topoisomerase 2 (Fragment) OS=Pleur...   348   3e-93
B4N154_DROWI (tr|B4N154) DNA topoisomerase 2 OS=Drosophila willi...   348   3e-93
H2Z120_CIOSA (tr|H2Z120) DNA topoisomerase 2 (Fragment) OS=Ciona...   347   4e-93
B9U3F3_9AGAR (tr|B9U3F3) DNA topoisomerase 2 (Fragment) OS=Pleur...   347   4e-93
E7A2Y1_SPORE (tr|E7A2Y1) DNA topoisomerase 2 OS=Sporisorium reil...   347   5e-93
C5KAQ6_PERM5 (tr|C5KAQ6) DNA topoisomerase 2 OS=Perkinsus marinu...   347   5e-93
H2Z122_CIOSA (tr|H2Z122) DNA topoisomerase 2 (Fragment) OS=Ciona...   347   6e-93
B9U3G2_9AGAR (tr|B9U3G2) Topoisomerase II (Fragment) OS=Pleurotu...   346   7e-93
Q8X1U3_PENCH (tr|Q8X1U3) DNA topoisomerase 2 (Fragment) OS=Penic...   346   8e-93
B9U3G5_9AGAR (tr|B9U3G5) DNA topoisomerase 2 (Fragment) OS=Pleur...   346   8e-93
H9JQ10_BOMMO (tr|H9JQ10) DNA topoisomerase 2 OS=Bombyx mori GN=T...   346   8e-93
F0WWU7_9STRA (tr|F0WWU7) DNA topoisomerase 2 OS=Albugo laibachii...   345   1e-92
B4KIH0_DROMO (tr|B4KIH0) DNA topoisomerase 2 OS=Drosophila mojav...   345   1e-92
J8PZX9_SACAR (tr|J8PZX9) DNA topoisomerase 2 OS=Saccharomyces ar...   345   1e-92
H2Z116_CIOSA (tr|H2Z116) DNA topoisomerase 2 OS=Ciona savignyi P...   345   1e-92
B3RRE6_TRIAD (tr|B3RRE6) DNA topoisomerase 2 (Fragment) OS=Trich...   345   2e-92
B4M8I9_DROVI (tr|B4M8I9) DNA topoisomerase 2 OS=Drosophila viril...   345   2e-92
Q8J2S7_9EURO (tr|Q8J2S7) DNA topoisomerase 2 (Fragment) OS=Asper...   345   2e-92
H2Z117_CIOSA (tr|H2Z117) DNA topoisomerase 2 (Fragment) OS=Ciona...   345   2e-92
B9U3F7_PLEER (tr|B9U3F7) DNA topoisomerase 2 (Fragment) OS=Pleur...   344   3e-92
B9U3G1_PLEER (tr|B9U3G1) DNA topoisomerase 2 (Fragment) OS=Pleur...   344   3e-92
G8ZS14_TORDC (tr|G8ZS14) DNA topoisomerase 2 OS=Torulaspora delb...   344   3e-92
B4GWX0_DROPE (tr|B4GWX0) DNA topoisomerase 2 OS=Drosophila persi...   344   4e-92
B9U3G3_PLECO (tr|B9U3G3) DNA topoisomerase 2 (Fragment) OS=Pleur...   344   4e-92
Q6C7Z9_YARLI (tr|Q6C7Z9) DNA topoisomerase 2 OS=Yarrowia lipolyt...   343   5e-92
K9FXX9_PEND1 (tr|K9FXX9) DNA topoisomerase 2 OS=Penicillium digi...   343   5e-92
K9FFX4_PEND2 (tr|K9FFX4) DNA topoisomerase 2 OS=Penicillium digi...   343   5e-92
Q29K53_DROPS (tr|Q29K53) DNA topoisomerase 2 OS=Drosophila pseud...   343   6e-92
F0ZB94_DICPU (tr|F0ZB94) DNA topoisomerase 2 OS=Dictyostelium pu...   343   6e-92
L8H0X6_ACACA (tr|L8H0X6) DNA topoisomerase 2 OS=Acanthamoeba cas...   343   6e-92
G0R9R6_HYPJQ (tr|G0R9R6) DNA topoisomerase 2 OS=Hypocrea jecorin...   343   6e-92
J7RDX4_KAZNA (tr|J7RDX4) DNA topoisomerase 2 OS=Kazachstania nag...   343   6e-92

>I1L9S4_SOYBN (tr|I1L9S4) DNA topoisomerase 2 OS=Glycine max PE=3 SV=2
          Length = 1459

 Score =  461 bits (1185), Expect = e-127,   Method: Compositional matrix adjust.
 Identities = 217/367 (59%), Positives = 281/367 (76%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M MADQD+DGSHIKGLLINF +   PSLL++P F+ E  TPIIRAFH NG 
Sbjct: 521 VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 580

Query: 61  QKLSFYSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
            KLSFYS PEYE W ++ GN+   W+IKYYKGLG+ T +EG+E+FQ+++  +K FVW ++
Sbjct: 581 -KLSFYSMPEYESWRESLGNNANGWKIKYYKGLGTSTPQEGREYFQDLDKHKKDFVWDDE 639

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D  AI +AFSK K  +R+  +  F+    RD+    I Y+DF+ KE ILYS A ++R I
Sbjct: 640 QDGGAIEMAFSKKKAEDRKIWIRNFEPGTCRDHMAKYINYRDFVNKELILYSRADLQRSI 699

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FK++LF EI+V + IGYV+EHSAYHH E SLA+T++ MA+D+
Sbjct: 700 PSMVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIINMAQDF 759

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL  NGQFGT   GGKDHAS RYIYTEL+ I+R +F E D+KLL+YLNEDG  
Sbjct: 760 VGSNNINLLKPNGQFGTRNLGGKDHASARYIYTELSTITRCIFHEDDDKLLEYLNEDGRC 819

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+P+IPLVLVNG  GI TGW+  IP YNP+DIIAN++R L+ + + PM PWYKGF
Sbjct: 820 IEPTWYIPVIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLSGETMVPMDPWYKGF 879

Query: 359 KGTIDKS 365
           KGTI++S
Sbjct: 880 KGTIERS 886


>I1MJQ7_SOYBN (tr|I1MJQ7) DNA topoisomerase 2 OS=Glycine max PE=3 SV=2
          Length = 1484

 Score =  458 bits (1179), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 216/367 (58%), Positives = 280/367 (76%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M MADQD+DGSHIKGLLINF +   PSLL++P F+ E  TPIIRAFH NG 
Sbjct: 522 VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 581

Query: 61  QKLSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
            KLSFYS PEYE W ++ GN  + W+IKYYKGLG+ T +EG+E+F++++  +K FVW ++
Sbjct: 582 -KLSFYSMPEYESWRESLGNNATGWKIKYYKGLGTSTPQEGREYFRDLDKHKKDFVWDDE 640

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D  AI +AFSK K  +R+  +  F+    RD+    I Y+DF+ KE ILYS A ++R I
Sbjct: 641 QDGGAIEMAFSKKKAEDRKIWIRNFEPGTCRDHMAKYINYRDFVNKELILYSRADLQRSI 700

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FK++L  EI+V + IGYV+EHSAYHH E SLA+T++ MA+D+
Sbjct: 701 PSMVDGLKPGQRKILFCSFKKKLSKEIKVGQFIGYVSEHSAYHHGEQSLASTIINMAQDF 760

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL  NGQFGT   GGKDHAS RYIYTELN I+R +F E D+KLL+YLNEDG  
Sbjct: 761 VGSNNINLLKPNGQFGTRNLGGKDHASARYIYTELNTITRCIFHEDDDKLLEYLNEDGRC 820

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+P+IPLVLVNG  GI TGW+  IP YNP+DIIAN++R L+ + + PM PWYKGF
Sbjct: 821 IEPNWYIPVIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLSGETMVPMDPWYKGF 880

Query: 359 KGTIDKS 365
           KGTI++S
Sbjct: 881 KGTIERS 887


>F6HBC4_VITVI (tr|F6HBC4) DNA topoisomerase 2 OS=Vitis vinifera
           GN=VIT_13s0064g00560 PE=3 SV=1
          Length = 1489

 Score =  458 bits (1179), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 214/367 (58%), Positives = 278/367 (75%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPI++A H NG 
Sbjct: 520 IKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHRNG- 578

Query: 61  QKLSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + LSFYS PEYE W ++ G   S W IKYYKGLG+ T +EGKE+F+++   +K F+W ++
Sbjct: 579 RVLSFYSMPEYESWKESLGGNASGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFMWVDE 638

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D DAI +AFSK K  ER+  + +F+   Y D  +  I Y DF+ KE IL+SMA ++R I
Sbjct: 639 KDGDAIELAFSKKKIEERKNWLRQFQPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSI 698

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FKR    E ++ +  GYV+EHSAYHH E SLA+T++ MA+D+
Sbjct: 699 PSMVDGLKPGQRKILFCSFKRNFIKEAKIAQFSGYVSEHSAYHHGEQSLASTIIGMAQDF 758

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL+ NGQFGT  QGGKDHAS RYIYT L+PI+RFLFP+ D+ LL YLNEDG S
Sbjct: 759 VGSNNINLLLPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQS 818

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+P IP+VLVNG  GI TGW+ SIP YNP+DIIAN++R LN + ++PM PWY+GF
Sbjct: 819 IEPTWYVPTIPMVLVNGSEGIGTGWSSSIPNYNPRDIIANVRRLLNGEMMEPMDPWYRGF 878

Query: 359 KGTIDKS 365
           +GTI+K+
Sbjct: 879 RGTIEKT 885


>M1A903_SOLTU (tr|M1A903) DNA topoisomerase 2 OS=Solanum tuberosum
           GN=PGSC0003DMG400006793 PE=3 SV=1
          Length = 1487

 Score =  453 bits (1165), Expect = e-125,   Method: Compositional matrix adjust.
 Identities = 206/367 (56%), Positives = 278/367 (75%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A H +G 
Sbjct: 517 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSG- 575

Query: 61  QKLSFYSYPEYEKWWKNWG--NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + L+FY+ PEYE W ++ G  +S W IKYYKGLG+ T +EGKE+FQ+++  RK F+W ++
Sbjct: 576 RILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADN 635

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D ++I +AFSK K   R+  + +F+   + D  +  I Y +F+ KE IL+SMA ++R I
Sbjct: 636 QDGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSI 695

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFKR    E +V +  GYV+EHSAYHH E SL++T++ MA+DY
Sbjct: 696 PSMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDY 755

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL  NGQFGT   GGKDHAS RYIYT L+PI+RFLFP+ D+ +L YLNEDG S
Sbjct: 756 VGSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQS 815

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP+VLVNG  GI TGW+  +P YNP+D++AN++R LND+ ++PM PWYKGF
Sbjct: 816 IEPTWYIPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGF 875

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 876 KGTIEKT 882


>M1A904_SOLTU (tr|M1A904) DNA topoisomerase 2 OS=Solanum tuberosum
           GN=PGSC0003DMG400006793 PE=3 SV=1
          Length = 1486

 Score =  452 bits (1164), Expect = e-125,   Method: Compositional matrix adjust.
 Identities = 206/367 (56%), Positives = 278/367 (75%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A H +G 
Sbjct: 517 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSG- 575

Query: 61  QKLSFYSYPEYEKWWKNWG--NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + L+FY+ PEYE W ++ G  +S W IKYYKGLG+ T +EGKE+FQ+++  RK F+W ++
Sbjct: 576 RILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADN 635

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D ++I +AFSK K   R+  + +F+   + D  +  I Y +F+ KE IL+SMA ++R I
Sbjct: 636 QDGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSI 695

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFKR    E +V +  GYV+EHSAYHH E SL++T++ MA+DY
Sbjct: 696 PSMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDY 755

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL  NGQFGT   GGKDHAS RYIYT L+PI+RFLFP+ D+ +L YLNEDG S
Sbjct: 756 VGSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQS 815

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP+VLVNG  GI TGW+  +P YNP+D++AN++R LND+ ++PM PWYKGF
Sbjct: 816 IEPTWYIPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGF 875

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 876 KGTIEKT 882


>M1A902_SOLTU (tr|M1A902) DNA topoisomerase 2 OS=Solanum tuberosum
           GN=PGSC0003DMG400006793 PE=3 SV=1
          Length = 1407

 Score =  452 bits (1163), Expect = e-124,   Method: Compositional matrix adjust.
 Identities = 206/367 (56%), Positives = 278/367 (75%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A H +G 
Sbjct: 517 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSG- 575

Query: 61  QKLSFYSYPEYEKWWKNWG--NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + L+FY+ PEYE W ++ G  +S W IKYYKGLG+ T +EGKE+FQ+++  RK F+W ++
Sbjct: 576 RILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADN 635

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D ++I +AFSK K   R+  + +F+   + D  +  I Y +F+ KE IL+SMA ++R I
Sbjct: 636 QDGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSI 695

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFKR    E +V +  GYV+EHSAYHH E SL++T++ MA+DY
Sbjct: 696 PSMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDY 755

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL  NGQFGT   GGKDHAS RYIYT L+PI+RFLFP+ D+ +L YLNEDG S
Sbjct: 756 VGSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQS 815

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP+VLVNG  GI TGW+  +P YNP+D++AN++R LND+ ++PM PWYKGF
Sbjct: 816 IEPTWYIPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGF 875

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 876 KGTIEKT 882


>K4AYE0_SOLLC (tr|K4AYE0) DNA topoisomerase 2 OS=Solanum lycopersicum
           GN=Solyc01g087500.2 PE=3 SV=1
          Length = 1478

 Score =  449 bits (1154), Expect = e-124,   Method: Compositional matrix adjust.
 Identities = 205/367 (55%), Positives = 276/367 (75%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A H +G 
Sbjct: 517 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSG- 575

Query: 61  QKLSFYSYPEYEKWWKNWG--NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + L+FY+ PEYE W ++ G  +S W IKYYKGLG+ T +EGKE+FQ+++  RK FVW ++
Sbjct: 576 RILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADN 635

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D ++I +AFSK K   R+  + +F+   + D  +  I Y +F+ KE IL+SMA ++R I
Sbjct: 636 QDGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSI 695

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFKR    E +V +  GYV+EHSAYHH E SL++T++ MA+DY
Sbjct: 696 PSMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDY 755

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL  NGQFGT   GGKDHAS RYIYT L+PI+RFLFP+ D+ +L YLNEDG S
Sbjct: 756 VGSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQS 815

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+P+IP VLVNG  GI TGW+  +P YNP+D++AN++R LND+ ++PM PWYKGF
Sbjct: 816 IEPTWYVPVIPTVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGF 875

Query: 359 KGTIDKS 365
           KG I+K+
Sbjct: 876 KGKIEKT 882


>Q8GSC4_TOBAC (tr|Q8GSC4) DNA topoisomerase 2 OS=Nicotiana tabacum PE=2 SV=1
          Length = 1482

 Score =  448 bits (1153), Expect = e-123,   Method: Compositional matrix adjust.
 Identities = 204/367 (55%), Positives = 276/367 (75%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A H +G 
Sbjct: 516 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSG- 574

Query: 61  QKLSFYSYPEYEKWWKNWG--NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + LSFY+ PEYE W K+ G  +S W IKYYKGLG+ T +EGKE+FQ+++  RK F+W ++
Sbjct: 575 KILSFYTMPEYESWRKSLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADN 634

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D ++I +AFSK K   R+  + +F+   + D  +  I Y +F+ KE IL+SMA ++R I
Sbjct: 635 QDGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSI 694

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFKR    E +V +  GYV+EHSAYHH E SL++T++ MA+DY
Sbjct: 695 PSMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDY 754

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL  NGQFGT   GGKDHAS RYIYT L+PI+RFLFP+ D+ +  YLNEDG  
Sbjct: 755 VGSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTIHDYLNEDGQY 814

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PI+P+VL+NG  GI TGW+  +P YNP+D++AN++R LND+ ++PM PWYKGF
Sbjct: 815 IEPTWYVPIVPMVLINGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGF 874

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 875 KGTIEKT 881


>M5X8I4_PRUPE (tr|M5X8I4) Uncharacterized protein OS=Prunus persica
           GN=PRUPE_ppa000202mg PE=4 SV=1
          Length = 1471

 Score =  448 bits (1152), Expect = e-123,   Method: Compositional matrix adjust.
 Identities = 211/368 (57%), Positives = 275/368 (74%), Gaps = 3/368 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPI++A H NG 
Sbjct: 523 LKSLRYGSLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNG- 581

Query: 61  QKLSFYSYPEYEKWWKNW-GN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + L+FYS PEYE W ++  GN S W IKYYKGLG+ T +EG+++FQN+ + +K F+W ++
Sbjct: 582 KSLAFYSMPEYEAWKESLRGNASGWSIKYYKGLGTSTSKEGRDYFQNLAMHKKDFIWIDE 641

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
            D +AI +AFSK K  ER+  + +F+ S + D  +  I Y DF+ KE I +SMA ++R I
Sbjct: 642 RDGEAIELAFSKKKIEERKNWLRQFEPSVHLDQKEKLIKYSDFVHKELIQFSMADLQRSI 701

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FKR    E +V +  GYV+EHSAYHH E SLA+T++ MA+DY
Sbjct: 702 PSMVDGLKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDY 761

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL  NGQFGT   GGKDHAS RYIYT L+PI+RFLFP+ D++LL YLNEDG S
Sbjct: 762 VGSNNINLLQPNGQFGTRNLGGKDHASARYIYTRLSPITRFLFPKDDDRLLDYLNEDGQS 821

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP VLVNG  GI TGW+  IP YN +DI+AN++R LN + + PM PWY+GF
Sbjct: 822 IEPTWYVPIIPTVLVNGSEGIGTGWSSYIPNYNTRDIVANVRRLLNGEAMVPMDPWYRGF 881

Query: 359 KGTIDKSI 366
            GTI+K++
Sbjct: 882 SGTIEKTV 889


>B9RVN3_RICCO (tr|B9RVN3) DNA topoisomerase II, putative OS=Ricinus communis
           GN=RCOM_0966810 PE=4 SV=1
          Length = 1212

 Score =  441 bits (1134), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 210/362 (58%), Positives = 273/362 (75%), Gaps = 3/362 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLINF Y   PSLL+IP FL E ITPI++A H +G + LSF
Sbjct: 240 YGHLMIMTDQDYDGSHIKGLLINFIYYFWPSLLKIPSFLVEFITPIVKATHRSG-KILSF 298

Query: 66  YSYPEYEKWWKN-WGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ PEY  W ++  GN++ W IKYYKGLG+   +EG ++F++++  +K FVW N+ED  A
Sbjct: 299 YTMPEYYSWKESLMGNANGWTIKYYKGLGTNDKKEGMQYFRDIDKHQKDFVWMNEEDGTA 358

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK K  ER+  +  F+   + +  +  I Y DF+ KE IL+S+A ++R IPS++D
Sbjct: 359 IELAFSKKKVDERKNWLRHFQPGTHLEQKNKLIKYSDFINKELILFSVADLQRSIPSMVD 418

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP+QRKIL+  FKR L  +++V +L GYV+E SAYHH E SL +T++ MA+++VGS N
Sbjct: 419 GLKPAQRKILFSCFKRNLVKDLKVVQLQGYVSEQSAYHHGEQSLQSTIVGMAQNFVGSNN 478

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           INLL   GQFGT   GGKDHASPRYIYT L+PI+RFLFP+ D+ LL YL EDG+S+EP W
Sbjct: 479 INLLAPKGQFGTRCSGGKDHASPRYIYTCLSPITRFLFPKDDDCLLDYLQEDGLSIEPTW 538

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y PIIPLVLVNG  GI TGW+  IP YNP+DI+AN++RFLN +K++PM PWYKGFKGTI+
Sbjct: 539 YAPIIPLVLVNGCEGIGTGWSTFIPNYNPRDIVANLRRFLNGEKMEPMHPWYKGFKGTIE 598

Query: 364 KS 365
           KS
Sbjct: 599 KS 600


>M0T361_MUSAM (tr|M0T361) DNA topoisomerase 2 OS=Musa acuminata subsp.
           malaccensis PE=3 SV=1
          Length = 1449

 Score =  440 bits (1131), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 202/362 (55%), Positives = 268/362 (74%), Gaps = 2/362 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P F+ E ITP+++A +      LSF
Sbjct: 535 YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFMVEFITPLLKATNNKNKTVLSF 594

Query: 66  YSYPEYEKWWKNWG--NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           YS PEYE W ++ G  +S W IKYYKGLG+   EEGKE+F++++  +K FVW +++D +A
Sbjct: 595 YSMPEYEAWKESLGGNSSGWSIKYYKGLGTSKSEEGKEYFKDIDKHKKEFVWADEQDGNA 654

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK K   R+  + +F+  +Y D     I Y DF+ KE IL+S A ++R IPS++D
Sbjct: 655 IELAFSKKKIEARKNWLRQFEPDNYLDQKQKLIKYSDFINKELILFSRADLQRSIPSMVD 714

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+ AFKR    + +V + +GYV+E SAYHH E SL+TT++ MA+D+VGS N
Sbjct: 715 GLKPGQRKILFCAFKRNFVKQAKVAQFVGYVSEKSAYHHGEQSLSTTIIGMAQDFVGSNN 774

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           INLL+  GQFGT  QGGKDHAS RYI+T ++P++RFLF + D+ LL YLNEDG S+EP W
Sbjct: 775 INLLLPEGQFGTRHQGGKDHASARYIFTCMSPVTRFLFSKDDDILLDYLNEDGQSIEPTW 834

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+P+IP VLVNG  GI TGW+  +P YNPKDI+ANI+R LND+ +QPM PWY+GFKG I+
Sbjct: 835 YMPVIPTVLVNGSEGIGTGWSSYVPNYNPKDIVANIRRLLNDEPMQPMDPWYRGFKGRIE 894

Query: 364 KS 365
           KS
Sbjct: 895 KS 896


>Q4JF74_SCUBA (tr|Q4JF74) DNA topoisomerase 2 OS=Scutellaria baicalensis GN=TopII
           PE=2 SV=1
          Length = 1469

 Score =  437 bits (1125), Expect = e-120,   Method: Compositional matrix adjust.
 Identities = 204/362 (56%), Positives = 266/362 (73%), Gaps = 2/362 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL   ITPI++A H +G +KLSF
Sbjct: 533 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLLGFITPIVKARHKDGKRKLSF 592

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ P+YE W +  G    +W +KYYKGLG+ T +E  E+F ++    K FV+ + ED DA
Sbjct: 593 YTMPQYEAWKEAQGTEAKNWTVKYYKGLGTSTDQEAMEYFSDLGKHEKDFVYVDGEDDDA 652

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK K   R+G + +F+   + D  D  I Y+DF+ KE IL+S+A V+R IPS++D
Sbjct: 653 IELAFSKKKIEARKGWLRQFEPGTFLDDRDSHIKYRDFVHKELILFSIADVQRSIPSMVD 712

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+ +FKR    E +V +  GYV+EHSAYHH E SLA T++ MA+DYVGS N
Sbjct: 713 GLKPGQRKILFCSFKRNFVREAKVAQFSGYVSEHSAYHHGEQSLAGTIIGMAQDYVGSNN 772

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           INLL+  GQFGT  QGGKDHAS RY++T+L+P++RFLFP+ D+ LL YLNEDG S+EP W
Sbjct: 773 INLLLPIGQFGTRGQGGKDHASARYVFTQLSPVTRFLFPKADDILLDYLNEDGQSIEPTW 832

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PIIP+VLVNG  GI TGW+  +P YNP DIIANI+  LND+  +PM PWYKGF G+++
Sbjct: 833 YVPIIPMVLVNGSEGIGTGWSSYVPNYNPVDIIANIRHLLNDEATEPMHPWYKGFLGSVE 892

Query: 364 KS 365
           K+
Sbjct: 893 KT 894


>G7IWV9_MEDTR (tr|G7IWV9) DNA topoisomerase 2 OS=Medicago truncatula
           GN=MTR_3g031040 PE=3 SV=1
          Length = 1567

 Score =  436 bits (1121), Expect = e-120,   Method: Compositional matrix adjust.
 Identities = 216/417 (51%), Positives = 278/417 (66%), Gaps = 53/417 (12%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIR------- 53
           ++S  YG +M MADQD+DGSHIKGLLINF +   PSLL++P F+ E  TPIIR       
Sbjct: 526 VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRVSIINAV 585

Query: 54  -------------------------------------------AFHCNGIQKLSFYSYPE 70
                                                      A H NG  KLSFYS PE
Sbjct: 586 CCIFDNENTELYMPLSSRSLSVLILHLSLSLFFMMRYIYFAMQASHKNGT-KLSFYSMPE 644

Query: 71  YEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAINIAF 128
           Y+ W +  GN+   W IKYYKGLG+ T +EG+E+F++++  RK F+W N+ D +AI +AF
Sbjct: 645 YDAWRERLGNTANAWAIKYYKGLGTSTPQEGREYFKDLDKHRKDFIWENELDGNAIELAF 704

Query: 129 SKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQKPS 188
           SK K  +R+  M  F+    RD+    I YKDF+ KE IL+S A ++R IPS++DG KP 
Sbjct: 705 SKKKAEDRKNWMRSFEPGTCRDHEAKLISYKDFVDKELILFSRADLQRSIPSMVDGLKPG 764

Query: 189 QRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNINLLM 248
           QRKIL+ +FK+ L  E++V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS NINLL 
Sbjct: 765 QRKILFCSFKKNLSKEVKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLT 824

Query: 249 ANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYLPII 308
            NGQFGT   GGKDHAS RYIYT+LN ++R LF   D+KLL+YLNEDG S+EP WY+PII
Sbjct: 825 PNGQFGTRNLGGKDHASSRYIYTQLNTVTRSLFHADDDKLLEYLNEDGRSIEPNWYIPII 884

Query: 309 PLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDKS 365
           PLVLVNG  GI TGW+  IP YNP++IIAN++R LND+++ PM PWYKGF+GTI+KS
Sbjct: 885 PLVLVNGSEGIGTGWSSFIPNYNPREIIANVRRLLNDEEMVPMDPWYKGFRGTIEKS 941


>I1ICW7_BRADI (tr|I1ICW7) DNA topoisomerase 2 OS=Brachypodium distachyon
           GN=BRADI3G52470 PE=3 SV=1
          Length = 1490

 Score =  435 bits (1118), Expect = e-119,   Method: Compositional matrix adjust.
 Identities = 205/362 (56%), Positives = 261/362 (72%), Gaps = 2/362 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A +      +SF
Sbjct: 526 YGHLMIMTDQDHDGSHIKGLLINFIHSSWPSLLKVPSFLVEFITPIIKATNKRSKSVISF 585

Query: 66  YSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           YS P+YE W +  G   S W IKYYKGLG+ T +EG+E+F+ +   RK FVW +D+D DA
Sbjct: 586 YSMPDYEAWKERLGANASAWSIKYYKGLGTSTADEGREYFEKIAHHRKDFVWADDKDGDA 645

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK +  +R+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++D
Sbjct: 646 IELAFSKKRIADRKDWLSNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMVD 705

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+ +FKR L  EI+V + IGYV+EHSAYHH E SLA+T++ MA+DYVGS N
Sbjct: 706 GLKPGQRKILFSSFKRNLVKEIKVAQFIGYVSEHSAYHHGEQSLASTILGMAQDYVGSNN 765

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           I+LL   GQFGT   GGKD AS RYIYT L  I+R +FP+ D+ LL YLNEDG S+EP W
Sbjct: 766 ISLLEPRGQFGTRNSGGKDAASARYIYTRLPSITRIIFPKDDDVLLNYLNEDGQSIEPTW 825

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PIIP+VLVNG  GI TGW+   P YNP+DI+AN+KR LNDD + PM PWYKGFKG+ +
Sbjct: 826 YMPIIPMVLVNGSEGIGTGWSTYTPNYNPRDIVANLKRLLNDDPIVPMDPWYKGFKGSFE 885

Query: 364 KS 365
           K+
Sbjct: 886 KT 887


>I1ICW6_BRADI (tr|I1ICW6) DNA topoisomerase 2 OS=Brachypodium distachyon
           GN=BRADI3G52470 PE=3 SV=1
          Length = 1494

 Score =  434 bits (1117), Expect = e-119,   Method: Compositional matrix adjust.
 Identities = 205/362 (56%), Positives = 261/362 (72%), Gaps = 2/362 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A +      +SF
Sbjct: 526 YGHLMIMTDQDHDGSHIKGLLINFIHSSWPSLLKVPSFLVEFITPIIKATNKRSKSVISF 585

Query: 66  YSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           YS P+YE W +  G   S W IKYYKGLG+ T +EG+E+F+ +   RK FVW +D+D DA
Sbjct: 586 YSMPDYEAWKERLGANASAWSIKYYKGLGTSTADEGREYFEKIAHHRKDFVWADDKDGDA 645

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK +  +R+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++D
Sbjct: 646 IELAFSKKRIADRKDWLSNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMVD 705

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+ +FKR L  EI+V + IGYV+EHSAYHH E SLA+T++ MA+DYVGS N
Sbjct: 706 GLKPGQRKILFSSFKRNLVKEIKVAQFIGYVSEHSAYHHGEQSLASTILGMAQDYVGSNN 765

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           I+LL   GQFGT   GGKD AS RYIYT L  I+R +FP+ D+ LL YLNEDG S+EP W
Sbjct: 766 ISLLEPRGQFGTRNSGGKDAASARYIYTRLPSITRIIFPKDDDVLLNYLNEDGQSIEPTW 825

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PIIP+VLVNG  GI TGW+   P YNP+DI+AN+KR LNDD + PM PWYKGFKG+ +
Sbjct: 826 YMPIIPMVLVNGSEGIGTGWSTYTPNYNPRDIVANLKRLLNDDPIVPMDPWYKGFKGSFE 885

Query: 364 KS 365
           K+
Sbjct: 886 KT 887


>Q6Z8D9_ORYSJ (tr|Q6Z8D9) DNA topoisomerase 2 OS=Oryza sativa subsp. japonica
           GN=P0459B01.29 PE=2 SV=1
          Length = 1525

 Score =  431 bits (1109), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 203/363 (55%), Positives = 267/363 (73%), Gaps = 3/363 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ-KLS 64
           YG +M M DQD+DGSHIKGLLINF +   PSL++IP FL E ITPII+A +    +  L 
Sbjct: 529 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKRDKKIVLP 588

Query: 65  FYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
           FYS PEYE+W ++ G   S W IKYYKGLG+ T  EG+++FQ++   +K FVW+ND+D +
Sbjct: 589 FYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKNDQDDN 648

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I +AFSK +  +R+  +  F+S  + D     I Y DF+ KE I +SMA + R IPS++
Sbjct: 649 DIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRSIPSMV 708

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FKR L  EI+V +  GYV+EHSAYHH E SLA+T+  MA+D+VGS 
Sbjct: 709 DGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQDFVGSN 768

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL  NGQFGT  QGGKD AS RYI+T L+PI+R +FP+ D+ LL YL+EDG S+EP 
Sbjct: 769 NINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQSIEPT 828

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LND+ ++PM PWY+GFKG+I
Sbjct: 829 WYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRGFKGSI 888

Query: 363 DKS 365
            K+
Sbjct: 889 QKT 891


>I1P3D3_ORYGL (tr|I1P3D3) DNA topoisomerase 2 OS=Oryza glaberrima PE=3 SV=1
          Length = 1524

 Score =  431 bits (1109), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 203/363 (55%), Positives = 267/363 (73%), Gaps = 3/363 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ-KLS 64
           YG +M M DQD+DGSHIKGLLINF +   PSL++IP FL E ITPII+A +    +  L 
Sbjct: 529 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKRDKKIVLP 588

Query: 65  FYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
           FYS PEYE+W ++ G   S W IKYYKGLG+ T  EG+++FQ++   +K FVW+ND+D +
Sbjct: 589 FYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKNDQDDN 648

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I +AFSK +  +R+  +  F+S  + D     I Y DF+ KE I +SMA + R IPS++
Sbjct: 649 DIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRSIPSMV 708

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FKR L  EI+V +  GYV+EHSAYHH E SLA+T+  MA+D+VGS 
Sbjct: 709 DGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQDFVGSN 768

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL  NGQFGT  QGGKD AS RYI+T L+PI+R +FP+ D+ LL YL+EDG S+EP 
Sbjct: 769 NINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQSIEPT 828

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LND+ ++PM PWY+GFKG+I
Sbjct: 829 WYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRGFKGSI 888

Query: 363 DKS 365
            K+
Sbjct: 889 QKT 891


>Q2L363_MALDO (tr|Q2L363) DNA topoisomerase 2 OS=Malus domestica
           GN=Md49N23_TopII.010 PE=3 SV=1
          Length = 1467

 Score =  431 bits (1108), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 204/356 (57%), Positives = 264/356 (74%), Gaps = 3/356 (0%)

Query: 13  ADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSFYSYPEYE 72
           A QD+DGSHIKGLLINF +   PSLL+IP FL E ITPI++A H NG   L+FYS PEYE
Sbjct: 499 ATQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNG-NTLAFYSMPEYE 557

Query: 73  KWWKNW-GN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAINIAFSK 130
            W ++  GN S W IKYYKGLG+ T +EG+++FQN+   +K F+W ++ D +AI +AFSK
Sbjct: 558 AWKESLRGNASGWSIKYYKGLGTSTSKEGRDYFQNLVQHKKDFIWIDERDGEAIELAFSK 617

Query: 131 SKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQKPSQR 190
            K  ER+  + +F+   + D  +  I Y DF+ KE I +SMA ++R IPS++DG KP QR
Sbjct: 618 KKIEERKNWLRQFEPGVHLDQKEKLIKYSDFVHKELIQFSMADLQRSIPSMVDGLKPGQR 677

Query: 191 KILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNINLLMAN 250
           KIL+ +FKR    E +V +  GYV+EHSAYHH E SLA+T++ MA+D+VGS NINLL  N
Sbjct: 678 KILFSSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLQPN 737

Query: 251 GQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYLPIIPL 310
           GQFGT   GGKDHAS RYIYT L+PI+RFLF + D++LL YLNEDG S+EP WY+PIIP 
Sbjct: 738 GQFGTRNLGGKDHASARYIYTRLSPITRFLFSKDDDRLLDYLNEDGQSIEPTWYVPIIPT 797

Query: 311 VLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDKSI 366
           VLVNG  GI TGW+  IP YNP+DI+AN++R L+ D + PM PWY+GF GTI+K++
Sbjct: 798 VLVNGSEGIGTGWSSYIPNYNPRDIVANVRRLLDGDAMVPMDPWYRGFTGTIEKTV 853


>M4D3L7_BRARP (tr|M4D3L7) DNA topoisomerase 2 OS=Brassica rapa subsp. pekinensis
           GN=Bra011071 PE=3 SV=1
          Length = 1412

 Score =  430 bits (1105), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 204/367 (55%), Positives = 264/367 (71%), Gaps = 4/367 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGLLINF +   P+LL++P FL E ITPI++A   N +
Sbjct: 522 VNSLRYGHMMIMTDQDHDGSHIKGLLINFIHSFWPTLLKVPSFLVEFITPIVKATRKNEV 581

Query: 61  QKLSFYSYPEYEKWWKNW-GNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
             LSFYS PEYE W ++  GN+  W IKYYKGLG+ T +EGKE+F N++I +K FVW ++
Sbjct: 582 --LSFYSMPEYESWKESLSGNATGWTIKYYKGLGTSTSKEGKEYFGNLDIHKKDFVWEDE 639

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D +AI +AFSK K   R+  +  F+   + D     I + DF+ KE IL+SMA ++R I
Sbjct: 640 QDGEAIELAFSKKKIEARKNWLSHFEPGTHLDQKQQKISFSDFVNKELILFSMADLQRSI 699

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FKR    E +V +  GYV+EHSAYHH E SLA T++ MA+DY
Sbjct: 700 PSMVDGLKPGQRKILFCSFKRNFTKEAKVAQFSGYVSEHSAYHHGEQSLAGTIIGMAQDY 759

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL  NGQFGT   GGKD ASPRYI+T+L+  +R LFP+ D+ LL YLNEDG  
Sbjct: 760 VGSNNINLLQPNGQFGTRNMGGKDAASPRYIFTKLSSATRVLFPKDDDVLLNYLNEDGQK 819

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP VLVNG  GI TGW+  IP YNP+DI+ANI+R LN + +  M PWY+ F
Sbjct: 820 IEPTWYMPIIPTVLVNGSEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMVAMDPWYRNF 879

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 880 KGTIEKT 886


>K3YP99_SETIT (tr|K3YP99) DNA topoisomerase 2 OS=Setaria italica GN=Si016091m.g
           PE=3 SV=1
          Length = 1480

 Score =  430 bits (1105), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 202/362 (55%), Positives = 264/362 (72%), Gaps = 4/362 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A   N  +  SF
Sbjct: 520 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIIKATKKNETK--SF 577

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ PEYE W +N G S   W IKYYKGLG+ T +EGK++F N++  +K FVW +D+D + 
Sbjct: 578 YTMPEYEDWKRNLGASASSWTIKYYKGLGTSTSKEGKDYFTNIDQHKKDFVWVDDQDGNE 637

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK +  +R+  +  F+   Y D  +  I Y+DF+ KE IL+S+A ++R IPS++D
Sbjct: 638 IELAFSKKRIADRKEWLTNFQPGTYLDQREKEIKYRDFINKELILFSLADLQRSIPSMVD 697

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+ +FKR L  E +V +  GYV+EHSAYHH E SLA+T++ MA+ +VGS N
Sbjct: 698 GFKPGQRKILFCSFKRNLVKETKVAQFSGYVSEHSAYHHGEQSLASTIVGMAQSFVGSNN 757

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           INLL   GQFGT  QGGKD ASPRYI+T+L+ I+R +FP+ D+ LL YLNEDG  +EP W
Sbjct: 758 INLLYPGGQFGTRSQGGKDAASPRYIFTKLSHITRSIFPKDDDTLLNYLNEDGQLIEPSW 817

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PI+P+VLVNG  GI TGW+  IP YNP+DI ANI+R LND+   PM PWY+GFKG+I 
Sbjct: 818 YVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIAANIRRLLNDEATVPMHPWYRGFKGSIQ 877

Query: 364 KS 365
           K+
Sbjct: 878 KA 879


>J3LG54_ORYBR (tr|J3LG54) DNA topoisomerase 2 OS=Oryza brachyantha GN=OB02G36210
           PE=3 SV=1
          Length = 1506

 Score =  429 bits (1103), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 202/363 (55%), Positives = 265/363 (73%), Gaps = 3/363 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK-LS 64
           YG +M M DQD+DGSHIKGLLINF +   PSL++IP FL E ITPII+A +    +  L 
Sbjct: 532 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKRDKKNVLP 591

Query: 65  FYSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
           FYS PEYE+W ++ G +   W IKYYKGLG+ T  EG+++FQ++   +K FVW ND+D D
Sbjct: 592 FYSMPEYEQWKESLGGNARGWSIKYYKGLGTSTSTEGRQYFQDIAKHKKDFVWANDQDDD 651

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I +AFSK +  +R+  +  F+   Y D  D  I Y DF+ KE I +SMA + R IPS++
Sbjct: 652 NIELAFSKKRITDRKDWLSNFQPGTYLDQHDKYIKYSDFINKELIQFSMADLLRSIPSMV 711

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FKR L  E +V +  GYV+EHSAYHH E SLA+T+  MA+D+VGS 
Sbjct: 712 DGLKPGQRKILFCSFKRNLVKETKVAQFSGYVSEHSAYHHGEQSLASTITGMAQDFVGSN 771

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL+  GQFGT  QGGKD AS RYIYT+L PI+R +FP+ D+ LL YL+EDG S+EP 
Sbjct: 772 NINLLLPLGQFGTRDQGGKDAASARYIYTQLAPITRSIFPKDDDILLNYLDEDGQSIEPT 831

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LN++ ++PM PWY+GFKG+I
Sbjct: 832 WYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNNEPVEPMDPWYRGFKGSI 891

Query: 363 DKS 365
            K+
Sbjct: 892 QKT 894


>Q0DYE1_ORYSJ (tr|Q0DYE1) DNA topoisomerase 2 (Fragment) OS=Oryza sativa subsp.
           japonica GN=Os02g0699700 PE=2 SV=1
          Length = 956

 Score =  429 bits (1102), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 203/363 (55%), Positives = 267/363 (73%), Gaps = 3/363 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ-KLS 64
           YG +M M DQD+DGSHIKGLLINF +   PSL++IP FL E ITPII+A +    +  L 
Sbjct: 529 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKRDKKIVLP 588

Query: 65  FYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
           FYS PEYE+W ++ G   S W IKYYKGLG+ T  EG+++FQ++   +K FVW+ND+D +
Sbjct: 589 FYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKNDQDDN 648

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I +AFSK +  +R+  +  F+S  + D     I Y DF+ KE I +SMA + R IPS++
Sbjct: 649 DIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRSIPSMV 708

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FKR L  EI+V +  GYV+EHSAYHH E SLA+T+  MA+D+VGS 
Sbjct: 709 DGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQDFVGSN 768

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL  NGQFGT  QGGKD AS RYI+T L+PI+R +FP+ D+ LL YL+EDG S+EP 
Sbjct: 769 NINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQSIEPT 828

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LND+ ++PM PWY+GFKG+I
Sbjct: 829 WYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRGFKGSI 888

Query: 363 DKS 365
            K+
Sbjct: 889 QKT 891


>D8SXJ0_SELML (tr|D8SXJ0) DNA topoisomerase 2 OS=Selaginella moellendorffii
           GN=SELMODRAFT_127267 PE=3 SV=1
          Length = 1151

 Score =  429 bits (1102), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/366 (54%), Positives = 265/366 (72%), Gaps = 3/366 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF +   PSLL++P FL E ITPI++A H NG +
Sbjct: 509 KSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFITPIVKATHKNG-K 567

Query: 62  KLSFYSYPEYEKWWKNW--GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            LSFY+ PEYE W ++       W IKYYKGLG+ T +EGKE+F+++   +K F W NDE
Sbjct: 568 VLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDE 627

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D+I +AFSK KT  R+  +  ++   + D T   I Y DF+ KE IL+S+A + R +P
Sbjct: 628 DGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVP 687

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+ AFKR   ++ +V +  GYV+EHSAYHH E SLA+T++ MA+++V
Sbjct: 688 SMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFV 747

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NIN+L   GQFGT  QGGKDHAS RYIYT L P++R +FP+ D+ LL +L EDG S+
Sbjct: 748 GSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLREDGQSI 807

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP WY PI+P+VLVNG  GI TGW+  +P YNP+DI+ N+K  L D++L+PM PWYKGFK
Sbjct: 808 EPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKGFK 867

Query: 360 GTIDKS 365
           GTI KS
Sbjct: 868 GTIVKS 873


>R0G2R4_9BRAS (tr|R0G2R4) Uncharacterized protein OS=Capsella rubella
           GN=CARUB_v10012826mg PE=4 SV=1
          Length = 1284

 Score =  428 bits (1100), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/367 (54%), Positives = 264/367 (71%), Gaps = 2/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A +    
Sbjct: 520 VNSLRYGHMMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATNKKTK 579

Query: 61  QKLSFYSYPEYEKWWKNW-GNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + LSFYS PEYE W ++  GN+  W IKYYKGLG+   +EGKE+F N+ + +K FVW ++
Sbjct: 580 RVLSFYSMPEYEDWKESLRGNATGWEIKYYKGLGTSDAKEGKEYFSNLSLHKKDFVWEDE 639

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D +AI +AFSK K   R+  +  +    + D  +  I Y DF+ KE IL+SMA ++R I
Sbjct: 640 QDGEAIELAFSKKKIEARKNWLSNYVPGTHLDQKEPKITYSDFVNKELILFSMADLQRSI 699

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFK+ L  E++V +  GYVAEHSAYHH E SL +T++ MA+DY
Sbjct: 700 PSMVDGLKPGQRKILFSAFKKNLVKEMKVAQFSGYVAEHSAYHHGEQSLGSTIIGMAQDY 759

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           +GS NINLL   GQFGT   GGKD AS RYI+T L+P +R L+P+ D+ LL YLNEDG  
Sbjct: 760 LGSNNINLLKPKGQFGTRASGGKDAASTRYIFTVLSPATRVLYPKDDDVLLDYLNEDGQK 819

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP VLVNG  GI TGW+  IP YNP++I+ANI+R +N + + PM PWY+GF
Sbjct: 820 IEPTWYMPIIPTVLVNGSEGIGTGWSTFIPNYNPREIVANIRRLINGESVVPMDPWYRGF 879

Query: 359 KGTIDKS 365
           KGTI+KS
Sbjct: 880 KGTIEKS 886


>D8RNR7_SELML (tr|D8RNR7) DNA topoisomerase 2 OS=Selaginella moellendorffii
           GN=SELMODRAFT_98330 PE=3 SV=1
          Length = 1151

 Score =  427 bits (1099), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/366 (54%), Positives = 264/366 (72%), Gaps = 3/366 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF +   PSLL++P FL E ITPI++A H NG +
Sbjct: 509 KSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFITPIVKATHKNG-K 567

Query: 62  KLSFYSYPEYEKWWKNW--GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            LSFY+ PEYE W ++       W IKYYKGLG+ T +EGKE+F+++   +K F W NDE
Sbjct: 568 VLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDE 627

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D+I +AFSK KT  R+  +  ++   + D T   I Y DF+ KE IL+S+A + R +P
Sbjct: 628 DGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVP 687

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+ AFKR   ++ +V +  GYV+EHSAYHH E SLA+T++ MA+++V
Sbjct: 688 SMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFV 747

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NIN+L   GQFGT  QGGKDHAS RYIYT L P++R +FP+ D+ LL +L EDG S+
Sbjct: 748 GSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLREDGQSI 807

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP WY PI+P+VLVNG  GI TGW+  +P YNP+DI+ N+K  L D+ L+PM PWYKGFK
Sbjct: 808 EPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEPLEPMDPWYKGFK 867

Query: 360 GTIDKS 365
           GTI KS
Sbjct: 868 GTIVKS 873


>M0SVF6_MUSAM (tr|M0SVF6) DNA topoisomerase 2 OS=Musa acuminata subsp.
           malaccensis PE=3 SV=1
          Length = 1462

 Score =  427 bits (1099), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 203/366 (55%), Positives = 266/366 (72%), Gaps = 7/366 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P F+ E ITP+++    N    LSF
Sbjct: 529 YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFMVEFITPLLKVSLDNDTV-LSF 587

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           YS PEYE W ++ G +   W IKYYKGLG+   EEGK++F+ ++  +K FVW +++D DA
Sbjct: 588 YSMPEYEAWKESLGGNANGWSIKYYKGLGTSKSEEGKDYFKAIDKHKKDFVWVDEQDGDA 647

Query: 124 INIAFSKSKTRERRGLMLKFKS----SDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           I +AFSK K   R+  + +F++     +Y D  +  I Y DF+ KE IL+S A ++R IP
Sbjct: 648 IELAFSKKKIEARKNWLRQFEARCMPENYLDQREKLIKYSDFINKELILFSRADLQRSIP 707

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+ AFKR    + +V + +GYV+E SAYHH E SLATT++ MA+D+V
Sbjct: 708 SMVDGLKPGQRKILFCAFKRNFVKQAKVAQFVGYVSEKSAYHHGEQSLATTIIGMAQDFV 767

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL   GQFGT  QGGKDHAS RYI+T L+PI+RFLFP+ D+ LL YLNEDG S+
Sbjct: 768 GSNNINLLQPEGQFGTRHQGGKDHASARYIFTCLSPITRFLFPKDDDILLDYLNEDGQSI 827

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP WY+PIIP+VL NG  GI TGW+  IP YNPKDI+AN++R LN++ +QPM PWY+GF 
Sbjct: 828 EPTWYMPIIPMVLANGSEGIGTGWSSYIPNYNPKDIVANVRRLLNNEPMQPMDPWYRGFT 887

Query: 360 GTIDKS 365
           G I+KS
Sbjct: 888 GRIEKS 893


>M8BEA6_AEGTA (tr|M8BEA6) Uncharacterized protein OS=Aegilops tauschii
           GN=F775_52511 PE=4 SV=1
          Length = 1498

 Score =  427 bits (1098), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/363 (55%), Positives = 264/363 (72%), Gaps = 5/363 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A     ++   F
Sbjct: 536 YGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGKSVK--PF 593

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND-EDLD 122
           YS P+YE W ++ G S   W IKYYKGLG+ T EEG+++F+++ + +K FVW +D ED +
Sbjct: 594 YSMPDYEAWKEDLGASASSWTIKYYKGLGTSTAEEGRDYFEHIALHKKDFVWADDKEDGE 653

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           AI +AFSK K  ER+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++
Sbjct: 654 AIELAFSKKKISERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMV 713

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FK+ L  E +V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS 
Sbjct: 714 DGFKPGQRKILFCSFKKNLVKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSN 773

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFGT   GGKD AS RYI+T L P++R +FP+ D+ LL YLNEDG S+EP 
Sbjct: 774 NINLLEPRGQFGTRNAGGKDAASARYIFTRLQPVTRLIFPKDDDVLLNYLNEDGQSIEPS 833

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PIIP+VLVNG  GI TGW+  +P YNPKDIIAN+KR LN + + PMVPWY+GFKG++
Sbjct: 834 WYMPIIPMVLVNGSEGIGTGWSTYVPNYNPKDIIANLKRLLNGETIVPMVPWYRGFKGSL 893

Query: 363 DKS 365
            ++
Sbjct: 894 KET 896


>D8TGD2_SELML (tr|D8TGD2) DNA topoisomerase 2 (Fragment) OS=Selaginella
           moellendorffii GN=SELMODRAFT_138946 PE=3 SV=1
          Length = 980

 Score =  427 bits (1098), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/366 (54%), Positives = 264/366 (72%), Gaps = 3/366 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF +   PSLL++P FL E ITPI++A H NG +
Sbjct: 338 KSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFITPIVKATHKNG-K 396

Query: 62  KLSFYSYPEYEKWWKNW--GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            LSFY+ PEYE W ++       W IKYYKGLG+ T +EGKE+F+++   +K F W NDE
Sbjct: 397 VLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDE 456

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D+I +AFSK KT  R+  +  ++   + D T   I Y DF+ KE IL+S+A + R +P
Sbjct: 457 DGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVP 516

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+ AFKR   ++ +V +  GYV+EHSAYHH E SLA+T++ MA+++V
Sbjct: 517 SMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFV 576

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NIN+L   GQFGT  QGGKDHAS RYIYT L P++R +FP+ D+ LL +L EDG S+
Sbjct: 577 GSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLREDGQSI 636

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP WY PI+P+VLVNG  GI TGW+  +P YNP+DI+ N+K  L D+ L+PM PWYKGFK
Sbjct: 637 EPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEPLEPMDPWYKGFK 696

Query: 360 GTIDKS 365
           GTI KS
Sbjct: 697 GTIVKS 702


>M8AFG0_TRIUA (tr|M8AFG0) DNA topoisomerase 2 OS=Triticum urartu GN=TRIUR3_20318
           PE=4 SV=1
          Length = 1449

 Score =  427 bits (1098), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/360 (55%), Positives = 264/360 (73%), Gaps = 5/360 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A     ++   F
Sbjct: 506 YGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGKAVK--PF 563

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE-DLD 122
           YS P+YE W ++ G S   W IKYYKGLG+ T EEG+++F ++++ +K FVW NDE D +
Sbjct: 564 YSMPDYEAWKEDLGASASSWTIKYYKGLGTSTAEEGRDYFDHIDLHKKDFVWANDEKDNE 623

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           AI +AFSK K  ER+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++
Sbjct: 624 AIELAFSKKKIAERKEWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMV 683

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FK+ L  E +V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS 
Sbjct: 684 DGFKPGQRKILFCSFKKNLTKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSN 743

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFGT   GGKD AS RYI+T+L+PI+R +FP+ D+ LL YLNEDG S+EP 
Sbjct: 744 NINLLEPRGQFGTRNSGGKDAASARYIFTKLHPITRLIFPKDDDVLLNYLNEDGQSIEPS 803

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PIIP+VLVNG  GI TGW+  +P YNP+DIIAN+KR LN + + PM+PWY+GFKG++
Sbjct: 804 WYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNGETIVPMIPWYRGFKGSL 863


>N1QSK5_AEGTA (tr|N1QSK5) DNA topoisomerase 2 OS=Aegilops tauschii GN=F775_01510
           PE=4 SV=1
          Length = 1471

 Score =  427 bits (1097), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 201/363 (55%), Positives = 265/363 (73%), Gaps = 5/363 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A     ++  SF
Sbjct: 460 YGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGKAVK--SF 517

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND-EDLD 122
           YS P+YE W ++ G S   W IKYYKGLG+ T +EG+++F+++   +K FVW +D ED +
Sbjct: 518 YSMPDYEAWKESLGGSASSWTIKYYKGLGTSTAQEGRDYFEDITHHKKDFVWADDKEDGE 577

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           AI +AFSK K  ER+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++
Sbjct: 578 AIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMV 637

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FK+ L  E +V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS 
Sbjct: 638 DGFKPGQRKILFCSFKKNLVKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSN 697

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFGT   GGKD AS RYI+T L PI+R +FP+ D+ LL YLNEDG S+EP 
Sbjct: 698 NINLLEPRGQFGTRNAGGKDAASARYIFTRLQPITRLIFPKDDDVLLNYLNEDGQSIEPS 757

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PIIP+VLVNG  GI TGW+  +P YNP+DIIAN+KR LN++ + PMVPWY+GFKG++
Sbjct: 758 WYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNNETIVPMVPWYRGFKGSL 817

Query: 363 DKS 365
            ++
Sbjct: 818 KET 820


>M7Z036_TRIUA (tr|M7Z036) DNA topoisomerase 2 OS=Triticum urartu GN=TRIUR3_12968
           PE=4 SV=1
          Length = 1512

 Score =  426 bits (1095), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 200/363 (55%), Positives = 265/363 (73%), Gaps = 5/363 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A     ++  +F
Sbjct: 528 YGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGKAVK--AF 585

Query: 66  YSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND-EDLD 122
           YS P+YE W ++ G   S W IKYYKGLG+ T +EG+++F+++   +K FVW +D ED +
Sbjct: 586 YSMPDYEAWKESLGGNASSWTIKYYKGLGTSTAQEGRDYFEDITHHKKDFVWADDKEDGE 645

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           AI +AFSK K  ER+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++
Sbjct: 646 AIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMV 705

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FK+ L  E +V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS 
Sbjct: 706 DGFKPGQRKILFCSFKKNLVKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSN 765

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFGT   GGKD AS RYI+T L PI+R +FP+ D+ LL YLNEDG S+EP 
Sbjct: 766 NINLLEPRGQFGTRNAGGKDAASARYIFTRLQPITRLIFPKDDDVLLNYLNEDGQSIEPS 825

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WY+PIIP+VLVNG  GI TGW+  +P YNP+DIIAN+KR LN++ + PMVPWY+GFKG++
Sbjct: 826 WYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNNETIVPMVPWYRGFKGSL 885

Query: 363 DKS 365
            ++
Sbjct: 886 KET 888


>C5Y0E7_SORBI (tr|C5Y0E7) DNA topoisomerase 2 OS=Sorghum bicolor GN=Sb04g030880
           PE=3 SV=1
          Length = 1452

 Score =  426 bits (1094), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 196/363 (53%), Positives = 266/363 (73%), Gaps = 4/363 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++  FL E +TPII+A    G   +SF
Sbjct: 520 YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVESFLVEFVTPIIKA--TRGKTTISF 577

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ PEYE+W  N G S   W IKYYKGLG+ T +EG+E+F+++   +K FVW +D+D + 
Sbjct: 578 YTMPEYEEWRTNLGASASSWTIKYYKGLGTSTAKEGREYFKDITDHKKDFVWEDDQDGNH 637

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I +AFSK +  +R+  +  F+   Y D  +  + Y DF+ KE IL+SMA ++R IPS++D
Sbjct: 638 IELAFSKKRIADRKLWLTNFQPGTYIDQQEKRVRYSDFINKELILFSMADLQRSIPSMVD 697

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+ +FKR    E +V +  GYV+EHSAYHH E SLA+T++ MA+++VGS N
Sbjct: 698 GLKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNN 757

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           INL+   GQFGT  QGGKD ASPRYI+T+L+ I+R +FP+ D+ LL YLNEDG S+EP W
Sbjct: 758 INLMFPGGQFGTRAQGGKDAASPRYIFTKLSHITRSIFPKDDDILLNYLNEDGQSIEPTW 817

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LN++   PM PWY+GFKG+I+
Sbjct: 818 YMPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNEESTVPMHPWYRGFKGSIE 877

Query: 364 KSI 366
           K++
Sbjct: 878 KTV 880


>B9HNR6_POPTR (tr|B9HNR6) DNA topoisomerase 2 OS=Populus trichocarpa
           GN=POPTRDRAFT_557797 PE=3 SV=1
          Length = 1482

 Score =  426 bits (1094), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 209/366 (57%), Positives = 271/366 (74%), Gaps = 3/366 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A H NG 
Sbjct: 520 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT 579

Query: 61  QKLSFYSYPEYEKWWKNW-GN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
             LSFYS PEYE W ++  GN S W IKYYKGLG+ T +EGK++F+N+   +K F+W ++
Sbjct: 580 V-LSFYSMPEYESWKESLSGNASGWSIKYYKGLGTSTSKEGKDYFKNLHKHKKDFLWMDE 638

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
            D DAI +AFSK K   R+  + + +   + D+    I Y DF+ KE IL+SMA ++R I
Sbjct: 639 LDGDAIELAFSKKKIEARKNWLRQHEPGTHLDHNQKIIKYSDFINKELILFSMADLQRSI 698

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FKR    E +V +  GYV+EHSAYHH E SLA T++ MA+D+
Sbjct: 699 PSMVDGLKPGQRKILFCSFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDF 758

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL  NGQFGT   GGKDHAS RYIYT+L+PI+RFLFP+ D+ LL YL+EDG +
Sbjct: 759 VGSNNINLLQPNGQFGTRSVGGKDHASARYIYTQLSPITRFLFPKDDDGLLDYLDEDGQT 818

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP VLVNG  GI TGW+  IP YNP+D++ANI+R LN + ++PM PWY+GF
Sbjct: 819 IEPTWYMPIIPTVLVNGCEGIGTGWSTFIPNYNPRDVVANIRRLLNGEMMEPMNPWYRGF 878

Query: 359 KGTIDK 364
           KGTI+K
Sbjct: 879 KGTIEK 884


>C1E5N4_MICSR (tr|C1E5N4) DNA topoisomerase 2 OS=Micromonas sp. (strain RCC299 /
           NOUM17) GN=MICPUN_58377 PE=3 SV=1
          Length = 1459

 Score =  423 bits (1087), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 199/369 (53%), Positives = 267/369 (72%), Gaps = 6/369 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPII+A    G Q
Sbjct: 548 KSLRYGHIMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLVEFITPIIKA--TKGKQ 605

Query: 62  KLSFYSYPEYEKWWKNWGNSD----WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
              FY+ PEY+ W ++   +     W IKYYKGLG+ T +E KE+F  ++  +K F W  
Sbjct: 606 SKVFYTLPEYDNWKEHAEETGTGRGWNIKYYKGLGTSTAKEAKEYFAALDHHKKTFAWTT 665

Query: 118 DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRC 177
           D D + I++AFSK +  +R+  +  ++   Y D T   + Y DF+ KE IL+S A + R 
Sbjct: 666 DGDGNLIDMAFSKKRVEDRKAWLNAYEPGTYLDMTGDDVRYDDFINKELILFSRADLMRS 725

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS++DG KPSQRK+L+  FKR+L ++I+V +L GYV+EHSAYHH E+SLA+T++ +A+D
Sbjct: 726 IPSVVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLASTIVGLAQD 785

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           +VGS N+NLL+ +GQFGT +QGGKDHASPRYI+T L PI R +FPE D+ LL YL+EDG 
Sbjct: 786 FVGSNNVNLLVPSGQFGTRLQGGKDHASPRYIFTRLAPICRVIFPECDDALLDYLDEDGQ 845

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
            +EPE YLPI+PLVLVNG  GI TGW+ SIP +NP+DI+ANI+R L+D+  + M PWY+ 
Sbjct: 846 VIEPEHYLPILPLVLVNGADGIGTGWSTSIPNFNPRDIVANIRRILDDECTERMHPWYRN 905

Query: 358 FKGTIDKSI 366
           FKGTI++ I
Sbjct: 906 FKGTIEEEI 914


>E1Z4H4_CHLVA (tr|E1Z4H4) DNA topoisomerase 2 OS=Chlorella variabilis
           GN=CHLNCDRAFT_137783 PE=3 SV=1
          Length = 1566

 Score =  422 bits (1086), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 189/363 (52%), Positives = 264/363 (72%), Gaps = 2/363 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL++N+F+   PSLL++P FL E ITPII+A    G +
Sbjct: 521 KSLRYGHLMIMTDQDHDGSHIKGLIMNYFHHFYPSLLKLPGFLVEFITPIIKA--TKGKE 578

Query: 62  KLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            +SFY+ PEYE+W +      W IKY+KGLG+ T +E K++F N++  RK FVW  D D 
Sbjct: 579 TISFYTMPEYEEWSETHNTRGWTIKYFKGLGTSTADEAKQYFANIQSHRKEFVWDGDADG 638

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
            A+ +AFSK K  +R+  +  F    + D+T  +I Y  F+ KE IL+S A + R IP++
Sbjct: 639 QALEMAFSKKKVEDRKQWLQAFSPGTFLDHTADTISYSQFVHKELILFSRADLERSIPNM 698

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KP QRKI++  FKR L T+++V +L GYV+EHSAYHH E+SL+ T++ +A+D+VGS
Sbjct: 699 VDGLKPGQRKIMFACFKRNLKTDVKVSQLSGYVSEHSAYHHGEASLSGTIVGLAQDFVGS 758

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+N L+  GQFGT +QGGKD ASPRYI+T L P++R LF E D++LL YLNE+G S+EP
Sbjct: 759 NNVNYLVPQGQFGTRLQGGKDAASPRYIFTRLAPLTRHLFNEHDDRLLAYLNEEGQSIEP 818

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P++P VLVNG  GI TGW+ SIP +NP+DI+AN++  L+ ++   M PWY+GFKGT
Sbjct: 819 EWYMPVVPTVLVNGAEGIGTGWSTSIPNFNPRDIVANLRLMLDGEQPVAMKPWYRGFKGT 878

Query: 362 IDK 364
           I++
Sbjct: 879 IEE 881


>M0VXE2_HORVD (tr|M0VXE2) DNA topoisomerase 2 OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 881

 Score =  422 bits (1084), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 202/357 (56%), Positives = 258/357 (72%), Gaps = 5/357 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A     ++   F
Sbjct: 526 YGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGKTVE--PF 583

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND-EDLD 122
           YS P+YE W ++ G S   W IKYYKGLG+ T EEG+++F+ +   +K FVW +D ED D
Sbjct: 584 YSMPDYEAWKESLGTSASSWTIKYYKGLGTSTAEEGRDYFEQITRHKKDFVWADDKEDGD 643

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           AI +AFSK K  ER+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++
Sbjct: 644 AIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMV 703

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FK+ L  E +V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS 
Sbjct: 704 DGFKPGQRKILFCSFKKNLIKESKVAQFIGYVSEHSAYHHGEQSLASTIVGMAQDFVGSN 763

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFGT   GGKD AS RYI+T LNPI+R +FP+ D+ LL YLNEDG S+EP 
Sbjct: 764 NINLLEPRGQFGTRNAGGKDAASARYIFTRLNPITRLIFPKDDDVLLNYLNEDGQSIEPT 823

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           WY+PIIP+VLVNG  GI TGW+  +P YNP+DIIAN+KR LN + + PMVPWY+GFK
Sbjct: 824 WYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNGEAIVPMVPWYRGFK 880


>B3H4G2_ARATH (tr|B3H4G2) DNA topoisomerase 2 OS=Arabidopsis thaliana GN=TOPII
           PE=3 SV=1
          Length = 1438

 Score =  421 bits (1083), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 201/367 (54%), Positives = 269/367 (73%), Gaps = 2/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG++M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A      
Sbjct: 525 VNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKATRKGTK 584

Query: 61  QKLSFYSYPEYEKWWKNW-GNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + LSFYS PEYE+W ++  GN+  W IKYYKGLG+ T EEGKE+F N+ + +K FVW ++
Sbjct: 585 KVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDE 644

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D +AI +AFSK K   R+  +  +   ++ D     + Y DF+ KE IL+SMA ++R I
Sbjct: 645 QDGEAIELAFSKKKIEARKNWLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADLQRSI 704

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFK+    E++V +L+GYV+  SAYHH E SLA+ ++ MA+DY
Sbjct: 705 PSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLSAYHHGEQSLASAIIGMAQDY 764

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL+ NGQFGT   GGKD AS RYI+T+L+P++R LFP+ D+ LL YLNEDG  
Sbjct: 765 VGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQR 824

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP VLVNG  GI TGW+  IP YNP++I+AN++R LN + + PM PWY+GF
Sbjct: 825 IEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGF 884

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 885 KGTIEKT 891


>D7L459_ARALL (tr|D7L459) DNA topoisomerase 2 OS=Arabidopsis lyrata subsp. lyrata
           GN=ARALYDRAFT_898932 PE=3 SV=1
          Length = 1432

 Score =  421 bits (1083), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 200/367 (54%), Positives = 267/367 (72%), Gaps = 2/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPI++A +    
Sbjct: 523 VSSLRYGHMMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKAKNKAKK 582

Query: 61  QKLSFYSYPEYEKWWKNW-GNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           + LSFYS PEYE W ++  GN+  W IKYYKGLG+ T EE KE+F+N+ + +K FVW ++
Sbjct: 583 KVLSFYSMPEYEDWKESMKGNATGWEIKYYKGLGTSTTEEAKEYFKNLGLHKKDFVWEDE 642

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
           +D +AI +AFSK K   R+  +  +    + D  +  + Y DF+ KE IL+SMA ++R I
Sbjct: 643 QDGEAIELAFSKKKIEARKNWLSNYVPGTHLDQREPKVTYSDFVNKELILFSMADLQRSI 702

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ AFK+ +  E++V +L+GYV+  SAYHH E SLA+ ++ MA+DY
Sbjct: 703 PSMVDGLKPGQRKILFTAFKKIVVKEMKVAQLVGYVSSMSAYHHGEQSLASAIIGMAQDY 762

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL  NGQFGT   GGKD AS RYI+T L+P++R LFP+ D+ LL YLNEDG S
Sbjct: 763 VGSNNINLLQPNGQFGTRNSGGKDAASARYIFTILSPVTRILFPKDDHILLDYLNEDGQS 822

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIP VLVNG  GI TGW+  IP YNP++I+AN++  LN + + PM PWY+GF
Sbjct: 823 IEPTWYMPIIPTVLVNGSEGIGTGWSTFIPNYNPREIVANVRCRLNGESMVPMDPWYRGF 882

Query: 359 KGTIDKS 365
           KGTI+K+
Sbjct: 883 KGTIEKT 889


>A9SRT5_PHYPA (tr|A9SRT5) DNA topoisomerase 2 (Fragment) OS=Physcomitrella patens
           subsp. patens GN=PHYPADRAFT_134247 PE=3 SV=1
          Length = 1172

 Score =  421 bits (1083), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 202/366 (55%), Positives = 262/366 (71%), Gaps = 4/366 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPI++A   N  +
Sbjct: 522 KSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKA--TNKQK 579

Query: 62  KLSFYSYPEYEKWWK--NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            LSFY+ PEYE W +  N     W IKYYKGLG+ T +EGKE+F+ +   +K F W ++ 
Sbjct: 580 TLSFYTMPEYEAWKESLNGETKGWTIKYYKGLGTSTSKEGKEYFRELVKHKKDFKWESEM 639

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D DAI +AFSK K   R+  +  ++   + D T   I Y+DF+ KE IL+SMA + R IP
Sbjct: 640 DGDAIEMAFSKKKIEARKTWLRHYEPGTFLDMTAEKINYRDFVNKELILFSMADLARSIP 699

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+  FKR   T+ +V +  GYV+EHSAYHH E+SLA+T++ MA+++V
Sbjct: 700 SMVDGLKPGQRKILFCCFKRNFVTQAKVAQFSGYVSEHSAYHHGEASLASTIIGMAQNFV 759

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL   GQFGT  QGGK+HASPRYI+T L PI+R LFP+ D+ LL YL EDG S+
Sbjct: 760 GSNNINLLSPEGQFGTREQGGKNHASPRYIFTCLAPITRALFPQADDVLLDYLKEDGQSI 819

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP WY PIIPLVLVNG  GI TGW+  +P YNP++I+AN++R L   +++PM PWYKGFK
Sbjct: 820 EPTWYCPIIPLVLVNGSEGIGTGWSSFVPNYNPREIVANLRRLLAGQEMEPMHPWYKGFK 879

Query: 360 GTIDKS 365
           G+I+ S
Sbjct: 880 GSIECS 885


>B9GFC4_POPTR (tr|B9GFC4) DNA topoisomerase 2 OS=Populus trichocarpa
           GN=POPTRDRAFT_706393 PE=3 SV=1
          Length = 1468

 Score =  421 bits (1081), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 209/379 (55%), Positives = 274/379 (72%), Gaps = 16/379 (4%)

Query: 1   MESFIYGRVMFMADQ-------------DYDGSHIKGLLINFFYMLSPSLLRIPYFLSEL 47
           ++S  YG +M M DQ             D+DGSHIKGLLINF +   PSLL++P FL E 
Sbjct: 504 VKSLRYGHLMIMTDQAKERFANFLCFKQDHDGSHIKGLLINFLHSFWPSLLKVPSFLVEF 563

Query: 48  ITPIIRAFHCNGIQKLSFYSYPEYEKWWKNW-GN-SDWRIKYYKGLGSFTHEEGKEFFQN 105
           ITPI++A H NG   LSFYS PEYE W  +  GN S W IKYYKGLG+ T +EGK +FQ+
Sbjct: 564 ITPIVKATHRNGTV-LSFYSMPEYESWKGSLAGNASGWSIKYYKGLGTSTSKEGKAYFQS 622

Query: 106 VEIQRKYFVWRNDEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKE 165
           ++  +K F+W +++D DAI +AFSK K   R+  + +++   + D     I Y DF+ KE
Sbjct: 623 LDKHKKDFIWMDEQDGDAIELAFSKKKIEARKNWLRQYEPGTHLDQNQKLIKYSDFINKE 682

Query: 166 FILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDES 225
            IL+SMA ++R IPS++DG KP QRKIL+ +FKR    E ++ +  GYV+EHSAYHH E 
Sbjct: 683 LILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAKISQFSGYVSEHSAYHHGEQ 742

Query: 226 SLATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEID 285
           SLA+T++ MA+D+VGS NINLL+ NGQFGT   GGKDHAS RYIYT+L+PI+RFLFP+ D
Sbjct: 743 SLASTIIGMAQDFVGSNNINLLLPNGQFGTRSVGGKDHASARYIYTQLSPITRFLFPKDD 802

Query: 286 NKLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLND 345
           + LL YL+EDG ++EP WY+PIIP+VLVNG  GI TGW+  IP YNP+DI+ANI+R LN 
Sbjct: 803 DGLLDYLDEDGQTIEPNWYMPIIPMVLVNGCEGIGTGWSTFIPNYNPRDIVANIRRLLNG 862

Query: 346 DKLQPMVPWYKGFKGTIDK 364
           + ++PM PWY+GFKGTI+K
Sbjct: 863 EMMEPMNPWYRGFKGTIEK 881


>M0VXE3_HORVD (tr|M0VXE3) Uncharacterized protein OS=Hordeum vulgare var.
           distichum PE=4 SV=1
          Length = 546

 Score =  421 bits (1081), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 202/357 (56%), Positives = 258/357 (72%), Gaps = 5/357 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL++P FL E ITPII+A     ++   F
Sbjct: 191 YGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGKTVE--PF 248

Query: 66  YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND-EDLD 122
           YS P+YE W ++ G S   W IKYYKGLG+ T EEG+++F+ +   +K FVW +D ED D
Sbjct: 249 YSMPDYEAWKESLGTSASSWTIKYYKGLGTSTAEEGRDYFEQITRHKKDFVWADDKEDGD 308

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           AI +AFSK K  ER+  +  ++     D  +  I Y DF+ KE IL+SMA + R IPS++
Sbjct: 309 AIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLERSIPSMV 368

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+ +FK+ L  E +V + IGYV+EHSAYHH E SLA+T++ MA+D+VGS 
Sbjct: 369 DGFKPGQRKILFCSFKKNLIKESKVAQFIGYVSEHSAYHHGEQSLASTIVGMAQDFVGSN 428

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFGT   GGKD AS RYI+T LNPI+R +FP+ D+ LL YLNEDG S+EP 
Sbjct: 429 NINLLEPRGQFGTRNAGGKDAASARYIFTRLNPITRLIFPKDDDVLLNYLNEDGQSIEPT 488

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           WY+PIIP+VLVNG  GI TGW+  +P YNP+DIIAN+KR LN + + PMVPWY+GFK
Sbjct: 489 WYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNGEAIVPMVPWYRGFK 545


>C1MN24_MICPC (tr|C1MN24) DNA topoisomerase 2 OS=Micromonas pusilla (strain
           CCMP1545) GN=MICPUCDRAFT_46870 PE=3 SV=1
          Length = 1473

 Score =  417 bits (1072), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 195/368 (52%), Positives = 266/368 (72%), Gaps = 5/368 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPII+A    G +
Sbjct: 549 KSLRYGHIMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLVEFITPIIKA--TKGKK 606

Query: 62  KLSFYSYPEYEKWWKNWGNSD---WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
              FY+ PEYE + ++ G++    W IKYYKGLG+ T +E KE+F  +   RK F W +D
Sbjct: 607 SEVFYTMPEYENFKESLGDAGTKGWSIKYYKGLGTSTSKEAKEYFAALAHHRKTFTWSDD 666

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
              D I++AFSK +  +R+  +  ++   + D T   + Y DF+ KE IL+S A + R I
Sbjct: 667 NSGDLIDMAFSKKRVDDRKQWLTAYEPGTFLDMTGDDVGYDDFVNKELILFSRADLMRSI 726

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KPSQRK+L+  FKR+L ++I+V +L GYV+EHSAYHH E+SLA+T++ +A+D+
Sbjct: 727 PSVVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLASTIVGLAQDF 786

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL+ +GQFGT +QGGKDHASPRYI+T L PI R +FPE D+ LL Y+NEDG  
Sbjct: 787 VGSNNVNLLVPSGQFGTRLQGGKDHASPRYIFTRLAPICRAIFPEADDALLDYINEDGQV 846

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP++YLPI+PLVLVNG  GI TGW+ SIP YNP+D+  NI+R LND++ + M PWY+ F
Sbjct: 847 IEPDYYLPILPLVLVNGADGIGTGWSTSIPNYNPRDLTDNIRRLLNDEEPERMHPWYRNF 906

Query: 359 KGTIDKSI 366
            G++ + I
Sbjct: 907 NGSLTEEI 914


>A9RWX5_PHYPA (tr|A9RWX5) DNA topoisomerase 2 (Fragment) OS=Physcomitrella patens
           subsp. patens GN=PHYPADRAFT_120620 PE=3 SV=1
          Length = 1238

 Score =  416 bits (1069), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 202/366 (55%), Positives = 258/366 (70%), Gaps = 4/366 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPI++A   N  +
Sbjct: 523 KSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKA--SNKQK 580

Query: 62  KLSFYSYPEYEKWWK--NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            LSFY+ PEYE W +  N     W IKYYKGLG+ T +EGKE+F+ +   +K F W ++ 
Sbjct: 581 MLSFYTMPEYEAWKESLNGETKGWTIKYYKGLGTSTSKEGKEYFRELSKHKKDFKWESEM 640

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D DAI +AFSK K   R+  +  ++   + D T   I Y DF+ KE IL+SMA + R IP
Sbjct: 641 DGDAIEMAFSKKKIEARKTWLRHYEPGTFLDMTADKIKYSDFVNKELILFSMADLARSIP 700

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+  FKR   T+ +V +  GYV+EHSAYHH E+SLA+T++ MA+++V
Sbjct: 701 SMVDGLKPGQRKILFCCFKRNFVTQAKVAQFSGYVSEHSAYHHGEASLASTIIGMAQNFV 760

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL   GQFGT  QGGK+HASPRYI+T L PI+R LFP+ D+ LL Y+ EDG S+
Sbjct: 761 GSNNINLLSPEGQFGTREQGGKNHASPRYIFTCLAPITRALFPQPDDVLLDYMKEDGQSI 820

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP WY PIIPLVLVNG  GI TGW+  +P YNP++I+ANI+R L   +L PM PWYK F 
Sbjct: 821 EPSWYCPIIPLVLVNGSEGIGTGWSSFVPNYNPREIVANIRRLLAGQELTPMHPWYKSFM 880

Query: 360 GTIDKS 365
           GTI+ S
Sbjct: 881 GTIECS 886


>D8U578_VOLCA (tr|D8U578) DNA topoisomerase 2 OS=Volvox carteri
           GN=VOLCADRAFT_94598 PE=3 SV=1
          Length = 1126

 Score =  416 bits (1069), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 200/362 (55%), Positives = 257/362 (70%), Gaps = 4/362 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG +M M DQD+DGSHIKGL++NF +   PSLL+IP F+ E ITPI++A    G + 
Sbjct: 511 SLRYGHLMIMTDQDHDGSHIKGLIMNFMHSFFPSLLKIPGFMLEFITPIVKARR--GRET 568

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
             FY+ PEYE W ++  N  S W IKYYKGLG+ T EE +E+F  + + RK FVW  DED
Sbjct: 569 KVFYTMPEYEAWKESLDNNTSGWDIKYYKGLGTSTKEEAQEYFSRLNLHRKEFVWTGDED 628

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            DAI +AFSK +  +R+  +  F    Y D +   I Y DF+ KE IL+S A + R IP+
Sbjct: 629 GDAIELAFSKKRVDDRKEWLSNFVPGTYLDQSAEKISYADFINKELILFSRADLDRSIPN 688

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRKI++  FKR L  +I+V +L  YVAEHSAYHH E SLA+T++ +A+D+VG
Sbjct: 689 VLDGLKPGQRKIMFACFKRNLKKDIKVAQLSAYVAEHSAYHHGEQSLASTIVNLAQDFVG 748

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL  +GQFGT +QGGKD AS RYIYT L  ++R LF E D+ LLKYLNE+G S+E
Sbjct: 749 SNNINLLHPSGQFGTRLQGGKDAASARYIYTRLEKLTRHLFNEHDDVLLKYLNEEGQSIE 808

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWYLPI+P VLVNG  GI TGW+  IP YNP+DIIAN++R LN ++  P+ PWY+GF G
Sbjct: 809 PEWYLPILPTVLVNGAEGIGTGWSTFIPNYNPRDIIANLRRLLNGEEQDPLHPWYRGFTG 868

Query: 361 TI 362
           TI
Sbjct: 869 TI 870


>A8JD08_CHLRE (tr|A8JD08) DNA topoisomerase 2 (Fragment) OS=Chlamydomonas
           reinhardtii GN=TOP2 PE=3 SV=1
          Length = 1167

 Score =  414 bits (1064), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 195/365 (53%), Positives = 258/365 (70%), Gaps = 4/365 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG +M M DQD+DGSHIKGL++NF +   PSLLRIP FL E ITPI++A    G   
Sbjct: 526 SLRYGHLMIMTDQDHDGSHIKGLIMNFLHSFFPSLLRIPGFLLEFITPIVKARR--GRDT 583

Query: 63  LSFYSYPEYEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
             FY+ PEYE W ++ GN+   W IKYYKGLG+ T EE +E+F  +++ RK FVW  DED
Sbjct: 584 KVFYTMPEYEAWKESLGNATTAWDIKYYKGLGTSTKEEAQEYFSRLDLHRKEFVWEGDED 643

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            D+I +AFSK +  +R+  +  F    + D +   I Y DF+ +E IL+S A + R IPS
Sbjct: 644 GDSIELAFSKKRVDDRKEWLSNFVPGTFLDQSADRISYSDFINRELILFSRADLDRSIPS 703

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRKILY  FKR L  +I+V +L  YVAEHSAYHH E SLA+T++ +A+D+VG
Sbjct: 704 MLDGLKPGQRKILYACFKRNLKKDIKVAQLSAYVAEHSAYHHGEGSLASTIVNLAQDFVG 763

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S N+NLL  +GQFGT +QGGKD AS RYIYT L  ++R LF E D++LL YLNE+G S+E
Sbjct: 764 SNNVNLLHPSGQFGTRLQGGKDAASARYIYTRLAALTRHLFNENDDQLLTYLNEEGQSIE 823

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWY+PI+P VL+NG  GI TGW+ +IP YNP+DI+AN++R L  +  + M PWY+GF G
Sbjct: 824 PEWYMPILPTVLINGADGIGTGWSTTIPNYNPRDIMANLRRLLEGEAQEAMHPWYRGFNG 883

Query: 361 TIDKS 365
            I ++
Sbjct: 884 NIAEA 888


>A4S645_OSTLU (tr|A4S645) DNA topoisomerase 2 OS=Ostreococcus lucimarinus (strain
           CCE9901) GN=OSTLU_41836 PE=3 SV=1
          Length = 1292

 Score =  414 bits (1064), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 196/366 (53%), Positives = 266/366 (72%), Gaps = 3/366 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG++M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPII+A    G Q
Sbjct: 523 KSLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLLEFITPIIKA--TKGKQ 580

Query: 62  KLSFYSYPEYEKWWK-NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
              FY+ PEYE W + N G S W IKYYKGLG+ T  E KE+F +++  RK FVW++D D
Sbjct: 581 SKVFYTMPEYEAWKEANDGTSGWSIKYYKGLGTSTANEAKEYFASLDHHRKSFVWQSDGD 640

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            D I+++FSK +  +R+  +  ++   + D T   I Y +F+ KE IL+S A + R IPS
Sbjct: 641 GDLIDMSFSKKRVVDRKAWLTAYEPGTFLDMTGEDIRYDEFINKELILFSRADLLRSIPS 700

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KPSQRK+L+  FKR+L ++I+V +L GYV+EHSAYHH E+SLA T++ +A+D+VG
Sbjct: 701 MVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLAMTIVNLAQDFVG 760

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+ +GQFGT +QGGKDHASPRYI+T L+ + R +FPE D+ LL YL+EDG  +E
Sbjct: 761 SNNINLLVPSGQFGTRLQGGKDHASPRYIFTRLHEVCRAMFPECDDALLNYLDEDGQRIE 820

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P++Y P++PLVLVNG  GI TGW+ SIP +NP+D+IANI+  L  +    M PWY+ FKG
Sbjct: 821 PDYYYPVLPLVLVNGAEGIGTGWSTSIPNFNPRDLIANIRLVLEGESPVQMHPWYRHFKG 880

Query: 361 TIDKSI 366
           +I + +
Sbjct: 881 SITEEL 886


>Q00XH2_OSTTA (tr|Q00XH2) DNA topoisomerase 2 OS=Ostreococcus tauri GN=Ot13g00110
           PE=3 SV=1
          Length = 1099

 Score =  413 bits (1061), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 195/366 (53%), Positives = 268/366 (73%), Gaps = 3/366 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG++M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPII+A    G Q
Sbjct: 547 KSLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLLEFITPIIKA--TKGKQ 604

Query: 62  KLSFYSYPEYEKWWK-NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
              FY+ PEYE W + N G++ W IKYYKGLG+ T  E KE+F +++  RK F+W +D D
Sbjct: 605 SKVFYTLPEYETWKEANQGSAGWSIKYYKGLGTSTANEAKEYFASLDHHRKNFIWESDGD 664

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            D I+++FSK +  +R+  +  ++   + D +  +I Y +F+ KE IL+S A + R IPS
Sbjct: 665 GDLIDMSFSKKRVEDRKAWLNAYEPGTFLDMSGEAIRYDEFINKELILFSRADLLRSIPS 724

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KPSQRK+L+  FKR+L ++I+V +L GYV+EHSAYHH E+SLA T++ +A+D+VG
Sbjct: 725 MVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLAMTIVNLAQDFVG 784

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+ +GQFGT +QGGKDHASPRYI+T L+ I R +FPE D+ LL YL+EDG  +E
Sbjct: 785 SNNINLLVPSGQFGTRLQGGKDHASPRYIFTRLHEICRAIFPECDDALLNYLDEDGQRIE 844

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P++Y P++PLVLVNG  GI TGW+ SIP +NP+DII+NIK  L  ++ + M PWY+ F G
Sbjct: 845 PDFYYPVLPLVLVNGAEGIGTGWSTSIPNFNPRDIISNIKLVLEGEEARQMHPWYRNFNG 904

Query: 361 TIDKSI 366
           +I + I
Sbjct: 905 SIVEEI 910


>M1V3P5_CYAME (tr|M1V3P5) DNA topoisomerase 2 OS=Cyanidioschyzon merolae strain
           10D GN=CYME_CMB013C PE=3 SV=1
          Length = 1576

 Score =  412 bits (1058), Expect = e-112,   Method: Composition-based stats.
 Identities = 186/368 (50%), Positives = 263/368 (71%), Gaps = 11/368 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNG--IQKL 63
           YG VM M DQD+DGSHIKGLL+NFF+   PSLLRIP FL E ITPI++A    G  ++++
Sbjct: 525 YGHVMIMTDQDHDGSHIKGLLVNFFHHFWPSLLRIPGFLLEFITPIVKATAKRGERLEEV 584

Query: 64  SFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
            F++ PEY++W ++  +   W IKYYKGLG+ T  E + +F N+   +  FVW+N  D +
Sbjct: 585 VFFTIPEYQQWRQSQSSLRGWTIKYYKGLGTSTAAEARTYFSNLSRHQIPFVWQNHADYE 644

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
           +I +AFSK K +ER+  +   K   Y D+   ++ Y +F+ KE +L+S+A   R IP LI
Sbjct: 645 SIELAFSKHKVQERKDWLAAHKLGTYFDHAADTLTYANFVHKELVLFSLADNARSIPCLI 704

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRK+L+  FKR+L+ EI+V +L GYV+EH+AYHH E+SL  T++ +A+++VGS 
Sbjct: 705 DGLKPSQRKVLFACFKRKLYQEIKVAQLAGYVSEHAAYHHGEASLMATIIGLAQNFVGSN 764

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           N+NLL+  GQFGT + GGKD ASPRYI+T L P++R LFPE D+ LL+YL EDG+S+EP+
Sbjct: 765 NLNLLVPAGQFGTRLSGGKDAASPRYIFTCLAPVARALFPEADDVLLEYLEEDGLSIEPK 824

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFL--------NDDKLQPMVPW 354
           WY P+IPLVLVNG  GI TGW+ +IPC+NP+D++  ++  L         D++   +VPW
Sbjct: 825 WYCPVIPLVLVNGAEGIGTGWSTNIPCHNPRDLVRILRSMLLESHGALDADNESATLVPW 884

Query: 355 YKGFKGTI 362
           Y+GF+G+I
Sbjct: 885 YRGFRGSI 892


>K8F0A4_9CHLO (tr|K8F0A4) DNA topoisomerase 2 OS=Bathycoccus prasinos
           GN=Bathy02g05900 PE=3 SV=1
          Length = 1444

 Score =  410 bits (1054), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 188/367 (51%), Positives = 265/367 (72%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD+DGSHIKGLLINF +   PSLL+IP FL E ITPII+A    G 
Sbjct: 549 IKTLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLLEFITPIIKA--TKGQ 606

Query: 61  QKLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q   FY+ PEYE W   N     W IKYYKGLG+ T +E KE+F  +E+ RK F W +D 
Sbjct: 607 QTRVFYTLPEYENWKLVNNDGKGWAIKYYKGLGTSTAKEAKEYFAAIELHRKTFCWESDG 666

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D I+++FSK +  +R+  +  ++   + D +  ++ Y +F+ KE IL+S+A + R IP
Sbjct: 667 DGDLIDMSFSKKRVEDRKRWLSAYEEGTFLDQSGETVRYDEFINKELILFSLADLMRSIP 726

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S IDG KPSQRK+++  FKR+L ++I+V +L GYV+EHSAYHH E+SLA+T++ +A+D+V
Sbjct: 727 SAIDGFKPSQRKVMFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLASTIVNLAQDFV 786

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           G+ NINLL+ +GQFGT +QGGKDHASPRYI+T L  ++R +FPE D+ LL Y +EDG  +
Sbjct: 787 GTNNINLLVPSGQFGTRLQGGKDHASPRYIFTRLAQLARVVFPECDDALLNYNDEDGQKI 846

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP +Y+P+IP VL+NG  GI TGW+ SIP YN +D+I+N++  LN+++   M+PWY+ FK
Sbjct: 847 EPTYYMPVIPTVLINGAEGIGTGWSTSIPNYNARDVISNVRAILNEEEPTQMMPWYRHFK 906

Query: 360 GTIDKSI 366
           G I + I
Sbjct: 907 GEITEEI 913


>G7J2H1_MEDTR (tr|G7J2H1) DNA topoisomerase 2 OS=Medicago truncatula
           GN=MTR_3g085840 PE=3 SV=1
          Length = 1345

 Score =  409 bits (1051), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 200/368 (54%), Positives = 258/368 (70%), Gaps = 32/368 (8%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M MADQD+DGSHIKGLLINF +   PSLL++P F+ E  TPIIR  H NG 
Sbjct: 490 VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFIVEFTTPIIRVSHSNGT 549

Query: 61  QKLSFYSYPEYEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
            KLSFYS  +YE W K  GN+   W+IKYYKGLG+ T +EG+E+FQ+++   K F+W   
Sbjct: 550 -KLSFYSMSDYEVWRKRIGNNANCWKIKYYKGLGTSTSQEGREYFQDLDKHMKEFIW--- 605

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
                                      S   D     I YK F+ +E IL+S A ++R I
Sbjct: 606 --------------------------PSTCHDLEAKLIRYKSFIDRELILFSRAELQRSI 639

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKIL+ +FK++L+ EI+V + IGYV+ HSAYHH E SLA T++ MA+D+
Sbjct: 640 PSMVDGLKPGQRKILFCSFKKKLYKEIKVSQFIGYVSLHSAYHHGEQSLANTIIGMAQDF 699

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VG  NINLL  NGQFGT   GGKDHASP+YIYTELN ++RFLF E D+KLLKYLNE+G S
Sbjct: 700 VGGNNINLLNPNGQFGTRNLGGKDHASPKYIYTELNIVTRFLFHEDDDKLLKYLNEEGKS 759

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           +EP WY+PIIPLVLVNG   I TGW+  IP YNP++IIAN++R LN++++ PM PWY+GF
Sbjct: 760 IEPNWYIPIIPLVLVNGSEEIGTGWSSYIPNYNPREIIANVRRLLNEEEMVPMDPWYRGF 819

Query: 359 KGTIDKSI 366
           +GTI+KS+
Sbjct: 820 RGTIEKSM 827


>Q0PWB2_PLEOS (tr|Q0PWB2) DNA topoisomerase 2 OS=Pleurotus ostreatus GN=TopII
           PE=2 SV=1
          Length = 1571

 Score =  404 bits (1037), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 188/363 (51%), Positives = 255/363 (70%), Gaps = 3/363 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YGR+M M DQD+DGSHIKGLLINF     PSLL++P FL E +TPI+R     G 
Sbjct: 605 VSSLRYGRLMIMTDQDHDGSHIKGLLINFLDHFYPSLLKVPEFLVEFVTPIVRV--TKGN 662

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+ +F++ PEYE W +   +S  W  KYYKGLG+ +  + +E+F  +      F    DE
Sbjct: 663 QRKNFFTIPEYETWLEETPDSKKWTAKYYKGLGTSSDADAREYFSQMGKHMIPFATMEDE 722

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           +   I++AFSK K  +R+    +FK   Y D+    I + DF+ KE IL+SMA   R IP
Sbjct: 723 ERALIDLAFSKKKADDRKEWQRQFKPGTYLDHNIDEIPFTDFINKELILFSMADNIRSIP 782

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S+ DG KP QRK+++G FKR+L  EI+V +L+GY++EH+AYHH E SL++T++ +A++YV
Sbjct: 783 SVADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEMSLSSTIVNLAQNYV 842

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL  NGQ+GT  QGGKDHASPRYIYTE+ P++R L    D+ LLK   +D + V
Sbjct: 843 GSNNINLLSPNGQYGTRDQGGKDHASPRYIYTEIAPLTRLLCRPSDDPLLKRQTDDNLLV 902

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPEWYLPIIP+VLVNG  GI TGW+ +IPCYNP DI+ANI+R +N +++ PM+PW++GFK
Sbjct: 903 EPEWYLPIIPMVLVNGAEGIGTGWSTTIPCYNPVDIVANIRRLMNGEEVVPMLPWWRGFK 962

Query: 360 GTI 362
           G +
Sbjct: 963 GEV 965


>F8QG51_SERL3 (tr|F8QG51) DNA topoisomerase 2 OS=Serpula lacrymans var. lacrymans
           (strain S7.3) GN=SERLA73DRAFT_172653 PE=3 SV=1
          Length = 1484

 Score =  403 bits (1035), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 187/363 (51%), Positives = 258/363 (71%), Gaps = 3/363 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YGR+M M DQD+DGSHIKGLLINF     PSLL+IP FL E +TPI+R     G Q+
Sbjct: 601 SLRYGRLMIMTDQDHDGSHIKGLLINFLDHFFPSLLKIPNFLVEFVTPIVRV--SKGKQR 658

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + F++ PEYE+W ++  ++  W  KY+KGLG+ +  + + +F N+      F    D D 
Sbjct: 659 IDFFTIPEYEQWVEDTPDAHKWDAKYFKGLGTSSDSDARLYFSNMAKHMIPFAATQDGDK 718

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I +AFSK K  ER+  + +FK+  Y D+    I Y DF+ +E IL+SMA   R IP+L
Sbjct: 719 ELIELAFSKKKADERKEWLRQFKAGTYLDHNIDEISYSDFINRELILFSMADNIRSIPAL 778

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
            DG KP QRK+++G FKR+L  EI+V +L+GY++E +AYHH E+SL  T++ +A+DYVGS
Sbjct: 779 ADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEVAAYHHGEASLTMTIVNLAQDYVGS 838

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQ+GT  QGGKDHAS RYI+TEL+P++R ++   D+ LL YL ED   +EP
Sbjct: 839 NNVNLLLPNGQYGTRDQGGKDHASARYIFTELSPLARTIYNPADDPLLTYLKEDNDWIEP 898

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+YLP+IPLVL+NG  GI TGW+ SIPCYNP+DI+ NI+R +  ++L PM+PW++GFKGT
Sbjct: 899 EYYLPVIPLVLINGAEGIGTGWSTSIPCYNPEDIVNNIRRMMAGEELVPMLPWWRGFKGT 958

Query: 362 IDK 364
           I K
Sbjct: 959 IKK 961


>F8PB32_SERL9 (tr|F8PB32) DNA topoisomerase 2 OS=Serpula lacrymans var. lacrymans
           (strain S7.9) GN=SERLADRAFT_453445 PE=3 SV=1
          Length = 1467

 Score =  402 bits (1034), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 187/363 (51%), Positives = 258/363 (71%), Gaps = 3/363 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YGR+M M DQD+DGSHIKGLLINF     PSLL+IP FL E +TPI+R     G Q+
Sbjct: 584 SLRYGRLMIMTDQDHDGSHIKGLLINFLDHFFPSLLKIPNFLVEFVTPIVRV--SKGKQR 641

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + F++ PEYE+W ++  ++  W  KY+KGLG+ +  + + +F N+      F    D D 
Sbjct: 642 IDFFTIPEYEQWVEDTPDAHKWDAKYFKGLGTSSDSDARLYFSNMAKHMIPFAATQDGDK 701

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I +AFSK K  ER+  + +FK+  Y D+    I Y DF+ +E IL+SMA   R IP+L
Sbjct: 702 ELIELAFSKKKADERKEWLRQFKAGTYLDHNIDEISYSDFINRELILFSMADNIRSIPAL 761

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
            DG KP QRK+++G FKR+L  EI+V +L+GY++E +AYHH E+SL  T++ +A+DYVGS
Sbjct: 762 ADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEVAAYHHGEASLTMTIVNLAQDYVGS 821

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQ+GT  QGGKDHAS RYI+TEL+P++R ++   D+ LL YL ED   +EP
Sbjct: 822 NNVNLLLPNGQYGTRDQGGKDHASARYIFTELSPLARTIYNPADDPLLTYLKEDNDWIEP 881

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+YLP+IPLVL+NG  GI TGW+ SIPCYNP+DI+ NI+R +  ++L PM+PW++GFKGT
Sbjct: 882 EYYLPVIPLVLINGAEGIGTGWSTSIPCYNPEDIVNNIRRMMAGEELVPMLPWWRGFKGT 941

Query: 362 IDK 364
           I K
Sbjct: 942 IKK 944


>J4ICG2_FIBRA (tr|J4ICG2) DNA topoisomerase 2 OS=Fibroporia radiculosa (strain
           TFFH 294) GN=FIBRA_08613 PE=3 SV=1
          Length = 1571

 Score =  402 bits (1032), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 183/361 (50%), Positives = 258/361 (71%), Gaps = 3/361 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG++M M DQD+DGSHIKGLLIN+F    PSLL++P+FL E +TPIIRA    G Q + F
Sbjct: 604 YGQLMIMTDQDHDGSHIKGLLINYFEHFYPSLLKVPHFLVEFVTPIIRA--TKGTQLIEF 661

Query: 66  YSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           Y+ PEYE+W +   NS  WR KY KGLG+   E+ + +F+ +   R  F    + D D+I
Sbjct: 662 YTIPEYEQWLEETPNSASWRAKYLKGLGTSKDEDARRYFKLMRKHRIAFSTIKEGDRDSI 721

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
            +AFSK +  +R+  + +FK   + D+T   I + DF+ +E IL+SMA   R IPS+ DG
Sbjct: 722 ELAFSKKRADDRKEWLRQFKPGTFLDHTQGEIGFTDFINRELILFSMADNIRSIPSVADG 781

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+++  FKR+L  EI+V +L+G+V+EH+ YHH E SL  T++ +A+D+VG  N+
Sbjct: 782 LKPVQRKVIWACFKRKLKGEIKVAQLVGHVSEHAQYHHGEQSLMMTIVNLAQDFVGGNNL 841

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NL+M NGQFGT  QGGKDHAS RYIYTEL+P +R +F   D+ L+KYL +DG  +EPE+Y
Sbjct: 842 NLMMPNGQFGTRDQGGKDHASARYIYTELSPATRAVFHPGDDPLMKYLTDDGHLIEPEYY 901

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +P +P+VL+NG  GI TGW+ +IPCYNP+DI+AN++R +  ++  PM+PW++GFKGTI K
Sbjct: 902 MPTVPMVLINGAEGIGTGWSTNIPCYNPEDIVANLRRLMAGEEQLPMLPWWRGFKGTIKK 961

Query: 365 S 365
           +
Sbjct: 962 T 962


>E9C0T0_CAPO3 (tr|E9C0T0) DNA topoisomerase 2 OS=Capsaspora owczarzaki (strain
           ATCC 30864) GN=CAOG_01720 PE=3 SV=1
          Length = 1628

 Score =  401 bits (1030), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 185/366 (50%), Positives = 257/366 (70%), Gaps = 5/366 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +E   YGR+M M DQD DGSHIKGLLINF +   PSLL +  FL E ITPI++A    G 
Sbjct: 541 VEGLRYGRLMIMTDQDSDGSHIKGLLINFLHHFWPSLLTVSGFLVEFITPIVKA--TKGK 598

Query: 61  QKLSFYSYPEYEKWWKN---WGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
           Q L+F++ P+Y++W +         W IKYYKGLG+ T +E KE+F N+++ +  F W  
Sbjct: 599 QVLTFFTVPQYQQWREEDDGRACKGWTIKYYKGLGTSTSQEAKEYFSNMDVHQIPFTWSG 658

Query: 118 DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRC 177
           ++D  AI++AFSK +  +R+  + +F++  + D+   +I Y +F+ KE IL+SMA   R 
Sbjct: 659 EDDGQAIDLAFSKKRADDRKEWLRQFRAGTFLDHQTEAITYSEFINKELILFSMADNVRS 718

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS++DG KPSQRK+L+  FKR L  EI+V +L GYVAEHSAYHH E SLA T++ MA++
Sbjct: 719 IPSVVDGFKPSQRKVLFACFKRNLKDEIKVAQLAGYVAEHSAYHHGEVSLAGTIVNMAQN 778

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           Y GS NINLL+  GQFGT +QGGKD AS RYI+T+L  ++R +FP  D+ LL YL+EDG 
Sbjct: 779 YTGSNNINLLLPLGQFGTRLQGGKDAASARYIFTKLATLTRLIFPANDDSLLNYLDEDGQ 838

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
            +EPEWY+PI+PL L+NG  GI TGW+ S+P ++P+D++ANI+  +     +PM P+Y G
Sbjct: 839 RIEPEWYMPILPLSLINGCEGIGTGWSSSVPNFSPRDVVANIRLMMAGQDPEPMCPYYNG 898

Query: 358 FKGTID 363
           F GTI+
Sbjct: 899 FTGTIE 904


>L1IRG4_GUITH (tr|L1IRG4) DNA topoisomerase 2 OS=Guillardia theta CCMP2712
           GN=GUITHDRAFT_158481 PE=3 SV=1
          Length = 1343

 Score =  400 bits (1028), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 185/364 (50%), Positives = 262/364 (71%), Gaps = 3/364 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI-QKLS 64
           YG VM MADQD DGSHIKGLLIN F+   P+LLR P FL E  TPI++A    G   +++
Sbjct: 526 YGHVMIMADQDPDGSHIKGLLINLFHYYWPNLLRHPGFLQEFATPIVKAKKKGGGKNEIA 585

Query: 65  FYSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
           F++  EYE+W +  G+    W IKYYKGLG+ + +E KE+F N+ + +  F W   ED +
Sbjct: 586 FFTLQEYEEWREQVGDGLGGWTIKYYKGLGTSSSQEAKEYFSNLPLHQMDFAWEGAEDGE 645

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I++ FSK +  +R+  +L+++   + D+    + Y DF+ KE I +SM    R IPSL+
Sbjct: 646 IIDMVFSKKRADDRKQWLLRYEEDLFVDHNGSEVTYSDFINKELIHFSMMDNMRSIPSLV 705

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKILY  FKR+L  EI+V +L GYVAEHSAYHH E SLA  ++ MA+++VGS 
Sbjct: 706 DGWKPGQRKILYACFKRKLKAEIKVAQLAGYVAEHSAYHHGEQSLAMAIVGMAQNFVGSN 765

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           N+N+L+ +GQFGT +QGG D ASPRYI+T L+PI+RFLF E D+ +LKYLN+DG S+EP+
Sbjct: 766 NVNVLVPSGQFGTRLQGGADAASPRYIFTYLHPITRFLFHEADDAILKYLNDDGQSIEPQ 825

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+PI+P VLVNG  GI TGW+  +PCYNP+D+++N+KR L  + ++PM PW++GF+G++
Sbjct: 826 FYVPILPTVLVNGAHGIGTGWSTDVPCYNPRDVVSNLKRLLRQEVMEPMHPWFRGFQGSV 885

Query: 363 DKSI 366
           + ++
Sbjct: 886 ELNV 889


>L0P818_PNEJ8 (tr|L0P818) DNA topoisomerase 2 OS=Pneumocystis jiroveci (strain
           SE8) GN=PNEJI1_003373 PE=3 SV=1
          Length = 1482

 Score =  399 bits (1024), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 190/360 (52%), Positives = 259/360 (71%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGL+IN+     PSLL IP FL E ITPI++A    G Q+ +F
Sbjct: 585 YGHLMIMTDQDHDGSHIKGLIINYLESSFPSLLEIPGFLIEFITPIVKA--TKGTQEKTF 642

Query: 66  YSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PEYE W ++  N+  W+IKYYKGLG+    + K++F +++   K F    + D + I
Sbjct: 643 FTIPEYEYWKESVDNAKGWKIKYYKGLGTSYGNDVKKYFSDLDTHLKEFHSIREGDKELI 702

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AFSK K  ER+  +  FK   Y D+T   I   DF+ KE IL+SMA   R IPS++DG
Sbjct: 703 DMAFSKKKADERKEWLRLFKPGTYMDHTLDKIPISDFINKELILFSMADNIRSIPSVVDG 762

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+++G FKR+L +EI+V +L GY++EH+AYHH E SL  T++ +A+ +VGS NI
Sbjct: 763 LKPGQRKVIFGCFKRKLKSEIKVAQLSGYISEHTAYHHGEQSLTQTIIGLAQTFVGSNNI 822

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NL+  NGQFGT +QGGKD ASPRYI+TEL+P++R +F E D+ LL YLNEDG S+EP WY
Sbjct: 823 NLMKPNGQFGTRLQGGKDAASPRYIFTELSPLTRKIFVESDDALLNYLNEDGQSIEPLWY 882

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PIIPL+LVNG  GI TGW+  IP +NP D++ NI+R +N +KL+PM PWY+GF G+I+K
Sbjct: 883 VPIIPLILVNGCEGIGTGWSSYIPNFNPIDLVNNIRRMMNGEKLEPMHPWYRGFNGSIEK 942


>M2Y981_GALSU (tr|M2Y981) DNA topoisomerase 2 OS=Galdieria sulphuraria
           GN=Gasu_00250 PE=3 SV=1
          Length = 1396

 Score =  397 bits (1021), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 183/365 (50%), Positives = 259/365 (70%), Gaps = 5/365 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG V+ M DQD DGSHIKGLLINFF+   PSLL +  FL E ITPI++A    G 
Sbjct: 501 IKTLRYGHVLIMTDQDNDGSHIKGLLINFFHHFWPSLLEVKGFLQEFITPIVKA--SKGN 558

Query: 61  QKLSFYSYPEYEKWWKNWGNSD---WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
           Q ++F++ PEY+ W  +        W IKYYKGLG+ T  E KE+F ++++    F+W  
Sbjct: 559 QVVTFFTIPEYKTWRTSLEQETLKGWTIKYYKGLGTSTAAEAKEYFSHLDLHVIDFIWSG 618

Query: 118 DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRC 177
           + D+ AI++AFSK + +ER+  +       Y D+    + Y +F+ KE IL+S++   R 
Sbjct: 619 EHDMVAIDMAFSKQRVQERKEWLADVDPDTYFDHIADDLTYSNFVNKELILFSLSDNARS 678

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS+IDG KPSQRK+L+G FK++L  +I+V +L GY+AE++AYHH E SL  T++ +A++
Sbjct: 679 IPSVIDGLKPSQRKVLFGCFKKKLTRDIKVAQLAGYIAENAAYHHGEMSLMATIVGLAQN 738

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           +VG+ NINLL+ +GQFGT +QGGKD AS RYI+T L PI+R+LFPE D+ +L YL EDG+
Sbjct: 739 FVGACNINLLVPSGQFGTRLQGGKDAASARYIFTRLAPITRYLFPEADDAVLHYLEEDGL 798

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
           S+EP +Y PIIPLVLVNG  GI TGW+ ++PCYNPKD+I NI+R ++  +   M PWY+G
Sbjct: 799 SIEPNYYCPIIPLVLVNGAEGIGTGWSTNVPCYNPKDVIENIRRLIHGHEPHTMHPWYRG 858

Query: 358 FKGTI 362
           F+G+I
Sbjct: 859 FRGSI 863


>R7SSV1_DICSQ (tr|R7SSV1) Type II DNA topoisomerase OS=Dichomitus squalens
           (strain LYAD-421) GN=DICSQDRAFT_156586 PE=4 SV=1
          Length = 1540

 Score =  397 bits (1019), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 184/360 (51%), Positives = 255/360 (70%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YGR+M M DQD+DGSHIKGLLIN+     PSLL++P FL E ITP++R +   G Q ++F
Sbjct: 606 YGRLMLMTDQDHDGSHIKGLLINYLDHFYPSLLKLPKFLVEFITPVVRVWK--GKQVINF 663

Query: 66  YSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           Y+ PEYE W +   +S  W+ KYYKGLG+   E+ +++F++++     F    + D + I
Sbjct: 664 YTIPEYEMWLEQTPDSHKWQHKYYKGLGTSKDEDARDYFRDMKRHMIPFSTSKEGDRELI 723

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
            +AFSK K  +R+  + +FK   Y D+T   I   +F+ +E IL+SMA   R IPS+ DG
Sbjct: 724 ELAFSKKKADDRKEWLRQFKPGTYLDHTQREIPLSEFINRELILFSMADNIRSIPSVADG 783

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+++  FKR L  EI+V +L+GYV+E SAYHH E+SL  T++ +A+D+VGS NI
Sbjct: 784 LKPGQRKVIWSCFKRNLKKEIKVAQLVGYVSEVSAYHHGEASLMATIINLAQDFVGSNNI 843

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLLM NGQFGT  QGGKDHA+ RYI+TEL PI R L    D+ +L Y  +DG  VEPEWY
Sbjct: 844 NLLMPNGQFGTRDQGGKDHAAARYIFTELAPIVRTLMHPADDAILTYQQDDGRQVEPEWY 903

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PI+P+VLVNG  GI TGW+ +IP YNP+DI+ANI+R +N+++ +PM+PW++GF GT+ K
Sbjct: 904 MPIVPMVLVNGAEGIGTGWSTTIPAYNPEDIVANIRRLMNNEEQEPMLPWWRGFSGTVKK 963


>K3X2K0_PYTUL (tr|K3X2K0) DNA topoisomerase 2 OS=Pythium ultimum GN=PYU1_G011424
           PE=3 SV=1
          Length = 1522

 Score =  396 bits (1017), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 190/369 (51%), Positives = 258/369 (69%), Gaps = 3/369 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
            +S  YG +M MADQD+DGSHIKGL+INF +   PSLL+I  F+ E ITPI++       
Sbjct: 594 TKSLRYGHLMIMADQDHDGSHIKGLVINFIHHFWPSLLQIDGFIQEFITPIVKCTKGKNN 653

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            K+ FY+ PEY  W +   N   W IKYYKGLG+ T +E KE+F +++  +  F +  DE
Sbjct: 654 SKV-FYTIPEYNAWREVTNNGRGWSIKYYKGLGTSTTQEAKEYFSDLKTHQVGFTYDGDE 712

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D DAI++AFSK +  ER+  +  +++  + DY    + Y +F+ KE IL+SMA   R IP
Sbjct: 713 DGDAIDMAFSKKRVEERKDWLRGYQAGTHVDYDVDDMAYSEFVNKELILFSMADNMRSIP 772

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KPSQRK+L+  FKR L  EI+V +L GYV+EHSAYHH E SL  T++ MA+D+V
Sbjct: 773 SVVDGFKPSQRKVLFCCFKRNLKVEIKVAQLAGYVSEHSAYHHGEQSLNGTIINMAQDFV 832

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS N++LL  NGQFGT + GGKD ASPRYI+T L  ++R +F  +DN +L YL++DG S+
Sbjct: 833 GSNNVHLLSPNGQFGTRLMGGKDAASPRYIFTNLEQVARRIFDPLDNDVLNYLDDDGQSI 892

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP++Y+PIIP+ LVNG  GI TGW+ SIP YNP DII N+++ LN + L P+VPWY+GF 
Sbjct: 893 EPDFYVPIIPMALVNGSEGIGTGWSSSIPNYNPLDIIKNLRQKLNGEDLSPLVPWYRGFS 952

Query: 360 G-TIDKSIG 367
           G  I+KS G
Sbjct: 953 GHIIEKSSG 961


>K5XBZ3_PHACS (tr|K5XBZ3) DNA topoisomerase 2 OS=Phanerochaete carnosa (strain
           HHB-10118-sp) GN=PHACADRAFT_83842 PE=3 SV=1
          Length = 1551

 Score =  395 bits (1016), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 178/361 (49%), Positives = 254/361 (70%), Gaps = 3/361 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG++M M DQD+DGSHIKGL++N+     PSLL+IP FL E +TPI+R     G QK++F
Sbjct: 600 YGQLMIMTDQDHDGSHIKGLILNYLDHFYPSLLKIPKFLVEFVTPIVRV--TKGNQKINF 657

Query: 66  YSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PEYE+W +N  +S  W+ KYYKGLG+   E+ +E+F  +      F    D + D I
Sbjct: 658 FTIPEYEQWLENTPDSHKWKSKYYKGLGTSKDEDAREYFSRMNKHMIPFATVKDGERDLI 717

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AFSK K  +R+  +   +   Y D+    I   DF+ +E IL+S A   R IPS+ DG
Sbjct: 718 DLAFSKKKADDRKEWLRNLEPGTYLDHNTREISVSDFINRELILFSYADNVRSIPSVADG 777

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+++G FKR+L  EI+V +L+GY++E +AYHH E SL  T++ +A+D++GS N+
Sbjct: 778 LKPGQRKVIWGCFKRKLKNEIKVAQLVGYISEKAAYHHGEQSLMMTIVNLAQDFIGSNNV 837

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLLM NGQFGT  QGGKDHAS RYI+TE +P++R L    D+ LL YL +D   +EPEWY
Sbjct: 838 NLLMPNGQFGTRDQGGKDHASARYIFTEPSPMARVLLHSGDDPLLNYLKDDTTDIEPEWY 897

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +P++PL+LVNG  GI TGW+ ++PCYNP DI+ANI+R +N +++ PM+PW++GF+GTI K
Sbjct: 898 MPVLPLILVNGAEGIGTGWSTNVPCYNPVDIVANIRRRMNGEEMVPMLPWWRGFRGTIKK 957

Query: 365 S 365
           +
Sbjct: 958 T 958


>M7NQN5_9ASCO (tr|M7NQN5) Uncharacterized protein OS=Pneumocystis murina B123
           GN=PNEG_00635 PE=4 SV=1
          Length = 1522

 Score =  395 bits (1016), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 189/360 (52%), Positives = 258/360 (71%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGL+IN+     PSLL IP FL E ITPI++A    G Q+ +F
Sbjct: 628 YGHLMIMTDQDHDGSHIKGLIINYLESSFPSLLEIPGFLIEFITPIVKA--TKGSQEKTF 685

Query: 66  YSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PEYE W ++  N+  W+IKYYKGLG+    + K++F +++   K F    + D + I
Sbjct: 686 FTIPEYEYWKESTDNAKGWKIKYYKGLGTSYGNDVKKYFSDLDTHLKEFHSIQEGDKELI 745

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AFSK K  ER+  +  FK   Y D+T   I   DF+ KE IL+SMA   R IPS++DG
Sbjct: 746 DMAFSKKKADERKEWLRHFKPGTYMDHTLDKIPISDFINKELILFSMADNIRSIPSVVDG 805

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK++YG FKR+L +EI+V +L GY++EH+AYHH E SL  T++ +A+ +VGS NI
Sbjct: 806 LKPGQRKVIYGCFKRKLKSEIKVAQLSGYISEHTAYHHGEQSLTQTIIGLAQTFVGSNNI 865

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NL+  NGQFGT +QGGKD ASPRYI+TEL+P++R +F E D+ LL YLN+DG S+EP WY
Sbjct: 866 NLMKPNGQFGTRLQGGKDAASPRYIFTELSPLTRKIFIESDDALLDYLNDDGQSIEPVWY 925

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PIIPL+LVNG  GI TGW+  IP +NP D++ NI+R +N ++L+PM PWY+GF G I+K
Sbjct: 926 VPIIPLILVNGSEGIGTGWSSYIPNFNPIDLVDNIRRMMNGEELRPMHPWYRGFNGIIEK 985


>E0S6I5_ENCIT (tr|E0S6I5) DNA topoisomerase 2 OS=Encephalitozoon intestinalis
           (strain ATCC 50506) GN=Eint_040290 PE=3 SV=1
          Length = 1141

 Score =  394 bits (1012), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 185/364 (50%), Positives = 258/364 (70%), Gaps = 4/364 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPI+RA     +
Sbjct: 492 VSSLRYGHIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIVRASKKGEV 551

Query: 61  QKLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +   F++ PEYE++ KN  +  W IKYYKGLG+ T  + K++F N+ I  KYF    +ED
Sbjct: 552 K--DFFTLPEYEEFKKN--SDGWNIKYYKGLGTSTSADAKQYFSNLPIHVKYFTPLIEED 607

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            + I++AF+K K   R+  +L F+   + D +   I   DF+ KE IL+SMA   R IPS
Sbjct: 608 KELIDLAFNKKKADARKTWLLNFEPGTFLDQSQPQISISDFVNKELILFSMADNIRSIPS 667

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KP QRK+++  FKR L +EI+V +L+GYV+E SAYHH E SL +T++ +A+D+VG
Sbjct: 668 LVDGLKPGQRKVMFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQDFVG 727

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+  GQFG+ +QGGKD ASPRYI+T L+P++R +F E D+ +L YLN+D +S+E
Sbjct: 728 SNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRLIFNENDDAILSYLNDDNLSIE 787

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PE+Y+PIIP+VLVNG  GI TGW+ SIP +NP D++ NI+R +  +    M+P+Y+ F+G
Sbjct: 788 PEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRLIRGEDPVEMIPYYRNFRG 847

Query: 361 TIDK 364
           TI+K
Sbjct: 848 TIEK 851


>I6UKY3_ENCHA (tr|I6UKY3) DNA topoisomerase 2 OS=Encephalitozoon hellem (strain
           ATCC 50504) GN=EHEL_040280 PE=3 SV=1
          Length = 1144

 Score =  394 bits (1011), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 189/362 (52%), Positives = 255/362 (70%), Gaps = 4/362 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPIIRA     ++ 
Sbjct: 494 SLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRATKKGQVR- 552

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             F++ PEYE++ K+     W IKYYKGLG+ T  + K++F N+ I  K F    DED +
Sbjct: 553 -DFFTLPEYEEFKKS--EEGWNIKYYKGLGTSTSADAKQYFSNLPIHVKNFTPLVDEDKE 609

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I++AF+K K   R+  +L F+   + D +   I   DF+ KE IL+SMA   R IPSL+
Sbjct: 610 LIDLAFNKKKADARKTWLLSFEPGTFLDQSLPQISISDFVNKELILFSMADNIRSIPSLV 669

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRK+++  FKR L +EI+V +L+GYV+E SAYHH E SL +T++ +A+D+VGS 
Sbjct: 670 DGLKPGQRKVMFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQDFVGSN 729

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL+  GQFG+ +QGGKD ASPRYI+T L+P++R +F E D+ +L YLN+D +S+EPE
Sbjct: 730 NINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRLIFNENDDAILNYLNDDNLSIEPE 789

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+PIIP+VLVNG  GI TGW+ SIP +NP DII NI+R + D+    M P+Y+ F+GTI
Sbjct: 790 FYVPIIPMVLVNGAEGIGTGWSTSIPNFNPIDIIENIRRMIRDEDPVEMTPYYRNFRGTI 849

Query: 363 DK 364
           +K
Sbjct: 850 EK 851


>I0YZH1_9CHLO (tr|I0YZH1) DNA topoisomerase 2 OS=Coccomyxa subellipsoidea C-169
           GN=COCSUDRAFT_36592 PE=3 SV=1
          Length = 1189

 Score =  393 bits (1010), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 183/359 (50%), Positives = 252/359 (70%), Gaps = 3/359 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGL++NF +   PSLL++  FL E ITPI++     G QKLSF
Sbjct: 520 YGHLMIMTDQDHDGSHIKGLIMNFLHHFYPSLLKVKGFLLEFITPIVKV--SKGKQKLSF 577

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++ PEYE W K+  +  W IKYYKGLG+   +E +E+F  ++  RK FV+  +ED  AI 
Sbjct: 578 FTMPEYEAWKKS-ASPGWTIKYYKGLGTSDKKEAQEYFAGIDQHRKSFVYTGEEDDQAIE 636

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK K  ER+  +  F+   Y D +   I Y DF+ KE IL+S A + R IP+++DG 
Sbjct: 637 LAFSKKKIEERKQWLAGFEPGTYLDQSVDEISYSDFVNKELILFSRADLERSIPNMVDGL 696

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRKIL+  FKR +  +++V +L G+V+  +AYHH E+SL +T++ +A +++GS N+N
Sbjct: 697 KPGQRKILFCCFKRNIRRDVKVAQLSGFVSADTAYHHGEASLQSTIIGLAHNFIGSNNVN 756

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
           LL+  GQFGT +QGGKD A  RYI T L+PI+R +F E D+KLL YL E+G S+EP WYL
Sbjct: 757 LLVPQGQFGTRLQGGKDAAGARYIMTRLDPIARVVFHEHDDKLLDYLKEEGQSIEPHWYL 816

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R L  +++  M PWY GFKGTI +
Sbjct: 817 PILPMVLVNGAEGIGTGWSTYIPNYNPRDIVANLRRLLAGEEVVAMQPWYNGFKGTIQE 875


>B6AEK2_CRYMR (tr|B6AEK2) DNA topoisomerase 2 OS=Cryptosporidium muris (strain
            RN66) GN=CMU_012930 PE=3 SV=1
          Length = 1645

 Score =  392 bits (1007), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 186/361 (51%), Positives = 255/361 (70%), Gaps = 6/361 (1%)

Query: 6    YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
            YG +M M DQD+DGSHIKGL+IN  +   PSL+    FL + +TPI++A   N  Q+LSF
Sbjct: 654  YGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLVHFNGFLKQFVTPIVKAKKGN--QELSF 711

Query: 66   YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
            ++  EY+KW K      W+IKYYKGLG+ T  E KE+F N+E     F W NDED +AI+
Sbjct: 712  FTLVEYDKWRKESNPHGWKIKYYKGLGTSTDLEFKEYFTNIENHSIEFDWYNDEDDEAID 771

Query: 126  IAFSKSKTRERRGLMLKFKSSDYRDYTDLSIC----YKDFLQKEFILYSMASVRRCIPSL 181
            +AFSK +T +R+  +  ++   Y DY+  +IC    Y+DF+ KE +L+S     R IP++
Sbjct: 772  MAFSKKRTEDRKKWIESYQEGTYIDYSMDNICRSLRYRDFIDKELVLFSRYDTARSIPNV 831

Query: 182  IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
            IDG KP QRK+LY  FK++L  E++V +L GYVAEHSAYHH E+SL +T++ MA+D+VGS
Sbjct: 832  IDGLKPGQRKVLYSVFKKKLNNEMKVAQLAGYVAEHSAYHHGEASLQSTIVNMAQDFVGS 891

Query: 242  MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
             N+NLL   GQFG+  +GGKD ++ RYI+T+L+  +R++FPE D+ LL YL +DG  +EP
Sbjct: 892  NNLNLLQPCGQFGSRKEGGKDASAARYIFTKLSTWTRYIFPEADDPLLIYLQDDGQQIEP 951

Query: 302  EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
             +Y+PIIP+VLVNG  GI TGW+CS+P YNPKDII N+KR L  D + PM PWY+ FKG 
Sbjct: 952  LFYVPIIPMVLVNGADGIGTGWSCSVPNYNPKDIINNLKRALRGDIMMPMTPWYRSFKGK 1011

Query: 362  I 362
            +
Sbjct: 1012 V 1012


>M1KJ03_ENCCN (tr|M1KJ03) DNA topoisomerase 2 OS=Encephalitozoon cuniculi
           GN=ECU04_0350 PE=3 SV=1
          Length = 1144

 Score =  391 bits (1005), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 186/364 (51%), Positives = 253/364 (69%), Gaps = 4/364 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG VM M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPIIRA     +
Sbjct: 492 VSSLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRATKKGQV 551

Query: 61  QKLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +   F++ PEYE++ KN     W IKYYKGLG+ T  + K++F N+ +  K F     ED
Sbjct: 552 R--DFFTLPEYEEFKKN--EDGWNIKYYKGLGTSTSADAKQYFSNLPVHVKSFTPLAAED 607

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            + I++AF+K K   R+  +L F    + D +   I   DF+ KE IL+SMA   R IPS
Sbjct: 608 KELIDLAFNKKKADARKTWLLNFAPGTFLDQSQTQISISDFVNKELILFSMADNIRSIPS 667

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KP QRK+++  FKR L +EI+V +L+GYV+E SAYHH E SL +T++ +A+D+VG
Sbjct: 668 LVDGLKPGQRKVIFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQDFVG 727

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+  GQFG+ +QGGKD ASPRYI+T L+P++R +F E D+ +L YLN+D  S+E
Sbjct: 728 SNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRMIFNENDDAILNYLNDDNFSIE 787

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PE+Y+PIIP+VLVNG  GI TGW+ SIP +NP D++ NI+R +  +    MVP+Y+ F+G
Sbjct: 788 PEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRMIRGEDPVEMVPYYRNFRG 847

Query: 361 TIDK 364
           TI+K
Sbjct: 848 TIEK 851


>Q8SS63_ENCCU (tr|Q8SS63) DNA topoisomerase 2 OS=Encephalitozoon cuniculi (strain
           GB-M1) GN=ECU04_0350 PE=3 SV=1
          Length = 1144

 Score =  391 bits (1005), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 186/364 (51%), Positives = 253/364 (69%), Gaps = 4/364 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG VM M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPIIRA     +
Sbjct: 492 VSSLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRATKKGQV 551

Query: 61  QKLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +   F++ PEYE++ KN     W IKYYKGLG+ T  + K++F N+ +  K F     ED
Sbjct: 552 R--DFFTLPEYEEFKKN--EDGWNIKYYKGLGTSTSADAKQYFSNLPVHVKSFTPLAAED 607

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            + I++AF+K K   R+  +L F    + D +   I   DF+ KE IL+SMA   R IPS
Sbjct: 608 KELIDLAFNKKKADARKTWLLNFAPGTFLDQSQTQISISDFVNKELILFSMADNIRSIPS 667

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KP QRK+++  FKR L +EI+V +L+GYV+E SAYHH E SL +T++ +A+D+VG
Sbjct: 668 LVDGLKPGQRKVIFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQDFVG 727

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+  GQFG+ +QGGKD ASPRYI+T L+P++R +F E D+ +L YLN+D  S+E
Sbjct: 728 SNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRMIFNENDDAILNYLNDDNFSIE 787

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PE+Y+PIIP+VLVNG  GI TGW+ SIP +NP D++ NI+R +  +    MVP+Y+ F+G
Sbjct: 788 PEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRMIRGEDPVEMVPYYRNFRG 847

Query: 361 TIDK 364
           TI+K
Sbjct: 848 TIEK 851


>I7ADX3_ENCRO (tr|I7ADX3) DNA topoisomerase 2 OS=Encephalitozoon romaleae (strain
           SJ-2008) GN=EROM_040310 PE=3 SV=1
          Length = 1144

 Score =  389 bits (1000), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 185/362 (51%), Positives = 256/362 (70%), Gaps = 4/362 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPIIRA     ++ 
Sbjct: 494 SLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRATKKGQVR- 552

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             F++ PEYE++ ++     W IKYYKGLG+ T  + K++F N+ I  K+F    DED +
Sbjct: 553 -DFFTLPEYEEFKRS--EEGWNIKYYKGLGTSTSADAKQYFSNLPIHVKHFTPLVDEDKE 609

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I++AF+K K   R+  +L F+   + D +   I   DF+ KE IL+SMA   R IPSL+
Sbjct: 610 LIDLAFNKKKADARKTWLLSFEPGTFLDQSLSHISISDFVNKELILFSMADNIRSIPSLV 669

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRK+++  FKR L +EI+V +L+GYV+E SAYHH E SL +T++ +A+D+VGS 
Sbjct: 670 DGLKPGQRKVMFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQDFVGSN 729

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL+  GQFG+ +QGGKD ASPRYI+T L+P++R +F E D+ +L YLN+D +S+EPE
Sbjct: 730 NINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRLIFNENDDAILNYLNDDNLSIEPE 789

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+PIIP+VLVNG  GI TGW+ SIP +NP D++ NI+R +  +    MVP+Y+ F+G+I
Sbjct: 790 FYVPIIPMVLVNGAEGIGTGWSTSIPNFNPIDVVENIRRMIRGEDPVEMVPYYRNFRGSI 849

Query: 363 DK 364
           +K
Sbjct: 850 EK 851


>J9HZI4_9SPIT (tr|J9HZI4) DNA topoisomerase 2 OS=Oxytricha trifallax
           GN=OXYTRI_06696 PE=3 SV=1
          Length = 1410

 Score =  389 bits (1000), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 181/363 (49%), Positives = 257/363 (70%), Gaps = 2/363 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG++M M DQD+DGSHIKGLLINF +   P+L+R   F+ E +TPII+A   N +   SF
Sbjct: 519 YGKLMIMTDQDHDGSHIKGLLINFIHFFWPTLMRNNGFVREFVTPIIKATKGNEV--YSF 576

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++ PEYE+W        W+IKYYKGLG+ + +E KE+F  ++  +  F + ++ED + I+
Sbjct: 577 FTIPEYEQWADGRNLKGWKIKYYKGLGTSSAKEAKEYFSAIDNHQIEFEYVDNEDEEVID 636

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AF+K    +R+  +  +++  Y D++   + YKDF+ KE IL+S+A   R IP+L DG 
Sbjct: 637 LAFNKKLADKRKDWLTTYRTDLYVDHSQTHLRYKDFVNKELILFSVADCLRSIPNLCDGL 696

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRKIL+  FK++L  EI+V +L+GYV E+SAYHH E SL  T++ MA+++VGS NIN
Sbjct: 697 KPGQRKILFCVFKKKLKDEIKVAQLVGYVGENSAYHHGEQSLCQTIITMAQNFVGSNNIN 756

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
           LL+  GQFGT  QGGK+ ASPRYI+T LNP++R +FP+ D+ +L YL E+G S+EP++YL
Sbjct: 757 LLLPLGQFGTRNQGGKEAASPRYIFTNLNPVTRTIFPQEDDAVLNYLEEEGQSIEPDYYL 816

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDKS 365
           PIIP+ LVNG  GI TGW+  IPC+NPKDI+ N+KR +  +  Q M PWYKG+ G+I+  
Sbjct: 817 PIIPMCLVNGAEGIGTGWSTFIPCHNPKDIVDNLKRMMKGEPYQTMRPWYKGYLGSIETL 876

Query: 366 IGG 368
            GG
Sbjct: 877 QGG 879


>M1HX85_9PHYC (tr|M1HX85) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CVB-1 GN=CVB-1_758L PE=3 SV=1
          Length = 1058

 Score =  388 bits (997), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 187/367 (50%), Positives = 254/367 (69%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W KN  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKKNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPVTRQVFNQTDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYKGF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMTPWYKGFTGT 831

Query: 362 IDKSIGG 368
           ID++  G
Sbjct: 832 IDQNDNG 838


>R9AGH6_WALIC (tr|R9AGH6) DNA topoisomerase 2 OS=Wallemia ichthyophaga EXF-994
           GN=J056_004105 PE=4 SV=1
          Length = 1422

 Score =  388 bits (997), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 184/360 (51%), Positives = 253/360 (70%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLIN+F    PSLL+IP FL E ITPII+ F  N  Q++SF
Sbjct: 586 YGSIMIMTDQDHDGSHIKGLLINYFDTFYPSLLKIPNFLVEFITPIIKVFKRN--QEVSF 643

Query: 66  YSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PE+E W  +N     WR+KYYKGLG+ + EE +++F+ +E  R  F    D D + I
Sbjct: 644 FTVPEFENWKAQNDDGRGWRLKYYKGLGTSSDEEARQYFKALERHRIPFTSTQDGDRELI 703

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AF+K +T +R+  +  +    Y D+    I YKDF+ KE IL+SMA   R IPS++DG
Sbjct: 704 DMAFNKKRTEDRKEWLRGYTPGTYLDHDIDEITYKDFVNKELILFSMADNARSIPSMVDG 763

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+LYG  KR L +EI+V +L   VAE+++YHH E SL  T++ MA+ YVGS N+
Sbjct: 764 FKPGQRKVLYGTIKRNLKSEIKVAQLGMSVAENTSYHHGEQSLIQTIVGMAQSYVGSNNL 823

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           N+L  NGQFG+  +GGKD A+ RYI+T +  I+R +F   D+ +L YL ED   +EPEWY
Sbjct: 824 NILSPNGQFGSRREGGKDSAAARYIFTAIPRITRTVFHPNDDPILTYLKEDDEWIEPEWY 883

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PIIP+VLVNG  GI TGW+ +IP YNP D++ANI+R LN+ ++QPM+PWY+GF G I++
Sbjct: 884 VPIIPMVLVNGADGIGTGWSTTIPNYNPADLVANIRRKLNNQEMQPMIPWYRGFTGNIEQ 943


>F0WKX4_9STRA (tr|F0WKX4) DNA topoisomerase 2 OS=Albugo laibachii Nc14
           GN=AlNc14C138G7164 PE=3 SV=1
          Length = 1499

 Score =  386 bits (992), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 188/368 (51%), Positives = 251/368 (68%), Gaps = 4/368 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M MADQD+DGSHIKGL+INF +   PSLL++  F+ E ITPI++     G +
Sbjct: 565 KSLRYGHLMIMADQDHDGSHIKGLVINFIHHFWPSLLQVEGFMHEFITPIVKC--AKGSK 622

Query: 62  KLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           K  FY+ PEYE W     N   WRIKYYKGLG+ T EE KE+F ++   +  F ++ +ED
Sbjct: 623 KEVFYTMPEYEAWRLATNNGQGWRIKYYKGLGTSTTEEAKEYFSDLATHQIDFSYKGEED 682

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            D+I++AFSK +  ER+  +  +    + DY    + Y +F+ KE IL+S A   R IP 
Sbjct: 683 GDSIDMAFSKKRVEERKNWLRGYTPGTHVDYNIADMPYSEFVNKELILFSRADNMRSIPC 742

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KPSQRK+LY  FKR L  EI+V +L GYV+EHS+YHH E+SL  T++ MA+D++G
Sbjct: 743 LVDGFKPSQRKVLYCCFKRNLRVEIKVAQLAGYVSEHSSYHHGEASLHGTIINMAQDFIG 802

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S N NLL  NGQFGT I GGKD ASPRYI+T+L  I+   F   DN LL YL+EDG  +E
Sbjct: 803 SNNSNLLSPNGQFGTRILGGKDAASPRYIFTKLEAIAYKFFDPNDNSLLNYLDEDGQLIE 862

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIK-RFLNDDKLQPMVPWYKGFK 359
           PEWY+P+IP+VLVNG  GI TGW+  IP YNP D+I N++ R   +   +P+VPWY+GF 
Sbjct: 863 PEWYVPVIPMVLVNGSEGIGTGWSSFIPNYNPLDLIENLRARIKGEAPTKPLVPWYRGFT 922

Query: 360 GTIDKSIG 367
           G+I++  G
Sbjct: 923 GSIEERSG 930


>M2RR97_CERSU (tr|M2RR97) DNA topoisomerase 2 OS=Ceriporiopsis subvermispora B
           GN=CERSUDRAFT_109994 PE=3 SV=1
          Length = 1522

 Score =  386 bits (991), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 177/360 (49%), Positives = 254/360 (70%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG++M MADQD+DGSHIKGLL+N+     PSLL+IP F  E ITPI+R     G +K+ F
Sbjct: 603 YGKLMIMADQDHDGSHIKGLLLNYLDHFYPSLLKIPGFFLEFITPIVRV--SKGDKKVDF 660

Query: 66  YSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PEY++W +N  NS  W++KYYKGLG+    + +E+F+N+      F    + D + I
Sbjct: 661 FTVPEYQQWVENTPNSHTWKVKYYKGLGTSVDSDAREYFKNMRKHMIPFAPTEEGDHELI 720

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
            +AFSK K  ER+  + +F+   + ++    I + DF+ +E IL+SMA   R IPS+ DG
Sbjct: 721 EMAFSKKKADERKEWLRQFRPGTFLNHDQRQIKFSDFINRELILFSMADNIRSIPSVADG 780

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+L+  FKR L +EI+V +L+GYV+EH+ YHH E SL  T++ +A+D+VGS N+
Sbjct: 781 LKPGQRKVLWSCFKRGLKSEIKVAQLVGYVSEHAQYHHGEMSLMQTIVNLAQDFVGSNNM 840

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           N+LM NGQFGT  QGGKDHAS RYI+TE +PI+R +F   D+ L+ +  ED   VEP++Y
Sbjct: 841 NILMPNGQFGTRDQGGKDHASARYIFTEPSPITRKVFHPADDPLMNFQTEDNHVVEPDYY 900

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           LP++P++L+NG  GI TGW+ S+P YNP+DI+ANI+R +  ++  PM+PW++GFKGTI K
Sbjct: 901 LPVLPMILINGAEGIGTGWSTSVPSYNPEDIVANIRRLMAGEEQVPMLPWWRGFKGTIKK 960


>M1I6I8_9PHYC (tr|M1I6I8) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus NW665.2 GN=NW665.2_626R PE=3 SV=1
          Length = 1058

 Score =  384 bits (987), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 186/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I +
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDINE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W KN  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKKNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPATRQVFNQADDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWY+GF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMSPWYRGFTGT 831

Query: 362 IDKSIGG 368
           ID++  G
Sbjct: 832 IDQNDNG 838


>D2UZM0_NAEGR (tr|D2UZM0) DNA topoisomerase 2 OS=Naegleria gruberi
           GN=NAEGRDRAFT_29557 PE=3 SV=1
          Length = 1457

 Score =  384 bits (985), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 182/365 (49%), Positives = 252/365 (69%), Gaps = 2/365 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M MADQD+DGSHIKGLLINF +   PSLL+IP FL E ITPI++A +    
Sbjct: 539 IKSLRYGSIMIMADQDHDGSHIKGLLINFIHKFWPSLLKIPGFLKEFITPIVKATNNRTK 598

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           + ++F+S PEYE W +   ++  W IKYYKGLG+ T  E KE+F N+ + +K F +  D 
Sbjct: 599 KAVTFFSIPEYETWKEGLSDTKGWTIKYYKGLGTSTAPEAKEYFSNMSLHQKRFKYDTDC 658

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D   I   FSK+ T ER+  +   +   Y D++   I Y DF+ KE IL+S A  +R IP
Sbjct: 659 D-KKITSVFSKAATDERKEWLNNHQEGTYIDHSKKEISYTDFIDKELILFSKADCKRSIP 717

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+  FKR L  EI+V +L GYV+E SAYHH E SL  T++ MA+++V
Sbjct: 718 SIVDGLKPGQRKILFSCFKRNLKKEIKVAQLAGYVSEQSAYHHGEDSLNGTVVNMAQNFV 777

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL   G FGT +QGGKD ASPRYI+T+L+ I+R++FP+ D+ +L+YL++DG S+
Sbjct: 778 GSNNINLLYPGGMFGTRLQGGKDSASPRYIFTKLSEITRYIFPKADDPVLEYLDDDGQSI 837

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP +Y+PI+P+VLVNG  GI T W+ +I  YNP DI+  +K  +  ++ +   PWYKGF 
Sbjct: 838 EPRFYVPILPMVLVNGSEGIGTAWSTNIETYNPVDIVEGLKALIKGEEAKEFHPWYKGFD 897

Query: 360 GTIDK 364
           G I++
Sbjct: 898 GIIER 902


>A8N230_COPC7 (tr|A8N230) DNA topoisomerase 2 OS=Coprinopsis cinerea (strain
           Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
           GN=CC1G_03723 PE=3 SV=2
          Length = 1557

 Score =  384 bits (985), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 174/361 (48%), Positives = 250/361 (69%), Gaps = 3/361 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YGR+M M DQD+DGSHIKGL+INF     PSLL+IP FL E +TPI+R    N ++ 
Sbjct: 590 SLRYGRLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPDFLVEFVTPIVRVKKGNKVK- 648

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             F++ PEYE+W +   ++  W  KYYKGLG+   ++ +E+F  +E     F    + D 
Sbjct: 649 -DFFTIPEYEQWLEETPDARKWESKYYKGLGTSEDKDAREYFSKMEKHMIPFAPTQEGDR 707

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I++AFSK K  ER+  + +FK   + D+    I Y +F+ KE IL+SMA   R IPS+
Sbjct: 708 ELIDLAFSKKKADERKEWLRQFKPGTFLDHRLEEIPYSEFINKELILFSMADNVRSIPSI 767

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
            DG KP QRK+++G FKR+L  EI+V +L+GY++EH+AYHH E+SLA T++ +A+DYVGS
Sbjct: 768 ADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAATIINLAQDYVGS 827

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+ LL  NGQ+GT   GGKDHA+PRYI+T    I+R ++   D+ LL YL +D + +EP
Sbjct: 828 NNLALLSPNGQYGTREIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKDDDVPIEP 887

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P +P+VL+NG  GI TGW+ +IP YNP DI+AN++R + +++ +PM PW++GFKG 
Sbjct: 888 EWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEEPEPMTPWWRGFKGE 947

Query: 362 I 362
           +
Sbjct: 948 V 948


>A1IGC8_COPCI (tr|A1IGC8) DNA topoisomerase 2 OS=Coprinopsis cinerea GN=topII
           PE=2 SV=1
          Length = 1569

 Score =  384 bits (985), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 174/361 (48%), Positives = 250/361 (69%), Gaps = 3/361 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YGR+M M DQD+DGSHIKGL+INF     PSLL+IP FL E +TPI+R    N ++ 
Sbjct: 605 SLRYGRLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPDFLVEFVTPIVRVKKGNKVK- 663

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             F++ PEYE+W +   ++  W  KYYKGLG+   ++ +E+F  +E     F    + D 
Sbjct: 664 -DFFTIPEYEQWLEEAPDARKWESKYYKGLGTSEDKDAREYFSKMEKHMIPFAPTQEGDR 722

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I++AFSK K  ER+  + +FK   + D+    I Y +F+ KE IL+SMA   R IPS+
Sbjct: 723 ELIDLAFSKKKADERKEWLRQFKPGTFLDHRLEEIPYSEFINKELILFSMADNVRSIPSI 782

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
            DG KP QRK+++G FKR+L  EI+V +L+GY++EH+AYHH E+SLA T++ +A+DYVGS
Sbjct: 783 ADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAATIINLAQDYVGS 842

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+ LL  NGQ+GT   GGKDHA+PRYI+T    I+R ++   D+ LL YL +D + +EP
Sbjct: 843 NNLALLSPNGQYGTREIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKDDDVPIEP 902

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P +P+VL+NG  GI TGW+ +IP YNP DI+AN++R + +++ +PM PW++GFKG 
Sbjct: 903 EWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEEPEPMTPWWRGFKGE 962

Query: 362 I 362
           +
Sbjct: 963 V 963


>Q5KSK9_COPCI (tr|Q5KSK9) DNA topoisomerase 2 OS=Coprinopsis cinerea GN=CoTopII
           PE=2 SV=1
          Length = 1572

 Score =  383 bits (984), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 174/361 (48%), Positives = 250/361 (69%), Gaps = 3/361 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YGR+M M DQD+DGSHIKGL+INF     PSLL+IP FL E +TPI+R    N ++ 
Sbjct: 605 SLRYGRLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPDFLVEFVTPIVRVKKGNKVK- 663

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             F++ PEYE+W +   ++  W  KYYKGLG+   ++ +E+F  +E     F    + D 
Sbjct: 664 -DFFTIPEYEQWLEETPDARKWESKYYKGLGTSEDKDAREYFSKMEKHMIPFAPTQEGDR 722

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I++AFSK K  ER+  + +FK   + D+    I Y +F+ KE IL+SMA   R IPS+
Sbjct: 723 ELIDLAFSKKKADERKEWLRQFKPGTFLDHRLEEIPYSEFINKELILFSMADNVRSIPSI 782

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
            DG KP QRK+++G FKR+L  EI+V +L+GY++EH+AYHH E+SLA T++ +A+DYVGS
Sbjct: 783 ADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAATIINLAQDYVGS 842

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+ LL  NGQ+GT   GGKDHA+PRYI+T    I+R ++   D+ LL YL +D + +EP
Sbjct: 843 NNLALLSPNGQYGTREIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKDDDVPIEP 902

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P +P+VL+NG  GI TGW+ +IP YNP DI+AN++R + +++ +PM PW++GFKG 
Sbjct: 903 EWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEEPEPMTPWWRGFKGE 962

Query: 362 I 362
           +
Sbjct: 963 V 963


>M1HSV9_9PHYC (tr|M1HSV9) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus Fr5L GN=Fr5L_632R PE=3 SV=1
          Length = 1058

 Score =  383 bits (983), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 186/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I +
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDINE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ I GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRILGGKDCASARYIFTKLSPVTRQVFNQSDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYKGF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMMPMTPWYKGFTGT 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>F4R8C9_MELLP (tr|F4R8C9) DNA topoisomerase 2 OS=Melampsora larici-populina
           (strain 98AG31 / pathotype 3-4-7) GN=MELLADRAFT_46846
           PE=3 SV=1
          Length = 1259

 Score =  382 bits (982), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 182/368 (49%), Positives = 248/368 (67%), Gaps = 3/368 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           ES  YG +M M DQD+DGSHIKGL+INF     PSLL IP FL E ITPI++       Q
Sbjct: 621 ESLRYGSLMIMTDQDHDGSHIKGLIINFLDYFFPSLLEIPGFLVEFITPIVKVTRKK--Q 678

Query: 62  KLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +LSF++ PE+E+W  +N G  +W+ KYYKGLG+   ++ K++F  +   R  F      D
Sbjct: 679 ELSFFTMPEFERWKEENNGGREWKSKYYKGLGTSDAKDAKKYFSKMSSHRIKFAPTQPTD 738

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            D I++AF+K K   R+  +  F+   + D+    I Y +F+ KE IL+SMA   R IPS
Sbjct: 739 RDLIDMAFNKKKADNRKEWLRGFEPGTHLDHNVSQISYTEFINKELILFSMADNIRSIPS 798

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRK+L+  FKR+L  EI+V +L GY AEHSAYHH E SL  T++ +A+++VG
Sbjct: 799 MVDGFKPGQRKVLFACFKRKLKAEIKVAQLGGYCAEHSAYHHGEQSLTQTIVALAQNFVG 858

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NIN+L  NGQFGT   GGKD AS RYI+T +  I+R +FP  D+ +L YLN+DG  +E
Sbjct: 859 SNNINVLSPNGQFGTRANGGKDAASARYIFTNIEKITRAIFPPQDDHVLNYLNDDGAQIE 918

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWY+P++P+VLVNG SGI TGW+  IP YNP DI+ N++R L+D+ L+P+ PW++GF G
Sbjct: 919 PEWYVPVLPMVLVNGSSGIGTGWSSDIPNYNPMDIVENLRRKLSDEPLEPIYPWFRGFTG 978

Query: 361 TIDKSIGG 368
            I     G
Sbjct: 979 HITPEAPG 986


>B7XIW3_ENTBH (tr|B7XIW3) DNA topoisomerase 2 OS=Enterocytozoon bieneusi (strain
           H348) GN=EBI_23976 PE=3 SV=1
          Length = 1159

 Score =  382 bits (980), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 186/369 (50%), Positives = 258/369 (69%), Gaps = 5/369 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG +M M DQD+DGSHIKGL+INF     PSLL+I  FL E ITPI+RA      +K
Sbjct: 491 SLRYGHIMIMTDQDFDGSHIKGLIINFLDYFFPSLLKILGFLQEFITPIVRA--TKKKEK 548

Query: 63  LSFYSYPEYEKWWKNW---GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
             F++ PEYEK+ +      +S W IKYYKGLG+ T ++ K++F N+++  K F+    E
Sbjct: 549 YDFFTIPEYEKFKQQIEQIKDSGWVIKYYKGLGTSTTDDAKQYFNNLKLHVKTFIPVELE 608

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D + I++AF+K K  +R+  + +F+   + D +  +I  +DF+ KE IL+SMA   R IP
Sbjct: 609 DRELIDLAFNKKKADDRKEWIGRFEPGTFLDQSMSNITVRDFVNKELILFSMADNIRSIP 668

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S+IDG KP QRK+++  FKR L TEI+V +L+GYV+EHSAYHH E+SLA T++ +A D+V
Sbjct: 669 SVIDGLKPGQRKVIFSCFKRNLKTEIKVAQLVGYVSEHSAYHHGEASLAATIINLAHDFV 728

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL+  GQFG+ + GGKD ASPRYI+T LNP+SR +F E D  +L+   ED + +
Sbjct: 729 GSNNINLLLPLGQFGSRLLGGKDSASPRYIFTNLNPLSRLIFHEHDIPILESQIEDNLVI 788

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP +Y+PIIP+VLVNG  GI TGW+ +IP +NP D+I NIKR LN+ + + M+P+Y+ +K
Sbjct: 789 EPTYYVPIIPMVLVNGTDGIGTGWSTNIPNHNPLDLIKNIKRLLNNQEPEEMIPYYRNYK 848

Query: 360 GTIDKSIGG 368
           GTI K   G
Sbjct: 849 GTITKINAG 857


>M1I137_9PHYC (tr|M1I137) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CVR-1 GN=CVR-1_657R PE=3 SV=1
          Length = 1058

 Score =  381 bits (979), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 185/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPATRQVFNQSDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYKGF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMTPWYKGFTGT 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>M1HLM1_9PHYC (tr|M1HLM1) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CVA-1 GN=CVA-1_648R PE=3 SV=1
          Length = 1058

 Score =  381 bits (979), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 185/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPATRQVFNQSDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYKGF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMTPWYKGFTGT 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>M1HIH7_9PHYC (tr|M1HIH7) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CviKI GN=CviKI_628L PE=3 SV=1
          Length = 1064

 Score =  381 bits (979), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 184/368 (50%), Positives = 255/368 (69%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++
Sbjct: 480 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLKKFITPIVVAKRGKDVRE 539

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F W +D   
Sbjct: 540 --FYSLPDYEDWVKTTKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKSLMKTFTWTSDSG- 596

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  +R+  M  ++  D  D+    +   DF+ KE IL+S   + R IPS+
Sbjct: 597 ELIDRSFNKSRAEDRKEWMTAYEPGDQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSV 656

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRK+LY AFKR L T+++V +  GYVAEHSAYHH E SL  T++ +A+DYVGS
Sbjct: 657 VDGFKPSQRKVLYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEVSLQGTIVNLAQDYVGS 716

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EP
Sbjct: 717 NNINWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEP 776

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+PIIP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWY+GFKG 
Sbjct: 777 EYYVPIIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYRGFKGK 836

Query: 362 IDKSIGGM 369
           I+++  G+
Sbjct: 837 IEETSPGV 844


>Q5XLS4_9PHYC (tr|Q5XLS4) Topoisomerase II OS=Paramecium bursaria Chlorella virus
           Marburg 1 PE=3 SV=1
          Length = 1058

 Score =  381 bits (979), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 185/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPATRQVFNQSDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYKGF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMTPWYKGFTGT 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>M1HJ96_9PHYC (tr|M1HJ96) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CVM-1 GN=CVM-1_653R PE=3 SV=1
          Length = 1058

 Score =  381 bits (979), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 185/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPATRQVFNQSDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYKGF GT
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMTPWYKGFTGT 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>D8QKJ8_SCHCM (tr|D8QKJ8) DNA topoisomerase 2 OS=Schizophyllum commune (strain
           H4-8 / FGSC 9210) GN=SCHCODRAFT_17796 PE=3 SV=1
          Length = 1494

 Score =  380 bits (975), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 185/369 (50%), Positives = 250/369 (67%), Gaps = 5/369 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRI-PYFLSELITPIIRAFHCNG 59
           + S  YG++M M DQD+DGSHIKGL++NF     PSLL++ P FL E ITPI+R     G
Sbjct: 590 IASLRYGKLMIMTDQDHDGSHIKGLILNFLDHFYPSLLKLDPAFLLEFITPIVRV--TKG 647

Query: 60  IQKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
            Q+  F++ PEYE+W +   ++  W  KYYKGLG+    + +++F + E     F    +
Sbjct: 648 NQRKDFFTLPEYERWLETTPDARKWSAKYYKGLGTSKDSDARDYFSHTEKHVIPFAQTQE 707

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
            D + I++AFSK K  +R+  +   K   + ++    I   DF+ KE IL+SMA   R I
Sbjct: 708 GDRELIDLAFSKKKADDRKEWLRTCKPGTFLNHDVDEIPISDFINKELILFSMADNIRSI 767

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS+ DG KP QRKI++G FKR+L  EI+V +L+GYV+EH+AYHH E SL  T++ +A+DY
Sbjct: 768 PSVADGLKPGQRKIIWGCFKRKLKKEIKVAQLVGYVSEHAAYHHGEQSLTMTIVNLAQDY 827

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLLM NGQ+GT  QGGKDHA+ RYI+TEL+P++R LF   D  LLK   ED   
Sbjct: 828 VGSNNINLLMPNGQYGTRDQGGKDHAAARYIFTELSPLTRSLFNTADEPLLKQQKEDNQP 887

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           VEPE+Y+PIIP+VLVNG  GI TGW+ SIP YNP DI+ANI+R ++ ++  PM PW++GF
Sbjct: 888 VEPEYYMPIIPMVLVNGADGIGTGWSTSIPSYNPTDIVANIRRLMDGEEQVPMFPWWRGF 947

Query: 359 KGTIDKSIG 367
            G I KS G
Sbjct: 948 NGEI-KSTG 955


>M1I0N6_9PHYC (tr|M1I0N6) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus MO0605SPH GN=MO0605SPH_631L PE=3 SV=1
          Length = 1058

 Score =  380 bits (975), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 180/368 (48%), Positives = 254/368 (69%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M+DQD DGSHI GL++NFF+   PSLL IP FL   +TPI+ A    G + 
Sbjct: 475 SLRYGSVMIMSDQDVDGSHIAGLVLNFFHAQFPSLLEIPGFLKRFVTPIVVA--KKGTKM 532

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + FYS P++E+W     + S W+ KYYKGLG+    + K +F N+++  K   W +D+  
Sbjct: 533 VEFYSIPDFEEWKAATPDVSTWKTKYYKGLGTSDSNDAKRYFNNLKVLVKTLTW-SDDAA 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           ++I+ +F+KS+  ER+  +L FK  +  D     I  +DF+ K+ IL+S   V R IPS+
Sbjct: 592 ESIDKSFNKSRADERKTWLLDFKPGNQLDQKLTKIPVEDFINKDLILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AF+R L +EI+V +  GYV+EH+ YHH E+SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFSAFRRNLTSEIKVAQFSGYVSEHAGYHHGEASLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NINLL   GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL EDG  +EP
Sbjct: 712 NNINLLAPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEEDGDKIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P IP +LVNG +GI TG++ +IP YNPKDI+ N+KR +N++ + PM PWY+GFKGT
Sbjct: 772 EYYVPTIPFLLVNGANGIGTGFSTNIPSYNPKDIVDNVKRLINNETMLPMTPWYRGFKGT 831

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 832 IVEASPGV 839


>R4X883_9ASCO (tr|R4X883) DNA topoisomerase 2 OS=Taphrina deformans PYCC 5710
           GN=TAPDE_001558 PE=4 SV=1
          Length = 1525

 Score =  380 bits (975), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 176/360 (48%), Positives = 254/360 (70%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGL+IN+     PSLL IP FL E ITPI+R     G + +SF
Sbjct: 594 YGHLMIMTDQDHDGSHIKGLIINYLECFYPSLLSIPGFLIEFITPIVRC--TKGKEVVSF 651

Query: 66  YSYPEYEKWWKN-WGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PEYE W ++     +W+IKY+KGLG+    + K++F +++   K F    D D D I
Sbjct: 652 FTIPEYEAWKEDVQPGKEWKIKYFKGLGTSDTADAKKYFSDLDKHLKEFHTLQDGDQDLI 711

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AFSK +  +R+  + KF    Y D++   I +K+F+  E IL+SMA   R IP+++DG
Sbjct: 712 SLAFSKHRADDRKEWLRKFVPGTYMDHSMTKIPFKNFINDELILFSMADNIRSIPNVMDG 771

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRKIL+  FKR+L  EI+V +L+GYV EH+AYHH E SL+ T++ +A+ +VGS NI
Sbjct: 772 FKPGQRKILFACFKRKLKAEIKVAQLVGYVGEHTAYHHGEQSLSQTIVGLAQSFVGSNNI 831

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           N+LM NGQFGT   GGKD AS RYI+T++  I+R +F E D+ LL YLN+DG+ VEP+W+
Sbjct: 832 NILMPNGQFGTRHSGGKDAASARYIFTDIAKIARKIFVEPDSPLLNYLNDDGLMVEPQWF 891

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
            PI+P++LVNG  GI TGW+ SIP +NP D++ NI++ ++ ++++PM PWY+GF+G I++
Sbjct: 892 APILPMILVNGAQGIGTGWSTSIPNFNPADLVRNIRKLMDGEEIKPMEPWYRGFQGLIEE 951


>J9IBE1_9SPIT (tr|J9IBE1) DNA topoisomerase 2 OS=Oxytricha trifallax
           GN=OXYTRI_07785 PE=3 SV=1
          Length = 1554

 Score =  379 bits (974), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 183/367 (49%), Positives = 256/367 (69%), Gaps = 6/367 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLR-IPYFLSELITPIIRAFHCNG 59
           +++  YG +M MADQD+DGSHIKGL+INF +   PSL++  P F+ E +TPII+A   N 
Sbjct: 511 LKTLRYGSIMIMADQDHDGSHIKGLIINFIHNFWPSLIKKFPTFVKEFVTPIIKATSHNE 570

Query: 60  IQKLSFYSYPEYEKWWKNWGNSD---WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWR 116
              L F++  EYEKW +  G ++   +RIKYYKGLG+ T  E K++FQ+++  +  F ++
Sbjct: 571 C--LQFFTIAEYEKWAQLKGTNELKSYRIKYYKGLGTSTALEAKQYFQSIKKHQINFYYK 628

Query: 117 NDEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRR 176
           +D+D D I +AFSK+K  +R+  + +F  + Y D++   +CY +F+ +E I +S+A   R
Sbjct: 629 DDKDEDKILLAFSKTKADDRKNWLSQFNPNIYVDHSKNKLCYAEFVDQELIHFSIADNMR 688

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS++DG KP QRKIL+  FKR+L  EI+V +L GY+AEH+AYHH E SL  T++ MA+
Sbjct: 689 SIPSVMDGLKPGQRKILFACFKRKLKAEIKVAQLSGYIAEHTAYHHGEISLQMTIINMAQ 748

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+NLL   GQFGT + GGK+ ASPRYIYT L P +R LF E D+ LLKY  E+G
Sbjct: 749 DFVGSNNLNLLQPIGQFGTRMMGGKESASPRYIYTNLTPFARSLFNENDDPLLKYQIEEG 808

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
           + +EPE+Y+P++PLVL+NG  GI TGW+  IPC++P  II NIKR L       M PWYK
Sbjct: 809 MGIEPEFYVPVLPLVLINGAEGIGTGWSTYIPCFSPIHIIHNIKRHLEGKPFLRMQPWYK 868

Query: 357 GFKGTID 363
           GF G I+
Sbjct: 869 GFTGQIE 875


>A7IUS6_PBCVM (tr|A7IUS6) Putative uncharacterized protein M546R OS=Paramecium
           bursaria Chlorella virus MT325 GN=M546R PE=3 SV=1
          Length = 1058

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 184/367 (50%), Positives = 252/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ I GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRILGGKDCASARYIFTKLSPVTRQVFNQADDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYK F G+
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIINNVKRLISGKEMVPMTPWYKEFTGS 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>H3G7M6_PHYRM (tr|H3G7M6) DNA topoisomerase 2 (Fragment) OS=Phytophthora ramorum
           GN=gwEuk.69.30.1 PE=3 SV=1
          Length = 1174

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/359 (50%), Positives = 247/359 (68%), Gaps = 5/359 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M MADQD+DGSHIKGL+IN  +   PSLL +  FL E ITPI++     G  K  F
Sbjct: 518 YGHLMIMADQDHDGSHIKGLVINLIHHFWPSLLVVEGFLQEFITPIVKC--TKGRTKEVF 575

Query: 66  YSYPEYEKWWK--NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ PEYE W +  N G   W IKYYKGLG+ T  E KE+F +++  +  F +  D D D 
Sbjct: 576 YTMPEYESWRERTNQGRG-WVIKYYKGLGTSTAAETKEYFSDLQTHQIGFTYEGDGDADV 634

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I++AFSK +  +R+  +  ++   Y DY   ++ Y +F+ KE IL+SMA   R IPS++D
Sbjct: 635 IDMAFSKKRVEDRKDWLRGYEPGTYVDYDVDAMGYTEFVNKELILFSMADNIRSIPSILD 694

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KPSQRK+L+  FKR L +E++V +L GYV+EHSAYHH E SL   ++ MA+D+VGS N
Sbjct: 695 GFKPSQRKVLFCCFKRNLRSELKVAQLAGYVSEHSAYHHGEQSLQGCIVNMAQDFVGSNN 754

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           I+LL   GQFGT + GGKD AS RYI+T L  ++R ++  +DN +LKYL+EDG S+EPEW
Sbjct: 755 IHLLSPIGQFGTRLMGGKDSASARYIFTNLEQLTRLIYDPLDNDVLKYLDEDGQSIEPEW 814

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           Y+PIIP+VLVNG  GI TGW+ S+P YNP DII  +++ +N ++  P+ PWY+GF G I
Sbjct: 815 YIPIIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEATPLTPWYRGFTGHI 873


>M1IG07_9PHYC (tr|M1IG07) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus NE-JV-4 GN=NE-JV-4_671L PE=3 SV=1
          Length = 1064

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/368 (49%), Positives = 255/368 (69%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++
Sbjct: 480 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLKKFITPIVVAKKGKDVRE 539

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F W +D   
Sbjct: 540 --FYSLPDYEDWVKTTKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKSLMKTFTWTSDSG- 596

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+K++  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS+
Sbjct: 597 ELIDRSFNKTRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSV 656

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRK+LY AFKR L T+++V +  GYVAEHSAYHH E SL  T++ +A+DYVGS
Sbjct: 657 VDGFKPSQRKVLYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEVSLQGTIVNLAQDYVGS 716

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EP
Sbjct: 717 NNINWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEP 776

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+PIIP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWY+GFKG 
Sbjct: 777 EYYVPIIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYRGFKGK 836

Query: 362 IDKSIGGM 369
           I+++  G+
Sbjct: 837 IEETFPGV 844


>M1HEE6_9PHYC (tr|M1HEE6) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus AN69C GN=AN69C_513R PE=3 SV=1
          Length = 1064

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/368 (49%), Positives = 255/368 (69%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++
Sbjct: 480 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLKKFITPIVVAKKGKDVRE 539

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F W +D   
Sbjct: 540 --FYSLPDYEDWVKTTKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKSLMKTFTWTSDSG- 596

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+K++  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS+
Sbjct: 597 ELIDRSFNKTRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSV 656

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRK+LY AFKR L T+++V +  GYVAEHSAYHH E SL  T++ +A+DYVGS
Sbjct: 657 VDGFKPSQRKVLYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEVSLQGTIVNLAQDYVGS 716

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EP
Sbjct: 717 NNINWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEP 776

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+PIIP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWY+GFKG 
Sbjct: 777 EYYVPIIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYRGFKGK 836

Query: 362 IDKSIGGM 369
           I+++  G+
Sbjct: 837 IEETFPGV 844


>F4PXP4_DICFS (tr|F4PXP4) DNA topoisomerase 2 OS=Dictyostelium fasciculatum (strain
            SH3) GN=top2 PE=3 SV=1
          Length = 1574

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 184/364 (50%), Positives = 256/364 (70%), Gaps = 3/364 (0%)

Query: 1    MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
            + +  YG +M M DQD+DGSHIKGL++NF +   PSLL+I  FL E ITPII+AF     
Sbjct: 639  ISTLRYGHLMIMTDQDHDGSHIKGLILNFIHHFWPSLLKIDGFLMEFITPIIKAFKGKN- 697

Query: 61   QKLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
            + +SFY+ PEY KW +  G   + IKYYKGLG+   EEGKE+F ++E  +  F W ++ D
Sbjct: 698  KPISFYTIPEYLKWKETNGGKGYEIKYYKGLGTSKAEEGKEYFADIERHKLDFQWDDNAD 757

Query: 121  LDAINIAFSKSKTRERRGLMLKFKSSDYRD-YTDLSICYKDFLQKEFILYSMASVRRCIP 179
             D+I++AF+K +  +R+  +  F+   Y D Y    I   +F+ KE IL+S+A   R IP
Sbjct: 758  -DSIDMAFNKKRADDRKKWLNDFEPGTYLDQYGAKKIKISEFINKELILFSIADCERSIP 816

Query: 180  SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            S++DG K SQRKILY  FKR L  E+RV +LIGYV+EHSAYHH E+SLA+T++ MA+DYV
Sbjct: 817  SIVDGLKISQRKILYSCFKRNLKKELRVAQLIGYVSEHSAYHHGEASLASTIINMAQDYV 876

Query: 240  GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
            GS NIN L  +G FG+ +QGGKD + PRYI+T L  I+R LF + D+ LL Y+N+DG  V
Sbjct: 877  GSNNINTLYPSGSFGSRLQGGKDSSQPRYIHTCLRDITRTLFHQDDDNLLTYVNDDGKKV 936

Query: 300  EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
            +P+WY+P IP VLVNG SGI TG++ SIP YNP+D+I  ++  L++ ++  + PWY+GF+
Sbjct: 937  QPKWYMPTIPFVLVNGSSGIGTGYSSSIPNYNPRDLIQCMRDLLDEKEMTDIKPWYRGFR 996

Query: 360  GTID 363
            G+I+
Sbjct: 997  GSIE 1000


>G3B4R2_CANTC (tr|G3B4R2) DNA topoisomerase 2 OS=Candida tenuis (strain ATCC
           10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
           NRRL Y-1498 / VKM Y-70) GN=CANTEDRAFT_104632 PE=3 SV=1
          Length = 1429

 Score =  379 bits (972), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/362 (50%), Positives = 248/362 (68%), Gaps = 4/362 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIR-AFHCNGIQK-- 62
           YG +M M DQD DGSHIKGL+INF     P LL IP FL E ITPI++      G  K  
Sbjct: 565 YGHIMIMTDQDQDGSHIKGLIINFLESSFPGLLEIPGFLLEFITPIVKVTVSQRGSSKKV 624

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           LSFY+ PE+E W +  G    W+ KYYKGLG+ T  E +E+F  ++   K F     ED 
Sbjct: 625 LSFYTMPEFENWRETEGTRCRWKQKYYKGLGTSTDVEAREYFAALDKHLKQFHAIQGEDP 684

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           D I++AFSK K  ER+  + +F+   + D     I   DF+ KE IL+SMA   R IPS+
Sbjct: 685 DLIDLAFSKKKADERKNWLQEFQPGTHLDPELKIIPISDFINKELILFSMADNVRSIPSV 744

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KP QRK+L+G FKR L +EI+V +L GYV+EH+ YHH E SL  T++ +A++++GS
Sbjct: 745 LDGFKPGQRKVLFGCFKRNLKSEIKVAQLAGYVSEHTGYHHGEQSLIQTIIGLAQNFIGS 804

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL  NG FGT   GGKD ++ RYI+TE+N I+R +F  +DN LL Y+ ED  +VEP
Sbjct: 805 NNLNLLKPNGAFGTRAAGGKDFSAARYIFTEINEITRKIFNPLDNGLLTYVQEDEQTVEP 864

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWYLPIIP++LVNG  GI TGW+ +IPCYNP+DI+ANI++ +N+++L+ M PWY+G++G 
Sbjct: 865 EWYLPIIPMILVNGAEGIGTGWSTNIPCYNPEDIVANIRKLMNNEELEEMFPWYRGWEGD 924

Query: 362 ID 363
           ++
Sbjct: 925 LE 926


>M1HR94_9PHYC (tr|M1HR94) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CvsA1 GN=CvsA1_650L PE=3 SV=1
          Length = 1064

 Score =  379 bits (972), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/368 (49%), Positives = 255/368 (69%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++
Sbjct: 480 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLKKFITPIVVAKRGKDVRE 539

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F W +D   
Sbjct: 540 --FYSLPDYEDWVKTTKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKSLMKTFTWTSDSG- 596

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+K++  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS+
Sbjct: 597 ELIDRSFNKTRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSV 656

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRK+LY AFKR L T+++V +  GYVAEHSAYHH E SL  T++ +A+DYVGS
Sbjct: 657 VDGFKPSQRKVLYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEVSLQGTIVNLAQDYVGS 716

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EP
Sbjct: 717 NNINWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEP 776

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+PIIP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWY+GFKG 
Sbjct: 777 EYYVPIIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYRGFKGK 836

Query: 362 IDKSIGGM 369
           I+++  G+
Sbjct: 837 IEETSPGV 844


>F1KQV5_ASCSU (tr|F1KQV5) DNA topoisomerase 2 OS=Ascaris suum PE=2 SV=1
          Length = 1586

 Score =  378 bits (971), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 185/377 (49%), Positives = 256/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG+VM MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 582 MKTLRYGKVMVMADQDQDGSHIKGLVINFIHYNWPALIR-RNFVEEFITPIVKA--TKGK 638

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++ SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  DE
Sbjct: 639 EEYSFFSLPEYNEWRNNTENWKSYRIKYYKGLGTSTSKEAKEYFTDMARHRIRFRYAGDE 698

Query: 120 DLDAINIAFSKSKTRERRGLMLKF--KSSDYR----------DYTDLSICYKDFLQKEFI 167
           D  +I++AFSK K  +R+  +  +  +  D R          D    SI +KDF+ KE +
Sbjct: 699 DDSSIDMAFSKRKIEDRKVWLTNWMAEKRDRREQGLTEEYLYDKDTRSISFKDFVNKELV 758

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S A   R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E SL
Sbjct: 759 LFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEQSL 818

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP +D+ 
Sbjct: 819 MSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSVDDN 878

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  +P YNP++I+ NI+R +  + 
Sbjct: 879 VLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKVPNYNPREIVDNIRRLIRGED 938

Query: 348 LQPMVPWYKGFKGTIDK 364
            +PMVPW+K F+GTI++
Sbjct: 939 PKPMVPWFKNFRGTIEQ 955


>F2U845_SALS5 (tr|F2U845) DNA topoisomerase 2 OS=Salpingoeca sp. (strain ATCC
           50818) GN=PTSG_04681 PE=3 SV=1
          Length = 1761

 Score =  378 bits (971), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 179/358 (50%), Positives = 246/358 (68%), Gaps = 3/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YGR+M M DQD DGSHIKGLLINF +   PSLL++P FL E +TPI++     G Q++SF
Sbjct: 529 YGRLMIMTDQDQDGSHIKGLLINFIHHFWPSLLKMPDFLVEFVTPIVKC--TKGKQEVSF 586

Query: 66  YSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ P+YE W +  GN   WRIKYYKGLG+ T +E KE+F +++  +  F +  D+D + I
Sbjct: 587 FTIPQYETWAEQQGNLKGWRIKYYKGLGTSTPQEAKEYFSHMDDHQIPFSYEGDKDFEDI 646

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
            +AFSK     R+  +  F    Y D+   +ICY DF+ KE IL+SMA   R IPS++DG
Sbjct: 647 VMAFSKKHVEARKQWLKNFVPGTYLDHATDAICYSDFINKELILFSMADNVRSIPSIMDG 706

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+L+  FKR+L  EI+V +L GYV+EHSAYHH E SLA T++ MA+ +VGS N+
Sbjct: 707 LKPGQRKVLFSCFKRKLKDEIKVAQLAGYVSEHSAYHHGEMSLAGTIVGMAQRFVGSNNL 766

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLL+  GQFGT + GGKD AS RYI+T L+P++R +F   D+ LL +L +DG ++EPE+Y
Sbjct: 767 NLLLPIGQFGTRLAGGKDAASSRYIFTSLSPLARKIFHLADDALLNHLEDDGQTIEPEFY 826

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
            PI+P+VLVNG  GI TGW+ S+P YNP+D++  +   +   +   + PWY GF G I
Sbjct: 827 APILPMVLVNGSDGIGTGWSSSVPNYNPRDLVNALIAMIEGQEPDELHPWYAGFTGEI 884


>G0T007_RHOG2 (tr|G0T007) DNA topoisomerase 2 OS=Rhodotorula glutinis (strain ATCC
            204091 / IIP 30 / MTCC 1151) GN=RTG_02278 PE=3 SV=1
          Length = 1591

 Score =  378 bits (971), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 180/364 (49%), Positives = 255/364 (70%), Gaps = 3/364 (0%)

Query: 2    ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
            +S  YG +M MADQD+DGSHIKGL+INF     PSLL++P FL E ITPI++     G +
Sbjct: 672  DSLRYGSLMIMADQDHDGSHIKGLIINFLDYWFPSLLKLPNFLVEFITPIVKV--SKGKK 729

Query: 62   KLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
            ++SF++ PEYE W     +   W+IKY+KGLG+    + K++F ++   R  F     ED
Sbjct: 730  EISFFTIPEYEAWKAETDDGRGWKIKYFKGLGTSDTNDAKKYFSDMNRHRLPFKELTPED 789

Query: 121  LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
               I++AF+K K  +R+  +  F    Y D+    +  KDF+ KE IL+SMA   R IPS
Sbjct: 790  RALIDMAFNKKKADDRKEWLRGFVPGTYMDHDVDEVPIKDFINKELILFSMADNIRSIPS 849

Query: 181  LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
            ++DG KP QRK+L+G FKR+L  EI+V +L GY++EHSAYHH ++SL  T++ +A+++VG
Sbjct: 850  VVDGFKPGQRKVLFGCFKRKLKNEIKVGQLSGYISEHSAYHHGDASLQGTIVGLAQNFVG 909

Query: 241  SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
            S NIN+L  NGQFGT +QGGKD AS RYI+T +  I+R LF   D+ +L YLN+DG S+E
Sbjct: 910  SNNINVLDPNGQFGTRLQGGKDAASARYIFTNVAQITRTLFHPSDDAILDYLNDDGQSIE 969

Query: 301  PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
            P WY+PI+P+VLVNG  GI TGW+  IP +NP DI+AN++R L+ ++++P+ PWY+GF+G
Sbjct: 970  PSWYIPILPMVLVNGSDGIGTGWSSFIPNFNPSDIVANLRRKLDGEEMEPIHPWYRGFRG 1029

Query: 361  TIDK 364
            TI+K
Sbjct: 1030 TIEK 1033


>F2U844_SALS5 (tr|F2U844) DNA topoisomerase 2 OS=Salpingoeca sp. (strain ATCC
           50818) GN=PTSG_04681 PE=3 SV=1
          Length = 1795

 Score =  378 bits (971), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 179/358 (50%), Positives = 246/358 (68%), Gaps = 3/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YGR+M M DQD DGSHIKGLLINF +   PSLL++P FL E +TPI++     G Q++SF
Sbjct: 563 YGRLMIMTDQDQDGSHIKGLLINFIHHFWPSLLKMPDFLVEFVTPIVKC--TKGKQEVSF 620

Query: 66  YSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ P+YE W +  GN   WRIKYYKGLG+ T +E KE+F +++  +  F +  D+D + I
Sbjct: 621 FTIPQYETWAEQQGNLKGWRIKYYKGLGTSTPQEAKEYFSHMDDHQIPFSYEGDKDFEDI 680

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
            +AFSK     R+  +  F    Y D+   +ICY DF+ KE IL+SMA   R IPS++DG
Sbjct: 681 VMAFSKKHVEARKQWLKNFVPGTYLDHATDAICYSDFINKELILFSMADNVRSIPSIMDG 740

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRK+L+  FKR+L  EI+V +L GYV+EHSAYHH E SLA T++ MA+ +VGS N+
Sbjct: 741 LKPGQRKVLFSCFKRKLKDEIKVAQLAGYVSEHSAYHHGEMSLAGTIVGMAQRFVGSNNL 800

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLL+  GQFGT + GGKD AS RYI+T L+P++R +F   D+ LL +L +DG ++EPE+Y
Sbjct: 801 NLLLPIGQFGTRLAGGKDAASSRYIFTSLSPLARKIFHLADDALLNHLEDDGQTIEPEFY 860

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
            PI+P+VLVNG  GI TGW+ S+P YNP+D++  +   +   +   + PWY GF G I
Sbjct: 861 APILPMVLVNGSDGIGTGWSSSVPNYNPRDLVNALIAMIEGQEPDELHPWYAGFTGEI 918


>F1KQU1_ASCSU (tr|F1KQU1) DNA topoisomerase 2 OS=Ascaris suum PE=2 SV=1
          Length = 1388

 Score =  378 bits (970), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 185/377 (49%), Positives = 256/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG+VM MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 582 MKTLRYGKVMVMADQDQDGSHIKGLVINFIHYNWPALIR-RNFVEEFITPIVKA--TKGK 638

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++ SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  DE
Sbjct: 639 EEYSFFSLPEYNEWRNNTENWKSYRIKYYKGLGTSTSKEAKEYFTDMARHRIRFRYAGDE 698

Query: 120 DLDAINIAFSKSKTRERRGLMLKF--KSSDYR----------DYTDLSICYKDFLQKEFI 167
           D  +I++AFSK K  +R+  +  +  +  D R          D    SI +KDF+ KE +
Sbjct: 699 DDSSIDMAFSKRKIEDRKVWLTNWMAEKRDRREQGLTEEYLYDKDTRSISFKDFVNKELV 758

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S A   R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E SL
Sbjct: 759 LFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEQSL 818

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP +D+ 
Sbjct: 819 MSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSVDDN 878

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  +P YNP++I+ NI+R +  + 
Sbjct: 879 VLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKVPNYNPREIVDNIRRLIRGED 938

Query: 348 LQPMVPWYKGFKGTIDK 364
            +PMVPW+K F+GTI++
Sbjct: 939 PKPMVPWFKNFRGTIEQ 955


>K6UXA3_9APIC (tr|K6UXA3) DNA topoisomerase 2 OS=Plasmodium cynomolgi strain B
           GN=PCYB_132540 PE=3 SV=1
          Length = 1506

 Score =  378 bits (970), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 181/358 (50%), Positives = 249/358 (69%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FLSE +TPI++    N  Q+ SF
Sbjct: 584 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQKGN--QEYSF 641

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W ++     W+IKYYKGLG+ T +E KE+F +++  +  F+W  D D D+I+
Sbjct: 642 FTIAEYEQWKESTNLVGWKIKYYKGLGTSTDKEFKEYFSDIKNHKIMFLWTGDRDGDSID 701

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 702 MAFSKKRIEDRKLWLQNFIIGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 761

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 762 KPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 821

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R LF E D+ +LKYLNE+G  +EP++Y+
Sbjct: 822 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSLFNEYDDPILKYLNEEGQKIEPQYYI 881

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIKR++N ++L PM+PWYK FKG I+
Sbjct: 882 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIIENIKRYINKEELIPMIPWYKDFKGRIE 939


>M7WCM6_RHOTO (tr|M7WCM6) DNA topoisomerase II OS=Rhodosporidium toruloides NP11
            GN=RHTO_06677 PE=4 SV=1
          Length = 1562

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 180/364 (49%), Positives = 255/364 (70%), Gaps = 3/364 (0%)

Query: 2    ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
            +S  YG +M MADQD+DGSHIKGL+INF     PSLL++P FL E ITPI++     G +
Sbjct: 650  DSLRYGSLMIMADQDHDGSHIKGLIINFLDYWFPSLLKLPNFLVEFITPIVKV--SKGKK 707

Query: 62   KLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
            ++SF++ PEYE W     +   W+IKY+KGLG+    + K++F ++   R  F     ED
Sbjct: 708  EISFFTIPEYEAWKAETDDGRGWKIKYFKGLGTSDTNDAKKYFGDMNRHRLPFKELTPED 767

Query: 121  LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
               I++AF+K K  +R+  +  F    Y D+    +  KDF+ KE IL+SMA   R IPS
Sbjct: 768  RALIDMAFNKKKADDRKEWLRGFVPGTYMDHDVDEVPIKDFINKELILFSMADNIRSIPS 827

Query: 181  LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
            ++DG KP QRK+L+G FKR+L  EI+V +L GY++EHSAYHH ++SL  T++ +A+++VG
Sbjct: 828  VVDGFKPGQRKVLFGCFKRKLKNEIKVGQLSGYISEHSAYHHGDASLQGTIVGLAQNFVG 887

Query: 241  SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
            S NIN+L  NGQFGT +QGGKD AS RYI+T +  I+R LF   D+ +L YLN+DG S+E
Sbjct: 888  SNNINVLDPNGQFGTRLQGGKDAASARYIFTNVAQITRTLFHPSDDAILDYLNDDGQSIE 947

Query: 301  PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
            P WY+PI+P+VLVNG  GI TGW+  IP +NP DI+AN++R L+ ++++P+ PWY+GF+G
Sbjct: 948  PSWYIPILPMVLVNGSDGIGTGWSSFIPNFNPSDIVANLRRKLDGEEMEPIHPWYRGFRG 1007

Query: 361  TIDK 364
            TI+K
Sbjct: 1008 TIEK 1011


>D0NA12_PHYIT (tr|D0NA12) DNA topoisomerase 2 OS=Phytophthora infestans (strain
           T30-4) GN=PITG_07874 PE=3 SV=1
          Length = 1505

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/359 (50%), Positives = 246/359 (68%), Gaps = 5/359 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M MADQD+DGSHIKGL+IN  +   PSLL +  FL E ITPI++     G  K  F
Sbjct: 592 YGHLMIMADQDHDGSHIKGLVINLIHHFWPSLLVVDGFLQEFITPIVKC--TKGRTKEVF 649

Query: 66  YSYPEYEKWWK--NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ PEYE W +  N G   W IKYYKGLG+ T  E KE+F +++  +  F +  D D D 
Sbjct: 650 YTMPEYEAWRERTNQGRG-WVIKYYKGLGTSTAAETKEYFSDLQTHQIGFTYDGDGDADV 708

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I++AFSK +  +R+  +  ++   Y DY    + Y +F+ KE IL+SMA   R IPS++D
Sbjct: 709 IDMAFSKKRVEDRKDWLRGYEPGTYVDYDVDEMGYTEFVNKELILFSMADNIRSIPSVMD 768

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KPSQRK+L+  FKR L  E++V +L GYV+EHSAYHH E+SL   ++ MA+D+VGS N
Sbjct: 769 GFKPSQRKVLFCCFKRNLRAELKVAQLAGYVSEHSAYHHGEASLQGCIVNMAQDFVGSNN 828

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           I+LL   GQFGT + GGKD AS RYI+T L  ++R ++  +DN  LKYL+EDG S+EPEW
Sbjct: 829 IHLLSPIGQFGTRLMGGKDAASARYIFTNLEQLTRLIYHPLDNDCLKYLSEDGQSIEPEW 888

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           Y+PIIP+VLVNG  GI TGW+ S+P YNP DII  +++ +N +++ P+ PWY+GF G I
Sbjct: 889 YIPIIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEIAPLTPWYRGFTGHI 947


>M5E815_MALSM (tr|M5E815) Genomic scaffold, msy_sf_6 OS=Malassezia sympodialis
           ATCC 42132 GN=MSY001_1414 PE=4 SV=1
          Length = 1333

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 180/366 (49%), Positives = 250/366 (68%), Gaps = 3/366 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++   YG +M M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPII+A    G 
Sbjct: 525 VDGLRYGSLMIMTDQDFDGSHIKGLIINFLDHFYPSLLKIPNFLVEFITPIIKA--TKGR 582

Query: 61  QKLSFYSYPEYEKWWKNW-GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +  +F++ PEYE+W  +  G   W +KYYKGLG+   EE K++F +++     F      
Sbjct: 583 EVKAFFTMPEYEQWKNSSDGGRGWTVKYYKGLGTSKPEEMKKYFHDMDTHLLAFETLRPG 642

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D +++AF+K K  +R+  + +F    Y D+    I   DF+ KE IL+SMA   R IP
Sbjct: 643 DRDLVDLAFNKKKADDRKEWLRQFVPGTYLDHRIRQIPISDFINKELILFSMADNIRSIP 702

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRK+L+G FKR L TEI+V +L GYV+EH+AYHH + SL  T++ +A+D+ 
Sbjct: 703 SVVDGLKPGQRKVLFGCFKRNLKTEIKVQQLQGYVSEHTAYHHGDQSLVMTIVGLAQDFC 762

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS N+N+LM NGQFGT   GGKD AS RYI+T +  I+R LF   D+ LL YL+EDG S+
Sbjct: 763 GSNNVNMLMPNGQFGTRSMGGKDAASARYIFTAVPRITRQLFHPKDDALLNYLDEDGQSI 822

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPEWY+P++P VL+NG  GI TGW+  +P YNP+DI+AN++R +  ++  PM+PWY+GF 
Sbjct: 823 EPEWYVPVVPQVLLNGADGIGTGWSTFVPNYNPRDIVANLRRRMVGEEYVPMIPWYRGFA 882

Query: 360 GTIDKS 365
           GTI+ +
Sbjct: 883 GTIEPT 888


>M1HT83_9PHYC (tr|M1HT83) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus MA-1D GN=MA-1D_804L PE=3 SV=1
          Length = 1062

 Score =  377 bits (968), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 181/368 (49%), Positives = 256/368 (69%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++
Sbjct: 481 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLKKFITPIVVAKKGKDVRE 540

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F+W +D   
Sbjct: 541 --FYSLPDYEDWVKTTKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKSLMKTFMWTSDSG- 597

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS+
Sbjct: 598 ELIDRSFNKSRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSV 657

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRK+LY AFKR L T+++V +  GYVAEHSAYHH E+SL  T++ +A+DYVGS
Sbjct: 658 VDGFKPSQRKVLYCAFKRNLTTDVKVAQFSGYVAEHSAYHHGEASLQGTIVNLAQDYVGS 717

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EP
Sbjct: 718 NNINWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEP 777

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P+IP +LVNG SGI TGW+ +IP YNPKDI+ N+KR +  + L  M PW++GFKG 
Sbjct: 778 EYYVPVIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLIAGEDLVEMKPWFRGFKGK 837

Query: 362 IDKSIGGM 369
           I+++  G+
Sbjct: 838 IEETSPGV 845


>M1I7C8_9PHYC (tr|M1I7C8) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus WI0606 GN=WI0606_657L PE=3 SV=1
          Length = 1056

 Score =  377 bits (968), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 180/367 (49%), Positives = 250/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI GL++NFF+   PSLL IP FL +  TPI+ A     +++
Sbjct: 475 SLRYGSVMLMTDADVDGSHIAGLVLNFFHAQFPSLLEIPGFLKKFTTPIVIAKRGKDMKE 534

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             FYS P++E W K  G+  W +KY KGLG+ T E+ K +F+N++   K F W +D   +
Sbjct: 535 --FYSLPDFEDWKKTSGDK-WSVKYLKGLGTSTSEDAKRYFKNLKGLTKVFGWTDDSS-E 590

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  ER+  +L F+  +  D T   I   DF+ KE IL+S   V R +PS++
Sbjct: 591 LIDRSFNKSRADERKTWLLNFEPGNQLDQTLTKIPVDDFIDKELILFSRYDVERSVPSVV 650

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRKIL+ AFKR L +EI+V +  GYV+EH+ YHH E+SL   ++ MA+DYVGS 
Sbjct: 651 DGLKPSQRKILFSAFKRNLTSEIKVAQFAGYVSEHAGYHHGEASLQGAIVAMAQDYVGSN 710

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLLM  GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EPE
Sbjct: 711 NINLLMPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDKIEPE 770

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P IP++LVNG +GI TG++ +IP YNPKDI+ N+KR +N   +  M PWY+GFKG I
Sbjct: 771 YYVPTIPMILVNGANGIGTGFSTNIPSYNPKDIVDNVKRLINGKAMTEMTPWYRGFKGDI 830

Query: 363 DKSIGGM 369
            ++  G+
Sbjct: 831 KETSPGV 837


>D7G0Y6_ECTSI (tr|D7G0Y6) DNA topoisomerase 2 OS=Ectocarpus siliculosus GN=TOP2
           PE=3 SV=1
          Length = 1809

 Score =  377 bits (967), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 184/364 (50%), Positives = 249/364 (68%), Gaps = 4/364 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLINF +   PSLL+I  FL E ITPI++     G  +LSF
Sbjct: 540 YGHLMIMTDQDHDGSHIKGLLINFVHHYWPSLLKIDGFLQEFITPIVKV--SKGRNELSF 597

Query: 66  YSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           Y+ PEY  W +   N   W  KYYKGLG+ T +E KE+F  ++  +  F W++D+  D +
Sbjct: 598 YTVPEYTVWKEGHANGKGWNAKYYKGLGTSTAKEAKEYFAALDTHQLEFEWQDDDRDDDL 657

Query: 125 N-IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
             +AFSK +  +R+  +  FK+  + DY   S+ Y+ F+ KE IL+SM   +R IP L+D
Sbjct: 658 IDMAFSKKRVEDRKEWLRGFKAGTHADYNVESVTYESFINKELILFSMEDNKRSIPCLVD 717

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KPSQRK+L+  FKR L  EI+V +L GYV+EHSAYHH E+SL  T+  MA+++ GS N
Sbjct: 718 GFKPSQRKVLFSCFKRNLKKEIKVVQLAGYVSEHSAYHHGETSLNGTITAMAQNFTGSNN 777

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           +NLL   GQFGT + GGKD ASPRYI+T L   +R +F   D+ LL YL++DG+S+EPE+
Sbjct: 778 LNLLTPGGQFGTRLMGGKDAASPRYIFTALQKAARAVFHPDDDALLTYLDDDGLSIEPEF 837

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PIIPL+LVNG  GI TGW+ ++P Y+P D+I N+KR +  DK   M PWYKGF G+I+
Sbjct: 838 YMPIIPLILVNGSDGIGTGWSSNVPNYSPHDVIENLKRRIKGDKFVEMQPWYKGFAGSIE 897

Query: 364 KSIG 367
             +G
Sbjct: 898 AKVG 901


>Q7RJ69_PLAYO (tr|Q7RJ69) DNA topoisomerase 2 OS=Plasmodium yoelii yoelii
           GN=PY03394 PE=3 SV=1
          Length = 1489

 Score =  377 bits (967), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 179/358 (50%), Positives = 249/358 (69%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FL E +TPI++    N  Q+LSF
Sbjct: 575 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLCEFVTPIVKVQKGN--QELSF 632

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W +N     W+IKYYKGLG+ T +E K++F +++  + +F+W  D D D+I+
Sbjct: 633 FTIAEYEQWKENTNLVGWKIKYYKGLGTSTDKEFKQYFSDIQSHKIFFLWTGDRDGDSID 692

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 693 MAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 752

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 753 KPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 812

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 813 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYI 872

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIK++++ + L PMVPWYK FKG I+
Sbjct: 873 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIINNIKKYIDKEPLVPMVPWYKDFKGRIE 930


>M1I5G7_9PHYC (tr|M1I5G7) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus NTS-1 GN=NTS-1_688L PE=3 SV=1
          Length = 1066

 Score =  377 bits (967), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 180/367 (49%), Positives = 250/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI GL++NFF+   PSLL IP FL +  TPI+ A     +++
Sbjct: 485 SLRYGSVMLMTDADVDGSHIAGLVLNFFHAQFPSLLEIPGFLKKFTTPIVIAKRGKDMKE 544

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             FYS P++E W K  G+  W +KY KGLG+ T E+ K +F+N++   K F W +D   +
Sbjct: 545 --FYSLPDFEDWKKTSGDK-WSVKYLKGLGTSTSEDAKRYFKNLKGLTKVFGWTDDSS-E 600

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  ER+  +L F+  +  D T   I   DF+ KE IL+S   V R +PS++
Sbjct: 601 LIDRSFNKSRADERKTWLLNFEPGNQLDQTLTKIPVDDFIDKELILFSRYDVERSVPSVV 660

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRKIL+ AFKR L +EI+V +  GYV+EH+ YHH E+SL   ++ MA+DYVGS 
Sbjct: 661 DGLKPSQRKILFSAFKRNLTSEIKVAQFAGYVSEHAGYHHGEASLQGAIVAMAQDYVGSN 720

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLLM  GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EPE
Sbjct: 721 NINLLMPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDKIEPE 780

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P IP++LVNG +GI TG++ +IP YNPKDI+ N+KR +N   +  M PWY+GFKG I
Sbjct: 781 YYVPTIPMILVNGANGIGTGFSTNIPSYNPKDIVDNVKRLINGKAMTEMTPWYRGFKGDI 840

Query: 363 DKSIGGM 369
            ++  G+
Sbjct: 841 KETSPGV 847


>G0QS48_ICHMG (tr|G0QS48) DNA topoisomerase 2 OS=Ichthyophthirius multifiliis
           (strain G5) GN=IMG5_099230 PE=3 SV=1
          Length = 1481

 Score =  377 bits (967), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/370 (49%), Positives = 253/370 (68%), Gaps = 4/370 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +  MADQD+DGSHIKGL INF     PSL  +  FL E +TPI++     G Q
Sbjct: 505 KSLRYGSIAIMADQDHDGSHIKGLFINFIQNFWPSLFEMKGFLKEFVTPIVKVRK--GEQ 562

Query: 62  KLSFYSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            LSF+S  +++KW  + G++   W+ KYYKGLG+ T  E +E+FQNVE     F + NDE
Sbjct: 563 SLSFFSLHDFKKWKNSLGDNSNQWKTKYYKGLGTSTDMEAREYFQNVEKHMISFTYLNDE 622

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D ++I++AF+K K   R+  +  F   D  D+T  ++ YKDF+ KE I +S++   R IP
Sbjct: 623 DEESIDLAFNKKKADARKEWLNAFNEDDNVDHTQKNLRYKDFVHKELINFSISDNARSIP 682

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           ++ DG K  QRKIL+  FKR L  EI+V +L GYVAEHSAYHH E SLA T+  MA+++V
Sbjct: 683 NICDGLKTGQRKILFACFKRNLKQEIKVAQLSGYVAEHSAYHHGEQSLAQTITGMAQNFV 742

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLLM  GQFG+   GGK+ AS RYI+T LN I+R +FP+ D+ +L+YL +DG  V
Sbjct: 743 GSNNINLLMPIGQFGSRNMGGKEAASARYIHTNLNKITRVIFPQNDDYILQYLEDDGYLV 802

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP++YLPIIP+VLVNG  GI TGW+ SIP YNP++I+ +I++ +  +  + ++PWYKG++
Sbjct: 803 EPKYYLPIIPMVLVNGAEGIGTGWSTSIPQYNPREIVQSIQKRMEGENWEQLIPWYKGYQ 862

Query: 360 GTIDKSIGGM 369
           G I+ +  G 
Sbjct: 863 GEIENNDKGQ 872


>M1HFA5_9PHYC (tr|M1HFA5) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus AP110A GN=AP110A_649R PE=3 SV=1
          Length = 1058

 Score =  377 bits (967), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 183/367 (49%), Positives = 251/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPATRQVFNQSDDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYK F G+
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMTPWYKEFTGS 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>H8ZD93_NEMS1 (tr|H8ZD93) DNA topoisomerase 2 OS=Nematocida sp. 1 (strain ERTm2 /
           ATCC PRA-371) GN=NERG_01564 PE=3 SV=1
          Length = 1186

 Score =  376 bits (966), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 184/364 (50%), Positives = 244/364 (67%), Gaps = 4/364 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           ES  YG +M M DQD+DGSHIKGL+IN      PSLLRI  FL E ITPI+RA    G  
Sbjct: 495 ESLRYGHIMIMTDQDHDGSHIKGLIINMIDHFFPSLLRIKGFLQEFITPIVRA--TKGSM 552

Query: 62  KLSFYSYPEYEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
              F++ PE+E W +     +  WR+KYYKGLG+ T ++ K++F N++   K F   +  
Sbjct: 553 SRDFFTIPEFESWTETAEGRENGWRVKYYKGLGTSTAKDAKDYFSNLDFHIKEFNTVDSV 612

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D I +AFSK +   R+  + +F    Y D    +I  K+F+ +E I +S+A   R IP
Sbjct: 613 DRDKIELAFSKKRVESRKVWLKEFVPGTYLDNRVQAISIKNFIDRELIHFSLADNIRSIP 672

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           ++IDG KP QRKI++  FKR+L TEI+V +L GYV+EHSAYHH E SL +T++ +A+DYV
Sbjct: 673 NMIDGMKPGQRKIIFCCFKRQLRTEIKVAQLAGYVSEHSAYHHGEQSLCSTIVNLAQDYV 732

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NI LL   GQFGT +QGGKD ASPRYI+T L PI+R+LF E D+ LL YL +D + V
Sbjct: 733 GSNNIPLLQPIGQFGTRLQGGKDAASPRYIFTALQPITRYLFREEDDNLLNYLKDDNLMV 792

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP+ Y+PIIP+VLVNG  GI TGW+  IP YNP +I+ N+KR +   + + M+PWYKGF 
Sbjct: 793 EPDMYVPIIPMVLVNGSDGIGTGWSTCIPPYNPIEIVDNVKRMIMGKEPKEMIPWYKGFV 852

Query: 360 GTID 363
           G  D
Sbjct: 853 GECD 856


>Q7Z2D0_PLAFA (tr|Q7Z2D0) DNA topoisomerase 2 OS=Plasmodium falciparum GN=TopoII
           PE=3 SV=1
          Length = 1397

 Score =  376 bits (966), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 181/358 (50%), Positives = 247/358 (68%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FLSE +TPI++     G Q+ SF
Sbjct: 569 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKV--QKGSQEYSF 626

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W +N     W+IKYYKGLG+ T  E K++F +++  +  F+W  D D D+I+
Sbjct: 627 FTIAEYEQWKENTNLLGWKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGDRDGDSID 686

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 687 MAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 746

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 747 KPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 806

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 807 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYI 866

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIKR++N + L PMVPWYK FKG I+
Sbjct: 867 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDFKGRIE 924


>G7DZ82_MIXOS (tr|G7DZ82) DNA topoisomerase 2 OS=Mixia osmundae (strain CBS 9802
           / IAM 14324 / JCM 22182 / KY 12970) GN=Mo02550 PE=3 SV=1
          Length = 1497

 Score =  376 bits (966), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 184/364 (50%), Positives = 250/364 (68%), Gaps = 4/364 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGL+INF     PSLLRIP FL E ITPI++       
Sbjct: 615 VDSLRYGHLMIMTDQDHDGSHIKGLIINFLDYFFPSLLRIPGFLVEFITPIVKISRAR-- 672

Query: 61  QKLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+ +F++ PEYE W  +N     W IKYYKGLG+ T  + +++F +++  R  F   +D 
Sbjct: 673 QERAFFTMPEYEAWKAENNDGRGWDIKYYKGLGTSTAADARKYFGDMDSHRLGFRVSDDA 732

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D   I++AF+K K  +R+  +  F    + D++   I   DF+ +E ILYSMA   R IP
Sbjct: 733 DRSLIDMAFNKKKADDRKDWLASFIPGTFLDHSIKQIPISDFVNRELILYSMADNIRSIP 792

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           SL+DG KP QRK+L+G FKR L  EI+V +L GYV+E SAYHH E+SL  T++ +A+++V
Sbjct: 793 SLVDGFKPGQRKVLFGCFKRNLKKEIKVAQLGGYVSEQSAYHHGEASLYGTIVGLAQNFV 852

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL  NGQFGT +QGGKD AS RYI+T +  I+R +F   D+ LL YL++DG S+
Sbjct: 853 GSNNINLLDPNGQFGTRLQGGKDAASARYIFTNVAQITRTIFHPADDNLLTYLSDDGQSI 912

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLND-DKLQPMVPWYKGF 358
           EP WY+P+IP+VLVNG  GI TGW+ +IP YNP DIIAN++  L D D+  P++PWY+G+
Sbjct: 913 EPSWYMPVIPMVLVNGSDGIGTGWSSTIPTYNPADIIANLRAKLADKDERIPLLPWYRGY 972

Query: 359 KGTI 362
           KG I
Sbjct: 973 KGEI 976


>M1HJQ6_9PHYC (tr|M1HJQ6) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus Can18-4 GN=Can18-4_668R PE=3 SV=1
          Length = 1058

 Score =  376 bits (966), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 184/367 (50%), Positives = 250/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I++
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDIKE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  EI+V +  GYV+E S YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLVQEIKVAQFSGYVSEISGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ I GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRILGGKDCASARYIFTKLSPVTRQVFNQADDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++   + PM PWYKGF G 
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKDMVPMTPWYKGFTGI 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>Q8ILC8_PLAF7 (tr|Q8ILC8) DNA topoisomerase 2 OS=Plasmodium falciparum (isolate
           3D7) GN=PF14_0316 PE=3 SV=1
          Length = 1472

 Score =  376 bits (965), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 181/358 (50%), Positives = 247/358 (68%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FLSE +TPI++     G Q+ SF
Sbjct: 569 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQK--GSQEYSF 626

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W +N     W+IKYYKGLG+ T  E K++F +++  +  F+W  D D D+I+
Sbjct: 627 FTIAEYEQWKENTNLLGWKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGDRDGDSID 686

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 687 MAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 746

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 747 KPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 806

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 807 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYI 866

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIKR++N + L PMVPWYK FKG I+
Sbjct: 867 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDFKGRIE 924


>Q7YZS4_PHYPO (tr|Q7YZS4) DNA topoisomerase 2 OS=Physarum polycephalum GN=TOP2 PE=2
            SV=1
          Length = 1498

 Score =  376 bits (965), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 173/361 (47%), Positives = 249/361 (68%), Gaps = 6/361 (1%)

Query: 6    YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
            YG+VM M DQD+DGSHIKGL +NF     PSLL    FL + ITPI++AFH   +Q  +F
Sbjct: 859  YGKVMLMTDQDHDGSHIKGLFVNFMIQFWPSLLEQDGFLEQFITPIVKAFHGAEVQ--TF 916

Query: 66   YSYPEYEKWWKNWGN---SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
            Y+  EYE W     +   S WRIKYYKGLG+ + +E +E+F+++E  R  F W +D    
Sbjct: 917  YTTSEYEIWRSQLPDDQLSKWRIKYYKGLGTSSSQEAREYFKDLERHRIEFKW-DDTTTT 975

Query: 123  AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
             +++AF K +T +R+          + DYT  ++ Y DF+ KE + +  A+  R IPS++
Sbjct: 976  KMDMAFGKDETAQRKTWAAAIPKDWFVDYTVKNLTYSDFVDKELVQFCRAANARAIPSVV 1035

Query: 183  DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
            DG KP QRK+LY +FKR L  E++V +L GYVAEH+AYHH E SL  T++ MA+D+VG+ 
Sbjct: 1036 DGLKPGQRKVLYASFKRGLTQEMKVAQLAGYVAEHTAYHHGEESLHGTIVNMAQDFVGAN 1095

Query: 243  NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
            N+ LL+ +GQFGT +QGGKD AS RYI+T+L P++R +FP++D+ +L YL  DG  ++PE
Sbjct: 1096 NLPLLLPSGQFGTRLQGGKDAASARYIFTKLAPLTRTIFPDLDDPVLNYLEGDGDRIQPE 1155

Query: 303  WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
            ++ PIIP+VLVNG  G+  GW  SIP YNP ++I N+ R L+++ ++P+ PWYKGFKG++
Sbjct: 1156 FFAPIIPMVLVNGSEGLGMGWRTSIPMYNPTNLIDNLLRLLHNEPMEPLTPWYKGFKGSV 1215

Query: 363  D 363
            +
Sbjct: 1216 E 1216


>Q4Y8Y8_PLACH (tr|Q4Y8Y8) DNA topoisomerase II, putative (Fragment) OS=Plasmodium
           chabaudi GN=PC000063.00.0 PE=4 SV=1
          Length = 937

 Score =  376 bits (965), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 179/358 (50%), Positives = 248/358 (69%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FL E +TPI++    N  Q+LSF
Sbjct: 61  YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLCEFVTPIVKVQKGN--QELSF 118

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W +N     W+IKYYKGLG+ T +E K++F +++  +  F+W  D D D+I+
Sbjct: 119 FTIAEYEQWKENTNLLGWKIKYYKGLGTSTDKEFKQYFSDIQSHKIVFLWTGDRDGDSID 178

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 179 MAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 238

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 239 KPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 298

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 299 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEFDDPILKYLNEEGQKIEPQYYI 358

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIK++++ + L PMVPWYK FKG I+
Sbjct: 359 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIINNIKKYIDKEPLVPMVPWYKDFKGRIE 416


>J3PRY3_PUCT1 (tr|J3PRY3) DNA topoisomerase 2 OS=Puccinia triticina (isolate 1-1
           / race 1 (BBBD)) GN=PTTG_01899 PE=3 SV=1
          Length = 1579

 Score =  376 bits (965), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 176/362 (48%), Positives = 244/362 (67%), Gaps = 3/362 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF     PSLL IP FL E ITPI++       +
Sbjct: 537 DSLRYGSLMIMTDQDHDGSHIKGLIINFLDYFFPSLLEIPGFLVEFITPIVKVTKKK--E 594

Query: 62  KLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           ++SF++ PE+EKW  +N G   W  KYYKGLG+   ++ K++F  +   R  F    + D
Sbjct: 595 EISFFTMPEFEKWKEENDGGRGWTSKYYKGLGTSDAKDAKKYFSRMSSHRIKFAPTQEND 654

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
              I++AF+K K  +R+  +  F+   + D     I Y +F+ KE IL+SMA   R IPS
Sbjct: 655 RSLIDMAFNKKKADDRKEWLRGFEPGTHLDQNVSQITYSEFINKELILFSMADNIRSIPS 714

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRK+L+  FKR+L  EI+V +L GY +EHSAYHH E+SL  T++ +A+++VG
Sbjct: 715 MVDGFKPGQRKVLFACFKRKLKAEIKVAQLGGYCSEHSAYHHGEASLTQTIVGLAQNFVG 774

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NIN+L  NGQFGT   GGKD AS RYI+T +  I+R +FP  D+ +L YL +DG  +E
Sbjct: 775 SNNINVLSPNGQFGTRASGGKDAASARYIFTNVEKITRVIFPPSDDNILTYLTDDGTQIE 834

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWY+P++P+VLVNG SGI TGW+  IP YNP DI+ N++R L D+ ++PM PW++GF G
Sbjct: 835 PEWYIPVLPMVLVNGSSGIGTGWSSDIPNYNPVDIVNNLRRRLADEPMEPMHPWFRGFTG 894

Query: 361 TI 362
            I
Sbjct: 895 QI 896


>M1H9T1_9PHYC (tr|M1H9T1) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus MN0810.1 GN=MN0810.1_698L PE=3 SV=1
          Length = 1056

 Score =  375 bits (964), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 180/367 (49%), Positives = 251/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI GL++NFF+   PSLL IP FL +  TPI+ A     +++
Sbjct: 475 SLRYGSVMLMTDADVDGSHITGLVVNFFHAQFPSLLEIPGFLKKFTTPIVIAKRGKDMKE 534

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             FYS P++E W K  G   W IKY KGLG+ T E+ K +F+N++   K F W +D   +
Sbjct: 535 --FYSLPDFEDWKKTSGEK-WSIKYLKGLGTSTSEDAKRYFKNLKGLTKVFGWTDDSS-E 590

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  ER+  +L F+  +  D T   I   DF+ KE IL+S   V R IPS++
Sbjct: 591 LIDRSFNKSRADERKTWLLDFEPGNQIDQTLTKIPMDDFIDKELILFSRYDVERSIPSVV 650

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRKIL+ AFK+ L +E +V +  GYV+EH+ YHH E SL   ++ MA+DYVGS 
Sbjct: 651 DGLKPSQRKILFSAFKKNLTSETKVAQFSGYVSEHAGYHHGEVSLQGAIVSMAQDYVGSN 710

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL+  GQFG+ + GGKD AS RYI+T+L+P +R +F + D+ LLKYL +DG  +EPE
Sbjct: 711 NINLLLPRGQFGSRLHGGKDSASARYIFTQLSPSTRDIFHKADDMLLKYLEDDGDKIEPE 770

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P++P + VNG +GI TG++ +IP YNPKDI+ N+KR +N++ + PM PWY+GFKGTI
Sbjct: 771 YYVPVVPWLAVNGANGIGTGFSTNIPSYNPKDIVDNVKRLINNETMLPMTPWYRGFKGTI 830

Query: 363 DKSIGGM 369
            ++  G+
Sbjct: 831 AEASPGV 837


>F4NTP0_BATDJ (tr|F4NTP0) DNA topoisomerase 2 (Fragment) OS=Batrachochytrium
           dendrobatidis (strain JAM81 / FGSC 10211)
           GN=BATDEDRAFT_18312 PE=3 SV=1
          Length = 1218

 Score =  375 bits (963), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 180/362 (49%), Positives = 248/362 (68%), Gaps = 3/362 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNG--IQKL 63
           YG +M M DQD+DGSHIKGL+INF     PSLL IP FL E ITPI+RA    G   Q++
Sbjct: 585 YGHLMIMTDQDHDGSHIKGLIINFLDHFWPSLLYIPGFLLEFITPIVRATKGKGHNKQEI 644

Query: 64  SFYSYPEYEKWWK-NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
           SF++ PE+E+W + N G   W  KY+KGLG+ T  + KE+F ++    K F   +DE  +
Sbjct: 645 SFFTIPEFEQWKEVNSGGRGWTTKYFKGLGTSTTADAKEYFSDMNKHLKPFCRLDDESRE 704

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I++AF+K K   R+  + +F+   Y D++   I   DF+ +E IL+SMA   R IPS +
Sbjct: 705 LIDMAFNKKKADSRKEWLGRFQPGTYMDHSVTEISLPDFINRELILFSMADNARSIPSSV 764

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KP QRKIL+  FKR L +EI+V +L GYVAEHSAYHH E SL  T++ MA++++GS 
Sbjct: 765 DGFKPGQRKILFACFKRNLKSEIKVAQLAGYVAEHSAYHHGEQSLNATIVNMAQNFIGSN 824

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           N+ +L   GQFGT +QGGKD ASPRYI+T L P++R +F   D+ LL YL +DG ++EPE
Sbjct: 825 NLGVLEPLGQFGTRLQGGKDAASPRYIFTNLTPLARTVFHPSDDPLLTYLVDDGQNIEPE 884

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           WYLP++P++LVNG  GI TGW+ SIP YNP+DI+  + R +  ++L  + PWY+GF G I
Sbjct: 885 WYLPVLPMLLVNGADGIGTGWSSSIPNYNPRDIVECLHRLMRHEELFEIHPWYRGFSGKI 944

Query: 363 DK 364
           ++
Sbjct: 945 ER 946


>G5AAW7_PHYSP (tr|G5AAW7) DNA topoisomerase 2 (Fragment) OS=Phytophthora sojae
           (strain P6497) GN=PHYSODRAFT_565596 PE=3 SV=1
          Length = 1289

 Score =  375 bits (963), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 180/359 (50%), Positives = 246/359 (68%), Gaps = 5/359 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M MADQD+DGSHIKGL+IN  +   PSLL +  FL E ITPI++     G  K  F
Sbjct: 630 YGHLMIMADQDHDGSHIKGLVINLIHHFWPSLLLVDGFLQEFITPIVKC--SKGRTKEVF 687

Query: 66  YSYPEYEKWWK--NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           Y+ PEYE W +  N G   W IKYYKGLG+ T  E KE+F ++   +  F +  + D D 
Sbjct: 688 YTMPEYEAWRERTNQGRG-WVIKYYKGLGTSTAAETKEYFSDLRTHQIGFTYGGEGDADV 746

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I++AFSK +  +R+  +  ++   Y DY    + Y DF+ KE IL+SMA   R IPS++D
Sbjct: 747 IDMAFSKKRVEDRKEWLRGYEPGTYVDYDVDEMGYTDFVNKELILFSMADNIRSIPSIVD 806

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KPSQRK+L+  FKR L +E++V +L GYV+EHSAYHH E+SL   ++ MA+D+VGS N
Sbjct: 807 GFKPSQRKVLFCCFKRNLRSELKVAQLAGYVSEHSAYHHGEASLQGCIVNMAQDFVGSNN 866

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           ++LL   GQFGT + GGKD AS RYI+T L  ++R ++  +DN +LKYL+EDG S+EPEW
Sbjct: 867 VHLLSPIGQFGTRLMGGKDAASARYIFTNLEQLTRRIYDPLDNDVLKYLDEDGQSIEPEW 926

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           Y+P+IP+VLVNG  GI TGW+ S+P YNP DII  +++ +N ++  P+ PWY+GF G I
Sbjct: 927 YIPVIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEASPLTPWYRGFTGHI 985


>M1HUY5_9PHYC (tr|M1HUY5) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus Canal-1 GN=Canal-1_581L PE=3 SV=1
          Length = 1058

 Score =  375 bits (963), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 177/368 (48%), Positives = 253/368 (68%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M+DQD DGSHI GL++NFF+   PSLL IP FL   +TPI+ A    G + 
Sbjct: 475 SLRYGSVMIMSDQDVDGSHIAGLVLNFFHAQFPSLLEIPGFLKRFVTPIVVA--KKGTKM 532

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + FYS P++E+W  +  + S W+ KYYKGLG+    + K +F N+++  K   W +D+  
Sbjct: 533 VEFYSIPDFEEWKSSTPDVSTWKTKYYKGLGTSDANDAKRYFNNLKVLVKTLTW-SDDAA 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           ++I+ +F+KS+  ER+  +L F+  +  D     I  +DF+ K+ IL+S   V R IPS+
Sbjct: 592 ESIDKSFNKSRADERKTWLLDFEPGNQLDQKLTKIPVEDFINKDLILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L +EI+V +  GYV+EH+ YHH E+SL   ++ +A+DYVGS
Sbjct: 652 VDGLKPSQRKILFSAFKRNLTSEIKVAQFAGYVSEHAGYHHGEASLQGAIVSIAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NINLL+  GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EP
Sbjct: 712 NNINLLVPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDKIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P IP +LVNG +GI TG++ +IP YNPKDI+ N+KR ++   + PM PWYKGFKG 
Sbjct: 772 EYYVPTIPFLLVNGANGIGTGFSTNIPSYNPKDIVDNVKRLIDGKPMTPMTPWYKGFKGA 831

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 832 IKETSPGV 839


>I3ESC1_NEMP1 (tr|I3ESC1) DNA topoisomerase 2 OS=Nematocida parisii (strain ERTm1
           / ATCC PRA-289) GN=NEPG_00303 PE=3 SV=1
          Length = 1182

 Score =  375 bits (962), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 183/369 (49%), Positives = 247/369 (66%), Gaps = 4/369 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           ES  YG +M M DQD+DGSHIKGL+IN      PSLL+I  FL E ITPI+RA    G  
Sbjct: 495 ESLRYGHLMIMTDQDHDGSHIKGLIINMLDHFFPSLLKIKGFLQEFITPIVRA--TKGSM 552

Query: 62  KLSFYSYPEYEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
              F++ PE+E W +     +  W+IKYYKGLG+ T ++ K++F N++   K F+  +  
Sbjct: 553 SRDFFTIPEFESWCETSEGRENGWKIKYYKGLGTSTAKDAKDYFSNLDFHIKEFIPMDST 612

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D I +AFSK +   R+  + +F    Y D    +I  K+F+ +E I +S+A   R IP
Sbjct: 613 DRDKIELAFSKKRIESRKVWLKEFVPGTYLDNRVQAISIKNFIDRELIHFSLADNIRSIP 672

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           ++IDG KP QRKI+Y  FKR+L +EI+V +L GYV+EHSAYHH E SL +T++ +A+DYV
Sbjct: 673 NVIDGMKPGQRKIIYCCFKRQLKSEIKVAQLAGYVSEHSAYHHGEQSLCSTIVNLAQDYV 732

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NI LL   GQFGT +QGGKD ASPRYI+T L  I+R++F E D+ LL YL +D + V
Sbjct: 733 GSNNIPLLQPIGQFGTRLQGGKDAASPRYIFTALQQITRYIFREQDDHLLNYLKDDNLMV 792

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP+ Y+PIIP+VLVNG  GI TGW+  IP YNP +I+ N+KR +N  + + M+PWYKGF 
Sbjct: 793 EPDMYIPIIPMVLVNGSEGIGTGWSTCIPSYNPIEIVDNVKRMINGHEPEDMMPWYKGFA 852

Query: 360 GTIDKSIGG 368
           G  +   GG
Sbjct: 853 GECEDLGGG 861


>I3EH32_NEMP3 (tr|I3EH32) DNA topoisomerase 2 OS=Nematocida parisii (strain
           ERTm3) GN=NEQG_01219 PE=3 SV=1
          Length = 1182

 Score =  375 bits (962), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 183/369 (49%), Positives = 247/369 (66%), Gaps = 4/369 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           ES  YG +M M DQD+DGSHIKGL+IN      PSLL+I  FL E ITPI+RA    G  
Sbjct: 495 ESLRYGHLMIMTDQDHDGSHIKGLIINMLDHFFPSLLKIKGFLQEFITPIVRA--TKGSM 552

Query: 62  KLSFYSYPEYEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
              F++ PE+E W +     +  W+IKYYKGLG+ T ++ K++F N++   K F+  +  
Sbjct: 553 SRDFFTIPEFESWCETSEGRENGWKIKYYKGLGTSTAKDAKDYFSNLDFHIKEFIPMDST 612

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D I +AFSK +   R+  + +F    Y D    +I  K+F+ +E I +S+A   R IP
Sbjct: 613 DRDKIELAFSKKRIESRKVWLKEFVPGTYLDNRVQAISIKNFIDRELIHFSLADNIRSIP 672

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           ++IDG KP QRKI+Y  FKR+L +EI+V +L GYV+EHSAYHH E SL +T++ +A+DYV
Sbjct: 673 NVIDGMKPGQRKIIYCCFKRQLKSEIKVAQLAGYVSEHSAYHHGEQSLCSTIVNLAQDYV 732

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NI LL   GQFGT +QGGKD ASPRYI+T L  I+R++F E D+ LL YL +D + V
Sbjct: 733 GSNNIPLLQPIGQFGTRLQGGKDAASPRYIFTALQQITRYIFREQDDHLLNYLKDDNLMV 792

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP+ Y+PIIP+VLVNG  GI TGW+  IP YNP +I+ N+KR +N  + + M+PWYKGF 
Sbjct: 793 EPDMYIPIIPMVLVNGSEGIGTGWSTCIPSYNPIEIVDNVKRMINGHEPEDMMPWYKGFA 852

Query: 360 GTIDKSIGG 368
           G  +   GG
Sbjct: 853 GECEDLGGG 861


>Q5CQG8_CRYPI (tr|Q5CQG8) DNA topoisomerase 2 OS=Cryptosporidium parvum (strain
            Iowa II) GN=cgd4_780 PE=3 SV=1
          Length = 1797

 Score =  375 bits (962), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 180/363 (49%), Positives = 252/363 (69%), Gaps = 8/363 (2%)

Query: 6    YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
            YG +M M DQD+DGSHIKGL+IN  +   PSL+    FL + +TPI++A    G  ++SF
Sbjct: 656  YGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLIHFRGFLKQFVTPIVKAKK--GSNEISF 713

Query: 66   YSYPEYEKWWKNWGNS--DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
            ++  EYE+W KN  ++   WR KYYKGLG+ T  E KE+F  +E     F W +D+D +A
Sbjct: 714  FTLYEYEQWRKNNSSNLNGWRFKYYKGLGTSTDLEFKEYFTKIENHSIEFDWMDDQDDEA 773

Query: 124  INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSIC----YKDFLQKEFILYSMASVRRCIP 179
            I++AFSK +T +R+  +  +K   Y DY+  + C    Y DF+ KE +L+S     R IP
Sbjct: 774  IDMAFSKKRTEDRKNWIESYKEGTYVDYSINNQCRNLRYFDFIHKELVLFSRYDTTRSIP 833

Query: 180  SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            +L+DG KP QRK+L+  FK++L  E++V +L GYVAEHSAYHH ESSL +T++ MA+++V
Sbjct: 834  NLLDGLKPGQRKVLFATFKKKLNNELKVAQLAGYVAEHSAYHHGESSLQSTIVNMAQNFV 893

Query: 240  GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
            GS N+NLL   GQFG+  +GGKD ++ RYI+T+L+  +R++FPE D+ LL YL +DG  +
Sbjct: 894  GSNNLNLLEPCGQFGSRKEGGKDASAARYIFTKLSKWTRYIFPEADDPLLTYLYDDGQQI 953

Query: 300  EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
            EP +Y+PIIP++LVNG  GI TGW+ S+P YNPKDII N+KR L  + + PM PWYK FK
Sbjct: 954  EPLYYVPIIPMILVNGTDGIGTGWSSSVPNYNPKDIIMNLKRMLKGEMMVPMTPWYKSFK 1013

Query: 360  GTI 362
            G I
Sbjct: 1014 GKI 1016


>O41065_PBCV1 (tr|O41065) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus 1 GN=A583L PE=3 SV=2
          Length = 1061

 Score =  375 bits (962), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 182/368 (49%), Positives = 253/368 (68%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++
Sbjct: 480 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLKKFITPIVVAKKGKDVRE 539

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F W +D   
Sbjct: 540 --FYSLPDYEDWVKTTKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKTLMKTFTWTSDSG- 596

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+K++  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS+
Sbjct: 597 ELIDRSFNKTRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSV 656

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRK+LY AFKR L ++++V +  GYVAEHSAYHH E SL  T++ +A+DYVGS
Sbjct: 657 VDGFKPSQRKVLYCAFKRNLTSDVKVAQFSGYVAEHSAYHHGEVSLQGTIVNLAQDYVGS 716

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EP
Sbjct: 717 NNINWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEP 776

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y+PIIP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWYKGFKG 
Sbjct: 777 ECYVPIIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYKGFKGK 836

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 837 IMETSPGV 844


>E6R0Q0_CRYGW (tr|E6R0Q0) DNA topoisomerase 2 OS=Cryptococcus gattii serotype B
           (strain WM276 / ATCC MYA-4071) GN=CGB_B4210C PE=3 SV=1
          Length = 1377

 Score =  375 bits (962), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 177/365 (48%), Positives = 254/365 (69%), Gaps = 3/365 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGL+INF     PSLLRIP FL E ITPI++ +   G 
Sbjct: 610 VDSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVW--KGK 667

Query: 61  QKLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +++SFY+ P+YE+W  +N     W  KYYKGLG+ T  + K++F +++  R  F     E
Sbjct: 668 KEISFYTMPQYEEWKAQNNNGRGWESKYYKGLGTSTSADAKKYFGDLDKHRLAFETMQPE 727

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D   I++AF+K K  +R+  + +FK   Y D+   S+   DF+ KE IL+SMA   R IP
Sbjct: 728 DRQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDIQSLPISDFVNKELILFSMADNIRSIP 787

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S+ DG KP QRK+L+G FKR L  EI+V +L GYV+E +AYHH E+SL +T++ +A+++V
Sbjct: 788 SVADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQNFV 847

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL  NGQFGT + GGKD AS RYI+T L  ++R +F   D+ LL YL EDG+S+
Sbjct: 848 GSNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLIEDGMSI 907

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP++++P +P+VL+NG  GI TGW+ +IP YNP DI+ N++R +  ++ + M PW++GFK
Sbjct: 908 EPDYFMPTVPMVLINGADGIGTGWSTAIPNYNPVDIVENLRRMMRGEEPEEMTPWFRGFK 967

Query: 360 GTIDK 364
           G+I++
Sbjct: 968 GSIER 972


>B3LBF9_PLAKH (tr|B3LBF9) DNA topoisomerase 2 OS=Plasmodium knowlesi (strain H)
           GN=PKH_131580 PE=3 SV=1
          Length = 1506

 Score =  374 bits (961), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 179/358 (50%), Positives = 248/358 (69%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FLSE +TPI++    N  Q+ SF
Sbjct: 569 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQKGN--QEHSF 626

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W ++     W+IKYYKGLG+ T +E K++F +++  +  F+W  D D D+I+
Sbjct: 627 FTIAEYEEWKESTNLVGWKIKYYKGLGTSTDKEFKQYFSDIKNHKIMFLWTGDRDGDSID 686

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 687 MAFSKKRIEDRKIWLQNFVIGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 746

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 747 KPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 806

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 807 FLEPCGQFGSRKEGGKDASAARYIFTKLASCTRSIFNEYDDPILKYLNEEGQKIEPKYYI 866

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIKR++N + L PM+PWYK FKG I+
Sbjct: 867 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIIENIKRYINKEPLIPMIPWYKDFKGRIE 924


>A5K0R4_PLAVS (tr|A5K0R4) DNA topoisomerase 2 OS=Plasmodium vivax (strain
           Salvador I) GN=PVX_084855 PE=3 SV=1
          Length = 1502

 Score =  374 bits (961), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 179/358 (50%), Positives = 248/358 (69%), Gaps = 2/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FLSE +TPI++    N  Q+ SF
Sbjct: 580 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQKGN--QEHSF 637

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W ++     W+IKYYKGLG+ T +E K++F +++  +  F+W  D D D+I+
Sbjct: 638 FTIAEYEQWKESTNLVGWKIKYYKGLGTSTDKEFKQYFSDIKNHKIMFLWTGDRDGDSID 697

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 698 MAFSKKRIEDRKLWLQNFIIGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 757

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 758 KPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 817

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 818 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYI 877

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIKR++N + L PM+PWYK FKG I+
Sbjct: 878 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIIENIKRYINKEPLLPMIPWYKDFKGRIE 935


>I4YK24_WALSC (tr|I4YK24) DNA topoisomerase 2 OS=Wallemia sebi (strain ATCC
           MYA-4683 / CBS 633.66) GN=WALSEDRAFT_14295 PE=3 SV=1
          Length = 1322

 Score =  374 bits (959), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 179/360 (49%), Positives = 251/360 (69%), Gaps = 3/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD+DGSHIKGLLIN+F    PSLL+IP FL E ITPII+ F  N  +++SF
Sbjct: 544 YGSIMIMTDQDHDGSHIKGLLINYFDHFYPSLLKIPGFLVEFITPIIKLFKRN--KEVSF 601

Query: 66  YSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           ++ PE+E W  +N     WR+KYYKGLG+ + EE +++F+ ++  R  F    + D + I
Sbjct: 602 FTIPEFEHWKAENDEGRGWRLKYYKGLGTSSDEEARQYFKALDRHRIPFSATQEGDRELI 661

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AF+K +T +R+  +  +    + D     + YKDF+ KE IL+SMA   R IPS++DG
Sbjct: 662 DMAFNKKRTEDRKEWLRGYNPRTFLDQDIEELSYKDFINKELILFSMADNARSIPSMVDG 721

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRKILYG  KR L  EI+V +L   VAE++AYHH E+ L  T++ MA+++VGS N+
Sbjct: 722 FKPGQRKILYGTIKRNLKNEIKVAQLGMSVAENTAYHHGETILFQTIVGMAQNFVGSNNL 781

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           N+L  NGQFG+  +GGKD A+ RYI+T +  I+R +F   D+ +L YL ED   +EPEWY
Sbjct: 782 NILSPNGQFGSRREGGKDAAAARYIFTAIPRITRTIFHPDDDPILTYLKEDDEWIEPEWY 841

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PIIP+VLVNG  GI TGW+ +IP YNP D++ANI+R LN+  +QPM+PWY+GF G I++
Sbjct: 842 VPIIPMVLVNGADGIGTGWSTTIPNYNPSDLVANIRRKLNNQDIQPMIPWYRGFTGNIER 901


>M9LUR2_9BASI (tr|M9LUR2) Uncharacterized protein OS=Pseudozyma antarctica T-34
            GN=PANT_8d00062 PE=4 SV=1
          Length = 2299

 Score =  374 bits (959), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 175/369 (47%), Positives = 251/369 (68%), Gaps = 3/369 (0%)

Query: 1    MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
            + S  YG +M M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPI++     G 
Sbjct: 1570 VNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVKC--TKGK 1627

Query: 61   QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            Q+LSF++ PEY  W +   N   WRIKY+KGLG+   ++ K++F+ ++     F    D 
Sbjct: 1628 QELSFFTIPEYMTWKEQHNNGKGWRIKYFKGLGTSDSQDAKKYFRAMDKHMLPFDVTKDG 1687

Query: 120  DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
            D + I++AF+K K  +R+  + +F+   Y D+   +I Y DF+ KE IL+SMA   R IP
Sbjct: 1688 DRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNIDTIPYADFINKELILFSMADNLRSIP 1747

Query: 180  SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            S +DG KP QRK+++G F R    EI+V +L+G++   +AYHH ++SL  T++ +A+++V
Sbjct: 1748 SAVDGLKPGQRKVIFGTFNRRGDGEIKVAQLVGHIIGTTAYHHGDASLTMTIVGLAQNFV 1807

Query: 240  GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
            GS N+NLL   GQFGT + GGKD AS RYI+T L  I+R LFP+ D+ LL +L++DG S+
Sbjct: 1808 GSNNVNLLEPRGQFGTRLLGGKDAASARYIFTALPKITRALFPQADDALLNFLDDDGQSI 1867

Query: 300  EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
            EPEWY+P++P VL+NG  GI TGW+ S+P YNP +I+ANI+R +  +++ PM PWY+GF 
Sbjct: 1868 EPEWYMPVVPQVLMNGAEGIGTGWSTSVPNYNPHEIVANIRRRMAGEEVVPMKPWYRGFT 1927

Query: 360  GTIDKSIGG 368
            G ID+   G
Sbjct: 1928 GDIDEVAPG 1936


>Q5KP97_CRYNJ (tr|Q5KP97) DNA topoisomerase 2 OS=Cryptococcus neoformans var.
           neoformans serotype D (strain JEC21 / ATCC MYA-565)
           GN=CNA03600 PE=3 SV=1
          Length = 1272

 Score =  374 bits (959), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 177/364 (48%), Positives = 252/364 (69%), Gaps = 3/364 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF     PSLLRIP FL E ITPI++ +   G +
Sbjct: 612 DSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVW--KGKK 669

Query: 62  KLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           ++SFY+ P+YE+W  +N     W  KYYKGLG+ T  + K++F +++  R  F     ED
Sbjct: 670 EISFYTMPQYEEWKAQNNNGRGWESKYYKGLGTSTSADAKKYFSDLDKHRLAFETMQPED 729

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
              I++AF+K K  +R+  + +FK   Y D+   S+   DF+ KE IL+SMA   R IPS
Sbjct: 730 RQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDVQSLPISDFVNKELILFSMADNIRSIPS 789

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           + DG KP QRK+L+G FKR L  EI+V +L GYV+E +AYHH E+SL +T++ +A+++VG
Sbjct: 790 VADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQNFVG 849

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL  NGQFGT + GGKD AS RYI+T L  ++R +F   D+ LL YL EDG+S+E
Sbjct: 850 SNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLVEDGMSIE 909

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P++++P +P+VL+NG  GI TGW+ +IP YNP DI+ N++R +  ++ + M PW++GFKG
Sbjct: 910 PDYFMPTVPMVLINGADGIGTGWSTAIPNYNPVDIVENLRRMMRGEEPEKMTPWFRGFKG 969

Query: 361 TIDK 364
            I++
Sbjct: 970 FIER 973


>F5HDJ4_CRYNB (tr|F5HDJ4) DNA topoisomerase 2 OS=Cryptococcus neoformans var.
           neoformans serotype D (strain B-3501A) GN=CNBA3470 PE=3
           SV=1
          Length = 1272

 Score =  374 bits (959), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 177/364 (48%), Positives = 252/364 (69%), Gaps = 3/364 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF     PSLLRIP FL E ITPI++ +   G +
Sbjct: 612 DSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVW--KGKK 669

Query: 62  KLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           ++SFY+ P+YE+W  +N     W  KYYKGLG+ T  + K++F +++  R  F     ED
Sbjct: 670 EISFYTMPQYEEWKAQNNNGRGWESKYYKGLGTSTSADAKKYFSDLDKHRLAFETMQPED 729

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
              I++AF+K K  +R+  + +FK   Y D+   S+   DF+ KE IL+SMA   R IPS
Sbjct: 730 RQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDVQSLPISDFVNKELILFSMADNIRSIPS 789

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           + DG KP QRK+L+G FKR L  EI+V +L GYV+E +AYHH E+SL +T++ +A+++VG
Sbjct: 790 VADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQNFVG 849

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL  NGQFGT + GGKD AS RYI+T L  ++R +F   D+ LL YL EDG+S+E
Sbjct: 850 SNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLVEDGMSIE 909

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P++++P +P+VL+NG  GI TGW+ +IP YNP DI+ N++R +  ++ + M PW++GFKG
Sbjct: 910 PDYFMPTVPMVLINGADGIGTGWSTAIPNYNPVDIVENLRRMMRGEEPEKMTPWFRGFKG 969

Query: 361 TIDK 364
            I++
Sbjct: 970 FIER 973


>M1HXD2_9PHYC (tr|M1HXD2) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus IL-5-2s1 GN=IL-5-2s1_829L PE=3 SV=1
          Length = 1063

 Score =  374 bits (959), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 180/365 (49%), Positives = 253/365 (69%), Gaps = 4/365 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG VM M D D DG+HI GL++NFF+   PSLL IP FL + ITPI+ A     +++  F
Sbjct: 484 YGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEIPGFLRKFITPIVVAKRGKDVRE--F 541

Query: 66  YSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           YS P+YE W K   + S ++IKYYKGLG+ +  + K +F N++   K F W +D   + I
Sbjct: 542 YSLPDYEDWMKITKDYSKYQIKYYKGLGTSSSTDAKHYFSNLKTLMKTFTWTSDSG-ELI 600

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           + +F+K++  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS++DG
Sbjct: 601 DRSFNKTRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSVVDG 660

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KPSQRK+LY AFKR L ++++V +  GYVAEHSAYHH E SL  T++ +A+DYVGS NI
Sbjct: 661 FKPSQRKVLYCAFKRNLTSDVKVAQFSGYVAEHSAYHHGEVSLQGTIVNLAQDYVGSNNI 720

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           N L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EPE+Y
Sbjct: 721 NWLLPEGQFGSRLQGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEPEYY 780

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +P+IP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWYKGFKG I +
Sbjct: 781 VPVIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYKGFKGKIME 840

Query: 365 SIGGM 369
           +  G+
Sbjct: 841 TSPGV 845


>M1ILU4_9PHYC (tr|M1ILU4) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus OR0704.3 GN=OR0704.3_647L PE=3 SV=1
          Length = 1056

 Score =  373 bits (958), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 181/367 (49%), Positives = 248/367 (67%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI GL++NFF+   PSLL IP FL +  TPI+ A     + +
Sbjct: 475 SLRYGSVMLMTDADVDGSHIAGLVLNFFHAQFPSLLEIPGFLKKFTTPIVIAKRGKDMNE 534

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             FYS P++E W K  G+  W +KY KGLG+ T E+ K +F+N++   K F W +D   +
Sbjct: 535 --FYSLPDFEDWKKTSGDK-WSVKYLKGLGTSTSEDAKRYFKNLKGLTKVFGWTDDSS-E 590

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  ER+  +L F+  +  D T   I   DFL KE IL+S   V R IPS++
Sbjct: 591 LIDRSFNKSRADERKTWLLNFEPGNQLDQTLTKIPVDDFLNKELILFSRYDVERSIPSVV 650

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRKIL+ AF+R L +EI+V +  GY +EH+ YHH E+SL   ++ MA+DYVGS 
Sbjct: 651 DGLKPSQRKILFSAFRRNLTSEIKVAQFAGYTSEHAGYHHGEASLQGAIIGMAQDYVGSN 710

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL EDG  +EPE
Sbjct: 711 NINLLAPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEEDGDKIEPE 770

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P IP +LVNG +GI TG++ +IP YNPK+II N+KR ++   + PM PWY+GFKGTI
Sbjct: 771 YYVPTIPFLLVNGANGIGTGFSTNIPSYNPKEIIDNVKRLIDGKPMVPMTPWYRGFKGTI 830

Query: 363 DKSIGGM 369
            ++  G+
Sbjct: 831 VEASPGV 837


>A7J7Q3_PBCVF (tr|A7J7Q3) Putative uncharacterized protein N549R OS=Paramecium
           bursaria Chlorella virus FR483 GN=N549R PE=3 SV=1
          Length = 1058

 Score =  373 bits (957), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 182/367 (49%), Positives = 250/367 (68%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I +
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDINE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W +N  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKQNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLDFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  EI+V +  GYV+E S YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLVQEIKVAQFSGYVSEISGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL+ NGQFG+ + GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+EP
Sbjct: 712 NNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPVTRQVFNQADDVLLKYLEDDGSSIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           EWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR ++  ++ PM PWYK F G+
Sbjct: 772 EWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLISGKEMVPMSPWYKEFTGS 831

Query: 362 IDKSIGG 368
           I ++  G
Sbjct: 832 IVQNDNG 838


>A8Q990_BRUMA (tr|A8Q990) DNA topoisomerase 2 OS=Brugia malayi GN=Bm1_46835 PE=3
           SV=1
          Length = 1570

 Score =  373 bits (957), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 181/377 (48%), Positives = 256/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M +  YG++M MADQD DGSHIKGL+INF +   P L+R   F+ E ITPI++A    G 
Sbjct: 578 MRTLRYGKIMVMADQDQDGSHIKGLVINFIHYNWPVLIR-RNFVEEFITPIVKA--TKGK 634

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           + LSF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  +E
Sbjct: 635 ESLSFFSLPEYAEWRNNTENWKTYRIKYYKGLGTSTSKEAKEYFTDMIRHRIRFQYSGEE 694

Query: 120 DLDAINIAFSKSKTRERR----GLMLKFKSSDYRDYTD--------LSICYKDFLQKEFI 167
           D  ++++AFSK K  +R+      M + K+   +  T+         ++ +KDF+ KE +
Sbjct: 695 DDSSLDMAFSKKKIEDRKVWLTNWMAEKKTRREQGLTEEYLYDKDTRAVSFKDFVNKELV 754

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S A   R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 755 LFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 814

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP++R LFP +D  
Sbjct: 815 MSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTRALFPAVDEN 874

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  IP YNP++I+ N++R +  ++
Sbjct: 875 VLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKIPNYNPREIVDNMRRLIRGEE 934

Query: 348 LQPMVPWYKGFKGTIDK 364
            +P++PW+K F+GTI+K
Sbjct: 935 PKPLIPWFKNFRGTIEK 951


>E3JRR8_PUCGT (tr|E3JRR8) DNA topoisomerase 2 OS=Puccinia graminis f. sp. tritici
           (strain CRL 75-36-700-3 / race SCCL) GN=PGTG_00741 PE=3
           SV=2
          Length = 1613

 Score =  373 bits (957), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 177/368 (48%), Positives = 244/368 (66%), Gaps = 3/368 (0%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF     PSLL IP FL E ITPI++       +
Sbjct: 623 DSLRYGSLMIMTDQDHDGSHIKGLIINFLDYFFPSLLEIPGFLVEFITPIVKVTRKK--E 680

Query: 62  KLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +LSF++ PE+EKW  +N     W  KYYKGLG+   ++ K++F  +   R  F    + D
Sbjct: 681 ELSFFTMPEFEKWKEENDDGRGWTSKYYKGLGTSDAKDAKKYFSRMSSHRIKFAPTQEND 740

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
              I++AF+K K  +R+  +  F+   + D     I Y +F+ KE IL+SMA   R IPS
Sbjct: 741 RHLIDMAFNKKKADDRKEWLRGFEPGTHLDQNVSQITYTEFINKELILFSMADNIRSIPS 800

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRK+L+  FKR+L  EI+V +L GY +EHSAYHH E+SL  T++ +A+++VG
Sbjct: 801 MVDGFKPGQRKVLFACFKRKLKAEIKVAQLGGYCSEHSAYHHGEASLTQTIVGLAQNFVG 860

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NIN+L  NGQFGT   GGKD AS RYI+T +  I+R +FP  D+ +L YL +DG  +E
Sbjct: 861 SNNINVLSPNGQFGTRASGGKDAASARYIFTNVEKITRVIFPPADDNVLNYLTDDGTQIE 920

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWY+PI+P+VLVNG SGI TGW+  IP YNP DI+ N++R L ++ ++PM PW++GF G
Sbjct: 921 PEWYIPILPMVLVNGSSGIGTGWSSDIPNYNPVDIVNNLRRRLANEPMEPMHPWFRGFTG 980

Query: 361 TIDKSIGG 368
            I     G
Sbjct: 981 QITSEAPG 988


>M1IMS0_9PHYC (tr|M1IMS0) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus TN603.4.2 GN=TN603.4.2_633L PE=3 SV=1
          Length = 1066

 Score =  373 bits (957), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 181/367 (49%), Positives = 249/367 (67%), Gaps = 4/367 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI GL++NFF+   PSLL IP FL +  TPI+ A     +++
Sbjct: 485 SLRYGSVMLMTDADVDGSHIAGLVLNFFHAQFPSLLEIPGFLKKFTTPIVIAKRGKDMKE 544

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             FYS P++E W K  G+  W +KY KGLG+ T E+ K +F+N++   K F W +D   +
Sbjct: 545 --FYSLPDFEDWKKTSGDK-WSVKYLKGLGTSTSEDAKRYFKNLKGLTKVFGWTDDSS-E 600

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  ER+  +L F+  +  D T   I   DFL KE IL+S   V R IPS++
Sbjct: 601 LIDRSFNKSRADERKTWLLDFEPGNQLDQTLTKIPVDDFLNKELILFSRYDVERSIPSVV 660

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRKIL+ AF+R L +EI+V +  GY +EH+ YHH E+SL   ++ MA+DYVGS 
Sbjct: 661 DGLKPSQRKILFSAFRRNLTSEIKVAQFAGYTSEHAGYHHGEASLQGAIIGMAQDYVGSN 720

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NINLL   GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL EDG  +EPE
Sbjct: 721 NINLLAPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEEDGDKIEPE 780

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P IP +LVNG +GI TG++ +IP YNPK+II N+KR ++   + PM PWY+GFKGTI
Sbjct: 781 YYVPTIPFLLVNGANGIGTGFSTNIPSYNPKEIIDNVKRLIDGKPMVPMTPWYRGFKGTI 840

Query: 363 DKSIGGM 369
            ++  G+
Sbjct: 841 VEASPGV 847


>H6BPZ5_EXODN (tr|H6BPZ5) DNA topoisomerase 2 OS=Exophiala dermatitidis (strain
           ATCC 34100 / CBS 525.76 / NIH/UT8656)
           GN=HMPREF1120_01903 PE=3 SV=1
          Length = 1661

 Score =  372 bits (956), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 180/361 (49%), Positives = 243/361 (67%), Gaps = 4/361 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC---NGIQK 62
           YG +M M DQD+DGSHIKGLLINF  +  PSLL+IP FL E ITPI++ +     N  Q 
Sbjct: 635 YGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPKFLVEFITPIVKVYRGDPKNPSQS 694

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            +FY+ PEYE W +   +   W  KYYKGLG+ T E+ +++F +++   K F    DE+ 
Sbjct: 695 RAFYTMPEYEAWKEAHKHERGWEHKYYKGLGTSTSEDAQQYFNDIDKHHKEFDVMKDEEA 754

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
             I +AFSK K  ER+  + +FK+  Y D++   I Y DF+ KE IL+SMA   R IPS+
Sbjct: 755 SLIELAFSKKKADERKEWLRQFKAGTYLDHSAKIISYSDFVNKELILFSMADNVRSIPSV 814

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KP QRK++Y  FKR L  +++V +L G V+  +AYHH E+SL  T++ +A+D+VGS
Sbjct: 815 VDGLKPGQRKVMYACFKRNLKKDMKVAELAGLVSGMTAYHHGEASLQQTIVGLAQDFVGS 874

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+NLL  +GQFGT  QGG D AS RYI+T L+P +R LF   D  LLKY  +D  ++EP
Sbjct: 875 NNVNLLEPSGQFGTRNQGGNDCASARYIHTRLSPFARKLFHTDDEALLKYNTDDERTIEP 934

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y PIIP+VLVNG  GI TGW+  IP YNP+DI+ N+KR +N +  +PM PWY+GFKG 
Sbjct: 935 EVYAPIIPMVLVNGADGIGTGWSSYIPNYNPEDIVENLKRRMNGEDWKPMQPWYRGFKGE 994

Query: 362 I 362
           +
Sbjct: 995 V 995


>M1IDW0_9PHYC (tr|M1IDW0) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus NE-JV-2 GN=NE-JV-2_681L PE=3 SV=1
          Length = 1058

 Score =  372 bits (955), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 176/368 (47%), Positives = 249/368 (67%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M+DQD DGSHI GL++NFF+   PSLL IP FL   +TPI+ A    G + 
Sbjct: 475 SLRYGSVMIMSDQDVDGSHIAGLVLNFFHAQFPSLLEIPGFLKRFVTPIVVA--KKGTKM 532

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + FYS P++E+W     + S W+ KYYKGLG+    + K +F N+++  K   W +D+  
Sbjct: 533 VEFYSIPDFEEWKAATPDVSTWKTKYYKGLGTSDSNDAKRYFNNLKVLVKTLTW-SDDAA 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           ++I+ +F+KS+  ER+  +L FK  +  D     I  +DF+ K+ IL+S   V R IPS+
Sbjct: 592 ESIDKSFNKSRADERKTWLLDFKPGNQLDQKLTKIPVEDFINKDLILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AF+R L  EI+V +  GYV+EH+ YHH E+SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFSAFRRNLVQEIKVAQFAGYVSEHAGYHHGEASLQGAIVSMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NINLL+  GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EP
Sbjct: 712 NNINLLVPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDKIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P +P +LVNG +GI TG++ +IP YNPKDI+ N+KR +N   +  M PWYK FKG 
Sbjct: 772 EYYVPTVPFLLVNGANGIGTGFSTNIPSYNPKDIVDNVKRLINGKAMTEMTPWYKNFKGE 831

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 832 IKETSPGV 839


>F1Q8Y8_DANRE (tr|F1Q8Y8) DNA topoisomerase 2 OS=Danio rerio GN=top2b PE=2 SV=1
          Length = 1613

 Score =  372 bits (954), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 189/376 (50%), Positives = 248/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YGR+M M DQD DGSHIKGLLINFF+   PSLL+   FL E ITPI++A      
Sbjct: 543 LKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HTFLEEFITPIVKA--SKNK 599

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q++SFYS PE+E+W K+  +   W IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 600 QEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTE 659

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK KT +R+  +  F   D R               +   + Y DF+ KE 
Sbjct: 660 DDAAITLAFSKKKTDDRKEWLTNF-MEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKEL 718

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 719 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQA 778

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+N+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP +D+
Sbjct: 779 LMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDS 838

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ NI R LN  
Sbjct: 839 SLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQ 898

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 899 DPLPMLPSYKNFKGTI 914


>Q1LUT2_DANRE (tr|Q1LUT2) Uncharacterized protein OS=Danio rerio GN=top2b PE=2
           SV=1
          Length = 1618

 Score =  372 bits (954), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 189/376 (50%), Positives = 248/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YGR+M M DQD DGSHIKGLLINFF+   PSLL+   FL E ITPI++A      
Sbjct: 548 LKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HTFLEEFITPIVKA--SKNK 604

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q++SFYS PE+E+W K+  +   W IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 605 QEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTE 664

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK KT +R+  +  F   D R               +   + Y DF+ KE 
Sbjct: 665 DDAAITLAFSKKKTDDRKEWLTNF-MEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKEL 723

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 724 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQA 783

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+N+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP +D+
Sbjct: 784 LMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDS 843

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ NI R LN  
Sbjct: 844 SLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQ 903

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 904 DPLPMLPSYKNFKGTI 919


>L7MAX8_9ACAR (tr|L7MAX8) DNA topoisomerase 2 (Fragment) OS=Rhipicephalus
            pulchellus PE=2 SV=1
          Length = 1662

 Score =  371 bits (953), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 186/380 (48%), Positives = 258/380 (67%), Gaps = 22/380 (5%)

Query: 1    MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
            +++  YGR+M M DQD DGSHIKGLLINF +   PSLL++P FL E ITPI++A    G 
Sbjct: 635  LKTLRYGRLMIMTDQDQDGSHIKGLLINFIHHNWPSLLKLP-FLEEFITPIVKA--TKGK 691

Query: 61   QKLSFYSYPEYEKW---WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
             +LSFYS PE+E+W     +W    W++KYYKGLG+ T +E KE+F ++   R  F ++ 
Sbjct: 692  TELSFYSLPEFEEWKAATDDW--QRWKVKYYKGLGTSTAKEAKEYFIDMARHRIKFKYQG 749

Query: 118  DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDL-------------SICYKDFLQK 164
             ED  AI +AFSK K  E+R   L+    + +   +L             +I Y+DF+ K
Sbjct: 750  GEDDRAIELAFSK-KMIEQRKEWLRNGMEERKQRRELGLPEVYLYGKDTRNITYEDFVNK 808

Query: 165  EFILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDE 224
            E IL+S     R IPSL+DG KP QRK+LY  FKR    EI+V +L G VAEHSAYHH E
Sbjct: 809  ELILFSNMDNERSIPSLVDGLKPGQRKVLYTCFKRNDKREIKVAQLAGSVAEHSAYHHGE 868

Query: 225  SSLATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEI 284
             SL +T++ +A+++VGS NINLL   GQFGT +QGGKD ASPRYI+T L+P++R + P  
Sbjct: 869  VSLMSTIINLAQNFVGSNNINLLQPIGQFGTRLQGGKDAASPRYIFTMLSPLARLIMPAS 928

Query: 285  DNKLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLN 344
            D+ +L YL +D   +EPE+Y+PI+P+VLVNG  GI TGW+  IP YNP++I+AN+++ LN
Sbjct: 929  DDPILDYLFDDNQRIEPEYYIPILPMVLVNGAEGIGTGWSTKIPNYNPREIVANLRKMLN 988

Query: 345  DDKLQPMVPWYKGFKGTIDK 364
             ++ +PM PW+K F+G++D+
Sbjct: 989  GEETKPMKPWFKNFRGSVDQ 1008


>M1I7P4_9PHYC (tr|M1I7P4) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus NY-2B GN=NY-2B_805L PE=3 SV=1
          Length = 1062

 Score =  371 bits (953), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 176/367 (47%), Positives = 252/367 (68%), Gaps = 3/367 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   P+LL IP FL + ITPI+ A    G + 
Sbjct: 481 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPNLLEIPGFLKKFITPIVVARK--GKEV 538

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             F+S P++E + K      W  KY+KGLG+ +  + K++F N++   K F+W +D   +
Sbjct: 539 REFFSLPDFEDFVKTQDMKKWTTKYFKGLGTSSSADAKKYFSNLKSLMKTFMWTSDSG-E 597

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS++
Sbjct: 598 LIDRSFNKSRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSVV 657

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRK+LY AFKR L T+++V +  GYVAEHSAYHH E+SL  T++ +A+DYVGS 
Sbjct: 658 DGFKPSQRKVLYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEASLQGTIVNLAQDYVGSN 717

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EPE
Sbjct: 718 NINWLLPEGQFGSRLQGGKDHASARYIFTKLNPQTRQVFVDTDDNLLKYLYDDGDKIEPE 777

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P+IP +LVNG SGI TGW+ +IP YNPKDI+ N+KR +  + L  M PW++GFKG I
Sbjct: 778 YYVPVIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLIAGEDLVEMKPWFRGFKGKI 837

Query: 363 DKSIGGM 369
           +++  G+
Sbjct: 838 EETSPGV 844


>J4C854_THEOR (tr|J4C854) DNA topoisomerase 2 OS=Theileria orientalis strain
           Shintoku GN=TOT_020000455 PE=3 SV=1
          Length = 2103

 Score =  371 bits (953), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 174/360 (48%), Positives = 254/360 (70%), Gaps = 1/360 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG VM M DQDYDGSHIKGLLIN F+   P L++   F+ E +TP+I+     G Q LSF
Sbjct: 512 YGSVMIMTDQDYDGSHIKGLLINLFHNFWPKLIQFNGFIREFVTPLIKVTSKAG-QVLSF 570

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  ++ +W +    + ++IKYYKGLG+ + +E KE+F N+      F + +++D D+I+
Sbjct: 571 FTMEDFNRWKETVDITSYKIKYYKGLGTSSDKEFKEYFSNLNRHLIEFNYVDNKDDDSID 630

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  M  +   +  D++   + Y DF+ KE I +S+    R IPS+IDG 
Sbjct: 631 MAFSKKRIEDRKNWMQNYTLGNTVDHSIKKLRYSDFINKELIQFSIYDTERSIPSVIDGF 690

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+L+G FKR L  E +V +L GY+AEHSAYHH E+SL  T++ MA+D+VGS N+N
Sbjct: 691 KPGQRKVLFGCFKRNLKNECKVAQLTGYIAEHSAYHHGENSLQQTIVNMAQDFVGSNNLN 750

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
           LL+  GQFG+  +GGKD A+ RYI+T+L P++R++F + D+ +L Y NE+G  VEP +YL
Sbjct: 751 LLLPCGQFGSRKEGGKDAAAARYIFTKLAPLTRYVFLQEDDPILDYQNEEGQLVEPFYYL 810

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDKS 365
           PIIP+VLVNG  GI TG++ ++PCYNP D+I NIK +L ++++  MVPWYKGFKGTI+++
Sbjct: 811 PIIPMVLVNGSEGIGTGFSTNVPCYNPIDVIENIKNYLRNEEMFEMVPWYKGFKGTIERN 870


>A7RCG0_PBCVA (tr|A7RCG0) Putative uncharacterized protein C707L OS=Paramecium
           bursaria Chlorella virus AR158 GN=C707L PE=3 SV=1
          Length = 1062

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 174/363 (47%), Positives = 251/363 (69%), Gaps = 3/363 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   P+LL IP FL + ITPI+ A     +++
Sbjct: 481 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPNLLEIPGFLKKFITPIVVARKGKEVRE 540

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             F+S P++E + K      W  KY+KGLG+ +  + K++F N++   K F+W +D   +
Sbjct: 541 --FFSLPDFEDFVKTQDMKKWTTKYFKGLGTSSSADAKKYFSNLKSLMKTFMWTSDSG-E 597

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS++
Sbjct: 598 LIDRSFNKSRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSVV 657

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRK++Y AFKR L T+++V +  GYVAEHSAYHH E+SL  T++ +A+DYVGS 
Sbjct: 658 DGFKPSQRKVIYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEASLQGTIVNLAQDYVGSN 717

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NIN L+  GQFG+ +QGGKDHAS RYI+T+LNP +R +F + D+ LLKYL +DG  +EPE
Sbjct: 718 NINWLLPEGQFGSRLQGGKDHASARYIFTKLNPQTRQVFVDTDDNLLKYLYDDGDKIEPE 777

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P+IP +LVNG SGI TGW+ +IP YNPKDI+ N+KR +  + L  M PWY+GFKG I
Sbjct: 778 YYVPVIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLIAGEDLVEMKPWYRGFKGKI 837

Query: 363 DKS 365
           +++
Sbjct: 838 EET 840


>J9D3E4_EDHAE (tr|J9D3E4) DNA topoisomerase 2 OS=Edhazardia aedis (strain USNM
           41457) GN=EDEG_03483 PE=3 SV=1
          Length = 1226

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 181/363 (49%), Positives = 244/363 (67%), Gaps = 1/363 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGLLINF     PSLLRI  FL   ITPI+R    N  
Sbjct: 543 VASLRYGHIMIMTDQDHDGSHIKGLLINFLDHFFPSLLRIKSFLQVFITPIVRVSKKNAQ 602

Query: 61  QKLSFYSYPEYEKWWKNW-GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
             + F++ PE+ KW     G+  ++IKYYKGLG+ T  + K +F N+    K F      
Sbjct: 603 GTIDFFTLPEFYKWQAETPGSEQYKIKYYKGLGTSTSADAKFYFSNLPKHVKNFDELTAS 662

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D + +N+AF+K K  +R+  +  +    + D +   I   DF+ KE IL+SMA   R IP
Sbjct: 663 DKELLNLAFNKKKADQRKSWLKNWAPGVFLDNSVPQISISDFVNKELILFSMADNIRSIP 722

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            L+DG KP QRK+L+  FKR+L  E++V +L GYV+EHSAYHH E+SL  T++ +A+++V
Sbjct: 723 CLVDGFKPGQRKVLFSCFKRKLTQEVKVAQLAGYVSEHSAYHHGEASLCGTIINLAQNFV 782

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS NINLL  NGQFGT +QGGKD ASPRY+YT L  I+R +F   D+ +L YL+ED I+V
Sbjct: 783 GSNNINLLSPNGQFGTRLQGGKDAASPRYLYTNLEKITRLIFRPEDDNILNYLSEDNITV 842

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPE+Y+PIIP+VLVNG  GI TGW+ +IP YN  DIIANI++ +N++    +VP+YKGF 
Sbjct: 843 EPEFYVPIIPMVLVNGPEGIGTGWSTTIPNYNVVDIIANIRKLMNNETQTNLVPFYKGFT 902

Query: 360 GTI 362
           G+I
Sbjct: 903 GSI 905


>E9B049_LEIMU (tr|E9B049) DNA topoisomerase 2 OS=Leishmania mexicana (strain
           MHOM/GT/2001/U1103) GN=LMXM_28_2280 PE=3 SV=1
          Length = 1497

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 179/372 (48%), Positives = 259/372 (69%), Gaps = 9/372 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCNGIQK 62
           YG +M M+DQD+DGSHIKGLLINF +   PSLLR+P FL E ITPI++A         + 
Sbjct: 500 YGHLMIMSDQDHDGSHIKGLLINFIHCFWPSLLRVPGFLQEFITPIVKARPKGRGGAGKA 559

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +SF+S P+Y +W K  G+  S+++I+YYKGLG+   EEG+E+F+N++  R  FV +   +
Sbjct: 560 ISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGREYFENIDRHRLSFVEQEQSE 619

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSS----DYRDYTDLSICYKDFLQKEFILYSMASVRR 176
            D I +AF K +  +R+  +  FK++    +  DY    + Y+DF+ KE IL+S+A   R
Sbjct: 620 EDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYNVRQVSYRDFVDKELILFSIADCER 679

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS+IDG KP QRKIL+  FKR L   I+V +L GYV+EHSAYHH E SL  T++ MA+
Sbjct: 680 SIPSVIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSEHSAYHHGEQSLVQTIVGMAQ 739

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+ LL  +GQFGT + GGKDHA+ RYI+T L  ++R +F   D+ +++Y ++DG
Sbjct: 740 DFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMQVARAIFHPADDFVVEYKDDDG 799

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
           +SVEP +Y+P+IP+VLVNG +GI TG++ SIP YNP +II+N++R +  +++  M PWY 
Sbjct: 800 LSVEPFFYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEIISNLERLMQGEEVHKMQPWYF 859

Query: 357 GFKGTIDKSIGG 368
           GF GT+++   G
Sbjct: 860 GFTGTMEEKEPG 871


>H2LXG9_ORYLA (tr|H2LXG9) DNA topoisomerase 2 (Fragment) OS=Oryzias latipes
           GN=LOC101157229 PE=3 SV=1
          Length = 1604

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 188/376 (50%), Positives = 245/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG++M M DQD DGSHIKGLLINFF+   PSLL+   FL + ITPI++A      
Sbjct: 539 LRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HTFLEQFITPIVKA--TKNK 595

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+E+W K   N   W +KYYKGLG+ T +E KE+F ++E  R  F ++  E
Sbjct: 596 QELSFYSLPEFEEWKKQTDNYKSWHVKYYKGLGTSTSKEAKEYFADMERHRITFRYQGAE 655

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK KT +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 656 DDAAITLAFSKKKTDDRKEWLTNF-MEDRRQRRMHGLPEKYLYGTQTKHLSYNDFINKEL 714

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 715 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQA 774

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS NIN+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP +D+
Sbjct: 775 LMMTIVNLAQNFVGSNNINILQPLGQFGTRINGGKDAASPRYIFTMLSPLTKLLFPAVDS 834

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ NI R LN  
Sbjct: 835 NLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQ 894

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKG I
Sbjct: 895 DPLPMLPSYKNFKGVI 910


>A8NS91_BRUMA (tr|A8NS91) DNA topoisomerase 2 OS=Brugia malayi GN=Bm1_08705 PE=3
           SV=1
          Length = 1511

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 176/377 (46%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG+VM MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 553 MKTLRYGKVMVMADQDQDGSHIKGLVINFIHYNWPALVR-RNFVEEFITPIVKA--TKGK 609

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +++SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  +E
Sbjct: 610 EEISFFSLPEYREWLNNTENWKTYRIKYYKGLGTSTSKEAKEYFMDMRRHRIQFKYSGEE 669

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR------------DYTDLSICYKDFLQKEFI 167
           D  A+++AFSK K  ER+  +  + +                D     + +KDF+ KE +
Sbjct: 670 DDQALDMAFSKKKVEERKIWLTNWMAERRNRREDGLTEEYLYDKNTYVVSFKDFVNKELV 729

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+      R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 730 LFLNCDNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 789

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+D+VGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP ID  
Sbjct: 790 MSTIVNLAQDFVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSIDEN 849

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY P+IP VLVNG  GI T W+  +PCYNP++I+ N++  ++  +
Sbjct: 850 VLRFLFEENQKIEPEWYCPVIPTVLVNGAEGIGTAWSTKVPCYNPREIVDNMRALIDGKE 909

Query: 348 LQPMVPWYKGFKGTIDK 364
            +P++PWYK F+GTI++
Sbjct: 910 PKPLIPWYKHFRGTIEQ 926


>Q7PWM2_ANOGA (tr|Q7PWM2) DNA topoisomerase 2 (Fragment) OS=Anopheles gambiae
           GN=AGAP008917 PE=3 SV=4
          Length = 1427

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 188/380 (49%), Positives = 253/380 (66%), Gaps = 16/380 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG+VM M DQD DGSHIKGLLINF +   P LLR+P FL E ITPI++A   NG 
Sbjct: 506 LKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNG- 563

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++LSF+S PE+E+W     NS  + IKYYKGLG+ T +E KE+FQN+E  R  F + +  
Sbjct: 564 EELSFFSLPEFEEWKAETANSHTYNIKYYKGLGTSTSKEAKEYFQNMERHRILFRYEDTG 623

Query: 120 DLDAINIAFSKSKTRERRG-LMLKFKSSDYRDYTDLS-----------ICYKDFLQKEFI 167
           D DAI +AFSK    +R+  L    +   +R    L            I YKDF+  E +
Sbjct: 624 DDDAIMLAFSKKAIEQRKDWLTAHMEECRHRKSVGLQERYLYTKTTKEISYKDFVNLELV 683

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP ++DG KP QRK+LY  FKR+   E++V +L G VAE SAYHH E SL
Sbjct: 684 LFSNSDNVRSIPCMLDGLKPGQRKVLYTCFKRDDKREVKVAQLAGSVAEKSAYHHGEMSL 743

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A++YVGS NINLL   GQFGT + GGKD ASPRYI+T L+ ++R +F  +D+ 
Sbjct: 744 CSTIINLAQNYVGSNNINLLYPGGQFGTRLTGGKDSASPRYIFTMLSALTRHIFHPLDDP 803

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LL+Y  ED   +EP WYLPIIP++L+NG  GI TGW   IP +NP+D+IANI+R LN D+
Sbjct: 804 LLEYQYEDNQRIEPVWYLPIIPMLLINGADGIGTGWATKIPNHNPRDVIANIRRMLNGDE 863

Query: 348 LQPMVPWYKGFKGTIDKSIG 367
            + + PWYK F+G I+ S+G
Sbjct: 864 PKMLTPWYKNFRGVIE-SVG 882


>J9EX29_WUCBA (tr|J9EX29) DNA topoisomerase 2 (Fragment) OS=Wuchereria bancrofti
           GN=WUBG_01928 PE=4 SV=1
          Length = 1042

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 175/377 (46%), Positives = 254/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG++M MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 209 MKTLRYGKIMVMADQDQDGSHIKGLVINFIHYNWPALVR-RNFVEEFITPIVKA--TKGK 265

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +++SF+S PEY +W  +  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  +E
Sbjct: 266 EEISFFSLPEYREWLNDTENWKTYRIKYYKGLGTSTSKEAKEYFMDMRRHRIQFKYSGEE 325

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR------------DYTDLSICYKDFLQKEFI 167
           D  A+++AFSK K  ER+  +  + +                D     + +KDF+ KE +
Sbjct: 326 DDQALDMAFSKKKIEERKIWLTNWMAERRNRREDGLTEEYLYDKNTHVVSFKDFVNKELV 385

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S     R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 386 LFSNCDNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 445

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+D+VGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP ID  
Sbjct: 446 MSTIVNLAQDFVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSIDEN 505

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY P+IP VLVNG  GI T W+  +PCYNP++I+ N++  ++  +
Sbjct: 506 VLRFLFEENQKIEPEWYCPVIPTVLVNGAEGIGTAWSTKVPCYNPREIVDNMRALIDGKE 565

Query: 348 LQPMVPWYKGFKGTIDK 364
            +P++PWYK F+GTI++
Sbjct: 566 PKPLIPWYKHFRGTIEQ 582


>R9NYN7_9BASI (tr|R9NYN7) DNA topoisomerase II OS=Pseudozyma hubeiensis SY62
           GN=PHSY_001366 PE=4 SV=1
          Length = 1523

 Score =  370 bits (949), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 174/366 (47%), Positives = 248/366 (67%), Gaps = 5/366 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC-NG 59
           + S  YG +M M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPI+R   C  G
Sbjct: 614 VNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVR---CRKG 670

Query: 60  IQKLSFYSYPEYEKWW-KNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
            Q LSF++ PEYE W   + G   W IKYYKGLG+   ++ K +F+ +E  +  F    D
Sbjct: 671 KQDLSFFTIPEYETWRDAHNGGKGWHIKYYKGLGTSESQDAKRYFRALEKHKLAFDVTRD 730

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
            D + I++AF+K K  +R+  + +F+   Y D+    I Y DF+ KE IL+SMA   R I
Sbjct: 731 GDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNTDKIPYADFINKELILFSMADNLRSI 790

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRK++Y  F R+  +E++V+ L+G V   +AYHH E++L+ T++ +A+++
Sbjct: 791 PSVVDGLKPGQRKVMYVMFDRKSNSELKVNTLVGNVLGQAAYHHGEAALSMTIVGLAQNF 850

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS N+NLL   GQFGT + GGKD AS RYI+T L  I+R LFP+ D+ LL+YL +DG  
Sbjct: 851 VGSNNVNLLEPRGQFGTRLLGGKDAASGRYIFTALPKIARALFPQADDALLEYLEDDGQK 910

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           VEP WY+P++P VL+NG  GI TGW+ S+P YNP +I+AN++R +  + + PM PW++GF
Sbjct: 911 VEPHWYIPVVPQVLMNGAEGIGTGWSTSVPNYNPHEIVANLRRRMAGEDVVPMKPWFRGF 970

Query: 359 KGTIDK 364
            G +++
Sbjct: 971 TGDVEE 976


>A7IXV6_PBCVN (tr|A7IXV6) Putative uncharacterized protein B781L OS=Paramecium
           bursaria Chlorella virus NY2A GN=B781L PE=3 SV=1
          Length = 1061

 Score =  370 bits (949), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 175/367 (47%), Positives = 252/367 (68%), Gaps = 3/367 (0%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DG+HI GL++NFF+   P+LL IP FL + ITPI+ A     +++
Sbjct: 481 SLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPNLLEIPGFLKKFITPIVVARKGKEVRE 540

Query: 63  LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             F+S P++E + K      W  KY+KGLG+ +  + K++F N++   K F+W +D   +
Sbjct: 541 --FFSLPDFEDFVKTQDMKKWTTKYFKGLGTSSSADAKKYFSNLKSLMKTFMWTSDSG-E 597

Query: 123 AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
            I+ +F+KS+  +R+  M  ++  +  D+    +   DF+ KE IL+S   + R IPS++
Sbjct: 598 LIDRSFNKSRAEDRKEWMTAYEPGNQLDHKKPEVPVPDFIDKELILFSRYDLERSIPSVV 657

Query: 183 DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
           DG KPSQRK++Y AFKR L T+++V +  GYVAEHSAYHH E+SL  T++ +A+DYVGS 
Sbjct: 658 DGFKPSQRKVIYSAFKRNLTTDVKVAQFSGYVAEHSAYHHGEASLQGTIVNLAQDYVGSN 717

Query: 243 NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
           NIN L+  GQFG+ +QGGKDHAS RYIY +LNP +R +F + D+ LLKY+ +DG  +EPE
Sbjct: 718 NINWLLPEGQFGSRLQGGKDHASARYIYMKLNPQTRQVFVDTDDNLLKYMYDDGDKIEPE 777

Query: 303 WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +Y+P+IP +LVNG SGI TGW+ +IP YNPKDI+ N+KR ++ + L  M PWYKGFKG I
Sbjct: 778 YYVPVIPSILVNGSSGIGTGWSTNIPSYNPKDIVDNVKRLISGEDLVEMKPWYKGFKGKI 837

Query: 363 DKSIGGM 369
            ++  G+
Sbjct: 838 METSPGV 844


>B7P0P1_IXOSC (tr|B7P0P1) DNA topoisomerase 2 OS=Ixodes scapularis
           GN=IscW_ISCW016225 PE=3 SV=1
          Length = 1582

 Score =  370 bits (949), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 183/379 (48%), Positives = 258/379 (68%), Gaps = 20/379 (5%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YGR+M M DQD DGSHIKGL+INF +   PSLL++P FL E ITPI++A    G 
Sbjct: 534 LKALRYGRLMIMTDQDQDGSHIKGLVINFIHHNWPSLLKLP-FLEEFITPIVKA--SKGK 590

Query: 61  QKLSFYSYPEYEKW---WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
            ++SFYS PE+E+W     +W    W++KYYKGLG+ T +E KE+F ++   R  F ++ 
Sbjct: 591 NEISFYSLPEFEEWKTATDDWQR--WKVKYYKGLGTSTGKEAKEYFSDMLRHRIKFKYQG 648

Query: 118 DEDLDAINIAFSKSKTRER----RGLMLKFKSSDYRDYTDL--------SICYKDFLQKE 165
            ED  AI +AFSK    +R    RG M + K        ++        +I Y+DF+ KE
Sbjct: 649 GEDDRAIELAFSKKLADQRKDWLRGGMEERKQRRELGLPEIYLYGKETKNITYEDFVNKE 708

Query: 166 FILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDES 225
            IL+S     R IPSL+DG KP QRK+LY  FKR    EI+V +L G VAEHSAYHH E 
Sbjct: 709 LILFSNMDNERSIPSLVDGLKPGQRKVLYTCFKRNDKREIKVAQLAGSVAEHSAYHHGEM 768

Query: 226 SLATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEID 285
           SL +T++ +A+D+VGS NINLL+  GQFGT +QGGKD ASPRYI+T L+P++R + P +D
Sbjct: 769 SLMSTIIGLAQDFVGSNNINLLLPIGQFGTRLQGGKDAASPRYIFTMLSPLARLIVPALD 828

Query: 286 NKLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLND 345
           + +L +L +D   +EPE+Y+PI+P+VLVNG  GI TGW+  +P Y+P++++AN++R +  
Sbjct: 829 DPVLNHLYDDNQKIEPEFYMPILPMVLVNGAEGIGTGWSTKVPNYDPREVVANLRRMIAG 888

Query: 346 DKLQPMVPWYKGFKGTIDK 364
           D+ +PM PW+K FKGT+D+
Sbjct: 889 DEPKPMKPWFKNFKGTVDQ 907


>A7K9G1_9PHYC (tr|A7K9G1) Putative uncharacterized protein Z551L OS=Acanthocystis
           turfacea Chlorella virus 1 GN=Z551L PE=3 SV=1
          Length = 1058

 Score =  369 bits (948), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 176/368 (47%), Positives = 249/368 (67%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG V+ MADQD DGSHI GL++NFF+   PSLL IP FL   +TPI+ A    G + 
Sbjct: 475 SLRYGSVIIMADQDVDGSHIAGLVLNFFHAQFPSLLEIPGFLKRFVTPIVVA--KKGTKM 532

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + FYS P++E+W     + S W+ KYYKGLG+    + K +F N++   K   W +D   
Sbjct: 533 VEFYSIPDFEEWKAATSDVSTWKTKYYKGLGTSDANDAKRYFNNLKALVKTLTW-SDNAA 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           ++I+ +F+KS+  ER+  +L F+  +  D     I  +DF+ K+ IL+S   V R IPS+
Sbjct: 592 ESIDKSFNKSRADERKTWLLDFEPGNQLDQKLTKIPVEDFINKDLILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ A KR L  EI+V +  GY +E++ YHH E+SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFSALKRNLVQEIKVAQFAGYTSENAGYHHGEASLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NINLL+  GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EP
Sbjct: 712 NNINLLLPRGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDRIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P IP +LVNG SGI TG++ +IP YNPKDI+ N+KR +N++ + PM PWY+GFKG 
Sbjct: 772 EYYVPTIPFLLVNGSSGIGTGFSTNIPAYNPKDIVDNVKRLINNETMLPMTPWYRGFKGD 831

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 832 IKETSPGV 839


>E0VS84_PEDHC (tr|E0VS84) DNA topoisomerase 2 OS=Pediculus humanus subsp.
           corporis GN=Phum_PHUM413330 PE=3 SV=1
          Length = 1223

 Score =  369 bits (948), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 186/376 (49%), Positives = 250/376 (66%), Gaps = 16/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGL+INF +   PSLLR+P FL E ITPI++A    G 
Sbjct: 532 LKTLRYGKLMIMTDQDQDGSHIKGLIINFIHHNWPSLLRLP-FLEEFITPIVKA--TKGK 588

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++LSFYS PE+E W K   N+  +R KYYKGLG+ T +E KE+FQ+++  R  F +    
Sbjct: 589 EELSFYSLPEFEDWKKATENAHLYRTKYYKGLGTSTSKEAKEYFQDMKRHRILFNYDGPS 648

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR------------DYTDLSICYKDFLQKEFI 167
           D   IN+AFSK    +R+  +  +     R                +++ Y DF+ KE +
Sbjct: 649 DDYCINMAFSKKCADQRKEWLTSWMEDCKRRRETGLGEAFLYQKNTIAVSYSDFINKELV 708

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S     R IPS++DG KP QRK+L+   KR    EI+V +L G VAEHSAYHH E+SL
Sbjct: 709 LFSNLDNERSIPSMVDGLKPGQRKVLFTCLKRNDKKEIKVAQLAGSVAEHSAYHHGEASL 768

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A++YVGS N+NLL+  GQFGT +QGGKD ASPRYI+T LNP++R +F   D+ 
Sbjct: 769 MGTIINLAQNYVGSNNLNLLLPIGQFGTRLQGGKDAASPRYIFTLLNPLTRLIFHVHDDP 828

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   +EPEWY+PIIP+VLVNG  GI TGW   IP +NP++I+ NIKR L+ D+
Sbjct: 829 LLKYNKDDNQKIEPEWYIPIIPMVLVNGADGIGTGWMTKIPNHNPREIVQNIKRMLDGDE 888

Query: 348 LQPMVPWYKGFKGTID 363
             PM PWYKGFKG I+
Sbjct: 889 PLPMKPWYKGFKGDIE 904


>K9IC41_AGABB (tr|K9IC41) DNA topoisomerase 2 OS=Agaricus bisporus var. bisporus
           (strain H97 / ATCC MYA-4626 / FGSC 10389)
           GN=AGABI2DRAFT_197775 PE=3 SV=1
          Length = 1551

 Score =  369 bits (948), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 175/363 (48%), Positives = 245/363 (67%), Gaps = 3/363 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YGR+M MADQD+DGSHIKGLLINFF    PSLL++P FL E +TPI+R     G 
Sbjct: 599 VSSLRYGRLMIMADQDHDGSHIKGLLINFFDHFYPSLLKLPEFLVEFVTPIVRII--KGK 656

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +  F++ PEYEKW     ++  W  KYYKGLG+    + +++F ++      F    + 
Sbjct: 657 HRRDFFTLPEYEKWLLEAPDAHKWESKYYKGLGTSNDADARDYFSHMAKHMIPFAPTQNG 716

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D I++AFSK K  +R+  + +F+   + D+    I Y +F+ KE I +SMA   R IP
Sbjct: 717 DRDLIDLAFSKKKADDRKEWLRQFRPGTFLDHNLEEIPYSEFINKELICFSMADNIRSIP 776

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            + DG KP QRK+++  FKR+L  EI+V +L+GY++EH+AYHH E+SLA T++ +A+D+V
Sbjct: 777 CVADGLKPGQRKVIWSCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAQTIINLAQDFV 836

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS N+NLL  NGQ+GT  QGGKDHASPRYI+TE   ++R ++   D+ LLK   ED   +
Sbjct: 837 GSNNVNLLSPNGQYGTRDQGGKDHASPRYIFTEPKAMTRVVYHPDDDPLLKGQREDNQWI 896

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPE+YLP+IPLVL NG  GI TGW+ +IPC+NP  I+ NI+R +N ++   M PW++GFK
Sbjct: 897 EPEFYLPVIPLVLCNGAEGIGTGWSTNIPCFNPAVIVENIRRLMNGEEQVAMKPWWRGFK 956

Query: 360 GTI 362
           G I
Sbjct: 957 GEI 959


>G3P0Y7_GASAC (tr|G3P0Y7) DNA topoisomerase 2 (Fragment) OS=Gasterosteus
           aculeatus GN=TOP2A PE=3 SV=1
          Length = 1569

 Score =  369 bits (947), Expect = e-99,   Method: Compositional matrix adjust.
 Identities = 192/378 (50%), Positives = 252/378 (66%), Gaps = 17/378 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A H    
Sbjct: 528 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRH-NFLEEFITPIIKATHKKS- 585

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PEY  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 586 -QLSFYSIPEYNAWKQSQPNQKAWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYSGPE 644

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI++AFSK K  ER+  +  F  +  +        DY    +  S+ Y DF+ KE +
Sbjct: 645 DDEAISLAFSKKKVDERKEWLTNFMVNRRQRRAHNLPEDYLYSQSTKSLSYNDFVNKELV 704

Query: 168 LYSMASVRRCIPSLID-GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           L+S +   R IP L+D G KP QRK+L+  FKR    E++V +L G VAE SAYHH E S
Sbjct: 705 LFSNSDNERSIPCLVDAGLKPGQRKVLFSCFKRNDKREVKVAQLAGSVAEMSAYHHGEIS 764

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 765 LMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPAVDD 824

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLKY  +D   VEPEWYLPIIP VLVNG  GI TGW   IP YN ++I++NI R L+ D
Sbjct: 825 NLLKYNVDDNQRVEPEWYLPIIPTVLVNGAEGIGTGWASKIPNYNIREIVSNIHRLLSGD 884

Query: 347 KLQPMVPWYKGFKGTIDK 364
           +  PM+P YKGF+GTID+
Sbjct: 885 EPLPMLPNYKGFRGTIDQ 902


>C5DMF0_LACTC (tr|C5DMF0) DNA topoisomerase 2 OS=Lachancea thermotolerans (strain
           ATCC 56472 / CBS 6340 / NRRL Y-8284) GN=KLTH0G08338g
           PE=3 SV=1
          Length = 1436

 Score =  369 bits (947), Expect = e-99,   Method: Compositional matrix adjust.
 Identities = 180/370 (48%), Positives = 254/370 (68%), Gaps = 6/370 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD+DGSHIKGL+INF     P LL IP FL E ITPI++       +
Sbjct: 511 KSLRYGHIMIMTDQDHDGSHIKGLIINFLESSFPGLLDIPGFLIEFITPIVKVTITRPKR 570

Query: 62  K-LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
             +SFY+ P+YE+W +   +   W+ KYYKGLG+ + +E +E+F +++   K F     E
Sbjct: 571 DVISFYNMPDYEEWREKESHKYSWKQKYYKGLGTSSLQEAREYFSDLDTHLKKFHALEGE 630

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYT--DLSICYKDFLQKEFILYSMASVRRC 177
           D   I++AFSK K  +R+  + +++  +  D T  ++ IC  DF+ KE IL+S+A   R 
Sbjct: 631 DSQLIDLAFSKKKADDRKEWLRQYEPGNTLDPTLSEIPIC--DFINKELILFSLADNVRS 688

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS++DG KP QRK+LY  FKR+L +EI+V +LIGYV+EH++YHH E SLA T++ MA+D
Sbjct: 689 IPSVLDGFKPGQRKVLYSCFKRKLKSEIKVAQLIGYVSEHTSYHHGEQSLAQTIVGMAQD 748

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           YVGS NI LL  NG FGT   GGKD A+PRYI+TELN I+  +F  +DN LL YL ED  
Sbjct: 749 YVGSNNIYLLKPNGAFGTRAAGGKDSAAPRYIFTELNNITPNIFNPLDNPLLTYLQEDDQ 808

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
           ++EP+WYLP+IP++LVNG  GI TGW+ +IPC+NP +I+ NIK+ +N + +  M P+Y+G
Sbjct: 809 TIEPQWYLPVIPMILVNGAEGIGTGWSTNIPCFNPLEIVQNIKKLMNGEPMDDMAPFYRG 868

Query: 358 FKGTIDKSIG 367
           ++G + K  G
Sbjct: 869 WEGRLQKIDG 878


>L7JVE8_TRAHO (tr|L7JVE8) DNA topoisomerase 2 (Fragment) OS=Trachipleistophora
           hominis GN=THOM_1646 PE=3 SV=1
          Length = 1474

 Score =  369 bits (947), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 186/393 (47%), Positives = 250/393 (63%), Gaps = 27/393 (6%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           ES  YG V+ M DQD+DGSHIKGL+INFF    PSLLRI  FL E ITPI+R     G +
Sbjct: 523 ESLRYGHVIIMTDQDHDGSHIKGLIINFFDHFFPSLLRIEGFLKEFITPIVRVTKTKGSR 582

Query: 62  K-------------------------LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFT 95
                                     + F++ PEYE W  +  +  +W +KYYKGLG+ T
Sbjct: 583 TSRSNSEDDSDEHTNTPASSDPVGTVIDFFTIPEYEDWKNSTPDIKNWTVKYYKGLGTST 642

Query: 96  HEEGKEFFQNVEIQRKYFVWRNDEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLS 155
            ++ K++F N+E   K F     ED   I++AF+K K  +R+  +       + D++   
Sbjct: 643 SKDAKQYFSNLEKHVKSFTLLTTEDQSLIDLAFNKKKADDRKLWLKNCVPGTFLDHSAHK 702

Query: 156 ICYKDFLQKEFILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVA 215
           I  +DF+ KE IL+SMA   R IPS++DG KP QRK++Y  FKR L +EI+V +L+GYVA
Sbjct: 703 IPIRDFINKELILFSMADNVRSIPSVVDGFKPGQRKVMYCCFKRNLKSEIKVAQLVGYVA 762

Query: 216 EHSAYHHDESSLATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNP 275
           EHSAYHH E SL  T++++A D+VGS NINLLM  GQFGT +QGGKD AS RYI+T L  
Sbjct: 763 EHSAYHHGEVSLQQTIIKLAHDFVGSNNINLLMPEGQFGTRLQGGKDAASARYIFTNLAS 822

Query: 276 ISRFLFPEIDNKLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDI 335
           I+R +F E D+ LL Y+ ED + +EP +Y+PI+P+VLVNG  GI TGW   IP Y+  +I
Sbjct: 823 ITRKIFVESDDALLNYITEDNMKIEPSFYVPIVPMVLVNGADGIGTGWLTKIPNYDLLEI 882

Query: 336 IANIKRFLNDDKLQPMVPWYKGFKGTIDKSIGG 368
           I NIK  L+D ++  MVP+Y+GFKG I+  +GG
Sbjct: 883 IDNIKLLLDDQEMNTMVPFYRGFKGEIE-DLGG 914


>I2FWY2_USTH4 (tr|I2FWY2) DNA topoisomerase 2 OS=Ustilago hordei (strain
           Uh4875-4) GN=UHOR_05386 PE=3 SV=1
          Length = 1503

 Score =  369 bits (946), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 173/365 (47%), Positives = 249/365 (68%), Gaps = 3/365 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGL+INF     PSLL++P FL E ITPI++     G 
Sbjct: 608 VSSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKLPNFLVEFITPIVKC--SKGK 665

Query: 61  QKLSFYSYPEYEKWWK-NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++LSF++ PEY  W + N     WRIKYYKGLG+   ++ K++F+ ++     F    D 
Sbjct: 666 KELSFFTIPEYMTWKEANSNGKGWRIKYYKGLGTSDSQDAKKYFRAMDKHMLPFDTTKDG 725

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D + I++AF+K K  +R+  + +F+   Y D+    I Y DF+ KE IL+SMA   R IP
Sbjct: 726 DRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNIDKIPYADFINKELILFSMADNMRSIP 785

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S +DG KP QRK+++G F R+   EI+V +L+G+V+  +AYHH E SL  T++ +A+++V
Sbjct: 786 SAVDGLKPGQRKVIFGTFNRKGDGEIKVAQLVGHVSGTTAYHHGEQSLTMTIVGLAQNFV 845

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS N+NLL   GQFGT + GGKD AS RYI+T L  I+R LFP+ D+ LL+YL++DG S+
Sbjct: 846 GSNNVNLLEPRGQFGTRLLGGKDAASARYIFTALPKITRALFPQNDDALLEYLDDDGQSI 905

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EP+WY+P++P VL+NG  GI TGW+  +P YNP DI+AN++R +  + + PM PWY+GF 
Sbjct: 906 EPQWYMPVVPQVLLNGAEGIGTGWSTFVPNYNPHDIVANLRRRMAGEDVVPMKPWYRGFT 965

Query: 360 GTIDK 364
           G I++
Sbjct: 966 GDIEE 970


>A3AAF2_ORYSJ (tr|A3AAF2) DNA topoisomerase 2 OS=Oryza sativa subsp. japonica
           GN=OsJ_08043 PE=3 SV=1
          Length = 1487

 Score =  369 bits (946), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 170/305 (55%), Positives = 226/305 (74%), Gaps = 2/305 (0%)

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           L FYS PEYE+W ++ G   S W IKYYKGLG+ T  EG+++FQ++   +K FVW+ND+D
Sbjct: 549 LPFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKNDQD 608

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            + I +AFSK +  +R+  +  F+S  + D     I Y DF+ KE I +SMA + R IPS
Sbjct: 609 DNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRSIPS 668

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRKIL+ +FKR L  EI+V +  GYV+EHSAYHH E SLA+T+  MA+D+VG
Sbjct: 669 MVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQDFVG 728

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL  NGQFGT  QGGKD AS RYI+T L+PI+R +FP+ D+ LL YL+EDG S+E
Sbjct: 729 SNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQSIE 788

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P WY+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LND+ ++PM PWY+GFKG
Sbjct: 789 PTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRGFKG 848

Query: 361 TIDKS 365
           +I K+
Sbjct: 849 SIQKT 853


>A2X8M2_ORYSI (tr|A2X8M2) DNA topoisomerase 2 OS=Oryza sativa subsp. indica
           GN=OsI_08583 PE=3 SV=1
          Length = 1486

 Score =  369 bits (946), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 170/305 (55%), Positives = 226/305 (74%), Gaps = 2/305 (0%)

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           L FYS PEYE+W ++ G   S W IKYYKGLG+ T  EG+++FQ++   +K FVW+ND+D
Sbjct: 549 LPFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKNDQD 608

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            + I +AFSK +  +R+  +  F+S  + D     I Y DF+ KE I +SMA + R IPS
Sbjct: 609 DNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRSIPS 668

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           ++DG KP QRKIL+ +FKR L  EI+V +  GYV+EHSAYHH E SLA+T+  MA+D+VG
Sbjct: 669 MVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQDFVG 728

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL  NGQFGT  QGGKD AS RYI+T L+PI+R +FP+ D+ LL YL+EDG S+E
Sbjct: 729 SNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQSIE 788

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P WY+PI+P+VLVNG  GI TGW+  IP YNP+DI+AN++R LND+ ++PM PWY+GFKG
Sbjct: 789 PTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRGFKG 848

Query: 361 TIDKS 365
           +I K+
Sbjct: 849 SIQKT 853


>D3B7U7_POLPA (tr|D3B7U7) DNA topoisomerase 2 OS=Polysphondylium pallidum GN=top2
            PE=3 SV=1
          Length = 1524

 Score =  369 bits (946), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 182/369 (49%), Positives = 251/369 (68%), Gaps = 5/369 (1%)

Query: 1    MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
            ++S  YG +M M DQD+DGSHIKGLL+NF +   PSLLRI  FL E +TPII+A    G 
Sbjct: 638  VKSLRYGHLMIMTDQDHDGSHIKGLLLNFIHHFWPSLLRIEGFLVEFVTPIIKA--TKGN 695

Query: 61   QKLSFYSYPEYEKWWK-NWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            + ++FY+ PEY  W + N     + IKYYKGLG+ T EE KE+F  +   +  F + N  
Sbjct: 696  KTIAFYTIPEYLAWREANNNGKGYEIKYYKGLGTSTEEEAKEYFSQLVNHKIDFEYDNGA 755

Query: 120  DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-YTDLSICYKDFLQKEFILYSMASVRRCI 178
            D DAI+ AF+K +  +R+  M ++    Y D Y    +   DF+ KE IL+S+A   R I
Sbjct: 756  D-DAIDKAFNKKRANDRKTWMDQYTPGAYLDQYGIKKVKITDFIDKELILFSIADCERSI 814

Query: 179  PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
            PS++DG K SQRKIL+  FKR L  EI+V +LIGYV+E SAYHH + SLA+ ++ +A+ Y
Sbjct: 815  PSIVDGFKTSQRKILFSCFKRNLKKEIKVAQLIGYVSEQSAYHHGDQSLASAIIGLAQTY 874

Query: 239  VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
            VG+ NIN+L   G FG+ + GGKD ++PRYI T L  I+R LFPE D+ LL +L +DG  
Sbjct: 875  VGANNINVLYPGGGFGSRLAGGKDSSAPRYINTRLEEIARTLFPEEDHALLSHLTDDGKR 934

Query: 299  VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
            V+P+WY+P+IP++LVNG  GI TGW+ +IP YNP+D+I N+K  +   +L+P+VPWY+GF
Sbjct: 935  VQPKWYIPVIPMILVNGSKGIGTGWSSTIPNYNPRDLIENMKLLIEGKELKPIVPWYRGF 994

Query: 359  KGTIDKSIG 367
            KGTI+   G
Sbjct: 995  KGTIELQTG 1003


>E9BJW5_LEIDB (tr|E9BJW5) DNA topoisomerase 2 OS=Leishmania donovani (strain
           BPK282A1) GN=LDBPK_282450 PE=3 SV=1
          Length = 1498

 Score =  368 bits (945), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 178/372 (47%), Positives = 259/372 (69%), Gaps = 9/372 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCNGIQK 62
           YG +M M+DQD+DGSHIKGLLINF +   P+LLR+P FL + ITPI++A         + 
Sbjct: 500 YGHLMIMSDQDHDGSHIKGLLINFIHCFWPNLLRVPGFLQQFITPIVKARPKGRGGAGKA 559

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +SF+S P+Y +W K  G+  S+++I+YYKGLG+   EEG+E+F+N++  R  FV +   +
Sbjct: 560 ISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGREYFENIDRHRLNFVEQEQSE 619

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSS----DYRDYTDLSICYKDFLQKEFILYSMASVRR 176
            D I +AF K +  +R+  +  FK++    +  DY    + Y+DF+ KE IL+S+A   R
Sbjct: 620 EDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYNVRQVSYRDFVDKELILFSIADCER 679

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS+IDG KP QRKIL+  FKR L   I+V +L GYV+EHSAYHH E SL  T++ MA+
Sbjct: 680 SIPSVIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSEHSAYHHGEQSLVQTIVGMAQ 739

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+ LL  +GQFGT + GGKDHA+ RYI+T L  +SR +F   D+ +++Y ++DG
Sbjct: 740 DFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMQVSRAIFHPADDFVVEYKDDDG 799

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
           +SVEP +Y+P+IP+VLVNG +GI TG++ SIP YNP +II+N++R +  +++  M PWY 
Sbjct: 800 LSVEPFFYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEIISNLERLMRGEEVHKMQPWYF 859

Query: 357 GFKGTIDKSIGG 368
           GF GT+++   G
Sbjct: 860 GFTGTMEEKEPG 871


>Q4Z0B9_PLABA (tr|Q4Z0B9) DNA topoisomerase 2 (Fragment) OS=Plasmodium berghei
           (strain Anka) GN=PB000671.01.0 PE=3 SV=1
          Length = 1092

 Score =  368 bits (945), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 178/358 (49%), Positives = 248/358 (69%), Gaps = 3/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M + DQDYDGSHIKGLLIN  +   PSLL+   FL E +TPI++    N  Q+LSF
Sbjct: 575 YGSLM-ITDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLCEFVTPIVKVQKGN--QELSF 631

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  EYE+W +N     W+IKYYKGLG+ T +E K++F +++  +  F+W  D D D+I+
Sbjct: 632 FTIAEYEQWKENTNLVGWKIKYYKGLGTSTDKEFKQYFSDIQSHKIVFLWTGDRDGDSID 691

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AFSK +  +R+  +  F    Y D+ +  + Y DF+ KE I YS     R IP+++DG 
Sbjct: 692 MAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGW 751

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+LYG FKR L  E +V +L+GY+AEHSAYHH ESSL  T++ MA+ +VGS NIN
Sbjct: 752 KPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNIN 811

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
            L   GQFG+  +GGKD ++ RYI+T+L   +R +F E D+ +LKYLNE+G  +EP++Y+
Sbjct: 812 FLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYI 871

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           P+IP +LVNG  GI TG++  IP YN KDII NIK++++ + L PMVPWYK FKG I+
Sbjct: 872 PVIPTILVNGCEGIGTGYSSFIPNYNYKDIINNIKKYIDKEPLVPMVPWYKDFKGRIE 929


>M1GWJ2_9PHYC (tr|M1GWJ2) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus Can0610SP GN=Can0610SP_665L PE=3 SV=1
          Length = 1058

 Score =  368 bits (945), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 176/368 (47%), Positives = 248/368 (67%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M+DQD DGSHI GL++NFF+   PSLL IP FL   +TPI+ A    G + 
Sbjct: 475 SLRYGSVMIMSDQDVDGSHIAGLVLNFFHAQFPSLLEIPGFLKRFVTPIVVA--KKGTKM 532

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + FYS P++E+W     + S W+ KY+KGLG+    + K +F N+++  K   W +D+  
Sbjct: 533 VEFYSIPDFEEWKAATPDVSTWKTKYFKGLGTSDANDAKRYFNNLKVLVKTLTW-SDDAA 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           ++I+ +F+KS+  ER+  +L FK  +  D     I  +DF+ K+ IL+S   V R IPS+
Sbjct: 592 ESIDKSFNKSRADERKTWLLDFKPGNQLDQKLTKIPVEDFINKDLILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  EI+V +  GYV+EH+ YHH E+SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFSAFKRNLVQEIKVAQFAGYVSEHAGYHHGEASLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NINLL   GQFG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EP
Sbjct: 712 NNINLLAPKGQFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDRIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P IP +LVNG +GI TG++ +IP YNPK+I+ N+KR +N   +  M PWYK FKG 
Sbjct: 772 EYYVPTIPFLLVNGANGIGTGFSTNIPSYNPKEIVNNVKRLINGKPMTEMTPWYKNFKGD 831

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 832 IKETSPGV 839


>Q4P8R2_USTMA (tr|Q4P8R2) DNA topoisomerase 2 OS=Ustilago maydis (strain 521 /
           FGSC 9021) GN=UM03501.1 PE=3 SV=1
          Length = 1518

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 175/364 (48%), Positives = 244/364 (67%), Gaps = 5/364 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC-NGIQ 61
           S  YG +M M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPI+R   C  G Q
Sbjct: 613 SLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVR---CRKGKQ 669

Query: 62  KLSFYSYPEYEKWW-KNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
            +SF++ PEYE W   + G   W IKYYKGLG+   ++ K +F+ +E  +  F    D D
Sbjct: 670 DISFFTIPEYETWRDAHNGGKGWHIKYYKGLGTSESQDAKRYFRALEKHKLAFDVTRDGD 729

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            + I++AF+K K  +R+  + +F+   Y D+    I Y DF+ KE IL+SMA   R IPS
Sbjct: 730 RELIDLAFNKKKADDRKEWLRQFRPGTYLDHNTDRIPYADFINKELILFSMADNLRSIPS 789

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
            IDG KP QRK++Y  F R+  +E++V+ L+G V   +AYHH E++L+ T++ +A+++VG
Sbjct: 790 AIDGLKPGQRKVMYVMFDRKSNSELKVNTLVGNVLGQAAYHHGEAALSMTIVGLAQNFVG 849

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S N+NLL   GQFGT + GGKD AS RYI+T L  I+R LFP  D+ LL YL +DG  VE
Sbjct: 850 SNNVNLLEPRGQFGTRLLGGKDAASGRYIFTALPKIARALFPATDDALLDYLEDDGQKVE 909

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           P WY+P++P VL+NG  GI TGW+ S+P YNP +I+AN++R +  + + PM PWY+GF G
Sbjct: 910 PHWYIPVVPQVLLNGAEGIGTGWSTSVPNYNPHEIVANLRRRMAGEDVVPMKPWYRGFNG 969

Query: 361 TIDK 364
            +++
Sbjct: 970 DVEE 973


>K5Y6A9_AGABU (tr|K5Y6A9) DNA topoisomerase 2 OS=Agaricus bisporus var. burnettii
           (strain JB137-S8 / ATCC MYA-4627 / FGSC 10392)
           GN=AGABI1DRAFT_117173 PE=3 SV=1
          Length = 1549

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 175/363 (48%), Positives = 244/363 (67%), Gaps = 3/363 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YGR+M MADQD+DGSHIKGLLINFF    PSLL++P FL E +TPI+R     G 
Sbjct: 597 VSSLRYGRLMIMADQDHDGSHIKGLLINFFDHFYPSLLKLPEFLVEFVTPIVRII--KGK 654

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +  F++ PEYEKW     ++  W  KYYKGLG+    + +++F ++      F      
Sbjct: 655 HRRDFFTLPEYEKWLLEAPDAHKWESKYYKGLGTSNDADARDYFSHMAKHMIPFAPTQHG 714

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D D I++AFSK K  +R+  + +F+   + D+    I Y +F+ KE I +SMA   R IP
Sbjct: 715 DRDLIDLAFSKKKADDRKEWLRQFRPGTFLDHNLEEIPYSEFINKELICFSMADNIRSIP 774

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            + DG KP QRK+++  FKR+L  EI+V +L+GY++EH+AYHH E+SLA T++ +A+D+V
Sbjct: 775 CVADGLKPGQRKVIWSCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAQTIINLAQDFV 834

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS N+NLL  NGQ+GT  QGGKDHASPRYI+TE   ++R ++   D+ LLK   ED   +
Sbjct: 835 GSNNVNLLSPNGQYGTRDQGGKDHASPRYIFTEPKAMTRVVYHPDDDPLLKGQREDNQWI 894

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPE+YLP+IPLVL NG  GI TGW+ +IPC+NP  I+ NI+R +N ++   M PW++GFK
Sbjct: 895 EPEFYLPVIPLVLCNGAEGIGTGWSTNIPCFNPAVIVENIRRLMNGEEQVAMKPWWRGFK 954

Query: 360 GTI 362
           G I
Sbjct: 955 GEI 957


>K0KT01_WICCF (tr|K0KT01) DNA topoisomerase 2 OS=Wickerhamomyces ciferrii (strain
           F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 /
           NRRL Y-1031) GN=TOP2 PE=3 SV=1
          Length = 1503

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 182/366 (49%), Positives = 244/366 (66%), Gaps = 2/366 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YGR+M M DQD DGSHIKGL+INF     P LL IP FL E ITPI++       
Sbjct: 533 LKSLRYGRIMIMTDQDTDGSHIKGLIINFLETSFPGLLNIPGFLLEFITPIVKVNITKPR 592

Query: 61  QK-LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           ++ L+FY+ PEYE W +N  +   W  KYYKGLG+ + EEG+E+F ++E   K F    +
Sbjct: 593 RETLAFYNMPEYESWIENESHQYTWTHKYYKGLGTSSQEEGREYFSDLEKHLKTFNPLEE 652

Query: 119 EDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCI 178
            D   I++AFSK K   R+  +  F    + D     I   +F+ KE IL+SMA   R I
Sbjct: 653 NDKGLIDLAFSKKKADHRKEWLRGFVPGTHLDIDLNEIPISEFINKELILFSMADNIRSI 712

Query: 179 PSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDY 238
           PS++DG KP QRKILYG+FKR L +EI+V +L GY++EH+ YHH E SL TT++ +A+D+
Sbjct: 713 PSVLDGFKPGQRKILYGSFKRNLKSEIKVAQLAGYISEHTGYHHGEQSLITTIVGLAQDF 772

Query: 239 VGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGIS 298
           VGS NINLL+  G FGT   GGKD ++ RYIYTEL  I+R +F + D+ L  Y  +DG +
Sbjct: 773 VGSNNINLLLPKGSFGTRNMGGKDASAARYIYTELATITRKIFNQTDDALYTYEQDDGEN 832

Query: 299 VEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGF 358
           VEP WYLPIIP+VLVNG  GI TGW+ ++P +NP D++ N+KR +N+ +L  M PWYKG+
Sbjct: 833 VEPTWYLPIIPMVLVNGAEGIGTGWSTNVPQFNPADLVENMKRLMNNQELLEMEPWYKGW 892

Query: 359 KGTIDK 364
            G I K
Sbjct: 893 DGQIQK 898


>I1C6D9_RHIO9 (tr|I1C6D9) DNA topoisomerase 2 OS=Rhizopus delemar (strain RA 99-880
            / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) GN=RO3G_08724
            PE=3 SV=1
          Length = 1330

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 174/364 (47%), Positives = 249/364 (68%), Gaps = 1/364 (0%)

Query: 1    MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
            ++   YGR+M M DQD+DGSHIKGLLINF   + PSLL IP FL E ITPII+  H    
Sbjct: 660  VDELRYGRLMIMTDQDHDGSHIKGLLINFIDTMFPSLLDIPGFLLEFITPIIKCTHKRTK 719

Query: 61   QKLSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            + +SF++ PEYE W  ++   S+W  KY+KGLG+      +E+F N+ + +K F   + E
Sbjct: 720  EVISFFTIPEYESWALEHNKKSEWEPKYFKGLGTSDKTAAREYFSNLPVHQKEFQTMDTE 779

Query: 120  DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
            D   I++AF+K K  +R+  +++++   Y D++   I   DF+ +E +L+SMA   R IP
Sbjct: 780  DRQLIDMAFNKKKASDRKEWLVQYEPGIYIDHSVNKIKISDFVNRELLLFSMADNIRSIP 839

Query: 180  SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
            S++DG KP+QRK+LYG  KR   TE++V +L  YVA  + YHH E+S+A+T++ MA+++V
Sbjct: 840  SMVDGFKPAQRKVLYGCIKRNKNTEVKVAQLANYVAGVTQYHHGEASVASTIINMAQEFV 899

Query: 240  GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
            GS NIN+L+ +GQFG+  +G K  ASPRY++T L  I+R +F   D+ LL YL E+   +
Sbjct: 900  GSNNINVLVPSGQFGSRHEGSKSAASPRYLFTRLTKIARIIFHPNDDALLNYLVEENTLI 959

Query: 300  EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
            EP WY+PIIP+VLVNG  GI TGW+ +IP YNPKDII NI R +N +++  M PWY+GFK
Sbjct: 960  EPSWYMPIIPMVLVNGADGIGTGWSTAIPNYNPKDIIENIFRLMNGEEIVTMKPWYRGFK 1019

Query: 360  GTID 363
            G I+
Sbjct: 1020 GEIN 1023


>J0DYM4_LOALO (tr|J0DYM4) DNA topoisomerase 2 OS=Loa loa GN=LOAG_17616 PE=3 SV=1
          Length = 1569

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 179/377 (47%), Positives = 255/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG++M MADQD DGSHIKGL+INF +   P L+R   F+ E ITPI++A    G 
Sbjct: 577 MKTLRYGKIMVMADQDQDGSHIKGLVINFIHYNWPVLIR-RNFVEEFITPIVKA--TKGK 633

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +  SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  +E
Sbjct: 634 ESFSFFSLPEYAEWRNNTENWKTYRIKYYKGLGTSTSKEAKEYFTDMVRHRIRFQYSGEE 693

Query: 120 DLDAINIAFSKSKTRERR----GLMLKFKSSDYRDYTD--------LSICYKDFLQKEFI 167
           D +++++AFSK K  +R+      M + K+   +  T+         ++ +KDF+ KE +
Sbjct: 694 DDNSLDMAFSKKKIEDRKVWLTNWMAEKKARREQGLTEEYLYNKDTRAVSFKDFVNKELV 753

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S A   R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 754 LFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 813

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP++R LFP +D  
Sbjct: 814 MSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTRALFPIVDEN 873

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  IP YNP++I+ N++R +  ++
Sbjct: 874 VLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKIPNYNPREIVDNMRRLIRGEE 933

Query: 348 LQPMVPWYKGFKGTIDK 364
            + + PW+K F+GTI+K
Sbjct: 934 PKSLTPWFKNFRGTIEK 950


>M1HTB7_9PHYC (tr|M1HTB7) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus CZ-2 GN=CZ-2_616R PE=3 SV=1
          Length = 1059

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 184/368 (50%), Positives = 247/368 (67%), Gaps = 5/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I +
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDINE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W KN  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKKNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLNFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMAN-GQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
            N   L+   GQFG+ I GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+E
Sbjct: 712 NNNMNLLLPNGQFGSRILGGKDSASARYIFTKLSPVTRQVFNQTDDVLLKYLEDDGSSIE 771

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR +   ++ PM PWYKGF G
Sbjct: 772 PEWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLIAGKEMVPMTPWYKGFTG 831

Query: 361 TIDKSIGG 368
            ID++  G
Sbjct: 832 IIDQNENG 839


>A4I3V9_LEIIN (tr|A4I3V9) DNA topoisomerase 2 (Fragment) OS=Leishmania infantum
           GN=LINJ_28_2450 PE=3 SV=2
          Length = 1252

 Score =  368 bits (944), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 178/372 (47%), Positives = 259/372 (69%), Gaps = 9/372 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCNGIQK 62
           YG +M M+DQD+DGSHIKGLLINF +   P+LLR+P FL + ITPI++A         + 
Sbjct: 500 YGHLMIMSDQDHDGSHIKGLLINFIHCFWPNLLRVPGFLQQFITPIVKARPKGRGGAGKA 559

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +SF+S P+Y +W K  G+  S+++I+YYKGLG+   EEG+E+F+N++  R  FV +   +
Sbjct: 560 ISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGREYFENIDRHRLNFVEQEQSE 619

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSS----DYRDYTDLSICYKDFLQKEFILYSMASVRR 176
            D I +AF K +  +R+  +  FK++    +  DY    + Y+DF+ KE IL+S+A   R
Sbjct: 620 EDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYNVRQVSYRDFVDKELILFSIADCER 679

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS+IDG KP QRKIL+  FKR L   I+V +L GYV+EHSAYHH E SL  T++ MA+
Sbjct: 680 SIPSVIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSEHSAYHHGEQSLVQTIVGMAQ 739

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+ LL  +GQFGT + GGKDHA+ RYI+T L  +SR +F   D+ +++Y ++DG
Sbjct: 740 DFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMQVSRAIFHPADDFVVEYKDDDG 799

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
           +SVEP +Y+P+IP+VLVNG +GI TG++ SIP YNP +II+N++R +  +++  M PWY 
Sbjct: 800 LSVEPFFYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEIISNLERLMRGEEVHKMQPWYF 859

Query: 357 GFKGTIDKSIGG 368
           GF GT+++   G
Sbjct: 860 GFTGTMEEKEPG 871


>L8GML2_ACACA (tr|L8GML2) DNA topoisomerase 2 OS=Acanthamoeba castellanii str.
           Neff GN=ACA1_366710 PE=3 SV=1
          Length = 1559

 Score =  368 bits (944), Expect = 3e-99,   Method: Compositional matrix adjust.
 Identities = 177/358 (49%), Positives = 240/358 (67%), Gaps = 3/358 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YGR+M M DQD+DGSHIKGL+INF +   P LL+ P FL+E ITPI++A      + +SF
Sbjct: 547 YGRLMIMTDQDHDGSHIKGLVINFVHHFWPDLLKTPGFLTEFITPIVKA--TKKKETISF 604

Query: 66  YSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           Y+  EYE W +   N   W+IKYYKGLG+ + +E KE+F  ++  +  F W  DED DAI
Sbjct: 605 YTMTEYETWKEENNNGQGWKIKYYKGLGTSSAQEAKEYFSELQRHKIDFAWGGDEDGDAI 664

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           ++AFSK +  +R+  + KF+   + D     + Y DF+ KE I +S+A   R IPSL+DG
Sbjct: 665 DMAFSKKRVEDRKTWISKFEPGTFLDQDVDELPYSDFIHKELIHFSIADCARSIPSLVDG 724

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KP QRKILY    + +  EIRV +L G V+ HSAYHH E SL   ++ MA ++VGS NI
Sbjct: 725 LKPGQRKILYTCLSKNIKEEIRVAQLSGSVSLHSAYHHGEESLNKAIVAMAHNFVGSNNI 784

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLL   G FG+ + GGKD AS RY++T L  I+R +F   D+KLL YL +DG+ VEPE+Y
Sbjct: 785 NLLFPAGSFGSRLHGGKDAASARYLHTRLCEITRTIFHPDDDKLLNYLEDDGLPVEPEFY 844

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
           +PIIPL LVNG  GI TGW+  +P YNP+DI+ NIKR L ++  + M+PWY+ F+G +
Sbjct: 845 VPIIPLSLVNGGEGIGTGWSTFVPNYNPRDIVDNIKRMLRNETPKEMIPWYRAFEGQL 902


>G0R0E4_ICHMG (tr|G0R0E4) Putative uncharacterized protein OS=Ichthyophthirius
           multifiliis (strain G5) GN=IMG5_163890 PE=4 SV=1
          Length = 967

 Score =  368 bits (944), Expect = 3e-99,   Method: Compositional matrix adjust.
 Identities = 183/369 (49%), Positives = 248/369 (67%), Gaps = 4/369 (1%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQ 61
           +S  YG +M M DQD DGSHIKGLLINF +   PSL R+  FL E +TPII+A   N I 
Sbjct: 297 KSLRYGSIMIMTDQDSDGSHIKGLLINFIHYFWPSLFRMNGFLKEFVTPIIKATKGNEIH 356

Query: 62  KLSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
             SF++  +++ +    GN    +++KYYKGLG+ T +E KE+F NV   +  F++ +DE
Sbjct: 357 --SFFTIQDFKNFATQQGNRLKQYKVKYYKGLGTSTDKEAKEYFSNVYDHQIKFLYEDDE 414

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D   I + FS+ K +ER+  +  +  + + DY    + +KDF+ KE I +S +   R IP
Sbjct: 415 DFQRIELGFSRKKIQERKDWLAIYNPNLFVDYNIKQLRFKDFIDKELIHFSNSDNLRSIP 474

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S++DG KP QRKIL+  FKR L  EI+V +L GYVAEHSAYHH E SLA T++ MA+++V
Sbjct: 475 SVVDGLKPGQRKILFACFKRNLKNEIKVAQLQGYVAEHSAYHHGEQSLAQTIINMAQNFV 534

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           G+ NI+LL   GQFGT  QGGK+HAS RYI+T L+PI+R +FPE D+  LKYL +D   V
Sbjct: 535 GANNISLLEPIGQFGTRNQGGKEHASSRYIFTNLSPITRLIFPEPDDHSLKYLEDDSQLV 594

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPEWY+PIIPL LVNG  GI TGW+ +IP YN ++I+  I+  L+      + PWYKGF+
Sbjct: 595 EPEWYIPIIPLCLVNGSEGIGTGWSTNIPNYNHREIVEQIRNRLDGKPFTQIHPWYKGFQ 654

Query: 360 GTIDKSIGG 368
           GTI+ S  G
Sbjct: 655 GTIEISNKG 663


>Q4Q836_LEIMA (tr|Q4Q836) DNA topoisomerase 2 OS=Leishmania major GN=LMJF_28_2280
           PE=3 SV=1
          Length = 1497

 Score =  367 bits (943), Expect = 3e-99,   Method: Compositional matrix adjust.
 Identities = 177/372 (47%), Positives = 259/372 (69%), Gaps = 9/372 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCNGIQK 62
           YG +M M+DQD+DGSHIKGLLINF +   P+LLR+P FL + ITPI++A         + 
Sbjct: 500 YGHLMIMSDQDHDGSHIKGLLINFIHCFWPNLLRVPGFLQQFITPIVKARPKGRGGAGKA 559

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +SF+S P+Y +W K  G+  S+++I+YYKGLG+   EEG+E+F+N++  R  FV +   +
Sbjct: 560 ISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGREYFENIDRHRLNFVEQEQSE 619

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSS----DYRDYTDLSICYKDFLQKEFILYSMASVRR 176
            D I +AF K +  +R+  +  FK++    +  DY    + Y+DF+ KE IL+S+A   R
Sbjct: 620 EDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYNVRQVSYRDFVDKELILFSIADCER 679

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS+IDG KP QRKIL+  FKR L   I+V +L GYV+EHSAYHH E SL  T++ MA+
Sbjct: 680 SIPSVIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSEHSAYHHGEQSLVQTIVGMAQ 739

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+ LL  +GQFGT + GGKDHA+ RYI+T L  ++R +F   D+ +++Y ++DG
Sbjct: 740 DFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMQVARAIFHPADDFVVEYKDDDG 799

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
           +SVEP +Y+P+IP+VLVNG +GI TG++ SIP YNP +II+N++R +  +++  M PWY 
Sbjct: 800 LSVEPFFYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEIISNLERLMRGEEVHKMQPWYF 859

Query: 357 GFKGTIDKSIGG 368
           GF GT+++   G
Sbjct: 860 GFTGTMEEKEPG 871


>M1IA64_9PHYC (tr|M1IA64) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus OR0704.2.2 GN=OR0704.2.2_624R PE=3 SV=1
          Length = 1059

 Score =  367 bits (942), Expect = 4e-99,   Method: Compositional matrix adjust.
 Identities = 183/368 (49%), Positives = 247/368 (67%), Gaps = 5/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M D D DGSHI  L++NFF+   PSLL +P FL +  TPI+ A     I +
Sbjct: 475 SLRYGSVMLMTDADVDGSHISALVMNFFHAQFPSLLAVPGFLKKFSTPIVVASRGKDINE 534

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
             FYS P+YE W KN  + + W IKY+KGLG+ T E+ K++F+N++   K F W  D   
Sbjct: 535 --FYSLPDYESWKKNTADCAKWSIKYFKGLGTSTSEDAKKYFKNLKSLVKIFGWTEDSG- 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I+ +F+KS+  ER+  +L F+  +  D +  +I   DF+ KE IL+S   V R IPS+
Sbjct: 592 ELIDRSFNKSRPDERKTWLLNFQPGNQLDQSKTNIPVPDFIDKELILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AFKR L  E++V +  GYVAEHS YHH E SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFAAFKRNLTNEMKVAQFSGYVAEHSGYHHGEQSLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMAN-GQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
            N   L+   GQFG+ + GGKD AS RYI+T+L+P++R +F + D+ LLKYL +DG S+E
Sbjct: 712 NNNMNLLLPNGQFGSRLLGGKDSASARYIFTKLSPVTRQVFNQTDDVLLKYLEDDGSSIE 771

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PEWY+P IP +LVNG +GI TG++  IP YNPKDII N+KR +   ++ PM PWYKGF G
Sbjct: 772 PEWYVPAIPFLLVNGANGIGTGFSTDIPSYNPKDIIDNVKRLIAGKEMVPMTPWYKGFTG 831

Query: 361 TIDKSIGG 368
            ID++  G
Sbjct: 832 IIDQNENG 839


>A5E7X7_LODEL (tr|A5E7X7) DNA topoisomerase 2 OS=Lodderomyces elongisporus
           (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 /
           NRRL YB-4239) GN=LELG_05716 PE=3 SV=1
          Length = 1492

 Score =  367 bits (941), Expect = 6e-99,   Method: Compositional matrix adjust.
 Identities = 182/367 (49%), Positives = 243/367 (66%), Gaps = 3/367 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIR-AFHCNG 59
           ++S  YG +M M DQD DGSHIKGL+INF     P LL IP FL + ITPI++   +  G
Sbjct: 591 IKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLQFITPIVKVTVNGRG 650

Query: 60  IQK-LSFYSYPEYEKWWKNWG-NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
            +K + FYS PE+E W +  G N  W  KYYKGLG+ T  E +E+F  ++   K F    
Sbjct: 651 AKKVIPFYSMPEFEAWREGEGQNCRWTQKYYKGLGTSTPLEAREYFTALDRHLKRFHALQ 710

Query: 118 DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRC 177
            ED   I++AFSK K  +R+  +  F   D  D     I   DF+ KE IL+SM+   R 
Sbjct: 711 GEDASCIDLAFSKKKADDRKEWLQNFVPGDNLDPEMNEIPISDFINKELILFSMSDNVRS 770

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS++DG KP QRKILYG FKR+L  EI+V +L  YVA+ S+YHH E SL  T++ MA++
Sbjct: 771 IPSMLDGLKPGQRKILYGCFKRKLKNEIKVAQLAAYVADVSSYHHGEQSLVQTIIAMAQN 830

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           +VGS NINLL  NG FG+   GGKD A+ RYI+TELN I+R +F E D+ LL YL +D  
Sbjct: 831 FVGSNNINLLKPNGAFGSRATGGKDAAAARYIFTELNEITRTIFNEADDPLLNYLQDDES 890

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
           +VEP+WYLP++P++LVNG  GI TGW+ +IP YNP DI+AN++R +  + ++ M PWYKG
Sbjct: 891 TVEPQWYLPVLPMILVNGADGIGTGWSTNIPSYNPLDIVANLRRLMRGEPMEEMNPWYKG 950

Query: 358 FKGTIDK 364
           + G I+K
Sbjct: 951 WYGDIEK 957


>A4HGT2_LEIBR (tr|A4HGT2) DNA topoisomerase 2 OS=Leishmania braziliensis
           GN=LBRM_28_2480 PE=3 SV=1
          Length = 1501

 Score =  366 bits (940), Expect = 6e-99,   Method: Compositional matrix adjust.
 Identities = 176/372 (47%), Positives = 259/372 (69%), Gaps = 9/372 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCNGIQK 62
           YG +M M+DQD+DGSHIKGLLINF +   P+LLR+P FL + ITPI++A         + 
Sbjct: 500 YGHLMIMSDQDHDGSHIKGLLINFIHCFWPNLLRVPGFLQQFITPIVKARPKGRGGAGKA 559

Query: 63  LSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           +SF+S P+Y +W K  G+  S+++I+YYKGLG+   EEG+E+F+N++  R  FV ++  +
Sbjct: 560 ISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGREYFENIDRHRLSFVEQDQSE 619

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSS----DYRDYTDLSICYKDFLQKEFILYSMASVRR 176
            D I +AF K +  +R+  +  FK++    +  DY+   + Y+DF+ KE IL+S+A   R
Sbjct: 620 EDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYSVRQVSYRDFVDKELILFSIADCER 679

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS IDG KP QRKIL+  FKR L   I+V +L GYV+EHSAYHH E SL  T++ MA+
Sbjct: 680 SIPSAIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSEHSAYHHGEQSLVQTIVGMAQ 739

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+ LL  +GQFGT + GGKDHA+ RYI+T L  ++R +F   D+ +++Y ++DG
Sbjct: 740 DFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMHVARAIFHPADDFVVEYKDDDG 799

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
           +SVEP +Y+P+IP+VLVNG +GI TG++ SIP YNP ++I N++R +  +++  M PWY 
Sbjct: 800 LSVEPFYYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEVIRNLERLMRGEEVHKMQPWYF 859

Query: 357 GFKGTIDKSIGG 368
           GF GT+++   G
Sbjct: 860 GFTGTMEEKEPG 871


>J0XI42_LOALO (tr|J0XI42) DNA topoisomerase 2 OS=Loa loa GN=LOAG_17616 PE=3 SV=1
          Length = 1352

 Score =  366 bits (940), Expect = 7e-99,   Method: Compositional matrix adjust.
 Identities = 179/377 (47%), Positives = 255/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG++M MADQD DGSHIKGL+INF +   P L+R   F+ E ITPI++A    G 
Sbjct: 577 MKTLRYGKIMVMADQDQDGSHIKGLVINFIHYNWPVLIR-RNFVEEFITPIVKA--TKGK 633

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +  SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  +E
Sbjct: 634 ESFSFFSLPEYAEWRNNTENWKTYRIKYYKGLGTSTSKEAKEYFTDMVRHRIRFQYSGEE 693

Query: 120 DLDAINIAFSKSKTRERR----GLMLKFKSSDYRDYTD--------LSICYKDFLQKEFI 167
           D +++++AFSK K  +R+      M + K+   +  T+         ++ +KDF+ KE +
Sbjct: 694 DDNSLDMAFSKKKIEDRKVWLTNWMAEKKARREQGLTEEYLYNKDTRAVSFKDFVNKELV 753

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S A   R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 754 LFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 813

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP++R LFP +D  
Sbjct: 814 MSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTRALFPIVDEN 873

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  IP YNP++I+ N++R +  ++
Sbjct: 874 VLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKIPNYNPREIVDNMRRLIRGEE 933

Query: 348 LQPMVPWYKGFKGTIDK 364
            + + PW+K F+GTI+K
Sbjct: 934 PKSLTPWFKNFRGTIEK 950


>M1HYL7_9PHYC (tr|M1HYL7) DNA topoisomerase II OS=Acanthocystis turfacea
           Chlorella virus NE-JV-3 GN=NE-JV-3_656L PE=3 SV=1
          Length = 1058

 Score =  366 bits (940), Expect = 7e-99,   Method: Compositional matrix adjust.
 Identities = 173/368 (47%), Positives = 250/368 (67%), Gaps = 4/368 (1%)

Query: 3   SFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQK 62
           S  YG VM M+DQD DGSHI GL++NFF+   PSLL IP FL   +TPI+ A    G + 
Sbjct: 475 SLRYGSVMIMSDQDVDGSHIAGLVLNFFHAQFPSLLEIPGFLKRFVTPIVVA--KKGTKM 532

Query: 63  LSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           + FYS P++E+W     + S W+ KYYKGLG+    + K +F N+++  K   W +D+  
Sbjct: 533 VEFYSIPDFEEWKAATPDVSTWKTKYYKGLGTSDANDAKRYFNNLKVLVKTLTW-SDDAA 591

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           ++I+ +F+KS+  ER+  +L FK  +  D     I  +DF+ K+ IL+S   V R IPS+
Sbjct: 592 ESIDKSFNKSRADERKTWLLDFKPGNQLDQKLTKIPVEDFINKDLILFSRYDVERSIPSV 651

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KPSQRKIL+ AF+R L +EI+V +  GYV+EH+ YHH E+SL   ++ MA+DYVGS
Sbjct: 652 VDGLKPSQRKILFSAFRRNLTSEIKVAQFSGYVSEHAGYHHGEASLQGAIVGMAQDYVGS 711

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NINLL+  G FG+ + GGKD AS RYI+T+L+P +R +F + D +LL YL +DG  +EP
Sbjct: 712 NNINLLLPRGSFGSRLHGGKDSASARYIFTQLSPNTRDIFHKADERLLNYLEDDGDKIEP 771

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E+Y+P IP +LVNG +GI TG++ +IP YNP++I+ N+KR ++   +  M PWY+GFKG 
Sbjct: 772 EYYVPTIPFLLVNGANGIGTGFSTNIPSYNPREIVDNVKRLIDGKAMAEMTPWYRGFKGI 831

Query: 362 IDKSIGGM 369
           I ++  G+
Sbjct: 832 IKEASPGV 839


>H2LHR6_ORYLA (tr|H2LHR6) DNA topoisomerase 2 (Fragment) OS=Oryzias latipes PE=3
           SV=1
          Length = 1587

 Score =  365 bits (938), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 188/377 (49%), Positives = 251/377 (66%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A   N  
Sbjct: 562 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKA--SNKK 618

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W +   N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 619 NQLSFYSIPEFNAWKETQSNHKSWKIKYYKGLGTSTSQEAKEYFSDMERHRIPFKYSGPE 678

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI++AFSK K  ER+  +  F  +  +        DY    +  S+ Y DF+ KE +
Sbjct: 679 DDEAISLAFSKKKVEERKEWLTNFMVNRRQRREHNLPEDYLYGQSTKSLSYNDFINKELV 738

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 739 LFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 798

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R +FP +D+ 
Sbjct: 799 MMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSPLARLVFPPVDDN 858

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP VLVNG  GI TGW   IP Y+ ++I++NI R L+ ++
Sbjct: 859 LLKYNYDDNQRVEPEWYIPIIPTVLVNGAEGIGTGWASKIPNYDIREIVSNIHRMLDGEE 918

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YKGF+GTID+
Sbjct: 919 PLPMLPNYKGFRGTIDQ 935


>M1I1I6_9PHYC (tr|M1I1I6) DNA topoisomerase II OS=Paramecium bursaria Chlorella
           virus NE-JV-1 GN=NE-JV-1_628R PE=3 SV=1
          Length = 1057

 Score =  365 bits (938), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 181/365 (49%), Positives = 249/365 (68%), Gaps = 4/365 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG VM M D D DGSHI GL++NFF+   PSLL IP FL +  TPI+ A +   I  + F
Sbjct: 478 YGSVMIMTDADVDGSHISGLVMNFFHSQFPSLLEIPGFLKKFTTPIVVASYKKEI--VEF 535

Query: 66  YSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           YS P++++W K   N D +  KY+KGLG+ T E+ K +F+N++   K F W +D   + I
Sbjct: 536 YSLPDFDEWKKETPNHDKYSKKYFKGLGTSTTEDAKRYFKNLKGLMKMFDWTDDSG-ELI 594

Query: 125 NIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           + +F+KS+  +R+  +L F   +  D     I   DF+ KE IL+S   V R IPS++DG
Sbjct: 595 DRSFNKSRPDDRKKWLLDFVPGNQIDQKKSRIPVPDFIDKELILFSRYDVERSIPSVVDG 654

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            KPSQRKIL+ AFKR L TE++V +  GYVAEHS YHH E+SL   ++ MA+D+VGS N+
Sbjct: 655 FKPSQRKILFSAFKRNLTTEMKVAQFSGYVAEHSGYHHGEASLQGAIIGMAQDFVGSNNV 714

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLLM NGQFG+ + GGKD AS RYI+T L+PI+R +F + D+ LLKYL +DG  +EPE+Y
Sbjct: 715 NLLMPNGQFGSRLMGGKDSASARYIFTMLSPIARKIFDKADDVLLKYLEDDGDIIEPEYY 774

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PIIP +LVNG +GI TG++ S+P YNPKDI AN+KR +  + +  M PWY+GF G I++
Sbjct: 775 VPIIPFLLVNGANGIGTGFSTSVPSYNPKDIAANVKRLIAGEDMISMTPWYRGFTGKIEE 834

Query: 365 SIGGM 369
              G+
Sbjct: 835 KEPGV 839


>A7ANB1_BABBO (tr|A7ANB1) DNA topoisomerase 2 OS=Babesia bovis GN=BBOV_III004820
           PE=3 SV=1
          Length = 1437

 Score =  365 bits (938), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 170/363 (46%), Positives = 251/363 (69%), Gaps = 2/363 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   P +++   F+ E +TPII+A   + +  LSF
Sbjct: 512 YGSIMIMTDQDYDGSHIKGLLINLLHYFWPKMIQCRGFIREFVTPIIKATKGDSV--LSF 569

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           ++  +Y +W ++   + W+IKYYKGLG+ T +E KE+F N++     F++ ++ D D+I+
Sbjct: 570 FTVQDYVRWVQSTNVAGWKIKYYKGLGTSTDKEFKEYFVNIQQHLIDFIYEDNADDDSID 629

Query: 126 IAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDGQ 185
           +AF+K +  +R+  M  ++     D++   + Y DF+ KE I +S+    R IPS++DG 
Sbjct: 630 LAFNKKRVDDRKLWMQSYEHGTTVDHSIKKLRYTDFINKELIQFSIYDTERSIPSVVDGW 689

Query: 186 KPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNIN 245
           KP QRK+L+G  KR L  E +V +L GYVAEHSAYHH E+SL  T++ MA+++VGS NIN
Sbjct: 690 KPGQRKVLFGCLKRNLVGECKVAQLTGYVAEHSAYHHGEASLQQTIINMAQNFVGSNNIN 749

Query: 246 LLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWYL 305
           +L   GQFG+  +GGKD ++ RYI+T+LNPI+R +F E D+ +L+Y NE+G ++EP +Y+
Sbjct: 750 VLEPCGQFGSRKEGGKDASAARYIFTKLNPITRLIFVEEDDNILEYQNEEGQTIEPMYYI 809

Query: 306 PIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDKS 365
           P IP+VLVNG  GI TG++  IP YNP DII N+KR+LN+  ++PMVPWY  F G I+ +
Sbjct: 810 PTIPMVLVNGSEGIGTGFSSQIPNYNPLDIIDNLKRYLNNVDMKPMVPWYHKFTGEIEPN 869

Query: 366 IGG 368
             G
Sbjct: 870 DKG 872


>Q6BQW4_DEBHA (tr|Q6BQW4) DNA topoisomerase 2 OS=Debaryomyces hansenii (strain
           ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
           GN=DEHA2E01738g PE=3 SV=2
          Length = 1411

 Score =  365 bits (937), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 172/366 (46%), Positives = 245/366 (66%), Gaps = 4/366 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HC 57
           + +  YG +M M DQD DGSHIKGL+INF     P LL++P FL E ITPI++       
Sbjct: 555 INTLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLQVPGFLLEFITPIVKVTVNRRG 614

Query: 58  NGIQKLSFYSYPEYEKWWKNWG-NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWR 116
           +G Q + FY+ PE+EKW    G    W  KYYKGLG+ T  EG+E+F  ++   K F   
Sbjct: 615 SGKQVIPFYTMPEFEKWRDTEGLTCRWTQKYYKGLGTSTDAEGREYFSALDKHLKTFHAL 674

Query: 117 NDEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRR 176
             +D   I++AFSK K  +R+  +  F+   + D     I   DF+ KE IL+SMA   R
Sbjct: 675 QGDDQQLIDLAFSKKKADDRKEWLQGFEPGTHLDPDLEEIPISDFINKELILFSMADNVR 734

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS++DG KP QRK+LYG FKR L +EI+V++L GYV+E++ YHH E SL  T++ +A+
Sbjct: 735 SIPSVLDGFKPGQRKVLYGCFKRNLKSEIKVNQLAGYVSENTGYHHGEQSLVQTIIGLAQ 794

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D++GS N+N+L  NG FG+   GGKD ++PRYI+TE+N I+R +F  +DN L KY+ +D 
Sbjct: 795 DFIGSNNLNILKPNGSFGSRAAGGKDFSAPRYIFTEINEITRKIFNPLDNALYKYVQDDE 854

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
            +VEPEWYLP++P++LVNG  GI TGW+ ++P +NP DI+ NIK+ +N +++  M PWY+
Sbjct: 855 QTVEPEWYLPVLPMLLVNGSEGIGTGWSTNVPPFNPTDIVNNIKKLMNGEEMNEMSPWYR 914

Query: 357 GFKGTI 362
           G++G I
Sbjct: 915 GWEGEI 920


>M5FVQ8_DACSP (tr|M5FVQ8) DNA topoisomerase II OS=Dacryopinax sp. (strain DJM
           731) GN=DACRYDRAFT_54567 PE=4 SV=1
          Length = 1365

 Score =  365 bits (936), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 176/371 (47%), Positives = 247/371 (66%), Gaps = 3/371 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG +M M DQD+DGSHIKGL+INF     PSLL+IP FL E ITPI+R  H    
Sbjct: 612 VDSLRYGSIMIMTDQDFDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVRVTHKRTR 671

Query: 61  QKLSFYSYPEYEKWWKNWGNSDW---RIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
           ++ +F++ PEYE+W +   +        KY+KGLG+   E+G E+F N+E     F    
Sbjct: 672 KRTTFFTMPEYEEWAEQHKHDKHLYEDPKYFKGLGTSGPEDGMEYFGNMETHLIPFHPTQ 731

Query: 118 DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRC 177
           + + + I++AFSK K   R+  +  FK   Y D++   I Y DF+ KE IL+SMA   R 
Sbjct: 732 EGERELIDMAFSKKKVEARKDWLRNFKPGTYMDHSVDEITYDDFINKELILFSMADNIRS 791

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS+ DG KP  RK+L+G FKR L  EI+V +L GY+ EH+AYHH E SL +T++ MA++
Sbjct: 792 IPSMCDGLKPGHRKVLFGVFKRNLKNEIKVAQLAGYIGEHTAYHHGEQSLHSTIIGMAQN 851

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           +VG+ N+NLL+ +G FG+   GG+D A+ RY+ T L  I+R +F   D+ +L YL EDG 
Sbjct: 852 FVGANNLNLLIPSGGFGSRSMGGEDAAAARYLNTNLMAITRSVFHSADDNILTYLMEDGK 911

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
            +EPE+YLPIIP+VLVNG SGI TGW+ +IP +NP DI+ANI+R++  + L+PM PWY+ 
Sbjct: 912 RIEPEFYLPIIPMVLVNGSSGIGTGWSTNIPSFNPVDIVANIRRYMRHEPLEPMSPWYRN 971

Query: 358 FKGTIDKSIGG 368
           F G+ +K   G
Sbjct: 972 FLGSFEKVSEG 982


>G3UST0_MELGA (tr|G3UST0) DNA topoisomerase 2 (Fragment) OS=Meleagris gallopavo
           PE=3 SV=1
          Length = 1508

 Score =  364 bits (935), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 182/377 (48%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A      
Sbjct: 487 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKA--SKNK 543

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++++FYS PE+E+W  +  N + W+IKYYKGLG+ T +E KE+F ++   R  F +   E
Sbjct: 544 EEIAFYSIPEFEEWKNSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPE 603

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKS-----------SDYRDYTDLS-ICYKDFLQKEFI 167
           D  AI +AFSK K  ER+  +  F              DY    D + + Y DF+ KE +
Sbjct: 604 DDAAITLAFSKKKVEERKEWLTNFMEDRRQRKLQGLPEDYLYGKDTNYLTYNDFINKELV 663

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE S+YHH E+SL
Sbjct: 664 LFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEASL 723

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+ 
Sbjct: 724 MMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDN 783

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L +D   VEPEWY+PIIP+VL+NG  GI TGW+C IP ++ ++ + NI+R L+ ++
Sbjct: 784 VLRFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRRLLDGNE 843

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YK FKGTID+
Sbjct: 844 PLPMLPSYKNFKGTIDE 860


>R0JC34_ANAPL (tr|R0JC34) DNA topoisomerase 2-beta (Fragment) OS=Anas
           platyrhynchos GN=Anapl_09198 PE=4 SV=1
          Length = 1605

 Score =  364 bits (934), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 532 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 588

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 589 QELSFYSIPEFDEWKKHMENHKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 648

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 649 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 707

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 708 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 767

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 768 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLFPSVDD 827

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 828 NLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVRRMLDGL 887

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 888 DPHPMLPNYKNFKGTI 903


>H0YZ82_TAEGU (tr|H0YZ82) DNA topoisomerase 2 OS=Taeniopygia guttata GN=TOP2B
           PE=3 SV=1
          Length = 1622

 Score =  364 bits (934), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 549 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 605

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 606 QELSFYSIPEFDEWKKHMENHKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 665

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 666 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 724

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 725 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 784

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 785 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLFPSVDD 844

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 845 NLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVRRMLDGL 904

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 905 DPHPMLPNYKNFKGTI 920


>E6ZGS7_DICLA (tr|E6ZGS7) DNA topoisomerase 2 (Fragment) OS=Dicentrarchus labrax
           GN=TOP2A PE=3 SV=1
          Length = 968

 Score =  364 bits (934), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 188/376 (50%), Positives = 247/376 (65%), Gaps = 16/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+  H    
Sbjct: 515 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKVSHKK-- 571

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W  +  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 572 TQLSFYSIPEFNSWKDSQPNHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 631

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  +  F  +  +        DY       S+ Y DF+ KE +
Sbjct: 632 DDEAITLAFSKKKVEERKEWLTNFMVNRRQRREHNLPEDYLYGQATKSLSYNDFVNKELV 691

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 692 LFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 751

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R +FP +D+ 
Sbjct: 752 MMTIVGLAQNFVGSNNMNLLQPLGQFGTRLHGGKDSASPRYIFTMLSPLARLVFPSVDDN 811

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP VLVNG  GI TGW   IP YN ++I++NI R LN D+
Sbjct: 812 LLKYNYDDNQRVEPEWYMPIIPTVLVNGAEGIGTGWASKIPNYNIREIVSNIHRMLNGDE 871

Query: 348 LQPMVPWYKGFKGTID 363
             PM+P YKGF+GTI+
Sbjct: 872 PLPMLPNYKGFRGTIE 887


>G3UST4_MELGA (tr|G3UST4) DNA topoisomerase 2 (Fragment) OS=Meleagris gallopavo
           PE=3 SV=1
          Length = 1453

 Score =  364 bits (934), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 182/377 (48%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A      
Sbjct: 521 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKA--SKNK 577

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++++FYS PE+E+W  +  N + W+IKYYKGLG+ T +E KE+F ++   R  F +   E
Sbjct: 578 EEIAFYSIPEFEEWKNSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPE 637

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKS-----------SDYRDYTDLS-ICYKDFLQKEFI 167
           D  AI +AFSK K  ER+  +  F              DY    D + + Y DF+ KE +
Sbjct: 638 DDAAITLAFSKKKVEERKEWLTNFMEDRRQRKLQGLPEDYLYGKDTNYLTYNDFINKELV 697

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE S+YHH E+SL
Sbjct: 698 LFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEASL 757

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+ 
Sbjct: 758 MMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDN 817

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L +D   VEPEWY+PIIP+VL+NG  GI TGW+C IP ++ ++ + NI+R L+ ++
Sbjct: 818 VLRFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRRLLDGNE 877

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YK FKGTID+
Sbjct: 878 PLPMLPSYKNFKGTIDE 894


>G3NZ45_GASAC (tr|G3NZ45) DNA topoisomerase 2 OS=Gasterosteus aculeatus GN=TOP2B
           PE=3 SV=1
          Length = 1583

 Score =  364 bits (934), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 186/376 (49%), Positives = 243/376 (64%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINFF+   PSLL+   FL E ITPI++       
Sbjct: 517 LKSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HTFLEEFITPIVKV--TKNK 573

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+ +FYS PE+++W KN  N   W IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 574 QESAFYSIPEFDEWKKNTENFKTWHIKYYKGLGTSTSKEAKEYFADMEKHRISFRYSGAE 633

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK KT +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 634 DDAAITLAFSKKKTDDRKEWLTNF-MEDRRQRRMHGLPEQYLYGTQARHLSYNDFINKEL 692

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 693 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQA 752

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+N+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP  D+
Sbjct: 753 LMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPSGDS 812

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ NI R LN  
Sbjct: 813 NLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRLLNHQ 872

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKG I
Sbjct: 873 DPLPMLPRYKNFKGVI 888


>A0D9B8_PARTE (tr|A0D9B8) DNA topoisomerase 2 OS=Paramecium tetraurelia
           GN=GSPATT00014565001 PE=3 SV=1
          Length = 1272

 Score =  364 bits (934), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 176/363 (48%), Positives = 247/363 (68%), Gaps = 2/363 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG VM M DQD DGSHIKGL+INF +   PSL++   FL E +TP+I+A    G 
Sbjct: 500 LKSLRYGSVMIMTDQDIDGSHIKGLIINFIHHFWPSLVKYRGFLKEFVTPLIKA--TKGN 557

Query: 61  QKLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           Q + F++  ++ K+ +      W+IKYYKGLG+   +E +E+F+N+      F +  D+D
Sbjct: 558 QTIPFFTVQDFNKFAQEEDIKTWKIKYYKGLGTSDDQEAQEYFKNLRTHTIQFRYDGDDD 617

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
            ++I++ F+K K  +R+  + ++    Y D+T   + Y +F+ KE I +SMA   R IPS
Sbjct: 618 DNSIDLCFNKKKANDRKQWLAQYNHDLYVDHTKSELGYSEFIHKELIHFSMADNIRSIPS 677

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KP QRK+L+  FKR L  EI+V +L GY+AEHSAYHH + SL +T++ MA+++VG
Sbjct: 678 LMDGLKPGQRKVLFACFKRNLKQEIKVVQLGGYIAEHSAYHHGDLSLVSTIIGMAQNFVG 737

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+  GQFG+   GGKDHAS RYI T LN I+R++FPE D+ LLKYL +DG  VE
Sbjct: 738 SNNINLLLPKGQFGSRAMGGKDHASARYISTALNKITRYIFPEQDDHLLKYLEDDGQMVE 797

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PE+Y+PIIP+ LVNG  GI TGW+ SI  YNP D++  IK  LN ++ QPM P+Y+ F G
Sbjct: 798 PEYYVPIIPMSLVNGAEGIGTGWSTSIQNYNPIDLVQQIKNRLNGEQFQPMAPFYRNFDG 857

Query: 361 TID 363
            I+
Sbjct: 858 IIE 860


>G1NF24_MELGA (tr|G1NF24) DNA topoisomerase 2 (Fragment) OS=Meleagris gallopavo
           PE=3 SV=2
          Length = 1602

 Score =  364 bits (934), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 526 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 582

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 583 QELSFYSIPEFDEWKKHMENHKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 642

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 643 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 701

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 702 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 761

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 762 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLFPSVDD 821

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 822 NLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVRRMLDGL 881

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 882 DPHPMLPNYKNFKGTI 897


>E7R9F3_PICAD (tr|E7R9F3) DNA topoisomerase 2 OS=Pichia angusta (strain ATCC
           26012 / NRRL Y-7560 / DL-1) GN=HPODL_3226 PE=3 SV=1
          Length = 1372

 Score =  363 bits (933), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 168/363 (46%), Positives = 248/363 (68%), Gaps = 4/363 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI---QK 62
           YG +M M+DQD+DGSHIKGL+INF     P LL IP FL E ITPI++     G    +K
Sbjct: 564 YGHIMIMSDQDHDGSHIKGLIINFLETSFPGLLEIPGFLIEFITPIVKVTILTGPDKNKK 623

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
           +SF++ PEYE+W    G +  ++ KYYKGLG+    E +E+F  ++   K F    +ED+
Sbjct: 624 ISFFNMPEYEEWRDTIGKTCSYKQKYYKGLGTSLPTEMREYFSQLDRHLKTFHTLQEEDV 683

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
             I++AFSK K  +R+  +  F+   + D     I   +F+ KE IL+SMA   R IPS+
Sbjct: 684 SLIDLAFSKKKADDRKEWLRGFQPGTFLDPNLTEIPISEFINKELILFSMADNIRSIPSV 743

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KP+QRK+LYG +KR L +EI+V +L+GY+ EHS YHH E+SL  T++ +A+D+VGS
Sbjct: 744 MDGFKPTQRKVLYGVYKRNLTSEIKVAQLVGYIGEHSGYHHGEASLTQTIISLAQDFVGS 803

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+N+L  NG FG+   GGKD ++ RYI+TE+ PI+R ++  +DN LL YL +D  +VEP
Sbjct: 804 NNLNILKPNGGFGSRASGGKDASAARYIFTEVTPITRKVYNTLDNPLLNYLQDDEQTVEP 863

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           +WY+P++P++LVNG  GI +GW+  IP +NP DI+ NI+  +N +++  M+PW+KG++GT
Sbjct: 864 QWYVPVLPMILVNGSEGIGSGWSTQIPPFNPVDIVKNIRALMNGEEMVDMIPWFKGWEGT 923

Query: 362 IDK 364
           I +
Sbjct: 924 ISR 926


>E3X4B6_ANODA (tr|E3X4B6) DNA topoisomerase 2 OS=Anopheles darlingi GN=AND_13286
           PE=3 SV=1
          Length = 1530

 Score =  363 bits (933), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 183/380 (48%), Positives = 254/380 (66%), Gaps = 16/380 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG+VM M DQD DGSHIKGLLINF +   P LLR+P FL E ITPI++A   NG 
Sbjct: 530 LKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNGT 588

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           + LSF+S PE+E+W     N+  + IKYYKGLG+ T +E KE+FQN+E  R  F + ++ 
Sbjct: 589 E-LSFFSLPEFEEWKAETPNAHTFNIKYYKGLGTSTSKEAKEYFQNMERHRILFRYEDNG 647

Query: 120 DLDAINIAFSKSKTRERRG-LMLKFKSSDYRDYTDL-----------SICYKDFLQKEFI 167
           D DAI +AFSK    +R+  L    +   +R    L           +I YKDF+  E +
Sbjct: 648 DDDAIMMAFSKKAVDQRKDWLTAHMEECRHRKQVGLQERYLYTKTTKAISYKDFVNLELV 707

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP ++DG KP QRK+++  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 708 LFSNSDNVRSIPCMLDGLKPGQRKVMFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQSL 767

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T L+ ++R +F  +D+ 
Sbjct: 768 CSTIINLAQNFVGSNNINLLYPGGQFGTRLTGGKDSASPRYIFTMLSTLTRLIFHPLDDP 827

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LL+Y  ED   +EP WYLPIIP++LVNG  GI TGW+  IP +NP+D+IANI+R LN ++
Sbjct: 828 LLEYQYEDNQRIEPVWYLPIIPMLLVNGAEGIGTGWSTKIPNHNPRDVIANIRRMLNGEE 887

Query: 348 LQPMVPWYKGFKGTIDKSIG 367
            + + PWYK F+G ++ S+G
Sbjct: 888 PKVLNPWYKNFRGLVE-SVG 906


>G1NAT9_MELGA (tr|G1NAT9) DNA topoisomerase 2 (Fragment) OS=Meleagris gallopavo
           PE=3 SV=1
          Length = 1499

 Score =  363 bits (933), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 182/377 (48%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A      
Sbjct: 487 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKA--SKNK 543

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++++FYS PE+E+W  +  N + W+IKYYKGLG+ T +E KE+F ++   R  F +   E
Sbjct: 544 EEIAFYSIPEFEEWKNSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPE 603

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKS-----------SDYRDYTDLS-ICYKDFLQKEFI 167
           D  AI +AFSK K  ER+  +  F              DY    D + + Y DF+ KE +
Sbjct: 604 DDAAITLAFSKKKVEERKEWLTNFMEDRRQRKLQGLPEDYLYGKDTNYLTYNDFINKELV 663

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE S+YHH E+SL
Sbjct: 664 LFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEASL 723

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+ 
Sbjct: 724 MMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDN 783

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L +D   VEPEWY+PIIP+VL+NG  GI TGW+C IP ++ ++ + NI+R L+ ++
Sbjct: 784 VLRFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRRLLDGNE 843

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YK FKGTID+
Sbjct: 844 PLPMLPSYKNFKGTIDE 860


>H2UY95_TAKRU (tr|H2UY95) DNA topoisomerase 2 (Fragment) OS=Takifugu rubripes
           GN=LOC101075432 PE=3 SV=1
          Length = 1581

 Score =  363 bits (933), Expect = 5e-98,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 249/376 (66%), Gaps = 16/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   F+ E ITPII+A H    
Sbjct: 525 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHKKS- 582

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 583 -QLSFYSIPEFNAWKESQANHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 641

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  +  F ++  +        DY    T   + Y DF+ KE +
Sbjct: 642 DDEAITLAFSKKKVEERKEWLTNFMTNRRQRREHNLPEDYLYGQTTKYLSYNDFVNKELV 701

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 702 LFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 761

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+N+L   GQFGT + GGKD ASPRYI+T L+ ++R +FP +D+ 
Sbjct: 762 MMTIVGLAQNFVGSNNLNMLQPLGQFGTRLHGGKDSASPRYIFTMLSTLTRLVFPPVDDN 821

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP+VLVNG  GI TGW   IP Y+ ++I+ NI R LN D+
Sbjct: 822 LLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDVREIVNNIHRMLNGDE 881

Query: 348 LQPMVPWYKGFKGTID 363
             PM+P YKGFKGTI+
Sbjct: 882 PLPMLPSYKGFKGTIE 897


>Q0IEA2_AEDAE (tr|Q0IEA2) DNA topoisomerase 2 (Fragment) OS=Aedes aegypti
           GN=AAEL012584 PE=3 SV=1
          Length = 1300

 Score =  363 bits (933), Expect = 5e-98,   Method: Compositional matrix adjust.
 Identities = 183/380 (48%), Positives = 258/380 (67%), Gaps = 16/380 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   P LLR+P FL E ITPI++A   NG 
Sbjct: 529 LKTLRYGKLMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNG- 586

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++LSF+S PE+E+W     N+  + IKYYKGLG+ T +E KE+FQN+E  R  F + + +
Sbjct: 587 EELSFFSLPEFEEWKTETPNAHTYNIKYYKGLGTSTSKEAKEYFQNMERHRILFKYDSTQ 646

Query: 120 DLDAINIAFSKSKTRERRG-LMLKFKSSDYRDYTDL-----------SICYKDFLQKEFI 167
           D +AI +AFSK    +R+  L    + + +R    L           +I YK+F+  E +
Sbjct: 647 DDEAITMAFSKKCVDQRKEWLTSHMEENRHRKQVGLPERYLYTKTTKAITYKEFINLELV 706

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP ++DG KP QRK+++  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 707 LFSNSDNIRSIPCMVDGLKPGQRKVMFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQSL 766

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A++YVGS NINLL+ +GQFGT + GGKD ASPRYI+T L+P++R +F  +D+ 
Sbjct: 767 CGTIVNLAQNYVGSNNINLLVPSGQFGTRLAGGKDSASPRYIFTMLSPLTRLIFHPLDDP 826

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LL+Y  +D   +EP WYLPIIP+VLVNG  GI TGW+  IP +NP+DII+N++R LN ++
Sbjct: 827 LLEYQYDDNQKIEPLWYLPIIPMVLVNGTEGIGTGWSTKIPNHNPRDIISNLRRMLNGEE 886

Query: 348 LQPMVPWYKGFKGTIDKSIG 367
            + M PWYK F+G I+ S+G
Sbjct: 887 PKIMHPWYKNFRGEIE-SVG 905


>H2UY96_TAKRU (tr|H2UY96) DNA topoisomerase 2 (Fragment) OS=Takifugu rubripes
           GN=LOC101075432 PE=3 SV=1
          Length = 1552

 Score =  363 bits (932), Expect = 5e-98,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 249/376 (66%), Gaps = 16/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   F+ E ITPII+A H    
Sbjct: 530 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHKKS- 587

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 588 -QLSFYSIPEFNAWKESQANHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 646

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  +  F ++  +        DY    T   + Y DF+ KE +
Sbjct: 647 DDEAITLAFSKKKVEERKEWLTNFMTNRRQRREHNLPEDYLYGQTTKYLSYNDFVNKELV 706

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 707 LFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 766

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+N+L   GQFGT + GGKD ASPRYI+T L+ ++R +FP +D+ 
Sbjct: 767 MMTIVGLAQNFVGSNNLNMLQPLGQFGTRLHGGKDSASPRYIFTMLSTLTRLVFPPVDDN 826

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP+VLVNG  GI TGW   IP Y+ ++I+ NI R LN D+
Sbjct: 827 LLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDVREIVNNIHRMLNGDE 886

Query: 348 LQPMVPWYKGFKGTID 363
             PM+P YKGFKGTI+
Sbjct: 887 PLPMLPSYKGFKGTIE 902


>E1BZ19_CHICK (tr|E1BZ19) DNA topoisomerase 2 OS=Gallus gallus GN=TOP2B PE=2 SV=2
          Length = 1627

 Score =  363 bits (932), Expect = 6e-98,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 554 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 610

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 611 QELSFYSIPEFDEWKKHMENHKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 670

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 671 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 729

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 730 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 789

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 790 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLFPSVDD 849

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 850 NLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVRRMLDGL 909

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK F+GTI
Sbjct: 910 DPHPMLPNYKNFRGTI 925


>I7M5X3_TETTS (tr|I7M5X3) DNA topoisomerase 2 OS=Tetrahymena thermophila (strain
           SB210) GN=TTHERM_00825440 PE=3 SV=1
          Length = 1416

 Score =  363 bits (931), Expect = 7e-98,   Method: Compositional matrix adjust.
 Identities = 179/360 (49%), Positives = 244/360 (67%), Gaps = 4/360 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M MADQD DGSHIKGL+INF +   PSL ++  FL E ITPI++     G +  SF
Sbjct: 511 YGSLMIMADQDSDGSHIKGLVINFIHHFWPSLFKMKGFLKEFITPILKV--TKGDEVHSF 568

Query: 66  YSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           ++  +++ +    G+    +++KYYKGLG+ T +E KE+F N    +  F + ++ D++A
Sbjct: 569 FTIQDFKNFAAQKGDRLKQYKVKYYKGLGTSTDKEAKEYFSNFYKHQINFQYLDENDMEA 628

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I + FS  K +ER+  +  +  + + DY    + YKDF+ +E I +S A   R IPSL D
Sbjct: 629 IELGFSGKKIKERKDWLANYDPNSFVDYNIKQLRYKDFIDRELIHFSNADNLRSIPSLCD 688

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRKIL+  FKR L +EI+V +LIGYVAEHSAYHH E SLA+T++ MA+++VGS N
Sbjct: 689 GLKPGQRKILFSCFKRNLKSEIKVAQLIGYVAEHSAYHHGEQSLASTIIGMAQNFVGSNN 748

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           INL+M  GQFGT  QGGK+HAS RYI+T L+ I+R LFPE D+ +LKYL +D   VEPEW
Sbjct: 749 INLMMPIGQFGTRNQGGKEHASARYIFTSLSKITRILFPEHDDHVLKYLEDDNQVVEPEW 808

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           Y+PIIP+ LVNG SGI TGW+  IP YN K+I+  I+  L       + PWYKGF+G I+
Sbjct: 809 YMPIIPMCLVNGSSGIGTGWSTDIPNYNHKEIVEQIRGKLEGKPFTELHPWYKGFQGQIE 868


>H2UY97_TAKRU (tr|H2UY97) DNA topoisomerase 2 (Fragment) OS=Takifugu rubripes
           GN=LOC101075432 PE=3 SV=1
          Length = 1349

 Score =  363 bits (931), Expect = 7e-98,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 249/376 (66%), Gaps = 16/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   F+ E ITPII+A H    
Sbjct: 503 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHKKS- 560

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 561 -QLSFYSIPEFNAWKESQANHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 619

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  +  F ++  +        DY    T   + Y DF+ KE +
Sbjct: 620 DDEAITLAFSKKKVEERKEWLTNFMTNRRQRREHNLPEDYLYGQTTKYLSYNDFVNKELV 679

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 680 LFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 739

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+N+L   GQFGT + GGKD ASPRYI+T L+ ++R +FP +D+ 
Sbjct: 740 MMTIVGLAQNFVGSNNLNMLQPLGQFGTRLHGGKDSASPRYIFTMLSTLTRLVFPPVDDN 799

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP+VLVNG  GI TGW   IP Y+ ++I+ NI R LN D+
Sbjct: 800 LLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDVREIVNNIHRMLNGDE 859

Query: 348 LQPMVPWYKGFKGTID 363
             PM+P YKGFKGTI+
Sbjct: 860 PLPMLPSYKGFKGTIE 875


>E5D8G5_9AGAR (tr|E5D8G5) DNA topoisomerase 2 OS=Omphalotus nidiformis GN=TopII
           PE=2 SV=1
          Length = 1557

 Score =  363 bits (931), Expect = 7e-98,   Method: Compositional matrix adjust.
 Identities = 173/366 (47%), Positives = 245/366 (66%), Gaps = 3/366 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YGR+M M DQD+DGSHIKGLLINF     PSLL++P FL E +TPIIR     G 
Sbjct: 621 VSSLRYGRLMIMTDQDHDGSHIKGLLINFLDHFYPSLLKVPDFLVEFVTPIIRV--TKGN 678

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+  F++ PEYE+W +    +D W  KY+KGLG+ T  + + +F N+      F    + 
Sbjct: 679 QRKDFFTIPEYEQWLETTPGADKWSTKYFKGLGTSTDADARGYFSNMAKHMIPFAPTQEG 738

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIP 179
           D + I +AFSK K  ER+  + +FK   +  +    I Y +F+ KE IL+SMA   R IP
Sbjct: 739 DRELIELAFSKKKADERKEWLRQFKPGTFLGHRLDEIPYSEFVNKELILFSMADNIRSIP 798

Query: 180 SLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYV 239
           S+ DG KP QRK+++  FKR L  EI+V +L+GYV+EHS YHH ++SL  T++ +A+D+V
Sbjct: 799 SIADGLKPDQRKVIWSCFKRNLKKEIKVIQLVGYVSEHSVYHHGDASLTQTIVALAQDFV 858

Query: 240 GSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISV 299
           GS N+NLL+  GQ+GT   GGKDHAS RYI T L PISR +F   D+ +L    ++   +
Sbjct: 859 GSNNLNLLVPCGQYGTRDMGGKDHASARYINTLLQPISRTIFNPDDDAILTPQTDENHVI 918

Query: 300 EPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFK 359
           EPE+Y+PI+P+VL+NG  GI TGW+ ++P +NP DI+ANI+R +N+++  PM PW++GFK
Sbjct: 919 EPEFYMPIVPMVLINGAEGIGTGWSTNVPGFNPLDIVANIRRLMNNEEQVPMHPWWRGFK 978

Query: 360 GTIDKS 365
           G I ++
Sbjct: 979 GEIKQT 984


>Q2PQ58_9TRYP (tr|Q2PQ58) DNA topoisomerase 2 OS=Trypanosoma brucei GN=TOP2beta
           PE=2 SV=1
          Length = 1465

 Score =  363 bits (931), Expect = 8e-98,   Method: Compositional matrix adjust.
 Identities = 177/377 (46%), Positives = 259/377 (68%), Gaps = 10/377 (2%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCN 58
           E   YG +M M+DQD+DGSHIKGL+IN  +   P LL++P FL + ITPI++A      N
Sbjct: 540 EGLRYGHLMIMSDQDHDGSHIKGLIINMIHNYWPDLLKVPGFLQQFITPIVKARKKGRGN 599

Query: 59  GIQ-KLSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVW 115
             +  +SF+S P+Y KW    G   SD+ +KYYKGLG+ + +EG+E+F+N++  R  FV+
Sbjct: 600 SDEGTISFFSMPDYFKWKNAVGEGISDYEVKYYKGLGTSSAKEGREYFENIDRHRLNFVY 659

Query: 116 RNDEDLDAINIAFSKSKTRERRGLMLKFKSSDYR----DYTDLSICYKDFLQKEFILYSM 171
            + +D D+I +AF+K K  ER+  +++  SS  R     Y    + Y +F+ KE IL+S+
Sbjct: 660 EDRKDDDSIVLAFAKDKVDERKRWVMESMSSARRFESLSYNARDVSYSEFVHKELILFSV 719

Query: 172 ASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTL 231
           A   R IPS++DG KP QRKI++ AFKR L   ++V +  GYV+EH+AYHH E SL  T+
Sbjct: 720 ADCERSIPSVVDGLKPGQRKIMFSAFKRNLVRSLKVARFAGYVSEHAAYHHGEQSLVQTI 779

Query: 232 MRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKY 291
           + +A+DYVG+ N+ LL  +GQFGT +QGGKDHA+ RYI T L  I+R ++   D+ +++Y
Sbjct: 780 VGLAQDYVGANNVPLLYRDGQFGTRLQGGKDHAAGRYISTRLTDIARRIYHPSDDFIVEY 839

Query: 292 LNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPM 351
            ++DG+SVEP +Y+P+IP+VLVNG +GI TG+  +IP Y+P D+I N+ R L+ ++LQPM
Sbjct: 840 RDDDGLSVEPFYYVPVIPMVLVNGTAGIGTGFATNIPNYSPLDVIDNLNRLLSGEELQPM 899

Query: 352 VPWYKGFKGTIDKSIGG 368
            PWY GF GTI++   G
Sbjct: 900 KPWYFGFTGTIEEREKG 916


>D0A927_TRYB9 (tr|D0A927) DNA topoisomerase 2 OS=Trypanosoma brucei gambiense
           (strain MHOM/CI/86/DAL972) GN=TbgDal_XI12970 PE=3 SV=1
          Length = 1465

 Score =  363 bits (931), Expect = 8e-98,   Method: Compositional matrix adjust.
 Identities = 177/377 (46%), Positives = 259/377 (68%), Gaps = 10/377 (2%)

Query: 2   ESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCN 58
           E   YG +M M+DQD+DGSHIKGL+IN  +   P LL++P FL + ITPI++A      N
Sbjct: 540 EGLRYGHLMIMSDQDHDGSHIKGLIINMIHNYWPDLLKVPGFLQQFITPIVKARKKGRGN 599

Query: 59  GIQ-KLSFYSYPEYEKWWKNWGN--SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVW 115
             +  +SF+S P+Y KW    G   SD+ +KYYKGLG+ + +EG+E+F+N++  R  FV+
Sbjct: 600 SDEGTISFFSMPDYFKWKNAVGEGISDYEVKYYKGLGTSSAKEGREYFENIDRHRLNFVY 659

Query: 116 RNDEDLDAINIAFSKSKTRERRGLMLKFKSSDYR----DYTDLSICYKDFLQKEFILYSM 171
            + +D D+I +AF+K K  ER+  +++  SS  R     Y    + Y +F+ KE IL+S+
Sbjct: 660 EDRKDDDSIVLAFAKDKVDERKRWVMESMSSARRFESLSYNARDVSYSEFVHKELILFSV 719

Query: 172 ASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTL 231
           A   R IPS++DG KP QRKI++ AFKR L   ++V +  GYV+EH+AYHH E SL  T+
Sbjct: 720 ADCERSIPSVVDGLKPGQRKIMFSAFKRNLVRSLKVARFAGYVSEHAAYHHGEQSLVQTI 779

Query: 232 MRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKY 291
           + +A+DYVG+ N+ LL  +GQFGT +QGGKDHA+ RYI T L  I+R ++   D+ +++Y
Sbjct: 780 VGLAQDYVGANNVPLLYRDGQFGTRLQGGKDHAAGRYISTRLTDIARRIYHPSDDFIVEY 839

Query: 292 LNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPM 351
            ++DG+SVEP +Y+P+IP+VLVNG +GI TG+  +IP Y+P D+I N+ R L+ ++LQPM
Sbjct: 840 RDDDGLSVEPFYYVPVIPMVLVNGTAGIGTGFATNIPNYSPLDVIDNLNRLLSGEELQPM 899

Query: 352 VPWYKGFKGTIDKSIGG 368
            PWY GF GTI++   G
Sbjct: 900 KPWYFGFTGTIEEREKG 916


>H3D5N4_TETNG (tr|H3D5N4) DNA topoisomerase 2 (Fragment) OS=Tetraodon
           nigroviridis GN=TOP2A PE=3 SV=1
          Length = 1557

 Score =  363 bits (931), Expect = 8e-98,   Method: Compositional matrix adjust.
 Identities = 186/377 (49%), Positives = 250/377 (66%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   F+ E ITPII+A H    
Sbjct: 527 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHKK-- 583

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 584 TQLSFYSIPEFSAWKESQANHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 643

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  + KF  +  +        DY    T   + Y DF+ KE +
Sbjct: 644 DDEAITLAFSKKKVEERKEWLTKFMINRRQRREHNLPEDYLYGQTTKYLSYNDFVNKELV 703

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 704 LFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 763

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+ ++R +FP +D+ 
Sbjct: 764 MMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSSLARLVFPPVDDN 823

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP+VLVNG  GI TGW   IP Y+ ++I+ NI R L+ D+
Sbjct: 824 LLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDIREIVNNIHRMLSGDE 883

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YKGFKGTI++
Sbjct: 884 PLPMLPNYKGFKGTIEQ 900


>H3C592_TETNG (tr|H3C592) DNA topoisomerase 2 (Fragment) OS=Tetraodon
           nigroviridis GN=TOP2A PE=3 SV=1
          Length = 1558

 Score =  362 bits (930), Expect = 9e-98,   Method: Compositional matrix adjust.
 Identities = 186/377 (49%), Positives = 250/377 (66%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   F+ E ITPII+A H    
Sbjct: 528 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHKK-- 584

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 585 TQLSFYSIPEFSAWKESQANHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 644

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  + KF  +  +        DY    T   + Y DF+ KE +
Sbjct: 645 DDEAITLAFSKKKVEERKEWLTKFMINRRQRREHNLPEDYLYGQTTKYLSYNDFVNKELV 704

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 705 LFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 764

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+ ++R +FP +D+ 
Sbjct: 765 MMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSSLARLVFPPVDDN 824

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP+VLVNG  GI TGW   IP Y+ ++I+ NI R L+ D+
Sbjct: 825 LLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDIREIVNNIHRMLSGDE 884

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YKGFKGTI++
Sbjct: 885 PLPMLPNYKGFKGTIEQ 901


>F7BGW3_XENTR (tr|F7BGW3) DNA topoisomerase 2 OS=Xenopus tropicalis GN=top2b PE=3
           SV=1
          Length = 1562

 Score =  362 bits (930), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINFF+   PSLL+   FL E ITPI++A      
Sbjct: 548 LKTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HSFLEEFITPIVKA--TKNK 604

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+E+W K   N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 605 QELSFYSIPEFEEWKKQTENQKLWKIKYYKGLGTSTSKEAKEYFADMDRHRIIFRYAGPE 664

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 665 DDAAITLAFSKKKVDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 723

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 724 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 783

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N++LL   GQFGT + GGKD ASPRYI+T L+P++R L+P +D+
Sbjct: 784 LMMTIVNLAQNFVGSNNVSLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLYPSVDD 843

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIPLVLVNG  GI TGW C +P Y+ ++I+ N+KR L+  
Sbjct: 844 NLLKFLYDDNQRVEPEWYIPIIPLVLVNGAEGIGTGWACKLPNYDTREIVNNVKRMLDGL 903

Query: 347 KLQPMVPWYKGFKGTI 362
              P++P YK FKGTI
Sbjct: 904 DPYPLLPSYKNFKGTI 919


>B0WRP3_CULQU (tr|B0WRP3) DNA topoisomerase 2 OS=Culex quinquefasciatus
           GN=CpipJ_CPIJ010018 PE=3 SV=1
          Length = 1358

 Score =  362 bits (929), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 179/376 (47%), Positives = 252/376 (67%), Gaps = 15/376 (3%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG+VM M DQD DGSHIKGLLINF +   P LLR+P FL E ITPI++A   NG 
Sbjct: 544 LKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNG- 601

Query: 61  QKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++LSF+S PE+E+W     NS  + IKYYKGLG+ T +E KE+FQN+E  R  F +    
Sbjct: 602 EELSFFSLPEFEEWKTETANSHTYNIKYYKGLGTSTSKEAKEYFQNMERHRILFTYDTST 661

Query: 120 DLDAINIAFSKSKTRERRG-LMLKFKSSDYRDYTDL-----------SICYKDFLQKEFI 167
           D DAI +AF+K    +R+  L    + + +R    L           +I YK+F+  E +
Sbjct: 662 DDDAITMAFAKKCVDQRKEWLTAHMEENRHRKLVGLPERYLYTKTTRAISYKEFINLELV 721

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP ++DG KP QRK+++  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 722 LFSNSDNVRSIPCVLDGLKPGQRKVMFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQSL 781

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T ++ ++R +F  +D+ 
Sbjct: 782 CSTIVNLAQNFVGSNNINLLYPGGQFGTRLAGGKDSASPRYIFTMMSALTRLIFHPLDDP 841

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LL+Y  +D   +EP WYLPIIP+VLVNG  GI TGW+  IP +NP+DIIAN++R LN ++
Sbjct: 842 LLEYQYDDNQKIEPLWYLPIIPMVLVNGSEGIGTGWSTKIPLHNPRDIIANLRRMLNGEE 901

Query: 348 LQPMVPWYKGFKGTID 363
            + + PWYK F+G+++
Sbjct: 902 PKVLHPWYKNFRGSVE 917


>F2QWR7_PICP7 (tr|F2QWR7) DNA topoisomerase 2 OS=Komagataella pastoris (strain
           ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 /
           Wegner 21-1) GN=PP7435_Chr3-0893 PE=3 SV=1
          Length = 1312

 Score =  362 bits (929), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 179/368 (48%), Positives = 250/368 (67%), Gaps = 6/368 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG +M M DQD+DGSHIKGL+INF     P LL++P FL E ITPI++    +G 
Sbjct: 578 INSLRYGHIMIMTDQDHDGSHIKGLIINFLESSFPGLLKVPNFLLEFITPIVKVTITSGP 637

Query: 61  QK---LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
           +K   + FYS PEYE W +      ++ KYYKGLG+   EE +E+F  ++   K F    
Sbjct: 638 EKRKVIPFYSMPEYEAW-REQNTESFKQKYYKGLGTSLAEEMREYFSQLDKHMKTFHALQ 696

Query: 118 DEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSIC-YKDFLQKEFILYSMASVRR 176
           D D   I++AFSK K  +R+  +  F+   + D  DLSI    DF+ KE IL+SMA   R
Sbjct: 697 DVDPGFIDLAFSKKKADDRKEWLRGFEPGVHLD-PDLSIIPISDFINKELILFSMADNIR 755

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            IPS++DG KPSQRKILYG +KR L +EI+V +L GY+ EHSAYHH + SL  +++ +A+
Sbjct: 756 SIPSMLDGFKPSQRKILYGCYKRNLRSEIKVSQLAGYIGEHSAYHHGDQSLIQSIIGLAQ 815

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           D+VGS N+NLL   G FG+  QGGKD ++ RYI+T+L+ I+R +F   DN LL YL +D 
Sbjct: 816 DFVGSNNLNLLQPIGGFGSRAQGGKDASAARYIFTDLSKITRKIFHVDDNPLLNYLQDDE 875

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYK 356
            +VEPEWYLPI+P++L+NG  GI TGW+ +IP +NP DI+ANI+R ++  +++ M+PWY+
Sbjct: 876 QTVEPEWYLPIVPMLLINGSEGIGTGWSTNIPPFNPVDIVANIRRLMDGQEMEEMIPWYR 935

Query: 357 GFKGTIDK 364
           G+ G+I K
Sbjct: 936 GWNGSITK 943


>A0C7Z3_PARTE (tr|A0C7Z3) DNA topoisomerase 2 OS=Paramecium tetraurelia
           GN=GSPATT00036041001 PE=3 SV=1
          Length = 1220

 Score =  362 bits (929), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 174/368 (47%), Positives = 247/368 (67%), Gaps = 2/368 (0%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG VM M DQD DGSHIKGL+INF +   PSLL+   FL E +TP+I+A    G 
Sbjct: 487 LKSLRYGSVMIMTDQDIDGSHIKGLIINFIHHFWPSLLKYKGFLKEFVTPLIKA--TKGN 544

Query: 61  QKLSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
           Q + F++  ++ K+ +      W+IKYYKGLG+    E +E+F+N+      F + N+ED
Sbjct: 545 QTIPFFTVQDFNKFAQIQDIKSWKIKYYKGLGTSDDLEAQEYFRNLISHTIQFRYDNEED 604

Query: 121 LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
             +I++ F+K K  +R+  + ++    Y D+T   + Y+DF+ KE I +SMA   R IPS
Sbjct: 605 DQSIDLCFNKKKANDRKQWLAQYNHDLYVDHTQKELGYQDFIHKELIHFSMADNIRSIPS 664

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KP QRK+L+  FKR L  EI+V +L GY+AEHSAYHH + SL TT++ MA+++VG
Sbjct: 665 LMDGLKPGQRKVLFACFKRNLKQEIKVVQLGGYIAEHSAYHHGDISLVTTIIGMAQNFVG 724

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL+  GQFG+   GGKDHAS RYI T LN I+R++FPE D+ ++KY+ +DG  VE
Sbjct: 725 SNNINLLLPRGQFGSRAMGGKDHASARYISTVLNKITRYIFPEQDDHVVKYIEDDGEMVE 784

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PE+Y+PIIP+ LVNG  GI TGW+ SI  YNP +++  IK+ LN ++   + P+Y+ F G
Sbjct: 785 PEYYVPIIPMSLVNGAEGIGTGWSTSIQNYNPVELVEQIKKRLNGEQFDNLTPYYRNFDG 844

Query: 361 TIDKSIGG 368
            I+    G
Sbjct: 845 NIETQPNG 852


>I3JVT3_ORENI (tr|I3JVT3) DNA topoisomerase 2 OS=Oreochromis niloticus
           GN=LOC100702932 PE=3 SV=1
          Length = 1629

 Score =  362 bits (929), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 186/376 (49%), Positives = 246/376 (65%), Gaps = 17/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + +  YG++M M DQD DGSHIKGLLINFF+   PSLL+   FL E ITPI++A      
Sbjct: 552 LRTLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HTFLEEFITPIVKA--TKNK 608

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYK-GLGSFTHEEGKEFFQNVEIQRKYFVWRND 118
           Q+L+FYS PE+++W K+  N   W IKYYK GLG+ T +E KE+F ++E  R  F +   
Sbjct: 609 QELAFYSIPEFDEWKKHTENYKTWHIKYYKAGLGTSTSKEAKEYFADMEKHRITFRYTGA 668

Query: 119 EDLDAINIAFSKSKTRERRGLMLKF-KSSDYRDYTDLS-----------ICYKDFLQKEF 166
           ED  AI +AFSK KT +R+  +  F +    R    L            + Y DF+ KE 
Sbjct: 669 EDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTHARHLSYNDFINKEL 728

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 729 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQA 788

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+N+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP +D+
Sbjct: 789 LMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDS 848

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ NI R LN  
Sbjct: 849 NLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQ 908

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKG I
Sbjct: 909 DPLPMLPSYKNFKGVI 924


>B9WF18_CANDC (tr|B9WF18) DNA topoisomerase 2 OS=Candida dubliniensis (strain
           CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL
           Y-17841) GN=TOP2 PE=3 SV=1
          Length = 1461

 Score =  362 bits (929), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 175/368 (47%), Positives = 244/368 (66%), Gaps = 5/368 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPII----RAFH 56
           ++S  YG +M M DQD DGSHIKGL+INF     P LL IP FL E ITPI+    RA  
Sbjct: 570 IKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLEFITPIVKVTVRARG 629

Query: 57  CNGIQKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVW 115
             G + + FY+ PE+E W    G    W  KYYKGLG+ T  E +E+F  ++   K F  
Sbjct: 630 AGGKRVIPFYTMPEFEHWRDTEGKQCRWTQKYYKGLGTSTPMEAREYFTALDRHLKRFHA 689

Query: 116 RNDEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVR 175
              ED + I++AFSK K  ER+  +  F    + D     I   DF+ KE IL+SM+   
Sbjct: 690 LQGEDKNYIDLAFSKKKADERKEWLQGFLPGTHLDPEITEIPISDFINKELILFSMSDNV 749

Query: 176 RCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMA 235
           R IPS++DG KP QRK+LYG FK++L +EI+V +L GYV+E++ YHH E SL  T++ +A
Sbjct: 750 RSIPSVLDGFKPGQRKVLYGCFKKKLRSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLA 809

Query: 236 RDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNED 295
           ++++GS NIN+L  NG FG+   GGKD ++ RYI+TEL+ I+R +F  +D+ L  Y+ +D
Sbjct: 810 QNFIGSNNINVLKPNGSFGSRAAGGKDFSAARYIFTELSEITRKIFNPLDDPLYTYVQDD 869

Query: 296 GISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWY 355
             +VEPEWYLP++P++LVNG  GI TGW+ +IP YNPKD++ANI+R +N ++LQ M PWY
Sbjct: 870 EQTVEPEWYLPVLPMILVNGAEGIGTGWSTNIPSYNPKDLVANIRRLMNGEELQEMTPWY 929

Query: 356 KGFKGTID 363
           KG+ G ++
Sbjct: 930 KGWGGDLE 937


>K7FJR3_PELSI (tr|K7FJR3) DNA topoisomerase 2 OS=Pelodiscus sinensis GN=TOP2B
           PE=3 SV=1
          Length = 1619

 Score =  362 bits (929), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 544 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKASKSK-- 600

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+L+FYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 601 QELAFYSIPEFDEWKKHMENHKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 660

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 661 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 719

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 720 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 779

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 780 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLLFPAVDD 839

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 840 NLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVRRMLDGL 899

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 900 DPHPMLPNYKNFKGTI 915


>C5FWK9_ARTOC (tr|C5FWK9) DNA topoisomerase 2 OS=Arthroderma otae (strain ATCC
           MYA-4605 / CBS 113480) GN=MCYG_07112 PE=3 SV=1
          Length = 1676

 Score =  362 bits (928), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 172/361 (47%), Positives = 244/361 (67%), Gaps = 4/361 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC---NGIQK 62
           YG +M M DQD+DGSHIKGLLIN+  +  P+LL+IP FL E ITPI++ +     N    
Sbjct: 628 YGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGDPKNPTHS 687

Query: 63  LSFYSYPEYEKWWKNWG-NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            SF++ PEYE+W +    +  W+ KYYKGLG+ + E+ + +FQ+++   K F    D++ 
Sbjct: 688 KSFFTLPEYEEWKETHAHDKKWQKKYYKGLGTSSTEDAQIYFQDLDKHLKQFHTLQDKEA 747

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I +AFSK K  ER+  + +FK   Y D++   I Y DF+ KE IL+SMA   R IPS+
Sbjct: 748 ELIELAFSKKKADERKEWLRQFKPGTYLDHSTEQITYSDFINKELILFSMADNIRSIPSV 807

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           IDG KP QRK+LY  FKR +  +I+V +L GYV+  +AY H ++SL TT++ +A+ +VGS
Sbjct: 808 IDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVGLAQTFVGS 867

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L  +G FG+ +QGG D AS RYIYT L+P +R LF   D  LL    +DG  +EP
Sbjct: 868 NNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHPADEPLLVNNTDDGKVIEP 927

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y+P++PL+L+NG  GI TGW+ SIP YNP+D++AN+KR +  ++L PM PW++GFKG 
Sbjct: 928 ETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVANLKRLMAGEELVPMKPWFRGFKGE 987

Query: 362 I 362
           +
Sbjct: 988 V 988


>M4ARH2_XIPMA (tr|M4ARH2) DNA topoisomerase 2 OS=Xiphophorus maculatus GN=TOP2B
           PE=3 SV=1
          Length = 1598

 Score =  362 bits (928), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 243/376 (64%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + +  YGR+M M DQD DGSHIKGLLINFF+   PSLL+   FL + ITP+++A      
Sbjct: 533 LRTLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKH-TFLEQFITPLVKA--TKNK 589

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+L+FYS PE+E+W K   N   W IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 590 QELAFYSLPEFEEWKKQTENFKTWHIKYYKGLGTSTSKEAKEYFADMERHRITFRYNGAE 649

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK KT +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 650 DDAAITLAFSKKKTDDRKEWLTNF-MEDRRQRRMHGLPEQYLYGTQAKHLSYNDFINKEL 708

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 709 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQA 768

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+N+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP +D 
Sbjct: 769 LMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPSMDF 828

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ NI R L+  
Sbjct: 829 NLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLSHQ 888

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKG I
Sbjct: 889 DPLPMLPSYKNFKGLI 904


>I7IP59_BABMI (tr|I7IP59) DNA topoisomerase 2 OS=Babesia microti strain RI
           GN=BBM_I01220 PE=3 SV=1
          Length = 1309

 Score =  362 bits (928), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 179/365 (49%), Positives = 254/365 (69%), Gaps = 10/365 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQDYDGSHIKGLLIN  +   PSLL+   FL + ITPII+A   N IQ  SF
Sbjct: 511 YGSLMIMTDQDYDGSHIKGLLINLIHQFWPSLLKYRGFLRQFITPIIKATKGN-IQ-TSF 568

Query: 66  YSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAI 124
           Y+  ++ KW     +   WRIKYYKGLG+ T  E KE+F+N++     F WRN+E  + I
Sbjct: 569 YTISDFNKWKDTVQDIRYWRIKYYKGLGTSTDTEFKEYFKNIKDHLIDFKWRNEECDNKI 628

Query: 125 NIAFSKSKTRERR-------GLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRC 177
           ++AF+K +  +R+        +  +  +S   D++   + Y+DF+ KE +L+S+    R 
Sbjct: 629 DMAFNKKRVEDRKRWLQNHVAMQEEGVASLGVDHSCKELSYQDFVDKELVLFSIYDTERS 688

Query: 178 IPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARD 237
           IPS++DG KP QRK+L+G FKR L TE +V +L GY+AEHSAYHH E+SL  T++ MA+ 
Sbjct: 689 IPSIMDGLKPGQRKVLFGCFKRNLRTECKVAQLTGYIAEHSAYHHGETSLQQTIINMAQT 748

Query: 238 YVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGI 297
           +VGS NINLL   GQFG+  +GGKD ++ RYI+T+L+ ++R ++  ID+ +L+Y  E+G 
Sbjct: 749 FVGSNNINLLEPCGQFGSRKEGGKDASAARYIFTKLSELTRLIYHPIDDAILEYQTEEGQ 808

Query: 298 SVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKG 357
           S+EP +Y+PI+P+VLVNG  GI TG++ +IP ++P DIIANIKR++ND+ L PM PW+KG
Sbjct: 809 SIEPIFYIPILPMVLVNGCEGIGTGFSSTIPNFSPFDIIANIKRYINDEMLIPMTPWFKG 868

Query: 358 FKGTI 362
           FKG+I
Sbjct: 869 FKGSI 873


>B6QAM9_PENMQ (tr|B6QAM9) DNA topoisomerase 2 OS=Penicillium marneffei (strain
           ATCC 18224 / CBS 334.59 / QM 7333) GN=PMAA_064030 PE=3
           SV=1
          Length = 1696

 Score =  362 bits (928), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 170/361 (47%), Positives = 247/361 (68%), Gaps = 4/361 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC---NGIQK 62
           YG +M M DQD+DGSHIKGLLINF  +  PSLL+IP FL E ITPII+ +     N  + 
Sbjct: 631 YGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPEFLIEFITPIIKVWKGDPKNPTKS 690

Query: 63  LSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            SF++ PEYE+W  +N  +  W+ KYYKGLG+ T E+ + +F++++   K F    D + 
Sbjct: 691 KSFFTMPEYEQWKEENKNDLSWQHKYYKGLGTSTTEDAQIYFRDLDRHLKEFHTMQDHEA 750

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
             I++AFSK K  ER+  + ++K   + D++   I Y DF+ KE IL+SMA  +R IPS+
Sbjct: 751 QLIDLAFSKKKADERKEWLRQYKPGTFLDHSTKQITYTDFINKELILFSMADNQRSIPSV 810

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KP QRK+LY  FKR L  +++V +L G+V+  +AY H E+SL  T++ +A+ +VGS
Sbjct: 811 VDGLKPGQRKVLYTCFKRNLKKDMKVVELAGHVSGMTAYQHGETSLQQTIVGLAQTFVGS 870

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+N L  +G FG+ +QGG D AS RYIYT L+P +R +F + D  LL Y  +DG  +EP
Sbjct: 871 NNLNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFNQQDEPLLTYNEDDGEKIEP 930

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y+P++PL+L+NG  GI TGW+ SIP YNP+DI+AN+KR ++ ++ +PM PW++GF G 
Sbjct: 931 ELYVPVVPLILINGADGIGTGWSSSIPNYNPEDIVANLKRMMDGEEPEPMQPWFRGFNGE 990

Query: 362 I 362
           +
Sbjct: 991 V 991


>Q6CTC1_KLULA (tr|Q6CTC1) DNA topoisomerase 2 OS=Kluyveromyces lactis (strain
           ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL
           Y-1140 / WM37) GN=KLLA0C13838g PE=3 SV=1
          Length = 1435

 Score =  362 bits (928), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 173/361 (47%), Positives = 243/361 (67%), Gaps = 2/361 (0%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIR-AFHCNGIQKLS 64
           YG +M M DQD+DGSHIKGL+INF     P LL IP FL E ITPII+        + +S
Sbjct: 522 YGHIMIMTDQDHDGSHIKGLIINFLESSFPGLLDIPGFLIEFITPIIKITISRPKKETIS 581

Query: 65  FYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           FY+ P+YEKW +   +   W+ KYYKGLG+ T +E +E+F  ++   K F     +D   
Sbjct: 582 FYNMPDYEKWREEESHKYTWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQL 641

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLID 183
           I++AFSK K  +R+  +  ++     D     I   DF+ KE IL+S+A   R IPS++D
Sbjct: 642 IDLAFSKKKADDRKEWLKLYEPGTVLDPKLTEIPISDFINKELILFSLADNIRSIPSVLD 701

Query: 184 GQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMN 243
           G KP QRK++Y  FKR L +EI+V +L GYV+EH+ YHH E SL  T++ +A+D+VGS N
Sbjct: 702 GLKPGQRKVIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNN 761

Query: 244 INLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEW 303
           I LL  NG FGT   GGKD A+PRYI+TELN ++R +F  +D+ LL Y+ +D  +VEPEW
Sbjct: 762 IYLLKPNGAFGTRATGGKDSAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEW 821

Query: 304 YLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTID 363
           YLP+IP+VLVNG  GI TGW+ +IP +NP DI+ N+KR +  ++++ M PWY+G++G+++
Sbjct: 822 YLPVIPMVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLE 881

Query: 364 K 364
           K
Sbjct: 882 K 882


>H3A5L5_LATCH (tr|H3A5L5) DNA topoisomerase 2 OS=Latimeria chalumnae PE=3 SV=1
          Length = 1401

 Score =  361 bits (927), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 183/376 (48%), Positives = 246/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 331 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HNFLEEFITPIVKA--TKNK 387

Query: 61  QKLSFYSYPEYEKWWKNW-GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+L+FYS PE+++W K    +  WRIKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 388 QELAFYSIPEFDEWKKQTETHKSWRIKYYKGLGTSTAKEAKEYFADMERHRILFRYGGPE 447

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 448 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQYLYGTATKHLTYNDFINKEL 506

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 507 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCCKRNDKREVKVAQLAGSVAEMSAYHHGEQA 566

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 567 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLTRLLFPPVDD 626

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
           +LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ N++R L+  
Sbjct: 627 QLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVVNVRRMLDGQ 686

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK +KG I
Sbjct: 687 DPLPMLPSYKSYKGII 702


>H0YVT8_TAEGU (tr|H0YVT8) DNA topoisomerase 2 OS=Taeniopygia guttata GN=TOP2A
           PE=3 SV=1
          Length = 1543

 Score =  361 bits (927), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 180/384 (46%), Positives = 254/384 (66%), Gaps = 30/384 (7%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A      
Sbjct: 528 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKA--SKNK 584

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++++FYS PE+E+W  +  N + W+IKYYKGLG+ T +E KE+F ++   R  F +   E
Sbjct: 585 EEIAFYSIPEFEEWKASTQNYNSWKIKYYKGLGTSTSKEAKEYFADMAKHRIGFKYSGPE 644

Query: 120 DLDAINIAFSKSKTRERRGLMLKF-------------------KSSDYRDYTDLSICYKD 160
           D  AI +AFSK K  ER+  +  F                   K++DY       + Y D
Sbjct: 645 DDAAITLAFSKKKIEERKEWLTNFMEDRRQRKLHGLPEEYLYGKNTDY-------LTYND 697

Query: 161 FLQKEFILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAY 220
           F+ KE +L+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE S+Y
Sbjct: 698 FINKELVLFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSY 757

Query: 221 HHDESSLATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFL 280
           HH E++L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R +
Sbjct: 758 HHGEAALMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLV 817

Query: 281 FPEIDNKLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIK 340
           FP +D+ +L++L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP ++ ++++ NI+
Sbjct: 818 FPPMDDNILRFLYDDNQRVEPEWYMPIIPMVLVNGAEGIGTGWACKIPNFDIREVVNNIR 877

Query: 341 RFLNDDKLQPMVPWYKGFKGTIDK 364
           R ++ ++  PM+P YK FKGTID+
Sbjct: 878 RLMDGEEPLPMLPSYKNFKGTIDE 901


>F1KQW9_ASCSU (tr|F1KQW9) DNA topoisomerase 2 OS=Ascaris suum PE=2 SV=1
          Length = 1560

 Score =  361 bits (927), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 176/377 (46%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG+VM MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 526 MKTLRYGKVMVMADQDQDGSHIKGLVINFIHFNWPALIR-RNFVEEFITPIVKA--TKGK 582

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++ SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +   +
Sbjct: 583 EEFSFFSLPEYAEWRNNTENWKSYRIKYYKGLGTSTSKEAKEYFTDMARHRIRFRYGGQD 642

Query: 120 DLDAINIAFSKSKTRERR----GLMLKFKSSDYRDYTDL--------SICYKDFLQKEFI 167
           D  ++++AFSK +  +R+      M + K+   +  T+         ++ +KDF+ KE +
Sbjct: 643 DDMSLDMAFSKKRIEDRKTWLTSWMAERKNRREQGLTEEYLYDKDTHTVSFKDFVNKELV 702

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S     R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 703 LFSNLDNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 762

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP +D  
Sbjct: 763 MATIINLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSVDES 822

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  +P YNP++I+ NI+  +  ++
Sbjct: 823 VLRFLYEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKVPNYNPREIVENIRLMIRGEQ 882

Query: 348 LQPMVPWYKGFKGTIDK 364
            + MVPW+K F+GTI++
Sbjct: 883 PRHMVPWFKNFRGTIEQ 899


>F0ZNB2_DICPU (tr|F0ZNB2) DNA topoisomerase 2 (Fragment) OS=Dictyostelium
           purpureum GN=DICPUDRAFT_4475 PE=3 SV=1
          Length = 1162

 Score =  361 bits (927), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 180/364 (49%), Positives = 244/364 (67%), Gaps = 4/364 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M M DQD DGSHIKGL+INF +   P LL +P FL E ITPI++    NG   +SF
Sbjct: 500 YGHLMIMTDQDNDGSHIKGLIINFIHHFWPQLLHMPGFLVEFITPIVKVSK-NGKNAISF 558

Query: 66  YSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDAIN 125
           Y+ PE+ +W +      W IKYYKGLG+    EGKE+F ++E  +  F W +  D  +I+
Sbjct: 559 YTLPEFLEW-REKNPKGWDIKYYKGLGTSQASEGKEYFSDLEKHKIDFEWDDKADT-SID 616

Query: 126 IAFSKSKTRERRGLMLKFKSSDY-RDYTDLSICYKDFLQKEFILYSMASVRRCIPSLIDG 184
           +AFSKSK  ER+  M +     Y   Y    + Y DF+ KE IL+S+A   R IPS++DG
Sbjct: 617 LAFSKSKADERKKWMAEHVEGTYLEQYGVGKLSYTDFINKELILFSIADCERSIPSIVDG 676

Query: 185 QKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSMNI 244
            K SQRKILY  FKR L  EI+V +LIGYV+EHSAYHH E SL +T++ MA++Y+GS N 
Sbjct: 677 LKTSQRKILYSCFKRNLKKEIKVAQLIGYVSEHSAYHHGEMSLYSTILGMAQEYIGSNNA 736

Query: 245 NLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPEWY 304
           NLL  +G +GT IQGGKD +S RYI+T L  ++R L+   D+ +L  + +DG  V+P+ Y
Sbjct: 737 NLLYPSGAYGTRIQGGKDASSARYIHTRLTDVARALYHPDDDNILACVVDDGKKVQPKHY 796

Query: 305 LPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTIDK 364
           +PIIP++LVNG  GI TGW+ +IP YNP+D++ N+K  LN  +L+P+ PWY+GF G I +
Sbjct: 797 IPIIPMILVNGTVGIGTGWSTTIPSYNPRDLVENMKLLLNKQELKPIQPWYRGFTGEILE 856

Query: 365 SIGG 368
           S  G
Sbjct: 857 SGKG 860


>Q5A1E7_CANAL (tr|Q5A1E7) DNA topoisomerase 2 OS=Candida albicans (strain SC5314
           / ATCC MYA-2876) GN=TOP2 PE=3 SV=1
          Length = 1461

 Score =  361 bits (926), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 175/368 (47%), Positives = 243/368 (66%), Gaps = 5/368 (1%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIR----AFH 56
           ++S  YG +M M DQD DGSHIKGL+INF     P LL IP FL E ITPI++    A  
Sbjct: 570 IKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLEFITPIVKVTVKARG 629

Query: 57  CNGIQKLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVW 115
             G + + FY+ PE+E W    G    W  KYYKGLG+ T  E +E+F  ++   K F  
Sbjct: 630 AGGKRVIPFYTMPEFEHWRDTEGKQCRWTQKYYKGLGTSTPMEAREYFTALDRHLKRFHA 689

Query: 116 RNDEDLDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVR 175
              ED D I++AFSK K  ER+  +  F    + D     I   DF+ KE IL+SM+   
Sbjct: 690 LQGEDKDYIDLAFSKKKADERKEWLQGFLPGTHLDPEITEIPISDFINKELILFSMSDNV 749

Query: 176 RCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMA 235
           R IPS++DG KP QRK+LYG FK++L +EI+V +L GYV+E++ YHH E SL  T++ +A
Sbjct: 750 RSIPSVLDGFKPGQRKVLYGCFKKKLRSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLA 809

Query: 236 RDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNED 295
           +++VGS NIN+L  NG FG+   GGKD ++ RYI+TEL+ I+R +F  +D+ L  Y+ +D
Sbjct: 810 QNFVGSNNINVLKPNGSFGSRAAGGKDFSAARYIFTELSEITRKIFNPLDDPLYTYVQDD 869

Query: 296 GISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWY 355
             +VEPEWYLP++P++LVNG  GI TGW+ +IP YNPKD++ NI+R +N ++LQ M PWY
Sbjct: 870 EQTVEPEWYLPVLPMILVNGAEGIGTGWSTNIPSYNPKDLVTNIRRLMNGEELQEMTPWY 929

Query: 356 KGFKGTID 363
           KG+ G ++
Sbjct: 930 KGWGGDLE 937


>R0L0H5_ANAPL (tr|R0L0H5) DNA topoisomerase 2-alpha (Fragment) OS=Anas
           platyrhynchos GN=Anapl_12185 PE=4 SV=1
          Length = 1568

 Score =  361 bits (926), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 180/377 (47%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   FL E ITPII+A      
Sbjct: 544 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKA--SKNK 600

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++++FYS PE+E+W  +  N + W+IKYYKGLG+ T +E KE+F ++   R  F +   E
Sbjct: 601 EEIAFYSIPEFEEWKNSTQNYNSWKIKYYKGLGTSTSKEAKEYFADMAKHRIGFKYSGPE 660

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKS-----------SDYRDYTDLS-ICYKDFLQKEFI 167
           D  AI +AFSK K  ER+  +  F              +Y    D + + Y DF+ KE +
Sbjct: 661 DDAAITLAFSKKKVEERKEWLTNFMEDRRQRKLHGLPEEYLYGKDTNYLTYNDFINKELV 720

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE S+YHH E+SL
Sbjct: 721 LFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEASL 780

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+ 
Sbjct: 781 MMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPMDDN 840

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +LK+L +D   VEPEWY+PIIP+VL+NG  GI TGW+C IP ++ ++ + NI+R ++ ++
Sbjct: 841 VLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDIRETVNNIRRLMDGEE 900

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YK FKGTID+
Sbjct: 901 PLPMLPSYKNFKGTIDE 917


>F1KQW6_ASCSU (tr|F1KQW6) DNA topoisomerase 2 OS=Ascaris suum PE=2 SV=1
          Length = 1514

 Score =  361 bits (926), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 176/377 (46%), Positives = 253/377 (67%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG+VM MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 526 MKTLRYGKVMVMADQDQDGSHIKGLVINFIHFNWPALIR-RNFVEEFITPIVKA--TKGK 582

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           ++ SF+S PEY +W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +   +
Sbjct: 583 EEFSFFSLPEYAEWRNNTENWKSYRIKYYKGLGTSTSKEAKEYFTDMARHRIRFRYGGQD 642

Query: 120 DLDAINIAFSKSKTRERR----GLMLKFKSSDYRDYTDL--------SICYKDFLQKEFI 167
           D  ++++AFSK +  +R+      M + K+   +  T+         ++ +KDF+ KE +
Sbjct: 643 DDMSLDMAFSKKRIEDRKTWLTSWMAERKNRREQGLTEEYLYDKDTHTVSFKDFVNKELV 702

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S     R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 703 LFSNLDNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 762

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+DYVGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP +D  
Sbjct: 763 MATIINLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSVDES 822

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY PIIP VLVNG  GI T W+  +P YNP++I+ NI+  +  ++
Sbjct: 823 VLRFLYEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKVPNYNPREIVENIRLMIRGEQ 882

Query: 348 LQPMVPWYKGFKGTIDK 364
            + MVPW+K F+GTI++
Sbjct: 883 PRHMVPWFKNFRGTIEQ 899


>K9IV03_DESRO (tr|K9IV03) DNA topoisomerase 2 (Fragment) OS=Desmodus rotundus
           PE=2 SV=1
          Length = 1603

 Score =  361 bits (926), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 526 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 582

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 583 QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 642

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 643 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 701

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 702 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 761

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 762 LMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARRLFPAVDD 821

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VL+NG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 822 NLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGL 881

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 882 DPHPMLPNYKNFKGTI 897


>H3A5L4_LATCH (tr|H3A5L4) DNA topoisomerase 2 (Fragment) OS=Latimeria chalumnae
           PE=3 SV=1
          Length = 1615

 Score =  361 bits (926), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 183/376 (48%), Positives = 246/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           ++S  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 539 LKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HNFLEEFITPIVKA--TKNK 595

Query: 61  QKLSFYSYPEYEKWWKNW-GNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+L+FYS PE+++W K    +  WRIKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 596 QELAFYSIPEFDEWKKQTETHKSWRIKYYKGLGTSTAKEAKEYFADMERHRILFRYGGPE 655

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 656 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQYLYGTATKHLTYNDFINKEL 714

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 715 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCCKRNDKREVKVAQLAGSVAEMSAYHHGEQA 774

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 775 LMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLTRLLFPPVDD 834

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
           +LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+P++I+ N++R L+  
Sbjct: 835 QLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVVNVRRMLDGQ 894

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK +KG I
Sbjct: 895 DPLPMLPSYKSYKGII 910


>G1XKF5_ARTOA (tr|G1XKF5) DNA topoisomerase 2 OS=Arthrobotrys oligospora (strain
            ATCC 24927 / CBS 115.81 / DSM 1491) GN=AOL_s00109g184
            PE=3 SV=1
          Length = 1586

 Score =  360 bits (925), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 171/362 (47%), Positives = 240/362 (66%), Gaps = 3/362 (0%)

Query: 6    YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFH---CNGIQK 62
            YG +M M DQD+DGSHIKGLLINF      SLL+I  FL E ITPI++A+        + 
Sbjct: 643  YGHLMIMTDQDHDGSHIKGLLINFLDAQFASLLKIDGFLLEFITPIVKAYKGVVTKPTKS 702

Query: 63   LSFYSYPEYEKWWKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLD 122
             +F++ PEYE+W +      W+ KYYKGLG+ +  E KE+F +++   K F     E+  
Sbjct: 703  RAFFTMPEYEEWKETNTEKGWQTKYYKGLGTSSSAEAKEYFSDLDKHLKEFHSMKLEERG 762

Query: 123  AINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSLI 182
             I++ FSK K  ER+  + +++   Y D++   I Y DF+ KE IL+SMA   R IPS I
Sbjct: 763  LIDMVFSKKKIEERKEWLRQYRPGVYLDHSIEKISYDDFINKELILFSMADNIRSIPSAI 822

Query: 183  DGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGSM 242
            DG KP QRK+L+G FK++L  E++V  L GYV +H+ Y H + SLA T++ +A+ +VGS 
Sbjct: 823  DGLKPGQRKVLFGCFKKKLSKEVKVQSLAGYVLDHTHYQHGDVSLAQTIIALAQTFVGSN 882

Query: 243  NINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEPE 302
            N+N+L   G FG+ + GGKD AS RYI T L+P +R LFP  D+ +L+Y  EDG  +EP 
Sbjct: 883  NVNILEPIGNFGSRLGGGKDAASARYISTMLSPFARALFPAADDAILEYNYEDGDKIEPN 942

Query: 303  WYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGTI 362
            WY P++PL+L+NG  GI TGW+ SIP YNP+D+  NI+R L+D  L+PM PWY+GFKG +
Sbjct: 943  WYAPVLPLILMNGSDGIGTGWSSSIPNYNPEDVAMNIRRLLDDQDLEPMQPWYRGFKGRL 1002

Query: 363  DK 364
            ++
Sbjct: 1003 ER 1004


>H3DLE0_TETNG (tr|H3DLE0) DNA topoisomerase 2 (Fragment) OS=Tetraodon
           nigroviridis GN=TOP2B PE=3 SV=1
          Length = 1585

 Score =  360 bits (925), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 185/376 (49%), Positives = 243/376 (64%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           + S  YG++M M DQD DGSHIKGLLINFF+   PSLL+   FL E ITPI++A      
Sbjct: 546 LRSLRYGKIMIMTDQDQDGSHIKGLLINFFHHNWPSLLK-HTFLEEFITPIVKA--TKNK 602

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+++FYS PE+E+W K   N   W IKYYKGLG+ T +E KE+F  +E  R  F +   E
Sbjct: 603 QEVAFYSIPEFEEWKKQTDNYKSWHIKYYKGLGTSTSKEAKEYFAEMEKHRITFRYSGAE 662

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRDY-------------TDLSICYKDFLQKEF 166
           D  AI +AFSK KT +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 663 DDAAITLAFSKKKTDDRKEWLTNF-MEDRRQRRMHGLPEQYLYGSQARHLSYNDFINKEL 721

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+   KR    E++V +L G VAE SAYHH E +
Sbjct: 722 ILFSNSDNERSIPSLVDGLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSAYHHGEQA 781

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS N+N+L   GQFGT I GGKD ASPRYI+T L+P+++ LFP +D+
Sbjct: 782 LMMTIVNLAQNFVGSNNLNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDS 841

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VLVNG  GI TGW C IP Y+ ++I+ NI R L+  
Sbjct: 842 NLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDVREIVNNINRMLSRQ 901

Query: 347 KLQPMVPWYKGFKGTI 362
           +   M+P YKGFKG I
Sbjct: 902 EPLQMLPSYKGFKGVI 917


>E1FWC3_LOALO (tr|E1FWC3) Uncharacterized protein OS=Loa loa GN=LOAG_05201 PE=4
           SV=1
          Length = 729

 Score =  360 bits (925), Expect = 3e-97,   Method: Compositional matrix adjust.
 Identities = 177/382 (46%), Positives = 255/382 (66%), Gaps = 21/382 (5%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           M++  YG++M MADQD DGSHIKGL+INF +   P+L+R   F+ E ITPI++A    G 
Sbjct: 27  MKTLRYGKIMVMADQDQDGSHIKGLVINFIHYNWPALVR-RNFVEEFITPIVKA--TKGK 83

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           +++SF+S PEY++W  N  N   +RIKYYKGLG+ T +E KE+F ++   R  F +  +E
Sbjct: 84  EEISFFSLPEYKEWLNNTENWKTYRIKYYKGLGTSTSKEAKEYFMDMRRHRIQFRYSGEE 143

Query: 120 DLDAINIAFSKSKTRERR----GLMLKFKSSDYRDYTDL--------SICYKDFLQKEFI 167
           D  A+++AFSK K  ER+      M + +S      T+          + +KDF+ KE +
Sbjct: 144 DDQALDMAFSKKKIEERKIWLTNWMAERRSRREDGLTEEYLYDKDTHVVSFKDFVNKELV 203

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S     R IPSL+DG KP QRK+L+  FKR    E++V +L G V E SAYHH E+SL
Sbjct: 204 LFSNCDNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAYHHGEASL 263

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
            +T++ +A+D+VGS NINLL+  GQFGT +QGGKD ASPRYI+T+LNP+++ LFP ID  
Sbjct: 264 MSTIVNLAQDFVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKALFPSIDEN 323

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           +L++L E+   +EPEWY P+IP VLVNG  GI T W+  +PCYNP++I+ N++  ++  +
Sbjct: 324 VLRFLYEENQKIEPEWYCPVIPTVLVNGTEGIGTAWSTKVPCYNPREIVDNMRALIDGKE 383

Query: 348 LQPM-----VPWYKGFKGTIDK 364
            +       +PWYK F+GTI++
Sbjct: 384 PKTFGKKNSIPWYKHFRGTIEQ 405


>B7G2L6_PHATC (tr|B7G2L6) DNA topoisomerase 2 (Fragment) OS=Phaeodactylum
           tricornutum (strain CCAP 1055/1) GN=PHATRDRAFT_52174
           PE=3 SV=1
          Length = 1143

 Score =  360 bits (925), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 173/362 (47%), Positives = 248/362 (68%), Gaps = 8/362 (2%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGIQKLSF 65
           YG +M MADQD DGSHIKGL+INF +   PSLL IP FL + ITPI++     G +  SF
Sbjct: 513 YGHLMIMADQDNDGSHIKGLIINFIHNFWPSLLDIPGFLQQFITPIVKV--SKGQKSQSF 570

Query: 66  YSYPEYEKWWKNWGNSD--WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDLDA 123
           ++ PEYE W ++ G +   W+IKYYKGLG+ T  E KE+F N+++  +          D 
Sbjct: 571 FNLPEYENWLESTGKNGHGWKIKYYKGLGTSTSAEAKEYFSNLDLH-EVLPDTVQSGNDL 629

Query: 124 INIAFSKSKTRERRGLMLKFKSSDYRDYTDLS---ICYKDFLQKEFILYSMASVRRCIPS 180
           I++ F K++  +R+  +       + +Y+++S   + Y +F+ +E+IL+S +   R IP 
Sbjct: 630 IDMVFRKNRVEDRKQWLNAIAKDTFLNYSEVSKEGVMYSEFINREYILFSKSDNERSIPH 689

Query: 181 LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
           L+DG KPSQRKIL+  FKR+L  EI+V +L GYVAEHSAYHH E+SL  T++ MA+++ G
Sbjct: 690 LLDGFKPSQRKILFACFKRKLKGEIKVAQLTGYVAEHSAYHHGEASLQATIVNMAQNFCG 749

Query: 241 SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
           S NINLL  +GQFGT   GGKD AS RYI+T+L PI+R +F   D++LL Y+N+DG++VE
Sbjct: 750 SNNINLLTPSGQFGTRRMGGKDAASARYIFTKLEPITRAIFHPDDDELLSYINDDGVTVE 809

Query: 301 PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
           PE+Y+P+IP++LVNG  GI TGW+ S+  YNP++I+ N++R +  +    M P+Y GFKG
Sbjct: 810 PEYYVPVIPMILVNGADGIGTGWSTSVNNYNPREIVRNLRRKIAGEDFVAMAPFYSGFKG 869

Query: 361 TI 362
            I
Sbjct: 870 EI 871


>Q8X1U1_PENMA (tr|Q8X1U1) DNA topoisomerase 2 (Fragment) OS=Penicillium marneffei
           GN=TOP 2 PE=3 SV=1
          Length = 1162

 Score =  360 bits (925), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 170/361 (47%), Positives = 247/361 (68%), Gaps = 4/361 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC---NGIQK 62
           YG +M M DQD+DGSHIKGLLINF  +  PSLL+IP FL E ITPII+ +     N  + 
Sbjct: 521 YGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPEFLIEFITPIIKVWKGDPKNPTKS 580

Query: 63  LSFYSYPEYEKW-WKNWGNSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            SF++ PEYE+W  +N  +  W+ KYYKGLG+ T E+ + +F++++   K F    D + 
Sbjct: 581 KSFFTMPEYEQWKEENKNDLSWQHKYYKGLGTSTTEDAQIYFRDLDRHLKEFHTMQDHEA 640

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
             I++AFSK K  ER+  + ++K   + D++   I Y DF+ KE IL+SMA  +R IPS+
Sbjct: 641 QLIDLAFSKKKADERKEWLRQYKPGTFLDHSTKQITYTDFINKELILFSMADNQRSIPSV 700

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           +DG KP QRK+LY  FKR L  +++V +L G+V+  +AY H E+SL  T++ +A+ +VGS
Sbjct: 701 VDGLKPGQRKVLYTCFKRNLKKDMKVVELAGHVSGMTAYQHGETSLQQTIVGLAQTFVGS 760

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+N L  +G FG+ +QGG D AS RYIYT L+P +R +F + D  LL Y  +DG  +EP
Sbjct: 761 NNLNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFNQQDEPLLTYNEDDGEKIEP 820

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y+P++PL+L+NG  GI TGW+ SIP YNP+DI+AN+KR ++ ++ +PM PW++GF G 
Sbjct: 821 ELYVPVVPLILINGADGIGTGWSSSIPNYNPEDIVANLKRMMDGEEPEPMQPWFRGFNGE 880

Query: 362 I 362
           +
Sbjct: 881 V 881


>K9IVY4_DESRO (tr|K9IVY4) DNA topoisomerase 2 (Fragment) OS=Desmodus rotundus
           PE=2 SV=1
          Length = 1494

 Score =  360 bits (925), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 417 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 473

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 474 QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 533

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 534 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 592

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 593 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 652

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 653 LMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARRLFPAVDD 712

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VL+NG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 713 NLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGL 772

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 773 DPHPMLPNYKNFKGTI 788


>Q4S4N6_TETNG (tr|Q4S4N6) DNA topoisomerase 2 (Fragment) OS=Tetraodon
           nigroviridis GN=GSTENG00024101001 PE=3 SV=1
          Length = 1345

 Score =  360 bits (924), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 186/377 (49%), Positives = 250/377 (66%), Gaps = 16/377 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLLR   F+ E ITPII+A H    
Sbjct: 567 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHKK-- 623

Query: 61  QKLSFYSYPEYEKWWKNWGN-SDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
            +LSFYS PE+  W ++  N   W+IKYYKGLG+ T +E KE+F +++  R  F +   E
Sbjct: 624 TQLSFYSIPEFSAWKESQANHKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYAGPE 683

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYR--------DY----TDLSICYKDFLQKEFI 167
           D +AI +AFSK K  ER+  + KF  +  +        DY    T   + Y DF+ KE +
Sbjct: 684 DDEAITLAFSKKKVEERKEWLTKFMINRRQRREHNLPEDYLYGQTTKYLSYNDFVNKELV 743

Query: 168 LYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSL 227
           L+S +   R IP L+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E SL
Sbjct: 744 LFSNSDNERSIPCLVDGLKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSL 803

Query: 228 ATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNK 287
             T++ +A+++VGS N+NLL   GQFGT + GGKD ASPRYI+T L+ ++R +FP +D+ 
Sbjct: 804 MMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSSLARLVFPPVDDN 863

Query: 288 LLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDK 347
           LLKY  +D   VEPEWY+PIIP+VLVNG  GI TGW   IP Y+ ++I+ NI R L+ D+
Sbjct: 864 LLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDIREIVNNIHRMLSGDE 923

Query: 348 LQPMVPWYKGFKGTIDK 364
             PM+P YKGFKGTI++
Sbjct: 924 PLPMLPNYKGFKGTIEQ 940


>K9IVG7_DESRO (tr|K9IVG7) DNA topoisomerase 2 (Fragment) OS=Desmodus rotundus
           PE=2 SV=1
          Length = 1639

 Score =  360 bits (924), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 247/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 547 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 603

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 604 QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 663

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 664 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 722

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 723 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 782

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T L+P++R LFP +D+
Sbjct: 783 LMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARRLFPAVDD 842

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VL+NG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 843 NLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGL 902

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 903 DPHPMLPNYKNFKGTI 918


>K3WUW3_PYTUL (tr|K3WUW3) DNA topoisomerase 2 OS=Pythium ultimum GN=PYU1_G008742
           PE=3 SV=1
          Length = 1216

 Score =  360 bits (924), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 180/378 (47%), Positives = 248/378 (65%), Gaps = 18/378 (4%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAF---HCNGIQK 62
           YG+V+ M DQD+DGSHIKGLL N F+   P LL    F+SE ITPII+        G  K
Sbjct: 557 YGKVVIMTDQDHDGSHIKGLLFNLFHTFWPELLESGAFMSEFITPIIKVTPIRKGKGKDK 616

Query: 63  --LSFYSYPEYEKWWKNWGNSD---WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRN 117
             LSF+S PEY +W       D   + IKYYKGLG+ T  EG+E+FQ+++     F W  
Sbjct: 617 GVLSFFSLPEYFEWKSTQSQDDLKQYSIKYYKGLGTSTSAEGREYFQDLDNHIVDFQWTG 676

Query: 118 DEDLDAINIAFSKSKTRERRGLML-KFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRR 176
           D+D DA+++ FSKS+  +R+  +L ++    + D +  S+ Y+DF+ KE I +S A   R
Sbjct: 677 DQDGDALDMVFSKSRAGDRKEWLLNEYAPESFLDTSSGSVSYRDFVNKELIQFSHADNAR 736

Query: 177 CIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMAR 236
            +PS++DG K SQRK+L+   KR+L  E++V +L GY +EH+AYHH E+SL +T++ MA+
Sbjct: 737 SLPSVVDGLKVSQRKVLFACLKRKLTKEVKVAQLAGYCSEHTAYHHGEASLHSTIVNMAQ 796

Query: 237 DYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDG 296
           DYVG+ N+ LL  +GQFGT +QGGKD ASPRYI+T L   +R LFPE D+ LLKY+N+DG
Sbjct: 797 DYVGANNLPLLYPSGQFGTRLQGGKDAASPRYIFTLLQKYTRMLFPEEDDALLKYVNDDG 856

Query: 297 ISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD---------K 347
             VEP  Y+PI+P++LVNG  GI TGW+ SIPC++P  +I N+   L            K
Sbjct: 857 FPVEPVHYVPILPMLLVNGAEGIGTGWSTSIPCFHPIHVIDNLLHLLEAGDAGEDPDAVK 916

Query: 348 LQPMVPWYKGFKGTIDKS 365
           L+ M PW KGF+G I +S
Sbjct: 917 LETMTPWAKGFRGEIHQS 934


>Q8J2R8_ARTOT (tr|Q8J2R8) DNA topoisomerase 2 (Fragment) OS=Arthroderma otae
           GN=top2 PE=3 SV=1
          Length = 1087

 Score =  360 bits (924), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 173/364 (47%), Positives = 245/364 (67%), Gaps = 4/364 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC---NGIQK 62
           YG +M M DQD+DGSHIKGLLIN+  +  P+LL+IP FL E ITPI++ +     N    
Sbjct: 501 YGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGDPKNPTHS 560

Query: 63  LSFYSYPEYEKWWKNWG-NSDWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            SF++ PEYE+W +    +  W+ KYYKGLG+ + E+ + +FQ+++   K F    D++ 
Sbjct: 561 KSFFTLPEYEEWKETHAHDKKWQKKYYKGLGTSSTEDAQIYFQDLDKHLKQFHTLQDKEA 620

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I +AFSK K  ER+  + +FK   Y D++   I Y DF+ KE IL+SMA   R IPS+
Sbjct: 621 ELIELAFSKKKADERKEWLRQFKPGTYLDHSTEQITYSDFINKELILFSMADNIRSIPSV 680

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           IDG KP QRK+LY  FKR +  +I+V +L GYV+  +AY H ++SL TT++ +A+ +VGS
Sbjct: 681 IDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVGLAQTFVGS 740

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            NIN L  +G FG+ +QGG D AS RYIYT L+P +R LF   D  LL    +DG  +EP
Sbjct: 741 NNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHPADEPLLVNNTDDGKVIEP 800

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y+P++PL+L+NG  GI TGW+ SIP YNP+D++AN+KR +  ++L PM PW++GFKG 
Sbjct: 801 ETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVANLKRLMAGEELVPMKPWFRGFKGE 860

Query: 362 IDKS 365
           +  S
Sbjct: 861 VTGS 864


>C5MDS2_CANTT (tr|C5MDS2) DNA topoisomerase 2 OS=Candida tropicalis (strain ATCC
            MYA-3404 / T1) GN=CTRG_03824 PE=3 SV=1
          Length = 1398

 Score =  360 bits (924), Expect = 5e-97,   Method: Compositional matrix adjust.
 Identities = 176/365 (48%), Positives = 240/365 (65%), Gaps = 5/365 (1%)

Query: 6    YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPI----IRAFHCNGIQ 61
            YG +M M DQD DGSHIKGL+INF     P LL IP FL E ITPI    I+       +
Sbjct: 654  YGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLEIPGFLLEFITPIVKVTIKTRGSGNNR 713

Query: 62   KLSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDED 120
             + FY+ PE+E W    G+   W  KYYKGLG+ T  E +E+F  ++   K F     ED
Sbjct: 714  VIPFYTMPEFEAWRDGEGSQCRWTHKYYKGLGTSTPMEAREYFTALDRHLKKFHALQGED 773

Query: 121  LDAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPS 180
               I++AFSK K  ER+  +  F    + D     I   DF+ KE IL+SM+   R IPS
Sbjct: 774  ASYIDLAFSKKKADERKDWLQGFIPGTHLDPEINEIPISDFINKELILFSMSDNIRSIPS 833

Query: 181  LIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVG 240
            ++DG KP QRK+LYG  K++L +EI+V +L GYV+E++ YHH E SL  T++ +A+++VG
Sbjct: 834  VLDGLKPGQRKVLYGCIKKKLKSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLAQNFVG 893

Query: 241  SMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVE 300
            S NIN+L  NG FG+   GGKD ++ RYI+TELN I+R +F  +D+ L  Y+ +D  +VE
Sbjct: 894  SNNINILKPNGSFGSRAAGGKDFSAARYIFTELNEITRKIFNPLDDPLYNYVQDDEQTVE 953

Query: 301  PEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKG 360
            PEWYLP++P++LVNG  GI TGW+ +IP YNPKD++ANIKR +N ++LQ M PWYKG+ G
Sbjct: 954  PEWYLPVLPMILVNGAEGIGTGWSTNIPSYNPKDLVANIKRLMNGEELQEMTPWYKGWDG 1013

Query: 361  TIDKS 365
             I++S
Sbjct: 1014 DIEQS 1018


>A1CUL0_ASPCL (tr|A1CUL0) DNA topoisomerase 2 OS=Aspergillus clavatus (strain
           ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
           GN=ACLA_087000 PE=3 SV=1
          Length = 1735

 Score =  360 bits (923), Expect = 6e-97,   Method: Compositional matrix adjust.
 Identities = 172/367 (46%), Positives = 249/367 (67%), Gaps = 5/367 (1%)

Query: 6   YGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHC---NGIQK 62
           YG +M M DQD+DGSHIKGLLINF     PSLL+IP FL E ITPII+ +     N  ++
Sbjct: 629 YGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGDPKNPTKQ 688

Query: 63  LSFYSYPEYEKWWKNWGNS-DWRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDEDL 121
            SF++ PEYE W +  G+   W  KYYKGLG+ T E+ + +F++++   K F    D + 
Sbjct: 689 RSFFTMPEYEAWKEQHGHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEFHTLQDHET 748

Query: 122 DAINIAFSKSKTRERRGLMLKFKSSDYRDYTDLSICYKDFLQKEFILYSMASVRRCIPSL 181
           + I +AFSK K  ER+  + +FK   + D++   I Y DF+ KE IL+SMA  +R IPS+
Sbjct: 749 ELIELAFSKKKADERKEWLRQFKPGTFLDHSVAKITYTDFINKELILFSMADNQRSIPSV 808

Query: 182 IDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESSLATTLMRMARDYVGS 241
           IDG KP QRK+LY +F+R L  +++V +L G+V+  +AY H ++SL  T++ +A+ +VGS
Sbjct: 809 IDGLKPGQRKVLYVSFRRNLKKDMKVVELAGHVSGMTAYQHGDASLQQTIVGLAQTFVGS 868

Query: 242 MNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDNKLLKYLNEDGISVEP 301
            N+N L  +G FG+ +QGG+D AS RYIYT L+P +R +F   D  LL Y  +DG  +EP
Sbjct: 869 NNVNCLEPSGNFGSRLQGGQDCASARYIYTRLSPFARRMFHPADEPLLTYNVDDGKQIEP 928

Query: 302 EWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDDKLQPMVPWYKGFKGT 361
           E Y+P++PL+L+NG  GI TGW+ SIP YNP+DI+ N+KR ++ + ++PM PW++GF G 
Sbjct: 929 ENYVPVVPLLLINGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGEPIKPMQPWFRGFNGE 988

Query: 362 IDKSIGG 368
           +  +IGG
Sbjct: 989 V-TAIGG 994


>M3X192_FELCA (tr|M3X192) DNA topoisomerase 2 OS=Felis catus GN=TOP2B PE=3 SV=1
          Length = 1542

 Score =  360 bits (923), Expect = 6e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 246/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 468 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 524

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 525 QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 584

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 585 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 643

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 644 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 703

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T L+ +SR LFP +D+
Sbjct: 704 LMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLSRLLFPAVDD 763

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VL+NG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 764 NLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGL 823

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 824 DPHPMLPNYKNFKGTI 839


>G3WB20_SARHA (tr|G3WB20) DNA topoisomerase 2 (Fragment) OS=Sarcophilus harrisii
           GN=TOP2B PE=3 SV=1
          Length = 1609

 Score =  360 bits (923), Expect = 6e-97,   Method: Compositional matrix adjust.
 Identities = 184/376 (48%), Positives = 246/376 (65%), Gaps = 18/376 (4%)

Query: 1   MESFIYGRVMFMADQDYDGSHIKGLLINFFYMLSPSLLRIPYFLSELITPIIRAFHCNGI 60
           +++  YG++M M DQD DGSHIKGLLINF +   PSLL+   FL E ITPI++A      
Sbjct: 537 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKA--SKNK 593

Query: 61  QKLSFYSYPEYEKWWKNWGNSD-WRIKYYKGLGSFTHEEGKEFFQNVEIQRKYFVWRNDE 119
           Q+LSFYS PE+++W K+  N   W+IKYYKGLG+ T +E KE+F ++E  R  F +   E
Sbjct: 594 QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 653

Query: 120 DLDAINIAFSKSKTRERRGLMLKFKSSDYRD-------------YTDLSICYKDFLQKEF 166
           D  AI +AFSK K  +R+  +  F   D R                   + Y DF+ KE 
Sbjct: 654 DDAAITLAFSKKKIDDRKEWLTNF-MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKEL 712

Query: 167 ILYSMASVRRCIPSLIDGQKPSQRKILYGAFKRELFTEIRVDKLIGYVAEHSAYHHDESS 226
           IL+S +   R IPSL+DG KP QRK+L+  FKR    E++V +L G VAE SAYHH E +
Sbjct: 713 ILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQA 772

Query: 227 LATTLMRMARDYVGSMNINLLMANGQFGTHIQGGKDHASPRYIYTELNPISRFLFPEIDN 286
           L  T++ +A+++VGS NINLL   GQFGT + GGKD ASPRYI+T L+ +SR LFP +D+
Sbjct: 773 LMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLSRLLFPSVDD 832

Query: 287 KLLKYLNEDGISVEPEWYLPIIPLVLVNGVSGIATGWNCSIPCYNPKDIIANIKRFLNDD 346
            LLK+L +D   VEPEWY+PIIP+VL+NG  GI TGW C +P Y+ ++I+ N++R L+  
Sbjct: 833 NLLKFLYDDNQRVEPEWYMPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGL 892

Query: 347 KLQPMVPWYKGFKGTI 362
              PM+P YK FKGTI
Sbjct: 893 DPHPMLPNYKNFKGTI 908