Miyakogusa Predicted Gene
- Lj3g3v3359730.2
BLASTP 2.2.25 [Feb-01-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= Lj3g3v3359730.2 tr|I1JZE3|I1JZE3_SOYBN Methylenetetrahydrofolate
reductase OS=Glycine max GN=Gma.2387 PE=3 SV=1,90.32,0,no
description,NULL; MTHFR,Methylenetetrahydrofolate reductase; seg,NULL;
fadh2_euk: methylenetetrah,CUFF.45670.2
(415 letters)
Database: trembl
41,451,118 sequences; 13,208,986,710 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
I1JZE1_SOYBN (tr|I1JZE1) Methylenetetrahydrofolate reductase OS=... 766 0.0
I1JZE2_SOYBN (tr|I1JZE2) Methylenetetrahydrofolate reductase OS=... 765 0.0
I1KG04_SOYBN (tr|I1KG04) Methylenetetrahydrofolate reductase OS=... 762 0.0
I1KG02_SOYBN (tr|I1KG02) Methylenetetrahydrofolate reductase OS=... 762 0.0
I1KG03_SOYBN (tr|I1KG03) Methylenetetrahydrofolate reductase OS=... 762 0.0
B9HG95_POPTR (tr|B9HG95) Methylenetetrahydrofolate reductase OS=... 734 0.0
M5W952_PRUPE (tr|M5W952) Uncharacterized protein OS=Prunus persi... 732 0.0
M1C551_SOLTU (tr|M1C551) Methylenetetrahydrofolate reductase OS=... 725 0.0
B9N8L0_POPTR (tr|B9N8L0) Methylenetetrahydrofolate reductase OS=... 725 0.0
J7EQB2_TOBAC (tr|J7EQB2) Methylenetetrahydrofolate reductase OS=... 725 0.0
J7EPI5_NICTO (tr|J7EPI5) Methylenetetrahydrofolate reductase OS=... 725 0.0
F6I5I7_VITVI (tr|F6I5I7) Methylenetetrahydrofolate reductase OS=... 724 0.0
M1C552_SOLTU (tr|M1C552) Methylenetetrahydrofolate reductase OS=... 724 0.0
A5ATB7_VITVI (tr|A5ATB7) Methylenetetrahydrofolate reductase OS=... 724 0.0
K4C2P8_SOLLC (tr|K4C2P8) Methylenetetrahydrofolate reductase OS=... 723 0.0
J7EPV1_NICTO (tr|J7EPV1) Methylenetetrahydrofolate reductase OS=... 721 0.0
J7EQB1_NICTO (tr|J7EQB1) Methylenetetrahydrofolate reductase OS=... 721 0.0
J7EQ04_NICSY (tr|J7EQ04) Methylenetetrahydrofolate reductase OS=... 720 0.0
J7EPU9_TOBAC (tr|J7EPU9) Methylenetetrahydrofolate reductase OS=... 720 0.0
M0TJL5_MUSAM (tr|M0TJL5) Methylenetetrahydrofolate reductase OS=... 720 0.0
Q10BJ7_ORYSJ (tr|Q10BJ7) Methylenetetrahydrofolate reductase OS=... 717 0.0
A2XNC0_ORYSI (tr|A2XNC0) Methylenetetrahydrofolate reductase OS=... 717 0.0
Q10BJ6_ORYSJ (tr|Q10BJ6) Methylenetetrahydrofolate reductase OS=... 717 0.0
B9STA4_RICCO (tr|B9STA4) Methylenetetrahydrofolate reductase OS=... 715 0.0
M1BBU4_SOLTU (tr|M1BBU4) Methylenetetrahydrofolate reductase OS=... 714 0.0
K4D5E7_SOLLC (tr|K4D5E7) Methylenetetrahydrofolate reductase OS=... 712 0.0
J3LU35_ORYBR (tr|J3LU35) Methylenetetrahydrofolate reductase OS=... 710 0.0
C5WVY7_SORBI (tr|C5WVY7) Methylenetetrahydrofolate reductase OS=... 707 0.0
I1GLP9_BRADI (tr|I1GLP9) Methylenetetrahydrofolate reductase OS=... 704 0.0
N1QRS8_AEGTA (tr|N1QRS8) Putative methylenetetrahydrofolate redu... 703 0.0
R0HRY0_9BRAS (tr|R0HRY0) Uncharacterized protein OS=Capsella rub... 697 0.0
D7LKW5_ARALL (tr|D7LKW5) Methylenetetrahydrofolate reductase OS=... 697 0.0
M7ZYT1_TRIUA (tr|M7ZYT1) Putative methylenetetrahydrofolate redu... 692 0.0
K4AMY6_SETIT (tr|K4AMY6) Methylenetetrahydrofolate reductase OS=... 692 0.0
M4F9A1_BRARP (tr|M4F9A1) Methylenetetrahydrofolate reductase OS=... 688 0.0
M4CTF4_BRARP (tr|M4CTF4) Methylenetetrahydrofolate reductase OS=... 685 0.0
R0FNP9_9BRAS (tr|R0FNP9) Uncharacterized protein OS=Capsella rub... 683 0.0
M4CGR4_BRARP (tr|M4CGR4) Methylenetetrahydrofolate reductase OS=... 680 0.0
D7LWJ5_ARALL (tr|D7LWJ5) Methylenetetrahydrofolate reductase OS=... 680 0.0
F4JAK1_ARATH (tr|F4JAK1) Methylenetetrahydrofolate reductase OS=... 677 0.0
G3C900_PINPS (tr|G3C900) Methylenetetrahydrofolate reductase OS=... 673 0.0
B8LKP0_PICSI (tr|B8LKP0) Methylenetetrahydrofolate reductase OS=... 671 0.0
A6XMY8_TRIMO (tr|A6XMY8) Methylenetetrahydrofolate reductase OS=... 669 0.0
M0RR35_MUSAM (tr|M0RR35) Methylenetetrahydrofolate reductase OS=... 665 0.0
D8RDX1_SELML (tr|D8RDX1) Methylenetetrahydrofolate reductase OS=... 649 0.0
D8QNN7_SELML (tr|D8QNN7) Methylenetetrahydrofolate reductase OS=... 647 0.0
A9U4S7_PHYPA (tr|A9U4S7) Methylenetetrahydrofolate reductase OS=... 642 0.0
A9RW65_PHYPA (tr|A9RW65) Methylenetetrahydrofolate reductase OS=... 640 0.0
M1C550_SOLTU (tr|M1C550) Methylenetetrahydrofolate reductase OS=... 634 e-179
M4CKS5_BRARP (tr|M4CKS5) Methylenetetrahydrofolate reductase OS=... 620 e-175
C6T731_SOYBN (tr|C6T731) Methylenetetrahydrofolate reductase OS=... 583 e-164
I3S0L6_LOTJA (tr|I3S0L6) Methylenetetrahydrofolate reductase OS=... 582 e-164
M0YZ59_HORVD (tr|M0YZ59) Methylenetetrahydrofolate reductase OS=... 506 e-141
D8U7H4_VOLCA (tr|D8U7H4) Methylenetetrahydrofolate reductase OS=... 505 e-140
A8IAY6_CHLRE (tr|A8IAY6) Methylenetetrahydrofolate reductase OS=... 492 e-136
G7IDE3_MEDTR (tr|G7IDE3) Methylenetetrahydrofolate reductase OS=... 473 e-131
L8H1T6_ACACA (tr|L8H1T6) Methylenetetrahydrofolate reductase OS=... 448 e-123
L1IVS6_GUITH (tr|L1IVS6) Methylenetetrahydrofolate reductase OS=... 441 e-121
M2XB69_GALSU (tr|M2XB69) Methylenetetrahydrofolate reductase OS=... 429 e-118
R7Q356_CHOCR (tr|R7Q356) Methylenetetrahydrofolate reductase OS=... 429 e-117
K3WKM9_PYTUL (tr|K3WKM9) Methylenetetrahydrofolate reductase OS=... 428 e-117
I1KG06_SOYBN (tr|I1KG06) Methylenetetrahydrofolate reductase OS=... 427 e-117
J7MPV6_9CHLO (tr|J7MPV6) Methylenetetrahydrofolate reductase OS=... 427 e-117
F0ZME6_DICPU (tr|F0ZME6) Methylenetetrahydrofolate reductase OS=... 427 e-117
D3BTZ2_POLPA (tr|D3BTZ2) Methylenetetrahydrofolate reductase OS=... 426 e-116
F4PLP1_DICFS (tr|F4PLP1) Methylenetetrahydrofolate reductase OS=... 425 e-116
D2V2R1_NAEGR (tr|D2V2R1) Methylenetetrahydrofolate reductase OS=... 421 e-115
Q54X84_DICDI (tr|Q54X84) Methylenetetrahydrofolate reductase OS=... 420 e-115
I0YN51_9CHLO (tr|I0YN51) Methylenetetrahydrofolate reductase OS=... 418 e-114
D8S976_SELML (tr|D8S976) Methylenetetrahydrofolate reductase OS=... 405 e-110
D0N474_PHYIT (tr|D0N474) Methylenetetrahydrofolate reductase OS=... 405 e-110
M1UY35_CYAME (tr|M1UY35) Methylenetetrahydrofolate reductase OS=... 404 e-110
G4YYD3_PHYSP (tr|G4YYD3) Methylenetetrahydrofolate reductase OS=... 402 e-109
H3GAC2_PHYRM (tr|H3GAC2) Methylenetetrahydrofolate reductase OS=... 402 e-109
D8SVM0_SELML (tr|D8SVM0) Methylenetetrahydrofolate reductase OS=... 401 e-109
F0W2Q3_9STRA (tr|F0W2Q3) Methylenetetrahydrofolate reductase OS=... 394 e-107
F4P4P0_BATDJ (tr|F4P4P0) Methylenetetrahydrofolate reductase OS=... 385 e-104
I1BPZ7_RHIO9 (tr|I1BPZ7) Methylenetetrahydrofolate reductase OS=... 377 e-102
K5WIH4_PHACS (tr|K5WIH4) Methylenetetrahydrofolate reductase OS=... 377 e-102
A1C6H3_ASPCL (tr|A1C6H3) Methylenetetrahydrofolate reductase OS=... 377 e-102
J4GI53_FIBRA (tr|J4GI53) Methylenetetrahydrofolate reductase OS=... 377 e-102
D4AYQ9_ARTBC (tr|D4AYQ9) Methylenetetrahydrofolate reductase OS=... 376 e-101
C4JG55_UNCRE (tr|C4JG55) Methylenetetrahydrofolate reductase OS=... 376 e-101
D4DJK8_TRIVH (tr|D4DJK8) Methylenetetrahydrofolate reductase OS=... 376 e-101
F2S694_TRIT1 (tr|F2S694) Methylenetetrahydrofolate reductase OS=... 376 e-101
C5FFF6_ARTOC (tr|C5FFF6) Methylenetetrahydrofolate reductase OS=... 375 e-101
Q2UEQ8_ASPOR (tr|Q2UEQ8) Methylenetetrahydrofolate reductase OS=... 375 e-101
I8TUJ4_ASPO3 (tr|I8TUJ4) Methylenetetrahydrofolate reductase OS=... 375 e-101
B8NG74_ASPFN (tr|B8NG74) Methylenetetrahydrofolate reductase OS=... 375 e-101
E0XYM8_9CHLR (tr|E0XYM8) Methylenetetrahydrofolate reductase OS=... 375 e-101
F2TKH4_AJEDA (tr|F2TKH4) Methylenetetrahydrofolate reductase OS=... 375 e-101
C5GPB7_AJEDR (tr|C5GPB7) Methylenetetrahydrofolate reductase OS=... 375 e-101
C5JE18_AJEDS (tr|C5JE18) Methylenetetrahydrofolate reductase OS=... 375 e-101
A1DH45_NEOFI (tr|A1DH45) Methylenetetrahydrofolate reductase OS=... 375 e-101
F2SQ86_TRIRC (tr|F2SQ86) Methylenetetrahydrofolate reductase OS=... 375 e-101
B0XSG0_ASPFC (tr|B0XSG0) Methylenetetrahydrofolate reductase OS=... 374 e-101
F2PWP0_TRIEC (tr|F2PWP0) Methylenetetrahydrofolate reductase OS=... 373 e-101
D8Q1D9_SCHCM (tr|D8Q1D9) Methylenetetrahydrofolate reductase OS=... 373 e-101
Q0CXY7_ASPTN (tr|Q0CXY7) Methylenetetrahydrofolate reductase OS=... 373 e-101
Q4X140_ASPFU (tr|Q4X140) Methylenetetrahydrofolate reductase OS=... 373 e-101
A8N945_COPC7 (tr|A8N945) Methylenetetrahydrofolate reductase OS=... 372 e-100
G7X5I8_ASPKW (tr|G7X5I8) Methylenetetrahydrofolate reductase OS=... 372 e-100
G3Y2A7_ASPNA (tr|G3Y2A7) Methylenetetrahydrofolate reductase OS=... 372 e-100
A2QCE3_ASPNC (tr|A2QCE3) Methylenetetrahydrofolate reductase OS=... 372 e-100
E6ZP86_SPORE (tr|E6ZP86) Methylenetetrahydrofolate reductase OS=... 371 e-100
F0U6Q8_AJEC8 (tr|F0U6Q8) Methylenetetrahydrofolate reductase OS=... 370 e-100
C0NNE8_AJECG (tr|C0NNE8) Methylenetetrahydrofolate reductase OS=... 370 e-100
C1GYS1_PARBA (tr|C1GYS1) Methylenetetrahydrofolate reductase OS=... 370 e-100
G4TUD6_PIRID (tr|G4TUD6) Methylenetetrahydrofolate reductase OS=... 370 e-100
M5G436_DACSP (tr|M5G436) Methylenetetrahydrofolate reduct OS=Dac... 369 e-100
B6H6J4_PENCW (tr|B6H6J4) Methylenetetrahydrofolate reductase OS=... 369 e-100
E9DEV7_COCPS (tr|E9DEV7) Methylenetetrahydrofolate reductase OS=... 369 1e-99
C5PJM0_COCP7 (tr|C5PJM0) Methylenetetrahydrofolate reductase OS=... 369 1e-99
K9H2D3_PEND1 (tr|K9H2D3) Methylenetetrahydrofolate reductase OS=... 369 1e-99
K9GDB8_PEND2 (tr|K9GDB8) Methylenetetrahydrofolate reductase OS=... 369 1e-99
J3K5S4_COCIM (tr|J3K5S4) Methylenetetrahydrofolate reductase OS=... 369 1e-99
M9M1W1_9BASI (tr|M9M1W1) 5,10-methylenetetrahydrofolate reductas... 369 2e-99
C1G7L7_PARBD (tr|C1G7L7) Methylenetetrahydrofolate reductase OS=... 369 2e-99
C0RZ73_PARBP (tr|C0RZ73) Methylenetetrahydrofolate reductase OS=... 369 2e-99
Q5B0P7_EMENI (tr|Q5B0P7) Methylenetetrahydrofolate reductase OS=... 368 2e-99
Q0GA67_EMEND (tr|Q0GA67) Methylenetetrahydrofolate reductase OS=... 368 2e-99
I4YIV3_WALSC (tr|I4YIV3) Methylenetetrahydrofolate reductase OS=... 367 3e-99
M2R3N4_CERSU (tr|M2R3N4) Methylenetetrahydrofolate reductase OS=... 367 3e-99
R9P122_9BASI (tr|R9P122) Methylenetetrahydrofolate reductase OS=... 367 3e-99
J3Q094_PUCT1 (tr|J3Q094) Methylenetetrahydrofolate reductase OS=... 366 8e-99
Q6CG63_YARLI (tr|Q6CG63) Methylenetetrahydrofolate reductase OS=... 366 9e-99
Q6FU20_CANGA (tr|Q6FU20) Methylenetetrahydrofolate reductase OS=... 365 1e-98
Q4P5K1_USTMA (tr|Q4P5K1) Methylenetetrahydrofolate reductase OS=... 365 2e-98
F8Q5A5_SERL3 (tr|F8Q5A5) Methylenetetrahydrofolate reductase OS=... 364 4e-98
E7RAA3_PICAD (tr|E7RAA3) Methylenetetrahydrofolate reductase OS=... 363 7e-98
J9MTN4_FUSO4 (tr|J9MTN4) Methylenetetrahydrofolate reductase OS=... 363 9e-98
F9FK60_FUSOF (tr|F9FK60) Methylenetetrahydrofolate reductase OS=... 363 9e-98
C5E2N6_LACTC (tr|C5E2N6) Methylenetetrahydrofolate reductase OS=... 362 1e-97
E3JWM7_PUCGT (tr|E3JWM7) Methylenetetrahydrofolate reductase OS=... 362 1e-97
B0CU22_LACBS (tr|B0CU22) Methylenetetrahydrofolate reductase OS=... 362 2e-97
F4RGV4_MELLP (tr|F4RGV4) Methylenetetrahydrofolate reductase OS=... 362 2e-97
N1J4Z8_ERYGR (tr|N1J4Z8) Methylenetetrahydrofolate reductase OS=... 362 2e-97
I2FMK6_USTH4 (tr|I2FMK6) Methylenetetrahydrofolate reductase OS=... 361 3e-97
B9DHL6_ARATH (tr|B9DHL6) Methylenetetrahydrofolate reductase (Fr... 360 4e-97
M5ED31_MALSM (tr|M5ED31) Genomic scaffold, msy_sf_16 OS=Malassez... 360 5e-97
K1XFY5_MARBU (tr|K1XFY5) Methylenetetrahydrofolate reductase OS=... 360 7e-97
J9J1L8_9SPIT (tr|J9J1L8) Methylenetetrahydrofolate reductase OS=... 359 9e-97
I1CMT8_RHIO9 (tr|I1CMT8) Methylenetetrahydrofolate reductase OS=... 359 1e-96
G2WQ21_VERDV (tr|G2WQ21) Methylenetetrahydrofolate reductase OS=... 358 2e-96
L8X3I0_9HOMO (tr|L8X3I0) Methylenetetrahydrofolate reductase OS=... 358 2e-96
N4VAU1_COLOR (tr|N4VAU1) Methylenetetrahydrofolate reductase 1 O... 358 2e-96
C7Z4M2_NECH7 (tr|C7Z4M2) Methylenetetrahydrofolate reductase OS=... 358 2e-96
K3VHJ6_FUSPC (tr|K3VHJ6) Methylenetetrahydrofolate reductase OS=... 358 2e-96
I1RYW1_GIBZE (tr|I1RYW1) Methylenetetrahydrofolate reductase OS=... 358 3e-96
E9ED23_METAQ (tr|E9ED23) Methylenetetrahydrofolate reductase OS=... 357 3e-96
E1Z340_CHLVA (tr|E1Z340) Methylenetetrahydrofolate reductase OS=... 357 5e-96
Q75EA7_ASHGO (tr|Q75EA7) Methylenetetrahydrofolate reductase OS=... 357 5e-96
M9MW94_ASHGS (tr|M9MW94) FAAR170Wp OS=Ashbya gossypii FDAG1 GN=F... 357 5e-96
M1WGQ3_CLAPU (tr|M1WGQ3) Methylenetetrahydrofolate reductase OS=... 356 8e-96
E9END5_METAR (tr|E9END5) Methylenetetrahydrofolate reductase OS=... 356 8e-96
H6C648_EXODN (tr|H6C648) Methylenetetrahydrofolate reductase OS=... 355 2e-95
B3S098_TRIAD (tr|B3S098) Methylenetetrahydrofolate reductase OS=... 355 2e-95
R9AFX7_WALIC (tr|R9AFX7) Methylenetetrahydrofolate reductase 2 O... 355 2e-95
H2ANE8_KAZAF (tr|H2ANE8) Methylenetetrahydrofolate reductase OS=... 354 3e-95
G0S5U9_CHATD (tr|G0S5U9) Methylenetetrahydrofolate reductase OS=... 354 3e-95
K0KJW6_WICCF (tr|K0KJW6) Methylenetetrahydrofolate reductase OS=... 354 4e-95
H2YN67_CIOSA (tr|H2YN67) Methylenetetrahydrofolate reductase (Fr... 354 4e-95
H2YN66_CIOSA (tr|H2YN66) Methylenetetrahydrofolate reductase OS=... 354 4e-95
B0V153_DANRE (tr|B0V153) Methylenetetrahydrofolate reductase OS=... 353 5e-95
G9MZ58_HYPVG (tr|G9MZ58) Methylenetetrahydrofolate reductase OS=... 353 7e-95
Q2H0T7_CHAGB (tr|Q2H0T7) Methylenetetrahydrofolate reductase OS=... 353 8e-95
H1VMU2_COLHI (tr|H1VMU2) Methylenetetrahydrofolate reductase OS=... 353 1e-94
H2S3I1_TAKRU (tr|H2S3I1) Methylenetetrahydrofolate reductase OS=... 353 1e-94
E3QQT1_COLGM (tr|E3QQT1) Methylenetetrahydrofolate reductase OS=... 352 1e-94
G0RA43_HYPJQ (tr|G0RA43) Methylenetetrahydrofolate reductase OS=... 352 1e-94
G2R3H5_THITE (tr|G2R3H5) Methylenetetrahydrofolate reductase OS=... 352 1e-94
R4XG29_9ASCO (tr|R4XG29) Methylenetetrahydrofolate reductase OS=... 352 1e-94
R7YW82_9EURO (tr|R7YW82) Methylenetetrahydrofolate reductase (NA... 352 2e-94
J8Q880_SACAR (tr|J8Q880) Methylenetetrahydrofolate reductase OS=... 352 2e-94
H9MZH5_DANRE (tr|H9MZH5) Methylenetetrahydrofolate reductase OS=... 352 2e-94
G1X9G2_ARTOA (tr|G1X9G2) Methylenetetrahydrofolate reductase OS=... 351 3e-94
M7SPP9_9PEZI (tr|M7SPP9) Putative methylenetetrahydrofolate redu... 351 3e-94
R7UHV3_9ANNE (tr|R7UHV3) Uncharacterized protein OS=Capitella te... 350 4e-94
R1GCB8_9PEZI (tr|R1GCB8) Putative methylenetetrahydrofolate redu... 350 5e-94
L7JK78_MAGOR (tr|L7JK78) Methylenetetrahydrofolate reductase OS=... 350 5e-94
L7IB80_MAGOR (tr|L7IB80) Methylenetetrahydrofolate reductase OS=... 350 5e-94
G4MV96_MAGO7 (tr|G4MV96) Methylenetetrahydrofolate reductase OS=... 350 5e-94
B8BRT9_THAPS (tr|B8BRT9) Methylenetetrahydrofolate reductase (Fr... 350 6e-94
G9P292_HYPAI (tr|G9P292) Methylenetetrahydrofolate reductase OS=... 350 6e-94
G2Q3E8_THIHA (tr|G2Q3E8) Methylenetetrahydrofolate reductase OS=... 350 6e-94
C5E412_ZYGRC (tr|C5E412) Methylenetetrahydrofolate reductase OS=... 349 1e-93
F7H2X2_CALJA (tr|F7H2X2) Methylenetetrahydrofolate reductase OS=... 349 1e-93
F7HIS1_CALJA (tr|F7HIS1) Methylenetetrahydrofolate reductase OS=... 349 1e-93
K1QN08_CRAGI (tr|K1QN08) Methylenetetrahydrofolate reductase OS=... 349 1e-93
F6SM95_CALJA (tr|F6SM95) Methylenetetrahydrofolate reductase OS=... 348 2e-93
Q5SNW6_HUMAN (tr|Q5SNW6) Methylenetetrahydrofolate reductase OS=... 348 2e-93
H0X153_OTOGA (tr|H0X153) Methylenetetrahydrofolate reductase OS=... 348 2e-93
G3RAX7_GORGO (tr|G3RAX7) Methylenetetrahydrofolate reductase OS=... 348 2e-93
H2PY11_PANTR (tr|H2PY11) Methylenetetrahydrofolate reductase OS=... 348 2e-93
G1SSR7_RABIT (tr|G1SSR7) Methylenetetrahydrofolate reductase OS=... 348 2e-93
K7DTF1_PANTR (tr|K7DTF1) Methylenetetrahydrofolate reductase OS=... 348 2e-93
K7C2K2_PANTR (tr|K7C2K2) Methylenetetrahydrofolate reductase OS=... 348 2e-93
C5M851_CANTT (tr|C5M851) Methylenetetrahydrofolate reductase OS=... 348 3e-93
M7UVH6_BOTFU (tr|M7UVH6) Putative methylenetetrahydrofolate redu... 348 3e-93
G2YUL6_BOTF4 (tr|G2YUL6) Methylenetetrahydrofolate reductase OS=... 348 3e-93
K1VJG4_TRIAC (tr|K1VJG4) Methylenetetrahydrofolate reductase OS=... 348 3e-93
J6F727_TRIAS (tr|J6F727) Methylenetetrahydrofolate reductase OS=... 348 3e-93
B2B2M5_PODAN (tr|B2B2M5) Methylenetetrahydrofolate reductase OS=... 348 3e-93
H2MXI6_ORYLA (tr|H2MXI6) Methylenetetrahydrofolate reductase OS=... 348 3e-93
M4AE75_XIPMA (tr|M4AE75) Methylenetetrahydrofolate reductase OS=... 347 4e-93
G0WG35_NAUDC (tr|G0WG35) Methylenetetrahydrofolate reductase OS=... 347 4e-93
A6RBU9_AJECN (tr|A6RBU9) Methylenetetrahydrofolate reductase OS=... 347 5e-93
J4TZ22_SACK1 (tr|J4TZ22) Methylenetetrahydrofolate reductase OS=... 347 7e-93
A7EWQ5_SCLS1 (tr|A7EWQ5) Methylenetetrahydrofolate reductase OS=... 347 7e-93
G7DSI2_MIXOS (tr|G7DSI2) Methylenetetrahydrofolate reductase OS=... 346 8e-93
B6QPH8_PENMQ (tr|B6QPH8) Methylenetetrahydrofolate reductase OS=... 346 1e-92
H0GUP5_9SACH (tr|H0GUP5) Methylenetetrahydrofolate reductase OS=... 346 1e-92
C3XPI2_BRAFL (tr|C3XPI2) Methylenetetrahydrofolate reductase OS=... 345 1e-92
L9L5F0_TUPCH (tr|L9L5F0) Methylenetetrahydrofolate reductase OS=... 345 1e-92
Q59GJ6_HUMAN (tr|Q59GJ6) Methylenetetrahydrofolate reductase (Fr... 345 2e-92
G8F4Z9_MACFA (tr|G8F4Z9) Methylenetetrahydrofolate reductase OS=... 345 2e-92
F7CI98_MACMU (tr|F7CI98) Methylenetetrahydrofolate reductase OS=... 345 2e-92
H9FUQ0_MACMU (tr|H9FUQ0) Methylenetetrahydrofolate reductase OS=... 345 2e-92
K5X1L7_AGABU (tr|K5X1L7) Methylenetetrahydrofolate reductase OS=... 345 2e-92
F7GJ76_MACMU (tr|F7GJ76) Methylenetetrahydrofolate reductase OS=... 345 2e-92
K9I4E4_AGABB (tr|K9I4E4) Methylenetetrahydrofolate reductase OS=... 345 2e-92
I3MA17_SPETR (tr|I3MA17) Methylenetetrahydrofolate reductase (Fr... 344 3e-92
B8M3Q9_TALSN (tr|B8M3Q9) Methylenetetrahydrofolate reductase OS=... 344 3e-92
F6RK00_CIOIN (tr|F6RK00) Methylenetetrahydrofolate reductase OS=... 344 4e-92
E4UPV6_ARTGP (tr|E4UPV6) Methylenetetrahydrofolate reductase OS=... 344 4e-92
L5KGS1_PTEAL (tr|L5KGS1) Methylenetetrahydrofolate reductase OS=... 344 5e-92
G0T0T7_RHOG2 (tr|G0T0T7) Methylenetetrahydrofolate reductase OS=... 343 6e-92
H3CC89_TETNG (tr|H3CC89) Methylenetetrahydrofolate reductase OS=... 343 6e-92
E4ZHE6_LEPMJ (tr|E4ZHE6) Methylenetetrahydrofolate reductase OS=... 343 7e-92
F6Z4F8_MOUSE (tr|F6Z4F8) Methylenetetrahydrofolate reductase (Fr... 342 1e-91
Q3UDB2_MOUSE (tr|Q3UDB2) Methylenetetrahydrofolate reductase OS=... 342 1e-91
A2A7F7_MOUSE (tr|A2A7F7) Methylenetetrahydrofolate reductase OS=... 342 1e-91
F1RF82_PIG (tr|F1RF82) Methylenetetrahydrofolate reductase OS=Su... 342 1e-91
Q4T956_TETNG (tr|Q4T956) Methylenetetrahydrofolate reductase OS=... 342 1e-91
K9IVF1_PIG (tr|K9IVF1) Methylenetetrahydrofolate reductase OS=Su... 342 1e-91
F9XCC6_MYCGM (tr|F9XCC6) Methylenetetrahydrofolate reductase OS=... 342 2e-91
G3IHM4_CRIGR (tr|G3IHM4) Methylenetetrahydrofolate reductase OS=... 341 3e-91
R0K2D2_SETTU (tr|R0K2D2) Uncharacterized protein OS=Setosphaeria... 341 3e-91
D2HKB9_AILME (tr|D2HKB9) Methylenetetrahydrofolate reductase (Fr... 341 3e-91
G1LTB1_AILME (tr|G1LTB1) Methylenetetrahydrofolate reductase OS=... 341 3e-91
M3YY87_MUSPF (tr|M3YY87) Methylenetetrahydrofolate reductase OS=... 341 3e-91
J7R7R4_KAZNA (tr|J7R7R4) Methylenetetrahydrofolate reductase OS=... 341 4e-91
Q7ZWU2_XENLA (tr|Q7ZWU2) Methylenetetrahydrofolate reductase OS=... 341 4e-91
F7CPK1_HORSE (tr|F7CPK1) Methylenetetrahydrofolate reductase OS=... 340 4e-91
C8Z8C5_YEAS8 (tr|C8Z8C5) Methylenetetrahydrofolate reductase OS=... 340 5e-91
G3PGI0_GASAC (tr|G3PGI0) Methylenetetrahydrofolate reductase OS=... 340 5e-91
E7LU98_YEASV (tr|E7LU98) Methylenetetrahydrofolate reductase OS=... 340 5e-91
E7KCE7_YEASA (tr|E7KCE7) Methylenetetrahydrofolate reductase OS=... 340 5e-91
B3LHI5_YEAS1 (tr|B3LHI5) Methylenetetrahydrofolate reductase OS=... 340 5e-91
G3PGH6_GASAC (tr|G3PGH6) Methylenetetrahydrofolate reductase (Fr... 340 5e-91
E7QEM0_YEASZ (tr|E7QEM0) Methylenetetrahydrofolate reductase OS=... 340 5e-91
N1P5B8_YEASX (tr|N1P5B8) Met13p OS=Saccharomyces cerevisiae CEN.... 340 5e-91
C7GX60_YEAS2 (tr|C7GX60) Methylenetetrahydrofolate reductase OS=... 340 5e-91
A6ZU57_YEAS7 (tr|A6ZU57) Methylenetetrahydrofolate reductase OS=... 340 5e-91
E7Q3R8_YEASB (tr|E7Q3R8) Methylenetetrahydrofolate reductase OS=... 340 7e-91
M2SQZ0_COCSA (tr|M2SQZ0) Methylenetetrahydrofolate reductase OS=... 340 8e-91
M3D6H6_9PEZI (tr|M3D6H6) Methylenetetrahydrofolate reductase OS=... 340 8e-91
L8IXC6_BOSMU (tr|L8IXC6) Methylenetetrahydrofolate reductase OS=... 340 9e-91
K9J856_XENTR (tr|K9J856) Methylenetetrahydrofolate reductase OS=... 339 1e-90
B2WMV1_PYRTR (tr|B2WMV1) Methylenetetrahydrofolate reductase OS=... 339 1e-90
N4WNX2_COCHE (tr|N4WNX2) Uncharacterized protein OS=Bipolaris ma... 339 1e-90
M2SSI3_COCHE (tr|M2SSI3) Methylenetetrahydrofolate reductase OS=... 339 1e-90
Q0U6C4_PHANO (tr|Q0U6C4) Methylenetetrahydrofolate reductase OS=... 339 1e-90
F1MF22_BOVIN (tr|F1MF22) Methylenetetrahydrofolate reductase OS=... 339 1e-90
F7AQ98_MONDO (tr|F7AQ98) Methylenetetrahydrofolate reductase OS=... 339 1e-90
G2WDX7_YEASK (tr|G2WDX7) Methylenetetrahydrofolate reductase OS=... 339 1e-90
F6V3H1_XENTR (tr|F6V3H1) Methylenetetrahydrofolate reductase OS=... 339 1e-90
A4IIX8_XENTR (tr|A4IIX8) Methylenetetrahydrofolate reductase OS=... 338 2e-90
E3RM42_PYRTT (tr|E3RM42) Methylenetetrahydrofolate reductase OS=... 338 2e-90
E6R5R3_CRYGW (tr|E6R5R3) Methylenetetrahydrofolate reductase OS=... 338 2e-90
D5GMM8_TUBMM (tr|D5GMM8) Methylenetetrahydrofolate reductase OS=... 338 2e-90
K7FMT0_PELSI (tr|K7FMT0) Methylenetetrahydrofolate reductase OS=... 338 3e-90
K7FMS5_PELSI (tr|K7FMS5) Methylenetetrahydrofolate reductase OS=... 337 3e-90
M3VU14_FELCA (tr|M3VU14) Methylenetetrahydrofolate reductase OS=... 337 4e-90
J9VRV0_CRYNH (tr|J9VRV0) Methylenetetrahydrofolate reductase OS=... 337 4e-90
M7BWD2_CHEMY (tr|M7BWD2) Methylenetetrahydrofolate reductase OS=... 337 4e-90
H0GFV1_9SACH (tr|H0GFV1) Methylenetetrahydrofolate reductase OS=... 337 5e-90
E7NHJ8_YEASO (tr|E7NHJ8) Methylenetetrahydrofolate reductase OS=... 337 5e-90
I3KND8_ORENI (tr|I3KND8) Methylenetetrahydrofolate reductase OS=... 337 6e-90
R0JRL3_ANAPL (tr|R0JRL3) Methylenetetrahydrofolate reductase (Fr... 337 7e-90
J4UUR5_BEAB2 (tr|J4UUR5) Methylenetetrahydrofolate reductase OS=... 336 8e-90
E1BXL1_CHICK (tr|E1BXL1) Methylenetetrahydrofolate reductase OS=... 335 1e-89
E9HJT0_DAPPU (tr|E9HJT0) Methylenetetrahydrofolate reductase OS=... 335 2e-89
B7G287_PHATC (tr|B7G287) Methylenetetrahydrofolate reductase OS=... 335 2e-89
J3S088_CROAD (tr|J3S088) Methylenetetrahydrofolate reductase OS=... 335 2e-89
G1N3J8_MELGA (tr|G1N3J8) Methylenetetrahydrofolate reductase (Fr... 335 3e-89
Q5K8Q9_CRYNJ (tr|Q5K8Q9) Methylenetetrahydrofolate reductase OS=... 334 3e-89
F5HGC8_CRYNB (tr|F5HGC8) Methylenetetrahydrofolate reductase OS=... 334 3e-89
E2QXW9_CANFA (tr|E2QXW9) Methylenetetrahydrofolate reductase OS=... 334 4e-89
G0VEA4_NAUCC (tr|G0VEA4) Methylenetetrahydrofolate reductase OS=... 334 4e-89
G8JR06_ERECY (tr|G8JR06) Methylenetetrahydrofolate reductase OS=... 333 5e-89
H3AKG0_LATCH (tr|H3AKG0) Methylenetetrahydrofolate reductase OS=... 333 6e-89
G3T6N6_LOXAF (tr|G3T6N6) Methylenetetrahydrofolate reductase OS=... 333 6e-89
M7WNN9_RHOTO (tr|M7WNN9) Methylenetetrahydrofolate reductase (NA... 333 7e-89
G3JDV9_CORMM (tr|G3JDV9) Methylenetetrahydrofolate reductase OS=... 333 8e-89
N1PKU2_MYCPJ (tr|N1PKU2) Uncharacterized protein OS=Dothistroma ... 333 9e-89
F0XGD2_GROCL (tr|F0XGD2) Methylenetetrahydrofolate reductase OS=... 332 1e-88
D4A7E8_RAT (tr|D4A7E8) Methylenetetrahydrofolate reductase OS=Ra... 332 2e-88
G3AY82_CANTC (tr|G3AY82) Methylenetetrahydrofolate reductase OS=... 331 3e-88
G8ZXU8_TORDC (tr|G8ZXU8) Methylenetetrahydrofolate reductase OS=... 331 3e-88
M3ARN4_9PEZI (tr|M3ARN4) Methylenetetrahydrofolate reductase OS=... 330 5e-88
K0TBA8_THAOC (tr|K0TBA8) Methylenetetrahydrofolate reductase OS=... 330 6e-88
H0YVV8_TAEGU (tr|H0YVV8) Methylenetetrahydrofolate reductase OS=... 330 6e-88
C5K575_PERM5 (tr|C5K575) Methylenetetrahydrofolate reductase OS=... 330 7e-88
H0UZL8_CAVPO (tr|H0UZL8) Methylenetetrahydrofolate reductase (Fr... 330 7e-88
M3ILJ3_CANMA (tr|M3ILJ3) Methylenetetrahydrofolate reductase OS=... 330 7e-88
H0EVR8_GLAL7 (tr|H0EVR8) Methylenetetrahydrofolate reductase OS=... 330 7e-88
N4UDI4_FUSOX (tr|N4UDI4) Methylenetetrahydrofolate reductase 1 O... 330 8e-88
G4UIN5_NEUT9 (tr|G4UIN5) Methylenetetrahydrofolate reductase OS=... 329 9e-88
F8MJ09_NEUT8 (tr|F8MJ09) Methylenetetrahydrofolate reductase OS=... 329 9e-88
Q7S830_NEUCR (tr|Q7S830) Methylenetetrahydrofolate reductase OS=... 329 1e-87
M2N3N4_9PEZI (tr|M2N3N4) Methylenetetrahydrofolate reductase OS=... 329 1e-87
G1PJ01_MYOLU (tr|G1PJ01) Methylenetetrahydrofolate reductase OS=... 329 1e-87
B9WDQ7_CANDC (tr|B9WDQ7) Methylenetetrahydrofolate reductase OS=... 328 2e-87
L8G9A3_GEOD2 (tr|L8G9A3) Methylenetetrahydrofolate reductase OS=... 328 3e-87
G3AQG4_SPAPN (tr|G3AQG4) Methylenetetrahydrofolate reductase OS=... 328 3e-87
C4Y415_CLAL4 (tr|C4Y415) Methylenetetrahydrofolate reductase OS=... 328 3e-87
G5C506_HETGA (tr|G5C506) Methylenetetrahydrofolate reductase OS=... 328 3e-87
Q5AEI0_CANAL (tr|Q5AEI0) Methylenetetrahydrofolate reductase OS=... 327 5e-87
C4YQ60_CANAW (tr|C4YQ60) Methylenetetrahydrofolate reductase OS=... 327 5e-87
F6TEC5_ORNAN (tr|F6TEC5) Methylenetetrahydrofolate reductase OS=... 326 9e-87
A3LUC7_PICST (tr|A3LUC7) Methylenetetrahydrofolate reductase OS=... 326 1e-86
R8BDU8_9PEZI (tr|R8BDU8) Putative methylenetetrahydrofolate redu... 325 2e-86
F1KZ16_ASCSU (tr|F1KZ16) Methylenetetrahydrofolate reductase OS=... 325 3e-86
F7VNA4_SORMK (tr|F7VNA4) Methylenetetrahydrofolate reductase OS=... 324 3e-86
A7S360_NEMVE (tr|A7S360) Methylenetetrahydrofolate reductase OS=... 324 4e-86
A5DXM5_LODEL (tr|A5DXM5) Methylenetetrahydrofolate reductase OS=... 323 5e-86
B5RV11_DEBHA (tr|B5RV11) Methylenetetrahydrofolate reductase OS=... 323 7e-86
G8BYR2_TETPH (tr|G8BYR2) Methylenetetrahydrofolate reductase OS=... 323 8e-86
M4BSS5_HYAAE (tr|M4BSS5) Methylenetetrahydrofolate reductase OS=... 322 1e-85
I1FJF2_AMPQE (tr|I1FJF2) Methylenetetrahydrofolate reductase OS=... 322 1e-85
M4FNZ6_MAGP6 (tr|M4FNZ6) Methylenetetrahydrofolate reductase OS=... 322 1e-85
G8B6Z3_CANPC (tr|G8B6Z3) Methylenetetrahydrofolate reductase OS=... 321 4e-85
L2FEI5_COLGN (tr|L2FEI5) Methylenetetrahydrofolate reductase OS=... 320 4e-85
J3NNB0_GAGT3 (tr|J3NNB0) Methylenetetrahydrofolate reductase OS=... 320 5e-85
K3WFD4_PYTUL (tr|K3WFD4) Methylenetetrahydrofolate reductase OS=... 320 6e-85
C5L500_PERM5 (tr|C5L500) Methylenetetrahydrofolate reductase OS=... 319 1e-84
H8X156_CANO9 (tr|H8X156) Methylenetetrahydrofolate reductase OS=... 319 1e-84
Q6CKM1_KLULA (tr|Q6CKM1) Methylenetetrahydrofolate reductase OS=... 318 2e-84
B6K4Z7_SCHJY (tr|B6K4Z7) Methylenetetrahydrofolate reductase OS=... 318 2e-84
F2QR20_PICP7 (tr|F2QR20) Methylenetetrahydrofolate reductase OS=... 316 1e-83
G8YAU9_PICSO (tr|G8YAU9) Methylenetetrahydrofolate reductase OS=... 314 3e-83
I2H5Z0_TETBL (tr|I2H5Z0) Methylenetetrahydrofolate reductase OS=... 314 5e-83
D8LCN9_ECTSI (tr|D8LCN9) Methylenetetrahydrofolate reductase OS=... 310 7e-82
K2QJU3_MACPH (tr|K2QJU3) Methylenetetrahydrofolate reductase OS=... 310 9e-82
B8BVS6_THAPS (tr|B8BVS6) Methylenetetrahydrofolate reductase OS=... 308 2e-81
E3KZT2_PUCGT (tr|E3KZT2) Methylenetetrahydrofolate reductase OS=... 307 5e-81
E9CGW7_CAPO3 (tr|E9CGW7) Methylenetetrahydrofolate reductase OS=... 305 3e-80
H3G9J6_PHYRM (tr|H3G9J6) Methylenetetrahydrofolate reductase OS=... 302 2e-79
G4ZJB0_PHYSP (tr|G4ZJB0) Methylenetetrahydrofolate reductase OS=... 300 5e-79
F0WFI8_9STRA (tr|F0WFI8) Methylenetetrahydrofolate reductase OS=... 300 9e-79
A8PV87_BRUMA (tr|A8PV87) Methylenetetrahydrofolate reductase OS=... 298 3e-78
I1CGQ8_RHIO9 (tr|I1CGQ8) Methylenetetrahydrofolate reductase OS=... 298 3e-78
E1G613_LOALO (tr|E1G613) Methylenetetrahydrofolate reductase OS=... 297 4e-78
K0TG67_THAOC (tr|K0TG67) Methylenetetrahydrofolate reductase OS=... 296 7e-78
G8JXY2_CAEEL (tr|G8JXY2) Methylenetetrahydrofolate reductase OS=... 296 9e-78
K7HSL3_CAEJA (tr|K7HSL3) Methylenetetrahydrofolate reductase OS=... 296 1e-77
M4BR52_HYAAE (tr|M4BR52) Methylenetetrahydrofolate reductase OS=... 296 1e-77
H2W4Y4_CAEJA (tr|H2W4Y4) Methylenetetrahydrofolate reductase (Fr... 295 2e-77
D8LT26_ECTSI (tr|D8LT26) Methylenetetrahydrofolate reductase OS=... 292 1e-76
G7E669_MIXOS (tr|G7E669) Methylenetetrahydrofolate reductase OS=... 291 2e-76
C4R2Q6_PICPG (tr|C4R2Q6) Methylenetetrahydrofolate reductase OS=... 290 6e-76
A8XGR9_CAEBR (tr|A8XGR9) Methylenetetrahydrofolate reductase OS=... 290 6e-76
A9UZU5_MONBE (tr|A9UZU5) Methylenetetrahydrofolate reductase OS=... 290 6e-76
F0XZS1_AURAN (tr|F0XZS1) Methylenetetrahydrofolate reductase OS=... 290 7e-76
E3MN18_CAERE (tr|E3MN18) Methylenetetrahydrofolate reductase OS=... 290 7e-76
E9CFC5_CAPO3 (tr|E9CFC5) Methylenetetrahydrofolate reductase OS=... 288 3e-75
G4TRD0_PIRID (tr|G4TRD0) Methylenetetrahydrofolate reductase OS=... 283 9e-74
M9LZ85_9BASI (tr|M9LZ85) 5,10-methylenetetrahydrofolate reductas... 279 2e-72
R1BLH4_EMIHU (tr|R1BLH4) Putative methylenetetrahydrofolate redu... 278 2e-72
A4HQF9_LEIBR (tr|A4HQF9) Methylenetetrahydrofolate reductase OS=... 277 4e-72
A7TTE9_VANPO (tr|A7TTE9) Methylenetetrahydrofolate reductase OS=... 277 4e-72
M5BQ62_9HOMO (tr|M5BQ62) Uncharacterized protein OS=Rhizoctonia ... 277 5e-72
B7GB47_PHATC (tr|B7GB47) Methylenetetrahydrofolate reductase (Fr... 276 2e-71
H3F1N6_PRIPA (tr|H3F1N6) Methylenetetrahydrofolate reductase OS=... 273 8e-71
M3ZAC4_NOMLE (tr|M3ZAC4) Methylenetetrahydrofolate reductase OS=... 273 1e-70
I3SJD2_MEDTR (tr|I3SJD2) Methylenetetrahydrofolate reductase OS=... 271 3e-70
E9AU75_LEIMU (tr|E9AU75) Methylenetetrahydrofolate reductase OS=... 268 3e-69
F8Q7Q5_SERL3 (tr|F8Q7Q5) Methylenetetrahydrofolate reductase OS=... 268 4e-69
F8P6Q6_SERL9 (tr|F8P6Q6) Methylenetetrahydrofolate reductase OS=... 268 4e-69
G9KBN9_MUSPF (tr|G9KBN9) Methylenetetrahydrofolate reductase (Fr... 267 5e-69
B0CSW4_LACBS (tr|B0CSW4) Methylenetetrahydrofolate reductase OS=... 267 6e-69
J3QDS4_PUCT1 (tr|J3QDS4) Methylenetetrahydrofolate reductase OS=... 267 6e-69
K1WUF3_TRIAC (tr|K1WUF3) Methylenetetrahydrofolate reductase OS=... 266 1e-68
J6EUJ9_TRIAS (tr|J6EUJ9) Methylenetetrahydrofolate reductase OS=... 266 1e-68
E9BV23_LEIDB (tr|E9BV23) Methylenetetrahydrofolate reductase OS=... 263 8e-68
A4IC95_LEIIN (tr|A4IC95) Methylenetetrahydrofolate reductase OS=... 263 8e-68
A8Q9P3_MALGO (tr|A8Q9P3) Methylenetetrahydrofolate reductase OS=... 263 1e-67
M5E942_MALSM (tr|M5E942) Genomic scaffold, msy_sf_9 OS=Malassezi... 261 3e-67
Q4Q0B9_LEIMA (tr|Q4Q0B9) Methylenetetrahydrofolate reductase OS=... 260 6e-67
E6QYL4_CRYGW (tr|E6QYL4) Methylenetetrahydrofolate reductase OS=... 260 6e-67
K5W8I5_PHACS (tr|K5W8I5) Methylenetetrahydrofolate reductase OS=... 260 6e-67
A3LW82_PICST (tr|A3LW82) Methylenetetrahydrofolate reductase OS=... 260 8e-67
Q4P1E8_USTMA (tr|Q4P1E8) Methylenetetrahydrofolate reductase OS=... 258 3e-66
M2QM94_CERSU (tr|M2QM94) Methylenetetrahydrofolate reductase OS=... 258 4e-66
G8BIZ7_CANPC (tr|G8BIZ7) Methylenetetrahydrofolate reductase OS=... 257 5e-66
E6ZVM6_SPORE (tr|E6ZVM6) Methylenetetrahydrofolate reductase OS=... 257 5e-66
M7WXP1_RHOTO (tr|M7WXP1) Methylenetetrahydrofolate reductase (NA... 257 6e-66
H8X3U3_CANO9 (tr|H8X3U3) Methylenetetrahydrofolate reductase OS=... 257 6e-66
Q5KN82_CRYNJ (tr|Q5KN82) Methylenetetrahydrofolate reductase OS=... 256 8e-66
F5HHA5_CRYNB (tr|F5HHA5) Methylenetetrahydrofolate reductase OS=... 256 8e-66
M3K3T4_CANMA (tr|M3K3T4) Methylenetetrahydrofolate reductase OS=... 256 1e-65
M5GA04_DACSP (tr|M5GA04) MTHFR-domain-containing protein OS=Dacr... 256 1e-65
J9VMK3_CRYNH (tr|J9VMK3) Methylenetetrahydrofolate reductase OS=... 256 2e-65
G3AM20_SPAPN (tr|G3AM20) Methylenetetrahydrofolate reductase OS=... 255 2e-65
R9NZU2_9BASI (tr|R9NZU2) Methylenetetrahydrofolate reductase OS=... 255 2e-65
A5DE00_PICGU (tr|A5DE00) Methylenetetrahydrofolate reductase OS=... 255 2e-65
C4Y9Q4_CLAL4 (tr|C4Y9Q4) Methylenetetrahydrofolate reductase OS=... 254 4e-65
K5XGF3_AGABU (tr|K5XGF3) Methylenetetrahydrofolate reductase OS=... 254 5e-65
Q5A5S8_CANAL (tr|Q5A5S8) Methylenetetrahydrofolate reductase OS=... 254 5e-65
F2QR60_PICP7 (tr|F2QR60) Methylenetetrahydrofolate reductase OS=... 253 7e-65
C4R2L4_PICPG (tr|C4R2L4) Methylenetetrahydrofolate reductase OS=... 253 7e-65
C4YKV3_CANAW (tr|C4YKV3) Methylenetetrahydrofolate reductase OS=... 253 1e-64
Q6BM19_DEBHA (tr|Q6BM19) Methylenetetrahydrofolate reductase OS=... 251 4e-64
H0ZU30_TAEGU (tr|H0ZU30) Methylenetetrahydrofolate reductase OS=... 251 4e-64
A5DZ35_LODEL (tr|A5DZ35) Methylenetetrahydrofolate reductase OS=... 251 5e-64
K9I5Z0_AGABB (tr|K9I5Z0) Methylenetetrahydrofolate reductase OS=... 250 6e-64
R4XEG2_9ASCO (tr|R4XEG2) Uncharacterized protein OS=Taphrina def... 250 8e-64
Q6CEM7_YARLI (tr|Q6CEM7) Methylenetetrahydrofolate reductase OS=... 249 1e-63
F4S8A9_MELLP (tr|F4S8A9) Methylenetetrahydrofolate reductase OS=... 249 1e-63
G3B7S7_CANTC (tr|G3B7S7) Methylenetetrahydrofolate reductase OS=... 248 3e-63
B9WCV3_CANDC (tr|B9WCV3) Methylenetetrahydrofolate reductase OS=... 248 3e-63
C5DPF1_ZYGRC (tr|C5DPF1) Methylenetetrahydrofolate reductase OS=... 247 8e-63
D8PVA5_SCHCM (tr|D8PVA5) Methylenetetrahydrofolate reductase OS=... 246 8e-63
E5SN41_TRISP (tr|E5SN41) Methylenetetrahydrofolate reductase OS=... 246 1e-62
C5FI42_ARTOC (tr|C5FI42) Methylenetetrahydrofolate reductase OS=... 245 2e-62
C5M548_CANTT (tr|C5M548) Methylenetetrahydrofolate reductase OS=... 244 3e-62
J4H1L8_FIBRA (tr|J4H1L8) Methylenetetrahydrofolate reductase OS=... 242 2e-61
I2FQ18_USTH4 (tr|I2FQ18) Methylenetetrahydrofolate reductase OS=... 241 4e-61
G8YA65_PICSO (tr|G8YA65) Methylenetetrahydrofolate reductase OS=... 241 5e-61
Q752W6_ASHGO (tr|Q752W6) Methylenetetrahydrofolate reductase OS=... 241 5e-61
F2UPH6_SALS5 (tr|F2UPH6) Methylenetetrahydrofolate reductase OS=... 240 8e-61
M9N544_ASHGS (tr|M9N544) FAFR457Wp OS=Ashbya gossypii FDAG1 GN=F... 239 1e-60
H1VQF9_COLHI (tr|H1VQF9) Methylenetetrahydrofolate reductase OS=... 239 1e-60
A1C4Z1_ASPCL (tr|A1C4Z1) Methylenetetrahydrofolate reductase OS=... 238 4e-60
N4W0R1_COLOR (tr|N4W0R1) Methylenetetrahydrofolate reductase OS=... 238 4e-60
R1GLW2_9PEZI (tr|R1GLW2) Putative methylenetetrahydrofolate redu... 238 4e-60
B8NQE8_ASPFN (tr|B8NQE8) Methylenetetrahydrofolate reductase OS=... 238 5e-60
K0KI23_WICCF (tr|K0KI23) Methylenetetrahydrofolate reductase OS=... 237 5e-60
Q2UA39_ASPOR (tr|Q2UA39) Methylenetetrahydrofolate reductase OS=... 236 8e-60
I8A5G3_ASPO3 (tr|I8A5G3) Methylenetetrahydrofolate reductase OS=... 236 8e-60
Q60CG9_METCA (tr|Q60CG9) Methylenetetrahydrofolate reductase OS=... 236 1e-59
D5G9J4_TUBMM (tr|D5G9J4) Methylenetetrahydrofolate reductase OS=... 236 1e-59
H0EJ23_GLAL7 (tr|H0EJ23) Methylenetetrahydrofolate reductase OS=... 235 2e-59
G7XN52_ASPKW (tr|G7XN52) Methylenetetrahydrofolate reductase OS=... 235 3e-59
A7TRT4_VANPO (tr|A7TRT4) Methylenetetrahydrofolate reductase OS=... 234 4e-59
Q6FNS2_CANGA (tr|Q6FNS2) Methylenetetrahydrofolate reductase OS=... 234 6e-59
B4D0K5_9BACT (tr|B4D0K5) Methylenetetrahydrofolate reductase OS=... 234 6e-59
E3QAK3_COLGM (tr|E3QAK3) Methylenetetrahydrofolate reductase OS=... 233 9e-59
G3XLM4_ASPNA (tr|G3XLM4) Methylenetetrahydrofolate reductase OS=... 233 9e-59
H2N935_PONAB (tr|H2N935) Methylenetetrahydrofolate reductase (Fr... 233 1e-58
G8ZNU7_TORDC (tr|G8ZNU7) Methylenetetrahydrofolate reductase OS=... 233 1e-58
A1CZX0_NEOFI (tr|A1CZX0) Methylenetetrahydrofolate reductase OS=... 233 1e-58
G8BRG4_TETPH (tr|G8BRG4) Methylenetetrahydrofolate reductase OS=... 232 3e-58
Q0CE17_ASPTN (tr|Q0CE17) Methylenetetrahydrofolate reductase OS=... 231 3e-58
K1WXP9_MARBU (tr|K1WXP9) Methylenetetrahydrofolate reductase OS=... 231 6e-58
A2QUJ5_ASPNC (tr|A2QUJ5) Methylenetetrahydrofolate reductase OS=... 231 6e-58
H6BSG9_EXODN (tr|H6BSG9) Methylenetetrahydrofolate reductase OS=... 230 7e-58
K2S237_MACPH (tr|K2S237) Methylenetetrahydrofolate reductase OS=... 230 8e-58
B0Y2U3_ASPFC (tr|B0Y2U3) Methylenetetrahydrofolate reductase OS=... 230 8e-58
Q4WEL9_ASPFU (tr|Q4WEL9) Methylenetetrahydrofolate reductase OS=... 230 9e-58
G0RUZ1_HYPJQ (tr|G0RUZ1) Methylenetetrahydrofolate reductase OS=... 230 9e-58
L7U9T6_MYXSD (tr|L7U9T6) Methylenetetrahydrofolate reductase OS=... 229 1e-57
G9NF79_HYPAI (tr|G9NF79) Methylenetetrahydrofolate reductase OS=... 229 1e-57
E4URV2_ARTGP (tr|E4URV2) Methylenetetrahydrofolate reductase OS=... 229 2e-57
F2SNP6_TRIRC (tr|F2SNP6) Methylenetetrahydrofolate reductase OS=... 229 2e-57
A8QAM7_MALGO (tr|A8QAM7) Methylenetetrahydrofolate reductase OS=... 228 3e-57
Q5AU15_EMENI (tr|Q5AU15) Methylenetetrahydrofolate reductase OS=... 228 3e-57
Q0GA68_EMEND (tr|Q0GA68) Methylenetetrahydrofolate reductase OS=... 228 3e-57
D3FCP0_CONWI (tr|D3FCP0) Methylenetetrahydrofolate reductase OS=... 228 4e-57
B6QFH8_PENMQ (tr|B6QFH8) Methylenetetrahydrofolate reductase OS=... 228 4e-57
E9DS87_METAQ (tr|E9DS87) Methylenetetrahydrofolate reductase OS=... 228 5e-57
Q7S2B6_NEUCR (tr|Q7S2B6) Methylenetetrahydrofolate reductase OS=... 228 5e-57
Q6MVY6_NEUCS (tr|Q6MVY6) Methylenetetrahydrofolate reductase OS=... 228 5e-57
L7J0Y9_MAGOR (tr|L7J0Y9) Methylenetetrahydrofolate reductase OS=... 227 5e-57
L7IP25_MAGOR (tr|L7IP25) Methylenetetrahydrofolate reductase OS=... 227 5e-57
G4MZ63_MAGO7 (tr|G4MZ63) Methylenetetrahydrofolate reductase OS=... 227 5e-57
D4AR17_ARTBC (tr|D4AR17) Methylenetetrahydrofolate reductase OS=... 227 6e-57
R8BQ93_9PEZI (tr|R8BQ93) Putative methylenetetrahydrofolate redu... 227 7e-57
D4DDN3_TRIVH (tr|D4DDN3) Methylenetetrahydrofolate reductase OS=... 227 7e-57
I4YDE9_WALSC (tr|I4YDE9) Methylenetetrahydrofolate reductase OS=... 227 8e-57
B4UHX4_ANASK (tr|B4UHX4) Methylenetetrahydrofolate reductase OS=... 227 8e-57
G9MEA0_HYPVG (tr|G9MEA0) Methylenetetrahydrofolate reductase OS=... 227 8e-57
L8GA37_GEOD2 (tr|L8GA37) Methylenetetrahydrofolate reductase OS=... 226 1e-56
G4UHF1_NEUT9 (tr|G4UHF1) Methylenetetrahydrofolate reductase OS=... 226 1e-56
F8MCY9_NEUT8 (tr|F8MCY9) Methylenetetrahydrofolate reductase OS=... 226 1e-56
Q08QG9_STIAD (tr|Q08QG9) Methylenetetrahydrofolate reductase OS=... 226 1e-56
D7BAR9_MEISD (tr|D7BAR9) Methylenetetrahydrofolate reductase OS=... 226 1e-56
E3FGW3_STIAD (tr|E3FGW3) Methylenetetrahydrofolate reductase OS=... 226 2e-56
J3NGV8_GAGT3 (tr|J3NGV8) Methylenetetrahydrofolate reductase OS=... 225 2e-56
E6UMU2_CLOTL (tr|E6UMU2) Methylenetetrahydrofolate reductase OS=... 225 2e-56
A3DBL1_CLOTH (tr|A3DBL1) Methylenetetrahydrofolate reductase OS=... 225 2e-56
D1NKV9_CLOTM (tr|D1NKV9) Methylenetetrahydrofolate reductase OS=... 225 2e-56
C7HFT8_CLOTM (tr|C7HFT8) Methylenetetrahydrofolate reductase OS=... 225 2e-56
M4G477_MAGP6 (tr|M4G477) Methylenetetrahydrofolate reductase OS=... 225 2e-56
A7E9M9_SCLS1 (tr|A7E9M9) Methylenetetrahydrofolate reductase OS=... 225 2e-56
G0PNQ6_CAEBE (tr|G0PNQ6) Methylenetetrahydrofolate reductase (Fr... 225 3e-56
F2PS11_TRIEC (tr|F2PS11) Methylenetetrahydrofolate reductase OS=... 224 4e-56
B8JEQ3_ANAD2 (tr|B8JEQ3) Methylenetetrahydrofolate reductase OS=... 224 4e-56
E9F4X1_METAR (tr|E9F4X1) Methylenetetrahydrofolate reductase OS=... 224 5e-56
>I1JZE1_SOYBN (tr|I1JZE1) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 596
Score = 766 bits (1977), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 363/411 (88%), Positives = 384/411 (93%), Gaps = 3/411 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+R DP+RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGG+
Sbjct: 1 MKIIEKIRAASA-DPNRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGT 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIANKMQNIVCVETM+HLTCTNMPVEKID+AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLV+HIRAKYGDYFGIT+AGYPEAHPD I SDG+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITIAGYPEAHPDVIESDGLATPEGYRNDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESK+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS
Sbjct: 300 NLGLIEESKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSC 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
NPSYGAL+DYQFMRPRARDKKL EEWAVPL+S+EDIY V + YC L
Sbjct: 360 NPSYGALSDYQFMRPRARDKKLVEEWAVPLKSVEDIYEV--RFRLYCLGKL 408
>I1JZE2_SOYBN (tr|I1JZE2) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 595
Score = 765 bits (1975), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 361/403 (89%), Positives = 381/403 (94%), Gaps = 1/403 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+R DP+RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGG+
Sbjct: 1 MKIIEKIRAASA-DPNRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGT 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIANKMQNIVCVETM+HLTCTNMPVEKID+AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLV+HIRAKYGDYFGIT+AGYPEAHPD I SDG+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITIAGYPEAHPDVIESDGLATPEGYRNDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESK+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS
Sbjct: 300 NLGLIEESKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSC 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLY 403
NPSYGAL+DYQFMRPRARDKKL EEWAVPL+S+EDIY LY
Sbjct: 360 NPSYGALSDYQFMRPRARDKKLVEEWAVPLKSVEDIYERFRLY 402
>I1KG04_SOYBN (tr|I1KG04) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 571
Score = 762 bits (1968), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 360/403 (89%), Positives = 379/403 (94%), Gaps = 1/403 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+ DP+RVVFSFEFFPPKTEDGVDNLFERMDRMV HNPSFCDITWGAGG+
Sbjct: 1 MKIIEKIHAASA-DPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWGAGGT 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIANKMQNIVCVETM+HLTCTNMPVEKID+AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLV+HIRAKYGDYFGITVAGYPEAHPD I SDG+AT+E YQN+L Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGI TLHLYTLNMEKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEE+K+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS
Sbjct: 300 NLGLIEETKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSC 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLY 403
NPSYGAL+DYQFMRPRARDKKL EEWAVPL+SIEDIY LY
Sbjct: 360 NPSYGALSDYQFMRPRARDKKLVEEWAVPLKSIEDIYERFRLY 402
>I1KG02_SOYBN (tr|I1KG02) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 595
Score = 762 bits (1968), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 360/403 (89%), Positives = 379/403 (94%), Gaps = 1/403 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+ DP+RVVFSFEFFPPKTEDGVDNLFERMDRMV HNPSFCDITWGAGG+
Sbjct: 1 MKIIEKIHAASA-DPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWGAGGT 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIANKMQNIVCVETM+HLTCTNMPVEKID+AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLV+HIRAKYGDYFGITVAGYPEAHPD I SDG+AT+E YQN+L Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGI TLHLYTLNMEKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEE+K+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS
Sbjct: 300 NLGLIEETKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSC 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLY 403
NPSYGAL+DYQFMRPRARDKKL EEWAVPL+SIEDIY LY
Sbjct: 360 NPSYGALSDYQFMRPRARDKKLVEEWAVPLKSIEDIYERFRLY 402
>I1KG03_SOYBN (tr|I1KG03) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 462
Score = 762 bits (1967), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 360/403 (89%), Positives = 379/403 (94%), Gaps = 1/403 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+ DP+RVVFSFEFFPPKTEDGVDNLFERMDRMV HNPSFCDITWGAGG+
Sbjct: 1 MKIIEKIHAASA-DPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWGAGGT 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIANKMQNIVCVETM+HLTCTNMPVEKID+AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLV+HIRAKYGDYFGITVAGYPEAHPD I SDG+AT+E YQN+L Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGI TLHLYTLNMEKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEE+K+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS
Sbjct: 300 NLGLIEETKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSC 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLY 403
NPSYGAL+DYQFMRPRARDKKL EEWAVPL+SIEDIY LY
Sbjct: 360 NPSYGALSDYQFMRPRARDKKLVEEWAVPLKSIEDIYERFRLY 402
>B9HG95_POPTR (tr|B9HG95) Methylenetetrahydrofolate reductase OS=Populus
trichocarpa GN=MTHFR1 PE=3 SV=1
Length = 608
Score = 734 bits (1896), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 346/409 (84%), Positives = 372/409 (90%), Gaps = 12/409 (2%)
Query: 1 MKVIEKVRXXXX------------XDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNP 48
MKVI+K+R ++VVFSFEFFPPKTEDGVDNLFERMDRMVAHNP
Sbjct: 1 MKVIDKIREAAGGGGDANGNGGDNSSSNKVVFSFEFFPPKTEDGVDNLFERMDRMVAHNP 60
Query: 49 SFCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQN 108
SFCDITWGAGGSTAD+TL+IANKMQNI+CVETM+HLTCTNMPVEKID+AL+TIKSNG+QN
Sbjct: 61 SFCDITWGAGGSTADLTLDIANKMQNIICVETMMHLTCTNMPVEKIDHALETIKSNGIQN 120
Query: 109 VLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGV 168
VLALRGDPPHGQDKFVQ +GGFACA DLVKHIR+KYGDYFGITVAGYPEAHPDAIGSDG
Sbjct: 121 VLALRGDPPHGQDKFVQIQGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDAIGSDGF 180
Query: 169 ATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINN 228
AT E YQ +L YLK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINN
Sbjct: 181 ATPEDYQKDLAYLKQKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINN 240
Query: 229 YKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYT 288
YKGF+RMTGFCKTKIPAE+ AALEPIKDNEEAV+ YGIHLGTEMC+KILAHGIKTLHLYT
Sbjct: 241 YKGFLRMTGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYT 300
Query: 289 LNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW 348
LNMEKSALAIL +LGLIEESKI+R+LPWR PTNVFR +EDVRPIFWANRPKSY+SRTIGW
Sbjct: 301 LNMEKSALAILMNLGLIEESKITRALPWRPPTNVFRAKEDVRPIFWANRPKSYLSRTIGW 360
Query: 349 DQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
DQYPHGRWGDS NPSYGAL+DYQFMRPRAR KKL EEWA PL+S+EDIY
Sbjct: 361 DQYPHGRWGDSHNPSYGALSDYQFMRPRARGKKLFEEWASPLKSVEDIY 409
>M5W952_PRUPE (tr|M5W952) Uncharacterized protein OS=Prunus persica
GN=PRUPE_ppa003184mg PE=4 SV=1
Length = 595
Score = 732 bits (1889), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/397 (85%), Positives = 373/397 (93%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ + +V+FSFEFFPPKTEDGV+NL ERM+RMVAHNP+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEALLEE-KKVLFSFEFFPPKTEDGVENLLERMERMVAHNPAFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IANKMQNI+CVE+M+HLTCTNMPV+KID+ALQTIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLDIANKMQNIICVESMMHLTCTNMPVDKIDHALQTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ +GGFACA DLV HIRAKYGDYFG+TVAGYPEAHPDAIG+DG+A+ EAYQ++L Y
Sbjct: 120 DKFVQIQGGFACALDLVTHIRAKYGDYFGVTVAGYPEAHPDAIGTDGLASPEAYQSDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD+FLKFV+DC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKRKVDAGADLIITQLFYDTDVFLKFVHDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+ AALEPIKDNEEAVK YGIHLGTEMC+KILAHGI+TLHLYTLNMEKSALAIL
Sbjct: 240 TKIPAEVTAALEPIKDNEEAVKSYGIHLGTEMCKKILAHGIRTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEE+KISR LPWRRP NVFRV+EDVRPIFWANRPKSYISRTIGWD YPHGRWGDS
Sbjct: 300 NLGLIEETKISRPLPWRRPANVFRVKEDVRPIFWANRPKSYISRTIGWDLYPHGRWGDSR 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMRPRARDKKL EEW VPLRS+EDI+
Sbjct: 360 NPSYGALTDYQFMRPRARDKKLVEEWVVPLRSVEDIH 396
>M1C551_SOLTU (tr|M1C551) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400023361 PE=3 SV=1
Length = 460
Score = 725 bits (1872), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/411 (82%), Positives = 374/411 (90%), Gaps = 5/411 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D RVVFSFEFFPPKTEDGVDNLFERM+RMV+HNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+N+MQN+VCVETM+HLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKH+RAKYGDYFGITVAGYPEAHPD I + G+AT E Y+NEL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPATGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTD FLKFV+DC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIVTQLFYDTDNFLKFVSDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T+IPAEI AALEPIKDNEEAVK YGIHLGTEMC+KI+A GIKTLHLYTLNMEKSALAIL
Sbjct: 239 TRIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFR++EDVRPIFWANRPKSYISRTIGWD++PHGRWG++
Sbjct: 299 NLGLIEESKISRPLPWRRPTNVFRIKEDVRPIFWANRPKSYISRTIGWDEFPHGRWGNAK 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
NPSYGAL+DYQFMR R+RDKKL EEWA+ L S+EDIY ++ YC L
Sbjct: 359 NPSYGALSDYQFMRARSRDKKLQEEWAIALNSVEDIYE---RFMNYCLGKL 406
>B9N8L0_POPTR (tr|B9N8L0) Methylenetetrahydrofolate reductase OS=Populus
trichocarpa GN=MTHFR2 PE=2 SV=1
Length = 606
Score = 725 bits (1872), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/406 (83%), Positives = 367/406 (90%), Gaps = 9/406 (2%)
Query: 1 MKVIEKVRXXX---------XXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFC 51
MKVI+K+R ++VVFSFEFFPPKT+DGVDNLFERMDRMV+HNPSFC
Sbjct: 1 MKVIDKIRAAAAAGDSNGGDSSSNNKVVFSFEFFPPKTDDGVDNLFERMDRMVSHNPSFC 60
Query: 52 DITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLA 111
DITWGAGGSTAD+TL+IANKMQNI+CVETM+HLTCTNMPVEKID+AL+TIKSNG+QNVLA
Sbjct: 61 DITWGAGGSTADLTLDIANKMQNIICVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLA 120
Query: 112 LRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATT 171
LRGDPPHGQDKFVQ +GG ACA DLVKHIR+KYGDYFGITVAGYPEAHPD IGSDG AT
Sbjct: 121 LRGDPPHGQDKFVQIQGGLACALDLVKHIRSKYGDYFGITVAGYPEAHPDVIGSDGFATL 180
Query: 172 EAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKG 231
E Y +L YLK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPINNYKG
Sbjct: 181 EDYHKDLAYLKQKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPINNYKG 240
Query: 232 FIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNM 291
FIRM GFCKTKIPAE+ AALEPIKDNEEAV+ YGIHLGTEMC+KILAHGIKTLHLYTLNM
Sbjct: 241 FIRMAGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNM 300
Query: 292 EKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQY 351
EKSALAIL +LGLIEESKI+R LPWR PTNVFRV+EDVRPIFWANRPKSY++RTIGWDQY
Sbjct: 301 EKSALAILMNLGLIEESKITRPLPWRPPTNVFRVKEDVRPIFWANRPKSYLTRTIGWDQY 360
Query: 352 PHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
PHGRWGDS NPSYGAL+DYQFMRPRAR KKL EEWA PL+S+EDIY
Sbjct: 361 PHGRWGDSRNPSYGALSDYQFMRPRARGKKLLEEWAAPLKSVEDIY 406
>J7EQB2_TOBAC (tr|J7EQB2) Methylenetetrahydrofolate reductase OS=Nicotiana
tabacum PE=2 SV=1
Length = 595
Score = 725 bits (1871), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/397 (85%), Positives = 369/397 (92%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +RVVFSFEFFPPKTEDGV+NLFERM+RMVAHNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAK-DENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+ +MQN+VCVETM+HLTCTNMPVEKID+AL TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC Q+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFRV+EDVRPIFWANRPKSYISRT+GWD+YPHGRWG++
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTLGWDEYPHGRWGNAQ 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMR R+RDKKL EEWAV L S++DIY
Sbjct: 360 NPSYGALTDYQFMRARSRDKKLQEEWAVALNSVDDIY 396
>J7EPI5_NICTO (tr|J7EPI5) Methylenetetrahydrofolate reductase OS=Nicotiana
tomentosiformis PE=2 SV=1
Length = 595
Score = 725 bits (1871), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/397 (85%), Positives = 369/397 (92%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +RVVFSFEFFPPKTEDGV+NLFERM+RMVAHNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAK-DENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+ +MQN+VCVETM+HLTCTNMPVEKID+AL TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC Q+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFRV+EDVRPIFWANRPKSYISRT+GWD+YPHGRWG++
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTLGWDEYPHGRWGNAQ 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMR R+RDKKL EEWAV L S++DIY
Sbjct: 360 NPSYGALTDYQFMRARSRDKKLQEEWAVALNSVDDIY 396
>F6I5I7_VITVI (tr|F6I5I7) Methylenetetrahydrofolate reductase OS=Vitis vinifera
GN=VIT_15s0024g00070 PE=2 SV=1
Length = 594
Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/396 (85%), Positives = 369/396 (93%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK+R + +VVFSFEFFPPKTEDGVDNLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIRDAATEE-GKVVFSFEFFPPKTEDGVDNLFERMDRMVAHGPAFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+NKMQN++CVETM+HLTCTNMPVEKID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISNKMQNMICVETMMHLTCTNMPVEKIDHALDTIKSNGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ +GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPD I +GVAT+EAYQ++L Y
Sbjct: 120 DKFVQIQGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDVI-LNGVATSEAYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP+E+ AALEPIKDN+EAVK YGIHLGTEMC+KILAHGIKT+HLYTLNMEKSALAIL
Sbjct: 239 TKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTVHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR PWRRPTNVFRV+EDVRPIFWANRP+SYISRTIGWDQYPHGRW DS
Sbjct: 299 NLGLIEESKISRPFPWRRPTNVFRVKEDVRPIFWANRPRSYISRTIGWDQYPHGRWSDSC 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYG LTDYQFMRPRARDKKL +EW VPL+SIED+
Sbjct: 359 NPSYGGLTDYQFMRPRARDKKLQDEWVVPLKSIEDV 394
>M1C552_SOLTU (tr|M1C552) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400023361 PE=3 SV=1
Length = 597
Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 339/407 (83%), Positives = 373/407 (91%), Gaps = 5/407 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D RVVFSFEFFPPKTEDGVDNLFERM+RMV+HNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+N+MQN+VCVETM+HLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKH+RAKYGDYFGITVAGYPEAHPD I + G+AT E Y+NEL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPATGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTD FLKFV+DC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIVTQLFYDTDNFLKFVSDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T+IPAEI AALEPIKDNEEAVK YGIHLGTEMC+KI+A GIKTLHLYTLNMEKSALAIL
Sbjct: 239 TRIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFR++EDVRPIFWANRPKSYISRTIGWD++PHGRWG++
Sbjct: 299 NLGLIEESKISRPLPWRRPTNVFRIKEDVRPIFWANRPKSYISRTIGWDEFPHGRWGNAK 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
NPSYGAL+DYQFMR R+RDKKL EEWA+ L S+EDIY ++ YC
Sbjct: 359 NPSYGALSDYQFMRARSRDKKLQEEWAIALNSVEDIYE---RFMNYC 402
>A5ATB7_VITVI (tr|A5ATB7) Methylenetetrahydrofolate reductase OS=Vitis vinifera
GN=VITISV_016119 PE=1 SV=1
Length = 594
Score = 724 bits (1868), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/396 (85%), Positives = 369/396 (93%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK+R + +VVFSFEFFPPKTEDGVDNLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIRDAATEE-GKVVFSFEFFPPKTEDGVDNLFERMDRMVAHGPAFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+NKMQN++CVETM+HLTCTNMPVEKID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISNKMQNMICVETMMHLTCTNMPVEKIDHALDTIKSNGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ +GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPD I +GVAT+EAYQ++L Y
Sbjct: 120 DKFVQIQGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDVI-LNGVATSEAYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP+E+ AALEPIKDN+EAVK YGIHLGTEMC+KILAHGIKT+HLYTLNMEKSALAIL
Sbjct: 239 TKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTVHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR PWRRPTNVFRV+EDVRPIFWANRP+SYISRTIGWDQYPHGRW DS
Sbjct: 299 NLGLIEESKISRPFPWRRPTNVFRVKEDVRPIFWANRPRSYISRTIGWDQYPHGRWSDSC 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYG LTDYQFMRPRARDKKL +EW VPL+SIED+
Sbjct: 359 NPSYGGLTDYQFMRPRARDKKLQDEWVVPLKSIEDV 394
>K4C2P8_SOLLC (tr|K4C2P8) Methylenetetrahydrofolate reductase OS=Solanum
lycopersicum GN=Solyc05g055730.2 PE=3 SV=1
Length = 596
Score = 723 bits (1867), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 338/407 (83%), Positives = 374/407 (91%), Gaps = 5/407 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D RVVFSFEFFPPKTEDGVDNLFERM+RMV+HNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+N+MQN+VCVETM+HLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKH+RAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+NEL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPANGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADL+VTQLFYDTD FLKFV+DC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLVVTQLFYDTDNFLKFVSDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T+IPAEI AALEPIKDNEEAVK YGIHLGTEMC+KI+A GIKTLHLYTLNMEKSALAIL
Sbjct: 239 TRIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFR++EDVRPIFWANRPKSYISRTIGWD++PHGRWG++
Sbjct: 299 NLGLIEESKISRLLPWRRPTNVFRIKEDVRPIFWANRPKSYISRTIGWDEFPHGRWGNAK 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
NPSYGAL+DYQFMR R+RDKKL EEWA+ L S+EDIY ++ YC
Sbjct: 359 NPSYGALSDYQFMRARSRDKKLQEEWAIALNSVEDIYE---RFMYYC 402
>J7EPV1_NICTO (tr|J7EPV1) Methylenetetrahydrofolate reductase OS=Nicotiana
tomentosiformis PE=2 SV=1
Length = 595
Score = 721 bits (1862), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 339/397 (85%), Positives = 368/397 (92%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +RVVFSFEFFPPKTEDGV+NLFERM+ MVAHNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQGAAK-DENRVVFSFEFFPPKTEDGVENLFERMEGMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+ +MQN+VCVETM+HLTCTNMPVEKID+AL TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC Q+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFRV+EDVRPIFWANRPKSYISRT+GWD+YPHGRWG++
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTLGWDEYPHGRWGNAQ 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMR R+RDKKL EEWAV L S++DIY
Sbjct: 360 NPSYGALTDYQFMRARSRDKKLQEEWAVALNSVDDIY 396
>J7EQB1_NICTO (tr|J7EQB1) Methylenetetrahydrofolate reductase OS=Nicotiana
tomentosiformis PE=2 SV=1
Length = 595
Score = 721 bits (1861), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 338/397 (85%), Positives = 367/397 (92%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +RVVFSFEFFPPKTEDGV+NLFERM+RMVAHNPSFCDITWGAGG
Sbjct: 1 MKVIEKIQEAAK-DENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGP 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+ +MQN+VCVETM+HLTCTNMPVEKID+AL TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC Q+GITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQLGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMA LEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPEEIMAVLEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFRV+EDVRPIFWANRPKSYISRT+GWD+YPHGRWG++
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTLGWDEYPHGRWGNAQ 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMR R+RDKKL EEWAV L S++DIY
Sbjct: 360 NPSYGALTDYQFMRARSRDKKLQEEWAVALNSVDDIY 396
>J7EQ04_NICSY (tr|J7EQ04) Methylenetetrahydrofolate reductase OS=Nicotiana
sylvestris PE=2 SV=1
Length = 595
Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 337/397 (84%), Positives = 367/397 (92%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +RVVFSFEFFPPKTEDGV+NLFERM+RMVAHNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAK-DENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+ +MQN+VCVETM+HLTCTNMPVEKID+AL TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNM+KSAL+IL
Sbjct: 240 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMKKSALSILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFRV+EDVRPIFWANRPKSYISRT+GWD+YPHGRWG++
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTLGWDEYPHGRWGNAQ 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGAL+DYQFMR R+RDKKL EEW V L S+ED Y
Sbjct: 360 NPSYGALSDYQFMRARSRDKKLQEEWVVALNSVEDTY 396
>J7EPU9_TOBAC (tr|J7EPU9) Methylenetetrahydrofolate reductase OS=Nicotiana
tabacum PE=2 SV=1
Length = 595
Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 337/397 (84%), Positives = 367/397 (92%), Gaps = 1/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +RVVFSFEFFPPKTEDGV+NLFERM+RMVAHNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAK-DENRVVFSFEFFPPKTEDGVENLFERMERMVAHNPSFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+ +MQN+VCVETM+HLTCTNMPVEKID+AL TIK NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLEISKRMQNMVCVETMMHLTCTNMPVEKIDHALDTIKINGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 120 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDVIPANGIATQEIYENDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKD+EEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSAL+IL
Sbjct: 240 TKIPEEIMAALEPIKDSEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKSALSILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFRV+EDVRPIFWANRPKSYISRT+GWD+YPHGRWG++
Sbjct: 300 NLGLIEESKISRPLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTLGWDEYPHGRWGNAQ 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGAL+DYQFMR R+RDKKL EEW V L S+ED Y
Sbjct: 360 NPSYGALSDYQFMRARSRDKKLQEEWVVALNSVEDTY 396
>M0TJL5_MUSAM (tr|M0TJL5) Methylenetetrahydrofolate reductase OS=Musa acuminata
subsp. malaccensis PE=3 SV=1
Length = 595
Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 336/411 (81%), Positives = 368/411 (89%), Gaps = 4/411 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K+R D R VFSFEFFPPKTE+GV+NLFERMDRMVAHNP+FCDITWGAGGS
Sbjct: 1 MKVIDKIRAATEGD-GRTVFSFEFFPPKTEEGVENLFERMDRMVAHNPTFCDITWGAGGS 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IAN+MQN++CVETM+HLTCTNMPVEKID+AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 60 TADLTLDIANRMQNMICVETMMHLTCTNMPVEKIDHALDTIKANGIQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPD I DG AT EAY ++L Y
Sbjct: 120 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDMIQGDGGATLEAYNSDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTD FLKFVNDC QIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 180 LKRKVDAGADLIITQLFYDTDNFLKFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP+EI AALEPIKDNEEAV+ YGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAIL
Sbjct: 240 TKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+ GLIEESK+SRSLPWRRP N+FRV+EDVRPIFWANRPKSYISRT+GWDQYPHGRWGDS
Sbjct: 300 NFGLIEESKVSRSLPWRRPANIFRVKEDVRPIFWANRPKSYISRTVGWDQYPHGRWGDSN 359
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
NPSYGALTDYQFMRPR+RDKK EEWA PL+S DI ++++C L
Sbjct: 360 NPSYGALTDYQFMRPRSRDKKFQEEWATPLKSAADI---NERFMKFCLGKL 407
>Q10BJ7_ORYSJ (tr|Q10BJ7) Methylenetetrahydrofolate reductase OS=Oryza sativa
subsp. japonica GN=Os03g0815200 PE=3 SV=1
Length = 594
Score = 717 bits (1852), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 339/396 (85%), Positives = 362/396 (91%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R VFSFE+FPPKTE+G+DNLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAADG--RTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIAN+MQN+VCVETM+HLTCTNMPVEKID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPDAI S AT EAY N+L Y
Sbjct: 119 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI AALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSAL IL
Sbjct: 239 TKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISRSLPWR PTNVFRV+EDVRPIFWANRPKSYISRT+GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTDYQF RPR R KKL EEWAVP++S+EDI
Sbjct: 359 NPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDI 394
>A2XNC0_ORYSI (tr|A2XNC0) Methylenetetrahydrofolate reductase OS=Oryza sativa
subsp. indica GN=OsI_14054 PE=2 SV=1
Length = 594
Score = 717 bits (1852), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 339/396 (85%), Positives = 362/396 (91%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R VFSFE+FPPKTE+G+DNLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAADG--RTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIAN+MQN+VCVETM+HLTCTNMPVEKID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPDAI S AT EAY N+L Y
Sbjct: 119 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI AALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSAL IL
Sbjct: 239 TKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISRSLPWR PTNVFRV+EDVRPIFWANRPKSYISRT+GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTDYQF RPR R KKL EEWAVP++S+EDI
Sbjct: 359 NPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDI 394
>Q10BJ6_ORYSJ (tr|Q10BJ6) Methylenetetrahydrofolate reductase OS=Oryza sativa
subsp. japonica GN=LOC_Os03g60090 PE=2 SV=1
Length = 573
Score = 717 bits (1851), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 339/396 (85%), Positives = 362/396 (91%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R VFSFE+FPPKTE+G+DNLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAADG--RTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIAN+MQN+VCVETM+HLTCTNMPVEKID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPDAI S AT EAY N+L Y
Sbjct: 119 DKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI AALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSAL IL
Sbjct: 239 TKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISRSLPWR PTNVFRV+EDVRPIFWANRPKSYISRT+GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTDYQF RPR R KKL EEWAVP++S+EDI
Sbjct: 359 NPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDI 394
>B9STA4_RICCO (tr|B9STA4) Methylenetetrahydrofolate reductase OS=Ricinus communis
GN=RCOM_0364940 PE=3 SV=1
Length = 609
Score = 715 bits (1846), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 336/410 (81%), Positives = 367/410 (89%), Gaps = 13/410 (3%)
Query: 1 MKVIEKVRXXXXXDP-------------DRVVFSFEFFPPKTEDGVDNLFERMDRMVAHN 47
MKVI+K++ D+VVFSFEFFPPKTEDGVDNLF+RMDRMV+HN
Sbjct: 1 MKVIDKIKASVGASSHPHSNGGAISDSNDKVVFSFEFFPPKTEDGVDNLFDRMDRMVSHN 60
Query: 48 PSFCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQ 107
P+FCDITWGAGGSTAD+TL+IANKMQN++CVETM+HLTCTNMPVEKID+ALQTIKSNG+Q
Sbjct: 61 PTFCDITWGAGGSTADLTLDIANKMQNMICVETMMHLTCTNMPVEKIDHALQTIKSNGIQ 120
Query: 108 NVLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDG 167
NVLALRGDPPHGQDKFVQ EGGFACA DLVKHIR+KYGDYFGITVAGYPEAHPD I SDG
Sbjct: 121 NVLALRGDPPHGQDKFVQVEGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDMIESDG 180
Query: 168 VATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPIN 227
+AT E YQ +L YLK KVDAGADLI+TQLFYDTDIFLKFVNDC QIGI CPIVPGIMPIN
Sbjct: 181 LATPENYQRDLEYLKRKVDAGADLIITQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPIN 240
Query: 228 NYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLY 287
NYKGF+RMTGFCKTKIPAE+ AALEPIKDNEEAV+ YGIHLGTEMC+KI+AHGIKTLHLY
Sbjct: 241 NYKGFLRMTGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKIMAHGIKTLHLY 300
Query: 288 TLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIG 347
TLNMEKSALAIL +LGLIEESKISR LPWR PTNVFRV+E VRPIFWANRPKSYISRT+G
Sbjct: 301 TLNMEKSALAILMNLGLIEESKISRPLPWRPPTNVFRVKEGVRPIFWANRPKSYISRTLG 360
Query: 348 WDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
W+QYP GRWGDS NPSYGAL+D+QFMRPRARDKKL +EW VPL S EDI+
Sbjct: 361 WEQYPQGRWGDSCNPSYGALSDHQFMRPRARDKKLHDEWVVPLSSAEDIF 410
>M1BBU4_SOLTU (tr|M1BBU4) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400016168 PE=3 SV=1
Length = 594
Score = 714 bits (1842), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/397 (83%), Positives = 365/397 (91%), Gaps = 2/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +V+FSFEFFPPKT+DGV+NLFERM+RMVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAKTD--KVIFSFEFFPPKTDDGVENLFERMERMVAHSPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I N+MQN+VCVE+M+HLTCTNMPVEKID+AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIVNRMQNMVCVESMMHLTCTNMPVEKIDHALDTIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKH+RAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPANGIATKEIYENDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+IVTQLFYDTD+FLKFVNDC QIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKKKVDAGADVIVTQLFYDTDVFLKFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSALAIL
Sbjct: 239 TKIPEEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRP NVFRV+EDVRPIFWANRPKSYISRT GWD+YPHGRW ++
Sbjct: 299 NLGLIEESKISRPLPWRRPANVFRVKEDVRPIFWANRPKSYISRTTGWDEYPHGRWSNAQ 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMR R+RDKKL EEWAV L S+EDIY
Sbjct: 359 NPSYGALTDYQFMRARSRDKKLQEEWAVALNSVEDIY 395
>K4D5E7_SOLLC (tr|K4D5E7) Methylenetetrahydrofolate reductase OS=Solanum
lycopersicum GN=Solyc11g008870.1 PE=3 SV=1
Length = 594
Score = 712 bits (1838), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 331/397 (83%), Positives = 363/397 (91%), Gaps = 2/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D +V+FSFEFFPPKT+DGV+NLFERM+RMVAH PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAKTD--KVIFSFEFFPPKTDDGVENLFERMERMVAHGPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI N+MQN+VCVE+M+HLTCTNMPVEKID+AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIVNRMQNMVCVESMMHLTCTNMPVEKIDHALDTIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKH+RAKYGDYFGITVAGYPEAHPD I ++G+AT E Y+N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPANGIATKEIYENDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+IVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKKKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP EIMAALEPIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEKSALAIL
Sbjct: 239 TKIPDEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRP N+FRV+EDVRPIFWANRPKSYISRT GWD+YPHGRW ++
Sbjct: 299 NLGLIEESKISRPLPWRRPANIFRVKEDVRPIFWANRPKSYISRTTGWDEYPHGRWSNAQ 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
NPSYGALTDYQFMR R+RDKKL EEWA L S+EDIY
Sbjct: 359 NPSYGALTDYQFMRARSRDKKLQEEWAAALNSVEDIY 395
>J3LU35_ORYBR (tr|J3LU35) Methylenetetrahydrofolate reductase OS=Oryza
brachyantha GN=OB03G45610 PE=3 SV=1
Length = 594
Score = 710 bits (1833), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 333/396 (84%), Positives = 359/396 (90%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK+R R VFSFE+FPPKTE+G+DNLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIREAAADG--RTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIAN+MQN+VCVETM+HLTCTNMPVE ID AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVENIDEALTTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGFACA DLV+HI+AKYGDYFGITVAGYPEAHP+ I S AT EAY N+L Y
Sbjct: 119 DKFVQVSGGFACALDLVRHIKAKYGDYFGITVAGYPEAHPEVIHSAEGATLEAYSNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI AAL+PIKDNEEAVK YGIHLGTEMC+K+LA GIKTLHLYTLNMEKSAL IL
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKVLASGIKTLHLYTLNMEKSALGILQ 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESK++RSLPWR PTNVFRV+EDVRPIFWANRPKSYISRT+GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKVARSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTDYQF RPR R KKL EEWAVPL+S+EDI
Sbjct: 359 NPSYGALTDYQFTRPRGRGKKLQEEWAVPLKSVEDI 394
>C5WVY7_SORBI (tr|C5WVY7) Methylenetetrahydrofolate reductase OS=Sorghum bicolor
GN=Sb01g003700 PE=3 SV=1
Length = 593
Score = 707 bits (1826), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 332/396 (83%), Positives = 361/396 (91%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R FSFE+FPPKTE+GV+NLFERMDRMVAH PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAGNG--RTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIAN+MQN+VCVETM+HLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLV+HIRAKYGDYFGITVAGYPEAHPDAI +G AT EAY N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATLEAYSNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP+EI AAL+PIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNM+KSA+ IL
Sbjct: 239 TKIPSEITAALDPIKDNEEAVKQYGIHLGTEMCKKILATGIKTLHLYTLNMDKSAIGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESK+SR LPWR TNVFRV+EDVRPIFWANRPKSY+ RT+GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANRPKSYLKRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTD+QF RPR R KKL EEWAVPL+S+EDI
Sbjct: 359 NPSYGALTDHQFTRPRGRGKKLQEEWAVPLKSVEDI 394
>I1GLP9_BRADI (tr|I1GLP9) Methylenetetrahydrofolate reductase OS=Brachypodium
distachyon GN=BRADI1G04140 PE=3 SV=1
Length = 594
Score = 704 bits (1816), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/396 (83%), Positives = 360/396 (90%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R VFSFE+FPP+TE+GV+NLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAANG--RTVFSFEYFPPRTEEGVENLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TADVTL+IAN+MQN+VCVETM+HLTCTNMPVEKID+AL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDSALDTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGF+CA DLV+HI+AKYGDYFGITVAGYPEAHP+ I + AT EAY N+L Y
Sbjct: 119 DKFVQVAGGFSCALDLVQHIKAKYGDYFGITVAGYPEAHPEVILGEEGATEEAYSNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTD+FLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDMFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI AAL+PIKDNEEAVK YGIHLGTEMC+KILA GI TLHLYTLNMEK+ALAIL
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGINTLHLYTLNMEKTALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESK+SR+LPWR PTNVFRV+EDVRPIFWANRPKSYISRT+GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTDYQF RPR KKL EEWAVPL+S++DI
Sbjct: 359 NPSYGALTDYQFTRPRGSGKKLQEEWAVPLKSVQDI 394
>N1QRS8_AEGTA (tr|N1QRS8) Putative methylenetetrahydrofolate reductase
OS=Aegilops tauschii GN=F775_28470 PE=4 SV=1
Length = 594
Score = 703 bits (1814), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/396 (83%), Positives = 359/396 (90%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R VFSFE+FPPKTE+GV+NLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAANG--RTVFSFEYFPPKTEEGVENLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TADVTL+IAN+MQN+VCVETM+HLTCTNMPVEKIDNAL TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ GGF+CA DLV+HI+AKYGDYFGITVAGYPEAHP+ I + AT EAY +L Y
Sbjct: 119 DKFVQVAGGFSCALDLVEHIKAKYGDYFGITVAGYPEAHPEVILGEEGATEEAYSKDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+IVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI AAL+PIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEK+ALAIL
Sbjct: 239 TKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESK+SR+LPWR PTNVFRV+EDVRPIFWANRPKSYISRT GWDQYPHGRWGDS
Sbjct: 299 NLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGAL D+QF RPR R KKL EEWAVPL+S++DI
Sbjct: 359 NPSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDI 394
>R0HRY0_9BRAS (tr|R0HRY0) Uncharacterized protein OS=Capsella rubella
GN=CARUB_v10022865mg PE=4 SV=1
Length = 594
Score = 697 bits (1800), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 318/396 (80%), Positives = 361/396 (91%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K++ D + FSFEFFPPKTEDGVDNLFERMDRMVA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIQSLA--DEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA++MQN+VCVE+M+HLTCTNMPVEKID+AL+TI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGF CA DLV HIR+KYGDYFGITVAGYPEAHPD IG +G+A+ EAYQ++L Y
Sbjct: 119 DKFVQVEGGFGCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTD+FL+FVNDC QIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDVFLRFVNDCRQIGINCPIVPGIMPINNYKGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP E+MAALEPIKDNEEAVK YGIHLGTEMC+ ILAHGIK+LHLYTLNMEKSALAIL
Sbjct: 239 TKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKTILAHGIKSLHLYTLNMEKSALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LG+I+ESKISRSLPWRRP N+FR +EDVRPIFWANRPKSYISRT GW+ +P GRWGDS
Sbjct: 299 NLGMIDESKISRSLPWRRPANIFRTKEDVRPIFWANRPKSYISRTKGWEDFPQGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ SYGAL+D+QF RPRARDKKL +EW VPL+S++DI
Sbjct: 359 SASYGALSDHQFSRPRARDKKLQQEWVVPLKSVKDI 394
>D7LKW5_ARALL (tr|D7LKW5) Methylenetetrahydrofolate reductase OS=Arabidopsis
lyrata subsp. lyrata GN=ARALYDRAFT_483539 PE=3 SV=1
Length = 594
Score = 697 bits (1800), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 318/396 (80%), Positives = 361/396 (91%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K++ D + FSFEFFPPKTEDGVDNLFERMDRMVA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIQSLA--DEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA++MQN+VCVE+M+HLTCTNMPVEKID+AL+TI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGF CA DLV HIR+KYGDYFGITVAGYPEAHPD IG +G+A+ EAYQ++L Y
Sbjct: 119 DKFVQVEGGFGCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGADLIVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPINNY+GF+RMTGFCK
Sbjct: 179 LKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPINNYRGFLRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP E+MAALEPIKDNEEAVK YGIHLGTEMC+K+LAHG+K+LHLYTLNMEK ALAIL
Sbjct: 239 TKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKLALAILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LG+I+ESKISRSLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +P GRWGDS
Sbjct: 299 NLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWEDFPQGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ SYGAL+D+QF RPRARDKKL +EW VPL+S+EDI
Sbjct: 359 SASYGALSDHQFSRPRARDKKLEQEWVVPLKSVEDI 394
>M7ZYT1_TRIUA (tr|M7ZYT1) Putative methylenetetrahydrofolate reductase
OS=Triticum urartu GN=TRIUR3_34128 PE=4 SV=1
Length = 586
Score = 692 bits (1787), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 321/380 (84%), Positives = 349/380 (91%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R V FE+FPPKTE+GV+NLFERMDRMVAH P+FCDITWGAGGSTADVTL+IAN+MQN+V
Sbjct: 7 RTVLYFEYFPPKTEEGVENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQNMV 66
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
CVETM+HLTCTNMPVEKIDNAL TIKSNG+QNVLALRGDPPHGQDKFVQ GGF+CA DL
Sbjct: 67 CVETMMHLTCTNMPVEKIDNALDTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFSCALDL 126
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V+HI+AKYGDYFGITVAGYPEAHP+ I + AT EAY +L YLK KVDAGAD+IVTQL
Sbjct: 127 VEHIKAKYGDYFGITVAGYPEAHPEVILGEEGATEEAYSKDLAYLKRKVDAGADVIVTQL 186
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFCKTKIPAEI AAL+PIKD
Sbjct: 187 FYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKD 246
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPW 316
NEEAVK YGIHLGTEMC+KILA GIKTLHLYTLNMEK+ALAIL +LGLIEESK+SR+LPW
Sbjct: 247 NEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPW 306
Query: 317 RRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPR 376
R PTNVFRV+EDVRPIFWANRPKSYISRT GWDQYPHGRWGDS NPSYGAL D+QF RPR
Sbjct: 307 RPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPHGRWGDSRNPSYGALNDHQFTRPR 366
Query: 377 ARDKKLTEEWAVPLRSIEDI 396
R KKL EEWAVPL+S++DI
Sbjct: 367 GRGKKLQEEWAVPLKSVQDI 386
>K4AMY6_SETIT (tr|K4AMY6) Methylenetetrahydrofolate reductase OS=Setaria italica
GN=Si040282m.g PE=3 SV=1
Length = 592
Score = 692 bits (1786), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/396 (83%), Positives = 356/396 (89%), Gaps = 5/396 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R FSFE+FPPKTE+GV+NLFERMDRMVAH PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQQAAADG--RTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IAN+MQN+VCVE+M+HLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDIANRMQNMVCVESMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIRAKYGDYFGITVAGYPEAHPDAI +G AT EAY N+L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATPEAYNNDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFV+DC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVDDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEI ALEPIK+NEEAVK YG+HLGTEMC+KILA GIKTLHLYTLNMEKSA+ IL
Sbjct: 239 TKIPAEITDALEPIKENEEAVKEYGVHLGTEMCKKILASGIKTLHLYTLNMEKSAIEILK 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
LGLIEE K+SR LPWR PTNVFRV+EDVRPIFWANRPKSYI RT+GWDQYPHGRWGDS
Sbjct: 299 RLGLIEEFKVSRPLPWRPPTNVFRVKEDVRPIFWANRPKSYIRRTLGWDQYPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
NPSYGALTD+Q R R KKL EEWAVPL+S+EDI
Sbjct: 359 NPSYGALTDHQ---TRGRGKKLQEEWAVPLKSVEDI 391
>M4F9A1_BRARP (tr|M4F9A1) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra037664 PE=3 SV=1
Length = 595
Score = 688 bits (1775), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 312/397 (78%), Positives = 360/397 (90%), Gaps = 2/397 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K++ D + FSFEFFPP+TEDGVDNLFERMDR+VA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIKSWT--DEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I ++MQN+VCVE+M+HLTCTNMPVEKID+AL+TI+SNG+QNVLALRGDPPHG+
Sbjct: 59 TADLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGE 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+KFVQ EGGF CA DLV HIR+KYGDYFGI V+GYPEAHPD IG +G+A+ EAYQ++L Y
Sbjct: 119 NKFVQVEGGFGCALDLVNHIRSKYGDYFGIAVSGYPEAHPDVIGENGLASKEAYQSDLEY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLF+DTD+ LKFVNDC QIGI CPIVPGIMPINNYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFFDTDMLLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMIGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+MAALEPI+DNEEAVK YGIHLGTEMC+KILAHGIK+LHLYTLNMEKSAL+IL
Sbjct: 239 TKIPAEVMAALEPIQDNEEAVKAYGIHLGTEMCKKILAHGIKSLHLYTLNMEKSALSILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LG+IEESKISRSLPWRRP NVFR++EDVRPIFWANRPKSYISRT W+ +P GRWGDS
Sbjct: 299 NLGMIEESKISRSLPWRRPANVFRIKEDVRPIFWANRPKSYISRTKAWENFPQGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
+ SYGALTD+QF RPRARDKKL +EW VPL+S+EDI+
Sbjct: 359 SASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIH 395
>M4CTF4_BRARP (tr|M4CTF4) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra007497 PE=3 SV=1
Length = 592
Score = 685 bits (1768), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 311/396 (78%), Positives = 358/396 (90%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV++K++ + + FSFEFFPPKTEDGV+NLFERMDR+V++ PSFCDITWGAGGS
Sbjct: 1 MKVVDKIKSAT--EQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIA++MQN++CVETM+HLTCTNMPVEKID+AL+TI+SNG+QNVLALRGDPPHG+
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGE 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLV H+R+KYGDYFGITVAGYPEAHPD I +DG+AT E+YQ++L Y
Sbjct: 119 DKFVQVEGGFACALDLVNHVRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC +IGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRKIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+ AALEPIKDNEEAVK +GIH TEMC+KILAHGI TLHLYTLNM+KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHLYTLNMDKSAIGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ESKI+RSLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +P GRWGDS
Sbjct: 299 NLGLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ SYG L+DYQFMRPRARDKKL +EW VPL+SIED+
Sbjct: 359 SASYGTLSDYQFMRPRARDKKLQQEWVVPLKSIEDV 394
>R0FNP9_9BRAS (tr|R0FNP9) Uncharacterized protein OS=Capsella rubella
GN=CARUB_v10016903mg PE=4 SV=1
Length = 592
Score = 683 bits (1762), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 310/396 (78%), Positives = 357/396 (90%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV++K++ + + FSFEFFPPKTEDGV+NLFERMDR+V++ P+FCDITWGAGGS
Sbjct: 1 MKVVDKIKSVT--EQGKTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIA++MQN++CVETM+HLTCTNMPVEKID+AL+TI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLV HIR KYGDYFGITVAGYPEAHPD I ++G+AT E+YQ++L Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRTKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+ AALEPIKDN+EAVK YGIH TEMC+KILAHGI TLHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITTLHLYTLNVDKSAIGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ESKISRSLPWRRP NVFR+ EDVRPIFWANRPKSYISRT GW+ +PHGRWGDS
Sbjct: 299 NLGLIDESKISRSLPWRRPANVFRISEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ SY L+DYQFMRP+ARDKKL +EW VPL+SI+D+
Sbjct: 359 SASYSTLSDYQFMRPKARDKKLQQEWVVPLKSIDDV 394
>M4CGR4_BRARP (tr|M4CGR4) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra003397 PE=3 SV=1
Length = 592
Score = 680 bits (1755), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 310/396 (78%), Positives = 355/396 (89%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV++K++ + + FSFEFFPPKTEDGV+NLFERMDR+V++ PSFCDITWGAGGS
Sbjct: 1 MKVVDKIKSVT--EQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIA++MQN +CVETM+HLTCTNMPVEKID+AL+TI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLV HIR+KYGDYFGITVAGYPEAHPD I ++G+AT E+YQ++L Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+ AALEPIKDNEEAVK YGIH TEMC+KILAHGI TLH+YTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNEEAVKAYGIHFATEMCKKILAHGITTLHIYTLNVDKSAIGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ESKI+RSLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +P GRWGDS
Sbjct: 299 NLGLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ SY L+DYQFMRPRARDKKL +EW VPL+ IED+
Sbjct: 359 SASYSTLSDYQFMRPRARDKKLQQEWVVPLKGIEDV 394
>D7LWJ5_ARALL (tr|D7LWJ5) Methylenetetrahydrofolate reductase OS=Arabidopsis
lyrata subsp. lyrata GN=ARALYDRAFT_486463 PE=3 SV=1
Length = 592
Score = 680 bits (1754), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 308/396 (77%), Positives = 357/396 (90%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV++K++ + + FSFEFFPPKTEDGV+NLFERMDR+V++ P+FCDITWGAGGS
Sbjct: 1 MKVVDKIKSVT--EQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIA++MQN++CVETM+HLTCTNMP+EKID+AL+TI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLV HIR+KYGDYFGITVAGYPEAHPD I ++G+AT E+YQ++L Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+ AALEPIKDN+EAVK YGIH TEMC+KILAHGI TLHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITTLHLYTLNVDKSAIGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ESKISRSLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +PHGRWGD+
Sbjct: 299 NLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDTR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ SY L+DYQF RP+ARDKKL +EW VPL+SIED+
Sbjct: 359 SASYSTLSDYQFTRPKARDKKLQQEWVVPLKSIEDV 394
>F4JAK1_ARATH (tr|F4JAK1) Methylenetetrahydrofolate reductase OS=Arabidopsis
thaliana GN=MTHFR1 PE=2 SV=1
Length = 407
Score = 677 bits (1748), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 307/396 (77%), Positives = 356/396 (89%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV++K++ + + FSFEFFPPKTEDGV+NLFERMDR+V++ P+FCDITWGAGGS
Sbjct: 1 MKVVDKIKSVT--EQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIA++MQN++CVETM+HLTCTNMP+EKID+AL+TI+SNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLV HIR+KYGDYFGITVAGYPEAHPD I +DG+AT E+YQ++L Y
Sbjct: 119 DKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPI+NYKGF+RM GFCK
Sbjct: 179 LKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+ AALEPIKDN+EAVK YGIH TEMC+KILAHGI +LHLYTLN++KSA+ IL
Sbjct: 239 TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILM 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ESKISRSLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +PHGRWGDS
Sbjct: 299 NLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSH 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+ +Y L+DYQF RP+ RDKKL +EW VPL+SIED+
Sbjct: 359 SAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDV 394
>G3C900_PINPS (tr|G3C900) Methylenetetrahydrofolate reductase OS=Pinus pinaster
GN=mthfr PE=2 SV=1
Length = 594
Score = 673 bits (1737), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 314/396 (79%), Positives = 352/396 (88%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ +VVFSFEFFPPKTE GV+NLF+RMD+MV H PSFCDITWGAGGS
Sbjct: 1 MKVIEKLQNAEKEG--KVVFSFEFFPPKTEGGVENLFDRMDQMVEHQPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+NKMQN++CVETM+HLTCTNMPVEKID+AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDISNKMQNMICVETMMHLTCTNMPVEKIDHALTTIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIR+KYGDYFGITVAGYPEAHPD I +D AT E YQ +L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDMIKNDMGATEEDYQKDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDI+LKFVNDC QIGI CPIVPGIMPIN Y GFIRM GFCK
Sbjct: 179 LKSKVDAGADLIITQLFYDTDIYLKFVNDCRQIGIKCPIVPGIMPINTYGGFIRMVGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP+EI AALEPIKDNEEAV+ YGIHLGTEMC+KILAHGIKTLHLYTLNM+KSALAIL
Sbjct: 239 TKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMDKSALAILG 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ +KI RSLPWR TNV R +E+VRPIFWANRP+SYISRTI W+Q+PHGRWGD+
Sbjct: 299 NLGLIDMTKIRRSLPWRPATNVLRTKENVRPIFWANRPRSYISRTISWEQFPHGRWGDTR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+P+YGAL DYQF+R R+R KK+ EEW VPL SIEDI
Sbjct: 359 SPAYGALNDYQFLRRRSRSKKILEEWVVPLSSIEDI 394
>B8LKP0_PICSI (tr|B8LKP0) Methylenetetrahydrofolate reductase OS=Picea sitchensis
PE=1 SV=1
Length = 594
Score = 671 bits (1731), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 312/396 (78%), Positives = 352/396 (88%), Gaps = 2/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ +VVFSFEFFPPKTE+GV+NLF+RMDRMV H PSFCDITWGAGGS
Sbjct: 1 MKVIEKIQNAEKEG--KVVFSFEFFPPKTEEGVENLFDRMDRMVEHQPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+I+NKMQN++CVE+M+HLTCTNMPVEKID+AL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLDISNKMQNMICVESMMHLTCTNMPVEKIDHALATIKANGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKHIR+KYGDYFGITVAGYPEAHPD I ++ AT E YQ +L Y
Sbjct: 119 DKFVQVEGGFACALDLVKHIRSKYGDYFGITVAGYPEAHPDMIKNEVGATEEDYQKDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQLFYDTDI+LKFVNDC QIGI CPIVPGIMPINNYKGFIRM GFCK
Sbjct: 179 LKLKVDAGADLIITQLFYDTDIYLKFVNDCRQIGIKCPIVPGIMPINNYKGFIRMAGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIP+EI AALEPIKDNEEAV+ YGIHLGTEMC+KILAHGIKTLHLYTLNMEKSAL IL
Sbjct: 239 TKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALGILA 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ +KI R LPWR TNV R +E+VRPIFWANRP+SYISRTIGW+Q+P+GRWGD+
Sbjct: 299 NLGLIDMTKIRRPLPWRPATNVLRTKENVRPIFWANRPRSYISRTIGWEQFPNGRWGDAR 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+P+YGAL DYQF+R R+R KK+ EEW VPL SI DI
Sbjct: 359 SPAYGALNDYQFLRRRSRSKKILEEWVVPLSSIVDI 394
>A6XMY8_TRIMO (tr|A6XMY8) Methylenetetrahydrofolate reductase OS=Triticum
monococcum PE=1 SV=1
Length = 582
Score = 669 bits (1727), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 311/366 (84%), Positives = 339/366 (92%)
Query: 31 DGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMP 90
+GV+NLFERMDRMVAH P+FCDITWGAGGSTADVTL+IAN+MQN+VCVETM+HLTCTNMP
Sbjct: 17 EGVENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQNMVCVETMMHLTCTNMP 76
Query: 91 VEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGI 150
VEKIDNAL TIKSNG+QNVLALRGDPPHGQDKFVQ GGF+CA DLV+HI+AKYGDYFGI
Sbjct: 77 VEKIDNALDTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFSCALDLVEHIKAKYGDYFGI 136
Query: 151 TVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDC 210
TVAGYPEAHP+ I + AT EAY+ +L YLK KVDAGAD+IVTQLFYDTDIFLKFVNDC
Sbjct: 137 TVAGYPEAHPEVILGEEGATEEAYRKDLAYLKRKVDAGADVIVTQLFYDTDIFLKFVNDC 196
Query: 211 LQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGT 270
QIGITCPIVPGIMPINNYKGF+RMTGFCKTKIPAEI AAL+PIKDNEEAVK YGIHLGT
Sbjct: 197 RQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGT 256
Query: 271 EMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVR 330
EMC+KILA GIKTLHLYTLNMEK+ALAIL +LGLIEESK+SR+LPWR PTNVFRV+EDVR
Sbjct: 257 EMCKKILASGIKTLHLYTLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVR 316
Query: 331 PIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPL 390
PIFWANRPKSYISRT GWDQYPHGRWGDS NPSYGAL D+QF RPR R KKL EEWAVPL
Sbjct: 317 PIFWANRPKSYISRTTGWDQYPHGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPL 376
Query: 391 RSIEDI 396
+S++DI
Sbjct: 377 KSVQDI 382
>M0RR35_MUSAM (tr|M0RR35) Methylenetetrahydrofolate reductase OS=Musa acuminata
subsp. malaccensis PE=3 SV=1
Length = 554
Score = 665 bits (1715), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 307/369 (83%), Positives = 339/369 (91%), Gaps = 3/369 (0%)
Query: 43 MVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIK 102
MVAHNP+FCDITWGAGGSTAD+TL+IAN+MQN++CVETM+HLTCTNMPVEKID+AL TIK
Sbjct: 1 MVAHNPNFCDITWGAGGSTADLTLDIANRMQNMICVETMMHLTCTNMPVEKIDHALDTIK 60
Query: 103 SNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDA 162
+NG+QNVLALRGDPPHGQDKFVQ GGFACA DLV+HIRAKYGDYFGITVAGYPEAHPD
Sbjct: 61 ANGIQNVLALRGDPPHGQDKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDM 120
Query: 163 IGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPG 222
I DG AT EAY N+L YLK KVDAGADLI+TQLFYDTDIFLKFVNDC QIGITCPIVPG
Sbjct: 121 IQGDGGATQEAYNNDLAYLKRKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPG 180
Query: 223 IMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIK 282
IMPINNYKGF+RMTGFCKTKIP EI AAL+PIKDNE+AV+ YG+HLGTEMC+KIL+HGIK
Sbjct: 181 IMPINNYKGFLRMTGFCKTKIPPEITAALDPIKDNEDAVRAYGVHLGTEMCKKILSHGIK 240
Query: 283 TLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYI 342
TLHLYTLNMEKSALAIL +LGLIEESK+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYI
Sbjct: 241 TLHLYTLNMEKSALAILMNLGLIEESKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYI 300
Query: 343 SRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLL 402
SRT+GWDQYPHGRWGDS NPSYGALTDYQFMRPR+RDKKL EEWA PL+S++DI
Sbjct: 301 SRTVGWDQYPHGRWGDSNNPSYGALTDYQFMRPRSRDKKLQEEWATPLKSVDDI---NER 357
Query: 403 YLQYCYSFL 411
++++C L
Sbjct: 358 FMKFCLGKL 366
>D8RDX1_SELML (tr|D8RDX1) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_146279 PE=3 SV=1
Length = 594
Score = 649 bits (1673), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 294/396 (74%), Positives = 345/396 (87%), Gaps = 3/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
M++++K++ + R +FSFE+FPPKT++GV+NLFERMDRMV H P+FCDITWGAGGS
Sbjct: 1 MRIVDKIKDAQREN--RTIFSFEYFPPKTDEGVENLFERMDRMVMHQPAFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+TLEI NKMQN++CVE+M+HLTCTNMPV K+D AL +K+NG+QN+LALRGDPPHGQ
Sbjct: 59 TSDLTLEIVNKMQNMICVESMMHLTCTNMPVSKLDFALGNVKANGVQNILALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ E GF+CA DLVKHIR KYG YFGITVAGYPEAHPD I D AT EAY+ +L Y
Sbjct: 119 DKFVQVEDGFSCALDLVKHIRKKYGGYFGITVAGYPEAHPDVISGDA-ATQEAYEKDLAY 177
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG D I+TQLFYDTD+FL+FVNDC +IGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 178 LKEKVDAGGDFIITQLFYDTDLFLRFVNDCREIGITCPIVPGIMPINNYKGFLRMTGFCK 237
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+I AALEPIKDN+EAV+ +G+HLGTEMC+KILA GI +HLYTLNMEKSA+AIL
Sbjct: 238 TKIPADITAALEPIKDNDEAVRSFGVHLGTEMCKKILASGINAVHLYTLNMEKSAIAILQ 297
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ S++ RSLPWR PTNV R REDVRPIFWANRPKSYISRT WDQYP GRWGDS
Sbjct: 298 NLGLIDISQVRRSLPWRPPTNVRRTREDVRPIFWANRPKSYISRTTAWDQYPSGRWGDSR 357
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+P+YGALTDYQF+R R+R+KK+ EEW VPL S+EDI
Sbjct: 358 SPAYGALTDYQFLRRRSRNKKIQEEWVVPLSSVEDI 393
>D8QNN7_SELML (tr|D8QNN7) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_140106 PE=3 SV=1
Length = 594
Score = 647 bits (1670), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 292/396 (73%), Positives = 345/396 (87%), Gaps = 3/396 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
M++++K++ + R +FSFE+FPPKT++GV+NLFERMDRMV H P+FCDITWGAGGS
Sbjct: 1 MRIVDKIKDAQREN--RTIFSFEYFPPKTDEGVENLFERMDRMVMHQPAFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+TLEI NKMQN++CVE+M+HLTCTNMPV K+D AL+ +K+NG+QN+LALRGDPPHGQ
Sbjct: 59 TSDLTLEIVNKMQNMICVESMMHLTCTNMPVSKLDFALENVKANGVQNILALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ E GF+CA DLVKHIR KYG YFGITVAGYPEAHPD I D AT EAY+ +L Y
Sbjct: 119 DKFVQVEDGFSCALDLVKHIRKKYGGYFGITVAGYPEAHPDVISGDA-ATQEAYEKDLAY 177
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG D ++TQLFYDTD+FL+FVNDC +IGITCPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 178 LKEKVDAGGDFVITQLFYDTDLFLRFVNDCREIGITCPIVPGIMPINNYKGFLRMTGFCK 237
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T IPA+I AALEPIKDN+EAV+ +G+HLGTEMC+KILA GI +HLYTLNMEKSA+AIL
Sbjct: 238 TNIPADITAALEPIKDNDEAVRSFGVHLGTEMCKKILASGINAVHLYTLNMEKSAIAILQ 297
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ S++ RSLPWR PTNV R REDVRPIFWANRPKSYISRT WDQYP GRWGDS
Sbjct: 298 NLGLIDISQVRRSLPWRPPTNVRRTREDVRPIFWANRPKSYISRTTAWDQYPSGRWGDSR 357
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
+P+YGALTDYQF+R R+R+KK+ EEW VPL S+EDI
Sbjct: 358 SPAYGALTDYQFLRRRSRNKKIQEEWVVPLSSVEDI 393
>A9U4S7_PHYPA (tr|A9U4S7) Methylenetetrahydrofolate reductase OS=Physcomitrella
patens subsp. patens GN=PHYPADRAFT_228287 PE=3 SV=1
Length = 592
Score = 642 bits (1655), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 295/411 (71%), Positives = 344/411 (83%), Gaps = 5/411 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K+ VVFSFEFFPPKTE+GV+NLF+RMDRMV H P+FCDITWGAGGS
Sbjct: 1 MKVIDKINNGLAGG--NVVFSFEFFPPKTEEGVENLFDRMDRMVMHQPAFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+ VTL+IANKMQN++CVETM+HLTCTNM VE +D AL ++KSNG+QN+LALRGDPPHGQ
Sbjct: 59 TSAVTLDIANKMQNMICVETMMHLTCTNMLVETLDGALDSVKSNGIQNILALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFV EGGF+CA DLV+HIRAKYGDYFGITVAGYPEAHP+ IG DGVA+ EAYQ +L Y
Sbjct: 119 DKFVTIEGGFSCALDLVRHIRAKYGDYFGITVAGYPEAHPEVIGEDGVASEEAYQKDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAG ++I+TQLFYDTDIFLKFVNDC QIGI PIVPGIMPI NYKGF+RMT CK
Sbjct: 179 LKEKCDAGGEVIITQLFYDTDIFLKFVNDCRQIGIKVPIVPGIMPIQNYKGFLRMTTLCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TK+PAEIMAALEPIKDN+EAV+ YGIHLGTEMC+KILAH I+TLHLY+LN+EKS L IL
Sbjct: 239 TKVPAEIMAALEPIKDNDEAVRAYGIHLGTEMCKKILAHDIRTLHLYSLNLEKSVLGILQ 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ S++SR LPWR PTN R +EDVRPIFWANRP+SYISRT WD +P GRWGD+
Sbjct: 299 NLGLIDFSRVSRPLPWRPPTNSKRTKEDVRPIFWANRPRSYISRTTSWDDFPRGRWGDTA 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
NP+YG+ +D+QF R + R KKL +EWAVPL S ED V ++ +YC L
Sbjct: 359 NPAYGSFSDHQFTRKKTRSKKLQKEWAVPLNSSED---VNAIFAKYCQGTL 406
>A9RW65_PHYPA (tr|A9RW65) Methylenetetrahydrofolate reductase OS=Physcomitrella
patens subsp. patens GN=PHYPADRAFT_161370 PE=3 SV=1
Length = 594
Score = 640 bits (1650), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 291/411 (70%), Positives = 345/411 (83%), Gaps = 5/411 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K+ VVFSFEFFPPKTE+GV+NLF+RMDRMV H P+FCDITWGAGGS
Sbjct: 1 MKVIDKINNGLAGG--NVVFSFEFFPPKTEEGVENLFDRMDRMVRHQPAFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+ +TL+IANKMQN++CVETM+HLTCTNM VE +DNAL +KSNG+QN+LALRGDPPHGQ
Sbjct: 59 TSAITLDIANKMQNMICVETMMHLTCTNMLVETLDNALDNVKSNGIQNILALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFV +GGF+CA DLV+HI+ KYGDYFGITVAGYPEAHPD IG DG+A+ EAY+ +L Y
Sbjct: 119 DKFVTIDGGFSCALDLVRHIKDKYGDYFGITVAGYPEAHPDVIGEDGIASEEAYKKDLAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAG ++IVTQLFYDTDIFLKFVNDC QIGI P+VPGIMPI NYKGF+RMT CK
Sbjct: 179 LKEKCDAGGEVIVTQLFYDTDIFLKFVNDCRQIGIKAPVVPGIMPIQNYKGFLRMTSLCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TK+PAEIMA LEPIKDN+EAV+ YGIHLGTEMC+KILAH I+TLHLY+LN+EKS L IL
Sbjct: 239 TKVPAEIMATLEPIKDNDEAVRAYGIHLGTEMCKKILAHDIRTLHLYSLNLEKSVLGILQ 298
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLI+ SK++R LPWR PTN R +EDVRPIFWANRP+SYISRT WD++P GRWGD+G
Sbjct: 299 NLGLIDFSKVTRPLPWRPPTNSKRTKEDVRPIFWANRPRSYISRTTSWDEFPRGRWGDTG 358
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
NP+YG+ +D+QF+R + R KKL +EWAVPL S ED V ++ +YC L
Sbjct: 359 NPAYGSFSDHQFLRKKTRSKKLQKEWAVPLNSCED---VNQIFAKYCQGTL 406
>M1C550_SOLTU (tr|M1C550) Methylenetetrahydrofolate reductase OS=Solanum
tuberosum GN=PGSC0003DMG400023361 PE=3 SV=1
Length = 561
Score = 634 bits (1636), Expect = e-179, Method: Compositional matrix adjust.
Identities = 307/407 (75%), Positives = 338/407 (83%), Gaps = 41/407 (10%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ D RVVFSFEFFPPKTEDGVDNLFERM+RMV+HNPSFCDITWGAGGS
Sbjct: 1 MKVIEKIQESVKDD--RVVFSFEFFPPKTEDGVDNLFERMERMVSHNPSFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEI+N+MQN+VCVETM+HLTCTNMPVEKID+AL+TIKSNG+QNVLALRGDPPHGQ
Sbjct: 59 TADLTLEISNRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACA DLVKH+RAKYGDYFGITVAGYPEAHPD I + G+AT E Y+NEL Y
Sbjct: 119 DKFVQVEGGFACALDLVKHMRAKYGDYFGITVAGYPEAHPDVIPATGLATLETYENELAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTD FLKF
Sbjct: 179 LKQKVDAGADLIVTQLFYDTDNFLKF---------------------------------- 204
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
IPAEI AALEPIKDNEEAVK YGIHLGTEMC+KI+A GIKTLHLYTLNMEKSALAIL
Sbjct: 205 --IPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIMASGIKTLHLYTLNMEKSALAILM 262
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LGLIEESKISR LPWRRPTNVFR++EDVRPIFWANRPKSYISRTIGWD++PHGRWG++
Sbjct: 263 NLGLIEESKISRPLPWRRPTNVFRIKEDVRPIFWANRPKSYISRTIGWDEFPHGRWGNAK 322
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
NPSYGAL+DYQFMR R+RDKKL EEWA+ L S+EDIY ++ YC
Sbjct: 323 NPSYGALSDYQFMRARSRDKKLQEEWAIALNSVEDIYE---RFMNYC 366
>M4CKS5_BRARP (tr|M4CKS5) Methylenetetrahydrofolate reductase OS=Brassica rapa
subsp. pekinensis GN=Bra004810 PE=3 SV=1
Length = 556
Score = 620 bits (1599), Expect = e-175, Method: Compositional matrix adjust.
Identities = 289/374 (77%), Positives = 327/374 (87%), Gaps = 14/374 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K++ D + FSFEFFPPKTEDGVDNLFERMDRMVA+ P+FCDITWGAGGS
Sbjct: 1 MKVIDKIQSLA--DEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA++MQN+VCVE+M+HLTCTNMPVEKID+AL+TI++NG+QNVLALRGDPPHG
Sbjct: 59 TADLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRANGIQNVLALRGDPPHGH 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFV+ EGGF CA DLV H+R KY EAHPD IG +G+A+ EAYQ++L Y
Sbjct: 119 DKFVKVEGGFGCALDLVNHVRGKY------------EAHPDVIGENGLASDEAYQSDLEY 166
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLIVTQLFYDTD+FLKFVNDC QIGI CPIVPGIMPINNYKGF+RMTGFCK
Sbjct: 167 LKRKVDAGADLIVTQLFYDTDVFLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMTGFCK 226
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAE+MAALEPI+DNEEAVK YGIHLGTEMCRKILAHG K+LHLYTLNMEKSALAIL
Sbjct: 227 TKIPAEVMAALEPIQDNEEAVKAYGIHLGTEMCRKILAHGTKSLHLYTLNMEKSALAILM 286
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+LG+I+ESKISRSLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +P GRWGDS
Sbjct: 287 NLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWEDFPQGRWGDSR 346
Query: 361 NPSYGALTDYQFMR 374
+ SYGALTD+Q R
Sbjct: 347 SASYGALTDHQRFR 360
>C6T731_SOYBN (tr|C6T731) Methylenetetrahydrofolate reductase OS=Glycine max PE=1
SV=1
Length = 344
Score = 583 bits (1502), Expect = e-164, Method: Compositional matrix adjust.
Identities = 276/309 (89%), Positives = 291/309 (94%), Gaps = 1/309 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+ DP+RVVFSFEFFPPKTEDGVDNLFERMDRMV HNPSFCDITW AGG+
Sbjct: 1 MKIIEKIHAASA-DPNRVVFSFEFFPPKTEDGVDNLFERMDRMVVHNPSFCDITWSAGGT 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TLEIANKMQNIVCVETM+HLTCTNMPVEKID+AL TIKSNGLQNVLALRGDPPHGQ
Sbjct: 60 TADLTLEIANKMQNIVCVETMMHLTCTNMPVEKIDHALHTIKSNGLQNVLALRGDPPHGQ 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLV+HIRAKYGDYFGITVAGYPEAHPD I SDG+AT+E YQN+L Y
Sbjct: 120 DKFVQVEGGFACARDLVQHIRAKYGDYFGITVAGYPEAHPDVIESDGLATSEGYQNDLAY 179
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 180 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 239
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGI TLHLYTLNMEKSALAIL
Sbjct: 240 TKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLYTLNMEKSALAILM 299
Query: 301 SLGLIEESK 309
+LGLIEE+K
Sbjct: 300 NLGLIEETK 308
>I3S0L6_LOTJA (tr|I3S0L6) Methylenetetrahydrofolate reductase OS=Lotus japonicus
PE=2 SV=1
Length = 340
Score = 582 bits (1501), Expect = e-164, Method: Compositional matrix adjust.
Identities = 277/328 (84%), Positives = 298/328 (90%), Gaps = 4/328 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK+ DP++VVFSFEFFPPKTE GV NL ERMDRMVAH+PSFCDITWGAGGS
Sbjct: 1 MKVIEKIHEAAASDPNKVVFSFEFFPPKTEGGVVNLLERMDRMVAHSPSFCDITWGAGGS 60
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TADVTL+IA KMQN V VETM+HLTCTNMPVEKID+AL+TIKSNGLQNVLALRGDPPHGQ
Sbjct: 61 TADVTLDIAKKMQNTVGVETMMHLTCTNMPVEKIDDALETIKSNGLQNVLALRGDPPHGQ 120
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKFVQ EGGFACARDLVKHIRAK+GDYFGIT+AGYPEAHPDAIGS+G+AT E YQN+LTY
Sbjct: 121 DKFVQVEGGFACARDLVKHIRAKHGDYFGITIAGYPEAHPDAIGSNGLATPEDYQNDLTY 180
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LKSKVDAGADLI+TQLFYDTDIFLKF NDC QIGITCPIVPGIMPINNYKGFIRMTGFCK
Sbjct: 181 LKSKVDAGADLIITQLFYDTDIFLKFANDCRQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TKIPAEIMAALEPIKDNEEAVK YGIHLGTEMC+KILAHG KTLHLYTLN+EKSALAIL
Sbjct: 241 TKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGFKTLHLYTLNLEKSALAILK 300
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVRED 328
+LGLIEE+ S+P RP N + +ED
Sbjct: 301 NLGLIEET----SIPRTRPANAIQAKED 324
>M0YZ59_HORVD (tr|M0YZ59) Methylenetetrahydrofolate reductase OS=Hordeum vulgare
var. distichum PE=3 SV=1
Length = 287
Score = 506 bits (1304), Expect = e-141, Method: Compositional matrix adjust.
Identities = 243/290 (83%), Positives = 263/290 (90%), Gaps = 4/290 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVIEK++ R VFSFE+FPPKTE+GV+NLFERMDRMVAH P+FCDITWGAGGS
Sbjct: 1 MKVIEKIQEAAANG--RTVFSFEYFPPKTEEGVENLFERMDRMVAHGPNFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TADVTL+IAN+MQN+VCVETM+HLTCTNMPVEKIDNAL TIK+NG+QNVLALRGDPPHGQ
Sbjct: 59 TADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAI-GSDGVATTEAYQNELT 179
DKFVQ GGF+CA DLV+HIRAKYGDYFGITVAGYPEAHP+ I G DG AT EAY +L
Sbjct: 119 DKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDG-ATEEAYSKDLA 177
Query: 180 YLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGAD+IVTQLFYDTDIFLKFVNDC QIGITCPIVPGIMPINNYKGF+RMTGFC
Sbjct: 178 YLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFC 237
Query: 240 KTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTL 289
KTKIPAEI AAL+PIKDNEEAVK YGIHLGTEMC+KILA GIKTLHLYTL
Sbjct: 238 KTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTL 287
>D8U7H4_VOLCA (tr|D8U7H4) Methylenetetrahydrofolate reductase OS=Volvox carteri
GN=VOLCADRAFT_95450 PE=3 SV=1
Length = 595
Score = 505 bits (1300), Expect = e-140, Method: Compositional matrix adjust.
Identities = 239/411 (58%), Positives = 300/411 (72%), Gaps = 8/411 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I K+ + FSFEFFPP+TE+GV+NLFER+DRMVA+ P FCDITWGAGGS
Sbjct: 1 MKIINKINQKLKDG--QTFFSFEFFPPRTEEGVENLFERLDRMVAYGPIFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TADVTL+IA +MQN VCVETM+HLTCTNMPVEK+++AL +K G+ N+LALRGDPP GQ
Sbjct: 59 TADVTLDIATRMQNQVCVETMMHLTCTNMPVEKLESALLEVKKAGVHNILALRGDPPKGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
DKF EGGF+CA DLVK+IR ++GD FGI VAGYPEAHPD I D + Y ++ Y
Sbjct: 119 DKFEAVEGGFSCALDLVKYIRKEFGDLFGICVAGYPEAHPDGIVDDPELMEQNYWADIAY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV+AG +LI+TQLFY+TDIFLKFV DC +GIT PI+PGIMPI Y GF RMTGFCK
Sbjct: 179 LKQKVEAGGELIITQLFYNTDIFLKFVEDCRSVGITVPILPGIMPIMTYGGFKRMTGFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TK+PA+I+ A+E IKDN+EAVK +G+ LG MCR++L G+ +H+YTLN+E+SA+ IL
Sbjct: 239 TKVPADILEAVEAIKDNDEAVKNFGVDLGVRMCRRLLDAGVPGVHMYTLNLERSAVGILE 298
Query: 301 SLGLIEESKISRSLPWRR-PTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS 359
LGLI+ +++ + LPWR PT R E VRP+FW+NR K+Y+ RT GW YP GRW D
Sbjct: 299 RLGLIDTARVPKPLPWRHVPTGTARAAESVRPVFWSNRTKAYLKRTQGWPSYPTGRWADR 358
Query: 360 GNPSYGALTDY-QFMRPR----ARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
G YG+L D Q+MR AR ++ W L S +D+ V Y +
Sbjct: 359 GALQYGSLADVPQYMRRHTSTDARKERARAAWGSSLESEDDVKAVFAKYFK 409
>A8IAY6_CHLRE (tr|A8IAY6) Methylenetetrahydrofolate reductase OS=Chlamydomonas
reinhardtii GN=CHLREDRAFT_111330 PE=1 SV=1
Length = 594
Score = 492 bits (1267), Expect = e-136, Method: Compositional matrix adjust.
Identities = 239/417 (57%), Positives = 298/417 (71%), Gaps = 14/417 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I KV FSFEFFPP+TE+GV+NLFER+DRMVA+ P FCDITWGAGGS
Sbjct: 1 MKLIHKVEEKMKKG--ETFFSFEFFPPRTEEGVENLFERLDRMVAYGPVFCDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TADVTL+IA +MQN++CVETM+HLTCTNMP EK+++AL +K G+QN+LALRGDPP +
Sbjct: 59 TADVTLDIATRMQNLICVETMMHLTCTNMPEEKLESALHEVKKMGVQNILALRGDPPKVR 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
G C V +++GDYFGI VAGYPEAHPD I D + Y ++ Y
Sbjct: 119 ------VGACVCVTSAVHQDESQHGDYFGICVAGYPEAHPDGIVDDPEQMKKNYWADIAY 172
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG D+IVTQLFYD D+FL+FV DC +GITCPI+PGIMPI Y GF RMTGFCK
Sbjct: 173 LKQKVDAGGDMIVTQLFYDVDVFLQFVKDCRSVGITCPILPGIMPIMTYGGFKRMTGFCK 232
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAIL 299
TK+PAEI ALE IKDN+EAVK YGI LG MCR++LA G + +H+YTLN+EKSA+AIL
Sbjct: 233 TKVPAEISDALEAIKDNDEAVKAYGIDLGVRMCRQLLASGEVPGVHMYTLNLEKSAVAIL 292
Query: 300 TSLGLIEESKISRSLPWRR-PTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
LGL++ S++ R LPWR P R E VRP+FW+NRPK+Y+ RT WD YP GRWG+
Sbjct: 293 EQLGLVDTSRVQRPLPWRHVPAGTARAVEQVRPVFWSNRPKAYVKRTQDWDSYPAGRWGN 352
Query: 359 SGNPSYGALTDYQFMR----PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
+ +P+YGAL+D+QFMR AR +K W S++D+ V + Y++ S L
Sbjct: 353 TRSPAYGALSDHQFMRRHSTGEARREKARAAWGAAPASVDDVKQVFVKYIKGEVSLL 409
>G7IDE3_MEDTR (tr|G7IDE3) Methylenetetrahydrofolate reductase OS=Medicago
truncatula GN=MTR_1g039970 PE=1 SV=1
Length = 442
Score = 473 bits (1217), Expect = e-131, Method: Compositional matrix adjust.
Identities = 221/240 (92%), Positives = 232/240 (96%)
Query: 158 AHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITC 217
AHPD IG+DG+AT E YQ++L YLKSKVDAGADLIVTQLFYDTDIFLKFVNDC QIGITC
Sbjct: 6 AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 65
Query: 218 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKIL 277
PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVK YGIHLGTEMC+KI+
Sbjct: 66 PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 125
Query: 278 AHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANR 337
AHGIKT+HLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRV+EDVRPIFWANR
Sbjct: 126 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 185
Query: 338 PKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIY 397
PKSYISRTIGW+QYPHGRW DSGNPSYGALTDYQFMRPRA+DKKL EEWAVPL+SIEDIY
Sbjct: 186 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 245
>L8H1T6_ACACA (tr|L8H1T6) Methylenetetrahydrofolate reductase OS=Acanthamoeba
castellanii str. Neff GN=ACA1_267230 PE=3 SV=1
Length = 587
Score = 448 bits (1152), Expect = e-123, Method: Compositional matrix adjust.
Identities = 217/408 (53%), Positives = 283/408 (69%), Gaps = 16/408 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I+K+ + R +FSFE+FPPKT++GV NLFER+DRM + P + D+TWGAGGS
Sbjct: 1 MKIIDKINAAI--EEKRTMFSFEYFPPKTDEGVINLFERLDRMASFEPEWIDVTWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TA TLEI Q +ETM+HLTCTNMP +ID+AL+ K+ G+QN+LALRGDPP G+
Sbjct: 59 TAQKTLEICATAQKYCGLETMMHLTCTNMPRAEIDDALRQAKAAGIQNILALRGDPPRGE 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ + + EGGFA A DLV++IRA+YGD+FGI VAGYPE H D +E+ +L +
Sbjct: 119 E-WKKVEGGFAHAADLVRYIRAEYGDFFGICVAGYPEMHLD---------SESRDKDLEH 168
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+K+DAGAD I+TQLFYDT +FLKFVNDC +GI CPI+PG+MPI Y GF RMT CK
Sbjct: 169 LKAKIDAGADFIITQLFYDTSLFLKFVNDCRALGINCPIIPGMMPIQTYGGFRRMTSLCK 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T IP I ALEPI+D++ AVK YG+ L +MCR +LA G +H YTLN+EK+ IL
Sbjct: 229 TFIPEHINKALEPIQDDDSAVKKYGVDLCVQMCRDLLAAGTPGVHFYTLNLEKAVTQILE 288
Query: 301 SLGLIEESKISRSLPWRRPTNVFRV-REDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS 359
L LI S+ SR+LPWR R +EDVRPIFWANRP+SY+SRT WD +P+GRWGDS
Sbjct: 289 DLDLIAASRPSRALPWRSSAYTNRKEKEDVRPIFWANRPRSYMSRTASWDDFPNGRWGDS 348
Query: 360 GNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+P++G L D+ +++W V +EDI V ++ +C
Sbjct: 349 RSPAFGELKDWHLGSMAPPRSNYSKQWGVAPEKVEDIINV---FVGHC 393
>L1IVS6_GUITH (tr|L1IVS6) Methylenetetrahydrofolate reductase OS=Guillardia theta
CCMP2712 GN=GUITHDRAFT_96413 PE=3 SV=1
Length = 594
Score = 441 bits (1135), Expect = e-121, Method: Compositional matrix adjust.
Identities = 212/380 (55%), Positives = 276/380 (72%), Gaps = 6/380 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK++++++ +SFEFFPPKT GV NL+ER++R+ P F DITWGAGGS
Sbjct: 1 MKIVDRLKERNGAP----FYSFEFFPPKTPSGVSNLYERVERLGKLEPLFVDITWGAGGS 56
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+TLE+++ Q +ET +HLTCTN+ E + ALQ + G+QN+L LRGDPP GQ
Sbjct: 57 TSDLTLELSSNFQRQFNLETQMHLTCTNVTKETVTQALQQAREAGIQNILCLRGDPPAGQ 116
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+K+ TEGGFA A DLV+++R +GDYFGI+VAGYPE H D + E Y+ +L Y
Sbjct: 117 EKWEATEGGFANAVDLVRYVRQLHGDYFGISVAGYPEGHIDWFKDTPEISEEDYRRDLQY 176
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD+I+TQLFYD D+FLK+V DC +IGI PIVPGIMPIN Y GF RMTGFCK
Sbjct: 177 LKDKVDAGADMIITQLFYDVDVFLKWVKDCREIGINVPIVPGIMPINAYAGFNRMTGFCK 236
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TK+P I LE IKDNE+AVK YG+ L T+MCR++L +GI LH+YTLN+EKS +AIL
Sbjct: 237 TKVPKAIRDGLEAIKDNEDAVKEYGVQLVTDMCRRLLDNGIPGLHMYTLNLEKSTVAILN 296
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
+L L++ + R+LPWR + + EDVRPIFWANRP+SY SRT+ WD+YP+GRWGDS
Sbjct: 297 NLNLLKNTTSRRALPWR--PRIGQKTEDVRPIFWANRPRSYNSRTMHWDEYPNGRWGDSR 354
Query: 361 NPSYGALTDYQFMRPRARDK 380
+P++G LTDY + D+
Sbjct: 355 SPAFGELTDYHLTQVHTVDE 374
>M2XB69_GALSU (tr|M2XB69) Methylenetetrahydrofolate reductase OS=Galdieria
sulphuraria GN=Gasu_52550 PE=3 SV=1
Length = 625
Score = 429 bits (1104), Expect = e-118, Method: Compositional matrix adjust.
Identities = 207/409 (50%), Positives = 286/409 (69%), Gaps = 12/409 (2%)
Query: 2 KVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGST 61
KV EK++ D ++ FSFE+FPPKT GVDNL++R+DRM P F D+TWGAGGST
Sbjct: 14 KVHEKIKHRQ--DMGKIFFSFEYFPPKTPSGVDNLYDRIDRMSRVEPLFVDVTWGAGGST 71
Query: 62 ADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQD 121
+D+TLEI+ +Q ++ +HLTCTNMP K+D+AL K G++N++ALRGDPP G++
Sbjct: 72 SDLTLEISGNIQRYFGLDVCMHLTCTNMPSGKVDDALNAAKERGIRNIVALRGDPPKGEE 131
Query: 122 KFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYL 181
+ EGGF A DLV+HIR +G++F I VAGYPE HP + + Y+ EL +L
Sbjct: 132 -WHSIEGGFEHAVDLVRHIRKSFGEHFSICVAGYPEGHPAGL----LEGNLTYEQELHFL 186
Query: 182 KSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKT 241
K KV+AG + I+TQ+FYDTD FL+FV DC IGI PI+PGI+PI NY GF RMT FCKT
Sbjct: 187 KEKVEAGGNFIITQMFYDTDRFLQFVKDCRSIGIEVPIIPGILPIQNYNGFERMTKFCKT 246
Query: 242 KIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILT 300
+P E++ AL+PIKD++ AVK +GI LG +MCR+IL G + +H YTLN+EK+ ++I+
Sbjct: 247 HVPDEVLKALQPIKDDDAAVKEFGIRLGIDMCRRILHSGLVPGIHFYTLNLEKAVMSIIE 306
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L +I +++ RSLPWR T R EDVRPIFW+NRPKSYISRT GWD++P+GRWGD+
Sbjct: 307 GLDMIPKNQSIRSLPWRPATIDRRRHEDVRPIFWSNRPKSYISRTEGWDEFPNGRWGDNR 366
Query: 361 NPSYGALTDYQFMRP---RARDKKLTEEWAV-PLRSIEDIYVVGLLYLQ 405
+P++G LT++ + R++++K A L++ D+ + L YL
Sbjct: 367 SPAFGELTEHHLLGSGGFRSKEEKEALHRAYGELKNFSDVSNIFLRYLS 415
>R7Q356_CHOCR (tr|R7Q356) Methylenetetrahydrofolate reductase OS=Chondrus crispus
GN=CHC_T00008486001 PE=4 SV=1
Length = 631
Score = 429 bits (1102), Expect = e-117, Method: Compositional matrix adjust.
Identities = 201/358 (56%), Positives = 263/358 (73%), Gaps = 6/358 (1%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R FSFE+FPPKTE GV NL++R++RM A P FCD+TWGAGGST+D+TL ++ +Q +
Sbjct: 40 RPFFSFEYFPPKTEQGVSNLYQRVERMTAAEPLFCDVTWGAGGSTSDLTLSLSGNIQKYL 99
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
V+ M+HLTCTNMP + L+ K+ G++N+LALRGDPP G++ + + E GF DL
Sbjct: 100 GVDVMMHLTCTNMPSGNVLEGLEGAKALGIRNILALRGDPPAGKE-WTKCEDGFEHGTDL 158
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V+ IRA YGDYFGI VAGYPE HP DG + +++E+ +LK KVDAGAD I+TQ+
Sbjct: 159 VRFIRANYGDYFGICVAGYPEGHPAGF-LDGKMS---FEDEMKHLKDKVDAGADFIITQM 214
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D +LKFV C + GIT PI+PGI+PI NY GF RMTGFCKTK+P I+ A+E IKD
Sbjct: 215 FYDVDCYLKFVRSCREQGITIPILPGILPIQNYMGFKRMTGFCKTKVPQAILDAIEQIKD 274
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKT-LHLYTLNMEKSALAILTSLGLIEESKISRSLP 315
N+ AVK +G+ LG +MCR+IL G+ +H YTLN+EKSA+AI+ L LI +++ RSLP
Sbjct: 275 NDVAVKQFGVRLGVDMCRRILKSGLSPGIHFYTLNLEKSAMAIIDQLDLIPQTESIRSLP 334
Query: 316 WRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
WR T R E+VRPIFWANRPKSY+ RT WD+YP+GRWGD+ +P+YG L +Y +
Sbjct: 335 WRPATVDKRRNENVRPIFWANRPKSYLDRTSTWDEYPNGRWGDNRSPAYGDLREYHLL 392
>K3WKM9_PYTUL (tr|K3WKM9) Methylenetetrahydrofolate reductase OS=Pythium ultimum
GN=PYU1_G005510 PE=3 SV=1
Length = 590
Score = 428 bits (1100), Expect = e-117, Method: Compositional matrix adjust.
Identities = 198/405 (48%), Positives = 272/405 (67%), Gaps = 11/405 (2%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I+K+ + + V +SFEFFPPKT GVDNL+ RMDRM + P FCD+TWGAGGS
Sbjct: 1 MKIIDKINQCI--EKNEVFYSFEFFPPKTPAGVDNLYTRMDRMASLEPLFCDMTWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+A +T++I+ Q + +E ++H+TCTNM E + NAL+ K G+ N+LALRGDP G
Sbjct: 59 SAQLTIDISANAQKLSGLEMLMHMTCTNMAEEDVKNALEKAKDAGITNILALRGDPVRGA 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
F + + GF+ A DLV++I+ YGD+F I VAGYPE H +++ S ++ Y
Sbjct: 119 VSFNECDRGFSHAVDLVRYIKEHYGDHFSIGVAGYPERHAESVDS---------ATDIKY 169
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGAD ++TQLFYD ++++KFV DC ++GITCPI+PGIMPI NY GF+RMT FC
Sbjct: 170 LKEKIDAGADFVITQLFYDVNVYVKFVEDCRKVGITCPIIPGIMPIQNYGGFVRMTSFCS 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T +P EI ALEPIKDN+EAVK YG+ LG EMC++++A G LH YTLN+E+S IL
Sbjct: 230 TYVPEEITTALEPIKDNDEAVKDYGVELGIEMCKQLMAAGAPGLHFYTLNLERSVRRILD 289
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L + + R LPWR T R E VRPI+W+NRPKSYI RT WD+YP+GRWG+S
Sbjct: 290 GLSITSSNASRRELPWRPSTLSKRSSETVRPIYWSNRPKSYIQRTALWDEYPNGRWGNSE 349
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+P++G L++ + + W S +DI+ + Y++
Sbjct: 350 SPAFGDLSESHYFSTNVTPQNRKAMWGEAPVSKDDIHQTFVKYVR 394
>I1KG06_SOYBN (tr|I1KG06) Methylenetetrahydrofolate reductase OS=Glycine max PE=3
SV=1
Length = 473
Score = 427 bits (1099), Expect = e-117, Method: Compositional matrix adjust.
Identities = 206/241 (85%), Positives = 217/241 (90%), Gaps = 4/241 (1%)
Query: 163 IGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPG 222
I + TT A Q+ L +VDAGADLIVTQLFYDTDIFLKFVNDC QIGITCPIVPG
Sbjct: 44 ISELNMVTTLALQS----LVIQVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPG 99
Query: 223 IMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIK 282
IMPINNYKGFIRMTGFCKTKIPA+IMAALEPIKDNEEAVK YGIHLGTEMC+KILAHGI
Sbjct: 100 IMPINNYKGFIRMTGFCKTKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGIN 159
Query: 283 TLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYI 342
TLHLYTLNMEKSALAIL +LGLIEE+K+SRSLPWRRP NVFRV+EDVRPIFWANRPKSYI
Sbjct: 160 TLHLYTLNMEKSALAILMNLGLIEETKVSRSLPWRRPANVFRVKEDVRPIFWANRPKSYI 219
Query: 343 SRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLL 402
SRTIGWDQYPHGRWGDS NPSYGAL+DYQFMRPRARDKKL EEWAVPL+SIEDIY L
Sbjct: 220 SRTIGWDQYPHGRWGDSCNPSYGALSDYQFMRPRARDKKLVEEWAVPLKSIEDIYERFRL 279
Query: 403 Y 403
Y
Sbjct: 280 Y 280
>J7MPV6_9CHLO (tr|J7MPV6) Methylenetetrahydrofolate reductase OS=Polytomella sp.
Pringsheim 198.80 GN=mthfr PE=2 SV=1
Length = 629
Score = 427 bits (1097), Expect = e-117, Method: Compositional matrix adjust.
Identities = 201/331 (60%), Positives = 252/331 (76%), Gaps = 4/331 (1%)
Query: 29 TEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTN 88
TE+GV+NLFER +R+V++ P FCDITWGAGGSTADVT +IA KMQN+V VETM+HLTCTN
Sbjct: 27 TEEGVENLFERQERLVSYGPVFCDITWGAGGSTADVTQDIAVKMQNLVGVETMMHLTCTN 86
Query: 89 MPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYF 148
MP E+++ AL+ ++ G++N+LALRGD P GQDKF EGGF+CA DLVK+I+ ++G YF
Sbjct: 87 MPKERLEIALKEVQKAGVKNILALRGDAPKGQDKFEAIEGGFSCALDLVKYIKKEFGSYF 146
Query: 149 GITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVN 208
GI VAGYPEAHPD+I D + Y + YLK KVDAGAD I+TQLFYD +IF+KF+N
Sbjct: 147 GIGVAGYPEAHPDSIVDDPEQMKKNYFENIEYLKKKVDAGADFIITQLFYDANIFIKFMN 206
Query: 209 DCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHL 268
DC GITCPI+PGIMPI +Y GF RMT FCKT +P I+ A+E IKD+EEA+K +GI
Sbjct: 207 DCRAAGITCPILPGIMPIASYAGFKRMTSFCKTHVPQHILDAVEAIKDDEEAIKNFGISY 266
Query: 269 GTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISR-SLPWRRPTNVF--RV 325
G EMCRK+LA G +HLYTLN+E+SA+ I+ LG++ E SR LPW RP ++ R
Sbjct: 267 GVEMCRKVLAAGAPGVHLYTLNLERSAVGIVEKLGIMPEQLGSRFPLPW-RPASIGTDRT 325
Query: 326 REDVRPIFWANRPKSYISRTIGWDQYPHGRW 356
E VRPIFWANRPKSY+ RT W ++P W
Sbjct: 326 NEGVRPIFWANRPKSYVLRTSHWTEFPSKSW 356
>F0ZME6_DICPU (tr|F0ZME6) Methylenetetrahydrofolate reductase OS=Dictyostelium
purpureum GN=DICPUDRAFT_34262 PE=3 SV=1
Length = 606
Score = 427 bits (1097), Expect = e-117, Method: Compositional matrix adjust.
Identities = 199/372 (53%), Positives = 267/372 (71%), Gaps = 12/372 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I+K+ + + +SFE+FPPKT +GV NL++R+ RM+ P F DITWGAGGS
Sbjct: 4 MKIIDKINQKK--ESNVPFYSFEYFPPKTMEGVQNLYDRLGRMLLFEPLFIDITWGAGGS 61
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+ +TLEIA K QN+ +ETM+HLTCTNMPV +I AL K+ G++N+LALRGDPP G+
Sbjct: 62 TSALTLEIAEKAQNVCGLETMMHLTCTNMPVNEIIYALDKAKATGIRNILALRGDPPRGE 121
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ + + EGGF A DLVK IR +YGDYFGI VAGYPE H D ++++++T+
Sbjct: 122 E-WKKIEGGFGYACDLVKFIRERYGDYFGICVAGYPEGHSDCT---------SFEDDITH 171
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+KVDAGADLI+TQLFYD D+F FV C ++GI CPI+PGIMPI Y GF+RMT K
Sbjct: 172 LKAKVDAGADLIITQLFYDVDVFCDFVKKCREVGINCPIIPGIMPIQTYAGFVRMTTLSK 231
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
TK+P IM LEPIKDN+E VK YG+ L EM +++L G++ LH YTLN+E+S +L
Sbjct: 232 TKVPQYIMDNLEPIKDNDEEVKKYGVRLCVEMSKRLLEFGVEGLHFYTLNLERSVRKVLK 291
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L L+ ++S LPW + R++E+VRPIFW NRP+SYI+RT WD++P+GRWGD
Sbjct: 292 GLELVTPDQLSPYLPWAQSAAGNRLKEEVRPIFWQNRPRSYIARTGSWDEFPNGRWGDYR 351
Query: 361 NPSYGALTDYQF 372
+P++G L+DY
Sbjct: 352 SPAFGDLSDYHL 363
>D3BTZ2_POLPA (tr|D3BTZ2) Methylenetetrahydrofolate reductase OS=Polysphondylium
pallidum GN=PPL_11252 PE=3 SV=1
Length = 608
Score = 426 bits (1094), Expect = e-116, Method: Compositional matrix adjust.
Identities = 208/418 (49%), Positives = 286/418 (68%), Gaps = 22/418 (5%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I+K+ + + +SFE+FPPKT +GV NL++R+ RM+ P F DITWGAGGS
Sbjct: 8 MKIIDKINEYKSKN--QRFYSFEYFPPKTMEGVQNLYDRLGRMLLLEPLFVDITWGAGGS 65
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+ +TLEIA QNI +ETM+HLTCTNM VE+ID AL+ K++G++N+LALRGDPP G+
Sbjct: 66 TSQLTLEIAETSQNICGLETMMHLTCTNMKVEEIDFALEKAKASGVRNILALRGDPPRGE 125
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ + + EGGF A DLV++IR K+GD+FGI VAGYPE H D +++L +
Sbjct: 126 E-WKKIEGGFGYASDLVRYIRQKHGDHFGIAVAGYPEGHSDCTSK---------EDDLQH 175
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+K+DAGADLI+TQLFYD D+F FV C IGI CPI+PGIMPI+ Y GF RMT +
Sbjct: 176 LKNKIDAGADLIITQLFYDVDMFNDFVGKCRAIGINCPIIPGIMPIHTYAGFKRMTTLSQ 235
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T +P I+ ALEPIKDN+E VK YG+ L +MC +++ G+ LH YTLN+E+S +L
Sbjct: 236 TAVPPHILEALEPIKDNDEEVKKYGVKLCVQMCERLVEAGVDGLHFYTLNLERSVRKVLK 295
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L ++ +++R LPW + + R++E+VRPIFW +RP+SYISRT WD++P+GRWGD
Sbjct: 296 GLNMVRPDQLARYLPWAQCASTNRLKEEVRPIFWQHRPRSYISRTGSWDEFPNGRWGDYR 355
Query: 361 NPSYGALTDY-----QFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFLDK 413
+P++G L+DY QF +A K + A PL S +D+Y + YC L K
Sbjct: 356 SPAFGDLSDYHLSSLQFNSAQAEQNK-DDFGAAPL-STQDVYD---RFADYCAGRLKK 408
>F4PLP1_DICFS (tr|F4PLP1) Methylenetetrahydrofolate reductase OS=Dictyostelium
fasciculatum (strain SH3) GN=DFA_05596 PE=3 SV=1
Length = 595
Score = 425 bits (1092), Expect = e-116, Method: Compositional matrix adjust.
Identities = 205/390 (52%), Positives = 276/390 (70%), Gaps = 16/390 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
+SFE+FPPKT +GV NL++R+ RM+ P F DITWGAGGST+++TLEIA+ QNI +E
Sbjct: 21 YSFEYFPPKTMEGVQNLYDRLGRMLLLEPLFVDITWGAGGSTSELTLEIADTAQNICGLE 80
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
TM+HLTCTNM V +ID AL K +G++N+LALRGDPP G++ + + EGGFA A DLV++
Sbjct: 81 TMMHLTCTNMQVSQIDFALAKAKESGVRNILALRGDPPRGEE-WKKIEGGFAHASDLVRY 139
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGDYFGI VAGYPE H DA + +++L +LK+KVD GADLI+TQLFYD
Sbjct: 140 IRQHYGDYFGIAVAGYPEGHSDAT---------SLEDDLQHLKTKVDMGADLIITQLFYD 190
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D+F++FV C IGI PI+PGIMPI+ Y GF RMT KT +P I+ ALEPIKDN+E
Sbjct: 191 VDMFVEFVGKCRAIGINVPIIPGIMPIHTYAGFKRMTTLSKTVVPQHILDALEPIKDNDE 250
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRP 319
VK YG++L EMC++++A G+ LH YTLN+E+S +L L +I ++ R LPW +
Sbjct: 251 EVKKYGVNLCIEMCKQMVAAGVDGLHFYTLNLERSVRKVLKGLEMIRPDQLHRYLPWAQC 310
Query: 320 TNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARD 379
+ R++E+VRPIFW NRP+SYISRT WD++P+GRWGD +P++G L+DY + D
Sbjct: 311 ASTNRLKEEVRPIFWKNRPRSYISRTGSWDEFPNGRWGDYRSPAFGDLSDYH-LSSHQFD 369
Query: 380 KKLTEEWAV--PLRSIEDIYVVGLLYLQYC 407
T V ++S +D+Y V + YC
Sbjct: 370 PNATSATNVYGDVQSRQDVYEV---FANYC 396
>D2V2R1_NAEGR (tr|D2V2R1) Methylenetetrahydrofolate reductase OS=Naegleria
gruberi GN=NAEGRDRAFT_35291 PE=3 SV=1
Length = 594
Score = 421 bits (1082), Expect = e-115, Method: Compositional matrix adjust.
Identities = 209/417 (50%), Positives = 273/417 (65%), Gaps = 20/417 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I+K+ + ++ +SFE+FPPKT+ GV+NL++R+ RM P F DITWGAGGS
Sbjct: 1 MKIIDKINQCI--EENKTFYSFEYFPPKTDAGVENLYQRLQRMAKLAPMFIDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TA T+EI QN++ VET IH+TCTNM VE++D A+QT K G+ N+LALRGDPP G
Sbjct: 59 TAGKTIEIGATAQNMIGVETQIHMTCTNMKVEELDKAIQTAKDMGISNILALRGDPPLGS 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ + QT+GGF ARDL+ HIR +GDYFGI+ AGY E HP+ YQ +L Y
Sbjct: 119 EDWEQTDGGFKYARDLISHIRKTHGDYFGISCAGYSEGHPEG----------DYQKDLMY 168
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAGAD +VTQLFYD FLKFV + +IGI CPI+PGIMPINN+ + RMT FCK
Sbjct: 169 LKEKYDAGADFVVTQLFYDWQQFLKFVKEAREIGIKCPIIPGIMPINNHASWQRMTTFCK 228
Query: 241 TKIPAEI---MAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALA 297
T IP + MA L DNE VK YGI L +CR ++ +GI+ LH YTLN+EKS A
Sbjct: 229 TSIPQNVHDEMAKLNLEDDNE--VKAYGIKLCITICRALMDNGIRGLHFYTLNLEKSTEA 286
Query: 298 ILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWG 357
IL L L + I RSLPW +P N R+ E+VRPIFW+NR KSYI RT WD++P+GRW
Sbjct: 287 ILEGLELSPKESIPRSLPWVKPANAKRLAEEVRPIFWSNRVKSYIDRTQHWDEFPNGRWS 346
Query: 358 DSGNPSYGALTD---YQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
DS +P++G L + Y + R + + W ++E I V + +++ FL
Sbjct: 347 DSRSPAFGELGEEIAYFYRRKFGEKENIVAAWGAEHANLESISQVFVNFIEGKIPFL 403
>Q54X84_DICDI (tr|Q54X84) Methylenetetrahydrofolate reductase OS=Dictyostelium
discoideum GN=DDB_G0279137 PE=3 SV=1
Length = 627
Score = 420 bits (1080), Expect = e-115, Method: Compositional matrix adjust.
Identities = 196/353 (55%), Positives = 254/353 (71%), Gaps = 10/353 (2%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
+SFE+FPPKT +GV NL++R+ RM+ P F DITWGAGGST+ +TLEIA K QN+ +E
Sbjct: 21 YSFEYFPPKTMEGVQNLYDRLGRMLLFEPLFIDITWGAGGSTSALTLEIAEKAQNVCGLE 80
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
TM+HLTCTNMPV +I AL KS G++N+LALRGDPP G++ + + EGGFA A DLV+
Sbjct: 81 TMMHLTCTNMPVSEIIYALDKAKSTGIRNILALRGDPPRGEE-WKKIEGGFAYAADLVRF 139
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYGDYF I+VAGYPE H D + + ++ YLK KVDAGAD I+TQLFYD
Sbjct: 140 IREKYGDYFCISVAGYPEGHSDCVSK---------EEDIRYLKEKVDAGADFIITQLFYD 190
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
DIF +FV C +GI CPI+PGIMPI Y GF+RMT KTK+P IM LEPIKDN+E
Sbjct: 191 CDIFCEFVEKCRSVGINCPIIPGIMPIQTYAGFVRMTTLSKTKVPQYIMDNLEPIKDNDE 250
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRP 319
VK YG+ L EM +++L G++ LH YTLN+E+S +L L L+ ++S LPW +
Sbjct: 251 EVKKYGVRLCVEMSKRLLDFGVEGLHFYTLNLERSVRKVLKGLQLVTPDQLSPFLPWAQS 310
Query: 320 TNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQF 372
R++E+VRPIFW NRP+SYI+RT WD++P+GRWGD +P++G L+DY
Sbjct: 311 AAGNRLKEEVRPIFWQNRPRSYIARTGSWDEFPNGRWGDYRSPAFGDLSDYHL 363
>I0YN51_9CHLO (tr|I0YN51) Methylenetetrahydrofolate reductase OS=Coccomyxa
subellipsoidea C-169 GN=COCSUDRAFT_30887 PE=3 SV=1
Length = 342
Score = 418 bits (1074), Expect = e-114, Method: Compositional matrix adjust.
Identities = 193/314 (61%), Positives = 245/314 (78%), Gaps = 2/314 (0%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+++K+ + FSFEFFPP+T++GV+NL+ R RM A+ P+FCDITWGAGG+
Sbjct: 1 MKIVDKMNESIKAG--KTFFSFEFFPPRTDEGVENLYSRQHRMAAYGPTFCDITWGAGGT 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TAD+TL+IA KMQN V VETM+HLTCTNMP +++NAL +KS G+QN+LALRGDPP GQ
Sbjct: 59 TADLTLDIAAKMQNTVGVETMMHLTCTNMPESQLENALDKVKSYGIQNILALRGDPPKGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ F EGGF+CA DLVK+I+AKYGD+FGITVAGYPE HPDAI S+ +AY +L Y
Sbjct: 119 ETFTVVEGGFSCALDLVKYIKAKYGDFFGITVAGYPEGHPDAIVSNPEEMDKAYWADLHY 178
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG ++IVTQLFYD D F KFV D +GITCPI+PGIMPI Y GF RMT FCK
Sbjct: 179 LKEKIDAGGEIIVTQLFYDVDRFFKFVQDVRSLGITCPIIPGIMPIMTYGGFKRMTSFCK 238
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T IP+EI LE IKDN+EAVK YGI LGT+MCR++L G LH+YTLN+E ++++IL
Sbjct: 239 TAIPSEISEHLEKIKDNDEAVKAYGIELGTQMCRRLLEAGTPGLHMYTLNLENASVSILQ 298
Query: 301 SLGLIEESKISRSL 314
+LGLIE+S++S ++
Sbjct: 299 NLGLIEKSQVSATV 312
>D8S976_SELML (tr|D8S976) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_177964 PE=3 SV=1
Length = 322
Score = 405 bits (1040), Expect = e-110, Method: Compositional matrix adjust.
Identities = 192/316 (60%), Positives = 245/316 (77%), Gaps = 5/316 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I++V+ D ++V+SFEF PP+T G+ L + +DR+V PSFCDITW A S
Sbjct: 1 MKIIDRVKEAWSED--KIVYSFEFMPPRTPKGMKLLLDSLDRIVMFQPSFCDITWRA--S 56
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
++++TLEIA KM+ + +ETM+HLTC E+ID+AL ++S+G++N+LALRGDPP G+
Sbjct: 57 SSEMTLEIARKMKTMFGLETMMHLTCVGSTPERIDSALDFVRSHGVENILALRGDPPEGE 116
Query: 121 DKF-VQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELT 179
+ V G +CA DLV HIR YG FGI VAGYPEAHPD I +DG AT E YQ +L
Sbjct: 117 EALDVAGSGDLSCALDLVSHIRETYGSSFGIVVAGYPEAHPDVIQADGSATEEDYQKDLA 176
Query: 180 YLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGADLI++QLFYDTDIFLKFVNDC QIGITCPIVPGI+PIN+Y+ F+RMT C
Sbjct: 177 YLKKKVDAGADLIISQLFYDTDIFLKFVNDCRQIGITCPIVPGILPINDYRKFLRMTTLC 236
Query: 240 KTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAIL 299
KTK+PA++ AL+ IKD+ AV+ YGIHLGTEMC+KILAHGIK LHLYTLN EK+A+ IL
Sbjct: 237 KTKVPADVRDALQSIKDDPVAVRKYGIHLGTEMCKKILAHGIKALHLYTLNSEKTAIEIL 296
Query: 300 TSLGLIEESKISRSLP 315
+LGL++ SK++R LP
Sbjct: 297 KNLGLVDVSKVARPLP 312
>D0N474_PHYIT (tr|D0N474) Methylenetetrahydrofolate reductase OS=Phytophthora
infestans (strain T30-4) GN=PITG_05377 PE=3 SV=1
Length = 591
Score = 405 bits (1040), Expect = e-110, Method: Compositional matrix adjust.
Identities = 191/372 (51%), Positives = 250/372 (67%), Gaps = 11/372 (2%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K+ + V +SFEFFPPKT GVDNL+ RMDRM A P FCD+TWGAGGS
Sbjct: 1 MKVIDKINASL--ERQEVFYSFEFFPPKTPAGVDNLYARMDRMAALEPLFCDMTWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+A +TLE++ Q + +E ++H+TCTNM I AL K G+QN+LALRGDP G
Sbjct: 59 SAQLTLELSANAQKLSGLEMLMHMTCTNMADADIKKALDQAKDAGIQNILALRGDPVRGA 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
F + + GF+ A DLV++IR KYG++F I VAGYPE H + + + ++ Y
Sbjct: 119 TSFDECDRGFSHAVDLVRYIREKYGNHFCIGVAGYPEGHTE---------FKDKKADIQY 169
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD ++TQLFYD +F+ FV +C +GIT PI+PGIMPI NY GF RMT FC
Sbjct: 170 LKEKVDAGADFVITQLFYDVKVFVDFVKECRAVGITVPIIPGIMPIQNYGGFERMTSFCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T +P E+ ALEPIKDN+EAVK YG+ LG M ++++ G+ LH YTLN+E+S IL
Sbjct: 230 THVPDEVRKALEPIKDNDEAVKDYGVQLGITMSQQLIDAGVPGLHFYTLNLERSVRRILE 289
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L + R LPW+ T R E VRPI+W+NRPKSY+ RT WD+YP+GRWG+S
Sbjct: 290 GLSSLSSRVPRRELPWQTSTLSKRASESVRPIYWSNRPKSYVHRTAMWDEYPNGRWGNSE 349
Query: 361 NPSYGALTDYQF 372
+P++G LT+ F
Sbjct: 350 SPAFGELTESHF 361
>M1UY35_CYAME (tr|M1UY35) Methylenetetrahydrofolate reductase OS=Cyanidioschyzon
merolae strain 10D GN=CYME_CMT610C PE=3 SV=1
Length = 635
Score = 404 bits (1038), Expect = e-110, Method: Compositional matrix adjust.
Identities = 191/355 (53%), Positives = 253/355 (71%), Gaps = 6/355 (1%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
+SFEFFPPKTE G+ L+ER+ R+ P F D+TWGAGGST+D+TLE++ +Q ++
Sbjct: 48 YSFEFFPPKTEQGLLGLYERIARLSRLEPLFVDVTWGAGGSTSDLTLELSGNIQKFFGLD 107
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
+HLTCTNM +D AL+ + G++N+++LRGDPP GQ+ + Q + GFA A DLV+H
Sbjct: 108 VAMHLTCTNMEEGMVDKALEEARKRGIRNIVSLRGDPPVGQE-WRQCKDGFAHASDLVRH 166
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
+R YGDYF + VAGYPE HP + DG T Y+ EL YLK KVDAG DLI+TQ+FYD
Sbjct: 167 VRKVYGDYFCLIVAGYPEGHPAGL-LDGKLT---YEQELNYLKEKVDAGGDLIITQMFYD 222
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL+FV DC IGI PI+PGI+PI +Y GF RMTGFC+T +P + +E +KD+EE
Sbjct: 223 VDQFLRFVRDCRSIGIQVPILPGILPIQSYSGFKRMTGFCRTHVPEAVAETVERLKDDEE 282
Query: 260 AVKLYGIHLGTEMCRKILAHGIKT-LHLYTLNMEKSALAILTSLGLIEESKISRSLPWRR 318
AVK +GI GTEMCR+IL + LH YTLN+EK+ ++IL +LGL+ + + R+LPWR
Sbjct: 283 AVKNFGIEYGTEMCRRILNSKLSLGLHFYTLNLEKATVSILENLGLVPKFESVRALPWRP 342
Query: 319 PTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
T R EDVRPIFWANRP SY+ RT WD +P+GRWGDS +P+YG L ++ +
Sbjct: 343 ATIDGRRSEDVRPIFWANRPASYLLRTETWDDFPNGRWGDSRSPAYGELREHHLL 397
>G4YYD3_PHYSP (tr|G4YYD3) Methylenetetrahydrofolate reductase OS=Phytophthora
sojae (strain P6497) GN=PHYSODRAFT_541479 PE=3 SV=1
Length = 591
Score = 402 bits (1034), Expect = e-109, Method: Compositional matrix adjust.
Identities = 193/372 (51%), Positives = 250/372 (67%), Gaps = 11/372 (2%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+IEK+ + V +SFEFFPPKT GVDNL+ RMDRM A P FCD+TWGAGGS
Sbjct: 1 MKIIEKINASV--ERQEVFYSFEFFPPKTPAGVDNLYARMDRMAALEPLFCDMTWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+A +TLE++ Q + +E ++H+TCTNM I AL K G+ N+LALRGDP G
Sbjct: 59 SAQLTLELSANAQKLSGLEMLMHMTCTNMAEADIKKALDQAKDAGIHNILALRGDPVRGA 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
F + + GF+ A DLV+++R YGD+F I VAGYPE H ++ SD A ++ Y
Sbjct: 119 TSFDECDRGFSHAVDLVRYMREHYGDHFCIGVAGYPEGHMES--SDKKA-------DIQY 169
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I+TQLFYD +F+ FV +C +GIT PI+PGIMPI NY GF RMT FC
Sbjct: 170 LKEKVDAGADFIITQLFYDVQVFVDFVKECRAVGITVPIIPGIMPIQNYGGFERMTSFCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T +P E+ ALEPIKDN+EAVK YG+ LG M ++++ G+ LH YTLN+E+S IL
Sbjct: 230 TFVPEEVRKALEPIKDNDEAVKDYGVQLGITMSQQLIDAGVPGLHFYTLNLERSVRRILE 289
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L + R LPW+ T R E VRPI+W+NRPKSY+ RT WD+YP+GRWG+S
Sbjct: 290 GLLSLSSRVPRRELPWQTSTLSKRAAETVRPIYWSNRPKSYVHRTAMWDEYPNGRWGNSE 349
Query: 361 NPSYGALTDYQF 372
+P++G LT+ F
Sbjct: 350 SPAFGELTESHF 361
>H3GAC2_PHYRM (tr|H3GAC2) Methylenetetrahydrofolate reductase OS=Phytophthora
ramorum PE=3 SV=1
Length = 591
Score = 402 bits (1032), Expect = e-109, Method: Compositional matrix adjust.
Identities = 198/410 (48%), Positives = 261/410 (63%), Gaps = 20/410 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I+K+ + +SFEFFPPKT GVDNL+ RMDRM A P FCD+TWGAGGS
Sbjct: 1 MKIIDKINASV--ERQECFYSFEFFPPKTPAGVDNLYARMDRMAALEPLFCDMTWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+A +TLE++ Q + +E ++H+TCTNM I AL K G+QNVLALRGDP G
Sbjct: 59 SAQLTLELSANAQKLSGLEMLMHMTCTNMAEADIKKALDQAKDAGIQNVLALRGDPVRGA 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
F + + GF+ A DLV+ +R YGD+F I VAGYPE H + ++ + ++ Y
Sbjct: 119 SSFDECDRGFSHAVDLVRFMRETYGDHFCIGVAGYPEGHTE---------SQDKKLDIQY 169
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I+TQLFYD +F+ FV +C +GIT PI+PGIMPI NY GF RMT FC
Sbjct: 170 LKEKVDAGADFIITQLFYDVKVFVDFVKECRAVGITVPIIPGIMPIQNYGGFERMTSFCN 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T +P ++ ALEPIKDN+EAVK YG+ LG M ++++ G+ LH YTLN+E+S IL
Sbjct: 230 TFVPEDVRKALEPIKDNDEAVKDYGVQLGITMSQQLIDAGVPGLHFYTLNLERSVRRILE 289
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L + R LPW+ T R E VRPI+W+NRPKSY++RT WD+YP+GRWG+S
Sbjct: 290 GLSSLSSRVPRRELPWQTSTLSKRSAESVRPIYWSNRPKSYVNRTAMWDEYPNGRWGNSE 349
Query: 361 NPSYGALTDYQFM-----RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+P++G LT+ F P R K W S EDI + Y++
Sbjct: 350 SPAFGELTESHFAPTNTSTPSERRAK----WGEAPASKEDIRRTFVQYVR 395
>D8SVM0_SELML (tr|D8SVM0) Methylenetetrahydrofolate reductase OS=Selaginella
moellendorffii GN=SELMODRAFT_126029 PE=3 SV=1
Length = 322
Score = 401 bits (1030), Expect = e-109, Method: Compositional matrix adjust.
Identities = 190/316 (60%), Positives = 244/316 (77%), Gaps = 5/316 (1%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+I++V+ D ++V+SFEF PP+T G+ L + +DR+V PSFCDITW A S
Sbjct: 1 MKIIDRVKEAWSED--KIVYSFEFMPPRTPKGMKLLLDSLDRIVMFQPSFCDITWRA--S 56
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
++++TLEIA KM+ + +ETM+HLTC E+ID+AL ++S+G++N+LALRGDPP G+
Sbjct: 57 SSEMTLEIARKMKTMFGLETMMHLTCVGSTPERIDSALDFVRSHGVENILALRGDPPEGE 116
Query: 121 DKF-VQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELT 179
+ V +CA DLV HIR YG FGI VAGYPEAHPD I +DG AT E YQ +L
Sbjct: 117 EALDVAGSDDLSCALDLVSHIRETYGSSFGIVVAGYPEAHPDVIQADGSATEEDYQKDLA 176
Query: 180 YLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGADLI++QLFYDTDIFLKFVNDC QIGITCPIVPGI+PIN+Y+ F+RMT C
Sbjct: 177 YLKKKVDAGADLIISQLFYDTDIFLKFVNDCRQIGITCPIVPGILPINDYRKFLRMTTLC 236
Query: 240 KTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAIL 299
+TK+PA++ AL+ IKD+ AV+ YGIHLGTEMC+KILAHGIK LHLYTLN EK+A+ IL
Sbjct: 237 RTKVPADVRDALQSIKDDPVAVRKYGIHLGTEMCKKILAHGIKALHLYTLNSEKTAIEIL 296
Query: 300 TSLGLIEESKISRSLP 315
+LGL++ SK++R LP
Sbjct: 297 KNLGLVDVSKVARPLP 312
>F0W2Q3_9STRA (tr|F0W2Q3) Methylenetetrahydrofolate reductase OS=Albugo laibachii
Nc14 GN=AlNc14C10G1291 PE=3 SV=1
Length = 589
Score = 394 bits (1013), Expect = e-107, Method: Compositional matrix adjust.
Identities = 191/405 (47%), Positives = 261/405 (64%), Gaps = 13/405 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
M+ I+K+ +V FSFEFFPPKT GV NL++R+DR+ P FCD+TWGAGGS
Sbjct: 1 MRAIDKI--TDCISKKQVFFSFEFFPPKTAAGVQNLYKRIDRLGQLGPLFCDVTWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+EI++ Q + ++ ++HLTC N+ E AL ++ G+QN+L LRGDP G
Sbjct: 59 NHGSTIEISSNAQKM-GMDILMHLTCVNLTPENAITALDAARNAGIQNILVLRGDPVQGA 117
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
F + + GF+ A DL++ IR KY D F I VA +PE H A Q EL Y
Sbjct: 118 SSFEECDKGFSHAIDLIRFIRKKYKDAFCIGVAAHPEGHLHAADK---------QQELVY 168
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGA I+TQLFYD ++ +FV +C QIGITCPI+PG+MPI Y GF+RMT FC+
Sbjct: 169 LKEKVDAGAGFIITQLFYDVFVYKEFVCECRQIGITCPIIPGVMPIQTYGGFVRMTSFCE 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
++P EI ALEPIK N+EAVK YGI LG +MCRK+L G LH YTLN+E++ AIL+
Sbjct: 229 ARVPGEIQDALEPIKGNDEAVKEYGIRLGVKMCRKLLEDGAPGLHFYTLNLERAVRAILS 288
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L L+ + I R LPW + R E +RPI+W+NRP+SY++RT WD+YP+GRWG+S
Sbjct: 289 ELNLVNVNSI-RELPWHSTCCIKRAGESIRPIYWSNRPESYVARTALWDEYPNGRWGNSE 347
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+P++G L+D ++ + + E W L+S DI + Y++
Sbjct: 348 SPAFGELSDSPYVTTKLSASERREMWGHALKSTNDITKTFVSYVR 392
>F4P4P0_BATDJ (tr|F4P4P0) Methylenetetrahydrofolate reductase OS=Batrachochytrium
dendrobatidis (strain JAM81 / FGSC 10211)
GN=BATDEDRAFT_16794 PE=3 SV=1
Length = 592
Score = 385 bits (988), Expect = e-104, Method: Compositional matrix adjust.
Identities = 199/407 (48%), Positives = 259/407 (63%), Gaps = 16/407 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV++K++ D R +SFE+FPPKTE GV NLF+RM+RM P F D+TWGAGG+
Sbjct: 1 MKVVDKIQKAN--DEGRCFWSFEYFPPKTESGVVNLFDRMERMYLLGPEFIDVTWGAGGT 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+TLEI Q + +ET +HLTCTNMP KID AL+ K+ G+ N+LALRGD P GQ
Sbjct: 59 TSDLTLEICTTAQAVFGLETCMHLTCTNMPRIKIDEALEQAKNAGIMNILALRGDAPRGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ + E GF+ A DLV++IR KYGDYF I VAGYPE H + T + +L Y
Sbjct: 119 TNWTKVETGFSYATDLVRYIREKYGDYFCIGVAGYPEGHTE---------TPDKEADLLY 169
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV AGAD IVTQLFYD DI++ + + IT PI+PG++PI NY GF RMT K
Sbjct: 170 LKEKVLAGADYIVTQLFYDVDIYIDWSKKVRAMDITIPILPGLLPIQNYSGFKRMTALSK 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
T +P I+ LEPIKD+++AVK YGI L +MC K+ G + H Y LN+E+S IL
Sbjct: 230 TFVPQFILDDLEPIKDDDQAVKDYGIRLAVQMCNKMREAGQRGFHFYCLNLERSTRLILE 289
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L + + + LPW R +E VRPIFW NR KSYI RT GWD++P+GRWGDS
Sbjct: 290 GLDFVAPRENVKPLPWNPSLGKNREKETVRPIFWRNRTKSYIMRTDGWDEFPNGRWGDSR 349
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+P+YG + Y + + LT W P ++ DIY L+ +YC
Sbjct: 350 SPAYGDIDGYGIRLKYSAEDCLT-FWNHP-ETLGDIYG---LFEKYC 391
>I1BPZ7_RHIO9 (tr|I1BPZ7) Methylenetetrahydrofolate reductase OS=Rhizopus delemar
(strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
43880) GN=RO3G_02981 PE=3 SV=1
Length = 598
Score = 377 bits (969), Expect = e-102, Method: Compositional matrix adjust.
Identities = 189/407 (46%), Positives = 259/407 (63%), Gaps = 16/407 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKVI+K++ R +SFE+FPPKT GV NL++RM+RM + P F D+TWGAGG+
Sbjct: 1 MKVIDKIKRAEQEG--RSFWSFEYFPPKTPQGVQNLYDRMERMQRYGPEFVDVTWGAGGT 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+AD+T EI Q++ +ETM+HLTCTNMPV++ID+AL+ K G QN+LALRGDPP GQ
Sbjct: 59 SADLTTEIVATAQSVYGLETMMHLTCTNMPVQQIDDALEAAKKCGCQNILALRGDPPKGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ E GF A DLV++IR KYGDYF I VAG+PE H D +++L
Sbjct: 119 ANWESCESGFEHAVDLVRYIRQKYGDYFCIAVAGHPEGHID---------NPDKEDDLLR 169
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADL+VTQLF+D + F+ F + IGI CPI+PG+ PI NY G R+ F
Sbjct: 170 LKEKVDAGADLVVTQLFFDIEAFITFYHKARAIGIECPILPGVFPIQNYSGLKRVIAFND 229
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILT 300
+P +I LE IK+++ AVK YGI+L + ++ GI HLYT N+E+S+ +L
Sbjct: 230 NFVPQKIWDELESIKEDDTAVKEYGINLTVDFIKRFRQEGINGFHLYTFNLERSSRLVLE 289
Query: 301 SLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSG 360
L L+ + + LPW N R +E+VRPIFW NR KSYI RT WD++P+GRWGDS
Sbjct: 290 RLELVAPIENIKPLPWSPSLNNKRAKENVRPIFWKNRTKSYIQRTETWDEFPNGRWGDSR 349
Query: 361 NPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+P++G L + + R ++ + W P +S +DI + +YC
Sbjct: 350 SPAFGELDGWG-INLRYPVEQCIKMWGTP-KSADDI---ASTFARYC 391
>K5WIH4_PHACS (tr|K5WIH4) Methylenetetrahydrofolate reductase OS=Phanerochaete
carnosa (strain HHB-10118-sp) GN=PHACADRAFT_264540 PE=3
SV=1
Length = 624
Score = 377 bits (968), Expect = e-102, Method: Compositional matrix adjust.
Identities = 193/413 (46%), Positives = 262/413 (63%), Gaps = 17/413 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K++ RV +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MKISKKIQQAEKEG--RVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFVDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+T E+ Q ++ ET +HLTCTNMP EKID AL+ KS+G +N+LALRGDPP G+
Sbjct: 59 TSDLTSELVKTCQGLIGTETCMHLTCTNMPTEKIDVALREAKSHGCRNILALRGDPPMGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ EGGF DLV+HIR +YGDYF I VAG+P+ E E+ +
Sbjct: 119 DEWEAVEGGFVHGIDLVQHIRKEYGDYFDIAVAGFPQ--------HVTLPPEERDQEIQW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I TQ+FYD +IF+++V GIT PIVPGI PI + GFI+ T
Sbjct: 171 LKEKVDAGADFIFTQMFYDVEIFIEWVKQVRAAGITIPIVPGIAPIQTWNGFIKSTTLSG 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T IP + LEP K+N+E V+ GI L +MCR+ILA G++ LH YT+N+EK +
Sbjct: 231 TTIPQLVRDQLEPFKNNDEKVREIGIKLVADMCRRILAEPLGVRGLHFYTMNLEKGTRML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ ++ + LPWR+ R E +RPIFWANR KSY+SRT WD+YP+GR+GD
Sbjct: 291 LEELKLVPRVEVVKPLPWRQSLTPNRRTETIRPIFWANRTKSYLSRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
S +P+YG L Y ++R++ L + W P +IEDI L+ ++C L
Sbjct: 351 SRSPAYGELDGYGIWIKQSREEAL-KLWDHPA-TIEDI---SNLFAKFCLGKL 398
>A1C6H3_ASPCL (tr|A1C6H3) Methylenetetrahydrofolate reductase OS=Aspergillus
clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC
3887 / NRRL 1) GN=ACLA_070260 PE=3 SV=1
Length = 619
Score = 377 bits (967), Expect = e-102, Method: Compositional matrix adjust.
Identities = 189/391 (48%), Positives = 257/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
+V SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 QVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP+EK+D AL G N+LALRGDPP ++ + TEGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVDAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ I+TQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDNPDVDLL---------IDHLKEKVDAGSSFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+++V C GIT PI+PGIMPI+ Y FIR + K +IP E + ALEP+K+
Sbjct: 186 FYDTDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPEWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AVK G L EMCRK+LA G+ LH YT+N+ ++ ++L L LI EE+ + R L
Sbjct: 246 DDAAVKEIGKRLIAEMCRKLLAAGLNHLHFYTMNLAQATQSVLDELKLIPSEETPLQRPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRRGEDVRPIFWRNRNSSYIARTQIWDEFPNGRWTDSRSPAFGELDAYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI DI + + Y++
Sbjct: 365 LKGTNEQNIKLWGEP-KSIRDISQIFVRYVE 394
>J4GI53_FIBRA (tr|J4GI53) Methylenetetrahydrofolate reductase OS=Fibroporia
radiculosa (strain TFFH 294) GN=FIBRA_00597 PE=3 SV=1
Length = 603
Score = 377 bits (967), Expect = e-102, Method: Compositional matrix adjust.
Identities = 190/413 (46%), Positives = 264/413 (63%), Gaps = 17/413 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV +K+ DRV +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MKVSQKI--ALAEKEDRVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+T E+ Q ++ +ET +HLTCTNMP EK+D AL+ K +G +NVLALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQKLIGMETCMHLTCTNMPREKVDVALKEAKEHGCRNVLALRGDPPMGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ EGGF DLVKHIR++YGDYF I + G+P+ + E + EL Y
Sbjct: 119 DEWEAVEGGFVHGIDLVKHIRSQYGDYFDIVIPGFPQ--------HVLLPPEEFALELQY 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG++LI TQ+FYD DIF+K+V+ GIT PIVPGI PI + GF + T K
Sbjct: 171 LKEKIDAGSNLIFTQMFYDVDIFIKWVHAVRAAGITIPIVPGIAPIQTWNGFQKATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
TKIP + ALEP K+N+E V+ G L ++CR +L GIK LH YT+N+EK+ +
Sbjct: 231 TKIPQLFLDALEPHKNNDEKVREIGTKLVADVCRYLLDAQIGIKGLHFYTMNLEKATRML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R E +RPIFWANR +SY+SRT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRIQTVKPLPWRQSLTPNRRAETIRPIFWANRTRSYLSRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
S +P+YG L Y +++++ L + W P + + +G L+ ++C L
Sbjct: 351 SRSPAYGELDGYGIWIKQSKEEAL-QLWDSPTSAAD----IGRLFSKFCLGQL 398
>D4AYQ9_ARTBC (tr|D4AYQ9) Methylenetetrahydrofolate reductase OS=Arthroderma
benhamiae (strain ATCC MYA-4681 / CBS 112371)
GN=ARB_01328 PE=3 SV=1
Length = 623
Score = 376 bits (965), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/386 (48%), Positives = 253/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D+ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMPREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+
Sbjct: 186 FYDADNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P +R + DI+V
Sbjct: 365 LKGTNEQNIKLWGKPKSVRDLSDIFV 390
>C4JG55_UNCRE (tr|C4JG55) Methylenetetrahydrofolate reductase OS=Uncinocarpus
reesii (strain UAMH 1704) GN=UREG_02453 PE=3 SV=1
Length = 625
Score = 376 bits (965), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/391 (47%), Positives = 258/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RPSISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFVDITWGAGGRLSDLTAEMVNVSQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++ + TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDWALQSAYKAGCTNILALRGDPPREKEAWAPTEGGFQYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G E + +T+LK KVDAG I+TQ+
Sbjct: 135 VKYIREKYGNHFDIGVAGYPE---------GCEDQEDPELLMTHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIFL +V C + GI PI+PGIMPI+ Y F+R + + K ++P M ALEP K+
Sbjct: 186 FYDVDIFLDWVKRCREQGIKVPILPGIMPISTYAAFLRRSNWVKCRVPPSWMEALEPCKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AVK G L +EMCRKIL GI+ LH YT+N+ +S +L L LI E+ + + L
Sbjct: 246 DDAAVKQIGKKLVSEMCRKILDSGIRHLHFYTMNLAQSTKMVLEELDLIPSSETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + +L+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIKDLSSIFVRFLE 394
>D4DJK8_TRIVH (tr|D4DJK8) Methylenetetrahydrofolate reductase OS=Trichophyton
verrucosum (strain HKI 0517) GN=TRV_07376 PE=3 SV=1
Length = 623
Score = 376 bits (965), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/386 (48%), Positives = 253/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D+ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMPREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+
Sbjct: 186 FYDADNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P +R + DI+V
Sbjct: 365 LKGTNEQNIKLWGEPKSVRDLSDIFV 390
>F2S694_TRIT1 (tr|F2S694) Methylenetetrahydrofolate reductase OS=Trichophyton
tonsurans (strain CBS 112818) GN=TESG_06434 PE=3 SV=1
Length = 623
Score = 376 bits (965), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/386 (48%), Positives = 253/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D+ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMPREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+
Sbjct: 186 FYDADNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P +R + DI+V
Sbjct: 365 LKGTNEQNIKLWGEPKSVRDLSDIFV 390
>C5FFF6_ARTOC (tr|C5FFF6) Methylenetetrahydrofolate reductase OS=Arthroderma otae
(strain ATCC MYA-4605 / CBS 113480) GN=MCYG_02222 PE=3
SV=1
Length = 623
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 188/391 (48%), Positives = 258/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMPREKVDEALQSAFKAGCTNILALRGDPPREKESWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C + GIT PI+PGIMPI+ Y FIR T + K KIP M ALEP+K+
Sbjct: 186 FYDADNFLDWVKRCRKAGITVPIIPGIMPISTYAAFIRRTNWVKCKIPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKQIGRALVSEMCRKLLDNGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +S++D+ + + +L+
Sbjct: 365 LKGTNEQNIKLWGEP-KSVKDLSDIFIRFLE 394
>Q2UEQ8_ASPOR (tr|Q2UEQ8) Methylenetetrahydrofolate reductase OS=Aspergillus
oryzae (strain ATCC 42149 / RIB 40) GN=AO090026000520
PE=3 SV=1
Length = 612
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/392 (47%), Positives = 255/392 (65%), Gaps = 13/392 (3%)
Query: 16 DRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNI 75
+RV SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 14 ERVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSV 73
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET +HLTCT+MP EK+D ALQ +G N+LALRGDPP ++K+ EGG A+D
Sbjct: 74 YGLETCMHLTCTDMPTEKVDAALQAAYKSGCTNILALRGDPPREKEKWEAAEGGLRYAKD 133
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVK+IR KYG++F I V GYPE D D + + +LK KVDAGA ++TQ
Sbjct: 134 LVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDHLKEKVDAGASFVITQ 184
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
+FYDTD+F+ +V C GI PI+PGIMPI Y FIR + K IP + + LEP+K
Sbjct: 185 MFYDTDLFISWVKKCRAKGINVPIIPGIMPIQTYAAFIRRANWTKIHIPEDWLETLEPVK 244
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRS 313
+++ AVK G L +MCR++LA GI LH YT+N+ ++ +L L L+ EE+ I R
Sbjct: 245 NDDAAVKEIGKVLIADMCRRLLAAGINHLHFYTMNLAQATQLVLDELKLLPSEETPIQRP 304
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
LPWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 305 LPWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-I 363
Query: 374 RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + YL+
Sbjct: 364 GLKGTNEQNIQLWGEP-KSIKDLSRLFVRYLE 394
>I8TUJ4_ASPO3 (tr|I8TUJ4) Methylenetetrahydrofolate reductase OS=Aspergillus
oryzae (strain 3.042) GN=Ao3042_05682 PE=3 SV=1
Length = 612
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/392 (47%), Positives = 255/392 (65%), Gaps = 13/392 (3%)
Query: 16 DRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNI 75
+RV SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 14 ERVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSV 73
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET +HLTCT+MP EK+D ALQ +G N+LALRGDPP ++K+ EGG A+D
Sbjct: 74 YGLETCMHLTCTDMPTEKVDAALQAAYKSGCTNILALRGDPPREKEKWEAAEGGLRYAKD 133
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVK+IR KYG++F I V GYPE D D + + +LK KVDAGA ++TQ
Sbjct: 134 LVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDHLKEKVDAGASFVITQ 184
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
+FYDTD+F+ +V C GI PI+PGIMPI Y FIR + K IP + + LEP+K
Sbjct: 185 MFYDTDLFISWVKKCRAKGINVPIIPGIMPIQTYAAFIRRANWTKIHIPEDWLETLEPVK 244
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRS 313
+++ AVK G L +MCR++LA GI LH YT+N+ ++ +L L L+ EE+ I R
Sbjct: 245 NDDAAVKEIGKVLIADMCRRLLAAGINHLHFYTMNLAQATQLVLDELKLLPSEETPIQRP 304
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
LPWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 305 LPWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-I 363
Query: 374 RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + YL+
Sbjct: 364 GLKGTNEQNIQLWGEP-KSIKDLSRLFVRYLE 394
>B8NG74_ASPFN (tr|B8NG74) Methylenetetrahydrofolate reductase OS=Aspergillus
flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 /
JCM 12722 / SRRC 167) GN=AFLA_134130 PE=3 SV=1
Length = 612
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/392 (47%), Positives = 255/392 (65%), Gaps = 13/392 (3%)
Query: 16 DRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNI 75
+RV SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 14 ERVGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSV 73
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET +HLTCT+MP EK+D ALQ +G N+LALRGDPP ++K+ EGG A+D
Sbjct: 74 YGLETCMHLTCTDMPTEKVDAALQAAYKSGCTNILALRGDPPREKEKWEAAEGGLRYAKD 133
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVK+IR KYG++F I V GYPE D D + + +LK KVDAGA ++TQ
Sbjct: 134 LVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDHLKEKVDAGASFVITQ 184
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
+FYDTD+F+ +V C GI PI+PGIMPI Y FIR + K IP + + LEP+K
Sbjct: 185 MFYDTDLFISWVKKCRAKGINVPIIPGIMPIQTYAAFIRRANWTKIHIPEDWLETLEPVK 244
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRS 313
+++ AVK G L +MCR++LA GI LH YT+N+ ++ +L L L+ EE+ I R
Sbjct: 245 NDDAAVKEIGKVLIADMCRRLLAAGINHLHFYTMNLAQATQLVLDELKLLPSEETPIQRP 304
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
LPWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 305 LPWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-I 363
Query: 374 RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + YL+
Sbjct: 364 GLKGTNEQNIQLWGEP-KSIKDLSRLFVRYLE 394
>E0XYM8_9CHLR (tr|E0XYM8) Methylenetetrahydrofolate reductase OS=uncultured
Chloroflexi bacterium HF0770_09E03 PE=3 SV=1
Length = 589
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/399 (46%), Positives = 252/399 (63%), Gaps = 24/399 (6%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
+ +SFEFFPPK++ +DNL+ R+DRM + P++ DITWGAGGSTA TLE++ +Q
Sbjct: 15 KTFYSFEFFPPKSDYALDNLYSRIDRMASLQPAYIDITWGAGGSTAKRTLEMSKTIQKYF 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+E M+HLTCTNMPV I+ L K NGL N+LALRGDPP G ++ E GF DL
Sbjct: 75 GLEVMMHLTCTNMPVSSINKVLINAKENGLSNILALRGDPPDGAVEWENNEKGFNYGIDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR +GD F + V GYP++H + D +++YLK KVDAG++++VTQL
Sbjct: 135 VRYIRKAFGDDFFLGVGGYPDSHQEQTDFDL---------DISYLKEKVDAGSNIVVTQL 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL F + C IGI PI+PGIMPI+NY FI+ T FC +P + LE +K
Sbjct: 186 FYDVDKFLVFRDKCSAIGIHVPIIPGIMPIHNYSRFIKFTQFCDVTVPDSVSKTLESLKH 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPW 316
++ +V YGI GT MC K++A G+ LH YTLN+E S IL SLGL +R LPW
Sbjct: 246 DDSSVIHYGIEQGTAMCEKLIAEGVPGLHFYTLNLEHSVSRILESLGLASVQGSARELPW 305
Query: 317 RRPTNVFR-VREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRP 375
R+ T R EDVRPI+W+NRP SY++RT WD +P+GRWGD +P++G L Y +R
Sbjct: 306 RQSTVGDRKTTEDVRPIYWSNRPVSYLTRTETWDDFPNGRWGDITSPTFGELNQYHSIRA 365
Query: 376 -------RARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+ R KKL W P+ S+ DI V ++ +C
Sbjct: 366 GSKSEKGKTRRKKL---WGEPI-SVNDITKV---FVSFC 397
>F2TKH4_AJEDA (tr|F2TKH4) Methylenetetrahydrofolate reductase OS=Ajellomyces
dermatitidis (strain ATCC 18188 / CBS 674.68)
GN=BDDG_06682 PE=3 SV=1
Length = 633
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/386 (48%), Positives = 257/386 (66%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++K+ TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDTALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G D E + +LK KVDAG I+TQ+
Sbjct: 135 VKYIRDKYGNHFDIGVAGYPE------GCDDQDDPELL---MEHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GIT PI+PGIMPI+ Y FIR + + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFLTWVEKCRQKGITVPIIPGIMPIHTYAAFIRRSNWTKIRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSL 314
++ AV+ G L +MC+KILA GI LH YT+N++++ IL LGLI K + + L
Sbjct: 246 DDAAVRNLGKSLVADMCKKILASGIYHLHFYTMNLQQATKMILDELGLIPSHKTPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P L+ + +I++
Sbjct: 365 LKGTNEQNIKLWGEPKSLKELSEIFI 390
>C5GPB7_AJEDR (tr|C5GPB7) Methylenetetrahydrofolate reductase OS=Ajellomyces
dermatitidis (strain ER-3 / ATCC MYA-2586) GN=BDCG_06426
PE=3 SV=1
Length = 633
Score = 375 bits (964), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/386 (48%), Positives = 257/386 (66%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++K+ TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDTALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G D E + +LK KVDAG I+TQ+
Sbjct: 135 VKYIRDKYGNHFDIGVAGYPE------GCDDQDDPELL---MEHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GIT PI+PGIMPI+ Y FIR + + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFLTWVEKCRQKGITVPIIPGIMPIHTYAAFIRRSNWTKIRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSL 314
++ AV+ G L +MC+KILA GI LH YT+N++++ IL LGLI K + + L
Sbjct: 246 DDAAVRNLGKSLVADMCKKILASGIYHLHFYTMNLQQATKMILDELGLIPSHKTPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P L+ + +I++
Sbjct: 365 LKGTNEQNIKLWGEPKSLKELSEIFI 390
>C5JE18_AJEDS (tr|C5JE18) Methylenetetrahydrofolate reductase OS=Ajellomyces
dermatitidis (strain SLH14081) GN=BDBG_00602 PE=3 SV=1
Length = 633
Score = 375 bits (963), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/386 (48%), Positives = 257/386 (66%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++K+ TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDTALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G D E + +LK KVDAG I+TQ+
Sbjct: 135 VKYIRDKYGNHFDIGVAGYPE------GCDDQDDPELL---MEHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GIT PI+PGIMPI+ Y FIR + + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFLTWVERCRQKGITVPIIPGIMPIHTYAAFIRRSNWTKIRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSL 314
++ AV+ G L +MC+KILA GI LH YT+N++++ IL LGLI K + + L
Sbjct: 246 DDAAVRNLGKSLVADMCKKILASGIYHLHFYTMNLQQATKMILDELGLIPSHKTPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P L+ + +I++
Sbjct: 365 LKGTNEQNIKLWGEPKSLKELSEIFI 390
>A1DH45_NEOFI (tr|A1DH45) Methylenetetrahydrofolate reductase OS=Neosartorya
fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 /
NRRL 181) GN=NFIA_086570 PE=3 SV=1
Length = 615
Score = 375 bits (963), Expect = e-101, Method: Compositional matrix adjust.
Identities = 186/391 (47%), Positives = 257/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
RV SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RVGISFEFFPPKTAQGVQNLYDRMDRMHSLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP+EK++ AL G N+LALRGDPP ++ + TEGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVNAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ ++TQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDNPDVDQL---------IDHLKEKVDAGSSFVITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++V C GIT PI+PGIMPI+ Y FIR + K +IP + + ALEP+K+
Sbjct: 186 FYDIDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AVK G L +MCR++LA GIK LH YT+N+ ++ A+L L LI EE+ + R L
Sbjct: 246 DDAAVKEIGKRLVADMCRRLLAAGIKHLHFYTMNLAQATQAVLEELKLIPSEETPLQRPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLALNRRGEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDAYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI D+ + + YL+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIRDVTQIFVRYLE 394
>F2SQ86_TRIRC (tr|F2SQ86) Methylenetetrahydrofolate reductase OS=Trichophyton
rubrum (strain ATCC MYA-4607 / CBS 118892) GN=TERG_04751
PE=3 SV=1
Length = 623
Score = 375 bits (962), Expect = e-101, Method: Compositional matrix adjust.
Identities = 186/386 (48%), Positives = 253/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP E++D+ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMPRERVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+
Sbjct: 186 FYDADNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P +R + DI+V
Sbjct: 365 LKGTNEQNIKLWGEPKSVRDLSDIFV 390
>B0XSG0_ASPFC (tr|B0XSG0) Methylenetetrahydrofolate reductase OS=Neosartorya
fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
GN=AFUB_027060 PE=3 SV=1
Length = 615
Score = 374 bits (961), Expect = e-101, Method: Compositional matrix adjust.
Identities = 186/391 (47%), Positives = 256/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
RV SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RVGISFEFFPPKTAQGVQNLYDRMDRMHSLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP+EK++ AL G N+LALRGDPP ++ + TEGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVNAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ ++TQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDNPDVDQL---------IDHLKEKVDAGSSFVITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++V C GIT PI+PGIMPI+ Y FIR + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AVK G L +MCR++LA GI LH YT+N+ ++ A+L L LI EE+ + R L
Sbjct: 246 DDAAVKEIGKRLVADMCRRLLAAGINHLHFYTMNLAQATQAVLEELKLIPSEETPLQRPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLALNRRGEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDAYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI DI + + YL+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIRDITQIFVRYLE 394
>F2PWP0_TRIEC (tr|F2PWP0) Methylenetetrahydrofolate reductase OS=Trichophyton
equinum (strain ATCC MYA-4606 / CBS 127.97)
GN=TEQG_05311 PE=3 SV=1
Length = 623
Score = 373 bits (958), Expect = e-101, Method: Compositional matrix adjust.
Identities = 186/386 (48%), Positives = 252/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+M EK+D+ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMSREKVDDALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C Q GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+
Sbjct: 186 FYDADNFLDWVKKCRQAGIKVPIIPGIMPISTYAAFIRRTNWVKCAVPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKQIGKALVSEMCRKLLENGINHLHFYTMNLAQSTTMVLEELNLKPSTETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P +R + DI+V
Sbjct: 365 LKGTNEQNIKLWGEPKSVRDLSDIFV 390
>D8Q1D9_SCHCM (tr|D8Q1D9) Methylenetetrahydrofolate reductase OS=Schizophyllum
commune (strain H4-8 / FGSC 9210) GN=SCHCODRAFT_67475
PE=3 SV=1
Length = 603
Score = 373 bits (958), Expect = e-101, Method: Compositional matrix adjust.
Identities = 179/372 (48%), Positives = 244/372 (65%), Gaps = 12/372 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K++ D +V +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 1 MKISQKIQQSAKDD--KVWWSFEYFPPRTAQGLQNLLDRIERMRGLGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+T E+ Q ++ +ET +HLTCTNMP EK+D AL+ K++G +N+LALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGIETCMHLTCTNMPKEKVDIALKDAKAHGCRNILALRGDPPAGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ TEGGF DLV+HIR +YGDYF I V G+P+ E E+ +
Sbjct: 119 DEWEATEGGFVHGIDLVRHIRREYGDYFDIAVPGFPQHM--------TLPKEERDQEMKW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG + I TQ+FYD IF+ +V + GIT PIVPGI PI + GF+R T K
Sbjct: 171 LKEKIDAGVNFIFTQMFYDVQIFIDWVREVRAAGITIPIVPGIAPIQTWNGFLRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T IP M ALEP+K+++E V+ G L EMCR+IL+ GI+ LH YT+N+EK+ +
Sbjct: 231 TIIPQHFMDALEPVKNDDEKVRATGTKLVAEMCRRILSEDIGIRGLHFYTMNLEKATRML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R +E +RPIFWANR KSYISRT WD+YP+GR+GD
Sbjct: 291 LEELQLVPRVETIKPLPWRQCLTPSRRQESIRPIFWANRTKSYISRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDY 370
S +P+YG L Y
Sbjct: 351 SRSPAYGELDGY 362
>Q0CXY7_ASPTN (tr|Q0CXY7) Methylenetetrahydrofolate reductase OS=Aspergillus
terreus (strain NIH 2624 / FGSC A1156) GN=ATEG_01447
PE=3 SV=1
Length = 619
Score = 373 bits (957), Expect = e-101, Method: Compositional matrix adjust.
Identities = 187/391 (47%), Positives = 255/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP+EK+D ALQ+ G N+LALRGDPP ++K+ T+GGF A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVDAALQSAYKAGCTNILALRGDPPREKEKWEATDGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ IVTQ+
Sbjct: 135 VKYIRDKYGNHFDIGVGGYPEGADDNPDVDLL---------IDHLKEKVDAGSSFIVTQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+ +V C GI PI+PGIMPI Y F+R + K +IP E + ALEP+K+
Sbjct: 186 FYDTDNFINWVKKCRAKGINVPIIPGIMPIQTYAAFMRRANWTKIRIPPEWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AVK G L +MCR++LA GI LH YT+N+ +S +L L L EE+ + + L
Sbjct: 246 DDAAVKEIGKGLIADMCRRLLAAGINHLHFYTMNLAQSTQLVLEELNLTPSEETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRRGEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI D+ + + ++Q
Sbjct: 365 LKGTNEQNIKLWGEP-KSIRDLAHIFVKFMQ 394
>Q4X140_ASPFU (tr|Q4X140) Methylenetetrahydrofolate reductase OS=Neosartorya
fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 /
FGSC A1100) GN=AFUA_2G11300 PE=3 SV=1
Length = 615
Score = 373 bits (957), Expect = e-101, Method: Compositional matrix adjust.
Identities = 185/391 (47%), Positives = 256/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
RV SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RVGISFEFFPPKTAQGVQNLYDRMDRMHSLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP+EK++ AL G N+LALRGDPP ++ + TEGG A+DL
Sbjct: 75 GLETCMHLTCTDMPLEKVNAALSAAYKAGCTNILALRGDPPRDKEAWEATEGGLRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR K+G++F I V GYPE D D + + +LK KVDAG+ ++TQ+
Sbjct: 135 VKYIREKFGNHFDIGVGGYPEGADDNPDVDQL---------IDHLKEKVDAGSSFVITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+++V C GIT PI+PGIMPI+ Y FIR + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFIEWVKKCRAKGITVPIIPGIMPISTYAAFIRRANWTKARIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AVK G L +MCR++LA GI LH YT+N+ ++ A+L L LI EE+ + R L
Sbjct: 246 DDAAVKEIGKRLVADMCRRLLAAGINHLHFYTMNLAQATQAVLEELKLIPSEETPLQRPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLALNRRGEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDAYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI DI + + YL+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIRDITQIFVRYLE 394
>A8N945_COPC7 (tr|A8N945) Methylenetetrahydrofolate reductase OS=Coprinopsis
cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC
9003) GN=CC1G_00920 PE=3 SV=2
Length = 614
Score = 372 bits (956), Expect = e-100, Method: Compositional matrix adjust.
Identities = 186/414 (44%), Positives = 260/414 (62%), Gaps = 17/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
M++ +K++ D +V +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MRISQKIQQSAKED--KVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+T E+ Q ++ +ET +HLTCTNMP EK+D AL+ K +G +N+LALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGIETCMHLTCTNMPREKVDTALKEAKEHGCRNILALRGDPPMGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ EGGF DLV+HIR YGDYF I V G+P+ + E NE+ +
Sbjct: 119 DEWEAVEGGFVHGIDLVRHIRKHYGDYFDIAVPGFPQHM--------LLPPEERDNEIRW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+D G + I TQ+F+D DIF+ +V GIT PIVPGIMPI + GFI+ T
Sbjct: 171 LKEKIDEGVNFIFTQMFFDVDIFISWVKAVRAAGITIPIVPGIMPIQTWNGFIKATNLAS 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKIL--AHGIKTLHLYTLNMEKSALAI 298
TKIP + ALEP+K ++E V+ G L +MCRKIL GI+ LH YT+N+EK +
Sbjct: 231 TKIPQFFLDALEPVKSDDEKVREVGTKLVADMCRKILDSGLGIRGLHFYTMNLEKGTRML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R E +RPIFWANR KSYISRT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRIETIKPLPWRQCLTPNRRNETIRPIFWANRTKSYISRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFLD 412
S +P+YG + Y + ++ L + W P ++E++ V L+ ++C LD
Sbjct: 351 SRSPAYGEIDGYGTAIKQTKENAL-KLWGYPT-TLEEVSV---LFAKFCKGELD 399
>G7X5I8_ASPKW (tr|G7X5I8) Methylenetetrahydrofolate reductase OS=Aspergillus
kawachii (strain NBRC 4308) GN=AKAW_00461 PE=3 SV=1
Length = 626
Score = 372 bits (956), Expect = e-100, Method: Compositional matrix adjust.
Identities = 184/391 (47%), Positives = 256/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ G N+LALRGDPP ++ + +GGF A+DL
Sbjct: 75 GLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDKEAWEAADGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR+KYG++F I V GYPE D D + + +LK KVDAGA ++TQ+
Sbjct: 135 VKYIRSKYGNHFDIGVGGYPEGADDNPDVDQL---------IDHLKEKVDAGASFVITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+ +V C GI PI+PGIMPI Y FIR + + KT+IP + + ALEP+K+
Sbjct: 186 FYDTDNFIGWVKKCRDRGIHVPIIPGIMPIQTYAAFIRRSNWTKTRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AV+ G L +MCR+++A GI LH YT+N+ +S +L L L+ EE+ + R+L
Sbjct: 246 DDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLDELNLMPSEETPLQRAL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +S+ D+ V + +L+
Sbjct: 365 LKGTNEQNIKLWGEP-KSLRDLTHVFVDFLE 394
>G3Y2A7_ASPNA (tr|G3Y2A7) Methylenetetrahydrofolate reductase OS=Aspergillus
niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB
Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
GN=ASPNIDRAFT_55539 PE=3 SV=1
Length = 626
Score = 372 bits (954), Expect = e-100, Method: Compositional matrix adjust.
Identities = 185/386 (47%), Positives = 253/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ G N+LALRGDPP ++ + +GGF A+DL
Sbjct: 75 GLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDKEAWEAADGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR+KYG++F I V GYPE G+D E + +LK KVDAGA ++TQ+
Sbjct: 135 VKYIRSKYGNHFDIGVGGYPE------GADDNPDVEQL---IDHLKEKVDAGASFVITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+ +V C GI PI+PGIMPI Y FIR + + KT+IP + + ALEP+K+
Sbjct: 186 FYDTDNFIGWVKKCRDRGIHVPIIPGIMPIQTYAAFIRRSDWTKTRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AV+ G L +MCR+++A GI LH YT+N+ +S +L L L+ EE+ + R+L
Sbjct: 246 DDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLDELNLMPSEETPLQRAL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P LR + I+V
Sbjct: 365 LKGTNEQNIKLWGEPKSLRDLTHIFV 390
>A2QCE3_ASPNC (tr|A2QCE3) Methylenetetrahydrofolate reductase OS=Aspergillus
niger (strain CBS 513.88 / FGSC A1513) GN=An02g03270
PE=3 SV=1
Length = 626
Score = 372 bits (954), Expect = e-100, Method: Compositional matrix adjust.
Identities = 185/386 (47%), Positives = 253/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM A PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 RTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ G N+LALRGDPP ++ + +GGF A+DL
Sbjct: 75 GLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDKEAWEAADGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR+KYG++F I V GYPE G+D E + +LK KVDAGA ++TQ+
Sbjct: 135 VKYIRSKYGNHFDIGVGGYPE------GADDNPDVEQL---IDHLKEKVDAGASFVITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+ +V C GI PI+PGIMPI Y FIR + + KT+IP + + ALEP+K+
Sbjct: 186 FYDTDNFIGWVKKCRDRGIHVPIIPGIMPIQTYAAFIRRSDWTKTRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AV+ G L +MCR+++A GI LH YT+N+ +S +L L L+ EE+ + R+L
Sbjct: 246 DDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLDELNLMPSEETPLQRAL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P LR + I+V
Sbjct: 365 LKGTNEQNIKLWGEPKSLRDLTHIFV 390
>E6ZP86_SPORE (tr|E6ZP86) Methylenetetrahydrofolate reductase OS=Sporisorium
reilianum (strain SRZ2) GN=sr15499 PE=3 SV=1
Length = 649
Score = 371 bits (952), Expect = e-100, Method: Compositional matrix adjust.
Identities = 183/393 (46%), Positives = 248/393 (63%), Gaps = 15/393 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R+ +SFE+FPP+T G+ NL++R++RM P F DITW AGG T+D+T + + +
Sbjct: 31 RIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGRTSDLTASLVKTVHTYI 90
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP EKID AL+ K G +N+LALRGDPP GQ ++ GF A+ L
Sbjct: 91 GLETCMHLTCTNMPREKIDTALKEAKEFGCRNILALRGDPPAGQSEWEPHAAGFTSAKQL 150
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR YGDYF I VAG+PE HP+A+ + + EL LK K+DAGAD I TQ+
Sbjct: 151 VEYIRENYGDYFAIAVAGFPEGHPEAV--------DGPEKELERLKEKIDAGADFIFTQM 202
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIF K+V D GITCPIVPG+MPI Y GF R T T +P AL+P+KD
Sbjct: 203 FYDFDIFAKWVKDVRAAGITCPIVPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVKD 262
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
+++ V+ G L EMC+KI+ GI LH+YT+N+EK + +L LGL L
Sbjct: 263 DDQKVRDVGTRLVGEMCKKIVGTGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPL 322
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PW R E +RPIFWANR KSY++RT WD++P+GRWGD+ +P+YG + Y ++
Sbjct: 323 PWTPSLTPKRREEKIRPIFWANRAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VK 381
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
R +++ E W P S+ED V L+ +C
Sbjct: 382 LRYSNEEAKEMWGAPT-SLED---VKALFENFC 410
>F0U6Q8_AJEC8 (tr|F0U6Q8) Methylenetetrahydrofolate reductase OS=Ajellomyces
capsulata (strain H88) GN=HCEG_00849 PE=3 SV=1
Length = 633
Score = 370 bits (951), Expect = e-100, Method: Compositional matrix adjust.
Identities = 184/386 (47%), Positives = 255/386 (66%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D A+Q+ G N+LALRGDPP ++K+ EGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDAAIQSAFKAGCTNILALRGDPPREKEKWEAIEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE D D + + +LK KVDAG I+TQ+
Sbjct: 135 VKYIRDKYGNHFDIGVAGYPEGCDDQDDPDLL---------MQHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +VN C + GIT PI+PGIMPI+ Y FIR + + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFLAWVNKCRENGITVPIIPGIMPIHTYAAFIRRSNWTKIRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSL 314
++ AV+ G L MCRKILA GI LH YT+N++++ +L L LI K + + L
Sbjct: 246 DDAAVRNLGKSLVANMCRKILAAGIYHLHFYTMNLQQATKMVLGELELIPSHKTPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P L+ + +I+V
Sbjct: 365 LKGTNEQNIKLWGEPKSLKELSEIFV 390
>C0NNE8_AJECG (tr|C0NNE8) Methylenetetrahydrofolate reductase OS=Ajellomyces
capsulata (strain G186AR / H82 / ATCC MYA-2454 / RMSCC
2432) GN=HCBG_04275 PE=3 SV=1
Length = 633
Score = 370 bits (951), Expect = e-100, Method: Compositional matrix adjust.
Identities = 184/386 (47%), Positives = 255/386 (66%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D A+Q+ G N+LALRGDPP ++K+ EGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDAAIQSAFKAGCTNILALRGDPPREKEKWEAIEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE D D + + +LK KVDAG I+TQ+
Sbjct: 135 VKYIRDKYGNHFDIGVAGYPEGCDDQDDPDLL---------MQHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +VN C + GIT PI+PGIMPI+ Y FIR + + K +IP + + ALEP+K+
Sbjct: 186 FYDVDNFLAWVNKCRENGITVPIIPGIMPIHTYAAFIRRSNWTKIRIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSL 314
++ AV+ G L MCRKILA GI LH YT+N++++ +L L LI K + + L
Sbjct: 246 DDAAVRNLGKSLVANMCRKILAAGIYHLHFYTMNLQQATKMVLGELELIPSHKTPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-VG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P L+ + +I+V
Sbjct: 365 LKGTNEQNIKLWGEPKSLKELSEIFV 390
>C1GYS1_PARBA (tr|C1GYS1) Methylenetetrahydrofolate reductase OS=Paracoccidioides
brasiliensis (strain ATCC MYA-826 / Pb01) GN=PAAG_03665
PE=3 SV=1
Length = 629
Score = 370 bits (951), Expect = e-100, Method: Compositional matrix adjust.
Identities = 180/383 (46%), Positives = 255/383 (66%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++ +E
Sbjct: 18 ISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++K+ TEGGF A+DLVK+
Sbjct: 78 TCMHLTCTDMPREKVDAALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++F I VAGYPE G + + + +LK KVDAG I+TQ+FYD
Sbjct: 138 IRVKYGNHFDIGVAGYPE---------GCEDQDDPELLMQHLKEKVDAGGTFIITQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL +V +C + GI PI+PGIMPI+ Y FIR + + K +IP + ALEP+K+++
Sbjct: 189 VDNFLAWVKNCREKGIKVPIIPGIMPIHTYAAFIRRSNWTKIQIPPGWLEALEPVKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MC+K+LA GI LH YT+N++++ +L LGLI E+ + + LPWR
Sbjct: 249 AVRNLGKSLVANMCKKMLASGIHHLHFYTMNLQQATKMVLDELGLIPSHETPLQKPLPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y + +
Sbjct: 309 QSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ + W P L+ + +I++
Sbjct: 368 TNEQNIQLWGKPKSLKELSEIFI 390
>G4TUD6_PIRID (tr|G4TUD6) Methylenetetrahydrofolate reductase OS=Piriformospora
indica (strain DSM 11827) GN=PIIN_08899 PE=3 SV=1
Length = 599
Score = 370 bits (950), Expect = e-100, Method: Compositional matrix adjust.
Identities = 187/411 (45%), Positives = 258/411 (62%), Gaps = 21/411 (5%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
M++ EK+ + RV +SFE+FPP+T G NL +R++RM P F DITW AGG
Sbjct: 1 MRITEKIEKAEKQN--RVWWSFEYFPPRTAQGFQNLVDRIERMRHLGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T E+ Q+++ +ET +HLTCTNMP EK+D AL+ KS+G +N+LALRGDPP GQ
Sbjct: 59 TSELTSEMVKTCQSLLGIETCMHLTCTNMPSEKVDIALREAKSHGCRNILALRGDPPAGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ +GGF DLV+HIR YGDYF I VAG+PE + + E Q EL Y
Sbjct: 119 DEWTAVDGGFVHGIDLVRHIRKNYGDYFEIAVAGFPE--------HAMLSEEEQQVELQY 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGA I TQ+FYD D+F+++V+ + GIT PIVPGI PI + GF++ T K
Sbjct: 171 LKEKIDAGASFIFTQMFYDLDLFVRWVHSVRKAGITVPIVPGINPIQTWNGFMKATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKIL--AHGIKTLHLYTLNMEKSALAI 298
IP + LEP K+N+E V+ G L ++CR IL GI+ LH YT+N+EK +
Sbjct: 231 ITIPQSYLDVLEPHKNNDEKVRELGTKLVADLCRGILNAGLGIRGLHFYTMNLEKGTRML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L + + + LPWR+ R E +RPIFWANR KSY+SRT WDQYP+GR+GD
Sbjct: 291 LEELSFVPRVETVKPLPWRQCLTPSRRSETIRPIFWANRTKSYLSRTENWDQYPNGRYGD 350
Query: 359 SGNPSYGALTDYQFMRPRARD--KKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+ +P+YG L Y +++ +KL W P ++ EDI G L+ +C
Sbjct: 351 ARSPAYGELDGYGISLKHSKEDAQKL---WGHP-QTKEDI---GKLFATFC 394
>M5G436_DACSP (tr|M5G436) Methylenetetrahydrofolate reduct OS=Dacryopinax sp.
(strain DJM 731) GN=DACRYDRAFT_21039 PE=4 SV=1
Length = 602
Score = 369 bits (948), Expect = e-100, Method: Compositional matrix adjust.
Identities = 179/372 (48%), Positives = 243/372 (65%), Gaps = 14/372 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K++ RV +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 1 MKITKKLQQAEHEG--RVWWSFEYFPPRTAPGMQNLLDRIERMRELGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T E+ Q + +ET +HLTCTNMP K+D AL+ K G +NVLALRGDPP GQ
Sbjct: 59 TSELTSELVRCCQRDLGIETCMHLTCTNMPAAKVDIALKEAKQWGCRNVLALRGDPPFGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+++ +TE GF DLVKHIRA YGDYF + VAG+PEAH ++E+ +
Sbjct: 119 EQWTKTEDGFEHGIDLVKHIRAGYGDYFDVAVAGFPEAH----------NRHDREDEMKF 168
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK+K+DAG D I TQ+F+D D+F+ +V GITCPIVPGIMPI + GF R T K
Sbjct: 169 LKNKIDAGVDFIFTQMFWDVDLFIDWVKAVRAAGITCPIVPGIMPIQTWNGFQRATSLAK 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
P ++AALEP K+++E V+ G + +MCRKILA GI+ LH YT+N+E+ +
Sbjct: 229 ISTPPALLAALEPYKNDDEKVREIGTQIVADMCRKILAADIGIRGLHFYTMNLERGTRML 288
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L +L + ++ R LPWR+ R E++RPIFWANR KSYI RT WD+YP+GR+GD
Sbjct: 289 LEALNFVPHIEVVRPLPWRQALTPTRRGENIRPIFWANRVKSYIHRTENWDEYPNGRFGD 348
Query: 359 SGNPSYGALTDY 370
S +P+YG L Y
Sbjct: 349 SRSPAYGELDGY 360
>B6H6J4_PENCW (tr|B6H6J4) Methylenetetrahydrofolate reductase OS=Penicillium
chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin
54-1255) GN=Pc15g00480 PE=3 SV=1
Length = 610
Score = 369 bits (948), Expect = e-100, Method: Compositional matrix adjust.
Identities = 181/383 (47%), Positives = 248/383 (64%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
SFEFFPPKT GV NL++RMDRM PSF DITWGAGG +D+T E+ + Q++ +E
Sbjct: 18 ISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLSDLTCEMVSVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+MPVEK+D ALQ G N+LALRGDPP ++ + E GF A+DLVK+
Sbjct: 78 TCMHLTCTDMPVEKVDQALQAAYKAGCTNILALRGDPPREKEAWEAAENGFCYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++F I V GYPE D D + + +LK KVDAG+ +VTQ+FYD
Sbjct: 138 IREKYGNHFDIGVGGYPEGADDNTDVDQL---------IDHLKEKVDAGSSFVVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
+ F+++V C GI PI+PGIMPI Y FIR + + K K+P+E M ALEP+K+++
Sbjct: 189 AENFIEWVKKCRAKGINVPIIPGIMPIQTYASFIRRSNWTKVKVPSEWMEALEPVKNDDS 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MCR+++A GIK LH YT+N+ ++ +L L L E+S I R LPWR
Sbjct: 249 AVRDIGKTLIANMCRQLIAAGIKHLHFYTMNLAQATQLVLKELELTPSEDSPIQRPLPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRP+FW NR SY++RT WD+YP+GRW DS +P++G L Y + +
Sbjct: 309 PSLGLGRRSEDVRPVFWRNRNSSYVARTQTWDEYPNGRWTDSRSPAFGELDAYG-VGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ + W P ++ I DI+V
Sbjct: 368 TNEQNIKLWGEPKSIKDISDIFV 390
>E9DEV7_COCPS (tr|E9DEV7) Methylenetetrahydrofolate reductase OS=Coccidioides
posadasii (strain RMSCC 757 / Silveira) GN=CPSG_08357
PE=3 SV=1
Length = 629
Score = 369 bits (948), Expect = 1e-99, Method: Compositional matrix adjust.
Identities = 183/391 (46%), Positives = 255/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM P+F DITWGAGG +D+T E+ N Q++
Sbjct: 15 RPSISFEFFPPKTAQGVQNLYDRMDRMHGLGPAFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ G N+LALRGDPP ++ + TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDWALQCAHKAGCTNILALRGDPPREKESWAPTEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G E + + +LK KVDAG I+TQ+
Sbjct: 135 VKYIREKYGNHFDIGVAGYPE---------GCEDEEDPETLMKHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIFL +V C + GI PI+PGIMPI+ Y F+R + + K K+P M ALEP+K+
Sbjct: 186 FYDVDIFLDWVKRCRENGIQVPILPGIMPISTYASFLRRSNWVKCKVPESWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSL 314
++ AVK G L MC+KIL GI+ LH YT+N+ ++ +L L LI E+ + + L
Sbjct: 246 DDAAVKQIGKKLVANMCQKILDSGIRHLHFYTMNLAQATKMVLEELKLIPSYETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRRDEDVRPIFWRHRHQSYVARTQTWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + +L+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIKDLSAIFIRFLE 394
>C5PJM0_COCP7 (tr|C5PJM0) Methylenetetrahydrofolate reductase OS=Coccidioides
posadasii (strain C735) GN=CPC735_022180 PE=3 SV=1
Length = 629
Score = 369 bits (948), Expect = 1e-99, Method: Compositional matrix adjust.
Identities = 183/391 (46%), Positives = 255/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM P+F DITWGAGG +D+T E+ N Q++
Sbjct: 15 RPSISFEFFPPKTAQGVQNLYDRMDRMHGLGPAFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ G N+LALRGDPP ++ + TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDWALQCAHKAGCTNILALRGDPPREKESWAPTEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G E + + +LK KVDAG I+TQ+
Sbjct: 135 VKYIREKYGNHFDIGVAGYPE---------GCEDEEDPETLMKHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIFL +V C + GI PI+PGIMPI+ Y F+R + + K K+P M ALEP+K+
Sbjct: 186 FYDVDIFLDWVKRCRENGIQVPILPGIMPISTYASFLRRSNWVKCKVPESWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSL 314
++ AVK G L MC+KIL GI+ LH YT+N+ ++ +L L LI E+ + + L
Sbjct: 246 DDAAVKQIGKKLVANMCQKILDSGIRHLHFYTMNLAQATKMVLEELKLIPSYETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRRDEDVRPIFWRHRHQSYVARTQTWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + +L+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIKDLSAIFIRFLE 394
>K9H2D3_PEND1 (tr|K9H2D3) Methylenetetrahydrofolate reductase OS=Penicillium
digitatum (strain Pd1 / CECT 20795) GN=PDIP_10790 PE=3
SV=1
Length = 610
Score = 369 bits (947), Expect = 1e-99, Method: Compositional matrix adjust.
Identities = 181/383 (47%), Positives = 248/383 (64%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
SFEFFPPKT GV NL++RMDRM PSF DITWGAGG +D+T E+ + Q++ +E
Sbjct: 18 ISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLSDLTCEMVSVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+MP+EK+D ALQ G N+LALRGDPP ++ + E GF A+DLVK+
Sbjct: 78 TCMHLTCTDMPLEKVDQALQAAYKAGCTNILALRGDPPRDKETWEAAENGFCYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++F I V GYPE D D + + +LK KVDAG+ +VTQ+FYD
Sbjct: 138 IRNKYGNHFDIGVGGYPEGADDNADVDQL---------IDHLKEKVDAGSSFVVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V C GIT PI+PGIMPI Y FIR + + K +P + M ALEP+K+++
Sbjct: 189 ADNFIEWVKKCRAKGITVPIIPGIMPIQTYASFIRRSSWTKVHVPPQWMEALEPVKNDDS 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSLPWR 317
AV+ G L MCR+++A GIK LH YT+N+ ++ +L L L EES I R+LPWR
Sbjct: 249 AVREIGKTLIANMCRQLIAAGIKHLHFYTMNLAQATQLVLKELDLSPSEESPIQRALPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRP+FW NR SY++RT WD+YP+GRW DS +P++G L Y + +
Sbjct: 309 PSLGLGRRTEDVRPVFWRNRNSSYVARTQTWDEYPNGRWTDSRSPAFGELDAYG-VGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ + W P ++ I DI+V
Sbjct: 368 TNEQNIKLWGEPKSVKDISDIFV 390
>K9GDB8_PEND2 (tr|K9GDB8) Methylenetetrahydrofolate reductase OS=Penicillium
digitatum (strain PHI26 / CECT 20796) GN=PDIG_06110 PE=3
SV=1
Length = 610
Score = 369 bits (947), Expect = 1e-99, Method: Compositional matrix adjust.
Identities = 181/383 (47%), Positives = 248/383 (64%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
SFEFFPPKT GV NL++RMDRM PSF DITWGAGG +D+T E+ + Q++ +E
Sbjct: 18 ISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLSDLTCEMVSVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+MP+EK+D ALQ G N+LALRGDPP ++ + E GF A+DLVK+
Sbjct: 78 TCMHLTCTDMPLEKVDQALQAAYKAGCTNILALRGDPPRDKETWEAAENGFCYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++F I V GYPE D D + + +LK KVDAG+ +VTQ+FYD
Sbjct: 138 IRNKYGNHFDIGVGGYPEGADDNADVDQL---------IDHLKEKVDAGSSFVVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V C GIT PI+PGIMPI Y FIR + + K +P + M ALEP+K+++
Sbjct: 189 ADNFIEWVKKCRAKGITVPIIPGIMPIQTYASFIRRSSWTKVHVPPQWMEALEPVKNDDS 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSLPWR 317
AV+ G L MCR+++A GIK LH YT+N+ ++ +L L L EES I R+LPWR
Sbjct: 249 AVREIGKTLIANMCRQLIAAGIKHLHFYTMNLAQATQLVLKELDLSPSEESPIQRALPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRP+FW NR SY++RT WD+YP+GRW DS +P++G L Y + +
Sbjct: 309 PSLGLGRRTEDVRPVFWRNRNSSYVARTQTWDEYPNGRWTDSRSPAFGELDAYG-VGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ + W P ++ I DI+V
Sbjct: 368 TNEQNIKLWGEPKSVKDISDIFV 390
>J3K5S4_COCIM (tr|J3K5S4) Methylenetetrahydrofolate reductase OS=Coccidioides
immitis (strain RS) GN=CIMG_08202 PE=3 SV=1
Length = 629
Score = 369 bits (947), Expect = 1e-99, Method: Compositional matrix adjust.
Identities = 183/391 (46%), Positives = 255/391 (65%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM P+F DITWGAGG +D+T E+ N Q++
Sbjct: 15 RPSISFEFFPPKTAQGVQNLYDRMDRMHGLGPAFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ G N+LALRGDPP ++ + TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDWALQCAHKAGCTNILALRGDPPREKESWAPTEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE G E + + +LK KVDAG I+TQ+
Sbjct: 135 VKYIREKYGNHFDIGVAGYPE---------GCEDEEDPETLMKHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIFL +V C + GI PI+PGIMPI+ Y F+R + + K K+P M ALEP+K+
Sbjct: 186 FYDVDIFLDWVKRCRENGIQVPILPGIMPISTYASFLRRSNWVKCKVPESWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSL 314
++ AVK G L MC+KIL GI+ LH YT+N+ ++ +L L LI E+ + + L
Sbjct: 246 DDAAVKQIGKKLVANMCQKILDSGIRHLHFYTMNLAQATKMVLEELKLIPSYETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRQSLGLGRRDEDVRPIFWRHRHQSYVARTQTWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+D+ + + +L+
Sbjct: 365 LKGTNEQNIKLWGEP-KSIKDLSAIFIRFLE 394
>M9M1W1_9BASI (tr|M9M1W1) 5,10-methylenetetrahydrofolate reductase OS=Pseudozyma
antarctica T-34 GN=PANT_27c00063 PE=4 SV=1
Length = 652
Score = 369 bits (946), Expect = 2e-99, Method: Compositional matrix adjust.
Identities = 179/393 (45%), Positives = 252/393 (64%), Gaps = 15/393 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R+ +SFE+FPP+T G+ NL++R++RM P F DITW AGG T+D+T + + +
Sbjct: 32 RIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGRTSDLTASLVKTVHTYI 91
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP +KID AL+ K G +N+LALRGDPP GQ ++ GF A++L
Sbjct: 92 GLETCMHLTCTNMPRDKIDTALKEAKEFGCRNILALRGDPPAGQSEWEPHAAGFTQAQEL 151
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR +YGDYF I VAG+PE HP+A+ + + EL LKSK+DAGAD I TQ+
Sbjct: 152 VEYIRQQYGDYFAIAVAGFPEGHPEAV--------DGPEKELERLKSKIDAGADFIFTQM 203
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIF K+V D GITCPI+PG+MPI Y GF R T T +P AL+P+KD
Sbjct: 204 FYDFDIFAKWVKDVRAAGITCPIIPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVKD 263
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
+++ V+ G L +MC+KI+ GI LH+YT+N+EK + +L LGL L
Sbjct: 264 DDQKVREIGTRLVGDMCKKIVGTGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPL 323
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PW R E +RPIFWANR KSY++RT WD++P+GRWGD+ +P+YG + Y ++
Sbjct: 324 PWTPSLTPKRRDEKIRPIFWANRAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VK 382
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
R + + E W P +S++D+ L+ ++C
Sbjct: 383 LRYSNDEAKEMWGTP-QSLDDVKA---LFQRFC 411
>C1G7L7_PARBD (tr|C1G7L7) Methylenetetrahydrofolate reductase OS=Paracoccidioides
brasiliensis (strain Pb18) GN=PADG_03172 PE=3 SV=1
Length = 629
Score = 369 bits (946), Expect = 2e-99, Method: Compositional matrix adjust.
Identities = 180/383 (46%), Positives = 253/383 (66%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++ +E
Sbjct: 18 ISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++K+ TEGGF A+DLVK+
Sbjct: 78 TCMHLTCTDMPSEKVDAALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++F I VAGYPE G + + + +LK KVDAG I+TQ+FYD
Sbjct: 138 IRDKYGNHFDIGVAGYPE---------GCEDQDDPELLMQHLKEKVDAGGTFIITQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL +V C GI PI+PGIMPI+ Y FIR + + K +IP + ALEP+K+++
Sbjct: 189 VDNFLAWVKKCRDKGIKVPIIPGIMPIHTYAAFIRRSNWTKIQIPPGWLEALEPVKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MC+K+LA GI LH YT+N++++ +L LGLI E+ + + LPWR
Sbjct: 249 AVRNLGKSLVANMCKKMLASGIHHLHFYTMNLQQATKMVLDELGLIPSHETPLQKPLPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y + +
Sbjct: 309 QSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ + W P L+ + +I++
Sbjct: 368 TNEQNIQLWGKPKSLKELSEIFI 390
>C0RZ73_PARBP (tr|C0RZ73) Methylenetetrahydrofolate reductase OS=Paracoccidioides
brasiliensis (strain Pb03) GN=PABG_00728 PE=3 SV=1
Length = 629
Score = 369 bits (946), Expect = 2e-99, Method: Compositional matrix adjust.
Identities = 180/383 (46%), Positives = 253/383 (66%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++ +E
Sbjct: 18 ISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++K+ TEGGF A+DLVK+
Sbjct: 78 TCMHLTCTDMPSEKVDAALQSAFKAGCTNILALRGDPPREKEKWEATEGGFRYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++F I VAGYPE G + + + +LK KVDAG I+TQ+FYD
Sbjct: 138 IRDKYGNHFDIGVAGYPE---------GCEDQDDPELLMQHLKEKVDAGGTFIITQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL +V C GI PI+PGIMPI+ Y FIR + + K +IP + ALEP+K+++
Sbjct: 189 VDNFLAWVKKCRDNGIKVPIIPGIMPIHTYAAFIRRSNWTKIQIPPGWLEALEPVKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MC+K+LA GI LH YT+N++++ +L LGLI E+ + + LPWR
Sbjct: 249 AVRNLGKSLVANMCKKMLASGIHHLHFYTMNLQQATKMVLDELGLIPSHETPLQKPLPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y + +
Sbjct: 309 QSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ + W P L+ + +I++
Sbjct: 368 TNEQNIQLWGKPKSLKELSEIFI 390
>Q5B0P7_EMENI (tr|Q5B0P7) Methylenetetrahydrofolate reductase OS=Emericella
nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 /
NRRL 194 / M139) GN=AN5883.2 PE=3 SV=1
Length = 627
Score = 368 bits (944), Expect = 2e-99, Method: Compositional matrix adjust.
Identities = 184/386 (47%), Positives = 249/386 (64%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
++ SFEFFPPKT GV NL++RMDRM PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 KIGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP E++D ALQ G N+LALRGDPP ++ + +GGF A+DL
Sbjct: 75 GLETCMHLTCTDMPQERVDAALQAAYKAGCTNILALRGDPPREKEVWEAADGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ IVTQ+
Sbjct: 135 VKYIREKYGNHFCIGVGGYPEGADDNSDVDQL---------IDHLKEKVDAGSSFIVTQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+K+V C GI PI+PGIMPI Y FIR + KT IP + + ALEP+K+
Sbjct: 186 FYDTDNFIKWVEKCRAKGINVPIIPGIMPIQTYAAFIRRANWTKTHIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +MCR+++A GIK LH YT+N+ +S +L L L E+ I R L
Sbjct: 246 DDAAVKQVGKRLIADMCRRLIASGIKHLHFYTMNLAQSTQLVLEELELTPTAEAPIPRPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRREEDVRPIFWRNRNSSYIARTAIWDEFPNGRWTDSRSPAFGELELYG-VG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P LR + +++V
Sbjct: 365 LKGTNEQNIKLWGEPNSLRDLAEVFV 390
>Q0GA67_EMEND (tr|Q0GA67) Methylenetetrahydrofolate reductase OS=Emericella
nidulans GN=metF PE=3 SV=1
Length = 627
Score = 368 bits (944), Expect = 2e-99, Method: Compositional matrix adjust.
Identities = 184/386 (47%), Positives = 249/386 (64%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
++ SFEFFPPKT GV NL++RMDRM PSF DITWGAGG +D+T E+ N Q++
Sbjct: 15 KIGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLSDLTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP E++D ALQ G N+LALRGDPP ++ + +GGF A+DL
Sbjct: 75 GLETCMHLTCTDMPQERVDAALQAAYKAGCTNILALRGDPPREKEVWEAADGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ IVTQ+
Sbjct: 135 VKYIREKYGNHFCIGVGGYPEGADDNSDVDQL---------IDHLKEKVDAGSSFIVTQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYDTD F+K+V C GI PI+PGIMPI Y FIR + KT IP + + ALEP+K+
Sbjct: 186 FYDTDNFIKWVEKCRAKGINVPIIPGIMPIQTYAAFIRRANWTKTHIPPDWLEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L +MCR+++A GIK LH YT+N+ +S +L L L E+ I R L
Sbjct: 246 DDAAVKQVGKRLIADMCRRLIASGIKHLHFYTMNLAQSTQLVLEELELTPTAEAPIPRPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR + R EDVRPIFW NR SYI+RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRPSLGLNRREEDVRPIFWRNRNSSYIARTAIWDEFPNGRWTDSRSPAFGELELYG-VG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P LR + +++V
Sbjct: 365 LKGTNEQNIKLWGEPNSLRDLAEVFV 390
>I4YIV3_WALSC (tr|I4YIV3) Methylenetetrahydrofolate reductase OS=Wallemia sebi
(strain ATCC MYA-4683 / CBS 633.66) GN=WALSEDRAFT_66783
PE=3 SV=1
Length = 600
Score = 367 bits (943), Expect = 3e-99, Method: Compositional matrix adjust.
Identities = 192/417 (46%), Positives = 259/417 (62%), Gaps = 23/417 (5%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ EK+ D R+ +SFEFFPP+T G+ NL +R++RM P F DITW +GG
Sbjct: 1 MKITEKLLAAERED--RLWWSFEFFPPRTAQGMTNLVDRIERMRRLGPEFVDITWHSGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TA++T E+ Q + VET +HLTCT MP EK+ NAL+ K NG NVLALRGDPP GQ
Sbjct: 59 TAELTTELVKTCQASIGVETCMHLTCTGMPREKVINALEEAKKNGCTNVLALRGDPPRGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
++ GF A DLV+HIR +YGDYF + VAG+PE G+ + NE+ Y
Sbjct: 119 TEWYPHPNGFTYAADLVRHIRQEYGDYFEVAVAGFPE------GNLQYKHSSDKDNEIQY 172
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGADLI+TQ+FYD D F+ + N + G+T PIVPGIMPI + GF + +
Sbjct: 173 LKEKVDAGADLIMTQMFYDVDNFIDWCNKVREAGVTVPIVPGIMPIQTWNGFQKAVQMAQ 232
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
TK+P + M LE +K+++ V+ G L ++MCRKIL GI+ LHLYT+N+E+ I
Sbjct: 233 TKVPQDWMDQLEAVKEDDAKVREVGTKLVSDMCRKILDANVGIRGLHLYTMNLERGPKMI 292
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L LI +++I LPWR R E++RPIFWANR KSY+SRT WD++P+GRWGD
Sbjct: 293 LQELNLIPQTQILNPLPWRPSLTPTRRAENIRPIFWANRQKSYLSRTEMWDEFPNGRWGD 352
Query: 359 SGNPSYGALTDY----QFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
S +P+YG + + F AR E W PL+ + V L+ ++C + L
Sbjct: 353 SRSPAYGEIDGWGPTINFKLDEAR-----EIWGEPLKYDD----VCNLFSRFCLNDL 400
>M2R3N4_CERSU (tr|M2R3N4) Methylenetetrahydrofolate reductase OS=Ceriporiopsis
subvermispora B GN=CERSUDRAFT_112818 PE=3 SV=1
Length = 605
Score = 367 bits (943), Expect = 3e-99, Method: Compositional matrix adjust.
Identities = 183/413 (44%), Positives = 257/413 (62%), Gaps = 17/413 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
M++ +K+ D RV +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MRISKKIEAAQKED--RVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFVDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T E+ Q+++ +ET +HLTCTNMP EK+D AL+ K NG +NVLALRGDPP G+
Sbjct: 59 TSELTSELVKTCQSLIGIETCMHLTCTNMPKEKVDIALREAKQNGCRNVLALRGDPPMGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ EGGF+ DLV+HIR +YGDYF I VAG+P+ E E+ Y
Sbjct: 119 DEWEAVEGGFSHGIDLVRHIRKEYGDYFDIAVAGFPQ--------HVTLPPEERDLEMKY 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+D GA+ I TQ+FYD +IF+K+V GIT PIVPGI PI + GF++ T
Sbjct: 171 LKEKIDGGANFIFTQMFYDVEIFIKWVRAVRAAGITVPIVPGIAPIQTFNGFMKSTVLSG 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T IP + ALEP K+N+E V+ G L +MCR+IL GI+ LH YT+N+E+ +
Sbjct: 231 TTIPQATLDALEPYKNNDEKVREIGTKLVADMCRRILKEDIGIRGLHFYTMNLERGTRML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR R E +RPIFWANRP+SY+ RT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRVETVKPLPWRPSLTPNRRSESIRPIFWANRPRSYVHRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
S +P+YG L Y + +++ + + W P + E + L+ ++C L
Sbjct: 351 SRSPAYGELDGYGVWIKQTKEEAV-KLWDTPTTAQE----IHELFKKFCLGQL 398
>R9P122_9BASI (tr|R9P122) Methylenetetrahydrofolate reductase OS=Pseudozyma
hubeiensis SY62 GN=PHSY_002365 PE=4 SV=1
Length = 651
Score = 367 bits (943), Expect = 3e-99, Method: Compositional matrix adjust.
Identities = 182/393 (46%), Positives = 250/393 (63%), Gaps = 15/393 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R+ +SFE+FPP+T G+ NL++R++RM P F DITW AGG T+D+T + + +
Sbjct: 31 RIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGRTSDLTASLVKTVHTYI 90
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP EKID AL+ K G +N+LALRGDPP GQ ++ GF+ A++L
Sbjct: 91 GLETCMHLTCTNMPREKIDTALKEAKEFGCRNILALRGDPPAGQSEWEPHAAGFSRAKEL 150
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR +YGDYF I VAG+PE HP+A+ DG EL LK K+DAGAD I TQ+
Sbjct: 151 VEYIREQYGDYFAIAVAGFPEGHPEAV--DGADL------ELQRLKEKIDAGADFIFTQM 202
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIF K+V D GI CPI+PG+MPI Y GF R T T +P AL+P+KD
Sbjct: 203 FYDFDIFAKWVKDVRAAGINCPIIPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVKD 262
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
+++ V+ G L EMC+KI+ GI LH+YT+N+EK + +L LGL L
Sbjct: 263 DDQKVREIGTRLVGEMCKKIVGTGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPL 322
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PW R E +RPIFWANR KSY++RT WD++P+GRWGD+ +P+YG + Y ++
Sbjct: 323 PWTPSLTPKRRDEKIRPIFWANRAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VK 381
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
R + + E W P S++D V L+ ++C
Sbjct: 382 LRYSNDEAKEMWGTPT-SLQD---VKALFQKFC 410
>J3Q094_PUCT1 (tr|J3Q094) Methylenetetrahydrofolate reductase OS=Puccinia
triticina (isolate 1-1 / race 1 (BBBD)) GN=PTTG_04810
PE=3 SV=1
Length = 643
Score = 366 bits (940), Expect = 8e-99, Method: Compositional matrix adjust.
Identities = 185/409 (45%), Positives = 256/409 (62%), Gaps = 16/409 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K+ +R+ +SFE+FPPKT++G+ NL++R+ RM P F DITWGAGGS
Sbjct: 1 MKISQKL--AAAESENRISWSFEYFPPKTDNGLTNLYDRIYRMSQLGPIFIDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T E +ET +HLTCTNMP E+ID AL+ G +N+LALRGDPP G
Sbjct: 59 TSNLTTEFVKTAHEQFGLETCMHLTCTNMPKERIDTALREAYEFGCENILALRGDPPKGS 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
++ TEGGF A DLV+HIRA+YGD+F I VAG+PE H + ++ + + E Y
Sbjct: 119 SEWTATEGGFEHAIDLVRHIRAQYGDHFDIAVAGFPEGH--------MHSSLSREQETIY 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGA+ I TQ+FYD DIF+ +V + GIT P++PG+MPI ++ F R+T F K
Sbjct: 171 LKEKIDAGANFIFTQMFYDVDIFIDWVREIRAAGITVPVIPGLMPIQSWAQFKRVTNFSK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T +P + LEPI+ +++AV+ G L +MCRKIL GI+ LH YT+N+E+ I
Sbjct: 231 TIVPQYFLDKLEPIQSDDQAVREAGTKLVADMCRKILNSDLGIRILHFYTMNLERGTKMI 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L I+ LPW+ R E +RPIFWANR KSY+SRT WD++P+GRWGD
Sbjct: 291 LDELNLNPSRDITNPLPWKMSLLGKRRSESIRPIFWANRAKSYLSRTETWDEFPNGRWGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
S +P+YG L Y A + L P S+ED+ ++ YC
Sbjct: 351 SRSPAYGELDGYGININSATIETLKGLKKFPT-SLEDL---ARIFANYC 395
>Q6CG63_YARLI (tr|Q6CG63) Methylenetetrahydrofolate reductase OS=Yarrowia
lipolytica (strain CLIB 122 / E 150) GN=YALI0B00572g
PE=3 SV=1
Length = 583
Score = 366 bits (939), Expect = 9e-99, Method: Compositional matrix adjust.
Identities = 183/405 (45%), Positives = 256/405 (63%), Gaps = 13/405 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ K+ D FSFEFF PKT GV+NL++RMDRM P F DITW AGG
Sbjct: 1 MKISHKLEKAHAAD-STPTFSFEFFVPKTSQGVNNLYDRMDRMYQLGPQFIDITWNAGGR 59
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+++T E+ Q+ + +ET +HLTCT MP + ++NALQ+ G QN+LALRGDPP
Sbjct: 60 LSNLTNEMVATAQSALGLETCMHLTCTGMPKQLVENALQSAFDGGCQNILALRGDPPVES 119
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+K+ +GGF A+DLVK+I++KYGDYF I VA YPE P+ D + + +
Sbjct: 120 EKWEAVDGGFRYAKDLVKYIKSKYGDYFDIGVAAYPEGTPEEPDVDIL---------IDH 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG IVTQ+FYDTD FLK+V+ C GI PI+PGIMPI+ Y F+R +C+
Sbjct: 171 LKEKVDAGGTFIVTQMFYDTDNFLKWVDKCRAKGINVPIIPGIMPISTYASFMRRANWCQ 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAIL 299
+IP + + LEP+KD++ V+ G L +MC+K+L G IK LH YT+N+EK+ + +L
Sbjct: 231 IQIPQDFLDQLEPVKDDDMRVRELGTQLVADMCQKMLDSGKIKHLHFYTMNLEKATVMVL 290
Query: 300 TSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS 359
L L + LPWR + R E VRPIFW NR +SY++RT WD++P+GRWGDS
Sbjct: 291 ERLNLPAQDSAVAPLPWRPSLALGRQDETVRPIFWKNRKQSYVARTQDWDEFPNGRWGDS 350
Query: 360 GNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P++G L Y + R +K+ E W P ++++D+ + + YL
Sbjct: 351 RSPAFGELETYGVLL-RQSPQKVLELWGEP-KTVDDLKTLLVNYL 393
>Q6FU20_CANGA (tr|Q6FU20) Methylenetetrahydrofolate reductase OS=Candida glabrata
(strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
NRRL Y-65) GN=CAGL0F07029g PE=3 SV=1
Length = 600
Score = 365 bits (938), Expect = 1e-98, Method: Compositional matrix adjust.
Identities = 189/415 (45%), Positives = 268/415 (64%), Gaps = 21/415 (5%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ +K+ PD+ FSFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITQKLADRHKEKPDKATFSFEYFVPKTTQGVQNLYDRMDRMYEASLPEFIDITWNAGG 60
Query: 60 ST-ADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPP- 117
+ ++ E+ Q+++ +ET +HLTCTNMP+ +ID AL+ ++G QN+LALRGDPP
Sbjct: 61 GRLSQLSTELVATAQSVLGLETCMHLTCTNMPISQIDEALEDAYNSGCQNILALRGDPPL 120
Query: 118 HGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNE 177
+ + + EGGF A+DLVK+IRAKYGD+F I VAGYPE HP+ + +
Sbjct: 121 NAPNGWQPIEGGFNYAKDLVKYIRAKYGDHFDIGVAGYPEGHPEE---------KERHKD 171
Query: 178 LTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTG 237
L YLK K+DAG I+TQ+FYD D F+++ ++ ++GI PI+PGIMPI Y F+R
Sbjct: 172 LVYLKEKIDAGGSFIITQMFYDVDNFIQWCHEVREMGIDVPIIPGIMPITTYAAFLRRAQ 231
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSAL 296
+ + KIP + LEP+KD+++ V+ G L +MC+KIL G +K LH+YT+N+EK+ L
Sbjct: 232 WGQIKIPQAFLDVLEPVKDDDQLVRDKGSELIVDMCQKILNSGYVKHLHIYTMNLEKAPL 291
Query: 297 AILTSLGLI-EESKIS----RSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--D 349
IL LGL+ ES+++ SLPWR+ N R E+VRPIFW RP SY++RT W D
Sbjct: 292 IILEKLGLLPSESEVNANPLASLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAMD 351
Query: 350 QYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++P+GR+GDS +P++G L R KK E W+ P ++IED+ + + YL
Sbjct: 352 EFPNGRFGDSSSPAFGDLDLCGSTLIRQSGKKSLELWSTP-KTIEDVSQLVISYL 405
>Q4P5K1_USTMA (tr|Q4P5K1) Methylenetetrahydrofolate reductase OS=Ustilago maydis
(strain 521 / FGSC 9021) GN=UM04612.1 PE=3 SV=1
Length = 650
Score = 365 bits (936), Expect = 2e-98, Method: Compositional matrix adjust.
Identities = 181/393 (46%), Positives = 250/393 (63%), Gaps = 15/393 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R+ +SFE+FPP+T G+ NL++R++RM P F DITW AGG T+D+T + + +
Sbjct: 31 RIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGRTSDLTASLVKTVHTYI 90
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP EKID AL+ K G +N+LALRGDPP GQ ++ GF A++L
Sbjct: 91 GLETCMHLTCTNMPREKIDTALKEAKEFGCRNILALRGDPPAGQSEWEPHAAGFTRAKEL 150
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR +YGDYF I VAG+PE HP+AI DG + EL LK K++AGAD I TQ+
Sbjct: 151 VEYIREQYGDYFAIAVAGFPEGHPEAI--DGP------ELELERLKEKIEAGADFIFTQM 202
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIF K+V D GI CPI+PG+MPI Y GF R T T +P AL+P++D
Sbjct: 203 FYDFDIFAKWVKDVRAAGINCPIIPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVRD 262
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
+++ V+ G L EMC+KI+ GI LH+YT+N+EK + +L LGL L
Sbjct: 263 DDQKVREIGTRLVGEMCKKIVGTGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPL 322
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PW R E +RPIFWANR KSY++RT WD++P+GRWGD+ +P+YG + Y ++
Sbjct: 323 PWTPSLTPKRREEKIRPIFWANRAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VK 381
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
R +++ E W P ++D V L+ Q+C
Sbjct: 382 LRYSNEEAKEMWGAPT-CLDD---VKTLFQQFC 410
>F8Q5A5_SERL3 (tr|F8Q5A5) Methylenetetrahydrofolate reductase OS=Serpula
lacrymans var. lacrymans (strain S7.3)
GN=SERLA73DRAFT_161762 PE=3 SV=1
Length = 605
Score = 364 bits (934), Expect = 4e-98, Method: Compositional matrix adjust.
Identities = 180/393 (45%), Positives = 248/393 (63%), Gaps = 15/393 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
+V +SFE+FPP+T G+ NL +R++RM A P F DITW AGG T+D+T E+ Q ++
Sbjct: 15 KVWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGRTSDLTSEMVKTCQGLI 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP EK+D AL+ K +G +NVLALRGDPP G+D++ EGGF DL
Sbjct: 75 GMETCMHLTCTNMPKEKVDIALREAKQHGCRNVLALRGDPPQGKDEWEAVEGGFVHGIDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V+HI +YGDYF I VAG+P+ + + E E+ YLK KVD G D I TQ+
Sbjct: 135 VRHIHNEYGDYFDIAVAGFPQ--------NQLLPPEERDLEMKYLKEKVDEGVDFIFTQM 186
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD ++F+ +V GIT PIVPGI PI + GF+R T KT+IP M ALEP K+
Sbjct: 187 FYDVEVFIDWVKAVRVAGITIPIVPGIAPIQTWNGFMRATSLAKTQIPQSFMEALEPHKN 246
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
++E V+ G L EMC +IL GI+ LH YT+N+EK +L L L+ + + L
Sbjct: 247 DDEKVREIGTKLVAEMCLRILKEDIGIRGLHFYTMNLEKGTKMLLEELNLVPRVETIKPL 306
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ R +E++RPIFWANR KSY+SRT WD+YP+GR+GDS +P+YG L Y
Sbjct: 307 PWRQSLTPNRRQENIRPIFWANRTKSYLSRTENWDEYPNGRFGDSRSPAYGELDGYGVWI 366
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+ ++ + + W P E + L+ ++C
Sbjct: 367 KQTKEDAM-KLWGQPTTFNE----ITTLFSRFC 394
>E7RAA3_PICAD (tr|E7RAA3) Methylenetetrahydrofolate reductase OS=Pichia angusta
(strain ATCC 26012 / NRRL Y-7560 / DL-1) GN=HPODL_3526
PE=3 SV=1
Length = 598
Score = 363 bits (932), Expect = 7e-98, Method: Compositional matrix adjust.
Identities = 185/406 (45%), Positives = 252/406 (62%), Gaps = 15/406 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV K+ + FSFEFF PKT G+ NL++RMDRM NP F DITW AGG
Sbjct: 1 MKVTNKLLESHKEENAPATFSFEFFTPKTSQGLQNLYDRMDRMYDLNPLFIDITWNAGGR 60
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
+ +T E+ ++ +ET +HLTCTNM + ID AL++ +G QN+LALRGDPP
Sbjct: 61 LSTLTTEMVQTTSTVLGLETCMHLTCTNMKTDLIDQALRSAYESGCQNILALRGDPPLDG 120
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
++ G F A+DL+++IR YGD+F I VA YPE HP+ SD V T L Y
Sbjct: 121 S---ESTGDFKYAKDLIRYIRKHYGDHFCIGVAAYPEGHPEE--SDPVKT-------LKY 168
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAGAD IVTQ+FYDT+ F+ + ++C +IGIT PI+PGIMPI+ Y FIR G+ +
Sbjct: 169 LKEKQDAGADFIVTQMFYDTENFINWCDECRKIGITMPIIPGIMPISTYAAFIRRAGWSE 228
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKIL-AHGIKTLHLYTLNMEKSALAIL 299
IP ALEPIKD++ V+ G L EMC+++L + + LH YT+N+EKS L IL
Sbjct: 229 IAIPKHFSEALEPIKDDDAKVREVGTKLVIEMCQQLLESKRVNHLHFYTMNLEKSTLMIL 288
Query: 300 TSLGLIEESKI-SRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L+ + ++ PWR+ N R +E VRPIFW NR SYISRT WD++P+GRWGD
Sbjct: 289 QGLNLVTKQQLHDMKQPWRKSLNPNRSKETVRPIFWKNRKFSYISRTANWDEFPNGRWGD 348
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
S +P++ ++ + R KK E W P S++D+ + + Y+
Sbjct: 349 SRSPAFASVESCESELIRHSPKKALELWGTP-NSLKDLAELTMRYI 393
>J9MTN4_FUSO4 (tr|J9MTN4) Methylenetetrahydrofolate reductase OS=Fusarium
oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 /
FGSC 9935 / NRRL 34936) GN=FOXG_06273 PE=3 SV=1
Length = 616
Score = 363 bits (931), Expect = 9e-98, Method: Compositional matrix adjust.
Identities = 183/388 (47%), Positives = 246/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 13 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 72
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 73 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWTAADGGFQYARDLVKH 132
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 133 IRDTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGASFIVTQMFYD 183
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 184 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 243
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MCRK+LA+GI LH YT+N+ ++ +L L E + ++LPW+
Sbjct: 244 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEELQWAPCAERPLQQALPWK 303
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y
Sbjct: 304 QSKGLGRREEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGT 363
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ ++W P ++I+DI + + YLQ
Sbjct: 364 NEAN-RKKWGEP-KTIQDIAQLFVRYLQ 389
>F9FK60_FUSOF (tr|F9FK60) Methylenetetrahydrofolate reductase OS=Fusarium
oxysporum (strain Fo5176) GN=FOXB_06789 PE=3 SV=1
Length = 621
Score = 363 bits (931), Expect = 9e-98, Method: Compositional matrix adjust.
Identities = 183/388 (47%), Positives = 246/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWTAADGGFQYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRDTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 189 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MCRK+LA+GI LH YT+N+ ++ +L L E + ++LPW+
Sbjct: 249 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEELQWAPCAERPLQQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y
Sbjct: 309 QSKGLGRREEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGT 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ ++W P ++I+DI + + YLQ
Sbjct: 369 NEAN-RKKWGEP-KTIQDIAQLFVRYLQ 394
>C5E2N6_LACTC (tr|C5E2N6) Methylenetetrahydrofolate reductase OS=Lachancea
thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL
Y-8284) GN=KLTH0H06446g PE=3 SV=1
Length = 599
Score = 362 bits (930), Expect = 1e-97, Method: Compositional matrix adjust.
Identities = 183/414 (44%), Positives = 259/414 (62%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXD-PDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGG 59
M+V EK++ + + FSFEFF PKT GV NL++RMDRM +P F DITW AGG
Sbjct: 1 MRVSEKLQKNREANGTSKATFSFEFFVPKTSQGVQNLYDRMDRMYQTHPQFIDITWNAGG 60
Query: 60 STADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHG 119
+ ++ E+ + Q+++ +ET +HLTCTNMP + ID+ALQ +G QN+LALRGD P
Sbjct: 61 RLSQLSTELVSTSQSVLGLETCMHLTCTNMPRQLIDDALQKAYESGCQNILALRGDAPIT 120
Query: 120 QDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELT 179
++ EGGF A+DLV++IR KYGD+F I VAGYPE HP+ EA +
Sbjct: 121 SSEWKPCEGGFTYAKDLVRYIREKYGDHFDIGVAGYPEGHPEE---------EASPKLVQ 171
Query: 180 YLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK KVDAGAD I+TQ+FYD D F+++ GI PI+PGIMPI Y F+R + +C
Sbjct: 172 YLKEKVDAGADFIITQMFYDADNFIEWCRQVRAAGIEVPIIPGIMPITTYAAFLRRSSWC 231
Query: 240 KTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKT-LHLYTLNMEKSALAI 298
+ +P MA L+P+KD+++AV+ G L +MC+K+L G T LH+YT+N+EK+ + +
Sbjct: 232 QINVPEAFMAKLDPVKDDDQAVREVGTELVAQMCQKLLDSGYVTHLHMYTMNLEKACIMV 291
Query: 299 LTSLGLI-EESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQY 351
L LGL+ E+ I R +PWR+ + R E VRPIFW RP SY++RT W D++
Sbjct: 292 LDRLGLLSEDEDIFRDEVVPMPWRKSLHPQRRNESVRPIFWQKRPYSYVARTSQWTADEF 351
Query: 352 PHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
P+GR+GDS +P++G L R ++ E W+ P + DI + + YL
Sbjct: 352 PNGRFGDSSSPAFGDLDLLGSTSIRQSPQRALELWSTPTK-FSDIAALVIDYLH 404
>E3JWM7_PUCGT (tr|E3JWM7) Methylenetetrahydrofolate reductase OS=Puccinia
graminis f. sp. tritici (strain CRL 75-36-700-3 / race
SCCL) GN=PGTG_02893 PE=3 SV=1
Length = 644
Score = 362 bits (929), Expect = 1e-97, Method: Compositional matrix adjust.
Identities = 176/372 (47%), Positives = 242/372 (65%), Gaps = 12/372 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K+ +R+ +SFE+FPPKT++G+ NL++R+ RM P F DITWGAGGS
Sbjct: 1 MKISQKL--AAAESENRISWSFEYFPPKTDNGLTNLYDRICRMSQLGPIFIDITWGAGGS 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T E +ET +HLTCTNMP KID AL+ G +N+LALRGDPP G
Sbjct: 59 TSNLTTEFVKTAHEQFGLETCMHLTCTNMPKSKIDTALKEAYEFGCENILALRGDPPKGS 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
++ TEGGF A DLV+HIRA+YGD+F I VAG+PE H + +T + + + Y
Sbjct: 119 TEWTATEGGFEHAIDLVRHIRAEYGDHFDIAVAGFPEGH--------MHSTLSREQQTIY 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K++AGA+ I TQ+FYD DIF+ +V + GIT P++PG+MPI ++ F R+T F K
Sbjct: 171 LKEKIEAGANFIFTQMFYDVDIFIDWVREIRAAGITVPVIPGLMPIQSWAQFKRVTNFSK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T +P + LEPI+ +++AV+ G L +MCRKIL GI+ LH YT+N+E+ I
Sbjct: 231 TIVPQYFLDKLEPIQSDDQAVREAGTKLVADMCRKILNSDLGIRILHFYTMNLERGTKMI 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L I+ LPW+ R E +RPIFWANR KSY+SRT WD++P+GRWGD
Sbjct: 291 LDELNLNPSRDITNPLPWKMSLLGKRRSESIRPIFWANRAKSYLSRTETWDEFPNGRWGD 350
Query: 359 SGNPSYGALTDY 370
S +P+YG L Y
Sbjct: 351 SRSPAYGELDGY 362
>B0CU22_LACBS (tr|B0CU22) Methylenetetrahydrofolate reductase OS=Laccaria bicolor
(strain S238N-H82 / ATCC MYA-4686) GN=LACBIDRAFT_182479
PE=3 SV=1
Length = 602
Score = 362 bits (929), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 178/372 (47%), Positives = 240/372 (64%), Gaps = 12/372 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K++ + D++ +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MKITQKIQQSA--NNDKIWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+T E+ Q ++ +ET +HLTCTNMP EK+D AL+ K +G +NVLALRGDPP G+
Sbjct: 59 TSDLTSEMVKTCQGLIGMETCMHLTCTNMPKEKVDIALREAKQHGCRNVLALRGDPPSGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
D++ EGGF DLV+HIR YGDYF I VAG+P+ A+ D E+ +
Sbjct: 119 DEWEAVEGGFVHGIDLVRHIRRDYGDYFDIAVAGFPQHM--ALPPD------ERDQEIQW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAG I TQ+FYD +F+ +V GIT PIVPGI PI + GF R T K
Sbjct: 171 LKEKVDAGVAFIFTQMFYDVQLFIDWVKAIRAAGITIPIVPGIAPIQTWNGFQRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
+P + ALEPIK+++E V+ G L +MCR+IL GI+ LH YT+N+EK +
Sbjct: 231 IVVPQSFLDALEPIKNDDEKVREVGTRLVADMCRRILKEDIGIRGLHFYTMNLEKGTKML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R +E +RPIFWANR KSYISRT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRIETIKPLPWRQSLTPNRRQESIRPIFWANRTKSYISRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDY 370
S +P+YG L Y
Sbjct: 351 SRSPAYGELDGY 362
>F4RGV4_MELLP (tr|F4RGV4) Methylenetetrahydrofolate reductase OS=Melampsora
larici-populina (strain 98AG31 / pathotype 3-4-7)
GN=MELLADRAFT_42930 PE=3 SV=1
Length = 646
Score = 362 bits (928), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 175/372 (47%), Positives = 240/372 (64%), Gaps = 12/372 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K+ RV +SFE+FPPKT++GV NL++R++RM P F DITWGAGG+
Sbjct: 1 MKISQKLAAAEAEG--RVSWSFEYFPPKTDNGVANLYDRIERMSQLGPIFIDITWGAGGT 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T E +ET +HLTCTNMP E+ID+AL+ +G +N+LALRGDPP G
Sbjct: 59 TSNLTTEFVKTAHRQFGLETCMHLTCTNMPQEQIDSALKEAYDSGCENILALRGDPPRGS 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
++ TEGGF A DL++HIR+ YGD+F I VAG+PE D E Y
Sbjct: 119 SEWTATEGGFTHAVDLLRHIRSTYGDHFDIAVAGFPEGPTDP--------NLTRLQETMY 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAGA I TQ+FYD D+F+ +V + GI P++PGIMPI ++ F R+T F K
Sbjct: 171 LKEKIDAGASFIFTQMFYDVDVFIDWVRELRAAGIKVPVIPGIMPIQSWAQFKRITTFHK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T +P ++ LEPI+++++AV+ G L +MCRKIL GIK LH YT+N+E+ I
Sbjct: 231 TAVPPSFLSQLEPIQNDDQAVREVGTRLIADMCRKILDSDLGIKILHFYTMNLERGTKMI 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L + I+ LPWR + R E +RPIFWANR KSY++RT WD++P+GRWGD
Sbjct: 291 LDELEMSPYRDITNPLPWRLSLSGKRRTESIRPIFWANRTKSYLTRTETWDEFPNGRWGD 350
Query: 359 SGNPSYGALTDY 370
S +P+YG L Y
Sbjct: 351 SRSPAYGELDGY 362
>N1J4Z8_ERYGR (tr|N1J4Z8) Methylenetetrahydrofolate reductase OS=Blumeria
graminis f. sp. hordei DH14 GN=BGHDH14_bgh00637 PE=4
SV=1
Length = 625
Score = 362 bits (928), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 189/389 (48%), Positives = 251/389 (64%), Gaps = 14/389 (3%)
Query: 19 VFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCV 78
FSFEFFPPKT GV NL++RMDRM PSF DITWGAGG+ A +T+E+ + Q+ +
Sbjct: 17 TFSFEFFPPKTTQGVQNLYDRMDRMHGLGPSFIDITWGAGGNIAQLTVEMVSVAQSQYGL 76
Query: 79 ETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVK 138
ET +HLTCT+M +EK+D AL+ G N+LALRGDPP Q+K+ T+GGF A+DLVK
Sbjct: 77 ETCMHLTCTDMGLEKVDKALKDAYKAGCTNILALRGDPPREQEKWTATDGGFHYAKDLVK 136
Query: 139 HIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFY 198
HIRA YGD+F I VAGYPE G D E L +LK KV+AG IVTQ+FY
Sbjct: 137 HIRATYGDHFDIGVAGYPE------GCDDQDDPELL---LDHLKEKVEAGGTFIVTQMFY 187
Query: 199 DTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNE 258
D + FL++V GI PI+PGIMPIN Y F+R KIP + ALE IK+++
Sbjct: 188 DVENFLEWVGKVRAKGINVPIIPGIMPINTYASFLRRCNHMGCKIPPKWATALEGIKNDD 247
Query: 259 EAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLP 315
AV+ G L EMCRKILA G I LH YT+N+ ++ +L LGL EE + ++LP
Sbjct: 248 AAVRSIGTGLVAEMCRKILASGLIHHLHFYTMNLAQATRMVLDQLGLTPSEERPLKQALP 307
Query: 316 WRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRP 375
WR+ ++ R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 308 WRQSLSLGRRDEDVRPIFWKNRNKSYVTRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGL 366
Query: 376 RARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+ +++ + W P I+D+ + + YL
Sbjct: 367 KGSNQQNRKLWGEP-ECIKDVAEIFVKYL 394
>I2FMK6_USTH4 (tr|I2FMK6) Methylenetetrahydrofolate reductase OS=Ustilago hordei
(strain Uh4875-4) GN=UHOR_06636 PE=3 SV=1
Length = 649
Score = 361 bits (927), Expect = 3e-97, Method: Compositional matrix adjust.
Identities = 178/393 (45%), Positives = 246/393 (62%), Gaps = 15/393 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R+ +SFE+FPP+T G+ NL++R++RM P F DITW AGG T+D+T + + +
Sbjct: 32 RIWWSFEYFPPRTAQGLTNLYDRIERMADLGPEFVDITWNAGGRTSDLTASLVKTVHTYI 91
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP EKID AL+ K G +N+LALRGDPP GQ ++ GF A++L
Sbjct: 92 GLETCMHLTCTNMPREKIDRALKEAKQFGCRNILALRGDPPAGQSEWEPHAAGFTRAKEL 151
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR +YGDYF I VA +PE HP+A G EL LK K+DAGAD I TQ+
Sbjct: 152 VEYIRQQYGDYFAIAVAAFPEGHPEAFHGPG--------KELERLKEKIDAGADFIFTQM 203
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD DIF K++ + GI CPI+PG+MPI Y GF R T T +P AL+P+KD
Sbjct: 204 FYDFDIFAKWLKEVRAAGINCPIIPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVKD 263
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
+++ V+ G L EMC+KI+ GI LH+YT+N+EK + +L LGL L
Sbjct: 264 DDQKVRDVGTRLVGEMCKKIVGSGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPL 323
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PW R E +RPIFWANR KSY++RT WD++P+GRWGD+ +P+YG + Y ++
Sbjct: 324 PWTPSLTPKRRDEKIRPIFWANRAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VK 382
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
R +++ + W P S+ED V L+ +C
Sbjct: 383 LRYSNQEAKQMWGNPT-SLED---VKALFQNFC 411
>B9DHL6_ARATH (tr|B9DHL6) Methylenetetrahydrofolate reductase (Fragment)
OS=Arabidopsis thaliana GN=AT3G59970 PE=2 SV=1
Length = 402
Score = 360 bits (925), Expect = 4e-97, Method: Compositional matrix adjust.
Identities = 161/204 (78%), Positives = 182/204 (89%)
Query: 193 VTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALE 252
VTQLFYDTDIFLKFVNDC QIGI CPIVPGIMPI+NYKGF+RM GFCKTKIPAE+ AALE
Sbjct: 1 VTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALE 60
Query: 253 PIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISR 312
PIKDN+EAVK YGIH TEMC+KILAHGI +LHLYTLN++KSA+ IL +LGLI+ESKISR
Sbjct: 61 PIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNLGLIDESKISR 120
Query: 313 SLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQF 372
SLPWRRP NVFR +EDVRPIFWANRPKSYISRT GW+ +PHGRWGDS + +Y L+DYQF
Sbjct: 121 SLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSAAYSTLSDYQF 180
Query: 373 MRPRARDKKLTEEWAVPLRSIEDI 396
RP+ RDKKL +EW VPL+SIED+
Sbjct: 181 ARPKGRDKKLQQEWVVPLKSIEDV 204
>M5ED31_MALSM (tr|M5ED31) Genomic scaffold, msy_sf_16 OS=Malassezia sympodialis
ATCC 42132 GN=MSY001_2971 PE=4 SV=1
Length = 591
Score = 360 bits (925), Expect = 5e-97, Method: Compositional matrix adjust.
Identities = 179/394 (45%), Positives = 245/394 (62%), Gaps = 16/394 (4%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R +SFE+FPP+T G+ NL +R++RM P F DITW AGG T+D+T ++ +Q
Sbjct: 21 RTWWSFEYFPPRTPQGMSNLLDRIERMGKLGPEFVDITWNAGGRTSDLTTQLVKTVQAYF 80
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMP KID AL+ K G +N+LALRGDPP ++ GFA +L
Sbjct: 81 GLETCMHLTCTNMPRSKIDVALREAKDFGCRNILALRGDPPACGSEWEPHAAGFAHCHEL 140
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V +IRA YGDYF I VAG+PE HP+A TE + E+ YLK K+D G+D I TQ+
Sbjct: 141 VSYIRANYGDYFTIAVAGFPEGHPEA--------TEGPEKEMEYLKQKIDCGSDFIFTQM 192
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+ +V GIT PIVPG+MPI NY GF R + +P AAL+P+K+
Sbjct: 193 FYDLDTFVDWVRRVRAAGITVPIVPGVMPIQNYGGFSRAVARFRAHVPPHFHAALDPVKE 252
Query: 257 NEEAVKLYGIHLGTEMCRKILAH---GIKTLHLYTLNMEKSALAILTSLGLIEESKISRS 313
++E V+L G L +MCRKIL H I LH+YT+N+E+ + +L L L +
Sbjct: 253 DDEQVRLVGTRLVGDMCRKILEHPDLDIHGLHIYTMNLERGSRMLLEYLQLTPSVQQLNP 312
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
LPW+ R E +RPIFWANR KSY+SRT GWD++P+GRWGD+ +P+YG + Y M
Sbjct: 313 LPWKPSLTPKRRDERIRPIFWANRAKSYVSRTDGWDEFPNGRWGDARSPAYGDVDAYG-M 371
Query: 374 RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
PR + + W P ++ED+ L++++C
Sbjct: 372 HPRLQKDEALALWGAP-ETLEDLQ---RLFVRFC 401
>K1XFY5_MARBU (tr|K1XFY5) Methylenetetrahydrofolate reductase OS=Marssonina
brunnea f. sp. multigermtubi (strain MB_m1) GN=MBM_01665
PE=3 SV=1
Length = 641
Score = 360 bits (923), Expect = 7e-97, Method: Compositional matrix adjust.
Identities = 188/391 (48%), Positives = 251/391 (64%), Gaps = 13/391 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
+ FSFEFFPPKT GV NL++RMDRM PSF DITWGAGG A +T E+ + Q+
Sbjct: 15 QTTFSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAQLTCEMVSVAQSQY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+M E +D AL+ G N+LALRGDPP ++K+V TEGGF A+DL
Sbjct: 75 GLETCMHLTCTDMGQEMVDAALRDAYKAGCTNILALRGDPPREKEKWVATEGGFQYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VKHIR YG++F I VAGYPE G D E L +LK KVDAGA IVTQ+
Sbjct: 135 VKHIRDTYGNHFDIGVAGYPE------GCDDQDDPELL---LEHLKQKVDAGATFIVTQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD + F++++ GIT PIVPGIMPIN Y F+R +IP E AALE +K+
Sbjct: 186 FYDAENFIEWLGKVRAKGITVPIVPGIMPINTYASFLRRCSHMGCRIPPEWSAALEVVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSL 314
++ AV+ G L EMCRK+LA GI LH YT+N+ ++ +L L L E+ +L
Sbjct: 246 DDSAVRNIGTGLVAEMCRKLLAAGIHHLHFYTMNLAQATRMLLDELKLTPSEQRPFKHAL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ ++ R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 306 PWRQSLSLGRRDEDVRPIFWKNRNKSYVTRTQDWDEFPNGRWGDSRSPAFGELDAYG-IG 364
Query: 375 PRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ +++ + W P +SI+DI + + YL+
Sbjct: 365 LKGTNEQNRKLWGEP-KSIKDIADIFVKYLE 394
>J9J1L8_9SPIT (tr|J9J1L8) Methylenetetrahydrofolate reductase OS=Oxytricha
trifallax GN=OXYTRI_12424 PE=3 SV=1
Length = 596
Score = 359 bits (922), Expect = 9e-97, Method: Compositional matrix adjust.
Identities = 176/405 (43%), Positives = 264/405 (65%), Gaps = 21/405 (5%)
Query: 1 MKVIEKVRXXXXXDPD--RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAG 58
MK+I+K+ D + +SFE+FP +TE G++NL +R++RM + NP + D+TW AG
Sbjct: 1 MKIIDKINQVLEEDQSNKKTFYSFEYFPARTEQGIENLLDRIERMGSTNPLWVDVTWNAG 60
Query: 59 GSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
GS++D TLE+ + +QN ++ ++HLTCT M EKI ++L K G++N+LALRGDPP
Sbjct: 61 GSSSDQTLELCSHIQNFSGLDVLMHLTCTFMDREKIVSSLDRAKELGIKNLLALRGDPPR 120
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
G ++ E GF A DLVK IR +YGDYF I VAGYPE H A + ++++
Sbjct: 121 GAKDWIPIENGFNYAVDLVKFIREQYGDYFCIGVAGYPEVHLSAT---------SREDDI 171
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK KVDAGAD I+TQLFYD ++F+++V DC + GI C I+PGI+PI Y+ F + F
Sbjct: 172 RYLKEKVDAGADFIITQLFYDNNLFVEWVADCRRAGIECQIIPGILPILGYERFNKTIQF 231
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAI 298
CKT +P +I+ LEPIK+++E V+ YG+ G E CR+++ G + LH YT+N+E + + I
Sbjct: 232 CKTIVPQKILDDLEPIKNDDEEVRKYGVKFGIEQCRELIDQGTRFLHFYTMNLETAVVNI 291
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
+ LG+++ K LP+++ + R E+VRPIFWA +PKSYISRT WD++P+GRWG
Sbjct: 292 IKGLGILDRQK---DLPFKKLS--CRRTEEVRPIFWAIKPKSYISRTQEWDEFPNGRWGV 346
Query: 359 SGNPSYGALTDYQFMRPRA-----RDKKLTEEWAVPLRSIEDIYV 398
S +P++G Y + + +K+ E L+ I +I++
Sbjct: 347 SRSPAFGEPEMYGSIAKKISFNFDEQRKIYGENVNSLQDISEIFI 391
>I1CMT8_RHIO9 (tr|I1CMT8) Methylenetetrahydrofolate reductase OS=Rhizopus delemar
(strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
43880) GN=RO3G_14479 PE=3 SV=1
Length = 562
Score = 359 bits (922), Expect = 1e-96, Method: Compositional matrix adjust.
Identities = 180/374 (48%), Positives = 240/374 (64%), Gaps = 15/374 (4%)
Query: 40 MDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQ 99
M+RM + P F DITWGAGGS+A++T EI Q++ +ETM+HLTCTNMPVEKID AL+
Sbjct: 1 MERMQRYGPEFIDITWGAGGSSAELTTEIVATSQSVYGLETMMHLTCTNMPVEKIDKALE 60
Query: 100 TIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAH 159
K G QN+LALRGDPP GQ + E GF A DLV++IR KYGDYF I VAG+PE H
Sbjct: 61 AAKKCGCQNILALRGDPPKGQLNWESCENGFQYAIDLVRYIRQKYGDYFCIAVAGHPEGH 120
Query: 160 PDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPI 219
D Q++L LK KVDAGADLI+TQLF+D D+F++FV C +IGI CPI
Sbjct: 121 ID---------NPDKQDDLQRLKEKVDAGADLIITQLFFDVDVFVQFVRKCREIGIQCPI 171
Query: 220 VPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH 279
+PG+ PI +Y G R+ F +P +I LE IK++++AVK YGIHL + ++I
Sbjct: 172 LPGLFPIQSYSGLSRVISFNNNHVPQKIWDDLETIKEDDQAVKDYGIHLAIQFVKQIKKE 231
Query: 280 -GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRP 338
GI H+YT N+E+S+ IL LGL+ + + + LPW R +E VRPIFW NR
Sbjct: 232 TGISGFHIYTFNLERSSRLILERLGLVPQLEYVKPLPWNPSLGPKRTKETVRPIFWKNRT 291
Query: 339 KSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYV 398
SYI RT WD++P+GRWGD+ +P++G + DK+L W P +S++DI
Sbjct: 292 HSYIQRTESWDEFPNGRWGDARSPAFGEFDRWGVSIKYPVDKQLA-MWGTP-QSVDDI-- 347
Query: 399 VGLLYLQYCYSFLD 412
LL+ +YC L+
Sbjct: 348 -ALLFARYCKGRLE 360
>G2WQ21_VERDV (tr|G2WQ21) Methylenetetrahydrofolate reductase OS=Verticillium
dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
GN=VDAG_00463 PE=3 SV=1
Length = 609
Score = 358 bits (919), Expect = 2e-96, Method: Compositional matrix adjust.
Identities = 179/388 (46%), Positives = 249/388 (64%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q++ +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNFGPKFIDITWGAGGRIAELTCEMVTQAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M ++K+++AL+ G N+LALRGDPP ++K+V +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNDALRKAYKAGCTNILALRGDPPREKEKWVAADGGFEYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA Y D+F I VAGYPE G + ++ L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPE---------GCDDNKDEESLLDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PIVPGIMPI Y F+R +P E M ALEP+K+++
Sbjct: 189 ADNFVRWVGKVRERGITIPIVPGIMPIATYASFMRRAKHMNCSVPQEFMDALEPVKNDDN 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L MCRKILA GI LH YT+N+ ++ +L L + E + ++LPW+
Sbjct: 249 AVREVGKVLVAGMCRKILAAGIHHLHFYTMNLAQATRMVLEELNWMPTSERPLKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW R KSYI RT WD++P+GRWGDS +P++G L Y
Sbjct: 309 QSLGLGRREEDVRPIFWKGRNKSYILRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGT 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ + ++W P ++++DI + + YL+
Sbjct: 369 NEQNI-KKWGEP-QTVQDIATLFVRYLR 394
>L8X3I0_9HOMO (tr|L8X3I0) Methylenetetrahydrofolate reductase OS=Rhizoctonia
solani AG-1 IA GN=AG1IA_02305 PE=3 SV=1
Length = 645
Score = 358 bits (919), Expect = 2e-96, Method: Compositional matrix adjust.
Identities = 177/364 (48%), Positives = 239/364 (65%), Gaps = 12/364 (3%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MKV EK++ R+ +SFE+FPP+T G+ NL +R++RM P F DITW AGG
Sbjct: 1 MKVTEKIQQAEKDG--RIWWSFEYFPPRTAQGLQNLLDRIERMRGLGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+D+T E+ Q ++ +ET +HLTCTNMP EK+D AL+ K+NG +N+LALRGDPP GQ
Sbjct: 59 TSDLTSELVKTCQGVIGIETCMHLTCTNMPQEKVDVALREAKANGCRNILALRGDPPSGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+++ EGGF DLVKHIR ++ DYF I VAG+P+ + + EA Q E+ +
Sbjct: 119 EEWTTVEGGFQHGIDLVKHIRREHDDYFDIAVAGFPQ-------TIQLPEAEAKQ-EMQW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K DAGA+ I TQ+FYD D+F+++V GIT PIVPGI PI + GFIR T
Sbjct: 171 LKEKCDAGANFIFTQMFYDADMFIRWVKAARDAGITVPIVPGINPIQTWNGFIRATTLSG 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKIL--AHGIKTLHLYTLNMEKSALAI 298
T IP ++M LEP K+N+E V+ G + +++CRKIL GIK LH YT+N+EK +
Sbjct: 231 TDIPQDLMDILEPHKNNDEKVRELGTKIVSDLCRKILDAGIGIKGLHFYTMNLEKGTKML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R E +RPIFWANR KSY+SRT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRVETIKPLPWRQSLTPTRRTETIRPIFWANRTKSYLSRTENWDEYPNGRFGD 350
Query: 359 SGNP 362
S +P
Sbjct: 351 SRSP 354
>N4VAU1_COLOR (tr|N4VAU1) Methylenetetrahydrofolate reductase 1 OS=Colletotrichum
orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 /
LARS 414 / MAFF 240422) GN=Cob_10442 PE=4 SV=1
Length = 625
Score = 358 bits (919), Expect = 2e-96, Method: Compositional matrix adjust.
Identities = 183/388 (47%), Positives = 249/388 (64%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q+I +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVLQAQSIYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M +EK+++AL+ G N+LALRGDPP +K+ T+ GF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALRKAYKAGCTNILALRGDPPREHEKWEATDDGFQYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA Y D+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPEGCDDNKDEDQL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R K+P E MAALEP+K+++
Sbjct: 189 GDNFVRWVGKVRERGITVPIIPGIMPIATYASFLRRAKHMNCKVPDEWMAALEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L +MCRKILA GI LH YT+N+ ++ +L L + E + +LPW+
Sbjct: 249 AVREIGKGLVADMCRKILAAGIHHLHFYTMNLAQATRMVLEELNWMPSNERPLKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW R KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWKGRNKSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ ++W P RSI+DI + + YL+
Sbjct: 368 TNEQNRKKWGEP-RSIKDIANIFVRYLE 394
>C7Z4M2_NECH7 (tr|C7Z4M2) Methylenetetrahydrofolate reductase OS=Nectria
haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596
/ MPVI) GN=NECHADRAFT_32750 PE=3 SV=1
Length = 618
Score = 358 bits (919), Expect = 2e-96, Method: Compositional matrix adjust.
Identities = 180/388 (46%), Positives = 244/388 (62%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRDQDKWTAADGGFQYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR+ YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRSTYGNHFDIGVAGYPEGCDDNKNEDEL---------LDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V G+ PI+PGIMPI Y F+R K KIP + ALEP+K+++
Sbjct: 189 ADNFIRWVKKVRDRGVNVPILPGIMPIATYASFLRRANHMKAKIPQAWLDALEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L EMCRK+LA+GI LH YT+N+ ++ +L L E + +LPW+
Sbjct: 249 AVRDIGKSLVAEMCRKLLANGIHHLHFYTMNLAQATRMVLEELNWAPSAERPLQHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y
Sbjct: 309 QSKGLGRREEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGT 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ ++W P ++++DI + + YL+
Sbjct: 369 NEAN-RKKWGEP-KTVQDIAQLFVRYLR 394
>K3VHJ6_FUSPC (tr|K3VHJ6) Methylenetetrahydrofolate reductase OS=Fusarium
pseudograminearum (strain CS3096) GN=FPSE_05848 PE=3
SV=1
Length = 621
Score = 358 bits (919), Expect = 2e-96, Method: Compositional matrix adjust.
Identities = 181/388 (46%), Positives = 245/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWEAADGGFQYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRNTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 189 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L MCRK+LA+GI LH YT+N+ ++ +L L + + +LPW+
Sbjct: 249 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEELQWAPSADRPLQHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSKGLGRREEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGS 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ ++W P ++I+DI + + YL
Sbjct: 369 NEAN-RKKWGEP-KAIQDIAQLFVSYLN 394
>I1RYW1_GIBZE (tr|I1RYW1) Methylenetetrahydrofolate reductase OS=Gibberella zeae
(strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
GN=FG09572.1 PE=3 SV=1
Length = 616
Score = 358 bits (918), Expect = 3e-96, Method: Compositional matrix adjust.
Identities = 181/388 (46%), Positives = 245/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 13 FSFEYFPPKTAQGVQNLYDRMDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQAVYGLE 72
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP QDK+ +GGF ARDLVKH
Sbjct: 73 TCMHLTCTDMGVEKVNDALLKAYKAGCTNILALRGDPPRAQDKWEAADGGFQYARDLVKH 132
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 133 IRNTYGNHFDIGVAGYPEGSDDNKNEDEL---------LDHLKEKVDMGATFIVTQMFYD 183
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + KIP E + ALEP+K+++
Sbjct: 184 ADNFIRWVKRVRERGITIPILPGIMPIATYASFLRRANHMQAKIPQEWLDALEPVKNDDV 243
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L MCRK+LA+GI LH YT+N+ ++ +L L + + +LPW+
Sbjct: 244 AVRNIGKTLVANMCRKLLANGIHHLHFYTMNLAQATRMLLEELQWAPSADRPLQHALPWK 303
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 304 QSKGLGRREEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGS 363
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ ++W P ++I+DI + + YL
Sbjct: 364 NEAN-RKKWGEP-KAIQDIAELFVSYLN 389
>E9ED23_METAQ (tr|E9ED23) Methylenetetrahydrofolate reductase OS=Metarhizium
acridum (strain CQMa 102) GN=MAC_07771 PE=3 SV=1
Length = 624
Score = 357 bits (917), Expect = 3e-96, Method: Compositional matrix adjust.
Identities = 179/388 (46%), Positives = 249/388 (64%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++R+DRM P F DITWGAGG A++T E+ + Q++ +E
Sbjct: 47 FSFEYFPPKTAQGVQNLYDRIDRMYNFGPKFIDITWGAGGRIAELTCEMVLQAQSVYGLE 106
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M +EK+++AL+ G N+LALRGDPP Q+K+ TEGGF ARDLVKH
Sbjct: 107 TCMHLTCTDMGLEKVNDALKKAYKAGCTNILALRGDPPRAQEKWTATEGGFHYARDLVKH 166
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA YGD+F I VAGYPE G + + L +LK KVD GA IVTQ+FYD
Sbjct: 167 IRATYGDHFDIGVAGYPE---------GCDDNKDEEQLLDHLKEKVDMGASFIVTQMFYD 217
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GI PI+PGIMPI Y F+R + K+P M ALEP+K+++
Sbjct: 218 ADNFVRWVGKVRERGINIPILPGIMPIATYASFLRRAKHMQCKVPDHWMTALEPVKNDDV 277
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSL--GLIEESKISRSLPWR 317
AV+ G L +MCRK+LA+GI LH YT+N+ ++ +L L E + ++LPW+
Sbjct: 278 AVREIGKTLVADMCRKLLANGIYHLHFYTMNLAQATRMVLEELTWAPCAERPLQQALPWK 337
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 338 QSKALGRRDEDVRPIFWRNRNKSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 396
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ ++W P +++DI + + YL
Sbjct: 397 TNEANRKKWGEPT-TVQDIASIFVKYLN 423
>E1Z340_CHLVA (tr|E1Z340) Methylenetetrahydrofolate reductase OS=Chlorella
variabilis GN=CHLNCDRAFT_33591 PE=3 SV=1
Length = 328
Score = 357 bits (916), Expect = 5e-96, Method: Compositional matrix adjust.
Identities = 174/306 (56%), Positives = 213/306 (69%), Gaps = 17/306 (5%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
+ FSFE+FPPKT++GV NL ER RM A P FCDITWGAGGSTA+VTL++A MQ V
Sbjct: 16 KSFFSFEYFPPKTDEGVHNLKERQMRMAALGPCFCDITWGAGGSTAEVTLDVARSMQQEV 75
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
VETM+HLTCTNMPVEK+ AL K G+ N+LALRGDPP GQD F EGGF+CA DL
Sbjct: 76 GVETMMHLTCTNMPVEKLKEALTKAKEYGITNILALRGDPPKGQDHFEVVEGGFSCALDL 135
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IRA++GD+FGI V+GYPEAHPD I D + Y ++ YLK K++AGAD +VTQL
Sbjct: 136 VKYIRAEHGDFFGIGVSGYPEAHPDVIVEDERQMRKNYWADIEYLKQKMEAGADFVVTQL 195
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D +L+FV DC +GIT PI+PG+MPI Y GF RMT FCKT +P I LE IK
Sbjct: 196 FYDCDRYLQFVKDCRSVGITAPILPGVMPIMTYGGFKRMTSFCKTAVPQHIADTLETIKG 255
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPW 316
++EA YGI LGT MC+++LA G +H+YTLN+E+SA +L W
Sbjct: 256 SDEAA--YGISLGTMMCQRLLASGAPGVHMYTLNLERSA---------------GEALGW 298
Query: 317 RRPTNV 322
RR V
Sbjct: 299 RRAAPV 304
>Q75EA7_ASHGO (tr|Q75EA7) Methylenetetrahydrofolate reductase OS=Ashbya gossypii
(strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
Y-1056) GN=AGOS_AAR170W PE=3 SV=2
Length = 603
Score = 357 bits (916), Expect = 5e-96, Method: Compositional matrix adjust.
Identities = 181/400 (45%), Positives = 251/400 (62%), Gaps = 23/400 (5%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
+ FSFEFF PKT GV NL++RMDRM P F DITW AGG + T E+ Q ++
Sbjct: 20 KASFSFEFFVPKTLQGVQNLYDRMDRMYQTQPEFIDITWNAGGRLSQRTSELVATSQGVL 79
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNM +D AL+ G +N+LALRGDPP Q + GGF A+DL
Sbjct: 80 GLETCMHLTCTNMSTALVDEALERAYEAGCENILALRGDPPL-QGTWEPCAGGFRYAKDL 138
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V HIRA+YGD+F + VAGYPE H +A G++ + YLK KVDAGAD I+TQ+
Sbjct: 139 VAHIRARYGDHFDVGVAGYPEGHEEASGAELIG----------YLKEKVDAGADFIITQM 188
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D+FLK+ + GI+ PI+PGIMPI +Y +R +C+ ++P E + LEP+KD
Sbjct: 189 FYDADLFLKWCDAVRAAGISVPIIPGIMPITSYAALLRRAKWCQVRLPPEFLERLEPVKD 248
Query: 257 NEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIE--------E 307
+++AV+ G L +MCRKILA G + LHLYT+N+E+++L IL L LI+
Sbjct: 249 DDQAVREIGTVLVADMCRKILASGHVTHLHLYTMNLERASLMILERLQLIDTGGAGVRRR 308
Query: 308 SKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQYPHGRWGDSGNPSYG 365
+ +LPWR+ N R +E VRPIFW RP SY++RT W D++P+GR+GDS +P+YG
Sbjct: 309 PSTNETLPWRKSLNPTRRKEGVRPIFWQRRPYSYVARTSQWSADEFPNGRFGDSSSPAYG 368
Query: 366 ALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
L R ++ E W+ P R++ D+ + + YL+
Sbjct: 369 DLDLCGHTVLRQTYQRSLELWSTP-RTLLDLAALVISYLK 407
>M9MW94_ASHGS (tr|M9MW94) FAAR170Wp OS=Ashbya gossypii FDAG1 GN=FAGOS_FAAR170W
PE=4 SV=1
Length = 603
Score = 357 bits (916), Expect = 5e-96, Method: Compositional matrix adjust.
Identities = 183/419 (43%), Positives = 259/419 (61%), Gaps = 26/419 (6%)
Query: 1 MKVIEKVRX---XXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGA 57
M++ +K++ + + FSFEFF PKT GV NL++RMDRM P F DITW A
Sbjct: 1 MRISQKLKQRAGAAAEEQPKASFSFEFFVPKTLQGVQNLYDRMDRMYQTQPEFIDITWNA 60
Query: 58 GGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPP 117
GG + T E+ Q ++ +ET +HLTCTNM +D AL+ G +N+LALRGDPP
Sbjct: 61 GGRLSQRTSELVATSQGVLGLETCMHLTCTNMSTALVDEALERAYEAGCENILALRGDPP 120
Query: 118 HGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNE 177
Q + GGF A+DLV HIRA+YGD+F + VAGYPE H +A G++ +
Sbjct: 121 L-QGTWEPCAGGFRYAKDLVAHIRARYGDHFDVGVAGYPEGHEEASGAELIG-------- 171
Query: 178 LTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTG 237
YLK KVDAGAD I+TQ+FYD D+FLK+ + GI+ PI+PGIMPI +Y +R
Sbjct: 172 --YLKEKVDAGADFIITQMFYDADLFLKWCDAVRAAGISVPIIPGIMPITSYAALLRRAK 229
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSAL 296
+C+ ++P E + LEP+KD+++AV+ G L +MCRKILA G + LHLYT+N+E+++L
Sbjct: 230 WCQVRLPPEFLERLEPVKDDDQAVREIGTVLVADMCRKILASGHVTHLHLYTMNLERASL 289
Query: 297 AILTSLGLIE--------ESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW 348
IL L LI+ + +LPWR+ N R +E VRPIFW RP SY++RT W
Sbjct: 290 MILERLQLIDTGGAGVRRRPSTNETLPWRKSLNPTRRKEGVRPIFWQRRPYSYVARTSQW 349
Query: 349 --DQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
D++P+GR+GDS +P+YG L R ++ E W+ P R++ D+ + + YL+
Sbjct: 350 SADEFPNGRFGDSSSPAYGDLDLCGHTVLRQTYQRSLELWSTP-RTLLDLAALVISYLK 407
>M1WGQ3_CLAPU (tr|M1WGQ3) Methylenetetrahydrofolate reductase OS=Claviceps
purpurea 20.1 GN=CPUR_05837 PE=3 SV=1
Length = 595
Score = 356 bits (914), Expect = 8e-96, Method: Compositional matrix adjust.
Identities = 178/383 (46%), Positives = 245/383 (63%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL+ER+DRM P F DITWGAGG A++T E+ + Q++ +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYERIDRMYNLGPKFIDITWGAGGRIAELTCEMVLQAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M ++K+++ALQ G N+LALRGDPP Q+++ TE GF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNDALQRAYKAGCTNILALRGDPPRAQEQWTATEDGFQYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA YG +F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRATYGAHFDIGVAGYPEGCDDNKDEDQL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F++++ + GIT P++PGIMPI Y F+R + K+P MAALEP+K+++
Sbjct: 189 ADNFIRWLRKVRERGITIPVLPGIMPIATYASFLRRAKHMQCKVPEAWMAALEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L EMCRK+LA+GI LH YT+N+ ++ +L L E + +LPW+
Sbjct: 249 AVREIGTTLVAEMCRKLLANGIYHLHFYTMNLAQATRMVLDELNWAPCAERPLKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR +SY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSKALGRRDEDVRPIFWRNRNRSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
++ +W P ++ I DI+V
Sbjct: 368 TNEANRNKWGEPTTVQEIADIFV 390
>E9END5_METAR (tr|E9END5) Methylenetetrahydrofolate reductase OS=Metarhizium
anisopliae (strain ARSEF 23 / ATCC MYA-3075)
GN=MAA_01221 PE=3 SV=1
Length = 595
Score = 356 bits (914), Expect = 8e-96, Method: Compositional matrix adjust.
Identities = 179/387 (46%), Positives = 247/387 (63%), Gaps = 13/387 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++R+DRM P F DITWGAGG A++T E+ + Q++ +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRIDRMYNFGPKFIDITWGAGGRIAELTCEMVLQAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M ++K++ ALQ G N+LALRGDPP Q+K+ EGGF ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNAALQKAYKAGCTNILALRGDPPRAQEKWTAAEGGFHYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA YGD+F I VAGYPE G + + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRATYGDHFDIGVAGYPE---------GCDDNKDEEQLLDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GI PI+PGIMPI Y F+R + K+P M ALEP+K+++
Sbjct: 189 ADNFVRWVGKVRERGINIPILPGIMPIATYASFLRRAKHMQCKVPDHWMTALEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L EMCRK+LA+GI LH YT+N+ ++ +L L E + ++LPW+
Sbjct: 249 AVREIGKTLVAEMCRKLLANGIYHLHFYTMNLAQATRMLLEELTWAPCAERPLQQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSKALGRRDEDVRPIFWRNRNKSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++W P +++DI + + YL
Sbjct: 368 TNEANRKKWGEPT-TVQDIASIFVKYL 393
>H6C648_EXODN (tr|H6C648) Methylenetetrahydrofolate reductase OS=Exophiala
dermatitidis (strain ATCC 34100 / CBS 525.76 /
NIH/UT8656) GN=HMPREF1120_07191 PE=3 SV=1
Length = 648
Score = 355 bits (912), Expect = 2e-95, Method: Compositional matrix adjust.
Identities = 179/390 (45%), Positives = 244/390 (62%), Gaps = 14/390 (3%)
Query: 19 VFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCV 78
FSFEFFPPKT GV NL++RMDRM P+F DITWGAGG + +T E+ N Q+ +
Sbjct: 17 TFSFEFFPPKTAQGVQNLYDRMDRMHDLGPAFIDITWGAGGRHSQLTCEMVNAAQSHYGL 76
Query: 79 ETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVK 138
ET +HLTCT+M ++D AL+ G N+LALRGDPP Q+K+ + GF A+DLV+
Sbjct: 77 ETCMHLTCTDMERTQVDEALRLAYKAGCTNILALRGDPPRDQEKWEAKDAGFRYAKDLVR 136
Query: 139 HIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFY 198
+IRA+YGD+F I VAGYPE D D + + +LK KVDAGA +VTQ+FY
Sbjct: 137 YIRARYGDHFDIGVAGYPEGCDDHRDVDLL---------IEHLKEKVDAGATFVVTQMFY 187
Query: 199 DTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNE 258
D DIFL +V C GI PI+PGIMPI+ Y FIR + K +P E ALEP+K+++
Sbjct: 188 DVDIFLNWVQKCRNRGINVPILPGIMPISTYAAFIRRANWTKCHVPPEWYEALEPVKNDD 247
Query: 259 EAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEES---KISRSLP 315
AV+ G L +MCR+IL GI LH YT+N+ ++ IL L L E ++ + LP
Sbjct: 248 AAVRDIGKDLVAQMCRRILDAGIHHLHFYTMNLAQATRMILEELALTPEKSGRRLEKPLP 307
Query: 316 WRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRP 375
WR+ R E VRPIFW NR SY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 308 WRQSLGFNRRDETVRPIFWRNRNTSYVARTADWDEFPNGRWGDSRSPAFGELDAYG-VGL 366
Query: 376 RARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+ ++ + W P +S+ D+ + + YLQ
Sbjct: 367 KGTNEANMKLWGRP-KSLRDVTALFVRYLQ 395
>B3S098_TRIAD (tr|B3S098) Methylenetetrahydrofolate reductase OS=Trichoplax
adhaerens GN=TRIADDRAFT_26971 PE=3 SV=1
Length = 633
Score = 355 bits (911), Expect = 2e-95, Method: Compositional matrix adjust.
Identities = 169/404 (41%), Positives = 248/404 (61%), Gaps = 18/404 (4%)
Query: 3 VIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW----GAG 58
+I+K+R + +S EFFPP+T+ G NL R DR+ NP F D+TW +G
Sbjct: 26 IIQKIRKRI--NSGDKFYSLEFFPPRTDSGGVNLIARFDRLAIGNPLFIDVTWHPKGNSG 83
Query: 59 GSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
G +L IA+ N +++M+H+TC N E ID L+ K GL+N+LALRGD
Sbjct: 84 GDEVTASLTIASAALNFCGLDSMLHMTCINSTTEDIDKYLRKAKKQGLRNILALRGDVSD 143
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
D+ V+ A DLVKHIR ++G+YFGI VAGYP+ HP+ +Y++++
Sbjct: 144 SIDESVRHTKELKYASDLVKHIRKEFGNYFGIAVAGYPDGHPEC---------SSYEDDI 194
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
LK K+D G D +VTQLF+D + + KF+ DC GIT PI+PGI+PI Y +
Sbjct: 195 RRLKEKLDNGGDFVVTQLFFDAETYFKFLRDCRNAGITAPIIPGILPIQGYNSLRHLVQL 254
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
K +P I+ +E IKDN+EA++ +GI T +C+K+LA + +H+YTLN E++ +
Sbjct: 255 SKLPVPQRILDTIESIKDNDEAIRKFGIVEATNLCKKLLASDDVPGIHVYTLNREEAVVK 314
Query: 298 ILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWG 357
+L +GL E I +SLPWR N R+ EDVRPIFWA+RPKSY+ RT+ WD+YP+GRWG
Sbjct: 315 LLKRVGLWHEESIYKSLPWRPSANGKRISEDVRPIFWASRPKSYVHRTMMWDEYPNGRWG 374
Query: 358 DSGNPSYGALTDYQ--FMRPRARDKKLTEEWAVPLRSIEDIYVV 399
S +P++G L DY +++ ++ +L + W L S+ED+Y +
Sbjct: 375 SSASPAFGELKDYHIFYLKNTSKKDELLKMWGEKLESVEDVYEI 418
>R9AFX7_WALIC (tr|R9AFX7) Methylenetetrahydrofolate reductase 2 OS=Wallemia
ichthyophaga EXF-994 GN=J056_004424 PE=4 SV=1
Length = 600
Score = 355 bits (910), Expect = 2e-95, Method: Compositional matrix adjust.
Identities = 176/372 (47%), Positives = 238/372 (63%), Gaps = 10/372 (2%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K+ D R+ +SFEFFPP+T G+ NL +R++RM P F DITW +GG
Sbjct: 1 MKITDKLLAAERED--RLWWSFEFFPPRTAQGMTNLVDRIERMRRLGPEFIDITWHSGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
TA++T E+ Q + VET +HLTCT MP EK+ NAL+ K NG NVLALRGDPP GQ
Sbjct: 59 TAELTTELVKTCQASIGVETCMHLTCTGMPREKVINALEEAKKNGCTNVLALRGDPPRGQ 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
++ GF A DLVKHI++ YGDYF + VAG+PE + S A E+ Y
Sbjct: 119 TEWYPHPNGFTYAVDLVKHIKSVYGDYFEVAVAGFPEGNLQYKHSSDKAL------EMQY 172
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KV+AGADLI+TQ+FYD D F+ + + GIT PIVPGIMPI + GF + +
Sbjct: 173 LKEKVEAGADLIMTQMFYDVDNFIDWCKQVRKAGITVPIVPGIMPIQTWNGFQKAVQMAQ 232
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
+P M LE +K+++ +V+ G L ++MC++IL GI+ LHLYT+N+E+ I
Sbjct: 233 ANVPESWMQQLEAVKEDDASVRKVGTKLVSQMCKQILDANIGIRGLHLYTMNLERGPKMI 292
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L LI +++I LPWR R E++RPIFWANR KSY+SRT WD++P+GRWGD
Sbjct: 293 LQELNLIPQTQILNPLPWRPSLTPMRRTENIRPIFWANRQKSYLSRTEMWDEFPNGRWGD 352
Query: 359 SGNPSYGALTDY 370
S +P+YG L +
Sbjct: 353 SRSPAYGELDGW 364
>H2ANE8_KAZAF (tr|H2ANE8) Methylenetetrahydrofolate reductase OS=Kazachstania
africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 /
CECT 1963 / NBRC 1671 / NRRL Y-8276) GN=KAFR0A04630 PE=3
SV=1
Length = 598
Score = 354 bits (909), Expect = 3e-95, Method: Compositional matrix adjust.
Identities = 188/414 (45%), Positives = 259/414 (62%), Gaps = 21/414 (5%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHN-PSFCDITWGAGG 59
MK+ EK++ + +SFE+F PKT GV NL++RMD+M + P F DITW AGG
Sbjct: 1 MKITEKLQQHQEV-CSKPTYSFEYFVPKTTQGVQNLYDRMDKMYQSSLPLFIDITWNAGG 59
Query: 60 ST-ADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
T + ++ E+ + Q+++ +ET +HLTCTNM + ID+AL++ ++G QN+LALRGDPP
Sbjct: 60 GTLSKLSTELVSTSQSVLGLETCMHLTCTNMEISMIDDALESAYNSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+ TEGGFA A+DL+ +IR KYGDYF I VAGYPE HP+ L
Sbjct: 120 DAVNWQPTEGGFAYAKDLISYIRCKYGDYFDIGVAGYPEGHPEEPNK---------LKNL 170
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK KVDAGA+ IVTQ+FYD D F+++ + + GI PI+PGIMPI Y F+R +
Sbjct: 171 KYLKEKVDAGANFIVTQMFYDVDNFIQWCKEVREFGIDVPIIPGIMPITGYAAFLRRASW 230
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP A L+PIKDN+E V+ G L EMCRK+L+ G I LH+YT+N+EK++L
Sbjct: 231 GQINIPKYFFALLDPIKDNDELVREIGTKLVVEMCRKLLSSGYINHLHIYTMNLEKASLM 290
Query: 298 ILTSLGLI--EESKISRS---LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L L+ E ++ LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 291 ILEQLDLLPTENEYLTEPISMLPWRKSLNPKRKFEEVRPIFWQRRPYSYVARTSNWAVDE 350
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R KK E W+ P SI D+ + + YL
Sbjct: 351 FPNGRFGDSSSPAFGELDLCGGTLLRQSSKKCLELWSTP-ESINDLAQLVISYL 403
>G0S5U9_CHATD (tr|G0S5U9) Methylenetetrahydrofolate reductase OS=Chaetomium
thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
GN=CTHT_0033700 PE=3 SV=1
Length = 614
Score = 354 bits (909), Expect = 3e-95, Method: Compositional matrix adjust.
Identities = 181/394 (45%), Positives = 248/394 (62%), Gaps = 13/394 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM + P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYNYGPKFIDITWGAGGRVAELTCEMVVQAQAYLGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VE+I++AL+ G N+LALRGDPP ++K+ + GF A+DLV H
Sbjct: 78 TCMHLTCTDMGVERINDALRKAYKAGCTNILALRGDPPRDKEKWEAAKDGFRYAKDLVAH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR +YGD+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKEYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL++V + GI+ PIVPGIMPI Y F+R K KIP E MA LEP+K+++
Sbjct: 189 VDNFLRWVKKVRERGISVPIVPGIMPIATYASFLRRANHMKCKIPEEWMAKLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L +MCRKIL GI+ LH YT+N+ ++ +L L + + + +LPW+
Sbjct: 249 AVREIGKTLVADMCRKILDAGIRHLHFYTMNLAQATRMVLEELNWLPSPDRPLKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGFGRRGEDVRPIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGVGLTGS 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
++ E W P + I DI + + YL+ +L
Sbjct: 369 NEQN-RERWGEP-KCIRDIANLFIRYLRKEIDYL 400
>K0KJW6_WICCF (tr|K0KJW6) Methylenetetrahydrofolate reductase OS=Wickerhamomyces
ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM
3599 / NBRC 0793 / NRRL Y-1031) GN=BN7_949 PE=3 SV=1
Length = 603
Score = 354 bits (908), Expect = 4e-95, Method: Compositional matrix adjust.
Identities = 175/395 (44%), Positives = 248/395 (62%), Gaps = 15/395 (3%)
Query: 16 DRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNI 75
D FSFEFF PKT GV NL++RMDRM NP F D+TW AGG +++T +I Q++
Sbjct: 15 DIPTFSFEFFVPKTSQGVQNLYDRMDRMYNVNPQFIDVTWNAGGRLSNLTTDIVQTAQSV 74
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ +ET +HLTCTNMPV+ ID AL+ +G QN+LALRGDPP ++ EGGF A+D
Sbjct: 75 LGLETCMHLTCTNMPVDLIDKALKEAYDSGCQNILALRGDPPVEGGEWTAVEGGFQHAKD 134
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVK+IR KYG++F I VA YPE HP+ D + + +LK K+DAGAD I+TQ
Sbjct: 135 LVKYIRNKYGNHFDIGVAAYPEGHPEETDIDLL---------IGFLKEKIDAGADFIITQ 185
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
+FYD + F+++ I PI+PGIMPI+ Y F R + +C+ K+P E L K
Sbjct: 186 MFYDAENFIEWCQKLRDQDINVPIIPGIMPISTYASFKRRSTWCEIKVPEEFENKLLANK 245
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISR-- 312
D+++ V+ G L EMC K++ G +K LH YT+N+EKS++ +L LGLI ++ ++
Sbjct: 246 DDDQLVRKIGTELVAEMCSKLINSGFVKHLHFYTMNLEKSSIMVLEKLGLINSNEQTQNN 305
Query: 313 --SLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY 370
+LPWR+ N R E VRPIFW NR SYI+RT WD++P+GRWGD + ++G + +
Sbjct: 306 TEALPWRKSLNPNRNSETVRPIFWKNRKYSYITRTQDWDEFPNGRWGDPNSAAFGDVELF 365
Query: 371 QFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
R K+ E W P ++ +D+ + + YLQ
Sbjct: 366 TSGLLRQSSKRCIELWGEP-KNFKDVSQLVVKYLQ 399
>H2YN67_CIOSA (tr|H2YN67) Methylenetetrahydrofolate reductase (Fragment) OS=Ciona
savignyi GN=Csa.2215 PE=3 SV=1
Length = 609
Score = 354 bits (908), Expect = 4e-95, Method: Compositional matrix adjust.
Identities = 181/406 (44%), Positives = 248/406 (61%), Gaps = 27/406 (6%)
Query: 2 KVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW----GA 57
K++ +V+ DP FS EFFPP+TE G NL R DRM P F DITW
Sbjct: 8 KILSRVKSK---DP---FFSLEFFPPRTEQGAANLIGRFDRMRQGGPLFVDITWHPAGDP 61
Query: 58 GGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPP 117
GG + +IA + N ++TM+H+TC E I L+ K+ G++N+LALRGD
Sbjct: 62 GGDKITSSTKIAGTVLNYCSLDTMLHMTCVKQTEETIKKNLEKTKNLGIRNILALRGD-- 119
Query: 118 HGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNE 177
+ + TEGGF DLV+ I+ +YGDYF I VAGYP HPD+ +YQ +
Sbjct: 120 -ADENWGITEGGFNYGVDLVRFIKKEYGDYFSICVAGYPNGHPDST---------SYQED 169
Query: 178 LTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTG 237
L +LK K+DAG + ++TQLF+ D FL FV DC +IGITCPI+PGI PI + +++T
Sbjct: 170 LLHLKEKIDAGGEFVITQLFFTADEFLTFVKDCREIGITCPIIPGIFPIQTNRSLVQLTK 229
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSAL 296
K IP EI +EPIKDN+ A++ YGI L T+MCR +L G + LH+YTLN+E + +
Sbjct: 230 LSKLTIPEEIQKVIEPIKDNDAAIRKYGIDLATDMCRSLLNSGEVHGLHMYTLNLEAATI 289
Query: 297 AILTSLGLIEESKISRSLPWRRPTN-VFRVREDVRPIFWANRPKSYISRTIGWDQYPHGR 355
IL +LGL + ++++LPW+ N R E VRPIFW +RPKSYI RT WD++P+GR
Sbjct: 290 QILKNLGLWCQD-VAKTLPWKTSGNPERRENETVRPIFWTDRPKSYIHRTQKWDEFPNGR 348
Query: 356 WGDSGNPSYGALTDYQ--FMRPRARDKKLTEEWAVPLRSIEDIYVV 399
WGDS +P++G L DY F+R R +L +W L S D++ V
Sbjct: 349 WGDSASPAFGELRDYHLFFLRCRTSKDRLRAQWGKELTSETDVWKV 394
>H2YN66_CIOSA (tr|H2YN66) Methylenetetrahydrofolate reductase OS=Ciona savignyi
GN=Csa.2215 PE=3 SV=1
Length = 558
Score = 354 bits (908), Expect = 4e-95, Method: Compositional matrix adjust.
Identities = 181/406 (44%), Positives = 248/406 (61%), Gaps = 27/406 (6%)
Query: 2 KVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW----GA 57
K++ +V+ DP FS EFFPP+TE G NL R DRM P F DITW
Sbjct: 20 KILSRVKSK---DP---FFSLEFFPPRTEQGAANLIGRFDRMRQGGPLFVDITWHPAGDP 73
Query: 58 GGSTADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPP 117
GG + +IA + N ++TM+H+TC E I L+ K+ G++N+LALRGD
Sbjct: 74 GGDKITSSTKIAGTVLNYCSLDTMLHMTCVKQTEETIKKNLEKTKNLGIRNILALRGD-- 131
Query: 118 HGQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNE 177
+ + TEGGF DLV+ I+ +YGDYF I VAGYP HPD+ +YQ +
Sbjct: 132 -ADENWGITEGGFNYGVDLVRFIKKEYGDYFSICVAGYPNGHPDST---------SYQED 181
Query: 178 LTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTG 237
L +LK K+DAG + ++TQLF+ D FL FV DC +IGITCPI+PGI PI + +++T
Sbjct: 182 LLHLKEKIDAGGEFVITQLFFTADEFLTFVKDCREIGITCPIIPGIFPIQTNRSLVQLTK 241
Query: 238 FCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSAL 296
K IP EI +EPIKDN+ A++ YGI L T+MCR +L G + LH+YTLN+E + +
Sbjct: 242 LSKLTIPEEIQKVIEPIKDNDAAIRKYGIDLATDMCRSLLNSGEVHGLHMYTLNLEAATI 301
Query: 297 AILTSLGLIEESKISRSLPWRRPTN-VFRVREDVRPIFWANRPKSYISRTIGWDQYPHGR 355
IL +LGL + ++++LPW+ N R E VRPIFW +RPKSYI RT WD++P+GR
Sbjct: 302 QILKNLGLWCQD-VAKTLPWKTSGNPERRENETVRPIFWTDRPKSYIHRTQKWDEFPNGR 360
Query: 356 WGDSGNPSYGALTDYQ--FMRPRARDKKLTEEWAVPLRSIEDIYVV 399
WGDS +P++G L DY F+R R +L +W L S D++ V
Sbjct: 361 WGDSASPAFGELRDYHLFFLRCRTSKDRLRAQWGKELTSETDVWKV 406
>B0V153_DANRE (tr|B0V153) Methylenetetrahydrofolate reductase OS=Danio rerio
GN=mthfr PE=3 SV=1
Length = 656
Score = 353 bits (907), Expect = 5e-95, Method: Compositional matrix adjust.
Identities = 186/392 (47%), Positives = 246/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM + P F DITW G GS + + + IA+ N
Sbjct: 60 FSLEFFPPRTSSGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N EKI + L K GL+N++ALRGDP G+D +V+ +GGF A D
Sbjct: 120 CGLESVLHLTCCNQTKEKITDHLNKAKRLGLKNIMALRGDPV-GED-WVEEDGGFNFATD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++ DYF I VAGYP HP+A E+Y+++L +LK KVDAGA IVTQ
Sbjct: 178 LVKHIRHEFDDYFDICVAGYPTGHPEA---------ESYEDDLRHLKEKVDAGAHFIVTQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKFV DC IGITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFRAETFLKFVKDCRAIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPEEIKQVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI EMC+ +LA G + LH YTLN E + + +L LGL E R L
Sbjct: 289 DNDAAIRNYGIQQAVEMCKVLLASGEVSGLHFYTLNREVATMEVLRQLGLWAEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD +P+GRWG+S +P++G LTDY +
Sbjct: 348 PWAISAHPKRKVEDVRPIFWASRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELTDYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E +Y V Y+
Sbjct: 408 LKSKSPKEALLQMWGEELMSEESVYEVFTNYI 439
>G9MZ58_HYPVG (tr|G9MZ58) Methylenetetrahydrofolate reductase OS=Hypocrea virens
(strain Gv29-8 / FGSC 10586) GN=TRIVIDRAFT_90038 PE=3
SV=1
Length = 597
Score = 353 bits (906), Expect = 7e-95, Method: Compositional matrix adjust.
Identities = 176/388 (45%), Positives = 249/388 (64%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM + P F DITWGAGG+ A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMDSFGPKFIDITWGAGGNIAELTCEMVVQAQAVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M ++K+++ALQ G N+LALRGDPP Q+ + +G F ARDLVKH
Sbjct: 78 TCMHLTCTDMGLDKVNDALQKAYKAGCTNILALRGDPPRDQESWTAADGNFRYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGYPE G + ++ L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYPE---------GCDDNKDEESLLDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + ++P E M LEP+K+++
Sbjct: 189 ADNFIRWVGKVRERGITVPILPGIMPIATYASFLRRAKHMQCRVPPEWMTLLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L E+CRK+LA+GI LH YT+N+ ++ +L L E+ + ++LPW+
Sbjct: 249 AVREIGKTLVAELCRKLLANGIHHLHFYTMNLAQATRMVLDELNWTPSPENPLKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSKGFGRRDEDVRPIFWRNRNKSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ ++W P S++DI + YL+
Sbjct: 368 TNEQNRKKWGEPT-SLQDIANTFVKYLE 394
>Q2H0T7_CHAGB (tr|Q2H0T7) Methylenetetrahydrofolate reductase OS=Chaetomium
globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 /
NBRC 6347 / NRRL 1970) GN=CHGG_04609 PE=3 SV=1
Length = 616
Score = 353 bits (905), Expect = 8e-95, Method: Compositional matrix adjust.
Identities = 180/394 (45%), Positives = 247/394 (62%), Gaps = 13/394 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYNFGPKFVDITWGAGGRIAELTCEMVVQAQTYLGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
+HLTCT+M EK+++AL+ G N+LALRGDPP Q+K+ TEGGF ARDLV H
Sbjct: 78 ACMHLTCTDMGEEKVNDALRKAYKAGCTNILALRGDPPREQEKWEATEGGFQYARDLVGH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKTYGNHFDIGVAGYPEGCDDNKDEDSL---------LDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PIVPGIMPI Y F+R K+P E MA LE +K+++
Sbjct: 189 ADNFIRWVGRVRERGITVPIVPGIMPIATYASFLRRANHMNCKVPEEWMAKLESVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L +MCRKIL+ GI+ LH YT+N+ ++ +L L + + + ++LPW+
Sbjct: 249 AVRDIGKTLVADMCRKILSAGIRHLHFYTMNLAQATRMVLEELDWLPSPDRPLKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGFGRRDEDVRPIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGVGLTGS 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQYCYSFL 411
++ ++W P SI+DI + + YL +L
Sbjct: 369 NEQN-RKKWGEPT-SIKDIANLFVRYLNKEIEYL 400
>H1VMU2_COLHI (tr|H1VMU2) Methylenetetrahydrofolate reductase OS=Colletotrichum
higginsianum (strain IMI 349063) GN=CH063_02618 PE=3
SV=1
Length = 614
Score = 353 bits (905), Expect = 1e-94, Method: Compositional matrix adjust.
Identities = 180/388 (46%), Positives = 248/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q+I +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVLQAQSIYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M +EK+++AL+ G N+LALRGDPP Q+K+ T+ GF A+DLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALRKAYKAGCTNILALRGDPPREQEKWEATDDGFRYAKDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA Y D+F I VAGYPE G + + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPE---------GCDDNKDEEQLLDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GI PI+PGIMPI Y FIR K+P + MAALEPIK+++
Sbjct: 189 GDNFVRWVGKVRERGINVPIIPGIMPIATYASFIRRAKHMNCKVPDDWMAALEPIKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L +MCRKI+A GI LH YT+N+ ++ +L L + S + +LPW+
Sbjct: 249 AVREVGKGLVADMCRKIVAAGIHHLHFYTMNLAQATRMVLEELNWMPTSDRPVKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW R KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLAHGRREEDVRPIFWKGRNKSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ ++W P RSI+D+ + + YL+
Sbjct: 368 TNEQNRKKWGEP-RSIKDVANIFVRYLE 394
>H2S3I1_TAKRU (tr|H2S3I1) Methylenetetrahydrofolate reductase OS=Takifugu
rubripes GN=LOC101078210 PE=3 SV=1
Length = 514
Score = 353 bits (905), Expect = 1e-94, Method: Compositional matrix adjust.
Identities = 184/392 (46%), Positives = 246/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM + P F DITW G GS + + + IA+ N
Sbjct: 64 FSLEFFPPRTASGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 123
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N +KI L K GL+N++ALRGDP G D + + EGGF A D
Sbjct: 124 CGLESILHLTCCNQTKDKITGYLGKAKHLGLKNIMALRGDPV-GAD-WEEEEGGFNYAVD 181
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ DYF I VAGYP HP+A E+YQ +L +LK KVDAGAD ++TQ
Sbjct: 182 LVKHIRSEFDDYFDICVAGYPTGHPEA---------ESYQQDLRHLKEKVDAGADFVITQ 232
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKF++DC IGITCPI+PGI PI Y+ ++ K ++P EI + LEPIK
Sbjct: 233 LFFRAETFLKFLDDCRTIGITCPILPGIFPIQGYQSLRQLVKLSKLEVPEEITSILEPIK 292
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L EMCR +L G + LH YTLN E + + +L LGL E R L
Sbjct: 293 DNDAAIRNYGIQLAVEMCRVLLDSGKVPGLHFYTLNREVATMEVLRQLGLWTEDP-RRPL 351
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD +P+GRWG+S +P++G L DY +
Sbjct: 352 PWAVSAHPKRKVEDVRPIFWASRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELNDYYLFY 411
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E ++ V Y+
Sbjct: 412 LKSKSSKEALLQMWGEELLSEESVFEVFTFYI 443
>E3QQT1_COLGM (tr|E3QQT1) Methylenetetrahydrofolate reductase OS=Colletotrichum
graminicola (strain M1.001 / M2 / FGSC 10212)
GN=GLRG_08363 PE=3 SV=1
Length = 619
Score = 352 bits (904), Expect = 1e-94, Method: Compositional matrix adjust.
Identities = 180/388 (46%), Positives = 246/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q+I +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVLQAQSIYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M +EK+++AL+ G N+LALRGDPP +K+ TE GF A+DLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALRKAYKAGCTNILALRGDPPREHEKWEATEDGFRYAKDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IRA Y D+F I VAGYPE G + + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRATYHDHFDIGVAGYPE---------GCDDNKDEEQLLDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R K+P MAALEPIK+++
Sbjct: 189 GDNFVRWVGKVRERGITVPIIPGIMPIATYSSFLRRAKHMNCKVPDAWMAALEPIKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L +MCRKI+A GI LH YT+N+ ++ +L L + S + +LPW+
Sbjct: 249 AVREVGKGLVADMCRKIVAAGIHHLHFYTMNLAQATRMVLEELNWMPTSDRPVKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW R KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLAHGRREEDVRPIFWKGRNKSYVLRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ ++W P +SI DI + + YL+
Sbjct: 368 TNEQNRKKWGEP-KSISDIATIFVRYLE 394
>G0RA43_HYPJQ (tr|G0RA43) Methylenetetrahydrofolate reductase OS=Hypocrea
jecorina (strain QM6a) GN=TRIREDRAFT_55055 PE=3 SV=1
Length = 604
Score = 352 bits (903), Expect = 1e-94, Method: Compositional matrix adjust.
Identities = 178/388 (45%), Positives = 244/388 (62%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMNNFGPKFIDITWGAGGGIAELTCEMVVQAQAVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M +EK+++ALQ G N+LALRGDPP Q + +G F ARDLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALQKAYKAGCTNILALRGDPPRDQTSWKAADGNFQYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYPEGCDDNKDEDQL---------LDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + +IP + MA LEP+K+++
Sbjct: 189 ADNFIRWVGRVRERGITVPILPGIMPIATYASFLRRAKHMQCRIPPDWMAKLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L ++CRK+LA+GI LH YT+N+ ++ +L L E + + LPW+
Sbjct: 249 AVREIGKTLVADLCRKLLANGIHHLHFYTMNLAQATRMVLDELNWTPSPERPLKQPLPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSKGFGRRDEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ ++W P +S++DI + YL+
Sbjct: 368 TNESNRKKWGEP-KSVQDIATTFVQYLE 394
>G2R3H5_THITE (tr|G2R3H5) Methylenetetrahydrofolate reductase OS=Thielavia
terrestris (strain ATCC 38088 / NRRL 8126)
GN=THITE_2115191 PE=3 SV=1
Length = 615
Score = 352 bits (903), Expect = 1e-94, Method: Compositional matrix adjust.
Identities = 177/383 (46%), Positives = 245/383 (63%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYNFGPKFIDITWGAGGRVAELTCEMVVQAQTYLGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
+HLTCT+M E++++AL+ G N+LALRGDPP ++K+ TEGGF ARDLV H
Sbjct: 78 ACMHLTCTDMGEERVNDALRKAYKAGCTNILALRGDPPRDKEKWEATEGGFRYARDLVAH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKTYGNHFDIGVAGYPEGCDDNQDEDLL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL++V + GIT PIVPGIMPI Y F+R K KIP + +A LEP+K+++
Sbjct: 189 VDNFLRWVGRVRERGITVPIVPGIMPIATYASFLRRANHMKCKIPDDWLAKLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L +MCRKILA GI+ LH YT+N+ ++ +L L + + + ++LPW+
Sbjct: 249 AVRDIGKTLVADMCRKILAAGIRHLHFYTMNLAQATRMVLEELDWLPSPDRPLKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGFGRRGEDVRPIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGS 368
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
++ ++W P +R I +++V
Sbjct: 369 NEQN-RKKWGEPTCIRDIANLFV 390
>R4XG29_9ASCO (tr|R4XG29) Methylenetetrahydrofolate reductase OS=Taphrina
deformans PYCC 5710 GN=TAPDE_003676 PE=4 SV=1
Length = 576
Score = 352 bits (903), Expect = 1e-94, Method: Compositional matrix adjust.
Identities = 172/376 (45%), Positives = 246/376 (65%), Gaps = 16/376 (4%)
Query: 33 VDNLFERMDRMVAHNPS-FCDITWGAGGSTADVTLEIANKMQNIVCVETMIHLTCTNMPV 91
+ NL++RM+RM + P F D+TWGAGG A++T ++ Q + ++T +HL CT MP
Sbjct: 1 MQNLYDRMERMASWGPPLFVDVTWGAGGRLAELTTDMVQTAQEMFGLDTCMHLICTGMPS 60
Query: 92 EKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKHIRAKYGDYFGIT 151
EK+ AL+ +G QN+LALRGDPP Q+K+ TEGGF A DLVK+IRA+YGDYF I
Sbjct: 61 EKVKEALKDAYDSGCQNILALRGDPPREQEKWEATEGGFRYATDLVKYIRAEYGDYFDIG 120
Query: 152 VAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCL 211
VAGY E HP+ + + QN + +LK K+DAGA+ +VTQ+FYD DIFL +V DC
Sbjct: 121 VAGYSEGHPECL--------DKSQN-INHLKEKIDAGANFVVTQMFYDVDIFLSWVQDCR 171
Query: 212 QIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTE 271
+ G+ PI+PGIMPI + F+R + + IP + ALEP+K+++ AV+ G L TE
Sbjct: 172 KAGVLVPIIPGIMPITGWDSFLRRAKWSEAHIPQHFLDALEPVKNDDAAVRERGTELLTE 231
Query: 272 MCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVREDVRP 331
MC+ IL G+ LH YT+N+EK+ I+ +LGL+++ + R +PW+R + R E VRP
Sbjct: 232 MCQTILDSGLHHLHFYTMNLEKATNMIIEALGLLKDVQ-KREMPWQRSLGLNRKDESVRP 290
Query: 332 IFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLR 391
IFWANR KSYI+RT WD++P+GRWGDS +P++G L +Y + R +++ + W P
Sbjct: 291 IFWANRHKSYIARTKEWDEFPNGRWGDSRSPAFGELENYN-IGLRVPPEEVPKLWGSP-- 347
Query: 392 SIEDIYVVGLLYLQYC 407
E + V L+ YC
Sbjct: 348 --ETLQDVADLFSNYC 361
>R7YW82_9EURO (tr|R7YW82) Methylenetetrahydrofolate reductase (NADPH)
OS=Coniosporium apollinis CBS 100218 GN=W97_05307 PE=4
SV=1
Length = 661
Score = 352 bits (903), Expect = 2e-94, Method: Compositional matrix adjust.
Identities = 174/388 (44%), Positives = 248/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
+SFEFFPPKT GV NL++RMDRM PSF D+TWGAGG + +T E+ Q+ +E
Sbjct: 18 YSFEFFPPKTAQGVQNLYDRMDRMHGFGPSFIDVTWGAGGRHSQLTCEMVKTAQSAYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M KID+AL+ + G N+LALRGDPP ++K+ GGF A+DLVK+
Sbjct: 78 TCMHLTCTDMDKSKIDDALREAYNAGCTNILALRGDPPREREKWEAKAGGFRYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
I+ KYG++F I VAGY E D +D + + +LK KVDAG ++TQ+FYD
Sbjct: 138 IKEKYGNHFDIGVAGYSEGCEDQEDADLL---------IDHLKEKVDAGGTFVITQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
DIFL +V C GIT PI+PGIMPI+ Y F+R + K +P E ALEP+K+++
Sbjct: 189 VDIFLDWVKKCRAKGITVPIIPGIMPIHTYAAFLRRAHWTKCHVPEEWTKALEPVKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSLPWR 317
V+ G L +MCR++L GI LH YT+N+ ++ +L LG+ ES + + LPWR
Sbjct: 249 EVREVGKDLVAKMCRRLLDAGIIHLHFYTMNLAQATRMVLEELGITPDLESPLDKPLPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R E+VRPIFW NR +SY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLNRRDENVRPIFWRNRNRSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGIGL-KG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ + W P RS++DI + + Y+Q
Sbjct: 368 TNEQNVKLWGQP-RSVKDIANLFVRYMQ 394
>J8Q880_SACAR (tr|J8Q880) Methylenetetrahydrofolate reductase OS=Saccharomyces
arboricola (strain H-6 / AS 2.3317 / CBS 10644)
GN=SU7_1115 PE=3 SV=1
Length = 600
Score = 352 bits (902), Expect = 2e-94, Method: Compositional matrix adjust.
Identities = 184/414 (44%), Positives = 260/414 (62%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQQRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ + Q+++ +ET +HLTCTNMP+ ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVSTAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+ + Q EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DAESWTQVEGGFKYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPSKDS-------KLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + + G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYGAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ +IP E +A LEPIKD++E V+ G +L +MC+K+L G I LH+YT+N+EK+ L
Sbjct: 233 GQIRIPQEFLAQLEPIKDDDELVRDVGTNLIVQMCQKLLDSGYISHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLI-EESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R K E W+ P SI DI + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDIAFLVINYL 405
>H9MZH5_DANRE (tr|H9MZH5) Methylenetetrahydrofolate reductase OS=Danio rerio
GN=mthfr PE=2 SV=1
Length = 656
Score = 352 bits (902), Expect = 2e-94, Method: Compositional matrix adjust.
Identities = 185/392 (47%), Positives = 245/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM + P F DITW G GS + + + IA+ N
Sbjct: 60 FSLEFFPPRTSSGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N EKI + L K GL+N++ALRGDP G+D +V+ +GGF A D
Sbjct: 120 CGLESVLHLTCCNQTKEKITDHLNKAKRLGLKNIMALRGDPV-GED-WVEEDGGFNFATD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++ DYF I VAGYP HP+A E+Y+++L +LK KVDAGA IVTQ
Sbjct: 178 LVKHIRHEFDDYFDICVAGYPTGHPEA---------ESYEDDLRHLKEKVDAGAHFIVTQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKFV DC IGITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFRAETFLKFVKDCRAIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPEEIKQVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI EMC+ +LA G + LH Y LN E + + +L LGL E R L
Sbjct: 289 DNDAAIRNYGIQQAVEMCKVLLASGEVSGLHFYPLNREVATMEVLRQLGLWAEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD +P+GRWG+S +P++G LTDY +
Sbjct: 348 PWAISAHPKRKVEDVRPIFWASRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELTDYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E +Y V Y+
Sbjct: 408 LKSKSPKEALLQMWGEELMSEESVYEVFTNYI 439
>G1X9G2_ARTOA (tr|G1X9G2) Methylenetetrahydrofolate reductase OS=Arthrobotrys
oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)
GN=AOL_s00076g269 PE=3 SV=1
Length = 623
Score = 351 bits (901), Expect = 3e-94, Method: Compositional matrix adjust.
Identities = 176/383 (45%), Positives = 242/383 (63%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE++ PKT GV NL++RM+RM + P F DITW AGG +++T E+ N Q + +E
Sbjct: 18 FSFEYYVPKTAQGVQNLYDRMERMGSFGPQFIDITWNAGGRLSNLTTEMVNVAQTVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT M EK+DNALQ + G N+LALRGDPP +K+ GGF A+DLVKH
Sbjct: 78 TCMHLTCTGMEKEKVDNALQEAYNGGCTNILALRGDPPRENEKWSAVPGGFRYAKDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYGDYF I VAGYPE D + D + L +LK K+DAG I+TQ+FYD
Sbjct: 138 IREKYGDYFDIGVAGYPEGCDDEVDPDIL---------LDHLKEKIDAGGTFIITQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
DIFL +VN GIT PI+PGIMPI+ Y FIR + K +P + + LEP+K+++
Sbjct: 189 VDIFLDWVNKVRAKGITVPIIPGIMPIHTYAAFIRRATWTKIHVPEKWLEVLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSLPWR 317
AV+ G L E+C+KILA GI LH YT+N+ + +L L L+ E++ +LP++
Sbjct: 249 AVRDIGRDLVVELCKKILAAGINQLHFYTMNLATATRMVLEGLELMPSLEARELPALPFK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R E+VRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y
Sbjct: 309 SSLGLGRREENVRPIFWKNRHKSYVARTQEWDEFPNGRWGDSRSPAFGELDTYGIALKGT 368
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
++ + + W P + I D++V
Sbjct: 369 TEQNI-KLWGRPETVAEIADLFV 390
>M7SPP9_9PEZI (tr|M7SPP9) Putative methylenetetrahydrofolate reductase 1 protein
OS=Eutypa lata UCREL1 GN=UCREL1_6847 PE=4 SV=1
Length = 620
Score = 351 bits (900), Expect = 3e-94, Method: Compositional matrix adjust.
Identities = 179/388 (46%), Positives = 247/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++R++RM P F DITWGAGG A++T E+ + Q +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRIERMYDFGPKFIDITWGAGGRIAELTCEMVVQAQTYFGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M EK+++AL G N+LALRGDPP ++K++ TE F ARDLV H
Sbjct: 78 TCMHLTCTDMGEEKVNDALAKAYKAGCTNILALRGDPPREKEKWIATEDNFQYARDLVAH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR KYG++FGI VAGYPE G + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRNKYGNHFGIGVAGYPE---------GCDDNKDEGQLLDHLKEKVDMGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F++++ + GIT PI+PGIMPI Y FIR K+P M ALEPIK+++
Sbjct: 189 ADNFVRWMGKVRERGITVPILPGIMPIATYASFIRRANHMNCKVPDGWMEALEPIKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKISR--SLPWR 317
AV+ G L ++CRKI+A GI LH YT+N+ ++ +L L + S R +LPW+
Sbjct: 249 AVRNVGKSLVADLCRKIMAAGIVHLHFYTMNLAQATRMVLEELDWMPTSNRPRKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ ++ R EDVRPIFW NR KSYISRT+ WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLSLGRREEDVRPIFWRNRNKSYISRTMDWDEFPNGRWGDSRSPAFGELDAYG-IGLTG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ ++W P +S++DI + + Y+Q
Sbjct: 368 TNESNRKKWGEP-QSVKDIANLFVRYIQ 394
>R7UHV3_9ANNE (tr|R7UHV3) Uncharacterized protein OS=Capitella teleta
GN=CAPTEDRAFT_181552 PE=4 SV=1
Length = 654
Score = 350 bits (899), Expect = 4e-94, Method: Compositional matrix adjust.
Identities = 174/392 (44%), Positives = 247/392 (63%), Gaps = 18/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM P FCDITW G + IAN M N
Sbjct: 55 FSLEFFPPRTANGAVNLISRFDRMAMGRPLFCDITWHPAGDPGSDKPTSSTSIANSMVNY 114
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ETM+H+TC + ++I N L K+ G++N+LALRGDPP G +++ E GF D
Sbjct: 115 CGLETMLHITCCGLTKQQITNHLTKAKNLGIRNILALRGDPP-GDEEWKAPEDGFNFGTD 173
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LV+HIR +GD+F I VAGYP HPD + +Y+ +L ++K KVDAGAD I+TQ
Sbjct: 174 LVRHIREVFGDHFVIAVAGYPTGHPD---------SPSYEEDLQHMKEKVDAGADFIITQ 224
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLK+V+DC IGI+ PI+PGI+PI Y+ + + ++P +I+ + PIK
Sbjct: 225 LFFKAETFLKYVSDCRAIGISVPIMPGILPIQAYQSLRHIVKLSRLEVPDDIIDTITPIK 284
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+EA++ YGI TEMCR +L G I LH YTLN E + + +L +LG+ E RSL
Sbjct: 285 DNDEAIRNYGIFQATEMCRDLLDSGSIHGLHFYTLNREVATIQVLKALGMWCEDP-RRSL 343
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW+ N R +EDVRPIFW+ RP+SY+ RT WD++P+GRWG+S + ++ L+DY +
Sbjct: 344 PWKTTANHNRCKEDVRPIFWSARPQSYVYRTSEWDEFPNGRWGNSASAAFRDLSDYYLFY 403
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ RA ++L + W L+ +D++ V YL
Sbjct: 404 LKSRAPKEELLKMWGEELKCEKDVFGVFERYL 435
>R1GCB8_9PEZI (tr|R1GCB8) Putative methylenetetrahydrofolate reductase protein
OS=Neofusicoccum parvum UCRNP2 GN=UCRNP2_9800 PE=4 SV=1
Length = 637
Score = 350 bits (899), Expect = 5e-94, Method: Compositional matrix adjust.
Identities = 176/388 (45%), Positives = 247/388 (63%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFEFFPPKT GV NL++RMDRM P+F D+TWGAGG + +T E+ Q++ +E
Sbjct: 18 FSFEFFPPKTAQGVQNLYDRMDRMHGLGPTFIDVTWGAGGRNSTLTCEMVKVAQSVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M K+D AL+ + G +N+LALRGDPP ++K+ T GGF A+DLVK+
Sbjct: 78 TCMHLTCTDMEKTKLDEALREAYNAGCKNILALRGDPPREKEKWEATAGGFRYAKDLVKY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGY E D D + L +LK KVDAG IVTQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYSEGCEDQEDPDLL---------LDHLKEKVDAGGTFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
DIFL +V GI PIVPGIMPIN Y F+R + K +P + + AL+PIK+++
Sbjct: 189 VDIFLDWVKKVRAKGIDVPIVPGIMPINTYAAFMRRATWTKCHVPPDWLKALDPIKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSLPWR 317
V+ G HL MCR+++ GI LH YT+N+ +S +L LGL +S + + LPWR
Sbjct: 249 EVREIGKHLIATMCRRLMEAGILHLHFYTMNLAQSTRMVLEELGLTPDIQSPLEKPLPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ R E+VRPIFW NR +SY+ RT WD++P+GRWGDS +P++G L Y + +
Sbjct: 309 QSLAPGRREENVRPIFWRNRNRSYVVRTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLKG 367
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ + W +P +S++DI + + Y++
Sbjct: 368 TNEQNIKLWGMP-KSVQDISNLFVRYME 394
>L7JK78_MAGOR (tr|L7JK78) Methylenetetrahydrofolate reductase OS=Magnaporthe
oryzae P131 GN=OOW_P131scaffold00244g12 PE=3 SV=1
Length = 631
Score = 350 bits (898), Expect = 5e-94, Method: Compositional matrix adjust.
Identities = 178/390 (45%), Positives = 242/390 (62%), Gaps = 17/390 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVTQAQTYFGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP ++K+ + GF A+DLV H
Sbjct: 78 TCMHLTCTDMGVEKVNDALSKAYKAGCTNILALRGDPPRDKEKWEAAQDGFNYAKDLVSH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKTYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + +IP E + LEPIK ++
Sbjct: 189 ADNFVRWVGRVRERGITVPIIPGIMPIATYASFLRRANHMQARIPEEWLQRLEPIKTDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV++ G L E+CRKILA GI LH YT+N+ +S IL L + + +LPW+
Sbjct: 249 AVRIVGRQLVVELCRKILAAGIHHLHFYTMNLAQSTALILEDLDWLPSPNKPLKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY--QFMRP 375
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWRNRNKSYVMRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLLGT 368
Query: 376 RARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++K E +S++DI + + Y+Q
Sbjct: 369 NEQNRKKFGE----PKSVKDIATLFVRYVQ 394
>L7IB80_MAGOR (tr|L7IB80) Methylenetetrahydrofolate reductase OS=Magnaporthe
oryzae Y34 GN=OOU_Y34scaffold00433g28 PE=3 SV=1
Length = 631
Score = 350 bits (898), Expect = 5e-94, Method: Compositional matrix adjust.
Identities = 178/390 (45%), Positives = 242/390 (62%), Gaps = 17/390 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVTQAQTYFGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP ++K+ + GF A+DLV H
Sbjct: 78 TCMHLTCTDMGVEKVNDALSKAYKAGCTNILALRGDPPRDKEKWEAAQDGFNYAKDLVSH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKTYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + +IP E + LEPIK ++
Sbjct: 189 ADNFVRWVGRVRERGITVPIIPGIMPIATYASFLRRANHMQARIPEEWLQRLEPIKTDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV++ G L E+CRKILA GI LH YT+N+ +S IL L + + +LPW+
Sbjct: 249 AVRIVGRQLVVELCRKILAAGIHHLHFYTMNLAQSTALILEDLDWLPSPNKPLKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY--QFMRP 375
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWRNRNKSYVMRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLLGT 368
Query: 376 RARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++K E +S++DI + + Y+Q
Sbjct: 369 NEQNRKKFGE----PKSVKDIATLFVRYVQ 394
>G4MV96_MAGO7 (tr|G4MV96) Methylenetetrahydrofolate reductase OS=Magnaporthe
oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
GN=MGG_01728 PE=3 SV=1
Length = 631
Score = 350 bits (898), Expect = 5e-94, Method: Compositional matrix adjust.
Identities = 178/390 (45%), Positives = 242/390 (62%), Gaps = 17/390 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYHFGPKFIDITWGAGGRIAELTCEMVTQAQTYFGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M VEK+++AL G N+LALRGDPP ++K+ + GF A+DLV H
Sbjct: 78 TCMHLTCTDMGVEKVNDALSKAYKAGCTNILALRGDPPRDKEKWEAAQDGFNYAKDLVSH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKTYGDHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V + GIT PI+PGIMPI Y F+R + +IP E + LEPIK ++
Sbjct: 189 ADNFVRWVGRVRERGITVPIIPGIMPIATYASFLRRANHMQARIPEEWLQRLEPIKTDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV++ G L E+CRKILA GI LH YT+N+ +S IL L + + +LPW+
Sbjct: 249 AVRIVGRQLVVELCRKILAAGIHHLHFYTMNLAQSTALILEDLDWLPSPNKPLKHALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY--QFMRP 375
+ + R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWRNRNKSYVMRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLLGT 368
Query: 376 RARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++K E +S++DI + + Y+Q
Sbjct: 369 NEQNRKKFGE----PKSVKDIATLFVRYVQ 394
>B8BRT9_THAPS (tr|B8BRT9) Methylenetetrahydrofolate reductase (Fragment)
OS=Thalassiosira pseudonana GN=THAPSDRAFT_13444 PE=3
SV=1
Length = 574
Score = 350 bits (898), Expect = 6e-94, Method: Compositional matrix adjust.
Identities = 172/363 (47%), Positives = 240/363 (66%), Gaps = 19/363 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAH-NPSFCDITWGAGGSTADVTLEIANKMQNIVCV 78
+SFEFFPPKTE G+DNL R+DRM +P F ITWG+ GST TL +A+ Q CV
Sbjct: 1 YSFEFFPPKTEPGLDNLLTRIDRMCRRLDPLFVSITWGSNGSTLSRTLAVASHAQRFACV 60
Query: 79 ETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTE-GGFACAR--D 135
+ ++HL+CT + E+I + L KS+G+ N+LALRGDPP G+ + + + G C R D
Sbjct: 61 DVLLHLSCTGLTREQIGHVLAMAKSSGVHNILALRGDPPQGKRAWKEGDVSGGECDRAID 120
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAI-GSDGVATTEAYQNELTYLKSKVDAGADLIVT 194
LVK IR +G+YFGI VAG+PE HP + G +G A E+ +LK K+DAGAD +++
Sbjct: 121 LVKLIRRLHGNYFGIGVAGHPEGHPSSQKGDNGKAL------EMQHLKEKLDAGADFVIS 174
Query: 195 QLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPI 254
Q FYD ++FL +V C ++GI CPI+PGIMP+ +Y ++MT FC +P+ +M L I
Sbjct: 175 QFFYDVNVFLDYVKRCRKVGIDCPIIPGIMPVQSYSSLVKMTQFCGISVPSAVMDRLSNI 234
Query: 255 KDNEEAVKLYGIHLGTEMCRKILAHGIKT----LHLYTLNMEKSALAILTSLGLIEESKI 310
+ ++EAVK G + EMC +IL+ G++ H YTLN+E+S ILTSLG S+
Sbjct: 235 RLDDEAVKQVGCKIVAEMCEQILSAGLEVDVDGFHFYTLNLERSTTRILTSLGAGSISEQ 294
Query: 311 SRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGA 366
+RS LPW+ R +EDVRPI W+NRPKSY+ RT WD++P+GRWGDS +P++G
Sbjct: 295 ARSTRRVLPWKPSAMENRSKEDVRPINWSNRPKSYVMRTDDWDEFPNGRWGDSTSPAFGE 354
Query: 367 LTD 369
L+D
Sbjct: 355 LSD 357
>G9P292_HYPAI (tr|G9P292) Methylenetetrahydrofolate reductase OS=Hypocrea
atroviridis (strain ATCC 20476 / IMI 206040)
GN=TRIATDRAFT_33767 PE=3 SV=1
Length = 597
Score = 350 bits (898), Expect = 6e-94, Method: Compositional matrix adjust.
Identities = 172/353 (48%), Positives = 226/353 (64%), Gaps = 11/353 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RMDRM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMDRMNNFGPKFIDITWGAGGGIAELTCEMVVQAQAVYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M +EK+++ALQ G N+LALRGDPP Q + +G F ARDLVKH
Sbjct: 78 TCMHLTCTDMGLEKVNDALQKAYKAGCTNILALRGDPPRDQTTWTAADGNFRYARDLVKH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YGD+F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRDTYGDHFDIGVAGYPEGCDDNKDEDSL---------LDHLKEKVDMGAGFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL++V + GIT PI+PGIMPI Y F+R + ++P E M LEP+K+++
Sbjct: 189 ADNFLRWVGRVRERGITVPILPGIMPIATYASFLRRAKHMQCRVPPEWMTLLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L E+CRK+LA GI LH YT+N+ ++ +L L E + ++LPW+
Sbjct: 249 AVREIGKTLVAELCRKLLAGGIHHLHFYTMNLAQAVRMVLDELDWTPSAERPLKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY 370
+ R EDVRPIFW NR KSY+ RT WD++P+GRWGDS +P++G L Y
Sbjct: 309 QSKGFGRREEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAY 361
>G2Q3E8_THIHA (tr|G2Q3E8) Methylenetetrahydrofolate reductase OS=Thielavia
heterothallica (strain ATCC 42464 / BCRC 31852 / DSM
1799) GN=MYCTH_2314160 PE=3 SV=1
Length = 612
Score = 350 bits (898), Expect = 6e-94, Method: Compositional matrix adjust.
Identities = 177/383 (46%), Positives = 245/383 (63%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTAQGVQNLYDRMERMYNFGPKFIDITWGAGGRIAELTCEMVVQAQTYLGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
+HLTCT+M EK+++AL+ G N+LALRGDPP ++K+ T+ F ARDLV H
Sbjct: 78 ACMHLTCTDMGEEKVNDALRKAYKAGCTNILALRGDPPRDKEKWEATDTKFRYARDLVAH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE D D + L +LK KVD GA IVTQ+FYD
Sbjct: 138 IRKMYGNHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDMGASFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D FL++V + GIT PIVPGIMPI Y F+R KIP E MA LEP+K+++
Sbjct: 189 VDNFLRWVGKVRERGITVPIVPGIMPIATYASFLRRANHMNCKIPEEWMAKLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L +MCRKILA GI+ LH YT+N+ ++ +L L + E + ++LPW+
Sbjct: 249 AVRDIGKVLVADMCRKILAAGIRHLHFYTMNLAQATRMVLEELDWLPSPERPLKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y + +
Sbjct: 309 QSLGLGRRTEDVRPIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYG-IGLKG 367
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
+++ ++W P +R I +++V
Sbjct: 368 TNEQNRQKWGEPTCVRDIANLFV 390
>C5E412_ZYGRC (tr|C5E412) Methylenetetrahydrofolate reductase
OS=Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732
/ NBRC 1130 / NCYC 568 / NRRL Y-229) GN=ZYRO0E01870g
PE=3 SV=1
Length = 599
Score = 349 bits (896), Expect = 1e-93, Method: Compositional matrix adjust.
Identities = 181/415 (43%), Positives = 255/415 (61%), Gaps = 20/415 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHN-PSFCDITWGAGG 59
M++ EK++ + FSFE+F PKT GV NL++RMDRM P F D+TW AGG
Sbjct: 1 MRISEKLQNHRSKST-KPTFSFEYFVPKTTQGVQNLYDRMDRMYQSTLPQFIDVTWNAGG 59
Query: 60 ST-ADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ +T ++ Q+++ +ET +HLTCTNMPV +ID+AL++ + +G QN+LALRGDPP
Sbjct: 60 GVLSQLTTDLVETSQSVLGLETCMHLTCTNMPVSQIDDALESARLSGCQNILALRGDPPV 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
D + EGGF A+DLV++IR KYGDYF I VAGYPE HP+ G D + L
Sbjct: 120 NSDSWQPVEGGFQYAKDLVRYIRDKYGDYFDIGVAGYPEGHPETAGDD--------ETLL 171
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
+LK KVDAGA+ I+TQ+FYD D+F+K+ G+ P++PGIMPI Y F+R +
Sbjct: 172 DHLKEKVDAGANFIITQMFYDADLFIKWCQRVRAKGVDVPLIPGIMPITTYAAFLRRANW 231
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
C IP E L+PIKD+++ V+ G L +C+K+L G + LH+YT+N+EK+
Sbjct: 232 CDVHIPQEYFDRLDPIKDDDQLVREVGTDLIVSLCQKLLDSGYVSHLHIYTMNLEKAPQM 291
Query: 298 ILTSLGLIEESKISRS-----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL + L+ LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 292 ILDRMELLPSHDEPLDNHLAILPWRKSLNPQRRNEEVRPIFWQRRPYSYVARTSQWSVDE 351
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+P+GR+GDS +P++G L R KK E W+ P S+EDI + + YL+
Sbjct: 352 FPNGRFGDSSSPAFGDLDLCGASLIRQSGKKSLELWSAP-NSMEDIAQLVINYLR 405
>F7H2X2_CALJA (tr|F7H2X2) Methylenetetrahydrofolate reductase OS=Callithrix
jacchus GN=MTHFR PE=3 SV=1
Length = 656
Score = 349 bits (895), Expect = 1e-93, Method: Compositional matrix adjust.
Identities = 175/392 (44%), Positives = 244/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 60 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC + +E+I L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 120 CGLETILHMTCCHQRLEEITGHLHKAKQLGLKNILALRGDP--TGDQWEEEEGGFNHAVD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HPDA E+++ ++ +LK KV AGAD ++TQ
Sbjct: 178 LVKHIRSEFGDYFDICVAGYPKGHPDA---------ESFEADVKHLKEKVSAGADFVITQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F FV C +GITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFEADTFFHFVKACTDVGITCPILPGIFPIQGYHSLRQLVKLSKLELPQEIKDVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++LA G + LH YTLN E + +L LGL E R L
Sbjct: 289 DNDAAIRNYGIELAVSLCRELLASGLVPGLHFYTLNREVATTEVLKRLGLWTEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L +Y +
Sbjct: 348 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKNYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V + YL
Sbjct: 408 LKSKSPREELLKMWGEELPSEESVFEVFVHYL 439
>F7HIS1_CALJA (tr|F7HIS1) Methylenetetrahydrofolate reductase OS=Callithrix
jacchus GN=MTHFR PE=3 SV=1
Length = 697
Score = 349 bits (895), Expect = 1e-93, Method: Compositional matrix adjust.
Identities = 175/392 (44%), Positives = 244/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 101 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 160
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC + +E+I L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 161 CGLETILHMTCCHQRLEEITGHLHKAKQLGLKNILALRGDP--TGDQWEEEEGGFNHAVD 218
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HPDA E+++ ++ +LK KV AGAD ++TQ
Sbjct: 219 LVKHIRSEFGDYFDICVAGYPKGHPDA---------ESFEADVKHLKEKVSAGADFVITQ 269
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F FV C +GITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 270 LFFEADTFFHFVKACTDVGITCPILPGIFPIQGYHSLRQLVKLSKLELPQEIKDVIEPIK 329
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++LA G + LH YTLN E + +L LGL E R L
Sbjct: 330 DNDAAIRNYGIELAVSLCRELLASGLVPGLHFYTLNREVATTEVLKRLGLWTEDP-RRPL 388
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L +Y +
Sbjct: 389 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKNYYLFY 448
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V + YL
Sbjct: 449 LKSKSPREELLKMWGEELPSEESVFEVFVHYL 480
>K1QN08_CRAGI (tr|K1QN08) Methylenetetrahydrofolate reductase OS=Crassostrea
gigas GN=CGI_10025706 PE=3 SV=1
Length = 650
Score = 349 bits (895), Expect = 1e-93, Method: Compositional matrix adjust.
Identities = 173/396 (43%), Positives = 248/396 (62%), Gaps = 18/396 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVTLE--IANKMQN 74
+S EFFPP+T +G NL R++RM P FCDITW G G+T T +A M N
Sbjct: 50 YSLEFFPPRTANGAVNLVSRIERMSEGGPMFCDITWHPAGDPGNTEKPTSSTCMAATMLN 109
Query: 75 IVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACAR 134
VETM+H+TC+N + + LQ K GL+N+LALRGDPP G D + + E G A
Sbjct: 110 YCGVETMLHITCSNQDEDGLKRNLQKAKDIGLKNLLALRGDPPDGGDTWKKQEEGLNYAT 169
Query: 135 DLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVT 194
DLVK IR ++GD+F I VAGYP HP++ +Y ++L +LK KVDAGA+ I+T
Sbjct: 170 DLVKVIRREHGDHFTICVAGYPTGHPEST---------SYGDDLRHLKEKVDAGANFIIT 220
Query: 195 QLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPI 254
QLF+ + F +F+ DC +IGITCPI+PG++PI Y+ + + ++P EI+ +EPI
Sbjct: 221 QLFFKPETFFQFLRDCREIGITCPIIPGVLPIQAYQSLRHIVKLSRLEVPKEILDTIEPI 280
Query: 255 KDNEEAVKLYGIHLGTEMCRKILAH-GIKTLHLYTLNMEKSALAILTSLGLIEESKISRS 313
KDN+EA++ +G+ +MCR++L H + +H YTLN E + + IL LG+ E +
Sbjct: 281 KDNDEAIRNFGVEQCFQMCRELLKHEDVHGVHFYTLNREVATIEILRRLGMWVEEPC-KP 339
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW++ N R +EDVRPIFW +RPKSYI RT WD++P+GRWG+S S+G LTDY
Sbjct: 340 LPWKQTANYVRCKEDVRPIFWRSRPKSYIHRTSNWDEFPNGRWGNSSAASFGDLTDYYLF 399
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+++ + + L + W L S +D++ V Y+ C
Sbjct: 400 YLKHKTPKEDLLKMWGEELNSEQDVWDVFHCYISGC 435
>F6SM95_CALJA (tr|F6SM95) Methylenetetrahydrofolate reductase OS=Callithrix
jacchus GN=MTHFR PE=3 SV=1
Length = 679
Score = 348 bits (894), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 175/392 (44%), Positives = 244/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 83 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 142
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC + +E+I L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 143 CGLETILHMTCCHQRLEEITGHLHKAKQLGLKNILALRGDP--TGDQWEEEEGGFNHAVD 200
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HPDA E+++ ++ +LK KV AGAD ++TQ
Sbjct: 201 LVKHIRSEFGDYFDICVAGYPKGHPDA---------ESFEADVKHLKEKVSAGADFVITQ 251
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F FV C +GITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 252 LFFEADTFFHFVKACTDVGITCPILPGIFPIQGYHSLRQLVKLSKLELPQEIKDVIEPIK 311
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++LA G + LH YTLN E + +L LGL E R L
Sbjct: 312 DNDAAIRNYGIELAVSLCRELLASGLVPGLHFYTLNREVATTEVLKRLGLWTEDP-RRPL 370
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L +Y +
Sbjct: 371 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKNYYLFY 430
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V + YL
Sbjct: 431 LKSKSPREELLKMWGEELPSEESVFEVFVHYL 462
>Q5SNW6_HUMAN (tr|Q5SNW6) Methylenetetrahydrofolate reductase OS=Homo sapiens
GN=MTHFR PE=2 SV=1
Length = 697
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 245/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P + D+TW G ++ IA+ N
Sbjct: 101 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNY 160
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 161 CGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 218
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 219 LVKHIRSEFGDYFDICVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 269
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 270 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 329
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 330 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 388
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 389 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 448
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V +LYL
Sbjct: 449 LKSKSPKEELLKMWGEELTSEESVFEVFVLYL 480
>H0X153_OTOGA (tr|H0X153) Methylenetetrahydrofolate reductase OS=Otolemur
garnettii GN=MTHFR PE=3 SV=1
Length = 696
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 243/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAQGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 160 CGLETILHMTCCCQSQEEITGHLHKAKQLGLKNILALRGDP--TGDQWEEKEGGFNYAVD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++GDYF I VAGYP+ HP+A E+++ +L +LK+KV AGAD I+TQ
Sbjct: 218 LVKHIRNEFGDYFDICVAGYPKGHPEA---------ESFEADLKHLKAKVSAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++TD FL FV C +GITCPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFETDTFLHFVKACTDMGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQKIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 329 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 387
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 388 PWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 447
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V + YL
Sbjct: 448 LKSKSPKEELLKMWGEELTSEESVFDVFVHYL 479
>G3RAX7_GORGO (tr|G3RAX7) Methylenetetrahydrofolate reductase OS=Gorilla gorilla
gorilla GN=MTHFR PE=3 SV=1
Length = 697
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 245/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P + D+TW G ++ IA+ N
Sbjct: 101 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNY 160
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 161 CGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 218
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 219 LVKHIRSEFGDYFDICVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 269
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 270 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 329
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 330 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 388
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 389 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 448
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V +LYL
Sbjct: 449 LKSKSPKEELLKMWGEELTSEESVFEVFVLYL 480
>H2PY11_PANTR (tr|H2PY11) Methylenetetrahydrofolate reductase OS=Pan troglodytes
GN=MTHFR PE=2 SV=1
Length = 656
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 245/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P + D+TW G ++ IA+ N
Sbjct: 60 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 120 CGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 178 LVKHIRSEFGDYFDICVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 289 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 348 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V +LYL
Sbjct: 408 LKSKSPKEELLKMWGEELTSEESVFEVFVLYL 439
>G1SSR7_RABIT (tr|G1SSR7) Methylenetetrahydrofolate reductase OS=Oryctolagus
cuniculus GN=MTHFR PE=3 SV=1
Length = 655
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 179/392 (45%), Positives = 242/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G GS + + + IA+ N
Sbjct: 59 FSLEFFPPRTAQGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTAVNY 118
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ETM+H+TC E + L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 119 CGLETMLHMTCCRQRREDLTAHLHKAKQLGLKNILALRGDPVG--DQWEEEEGGFNYAVD 176
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HPDA E+ + +L +LK KV AGAD I+TQ
Sbjct: 177 LVKHIRSEFGDYFDICVAGYPKGHPDA---------ESLEADLKHLKEKVSAGADFIITQ 227
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ D F FVN C ++GITCPI+PGI PI Y ++ + ++P EI +EPIK
Sbjct: 228 LFFAADTFFSFVNACTEMGITCPILPGIFPIQGYHSLRQLVKLSRLEVPQEIKDVIEPIK 287
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LGL E R L
Sbjct: 288 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREVATTEVLKRLGLWTEDP-RRPL 346
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 347 PWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 406
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ + ++L + W L S E ++ V + YL
Sbjct: 407 LKSKCPREELLQMWGEELTSEESVFEVFVRYL 438
>K7DTF1_PANTR (tr|K7DTF1) Methylenetetrahydrofolate reductase OS=Pan troglodytes
GN=MTHFR PE=2 SV=1
Length = 656
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 245/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P + D+TW G ++ IA+ N
Sbjct: 60 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 120 CGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 178 LVKHIRSEFGDYFDICVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 289 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 348 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V +LYL
Sbjct: 408 LKSKSPKEELLKMWGEELTSEESVFEVFVLYL 439
>K7C2K2_PANTR (tr|K7C2K2) Methylenetetrahydrofolate reductase OS=Pan troglodytes
GN=MTHFR PE=2 SV=1
Length = 656
Score = 348 bits (893), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 245/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P + D+TW G ++ IA+ N
Sbjct: 60 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 120 CGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 178 LVKHIRSEFGDYFDICVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 289 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 348 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V +LYL
Sbjct: 408 LKSKSPKEELLKMWGEELTSEESVFEVFVLYL 439
>C5M851_CANTT (tr|C5M851) Methylenetetrahydrofolate reductase OS=Candida
tropicalis (strain ATCC MYA-3404 / T1) GN=CTRG_02573
PE=3 SV=1
Length = 609
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 183/412 (44%), Positives = 252/412 (61%), Gaps = 20/412 (4%)
Query: 1 MKVIEKV-RXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGG 59
MK+ EK+ + FSFEFF PKT GV NL++RMDRM NP F DITW AGG
Sbjct: 1 MKISEKLDQAHKAAHSPPATFSFEFFVPKTSQGVQNLYDRMDRMYDLNPIFIDITWNAGG 60
Query: 60 STADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHG 119
++ +T E+ Q+ + +ET +HLTCTNM VE ID AL +G QN+LALRGDPP
Sbjct: 61 RSSTLTNEMVYTAQSTLGLETCMHLTCTNMKVELIDEALDKAYKSGCQNILALRGDPPLD 120
Query: 120 QDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELT 179
++ G F A+DL+ +I KY ++F I VAGYPE HP+ +D + T E
Sbjct: 121 GS---ESTGDFKYAKDLIAYIHKKYENHFNIGVAGYPEGHPEE--TDELKTLE------- 168
Query: 180 YLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFC 239
YLK K DAGA+ I+TQ+FYD D F+ + + +IGI PI+PGIMPI+ Y F+R +
Sbjct: 169 YLKEKCDAGANFIITQMFYDADNFISWCSKLRKIGIDLPIIPGIMPISTYSAFLRRAKWS 228
Query: 240 KTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAI 298
+ IP + AL+PIKD++ V+ G L +EMC+K+L G I LH YT+N+EK+ + I
Sbjct: 229 EIAIPQHFLDALDPIKDDDYLVREKGTELVSEMCQKLLESGYINHLHFYTMNLEKATVMI 288
Query: 299 LTSLGLIEESKISR-----SLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPH 353
L L LIE K + LPWR+ N R +E +RPIFW NR SY++RT WD++P+
Sbjct: 289 LEKLNLIEAVKSNEIVGVTELPWRKSLNPERSKESIRPIFWQNRKYSYVTRTATWDEFPN 348
Query: 354 GRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
GRWGDS +P++G + R K+ E W +P ++I DI + + YL+
Sbjct: 349 GRWGDSRSPAFGDIDLCASELLRQSPKRAQELWGLP-QTISDITGLVISYLK 399
>M7UVH6_BOTFU (tr|M7UVH6) Putative methylenetetrahydrofolate reductase protein
OS=Botryotinia fuckeliana BcDW1 GN=BcDW1_301 PE=4 SV=1
Length = 622
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 178/388 (45%), Positives = 243/388 (62%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFEFFPPKT GV NL++RMDRM PSF DITWGAGG A +T E+ Q+ +E
Sbjct: 18 FSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAQLTCEMVGVAQSQYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M EK+D AL+ G N+LALRGDPP ++K+ TEGGF A+DLV H
Sbjct: 78 TCMHLTCTDMGKEKVDEALRNAYKAGCTNILALRGDPPREKEKWEATEGGFQYAKDLVHH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE G + L +LK KVDAGA IVTQ+FYD
Sbjct: 138 IRQTYGNHFDIGVAGYPE---------GCDDQDDEDLLLDHLKEKVDAGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+ ++ G+ P++PGIMPIN Y F+R KIP + AALE +K+++
Sbjct: 189 VDNFIDWLGKVKARGVNVPVIPGIMPINTYASFLRRCNHMGCKIPPKWSAALEEVKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L EMCR+I+ G+ LH YT+N+ ++ +L L L ++ + +LPWR
Sbjct: 249 AVRNIGKDLVAEMCRRIIEAGVHHLHFYTMNLAQATRMVLEELSLTPSNQRPLKHALPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWKNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGIGLKGS 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ + + W P +SI+DI + + YL+
Sbjct: 369 NEQNI-KLWGQP-KSIKDIAELFVSYLE 394
>G2YUL6_BOTF4 (tr|G2YUL6) Methylenetetrahydrofolate reductase OS=Botryotinia
fuckeliana (strain T4) GN=BofuT4_P157100.1 PE=3 SV=1
Length = 622
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 178/388 (45%), Positives = 243/388 (62%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFEFFPPKT GV NL++RMDRM PSF DITWGAGG A +T E+ Q+ +E
Sbjct: 18 FSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAQLTCEMVGVAQSQYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M EK+D AL+ G N+LALRGDPP ++K+ TEGGF A+DLV H
Sbjct: 78 TCMHLTCTDMGKEKVDEALRNAYKAGCTNILALRGDPPREKEKWEATEGGFQYAKDLVHH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE G + L +LK KVDAGA IVTQ+FYD
Sbjct: 138 IRQTYGNHFDIGVAGYPE---------GCDDQDDEDLLLDHLKEKVDAGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+ ++ G+ P++PGIMPIN Y F+R KIP + AALE +K+++
Sbjct: 189 VDNFIDWLGKVKARGVNVPVIPGIMPINTYASFLRRCNHMGCKIPPKWSAALEEVKNDDA 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L EMCR+I+ G+ LH YT+N+ ++ +L L L ++ + +LPWR
Sbjct: 249 AVRNIGKDLVAEMCRRIIEAGVHHLHFYTMNLAQATRMVLEELSLTPSNQRPLKHALPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWKNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGIGLKGS 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ + + W P +SI+DI + + YL+
Sbjct: 369 NEQNI-KLWGQP-KSIKDIAELFVSYLE 394
>K1VJG4_TRIAC (tr|K1VJG4) Methylenetetrahydrofolate reductase OS=Trichosporon
asahii var. asahii (strain CBS 8904) GN=A1Q2_04779 PE=3
SV=1
Length = 594
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 175/373 (46%), Positives = 229/373 (61%), Gaps = 10/373 (2%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K+ R +SFE+FPP+T G+ NL++R++RM P F DITWGAGG
Sbjct: 1 MKITDKLAKAEREG--RPFWSFEYFPPRTAQGLQNLYDRIERMRNLGPEFIDITWGAGGK 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
AD+T + Q + +ET +HLTCT MP EK++ AL K G QN+LALRGDPP G
Sbjct: 59 NADLTSSLVQVCQETIGIETCMHLTCTEMPKEKVEWALAQAKQFGCQNILALRGDPPAGS 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ T GGF A DLVK+I +Y F + VAG+P+ HP+ T E + E+ +
Sbjct: 119 STWKPTPGGFVHAVDLVKYIHKEYPGDFCVAVAGFPDGHPET-----PPTPEGHHQEMLW 173
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I TQ+FYD DI +V + GIT PIVPGIMPI N++ F
Sbjct: 174 LKEKVDAGADFIFTQMFYDVDILFNWVKEVRSYGITVPIVPGIMPIQNWQKFQTWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH---GIKTLHLYTLNMEKSALA 297
K+P AL P+K ++E V+ G L EMCR ILA+ GIK LH+YTLN+EK A
Sbjct: 234 IKVPEHWYEALNPVKGDDEQVRAVGTKLVGEMCRAILANEECGIKGLHVYTLNLEKGARM 293
Query: 298 ILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWG 357
+L LG+ + LPWR R +E +RPIFWANR +SY+SRT WD++P+GRWG
Sbjct: 294 LLEELGMNPNREQVAPLPWRPSLAANRRQESIRPIFWANRVESYLSRTSDWDEFPNGRWG 353
Query: 358 DSGNPSYGALTDY 370
DS +P+YG L Y
Sbjct: 354 DSRSPAYGDLDGY 366
>J6F727_TRIAS (tr|J6F727) Methylenetetrahydrofolate reductase OS=Trichosporon
asahii var. asahii (strain ATCC 90039 / CBS 2479 / JCM
2466 / KCTC 7840 / NCYC 2677 / UAMH 7654) GN=A1Q1_00789
PE=3 SV=1
Length = 594
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 175/373 (46%), Positives = 229/373 (61%), Gaps = 10/373 (2%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K+ R +SFE+FPP+T G+ NL++R++RM P F DITWGAGG
Sbjct: 1 MKITDKLAKAEREG--RPFWSFEYFPPRTAQGLQNLYDRIERMRNLGPEFIDITWGAGGK 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
AD+T + Q + +ET +HLTCT MP EK++ AL K G QN+LALRGDPP G
Sbjct: 59 NADLTSSLVQVCQETIGIETCMHLTCTEMPKEKVEWALAQAKQFGCQNILALRGDPPAGS 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+ T GGF A DLVK+I +Y F + VAG+P+ HP+ T E + E+ +
Sbjct: 119 STWKPTPGGFVHAVDLVKYIHKEYPGDFCVAVAGFPDGHPET-----PPTPEGHHQEMLW 173
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK KVDAGAD I TQ+FYD DI +V + GIT PIVPGIMPI N++ F
Sbjct: 174 LKEKVDAGADFIFTQMFYDVDILFNWVKEVRSYGITVPIVPGIMPIQNWQKFQTWVQREN 233
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH---GIKTLHLYTLNMEKSALA 297
K+P AL P+K ++E V+ G L EMCR ILA+ GIK LH+YTLN+EK A
Sbjct: 234 IKVPEHWYEALNPVKGDDEQVRAVGTKLVGEMCRAILANEECGIKGLHVYTLNLEKGARM 293
Query: 298 ILTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWG 357
+L LG+ + LPWR R +E +RPIFWANR +SY+SRT WD++P+GRWG
Sbjct: 294 LLEELGMNPNREQVAPLPWRPSLAANRRQESIRPIFWANRVESYLSRTSDWDEFPNGRWG 353
Query: 358 DSGNPSYGALTDY 370
DS +P+YG L Y
Sbjct: 354 DSRSPAYGDLDGY 366
>B2B2M5_PODAN (tr|B2B2M5) Methylenetetrahydrofolate reductase OS=Podospora
anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC
10383) PE=3 SV=1
Length = 610
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 176/383 (45%), Positives = 241/383 (62%), Gaps = 14/383 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFE+FPPKT GV NL++RM+RM P F DITWGAGG A++T E+ + Q + +E
Sbjct: 18 FSFEYFPPKTTQGVQNLYDRMERMNNFGPKFIDITWGAGGRIAELTCEMVVQAQTYLGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M EK+++AL+ G N+LALRGDPP ++K+ EGGF ARDLV+H
Sbjct: 78 TCMHLTCTDMGEEKVNDALRKAYKAGCTNILALRGDPPREKEKWEAAEGGFRYARDLVQH 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR Y ++F I VAGYPE D D + L +LK KVDAGA IVTQ+FYD
Sbjct: 138 IRKSYHEHFDIGVAGYPEGCDDNKDEDLL---------LDHLKEKVDAGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+++V GI PI+PGIMPI Y F+R KIP E M LEP+K+++
Sbjct: 189 ADNFVRWVGKVRARGINVPIIPGIMPIATYASFLRRANHMNCKIPDEWMQRLEPVKNDDV 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPWR 317
AV+ G L E+CRKILA GI LH YT+N+ ++ +L L + + + ++LPW+
Sbjct: 249 AVRDIGKTLVAELCRKILAAGIHHLHFYTMNLAQATRMVLEELDWMPSPDRPVKQALPWK 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
R + R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y
Sbjct: 309 RSLGLGRQVEDVRPIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGT 368
Query: 378 RDKKLTEEWAVP--LRSIEDIYV 398
++ ++W P +R I +++V
Sbjct: 369 NEQN-RQKWGEPTCIRDIANLFV 390
>H2MXI6_ORYLA (tr|H2MXI6) Methylenetetrahydrofolate reductase OS=Oryzias latipes
GN=LOC101173920 PE=3 SV=1
Length = 657
Score = 348 bits (892), Expect = 3e-93, Method: Compositional matrix adjust.
Identities = 180/392 (45%), Positives = 247/392 (63%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G GS + + + IA+ N
Sbjct: 62 FSLEFFPPRTASGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 121
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N EKI L K GL+N++ALRGDP G D + + E GF A D
Sbjct: 122 CGLESVLHLTCCNQTKEKITGYLAKAKHLGLKNIMALRGDP-IGTD-WEEEEEGFNFAVD 179
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ DYF I VAGYP HP+A ++Y+++L +LK KVDAGAD ++TQ
Sbjct: 180 LVKHIRSEFDDYFDICVAGYPTGHPEA---------DSYEDDLRHLKDKVDAGADFVITQ 230
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ D FLKF++DC IGITCPI+PGI PI Y+ ++ K ++P +I +EPIK
Sbjct: 231 LFFRADTFLKFLDDCRAIGITCPILPGIFPIQGYQSLRQLVKLSKLEVPEDITKVIEPIK 290
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGIHL EMC +L G + LH YTLN E + + +L LGL E R L
Sbjct: 291 DNDAAIRNYGIHLAVEMCSVLLESGNVPGLHFYTLNREVATMEVLRQLGLWLEDP-RRPL 349
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW N R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 350 PWAVSANPKRKVEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELNDYYLFY 409
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L++ + ++ V Y+
Sbjct: 410 LKSKSSKEALLQMWGEELKNEQSVFEVFTNYI 441
>M4AE75_XIPMA (tr|M4AE75) Methylenetetrahydrofolate reductase OS=Xiphophorus
maculatus GN=MTHFR PE=3 SV=1
Length = 661
Score = 347 bits (891), Expect = 4e-93, Method: Compositional matrix adjust.
Identities = 178/392 (45%), Positives = 244/392 (62%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM + P + DITW G GS + + + IA+ N
Sbjct: 64 FSLEFFPPRTASGAVNLISRFDRMGSGGPLYIDITWHPAGDPGSDKETSSMMIASTAVNY 123
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N EKI L K GL+N++ALRGDP D + EGGF A D
Sbjct: 124 CGLESILHLTCCNQTKEKITGYLAKAKHLGLKNIMALRGDPVG--DDWEDEEGGFNFAVD 181
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ +YF I VAGYP HP+A E+Y+ +L +LK KVDAGAD ++TQ
Sbjct: 182 LVKHIRSEFDEYFDICVAGYPTGHPEA---------ESYEQDLRHLKEKVDAGADFVITQ 232
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ D FLKF++DC GITCPI+PGI PI Y+ ++ K ++P EI +EPIK
Sbjct: 233 LFFRADTFLKFLDDCRAAGITCPILPGIFPIQGYQSLRQLVKMSKLEVPEEITKIIEPIK 292
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGIH +MCR +L G + LH YTLN E + + +L LGL E R L
Sbjct: 293 DNDAAIRNYGIHQAVDMCRVLLDSGKVPGLHFYTLNREVATMEVLRQLGLWVEDP-RRPL 351
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW N R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 352 PWAVSANPKRKVEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELNDYYLFY 411
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L++ + ++ V Y+
Sbjct: 412 LKSKSSKEALLQMWGEELKNEQSVFEVFTCYI 443
>G0WG35_NAUDC (tr|G0WG35) Methylenetetrahydrofolate reductase OS=Naumovozyma
dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 /
NBRC 0211 / NRRL Y-12639) GN=NDAI0I01770 PE=3 SV=1
Length = 598
Score = 347 bits (890), Expect = 4e-93, Method: Compositional matrix adjust.
Identities = 179/399 (44%), Positives = 251/399 (62%), Gaps = 20/399 (5%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MKV EK+ + FSFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKVTEKLEASHKSS-SKTTFSFEYFVPKTSQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ + Q+++ +ET +HLTCTNMP+E+ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSQLSTDLISTAQSVLGLETCMHLTCTNMPIEEIDSALKKAYDSGCQNILALRGDPPI 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+K+ EGGF A+DL+K+IR KYGDYF I VAGYPE HP+ + +
Sbjct: 120 NSNKWEACEGGFNYAKDLIKYIRLKYGDYFDIGVAGYPEGHPEE---------KDIELNF 170
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG + I+TQ+FYD D F+ + + GI PI+PGIMPI Y F+R +
Sbjct: 171 KYLKEKIDAGGNFIITQMFYDVDNFIDWCDKVRAYGIDVPIIPGIMPITTYGAFLRRAQW 230
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP + + L+PIKD++E V+ G L MC+K++ G +K LH+YT+N+EK+ L
Sbjct: 231 GEINIPQDFLDKLDPIKDDDELVREMGTELIVGMCQKLIDSGHVKHLHIYTMNLEKAPLM 290
Query: 298 ILTSLGLI-EESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL LGL+ E + + + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 291 ILDKLGLLPTEGEYNGAQEAMLPWRKSLNPKRKNEEVRPIFWQRRPYSYVARTSQWAVDE 350
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVP 389
+P+GR+GDS +P++G L + R KK E W+ P
Sbjct: 351 FPNGRFGDSSSPAFGDLDLFGAPLIRQSSKKSLELWSTP 389
>A6RBU9_AJECN (tr|A6RBU9) Methylenetetrahydrofolate reductase OS=Ajellomyces
capsulata (strain NAm1 / WU24) GN=HCAG_07107 PE=3 SV=1
Length = 619
Score = 347 bits (890), Expect = 5e-93, Method: Compositional matrix adjust.
Identities = 178/386 (46%), Positives = 246/386 (63%), Gaps = 28/386 (7%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM + PSF DITWGAGG +++T E+ N Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGYGPSFIDITWGAGGRLSELTCEMVNVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D A+Q+ G N+LALRGDPP ++K+ EGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPREKVDAAIQSAFKAGCTNILALRGDPPREKEKWEAIEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I VAGYPE D D + + +LK KVDAG I+TQ+
Sbjct: 135 VKYIRDKYGNHFDIGVAGYPEGCDDQDDPDLL---------MQHLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +VN C GIT PI+PGIMPI+ IP + + ALEP+K+
Sbjct: 186 FYDVDNFLAWVNKCRDNGITVPIIPGIMPIHT--------------IPPDWLEALEPVKN 231
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSL 314
++ AV+ G L MCRK+LA GI LH YT+N++++ +L L LI K + + L
Sbjct: 232 DDVAVRNLGKSLVANMCRKMLAAGIHHLHFYTMNLQQATKMVLGELELIPSHKTPLQKPL 291
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD+YP+GRW DS +P++G L Y +
Sbjct: 292 PWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSRSPAFGELDTYG-IG 350
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P L+ + +I+V
Sbjct: 351 LKGTNEQNIKLWGEPKSLKELSEIFV 376
>J4TZ22_SACK1 (tr|J4TZ22) Methylenetetrahydrofolate reductase OS=Saccharomyces
kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS
8840 / NBRC 1802 / NCYC 2889) GN=YGL125W PE=3 SV=1
Length = 600
Score = 347 bits (889), Expect = 7e-93, Method: Compositional matrix adjust.
Identities = 181/414 (43%), Positives = 258/414 (62%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ Q+++ +ET +HLTCTNMP+ ID+AL++ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALESAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
D + EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DTDSWTPVEGGFLYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDA-------KLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + ++ G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFISWCSEVRAAGMAVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP ++ LEPIKD++E V+ G +L +MC+K+L G I LH+YT+N+EK+ L
Sbjct: 233 GQISIPQAFLSQLEPIKDDDELVRDIGTNLIVQMCQKLLNSGYISHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLI-EESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R + E W+ P SI DI + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANRCLELWSTP-ASINDIAFLVINYL 405
>A7EWQ5_SCLS1 (tr|A7EWQ5) Methylenetetrahydrofolate reductase OS=Sclerotinia
sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
GN=SS1G_09764 PE=3 SV=1
Length = 590
Score = 347 bits (889), Expect = 7e-93, Method: Compositional matrix adjust.
Identities = 177/388 (45%), Positives = 244/388 (62%), Gaps = 13/388 (3%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCVE 79
FSFEFFPPKT GV NL++RMDRM PSF DITWGAGG A +T E+ Q+ +E
Sbjct: 18 FSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAQLTCEMVGVAQSQYGLE 77
Query: 80 TMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVKH 139
T +HLTCT+M EK+D AL+ G N+LALRGDPP ++K+ TEGGF A+DLV +
Sbjct: 78 TCMHLTCTDMGKEKVDEALRNAYKAGCTNILALRGDPPREKEKWEATEGGFQYAKDLVHY 137
Query: 140 IRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFYD 199
IR YG++F I VAGYPE G + L +LK KVDAGA IVTQ+FYD
Sbjct: 138 IRQTYGNHFDIGVAGYPE---------GCDDQDDEDLLLDHLKEKVDAGATFIVTQMFYD 188
Query: 200 TDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEE 259
D F+ ++ G+T P++PGIMPIN Y F+R KIP + A+LE +K+++
Sbjct: 189 VDNFIDWLGKVKARGVTIPVIPGIMPINTYASFLRRCNHMGCKIPPKWSASLEAVKNDDS 248
Query: 260 AVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESK--ISRSLPWR 317
AV+ G L EMCR+I+ G+ LH YT+N+ ++ +L L L ++ + +LPWR
Sbjct: 249 AVRNIGKDLVAEMCRRIIQAGVHHLHFYTMNLAQATRMVLEELNLTPSTQRPLKHALPWR 308
Query: 318 RPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPRA 377
+ + R EDVRPIFW NR KSY++RT WD++P+GRWGDS +P++G L Y +
Sbjct: 309 QSLGLGRREEDVRPIFWKNRNKSYVARTQDWDEFPNGRWGDSRSPAFGELDAYGIGLKGS 368
Query: 378 RDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ + + W P +SI+DI + + YL+
Sbjct: 369 NEQNI-KLWGQP-KSIKDIAELFVSYLE 394
>G7DSI2_MIXOS (tr|G7DSI2) Methylenetetrahydrofolate reductase OS=Mixia osmundae
(strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970)
GN=Mo00186 PE=3 SV=1
Length = 608
Score = 346 bits (888), Expect = 8e-93, Method: Compositional matrix adjust.
Identities = 175/408 (42%), Positives = 245/408 (60%), Gaps = 18/408 (4%)
Query: 2 KVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGST 61
K+ +K+R + R +SFE+FPP+TE G+ NL++R+ RM A P F DITWGAGG+T
Sbjct: 5 KISDKIRAAH--NEGRNWWSFEYFPPRTEQGLINLYDRIGRMAALGPIFIDITWGAGGTT 62
Query: 62 ADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQD 121
+D T + +ET +HLTCTNM V ++ AL+ +G +N+LALRGDPP GQ+
Sbjct: 63 SDATTQFVKTAHEQFGLETNMHLTCTNMEVGMVERALKEAYDSGCRNILALRGDPPRGQE 122
Query: 122 KFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYL 181
++ TEGGF A DL+K+IR Y DYF I VAG+PE HP A + E+ +L
Sbjct: 123 EWKATEGGFNHAIDLIKYIRKNYDDYFDIAVAGFPEGHPQA---------SSRAEEIEHL 173
Query: 182 KSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKT 241
K+K+DAGA +I+TQ+FYD D F+ + +D + GI IVPGIMPI ++ F + F KT
Sbjct: 174 KAKIDAGASIIITQMFYDIDTFINWAHDVRKAGINALIVPGIMPIQGWQSFQKCISFSKT 233
Query: 242 KIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKIL--AHGIKTLHLYTLNMEKSALAIL 299
+P LEPIKD++ AV+ G L +MCR+IL I LH YT+N+EK+ +L
Sbjct: 234 IVPQHFFDVLEPIKDDDAAVREAGTKLVADMCRQILDSPFDIHGLHFYTMNLEKATSMLL 293
Query: 300 TSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDS 359
L +I+ LPW+ R E +RPIFWANR SY +RT WD++P+GRWGDS
Sbjct: 294 EELNFTASVEITNPLPWKPSLTTKRRSESIRPIFWANRAGSYRARTESWDEFPNGRWGDS 353
Query: 360 GNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
+P++G Y R + L+ W P + DI L+ ++C
Sbjct: 354 RSPAFGKFEGYGITLKPERGECLS-MWGSPT-TFADI---ASLFARFC 396
>B6QPH8_PENMQ (tr|B6QPH8) Methylenetetrahydrofolate reductase OS=Penicillium
marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
GN=PMAA_048540 PE=3 SV=1
Length = 607
Score = 346 bits (887), Expect = 1e-92, Method: Compositional matrix adjust.
Identities = 183/392 (46%), Positives = 251/392 (64%), Gaps = 14/392 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFE+FPPKT GV NL++RMDRM P+F D+TWGAGGS +++T E+ Q +
Sbjct: 15 RPGISFEYFPPKTAQGVQNLYDRMDRMHDLGPAFIDVTWGAGGSRSELTCEMVRIAQTVF 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP E++D AL+ + G N+LALRGDPP Q+K+ EGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPRERVDAALEAAYNAGCTNILALRGDPPREQEKWEAAEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ IVTQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDNPDVDQL---------IDHLKEKVDAGSTFIVTQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V C GI IVPGIMPI+ Y F+R + + K +IP + + LEP+K
Sbjct: 186 FYDVDNFLNWVEKCRAKGINAAIVPGIMPISTYDAFMRRSNWTKIRIPPDWLEKLEPVKA 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLI--EESKISRS 313
++ V+ G L EMCRK+LA G I LH YT+N+ ++ IL L L+ EE+ + +
Sbjct: 246 DDAKVREVGTKLVAEMCRKLLASGHIHHLHFYTMNLAQATRLILEELRLLPSEEAPLQKP 305
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
LPWRR + R EDVRPIFW NR SYI+RT WD+YP+GRW D+ +P++G L Y +
Sbjct: 306 LPWRRSLGLRRRSEDVRPIFWRNRNASYIARTADWDEYPNGRWTDARSPAFGELNAYG-V 364
Query: 374 RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
R + +++ + W P +SI+D+ + L YL
Sbjct: 365 RLKGTNEQNIKLWGAP-KSIKDLSDIFLRYLN 395
>H0GUP5_9SACH (tr|H0GUP5) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae x Saccharomyces kudriavzevii VIN7
GN=VIN7_7061 PE=3 SV=1
Length = 540
Score = 346 bits (887), Expect = 1e-92, Method: Compositional matrix adjust.
Identities = 181/414 (43%), Positives = 257/414 (62%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ Q+++ +ET +HLTCTNMP+ ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
D + EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DADSWTPVEGGFLYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDA-------KLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + ++ G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFISWCSEVRAAGMAVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP ++ LEPIKD++E V+ G +L +MC+K+L G I LH+YT+N+EK+ L
Sbjct: 233 GQISIPQAFLSQLEPIKDDDELVRDIGTNLIVQMCQKLLNSGYISHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLI-EESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R + E W+ P SI DI + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANRCLELWSTP-ASINDIAFLVINYL 405
>C3XPI2_BRAFL (tr|C3XPI2) Methylenetetrahydrofolate reductase OS=Branchiostoma
floridae GN=BRAFLDRAFT_262151 PE=3 SV=1
Length = 686
Score = 345 bits (886), Expect = 1e-92, Method: Compositional matrix adjust.
Identities = 174/393 (44%), Positives = 239/393 (60%), Gaps = 19/393 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADV-----TLEIANKMQN 74
FS EFFPP+T G NL R +RMV P F DITW G + ++ IA N
Sbjct: 47 FSLEFFPPRTPQGAANLISRFERMVQGGPMFMDITWHPAGDPGNSDKETSSMSIACAALN 106
Query: 75 IVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACAR 134
V ETM+H++C N + I L K G++N+LALRGDP G D++ E GF A
Sbjct: 107 YVGHETMLHMSCCNSTKDDIRRHLDKAKELGIRNILALRGDPIVG-DEWKYVEDGFNYAT 165
Query: 135 DLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVT 194
D+VK IRA++GDYF + VAGYP HPD + Y+ +L +LK KVDAGAD I+T
Sbjct: 166 DMVKFIRAEFGDYFTVCVAGYPHGHPD---------SPTYEEDLQHLKEKVDAGADFIIT 216
Query: 195 QLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPI 254
QLF+ + ++KFV DC +IGI PI+PG+MPI Y + K +IP EI A+EPI
Sbjct: 217 QLFFKAERYVKFVEDCRRIGINVPIIPGVMPIQGYHSLRNLVKLSKLEIPDEIREAIEPI 276
Query: 255 KDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRS 313
+DN+EA++ YG+H M R++ G + LH YTLN E + + IL +GL E I R
Sbjct: 277 RDNDEAIRNYGVHQAVTMIRELFDSGLVNGLHFYTLNREVATIQILKQIGLWTED-IQRP 335
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
PW+R N R E+VRPIFWA+RPKSY+ RT WD++P+GRWG S +P++G L DY
Sbjct: 336 WPWKRTANYNRCEEEVRPIFWASRPKSYVYRTQEWDEFPNGRWGSSESPAFGELNDYYLF 395
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++P A+ ++L + W L ++D+ V Y+
Sbjct: 396 YLKPNAKKEELLDMWGHELTCLQDVCDVFTNYI 428
>L9L5F0_TUPCH (tr|L9L5F0) Methylenetetrahydrofolate reductase OS=Tupaia chinensis
GN=TREES_T100008875 PE=3 SV=1
Length = 643
Score = 345 bits (886), Expect = 1e-92, Method: Compositional matrix adjust.
Identities = 178/392 (45%), Positives = 242/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G GS + + + IA+ N
Sbjct: 47 FSLEFFPPRTAQGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 106
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 107 CGLETILHMTCCQQSQEEITGHLHKAKQLGLKNILALRGDPIG--DQWEEEEGGFNYAVD 164
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++GDYF I VAGYP+ HP+A E+ + +L LK KV AGAD I+TQ
Sbjct: 165 LVKHIRNEFGDYFDICVAGYPKGHPEA---------ESLEADLKRLKEKVSAGADFIITQ 215
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +IGITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 216 LFFEADTFFRFVKACTEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 275
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 276 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 334
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 335 PWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 394
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 395 LKSKSPKEELLKMWGEELASEESVFEVFAHYL 426
>Q59GJ6_HUMAN (tr|Q59GJ6) Methylenetetrahydrofolate reductase (Fragment) OS=Homo
sapiens PE=2 SV=1
Length = 672
Score = 345 bits (886), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 173/393 (44%), Positives = 243/393 (61%), Gaps = 19/393 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P + D+TW G ++ IA+ N
Sbjct: 90 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNY 149
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 150 CGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 207
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A +++ +L +LK KV AGAD I+TQ
Sbjct: 208 LVKHIRSEFGDYFDICVAGYPKGHPEA---------GSFEADLKHLKEKVSAGADFIITQ 258
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 259 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 318
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 319 DNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 377
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 378 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 437
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
++ ++ ++L + W L S ++ V +LYL
Sbjct: 438 LKSKSPKEELLKMWGEELTSEASVFEVFVLYLS 470
>G8F4Z9_MACFA (tr|G8F4Z9) Methylenetetrahydrofolate reductase OS=Macaca
fascicularis GN=EGM_20670 PE=3 SV=1
Length = 697
Score = 345 bits (886), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 243/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 101 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 160
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 161 CGLETILHMTCCCQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 218
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 219 LVKHIRSEFGDYFDLCVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 269
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 270 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 329
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C ++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 330 DNDAAIRNYGIELAVSLCHELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 388
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 389 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 448
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E ++ V +LYL
Sbjct: 449 LKSKSPRELLLKMWGEELTSEESVFEVFVLYL 480
>F7CI98_MACMU (tr|F7CI98) Methylenetetrahydrofolate reductase OS=Macaca mulatta
GN=MTHFR PE=2 SV=1
Length = 697
Score = 345 bits (886), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 243/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 101 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 160
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 161 CGLETILHMTCCCQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 218
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 219 LVKHIRSEFGDYFDLCVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 269
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 270 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 329
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C ++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 330 DNDAAIRNYGIELAVSLCHELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 388
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 389 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 448
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E ++ V +LYL
Sbjct: 449 LKSKSPRELLLKMWGEELTSEESVFEVFVLYL 480
>H9FUQ0_MACMU (tr|H9FUQ0) Methylenetetrahydrofolate reductase OS=Macaca mulatta
GN=MTHFR PE=2 SV=1
Length = 656
Score = 345 bits (886), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 243/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 60 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 119
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 120 CGLETILHMTCCCQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 177
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 178 LVKHIRSEFGDYFDLCVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 228
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 229 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 288
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C ++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 289 DNDAAIRNYGIELAVSLCHELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 347
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 348 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 407
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E ++ V +LYL
Sbjct: 408 LKSKSPRELLLKMWGEELTSEESVFEVFVLYL 439
>K5X1L7_AGABU (tr|K5X1L7) Methylenetetrahydrofolate reductase OS=Agaricus
bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627
/ FGSC 10392) GN=AGABI1DRAFT_111963 PE=3 SV=1
Length = 600
Score = 345 bits (885), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 183/409 (44%), Positives = 263/409 (64%), Gaps = 17/409 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K++ + ++ +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MKISQKIQQQSKEN--KLWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T ++ Q+++ +ET +HLTCTNMP+EK+D AL+ K++G +NVLALRGDPP G+
Sbjct: 59 TSELTSQMVKTCQSLIGIETCMHLTCTNMPIEKVDIALREAKASGCRNVLALRGDPPAGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+++ EGGF DLV+HIR YGDYF I +AG+P+ + E + E+ +
Sbjct: 119 EEWEAIEGGFVHGIDLVRHIRKLYGDYFDIAIAGFPQQM--------LLPPEELEQEMMW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG I TQ+FYD +IF+K+V+ + GIT PI+PGI PI + GF+R T K
Sbjct: 171 LKEKIDAGCSFIFTQMFYDVEIFIKWVHCVREHGITIPIIPGIAPIQTWNGFMRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T IP M LEPIK+N+E V+ GI L +MCR+ILA GI+ LH YT+N+EK +
Sbjct: 231 TIIPQSFMDVLEPIKNNDEQVRKLGIKLVADMCRRILAEPLGIQGLHFYTMNLEKGTKML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R E +RPIFWANR +SY+SRT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRVETIKPLPWRQSLTPSRRAETIRPIFWANRAQSYVSRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
S +P+YG L Y +D L + W P ++ D V L+ ++C
Sbjct: 351 SRSPAYGELDGYGVSLKHTKDDAL-KLWGEP-KTFAD---VTSLFTRFC 394
>F7GJ76_MACMU (tr|F7GJ76) Methylenetetrahydrofolate reductase OS=Macaca mulatta
GN=MTHFR PE=2 SV=1
Length = 679
Score = 345 bits (884), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 176/392 (44%), Positives = 243/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 83 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 142
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +E+I L K GL+N++ALRGDP D++ + EGGF A D
Sbjct: 143 CGLETILHMTCCCQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQWEEEEGGFNYAVD 200
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HP+A GS ++ +L +LK KV AGAD I+TQ
Sbjct: 201 LVKHIRSEFGDYFDLCVAGYPKGHPEA-GS--------FEADLKHLKEKVSAGADFIITQ 251
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +GITCPIVPGI PI Y ++ K ++P EI +EPIK
Sbjct: 252 LFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 311
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +C ++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 312 DNDAAIRNYGIELAVSLCHELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPL 370
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 371 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 430
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ + L + W L S E ++ V +LYL
Sbjct: 431 LKSKSPRELLLKMWGEELTSEESVFEVFVLYL 462
>K9I4E4_AGABB (tr|K9I4E4) Methylenetetrahydrofolate reductase OS=Agaricus
bisporus var. bisporus (strain H97 / ATCC MYA-4626 /
FGSC 10389) GN=AGABI2DRAFT_193205 PE=3 SV=1
Length = 600
Score = 345 bits (884), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 183/409 (44%), Positives = 263/409 (64%), Gaps = 17/409 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGS 60
MK+ +K++ + ++ +SFE+FPP+T G+ NL +R++RM A P F DITW AGG
Sbjct: 1 MKISQKIQQQSKEN--KLWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFIDITWNAGGR 58
Query: 61 TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQ 120
T+++T ++ Q+++ +ET +HLTCTNMP+EK+D AL+ K++G +NVLALRGDPP G+
Sbjct: 59 TSELTSQMVKTCQSLIGIETCMHLTCTNMPIEKVDIALREAKASGCRNVLALRGDPPAGK 118
Query: 121 DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTY 180
+++ EGGF DLV+HIR YGDYF I +AG+P+ + E + E+ +
Sbjct: 119 EEWEAIEGGFVHGIDLVRHIRKLYGDYFDIAIAGFPQQM--------LLPPEELEQEMIW 170
Query: 181 LKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCK 240
LK K+DAG I TQ+FYD +IF+K+V+ + GIT PI+PGI PI + GF+R T K
Sbjct: 171 LKEKIDAGCSFIFTQMFYDVEIFIKWVHCVREHGITIPIIPGIAPIQTWNGFMRATSLAK 230
Query: 241 TKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAI 298
T IP M LEPIK+N+E V+ GI L +MCR+ILA GI+ LH YT+N+EK +
Sbjct: 231 TIIPQSFMDVLEPIKNNDEQVRKLGIKLVADMCRRILAEPLGIQGLHFYTMNLEKGTKML 290
Query: 299 LTSLGLIEESKISRSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGD 358
L L L+ + + LPWR+ R E +RPIFWANR +SY+SRT WD+YP+GR+GD
Sbjct: 291 LEELNLVPRVETIKPLPWRQSLTPSRRAETIRPIFWANRAQSYVSRTENWDEYPNGRFGD 350
Query: 359 SGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQYC 407
S +P+YG L Y +D L + W P ++ D V L+ ++C
Sbjct: 351 SRSPAYGELDGYGVSLKHTKDDAL-KLWGEP-KTFAD---VTSLFTRFC 394
>I3MA17_SPETR (tr|I3MA17) Methylenetetrahydrofolate reductase (Fragment)
OS=Spermophilus tridecemlineatus GN=MTHFR PE=3 SV=1
Length = 686
Score = 344 bits (883), Expect = 3e-92, Method: Compositional matrix adjust.
Identities = 175/392 (44%), Positives = 241/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R D+M A P F D+TW G ++ IA+ N
Sbjct: 92 FSLEFFPPRTAEGAANLIARFDQMAAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 151
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N+LALRGDP D++ EGGF+ A D
Sbjct: 152 CGLETILHMTCCRQCPEEITGHLHKAKQLGLKNILALRGDPI--GDQWETEEGGFSYAAD 209
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HPDA ++++++L +LK KV AGAD I+TQ
Sbjct: 210 LVKHIRSEFGDYFDICVAGYPKGHPDA---------QSFEDDLKHLKEKVSAGADFIITQ 260
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ + F FV C GITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 261 LFFEANTFFHFVKACTATGITCPILPGIFPIQGYSSLRQLMKLSKLEVPQEIKDVIEPIK 320
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++LA G + LH YTLN E + +L LGL E R L
Sbjct: 321 DNDAAIRNYGIELAVSLCRELLASGLVPGLHFYTLNREVATTEVLKRLGLWTEDP-RRPL 379
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 380 PWAISAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELRDYYLFY 439
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 440 LKSKSPREELLKMWGEELCSEESVFEVFAHYL 471
>B8M3Q9_TALSN (tr|B8M3Q9) Methylenetetrahydrofolate reductase OS=Talaromyces
stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 /
NRRL 1006) GN=TSTA_038580 PE=3 SV=1
Length = 607
Score = 344 bits (883), Expect = 3e-92, Method: Compositional matrix adjust.
Identities = 181/392 (46%), Positives = 253/392 (64%), Gaps = 14/392 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFE+FPPKT GV NL++RMDRM P+F D+TWGAGGS +++T E+ Q +
Sbjct: 15 RPGISFEYFPPKTAQGVQNLYDRMDRMHDLGPAFIDVTWGAGGSRSELTCEMVRIAQTVF 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP E++D AL++ + G N+LALRGDPP Q+K+ EGGF A+DL
Sbjct: 75 GLETCMHLTCTDMPRERVDAALESAYNAGCTNILALRGDPPREQEKWEAAEGGFRYAKDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VK+IR KYG++F I V GYPE D D + + +LK KVDAG+ IVTQ+
Sbjct: 135 VKYIREKYGNHFDIGVGGYPEGADDNPDVDQL---------IDHLKEKVDAGSSFIVTQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D FL +V+ C GI I+PGIMPI+ Y F+R + + K +IP + + LEP+K
Sbjct: 186 FYDVDNFLDWVSKCRAKGIKAAIIPGIMPISTYDAFMRRSNWTKIRIPPDWLDKLEPVKA 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLI--EESKISRS 313
++ V+ G L EMCRK+LA G I LH YT+N+ ++ IL L L+ EE+ + +
Sbjct: 246 DDAKVREIGTKLVAEMCRKLLASGQIHHLHFYTMNLAQATRLILEELRLLPSEEAPLHKP 305
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFM 373
LPWRR + R EDVRPIFW NR SYI+RT WD+YP+GRW D+ +P++G L Y +
Sbjct: 306 LPWRRSLGLRRRSEDVRPIFWRNRNASYIARTADWDEYPNGRWTDARSPAFGELNAYG-V 364
Query: 374 RPRARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
R + +++ + W P +SI+D+ + + YL
Sbjct: 365 RLKGTNEQNIKLWGAP-KSIKDLSDIFVRYLN 395
>F6RK00_CIOIN (tr|F6RK00) Methylenetetrahydrofolate reductase OS=Ciona
intestinalis GN=LOC100180174 PE=3 SV=2
Length = 650
Score = 344 bits (882), Expect = 4e-92, Method: Compositional matrix adjust.
Identities = 176/391 (45%), Positives = 235/391 (60%), Gaps = 21/391 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+TE G NL R DRM A P F DITW G + +IA + N
Sbjct: 33 FSLEFFPPRTEQGAANLIGRFDRMRAGGPLFVDITWHPAGDPGSDKITSSTKIAGTVLNY 92
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQD---KFVQTEGGFAC 132
++TM+H+TC E I L+ K+ G++N+LALRG D + EGGF
Sbjct: 93 CGLDTMLHMTCVKQTKETIKKNLEKTKNLGIRNILALRGGISPNADADESWGYQEGGFNY 152
Query: 133 ARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLI 192
DLV+ I+ +YGD F I VAGYP HPD+ +YQ++L +LK K+DAG I
Sbjct: 153 GVDLVRFIKQEYGDAFSICVAGYPNGHPDST---------SYQDDLLHLKEKIDAGGQFI 203
Query: 193 VTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALE 252
+TQLF+ + FL FV DC +IGI CPI+PGI PI + +++T K IP EI +E
Sbjct: 204 ITQLFFTAEEFLTFVKDCREIGIDCPIIPGIFPIQTNRSLVQLTKLSKLSIPEEIQKVIE 263
Query: 253 PIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKIS 311
PIKDN+ A++ YGI L T+MCR +L G + LH+YTLN+E + + IL +LGL + ++
Sbjct: 264 PIKDNDAAIRKYGIDLATDMCRTLLNSGKVHGLHMYTLNLETATIQILKNLGLWCQD-VA 322
Query: 312 RSLPWRRPTN-VFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY 370
+ LPW+ N R E VRPIFW +RPKSYI RT GWD++P+GRWGDS +P++G L DY
Sbjct: 323 KPLPWKTSANPERRENETVRPIFWCDRPKSYIHRTQGWDEFPNGRWGDSASPAFGELKDY 382
Query: 371 Q--FMRPRARDKKLTEEWAVPLRSIEDIYVV 399
F+R R KL W L S D++ V
Sbjct: 383 HLFFLRSRTAKDKLRSLWGKELTSEADVWKV 413
>E4UPV6_ARTGP (tr|E4UPV6) Methylenetetrahydrofolate reductase OS=Arthroderma
gypseum (strain ATCC MYA-4604 / CBS 118893)
GN=MGYG_02935 PE=3 SV=1
Length = 614
Score = 344 bits (882), Expect = 4e-92, Method: Compositional matrix adjust.
Identities = 186/386 (48%), Positives = 251/386 (65%), Gaps = 14/386 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R SFEFFPPKT GV NL++RMDRM PSF DITWGAGG A++T E+ + Q++
Sbjct: 15 RPGISFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGRLAELTCEMVHVAQSVY 74
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCT+MP EK+D ALQ+ G N+LALRGDPP ++ + QTEGGF ARDL
Sbjct: 75 GLETCMHLTCTDMPREKVDEALQSAFKAGCTNILALRGDPPREKEAWEQTEGGFRYARDL 134
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
V++IR KYG++F I VAGYPE G E + + YLK KVDAG I+TQ+
Sbjct: 135 VQYIREKYGNHFDIGVAGYPE---------GCEDEEDPELLMKYLKEKVDAGGTFIITQM 185
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD D F+ +V C Q GI PI+PGIMPI+ Y FIR T + K +P M ALEP+K+
Sbjct: 186 FYDADNFIAWVRKCRQAGIKIPIIPGIMPISTYAAFIRRTKWVKCAVPKGWMEALEPVKN 245
Query: 257 NEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGL--IEESKISRSL 314
++ AVK G L EMCRK+L +GI LH YT+N+ +S +L L L E+ + + L
Sbjct: 246 DDAAVKHIGKALVAEMCRKLLDNGINHLHFYTMNLAQSTSMVLEELNLKPSSETPLQKPL 305
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMR 374
PWR+ + R EDVRPIFW +R +SY++RT WD++P+GRW DS +P++G L Y +
Sbjct: 306 PWRKSLGLGRREEDVRPIFWRHRHQSYVARTQSWDEFPNGRWTDSRSPAFGELDVYG-IG 364
Query: 375 PRARDKKLTEEWAVP--LRSIEDIYV 398
+ +++ + W P +R + DI+V
Sbjct: 365 LKGTNEQNIKLWGQPKSVRDLSDIFV 390
>L5KGS1_PTEAL (tr|L5KGS1) Methylenetetrahydrofolate reductase OS=Pteropus alecto
GN=PAL_GLEAN10012989 PE=3 SV=1
Length = 695
Score = 344 bits (882), Expect = 5e-92, Method: Compositional matrix adjust.
Identities = 177/392 (45%), Positives = 241/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 99 FSLEFFPPRTAQGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMVIASTAVNY 158
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC + E+I L K GL+N+LALRGDP D++ + EGGF A D
Sbjct: 159 CGLETILHMTCCHQSREEITGHLHKAKRLGLKNILALRGDPI--GDQWEEEEGGFCHAAD 216
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP HPDA GS ++ +L YLK KV AGAD I+TQ
Sbjct: 217 LVKHIRSEFGDYFDICVAGYPTGHPDA-GS--------FEADLKYLKEKVSAGADFIITQ 267
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F FV C +IGITCPI+PGI PI Y ++ K ++P ++ +EPIK
Sbjct: 268 LFFEADTFFHFVKACSEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQMKDVIEPIK 327
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI +C+K+LA G + LH YTLN E + +L LG+ E R L
Sbjct: 328 DNDAAIRNYGIEQAVSLCQKLLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRLL 386
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 387 PWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 446
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V + YL
Sbjct: 447 LKSKSPREELLKMWGEELASEESVFEVFVRYL 478
>G0T0T7_RHOG2 (tr|G0T0T7) Methylenetetrahydrofolate reductase OS=Rhodotorula
glutinis (strain ATCC 204091 / IIP 30 / MTCC 1151)
GN=RTG_02688 PE=3 SV=1
Length = 599
Score = 343 bits (881), Expect = 6e-92, Method: Compositional matrix adjust.
Identities = 166/351 (47%), Positives = 224/351 (63%), Gaps = 11/351 (3%)
Query: 17 RVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIV 76
R +SFEFFPPKT +G NL++R++RM P F DITWGAGGST++ T + +
Sbjct: 16 RPWWSFEFFPPKTPEGWVNLYDRIERMQQLGPIFVDITWGAGGSTSEATTNFVKTAHSEL 75
Query: 77 CVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDL 136
+ET +HLTCTNMPVE +D AL+ +G +N+LALRGDPP G +++ TEGGF A DL
Sbjct: 76 GLETCMHLTCTNMPVEMVDKALKATYDSGCRNILALRGDPPRGVEEWKPTEGGFNHAIDL 135
Query: 137 VKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQL 196
VKHIR YGDYF I VAG+PE HP +E+ + E+ + K KVDAGAD++ TQ+
Sbjct: 136 VKHIRKNYGDYFCIGVAGFPEGHPQ---------SESPEAEIRHFKKKVDAGADIVFTQM 186
Query: 197 FYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKD 256
FYD ++F+ + GIT PIVPGIMPI + F R T F T +P E+ LEPIKD
Sbjct: 187 FYDAEVFIDWGRRLRAAGITIPIVPGIMPIQTFAAFKRRTDFAGTIVPKELWDLLEPIKD 246
Query: 257 NEEAVKLYGIHLGTEMCRKILAH--GIKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
++ V+ G +MCRKIL GI +H YT+N+ + +L + + + + L
Sbjct: 247 DDAKVREVGTKYVADMCRKILNADLGIHGIHCYTMNLSRGTEMLLEEMQFVPTADRVKPL 306
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYG 365
PWR R E RPIFW+NR KSYI+RT WD++P+GRWGD+ +P++G
Sbjct: 307 PWRLSLTQKRRAETTRPIFWSNRQKSYITRTRDWDEFPNGRWGDASSPAFG 357
>H3CC89_TETNG (tr|H3CC89) Methylenetetrahydrofolate reductase OS=Tetraodon
nigroviridis GN=MTHFR PE=3 SV=1
Length = 660
Score = 343 bits (881), Expect = 6e-92, Method: Compositional matrix adjust.
Identities = 178/393 (45%), Positives = 248/393 (63%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G GS + + + IA+ N
Sbjct: 64 FSLEFFPPRTASGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 123
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N +KI L K GL+N++ALRGDP G D + + E GF A D
Sbjct: 124 CGLESILHLTCCNQTKDKITGYLGKAKRLGLKNIMALRGDP-VGAD-WEEEEDGFNYAID 181
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ DYF I VAGYP HP+A E+Y+ +L +LK KVDAGAD ++TQ
Sbjct: 182 LVKHIRSEFDDYFDICVAGYPTGHPEA---------ESYEQDLRHLKEKVDAGADFVITQ 232
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKF+ DC ++GITCP++PGI PI Y+ ++ K ++P EI + +EPIK
Sbjct: 233 LFFRAETFLKFLEDCRRVGITCPVLPGIFPIQGYQSLRQLVKLSKLELPEEITSIIEPIK 292
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YGI L +MCR +L G + LH YTLN E + + +L LGL IE+ + R
Sbjct: 293 DNDAAIRNYGIQLAVQMCRVLLDSGKVPGLHFYTLNREVATMEVLRQLGLWIEDPR--RP 350
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFW++RPKSYI RT WD +P+GRWG+S +P++G L DY
Sbjct: 351 LPWAVSAHPKRKVEDVRPIFWSSRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELNDYYLF 410
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ + L + W L S E ++ V Y+
Sbjct: 411 YLKSKSSKEALLQMWGEELLSEESVFEVFTCYI 443
>E4ZHE6_LEPMJ (tr|E4ZHE6) Methylenetetrahydrofolate reductase OS=Leptosphaeria
maculans (strain JN3 / isolate v23.1.3 / race
Av1-4-5-6-7-8) GN=LEMA_P057500.1 PE=3 SV=1
Length = 670
Score = 343 bits (880), Expect = 7e-92, Method: Compositional matrix adjust.
Identities = 171/389 (43%), Positives = 244/389 (62%), Gaps = 13/389 (3%)
Query: 19 VFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCV 78
FSFEFFPPKT GV NL++RMDRM P F DITWGAGG + +T E+ Q++ +
Sbjct: 17 TFSFEFFPPKTAQGVQNLYDRMDRMHGFGPQFIDITWGAGGRHSKLTCEMVKVAQSVYGL 76
Query: 79 ETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVK 138
ET +HLTCT+M K+D AL+ +G N+LALRGDPP ++K+ T GGF A+DLV
Sbjct: 77 ETCMHLTCTDMEKSKLDEALRDAYQSGCTNILALRGDPPREREKWEATAGGFRYAKDLVV 136
Query: 139 HIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFY 198
+IR +YG++F I VAGY E D D + + +LK KVDAGA IVTQ+FY
Sbjct: 137 YIRERYGNHFDIGVAGYSEGSDDNDNVDEL---------IDHLKEKVDAGATFIVTQMFY 187
Query: 199 DTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNE 258
DTDIFL++V G+ PI+PGIMPI+ + F+R + + IP ALEP+K+++
Sbjct: 188 DTDIFLEWVRKVRAKGVDVPIIPGIMPIHTHAAFLRRAQWTRCNIPQHWTEALEPVKNDD 247
Query: 259 EAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLI--EESKISRSLPW 316
V+ G L +MCRK++ GI LH YT+N+ ++ +L L L+ + S + + LPW
Sbjct: 248 VEVREVGKGLVADMCRKLIDAGILHLHFYTMNLAQATRMVLEELELLPDQRSPLEKPLPW 307
Query: 317 RRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPR 376
R + R E+VRPIFW NR +SY++RT WD++P+GRWGDS +P++G L Y + +
Sbjct: 308 RPSLGLNRREENVRPIFWRNRNRSYVARTQDWDEFPNGRWGDSRSPAFGELDSYG-IGLK 366
Query: 377 ARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ + W P+ SI D + + Y+Q
Sbjct: 367 GTNEQNIKLWGTPI-SIRDFSDLFVRYMQ 394
>F6Z4F8_MOUSE (tr|F6Z4F8) Methylenetetrahydrofolate reductase (Fragment) OS=Mus
musculus GN=Mthfr PE=2 SV=1
Length = 670
Score = 342 bits (878), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 172/392 (43%), Positives = 238/392 (60%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 75 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTAVNY 134
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N++ALRGDP D + EGGF+ A D
Sbjct: 135 CGLETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGDP--VGDHWEAEEGGFSYATD 192
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++ DYF I VAGYP HPDA E+++++L +LK KV AGAD I+TQ
Sbjct: 193 LVKHIRTEFADYFDICVAGYPRGHPDA---------ESFEDDLKHLKEKVSAGADFIITQ 243
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ F FV C +IGI+CPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 244 LFFEASTFFSFVKACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQKIKDVIEPIK 303
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++L G + LH YTLN E + + +L LG+ E R L
Sbjct: 304 DNDAAIRNYGIELAVSLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDP-RRPL 362
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 363 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFY 422
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 423 LKSKSPREELLKMWGEELTSEESVFEVFEHYL 454
>Q3UDB2_MOUSE (tr|Q3UDB2) Methylenetetrahydrofolate reductase OS=Mus musculus
GN=Mthfr PE=2 SV=1
Length = 695
Score = 342 bits (878), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 172/392 (43%), Positives = 238/392 (60%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N++ALRGDP D + EGGF+ A D
Sbjct: 160 CGLETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGDP--VGDHWEAEEGGFSYATD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++ DYF I VAGYP HPDA E+++++L +LK KV AGAD I+TQ
Sbjct: 218 LVKHIRTEFADYFDICVAGYPRGHPDA---------ESFEDDLKHLKEKVSAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ F FV C +IGI+CPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFEASTFFSFVKACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQKIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++L G + LH YTLN E + + +L LG+ E R L
Sbjct: 329 DNDAAIRNYGIELAVSLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDP-RRPL 387
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 388 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFY 447
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 448 LKSKSPREELLKMWGEELTSEESVFEVFEHYL 479
>A2A7F7_MOUSE (tr|A2A7F7) Methylenetetrahydrofolate reductase OS=Mus musculus
GN=Mthfr PE=3 SV=1
Length = 695
Score = 342 bits (878), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 172/392 (43%), Positives = 238/392 (60%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N++ALRGDP D + EGGF+ A D
Sbjct: 160 CGLETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGDP--VGDHWEAEEGGFSYATD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++ DYF I VAGYP HPDA E+++++L +LK KV AGAD I+TQ
Sbjct: 218 LVKHIRTEFADYFDICVAGYPRGHPDA---------ESFEDDLKHLKEKVSAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ F FV C +IGI+CPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFEASTFFSFVKACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQKIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++L G + LH YTLN E + + +L LG+ E R L
Sbjct: 329 DNDAAIRNYGIELAVSLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDP-RRPL 387
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 388 PWALSAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFY 447
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 448 LKSKSPREELLKMWGEELTSEESVFEVFEHYL 479
>F1RF82_PIG (tr|F1RF82) Methylenetetrahydrofolate reductase OS=Sus scrofa
GN=MTHFR PE=2 SV=1
Length = 700
Score = 342 bits (877), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 173/393 (44%), Positives = 245/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAQGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMVIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC + E++ L K GL+N+LALRGDP D++ EGGF+ A D
Sbjct: 160 CGLETILHMTCCHQSREEVTGYLHKAKRLGLKNILALRGDP--VGDQWEAEEGGFSYAAD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HPDA E+++ +L +LK KV AGAD I+TQ
Sbjct: 218 LVKHIRSEFGDYFDVCVAGYPKGHPDA---------ESFEADLKHLKEKVAAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +F+ C ++GITCPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFEADTFFRFLKACSEMGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YGI +C+++LA G + LH YTLN E + +L LGL IE+ + R
Sbjct: 329 DNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREVATTEVLKRLGLWIEDPR--RP 386
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY
Sbjct: 387 LPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLF 446
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ ++L + W L S E ++ V YL
Sbjct: 447 YLKSKSPKEELLKMWGQELTSEESVFEVFAHYL 479
>Q4T956_TETNG (tr|Q4T956) Methylenetetrahydrofolate reductase OS=Tetraodon
nigroviridis GN=GSTENG00004910001 PE=3 SV=1
Length = 845
Score = 342 bits (877), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 176/393 (44%), Positives = 245/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 64 FSLEFFPPRTASGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 123
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC N +KI L K GL+N++ALRGDP G D + + E GF A D
Sbjct: 124 CGLESILHLTCCNQTKDKITGYLGKAKRLGLKNIMALRGDP-VGAD-WEEEEDGFNYAID 181
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ DYF I VAGYP HP+A E+Y+ +L +LK KVDAGAD ++TQ
Sbjct: 182 LVKHIRSEFDDYFDICVAGYPTGHPEA---------ESYEQDLRHLKEKVDAGADFVITQ 232
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ + FLKF+ DC ++GITCP++PGI PI Y+ ++ K ++P EI + +EPIK
Sbjct: 233 LFFRAETFLKFLEDCRRVGITCPVLPGIFPIQGYQSLRQLVKLSKLELPEEITSIIEPIK 292
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YGI L +MCR +L G + LH YTLN E + + +L LGL IE+ + R
Sbjct: 293 DNDAAIRNYGIQLAVQMCRVLLDSGKVPGLHFYTLNREVATMEVLRQLGLWIEDPR--RP 350
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFW++RPKSYI RT WD +P+GRWG+S +P++G L DY
Sbjct: 351 LPWAVSAHPKRKVEDVRPIFWSSRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELNDYYLF 410
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ + L + W L S E ++ V Y+
Sbjct: 411 YLKSKSSKEALLQMWGEELLSEESVFEVFTCYI 443
>K9IVF1_PIG (tr|K9IVF1) Methylenetetrahydrofolate reductase OS=Sus scrofa
GN=MTHFR PE=2 SV=1
Length = 700
Score = 342 bits (877), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 173/393 (44%), Positives = 245/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAQGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMVIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC + E++ L K GL+N+LALRGDP D++ EGGF+ A D
Sbjct: 160 CGLETILHMTCCHQSREEVTGYLHKAKRLGLKNILALRGDP--VGDQWEAEEGGFSYAAD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HPDA E+++ +L +LK KV AGAD I+TQ
Sbjct: 218 LVKHIRSEFGDYFDVCVAGYPKGHPDA---------ESFEADLKHLKEKVAAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +F+ C ++GITCPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFEADTFFRFLKACSEMGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YGI +C+++LA G + LH YTLN E + +L LGL IE+ + R
Sbjct: 329 DNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREVATTEVLKRLGLWIEDPR--RP 386
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY
Sbjct: 387 LPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLF 446
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ ++L + W L S E ++ V YL
Sbjct: 447 YLKSKSPKEELLKMWGQELTSEESVFEVFAHYL 479
>F9XCC6_MYCGM (tr|F9XCC6) Methylenetetrahydrofolate reductase OS=Mycosphaerella
graminicola (strain CBS 115943 / IPO323)
GN=MYCGRDRAFT_109648 PE=3 SV=1
Length = 639
Score = 342 bits (876), Expect = 2e-91, Method: Compositional matrix adjust.
Identities = 170/395 (43%), Positives = 251/395 (63%), Gaps = 21/395 (5%)
Query: 18 VVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVC 77
+SFE+FPPKT GV NL++RMD M P+F DITWGAGG + +T E+ Q+
Sbjct: 16 ATYSFEYFPPKTAQGVQNLYDRMDMMHGFGPAFIDITWGAGGRHSSLTCEMVKVAQSAYG 75
Query: 78 VETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLV 137
+ET +HLTCT+M + K+D+AL+ + G N+LALRGDPP Q+K+V+T+GGF ARDL+
Sbjct: 76 LETCMHLTCTDMELSKVDDALKEAYNAGCTNILALRGDPPREQEKWVETQGGFRYARDLI 135
Query: 138 KHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLF 197
K+I+ KYGD+F I +AGYPE G D T + + + YLK KVDAG +V Q+
Sbjct: 136 KYIKKKYGDHFDIGIAGYPE------GPDETTTADEH---IVYLKEKVDAGGTFVVAQMC 186
Query: 198 YDTDIFLKFVNDCLQIGI--TCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
YD ++F+++V C GI + PI+PGIMPI+ + FIR + + +IP ALEPIK
Sbjct: 187 YDAELFIEWVQKCRDAGIPESVPIIPGIMPISTHAAFIRRANWTQARIPPAWHEALEPIK 246
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIEESKIS---- 311
+++ AV+ G L E C+K++A GI LH YT+N+ + +L L L ++
Sbjct: 247 NDDSAVREVGRDLIVEFCQKLMAAGIMHLHFYTMNLAAAVRMVLEKLDLTPSAESPHPDI 306
Query: 312 RSLPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDY- 370
+ LPWR+ + R E+VRPIFW NR ++Y++RT WD++P+GRWGDS +P++G+L +Y
Sbjct: 307 KPLPWRQSLGLNRRDENVRPIFWRNRNRAYVARTQDWDEFPNGRWGDSRSPAFGSLDEYG 366
Query: 371 -QFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++KL W P ++I+DI + + Y+
Sbjct: 367 IGLKGTNEHNRKL---WGEP-QTIDDISKLFVKYM 397
>G3IHM4_CRIGR (tr|G3IHM4) Methylenetetrahydrofolate reductase OS=Cricetulus
griseus GN=I79_023316 PE=3 SV=1
Length = 644
Score = 341 bits (875), Expect = 3e-91, Method: Compositional matrix adjust.
Identities = 172/392 (43%), Positives = 240/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 49 FSLEFFPPRTAEGAVNLISRFDRMAAGGPLFLDVTWHPAGDPGSDKETFSMMIASTAVNY 108
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N++ALRGDP D + EGGF+ A D
Sbjct: 109 CGLETVLHVTCCQQRQEEITGHLHKAKQLGLKNIMALRGDPV--GDHWETEEGGFSYATD 166
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HP+A E+++ +L +LK KV AGAD I+TQ
Sbjct: 167 LVKHIRSEFGDYFDICVAGYPKGHPEA---------ESFEEDLKHLKEKVSAGADFIITQ 217
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ + FL FV C +IGI+CPI+PGI PI Y ++ K ++P I +EPIK
Sbjct: 218 LFFEANTFLSFVKACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQNIKDVIEPIK 277
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L +CR++L G + LH YTLN E + + +L LG+ E R L
Sbjct: 278 DNDAAIRNYGIELAVSLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDP-RRPL 336
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R E VRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 337 PWAVSAHPKRREEYVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFY 396
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 397 LKSKSPREELLKMWGEELTSEESVFKVFERYL 428
>R0K2D2_SETTU (tr|R0K2D2) Uncharacterized protein OS=Setosphaeria turcica Et28A
GN=SETTUDRAFT_93247 PE=4 SV=1
Length = 654
Score = 341 bits (875), Expect = 3e-91, Method: Compositional matrix adjust.
Identities = 172/389 (44%), Positives = 246/389 (63%), Gaps = 13/389 (3%)
Query: 19 VFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADVTLEIANKMQNIVCV 78
FSFEFFPPKT GV NL++RMDRM + P F D+TWGAGG + +T E+ Q++ +
Sbjct: 17 TFSFEFFPPKTAQGVQNLYDRMDRMHSFGPQFIDLTWGAGGRHSKLTCEMVKVAQSVYGL 76
Query: 79 ETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARDLVK 138
ET +HLTCT+M K+D+AL+ G N+LALRGDPP ++K+ T GGF A+DLV
Sbjct: 77 ETCMHLTCTDMEKSKLDDALKEAYQAGCTNILALRGDPPREREKWEATAGGFRYAKDLVV 136
Query: 139 HIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQLFY 198
+I+ KYG++F I VAGY E D D + + +LK KVDAGA +VTQ+FY
Sbjct: 137 YIKEKYGNHFDIGVAGYSEGCDDNDNVDEL---------IDHLKEKVDAGATFVVTQMFY 187
Query: 199 DTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNE 258
DTDIFL++V GI PI+PGIMPI+ + F+R + + IP ALEPIK+++
Sbjct: 188 DTDIFLEWVRKVRAKGIDVPIIPGIMPIHTHAAFLRRAQWTRCHIPKHWEEALEPIKNDD 247
Query: 259 EAVKLYGIHLGTEMCRKILAHGIKTLHLYTLNMEKSALAILTSLGLIE--ESKISRSLPW 316
V+ G L +MCR+++ GI LH YT+N+ ++ +L L L+ ES + + LPW
Sbjct: 248 VEVREVGKTLVADMCRRLIEAGITHLHFYTMNLAQATRMVLEELELLPDVESPLEKPLPW 307
Query: 317 RRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQFMRPR 376
R + R E+VRPIFW NR +SYI+RT WD++P+GRWGDS +P++G L Y + +
Sbjct: 308 RPSLALNRRDENVRPIFWRNRNRSYIARTQDWDEFPNGRWGDSRSPAFGELDSYG-IGLK 366
Query: 377 ARDKKLTEEWAVPLRSIEDIYVVGLLYLQ 405
+++ + W PL SI D+ + + Y++
Sbjct: 367 GTNEQNIKLWGTPL-SIRDLSNLFVRYME 394
>D2HKB9_AILME (tr|D2HKB9) Methylenetetrahydrofolate reductase (Fragment)
OS=Ailuropoda melanoleuca GN=PANDA_011818 PE=3 SV=1
Length = 694
Score = 341 bits (874), Expect = 3e-91, Method: Compositional matrix adjust.
Identities = 175/393 (44%), Positives = 245/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAEGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L + GL+N+LALRGDP D++ + EGGF+ A D
Sbjct: 160 CGLETILHMTCCCQSREQITGYLHKARRLGLKNILALRGDP--VGDQWEEEEGGFSYAAD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LV+HIR+++GDYF I VAGYP+ HPDA GS ++ +L YLK KV AGAD I+TQ
Sbjct: 218 LVRHIRSEFGDYFDICVAGYPKGHPDA-GS--------FEADLKYLKEKVSAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +IGITCPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFEADTFFQFVKACSEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YGI +C+++L G + LH YTLN E + +L LG+ IE+ + R
Sbjct: 329 DNDAAIRNYGIEQAVSLCQQLLTSGLVPGLHFYTLNREMATTEVLKRLGMWIEDPR--RP 386
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY
Sbjct: 387 LPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLF 446
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ ++L + W L S E ++ V YL
Sbjct: 447 YLKSKSPREELLKMWGEELTSEESVFEVFAHYL 479
>G1LTB1_AILME (tr|G1LTB1) Methylenetetrahydrofolate reductase OS=Ailuropoda
melanoleuca GN=MTHFR PE=3 SV=1
Length = 695
Score = 341 bits (874), Expect = 3e-91, Method: Compositional matrix adjust.
Identities = 175/393 (44%), Positives = 245/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAEGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L + GL+N+LALRGDP D++ + EGGF+ A D
Sbjct: 160 CGLETILHMTCCCQSREQITGYLHKARRLGLKNILALRGDP--VGDQWEEEEGGFSYAAD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LV+HIR+++GDYF I VAGYP+ HPDA GS ++ +L YLK KV AGAD I+TQ
Sbjct: 218 LVRHIRSEFGDYFDICVAGYPKGHPDA-GS--------FEADLKYLKEKVSAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F +FV C +IGITCPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 269 LFFEADTFFQFVKACSEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YGI +C+++L G + LH YTLN E + +L LG+ IE+ + R
Sbjct: 329 DNDAAIRNYGIEQAVSLCQQLLTSGLVPGLHFYTLNREMATTEVLKRLGMWIEDPR--RP 386
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY
Sbjct: 387 LPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLF 446
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ ++L + W L S E ++ V YL
Sbjct: 447 YLKSKSPREELLKMWGEELTSEESVFEVFAHYL 479
>M3YY87_MUSPF (tr|M3YY87) Methylenetetrahydrofolate reductase OS=Mustela putorius
furo GN=Mthfr PE=3 SV=1
Length = 654
Score = 341 bits (874), Expect = 3e-91, Method: Compositional matrix adjust.
Identities = 177/393 (45%), Positives = 245/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T +G NL R DRM A P F D+TW G ++ IA+ N
Sbjct: 59 FSLEFFPPRTAEGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 118
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC +I L K GL+N+LALRGDP D++ + EGGF+ A D
Sbjct: 119 CGLETILHMTCCCQNQGQITGYLHKAKRLGLKNILALRGDPVG--DQWEEEEGGFSYAAD 176
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF I VAGYP+ HPDA GS ++ +L YLK KV AGAD I+TQ
Sbjct: 177 LVKHIRSEFGDYFDICVAGYPKGHPDA-GS--------FEADLKYLKEKVSAGADFIITQ 227
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F FV C +IGITCPI+PGI PI Y ++ K ++P +I +EPIK
Sbjct: 228 LFFEADTFFHFVKACSEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIK 287
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN++A++ YGI +C+++LA G + LH YTLN E + +L LG+ IE+ + R
Sbjct: 288 DNDDAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWIEDPR--RP 345
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY
Sbjct: 346 LPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLF 405
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ ++L + W L S E ++ V YL
Sbjct: 406 YLKSKSPREELLKMWGEELTSEESVFEVFAHYL 438
>J7R7R4_KAZNA (tr|J7R7R4) Methylenetetrahydrofolate reductase OS=Kazachstania
naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797
/ CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082)
GN=KNAG0F02500 PE=3 SV=1
Length = 610
Score = 341 bits (874), Expect = 4e-91, Method: Compositional matrix adjust.
Identities = 182/418 (43%), Positives = 251/418 (60%), Gaps = 33/418 (7%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ +K+ + FSFE+F PKTE GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITDKLHSYHELS-GKPTFSFEYFVPKTEQGVQNLYDRMDRMYEASLPQFVDITWNAGG 59
Query: 60 STADVTLEIANK-------MQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLAL 112
+ I + Q+++ +ET +HLTCTNMPV++IDNAL++ +G QN+LAL
Sbjct: 60 GSNSTNRGITQQSTDLVATAQSVLGLETCMHLTCTNMPVQQIDNALESAFQSGCQNLLAL 119
Query: 113 RGDPPHGQ------DKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSD 166
RGDPP G D++ EGGF A DLV++IRAKYGD+F I VAGYPE HP+
Sbjct: 120 RGDPPRGPLGGGDGDEWQPVEGGFRHASDLVRYIRAKYGDHFNIGVAGYPEGHPEE---- 175
Query: 167 GVATTEAYQNELTYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPI 226
+ +N L YL+ KVDAGAD I+TQ+FYD F+++ Q G+ PI+PGIMPI
Sbjct: 176 -----KNPENNLLYLREKVDAGADFIITQMFYDAGRFVEWCRQVRQAGVEVPIIPGIMPI 230
Query: 227 NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLH 285
+ F+R + IP + L PIKD++E V+ G L +MC+ +L G + LH
Sbjct: 231 TTFAAFLRRASWGSVHIPQRFLDVLTPIKDDDELVREMGTALVVQMCQTVLDSGYVNHLH 290
Query: 286 LYTLNMEKSALAILTSLGLIEESKI-----SRSLPWRRPTNVFRVREDVRPIFWANRPKS 340
+YT+N+EK+ L IL L L+ + LPWR+ N R RE+VRPIFW RP S
Sbjct: 291 IYTMNLEKAPLMILERLRLLPTDAELVGTGASLLPWRKSLNPNRRREEVRPIFWKKRPYS 350
Query: 341 YISRTIGW--DQYPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDI 396
Y++RT W D++P+GR+GDS +P++G L R K+ E W+ P R++ D+
Sbjct: 351 YVARTSQWAEDEFPNGRFGDSSSPAFGDLDLCGSSLIRQSRKRALELWSTP-RTLNDL 407
>Q7ZWU2_XENLA (tr|Q7ZWU2) Methylenetetrahydrofolate reductase OS=Xenopus laevis
GN=mthfr PE=2 SV=1
Length = 643
Score = 341 bits (874), Expect = 4e-91, Method: Compositional matrix adjust.
Identities = 173/392 (44%), Positives = 240/392 (61%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R DRM + P F D+TW G ++ IA+ N
Sbjct: 54 FSLEFFPPRTASGAVNLISRFDRMGSGGPLFIDVTWHPAGDPGSDKETSSMIIASTAVNF 113
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC N E I LQ K GL+N++ALRGDP +++ + GF A D
Sbjct: 114 CGLETLLHMTCCNQTKEDITKHLQKAKRLGLKNIMALRGDP--TGEEWEEEAEGFNYAVD 171
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR ++ DYF I VAGYP HPDA E+Y +L +LK K+DAGAD I+TQ
Sbjct: 172 LVKHIRHEFEDYFDICVAGYPRGHPDA---------ESYDQDLKHLKEKIDAGADFIITQ 222
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ ++ FL F+ DC IGITCP++PGI PI Y ++ K ++P EIM +EPIK
Sbjct: 223 LFFRSETFLTFLKDCRAIGITCPVLPGIFPIQGYGSLRQLVKLSKLEVPQEIMDVIEPIK 282
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI L MCR++L G + LH YTLN E + + +L LG+ +E R +
Sbjct: 283 DNDAAIRNYGIDLAVSMCRELLDSGLVHGLHFYTLNREVATIDVLKRLGMWKEDP-RRPM 341
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA+RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 342 PWAMSAHPKRRVEDVRPIFWASRPKSYIHRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 401
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V Y+
Sbjct: 402 LKSKSPREELLKMWGQELNSEESVFEVFTYYI 433
>F7CPK1_HORSE (tr|F7CPK1) Methylenetetrahydrofolate reductase OS=Equus caballus
GN=MTHFR PE=3 SV=1
Length = 696
Score = 340 bits (873), Expect = 4e-91, Method: Compositional matrix adjust.
Identities = 173/392 (44%), Positives = 239/392 (60%), Gaps = 19/392 (4%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTAD----VTLEIANKMQNI 75
FS EFFPP+T G NL R D+M A P F D+TW G ++ IA+ N
Sbjct: 100 FSLEFFPPRTAQGAVNLISRFDQMGAGGPLFIDVTWHPAGDPGSDKETSSMMIASTAVNY 159
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+ET++H+TC E+I L K GL+N+LALRGDP D++ + EGGF+ A D
Sbjct: 160 CGLETVLHMTCCRQSREEITGYLHKAKRLGLKNILALRGDP--VGDQWEEEEGGFSYAAD 217
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++GDYF + VAGYP+ HPD + +++ +L YLK KV AGAD I+TQ
Sbjct: 218 LVKHIRSEFGDYFDVCVAGYPKGHPD---------SGSFEADLKYLKEKVSAGADFIITQ 268
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF++ D F FV C +IGITCPI+PGI PI Y ++ K ++P EI +EPIK
Sbjct: 269 LFFEADTFFHFVKACSEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIK 328
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGLIEESKISRSL 314
DN+ A++ YGI +C+++LA G + LH YTLN E + +L LG+ E R L
Sbjct: 329 DNDGAIRNYGIDQAVSLCQQLLASGLVPGLHFYTLNREVATTEVLKRLGMWVEDP-RRPL 387
Query: 315 PWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ--F 372
PW + R EDVRPIFWA RPKSYI RT WD++P+GRWG+S +P++G L DY +
Sbjct: 388 PWALSAHPKRREEDVRPIFWATRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFY 447
Query: 373 MRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
++ ++ ++L + W L S E ++ V YL
Sbjct: 448 LKSKSPKEELLKMWGEELTSEESVFEVFAHYL 479
>C8Z8C5_YEAS8 (tr|C8Z8C5) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain Lalvin EC1118 / Prise de mousse)
GN=EC1118_1G1_1585g PE=3 SV=1
Length = 600
Score = 340 bits (873), Expect = 5e-91, Method: Compositional matrix adjust.
Identities = 179/414 (43%), Positives = 255/414 (61%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ Q+++ +ET +HLTCTNMP+ ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+ + EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKD-------VKLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + + G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G + LH+YT+N+EK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLI-EESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R K E W+ P SI D+ + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYL 405
>G3PGI0_GASAC (tr|G3PGI0) Methylenetetrahydrofolate reductase OS=Gasterosteus
aculeatus GN=MTHFR PE=3 SV=1
Length = 655
Score = 340 bits (873), Expect = 5e-91, Method: Compositional matrix adjust.
Identities = 181/393 (46%), Positives = 246/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM + P F DITW G GS + + + IA+ N
Sbjct: 59 FSLEFFPPRTASGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 118
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC + KI L K GL+N++ALRGDP G D + + E GF A D
Sbjct: 119 CGLESILHLTCCDQTKGKITGYLAKAKHLGLKNIMALRGDP-IGAD-WEEEEEGFNYATD 176
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ DYF I VAGYP HP+A E+Y+++L +LK KVDAGAD I+TQ
Sbjct: 177 LVKHIRSEFEDYFDICVAGYPTGHPEA---------ESYEDDLRHLKEKVDAGADFIITQ 227
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ D FLKF++DC IGITCPI+PGI PI Y+ ++ K +IP EI +EPIK
Sbjct: 228 LFFRADTFLKFLDDCRAIGITCPILPGIFPIQGYQSLRQLVKLSKLEIPEEITRVIEPIK 287
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YG+ EMCR +L G + LH YTLN E + + +L LGL IE+ + R
Sbjct: 288 DNDAAIRNYGVQQAVEMCRVLLDSGKVPGLHFYTLNREVAIMEVLRQLGLWIEDPR--RP 345
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD +P+GRWG+S +P++G L DY
Sbjct: 346 LPWAVSAHPKRKVEDVRPIFWASRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELNDYYLF 405
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ L + W L++ E ++ V Y+
Sbjct: 406 YLKSKSPKDALLQMWGDELKNEESVFEVFTCYI 438
>E7LU98_YEASV (tr|E7LU98) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain VIN 13) GN=VIN13_1661 PE=3 SV=1
Length = 600
Score = 340 bits (873), Expect = 5e-91, Method: Compositional matrix adjust.
Identities = 179/414 (43%), Positives = 255/414 (61%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ Q+++ +ET +HLTCTNMP+ ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+ + EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKD-------VKLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + + G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G + LH+YT+N+EK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLIE-ESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPMESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R K E W+ P SI D+ + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYL 405
>E7KCE7_YEASA (tr|E7KCE7) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain AWRI796) GN=AWRI796_1678 PE=3 SV=1
Length = 600
Score = 340 bits (873), Expect = 5e-91, Method: Compositional matrix adjust.
Identities = 179/414 (43%), Positives = 255/414 (61%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ Q+++ +ET +HLTCTNMP+ ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+ + EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKD-------VKLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + + G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G + LH+YT+N+EK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLIE-ESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPMESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R K E W+ P SI D+ + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYL 405
>B3LHI5_YEAS1 (tr|B3LHI5) Methylenetetrahydrofolate reductase OS=Saccharomyces
cerevisiae (strain RM11-1a) GN=SCRG_01120 PE=3 SV=1
Length = 600
Score = 340 bits (873), Expect = 5e-91, Method: Compositional matrix adjust.
Identities = 179/414 (43%), Positives = 255/414 (61%), Gaps = 19/414 (4%)
Query: 1 MKVIEKVRXXXXXDPDRVVFSFEFFPPKTEDGVDNLFERMDRMV-AHNPSFCDITWGAGG 59
MK+ EK+ + +SFE+F PKT GV NL++RMDRM A P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTS-GKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGG 59
Query: 60 S-TADVTLEIANKMQNIVCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPH 118
+ ++ ++ Q+++ +ET +HLTCTNMP+ ID+AL+ +G QN+LALRGDPP
Sbjct: 60 GRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPR 119
Query: 119 GQDKFVQTEGGFACARDLVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNEL 178
+ + EGGF A+DL+K+I++KYGD+F I VAGYPE HP+ D + +L
Sbjct: 120 DAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKD-------VKLDL 172
Query: 179 TYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGF 238
YLK K+DAG D I+TQ+FYD D F+ + + G+ PI+PGIMPI Y F+R +
Sbjct: 173 EYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQW 232
Query: 239 CKTKIPAEIMAALEPIKDNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALA 297
+ IP + L+PIKD++E V+ G +L EMC+K+L G + LH+YT+N+EK+ L
Sbjct: 233 GQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLM 292
Query: 298 ILTSLGLIE-ESKISRS----LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGW--DQ 350
IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY++RT W D+
Sbjct: 293 ILERLNILPMESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDE 352
Query: 351 YPHGRWGDSGNPSYGALTDYQFMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+P+GR+GDS +P++G L R K E W+ P SI D+ + + YL
Sbjct: 353 FPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYL 405
>G3PGH6_GASAC (tr|G3PGH6) Methylenetetrahydrofolate reductase (Fragment)
OS=Gasterosteus aculeatus GN=MTHFR PE=3 SV=1
Length = 650
Score = 340 bits (873), Expect = 5e-91, Method: Compositional matrix adjust.
Identities = 181/393 (46%), Positives = 246/393 (62%), Gaps = 21/393 (5%)
Query: 20 FSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITW---GAGGSTADVT-LEIANKMQNI 75
FS EFFPP+T G NL R DRM + P F DITW G GS + + + IA+ N
Sbjct: 54 FSLEFFPPRTASGAVNLISRFDRMGSGGPLFIDITWHPAGDPGSDKETSSMMIASTAVNY 113
Query: 76 VCVETMIHLTCTNMPVEKIDNALQTIKSNGLQNVLALRGDPPHGQDKFVQTEGGFACARD 135
+E+++HLTC + KI L K GL+N++ALRGDP G D + + E GF A D
Sbjct: 114 CGLESILHLTCCDQTKGKITGYLAKAKHLGLKNIMALRGDP-IGAD-WEEEEEGFNYATD 171
Query: 136 LVKHIRAKYGDYFGITVAGYPEAHPDAIGSDGVATTEAYQNELTYLKSKVDAGADLIVTQ 195
LVKHIR+++ DYF I VAGYP HP+A E+Y+++L +LK KVDAGAD I+TQ
Sbjct: 172 LVKHIRSEFEDYFDICVAGYPTGHPEA---------ESYEDDLRHLKEKVDAGADFIITQ 222
Query: 196 LFYDTDIFLKFVNDCLQIGITCPIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIK 255
LF+ D FLKF++DC IGITCPI+PGI PI Y+ ++ K +IP EI +EPIK
Sbjct: 223 LFFRADTFLKFLDDCRAIGITCPILPGIFPIQGYQSLRQLVKLSKLEIPEEITRVIEPIK 282
Query: 256 DNEEAVKLYGIHLGTEMCRKILAHG-IKTLHLYTLNMEKSALAILTSLGL-IEESKISRS 313
DN+ A++ YG+ EMCR +L G + LH YTLN E + + +L LGL IE+ + R
Sbjct: 283 DNDAAIRNYGVQQAVEMCRVLLDSGKVPGLHFYTLNREVAIMEVLRQLGLWIEDPR--RP 340
Query: 314 LPWRRPTNVFRVREDVRPIFWANRPKSYISRTIGWDQYPHGRWGDSGNPSYGALTDYQ-- 371
LPW + R EDVRPIFWA+RPKSYI RT WD +P+GRWG+S +P++G L DY
Sbjct: 341 LPWAVSAHPKRKVEDVRPIFWASRPKSYIYRTQDWDDFPNGRWGNSSSPAFGELNDYYLF 400
Query: 372 FMRPRARDKKLTEEWAVPLRSIEDIYVVGLLYL 404
+++ ++ L + W L++ E ++ V Y+
Sbjct: 401 YLKSKSPKDALLQMWGDELKNEESVFEVFTCYI 433