Miyakogusa Predicted Gene

Lj3g3v0826110.1
Show Alignment: 

BLASTP 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= Lj3g3v0826110.1 tr|I1MJQ7|I1MJQ7_SOYBN DNA topoisomerase 2
OS=Glycine max GN=Gma.43351 PE=3 SV=1,86.8,0,DNA_topoisoIV,DNA
topoisomerase, type IIA, subunit A/C-terminal; Toprim,Toprim domain;
TOPISMRASEII,,CUFF.41569.1
         (857 letters)

Database: trembl 
           41,451,118 sequences; 13,208,986,710 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

I1MJQ7_SOYBN (tr|I1MJQ7) DNA topoisomerase 2 OS=Glycine max PE=3...  1429   0.0  
I1L9S4_SOYBN (tr|I1L9S4) DNA topoisomerase 2 OS=Glycine max PE=3...  1358   0.0  
G7IWV9_MEDTR (tr|G7IWV9) DNA topoisomerase 2 OS=Medicago truncat...  1331   0.0  
G7J2H1_MEDTR (tr|G7J2H1) DNA topoisomerase 2 OS=Medicago truncat...  1197   0.0  
F6HBC4_VITVI (tr|F6HBC4) DNA topoisomerase 2 OS=Vitis vinifera G...  1119   0.0  
M5X8I4_PRUPE (tr|M5X8I4) Uncharacterized protein OS=Prunus persi...  1105   0.0  
Q8GSC4_TOBAC (tr|Q8GSC4) DNA topoisomerase 2 OS=Nicotiana tabacu...  1063   0.0  
M1A903_SOLTU (tr|M1A903) DNA topoisomerase 2 OS=Solanum tuberosu...  1060   0.0  
M1A904_SOLTU (tr|M1A904) DNA topoisomerase 2 OS=Solanum tuberosu...  1059   0.0  
K4AYE0_SOLLC (tr|K4AYE0) DNA topoisomerase 2 OS=Solanum lycopers...  1058   0.0  
M0T361_MUSAM (tr|M0T361) DNA topoisomerase 2 OS=Musa acuminata s...  1053   0.0  
Q2L363_MALDO (tr|Q2L363) DNA topoisomerase 2 OS=Malus domestica ...  1047   0.0  
M0SVF6_MUSAM (tr|M0SVF6) DNA topoisomerase 2 OS=Musa acuminata s...  1047   0.0  
B9HNR6_POPTR (tr|B9HNR6) DNA topoisomerase 2 OS=Populus trichoca...  1033   0.0  
A9RWX5_PHYPA (tr|A9RWX5) DNA topoisomerase 2 (Fragment) OS=Physc...  1026   0.0  
A9SRT5_PHYPA (tr|A9SRT5) DNA topoisomerase 2 (Fragment) OS=Physc...  1025   0.0  
D8SXJ0_SELML (tr|D8SXJ0) DNA topoisomerase 2 OS=Selaginella moel...  1024   0.0  
M4D3L7_BRARP (tr|M4D3L7) DNA topoisomerase 2 OS=Brassica rapa su...  1023   0.0  
D8RNR7_SELML (tr|D8RNR7) DNA topoisomerase 2 OS=Selaginella moel...  1023   0.0  
D8TGD2_SELML (tr|D8TGD2) DNA topoisomerase 2 (Fragment) OS=Selag...  1023   0.0  
J3LG54_ORYBR (tr|J3LG54) DNA topoisomerase 2 OS=Oryza brachyanth...  1019   0.0  
B9GFC4_POPTR (tr|B9GFC4) DNA topoisomerase 2 OS=Populus trichoca...  1019   0.0  
Q6Z8D9_ORYSJ (tr|Q6Z8D9) DNA topoisomerase 2 OS=Oryza sativa sub...  1018   0.0  
R0G2R4_9BRAS (tr|R0G2R4) Uncharacterized protein OS=Capsella rub...  1018   0.0  
I1P3D3_ORYGL (tr|I1P3D3) DNA topoisomerase 2 OS=Oryza glaberrima...  1010   0.0  
M7Z036_TRIUA (tr|M7Z036) DNA topoisomerase 2 OS=Triticum urartu ...  1006   0.0  
N1QSK5_AEGTA (tr|N1QSK5) DNA topoisomerase 2 OS=Aegilops tauschi...  1002   0.0  
M8BEA6_AEGTA (tr|M8BEA6) Uncharacterized protein OS=Aegilops tau...  1000   0.0  
Q4JF74_SCUBA (tr|Q4JF74) DNA topoisomerase 2 OS=Scutellaria baic...   999   0.0  
C5Y0E7_SORBI (tr|C5Y0E7) DNA topoisomerase 2 OS=Sorghum bicolor ...   999   0.0  
B9RVN3_RICCO (tr|B9RVN3) DNA topoisomerase II, putative OS=Ricin...   998   0.0  
I1ICW7_BRADI (tr|I1ICW7) DNA topoisomerase 2 OS=Brachypodium dis...   998   0.0  
I1ICW6_BRADI (tr|I1ICW6) DNA topoisomerase 2 OS=Brachypodium dis...   998   0.0  
K3YP99_SETIT (tr|K3YP99) DNA topoisomerase 2 OS=Setaria italica ...   996   0.0  
B3H4G2_ARATH (tr|B3H4G2) DNA topoisomerase 2 OS=Arabidopsis thal...   977   0.0  
D7L459_ARALL (tr|D7L459) DNA topoisomerase 2 OS=Arabidopsis lyra...   975   0.0  
M8AFG0_TRIUA (tr|M8AFG0) DNA topoisomerase 2 OS=Triticum urartu ...   957   0.0  
A3AAF2_ORYSJ (tr|A3AAF2) DNA topoisomerase 2 OS=Oryza sativa sub...   924   0.0  
A2X8M2_ORYSI (tr|A2X8M2) DNA topoisomerase 2 OS=Oryza sativa sub...   917   0.0  
M1A902_SOLTU (tr|M1A902) DNA topoisomerase 2 OS=Solanum tuberosu...   876   0.0  
E1Z4H4_CHLVA (tr|E1Z4H4) DNA topoisomerase 2 OS=Chlorella variab...   873   0.0  
C1E5N4_MICSR (tr|C1E5N4) DNA topoisomerase 2 OS=Micromonas sp. (...   864   0.0  
C1MN24_MICPC (tr|C1MN24) DNA topoisomerase 2 OS=Micromonas pusil...   863   0.0  
D8U578_VOLCA (tr|D8U578) DNA topoisomerase 2 OS=Volvox carteri G...   857   0.0  
I0YZH1_9CHLO (tr|I0YZH1) DNA topoisomerase 2 OS=Coccomyxa subell...   853   0.0  
A8JD08_CHLRE (tr|A8JD08) DNA topoisomerase 2 (Fragment) OS=Chlam...   852   0.0  
A4S645_OSTLU (tr|A4S645) DNA topoisomerase 2 OS=Ostreococcus luc...   843   0.0  
G0T007_RHOG2 (tr|G0T007) DNA topoisomerase 2 OS=Rhodotorula glut...   834   0.0  
M7WCM6_RHOTO (tr|M7WCM6) DNA topoisomerase II OS=Rhodosporidium ...   832   0.0  
K3X2K0_PYTUL (tr|K3X2K0) DNA topoisomerase 2 OS=Pythium ultimum ...   828   0.0  
Q0DYE1_ORYSJ (tr|Q0DYE1) DNA topoisomerase 2 (Fragment) OS=Oryza...   822   0.0  
Q0PWB2_PLEOS (tr|Q0PWB2) DNA topoisomerase 2 OS=Pleurotus ostrea...   822   0.0  
E6R0Q0_CRYGW (tr|E6R0Q0) DNA topoisomerase 2 OS=Cryptococcus gat...   822   0.0  
Q5KP97_CRYNJ (tr|Q5KP97) DNA topoisomerase 2 OS=Cryptococcus neo...   821   0.0  
F5HDJ4_CRYNB (tr|F5HDJ4) DNA topoisomerase 2 OS=Cryptococcus neo...   821   0.0  
J4ICG2_FIBRA (tr|J4ICG2) DNA topoisomerase 2 OS=Fibroporia radic...   811   0.0  
K5XBZ3_PHACS (tr|K5XBZ3) DNA topoisomerase 2 OS=Phanerochaete ca...   808   0.0  
I2FWY2_USTH4 (tr|I2FWY2) DNA topoisomerase 2 OS=Ustilago hordei ...   808   0.0  
H3G7M6_PHYRM (tr|H3G7M6) DNA topoisomerase 2 (Fragment) OS=Phyto...   806   0.0  
F2U845_SALS5 (tr|F2U845) DNA topoisomerase 2 OS=Salpingoeca sp. ...   805   0.0  
F2U844_SALS5 (tr|F2U844) DNA topoisomerase 2 OS=Salpingoeca sp. ...   805   0.0  
M7NQN5_9ASCO (tr|M7NQN5) Uncharacterized protein OS=Pneumocystis...   803   0.0  
K8F0A4_9CHLO (tr|K8F0A4) DNA topoisomerase 2 OS=Bathycoccus pras...   803   0.0  
Q00XH2_OSTTA (tr|Q00XH2) DNA topoisomerase 2 OS=Ostreococcus tau...   801   0.0  
E9C0T0_CAPO3 (tr|E9C0T0) DNA topoisomerase 2 OS=Capsaspora owcza...   801   0.0  
G5AAW7_PHYSP (tr|G5AAW7) DNA topoisomerase 2 (Fragment) OS=Phyto...   800   0.0  
L1IRG4_GUITH (tr|L1IRG4) DNA topoisomerase 2 OS=Guillardia theta...   799   0.0  
M2RR97_CERSU (tr|M2RR97) DNA topoisomerase 2 OS=Ceriporiopsis su...   798   0.0  
R7SSV1_DICSQ (tr|R7SSV1) Type II DNA topoisomerase OS=Dichomitus...   798   0.0  
E3JRR8_PUCGT (tr|E3JRR8) DNA topoisomerase 2 OS=Puccinia gramini...   797   0.0  
A1IGC8_COPCI (tr|A1IGC8) DNA topoisomerase 2 OS=Coprinopsis cine...   795   0.0  
Q5KSK9_COPCI (tr|Q5KSK9) DNA topoisomerase 2 OS=Coprinopsis cine...   795   0.0  
A8N230_COPC7 (tr|A8N230) DNA topoisomerase 2 OS=Coprinopsis cine...   795   0.0  
R9NYN7_9BASI (tr|R9NYN7) DNA topoisomerase II OS=Pseudozyma hube...   793   0.0  
F8QG51_SERL3 (tr|F8QG51) DNA topoisomerase 2 OS=Serpula lacryman...   791   0.0  
Q4P8R2_USTMA (tr|Q4P8R2) DNA topoisomerase 2 OS=Ustilago maydis ...   791   0.0  
K9IC41_AGABB (tr|K9IC41) DNA topoisomerase 2 OS=Agaricus bisporu...   791   0.0  
F0WKX4_9STRA (tr|F0WKX4) DNA topoisomerase 2 OS=Albugo laibachii...   790   0.0  
K5Y6A9_AGABU (tr|K5Y6A9) DNA topoisomerase 2 OS=Agaricus bisporu...   789   0.0  
J3PRY3_PUCT1 (tr|J3PRY3) DNA topoisomerase 2 OS=Puccinia tritici...   788   0.0  
G7DZ82_MIXOS (tr|G7DZ82) DNA topoisomerase 2 OS=Mixia osmundae (...   788   0.0  
F4R8C9_MELLP (tr|F4R8C9) DNA topoisomerase 2 OS=Melampsora laric...   788   0.0  
R4X883_9ASCO (tr|R4X883) DNA topoisomerase 2 OS=Taphrina deforma...   787   0.0  
M9LUR2_9BASI (tr|M9LUR2) Uncharacterized protein OS=Pseudozyma a...   786   0.0  
F0VN61_NEOCL (tr|F0VN61) DNA topoisomerase 2 OS=Neospora caninum...   783   0.0  
F4NTP0_BATDJ (tr|F4NTP0) DNA topoisomerase 2 (Fragment) OS=Batra...   780   0.0  
M0VXE2_HORVD (tr|M0VXE2) DNA topoisomerase 2 OS=Hordeum vulgare ...   777   0.0  
L0P818_PNEJ8 (tr|L0P818) DNA topoisomerase 2 OS=Pneumocystis jir...   774   0.0  
M0VXE3_HORVD (tr|M0VXE3) Uncharacterized protein OS=Hordeum vulg...   773   0.0  
M1V3P5_CYAME (tr|M1V3P5) DNA topoisomerase 2 OS=Cyanidioschyzon ...   771   0.0  
M2Y981_GALSU (tr|M2Y981) DNA topoisomerase 2 OS=Galdieria sulphu...   771   0.0  
D8QKJ8_SCHCM (tr|D8QKJ8) DNA topoisomerase 2 OS=Schizophyllum co...   770   0.0  
B6K8S1_TOXGO (tr|B6K8S1) DNA topoisomerase 2 OS=Toxoplasma gondi...   769   0.0  
L8GML2_ACACA (tr|L8GML2) DNA topoisomerase 2 OS=Acanthamoeba cas...   769   0.0  
B9PK68_TOXGO (tr|B9PK68) DNA topoisomerase 2 OS=Toxoplasma gondi...   768   0.0  
E7A2Y1_SPORE (tr|E7A2Y1) DNA topoisomerase 2 OS=Sporisorium reil...   768   0.0  
B8C9P0_THAPS (tr|B8C9P0) DNA topoisomerase 2 (Fragment) OS=Thala...   763   0.0  
M5FVQ8_DACSP (tr|M5FVQ8) DNA topoisomerase II OS=Dacryopinax sp....   762   0.0  
K1VKL9_TRIAC (tr|K1VKL9) DNA topoisomerase 2 OS=Trichosporon asa...   762   0.0  
J5Q6D7_TRIAS (tr|J5Q6D7) DNA topoisomerase 2 OS=Trichosporon asa...   762   0.0  
B8C9L4_THAPS (tr|B8C9L4) DNA topoisomerase 2 OS=Thalassiosira ps...   761   0.0  
M5E815_MALSM (tr|M5E815) Genomic scaffold, msy_sf_6 OS=Malassezi...   760   0.0  
E5D8G5_9AGAR (tr|E5D8G5) DNA topoisomerase 2 OS=Omphalotus nidif...   758   0.0  
D7G0Y6_ECTSI (tr|D7G0Y6) DNA topoisomerase 2 OS=Ectocarpus silic...   758   0.0  
A8PTE9_MALGO (tr|A8PTE9) DNA topoisomerase 2 OS=Malassezia globo...   757   0.0  
R9AGH6_WALIC (tr|R9AGH6) DNA topoisomerase 2 OS=Wallemia ichthyo...   756   0.0  
D0N9W9_PHYIT (tr|D0N9W9) DNA topoisomerase 2 OS=Phytophthora inf...   754   0.0  
E0S6I5_ENCIT (tr|E0S6I5) DNA topoisomerase 2 OS=Encephalitozoon ...   753   0.0  
D2UZM0_NAEGR (tr|D2UZM0) DNA topoisomerase 2 OS=Naegleria gruber...   753   0.0  
F8PB32_SERL9 (tr|F8PB32) DNA topoisomerase 2 OS=Serpula lacryman...   751   0.0  
G4TR37_PIRID (tr|G4TR37) DNA topoisomerase 2 OS=Piriformospora i...   750   0.0  
Q8SS63_ENCCU (tr|Q8SS63) DNA topoisomerase 2 OS=Encephalitozoon ...   748   0.0  
M1KJ03_ENCCN (tr|M1KJ03) DNA topoisomerase 2 OS=Encephalitozoon ...   748   0.0  
Q7RJ69_PLAYO (tr|Q7RJ69) DNA topoisomerase 2 OS=Plasmodium yoeli...   748   0.0  
G7I3Z5_MEDTR (tr|G7I3Z5) DNA topoisomerase 2 OS=Medicago truncat...   748   0.0  
I6UKY3_ENCHA (tr|I6UKY3) DNA topoisomerase 2 OS=Encephalitozoon ...   748   0.0  
I3ESC1_NEMP1 (tr|I3ESC1) DNA topoisomerase 2 OS=Nematocida paris...   741   0.0  
I3EH32_NEMP3 (tr|I3EH32) DNA topoisomerase 2 OS=Nematocida paris...   741   0.0  
H6BPZ5_EXODN (tr|H6BPZ5) DNA topoisomerase 2 OS=Exophiala dermat...   740   0.0  
I4YK24_WALSC (tr|I4YK24) DNA topoisomerase 2 OS=Wallemia sebi (s...   740   0.0  
D0NA12_PHYIT (tr|D0NA12) DNA topoisomerase 2 OS=Phytophthora inf...   739   0.0  
K6UXA3_9APIC (tr|K6UXA3) DNA topoisomerase 2 OS=Plasmodium cynom...   738   0.0  
B6QAM9_PENMQ (tr|B6QAM9) DNA topoisomerase 2 OS=Penicillium marn...   738   0.0  
B7XIW3_ENTBH (tr|B7XIW3) DNA topoisomerase 2 OS=Enterocytozoon b...   737   0.0  
A1CUL0_ASPCL (tr|A1CUL0) DNA topoisomerase 2 OS=Aspergillus clav...   735   0.0  
Q8X1U4_ASPNG (tr|Q8X1U4) DNA topoisomerase 2 (Fragment) OS=Asper...   735   0.0  
Q8ILC8_PLAF7 (tr|Q8ILC8) DNA topoisomerase 2 OS=Plasmodium falci...   734   0.0  
G3YF10_ASPNA (tr|G3YF10) DNA topoisomerase 2 OS=Aspergillus nige...   734   0.0  
A5AB02_ASPNC (tr|A5AB02) DNA topoisomerase 2 OS=Aspergillus nige...   734   0.0  
A7ANB1_BABBO (tr|A7ANB1) DNA topoisomerase 2 OS=Babesia bovis GN...   734   0.0  
C5KAQ6_PERM5 (tr|C5KAQ6) DNA topoisomerase 2 OS=Perkinsus marinu...   734   0.0  
I7ADX3_ENCRO (tr|I7ADX3) DNA topoisomerase 2 OS=Encephalitozoon ...   734   0.0  
Q7Z2D0_PLAFA (tr|Q7Z2D0) DNA topoisomerase 2 OS=Plasmodium falci...   734   0.0  
J9VEP2_CRYNH (tr|J9VEP2) DNA topoisomerase 2 OS=Cryptococcus neo...   733   0.0  
F2PYI8_TRIEC (tr|F2PYI8) DNA topoisomerase 2 OS=Trichophyton equ...   733   0.0  
Q8X1U1_PENMA (tr|Q8X1U1) DNA topoisomerase 2 (Fragment) OS=Penic...   733   0.0  
F2SCP4_TRIRC (tr|F2SCP4) DNA topoisomerase 2 OS=Trichophyton rub...   733   0.0  
G7X785_ASPKW (tr|G7X785) DNA topoisomerase 2 OS=Aspergillus kawa...   732   0.0  
F0Y200_AURAN (tr|F0Y200) DNA topoisomerase 2 (Fragment) OS=Aureo...   732   0.0  
L2GVJ4_VAVCU (tr|L2GVJ4) DNA topoisomerase 2 OS=Vavraia culicis ...   732   0.0  
B6K4K4_SCHJY (tr|B6K4K4) DNA topoisomerase 2 OS=Schizosaccharomy...   732   0.0  
B8M038_TALSN (tr|B8M038) DNA topoisomerase 2 OS=Talaromyces stip...   731   0.0  
Q6PUA3_TETTH (tr|Q6PUA3) DNA topoisomerase 2 OS=Tetrahymena ther...   731   0.0  
I7MA91_TETTS (tr|I7MA91) DNA topoisomerase 2 OS=Tetrahymena ther...   731   0.0  
F2S2F0_TRIT1 (tr|F2S2F0) DNA topoisomerase 2 OS=Trichophyton ton...   730   0.0  
B3LBF9_PLAKH (tr|B3LBF9) DNA topoisomerase 2 OS=Plasmodium knowl...   729   0.0  
Q0CSB2_ASPTN (tr|Q0CSB2) DNA topoisomerase 2 OS=Aspergillus terr...   729   0.0  
D4DAV0_TRIVH (tr|D4DAV0) DNA topoisomerase 2 OS=Trichophyton ver...   729   0.0  
H3HSC7_STRPU (tr|H3HSC7) DNA topoisomerase 2 OS=Strongylocentrot...   729   0.0  
C5FWK9_ARTOC (tr|C5FWK9) DNA topoisomerase 2 OS=Arthroderma otae...   729   0.0  
Q8J2R9_TRIVO (tr|Q8J2R9) DNA topoisomerase 2 (Fragment) OS=Trich...   728   0.0  
Q8X1U0_TALFL (tr|Q8X1U0) DNA topoisomerase 2 (Fragment) OS=Talar...   728   0.0  
R7QHX8_CHOCR (tr|R7QHX8) Stackhouse genomic scaffold, scaffold_4...   728   0.0  
A1DP90_NEOFI (tr|A1DP90) DNA topoisomerase 2 OS=Neosartorya fisc...   728   0.0  
Q76C39_9EURO (tr|Q76C39) DNA topoisomerase 2 (Fragment) OS=Arthr...   728   0.0  
E3X4B6_ANODA (tr|E3X4B6) DNA topoisomerase 2 OS=Anopheles darlin...   727   0.0  
G0QS48_ICHMG (tr|G0QS48) DNA topoisomerase 2 OS=Ichthyophthirius...   727   0.0  
B7G2L6_PHATC (tr|B7G2L6) DNA topoisomerase 2 (Fragment) OS=Phaeo...   727   0.0  
Q8J2S0_9EURO (tr|Q8J2S0) DNA topoisomerase 2 (Fragment) OS=Trich...   726   0.0  
Q8J2S1_TRIRU (tr|Q8J2S1) DNA topoisomerase 2 (Fragment) OS=Trich...   726   0.0  
D4AZ93_ARTBC (tr|D4AZ93) DNA topoisomerase 2 OS=Arthroderma benh...   726   0.0  
D8MBJ7_BLAHO (tr|D8MBJ7) DNA topoisomerase 2 OS=Blastocystis hom...   726   0.0  
Q76C38_9EURO (tr|Q76C38) DNA topoisomerase 2 (Fragment) OS=Trich...   726   0.0  
E4US63_ARTGP (tr|E4US63) DNA topoisomerase 2 OS=Arthroderma gyps...   726   0.0  
J9HZI4_9SPIT (tr|J9HZI4) DNA topoisomerase 2 OS=Oxytricha trifal...   725   0.0  
Q76C43_9EURO (tr|Q76C43) DNA topoisomerase 2 (Fragment) OS=Arthr...   725   0.0  
L7JVE8_TRAHO (tr|L7JVE8) DNA topoisomerase 2 (Fragment) OS=Trach...   725   0.0  
Q76C37_9EURO (tr|Q76C37) DNA topoisomerase 2 (Fragment) OS=Trich...   724   0.0  
Q76C33_TRIVC (tr|Q76C33) DNA topoisomerase 2 (Fragment) OS=Trich...   723   0.0  
C6H7L1_AJECH (tr|C6H7L1) DNA topoisomerase 2 OS=Ajellomyces caps...   723   0.0  
Q4WLF7_ASPFU (tr|Q4WLF7) DNA topoisomerase 2 OS=Neosartorya fumi...   723   0.0  
B0XM58_ASPFC (tr|B0XM58) DNA topoisomerase 2 OS=Neosartorya fumi...   723   0.0  
C0NX13_AJECG (tr|C0NX13) DNA topoisomerase 2 OS=Ajellomyces caps...   723   0.0  
A6RG78_AJECN (tr|A6RG78) DNA topoisomerase 2 OS=Ajellomyces caps...   723   0.0  
A5K0R4_PLAVS (tr|A5K0R4) DNA topoisomerase 2 OS=Plasmodium vivax...   723   0.0  
Q76C35_9EURO (tr|Q76C35) DNA topoisomerase 2 (Fragment) OS=Arthr...   723   0.0  
Q76C34_TRITO (tr|Q76C34) DNA topoisomerase 2 (Fragment) OS=Trich...   723   0.0  
F0UWA9_AJEC8 (tr|F0UWA9) DNA topoisomerase 2 OS=Ajellomyces caps...   723   0.0  
J3KAE2_COCIM (tr|J3KAE2) DNA topoisomerase 2 OS=Coccidioides imm...   723   0.0  
Q8X1U5_ASPFM (tr|Q8X1U5) DNA topoisomerase 2 (Fragment) OS=Neosa...   723   0.0  
Q76C31_ARTBE (tr|Q76C31) DNA topoisomerase 2 (Fragment) OS=Arthr...   722   0.0  
Q76C32_ARTBE (tr|Q76C32) DNA topoisomerase 2 (Fragment) OS=Arthr...   722   0.0  
Q8J2R8_ARTOT (tr|Q8J2R8) DNA topoisomerase 2 (Fragment) OS=Arthr...   721   0.0  
F2QWR7_PICP7 (tr|F2QWR7) DNA topoisomerase 2 OS=Komagataella pas...   721   0.0  
E7R9F3_PICAD (tr|E7R9F3) DNA topoisomerase 2 OS=Pichia angusta (...   721   0.0  
Q76C30_ARTBE (tr|Q76C30) DNA topoisomerase 2 (Fragment) OS=Arthr...   721   0.0  
I8I908_ASPO3 (tr|I8I908) DNA topoisomerase 2 OS=Aspergillus oryz...   720   0.0  
C5P1Z4_COCP7 (tr|C5P1Z4) DNA topoisomerase 2 OS=Coccidioides pos...   720   0.0  
E9DFV8_COCPS (tr|E9DFV8) DNA topoisomerase 2 OS=Coccidioides pos...   720   0.0  
C0SGV5_PARBP (tr|C0SGV5) DNA topoisomerase 2 OS=Paracoccidioides...   720   0.0  
Q8J2R6_EPIFL (tr|Q8J2R6) DNA topoisomerase 2 (Fragment) OS=Epide...   719   0.0  
Q5CQG8_CRYPI (tr|Q5CQG8) DNA topoisomerase 2 OS=Cryptosporidium ...   719   0.0  
I7M5X3_TETTS (tr|I7M5X3) DNA topoisomerase 2 OS=Tetrahymena ther...   719   0.0  
Q8J2R7_ARTGY (tr|Q8J2R7) DNA topoisomerase 2 (Fragment) OS=Arthr...   719   0.0  
Q76C41_ARTGY (tr|Q76C41) DNA topoisomerase 2 (Fragment) OS=Arthr...   718   0.0  
Q2TY87_ASPOR (tr|Q2TY87) DNA topoisomerase 2 OS=Aspergillus oryz...   718   0.0  
Q8X1U6_ASPFL (tr|Q8X1U6) DNA topoisomerase 2 (Fragment) OS=Asper...   718   0.0  
Q4Z0B9_PLABA (tr|Q4Z0B9) DNA topoisomerase 2 (Fragment) OS=Plasm...   717   0.0  
H8ZD93_NEMS1 (tr|H8ZD93) DNA topoisomerase 2 OS=Nematocida sp. 1...   717   0.0  
R1C6H3_EMIHU (tr|R1C6H3) Putative DNA topoisomerase II OS=Emilia...   717   0.0  
Q76C42_9EURO (tr|Q76C42) DNA topoisomerase 2 (Fragment) OS=Arthr...   717   0.0  
J9IBE1_9SPIT (tr|J9IBE1) DNA topoisomerase 2 OS=Oxytricha trifal...   716   0.0  
B8NXR4_ASPFN (tr|B8NXR4) DNA topoisomerase 2 OS=Aspergillus flav...   716   0.0  
G3B4R2_CANTC (tr|G3B4R2) DNA topoisomerase 2 OS=Candida tenuis (...   716   0.0  
Q8X1U3_PENCH (tr|Q8X1U3) DNA topoisomerase 2 (Fragment) OS=Penic...   716   0.0  
H3A5L5_LATCH (tr|H3A5L5) DNA topoisomerase 2 OS=Latimeria chalum...   715   0.0  
R1ENP0_EMIHU (tr|R1ENP0) Uncharacterized protein OS=Emiliania hu...   715   0.0  
J9K4Y7_ACYPI (tr|J9K4Y7) DNA topoisomerase 2 OS=Acyrthosiphon pi...   714   0.0  
Q8X1U2_PENCI (tr|Q8X1U2) DNA topoisomerase 2 (Fragment) OS=Penic...   714   0.0  
Q76C40_9EURO (tr|Q76C40) DNA topoisomerase 2 (Fragment) OS=Arthr...   713   0.0  
B6HPI3_PENCW (tr|B6HPI3) DNA topoisomerase 2 OS=Penicillium chry...   713   0.0  
H0YZ82_TAEGU (tr|H0YZ82) DNA topoisomerase 2 OS=Taeniopygia gutt...   712   0.0  
H3A5L4_LATCH (tr|H3A5L4) DNA topoisomerase 2 (Fragment) OS=Latim...   712   0.0  
Q8X1U7_9EURO (tr|Q8X1U7) DNA topoisomerase 2 (Fragment) OS=Asper...   712   0.0  
E1BZ19_CHICK (tr|E1BZ19) DNA topoisomerase 2 OS=Gallus gallus GN...   711   0.0  
K9FXX9_PEND1 (tr|K9FXX9) DNA topoisomerase 2 OS=Penicillium digi...   711   0.0  
K9FFX4_PEND2 (tr|K9FFX4) DNA topoisomerase 2 OS=Penicillium digi...   711   0.0  
G8BRR7_TETPH (tr|G8BRR7) DNA topoisomerase 2 OS=Tetrapisispora p...   711   0.0  
D3B7U7_POLPA (tr|D3B7U7) DNA topoisomerase 2 OS=Polysphondylium ...   711   0.0  
R0JC34_ANAPL (tr|R0JC34) DNA topoisomerase 2-beta (Fragment) OS=...   711   0.0  
K0KT01_WICCF (tr|K0KT01) DNA topoisomerase 2 OS=Wickerhamomyces ...   711   0.0  
G8YUD2_PICSO (tr|G8YUD2) DNA topoisomerase 2 OS=Pichia sorbitoph...   711   0.0  
H2QM73_PANTR (tr|H2QM73) DNA topoisomerase 2 OS=Pan troglodytes ...   709   0.0  
H9F8L1_MACMU (tr|H9F8L1) DNA topoisomerase 2 (Fragment) OS=Macac...   709   0.0  
L8WTI6_9HOMO (tr|L8WTI6) DNA topoisomerase 2 OS=Rhizoctonia sola...   709   0.0  
G8BHF5_CANPC (tr|G8BHF5) DNA topoisomerase 2 OS=Candida parapsil...   709   0.0  
G1XKF5_ARTOA (tr|G1XKF5) DNA topoisomerase 2 OS=Arthrobotrys oli...   709   0.0  
F7E5A9_MACMU (tr|F7E5A9) DNA topoisomerase 2 OS=Macaca mulatta G...   709   0.0  
K7CLW1_PANTR (tr|K7CLW1) DNA topoisomerase 2 OS=Pan troglodytes ...   709   0.0  
I2CT72_MACMU (tr|I2CT72) DNA topoisomerase 2 OS=Macaca mulatta G...   709   0.0  
G3SGP2_GORGO (tr|G3SGP2) DNA topoisomerase 2 OS=Gorilla gorilla ...   709   0.0  
K0TQD1_THAOC (tr|K0TQD1) DNA topoisomerase 2 OS=Thalassiosira oc...   709   0.0  
G1QUD9_NOMLE (tr|G1QUD9) DNA topoisomerase 2 OS=Nomascus leucoge...   708   0.0  
H2PBB5_PONAB (tr|H2PBB5) DNA topoisomerase 2 OS=Pongo abelii GN=...   708   0.0  
Q7PWM2_ANOGA (tr|Q7PWM2) DNA topoisomerase 2 (Fragment) OS=Anoph...   708   0.0  
Q71UH4_HUMAN (tr|Q71UH4) DNA topoisomerase 2 (Fragment) OS=Homo ...   708   0.0  
H8WZH4_CANO9 (tr|H8WZH4) DNA topoisomerase 2 OS=Candida orthopsi...   708   0.0  
F1KQU1_ASCSU (tr|F1KQU1) DNA topoisomerase 2 OS=Ascaris suum PE=...   708   0.0  
G7NY94_MACFA (tr|G7NY94) DNA topoisomerase 2 (Fragment) OS=Macac...   708   0.0  
F1KQV5_ASCSU (tr|F1KQV5) DNA topoisomerase 2 OS=Ascaris suum PE=...   707   0.0  
L7MAX8_9ACAR (tr|L7MAX8) DNA topoisomerase 2 (Fragment) OS=Rhipi...   707   0.0  
Q76C44_9EURO (tr|Q76C44) DNA topoisomerase 2 (Fragment) OS=Arthr...   707   0.0  
H2UY96_TAKRU (tr|H2UY96) DNA topoisomerase 2 (Fragment) OS=Takif...   707   0.0  
F7FGH6_ORNAN (tr|F7FGH6) DNA topoisomerase 2 OS=Ornithorhynchus ...   707   0.0  
H2UY95_TAKRU (tr|H2UY95) DNA topoisomerase 2 (Fragment) OS=Takif...   707   0.0  
G3I5N5_CRIGR (tr|G3I5N5) DNA topoisomerase 2 OS=Cricetulus grise...   706   0.0  
L8IH03_BOSMU (tr|L8IH03) DNA topoisomerase 2 (Fragment) OS=Bos g...   706   0.0  
K9IVG7_DESRO (tr|K9IVG7) DNA topoisomerase 2 (Fragment) OS=Desmo...   706   0.0  
K9IV03_DESRO (tr|K9IV03) DNA topoisomerase 2 (Fragment) OS=Desmo...   706   0.0  
I2H4V9_TETBL (tr|I2H4V9) DNA topoisomerase 2 OS=Tetrapisispora b...   706   0.0  
L5MEK8_MYODS (tr|L5MEK8) DNA topoisomerase 2 (Fragment) OS=Myoti...   706   0.0  
F2T3U6_AJEDA (tr|F2T3U6) DNA topoisomerase 2 OS=Ajellomyces derm...   706   0.0  
K9IVY4_DESRO (tr|K9IVY4) DNA topoisomerase 2 (Fragment) OS=Desmo...   706   0.0  
B4DKD0_HUMAN (tr|B4DKD0) DNA topoisomerase 2 (Fragment) OS=Homo ...   706   0.0  
E9PCY5_HUMAN (tr|E9PCY5) DNA topoisomerase 2 (Fragment) OS=Homo ...   706   0.0  
G9KUN4_MUSPF (tr|G9KUN4) DNA topoisomerase 2 (Fragment) OS=Muste...   706   0.0  
Q8J2S7_9EURO (tr|Q8J2S7) DNA topoisomerase 2 (Fragment) OS=Asper...   706   0.0  
G1NW71_MYOLU (tr|G1NW71) DNA topoisomerase 2 (Fragment) OS=Myoti...   706   0.0  
I1C6D9_RHIO9 (tr|I1C6D9) DNA topoisomerase 2 OS=Rhizopus delemar...   706   0.0  
H0WKM4_OTOGA (tr|H0WKM4) DNA topoisomerase 2 (Fragment) OS=Otole...   706   0.0  
H2UY97_TAKRU (tr|H2UY97) DNA topoisomerase 2 (Fragment) OS=Takif...   705   0.0  
G0R0E4_ICHMG (tr|G0R0E4) Putative uncharacterized protein OS=Ich...   705   0.0  
Q7LMA0_YEASX (tr|Q7LMA0) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
N1NXH6_YEASX (tr|N1NXH6) Top2p OS=Saccharomyces cerevisiae CEN.P...   705   0.0  
A6ZRZ2_YEAS7 (tr|A6ZRZ2) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
C8ZGE3_YEAS8 (tr|C8ZGE3) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
E9P8H8_YEASX (tr|E9P8H8) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
E9P8H4_YEASX (tr|E9P8H4) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
B3LNU7_YEAS1 (tr|B3LNU7) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
E9P8H5_YEASX (tr|E9P8H5) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
R0L0H5_ANAPL (tr|R0L0H5) DNA topoisomerase 2-alpha (Fragment) OS...   705   0.0  
E9B049_LEIMU (tr|E9B049) DNA topoisomerase 2 OS=Leishmania mexic...   705   0.0  
E9P8H7_YEASX (tr|E9P8H7) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
G2WM16_YEASK (tr|G2WM16) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
E9P8G9_YEASX (tr|E9P8G9) DNA topoisomerase 2 OS=Saccharomyces ce...   705   0.0  
F1MU48_BOVIN (tr|F1MU48) DNA topoisomerase 2 (Fragment) OS=Bos t...   705   0.0  
M3X192_FELCA (tr|M3X192) DNA topoisomerase 2 OS=Felis catus GN=T...   705   0.0  
F1Q8Y8_DANRE (tr|F1Q8Y8) DNA topoisomerase 2 OS=Danio rerio GN=t...   704   0.0  
F6S771_CALJA (tr|F6S771) DNA topoisomerase 2 OS=Callithrix jacch...   704   0.0  
C5GEX1_AJEDR (tr|C5GEX1) DNA topoisomerase 2 OS=Ajellomyces derm...   704   0.0  
L8ISS2_BOSMU (tr|L8ISS2) DNA topoisomerase 2 (Fragment) OS=Bos g...   704   0.0  
Q1LUT2_DANRE (tr|Q1LUT2) Uncharacterized protein OS=Danio rerio ...   704   0.0  
E9BJW5_LEIDB (tr|E9BJW5) DNA topoisomerase 2 OS=Leishmania donov...   704   0.0  
D2HUZ8_AILME (tr|D2HUZ8) DNA topoisomerase 2 (Fragment) OS=Ailur...   704   0.0  
H2QCW5_PANTR (tr|H2QCW5) DNA topoisomerase 2 (Fragment) OS=Pan t...   704   0.0  
G0WCR2_NAUDC (tr|G0WCR2) DNA topoisomerase 2 OS=Naumovozyma dair...   704   0.0  
L5L3V1_PTEAL (tr|L5L3V1) DNA topoisomerase 2 OS=Pteropus alecto ...   704   0.0  
H0V8L7_CAVPO (tr|H0V8L7) DNA topoisomerase 2 OS=Cavia porcellus ...   704   0.0  
G8YSX5_PICSO (tr|G8YSX5) DNA topoisomerase 2 OS=Pichia sorbitoph...   704   0.0  
Q4Q836_LEIMA (tr|Q4Q836) DNA topoisomerase 2 OS=Leishmania major...   704   0.0  
E9P8H2_YEASX (tr|E9P8H2) DNA topoisomerase 2 OS=Saccharomyces ce...   704   0.0  
E9P8H0_YEASX (tr|E9P8H0) DNA topoisomerase 2 OS=Saccharomyces ce...   704   0.0  
C7GUN8_YEAS2 (tr|C7GUN8) DNA topoisomerase 2 OS=Saccharomyces ce...   704   0.0  
H2LHR6_ORYLA (tr|H2LHR6) DNA topoisomerase 2 (Fragment) OS=Oryzi...   704   0.0  
F7CL38_HORSE (tr|F7CL38) DNA topoisomerase 2 (Fragment) OS=Equus...   704   0.0  
Q6CTC1_KLULA (tr|Q6CTC1) DNA topoisomerase 2 OS=Kluyveromyces la...   704   0.0  
O55078_CRILO (tr|O55078) DNA topoisomerase 2 OS=Cricetulus longi...   704   0.0  
M3YL11_MUSPF (tr|M3YL11) DNA topoisomerase 2 OS=Mustela putorius...   704   0.0  
G5BF97_HETGA (tr|G5BF97) DNA topoisomerase 2 OS=Heterocephalus g...   704   0.0  
C5K1W3_AJEDS (tr|C5K1W3) DNA topoisomerase 2 OS=Ajellomyces derm...   704   0.0  
K7FJR3_PELSI (tr|K7FJR3) DNA topoisomerase 2 OS=Pelodiscus sinen...   704   0.0  
F1MDU7_BOVIN (tr|F1MDU7) DNA topoisomerase 2 OS=Bos taurus GN=TO...   703   0.0  
F6T9B4_CALJA (tr|F6T9B4) DNA topoisomerase 2 OS=Callithrix jacch...   703   0.0  
H0VTB2_CAVPO (tr|H0VTB2) DNA topoisomerase 2 (Fragment) OS=Cavia...   703   0.0  
G5AX78_HETGA (tr|G5AX78) DNA topoisomerase 2 (Fragment) OS=Heter...   703   0.0  
O55079_CRILO (tr|O55079) DNA topoisomerase 2 OS=Cricetulus longi...   703   0.0  
M7AX24_CHEMY (tr|M7AX24) DNA topoisomerase 2-beta (Fragment) OS=...   703   0.0  
H9GEY4_ANOCA (tr|H9GEY4) DNA topoisomerase 2 OS=Anolis carolinen...   703   0.0  
G3WB20_SARHA (tr|G3WB20) DNA topoisomerase 2 (Fragment) OS=Sarco...   703   0.0  
G9KUN2_MUSPF (tr|G9KUN2) Topoisomerase II alpha 170kDa (Fragment...   703   0.0  
F7BGW3_XENTR (tr|F7BGW3) DNA topoisomerase 2 OS=Xenopus tropical...   703   0.0  
G0VIC6_NAUCC (tr|G0VIC6) DNA topoisomerase 2 OS=Naumovozyma cast...   703   0.0  
F7ABY1_MONDO (tr|F7ABY1) DNA topoisomerase 2 OS=Monodelphis dome...   703   0.0  
F4PXP4_DICFS (tr|F4PXP4) DNA topoisomerase 2 OS=Dictyostelium fa...   703   0.0  
G3UIA0_LOXAF (tr|G3UIA0) DNA topoisomerase 2 OS=Loxodonta africa...   703   0.0  
G3RAE1_GORGO (tr|G3RAE1) DNA topoisomerase 2 OS=Gorilla gorilla ...   702   0.0  
G3T1I5_LOXAF (tr|G3T1I5) DNA topoisomerase 2 (Fragment) OS=Loxod...   702   0.0  
A4I3V9_LEIIN (tr|A4I3V9) DNA topoisomerase 2 (Fragment) OS=Leish...   702   0.0  
Q6PUA4_TETTH (tr|Q6PUA4) DNA topoisomerase 2 OS=Tetrahymena ther...   702   0.0  
A3GF24_PICST (tr|A3GF24) DNA topoisomerase 2 OS=Scheffersomyces ...   702   0.0  
B7P0P1_IXOSC (tr|B7P0P1) DNA topoisomerase 2 OS=Ixodes scapulari...   702   0.0  
H2LXG9_ORYLA (tr|H2LXG9) DNA topoisomerase 2 (Fragment) OS=Oryzi...   702   0.0  
G1LN78_AILME (tr|G1LN78) DNA topoisomerase 2 OS=Ailuropoda melan...   702   0.0  
G1SIE2_RABIT (tr|G1SIE2) DNA topoisomerase 2 OS=Oryctolagus cuni...   702   0.0  
Q5REX2_PONAB (tr|Q5REX2) DNA topoisomerase 2 OS=Pongo abelii GN=...   702   0.0  
F7D0D3_MONDO (tr|F7D0D3) DNA topoisomerase 2 OS=Monodelphis dome...   701   0.0  
H2UY94_TAKRU (tr|H2UY94) DNA topoisomerase 2 OS=Takifugu rubripe...   701   0.0  
G3WFK3_SARHA (tr|G3WFK3) DNA topoisomerase 2 OS=Sarcophilus harr...   701   0.0  
E0VS84_PEDHC (tr|E0VS84) DNA topoisomerase 2 OS=Pediculus humanu...   701   0.0  
K7BYJ3_PANTR (tr|K7BYJ3) DNA topoisomerase 2 OS=Pan troglodytes ...   701   0.0  
A4HGT2_LEIBR (tr|A4HGT2) DNA topoisomerase 2 OS=Leishmania brazi...   701   0.0  
E9HGV5_DAPPU (tr|E9HGV5) DNA topoisomerase 2 OS=Daphnia pulex GN...   701   0.0  
A8Q990_BRUMA (tr|A8Q990) DNA topoisomerase 2 OS=Brugia malayi GN...   701   0.0  
L9JX05_TUPCH (tr|L9JX05) DNA topoisomerase 2 OS=Tupaia chinensis...   701   0.0  
H2NU77_PONAB (tr|H2NU77) DNA topoisomerase 2 (Fragment) OS=Pongo...   701   0.0  
F1M7A0_RAT (tr|F1M7A0) DNA topoisomerase 2 (Fragment) OS=Rattus ...   701   0.0  
M3HI84_CANMA (tr|M3HI84) DNA topoisomerase 2 OS=Candida maltosa ...   701   0.0  
Q14TE9_RAT (tr|Q14TE9) DNA topoisomerase 2 OS=Rattus norvegicus ...   701   0.0  
G3AEF9_SPAPN (tr|G3AEF9) DNA topoisomerase 2 OS=Spathaspora pass...   701   0.0  
G1L1L3_AILME (tr|G1L1L3) DNA topoisomerase 2 (Fragment) OS=Ailur...   700   0.0  
I3KVE9_ORENI (tr|I3KVE9) DNA topoisomerase 2 OS=Oreochromis nilo...   700   0.0  
I3KVE8_ORENI (tr|I3KVE8) DNA topoisomerase 2 OS=Oreochromis nilo...   700   0.0  
L5JRH2_PTEAL (tr|L5JRH2) DNA topoisomerase 2 OS=Pteropus alecto ...   700   0.0  
G1SDX3_RABIT (tr|G1SDX3) DNA topoisomerase 2 (Fragment) OS=Oryct...   700   0.0  
J4C854_THEOR (tr|J4C854) DNA topoisomerase 2 OS=Theileria orient...   700   0.0  
H3C592_TETNG (tr|H3C592) DNA topoisomerase 2 (Fragment) OS=Tetra...   700   0.0  
F1PRA7_CANFA (tr|F1PRA7) DNA topoisomerase 2 (Fragment) OS=Canis...   700   0.0  
C5DMF0_LACTC (tr|C5DMF0) DNA topoisomerase 2 OS=Lachancea thermo...   700   0.0  
G1PAB1_MYOLU (tr|G1PAB1) DNA topoisomerase 2 OS=Myotis lucifugus...   700   0.0  
Q6C7Z9_YARLI (tr|Q6C7Z9) DNA topoisomerase 2 OS=Yarrowia lipolyt...   700   0.0  
K7F361_PELSI (tr|K7F361) DNA topoisomerase 2 OS=Pelodiscus sinen...   699   0.0  
C5MDS2_CANTT (tr|C5MDS2) DNA topoisomerase 2 OS=Candida tropical...   699   0.0  
H3D5N4_TETNG (tr|H3D5N4) DNA topoisomerase 2 (Fragment) OS=Tetra...   699   0.0  
G3NZ45_GASAC (tr|G3NZ45) DNA topoisomerase 2 OS=Gasterosteus acu...   699   0.0  
A5E7X7_LODEL (tr|A5E7X7) DNA topoisomerase 2 OS=Lodderomyces elo...   699   0.0  
J9PAY8_CANFA (tr|J9PAY8) DNA topoisomerase 2 OS=Canis familiaris...   699   0.0  
B4KIH0_DROMO (tr|B4KIH0) DNA topoisomerase 2 OS=Drosophila mojav...   699   0.0  
F6S0Y0_CALJA (tr|F6S0Y0) DNA topoisomerase 2 OS=Callithrix jacch...   699   0.0  
G3P0Y7_GASAC (tr|G3P0Y7) DNA topoisomerase 2 (Fragment) OS=Gaste...   699   0.0  
F1RS45_PIG (tr|F1RS45) DNA topoisomerase 2 OS=Sus scrofa PE=2 SV=2    699   0.0  
G1NAT9_MELGA (tr|G1NAT9) DNA topoisomerase 2 (Fragment) OS=Melea...   699   0.0  
G3UST0_MELGA (tr|G3UST0) DNA topoisomerase 2 (Fragment) OS=Melea...   699   0.0  
A0C7Z3_PARTE (tr|A0C7Z3) DNA topoisomerase 2 OS=Paramecium tetra...   698   0.0  
I3NGU9_SPETR (tr|I3NGU9) DNA topoisomerase 2 OS=Spermophilus tri...   698   0.0  
I3M4Z3_SPETR (tr|I3M4Z3) DNA topoisomerase 2 OS=Spermophilus tri...   698   0.0  
B3RRE6_TRIAD (tr|B3RRE6) DNA topoisomerase 2 (Fragment) OS=Trich...   697   0.0  
G3UST4_MELGA (tr|G3UST4) DNA topoisomerase 2 (Fragment) OS=Melea...   697   0.0  
H9JQ10_BOMMO (tr|H9JQ10) DNA topoisomerase 2 OS=Bombyx mori GN=T...   697   0.0  
G5E707_LOXAF (tr|G5E707) DNA topoisomerase 2 (Fragment) OS=Loxod...   697   0.0  
G6CLH9_DANPL (tr|G6CLH9) DNA topoisomerase 2 OS=Danaus plexippus...   697   0.0  
B6AEK2_CRYMR (tr|B6AEK2) DNA topoisomerase 2 OS=Cryptosporidium ...   697   0.0  
H2B0P0_KAZAF (tr|H2B0P0) DNA topoisomerase 2 OS=Kazachstania afr...   697   0.0  
K2RJJ1_MACPH (tr|K2RJJ1) DNA topoisomerase 2 OS=Macrophomina pha...   697   0.0  
M3WBT9_FELCA (tr|M3WBT9) DNA topoisomerase 2 OS=Felis catus GN=T...   697   0.0  
M7BE62_CHEMY (tr|M7BE62) DNA topoisomerase 2-alpha OS=Chelonia m...   697   0.0  
B9WF18_CANDC (tr|B9WF18) DNA topoisomerase 2 OS=Candida dublinie...   697   0.0  
F1Q2M4_CANFA (tr|F1Q2M4) DNA topoisomerase 2 OS=Canis familiaris...   696   0.0  
F7A8M1_ORNAN (tr|F7A8M1) DNA topoisomerase 2 OS=Ornithorhynchus ...   696   0.0  
B4GWX0_DROPE (tr|B4GWX0) DNA topoisomerase 2 OS=Drosophila persi...   696   0.0  
Q29K53_DROPS (tr|Q29K53) DNA topoisomerase 2 OS=Drosophila pseud...   696   0.0  
I3JVT3_ORENI (tr|I3JVT3) DNA topoisomerase 2 OS=Oreochromis nilo...   696   0.0  
Q5A1E7_CANAL (tr|Q5A1E7) DNA topoisomerase 2 OS=Candida albicans...   696   0.0  
G3S3V9_GORGO (tr|G3S3V9) DNA topoisomerase 2 OS=Gorilla gorilla ...   696   0.0  
F1NZF0_CHICK (tr|F1NZF0) DNA topoisomerase 2 OS=Gallus gallus GN...   696   0.0  
A0D9B8_PARTE (tr|A0D9B8) DNA topoisomerase 2 OS=Paramecium tetra...   696   0.0  
H0YVT8_TAEGU (tr|H0YVT8) DNA topoisomerase 2 OS=Taeniopygia gutt...   695   0.0  
Q6INT0_XENLA (tr|Q6INT0) DNA topoisomerase 2 OS=Xenopus laevis G...   695   0.0  
H3DLE0_TETNG (tr|H3DLE0) DNA topoisomerase 2 (Fragment) OS=Tetra...   695   0.0  
M4ARH2_XIPMA (tr|M4ARH2) DNA topoisomerase 2 OS=Xiphophorus macu...   694   0.0  
Q5PQY4_DANRE (tr|Q5PQY4) DNA topoisomerase 2 OS=Danio rerio GN=t...   694   0.0  
H2SY52_TAKRU (tr|H2SY52) DNA topoisomerase 2 (Fragment) OS=Takif...   694   0.0  
K1Q404_CRAGI (tr|K1Q404) DNA topoisomerase 2 OS=Crassostrea giga...   694   0.0  
M4AA94_XIPMA (tr|M4AA94) DNA topoisomerase 2 OS=Xiphophorus macu...   694   0.0  
G1KAM2_ANOCA (tr|G1KAM2) DNA topoisomerase 2 OS=Anolis carolinen...   694   0.0  
H2SY55_TAKRU (tr|H2SY55) DNA topoisomerase 2 (Fragment) OS=Takif...   694   0.0  
G0V250_TRYCI (tr|G0V250) DNA topoisomerase 2 OS=Trypanosoma cong...   694   0.0  
A0FCQ0_TRYCO (tr|A0FCQ0) DNA topoisomerase 2 OS=Trypanosoma cong...   694   0.0  
H2SY53_TAKRU (tr|H2SY53) DNA topoisomerase 2 OS=Takifugu rubripe...   693   0.0  
Q9DFB7_CHICK (tr|Q9DFB7) DNA topoisomerase 2 OS=Gallus gallus GN...   693   0.0  
B0WRP3_CULQU (tr|B0WRP3) DNA topoisomerase 2 OS=Culex quinquefas...   693   0.0  
J0DYM4_LOALO (tr|J0DYM4) DNA topoisomerase 2 OS=Loa loa GN=LOAG_...   693   0.0  
M2N8Z0_9PEZI (tr|M2N8Z0) DNA topoisomerase 2 OS=Baudoinia compni...   693   0.0  
J0XI42_LOALO (tr|J0XI42) DNA topoisomerase 2 OS=Loa loa GN=LOAG_...   692   0.0  
H2SY54_TAKRU (tr|H2SY54) DNA topoisomerase 2 (Fragment) OS=Takif...   692   0.0  
B4N154_DROWI (tr|B4N154) DNA topoisomerase 2 OS=Drosophila willi...   692   0.0  
B4M8I9_DROVI (tr|B4M8I9) DNA topoisomerase 2 OS=Drosophila viril...   692   0.0  
G0NR59_CAEBE (tr|G0NR59) DNA topoisomerase 2 OS=Caenorhabditis b...   692   0.0  
Q2PQ59_9TRYP (tr|Q2PQ59) DNA topoisomerase 2 OS=Trypanosoma bruc...   692   0.0  
D0A926_TRYB9 (tr|D0A926) DNA topoisomerase 2 OS=Trypanosoma bruc...   692   0.0  
Q7ZXS2_XENLA (tr|Q7ZXS2) DNA topoisomerase 2 (Fragment) OS=Xenop...   692   0.0  
F0ZNB2_DICPU (tr|F0ZNB2) DNA topoisomerase 2 (Fragment) OS=Dicty...   692   0.0  
Q383C4_TRYB2 (tr|Q383C4) DNA topoisomerase 2 OS=Trypanosoma bruc...   691   0.0  
E5SB63_TRISP (tr|E5SB63) DNA topoisomerase 2 OS=Trichinella spir...   691   0.0  
Q0IEA2_AEDAE (tr|Q0IEA2) DNA topoisomerase 2 (Fragment) OS=Aedes...   691   0.0  
Q6BQW4_DEBHA (tr|Q6BQW4) DNA topoisomerase 2 OS=Debaryomyces han...   691   0.0  
B4JCU9_DROGR (tr|B4JCU9) DNA topoisomerase 2 OS=Drosophila grims...   691   0.0  
R1E6Z3_9PEZI (tr|R1E6Z3) Putative dna topoisomerase ii protein O...   690   0.0  
Q2PQ58_9TRYP (tr|Q2PQ58) DNA topoisomerase 2 OS=Trypanosoma bruc...   690   0.0  
D0A927_TRYB9 (tr|D0A927) DNA topoisomerase 2 OS=Trypanosoma bruc...   690   0.0  
J6EDE8_SACK1 (tr|J6EDE8) DNA topoisomerase 2 OS=Saccharomyces ku...   690   0.0  
Q4Y8Y8_PLACH (tr|Q4Y8Y8) DNA topoisomerase II, putative (Fragmen...   690   0.0  
G8ZS14_TORDC (tr|G8ZS14) DNA topoisomerase 2 OS=Torulaspora delb...   690   0.0  
A7TEE2_VANPO (tr|A7TEE2) DNA topoisomerase 2 OS=Vanderwaltozyma ...   690   0.0  
B3MN65_DROAN (tr|B3MN65) DNA topoisomerase 2 OS=Drosophila anana...   690   0.0  
B4I5V4_DROSE (tr|B4I5V4) DNA topoisomerase 2 OS=Drosophila seche...   689   0.0  
L0AWF0_BABEQ (tr|L0AWF0) DNA topoisomerase 2 OS=Babesia equi GN=...   689   0.0  
J8PZX9_SACAR (tr|J8PZX9) DNA topoisomerase 2 OS=Saccharomyces ar...   689   0.0  
I7IP59_BABMI (tr|I7IP59) DNA topoisomerase 2 OS=Babesia microti ...   689   0.0  
B4PAY8_DROYA (tr|B4PAY8) DNA topoisomerase 2 OS=Drosophila yakub...   688   0.0  
L7FL49_ENTIV (tr|L7FL49) DNA topoisomerase 2 OS=Entamoeba invade...   687   0.0  
A0C0L0_PARTE (tr|A0C0L0) DNA topoisomerase 2 OS=Paramecium tetra...   687   0.0  
D5GF28_TUBMM (tr|D5GF28) DNA topoisomerase 2 OS=Tuber melanospor...   687   0.0  
B3NM53_DROER (tr|B3NM53) DNA topoisomerase 2 OS=Drosophila erect...   687   0.0  
M4BBA0_HYAAE (tr|M4BBA0) DNA topoisomerase 2 OS=Hyaloperonospora...   686   0.0  
M2TFF2_COCSA (tr|M2TFF2) DNA topoisomerase 2 OS=Bipolaris soroki...   686   0.0  
G0V251_TRYCI (tr|G0V251) DNA topoisomerase 2 OS=Trypanosoma cong...   686   0.0  
C4JNJ9_UNCRE (tr|C4JNJ9) DNA topoisomerase 2 OS=Uncinocarpus ree...   686   0.0  
M9PDQ1_DROME (tr|M9PDQ1) Topoisomerase 2, isoform B OS=Drosophil...   685   0.0  
E3LH66_CAERE (tr|E3LH66) DNA topoisomerase 2 OS=Caenorhabditis r...   685   0.0  
Q6NR40_DROME (tr|Q6NR40) DNA topoisomerase 2 OS=Drosophila melan...   684   0.0  
Q5B224_EMENI (tr|Q5B224) DNA topoisomerase 2 OS=Emericella nidul...   684   0.0  
O59864_EMEND (tr|O59864) DNA topoisomerase 2 OS=Emericella nidul...   684   0.0  
F7EVJ4_MACMU (tr|F7EVJ4) DNA topoisomerase 2 (Fragment) OS=Macac...   683   0.0  
M1HT83_9PHYC (tr|M1HT83) DNA topoisomerase II OS=Paramecium burs...   683   0.0  
N4XQ39_COCHE (tr|N4XQ39) Uncharacterized protein OS=Bipolaris ma...   683   0.0  
M2U432_COCHE (tr|M2U432) DNA topoisomerase 2 OS=Bipolaris maydis...   683   0.0  
K2PB88_TRYCR (tr|K2PB88) DNA topoisomerase 2 OS=Trypanosoma cruz...   683   0.0  
R0J4Z9_SETTU (tr|R0J4Z9) Uncharacterized protein OS=Setosphaeria...   682   0.0  
Q4DE53_TRYCC (tr|Q4DE53) DNA topoisomerase 2 OS=Trypanosoma cruz...   682   0.0  
C5DUB5_ZYGRC (tr|C5DUB5) DNA topoisomerase 2 OS=Zygosaccharomyce...   682   0.0  
B4Q9Y2_DROSI (tr|B4Q9Y2) DNA topoisomerase 2 OS=Drosophila simul...   682   0.0  
A8WTL4_CAEBR (tr|A8WTL4) DNA topoisomerase 2 OS=Caenorhabditis b...   682   0.0  
G1U773_RABIT (tr|G1U773) DNA topoisomerase 2 OS=Oryctolagus cuni...   682   0.0  
H9YVX9_MACMU (tr|H9YVX9) DNA topoisomerase 2 OS=Macaca mulatta G...   682   0.0  
Q4D8L4_TRYCC (tr|Q4D8L4) DNA topoisomerase 2 OS=Trypanosoma cruz...   681   0.0  
Q0UPF9_PHANO (tr|Q0UPF9) DNA topoisomerase 2 OS=Phaeosphaeria no...   681   0.0  
E3RS76_PYRTT (tr|E3RS76) DNA topoisomerase 2 OS=Pyrenophora tere...   681   0.0  
F7EVK2_MACMU (tr|F7EVK2) DNA topoisomerase 2 (Fragment) OS=Macac...   681   0.0  
B2VZ36_PYRTR (tr|B2VZ36) DNA topoisomerase 2 OS=Pyrenophora trit...   679   0.0  
N1PUU3_MYCPJ (tr|N1PUU3) Uncharacterized protein OS=Dothistroma ...   679   0.0  
K7INH7_NASVI (tr|K7INH7) DNA topoisomerase 2 OS=Nasonia vitripen...   679   0.0  
Q6DRC7_DANRE (tr|Q6DRC7) DNA topoisomerase 2 OS=Danio rerio GN=t...   679   0.0  
K4DSZ3_TRYCR (tr|K4DSZ3) DNA topoisomerase 2 OS=Trypanosoma cruz...   679   0.0  
M2S5G2_ENTHI (tr|M2S5G2) DNA topoisomerase 2 OS=Entamoeba histol...   679   0.0  
K2GUU9_ENTNP (tr|K2GUU9) DNA topoisomerase 2 OS=Entamoeba nuttal...   679   0.0  
Q6RCM0_ENTHI (tr|Q6RCM0) DNA topoisomerase 2 OS=Entamoeba histol...   679   0.0  
N9TMP0_ENTHI (tr|N9TMP0) DNA topoisomerase II, putative OS=Entam...   679   0.0  
M7WKV7_ENTHI (tr|M7WKV7) DNA topoisomerase II, putative OS=Entam...   679   0.0  
M3TVF1_ENTHI (tr|M3TVF1) DNA topoisomerase 2 OS=Entamoeba histol...   679   0.0  
B0EP10_ENTDS (tr|B0EP10) DNA topoisomerase 2 OS=Entamoeba dispar...   678   0.0  
H0WJ18_OTOGA (tr|H0WJ18) DNA topoisomerase 2 OS=Otolemur garnett...   678   0.0  
R7Z0Q9_9EURO (tr|R7Z0Q9) Uncharacterized protein OS=Coniosporium...   677   0.0  
J7RDX4_KAZNA (tr|J7RDX4) DNA topoisomerase 2 OS=Kazachstania nag...   677   0.0  
Q4S4N6_TETNG (tr|Q4S4N6) DNA topoisomerase 2 (Fragment) OS=Tetra...   676   0.0  
C1GGA2_PARBD (tr|C1GGA2) DNA topoisomerase 2 OS=Paracoccidioides...   676   0.0  
C1GXB2_PARBA (tr|C1GXB2) DNA topoisomerase 2 OS=Paracoccidioides...   676   0.0  
D6WF48_TRICA (tr|D6WF48) DNA topoisomerase 2 OS=Tribolium castan...   676   0.0  
G0S8N4_CHATD (tr|G0S8N4) DNA topoisomerase 2 OS=Chaetomium therm...   676   0.0  
J9EX29_WUCBA (tr|J9EX29) DNA topoisomerase 2 (Fragment) OS=Wuche...   676   0.0  
H2WBZ3_CAEJA (tr|H2WBZ3) DNA topoisomerase 2 OS=Caenorhabditis j...   675   0.0  
H8XX09_TRYRA (tr|H8XX09) DNA topoisomerase 2 OS=Trypanosoma rang...   674   0.0  
M1HX85_9PHYC (tr|M1HX85) DNA topoisomerase II OS=Paramecium burs...   674   0.0  
M1I0N6_9PHYC (tr|M1I0N6) DNA topoisomerase II OS=Acanthocystis t...   673   0.0  
F7VNQ7_SORMK (tr|F7VNQ7) DNA topoisomerase 2 OS=Sordaria macrosp...   672   0.0  
F1KQW6_ASCSU (tr|F1KQW6) DNA topoisomerase 2 OS=Ascaris suum PE=...   672   0.0  
F1KQW9_ASCSU (tr|F1KQW9) DNA topoisomerase 2 OS=Ascaris suum PE=...   672   0.0  
F9FE83_FUSOF (tr|F9FE83) DNA topoisomerase 2 OS=Fusarium oxyspor...   672   0.0  
M1HR94_9PHYC (tr|M1HR94) DNA topoisomerase II OS=Paramecium burs...   671   0.0  
M1HXD2_9PHYC (tr|M1HXD2) DNA topoisomerase II OS=Paramecium burs...   671   0.0  
I1RZG1_GIBZE (tr|I1RZG1) DNA topoisomerase 2 OS=Gibberella zeae ...   671   0.0  
M0VXE4_HORVD (tr|M0VXE4) DNA topoisomerase 2 OS=Hordeum vulgare ...   671   0.0  
M1IG07_9PHYC (tr|M1IG07) DNA topoisomerase II OS=Paramecium burs...   671   0.0  
M1HEE6_9PHYC (tr|M1HEE6) DNA topoisomerase II OS=Paramecium burs...   671   0.0  
N4U6N1_FUSOX (tr|N4U6N1) DNA topoisomerase 2 OS=Fusarium oxyspor...   670   0.0  
M1I7P4_9PHYC (tr|M1I7P4) DNA topoisomerase II OS=Paramecium burs...   670   0.0  
K3VTY4_FUSPC (tr|K3VTY4) DNA topoisomerase 2 OS=Fusarium pseudog...   670   0.0  
N1R6G8_FUSOX (tr|N1R6G8) DNA topoisomerase 2 OS=Fusarium oxyspor...   670   0.0  
M1HIH7_9PHYC (tr|M1HIH7) DNA topoisomerase II OS=Paramecium burs...   670   0.0  
G4VPA9_SCHMA (tr|G4VPA9) DNA topoisomerase 2 OS=Schistosoma mans...   670   0.0  
F9WZT5_MYCGM (tr|F9WZT5) DNA topoisomerase 2 OS=Mycosphaerella g...   670   0.0  

>I1MJQ7_SOYBN (tr|I1MJQ7) DNA topoisomerase 2 OS=Glycine max PE=3 SV=2
          Length = 1484

 Score = 1429 bits (3699), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 688/825 (83%), Positives = 741/825 (89%), Gaps = 3/825 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VANSGI+DTLLSWADFKQSKDLKK+DGTKTQRLRGIVKLEDANDAGGRNS+KCTLILTEG
Sbjct: 400  VANSGIVDTLLSWADFKQSKDLKKSDGTKTQRLRGIVKLEDANDAGGRNSEKCTLILTEG 459

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREAS+KQIMDNEEIQNIKKILGLQQNKEY
Sbjct: 460  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASSKQIMDNEEIQNIKKILGLQQNKEY 519

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN
Sbjct: 520  TSVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 579

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            GTKLSFYSMPEYESWRE+LGNNATGWKIKYYKGLGTSTPQEGREYFRDL KH+KDFVW+D
Sbjct: 580  GTKLSFYSMPEYESWRESLGNNATGWKIKYYKGLGTSTPQEGREYFRDLDKHKKDFVWDD 639

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIEMAFSKKKAEDRK+WIRNFEPG  RDH+A  INY+DFVNKELIL+SRADLQRS
Sbjct: 640  EQDGGAIEMAFSKKKAEDRKIWIRNFEPGTCRDHMAKYINYRDFVNKELILYSRADLQRS 699

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFKKKL KEIKVGQFIGYVSEHSAYHHGEQSLASTII MAQD
Sbjct: 700  IPSMVDGLKPGQRKILFCSFKKKLSKEIKVGQFIGYVSEHSAYHHGEQSLASTIINMAQD 759

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLLKPNGQFGTRNLGGKDHAS+RYIYTELN ITRC+FHE+DDKLLEYLNEDGR
Sbjct: 760  FVGSNNINLLKPNGQFGTRNLGGKDHASARYIYTELNTITRCIFHEDDDKLLEYLNEDGR 819

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP+WYIP+IPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL+ ETMVPMDPWY+G
Sbjct: 820  CIEPNWYIPVIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLSGETMVPMDPWYKG 879

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG IE+S KEGGY+VNG+VEEI+EQ+FRITELP+RKWTQDYKQFLESITDGSPNVKDPL
Sbjct: 880  FKGTIERSPKEGGYVVNGSVEEINEQTFRITELPVRKWTQDYKQFLESITDGSPNVKDPL 939

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+DFRQNGDDA VDIE+RMKLEKI  IMQEGLLKKFKLT++IST+NMHLFDAEGKIKKY+
Sbjct: 940  IDDFRQNGDDATVDIEVRMKLEKIVGIMQEGLLKKFKLTSSISTNNMHLFDAEGKIKKYD 999

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            NPEQILEEFFPLRL+YYERRK++IL N E+LLL+LDNKVRFILGVV+GEIVVSNRKKA+L
Sbjct: 1000 NPEQILEEFFPLRLEYYERRKKHILNNLEQLLLILDNKVRFILGVVNGEIVVSNRKKAEL 1059

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            L+ELQQKGFTPMP+KGKSAEPQVAGA                       KRGDYEYLLSM
Sbjct: 1060 LIELQQKGFTPMPRKGKSAEPQVAGANDEEEQEDDNNTREQETGSVEGVKRGDYEYLLSM 1119

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
            SIGTLTLE+VQ                 ATPSKS+W+             D  EAE+E+K
Sbjct: 1120 SIGTLTLEAVQKLLAEKAEKEKEFEILKATPSKSLWLKDLDELENKLDDIDSIEAEEERK 1179

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNA--ESDNSPME 835
            R SQA+++TS R + TKAAKKPPQPRK TKK KN   E+DNS ME
Sbjct: 1180 RSSQANRKTSNRGV-TKAAKKPPQPRKYTKKAKNVEPENDNSSME 1223


>I1L9S4_SOYBN (tr|I1L9S4) DNA topoisomerase 2 OS=Glycine max PE=3 SV=2
          Length = 1459

 Score = 1358 bits (3516), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 662/826 (80%), Positives = 712/826 (86%), Gaps = 29/826 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VANSGI+DTLLSWADFKQSKDLKK+DGTKTQRLRGIVKLEDANDAGGRNS+KCTLILTEG
Sbjct: 399  VANSGIVDTLLSWADFKQSKDLKKSDGTKTQRLRGIVKLEDANDAGGRNSEKCTLILTEG 458

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREAS+KQIMDNEEIQNIKKILGLQQNKEY
Sbjct: 459  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASSKQIMDNEEIQNIKKILGLQQNKEY 518

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN
Sbjct: 519  TSVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 578

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            GTKLSFYSMPEYESWRE+LGNNA GWKIKYYKGLGTSTPQEGREYF+DL KH+KDFVW+D
Sbjct: 579  GTKLSFYSMPEYESWRESLGNNANGWKIKYYKGLGTSTPQEGREYFQDLDKHKKDFVWDD 638

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIEMAFSKKKAEDRK+WIRNFEPG  RDH+A  INY+DFVNKELIL+SRADLQRS
Sbjct: 639  EQDGGAIEMAFSKKKAEDRKIWIRNFEPGTCRDHMAKYINYRDFVNKELILYSRADLQRS 698

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII MAQD
Sbjct: 699  IPSMVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIINMAQD 758

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLLKPNGQFGTRNLGGKDHAS+RYIYTEL+ ITRC+FHE+DDKLLEYLNEDGR
Sbjct: 759  FVGSNNINLLKPNGQFGTRNLGGKDHASARYIYTELSTITRCIFHEDDDKLLEYLNEDGR 818

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP+WYIP+IPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL+ ETMVPMDPWY+G
Sbjct: 819  CIEPTWYIPVIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLSGETMVPMDPWYKG 878

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG IE+S KEGGYIVNG+VEEI+E +FRITELPIRKWTQDYKQFLESITDGSPNVKDPL
Sbjct: 879  FKGTIERSPKEGGYIVNGSVEEINEHNFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 938

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+DFRQNGDDA V+IE+RMKLEKI  IMQE                      EGKIKKY+
Sbjct: 939  IDDFRQNGDDATVNIEVRMKLEKIVGIMQE----------------------EGKIKKYD 976

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            NPEQILEEFFPLRL+YYERRK +IL N ERLLL+LDNK RFILGVV+GEI+VSNRKKADL
Sbjct: 977  NPEQILEEFFPLRLEYYERRKNHILNNLERLLLILDNKARFILGVVNGEIIVSNRKKADL 1036

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            L+ELQ KGFTPMP+KGKSAEPQVAGA                       K GDYEYLLSM
Sbjct: 1037 LIELQHKGFTPMPRKGKSAEPQVAGA---NEDQEDDNTREQETESVEVAKGGDYEYLLSM 1093

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
            SIGTLTLE+VQ                  TPSKS+W+             D  EAE+E+K
Sbjct: 1094 SIGTLTLEAVQKLLAEKAEKEKEFKILKETPSKSLWLKDLDELEKKLDDIDSIEAEEERK 1153

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNA--ESDNSPMET 836
            R SQA+++  T++  TKAAKKPPQPRK TKK KN   E+DNS ME 
Sbjct: 1154 RSSQANRK--TKEAFTKAAKKPPQPRKYTKKAKNVEPENDNSSMEV 1197


>G7IWV9_MEDTR (tr|G7IWV9) DNA topoisomerase 2 OS=Medicago truncatula
            GN=MTR_3g031040 PE=3 SV=1
          Length = 1567

 Score = 1331 bits (3444), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 653/876 (74%), Positives = 714/876 (81%), Gaps = 56/876 (6%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SGI+DTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGG+NSDKCTLILTEG
Sbjct: 404  VEKSGIVDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGKNSDKCTLILTEG 463

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVR+ASNKQ+M+NEEIQNIKKILGLQQNKEY
Sbjct: 464  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVRDASNKQVMENEEIQNIKKILGLQQNKEY 523

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR----- 187
            +NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR     
Sbjct: 524  TNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRVSIIN 583

Query: 188  ---------------------------------------------AFHSNGTKLSFYSMP 202
                                                         A H NGTKLSFYSMP
Sbjct: 584  AVCCIFDNENTELYMPLSSRSLSVLILHLSLSLFFMMRYIYFAMQASHKNGTKLSFYSMP 643

Query: 203  EYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEMA 262
            EY++WRE LGN A  W IKYYKGLGTSTPQEGREYF+DL KHRKDF+WE++ DG+AIE+A
Sbjct: 644  EYDAWRERLGNTANAWAIKYYKGLGTSTPQEGREYFKDLDKHRKDFIWENELDGNAIELA 703

Query: 263  FSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLKP 322
            FSKKKAEDRK W+R+FEPG  RDH A  I+YKDFV+KELILFSRADLQRSIPS+VDGLKP
Sbjct: 704  FSKKKAEDRKNWMRSFEPGTCRDHEAKLISYKDFVDKELILFSRADLQRSIPSMVDGLKP 763

Query: 323  GQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL 382
            GQRKILFCSFKK L KE+KVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL
Sbjct: 764  GQRKILFCSFKKNLSKEVKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL 823

Query: 383  KPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPI 442
             PNGQFGTRNLGGKDHASSRYIYT+LN +TR LFH +DDKLLEYLNEDGRSIEP+WYIPI
Sbjct: 824  TPNGQFGTRNLGGKDHASSRYIYTQLNTVTRSLFHADDDKLLEYLNEDGRSIEPNWYIPI 883

Query: 443  IPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSAK 502
            IPLVLVNGSEGIGTGWSS+IPNYNPR+IIANVRRLLNDE MVPMDPWY+GF+G IEKSAK
Sbjct: 884  IPLVLVNGSEGIGTGWSSFIPNYNPREIIANVRRLLNDEEMVPMDPWYKGFRGTIEKSAK 943

Query: 503  EGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIEDFRQNGDD 562
            EGGYIVNG+VEEID+ +FRITELPIRKWTQDYK FLE  T+G+PNVKDPLIEDF+QNGDD
Sbjct: 944  EGGYIVNGSVEEIDDITFRITELPIRKWTQDYKTFLELTTEGAPNVKDPLIEDFKQNGDD 1003

Query: 563  AMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFF 622
            A+VDIE+RMK EK+A IMQEGL KKFKLT+TISTSNMHLFDAEGKIKK++ PEQILEEF+
Sbjct: 1004 AIVDIEVRMKAEKVAAIMQEGLFKKFKLTSTISTSNMHLFDAEGKIKKFDTPEQILEEFY 1063

Query: 623  PLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFT 682
            PLRL+YYE+RK+YIL N ERLLL+LDNKVRFILGVVSGEI+VSNRK+ +LL+EL+QKGFT
Sbjct: 1064 PLRLEYYEKRKKYILANLERLLLILDNKVRFILGVVSGEIIVSNRKRTELLIELKQKGFT 1123

Query: 683  PMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKR--GDYEYLLSMSIGTLTLE 740
            P+PKKGKSAEPQVAGA                           GDYEYLLS+SIGTLTLE
Sbjct: 1124 PIPKKGKSAEPQVAGANDENSEDQEDSERETASKSVNVEGATWGDYEYLLSLSIGTLTLE 1183

Query: 741  SVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKR 800
            SVQ                  TPSKS+W+             D  EAE+ +KR + ++K+
Sbjct: 1184 SVQKLLDEKADKENEFEILMGTPSKSLWLKDLDELEKKLDELDRIEAEEGQKRSTMSNKK 1243

Query: 801  TSTRDLGTKAAKKPPQPRKNTKKTK-NAESDNSPME 835
                 L TK AKKPPQPRKNTKK     E+DNS ME
Sbjct: 1244 NR---LATKPAKKPPQPRKNTKKANVEPENDNSSME 1276


>G7J2H1_MEDTR (tr|G7J2H1) DNA topoisomerase 2 OS=Medicago truncatula
            GN=MTR_3g085840 PE=3 SV=1
          Length = 1345

 Score = 1197 bits (3098), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 587/825 (71%), Positives = 664/825 (80%), Gaps = 48/825 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SGI+DTLLSWADF +SKD K TDG K QR+RGIV+LEDANDAGGRNS+KCTLILT+G
Sbjct: 368  VEKSGIMDTLLSWADFNESKDFKTTDGRKIQRIRGIVRLEDANDAGGRNSEKCTLILTDG 427

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAGLSVVGRDHYGVFPLR KLLNVR AS KQI DN+E Q I+KILGLQQNK+Y
Sbjct: 428  DSAKALAMAGLSVVGRDHYGVFPLRDKLLNVRVASKKQITDNQEFQIIQKILGLQQNKDY 487

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSF+VEFTTPIIR  HSN
Sbjct: 488  TNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFIVEFTTPIIRVSHSN 547

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            GTKLSFYSM +YE WR+ +GNNA  WKIKYYKGLGTST QEGREYF+DL KH K+F+W  
Sbjct: 548  GTKLSFYSMSDYEVWRKRIGNNANCWKIKYYKGLGTSTSQEGREYFQDLDKHMKEFIW-- 605

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
                                       P    D  A  I YK F+++ELILFSRA+LQRS
Sbjct: 606  ---------------------------PSTCHDLEAKLIRYKSFIDRELILFSRAELQRS 638

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFKKKL+KEIKV QFIGYVS HSAYHHGEQSLA+TIIGMAQD
Sbjct: 639  IPSMVDGLKPGQRKILFCSFKKKLYKEIKVSQFIGYVSLHSAYHHGEQSLANTIIGMAQD 698

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVG NNINLL PNGQFGTRNLGGKDHAS +YIYTELN +TR LFHE+DDKLL+YLNE+G+
Sbjct: 699  FVGGNNINLLNPNGQFGTRNLGGKDHASPKYIYTELNIVTRFLFHEDDDKLLKYLNEEGK 758

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WYIPIIPLVLVNGSE IGTGWSSYIPNYNPR+IIANVRRLLN+E MVPMDPWYRG
Sbjct: 759  SIEPNWYIPIIPLVLVNGSEEIGTGWSSYIPNYNPREIIANVRRLLNEEEMVPMDPWYRG 818

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F+G IEKS K+GGY VNG++ +IDEQ+FRITELPIRKWT+DYKQFLESIT+G+PNV DP 
Sbjct: 819  FRGTIEKSMKQGGYRVNGSMVKIDEQTFRITELPIRKWTEDYKQFLESITEGAPNVNDPF 878

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            IEDFRQNGDDA++DIE++MK +K+A +MQ GL KKFKLT+ +STSNMHLFDAEGKIKKY+
Sbjct: 879  IEDFRQNGDDAIIDIEVKMKPDKVASVMQ-GLFKKFKLTSIVSTSNMHLFDAEGKIKKYD 937

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             PEQILEEF+PLR+DYY+RRK+Y+L N ERLLL+LDNKVRFILGVV+GEI++ NRKKA+L
Sbjct: 938  TPEQILEEFYPLRMDYYQRRKKYMLANLERLLLILDNKVRFILGVVNGEIIMINRKKAEL 997

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            L+EL+QKGF+PM +KGKSAEPQV GA                         GDYEY LS+
Sbjct: 998  LIELKQKGFSPMLRKGKSAEPQVVGANDESSEGATW---------------GDYEYFLSL 1042

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
             IGTLTLESVQ                  TP+KS+W+             D KEAE+++K
Sbjct: 1043 PIGTLTLESVQKLLDEKAEKEKEHEVLMGTPTKSLWLKDLDEFEKKLDELDSKEAEEDRK 1102

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNA--ESDNSPME 835
            R +QASK+ +      K A KPPQPRKNTKKTKN   E+DNS ME
Sbjct: 1103 RSNQASKKAAN-GFAAKPAMKPPQPRKNTKKTKNVEPENDNSSME 1146


>F6HBC4_VITVI (tr|F6HBC4) DNA topoisomerase 2 OS=Vitis vinifera
            GN=VIT_13s0064g00560 PE=3 SV=1
          Length = 1489

 Score = 1119 bits (2894), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 553/829 (66%), Positives = 643/829 (77%), Gaps = 11/829 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V+ SG++++LLSWAD+KQ+KDLKKTDGTK QRL GI KLEDANDAGGRNS+KCTLILTEG
Sbjct: 398  VSKSGVVESLLSWADYKQNKDLKKTDGTKRQRLTGITKLEDANDAGGRNSEKCTLILTEG 457

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGR+HYGVFPLRGKLLNVR+A  KQI++N EIQNIK+ILGLQQ KEY
Sbjct: 458  DSAKALAMAGISVVGRNHYGVFPLRGKLLNVRDAQKKQILENAEIQNIKQILGLQQGKEY 517

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             ++KSLRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLK+PSF+VEF TPI++A H N
Sbjct: 518  DSIKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHRN 577

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G  LSFYSMPEYESW+E+LG NA+GW IKYYKGLGTST +EG+EYF+DLGKH+KDF+W D
Sbjct: 578  GRVLSFYSMPEYESWKESLGGNASGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFMWVD 637

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIE+AFSKKK E+RK W+R F+PG Y D     I Y DFVNKELILFS ADLQRS
Sbjct: 638  EKDGDAIELAFSKKKIEERKNWLRQFQPGTYLDQKEKLIKYSDFVNKELILFSMADLQRS 697

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFK+   KE K+ QF GYVSEHSAYHHGEQSLASTIIGMAQD
Sbjct: 698  IPSMVDGLKPGQRKILFCSFKRNFIKEAKIAQFSGYVSEHSAYHHGEQSLASTIIGMAQD 757

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL PNGQFGTR+ GGKDHAS+RYIYT L+PITR LF ++DD LL+YLNEDG+
Sbjct: 758  FVGSNNINLLLPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQ 817

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY+P IP+VLVNGSEGIGTGWSS IPNYNPRDIIANVRRLLN E M PMDPWYRG
Sbjct: 818  SIEPTWYVPTIPMVLVNGSEGIGTGWSSSIPNYNPRDIIANVRRLLNGEMMEPMDPWYRG 877

Query: 493  FKGIIEKS----AKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            F+G IEK+     +  GY V G +EE++E + RI+ELP+RKWTQDYK+FLESI  G+  +
Sbjct: 878  FRGTIEKTDPTKQESVGYTVKGIIEEVNETTLRISELPVRKWTQDYKEFLESIMTGNDKI 937

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
            KDP I+D++++ DD  V  E+ M  E + M  QEGLL+KFKLTT ISTSNMHLFD+ G I
Sbjct: 938  KDPFIKDYKEHNDDTTVHFEVIMSEENLLMAKQEGLLQKFKLTTKISTSNMHLFDSNGTI 997

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            KKYE PEQILEEFF LRL++YE+RK+ +L+N E  LL L+NKVRFILGVV GEI+VSNRK
Sbjct: 998  KKYETPEQILEEFFHLRLEFYEKRKRVLLDNLELELLKLENKVRFILGVVRGEIIVSNRK 1057

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            +ADL  EL QKGFTP PKK KS E  VAGA                       +  DYEY
Sbjct: 1058 RADLFHELHQKGFTPFPKKSKSVEIAVAGA----TDDTEEAEENTDAVSKGGVRATDYEY 1113

Query: 729  LLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAE 788
            LLSM+IGTLTLE VQ                     K++W+            QD  +A 
Sbjct: 1114 LLSMAIGTLTLEKVQELCADRDKLNKGVDDLKKATPKALWITDLDALERELDEQDKNDAR 1173

Query: 789  DEKKRISQASKRTSTRDLGTKAAKKPPQ-PRKNTKKTKNAESDNSPMET 836
             E+ R    S+  S  + G K +++ P+ PRKN KK  NAE     M+ 
Sbjct: 1174 AEETRKQLKSRVMS--EAGMKVSRQAPKNPRKNNKKANNAEPAAETMDV 1220


>M5X8I4_PRUPE (tr|M5X8I4) Uncharacterized protein OS=Prunus persica
            GN=PRUPE_ppa000202mg PE=4 SV=1
          Length = 1471

 Score = 1105 bits (2857), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 526/759 (69%), Positives = 616/759 (81%), Gaps = 6/759 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI+D+LLSWA+FKQ+KDLKKTDGTKT+R+  I KLEDAN AGG+NS+KCTLILTEG
Sbjct: 401  VAKSGIVDSLLSWANFKQNKDLKKTDGTKTERVHNINKLEDANLAGGKNSEKCTLILTEG 460

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAGL+VVGRDHYGVFPLRGKLLNVREAS  Q+ DNEEI+NIK+ILGLQQ+KEY
Sbjct: 461  DSAKALAMAGLAVVGRDHYGVFPLRGKLLNVREASAIQVRDNEEIKNIKRILGLQQDKEY 520

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +++KSLRYG LMIM DQDHDGSHIKGLLINFIHSFWPSLLK+PSF+VEF TPI++A H N
Sbjct: 521  TSLKSLRYGSLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKN 580

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G  L+FYSMPEYE+W+E+L  NA+GW IKYYKGLGTST +EGR+YF++L  H+KDF+W D
Sbjct: 581  GKSLAFYSMPEYEAWKESLRGNASGWSIKYYKGLGTSTSKEGRDYFQNLAMHKKDFIWID 640

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIE+AFSKKK E+RK W+R FEP  + D     I Y DFV+KELI FS ADLQRS
Sbjct: 641  ERDGEAIELAFSKKKIEERKNWLRQFEPSVHLDQKEKLIKYSDFVHKELIQFSMADLQRS 700

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFK+   KE KV QF GYVSEHSAYHHGEQSLASTIIGMAQD
Sbjct: 701  IPSMVDGLKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQD 760

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNNINLL+PNGQFGTRNLGGKDHAS+RYIYT L+PITR LF ++DD+LL+YLNEDG+
Sbjct: 761  YVGSNNINLLQPNGQFGTRNLGGKDHASARYIYTRLSPITRFLFPKDDDRLLDYLNEDGQ 820

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY+PIIP VLVNGSEGIGTGWSSYIPNYN RDI+ANVRRLLN E MVPMDPWYRG
Sbjct: 821  SIEPTWYVPIIPTVLVNGSEGIGTGWSSYIPNYNTRDIVANVRRLLNGEAMVPMDPWYRG 880

Query: 493  FKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            F G IEK+ KE G  Y V G +EE +E + RI+ELPIR+WTQDYK+FLESI+ G+   KD
Sbjct: 881  FSGTIEKTVKESGVSYTVCGVIEEGNETTVRISELPIRRWTQDYKEFLESISQGNDKAKD 940

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKK 610
            P IE F Q+ D + VDI + +  E +    QEGLLKKFKLTT+ISTSNMHLFD +G IKK
Sbjct: 941  PFIEGFTQHSDHSTVDIIVHLPEENLMAARQEGLLKKFKLTTSISTSNMHLFDPKGVIKK 1000

Query: 611  YENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKA 670
            Y+ PEQILEEFF LRL++YE+RK+ +L+N E  LL L+NKVRFIL VV+GEI+VSNR++A
Sbjct: 1001 YDTPEQILEEFFHLRLEFYEKRKKVLLDNLEMELLKLENKVRFILAVVNGEIIVSNRRRA 1060

Query: 671  DLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLL 730
            DL +ELQQKGFTP PKK K+ EP+VAGA                       +  DYEYL+
Sbjct: 1061 DLFLELQQKGFTPFPKKTKAQEPEVAGA----IEDTEETEENSESASGNGARISDYEYLI 1116

Query: 731  SMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            SM+IGTLT+E VQ                  +  +S+W+
Sbjct: 1117 SMAIGTLTIERVQALCADRDKVNNEVAELRNSTPRSLWL 1155


>Q8GSC4_TOBAC (tr|Q8GSC4) DNA topoisomerase 2 OS=Nicotiana tabacum PE=2 SV=1
          Length = 1482

 Score = 1063 bits (2750), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 529/824 (64%), Positives = 636/824 (77%), Gaps = 17/824 (2%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N GI++TLLSWADFK SKDLKKTDG K+++++ + KLEDANDAGGRNS+KCTLILTEGDS
Sbjct: 397  NIGIVETLLSWADFKNSKDLKKTDGKKSEKVK-VEKLEDANDAGGRNSEKCTLILTEGDS 455

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAMAG+SVVGRDHYGVFPLRGKLLNVREAS+KQ+ +N+EI+ IKKILGLQ  KEY +
Sbjct: 456  AKALAMAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIEAIKKILGLQTGKEYDS 515

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
            VKSLRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSF++EF TPI++A H +G 
Sbjct: 516  VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSGK 575

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             LSFY+MPEYESWR++LG N++GW IKYYKGLGTST +EG+EYF+DL KHRKDF+W D+ 
Sbjct: 576  ILSFYTMPEYESWRKSLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQ 635

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            DG +IE+AFSKKK E RK W+R FEPG + D     I+Y +FVNKELILFS ADLQRSIP
Sbjct: 636  DGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIP 695

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S++DGLKPGQRKILFC+FK+   KE KV QF GYVSEHSAYHHGEQSL+STIIGMAQD+V
Sbjct: 696  SMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYV 755

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNN+NLL+PNGQFGTRN+GGKDHASSRYIYT L+PI R LF + DD + +YLNEDG+ I
Sbjct: 756  GSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTIHDYLNEDGQYI 815

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP+WY+PI+P+VL+NGSEGIGTGWSSY+PNYNPRD++ANVRRLLNDE M PMDPWY+GFK
Sbjct: 816  EPTWYVPIVPMVLINGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGFK 875

Query: 495  GIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G IEK+A KE G  Y V G +EE++E + RI+ELP+R+WT+DYKQFLES+T  +   KDP
Sbjct: 876  GTIEKTATKEAGATYTVTGIIEEVNETTLRISELPVRRWTEDYKQFLESMTVSNDKAKDP 935

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I++ R  GD+  V  E+ M  E + +  QEGLLKKFKL TTISTSNMHLFD+ GKIKKY
Sbjct: 936  FIKEVRAYGDENSVCFEVIMSEENLILAQQEGLLKKFKLATTISTSNMHLFDSNGKIKKY 995

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
            +NPE ILEEF+ +RL+YYE+RK+ +LE  E  LL ++NKV+FILGVV  EI+V+NRK+AD
Sbjct: 996  DNPEDILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKVEIIVNNRKRAD 1055

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            LL+EL++KGFTP PKK K+ E  VA                         + GDY+YLLS
Sbjct: 1056 LLLELKEKGFTPFPKK-KAVEAVVADT--------SDDAEDSEEELNRGVRAGDYDYLLS 1106

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEK 791
            M IGTLTLE VQ                     K +W+            QD  + + E+
Sbjct: 1107 MPIGTLTLEKVQELCAERDQLNGEVEDMRNATPKLLWLKDLDVLEKQLDEQDKIDIQAEE 1166

Query: 792  KRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPME 835
             R  +  K+      G KA K  P+PRKN KK    ES   PM+
Sbjct: 1167 AR--EKIKKKVMNAAGLKAPK--PKPRKNVKKASVVESTAEPMD 1206


>M1A903_SOLTU (tr|M1A903) DNA topoisomerase 2 OS=Solanum tuberosum
            GN=PGSC0003DMG400006793 PE=3 SV=1
          Length = 1487

 Score = 1060 bits (2740), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 518/782 (66%), Positives = 616/782 (78%), Gaps = 10/782 (1%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N GI+D+LLSWADFK SKDLKKTDG K+ +++ + KLEDANDAGGRNSDKCTLILTEGDS
Sbjct: 398  NIGIVDSLLSWADFKNSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDS 456

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAMAG+SVVGRDHYGVFPLRGKLLNVREAS+KQ+ +N+EI++IKKILGLQ  KEY +
Sbjct: 457  AKALAMAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYES 516

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
            VKSLRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSF+VEF TPI++A H +G 
Sbjct: 517  VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGR 576

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             L+FY+MPEYE+WR +LG  ++GW IKYYKGLGTST +EG+EYF+DL KHRKDF+W D+ 
Sbjct: 577  ILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQ 636

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            DG +IE+AFSKKK E RK W+R FEPG + D     I+Y +FVNKELILFS ADLQRSIP
Sbjct: 637  DGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIP 696

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S++DGLKPGQRKILFC+FK+   KE KV QF GYVSEHSAYHHGEQSL+STIIGMAQD+V
Sbjct: 697  SMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYV 756

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNN+NLL+PNGQFGTRN+GGKDHASSRYIYT L+PI R LF ++DD +L+YLNEDG+SI
Sbjct: 757  GSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSI 816

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP+WYIPIIP+VLVNGSEGIGTGWSSY+PNYNPRD++ANVRRLLNDE M PMDPWY+GFK
Sbjct: 817  EPTWYIPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFK 876

Query: 495  GIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G IEK+A KE G  Y V G +EE  E + RI+ELP+R+WT+DYKQFLES+T  +   KD 
Sbjct: 877  GTIEKTATKETGATYTVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDA 936

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I++ R  GD+  V  E+ M  E + +  QEGLLKKFKLTTTISTSNMHLFD++GKIKKY
Sbjct: 937  FIKEVRAYGDENSVCFEVIMSEENLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKY 996

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
            + PE+ILEEF+ +RL+YYE+RK+ +LE  E  LL ++NKVRFILGVV GEI+V+NRK+AD
Sbjct: 997  DAPEEILEEFYHVRLEYYEKRKKTLLEILELELLRIENKVRFILGVVKGEIIVNNRKRAD 1056

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            LL+EL+ KGFTP PKK K  E  VA +                       +  DY+YLLS
Sbjct: 1057 LLLELKNKGFTPFPKK-KPVEAVVADS-----TDDAEDSEESPEESNKGVRASDYDYLLS 1110

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEK 791
            M+IGTLTLE VQ                     K +WM            QD  + + E+
Sbjct: 1111 MAIGTLTLEKVQELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKLDIQTEE 1170

Query: 792  KR 793
             R
Sbjct: 1171 AR 1172


>M1A904_SOLTU (tr|M1A904) DNA topoisomerase 2 OS=Solanum tuberosum
            GN=PGSC0003DMG400006793 PE=3 SV=1
          Length = 1486

 Score = 1059 bits (2739), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 518/782 (66%), Positives = 616/782 (78%), Gaps = 10/782 (1%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N GI+D+LLSWADFK SKDLKKTDG K+ +++ + KLEDANDAGGRNSDKCTLILTEGDS
Sbjct: 398  NIGIVDSLLSWADFKNSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDS 456

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAMAG+SVVGRDHYGVFPLRGKLLNVREAS+KQ+ +N+EI++IKKILGLQ  KEY +
Sbjct: 457  AKALAMAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYES 516

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
            VKSLRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSF+VEF TPI++A H +G 
Sbjct: 517  VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGR 576

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             L+FY+MPEYE+WR +LG  ++GW IKYYKGLGTST +EG+EYF+DL KHRKDF+W D+ 
Sbjct: 577  ILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQ 636

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            DG +IE+AFSKKK E RK W+R FEPG + D     I+Y +FVNKELILFS ADLQRSIP
Sbjct: 637  DGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIP 696

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S++DGLKPGQRKILFC+FK+   KE KV QF GYVSEHSAYHHGEQSL+STIIGMAQD+V
Sbjct: 697  SMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYV 756

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNN+NLL+PNGQFGTRN+GGKDHASSRYIYT L+PI R LF ++DD +L+YLNEDG+SI
Sbjct: 757  GSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSI 816

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP+WYIPIIP+VLVNGSEGIGTGWSSY+PNYNPRD++ANVRRLLNDE M PMDPWY+GFK
Sbjct: 817  EPTWYIPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFK 876

Query: 495  GIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G IEK+A KE G  Y V G +EE  E + RI+ELP+R+WT+DYKQFLES+T  +   KD 
Sbjct: 877  GTIEKTATKETGATYTVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDA 936

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I++ R  GD+  V  E+ M  E + +  QEGLLKKFKLTTTISTSNMHLFD++GKIKKY
Sbjct: 937  FIKEVRAYGDENSVCFEVIMSEENLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKY 996

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
            + PE+ILEEF+ +RL+YYE+RK+ +LE  E  LL ++NKVRFILGVV GEI+V+NRK+AD
Sbjct: 997  DAPEEILEEFYHVRLEYYEKRKKTLLEILELELLRIENKVRFILGVVKGEIIVNNRKRAD 1056

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            LL+EL+ KGFTP PKK K  E  VA +                       +  DY+YLLS
Sbjct: 1057 LLLELKNKGFTPFPKK-KPVEAVVADS-----TDDAEDSEESPEESNKGVRASDYDYLLS 1110

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEK 791
            M+IGTLTLE VQ                     K +WM            QD  + + E+
Sbjct: 1111 MAIGTLTLEKVQELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKLDIQTEE 1170

Query: 792  KR 793
             R
Sbjct: 1171 AR 1172


>K4AYE0_SOLLC (tr|K4AYE0) DNA topoisomerase 2 OS=Solanum lycopersicum
            GN=Solyc01g087500.2 PE=3 SV=1
          Length = 1478

 Score = 1058 bits (2736), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 528/825 (64%), Positives = 632/825 (76%), Gaps = 17/825 (2%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N GI+D+LLSWADFK SKDLKKTDG K+ +++ + KLEDANDAGGRNSDKCTLILTEGDS
Sbjct: 398  NIGIVDSLLSWADFKLSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDS 456

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAMAG+SVVGRDHYGVFPLRGKLLNVREAS+KQ+ +N+EI++IKKILGLQ  KEY +
Sbjct: 457  AKALAMAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDS 516

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
            VKSLRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSF+VEF TPI++A H +G 
Sbjct: 517  VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGR 576

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             L+FY+MPEYE+WR +LG  ++GW IKYYKGLGTST +EG+EYF+DL KHRKDFVW D+ 
Sbjct: 577  ILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQ 636

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            DG +IE+AFSKKK E RK W+R FEPG + D     I+Y +FVNKELILFS ADLQRSIP
Sbjct: 637  DGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIP 696

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S++DGLKPGQRKILFC+FK+   KE KV QF GYVSEHSAYHHGEQSL+STIIGMAQD+V
Sbjct: 697  SMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYV 756

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNN+NLL+PNGQFGTRN+GGKDHASSRYIYT L+PI R LF ++DD +L+YLNEDG+SI
Sbjct: 757  GSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSI 816

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP+WY+P+IP VLVNGSEGIGTGWSSY+PNYNPRD++ANVRRLLNDE M PMDPWY+GFK
Sbjct: 817  EPTWYVPVIPTVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFK 876

Query: 495  GIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G IEK+A KE G  Y V G +EE+ E + RI+ELP+R+WT+DYKQFLES+T  +   KD 
Sbjct: 877  GKIEKTATKETGATYTVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDS 936

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I++ R  GD+  V  E+ M  + + +  QEGLLKKFKLTTTISTSNMHLFD++GKIKKY
Sbjct: 937  FIKEVRAYGDENSVCFEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKY 996

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
            + PE+ILEEF+ +RL+YYE+RK+ +LE  E  LL ++NKV+FILGVV GEI+V+NRK+A+
Sbjct: 997  DAPEEILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAE 1056

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            LL+EL+ KGFTP PKK K  E     A                       +  DY+YLLS
Sbjct: 1057 LLLELKNKGFTPFPKK-KPVE-----AVVADSTDDADDSEESPEESSRGVRASDYDYLLS 1110

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEK 791
            M+IGTLTLE VQ                     K +WM            QD  + + E+
Sbjct: 1111 MAIGTLTLEKVQELCADRDKLNAEVEDMRNATPKHLWMKDLDVLDKQLDEQDKIDIQTEE 1170

Query: 792  KRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMET 836
             R     K     +   KAA K P+PRK  KK   AES    M+ 
Sbjct: 1171 AREKLKKK---VMNAAGKAAPK-PKPRKTNKK---AESTAESMDV 1208


>M0T361_MUSAM (tr|M0T361) DNA topoisomerase 2 OS=Musa acuminata subsp. malaccensis
            PE=3 SV=1
          Length = 1449

 Score = 1053 bits (2722), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 521/831 (62%), Positives = 627/831 (75%), Gaps = 37/831 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SG+++TLL+WADFKQSK+LKKTDG K QR+ GI KLEDANDAGGRNSDKCTL+LTEG
Sbjct: 408  VAKSGVVNTLLTWADFKQSKELKKTDGAKRQRITGIPKLEDANDAGGRNSDKCTLVLTEG 467

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGR++YGVFPLRGKLLNVREA++KQIMDN EIQN+K+ILGLQ  KEY
Sbjct: 468  DSAKALAMAGISVVGRNYYGVFPLRGKLLNVREANHKQIMDNAEIQNVKQILGLQHGKEY 527

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
             + K LRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSFMVEF TP+++A ++ 
Sbjct: 528  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFMVEFITPLLKATNNK 587

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            N T LSFYSMPEYE+W+E+LG N++GW IKYYKGLGTS  +EG+EYF+D+ KH+K+FVW 
Sbjct: 588  NKTVLSFYSMPEYEAWKESLGGNSSGWSIKYYKGLGTSKSEEGKEYFKDIDKHKKEFVWA 647

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D+ DG+AIE+AFSKKK E RK W+R FEP NY D     I Y DF+NKELILFSRADLQR
Sbjct: 648  DEQDGNAIELAFSKKKIEARKNWLRQFEPDNYLDQKQKLIKYSDFINKELILFSRADLQR 707

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILFC+FK+   K+ KV QF+GYVSE SAYHHGEQSL++TIIGMAQ
Sbjct: 708  SIPSMVDGLKPGQRKILFCAFKRNFVKQAKVAQFVGYVSEKSAYHHGEQSLSTTIIGMAQ 767

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL P GQFGTR+ GGKDHAS+RYI+T ++P+TR LF ++DD LL+YLNEDG
Sbjct: 768  DFVGSNNINLLLPEGQFGTRHQGGKDHASARYIFTCMSPVTRFLFSKDDDILLDYLNEDG 827

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEP+WY+P+IP VLVNGSEGIGTGWSSY+PNYNP+DI+AN+RRLLNDE M PMDPWYR
Sbjct: 828  QSIEPTWYMPVIPTVLVNGSEGIGTGWSSYVPNYNPKDIVANIRRLLNDEPMQPMDPWYR 887

Query: 492  GFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            GFKG IEKSA KE G  Y + G +EE+D  + RITELP+R+WTQDYK+FLES+  G+  +
Sbjct: 888  GFKGRIEKSATKEAGVTYTIAGVIEEVDNTTLRITELPVRRWTQDYKEFLESMMTGNDKI 947

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
            K+P I+D+R+  DD  V  E+ +  E + +  QEGL KKFKLTTTI T+NMHLFD++G I
Sbjct: 948  KEPFIKDYREYNDDKTVHFEVTLTEENMNIARQEGLEKKFKLTTTIGTTNMHLFDSKGVI 1007

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            KKY+NPEQILEEFF +R ++YE+RK+ +L+N E  LL LDNK RFILGVV GEI+VSNRK
Sbjct: 1008 KKYDNPEQILEEFFHMRYEFYEKRKKALLDNLELDLLKLDNKARFILGVVRGEIIVSNRK 1067

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            +ADL +ELQQKG    P+ GK                                K  DYEY
Sbjct: 1068 RADLFLELQQKG----PEVGKGG-----------------------------VKASDYEY 1094

Query: 729  LLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAE 788
            L+ M IG+LTLE VQ                  T +KS+W+             + K+AE
Sbjct: 1095 LMCMPIGSLTLEKVQELCADKDRLEGEVDELRRTSAKSLWLKELDALEEELDKLERKDAE 1154

Query: 789  DEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMETGKP 839
            DE  R     K T+         KKP +   N      +E+  +     KP
Sbjct: 1155 DEGVRKEMRMKTTAGLAPSRPGPKKPRKNAANNSSVVGSEATATDAGQKKP 1205


>Q2L363_MALDO (tr|Q2L363) DNA topoisomerase 2 OS=Malus domestica
            GN=Md49N23_TopII.010 PE=3 SV=1
          Length = 1467

 Score = 1047 bits (2708), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 524/831 (63%), Positives = 623/831 (74%), Gaps = 53/831 (6%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI+D+LLSWA+FKQ+KDLKKTDGTKT+R+  I KLEDAN AGG+NS+KCTLILTEG
Sbjct: 404  VAKSGIVDSLLSWANFKQNKDLKKTDGTKTERVHNINKLEDANYAGGKNSEKCTLILTEG 463

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAGL+VVGRDHYGVFPLRGKLLNVREAS                         
Sbjct: 464  DSAKALAMAGLAVVGRDHYGVFPLRGKLLNVREAS------------------------- 498

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
                          A QDHDGSHIKGLLINFIHSFWPSLLK+PSF+VEF TPI++A H N
Sbjct: 499  --------------ATQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKN 544

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G  L+FYSMPEYE+W+E+L  NA+GW IKYYKGLGTST +EGR+YF++L +H+KDF+W D
Sbjct: 545  GNTLAFYSMPEYEAWKESLRGNASGWSIKYYKGLGTSTSKEGRDYFQNLVQHKKDFIWID 604

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIE+AFSKKK E+RK W+R FEPG + D     I Y DFV+KELI FS ADLQRS
Sbjct: 605  ERDGEAIELAFSKKKIEERKNWLRQFEPGVHLDQKEKLIKYSDFVHKELIQFSMADLQRS 664

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILF SFK+   KE KV QF GYVSEHSAYHHGEQSLASTIIGMAQD
Sbjct: 665  IPSMVDGLKPGQRKILFSSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQD 724

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL+PNGQFGTRNLGGKDHAS+RYIYT L+PITR LF ++DD+LL+YLNEDG+
Sbjct: 725  FVGSNNINLLQPNGQFGTRNLGGKDHASARYIYTRLSPITRFLFSKDDDRLLDYLNEDGQ 784

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY+PIIP VLVNGSEGIGTGWSSYIPNYNPRDI+ANVRRLL+ + MVPMDPWYRG
Sbjct: 785  SIEPTWYVPIIPTVLVNGSEGIGTGWSSYIPNYNPRDIVANVRRLLDGDAMVPMDPWYRG 844

Query: 493  FKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            F G IEK+ KE G  Y   G +EE+ E S RI+ELPIR+WTQDYK+FLESI++G+   KD
Sbjct: 845  FTGTIEKTVKESGVSYTACGIIEEVSETSLRISELPIRRWTQDYKEFLESISEGNDKAKD 904

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKK 610
            P IE F Q+ D + VDI + ++ EK+    QEGLLKKFKLTT+ISTSNMHLFD +G IKK
Sbjct: 905  PFIEGFTQHSDHSTVDIIVHLREEKLMAAKQEGLLKKFKLTTSISTSNMHLFDRKGVIKK 964

Query: 611  YENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKA 670
            Y+ PEQILE+FF LRL++YE+RK+ +LE+ E  LL L+NKVRFILGVV+GEI+VSNRK+A
Sbjct: 965  YDTPEQILEDFFHLRLEFYEKRKKVLLEDLELELLKLENKVRFILGVVNGEIIVSNRKRA 1024

Query: 671  DLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLL 730
            DL +ELQQKGFTP PKK K+ EP+VAGA                       +  DYEYL+
Sbjct: 1025 DLFLELQQKGFTPFPKKTKALEPEVAGA----TENTEDAEENSEAAIEKGARISDYEYLI 1080

Query: 731  SMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKE--AE 788
            SM+IGTLT+E VQ                  +  +S+W+             +  E  AE
Sbjct: 1081 SMAIGTLTIERVQALLADRDKANAEVDELRKSTPRSLWLKDLDALEMELDVLEKSEALAE 1140

Query: 789  DEKKRISQASKRTSTRDL-GTKAAKKPPQPRKNTKKTKNAESDNSPMETGK 838
            + KK+      RT  +++  +KA+K+ P+PRKNTKK  NAE+ +S ME  +
Sbjct: 1141 EAKKK-----ARTQVKNVPASKASKQAPKPRKNTKKANNAEAASSVMEIAR 1186


>M0SVF6_MUSAM (tr|M0SVF6) DNA topoisomerase 2 OS=Musa acuminata subsp. malaccensis
            PE=3 SV=1
          Length = 1462

 Score = 1047 bits (2707), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 516/814 (63%), Positives = 617/814 (75%), Gaps = 41/814 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SG+++TLL+WADFKQSK+LKKTDG K QR+ GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 402  VAKSGVVNTLLTWADFKQSKELKKTDGAKRQRITGIPKLEDANDAGGKNSDKCTLILTEG 461

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGR++YGVFPLRGKLLNVREA++KQI+DN EIQNIK+ILGLQ  KEY
Sbjct: 462  DSAKALAMAGISVVGRNYYGVFPLRGKLLNVREANHKQILDNAEIQNIKQILGLQHGKEY 521

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSFMVEF TP+++    N
Sbjct: 522  DSAKGLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFMVEFITPLLKVSLDN 581

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             T LSFYSMPEYE+W+E+LG NA GW IKYYKGLGTS  +EG++YF+ + KH+KDFVW D
Sbjct: 582  DTVLSFYSMPEYEAWKESLGGNANGWSIKYYKGLGTSKSEEGKDYFKAIDKHKKDFVWVD 641

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFE----PGNYRDHVASRINYKDFVNKELILFSRAD 308
            + DG AIE+AFSKKK E RK W+R FE    P NY D     I Y DF+NKELILFSRAD
Sbjct: 642  EQDGDAIELAFSKKKIEARKNWLRQFEARCMPENYLDQREKLIKYSDFINKELILFSRAD 701

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
            LQRSIPS+VDGLKPGQRKILFC+FK+   K+ KV QF+GYVSE SAYHHGEQSLA+TIIG
Sbjct: 702  LQRSIPSMVDGLKPGQRKILFCAFKRNFVKQAKVAQFVGYVSEKSAYHHGEQSLATTIIG 761

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            MAQDFVGSNNINLL+P GQFGTR+ GGKDHAS+RYI+T L+PITR LF ++DD LL+YLN
Sbjct: 762  MAQDFVGSNNINLLQPEGQFGTRHQGGKDHASARYIFTCLSPITRFLFPKDDDILLDYLN 821

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            EDG+SIEP+WY+PIIP+VL NGSEGIGTGWSSYIPNYNP+DI+ANVRRLLN+E M PMDP
Sbjct: 822  EDGQSIEPTWYMPIIPMVLANGSEGIGTGWSSYIPNYNPKDIVANVRRLLNNEPMQPMDP 881

Query: 489  WYRGFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            WYRGF G IEKSA KE G  Y + G +EE++  + RITELPIR+WTQDYK+FLES+  G+
Sbjct: 882  WYRGFTGRIEKSATKEAGVTYTITGAIEEVNGTTLRITELPIRRWTQDYKEFLESMMTGN 941

Query: 546  PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
               K+P I+D+R+  DD  V  E+ +  + +++  QEGL KKFKLTT+I T+NMHLFD +
Sbjct: 942  DKSKEPFIKDYREYNDDKTVHFEVTLTEDNLSIARQEGLEKKFKLTTSIGTTNMHLFDPK 1001

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G IKKY+N EQILEEFF LR ++YE+RK+ +L+N E  LL LDNKVRFILGVV GEI+V+
Sbjct: 1002 GVIKKYDNSEQILEEFFHLRYEFYEKRKKALLDNLEFQLLKLDNKVRFILGVVRGEIIVN 1061

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
            NRK+ADL +ELQQK      ++ +S E    G                        K  D
Sbjct: 1062 NRKRADLFLELQQKD----EQEEESPEAGKRGV-----------------------KASD 1094

Query: 726  YEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGK 785
            YEYL+SM IGTLTLE VQ                  T  +S+W+             + K
Sbjct: 1095 YEYLMSMPIGTLTLEKVQELCAEKDKLEGEVDELRRTSPRSLWLKELDALEEELDKLERK 1154

Query: 786  EAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRK 819
            +AE E+ R+   +    +R       + P +PRK
Sbjct: 1155 DAEAEEIRMKNNAGAVPSR-------QAPKKPRK 1181


>B9HNR6_POPTR (tr|B9HNR6) DNA topoisomerase 2 OS=Populus trichocarpa
            GN=POPTRDRAFT_557797 PE=3 SV=1
          Length = 1482

 Score = 1033 bits (2672), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 532/828 (64%), Positives = 631/828 (76%), Gaps = 23/828 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA S I+D LLSWA FK++K+LKKTDGTKT ++  + KLEDAN+AGGR S+KCTLILTEG
Sbjct: 396  VAKSDIVDNLLSWAKFKENKELKKTDGTKTAKV-NVPKLEDANEAGGRYSEKCTLILTEG 454

Query: 73   DSAKALAMAG---LSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            DSAKALA+AG   LS + R+ YGVFPLRGKLLNVREA++KQ+ +N+EI++IKKILGLQ +
Sbjct: 455  DSAKALAIAGVAGLSQMERNFYGVFPLRGKLLNVREATSKQLKENKEIESIKKILGLQHD 514

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y NVKSLRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLKVPSF+VEF TPI++A 
Sbjct: 515  KQYINVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKAT 574

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
            H NGT LSFYSMPEYESW+E+L  NA+GW IKYYKGLGTST +EG++YF++L KH+KDF+
Sbjct: 575  HRNGTVLSFYSMPEYESWKESLSGNASGWSIKYYKGLGTSTSKEGKDYFKNLHKHKKDFL 634

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
            W D+ DG AIE+AFSKKK E RK W+R  EPG + DH    I Y DF+NKELILFS ADL
Sbjct: 635  WMDELDGDAIELAFSKKKIEARKNWLRQHEPGTHLDHNQKIIKYSDFINKELILFSMADL 694

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
            QRSIPS+VDGLKPGQRKILFCSFK+   KE KV QF GYVSEHSAYHHGEQSLA TIIGM
Sbjct: 695  QRSIPSMVDGLKPGQRKILFCSFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGM 754

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQDFVGSNNINLL+PNGQFGTR++GGKDHAS+RYIYT+L+PITR LF ++DD LL+YL+E
Sbjct: 755  AQDFVGSNNINLLQPNGQFGTRSVGGKDHASARYIYTQLSPITRFLFPKDDDGLLDYLDE 814

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            DG++IEP+WY+PIIP VLVNG EGIGTGWS++IPNYNPRD++AN+RRLLN E M PM+PW
Sbjct: 815  DGQTIEPTWYMPIIPTVLVNGCEGIGTGWSTFIPNYNPRDVVANIRRLLNGEMMEPMNPW 874

Query: 490  YRGFKGIIEKSA-KEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            YRGFKG IEK A KEGG   Y VNG + E++E + RITELPIR+WT DYK FL S+T+G+
Sbjct: 875  YRGFKGTIEKGASKEGGCSSYTVNGVINEVNETTLRITELPIRRWTDDYKAFLNSVTEGT 934

Query: 546  PN-----VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMH 600
             +      KDP ++DFR+ GDDA V  E+++  E + +  QEGLLKKFKLTTTISTSNMH
Sbjct: 935  RDENGNLPKDPFVKDFRKYGDDAAVHFEVQLSEENMLVAKQEGLLKKFKLTTTISTSNMH 994

Query: 601  LFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSG 660
            LFD+ G IKKY+NPEQILE FF LRL+YYE RK+ +LEN E  LL L+NKVRFILGVV G
Sbjct: 995  LFDSAGVIKKYDNPEQILENFFHLRLEYYETRKKVLLENLEFELLKLENKVRFILGVVRG 1054

Query: 661  EIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXX 720
            EI+V+NRK+ADLL+EL QKGF P+PKK K+    VAGA                      
Sbjct: 1055 EIIVNNRKRADLLLELHQKGFNPIPKKSKAV---VAGA-------TDDTEEAEDSPDVSG 1104

Query: 721  XKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXX 780
             +  DY+YLLSM+IGTLTLE VQ                  T  K +W+           
Sbjct: 1105 VRASDYDYLLSMAIGTLTLERVQQLCADRDKLNGEVDSLRKTTPKVLWVKDLEALEMQLD 1164

Query: 781  XQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAE 828
              D  +AE E+ R                + + P  PRKNTKK  N E
Sbjct: 1165 MLDEYDAEAEEARRKLKGGGAKGEAGFKVSKQAPKYPRKNTKKAINEE 1212


>A9RWX5_PHYPA (tr|A9RWX5) DNA topoisomerase 2 (Fragment) OS=Physcomitrella patens
            subsp. patens GN=PHYPADRAFT_120620 PE=3 SV=1
          Length = 1238

 Score = 1026 bits (2654), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 506/821 (61%), Positives = 605/821 (73%), Gaps = 19/821 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA  G+++ +L+WADFKQSK+LKK DG K QR+ GI KL+DANDAGGR+S++CTLILTEG
Sbjct: 400  VAKCGVVENVLTWADFKQSKELKKNDGAKRQRITGIPKLDDANDAGGRSSEQCTLILTEG 459

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAM+G+SVVGRD YGVFPLRGKLLNVREAS+KQIM+N EI NIK+ILGLQ  K+Y
Sbjct: 460  DSAKALAMSGISVVGRDKYGVFPLRGKLLNVREASHKQIMENAEITNIKRILGLQHGKDY 519

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             N KSLRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLK+PSF+VEF TPI++A  SN
Sbjct: 520  DNTKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKA--SN 577

Query: 193  GTK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              K LSFY+MPEYE+W+E+L     GW IKYYKGLGTST +EG+EYFR+L KH+KDF WE
Sbjct: 578  KQKMLSFYTMPEYEAWKESLNGETKGWTIKYYKGLGTSTSKEGKEYFRELSKHKKDFKWE 637

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             + DG AIEMAFSKKK E RK W+R++EPG + D  A +I Y DFVNKELILFS ADL R
Sbjct: 638  SEMDGDAIEMAFSKKKIEARKTWLRHYEPGTFLDMTADKIKYSDFVNKELILFSMADLAR 697

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILFC FK+    + KV QF GYVSEHSAYHHGE SLASTIIGMAQ
Sbjct: 698  SIPSMVDGLKPGQRKILFCCFKRNFVTQAKVAQFSGYVSEHSAYHHGEASLASTIIGMAQ 757

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            +FVGSNNINLL P GQFGTR  GGK+HAS RYI+T L PITR LF + DD LL+Y+ EDG
Sbjct: 758  NFVGSNNINLLSPEGQFGTREQGGKNHASPRYIFTCLAPITRALFPQPDDVLLDYMKEDG 817

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWY PIIPLVLVNGSEGIGTGWSS++PNYNPR+I+AN+RRLL  + + PM PWY+
Sbjct: 818  QSIEPSWYCPIIPLVLVNGSEGIGTGWSSFVPNYNPREIVANIRRLLAGQELTPMHPWYK 877

Query: 492  GFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
             F G IE SA K+ G  Y + GT+E+IDE + +I ELP+RKWTQDYK+FL+++   S   
Sbjct: 878  SFMGTIECSATKDIGLTYTITGTIEQIDETTIKILELPVRKWTQDYKEFLDALMTPSDKN 937

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
            K+P I+DFR++  D  V  E+ +  E +A+ + EGL+KKFKLTTTISTSNMHLFDA+G I
Sbjct: 938  KEPFIKDFREHNTDTKVHFELTLSEENMAIALAEGLVKKFKLTTTISTSNMHLFDAKGII 997

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            KKY+ PEQILEEFF +RLD Y +RK   L+N +  L+ +DNKVRFILGVV GEI+V+NRK
Sbjct: 998  KKYDTPEQILEEFFHIRLDLYVKRKAVQLQNLQYELVKVDNKVRFILGVVKGEIIVNNRK 1057

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            + DLL ELQ KGF P PKK KS +P V GA                       K  DY+Y
Sbjct: 1058 RIDLLSELQHKGFAPFPKKAKSPDPPVVGA-------DPLPEDNEQDEKVKGVKVADYDY 1110

Query: 729  LLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAE 788
            LLSM IG+LT E VQ                     +++W+            Q+ +EA 
Sbjct: 1111 LLSMPIGSLTYEKVQQLRGQRDKMEEEVEELKRATPEALWIKDLDEFLVKLDAQEEQEAI 1170

Query: 789  DEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAES 829
            D       ++K       G +  KKP   ++   K K  ES
Sbjct: 1171 DAVYEAKHSAKE------GNQTFKKPAPRKQAAPKVKKVES 1205


>A9SRT5_PHYPA (tr|A9SRT5) DNA topoisomerase 2 (Fragment) OS=Physcomitrella patens
            subsp. patens GN=PHYPADRAFT_134247 PE=3 SV=1
          Length = 1172

 Score = 1025 bits (2651), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 493/734 (67%), Positives = 584/734 (79%), Gaps = 11/734 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA  G+++ +L+WADFKQSK+LKK DG K QR+ GI KL+DANDAGG++S+KCTLILTEG
Sbjct: 399  VAKCGVVENVLTWADFKQSKELKKNDGAKRQRITGIPKLDDANDAGGKSSEKCTLILTEG 458

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAM+G+SVVGRD YGVFPLRGKLLNVREAS+KQIM+N EI NIK+ILGLQ  K+Y
Sbjct: 459  DSAKALAMSGISVVGRDKYGVFPLRGKLLNVREASHKQIMENAEITNIKRILGLQHGKDY 518

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + KSLRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLK+PSF+VEF TPI++A +  
Sbjct: 519  DSTKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATNKQ 578

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             T LSFY+MPEYE+W+E+L     GW IKYYKGLGTST +EG+EYFR+L KH+KDF WE 
Sbjct: 579  KT-LSFYTMPEYEAWKESLNGETKGWTIKYYKGLGTSTSKEGKEYFRELVKHKKDFKWES 637

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIEMAFSKKK E RK W+R++EPG + D  A +INY+DFVNKELILFS ADL RS
Sbjct: 638  EMDGDAIEMAFSKKKIEARKTWLRHYEPGTFLDMTAEKINYRDFVNKELILFSMADLARS 697

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFC FK+    + KV QF GYVSEHSAYHHGE SLASTIIGMAQ+
Sbjct: 698  IPSMVDGLKPGQRKILFCCFKRNFVTQAKVAQFSGYVSEHSAYHHGEASLASTIIGMAQN 757

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL P GQFGTR  GGK+HAS RYI+T L PITR LF + DD LL+YL EDG+
Sbjct: 758  FVGSNNINLLSPEGQFGTREQGGKNHASPRYIFTCLAPITRALFPQADDVLLDYLKEDGQ 817

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY PIIPLVLVNGSEGIGTGWSS++PNYNPR+I+AN+RRLL  + M PM PWY+G
Sbjct: 818  SIEPTWYCPIIPLVLVNGSEGIGTGWSSFVPNYNPREIVANLRRLLAGQEMEPMHPWYKG 877

Query: 493  FKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG IE SA K+ G  Y + G +++IDE + +I+ELP+RKWTQDYK+FL+ +   S   K
Sbjct: 878  FKGSIECSATKDSGFTYTITGAIDQIDETTIKISELPVRKWTQDYKEFLDVMMTPSDKNK 937

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
            +P I+DFR++  D  V  E+ +  E +A+ + EGL+KKFKLTTTISTSNMHLFD +G IK
Sbjct: 938  EPFIKDFREHNTDTKVHFELSLSEENMAIALAEGLVKKFKLTTTISTSNMHLFDNKGIIK 997

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY+ PEQILEEFF +RLD Y +RK   L+N E  L  +DNKVRFILGVV GEI+V+NRK+
Sbjct: 998  KYDTPEQILEEFFHIRLDMYVKRKAVQLQNLEYELHKVDNKVRFILGVVKGEIIVNNRKR 1057

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            ADLL +LQ+KGFTP PKK KS++P V GA                       +  DYEYL
Sbjct: 1058 ADLLADLQKKGFTPFPKKSKSSDPPVVGA-------DPLPEDDEQDEKVKGIRAADYEYL 1110

Query: 730  LSMSIGTLTLESVQ 743
            LSM IGTLT E VQ
Sbjct: 1111 LSMPIGTLTFEKVQ 1124


>D8SXJ0_SELML (tr|D8SXJ0) DNA topoisomerase 2 OS=Selaginella moellendorffii
            GN=SELMODRAFT_127267 PE=3 SV=1
          Length = 1151

 Score = 1024 bits (2647), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 485/734 (66%), Positives = 585/734 (79%), Gaps = 9/734 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V+  G++D +LSWADFKQSK+LKK DG K QRL GI KL+DANDAGG+NS+ CTLILTEG
Sbjct: 386  VSKCGVVDNVLSWADFKQSKELKKNDGAKRQRLTGIAKLDDANDAGGKNSEACTLILTEG 445

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAM+G+SVVGR+HYGVFPLRGKLLNVREA++KQIMDN EI +IK+ILGLQQ K Y
Sbjct: 446  DSAKALAMSGISVVGRNHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGY 505

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             N KSLRYGHLMIM DQDHDGSHIKGL+INFIH+FWPSLLKVP F+VEF TPI++A H N
Sbjct: 506  ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFITPIVKATHKN 565

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G  LSFY+MPEYESW+E+L     GW IKYYKGLGTST +EG+EYFRDL KH+KDF W++
Sbjct: 566  GKVLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDN 625

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG +IE+AFSKKK E RK+W+R ++PG + D     I Y DF+NKELILFS ADL RS
Sbjct: 626  DEDGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARS 685

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            +PS+VDGLKPGQRKILF +FK+    + KV QF GYVSEHSAYHHGEQSLASTIIGMAQ+
Sbjct: 686  VPSMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQN 745

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNIN+L P GQFGTR+ GGKDHAS+RYIYT L P+TR +F + DD LL +L EDG+
Sbjct: 746  FVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLREDGQ 805

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY PI+P+VLVNGSEGIGTGWS+++PNYNPRDI+ N++ LL DE + PMDPWY+G
Sbjct: 806  SIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKG 865

Query: 493  FKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG I KSA KE G  Y V G VE+++E + R+ ELPIRKWTQDYK+FLE++  G+  +K
Sbjct: 866  FKGTIVKSATKESGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALLCGTEKIK 925

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
            +P I+D+R++  D  V  EI +  EK+A  + EGL KKFKL+TTISTSNM+LFD +G I+
Sbjct: 926  EPSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTSNMNLFDKDGHIR 985

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY+ PEQILE+F+ +RL+ Y +RK+  +EN +  LL LDNKVRFILGVV GEIVV+NRK+
Sbjct: 986  KYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVVKGEIVVNNRKR 1045

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            A+LL+EL+ KGFTP PKK K+++  V G                        + GDYEYL
Sbjct: 1046 AELLVELKTKGFTPFPKKAKASDLPVVGG------DGSDVEADDEEKLNKGVRAGDYEYL 1099

Query: 730  LSMSIGTLTLESVQ 743
            LSM IGTLTLE VQ
Sbjct: 1100 LSMPIGTLTLEKVQ 1113


>M4D3L7_BRARP (tr|M4D3L7) DNA topoisomerase 2 OS=Brassica rapa subsp. pekinensis
            GN=Bra011071 PE=3 SV=1
          Length = 1412

 Score = 1023 bits (2646), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 519/828 (62%), Positives = 614/828 (74%), Gaps = 11/828 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SG+++ LLSWA FKQSKDLKK+DGTKT R++ + KLEDAN AGG+ S +CTLILTEG
Sbjct: 401  VAKSGVVENLLSWATFKQSKDLKKSDGTKTDRVQ-VEKLEDANKAGGKESQRCTLILTEG 459

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG++VVGRD+YGVFPLRGKLLNVREA+  QI +N+EI+NIKKILGL+QN  Y
Sbjct: 460  DSAKALAMAGMAVVGRDYYGVFPLRGKLLNVREATTTQITNNKEIENIKKILGLKQNMVY 519

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             NV SLRYGH+MIM DQDHDGSHIKGLLINFIHSFWP+LLKVPSF+VEF TPI++A   N
Sbjct: 520  ENVNSLRYGHMMIMTDQDHDGSHIKGLLINFIHSFWPTLLKVPSFLVEFITPIVKATRKN 579

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
               LSFYSMPEYESW+E+L  NATGW IKYYKGLGTST +EG+EYF +L  H+KDFVWED
Sbjct: 580  EV-LSFYSMPEYESWKESLSGNATGWTIKYYKGLGTSTSKEGKEYFGNLDIHKKDFVWED 638

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + DG AIE+AFSKKK E RK W+ +FEPG + D    +I++ DFVNKELILFS ADLQRS
Sbjct: 639  EQDGEAIELAFSKKKIEARKNWLSHFEPGTHLDQKQQKISFSDFVNKELILFSMADLQRS 698

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFK+   KE KV QF GYVSEHSAYHHGEQSLA TIIGMAQD
Sbjct: 699  IPSMVDGLKPGQRKILFCSFKRNFTKEAKVAQFSGYVSEHSAYHHGEQSLAGTIIGMAQD 758

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNNINLL+PNGQFGTRN+GGKD AS RYI+T+L+  TR LF ++DD LL YLNEDG+
Sbjct: 759  YVGSNNINLLQPNGQFGTRNMGGKDAASPRYIFTKLSSATRVLFPKDDDVLLNYLNEDGQ 818

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP+WY+PIIP VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLN E+MV MDPWYR 
Sbjct: 819  KIEPTWYMPIIPTVLVNGSEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMVAMDPWYRN 878

Query: 493  FKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG IEK+A KEGG  Y + G  EEIDE   R+TELPIR+W++DYKQFLE++     N  
Sbjct: 879  FKGTIEKTASKEGGSTYTITGVYEEIDETIIRVTELPIRRWSEDYKQFLEAL---KTNNN 935

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
             P  +  +   DD  VD E+ +  E + M  QEG+LK  KLTTTI+T+NMHLFD    IK
Sbjct: 936  TPYFQSVKAYNDDRSVDFELHLSEENMMMARQEGILKMLKLTTTIATTNMHLFDENNLIK 995

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY +PEQI+EEFF LRL YYE+RK+ ILEN E  LL L+NKV+FILGVVSGEI+V+NRKK
Sbjct: 996  KYASPEQIVEEFFQLRLQYYEKRKRVILENLELELLKLENKVKFILGVVSGEIIVNNRKK 1055

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            ++L+ EL QKGFTP PKKGK  E  VAGA                          +Y+YL
Sbjct: 1056 SELVQELGQKGFTPFPKKGKPVEAAVAGATDSAEEESEETSGVPGSRSTFISG-SEYDYL 1114

Query: 730  LSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAED 789
            LS++I TLTLE VQ                     +S+W              D ++AE 
Sbjct: 1115 LSLAIATLTLEKVQELCGERDKMEKAVEDMKKATPRSLWFRDLESLDAELDKLDQEDAEA 1174

Query: 790  EKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMETG 837
            EK+ I +A K+   +  G     K   PRK   K     + +S ME G
Sbjct: 1175 EKE-IEKAQKKLRAK-AGAPKGGKAAAPRKQAPKKTTKAASSSAMEIG 1220


>D8RNR7_SELML (tr|D8RNR7) DNA topoisomerase 2 OS=Selaginella moellendorffii
            GN=SELMODRAFT_98330 PE=3 SV=1
          Length = 1151

 Score = 1023 bits (2646), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 485/734 (66%), Positives = 585/734 (79%), Gaps = 9/734 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V+  G++D +LSWADFKQSK+LKK DG K QRL GI KL+DANDAGG+NS+ CTLILTEG
Sbjct: 386  VSKCGVVDNVLSWADFKQSKELKKNDGAKRQRLTGIAKLDDANDAGGKNSEACTLILTEG 445

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAM+G+SVVGR+HYGVFPLRGKLLNVREA++KQIMDN EI +IK+ILGLQQ K Y
Sbjct: 446  DSAKALAMSGISVVGRNHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGY 505

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             N KSLRYGHLMIM DQDHDGSHIKGL+INFIH+FWPSLLKVP F+VEF TPI++A H N
Sbjct: 506  ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFITPIVKATHKN 565

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G  LSFY+MPEYESW+E+L     GW IKYYKGLGTST +EG+EYFRDL KH+KDF W++
Sbjct: 566  GKVLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDN 625

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG +IE+AFSKKK E RK+W+R ++PG + D     I Y DF+NKELILFS ADL RS
Sbjct: 626  DEDGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARS 685

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            +PS+VDGLKPGQRKILF +FK+    + KV QF GYVSEHSAYHHGEQSLASTIIGMAQ+
Sbjct: 686  VPSMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQN 745

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNIN+L P GQFGTR+ GGKDHAS+RYIYT L P+TR +F + DD LL +L EDG+
Sbjct: 746  FVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLREDGQ 805

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY PI+P+VLVNGSEGIGTGWS+++PNYNPRDI+ N++ LL DE + PMDPWY+G
Sbjct: 806  SIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEPLEPMDPWYKG 865

Query: 493  FKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG I KSA KE G  Y V G VE+++E + R+ ELPIRKWTQDYK+FLE++  G+  +K
Sbjct: 866  FKGTIVKSASKESGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALLCGTEKIK 925

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
            +P I+D+R++  D  V  EI +  EK+A  + EGL KKFKL+TTISTSNM+LFD +G I+
Sbjct: 926  EPSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTSNMNLFDKDGHIR 985

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY+ PEQILE+F+ +RL+ Y +RK+  +EN +  LL LDNKVRFILGVV GEIVV+NRK+
Sbjct: 986  KYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVVKGEIVVNNRKR 1045

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            A+LL+EL+ KGFTP PKK K+++  V G                        + GDYEYL
Sbjct: 1046 AELLVELKTKGFTPFPKKAKASDLPVVGG------DGSDVEADDEEKLNKGVRAGDYEYL 1099

Query: 730  LSMSIGTLTLESVQ 743
            LSM IGTLTLE VQ
Sbjct: 1100 LSMPIGTLTLEKVQ 1113


>D8TGD2_SELML (tr|D8TGD2) DNA topoisomerase 2 (Fragment) OS=Selaginella
           moellendorffii GN=SELMODRAFT_138946 PE=3 SV=1
          Length = 980

 Score = 1023 bits (2646), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 485/734 (66%), Positives = 585/734 (79%), Gaps = 9/734 (1%)

Query: 13  VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
           V+  G++D +LSWADFKQSK+LKK DG K QRL GI KL+DANDAGG+NS+ CTLILTEG
Sbjct: 215 VSKCGVVDNVLSWADFKQSKELKKNDGAKRQRLTGIAKLDDANDAGGKNSEACTLILTEG 274

Query: 73  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
           DSAKALAM+G+SVVGR+HYGVFPLRGKLLNVREA++KQIMDN EI +IK+ILGLQQ K Y
Sbjct: 275 DSAKALAMSGISVVGRNHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGY 334

Query: 133 SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            N KSLRYGHLMIM DQDHDGSHIKGL+INFIH+FWPSLLKVP F+VEF TPI++A H N
Sbjct: 335 ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFITPIVKATHKN 394

Query: 193 GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
           G  LSFY+MPEYESW+E+L     GW IKYYKGLGTST +EG+EYFRDL KH+KDF W++
Sbjct: 395 GKVLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDN 454

Query: 253 DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
           D DG +IE+AFSKKK E RK+W+R ++PG + D     I Y DF+NKELILFS ADL RS
Sbjct: 455 DEDGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARS 514

Query: 313 IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
           +PS+VDGLKPGQRKILF +FK+    + KV QF GYVSEHSAYHHGEQSLASTIIGMAQ+
Sbjct: 515 VPSMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQN 574

Query: 373 FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
           FVGSNNIN+L P GQFGTR+ GGKDHAS+RYIYT L P+TR +F + DD LL +L EDG+
Sbjct: 575 FVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLREDGQ 634

Query: 433 SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
           SIEP WY PI+P+VLVNGSEGIGTGWS+++PNYNPRDI+ N++ LL DE + PMDPWY+G
Sbjct: 635 SIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEPLEPMDPWYKG 694

Query: 493 FKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
           FKG I KSA KE G  Y V G VE+++E + R+ ELPIRKWTQDYK+FLE++  G+  +K
Sbjct: 695 FKGTIVKSASKESGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALLCGTEKIK 754

Query: 550 DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
           +P I+D+R++  D  V  EI +  EK+A  + EGL KKFKL+TTISTSNM+LFD +G I+
Sbjct: 755 EPSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTSNMNLFDKDGHIR 814

Query: 610 KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
           KY+ PEQILE+F+ +RL+ Y +RK+  +EN +  LL LDNKVRFILGVV GEIVV+NRK+
Sbjct: 815 KYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVVKGEIVVNNRKR 874

Query: 670 ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
           A+LL+EL+ KGFTP PKK K+++  V G                        + GDYEYL
Sbjct: 875 AELLVELKTKGFTPFPKKAKASDLPVVGG------DGSDVEADDEEKLNKGVRAGDYEYL 928

Query: 730 LSMSIGTLTLESVQ 743
           LSM IGTLTLE VQ
Sbjct: 929 LSMPIGTLTLEKVQ 942


>J3LG54_ORYBR (tr|J3LG54) DNA topoisomerase 2 OS=Oryza brachyantha GN=OB02G36210
            PE=3 SV=1
          Length = 1506

 Score = 1019 bits (2636), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 511/841 (60%), Positives = 606/841 (72%), Gaps = 37/841 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V +S I+  LLSWADFK SK+L+KTDG+K  RL GI KLEDAN AGG++S  CTLILTEG
Sbjct: 405  VGSSAIVTNLLSWADFKLSKELQKTDGSKRSRLTGIPKLEDANGAGGKDSQMCTLILTEG 464

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG++VVGRD YGVFPLRGKLLNVREAS+KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 465  DSAKALAMAGIAVVGRDRYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKQY 524

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSL+K+PSF+VEF TPII+A +  
Sbjct: 525  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKR 584

Query: 193  GTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
              K  L FYSMPEYE W+E+LG NA GW IKYYKGLGTST  EGR+YF+D+ KH+KDFVW
Sbjct: 585  DKKNVLPFYSMPEYEQWKESLGGNARGWSIKYYKGLGTSTSTEGRQYFQDIAKHKKDFVW 644

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
             +D D   IE+AFSKK+  DRK W+ NF+PG Y D     I Y DF+NKELI FS ADL 
Sbjct: 645  ANDQDDDNIELAFSKKRITDRKDWLSNFQPGTYLDQHDKYIKYSDFINKELIQFSMADLL 704

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPS+VDGLKPGQRKILFCSFK+ L KE KV QF GYVSEHSAYHHGEQSLASTI GMA
Sbjct: 705  RSIPSMVDGLKPGQRKILFCSFKRNLVKETKVAQFSGYVSEHSAYHHGEQSLASTITGMA 764

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDFVGSNNINLL P GQFGTR+ GGKD AS+RYIYT+L PITR +F ++DD LL YL+ED
Sbjct: 765  QDFVGSNNINLLLPLGQFGTRDQGGKDAASARYIYTQLAPITRSIFPKDDDILLNYLDED 824

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLN+E + PMDPWY
Sbjct: 825  GQSIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNNEPVEPMDPWY 884

Query: 491  RGFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI------ 541
            RGFKG I+K++ + G   Y V G +E +D+ + RITELPIR+W+QDYK+FL SI      
Sbjct: 885  RGFKGSIQKTSTKAGGVSYTVTGIIEVLDDTTLRITELPIRRWSQDYKEFLISIGGMDKS 944

Query: 542  -------------TDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKF 588
                                 +P IE F  + DD  V+  I +  E +A+  QEGL KKF
Sbjct: 945  KDKDKGKGKGKEKEKDKDKDIEPFIEVFDTHSDDKNVEFLITLSKENMAIAKQEGLEKKF 1004

Query: 589  KLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLD 648
            KLTTTI T+NMHLFD+ GKI+KY+ PE IL+EFF LRL++YE+RK+ +LEN E  L  L 
Sbjct: 1005 KLTTTIGTTNMHLFDSNGKIRKYDTPEDILQEFFGLRLEFYEKRKRVLLENIELELKKLS 1064

Query: 649  NKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXX 708
            NKVRFIL VV G+I+V+NRK+ADL +EL+QKGF P PKK +S EP   GA          
Sbjct: 1065 NKVRFILAVVEGDIIVNNRKRADLFVELRQKGFDPFPKKIQSTEPAAVGASEEDEENEES 1124

Query: 709  XXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
                            DYEYLLSMSIGTLTLE VQ                  T  K +W
Sbjct: 1125 PETVKGVSS------SDYEYLLSMSIGTLTLEKVQELIAEKGRLENGVAELKGTTPKLLW 1178

Query: 769  MXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAE 828
            M                +  DE+ RI+ A +R STR++G   A K    R+  K   N+E
Sbjct: 1179 MRDLDEFEKQL------DVLDEEDRIN-AEERRSTRNVGHGVAPKAAARRRPKKTATNSE 1231

Query: 829  S 829
            +
Sbjct: 1232 A 1232


>B9GFC4_POPTR (tr|B9GFC4) DNA topoisomerase 2 OS=Populus trichocarpa
            GN=POPTRDRAFT_706393 PE=3 SV=1
          Length = 1468

 Score = 1019 bits (2636), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 539/857 (62%), Positives = 638/857 (74%), Gaps = 46/857 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA S I+D LLSWA FK+SK+LKKTDGTKT ++  + KLEDAN+AGGR S+KCTLILTEG
Sbjct: 380  VAKSDIVDNLLSWAKFKESKELKKTDGTKTAKV-NVPKLEDANEAGGRYSEKCTLILTEG 438

Query: 73   DSAKALAM---AGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            DSAKALA+   AGL+   R  YGVFPLRGKLLNVREA+ KQ+ +N+EI+ IKKILGLQ +
Sbjct: 439  DSAKALAVTGVAGLTQTERSFYGVFPLRGKLLNVREATPKQLKENKEIECIKKILGLQHH 498

Query: 130  KEYSNVKSLRYGHLMIMADQ-------------DHDGSHIKGLLINFIHSFWPSLLKVPS 176
            K+YSNVKSLRYGHLMIM DQ             DHDGSHIKGLLINF+HSFWPSLLKVPS
Sbjct: 499  KQYSNVKSLRYGHLMIMTDQAKERFANFLCFKQDHDGSHIKGLLINFLHSFWPSLLKVPS 558

Query: 177  FMVEFTTPIIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGRE 236
            F+VEF TPI++A H NGT LSFYSMPEYESW+ +L  NA+GW IKYYKGLGTST +EG+ 
Sbjct: 559  FLVEFITPIVKATHRNGTVLSFYSMPEYESWKGSLAGNASGWSIKYYKGLGTSTSKEGKA 618

Query: 237  YFRDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDF 296
            YF+ L KH+KDF+W D+ DG AIE+AFSKKK E RK W+R +EPG + D     I Y DF
Sbjct: 619  YFQSLDKHKKDFIWMDEQDGDAIELAFSKKKIEARKNWLRQYEPGTHLDQNQKLIKYSDF 678

Query: 297  VNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYH 356
            +NKELILFS ADLQRSIPS+VDGLKPGQRKILFCSFK+   KE K+ QF GYVSEHSAYH
Sbjct: 679  INKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAKISQFSGYVSEHSAYH 738

Query: 357  HGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLF 416
            HGEQSLASTIIGMAQDFVGSNNINLL PNGQFGTR++GGKDHAS+RYIYT+L+PITR LF
Sbjct: 739  HGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRSVGGKDHASARYIYTQLSPITRFLF 798

Query: 417  HENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRR 476
             ++DD LL+YL+EDG++IEP+WY+PIIP+VLVNG EGIGTGWS++IPNYNPRDI+AN+RR
Sbjct: 799  PKDDDGLLDYLDEDGQTIEPNWYMPIIPMVLVNGCEGIGTGWSTFIPNYNPRDIVANIRR 858

Query: 477  LLNDETMVPMDPWYRGFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQD 533
            LLN E M PM+PWYRGFKG IEK A KE G  Y VNG + E++E + RITELPIR+WT D
Sbjct: 859  LLNGEMMEPMNPWYRGFKGTIEKGASKEAGCSYTVNGVINEVNETTLRITELPIRRWTDD 918

Query: 534  YKQFLESITDGSPN-----VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKF 588
            YK FL S+T+G+ +      KDP I+DFR+ GDDA V  E+ +  E + +  QEGLLKKF
Sbjct: 919  YKAFLNSVTEGNRDENGNLPKDPFIKDFRKYGDDATVVFEVLLSEENMMIAKQEGLLKKF 978

Query: 589  KLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLD 648
            KLTTTISTSNMHLFD+ G IKKY+NPEQILEEFF LRL+YYERRK+ +LEN E  LL L+
Sbjct: 979  KLTTTISTSNMHLFDSAGVIKKYDNPEQILEEFFHLRLEYYERRKKVLLENLEFELLKLE 1038

Query: 649  NKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXX 708
            NKVRFILGVV GEI+V+NRK+ADL +EL QKGFTP+PKK K+    VAGA          
Sbjct: 1039 NKVRFILGVVRGEIIVNNRKRADLFLELHQKGFTPIPKKSKAV---VAGA-------TDD 1088

Query: 709  XXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
                         +  DY+YLLSM+IGTLTLE VQ                  T    +W
Sbjct: 1089 KDEAEDSLEVSGVRASDYDYLLSMAIGTLTLEKVQQLCADHDKLNGEVDNLRKTTPIVLW 1148

Query: 769  MXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQ-PRKNTKKTKNA 827
            +             D  +AE E+ R  +  K  +  + G K +K+ P+ PRK TKK  N 
Sbjct: 1149 VKDLEALEMQLDVLDKYDAEAEEAR--KKLKGDANGEAGFKVSKQAPKNPRKYTKKAINE 1206

Query: 828  E--------SDNSPMET 836
            E        + +S MET
Sbjct: 1207 EVSVETMGKASSSAMET 1223


>Q6Z8D9_ORYSJ (tr|Q6Z8D9) DNA topoisomerase 2 OS=Oryza sativa subsp. japonica
            GN=P0459B01.29 PE=2 SV=1
          Length = 1525

 Score = 1018 bits (2633), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 511/850 (60%), Positives = 615/850 (72%), Gaps = 45/850 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V +S I+  LLSWA+FK SK+L+KTDG+K  RL GI KLEDAN AGG++S+ CTLILTEG
Sbjct: 402  VGSSAIVLNLLSWAEFKLSKELQKTDGSKRSRLTGIPKLEDANGAGGKDSNNCTLILTEG 461

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGRD+YGVFPLRGKLLNVREAS+KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 462  DSAKALAMAGISVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKQY 521

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSL+K+PSF+VEF TPII+A +  
Sbjct: 522  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKR 581

Query: 193  GTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
              K  L FYSMPEYE W+E+LG NA+GW IKYYKGLGTST  EGR+YF+D+ KH+KDFVW
Sbjct: 582  DKKIVLPFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVW 641

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
            ++D D + IE+AFSKK+  DRK W+ NF+ G + D     I Y DF+NKELI FS ADL 
Sbjct: 642  KNDQDDNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLL 701

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPS+VDGLKPGQRKILFCSFK+ L KEIKV QF GYVSEHSAYHHGEQSLASTI GMA
Sbjct: 702  RSIPSMVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMA 761

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDFVGSNNINLL+PNGQFGTR+ GGKD AS+RYI+T L+PITR +F ++DD LL YL+ED
Sbjct: 762  QDFVGSNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDED 821

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLNDE + PMDPWY
Sbjct: 822  GQSIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWY 881

Query: 491  RGFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            RGFKG I+K+  + G   Y V G +E +D+ + RITELPIR+W+QDYK+FL SI     +
Sbjct: 882  RGFKGSIQKTGTKAGGVSYTVTGIIEVVDDTTLRITELPIRRWSQDYKEFLISIGGTDKS 941

Query: 548  VK----------------------DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLL 585
                                    +P IE F    DD  V+  I +  E +A+ +QEGL 
Sbjct: 942  KDKDKDKGKGKGKVKEKEKKEKDIEPFIEAFDTYSDDKNVEFLITLSKENMAIALQEGLE 1001

Query: 586  KKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLL 645
            KKFKLTTTI T+NMHLFD+ GKI+KY+ PE IL+EFF LRL++YE+RK+ +LEN E  L 
Sbjct: 1002 KKFKLTTTIGTTNMHLFDSNGKIRKYDTPEDILKEFFGLRLEFYEKRKRVLLENIELELK 1061

Query: 646  VLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXX 705
             L NKVRFIL VV G+I+V+NRK+A+L +EL+QKGF P P+K + A P   GA       
Sbjct: 1062 KLSNKVRFILAVVEGDIIVNNRKRAELFVELKQKGFDPFPRKKQRAGPSAVGAIEEDEEN 1121

Query: 706  XXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSK 765
                               DYEYLLSM+IGTLTLE VQ                  T  K
Sbjct: 1122 EESPEAANVGS-------SDYEYLLSMAIGTLTLERVQQLIAEKGRMENEVAELKRTRPK 1174

Query: 766  SMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAA--KKPPQ--PRKNT 821
            S+WM             D K++ D       A +R +TR+ G  AA  K  P+  PRK  
Sbjct: 1175 SLWMRDLDAFEKELDALDEKDSMD-------AEERRATRNAGGGAAPNKAAPKRRPRKTA 1227

Query: 822  KKTKNAESDN 831
              T+ AES +
Sbjct: 1228 TNTQAAESSD 1237


>R0G2R4_9BRAS (tr|R0G2R4) Uncharacterized protein OS=Capsella rubella
            GN=CARUB_v10012826mg PE=4 SV=1
          Length = 1284

 Score = 1018 bits (2631), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 511/832 (61%), Positives = 622/832 (74%), Gaps = 13/832 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG+++ LLSWADFKQSKDLKKTDG KT R+  + KL DAN+AGG+NS KCTLILTEG
Sbjct: 399  VEKSGVVENLLSWADFKQSKDLKKTDGAKTGRVF-VEKLSDANEAGGKNSQKCTLILTEG 457

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LAMAG+SVVG D+YGVFPLRGKLLNVREAS  QI +N+EI+N+KKILGL+Q+ +Y
Sbjct: 458  DSAKSLAMAGVSVVGHDYYGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQHMKY 517

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             NV SLRYGH+MIM DQDHDGSHIKGLLINFIHSFWPSLLKVPSF+VEF TPI++A +  
Sbjct: 518  ENVNSLRYGHMMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATNKK 577

Query: 193  GTK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              + LSFYSMPEYE W+E+L  NATGW+IKYYKGLGTS  +EG+EYF +L  H+KDFVWE
Sbjct: 578  TKRVLSFYSMPEYEDWKESLRGNATGWEIKYYKGLGTSDAKEGKEYFSNLSLHKKDFVWE 637

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D+ DG AIE+AFSKKK E RK W+ N+ PG + D    +I Y DFVNKELILFS ADLQR
Sbjct: 638  DEQDGEAIELAFSKKKIEARKNWLSNYVPGTHLDQKEPKITYSDFVNKELILFSMADLQR 697

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILF +FKK L KE+KV QF GYV+EHSAYHHGEQSL STIIGMAQ
Sbjct: 698  SIPSMVDGLKPGQRKILFSAFKKNLVKEMKVAQFSGYVAEHSAYHHGEQSLGSTIIGMAQ 757

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            D++GSNNINLLKP GQFGTR  GGKD AS+RYI+T L+P TR L+ ++DD LL+YLNEDG
Sbjct: 758  DYLGSNNINLLKPKGQFGTRASGGKDAASTRYIFTVLSPATRVLYPKDDDVLLDYLNEDG 817

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            + IEP+WY+PIIP VLVNGSEGIGTGWS++IPNYNPR+I+AN+RRL+N E++VPMDPWYR
Sbjct: 818  QKIEPTWYMPIIPTVLVNGSEGIGTGWSTFIPNYNPREIVANIRRLINGESVVPMDPWYR 877

Query: 492  GFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            GFKG IEKSA KEGG  Y ++G  EE+D+ + RITELPIR+WT DYKQFLES+     + 
Sbjct: 878  GFKGTIEKSASKEGGCTYTISGLYEEVDDTTIRITELPIRRWTDDYKQFLESM---KADN 934

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
              P I+D R   D A VD +I++  E +    QEG LKKFKLTTTISTSNMHLFD +G I
Sbjct: 935  GAPFIQDIRAYNDHASVDFDIKLSEENMLEARQEGFLKKFKLTTTISTSNMHLFDKKGVI 994

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            KKY +PEQILEEFF LR +YYE+RK+ +L+N E  LL L+NKV+FILGV+SGEI+V+NRK
Sbjct: 995  KKYASPEQILEEFFDLRNEYYEKRKETMLKNMELELLKLENKVKFILGVLSGEIIVNNRK 1054

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            KADL+ EL+Q+GFTP PKK    E                                +Y+Y
Sbjct: 1055 KADLVEELRQRGFTPFPKKIMPVE-AAVAGAIDAAEESEESSVDPVDSADAYIPGSEYDY 1113

Query: 729  LLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAE 788
            LL+M+IG+LT+E VQ                  T  +++W+             D  +A+
Sbjct: 1114 LLAMAIGSLTIEKVQELCEDRDKMLEAVEDLRKTTPRALWLRDLDSLDKELDKLDQADAK 1173

Query: 789  DE-KKRISQASKRTSTRD--LGTKAAKKPPQPRKNTKKTKNAE-SDNSPMET 836
             E +++++Q   R  +     G K A K P  +K TKK   +E ++ S M+T
Sbjct: 1174 AEIERKVAQEKIRAKSGAPLKGRKQAPKKPVAKKTTKKVSESETTEASAMDT 1225


>I1P3D3_ORYGL (tr|I1P3D3) DNA topoisomerase 2 OS=Oryza glaberrima PE=3 SV=1
          Length = 1524

 Score = 1010 bits (2612), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 510/849 (60%), Positives = 614/849 (72%), Gaps = 44/849 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V +S I+  LLSWA+FK SK+L+KTDG+K  RL GI KLEDAN AGG++S+ CTLILTEG
Sbjct: 402  VGSSAIVLNLLSWAEFKLSKELQKTDGSKRSRLTGIPKLEDANGAGGKDSNNCTLILTEG 461

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGRD+YGVFPLRGKLLNVREAS+KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 462  DSAKALAMAGISVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKQY 521

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSL+K+PSF+VEF TPII+A +  
Sbjct: 522  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKR 581

Query: 193  GTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
              K  L FYSMPEYE W+E+LG NA+GW IKYYKGLGTST  EGR+YF+D+ KH+KDFVW
Sbjct: 582  DKKIVLPFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVW 641

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
            ++D D + IE+AFSKK+  DRK W+ NF+ G + D     I Y DF+NKELI FS ADL 
Sbjct: 642  KNDQDDNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLL 701

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPS+VDGLKPGQRKILFCSFK+ L KEIKV QF GYVSEHSAYHHGEQSLASTI GMA
Sbjct: 702  RSIPSMVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMA 761

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDFVGSNNINLL+PNGQFGTR+ GGKD AS+RYI+T L+PITR +F ++DD LL YL+ED
Sbjct: 762  QDFVGSNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDED 821

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLNDE + PMDPWY
Sbjct: 822  GQSIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWY 881

Query: 491  RGFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            RGFKG I+K+  + G   Y V G +E +D+ + RITELPIR+W+QDYK+FL SI     +
Sbjct: 882  RGFKGSIQKTGTKAGGVSYTVTGIIEVVDDTTLRITELPIRRWSQDYKEFLISIGGTDKS 941

Query: 548  VK----------------------DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLL 585
                                    +P IE F    DD  V+  I +  E +A+ +QEGL 
Sbjct: 942  KDKDKDKGKGKGKVKEKEKKEKDIEPFIEAFDTYSDDKNVEFLITLSKENMAIALQEGLE 1001

Query: 586  KKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLL 645
            KKFKLTTTI T+NMHLFD+ GKI+KY+ PE IL+EFF LRL++YE+RK+ +LEN E  L 
Sbjct: 1002 KKFKLTTTIGTTNMHLFDSNGKIRKYDTPEDILKEFFGLRLEFYEKRKRALLENIELELK 1061

Query: 646  VLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXX 705
             L NKVRFIL VV G+I+V+NRK+A+L +EL+QKGF P P+K + A P   GA       
Sbjct: 1062 KLSNKVRFILAVVEGDIIVNNRKRAELFVELKQKGFDPFPRKKQRAGPSAVGAIEEDEEN 1121

Query: 706  XXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSK 765
                               DYEYLLSM+IGTLTLE VQ                  T  K
Sbjct: 1122 EESPEAANVGS-------SDYEYLLSMAIGTLTLERVQQLIAEKGRMENEVAELKRTRPK 1174

Query: 766  SMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPP---QPRKNTK 822
            S+WM             D K++ D       A +R +TR+ G  AA K     +PRK   
Sbjct: 1175 SLWMRDLDAFEKELDALDEKDSMD-------AEERRATRNAGGGAAPKAAPKRRPRKTAT 1227

Query: 823  KTKNAESDN 831
             T+ AES +
Sbjct: 1228 NTQAAESSD 1236


>M7Z036_TRIUA (tr|M7Z036) DNA topoisomerase 2 OS=Triticum urartu GN=TRIUR3_12968
            PE=4 SV=1
          Length = 1512

 Score = 1006 bits (2600), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 503/851 (59%), Positives = 608/851 (71%), Gaps = 46/851 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V+ SG++  LLSWA+FK +K+LKKTDGTK   + GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 401  VSGSGVVSNLLSWAEFKLNKELKKTDGTKKTSIVGIPKLEDANDAGGKNSDKCTLILTEG 460

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+ VVGRDHYGVFPLRGKLLNVREAS+KQ+M+N EIQNIKKILGLQ  K+Y
Sbjct: 461  DSAKALAMAGIGVVGRDHYGVFPLRGKLLNVREASHKQLMENAEIQNIKKILGLQHEKKY 520

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIH  WPSLLKVPSF+VEF TPII+A    
Sbjct: 521  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGK 580

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K +FYSMP+YE+W+E+LG NA+ W IKYYKGLGTST QEGR+YF D+  H+KDFVW D
Sbjct: 581  AVK-AFYSMPDYEAWKESLGGNASSWTIKYYKGLGTSTAQEGRDYFEDITHHKKDFVWAD 639

Query: 253  DY-DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D  DG AIE+AFSKKK  +RK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 640  DKEDGEAIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 699

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDG KPGQRKILFCSFKK L KE KV QFIGYVSEHSAYHHGEQSLASTIIGMAQ
Sbjct: 700  SIPSMVDGFKPGQRKILFCSFKKNLVKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQ 759

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL+P GQFGTRN GGKD AS+RYI+T L PITR +F ++DD LL YLNEDG
Sbjct: 760  DFVGSNNINLLEPRGQFGTRNAGGKDAASARYIFTRLQPITRLIFPKDDDVLLNYLNEDG 819

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWY+PIIP+VLVNGSEGIGTGWS+Y+PNYNPRDIIAN++RLLN+ET+VPM PWYR
Sbjct: 820  QSIEPSWYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNNETIVPMVPWYR 879

Query: 492  GFKGII-EKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT------ 542
            GFKG + E S+K  G  Y + G +EE+ +   +ITELP+R+WT DYK+FLES+       
Sbjct: 880  GFKGSLKETSSKATGVTYTITGVIEEVADTRLKITELPVRRWTTDYKEFLESMCPIPIKE 939

Query: 543  ---------------------DGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQ 581
                                 +   + + PL+E+ R   D A VD E+ +  + + +  Q
Sbjct: 940  KEKSKDKNKDKKKEKDKDKEKEKEKSKEPPLLEEIRSQCDHADVDFELILTEQNMNIAKQ 999

Query: 582  EGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFE 641
            EGL KKFKLTTTI T+NMHLFD+ GKI+KY+ PE +L+EFF LRLD+Y RRK+ +LEN  
Sbjct: 1000 EGLEKKFKLTTTIGTTNMHLFDSNGKIRKYDTPEDVLKEFFDLRLDFYVRRKKVMLENMG 1059

Query: 642  RLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXX 701
              LL   NKVRFIL V+SG+I+V+NRK+A+L +EL+QK + P PKK  +AEP   G+   
Sbjct: 1060 IELLKYKNKVRFILAVISGDIIVNNRKRAELFLELKQKKYDPFPKKKPTAEPVAVGSTEV 1119

Query: 702  XXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXA 761
                                   DYEYLL+MSIGTLT+E V+                  
Sbjct: 1120 DEENDEGPVEAAA---------SDYEYLLAMSIGTLTMEKVKELIAQQDKVEEDLNILSN 1170

Query: 762  TPSKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNT 821
            T   ++W+             D K   ++  R   + KR         A K+  QP+K  
Sbjct: 1171 TEPNTLWLGDLDALEKELDVLDAKLEAEQNDR---SRKRAKNAKESNAAPKR--QPKKAA 1225

Query: 822  KKTKNAESDNS 832
             K++  +S+ +
Sbjct: 1226 AKSQKVQSNTT 1236


>N1QSK5_AEGTA (tr|N1QSK5) DNA topoisomerase 2 OS=Aegilops tauschii GN=F775_01510
            PE=4 SV=1
          Length = 1471

 Score = 1002 bits (2591), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 506/859 (58%), Positives = 609/859 (70%), Gaps = 46/859 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V++SG++  LLSWA+FK +K+LKKTDGTK   + GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 333  VSSSGVVSNLLSWAEFKLNKELKKTDGTKKTSIVGIPKLEDANDAGGKNSDKCTLILTEG 392

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+ VVGRDHYGVFPLRGKLLNVREAS+KQ+M+N EIQNIKKILGLQ  K+Y
Sbjct: 393  DSAKALAMAGIGVVGRDHYGVFPLRGKLLNVREASHKQLMENAEIQNIKKILGLQHEKKY 452

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIH  WPSLLKVPSF+VEF TPII+A    
Sbjct: 453  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGK 512

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K SFYSMP+YE+W+E+LG +A+ W IKYYKGLGTST QEGR+YF D+  H+KDFVW D
Sbjct: 513  AVK-SFYSMPDYEAWKESLGGSASSWTIKYYKGLGTSTAQEGRDYFEDITHHKKDFVWAD 571

Query: 253  DY-DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D  DG AIE+AFSKKK  +RK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 572  DKEDGEAIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 631

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDG KPGQRKILFCSFKK L KE KV QFIGYVSEHSAYHHGEQSLASTIIGMAQ
Sbjct: 632  SIPSMVDGFKPGQRKILFCSFKKNLVKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQ 691

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL+P GQFGTRN GGKD AS+RYI+T L PITR +F ++DD LL YLNEDG
Sbjct: 692  DFVGSNNINLLEPRGQFGTRNAGGKDAASARYIFTRLQPITRLIFPKDDDVLLNYLNEDG 751

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWY+PIIP+VLVNGSEGIGTGWS+Y+PNYNPRDIIAN++RLLN+ET+VPM PWYR
Sbjct: 752  QSIEPSWYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNNETIVPMVPWYR 811

Query: 492  GFKGII-EKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT------ 542
            GFKG + E S+K  G  Y + G +EE+ +   +ITELP+R+WT DYK+FLES+       
Sbjct: 812  GFKGSLKETSSKATGVTYTITGVIEEVPDTRLKITELPVRRWTTDYKEFLESMCPIPIKE 871

Query: 543  -------------------DGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEG 583
                               +   + + PL+E+ R   D A VD E+ +  + + +  QEG
Sbjct: 872  KEKSKDKNKEKKKDKDKEKEKEKSKEPPLLEEIRSQCDHADVDFELILTEQNMNIAKQEG 931

Query: 584  LLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERL 643
            L KKFKLTTTI T+NMHLFD+ GKI+KY+ PE +L+EFF LRLD+Y RRK+ +LEN    
Sbjct: 932  LEKKFKLTTTIGTTNMHLFDSNGKIRKYDTPEDVLKEFFDLRLDFYVRRKKVMLENMGIE 991

Query: 644  LLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXX 703
            LL   NKVRFIL V+SG+I+V+NRK+A+L  EL+QK + P PKK  +AEP   G+     
Sbjct: 992  LLKYKNKVRFILAVISGDIIVNNRKRAELFQELKQKKYDPFPKKKPTAEPVAVGSTEVDE 1051

Query: 704  XXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATP 763
                                 DYEYLL+MSIGTLT+E V+                  T 
Sbjct: 1052 ENDESPAEAAA---------SDYEYLLAMSIGTLTMEKVKELIAQQDKVEEDLNILSNTE 1102

Query: 764  SKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKK 823
              ++W+             D K   ++  R   + KR         A K+ P+      +
Sbjct: 1103 PNTLWLRDLDALEKELDVLDAKLEAEQNDR---SRKRAKNAKESNAAPKRQPKKAAAKSQ 1159

Query: 824  TKN-AESDNSPMETGKPPH 841
              N A SD+   E   PP+
Sbjct: 1160 KANLAGSDDEDFE---PPN 1175


>M8BEA6_AEGTA (tr|M8BEA6) Uncharacterized protein OS=Aegilops tauschii
            GN=F775_52511 PE=4 SV=1
          Length = 1498

 Score = 1000 bits (2586), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 499/850 (58%), Positives = 607/850 (71%), Gaps = 43/850 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V++SG++  LLSWA+FK SK+LKKTDGTK   + GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 409  VSSSGVVTNLLSWAEFKLSKELKKTDGTKKTSIVGIPKLEDANDAGGKNSDKCTLILTEG 468

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+ VVGRDHYGVFPLRGKLLNVREAS+KQ+M+N EIQNIKKILGLQ  K+Y
Sbjct: 469  DSAKALAMAGIGVVGRDHYGVFPLRGKLLNVREASHKQLMENAEIQNIKKILGLQHEKKY 528

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIH  WPSLLKVPSF+VEF TPII+A    
Sbjct: 529  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGK 588

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K  FYSMP+YE+W+E+LG +A+ W IKYYKGLGTST +EGR+YF  +  H+KDFVW D
Sbjct: 589  SVK-PFYSMPDYEAWKEDLGASASSWTIKYYKGLGTSTAEEGRDYFEHIALHKKDFVWAD 647

Query: 253  DY-DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D  DG AIE+AFSKKK  +RK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 648  DKEDGEAIELAFSKKKISERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 707

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDG KPGQRKILFCSFKK L KE KV QFIGYVSEHSAYHHGEQSLASTIIGMAQ
Sbjct: 708  SIPSMVDGFKPGQRKILFCSFKKNLVKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQ 767

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL+P GQFGTRN GGKD AS+RYI+T L P+TR +F ++DD LL YLNEDG
Sbjct: 768  DFVGSNNINLLEPRGQFGTRNAGGKDAASARYIFTRLQPVTRLIFPKDDDVLLNYLNEDG 827

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWY+PIIP+VLVNGSEGIGTGWS+Y+PNYNP+DIIAN++RLLN ET+VPM PWYR
Sbjct: 828  QSIEPSWYMPIIPMVLVNGSEGIGTGWSTYVPNYNPKDIIANLKRLLNGETIVPMVPWYR 887

Query: 492  GFKGII-EKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT------ 542
            GFKG + E S+K  G  Y + G +EE+ +   +ITELP+R+WT DYK+FLES+       
Sbjct: 888  GFKGSLKETSSKATGVTYTITGVIEEVADTKLKITELPVRRWTTDYKEFLESMCPIPIKE 947

Query: 543  ---------------------DGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQ 581
                                 +   + + PL+E+ R   D A V+ E+ +  + + +  Q
Sbjct: 948  KEKSKDKNKEKKKDKDKDKDKEKEKSKEPPLLEEIRSQCDHADVEFELILTEQNMNIAKQ 1007

Query: 582  EGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFE 641
            EGL KKFKLTTTI T+NMHLFD+ GKIKKY+ PE +L+EFF LR ++Y +RK+ +LEN  
Sbjct: 1008 EGLEKKFKLTTTIGTTNMHLFDSHGKIKKYDTPEDVLQEFFDLRFEFYVKRKKVMLENMG 1067

Query: 642  RLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXX 701
              LL   NKVRFIL V+SG+I+V+NRK+ADL  EL+Q+G+ P PKK  ++ P   G+   
Sbjct: 1068 NELLKYQNKVRFILAVISGKIIVNNRKRADLFQELKQQGYKPFPKKKPTSGPVAVGSTEA 1127

Query: 702  XXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXA 761
                                   DYEYLL+MSIGTLT+E V+                  
Sbjct: 1128 DEDNDESPAEAAA---------SDYEYLLAMSIGTLTMEKVKELIAQQDKVEADLEILRN 1178

Query: 762  TPSKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNT 821
            T  K++W+             D K   ++  R  + +K +        A KK  QP+K T
Sbjct: 1179 TEPKTLWLRDLDALEKELDVLDAKLEAEQNDRSRKRAKNSEKAKDPKPATKK--QPKKAT 1236

Query: 822  KKTKNAESDN 831
             K++ A SD+
Sbjct: 1237 AKSQKAGSDD 1246


>Q4JF74_SCUBA (tr|Q4JF74) DNA topoisomerase 2 OS=Scutellaria baicalensis GN=TopII
            PE=2 SV=1
          Length = 1469

 Score =  999 bits (2583), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 499/831 (60%), Positives = 603/831 (72%), Gaps = 14/831 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA S I+  +  WA+FKQ KDLKKTDG+K +R+ G+ KL DAN+AGGRNSDKCTLILTEG
Sbjct: 406  VAKSDIMKNIEEWAEFKQKKDLKKTDGSKDRRIYGLAKLSDANEAGGRNSDKCTLILTEG 465

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGLSVVGRDHYGVFPLRGKLLNVREAS+ Q+M N EIQ+IK+ILGLQ  K+Y
Sbjct: 466  DSAKALAIAGLSVVGRDHYGVFPLRGKLLNVREASHNQLMHNLEIQHIKQILGLQHGKQY 525

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +VK LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLK+PSF++ F TPI++A H +
Sbjct: 526  ESVKPLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLLGFITPIVKARHKD 585

Query: 193  GT-KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            G  KLSFY+MP+YE+W+E  G  A  W +KYYKGLGTST QE  EYF DLGKH KDFV+ 
Sbjct: 586  GKRKLSFYTMPQYEAWKEAQGTEAKNWTVKYYKGLGTSTDQEAMEYFSDLGKHEKDFVYV 645

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D  D  AIE+AFSKKK E RK W+R FEPG + D   S I Y+DFV+KELILFS AD+QR
Sbjct: 646  DGEDDDAIELAFSKKKIEARKGWLRQFEPGTFLDDRDSHIKYRDFVHKELILFSIADVQR 705

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILFCSFK+   +E KV QF GYVSEHSAYHHGEQSLA TIIGMAQ
Sbjct: 706  SIPSMVDGLKPGQRKILFCSFKRNFVREAKVAQFSGYVSEHSAYHHGEQSLAGTIIGMAQ 765

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            D+VGSNNINLL P GQFGTR  GGKDHAS+RY++T+L+P+TR LF + DD LL+YLNEDG
Sbjct: 766  DYVGSNNINLLLPIGQFGTRGQGGKDHASARYVFTQLSPVTRFLFPKADDILLDYLNEDG 825

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEP+WY+PIIP+VLVNGSEGIGTGWSSY+PNYNP DIIAN+R LLNDE   PM PWY+
Sbjct: 826  QSIEPTWYVPIIPMVLVNGSEGIGTGWSSYVPNYNPVDIIANIRHLLNDEATEPMHPWYK 885

Query: 492  GFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            GF G +EK+A KE G  Y V+G +EE+D+ +  I ELPIR+WTQDYK+FLES++  +   
Sbjct: 886  GFLGSVEKTATKEAGASYTVSGIIEEVDDTTLCIKELPIRRWTQDYKEFLESVSAENDKS 945

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
            KDP IE  R      +V+  + MK EK+    +EGLLKKFKLTT+IST NMHLFD++G I
Sbjct: 946  KDPFIEGCRDYSGSELVNFLVGMKPEKLEAAKREGLLKKFKLTTSISTCNMHLFDSKGVI 1005

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            KKY+ PEQILEEFF +RL+ YE+RK+ +L+  E  +L  DNK RFI  VV G I+VSNRK
Sbjct: 1006 KKYDTPEQILEEFFYIRLELYEKRKKVLLDILEHDMLKCDNKYRFIRCVVEGSIIVSNRK 1065

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            + D+  EL++KGFTP PKK   AE  +AGA                          DY+Y
Sbjct: 1066 RTDVFRELKEKGFTPFPKKKNRAEVAIAGATDDGEETEENSEVPIAPGVSS----SDYDY 1121

Query: 729  LLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAE 788
            LLS++IGTLT E +Q                  + ++S+W             +     E
Sbjct: 1122 LLSLAIGTLTTEKMQELRAERDKLMQEVEELKQSTARSLWNKDLDALEDKLAEEQKIYEE 1181

Query: 789  DEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAE---SDNSPMET 836
              +K   +   +T T ++     K P + +K TKK    E   S+N+  ET
Sbjct: 1182 TWEKNKRKIHGKTDTLEI---IQKNPRKNKKTTKKESAVEMEISENTTTET 1229


>C5Y0E7_SORBI (tr|C5Y0E7) DNA topoisomerase 2 OS=Sorghum bicolor GN=Sb04g030880
            PE=3 SV=1
          Length = 1452

 Score =  999 bits (2582), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 505/834 (60%), Positives = 605/834 (72%), Gaps = 17/834 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  S I++ +LSWADFK SK+LKKTDG+K  R+ GI KLEDAN+AGG++S+KCTLILTEG
Sbjct: 393  VEKSSIIENVLSWADFKLSKELKKTDGSKKSRISGIPKLEDANEAGGKDSEKCTLILTEG 452

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAM+G++VVGRD+YGVFPLRGKLLNVREA++KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 453  DSAKALAMSGIAVVGRDYYGVFPLRGKLLNVREANHKQIMENAEIQNIKQILGLQHGKQY 512

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLKV SF+VEF TPII+A    
Sbjct: 513  ASAKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVESFLVEFVTPIIKATRGK 572

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             T +SFY+MPEYE WR NLG +A+ W IKYYKGLGTST +EGREYF+D+  H+KDFVWED
Sbjct: 573  -TTISFYTMPEYEEWRTNLGASASSWTIKYYKGLGTSTAKEGREYFKDITDHKKDFVWED 631

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG+ IE+AFSKK+  DRK+W+ NF+PG Y D    R+ Y DF+NKELILFS ADLQRS
Sbjct: 632  DQDGNHIELAFSKKRIADRKLWLTNFQPGTYIDQQEKRVRYSDFINKELILFSMADLQRS 691

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFK+   KE KV QF GYVSEHSAYHHGEQSLASTIIGMAQ+
Sbjct: 692  IPSMVDGLKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQN 751

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINL+ P GQFGTR  GGKD AS RYI+T+L+ ITR +F ++DD LL YLNEDG+
Sbjct: 752  FVGSNNINLMFPGGQFGTRAQGGKDAASPRYIFTKLSHITRSIFPKDDDILLNYLNEDGQ 811

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLN+E+ VPM PWYRG
Sbjct: 812  SIEPTWYMPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNEESTVPMHPWYRG 871

Query: 493  FKGIIEKSAKE----GGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            FKG IEK+         Y V G +E +D    RITELPIR+WT DYK+FLES+       
Sbjct: 872  FKGSIEKTVNTKVVGSTYTVTGIIEVVDNSRLRITELPIRRWTGDYKEFLESLGPDKNKD 931

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
            K P IED    GD+  + IEI++    + +  +EGL+KKFKLTTTI TSNMHLFD+ GKI
Sbjct: 932  KVPFIEDVTAQGDNEDIYIEIQLSEGNMNIAKEEGLVKKFKLTTTIGTSNMHLFDSNGKI 991

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            +KY+ PEQILEEFF LRL++Y +RK+ +L+N +  L  L+NKVRFI  VV  EI+V+NRK
Sbjct: 992  RKYDTPEQILEEFFQLRLEFYVKRKEALLKNIKLELKKLENKVRFIRCVVDNEIIVNNRK 1051

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            +ADL +EL+QK F P PKK K AEP  AGA                       +  DYEY
Sbjct: 1052 RADLFLELRQKNFDPFPKKKKRAEPAAAGA---------LEEENEENPEAEAAEPSDYEY 1102

Query: 729  LLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXX---XXXQDGK 785
            LL+M IGTLTLE +Q                  T  KS+W+                D  
Sbjct: 1103 LLAMPIGTLTLEKIQELIAEKQKLVDDVEELKNTSPKSLWLKDLDAFEKELDLLDQMDLS 1162

Query: 786  EAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMETGKP 839
            E E  +KRI    K  S      +   K    +   KK K+   D+   E   P
Sbjct: 1163 EEEQREKRIKDGKKGRSKAAPKKQQRGKKAGSKAAVKKEKSDTEDDDAAEPVVP 1216


>B9RVN3_RICCO (tr|B9RVN3) DNA topoisomerase II, putative OS=Ricinus communis
           GN=RCOM_0966810 PE=4 SV=1
          Length = 1212

 Score =  998 bits (2581), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 514/844 (60%), Positives = 617/844 (73%), Gaps = 29/844 (3%)

Query: 13  VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
           VA S IL+ LLSWA FK  K+LKKTDGTK  R+  I KLEDAN+AG +NS KCTLILTEG
Sbjct: 111 VAKSDILENLLSWAKFKNDKELKKTDGTKRGRV-NIPKLEDANEAGTKNSHKCTLILTEG 169

Query: 73  DSAKALAMAGLSVVG---RDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
           DSAK LA++GL  +    RD YGVFPLRGKLLNVREA+ KQ+ +N+EI++IKKILGLQQN
Sbjct: 170 DSAKTLAISGLGALPQDVRDLYGVFPLRGKLLNVREATPKQLNENKEIESIKKILGLQQN 229

Query: 130 KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
           K+Y +VK LRYGHLMIM DQD+DGSHIKGLLINFI+ FWPSLLK+PSF+VEF TPI++A 
Sbjct: 230 KQYDSVKPLRYGHLMIMTDQDYDGSHIKGLLINFIYYFWPSLLKIPSFLVEFITPIVKAT 289

Query: 190 HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
           H +G  LSFY+MPEY SW+E+L  NA GW IKYYKGLGT+  +EG +YFRD+ KH+KDFV
Sbjct: 290 HRSGKILSFYTMPEYYSWKESLMGNANGWTIKYYKGLGTNDKKEGMQYFRDIDKHQKDFV 349

Query: 250 WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
           W ++ DG+AIE+AFSKKK ++RK W+R+F+PG + +     I Y DF+NKELILFS ADL
Sbjct: 350 WMNEEDGTAIELAFSKKKVDERKNWLRHFQPGTHLEQKNKLIKYSDFINKELILFSVADL 409

Query: 310 QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
           QRSIPS+VDGLKP QRKILF  FK+ L K++KV Q  GYVSE SAYHHGEQSL STI+GM
Sbjct: 410 QRSIPSMVDGLKPAQRKILFSCFKRNLVKDLKVVQLQGYVSEQSAYHHGEQSLQSTIVGM 469

Query: 370 AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
           AQ+FVGSNNINLL P GQFGTR  GGKDHAS RYIYT L+PITR LF ++DD LL+YL E
Sbjct: 470 AQNFVGSNNINLLAPKGQFGTRCSGGKDHASPRYIYTCLSPITRFLFPKDDDCLLDYLQE 529

Query: 430 DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
           DG SIEP+WY PIIPLVLVNG EGIGTGWS++IPNYNPRDI+AN+RR LN E M PM PW
Sbjct: 530 DGLSIEPTWYAPIIPLVLVNGCEGIGTGWSTFIPNYNPRDIVANLRRFLNGEKMEPMHPW 589

Query: 490 YRGFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFL----ESIT 542
           Y+GFKG IEKSA KEGG  Y VNG +EE++E + RITELPIR+WT +YK FL    E++ 
Sbjct: 590 YKGFKGTIEKSASKEGGGSYAVNGIIEEVNETTVRITELPIRRWTDEYKDFLNSVIENVR 649

Query: 543 DGSPNV-KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHL 601
           D   N+ KD  I+DFR+ GDD  V  E+ +  EK+  +  EGLLKKFKL TTISTSNMHL
Sbjct: 650 DEKGNLPKDAFIKDFRKYGDDVSVCFEVLLSEEKMKQVKDEGLLKKFKLATTISTSNMHL 709

Query: 602 FDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGE 661
           FD +G IKKY++PE+ILEEF  LR + YE+RK + L + E   L+L+NKVRFILGVV+GE
Sbjct: 710 FDPKGVIKKYDSPEEILEEFVHLRFELYEKRKNFKLASLEMEALILENKVRFILGVVTGE 769

Query: 662 IVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXX 721
           I+V+NRK+A+LL+EL+QKGFTP P K K  E  VAGA                       
Sbjct: 770 IIVNNRKRAELLLELRQKGFTPFP-KNKPVEAVVAGA--ADDTEESESTEDVEENSKTGV 826

Query: 722 KRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXX 781
           +  DYEYLLSMSIGTLTLE VQ                  T  K +W+            
Sbjct: 827 QATDYEYLLSMSIGTLTLEKVQKLCADKDKISEEVENLRRTAPKDLWLKDLEAFESQL-- 884

Query: 782 QDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQ-PRKNTKKTKNAE--------SDNS 832
            D  +AED  +R  Q S + +    G K +++PP+ PRKN K  KN E        + NS
Sbjct: 885 -DKLDAEDALER--QKSVKDTNGQGGFKVSRQPPKNPRKNNKTAKNTEAAAEIMGQTSNS 941

Query: 833 PMET 836
            MET
Sbjct: 942 AMET 945


>I1ICW7_BRADI (tr|I1ICW7) DNA topoisomerase 2 OS=Brachypodium distachyon
            GN=BRADI3G52470 PE=3 SV=1
          Length = 1490

 Score =  998 bits (2581), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 498/847 (58%), Positives = 608/847 (71%), Gaps = 42/847 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA+SG++  LLSWADFK SK+LKKTDG+K   + GI KLEDANDAGGR+SDKCTLILTEG
Sbjct: 399  VADSGVVSNLLSWADFKLSKELKKTDGSKRSNVLGIPKLEDANDAGGRDSDKCTLILTEG 458

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG  +VG DHYGVFPLRGKLLNVREA++KQ+M+N EIQNIKKI+GLQ  KEY
Sbjct: 459  DSAKALAMAGRGIVGNDHYGVFPLRGKLLNVREATHKQMMENAEIQNIKKIIGLQHGKEY 518

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINFIHS WPSLLKVPSF+VEF TPII+A +  
Sbjct: 519  NSTKDLRYGHLMIMTDQDHDGSHIKGLLINFIHSSWPSLLKVPSFLVEFITPIIKATNKR 578

Query: 193  G-TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              + +SFYSMP+YE+W+E LG NA+ W IKYYKGLGTST  EGREYF  +  HRKDFVW 
Sbjct: 579  SKSVISFYSMPDYEAWKERLGANASAWSIKYYKGLGTSTADEGREYFEKIAHHRKDFVWA 638

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            DD DG AIE+AFSKK+  DRK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 639  DDKDGDAIELAFSKKRIADRKDWLSNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 698

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILF SFK+ L KEIKV QFIGYVSEHSAYHHGEQSLASTI+GMAQ
Sbjct: 699  SIPSMVDGLKPGQRKILFSSFKRNLVKEIKVAQFIGYVSEHSAYHHGEQSLASTILGMAQ 758

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            D+VGSNNI+LL+P GQFGTRN GGKD AS+RYIYT L  ITR +F ++DD LL YLNEDG
Sbjct: 759  DYVGSNNISLLEPRGQFGTRNSGGKDAASARYIYTRLPSITRIIFPKDDDVLLNYLNEDG 818

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEP+WY+PIIP+VLVNGSEGIGTGWS+Y PNYNPRDI+AN++RLLND+ +VPMDPWY+
Sbjct: 819  QSIEPTWYMPIIPMVLVNGSEGIGTGWSTYTPNYNPRDIVANLKRLLNDDPIVPMDPWYK 878

Query: 492  GFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS--- 545
            GFKG  EK+  +     Y ++G +E  ++    I+ELP+R+WT DYK+FL S+   S   
Sbjct: 879  GFKGSFEKTTTKAAGVTYTISGIIEAANDTKLIISELPVRRWTLDYKEFLLSMCPQSVKE 938

Query: 546  ----------------------PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEG 583
                                     + P +ED R   DD+ V  E+ +  + +A+ MQEG
Sbjct: 939  KEKEKDKNKNKSKDKDKDKDKNKEKEPPFLEDLRSQCDDSSVYFELTLSEKNMAIAMQEG 998

Query: 584  LLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERL 643
            L KKFKLT T+ T+NMHLFD+ GKI+KY+ PE+IL+EFF LRL++Y RRK  +L+N    
Sbjct: 999  LEKKFKLTNTMGTTNMHLFDSNGKIRKYDTPEEILQEFFTLRLEFYGRRKITMLKNMRVE 1058

Query: 644  LLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXX 703
            LL L+N+VRFI  V+SG+I V+NRK+A+L +EL++K F   PKK    EP   GA     
Sbjct: 1059 LLKLENRVRFIRSVISGDIKVNNRKRAELFLELKEKNFDAFPKKKNKTEPVAVGAEEEDE 1118

Query: 704  XXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATP 763
                                GDYEYLLSM+IGTLTLE V+                  T 
Sbjct: 1119 ENEESPAEDTDGVLG-----GDYEYLLSMAIGTLTLEKVKQLIAQKDNLVNEVERLSKTD 1173

Query: 764  SKSMWMXXXXXXXXXXXXQDGK-EAEDEKKRISQASKRTSTRDLGTKAAKKPP--QPRKN 820
             KS+W+             D + +A +EK+R+   ++  ST+D   KA+K  P  QP+K 
Sbjct: 1174 PKSLWVKDLDALEKELDVLDAELKAAEEKRRL---AREKSTKD--GKASKAAPKRQPKKT 1228

Query: 821  TKKTKNA 827
              K++ A
Sbjct: 1229 AAKSQKA 1235


>I1ICW6_BRADI (tr|I1ICW6) DNA topoisomerase 2 OS=Brachypodium distachyon
            GN=BRADI3G52470 PE=3 SV=1
          Length = 1494

 Score =  998 bits (2579), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 498/847 (58%), Positives = 608/847 (71%), Gaps = 42/847 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA+SG++  LLSWADFK SK+LKKTDG+K   + GI KLEDANDAGGR+SDKCTLILTEG
Sbjct: 399  VADSGVVSNLLSWADFKLSKELKKTDGSKRSNVLGIPKLEDANDAGGRDSDKCTLILTEG 458

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG  +VG DHYGVFPLRGKLLNVREA++KQ+M+N EIQNIKKI+GLQ  KEY
Sbjct: 459  DSAKALAMAGRGIVGNDHYGVFPLRGKLLNVREATHKQMMENAEIQNIKKIIGLQHGKEY 518

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINFIHS WPSLLKVPSF+VEF TPII+A +  
Sbjct: 519  NSTKDLRYGHLMIMTDQDHDGSHIKGLLINFIHSSWPSLLKVPSFLVEFITPIIKATNKR 578

Query: 193  G-TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              + +SFYSMP+YE+W+E LG NA+ W IKYYKGLGTST  EGREYF  +  HRKDFVW 
Sbjct: 579  SKSVISFYSMPDYEAWKERLGANASAWSIKYYKGLGTSTADEGREYFEKIAHHRKDFVWA 638

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            DD DG AIE+AFSKK+  DRK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 639  DDKDGDAIELAFSKKRIADRKDWLSNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 698

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILF SFK+ L KEIKV QFIGYVSEHSAYHHGEQSLASTI+GMAQ
Sbjct: 699  SIPSMVDGLKPGQRKILFSSFKRNLVKEIKVAQFIGYVSEHSAYHHGEQSLASTILGMAQ 758

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            D+VGSNNI+LL+P GQFGTRN GGKD AS+RYIYT L  ITR +F ++DD LL YLNEDG
Sbjct: 759  DYVGSNNISLLEPRGQFGTRNSGGKDAASARYIYTRLPSITRIIFPKDDDVLLNYLNEDG 818

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEP+WY+PIIP+VLVNGSEGIGTGWS+Y PNYNPRDI+AN++RLLND+ +VPMDPWY+
Sbjct: 819  QSIEPTWYMPIIPMVLVNGSEGIGTGWSTYTPNYNPRDIVANLKRLLNDDPIVPMDPWYK 878

Query: 492  GFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS--- 545
            GFKG  EK+  +     Y ++G +E  ++    I+ELP+R+WT DYK+FL S+   S   
Sbjct: 879  GFKGSFEKTTTKAAGVTYTISGIIEAANDTKLIISELPVRRWTLDYKEFLLSMCPQSVKE 938

Query: 546  ----------------------PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEG 583
                                     + P +ED R   DD+ V  E+ +  + +A+ MQEG
Sbjct: 939  KEKEKDKNKNKSKDKDKDKDKNKEKEPPFLEDLRSQCDDSSVYFELTLSEKNMAIAMQEG 998

Query: 584  LLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERL 643
            L KKFKLT T+ T+NMHLFD+ GKI+KY+ PE+IL+EFF LRL++Y RRK  +L+N    
Sbjct: 999  LEKKFKLTNTMGTTNMHLFDSNGKIRKYDTPEEILQEFFTLRLEFYGRRKITMLKNMRVE 1058

Query: 644  LLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXX 703
            LL L+N+VRFI  V+SG+I V+NRK+A+L +EL++K F   PKK    EP   GA     
Sbjct: 1059 LLKLENRVRFIRSVISGDIKVNNRKRAELFLELKEKNFDAFPKKKNKTEPVAVGAEEEDE 1118

Query: 704  XXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATP 763
                                GDYEYLLSM+IGTLTLE V+                  T 
Sbjct: 1119 ENEESPAEDTDGVLG-----GDYEYLLSMAIGTLTLEKVKQLIAQKDNLVNEVERLSKTD 1173

Query: 764  SKSMWMXXXXXXXXXXXXQDGK-EAEDEKKRISQASKRTSTRDLGTKAAKKPP--QPRKN 820
             KS+W+             D + +A +EK+R+   ++  ST+D   KA+K  P  QP+K 
Sbjct: 1174 PKSLWVKDLDALEKELDVLDAELKAAEEKRRL---AREKSTKD--GKASKAAPKRQPKKT 1228

Query: 821  TKKTKNA 827
              K++ A
Sbjct: 1229 AAKSQKA 1235


>K3YP99_SETIT (tr|K3YP99) DNA topoisomerase 2 OS=Setaria italica GN=Si016091m.g
            PE=3 SV=1
          Length = 1480

 Score =  996 bits (2576), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 504/826 (61%), Positives = 608/826 (73%), Gaps = 20/826 (2%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             V  S I+  +LSWADFK SK+LKKTDG+K  R+ GI KLEDAN+AGG++S+KCTLILTE
Sbjct: 392  GVEKSSIVSNVLSWADFKLSKELKKTDGSKKSRISGIPKLEDANEAGGKDSNKCTLILTE 451

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAKALAMAG++VVGRDHYGVFPLRGKLLNVREA++KQI+DN EIQNIK+ILGLQ  K+
Sbjct: 452  GDSAKALAMAGIAVVGRDHYGVFPLRGKLLNVREANHKQILDNTEIQNIKQILGLQHGKQ 511

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y + K LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLKVPSF+VEF TPII+A   
Sbjct: 512  YDSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIIKATKK 571

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            N TK SFY+MPEYE W+ NLG +A+ W IKYYKGLGTST +EG++YF ++ +H+KDFVW 
Sbjct: 572  NETK-SFYTMPEYEDWKRNLGASASSWTIKYYKGLGTSTSKEGKDYFTNIDQHKKDFVWV 630

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            DD DG+ IE+AFSKK+  DRK W+ NF+PG Y D     I Y+DF+NKELILFS ADLQR
Sbjct: 631  DDQDGNEIELAFSKKRIADRKEWLTNFQPGTYLDQREKEIKYRDFINKELILFSLADLQR 690

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDG KPGQRKILFCSFK+ L KE KV QF GYVSEHSAYHHGEQSLASTI+GMAQ
Sbjct: 691  SIPSMVDGFKPGQRKILFCSFKRNLVKETKVAQFSGYVSEHSAYHHGEQSLASTIVGMAQ 750

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
             FVGSNNINLL P GQFGTR+ GGKD AS RYI+T+L+ ITR +F ++DD LL YLNEDG
Sbjct: 751  SFVGSNNINLLYPGGQFGTRSQGGKDAASPRYIFTKLSHITRSIFPKDDDTLLNYLNEDG 810

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            + IEPSWY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI AN+RRLLNDE  VPM PWYR
Sbjct: 811  QLIEPSWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIAANIRRLLNDEATVPMHPWYR 870

Query: 492  GFKGIIEKS--AKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            GFKG I+K+  A+  G  Y + G +E +D  + RITELP+R+WTQDYK F++S+     N
Sbjct: 871  GFKGSIQKANNARVDGATYTITGIIEAVDSTTLRITELPVRRWTQDYKDFIDSLRPDEKN 930

Query: 548  V-KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
              K+  IED    GD+  V  E+++  + + +  +EGLLKKFKLTTTI T+NMHLFD++G
Sbjct: 931  KDKEAFIEDCTAQGDNDDVYFELKLSEKNMNIAKEEGLLKKFKLTTTIGTTNMHLFDSDG 990

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            KI+KY+ PEQILEEFF LRL +Y +RK+ +L+N +  L  L+NK RFI  VV+ EIVV+N
Sbjct: 991  KIRKYDTPEQILEEFFKLRLQFYFKRKEVLLQNMKLDLKKLENKARFIRCVVNNEIVVNN 1050

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            RK+ADL +EL+QK F P PKK K AEP   GA                          DY
Sbjct: 1051 RKRADLFLELRQKNFDPFPKKKKRAEPAAVGATEEEENEESPEAANGVDP-------SDY 1103

Query: 727  EYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKE 786
            EYLLSM+IGTLTLE +Q                  T  KS+W+             D  +
Sbjct: 1104 EYLLSMAIGTLTLEKIQELNAEKEKVVNEVEELEKTTEKSLWLRDLDAFEKDLDVLDQMD 1163

Query: 787  AED--EKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESD 830
              D  E+KR+   + + +    G+KAA K  Q +K   K    ESD
Sbjct: 1164 LADAQERKRLRDENAKKA----GSKAAPK-KQRKKPAAKQPKVESD 1204


>B3H4G2_ARATH (tr|B3H4G2) DNA topoisomerase 2 OS=Arabidopsis thaliana GN=TOPII PE=3
            SV=1
          Length = 1438

 Score =  977 bits (2525), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 482/763 (63%), Positives = 586/763 (76%), Gaps = 12/763 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG+++ LLSWADFKQ+KDLKK+DG KT R+  + KL+DA +AGG+NS  CTLILTEG
Sbjct: 404  VGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVL-VEKLDDAAEAGGKNSRLCTLILTEG 462

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AG SV+G ++ GVFPLRGKLLNVREAS  QI +N+EI+N+KKILGL+QN +Y
Sbjct: 463  DSAKSLALAGRSVLGNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKY 522

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             NV SLRYG +MIM DQDHDGSHIKGLLINFIHSFWPSLL+VPSF+VEF TPI++A    
Sbjct: 523  ENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKATR-K 581

Query: 193  GTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
            GTK  LSFYSMPEYE W+E+L  NATGW IKYYKGLGTST +EG+EYF +LG H+KDFVW
Sbjct: 582  GTKKVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVW 641

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
            ED+ DG AIE+AFSKKK E RK W+ ++ PGN+ D    ++ Y DFVNKELILFS ADLQ
Sbjct: 642  EDEQDGEAIELAFSKKKIEARKNWLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADLQ 701

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPS+VDGLKPGQRKILF +FKK   KE+KV Q +GYVS  SAYHHGEQSLAS IIGMA
Sbjct: 702  RSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLSAYHHGEQSLASAIIGMA 761

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QD+VGSNNINLL PNGQFGTR  GGKD AS+RYI+T+L+P+TR LF ++DD LL+YLNED
Sbjct: 762  QDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNED 821

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+ IEP+WY+PIIP VLVNG+EGIGTGWS++IPNYNPR+I+ANVRRLLN E+MVPMDPWY
Sbjct: 822  GQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWY 881

Query: 491  RGFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI-TDGSP 546
            RGFKG IEK+A KEGG  Y + G  EE+DE + RITELPIR+W  DYK FL+S+ TD   
Sbjct: 882  RGFKGTIEKTASKEGGCTYTITGLYEEVDETTIRITELPIRRWNDDYKNFLQSLKTDNGA 941

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
                P  +D +   D+  VD ++ +  E +    QEG LKKFKLTTTI+TSNMHLFD +G
Sbjct: 942  ----PFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDKKG 997

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
             IKKY  PEQILEEFF LR +YYE+RK+ +++N E  LL L+NK RFIL V+SGEI+V+ 
Sbjct: 998  VIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNK 1057

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            RKKAD++ +L+QKGFTP P+K +S E  +AGA                          +Y
Sbjct: 1058 RKKADIVEDLRQKGFTPFPRKAESVEAAIAGAVDDDAAEEPEEILVDPESSSSYIPGSEY 1117

Query: 727  EYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            +YLL+M+I +LT+E V+                  T  KS+W+
Sbjct: 1118 DYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTTPKSLWL 1160


>D7L459_ARALL (tr|D7L459) DNA topoisomerase 2 OS=Arabidopsis lyrata subsp. lyrata
            GN=ARALYDRAFT_898932 PE=3 SV=1
          Length = 1432

 Score =  975 bits (2520), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 492/792 (62%), Positives = 598/792 (75%), Gaps = 11/792 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG+++ LLSWADFK+SKDLKK+DG KT R+  + KLEDA +AGG+NS  CTLILTEG
Sbjct: 402  VGKSGVVENLLSWADFKKSKDLKKSDGAKTGRVE-VEKLEDAAEAGGKNSRLCTLILTEG 460

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LA+AG +V+G ++YGVFPLRGKLLNVREAS  QI +N+EI+NIKKILGL+QN +Y
Sbjct: 461  DSAKPLALAGRTVLGENYYGVFPLRGKLLNVREASTTQITNNKEIENIKKILGLKQNMKY 520

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             NV SLRYGH+MIM DQDHDGSHIKGLLINFIHSFWPSLLKVPSF+VEF TPI++A +  
Sbjct: 521  DNVSSLRYGHMMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKAKNKA 580

Query: 193  GTK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              K LSFYSMPEYE W+E++  NATGW+IKYYKGLGTST +E +EYF++LG H+KDFVWE
Sbjct: 581  KKKVLSFYSMPEYEDWKESMKGNATGWEIKYYKGLGTSTTEEAKEYFKNLGLHKKDFVWE 640

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D+ DG AIE+AFSKKK E RK W+ N+ PG + D    ++ Y DFVNKELILFS ADLQR
Sbjct: 641  DEQDGEAIELAFSKKKIEARKNWLSNYVPGTHLDQREPKVTYSDFVNKELILFSMADLQR 700

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKILF +FKK + KE+KV Q +GYVS  SAYHHGEQSLAS IIGMAQ
Sbjct: 701  SIPSMVDGLKPGQRKILFTAFKKIVVKEMKVAQLVGYVSSMSAYHHGEQSLASAIIGMAQ 760

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            D+VGSNNINLL+PNGQFGTRN GGKD AS+RYI+T L+P+TR LF ++D  LL+YLNEDG
Sbjct: 761  DYVGSNNINLLQPNGQFGTRNSGGKDAASARYIFTILSPVTRILFPKDDHILLDYLNEDG 820

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEP+WY+PIIP VLVNGSEGIGTGWS++IPNYNPR+I+ANVR  LN E+MVPMDPWYR
Sbjct: 821  QSIEPTWYMPIIPTVLVNGSEGIGTGWSTFIPNYNPREIVANVRCRLNGESMVPMDPWYR 880

Query: 492  GFKGIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI-TDGSPN 547
            GFKG IEK+A KEGG  Y + G  EE+D+ + RITELPIR+W  DYKQFL+S+ TD    
Sbjct: 881  GFKGTIEKTASKEGGCTYTITGLYEEVDDTTIRITELPIRRWNDDYKQFLQSLKTDNGA- 939

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
               P  +D +   DD  VD ++ +  E +    QEG LKKFKLTTTI+TSNMHLFD +G 
Sbjct: 940  ---PFFQDVKAYNDDKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDRKGV 996

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            IKKY  PEQILEEFF LRL+YYE+RK+ +L+N E  LL L+NKVRFILGV+SGEI+V+NR
Sbjct: 997  IKKYATPEQILEEFFELRLEYYEKRKETMLKNLEIELLKLENKVRFILGVLSGEIIVNNR 1056

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKAD++ +L+Q+GFTP PKK +S E                                +Y+
Sbjct: 1057 KKADIVEDLRQRGFTPFPKKAESVE-AAVAGAVDDAAEESEEILVDPESSSTYIPGSEYD 1115

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL+M+IG+LT+E VQ                     KS+W+             D K+A
Sbjct: 1116 YLLAMAIGSLTIEKVQELLADRDKMIIAVEDMKKHTPKSLWLRDLESLDKELDKLDRKDA 1175

Query: 788  EDEKKRISQASK 799
            + E++R +   K
Sbjct: 1176 KAEEERKAAQEK 1187


>M8AFG0_TRIUA (tr|M8AFG0) DNA topoisomerase 2 OS=Triticum urartu GN=TRIUR3_20318
            PE=4 SV=1
          Length = 1449

 Score =  957 bits (2474), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 465/712 (65%), Positives = 556/712 (78%), Gaps = 32/712 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V++SG++  LLSWA+FK +K+LKKTDGTK   + GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 379  VSSSGVVTNLLSWAEFKLNKELKKTDGTKKTSIVGIPKLEDANDAGGKNSDKCTLILTEG 438

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+ VVGRDHYGVFPLRGKLLNVREAS+KQ+M+N EIQNIKKILGLQ  K+Y
Sbjct: 439  DSAKALAMAGIGVVGRDHYGVFPLRGKLLNVREASHKQLMENAEIQNIKKILGLQHEKKY 498

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQDHDGSHIKGLLINFIH  WPSLLKVPSF+VEF TPII+A    
Sbjct: 499  DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGK 558

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW-E 251
              K  FYSMP+YE+W+E+LG +A+ W IKYYKGLGTST +EGR+YF  +  H+KDFVW  
Sbjct: 559  AVK-PFYSMPDYEAWKEDLGASASSWTIKYYKGLGTSTAEEGRDYFDHIDLHKKDFVWAN 617

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
            D+ D  AIE+AFSKKK  +RK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 618  DEKDNEAIELAFSKKKIAERKEWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 677

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDG KPGQRKILFCSFKK L KE KV QFIGYVSEHSAYHHGEQSLASTIIGMAQ
Sbjct: 678  SIPSMVDGFKPGQRKILFCSFKKNLTKESKVAQFIGYVSEHSAYHHGEQSLASTIIGMAQ 737

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL+P GQFGTRN GGKD AS+RYI+T+L+PITR +F ++DD LL YLNEDG
Sbjct: 738  DFVGSNNINLLEPRGQFGTRNSGGKDAASARYIFTKLHPITRLIFPKDDDVLLNYLNEDG 797

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWY+PIIP+VLVNGSEGIGTGWS+Y+PNYNPRDIIAN++RLLN ET+VPM PWYR
Sbjct: 798  QSIEPSWYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNGETIVPMIPWYR 857

Query: 492  GFKG-IIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT------ 542
            GFKG +IE S+K  G  Y + G +EE+ +   +ITELP+R+WT DYK+FLES+       
Sbjct: 858  GFKGSLIETSSKATGVTYTITGVIEEVADTKLKITELPVRRWTTDYKEFLESMCPIPIKE 917

Query: 543  ---------------------DGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQ 581
                                 +   + + PL+E+ R   D A V+ E+ +  + + +  Q
Sbjct: 918  KEKSKDKNKEKKKDKDKDKDKEKEKSKEPPLLEEIRSQCDHADVEFELILTEQNMNIAKQ 977

Query: 582  EGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFE 641
            EGL KKFKLTTTI T+NMHLFD+ GKIKKY+ PE +L+EFF LR ++Y +RK+ +LEN  
Sbjct: 978  EGLEKKFKLTTTIGTTNMHLFDSHGKIKKYDTPEDVLKEFFDLRFEFYVKRKKVMLENMG 1037

Query: 642  RLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEP 693
              LL   NKVRFIL V+S EI+V+NRK+ADL  EL+QKG+   PKK   + P
Sbjct: 1038 NELLKYQNKVRFILAVISVEIIVNNRKRADLFDELKQKGYKAFPKKKPMSGP 1089


>A3AAF2_ORYSJ (tr|A3AAF2) DNA topoisomerase 2 OS=Oryza sativa subsp. japonica
            GN=OsJ_08043 PE=3 SV=1
          Length = 1487

 Score =  924 bits (2389), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 477/848 (56%), Positives = 578/848 (68%), Gaps = 79/848 (9%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V +S I+  LLSWA+FK SK+L+KTDG+K  RL GI KLEDAN AGG++S+ CTLILTEG
Sbjct: 402  VGSSAIVLNLLSWAEFKLSKELQKTDGSKRSRLTGIPKLEDANGAGGKDSNNCTLILTEG 461

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGRD+YGVFPLRGKLLNVREAS+KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 462  DSAKALAMAGISVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKQY 521

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQ  +    K +L                                
Sbjct: 522  DSTKGLRYGHLMIMTDQATNKRDKKIVL-------------------------------- 549

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
                 FYSMPEYE W+E+LG NA+GW IKYYKGLGTST  EGR+YF+D+ KH+KDFVW++
Sbjct: 550  ----PFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKN 605

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D + IE+AFSKK+  DRK W+ NF+ G + D     I Y DF+NKELI FS ADL RS
Sbjct: 606  DQDDNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRS 665

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFK+ L KEIKV QF GYVSEHSAYHHGEQSLASTI GMAQD
Sbjct: 666  IPSMVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQD 725

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL+PNGQFGTR+ GGKD AS+RYI+T L+PITR +F ++DD LL YL+EDG+
Sbjct: 726  FVGSNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQ 785

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLNDE + PMDPWYRG
Sbjct: 786  SIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRG 845

Query: 493  FKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG I+K+  + G   Y V G +E +D+ + RITELPIR+W+QDYK+FL SI     +  
Sbjct: 846  FKGSIQKTGTKAGGVSYTVTGIIEVVDDTTLRITELPIRRWSQDYKEFLISIGGTDKSKD 905

Query: 550  ----------------------DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKK 587
                                  +P IE F    DD  V+  I +  E +A+ +QEGL KK
Sbjct: 906  KDKDKGKGKGKVKEKEKKEKDIEPFIEAFDTYSDDKNVEFLITLSKENMAIALQEGLEKK 965

Query: 588  FKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVL 647
            FKLTTTI T+NMHLFD+ GKI+KY+ PE IL+EFF LRL++YE+RK+ +LEN E  L  L
Sbjct: 966  FKLTTTIGTTNMHLFDSNGKIRKYDTPEDILKEFFGLRLEFYEKRKRVLLENIELELKKL 1025

Query: 648  DNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXX 707
             NKVRFIL VV G+I+V+NRK+A+L +EL+QKGF P P+K + A P   GA         
Sbjct: 1026 SNKVRFILAVVEGDIIVNNRKRAELFVELKQKGFDPFPRKKQRAGPSAVGAIEEDEENEE 1085

Query: 708  XXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSM 767
                             DYEYLLSM+IGTLTLE VQ                  T  KS+
Sbjct: 1086 SPEAANVGS-------SDYEYLLSMAIGTLTLERVQQLIAEKGRMENEVAELKRTRPKSL 1138

Query: 768  WMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAA--KKPPQ--PRKNTKK 823
            WM             D K++ D       A +R +TR+ G  AA  K  P+  PRK    
Sbjct: 1139 WMRDLDAFEKELDALDEKDSMD-------AEERRATRNAGGGAAPNKAAPKRRPRKTATN 1191

Query: 824  TKNAESDN 831
            T+ AES +
Sbjct: 1192 TQAAESSD 1199


>A2X8M2_ORYSI (tr|A2X8M2) DNA topoisomerase 2 OS=Oryza sativa subsp. indica
            GN=OsI_08583 PE=3 SV=1
          Length = 1486

 Score =  917 bits (2370), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 476/847 (56%), Positives = 577/847 (68%), Gaps = 78/847 (9%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V +S I+  LLSWA+FK SK+L+KTDG+K  RL GI KLEDAN AGG++S+ CTLILTEG
Sbjct: 402  VGSSAIVLNLLSWAEFKLSKELQKTDGSKRSRLTGIPKLEDANGAGGKDSNNCTLILTEG 461

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAMAG+SVVGRD+YGVFPLRGKLLNVREAS+KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 462  DSAKALAMAGISVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKQY 521

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + K LRYGHLMIM DQ  +    K +L                                
Sbjct: 522  DSTKGLRYGHLMIMTDQATNKRDKKIVL-------------------------------- 549

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
                 FYSMPEYE W+E+LG NA+GW IKYYKGLGTST  EGR+YF+D+ KH+KDFVW++
Sbjct: 550  ----PFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVWKN 605

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D + IE+AFSKK+  DRK W+ NF+ G + D     I Y DF+NKELI FS ADL RS
Sbjct: 606  DQDDNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLLRS 665

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRKILFCSFK+ L KEIKV QF GYVSEHSAYHHGEQSLASTI GMAQD
Sbjct: 666  IPSMVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMAQD 725

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL+PNGQFGTR+ GGKD AS+RYI+T L+PITR +F ++DD LL YL+EDG+
Sbjct: 726  FVGSNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDEDGQ 785

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLNDE + PMDPWYRG
Sbjct: 786  SIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWYRG 845

Query: 493  FKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG I+K+  + G   Y V G +E +D+ + RITELPIR+W+QDYK+FL SI     +  
Sbjct: 846  FKGSIQKTGTKAGGVSYTVTGIIEVVDDTTLRITELPIRRWSQDYKEFLISIGGTDKSKD 905

Query: 550  ----------------------DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKK 587
                                  +P IE F    DD  V+  I +  E +A+ +QEGL KK
Sbjct: 906  KDKDKGKGKGKVKEKEKKEKDIEPFIEAFDTYSDDKNVEFLITLSKENMAIALQEGLEKK 965

Query: 588  FKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVL 647
            FKLTTTI T+NMHLFD+ GKI+KY+ PE IL+EFF LRL++YE+RK+ +LEN E  L  L
Sbjct: 966  FKLTTTIGTTNMHLFDSNGKIRKYDTPEDILKEFFGLRLEFYEKRKRVLLENIELELKKL 1025

Query: 648  DNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXX 707
             NKVRFIL VV G+I+V+NRK+A+L +EL+QKGF P P+K + A P   GA         
Sbjct: 1026 SNKVRFILAVVEGDIIVNNRKRAELFVELKQKGFDPFPRKKQRAGPSAVGAIEEDEENEE 1085

Query: 708  XXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSM 767
                             DYEYLLSM+IGTLTLE VQ                  T  KS+
Sbjct: 1086 SPEAANVGS-------SDYEYLLSMAIGTLTLERVQQLIAEKSRMENEVAELKRTRPKSL 1138

Query: 768  WMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPP---QPRKNTKKT 824
            WM             D K++ D       A +R +TR+ G  AA K     +PRK    T
Sbjct: 1139 WMRDLDAFEKELDALDEKDSMD-------AEERRATRNAGGGAAPKAAPKRRPRKTATNT 1191

Query: 825  KNAESDN 831
            + AES +
Sbjct: 1192 QAAESSD 1198


>M1A902_SOLTU (tr|M1A902) DNA topoisomerase 2 OS=Solanum tuberosum
           GN=PGSC0003DMG400006793 PE=3 SV=1
          Length = 1407

 Score =  876 bits (2264), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 405/543 (74%), Positives = 473/543 (87%), Gaps = 4/543 (0%)

Query: 15  NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
           N GI+D+LLSWADFK SKDLKKTDG K+ +++ + KLEDANDAGGRNSDKCTLILTEGDS
Sbjct: 398 NIGIVDSLLSWADFKNSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDS 456

Query: 75  AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
           AKALAMAG+SVVGRDHYGVFPLRGKLLNVREAS+KQ+ +N+EI++IKKILGLQ  KEY +
Sbjct: 457 AKALAMAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYES 516

Query: 135 VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
           VKSLRYGHLMIM DQDHDGSHIKGLLINFIH+FWPSLLKVPSF+VEF TPI++A H +G 
Sbjct: 517 VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGR 576

Query: 195 KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
            L+FY+MPEYE+WR +LG  ++GW IKYYKGLGTST +EG+EYF+DL KHRKDF+W D+ 
Sbjct: 577 ILAFYTMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQ 636

Query: 255 DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
           DG +IE+AFSKKK E RK W+R FEPG + D     I+Y +FVNKELILFS ADLQRSIP
Sbjct: 637 DGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIP 696

Query: 315 SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
           S++DGLKPGQRKILFC+FK+   KE KV QF GYVSEHSAYHHGEQSL+STIIGMAQD+V
Sbjct: 697 SMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYV 756

Query: 375 GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
           GSNN+NLL+PNGQFGTRN+GGKDHASSRYIYT L+PI R LF ++DD +L+YLNEDG+SI
Sbjct: 757 GSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSI 816

Query: 435 EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
           EP+WYIPIIP+VLVNGSEGIGTGWSSY+PNYNPRD++ANVRRLLNDE M PMDPWY+GFK
Sbjct: 817 EPTWYIPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFK 876

Query: 495 GIIEKSA-KEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
           G IEK+A KE G  Y V G +EE  E + RI+ELP+R+WT+DYKQFLES+T  +   KD 
Sbjct: 877 GTIEKTATKETGATYTVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDA 936

Query: 552 LIE 554
            I+
Sbjct: 937 FIK 939



 Score = 92.0 bits (227), Expect = 9e-16,   Method: Compositional matrix adjust.
 Identities = 58/145 (40%), Positives = 71/145 (48%), Gaps = 6/145 (4%)

Query: 649  NKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXX 708
            NKVRFILGVV GEI+V+NRK+ADLL+EL+ KGFTP PKK K  E  VA +          
Sbjct: 955  NKVRFILGVVKGEIIVNNRKRADLLLELKNKGFTPFPKK-KPVEAVVADS-----TDDAE 1008

Query: 709  XXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
                         +  DY+YLLSM+IGTLTLE VQ                     K +W
Sbjct: 1009 DSEESPEESNKGVRASDYDYLLSMAIGTLTLEKVQELCADRDKLNAEVEDMRNATPKDLW 1068

Query: 769  MXXXXXXXXXXXXQDGKEAEDEKKR 793
            M            QD  + + E+ R
Sbjct: 1069 MKDLDVLDKQLDEQDKLDIQTEEAR 1093


>E1Z4H4_CHLVA (tr|E1Z4H4) DNA topoisomerase 2 OS=Chlorella variabilis
            GN=CHLNCDRAFT_137783 PE=3 SV=1
          Length = 1566

 Score =  873 bits (2256), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 434/759 (57%), Positives = 541/759 (71%), Gaps = 18/759 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VAN G+++++LS+A FK  K+LKK DG K QRL GI KLEDANDAGGRNS  CTLILTEG
Sbjct: 398  VANCGVVNSILSFASFKADKELKKGDGAKRQRLTGIPKLEDANDAGGRNSAGCTLILTEG 457

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AGLSVVGRD +GVFPLRGKLLNVR+AS  QI  N EIQNIK+ILGLQ  K Y
Sbjct: 458  DSAKSLAVAGLSVVGRDRFGVFPLRGKLLNVRDASAAQITGNAEIQNIKQILGLQHGKVY 517

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ KSLRYGHLMIM DQDHDGSHIKGL++N+ H F+PSLLK+P F+VEF TPII+A    
Sbjct: 518  TDAKSLRYGHLMIMTDQDHDGSHIKGLIMNYFHHFYPSLLKLPGFLVEFITPIIKATKGK 577

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             T +SFY+MPEYE W E   +N  GW IKY+KGLGTST  E ++YF ++  HRK+FVW+ 
Sbjct: 578  ET-ISFYTMPEYEEWSET--HNTRGWTIKYFKGLGTSTADEAKQYFANIQSHRKEFVWDG 634

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG A+EMAFSKKK EDRK W++ F PG + DH A  I+Y  FV+KELILFSRADL+RS
Sbjct: 635  DADGQALEMAFSKKKVEDRKQWLQAFSPGTFLDHTADTISYSQFVHKELILFSRADLERS 694

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP++VDGLKPGQRKI+F  FK+ L  ++KV Q  GYVSEHSAYHHGE SL+ TI+G+AQD
Sbjct: 695  IPNMVDGLKPGQRKIMFACFKRNLKTDVKVSQLSGYVSEHSAYHHGEASLSGTIVGLAQD 754

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+N L P GQFGTR  GGKD AS RYI+T L P+TR LF+E+DD+LL YLNE+G+
Sbjct: 755  FVGSNNVNYLVPQGQFGTRLQGGKDAASPRYIFTRLAPLTRHLFNEHDDRLLAYLNEEGQ 814

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+P++P VLVNG+EGIGTGWS+ IPN+NPRDI+AN+R +L+ E  V M PWYRG
Sbjct: 815  SIEPEWYMPVVPTVLVNGAEGIGTGWSTSIPNFNPRDIVANLRLMLDGEQPVAMKPWYRG 874

Query: 493  FKGIIEK-SAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            FKG IE+   K  G  Y + G + ++D+ +  ITELPIRKWTQDYK+FLE +        
Sbjct: 875  FKGTIEEVPTKTSGKSYQICGVINQVDDTTLDITELPIRKWTQDYKEFLEEMVKPEDKNA 934

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
             P I+D+++   D +V   + +   K+   +  GLL KFKL T IST NM LF+AEG I+
Sbjct: 935  TPFIQDYKEYHTDLVVHFRVTLSESKMREALAAGLLDKFKLKTKISTGNMMLFNAEGAIQ 994

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY +PE IL +F+ LRL YY +R+  +L   E  LL + NKVRFIL VV G++ +SNR+K
Sbjct: 995  KYASPEDILRDFYDLRLAYYVKRRAALLRAAEADLLRISNKVRFILAVVGGQLKLSNRRK 1054

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
             D+  EL+ +G+  +P + K+A+ Q A                             Y+YL
Sbjct: 1055 KDVEGELEDEGYDKLPNQKKAAQ-QAA-----------IDEGEDGDGEGGASAPASYDYL 1102

Query: 730  LSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
            LSM + +LTLE VQ                 AT  K MW
Sbjct: 1103 LSMPLSSLTLEKVQALQSESEDWQATVQRLRATTEKDMW 1141


>C1E5N4_MICSR (tr|C1E5N4) DNA topoisomerase 2 OS=Micromonas sp. (strain RCC299 /
            NOUM17) GN=MICPUN_58377 PE=3 SV=1
          Length = 1459

 Score =  864 bits (2232), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 433/796 (54%), Positives = 539/796 (67%), Gaps = 15/796 (1%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            NSGI++ +LSWA FKQSK++KK+DG K  RL GI KL+DANDAGGRNS+ CTLILTEGDS
Sbjct: 427  NSGIVEQILSWASFKQSKEMKKSDGKKATRLTGIPKLDDANDAGGRNSEHCTLILTEGDS 486

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALA++GLSVVGRD YGVFPLRGKLLNVR+AS+ QIM+N EI +IK+ILGL+    Y +
Sbjct: 487  AKALAVSGLSVVGRDRYGVFPLRGKLLNVRDASHDQIMNNAEINHIKQILGLRHGTTYES 546

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
             KSLRYGH+MIM DQDHDGSHIKGLLINF+H+ +PSLLK+P F+VEF TPII+A     +
Sbjct: 547  AKSLRYGHIMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLVEFITPIIKATKGKQS 606

Query: 195  KLSFYSMPEYESWRENLGNNATG--WKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            K+ FY++PEY++W+E+     TG  W IKYYKGLGTST +E +EYF  L  H+K F W  
Sbjct: 607  KV-FYTLPEYDNWKEHAEETGTGRGWNIKYYKGLGTSTAKEAKEYFAALDHHKKTFAWTT 665

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG+ I+MAFSKK+ EDRK W+  +EPG Y D     + Y DF+NKELILFSRADL RS
Sbjct: 666  DGDGNLIDMAFSKKRVEDRKAWLNAYEPGTYLDMTGDDVRYDDFINKELILFSRADLMRS 725

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDG KP QRK+LF  FK+KL  +IKV Q  GYVSEHSAYHHGE SLASTI+G+AQD
Sbjct: 726  IPSVVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLASTIVGLAQD 785

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL P+GQFGTR  GGKDHAS RYI+T L PI R +F E DD LL+YL+EDG+
Sbjct: 786  FVGSNNVNLLVPSGQFGTRLQGGKDHASPRYIFTRLAPICRVIFPECDDALLDYLDEDGQ 845

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP  Y+PI+PLVLVNG++GIGTGWS+ IPN+NPRDI+AN+RR+L+DE    M PWYR 
Sbjct: 846  VIEPEHYLPILPLVLVNGADGIGTGWSTSIPNFNPRDIVANIRRILDDECTERMHPWYRN 905

Query: 493  FKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            FKG IE+   +G   Y + G  E +DE +  ITELP+R WT DYK FLE++         
Sbjct: 906  FKGTIEEEIVKGEIRYNITGKYEIVDETTLVITELPLRSWTTDYKDFLENMLSPKEKNAQ 965

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKK 610
            P I D++++  D  V   + M  E +A   ++G+ KKFKL   +STSNMH FD +G I K
Sbjct: 966  PFITDYKEHHTDTTVHFIVTMTPENMAKAQKDGIEKKFKLCAKVSTSNMHAFDEKGGITK 1025

Query: 611  YENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKA 670
            Y +PE I+E F PLRLD Y RR+  ++   E  L  + NKVRFIL VV GE+ +  +KK+
Sbjct: 1026 YSSPEAIMEAFVPLRLDAYARRRAMLIRQAEFELKRMSNKVRFILAVVDGEMTIGRKKKS 1085

Query: 671  DLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLL 730
             L+ EL+  G+  MPK  K+A    A                             Y+YLL
Sbjct: 1086 VLIEELEAAGYDKMPKTAKAAAAADAEPAESGLSDISEEGAPAPADG------ASYDYLL 1139

Query: 731  SMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW---MXXXXXXXXXXXXQDGKEA 787
            SM +  LT E V                   T  K +W   +            +D K A
Sbjct: 1140 SMPLWNLTQEKVDELVEEQRVKTAEVEELHGTTDKQLWIRDLDAFDAAMDVFDAEDAKAA 1199

Query: 788  EDEKKRISQASKRTST 803
            E+  K+  +A+ R  T
Sbjct: 1200 EELAKQ-QRAAARNQT 1214


>C1MN24_MICPC (tr|C1MN24) DNA topoisomerase 2 OS=Micromonas pusilla (strain
            CCMP1545) GN=MICPUCDRAFT_46870 PE=3 SV=1
          Length = 1473

 Score =  863 bits (2230), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 432/797 (54%), Positives = 548/797 (68%), Gaps = 24/797 (3%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            +SGI++ +LSWA FKQSK+LKK DG K  RL GI KL+DANDAGG+NS+ CTLILTEGDS
Sbjct: 428  SSGIVEQILSWASFKQSKELKKNDGAKKTRLTGIPKLDDANDAGGKNSEHCTLILTEGDS 487

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALA++GLSVVGRD YGVFPLRGKLLNVR+AS++QIM+N EI  IK+ILGL+   +Y +
Sbjct: 488  AKALAVSGLSVVGRDRYGVFPLRGKLLNVRDASHEQIMNNAEISYIKQILGLKHGIQYES 547

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
             KSLRYGH+MIM DQDHDGSHIKGLLINF+H+ +PSLLK+P F+VEF TPII+A     +
Sbjct: 548  AKSLRYGHIMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLVEFITPIIKATKGKKS 607

Query: 195  KLSFYSMPEYESWRENLGNNAT-GWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDD 253
            ++ FY+MPEYE+++E+LG+  T GW IKYYKGLGTST +E +EYF  L  HRK F W DD
Sbjct: 608  EV-FYTMPEYENFKESLGDAGTKGWSIKYYKGLGTSTSKEAKEYFAALAHHRKTFTWSDD 666

Query: 254  YDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
              G  I+MAFSKK+ +DRK W+  +EPG + D     + Y DFVNKELILFSRADL RSI
Sbjct: 667  NSGDLIDMAFSKKRVDDRKQWLTAYEPGTFLDMTGDDVGYDDFVNKELILFSRADLMRSI 726

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            PSVVDG KP QRK+LF  FK+KL  +IKV Q  GYVSEHSAYHHGE SLASTI+G+AQDF
Sbjct: 727  PSVVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLASTIVGLAQDF 786

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
            VGSNN+NLL P+GQFGTR  GGKDHAS RYI+T L PI R +F E DD LL+Y+NEDG+ 
Sbjct: 787  VGSNNVNLLVPSGQFGTRLQGGKDHASPRYIFTRLAPICRAIFPEADDALLDYINEDGQV 846

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP +Y+PI+PLVLVNG++GIGTGWS+ IPNYNPRD+  N+RRLLNDE    M PWYR F
Sbjct: 847  IEPDYYLPILPLVLVNGADGIGTGWSTSIPNYNPRDLTDNIRRLLNDEEPERMHPWYRNF 906

Query: 494  KGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
             G + +   +G   Y ++G  E ++E +  I+ELPIR WT DYK+FLE++ +       P
Sbjct: 907  NGSLTEEIVKGEIRYHISGAYEIVNETTLMISELPIRSWTTDYKEFLENMMNPKEKNATP 966

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I D++++  D  V   + M  EK+A   +EG+ KKFKL++ +STSNMH FDA G I+KY
Sbjct: 967  FITDYKEHHTDTTVHFVVTMTPEKMAQAQKEGIEKKFKLSSKVSTSNMHCFDANGGIQKY 1026

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
             NPE+I++ F PLRL  YE+R+  ++   E  L  L NK RFIL VV  ++ +  +KK+ 
Sbjct: 1027 SNPEEIMKAFVPLRLKAYEKRRTMLIRQAESELKRLANKTRFILAVVDEKLSIGRKKKSA 1086

Query: 672  LLMELQQKGFTPMPKKGK--SAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            L+ EL+  GF  M K  K  +A  ++A                            +Y+YL
Sbjct: 1087 LVEELESLGFDKMTKTQKVSAAIDEIAEGDEEAADAVESG--------------ANYDYL 1132

Query: 730  LSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW---MXXXXXXXXXXXXQDGKE 786
            LSM +  LT E V                  AT  K +W   +            +D K+
Sbjct: 1133 LSMPLWNLTQEKVDELVTEKESKEEEVAALHATTDKELWIKDLDAFEEALMAFDIEDAKQ 1192

Query: 787  AEDEKKRISQASKRTST 803
            A D  K+  +A+ R +T
Sbjct: 1193 AADLAKQ-QRAAARNAT 1208


>D8U578_VOLCA (tr|D8U578) DNA topoisomerase 2 OS=Volvox carteri GN=VOLCADRAFT_94598
            PE=3 SV=1
          Length = 1126

 Score =  857 bits (2215), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 412/685 (60%), Positives = 517/685 (75%), Gaps = 6/685 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  +G+ D+++ +A+FK  KDLKK DG K  RL G+ KL+DANDAGG  S  CTLILTEG
Sbjct: 387  VLKAGLSDSIIKYAEFKSQKDLKKGDGVKRSRLVGMAKLDDANDAGGPRSTDCTLILTEG 446

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA++GL VVGR+HYGVFPLRGKLLNVREAS  QI  N+EIQNIK+I+GLQ  + Y
Sbjct: 447  DSAKSLAVSGLGVVGRNHYGVFPLRGKLLNVREASAVQIAANQEIQNIKQIMGLQHGRVY 506

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +  SLRYGHLMIM DQDHDGSHIKGL++NF+HSF+PSLLK+P FM+EF TPI++A    
Sbjct: 507  DSTSSLRYGHLMIMTDQDHDGSHIKGLIMNFMHSFFPSLLKIPGFMLEFITPIVKARRGR 566

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             TK+ FY+MPEYE+W+E+L NN +GW IKYYKGLGTST +E +EYF  L  HRK+FVW  
Sbjct: 567  ETKV-FYTMPEYEAWKESLDNNTSGWDIKYYKGLGTSTKEEAQEYFSRLNLHRKEFVWTG 625

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG AIE+AFSKK+ +DRK W+ NF PG Y D  A +I+Y DF+NKELILFSRADL RS
Sbjct: 626  DEDGDAIELAFSKKRVDDRKEWLSNFVPGTYLDQSAEKISYADFINKELILFSRADLDRS 685

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP+V+DGLKPGQRKI+F  FK+ L K+IKV Q   YV+EHSAYHHGEQSLASTI+ +AQD
Sbjct: 686  IPNVLDGLKPGQRKIMFACFKRNLKKDIKVAQLSAYVAEHSAYHHGEQSLASTIVNLAQD 745

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL P+GQFGTR  GGKD AS+RYIYT L  +TR LF+E+DD LL+YLNE+G+
Sbjct: 746  FVGSNNINLLHPSGQFGTRLQGGKDAASARYIYTRLEKLTRHLFNEHDDVLLKYLNEEGQ 805

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+PI+P VLVNG+EGIGTGWS++IPNYNPRDIIAN+RRLLN E   P+ PWYRG
Sbjct: 806  SIEPEWYLPILPTVLVNGAEGIGTGWSTFIPNYNPRDIIANLRRLLNGEEQDPLHPWYRG 865

Query: 493  FKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            F G I +   + G   Y+V G V +    +  +TELP+RKWTQDYK+FLE++       +
Sbjct: 866  FTGTITEVPHKSGSRSYVVGGLVAQTGPNTIEVTELPVRKWTQDYKEFLETLLRPQDKDE 925

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFDAEGK 607
             PLI D+ ++  D+ V   + +   K+  ++    GL  KFKL   ++TSNM LF  +G 
Sbjct: 926  APLIADYHEHHSDSNVHFVVELLPGKLDELLATPGGLEAKFKLQAKVTTSNMMLFQKDGI 985

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            IK Y++PE I+ EFF LRLDYYE+R+  +L   +   +  DNKVRFIL VV G++ V NR
Sbjct: 986  IKHYQSPEAIIAEFFELRLDYYEKRRIAMLRFAQMDQMRADNKVRFILAVVHGKLEVRNR 1045

Query: 668  KKADLLMELQQKGFTPMPKKGKSAE 692
            K+ D+  +L+ +GF  M K   + +
Sbjct: 1046 KRVDIEKDLEAQGFDRMSKTNTATK 1070


>I0YZH1_9CHLO (tr|I0YZH1) DNA topoisomerase 2 OS=Coccomyxa subellipsoidea C-169
            GN=COCSUDRAFT_36592 PE=3 SV=1
          Length = 1189

 Score =  853 bits (2204), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 413/732 (56%), Positives = 529/732 (72%), Gaps = 21/732 (2%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
             GI D + ++A FK  K+LKKTDG K  R+ G+ KL+DANDAGGRNS++CTLILTEGDSA
Sbjct: 396  CGITDLVNAFATFKNEKELKKTDGAKRSRITGLTKLDDANDAGGRNSEQCTLILTEGDSA 455

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNV 135
            K+L +AG+SV GRD +GVFPLRGKLLNVR+A+  QI  N EI  IK+ILGLQ  K Y + 
Sbjct: 456  KSLVIAGMSVAGRDQFGVFPLRGKLLNVRDAAVTQINGNAEINAIKQILGLQHGKSYDST 515

Query: 136  KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNG-T 194
            K LRYGHLMIM DQDHDGSHIKGL++NF+H F+PSLLKV  F++EF TPI++   S G  
Sbjct: 516  KQLRYGHLMIMTDQDHDGSHIKGLIMNFLHHFYPSLLKVKGFLLEFITPIVKV--SKGKQ 573

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
            KLSF++MPEYE+W+++    + GW IKYYKGLGTS  +E +EYF  + +HRK FV+  + 
Sbjct: 574  KLSFFTMPEYEAWKKS---ASPGWTIKYYKGLGTSDKKEAQEYFAGIDQHRKSFVYTGEE 630

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            D  AIE+AFSKKK E+RK W+  FEPG Y D     I+Y DFVNKELILFSRADL+RSIP
Sbjct: 631  DDQAIELAFSKKKIEERKQWLAGFEPGTYLDQSVDEISYSDFVNKELILFSRADLERSIP 690

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            ++VDGLKPGQRKILFC FK+ + +++KV Q  G+VS  +AYHHGE SL STIIG+A +F+
Sbjct: 691  NMVDGLKPGQRKILFCCFKRNIRRDVKVAQLSGFVSADTAYHHGEASLQSTIIGLAHNFI 750

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNN+NLL P GQFGTR  GGKD A +RYI T L+PI R +FHE+DDKLL+YL E+G+SI
Sbjct: 751  GSNNVNLLVPQGQFGTRLQGGKDAAGARYIMTRLDPIARVVFHEHDDKLLDYLKEEGQSI 810

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP WY+PI+P+VLVNG+EGIGTGWS+YIPNYNPRDI+AN+RRLL  E +V M PWY GFK
Sbjct: 811  EPHWYLPILPMVLVNGAEGIGTGWSTYIPNYNPRDIVANLRRLLAGEEVVAMQPWYNGFK 870

Query: 495  GIIEK-SAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G I++  +K  G  Y V+GTV ++DE +  ITELP+RKWTQDYK+FLE +         P
Sbjct: 871  GTIQEIPSKTAGKSYNVHGTVAQVDESTLEITELPVRKWTQDYKEFLEGLIKPEEKTGPP 930

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            ++ D+R++  DA V   +++   ++   +  GL  KFKLT  +S  NM LFD  G IK+Y
Sbjct: 931  ILSDYREHHSDADVHFTLQLLPGQMDACLAAGLHAKFKLTNKMSCGNMVLFDQRGVIKRY 990

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
            E  E IL++F+ LR+DYY +R+  ++   E  + +L N+ RFIL VVSGE+VVSNRKKAD
Sbjct: 991  ETAEDILKDFYELRIDYYAKRRLCLIREAEFQMRILANETRFILAVVSGELVVSNRKKAD 1050

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ +L++ G+  MP K K+A                               +  Y+YLLS
Sbjct: 1051 IVADLERAGYDKMPPKKKAA------------VVASMDDQEELAEEAIVEVKVTYDYLLS 1098

Query: 732  MSIGTLTLESVQ 743
            M I +LTLE VQ
Sbjct: 1099 MPISSLTLEKVQ 1110


>A8JD08_CHLRE (tr|A8JD08) DNA topoisomerase 2 (Fragment) OS=Chlamydomonas
            reinhardtii GN=TOP2 PE=3 SV=1
          Length = 1167

 Score =  852 bits (2201), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 429/765 (56%), Positives = 538/765 (70%), Gaps = 16/765 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  +G+ D+++ +A+FK  K+LKK DGTK  RL GI KL+DANDAGG  S +CTLILTEG
Sbjct: 402  VLKAGLSDSIIRFAEFKSQKELKKGDGTKRSRLHGITKLDDANDAGGPRSRECTLILTEG 461

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL VVGRDHYGVFPLRGKLLNVREAS  QI  N EIQNIK+I+GLQ  K Y
Sbjct: 462  DSAKALAISGLGVVGRDHYGVFPLRGKLLNVREASAAQIAANAEIQNIKQIMGLQHGKVY 521

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             N  SLRYGHLMIM DQDHDGSHIKGL++NF+HSF+PSLL++P F++EF TPI++A    
Sbjct: 522  ENTTSLRYGHLMIMTDQDHDGSHIKGLIMNFLHSFFPSLLRIPGFLLEFITPIVKARRGR 581

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             TK+ FY+MPEYE+W+E+LGN  T W IKYYKGLGTST +E +EYF  L  HRK+FVWE 
Sbjct: 582  DTKV-FYTMPEYEAWKESLGNATTAWDIKYYKGLGTSTKEEAQEYFSRLDLHRKEFVWEG 640

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG +IE+AFSKK+ +DRK W+ NF PG + D  A RI+Y DF+N+ELILFSRADL RS
Sbjct: 641  DEDGDSIELAFSKKRVDDRKEWLSNFVPGTFLDQSADRISYSDFINRELILFSRADLDRS 700

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS++DGLKPGQRKIL+  FK+ L K+IKV Q   YV+EHSAYHHGE SLASTI+ +AQD
Sbjct: 701  IPSMLDGLKPGQRKILYACFKRNLKKDIKVAQLSAYVAEHSAYHHGEGSLASTIVNLAQD 760

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL P+GQFGTR  GGKD AS+RYIYT L  +TR LF+ENDD+LL YLNE+G+
Sbjct: 761  FVGSNNVNLLHPSGQFGTRLQGGKDAASARYIYTRLAALTRHLFNENDDQLLTYLNEEGQ 820

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+PI+P VL+NG++GIGTGWS+ IPNYNPRDI+AN+RRLL  E    M PWYRG
Sbjct: 821  SIEPEWYMPILPTVLINGADGIGTGWSTTIPNYNPRDIMANLRRLLEGEAQEAMHPWYRG 880

Query: 493  FKGIIEKSA--KEG--GYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            F G I ++A  K G   Y+V+GTV +    +  ITELPIRKWTQDYK+FLE++   +  V
Sbjct: 881  FNGNIAEAATHKSGSRSYVVSGTVTQTGPNTIEITELPIRKWTQDYKEFLETLLRPTEKV 940

Query: 549  K---DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFD 603
            +    P+I D+ ++  D+ V   + +   K+  ++    GL  KFKLTT I+TSNM LFD
Sbjct: 941  RRDEAPIIADYSEHHSDSNVHFVVELLPGKMEELLASPGGLDGKFKLTTKIATSNMMLFD 1000

Query: 604  AEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIV 663
              G IK Y +PE I+ EF+ LRLDYYE+R+  +L+         DN++RFIL VV G + 
Sbjct: 1001 HSGMIKHYSSPEMIVAEFYELRLDYYEKRRIAMLKVASLDQKRADNRIRFILAVVEGRLE 1060

Query: 664  VSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKR 723
            V  RK+ADL  +L+ +GF  + K G   + ++                            
Sbjct: 1061 VRGRKRADLERDLEAQGFDRLGKAGAKVKVRITEVAEDGEEGEGGEAAVTASNG------ 1114

Query: 724  GDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
              Y+YLLSMSI  LT E +                  +   + MW
Sbjct: 1115 ASYDYLLSMSIYNLTREKIAKLQEEAAKAKERVEYLCSITGRDMW 1159


>A4S645_OSTLU (tr|A4S645) DNA topoisomerase 2 OS=Ostreococcus lucimarinus (strain
            CCE9901) GN=OSTLU_41836 PE=3 SV=1
          Length = 1292

 Score =  843 bits (2178), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 426/783 (54%), Positives = 528/783 (67%), Gaps = 27/783 (3%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
            SG++D ++SWA FKQSK+LKKTDG K  RL GI KL+DANDAGGRNS+ CTLILTEGDSA
Sbjct: 403  SGVVDNIMSWAQFKQSKELKKTDGAKRSRLTGIPKLDDANDAGGRNSESCTLILTEGDSA 462

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNV 135
            KALA++GLSVVGRD YGVFPLRGKLLNVR+AS++QI +N EI +IK+ILGLQ  KEY + 
Sbjct: 463  KALAVSGLSVVGRDKYGVFPLRGKLLNVRDASHEQIKNNTEINHIKQILGLQHGKEYDSA 522

Query: 136  KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK 195
            KSLRYG LMIM DQDHDGSHIKGLLINF+H+ +PSLLK+P F++EF TPII+A     +K
Sbjct: 523  KSLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLLEFITPIIKATKGKQSK 582

Query: 196  LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYD 255
            + FY+MPEYE+W+E   +  +GW IKYYKGLGTST  E +EYF  L  HRK FVW+ D D
Sbjct: 583  V-FYTMPEYEAWKE-ANDGTSGWSIKYYKGLGTSTANEAKEYFASLDHHRKSFVWQSDGD 640

Query: 256  GSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPS 315
            G  I+M+FSKK+  DRK W+  +EPG + D     I Y +F+NKELILFSRADL RSIPS
Sbjct: 641  GDLIDMSFSKKRVVDRKAWLTAYEPGTFLDMTGEDIRYDEFINKELILFSRADLLRSIPS 700

Query: 316  VVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVG 375
            +VDG KP QRK+LF  FK+KL  +IKV Q  GYVSEHSAYHHGE SLA TI+ +AQDFVG
Sbjct: 701  MVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLAMTIVNLAQDFVG 760

Query: 376  SNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIE 435
            SNNINLL P+GQFGTR  GGKDHAS RYI+T L+ + R +F E DD LL YL+EDG+ IE
Sbjct: 761  SNNINLLVPSGQFGTRLQGGKDHASPRYIFTRLHEVCRAMFPECDDALLNYLDEDGQRIE 820

Query: 436  PSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKG 495
            P +Y P++PLVLVNG+EGIGTGWS+ IPN+NPRD+IAN+R +L  E+ V M PWYR FKG
Sbjct: 821  PDYYYPVLPLVLVNGAEGIGTGWSTSIPNFNPRDLIANIRLVLEGESPVQMHPWYRHFKG 880

Query: 496  IIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLI 553
             I +   +G   Y V G+    DE +  +TELP+R WT DYK+FLE +         P I
Sbjct: 881  SITEELVKGETRYNVTGSYNIRDECTLEVTELPLRSWTSDYKEFLEEMLVPKTKTAKPFI 940

Query: 554  EDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYEN 613
             D+++   D+ V   I M  E +A     G+ KKFKL+T ++ +NMHLF+ +G I KY +
Sbjct: 941  TDYKEYHTDSTVHFVITMPPENLAAAQASGIEKKFKLSTKLNITNMHLFNEQGVITKYSS 1000

Query: 614  PEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLL 673
            P  ILE F PLRL  Y +R++ ++   E  L  L NK+RFIL VV G +VV+ +KK +L+
Sbjct: 1001 PVAILEAFVPLRLKAYSQRREMLIRLAESQLKRLSNKMRFILAVVDGSLVVNRKKKQELI 1060

Query: 674  MELQQKGFTPMPK--KGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
             EL+   +  +PK  KG  AE    G                          G Y+YLL 
Sbjct: 1061 AELEALCYDRLPKTDKGSVAELDEDGEFIANDVA------------------GSYDYLLG 1102

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEK 791
            M +  LTLE V                   T  K +WM             D   AEDE+
Sbjct: 1103 MPLWNLTLEKVDELCAEKEAKEAEVAELHKTTEKDLWMKDLDTLEQTLELLD---AEDEE 1159

Query: 792  KRI 794
             RI
Sbjct: 1160 SRI 1162


>G0T007_RHOG2 (tr|G0T007) DNA topoisomerase 2 OS=Rhodotorula glutinis (strain ATCC
            204091 / IIP 30 / MTCC 1151) GN=RTG_02278 PE=3 SV=1
          Length = 1591

 Score =  834 bits (2155), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 409/732 (55%), Positives = 536/732 (73%), Gaps = 12/732 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SG++D +++WA FKQ + LKKTDG+K  R+ G+VKLEDAN+AG RN +KCTLILTEG
Sbjct: 549  VAKSGVIDNIVNWAKFKQDQALKKTDGSKRSRITGLVKLEDANNAGTRNGNKCTLILTEG 608

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL+VVGRD+YGVFPLRGKLLNVREA+ K +++N EIQ IK+I+GLQQ K Y
Sbjct: 609  DSAKALAVSGLAVVGRDNYGVFPLRGKLLNVREATGKALLENAEIQAIKQIMGLQQGKTY 668

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++  SLRYG LMIMADQDHDGSHIKGL+INF+  ++PSLLK+P+F+VEF TPI++   S 
Sbjct: 669  TSTDSLRYGSLMIMADQDHDGSHIKGLIINFLDYWFPSLLKLPNFLVEFITPIVKV--SK 726

Query: 193  GTK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            G K +SF+++PEYE+W+    ++  GWKIKY+KGLGTS   + ++YF D+ +HR  F   
Sbjct: 727  GKKEISFFTIPEYEAWKAET-DDGRGWKIKYFKGLGTSDTNDAKKYFSDMNRHRLPFKEL 785

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
               D + I+MAF+KKKA+DRK W+R F PG Y DH    +  KDF+NKELILFS AD  R
Sbjct: 786  TPEDRALIDMAFNKKKADDRKEWLRGFVPGTYMDHDVDEVPIKDFINKELILFSMADNIR 845

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPSVVDG KPGQRK+LF  FK+KL  EIKVGQ  GY+SEHSAYHHG+ SL  TI+G+AQ
Sbjct: 846  SIPSVVDGFKPGQRKVLFGCFKRKLKNEIKVGQLSGYISEHSAYHHGDASLQGTIVGLAQ 905

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            +FVGSNNIN+L PNGQFGTR  GGKD AS+RYI+T +  ITR LFH +DD +L+YLN+DG
Sbjct: 906  NFVGSNNINVLDPNGQFGTRLQGGKDAASARYIFTNVAQITRTLFHPSDDAILDYLNDDG 965

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWYIPI+P+VLVNGS+GIGTGWSS+IPN+NP DI+AN+RR L+ E M P+ PWYR
Sbjct: 966  QSIEPSWYIPILPMVLVNGSDGIGTGWSSFIPNFNPSDIVANLRRKLDGEEMEPIHPWYR 1025

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            GF+G IEK AKEG Y   GT++ ID+ +  ITELPIR WTQ+YK+ LES   GS + +  
Sbjct: 1026 GFRGTIEKDAKEG-YKCTGTIQRIDDSTVEITELPIRTWTQNYKEMLESWVAGS-DKQAA 1083

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
              +D+++   D  V   + +       I ++GL K FK+T+ ++TSNM  FD  GKIKKY
Sbjct: 1084 WCKDYKEYHTDTTVHFVVTLTTAGKEAIEKDGLEKVFKVTSKLNTSNMVCFDPTGKIKKY 1143

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
               E I+ +F+ +RL++Y +RK++++   E +   L N+ RFI  ++  ++V+SNRK+AD
Sbjct: 1144 ATAEDIVSDFYDVRLEFYHKRKKHLVSELELVHDRLSNQARFIKMIIDKQLVLSNRKRAD 1203

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ EL++KGF P PK  K     VAG                           DY+YLL+
Sbjct: 1204 IVAELRKKGFRPFPKVQKM---HVAG---DVDANGDGDEEVEDPEAVEAGADSDYDYLLN 1257

Query: 732  MSIGTLTLESVQ 743
            M + +LT E V+
Sbjct: 1258 MQLSSLTREKVE 1269


>M7WCM6_RHOTO (tr|M7WCM6) DNA topoisomerase II OS=Rhodosporidium toruloides NP11
            GN=RHTO_06677 PE=4 SV=1
          Length = 1562

 Score =  832 bits (2148), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 408/732 (55%), Positives = 535/732 (73%), Gaps = 12/732 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SG++D +++WA FKQ + LKKTDG+K  R+ G+VKLEDAN+AG RN +KCTLILTEG
Sbjct: 527  VAKSGVIDNIVNWAKFKQDQALKKTDGSKRSRITGLVKLEDANNAGTRNGNKCTLILTEG 586

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL+VVGRD+YGVFPLRGKLLNVREA+ K +++N EIQ IK+I+GLQQ K Y
Sbjct: 587  DSAKALAVSGLAVVGRDNYGVFPLRGKLLNVREATGKALLENAEIQAIKQIMGLQQGKTY 646

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++  SLRYG LMIMADQDHDGSHIKGL+INF+  ++PSLLK+P+F+VEF TPI++   S 
Sbjct: 647  TSTDSLRYGSLMIMADQDHDGSHIKGLIINFLDYWFPSLLKLPNFLVEFITPIVKV--SK 704

Query: 193  GTK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            G K +SF+++PEYE+W+    ++  GWKIKY+KGLGTS   + ++YF D+ +HR  F   
Sbjct: 705  GKKEISFFTIPEYEAWKAET-DDGRGWKIKYFKGLGTSDTNDAKKYFGDMNRHRLPFKEL 763

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
               D + I+MAF+KKKA+DRK W+R F PG Y DH    +  KDF+NKELILFS AD  R
Sbjct: 764  TPEDRALIDMAFNKKKADDRKEWLRGFVPGTYMDHDVDEVPIKDFINKELILFSMADNIR 823

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPSVVDG KPGQRK+LF  FK+KL  EIKVGQ  GY+SEHSAYHHG+ SL  TI+G+AQ
Sbjct: 824  SIPSVVDGFKPGQRKVLFGCFKRKLKNEIKVGQLSGYISEHSAYHHGDASLQGTIVGLAQ 883

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            +FVGSNNIN+L PNGQFGTR  GGKD AS+RYI+T +  ITR LFH +DD +L+YLN+DG
Sbjct: 884  NFVGSNNINVLDPNGQFGTRLQGGKDAASARYIFTNVAQITRTLFHPSDDAILDYLNDDG 943

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEPSWYIPI+P+VLVNGS+GIGTGWSS+IPN+NP DI+AN+RR L+ E M P+ PWYR
Sbjct: 944  QSIEPSWYIPILPMVLVNGSDGIGTGWSSFIPNFNPSDIVANLRRKLDGEEMEPIHPWYR 1003

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            GF+G IEK AKEG Y   GT++ ID+ +  ITELPIR WTQ+YK+ LES   GS + +  
Sbjct: 1004 GFRGTIEKDAKEG-YKCTGTIQRIDDSTVEITELPIRTWTQNYKEMLESWVAGS-DKQAA 1061

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
              +D+++   D  V   + +       I ++GL K FK+T+ ++TSNM  FD  GKIKKY
Sbjct: 1062 WCKDYKEYHTDTTVHFVVTLTTAGKEAIEKDGLEKVFKVTSKLNTSNMVCFDPTGKIKKY 1121

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
               E I+ +F+ +RL++Y +RK++++   E +   L N+ RFI  ++  ++V+SNRK+AD
Sbjct: 1122 ATAEDIVSDFYDVRLEFYHKRKKHLVSELELVHDRLSNQARFIKMIIDKQLVLSNRKRAD 1181

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ EL++K F P PK  K     VAG                           DY+YLL+
Sbjct: 1182 IVAELRKKDFRPFPKVQKM---HVAGDVDANGDGDEEVEDPDAVEAGAD---SDYDYLLT 1235

Query: 732  MSIGTLTLESVQ 743
            M + +LT E V+
Sbjct: 1236 MQLSSLTREKVE 1247


>K3X2K0_PYTUL (tr|K3X2K0) DNA topoisomerase 2 OS=Pythium ultimum GN=PYU1_G011424
            PE=3 SV=1
          Length = 1522

 Score =  828 bits (2138), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 434/839 (51%), Positives = 554/839 (66%), Gaps = 40/839 (4%)

Query: 5    TYMLQ---MFAVANSGILDTLLSWADFKQSKDLKKTDG--TKTQRLRGIVKLEDANDAGG 59
            TY L    +  +  SG+++ +LS+A +KQ+ +L++  G   K  RL GI KL+DAN+AG 
Sbjct: 459  TYTLSEKFLKQIEKSGMVERILSFAQYKQTAELRRKGGGGAKKVRLTGIAKLDDANNAGT 518

Query: 60   RNSDKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQN 119
                 CTLI+TEGDSAK +A+ GLSVVGRD+YGVFPLRGKLLNVREAS+ QI+ NEEIQN
Sbjct: 519  SKGQDCTLIVTEGDSAKTIAVGGLSVVGRDYYGVFPLRGKLLNVREASHAQILKNEEIQN 578

Query: 120  IKKILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMV 179
            + KILGL+  ++Y + KSLRYGHLMIMADQDHDGSHIKGL+INFIH FWPSLL++  F+ 
Sbjct: 579  VVKILGLKYGQKYESTKSLRYGHLMIMADQDHDGSHIKGLVINFIHHFWPSLLQIDGFIQ 638

Query: 180  EFTTPIIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFR 239
            EF TPI++          FY++PEY +WRE + NN  GW IKYYKGLGTST QE +EYF 
Sbjct: 639  EFITPIVKCTKGKNNSKVFYTIPEYNAWRE-VTNNGRGWSIKYYKGLGTSTTQEAKEYFS 697

Query: 240  DLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNK 299
            DL  H+  F ++ D DG AI+MAFSKK+ E+RK W+R ++ G + D+    + Y +FVNK
Sbjct: 698  DLKTHQVGFTYDGDEDGDAIDMAFSKKRVEERKDWLRGYQAGTHVDYDVDDMAYSEFVNK 757

Query: 300  ELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGE 359
            ELILFS AD  RSIPSVVDG KP QRK+LFC FK+ L  EIKV Q  GYVSEHSAYHHGE
Sbjct: 758  ELILFSMADNMRSIPSVVDGFKPSQRKVLFCCFKRNLKVEIKVAQLAGYVSEHSAYHHGE 817

Query: 360  QSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHEN 419
            QSL  TII MAQDFVGSNN++LL PNGQFGTR +GGKD AS RYI+T L  + R +F   
Sbjct: 818  QSLNGTIINMAQDFVGSNNVHLLSPNGQFGTRLMGGKDAASPRYIFTNLEQVARRIFDPL 877

Query: 420  DDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLN 479
            D+ +L YL++DG+SIEP +Y+PIIP+ LVNGSEGIGTGWSS IPNYNP DII N+R+ LN
Sbjct: 878  DNDVLNYLDDDGQSIEPDFYVPIIPMALVNGSEGIGTGWSSSIPNYNPLDIIKNLRQKLN 937

Query: 480  DETMVPMDPWYRGFKG-IIEKSAKEGG----YIVNGTVEEIDEQSFRITELPIRKWTQDY 534
             E + P+ PWYRGF G IIEKS+ +      ++V G  E  DE +  I+ELP++ WTQ Y
Sbjct: 938  GEDLSPLVPWYRGFSGHIIEKSSGKPSDNQTFLVQGLYEIKDESTLVISELPVKTWTQTY 997

Query: 535  KQFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTT 592
            KQFLES+ +         I+DFR+N  DA V   I  + + ++ I     G++KKFKL T
Sbjct: 998  KQFLESLLESG------TIKDFRENHTDAKVLFTITFEPKTLSDICSAPGGVVKKFKLET 1051

Query: 593  TISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVR 652
            +ISTSNMHLFD+ G IKKYENP +ILEEF+ +RLDYY RRK  +L   E  + +L NK R
Sbjct: 1052 SISTSNMHLFDSTGHIKKYENPHEILEEFYAIRLDYYGRRKAALLRKLEEQIKILSNKTR 1111

Query: 653  FILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXX 712
            F+L VV G +VVSNRKK DLL +L   G+  +    K+A+ + +G               
Sbjct: 1112 FVLAVVDGSLVVSNRKKQDLLEQLVADGYDQVL--AKTAKAKKSGDNDEESDEEEATDAA 1169

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXX 772
                      RG Y+YLLSM I +LT E V+                 AT  + +W+   
Sbjct: 1170 ----------RG-YDYLLSMKILSLTKERVEKLRAELQDREQEHSKLEATTIEQLWLGDL 1218

Query: 773  XXXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDN 831
                         E E+E+ +I+ +     T   G K  K   +  K +KK  N++ D+
Sbjct: 1219 DQLEAVLV-----ETEEERAKIAAS---VPTPKKGAKGRKPNGKTAKKSKKRGNSDDDS 1269


>Q0DYE1_ORYSJ (tr|Q0DYE1) DNA topoisomerase 2 (Fragment) OS=Oryza sativa subsp.
           japonica GN=Os02g0699700 PE=2 SV=1
          Length = 956

 Score =  822 bits (2124), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 385/534 (72%), Positives = 453/534 (84%), Gaps = 5/534 (0%)

Query: 13  VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
           V +S I+  LLSWA+FK SK+L+KTDG+K  RL GI KLEDAN AGG++S+ CTLILTEG
Sbjct: 402 VGSSAIVLNLLSWAEFKLSKELQKTDGSKRSRLTGIPKLEDANGAGGKDSNNCTLILTEG 461

Query: 73  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
           DSAKALAMAG+SVVGRD+YGVFPLRGKLLNVREAS+KQIM+N EIQNIK+ILGLQ  K+Y
Sbjct: 462 DSAKALAMAGISVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKQY 521

Query: 133 SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            + K LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSL+K+PSF+VEF TPII+A +  
Sbjct: 522 DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLIKIPSFLVEFITPIIKATNKR 581

Query: 193 GTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             K  L FYSMPEYE W+E+LG NA+GW IKYYKGLGTST  EGR+YF+D+ KH+KDFVW
Sbjct: 582 DKKIVLPFYSMPEYEQWKESLGGNASGWSIKYYKGLGTSTSSEGRQYFQDIAKHKKDFVW 641

Query: 251 EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
           ++D D + IE+AFSKK+  DRK W+ NF+ G + D     I Y DF+NKELI FS ADL 
Sbjct: 642 KNDQDDNDIELAFSKKRITDRKEWLTNFQSGTHLDTEGKYIKYSDFINKELIQFSMADLL 701

Query: 311 RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
           RSIPS+VDGLKPGQRKILFCSFK+ L KEIKV QF GYVSEHSAYHHGEQSLASTI GMA
Sbjct: 702 RSIPSMVDGLKPGQRKILFCSFKRNLVKEIKVAQFSGYVSEHSAYHHGEQSLASTITGMA 761

Query: 371 QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
           QDFVGSNNINLL+PNGQFGTR+ GGKD AS+RYI+T L+PITR +F ++DD LL YL+ED
Sbjct: 762 QDFVGSNNINLLQPNGQFGTRDQGGKDAASARYIFTLLSPITRSIFPKDDDILLNYLDED 821

Query: 431 GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
           G+SIEP+WY+PI+P+VLVNGSEGIGTGWS++IPNYNPRDI+AN+RRLLNDE + PMDPWY
Sbjct: 822 GQSIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYNPRDIVANLRRLLNDEPVEPMDPWY 881

Query: 491 RGFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI 541
           RGFKG I+K+  + G   Y V G +E +D+ + RITELPIR+W+QDYK+FL SI
Sbjct: 882 RGFKGSIQKTGTKAGGVSYTVTGIIEVVDDTTLRITELPIRRWSQDYKEFLISI 935


>Q0PWB2_PLEOS (tr|Q0PWB2) DNA topoisomerase 2 OS=Pleurotus ostreatus GN=TopII PE=2
            SV=1
          Length = 1571

 Score =  822 bits (2122), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 406/738 (55%), Positives = 531/738 (71%), Gaps = 20/738 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I+D +L+WA FK  + +KKTDG+K  RL G+ KL DAN+AG +N++KCTLIL
Sbjct: 480  MKKVQKSSIIDQVLNWAKFKADQQIKKTDGSKRNRLTGMAKLSDANNAGTKNAEKCTLIL 539

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA+AGL+VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKI+GLQ N
Sbjct: 540  TEGDSAKSLAVAGLAVVGRDNFGVFPLRGKLLNVREARHDQIMKNEEIQNIKKIMGLQHN 599

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            KEY+NV SLRYG LMIM DQDHDGSHIKGLLINF+  F+PSLLKVP F+VEF TPI+R  
Sbjct: 600  KEYTNVSSLRYGRLMIMTDQDHDGSHIKGLLINFLDHFYPSLLKVPEFLVEFVTPIVRVT 659

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
              N  K +F+++PEYE+W E   + +  W  KYYKGLGTS+  + REYF  +GKH   F 
Sbjct: 660  KGNQRK-NFFTIPEYETWLEETPD-SKKWTAKYYKGLGTSSDADAREYFSQMGKHMIPFA 717

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
              +D + + I++AFSKKKA+DRK W R F+PG Y DH    I + DF+NKELILFS AD 
Sbjct: 718  TMEDEERALIDLAFSKKKADDRKEWQRQFKPGTYLDHNIDEIPFTDFINKELILFSMADN 777

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPSV DGLKPGQRK+++  FK+KL KEIKV Q +GY+SEH+AYHHGE SL+STI+ +
Sbjct: 778  IRSIPSVADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEMSLSSTIVNL 837

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQ++VGSNNINLL PNGQ+GTR+ GGKDHAS RYIYTE+ P+TR L   +DD LL+   +
Sbjct: 838  AQNYVGSNNINLLSPNGQYGTRDQGGKDHASPRYIYTEIAPLTRLLCRPSDDPLLKRQTD 897

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            D   +EP WY+PIIP+VLVNG+EGIGTGWS+ IP YNP DI+AN+RRL+N E +VPM PW
Sbjct: 898  DNLLVEPEWYLPIIPMVLVNGAEGIGTGWSTTIPCYNPVDIVANIRRLMNGEEVVPMLPW 957

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            +RGFKG ++  AK   Y V G  +++++ +  ITELPI KWTQ++K  LE +        
Sbjct: 958  WRGFKGEVKMVAKH-KYDVTGIAKKLNDTTVEITELPIYKWTQNFKAELEGMIGEK---G 1013

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
            D +++D+++  D+  V   + M  +++    Q+GL++ FKLTT I+TSNM  FD +GK+K
Sbjct: 1014 DGVVKDYKEYHDNLNVHYVVTMPAKELEKAEQQGLIEFFKLTTKINTSNMMCFDFDGKMK 1073

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY++PE+ILEEF+P+RL YY++RK ++    + +   L N+ RFI  +V  ++ VSNRKK
Sbjct: 1074 KYDSPEEILEEFYPVRLAYYQKRKDFLANELQTVFERLSNQARFIQMIVDKQLSVSNRKK 1133

Query: 670  ADLLMELQQKGFTPMPK--KGKSA---EPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRG 724
            AD++ +L++  F P PK  K K+A   E  V GA                          
Sbjct: 1134 ADIIQDLRKHQFRPFPKISKAKAAGELEEVVDGADEPAEEEEETGSGDSAT--------- 1184

Query: 725  DYEYLLSMSIGTLTLESV 742
            D++YLL M+I +LT E +
Sbjct: 1185 DFDYLLGMAIYSLTKEKI 1202


>E6R0Q0_CRYGW (tr|E6R0Q0) DNA topoisomerase 2 OS=Cryptococcus gattii serotype B
            (strain WM276 / ATCC MYA-4071) GN=CGB_B4210C PE=3 SV=1
          Length = 1377

 Score =  822 bits (2122), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 406/731 (55%), Positives = 524/731 (71%), Gaps = 18/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA +GI+D +L+WA FKQ + LKKTDGTK  R+ GIVKLEDAN+AGGRNS  CTLILTEG
Sbjct: 488  VAKTGIIDNVLNWARFKQDQILKKTDGTKRSRISGIVKLEDANNAGGRNSKNCTLILTEG 547

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL+VVGRD YGVFPLRGKLLNVREA + QI+ N EIQ+IK+ILGL+ N++Y
Sbjct: 548  DSAKALAVSGLAVVGRDEYGVFPLRGKLLNVREAGHDQIVKNVEIQHIKQILGLKHNQDY 607

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++V SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLL++P+F+VEF TPI++ +   
Sbjct: 608  ASVDSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVWKGK 667

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              ++SFY+MP+YE W+    NN  GW+ KYYKGLGTST  + ++YF DL KHR  F    
Sbjct: 668  -KEISFYTMPQYEEWKAQ-NNNGRGWESKYYKGLGTSTSADAKKYFGDLDKHRLAFETMQ 725

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I+MAF+KKKA+DRK W+R F+PG Y DH    +   DFVNKELILFS AD  RS
Sbjct: 726  PEDRQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDIQSLPISDFVNKELILFSMADNIRS 785

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSV DGLKPGQRK+LF  FK+ L KEIKV Q  GYVSE +AYHHGE SL STI+G+AQ+
Sbjct: 786  IPSVADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQN 845

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL PNGQFGTR  GGKD AS+RYI+T L  +TR +FH  DD LL YL EDG 
Sbjct: 846  FVGSNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLIEDGM 905

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP +++P +P+VL+NG++GIGTGWS+ IPNYNP DI+ N+RR++  E    M PW+RG
Sbjct: 906  SIEPDYFMPTVPMVLINGADGIGTGWSTAIPNYNPVDIVENLRRMMRGEEPEEMTPWFRG 965

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG IE+   +  Y V+G +E+I++ +  ITELPIR+WTQD+K+ LE +T G+  V    
Sbjct: 966  FKGSIER-IDQDKYKVSGKIEKINDTTLEITELPIRRWTQDFKEMLEEMTTGTDKVPQ-T 1023

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+ ++  D  V   + M  + +A   +EG  K+FKLTT++ T NM  FD  GKIKKY 
Sbjct: 1024 IKDYEEHHTDTTVHFRVHMTEKNLADAEKEGFDKRFKLTTSLGTGNMVCFDLNGKIKKYA 1083

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PE+ILEEFF  RL++Y  RKQ++ +   R    L N+ RF+  +++ E+VVS +++ D+
Sbjct: 1084 SPEEILEEFFHKRLEFYGHRKQHLADELNRQFERLSNQARFVHMIITKELVVSGKRRPDI 1143

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL+   F P PKK ++ E     A                       +  DY+YLL M
Sbjct: 1144 VAELRSLKFRPFPKKERAKEEGGNEA--------------AEEEEGDEGQASDYDYLLGM 1189

Query: 733  SIGTLTLESVQ 743
            +I +LT E V+
Sbjct: 1190 AIWSLTSEKVE 1200


>Q5KP97_CRYNJ (tr|Q5KP97) DNA topoisomerase 2 OS=Cryptococcus neoformans var.
            neoformans serotype D (strain JEC21 / ATCC MYA-565)
            GN=CNA03600 PE=3 SV=1
          Length = 1272

 Score =  821 bits (2120), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 405/731 (55%), Positives = 522/731 (71%), Gaps = 17/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA +GI+D +L+WA FKQ + LKKTDGTK  R+ GIVKLEDAN+AGGRNS  CTLILTEG
Sbjct: 489  VAKTGIIDNVLNWARFKQDQILKKTDGTKRSRISGIVKLEDANNAGGRNSKNCTLILTEG 548

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL+VVGRD YGVFPLRGKLLNVREA + QI+ N EIQ+IK+ILGL+ N++Y
Sbjct: 549  DSAKALAVSGLAVVGRDEYGVFPLRGKLLNVREAGHDQIVKNVEIQHIKQILGLKHNQDY 608

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +   SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLL++P+F+VEF TPI++ +   
Sbjct: 609  ATADSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVWKGK 668

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              ++SFY+MP+YE W+    NN  GW+ KYYKGLGTST  + ++YF DL KHR  F    
Sbjct: 669  -KEISFYTMPQYEEWKAQ-NNNGRGWESKYYKGLGTSTSADAKKYFSDLDKHRLAFETMQ 726

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I+MAF+KKKA+DRK W+R F+PG Y DH    +   DFVNKELILFS AD  RS
Sbjct: 727  PEDRQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDVQSLPISDFVNKELILFSMADNIRS 786

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSV DGLKPGQRK+LF  FK+ L KEIKV Q  GYVSE +AYHHGE SL STI+G+AQ+
Sbjct: 787  IPSVADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQN 846

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL PNGQFGTR  GGKD AS+RYI+T L  +TR +FH  DD LL YL EDG 
Sbjct: 847  FVGSNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLVEDGM 906

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP +++P +P+VL+NG++GIGTGWS+ IPNYNP DI+ N+RR++  E    M PW+RG
Sbjct: 907  SIEPDYFMPTVPMVLINGADGIGTGWSTAIPNYNPVDIVENLRRMMRGEEPEKMTPWFRG 966

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG IE+   +  Y V+G +E+I++ +  ITELPIR+WTQD+K+ LE +T G+  V    
Sbjct: 967  FKGFIER-IDQDKYKVSGIIEKINDTTLEITELPIRRWTQDFKEMLEEMTTGTDKVPQ-T 1024

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+ ++  D  V   + M  + +A   +EG  K+FKLTT++ T NM  FD  GKIKKY 
Sbjct: 1025 IKDYEEHHTDTTVHFRVHMTEKNLADAEKEGFDKRFKLTTSLGTGNMVCFDLNGKIKKYA 1084

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PE+ILEEFF  RL++Y  RKQ++ +   R    L N+ RF+  +++ E+VVS +++ D+
Sbjct: 1085 SPEEILEEFFHKRLEFYGHRKQHLADELNRQFERLSNQARFVHMIITKELVVSGKRRPDI 1144

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL+   F P PKK ++ E     A                       +  DY+YLL M
Sbjct: 1145 VAELRSLKFKPFPKKERAKEEGENEA-------------AEEEEDGDEGQASDYDYLLGM 1191

Query: 733  SIGTLTLESVQ 743
            +I +LT E V+
Sbjct: 1192 AIWSLTSEKVE 1202


>F5HDJ4_CRYNB (tr|F5HDJ4) DNA topoisomerase 2 OS=Cryptococcus neoformans var.
            neoformans serotype D (strain B-3501A) GN=CNBA3470 PE=3
            SV=1
          Length = 1272

 Score =  821 bits (2120), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 405/731 (55%), Positives = 522/731 (71%), Gaps = 17/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA +GI+D +L+WA FKQ + LKKTDGTK  R+ GIVKLEDAN+AGGRNS  CTLILTEG
Sbjct: 489  VAKTGIIDNVLNWARFKQDQILKKTDGTKRSRISGIVKLEDANNAGGRNSKNCTLILTEG 548

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL+VVGRD YGVFPLRGKLLNVREA + QI+ N EIQ+IK+ILGL+ N++Y
Sbjct: 549  DSAKALAVSGLAVVGRDEYGVFPLRGKLLNVREAGHDQIVKNVEIQHIKQILGLKHNQDY 608

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +   SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLL++P+F+VEF TPI++ +   
Sbjct: 609  ATADSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVWKGK 668

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              ++SFY+MP+YE W+    NN  GW+ KYYKGLGTST  + ++YF DL KHR  F    
Sbjct: 669  -KEISFYTMPQYEEWKAQ-NNNGRGWESKYYKGLGTSTSADAKKYFSDLDKHRLAFETMQ 726

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I+MAF+KKKA+DRK W+R F+PG Y DH    +   DFVNKELILFS AD  RS
Sbjct: 727  PEDRQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDVQSLPISDFVNKELILFSMADNIRS 786

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSV DGLKPGQRK+LF  FK+ L KEIKV Q  GYVSE +AYHHGE SL STI+G+AQ+
Sbjct: 787  IPSVADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQN 846

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL PNGQFGTR  GGKD AS+RYI+T L  +TR +FH  DD LL YL EDG 
Sbjct: 847  FVGSNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLVEDGM 906

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP +++P +P+VL+NG++GIGTGWS+ IPNYNP DI+ N+RR++  E    M PW+RG
Sbjct: 907  SIEPDYFMPTVPMVLINGADGIGTGWSTAIPNYNPVDIVENLRRMMRGEEPEKMTPWFRG 966

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG IE+   +  Y V+G +E+I++ +  ITELPIR+WTQD+K+ LE +T G+  V    
Sbjct: 967  FKGFIER-IDQDKYKVSGIIEKINDTTLEITELPIRRWTQDFKEMLEEMTTGTDKVPQ-T 1024

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+ ++  D  V   + M  + +A   +EG  K+FKLTT++ T NM  FD  GKIKKY 
Sbjct: 1025 IKDYEEHHTDTTVHFRVHMTEKNLADAEKEGFDKRFKLTTSLGTGNMVCFDLNGKIKKYA 1084

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PE+ILEEFF  RL++Y  RKQ++ +   R    L N+ RF+  +++ E+VVS +++ D+
Sbjct: 1085 SPEEILEEFFHKRLEFYGHRKQHLADELNRQFERLSNQARFVHMIITKELVVSGKRRPDI 1144

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL+   F P PKK ++ E     A                       +  DY+YLL M
Sbjct: 1145 VAELRSLKFKPFPKKERAKEEGENEA-------------AEEEEDGDEGQASDYDYLLGM 1191

Query: 733  SIGTLTLESVQ 743
            +I +LT E V+
Sbjct: 1192 AIWSLTSEKVE 1202


>J4ICG2_FIBRA (tr|J4ICG2) DNA topoisomerase 2 OS=Fibroporia radiculosa (strain TFFH
            294) GN=FIBRA_08613 PE=3 SV=1
          Length = 1571

 Score =  811 bits (2095), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 399/735 (54%), Positives = 523/735 (71%), Gaps = 12/735 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I+D +L+WA FK  + LKKTDG++  RL G+ KL DAN+AG R + +CTLIL
Sbjct: 474  MKKVQKSVIVDHILNWAKFKADQQLKKTDGSRRNRLSGLPKLSDANNAGTRKASECTLIL 533

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK LA+AGLSVVGRD+YGVFPLRGKLLNVR+A + QIM NEEIQNIKKILGLQ N
Sbjct: 534  TEGDSAKTLAVAGLSVVGRDNYGVFPLRGKLLNVRDAKHDQIMKNEEIQNIKKILGLQHN 593

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y +V  LRYG LMIM DQDHDGSHIKGLLIN+   F+PSLLKVP F+VEF TPIIRA 
Sbjct: 594  KDYKDVSGLRYGQLMIMTDQDHDGSHIKGLLINYFEHFYPSLLKVPHFLVEFVTPIIRA- 652

Query: 190  HSNGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
             + GT+L  FY++PEYE W E   N+A+ W+ KY KGLGTS  ++ R YF+ + KHR  F
Sbjct: 653  -TKGTQLIEFYTIPEYEQWLEETPNSAS-WRAKYLKGLGTSKDEDARRYFKLMRKHRIAF 710

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                + D  +IE+AFSKK+A+DRK W+R F+PG + DH    I + DF+N+ELILFS AD
Sbjct: 711  STIKEGDRDSIELAFSKKRADDRKEWLRQFKPGTFLDHTQGEIGFTDFINRELILFSMAD 770

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV DGLKP QRK+++  FK+KL  EIKV Q +G+VSEH+ YHHGEQSL  TI+ 
Sbjct: 771  NIRSIPSVADGLKPVQRKVIWACFKRKLKGEIKVAQLVGHVSEHAQYHHGEQSLMMTIVN 830

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQDFVG NN+NL+ PNGQFGTR+ GGKDHAS+RYIYTEL+P TR +FH  DD L++YL 
Sbjct: 831  LAQDFVGGNNLNLMMPNGQFGTRDQGGKDHASARYIYTELSPATRAVFHPGDDPLMKYLT 890

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP +Y+P +P+VL+NG+EGIGTGWS+ IP YNP DI+AN+RRL+  E  +PM P
Sbjct: 891  DDGHLIEPEYYMPTVPMVLINGAEGIGTGWSTNIPCYNPEDIVANLRRLMAGEEQLPMLP 950

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG I+K++ +  Y V+G V ++D+ +F ITELPI KWTQ+YK  LE++       
Sbjct: 951  WWRGFKGTIKKTS-DYRYDVSGIVTKLDDTTFEITELPIHKWTQNYKVELEAMCGEK--- 1006

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
             D  ++D+++  ++  V   + M+ + +     +GLL+ F+LT  I+TSNM  FD EGKI
Sbjct: 1007 GDGPVKDYKEYHNNMNVHFVVHMEPKAVEKAESQGLLEFFRLTGKINTSNMICFDFEGKI 1066

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            KKY  PE+I+E+F+P RL YY++RK ++       L  L+N++RFI  ++  E+ VSNRK
Sbjct: 1067 KKYNTPEEIIEDFYPQRLAYYQKRKDFMANELSDELDKLNNQIRFIQMIIDRELAVSNRK 1126

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            K D++ +L++K F P PK  K+     A A                          D++Y
Sbjct: 1127 KVDIVADLRKKEFRPFPKVSKAK----AKASETTELVEVNEDEEDEEDSGPAGSASDFDY 1182

Query: 729  LLSMSIGTLTLESVQ 743
            LL M+I +LT E ++
Sbjct: 1183 LLGMAIWSLTKEKME 1197


>K5XBZ3_PHACS (tr|K5XBZ3) DNA topoisomerase 2 OS=Phanerochaete carnosa (strain
            HHB-10118-sp) GN=PHACADRAFT_83842 PE=3 SV=1
          Length = 1551

 Score =  808 bits (2088), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 398/736 (54%), Positives = 521/736 (70%), Gaps = 19/736 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I+D +L+WA+ K  K+LKKTDG    R++G+ KL DAN+AG R +  CTLIL
Sbjct: 470  MKKVQKSSIIDQILNWANRKADKELKKTDGKGRNRIKGLTKLSDANNAGTRGAQNCTLIL 529

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA+AGLSV+GRD+YGVFPLRGKLLNVREA + QIM NEEIQNIKKILGLQ N
Sbjct: 530  TEGDSAKSLAVAGLSVIGRDNYGVFPLRGKLLNVREAKHDQIMKNEEIQNIKKILGLQHN 589

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y +   LRYG LMIM DQDHDGSHIKGL++N++  F+PSLLK+P F+VEF TPI+R  
Sbjct: 590  KDYKDTNDLRYGQLMIMTDQDHDGSHIKGLILNYLDHFYPSLLKIPKFLVEFVTPIVRVT 649

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
              N  K++F+++PEYE W EN  + +  WK KYYKGLGTS  ++ REYF  + KH   F 
Sbjct: 650  KGN-QKINFFTIPEYEQWLENTPD-SHKWKSKYYKGLGTSKDEDAREYFSRMNKHMIPFA 707

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
               D +   I++AFSKKKA+DRK W+RN EPG Y DH    I+  DF+N+ELILFS AD 
Sbjct: 708  TVKDGERDLIDLAFSKKKADDRKEWLRNLEPGTYLDHNTREISVSDFINRELILFSYADN 767

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPSV DGLKPGQRK+++  FK+KL  EIKV Q +GY+SE +AYHHGEQSL  TI+ +
Sbjct: 768  VRSIPSVADGLKPGQRKVIWGCFKRKLKNEIKVAQLVGYISEKAAYHHGEQSLMMTIVNL 827

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQDF+GSNN+NLL PNGQFGTR+ GGKDHAS+RYI+TE +P+ R L H  DD LL YL +
Sbjct: 828  AQDFIGSNNVNLLMPNGQFGTRDQGGKDHASARYIFTEPSPMARVLLHSGDDPLLNYLKD 887

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            D   IEP WY+P++PL+LVNG+EGIGTGWS+ +P YNP DI+AN+RR +N E MVPM PW
Sbjct: 888  DTTDIEPEWYMPVLPLILVNGAEGIGTGWSTNVPCYNPVDIVANIRRRMNGEEMVPMLPW 947

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT--DGSPN 547
            +RGF+G I+K+  +  Y V G + +ID+ +  ITELPI KWTQ+YKQ LE++    G   
Sbjct: 948  WRGFRGTIKKTG-DHKYDVTGIINKIDDTTVEITELPIHKWTQNYKQELETMMGEKGEGP 1006

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            VKD     +++  D+  V   + +  + +     +GL + FKLT  I+TSNM  FD +GK
Sbjct: 1007 VKD-----YKEYHDNMNVHFVVTLSEKDMEKAEAQGLYEFFKLTGKINTSNMICFDFDGK 1061

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            IKKY +PE+I+E+F+P+RL +Y++RK ++ E  +  L    N+ RFI  +VS E+VVS R
Sbjct: 1062 IKKYGSPEEIVEDFYPVRLAWYQKRKDHMAEQLQLELERSTNQARFISMIVSKELVVSGR 1121

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKAD++++L++K F P PK  K+   + AG                           DY+
Sbjct: 1122 KKADVIIDLRKKEFRPFPKISKA---KAAGETEEVVENGDEDEQEDNDGAH------DYD 1172

Query: 728  YLLSMSIGTLTLESVQ 743
            YLL+M+I +LT E ++
Sbjct: 1173 YLLNMAIYSLTKERIE 1188


>I2FWY2_USTH4 (tr|I2FWY2) DNA topoisomerase 2 OS=Ustilago hordei (strain Uh4875-4)
            GN=UHOR_05386 PE=3 SV=1
          Length = 1503

 Score =  808 bits (2087), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 400/731 (54%), Positives = 529/731 (72%), Gaps = 19/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  SG++D ++S+A +KQ + LKKTDG K  R+  I KLEDAN+AGGR +  CTLILTEG
Sbjct: 486  IIKSGVVDNIVSFARYKQDQALKKTDGHKRTRITNIPKLEDANNAGGRKAKDCTLILTEG 545

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGL  VGRD+YGVFPLRGKLLNVREA++ QIM N EI+ IK+I+GLQ  K+Y
Sbjct: 546  DSAKALAVAGLVEVGRDNYGVFPLRGKLLNVREATHDQIMKNAEIKAIKEIIGLQHGKQY 605

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYG +MIM DQDHDGSHIKGL+INF+  F+PSLLK+P+F+VEF TPI++   S 
Sbjct: 606  LDVSSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKLPNFLVEFITPIVKC--SK 663

Query: 193  GTK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            G K LSF+++PEY +W+E   +N  GW+IKYYKGLGTS  Q+ ++YFR + KH   F   
Sbjct: 664  GKKELSFFTIPEYMTWKE-ANSNGKGWRIKYYKGLGTSDSQDAKKYFRAMDKHMLPFDTT 722

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             D D   I++AF+KKKA+DRK W+R F PG Y DH   +I Y DF+NKELILFS AD  R
Sbjct: 723  KDGDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNIDKIPYADFINKELILFSMADNMR 782

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS VDGLKPGQRK++F +F +K   EIKV Q +G+VS  +AYHHGEQSL  TI+G+AQ
Sbjct: 783  SIPSAVDGLKPGQRKVIFGTFNRKGDGEIKVAQLVGHVSGTTAYHHGEQSLTMTIVGLAQ 842

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            +FVGSNN+NLL+P GQFGTR LGGKD AS+RYI+T L  ITR LF +NDD LLEYL++DG
Sbjct: 843  NFVGSNNVNLLEPRGQFGTRLLGGKDAASARYIFTALPKITRALFPQNDDALLEYLDDDG 902

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            +SIEP WY+P++P VL+NG+EGIGTGWS+++PNYNP DI+AN+RR +  E +VPM PWYR
Sbjct: 903  QSIEPQWYMPVVPQVLLNGAEGIGTGWSTFVPNYNPHDIVANLRRRMAGEDVVPMKPWYR 962

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            GF G IE+ A  G Y ++G V +IDE+++ ITELPIR WT  YK+ LE     +  V   
Sbjct: 963  GFTGDIEEFAP-GRYKLSGRVTQIDEKTYEITELPIRTWTSTYKESLEERILSTEKVPS- 1020

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I+D+++   ++ V   + +  +  A I ++G+   FK ++ IST+NM LFD +GKIKKY
Sbjct: 1021 TIKDYKEYHTESTVHFIVELNAKGQAEIAEKGVEAFFKTSSQISTTNMVLFDQDGKIKKY 1080

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
             +PE+ILE F+ LRL YY++RK+++++  + +   L N+ RF+  ++S +++VSNRK+AD
Sbjct: 1081 SSPEEILENFYLLRLSYYQKRKEHLVDQLKLMYDRLSNQARFVQMIISRQLIVSNRKRAD 1140

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ EL+QK F P PK GK+    VA                            DY+YLL+
Sbjct: 1141 IVAELRQKDFRPFPKSGKAT---VAAEIEDTDPIDDEEISSD----------SDYDYLLN 1187

Query: 732  MSIGTLTLESV 742
            M+I  LT E V
Sbjct: 1188 MAIYNLTKEKV 1198


>H3G7M6_PHYRM (tr|H3G7M6) DNA topoisomerase 2 (Fragment) OS=Phytophthora ramorum
            GN=gwEuk.69.30.1 PE=3 SV=1
          Length = 1174

 Score =  806 bits (2081), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 408/739 (55%), Positives = 519/739 (70%), Gaps = 30/739 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQ--RLRGIVKLEDANDAGGRNSDKCTLILT 70
            V  SG+++ +LS+A FKQ+ +L++  G   +  RL GI KL+DAN AG      CTLILT
Sbjct: 389  VEKSGMVEKILSFAAFKQTAELRRKGGGGGKRARLSGIPKLDDANHAGTAKGKDCTLILT 448

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK +A+ GL+VVGRD+YGVFPLRGK+LNVREAS+ QI+ NEEIQN+ KILGL+  +
Sbjct: 449  EGDSAKTVAVGGLAVVGRDYYGVFPLRGKMLNVREASHSQILKNEEIQNVVKILGLKYGQ 508

Query: 131  EYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
            +Y + K LRYGHLMIMADQDHDGSHIKGL+IN IH FWPSLL V  F+ EF TPI++   
Sbjct: 509  KYESTKGLRYGHLMIMADQDHDGSHIKGLVINLIHHFWPSLLVVEGFLQEFITPIVKCTK 568

Query: 191  SNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
               TK  FY+MPEYESWRE   N   GW IKYYKGLGTST  E +EYF DL  H+  F +
Sbjct: 569  GR-TKEVFYTMPEYESWRERT-NQGRGWVIKYYKGLGTSTAAETKEYFSDLQTHQIGFTY 626

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
            E D D   I+MAFSKK+ EDRK W+R +EPG Y D+    + Y +FVNKELILFS AD  
Sbjct: 627  EGDGDADVIDMAFSKKRVEDRKDWLRGYEPGTYVDYDVDAMGYTEFVNKELILFSMADNI 686

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPS++DG KP QRK+LFC FK+ L  E+KV Q  GYVSEHSAYHHGEQSL   I+ MA
Sbjct: 687  RSIPSILDGFKPSQRKVLFCCFKRNLRSELKVAQLAGYVSEHSAYHHGEQSLQGCIVNMA 746

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDFVGSNNI+LL P GQFGTR +GGKD AS+RYI+T L  +TR ++   D+ +L+YL+ED
Sbjct: 747  QDFVGSNNIHLLSPIGQFGTRLMGGKDSASARYIFTNLEQLTRLIYDPLDNDVLKYLDED 806

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+SIEP WYIPIIP+VLVNGS+GIGTGWSS +PNYNP DII  +R+++N E   P+ PWY
Sbjct: 807  GQSIEPEWYIPIIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEATPLTPWY 866

Query: 491  RGFKG-IIEKSAKEGG----YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            RGF G I+EK+   GG    Y+V G  E  DE +  I+ELP++ WTQ YKQFLE++ D +
Sbjct: 867  RGFTGHIVEKTNSRGGDTGNYVVQGLYEVTDESTLVISELPVKVWTQTYKQFLEALLDAN 926

Query: 546  PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFD 603
                   I+DF++N  D  V   I ++ + +  I +   G++KKFKL +++STSNMHLFD
Sbjct: 927  T------IKDFKENHTDVKVLFTITLEPKALTDISKAPGGIVKKFKLESSLSTSNMHLFD 980

Query: 604  AEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIV 663
            A G IKKYENP+Q+++EF+ +RL+YYERRK+ +L+  +  + +L NK RF+L VV G+++
Sbjct: 981  AAGHIKKYENPKQVMDEFYGVRLEYYERRKKAMLQKLKDQIKLLSNKARFVLSVVEGKLI 1040

Query: 664  VSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKR 723
            VSNRK+ DLL EL  +G+  +  K K        +                        R
Sbjct: 1041 VSNRKRQDLLEELISEGYDQILPKSKRKSSNDDDSNDEDEGNVTDAG------------R 1088

Query: 724  GDYEYLLSMSIGTLTLESV 742
            G Y+YLLSM I +LT E V
Sbjct: 1089 G-YDYLLSMKIWSLTKERV 1106


>F2U845_SALS5 (tr|F2U845) DNA topoisomerase 2 OS=Salpingoeca sp. (strain ATCC
            50818) GN=PTSG_04681 PE=3 SV=1
          Length = 1761

 Score =  805 bits (2080), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 405/733 (55%), Positives = 508/733 (69%), Gaps = 12/733 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKK-TDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            + ++GI+D +L+WA  K    L K + G+K  ++ GI KL+DAN+AGGRNS KCTLILTE
Sbjct: 401  IKDTGIVDAVLNWAKLKSQAQLSKASSGSKKCKISGIPKLDDANEAGGRNSSKCTLILTE 460

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAKALA++GL V+GRD+YGVFPLRGKLLNVREAS+KQIMDN E++NI KI+GL+   E
Sbjct: 461  GDSAKALAVSGLGVLGRDYYGVFPLRGKLLNVREASHKQIMDNAEVKNIAKIMGLKFGHE 520

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y+  K LRYG LMIM DQD DGSHIKGLLINFIH FWPSLLK+P F+VEF TPI++    
Sbjct: 521  YTTTKQLRYGRLMIMTDQDQDGSHIKGLLINFIHHFWPSLLKMPDFLVEFVTPIVKCTKG 580

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
               ++SF+++P+YE+W E  GN   GW+IKYYKGLGTSTPQE +EYF  +  H+  F +E
Sbjct: 581  K-QEVSFFTIPQYETWAEQQGN-LKGWRIKYYKGLGTSTPQEAKEYFSHMDDHQIPFSYE 638

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             D D   I MAFSKK  E RK W++NF PG Y DH    I Y DF+NKELILFS AD  R
Sbjct: 639  GDKDFEDIVMAFSKKHVEARKQWLKNFVPGTYLDHATDAICYSDFINKELILFSMADNVR 698

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS++DGLKPGQRK+LF  FK+KL  EIKV Q  GYVSEHSAYHHGE SLA TI+GMAQ
Sbjct: 699  SIPSIMDGLKPGQRKVLFSCFKRKLKDEIKVAQLAGYVSEHSAYHHGEMSLAGTIVGMAQ 758

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
             FVGSNN+NLL P GQFGTR  GGKD ASSRYI+T L+P+ R +FH  DD LL +L +DG
Sbjct: 759  RFVGSNNLNLLLPIGQFGTRLAGGKDAASSRYIFTSLSPLARKIFHLADDALLNHLEDDG 818

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            ++IEP +Y PI+P+VLVNGS+GIGTGWSS +PNYNPRD++  +  ++  +    + PWY 
Sbjct: 819  QTIEPEFYAPILPMVLVNGSDGIGTGWSSSVPNYNPRDLVNALIAMIEGQEPDELHPWYA 878

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT--DGSPNVK 549
            GF G I    K+  Y V GT++++DE +  I+ELPIR WTQ YK+FLE +   DG    K
Sbjct: 879  GFTGEITPKGKD-KYAVRGTLKKLDETTIEISELPIRTWTQPYKEFLEGLAADDGK---K 934

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
             P I +F Q   D  V   + M  E++     +GL K FKL  +ISTSNM LFD +G+IK
Sbjct: 935  PPQILEFSQYHTDTTVRFVVSMTPEQMQAAETKGLYKVFKLEGSISTSNMTLFDPQGRIK 994

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KYE  ++IL +FF +RL  Y++RK  + +        +DNKVRFIL V+SG +V+SNRKK
Sbjct: 995  KYEGVQEILRDFFDVRLRLYQKRKSLLADCMTSEYKKMDNKVRFILDVISGSLVISNRKK 1054

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            AD+L EL+ KGF   PK       +  G                           D++YL
Sbjct: 1055 ADILQELRAKGFAAFPKPKGKKGAKTVG---DLDDDAAGAPPSSDEDEALEESASDFDYL 1111

Query: 730  LSMSIGTLTLESV 742
            LSM +  LT+E V
Sbjct: 1112 LSMPMWNLTMERV 1124


>F2U844_SALS5 (tr|F2U844) DNA topoisomerase 2 OS=Salpingoeca sp. (strain ATCC
            50818) GN=PTSG_04681 PE=3 SV=1
          Length = 1795

 Score =  805 bits (2078), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 405/733 (55%), Positives = 508/733 (69%), Gaps = 12/733 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKK-TDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            + ++GI+D +L+WA  K    L K + G+K  ++ GI KL+DAN+AGGRNS KCTLILTE
Sbjct: 435  IKDTGIVDAVLNWAKLKSQAQLSKASSGSKKCKISGIPKLDDANEAGGRNSSKCTLILTE 494

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAKALA++GL V+GRD+YGVFPLRGKLLNVREAS+KQIMDN E++NI KI+GL+   E
Sbjct: 495  GDSAKALAVSGLGVLGRDYYGVFPLRGKLLNVREASHKQIMDNAEVKNIAKIMGLKFGHE 554

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y+  K LRYG LMIM DQD DGSHIKGLLINFIH FWPSLLK+P F+VEF TPI++    
Sbjct: 555  YTTTKQLRYGRLMIMTDQDQDGSHIKGLLINFIHHFWPSLLKMPDFLVEFVTPIVKCTKG 614

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
               ++SF+++P+YE+W E  GN   GW+IKYYKGLGTSTPQE +EYF  +  H+  F +E
Sbjct: 615  K-QEVSFFTIPQYETWAEQQGN-LKGWRIKYYKGLGTSTPQEAKEYFSHMDDHQIPFSYE 672

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             D D   I MAFSKK  E RK W++NF PG Y DH    I Y DF+NKELILFS AD  R
Sbjct: 673  GDKDFEDIVMAFSKKHVEARKQWLKNFVPGTYLDHATDAICYSDFINKELILFSMADNVR 732

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS++DGLKPGQRK+LF  FK+KL  EIKV Q  GYVSEHSAYHHGE SLA TI+GMAQ
Sbjct: 733  SIPSIMDGLKPGQRKVLFSCFKRKLKDEIKVAQLAGYVSEHSAYHHGEMSLAGTIVGMAQ 792

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
             FVGSNN+NLL P GQFGTR  GGKD ASSRYI+T L+P+ R +FH  DD LL +L +DG
Sbjct: 793  RFVGSNNLNLLLPIGQFGTRLAGGKDAASSRYIFTSLSPLARKIFHLADDALLNHLEDDG 852

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
            ++IEP +Y PI+P+VLVNGS+GIGTGWSS +PNYNPRD++  +  ++  +    + PWY 
Sbjct: 853  QTIEPEFYAPILPMVLVNGSDGIGTGWSSSVPNYNPRDLVNALIAMIEGQEPDELHPWYA 912

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT--DGSPNVK 549
            GF G I    K+  Y V GT++++DE +  I+ELPIR WTQ YK+FLE +   DG    K
Sbjct: 913  GFTGEITPKGKD-KYAVRGTLKKLDETTIEISELPIRTWTQPYKEFLEGLAADDGK---K 968

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
             P I +F Q   D  V   + M  E++     +GL K FKL  +ISTSNM LFD +G+IK
Sbjct: 969  PPQILEFSQYHTDTTVRFVVSMTPEQMQAAETKGLYKVFKLEGSISTSNMTLFDPQGRIK 1028

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KYE  ++IL +FF +RL  Y++RK  + +        +DNKVRFIL V+SG +V+SNRKK
Sbjct: 1029 KYEGVQEILRDFFDVRLRLYQKRKSLLADCMTSEYKKMDNKVRFILDVISGSLVISNRKK 1088

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            AD+L EL+ KGF   PK       +  G                           D++YL
Sbjct: 1089 ADILQELRAKGFAAFPKPKGKKGAKTVGDLDDDAAGAPPSSDEDEALEESA---SDFDYL 1145

Query: 730  LSMSIGTLTLESV 742
            LSM +  LT+E V
Sbjct: 1146 LSMPMWNLTMERV 1158


>M7NQN5_9ASCO (tr|M7NQN5) Uncharacterized protein OS=Pneumocystis murina B123
            GN=PNEG_00635 PE=4 SV=1
          Length = 1522

 Score =  803 bits (2075), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/674 (57%), Positives = 510/674 (75%), Gaps = 5/674 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + I++++L  A  K  + +KKTDG+K  R+ G+ KLEDAN AG +   KCTLILTEG
Sbjct: 501  VLKTSIMESILDTAQKKADQLMKKTDGSKKIRIIGLPKLEDANKAGTKEGHKCTLILTEG 560

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LAM+G+ VVGRD++GV+PLRGKLLNVREAS++QI  N EI  IK+I+GLQ  K Y
Sbjct: 561  DSAKSLAMSGIGVVGRDYFGVYPLRGKLLNVREASHEQITKNAEINAIKQIMGLQHKKVY 620

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++   LRYGHLMIM DQDHDGSHIKGL+IN++ S +PSLL++P F++EF TPI++A   +
Sbjct: 621  TSTSDLRYGHLMIMTDQDHDGSHIKGLIINYLESSFPSLLEIPGFLIEFITPIVKATKGS 680

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K +F+++PEYE W+E+  +NA GWKIKYYKGLGTS   + ++YF DL  H K+F    
Sbjct: 681  QEK-TFFTIPEYEYWKEST-DNAKGWKIKYYKGLGTSYGNDVKKYFSDLDTHLKEFHSIQ 738

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I+MAFSKKKA++RK W+R+F+PG Y DH   +I   DF+NKELILFS AD  RS
Sbjct: 739  EGDKELIDMAFSKKKADERKEWLRHFKPGTYMDHTLDKIPISDFINKELILFSMADNIRS 798

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDGLKPGQRK+++  FK+KL  EIKV Q  GY+SEH+AYHHGEQSL  TIIG+AQ 
Sbjct: 799  IPSVVDGLKPGQRKVIYGCFKRKLKSEIKVAQLSGYISEHTAYHHGEQSLTQTIIGLAQT 858

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINL+KPNGQFGTR  GGKD AS RYI+TEL+P+TR +F E+DD LL+YLN+DG+
Sbjct: 859  FVGSNNINLMKPNGQFGTRLQGGKDAASPRYIFTELSPLTRKIFIESDDALLDYLNDDGQ 918

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+PIIPL+LVNGSEGIGTGWSSYIPN+NP D++ N+RR++N E + PM PWYRG
Sbjct: 919  SIEPVWYVPIIPLILVNGSEGIGTGWSSYIPNFNPIDLVDNIRRMMNGEELRPMHPWYRG 978

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F GIIEK   +  Y ++G + +ID+ +  ITELPIR WTQD K+FLES   GS  ++ P 
Sbjct: 979  FNGIIEKHGDK--YKISGCIRQIDDTTVEITELPIRLWTQDMKEFLESSIVGSDKIQ-PF 1035

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+ +   D +V   I++  + +A  + +GL +KFKLT   + +NM  FDA G+IKKY+
Sbjct: 1036 IKDYSEYHTDTVVHFVIKLTEKGMAESLSQGLEEKFKLTKIQNMTNMVAFDASGRIKKYD 1095

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            + E+IL EF+ +RL +Y+RRK+Y++   E+    L N++RF+  V++ E    N+K+ DL
Sbjct: 1096 SVEEILLEFYTIRLQFYQRRKEYLVNELEKQYNKLSNQLRFVQMVINKEQEFLNKKRKDL 1155

Query: 673  LMELQQKGFTPMPK 686
            L +L+ KGFTP PK
Sbjct: 1156 LEDLKLKGFTPFPK 1169


>K8F0A4_9CHLO (tr|K8F0A4) DNA topoisomerase 2 OS=Bathycoccus prasinos
            GN=Bathy02g05900 PE=3 SV=1
          Length = 1444

 Score =  803 bits (2073), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 412/792 (52%), Positives = 526/792 (66%), Gaps = 18/792 (2%)

Query: 18   ILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKA 77
            +++ ++SWA FKQSKDLKKTDG K  RL GI KL+DAN+AGGRNS  CTLILTEGDSAKA
Sbjct: 430  LVENIMSWAQFKQSKDLKKTDGVKRLRLTGIPKLDDANNAGGRNSKDCTLILTEGDSAKA 489

Query: 78   LAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYS--NV 135
            LA++GLS+VGRD+YGVFPLRGKLLNVR+AS  Q+ +N EI +IK+ILGLQ  K Y   ++
Sbjct: 490  LAVSGLSIVGRDNYGVFPLRGKLLNVRDASFDQVKNNVEITHIKQILGLQHGKTYDEDSI 549

Query: 136  KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK 195
            K+LRYG LMIM DQDHDGSHIKGLLINF+H+ +PSLLK+P F++EF TPII+A     T+
Sbjct: 550  KTLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLLEFITPIIKATKGQQTR 609

Query: 196  LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYD 255
            + FY++PEYE+W+  + N+  GW IKYYKGLGTST +E +EYF  +  HRK F WE D D
Sbjct: 610  V-FYTLPEYENWKL-VNNDGKGWAIKYYKGLGTSTAKEAKEYFAAIELHRKTFCWESDGD 667

Query: 256  GSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPS 315
            G  I+M+FSKK+ EDRK W+  +E G + D     + Y +F+NKELILFS ADL RSIPS
Sbjct: 668  GDLIDMSFSKKRVEDRKRWLSAYEEGTFLDQSGETVRYDEFINKELILFSLADLMRSIPS 727

Query: 316  VVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVG 375
             +DG KP QRK++F  FK+KL  +IKV Q  GYVSEHSAYHHGE SLASTI+ +AQDFVG
Sbjct: 728  AIDGFKPSQRKVMFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLASTIVNLAQDFVG 787

Query: 376  SNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIE 435
            +NNINLL P+GQFGTR  GGKDHAS RYI+T L  + R +F E DD LL Y +EDG+ IE
Sbjct: 788  TNNINLLVPSGQFGTRLQGGKDHASPRYIFTRLAQLARVVFPECDDALLNYNDEDGQKIE 847

Query: 436  PSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKG 495
            P++Y+P+IP VL+NG+EGIGTGWS+ IPNYN RD+I+NVR +LN+E    M PWYR FKG
Sbjct: 848  PTYYMPVIPTVLINGAEGIGTGWSTSIPNYNARDVISNVRAILNEEEPTQMMPWYRHFKG 907

Query: 496  IIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLI 553
             I +   +G   +I  G+    DE +  ITELP+R WTQDYK+FLE +     + K P I
Sbjct: 908  EITEEIFKGERRFIATGSYHIRDECTLEITELPLRTWTQDYKEFLEELI-APKDKKAPFI 966

Query: 554  EDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYEN 613
             D+++   D  V   I M    +A   +EG++KKFKL + IS SNMH F+    I KYE+
Sbjct: 967  TDYKEYHTDTSVHFVITMPPANLAKAEEEGIVKKFKLASKISCSNMHAFNEHSIITKYES 1026

Query: 614  PEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLL 673
             E I++ F PLRL  YE R+Q +++  E  L  L NK RFIL VV G +VV+ +KKA+L+
Sbjct: 1027 AEDIMKSFVPLRLKAYEERRQMLIKVAESELKRLANKTRFILAVVEGSLVVNRKKKAELV 1086

Query: 674  MELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMS 733
             EL+   +  +PK   SA    A                             Y+YLLSM 
Sbjct: 1087 EELEMMMYDKLPKTKTSASAAAA---------IVQTDENDIAADESDDANASYDYLLSMP 1137

Query: 734  IGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMX--XXXXXXXXXXXQDGKEAEDEK 791
            +  LTLE V+                  T  K +W                D   AE+E 
Sbjct: 1138 LWNLTLEKVEDLVTEKEEKEAEVALLRGTTDKDLWFTDLDALEENLDQLEDDDVAAEEEM 1197

Query: 792  KRISQASKRTST 803
            ++  +A+ R +T
Sbjct: 1198 QKQVRAAARNNT 1209


>Q00XH2_OSTTA (tr|Q00XH2) DNA topoisomerase 2 OS=Ostreococcus tauri GN=Ot13g00110
            PE=3 SV=1
          Length = 1099

 Score =  801 bits (2068), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 392/657 (59%), Positives = 481/657 (73%), Gaps = 6/657 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            + +SG+++ ++SWA FKQSK+LKKTDG K  RL GI KL+DANDAGGRNS+ CTLILTEG
Sbjct: 424  LMDSGVVENIMSWAQFKQSKELKKTDGAKRSRLTGIPKLDDANDAGGRNSESCTLILTEG 483

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GLSVVGRD YGVFPLRGKLLNVR+AS+ QI +N EI NIK+ILGLQ  KEY
Sbjct: 484  DSAKALAVSGLSVVGRDKYGVFPLRGKLLNVRDASHDQIKNNAEINNIKQILGLQHGKEY 543

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + KSLRYG LMIM DQDHDGSHIKGLLINF+H+ +PSLLK+P F++EF TPII+A    
Sbjct: 544  DSAKSLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIPGFLLEFITPIIKATKGK 603

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             +K+ FY++PEYE+W+E     + GW IKYYKGLGTST  E +EYF  L  HRK+F+WE 
Sbjct: 604  QSKV-FYTLPEYETWKE-ANQGSAGWSIKYYKGLGTSTANEAKEYFASLDHHRKNFIWES 661

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D DG  I+M+FSKK+ EDRK W+  +EPG + D     I Y +F+NKELILFSRADL RS
Sbjct: 662  DGDGDLIDMSFSKKRVEDRKAWLNAYEPGTFLDMSGEAIRYDEFINKELILFSRADLLRS 721

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDG KP QRK+LF  FK+KL  +IKV Q  GYVSEHSAYHHGE SLA TI+ +AQD
Sbjct: 722  IPSMVDGFKPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLAMTIVNLAQD 781

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL P+GQFGTR  GGKDHAS RYI+T L+ I R +F E DD LL YL+EDG+
Sbjct: 782  FVGSNNINLLVPSGQFGTRLQGGKDHASPRYIFTRLHEICRAIFPECDDALLNYLDEDGQ 841

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP +Y P++PLVLVNG+EGIGTGWS+ IPN+NPRDII+N++ +L  E    M PWYR 
Sbjct: 842  RIEPDFYYPVLPLVLVNGAEGIGTGWSTSIPNFNPRDIISNIKLVLEGEEARQMHPWYRN 901

Query: 493  FKG-IIEKSAK-EGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            F G I+E+  K +  Y V G+    DE +  ITELP+R WT DYK FLE +       + 
Sbjct: 902  FNGSIVEEIVKGDSRYTVTGSYIIRDECTLEITELPLRSWTTDYKDFLEDMLAPKTKNEK 961

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFDAEGKI 608
            P I D+++   D  V   I M  E +A       G+ KKFKL+T +S SNMHLF+  G I
Sbjct: 962  PFITDYKEYHTDTTVHFVITMPPENLAAAQSAPGGIEKKFKLSTKVSISNMHLFNEHGAI 1021

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
             KY +P  +L+ F PLRL  Y +R+  ++   E  L  L NK+RFIL VV G +V S
Sbjct: 1022 TKYASPIDVLQAFIPLRLKAYAQRRDMLIRLAESQLKRLSNKMRFILAVVDGSLVNS 1078


>E9C0T0_CAPO3 (tr|E9C0T0) DNA topoisomerase 2 OS=Capsaspora owczarzaki (strain ATCC
            30864) GN=CAOG_01720 PE=3 SV=1
          Length = 1628

 Score =  801 bits (2068), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 393/736 (53%), Positives = 515/736 (69%), Gaps = 11/736 (1%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            A+ ++GI+  +L   + K  K+L K  G K+ ++ GI KL+DAN+AGGRNS +CTLILTE
Sbjct: 418  ALLSTGIVQAILDKNNEKLRKELDKISGRKSSKISGIAKLDDANEAGGRNSAQCTLILTE 477

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAKALA++GL +VGRD+YGVFPLRGKLLNVR+A++ QI +N+EI+++ KILGLQ NK+
Sbjct: 478  GDSAKALAVSGLGLVGRDYYGVFPLRGKLLNVRDAAHHQIRENQEIEHVIKILGLQFNKK 537

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y++V+ LRYG LMIM DQD DGSHIKGLLINF+H FWPSLL V  F+VEF TPI++A   
Sbjct: 538  YTSVEGLRYGRLMIMTDQDSDGSHIKGLLINFLHHFWPSLLTVSGFLVEFITPIVKATKG 597

Query: 192  NGTKLSFYSMPEYESWRE-NLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
                L+F+++P+Y+ WRE + G    GW IKYYKGLGTST QE +EYF ++  H+  F W
Sbjct: 598  KQV-LTFFTVPQYQQWREEDDGRACKGWTIKYYKGLGTSTSQEAKEYFSNMDVHQIPFTW 656

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
              + DG AI++AFSKK+A+DRK W+R F  G + DH    I Y +F+NKELILFS AD  
Sbjct: 657  SGEDDGQAIDLAFSKKRADDRKEWLRQFRAGTFLDHQTEAITYSEFINKELILFSMADNV 716

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPSVVDG KP QRK+LF  FK+ L  EIKV Q  GYV+EHSAYHHGE SLA TI+ MA
Sbjct: 717  RSIPSVVDGFKPSQRKVLFACFKRNLKDEIKVAQLAGYVAEHSAYHHGEVSLAGTIVNMA 776

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q++ GSNNINLL P GQFGTR  GGKD AS+RYI+T+L  +TR +F  NDD LL YL+ED
Sbjct: 777  QNYTGSNNINLLLPLGQFGTRLQGGKDAASARYIFTKLATLTRLIFPANDDSLLNYLDED 836

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+ IEP WY+PI+PL L+NG EGIGTGWSS +PN++PRD++AN+R ++  +   PM P+Y
Sbjct: 837  GQRIEPEWYMPILPLSLINGCEGIGTGWSSSVPNFSPRDVVANIRLMMAGQDPEPMCPYY 896

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
             GF G IE   K   + V G + ++   +  ITELPI  WTQ YK+ LE + +  PN KD
Sbjct: 897  NGFTGTIEPLGKADRFRVCGRITKLSATTLEITELPIGVWTQSYKEELEKLME--PNEKD 954

Query: 551  P---LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
                 I+DFR+N  D  V   + +  E +A     GL KKFK+ +TIST+NM  FDAEG+
Sbjct: 955  KTPGFIKDFRENHTDTSVHFTVTLSEENMAAAEAMGLAKKFKIDSTISTANMVFFDAEGR 1014

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            IKKY++P+ IL +F+ LRL YY++RK +++E        LDNKVRFI  V+ G++V+SNR
Sbjct: 1015 IKKYDSPQAILRDFYDLRLKYYQKRKSWLVERLTEEWTRLDNKVRFIQAVIKGDLVISNR 1074

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            K+ADL+ +L+ +G+T      K    ++AGA                           Y+
Sbjct: 1075 KRADLMRDLKTRGYTAFSTSTKKI--KIAGAIDADDNGGADETADNDSDDIVHT--NGYD 1130

Query: 728  YLLSMSIGTLTLESVQ 743
            YLL+M + +LTLE VQ
Sbjct: 1131 YLLTMPLWSLTLEKVQ 1146


>G5AAW7_PHYSP (tr|G5AAW7) DNA topoisomerase 2 (Fragment) OS=Phytophthora sojae
            (strain P6497) GN=PHYSODRAFT_565596 PE=3 SV=1
          Length = 1289

 Score =  800 bits (2065), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 417/811 (51%), Positives = 532/811 (65%), Gaps = 36/811 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKT--QRLRGIVKLEDANDAGGRNSDKCTLILT 70
            V  SG+++ +LS+A FKQ+ +L++  G      RL GI KL+DAN AG   S  CTLILT
Sbjct: 501  VEKSGLVEKILSFAAFKQTAELRRKGGGGGKRSRLTGIPKLDDANHAGTAKSKDCTLILT 560

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK +A+ GL+VVGRD+YGVFPLRGK+LNVREAS+ QI+ NEEIQN+ KILGL+  +
Sbjct: 561  EGDSAKTVAVGGLAVVGRDYYGVFPLRGKMLNVREASHSQILKNEEIQNVVKILGLKYGQ 620

Query: 131  EYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
            +Y + K LRYGHLMIMADQDHDGSHIKGL+IN IH FWPSLL V  F+ EF TPI++   
Sbjct: 621  KYESTKGLRYGHLMIMADQDHDGSHIKGLVINLIHHFWPSLLLVDGFLQEFITPIVKC-- 678

Query: 191  SNG-TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
            S G TK  FY+MPEYE+WRE   N   GW IKYYKGLGTST  E +EYF DL  H+  F 
Sbjct: 679  SKGRTKEVFYTMPEYEAWRERT-NQGRGWVIKYYKGLGTSTAAETKEYFSDLRTHQIGFT 737

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
            +  + D   I+MAFSKK+ EDRK W+R +EPG Y D+    + Y DFVNKELILFS AD 
Sbjct: 738  YGGEGDADVIDMAFSKKRVEDRKEWLRGYEPGTYVDYDVDEMGYTDFVNKELILFSMADN 797

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPS+VDG KP QRK+LFC FK+ L  E+KV Q  GYVSEHSAYHHGE SL   I+ M
Sbjct: 798  IRSIPSIVDGFKPSQRKVLFCCFKRNLRSELKVAQLAGYVSEHSAYHHGEASLQGCIVNM 857

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQDFVGSNN++LL P GQFGTR +GGKD AS+RYI+T L  +TR ++   D+ +L+YL+E
Sbjct: 858  AQDFVGSNNVHLLSPIGQFGTRLMGGKDAASARYIFTNLEQLTRRIYDPLDNDVLKYLDE 917

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            DG+SIEP WYIP+IP+VLVNGS+GIGTGWSS +PNYNP DII  +R+++N E   P+ PW
Sbjct: 918  DGQSIEPEWYIPVIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEASPLTPW 977

Query: 490  YRGFKG-IIEKS----AKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDG 544
            YRGF G I+EK+       G YIV G  E  D+ +  I+ELP++ WTQ YKQFLE + + 
Sbjct: 978  YRGFTGHIVEKTNSRGTDTGNYIVQGLYEVTDDSTLVISELPVKTWTQSYKQFLEGLLET 1037

Query: 545  SPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMI--MQEGLLKKFKLTTTISTSNMHLF 602
                    I+DF++N  D  V   I ++ + ++ I   Q G++KKFKL +++STSNMHLF
Sbjct: 1038 GT------IKDFKENHTDVKVLFTITLEPKTLSDIAKTQGGIVKKFKLESSLSTSNMHLF 1091

Query: 603  DAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEI 662
            DA G IKKYENP++I+EEF+ +RLDYY RRK+ +L+     + +L NK RF+L VV G++
Sbjct: 1092 DAAGHIKKYENPKEIMEEFYGIRLDYYGRRKEAMLQKLRDQIKLLSNKARFVLSVVEGKL 1151

Query: 663  VVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXK 722
            VV+NRKK +LL EL  +G+            Q+A                          
Sbjct: 1152 VVNNRKKQELLEELIAEGYD-----------QIAPKTKKKSDSEDSNESEEEDINVADAS 1200

Query: 723  RGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQ 782
            RG Y+YLLSM I +LT E V                      + +W+             
Sbjct: 1201 RG-YDYLLSMKIWSLTKERVDNLRAELQEREQEYTVLEGRTVRDLWLTDLDALEKMIT-- 1257

Query: 783  DGKEAEDEKKRISQASKRTSTRDLGTKAAKK 813
               E E +++RI   + +  TR     A KK
Sbjct: 1258 ---ETEAQRERILSHTPKKKTRAAPKSATKK 1285


>L1IRG4_GUITH (tr|L1IRG4) DNA topoisomerase 2 OS=Guillardia theta CCMP2712
            GN=GUITHDRAFT_158481 PE=3 SV=1
          Length = 1343

 Score =  799 bits (2063), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 388/732 (53%), Positives = 524/732 (71%), Gaps = 15/732 (2%)

Query: 18   ILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKA 77
            I+D +LS+   KQ KD+KKTDG KT R+ GI KLEDANDAG +++  CTLILTEGDSAKA
Sbjct: 403  IIDGILSFGQEKQEKDMKKTDGKKTGRIVGIPKLEDANDAGTKHAADCTLILTEGDSAKA 462

Query: 78   LAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN-VK 136
            LA++GL+VVGR+ YGVFPLRGK+ N R+A+++QIM NEEI+N+K ILGLQQ  +Y N  +
Sbjct: 463  LAVSGLAVVGRNRYGVFPLRGKVANPRDANHEQIMKNEEIKNLKTILGLQQGNKYENGPQ 522

Query: 137  SLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNG--T 194
             LRYGH+MIMADQD DGSHIKGLLIN  H +WP+LL+ P F+ EF TPI++A    G   
Sbjct: 523  GLRYGHVMIMADQDPDGSHIKGLLINLFHYYWPNLLRHPGFLQEFATPIVKAKKKGGGKN 582

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
            +++F+++ EYE WRE +G+   GW IKYYKGLGTS+ QE +EYF +L  H+ DF WE   
Sbjct: 583  EIAFFTLQEYEEWREQVGDGLGGWTIKYYKGLGTSSSQEAKEYFSNLPLHQMDFAWEGAE 642

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            DG  I+M FSKK+A+DRK W+  +E   + DH  S + Y DF+NKELI FS  D  RSIP
Sbjct: 643  DGEIIDMVFSKKRADDRKQWLLRYEEDLFVDHNGSEVTYSDFINKELIHFSMMDNMRSIP 702

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S+VDG KPGQRKIL+  FK+KL  EIKV Q  GYV+EHSAYHHGEQSLA  I+GMAQ+FV
Sbjct: 703  SLVDGWKPGQRKILYACFKRKLKAEIKVAQLAGYVAEHSAYHHGEQSLAMAIVGMAQNFV 762

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNN+N+L P+GQFGTR  GG D AS RYI+T L+PITR LFHE DD +L+YLN+DG+SI
Sbjct: 763  GSNNVNVLVPSGQFGTRLQGGADAASPRYIFTYLHPITRFLFHEADDAILKYLNDDGQSI 822

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP +Y+PI+P VLVNG+ GIGTGWS+ +P YNPRD+++N++RLL  E M PM PW+RGF+
Sbjct: 823  EPQFYVPILPTVLVNGAHGIGTGWSTDVPCYNPRDVVSNLKRLLRQEVMEPMHPWFRGFQ 882

Query: 495  GIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G +E +  + G   Y + G  E++DE +  I ELP+ KWTQ YK+FLE++ D     K+P
Sbjct: 883  GSVELNVSKKGEVSYTLVGKWEKVDETTLVINELPVGKWTQQYKEFLETLMDTEGGKKEP 942

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I+ +R+   D  V  E+ M  +++    + G+ KKF+L+ +++ SNMHLF+A+G+I++Y
Sbjct: 943  FIKGYREYHTDTTVYFEVSMTEKRMEEAEEVGIAKKFQLSRSLAISNMHLFNADGQIQRY 1002

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
            ++PEQI+ EF+ +R+++Y +RK+ +     + L VLDNK RFI  V++G + V+NRKK +
Sbjct: 1003 DSPEQIMREFYGVRMEHYRQRKEQLEGELGKQLKVLDNKCRFIKEVIAGTLKVNNRKKTE 1062

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ +L  +G+ P+ K+GK    +                             G Y+YLL+
Sbjct: 1063 IVQDLSARGYMPLYKEGKKKAAEGEEQEGEAQEQEQQEGKGSS---------GGYDYLLN 1113

Query: 732  MSIGTLTLESVQ 743
            M I +LTLE V+
Sbjct: 1114 MPILSLTLERVK 1125


>M2RR97_CERSU (tr|M2RR97) DNA topoisomerase 2 OS=Ceriporiopsis subvermispora B
            GN=CERSUDRAFT_109994 PE=3 SV=1
          Length = 1522

 Score =  798 bits (2062), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 389/733 (53%), Positives = 517/733 (70%), Gaps = 17/733 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I++ +L+WA FK  + +KKTDG++  RL G+ KL DAN+AG + + +CTLIL
Sbjct: 473  MKKVQKSAIIEHILNWAKFKADQQMKKTDGSRRTRLTGLPKLSDANNAGSKKASECTLIL 532

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA+AGL VVGRD++GVFPLRGKLLNVR+A + QIM NEEIQNIKKILGLQ N
Sbjct: 533  TEGDSAKSLAVAGLGVVGRDNFGVFPLRGKLLNVRDAKHDQIMKNEEIQNIKKILGLQHN 592

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y +   LRYG LMIMADQDHDGSHIKGLL+N++  F+PSLLK+P F +EF TPI+R  
Sbjct: 593  KDYKDAGQLRYGKLMIMADQDHDGSHIKGLLLNYLDHFYPSLLKIPGFFLEFITPIVRVS 652

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
              +  K+ F+++PEY+ W EN  N+ T WK+KYYKGLGTS   + REYF+++ KH   F 
Sbjct: 653  KGD-KKVDFFTVPEYQQWVENTPNSHT-WKVKYYKGLGTSVDSDAREYFKNMRKHMIPFA 710

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
              ++ D   IEMAFSKKKA++RK W+R F PG + +H   +I + DF+N+ELILFS AD 
Sbjct: 711  PTEEGDHELIEMAFSKKKADERKEWLRQFRPGTFLNHDQRQIKFSDFINRELILFSMADN 770

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPSV DGLKPGQRK+L+  FK+ L  EIKV Q +GYVSEH+ YHHGE SL  TI+ +
Sbjct: 771  IRSIPSVADGLKPGQRKVLWSCFKRGLKSEIKVAQLVGYVSEHAQYHHGEMSLMQTIVNL 830

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQDFVGSNN+N+L PNGQFGTR+ GGKDHAS+RYI+TE +PITR +FH  DD L+ +  E
Sbjct: 831  AQDFVGSNNMNILMPNGQFGTRDQGGKDHASARYIFTEPSPITRKVFHPADDPLMNFQTE 890

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            D   +EP +Y+P++P++L+NG+EGIGTGWS+ +P+YNP DI+AN+RRL+  E  VPM PW
Sbjct: 891  DNHVVEPDYYLPVLPMILINGAEGIGTGWSTSVPSYNPEDIVANIRRLMAGEEQVPMLPW 950

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            +RGFKG I+K   E  Y V G V ++D+ +  ITELPI KWTQ+YK  LE++        
Sbjct: 951  WRGFKGTIKKVG-EHKYDVLGVVNKLDDTTVEITELPIHKWTQNYKAELEAMCGEK---G 1006

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
            D +I+D++++ D+  V   I M    +    Q+GL + FKLT  I+TSNM  FD +G+I+
Sbjct: 1007 DGVIKDYKEHHDNMNVHFVINMTANDLEKAEQQGLQEFFKLTGKINTSNMICFDFDGQIR 1066

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY +PE+I+EE++P RL YY++RK Y+    +  L  L N+ RF+  +V  E+VVSNRKK
Sbjct: 1067 KYNSPEEIVEEYYPKRLAYYQKRKDYLANELQLQLDRLSNQARFVKMIVDRELVVSNRKK 1126

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
             D++ EL++  F P PK  K+   + AG                           DY+YL
Sbjct: 1127 IDIVAELRKLEFRPFPKVAKA---KAAGETEDALEDEDDTSPNAATT--------DYDYL 1175

Query: 730  LSMSIGTLTLESV 742
            L M+I +LT E +
Sbjct: 1176 LGMAIYSLTKEKI 1188


>R7SSV1_DICSQ (tr|R7SSV1) Type II DNA topoisomerase OS=Dichomitus squalens (strain
            LYAD-421) GN=DICSQDRAFT_156586 PE=4 SV=1
          Length = 1540

 Score =  798 bits (2060), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/738 (52%), Positives = 513/738 (69%), Gaps = 21/738 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  VA S I+D +L+WA FK  + LKKTDG +  R+ G+ KL DAN+AG + + +CTLIL
Sbjct: 476  MKKVAKSSIVDHVLNWAKFKADQQLKKTDGNRRSRITGMTKLCDANNAGTKKAGECTLIL 535

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAKALA+AGL VVGRD YGVFPLRGKLLNVR+A + QIM NEEIQNIKKILGLQ N
Sbjct: 536  TEGDSAKALAIAGLGVVGRDSYGVFPLRGKLLNVRDAKHDQIMKNEEIQNIKKILGLQHN 595

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K Y++   LRYG LM+M DQDHDGSHIKGLLIN++  F+PSLLK+P F+VEF TP++R +
Sbjct: 596  KTYTDTAGLRYGRLMLMTDQDHDGSHIKGLLINYLDHFYPSLLKLPKFLVEFITPVVRVW 655

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
                  ++FY++PEYE W E   ++   W+ KYYKGLGTS  ++ R+YFRD+ +H   F 
Sbjct: 656  KGKQV-INFYTIPEYEMWLEQTPDSHK-WQHKYYKGLGTSKDEDARDYFRDMKRHMIPFS 713

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
               + D   IE+AFSKKKA+DRK W+R F+PG Y DH    I   +F+N+ELILFS AD 
Sbjct: 714  TSKEGDRELIELAFSKKKADDRKEWLRQFKPGTYLDHTQREIPLSEFINRELILFSMADN 773

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPSV DGLKPGQRK+++  FK+ L KEIKV Q +GYVSE SAYHHGE SL +TII +
Sbjct: 774  IRSIPSVADGLKPGQRKVIWSCFKRNLKKEIKVAQLVGYVSEVSAYHHGEASLMATIINL 833

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQDFVGSNNINLL PNGQFGTR+ GGKDHA++RYI+TEL PI R L H  DD +L Y  +
Sbjct: 834  AQDFVGSNNINLLMPNGQFGTRDQGGKDHAAARYIFTELAPIVRTLMHPADDAILTYQQD 893

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            DGR +EP WY+PI+P+VLVNG+EGIGTGWS+ IP YNP DI+AN+RRL+N+E   PM PW
Sbjct: 894  DGRQVEPEWYMPIVPMVLVNGAEGIGTGWSTTIPAYNPEDIVANIRRLMNNEEQEPMLPW 953

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT----DGS 545
            +RGF G ++K   +  Y V GT  ++D+ +  ITELPI +WTQ++K  LE++     DGS
Sbjct: 954  WRGFSGTVKKVG-DNKYDVIGTCTKLDDTTVEITELPIHRWTQNFKAELEAMIGEKGDGS 1012

Query: 546  PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
                   ++D+ ++ ++  V   + M  + +    ++G  + FKL+T I+TSNM  FD +
Sbjct: 1013 -------VKDYEEHHNNMNVHFIVTMSAKGMEEAEKQGFHEYFKLSTKINTSNMVCFDFD 1065

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            GKIKKY  PE+I+E+F+P RL YY++RK Y++   E  L  L+N+ RF+  ++  E+ VS
Sbjct: 1066 GKIKKYNAPEEIIEDFYPKRLAYYQKRKDYLVNELEVQLDKLNNQARFVKMIIDRELSVS 1125

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
            NR+KAD++ +L+ K F P PK  K+                                  D
Sbjct: 1126 NRRKADIVQDLRNKQFRPFPKVAKAKAAGETEDVVEEEDEDGEAGGPAGNL-------SD 1178

Query: 726  YEYLLSMSIGTLTLESVQ 743
            ++YLL M+I +LT E ++
Sbjct: 1179 FDYLLGMAIWSLTKEKIE 1196


>E3JRR8_PUCGT (tr|E3JRR8) DNA topoisomerase 2 OS=Puccinia graminis f. sp. tritici
            (strain CRL 75-36-700-3 / race SCCL) GN=PGTG_00741 PE=3
            SV=2
          Length = 1613

 Score =  797 bits (2058), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 392/733 (53%), Positives = 511/733 (69%), Gaps = 9/733 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  SG++D+++ +A FK+   LKKTDG+K  R+ GIVKLEDAN+AG R +  CTLIL
Sbjct: 497  MKKVMKSGVIDSVMDFAKFKEEAALKKTDGSKRSRITGIVKLEDANNAGTRKAADCTLIL 556

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA+AGLSV+GRD+YGVFPLRGKLLNVREAS  Q+++N EIQ+IK+I+GLQQ 
Sbjct: 557  TEGDSAKSLAVAGLSVIGRDNYGVFPLRGKLLNVREASGAQLLNNAEIQHIKQIMGLQQG 616

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y++  SLRYG LMIM DQDHDGSHIKGL+INF+  F+PSLL++P F+VEF TPI++  
Sbjct: 617  KKYASRDSLRYGSLMIMTDQDHDGSHIKGLIINFLDYFFPSLLEIPGFLVEFITPIVKVT 676

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
                 +LSF++MPE+E W+E   ++  GW  KYYKGLGTS  ++ ++YF  +  HR  F 
Sbjct: 677  RKK-EELSFFTMPEFEKWKEE-NDDGRGWTSKYYKGLGTSDAKDAKKYFSRMSSHRIKFA 734

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
               + D   I+MAF+KKKA+DRK W+R FEPG + D   S+I Y +F+NKELILFS AD 
Sbjct: 735  PTQENDRHLIDMAFNKKKADDRKEWLRGFEPGTHLDQNVSQITYTEFINKELILFSMADN 794

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPS+VDG KPGQRK+LF  FK+KL  EIKV Q  GY SEHSAYHHGE SL  TI+G+
Sbjct: 795  IRSIPSMVDGFKPGQRKVLFACFKRKLKAEIKVAQLGGYCSEHSAYHHGEASLTQTIVGL 854

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQ+FVGSNNIN+L PNGQFGTR  GGKD AS+RYI+T +  ITR +F   DD +L YL +
Sbjct: 855  AQNFVGSNNINVLSPNGQFGTRASGGKDAASARYIFTNVEKITRVIFPPADDNVLNYLTD 914

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            DG  IEP WYIPI+P+VLVNGS GIGTGWSS IPNYNP DI+ N+RR L +E M PM PW
Sbjct: 915  DGTQIEPEWYIPILPMVLVNGSSGIGTGWSSDIPNYNPVDIVNNLRRRLANEPMEPMHPW 974

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            +RGF G I   A  G Y V G  ++ DE +  ITELP+R W Q YK+ +E+  + +  + 
Sbjct: 975  FRGFTGQITSEA-PGKYKVLGEWDQPDEDTIEITELPVRVWNQSYKEQIEAWINSTDKIP 1033

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
              L++D+R+   +  V   I +       I +EG+ K FKL+  +S +NM  FD  GKIK
Sbjct: 1034 -ALVKDYREYHTETTVHFIISLTERGKDAIKKEGIEKVFKLSANLSITNMVCFDPSGKIK 1092

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY  PEQIL++F+ +RL YY++RK+Y++ +   +   L N+ RF+L ++  ++VVSNRKK
Sbjct: 1093 KYSTPEQILDDFYDVRLAYYQKRKEYLVNDLTLMYERLSNQARFVLMIIEKKLVVSNRKK 1152

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            A+++ EL++  F P P K K   P+ AG                          GD++YL
Sbjct: 1153 AEIVAELRKLEFRPFPVKAK---PKTAGDPDQADEEGVEEEEVADLKAAGTA--GDFDYL 1207

Query: 730  LSMSIGTLTLESV 742
            L M+I  LT E V
Sbjct: 1208 LGMAISRLTAEQV 1220


>A1IGC8_COPCI (tr|A1IGC8) DNA topoisomerase 2 OS=Coprinopsis cinerea GN=topII PE=2
            SV=1
          Length = 1569

 Score =  795 bits (2054), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 395/750 (52%), Positives = 520/750 (69%), Gaps = 33/750 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI+D +L+WA FK  + +K+ DGTK  RL G+ KL DAN+AG R++  CTLILTEG
Sbjct: 481  VAKSGIVDNVLNWAKFKADQQMKRADGTKRSRLLGLAKLSDANNAGTRHAQDCTLILTEG 540

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGL VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKI+GLQ NK+Y
Sbjct: 541  DSAKALAIAGLGVVGRDNFGVFPLRGKLLNVREARHDQIMKNEEIQNIKKIMGLQHNKDY 600

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +N  SLRYG LMIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+VEF TPI+R    N
Sbjct: 601  TNTSSLRYGRLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPDFLVEFVTPIVRVKKGN 660

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K  F+++PEYE W E    +A  W+ KYYKGLGTS  ++ REYF  + KH   F    
Sbjct: 661  KVK-DFFTIPEYEQWLEE-APDARKWESKYYKGLGTSEDKDAREYFSKMEKHMIPFAPTQ 718

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I++AFSKKKA++RK W+R F+PG + DH    I Y +F+NKELILFS AD  RS
Sbjct: 719  EGDRELIDLAFSKKKADERKEWLRQFKPGTFLDHRLEEIPYSEFINKELILFSMADNVRS 778

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+ DGLKPGQRK+++  FK+KL KEIKV Q +GY+SEH+AYHHGE SLA+TII +AQD
Sbjct: 779  IPSIADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAATIINLAQD 838

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNN+ LL PNGQ+GTR +GGKDHA+ RYI+T    ITR ++H  DD LL YL +D  
Sbjct: 839  YVGSNNLALLSPNGQYGTREIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKDDDV 898

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP WY+P +P+VL+NG+EGIGTGWS+ IP YNP DI+AN+RR++ +E   PM PW+RG
Sbjct: 899  PIEPEWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEEPEPMTPWWRG 958

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN----- 547
            FKG +  + K G Y V G   +I++ +  I+ELPI KWT+ +K  LE++  G        
Sbjct: 959  FKGEVRPTGK-GKYDVVGVATKINDTTVEISELPIHKWTRTFKDELEAMITGEKKDKDKD 1017

Query: 548  -----------VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTIS 595
                       VK+  +++DF+++ D+  V  E+ M  + +    ++GL++ F LTT +S
Sbjct: 1018 KDKDEDGKKDVVKNAGMVKDFKEHHDNLNVLFEVTMNPKDLEKAEEKGLVEFFGLTTKVS 1077

Query: 596  TSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFIL 655
            T+NM LFD EGKIKKYE PE+IL++F+P+RL YY++RK Y           L+N++RFI 
Sbjct: 1078 TTNMILFDFEGKIKKYETPEEILKDFYPMRLAYYQKRKDYQALELSTAYDKLNNQIRFIE 1137

Query: 656  GVVSGEIVVSNRKKADLLMELQQKGFTPMPK--KGKSAEPQVAGAXXXXXXXXXXXXXXX 713
             ++  E+VVSNRKKAD++ EL++  F P PK  K K+A+P                    
Sbjct: 1138 MIIKKELVVSNRKKADIVAELRKLNFRPFPKVAKTKTAKPDEEEEESEDEEEESGSEAVT 1197

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                       D++YLL M+I +LT E ++
Sbjct: 1198 -----------DFDYLLGMAIYSLTRERIE 1216


>Q5KSK9_COPCI (tr|Q5KSK9) DNA topoisomerase 2 OS=Coprinopsis cinerea GN=CoTopII
            PE=2 SV=1
          Length = 1572

 Score =  795 bits (2052), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 395/750 (52%), Positives = 520/750 (69%), Gaps = 33/750 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI+D +L+WA FK  + +K+ DGTK  RL G+ KL DAN+AG R++  CTLILTEG
Sbjct: 481  VAKSGIVDNVLNWAKFKADQQMKRADGTKRSRLLGLAKLSDANNAGTRHAQDCTLILTEG 540

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGL VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKI+GLQ NK+Y
Sbjct: 541  DSAKALAIAGLGVVGRDNFGVFPLRGKLLNVREARHDQIMKNEEIQNIKKIMGLQHNKDY 600

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +N  SLRYG LMIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+VEF TPI+R    N
Sbjct: 601  TNTSSLRYGRLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPDFLVEFVTPIVRVKKGN 660

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K  F+++PEYE W E   + A  W+ KYYKGLGTS  ++ REYF  + KH   F    
Sbjct: 661  KVK-DFFTIPEYEQWLEETPD-ARKWESKYYKGLGTSEDKDAREYFSKMEKHMIPFAPTQ 718

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I++AFSKKKA++RK W+R F+PG + DH    I Y +F+NKELILFS AD  RS
Sbjct: 719  EGDRELIDLAFSKKKADERKEWLRQFKPGTFLDHRLEEIPYSEFINKELILFSMADNVRS 778

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+ DGLKPGQRK+++  FK+KL KEIKV Q +GY+SEH+AYHHGE SLA+TII +AQD
Sbjct: 779  IPSIADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAATIINLAQD 838

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNN+ LL PNGQ+GTR +GGKDHA+ RYI+T    ITR ++H  DD LL YL +D  
Sbjct: 839  YVGSNNLALLSPNGQYGTREIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKDDDV 898

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP WY+P +P+VL+NG+EGIGTGWS+ IP YNP DI+AN+RR++ +E   PM PW+RG
Sbjct: 899  PIEPEWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEEPEPMTPWWRG 958

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN----- 547
            FKG +  + K G Y V G   +I++ +  I+ELPI KWT+ +K  LE++  G        
Sbjct: 959  FKGEVRPTGK-GKYDVVGVATKINDTTVEISELPIHKWTRTFKDELEAMITGEKKDKDKD 1017

Query: 548  -----------VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTIS 595
                       VK+  +++DF+++ D+  V  E+ M  + +    ++GL++ F LTT +S
Sbjct: 1018 KDKDEDGKKDVVKNAGMVKDFKEHHDNLNVLFEVTMNPKDLEKAEEKGLVEFFGLTTKVS 1077

Query: 596  TSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFIL 655
            T+NM LFD EGKIKKYE PE+IL++F+P+RL YY++RK Y           L+N++RFI 
Sbjct: 1078 TTNMILFDFEGKIKKYETPEEILKDFYPMRLAYYQKRKDYQALELSTAYDKLNNQIRFIE 1137

Query: 656  GVVSGEIVVSNRKKADLLMELQQKGFTPMPK--KGKSAEPQVAGAXXXXXXXXXXXXXXX 713
             ++  E+VVSNRKKAD++ EL++  F P PK  K K+A+P                    
Sbjct: 1138 MIIKKELVVSNRKKADIVAELRKLNFRPFPKVAKTKTAKPDEEEEESEDEEEESGSEAVT 1197

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                       D++YLL M+I +LT E ++
Sbjct: 1198 -----------DFDYLLGMAIYSLTRERIE 1216


>A8N230_COPC7 (tr|A8N230) DNA topoisomerase 2 OS=Coprinopsis cinerea (strain
            Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
            GN=CC1G_03723 PE=3 SV=2
          Length = 1557

 Score =  795 bits (2052), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 395/750 (52%), Positives = 520/750 (69%), Gaps = 33/750 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI+D +L+WA FK  + +K+ DGTK  RL G+ KL DAN+AG R++  CTLILTEG
Sbjct: 466  VAKSGIVDNVLNWAKFKADQQMKRADGTKRSRLLGLAKLSDANNAGTRHAQDCTLILTEG 525

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGL VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKI+GLQ NK+Y
Sbjct: 526  DSAKALAIAGLGVVGRDNFGVFPLRGKLLNVREARHDQIMKNEEIQNIKKIMGLQHNKDY 585

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +N  SLRYG LMIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+VEF TPI+R    N
Sbjct: 586  TNTSSLRYGRLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPDFLVEFVTPIVRVKKGN 645

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K  F+++PEYE W E   + A  W+ KYYKGLGTS  ++ REYF  + KH   F    
Sbjct: 646  KVK-DFFTIPEYEQWLEETPD-ARKWESKYYKGLGTSEDKDAREYFSKMEKHMIPFAPTQ 703

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I++AFSKKKA++RK W+R F+PG + DH    I Y +F+NKELILFS AD  RS
Sbjct: 704  EGDRELIDLAFSKKKADERKEWLRQFKPGTFLDHRLEEIPYSEFINKELILFSMADNVRS 763

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+ DGLKPGQRK+++  FK+KL KEIKV Q +GY+SEH+AYHHGE SLA+TII +AQD
Sbjct: 764  IPSIADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAATIINLAQD 823

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNN+ LL PNGQ+GTR +GGKDHA+ RYI+T    ITR ++H  DD LL YL +D  
Sbjct: 824  YVGSNNLALLSPNGQYGTREIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKDDDV 883

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP WY+P +P+VL+NG+EGIGTGWS+ IP YNP DI+AN+RR++ +E   PM PW+RG
Sbjct: 884  PIEPEWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEEPEPMTPWWRG 943

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN----- 547
            FKG +  + K G Y V G   +I++ +  I+ELPI KWT+ +K  LE++  G        
Sbjct: 944  FKGEVRPTGK-GKYDVVGVATKINDTTVEISELPIHKWTRTFKDELEAMITGEKKDKDKD 1002

Query: 548  -----------VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTIS 595
                       VK+  +++DF+++ D+  V  E+ M  + +    ++GL++ F LTT +S
Sbjct: 1003 KDKDEDGKKDVVKNAGMVKDFKEHHDNLNVLFEVTMNPKDLEKAEEKGLVEFFGLTTKVS 1062

Query: 596  TSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFIL 655
            T+NM LFD EGKIKKYE PE+IL++F+P+RL YY++RK Y           L+N++RFI 
Sbjct: 1063 TTNMILFDFEGKIKKYETPEEILKDFYPMRLAYYQKRKDYQALELSTAYDKLNNQIRFIE 1122

Query: 656  GVVSGEIVVSNRKKADLLMELQQKGFTPMPK--KGKSAEPQVAGAXXXXXXXXXXXXXXX 713
             ++  E+VVSNRKKAD++ EL++  F P PK  K K+A+P                    
Sbjct: 1123 MIIKKELVVSNRKKADIVAELRKLNFRPFPKVAKTKTAKPDEEEEESEDEEEESGSEAVT 1182

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                       D++YLL M+I +LT E ++
Sbjct: 1183 -----------DFDYLLGMAIYSLTRERIE 1201


>R9NYN7_9BASI (tr|R9NYN7) DNA topoisomerase II OS=Pseudozyma hubeiensis SY62
            GN=PHSY_001366 PE=4 SV=1
          Length = 1523

 Score =  793 bits (2047), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 392/733 (53%), Positives = 520/733 (70%), Gaps = 23/733 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D ++S+A FKQ + LKKTDG K  R+  I KLEDAN+AGGR +  CTLILTEG
Sbjct: 492  VIKSGVVDNIVSFARFKQDQALKKTDGHKRTRITNIPKLEDANNAGGRKAKDCTLILTEG 551

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AG+  VGRD+YGVFPLRGKLLNVREAS+ QIM N EI+ IK+ILGLQ  K+Y
Sbjct: 552  DSAKSLAVAGIVEVGRDNYGVFPLRGKLLNVREASHDQIMKNAEIKAIKEILGLQHGKQY 611

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYG +MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+VEF TPI+R     
Sbjct: 612  LDVNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVRC-RKG 670

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
               LSF+++PEYE+WR+   N   GW IKYYKGLGTS  Q+ + YFR L KH+  F    
Sbjct: 671  KQDLSFFTIPEYETWRD-AHNGGKGWHIKYYKGLGTSESQDAKRYFRALEKHKLAFDVTR 729

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D   I++AF+KKKA+DRK W+R F PG Y DH   +I Y DF+NKELILFS AD  RS
Sbjct: 730  DGDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNTDKIPYADFINKELILFSMADNLRS 789

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDGLKPGQRK+++  F +K   E+KV   +G V   +AYHHGE +L+ TI+G+AQ+
Sbjct: 790  IPSVVDGLKPGQRKVMYVMFDRKSNSELKVNTLVGNVLGQAAYHHGEAALSMTIVGLAQN 849

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL+P GQFGTR LGGKD AS RYI+T L  I R LF + DD LLEYL +DG+
Sbjct: 850  FVGSNNVNLLEPRGQFGTRLLGGKDAASGRYIFTALPKIARALFPQADDALLEYLEDDGQ 909

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             +EP WYIP++P VL+NG+EGIGTGWS+ +PNYNP +I+AN+RR +  E +VPM PW+RG
Sbjct: 910  KVEPHWYIPVVPQVLMNGAEGIGTGWSTSVPNYNPHEIVANLRRRMAGEDVVPMKPWFRG 969

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G +E+    G + ++G V +IDE+++ ITELPIR WT +YK+ LE     S  V    
Sbjct: 970  FTGDVEEFG-PGRFKISGRVTQIDEKTYEITELPIRSWTSNYKESLEERIVSSDKVP-AT 1027

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+++   ++ V+  + +  +  A I ++G+   FKL+  IST+NM LFD +GKIKKY 
Sbjct: 1028 IKDYKEYHTESTVNFIVELTAKGQAEIAEKGVDTFFKLSCQISTTNMVLFDQDGKIKKYT 1087

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            + E+ILEEF+ LRL YY++RK+++++  + +   L N+ RF+  +++ ++VVSNRK+AD+
Sbjct: 1088 SAEEILEEFYLLRLSYYQKRKEHLVDQLKLMYDKLSNQARFVQMIITRQLVVSNRKRADI 1147

Query: 673  LMELQQKGFTPMPKKGK---SAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            + EL+QK F P PK+GK   +AEP+   A                          D++YL
Sbjct: 1148 VAELRQKDFRPFPKQGKASIAAEPEDDEAIDEEDISAD----------------SDFDYL 1191

Query: 730  LSMSIGTLTLESV 742
            L+M+I  LT E V
Sbjct: 1192 LNMAIYNLTKEKV 1204


>F8QG51_SERL3 (tr|F8QG51) DNA topoisomerase 2 OS=Serpula lacrymans var. lacrymans
            (strain S7.3) GN=SERLA73DRAFT_172653 PE=3 SV=1
          Length = 1484

 Score =  791 bits (2043), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 391/735 (53%), Positives = 517/735 (70%), Gaps = 21/735 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I+D +L+WA FK  + +KKTDG+K  RL G+ KL DAN+AG RN++KCTLIL
Sbjct: 474  MKKVQKSTIIDNILNWAKFKADQQIKKTDGSKRNRLTGLPKLADANNAGTRNAEKCTLIL 533

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAKALA+AGL VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKI+GLQ N
Sbjct: 534  TEGDSAKALAVAGLGVVGRDNFGVFPLRGKLLNVREAKHDQIMKNEEIQNIKKIMGLQHN 593

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K YS + SLRYG LMIM DQDHDGSHIKGLLINF+  F+PSLLK+P+F+VEF TPI+R  
Sbjct: 594  KVYSGIGSLRYGRLMIMTDQDHDGSHIKGLLINFLDHFFPSLLKIPNFLVEFVTPIVRV- 652

Query: 190  HSNG-TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
             S G  ++ F+++PEYE W E+  + A  W  KY+KGLGTS+  + R YF ++ KH   F
Sbjct: 653  -SKGKQRIDFFTIPEYEQWVEDTPD-AHKWDAKYFKGLGTSSDSDARLYFSNMAKHMIPF 710

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D D   IE+AFSKKKA++RK W+R F+ G Y DH    I+Y DF+N+ELILFS AD
Sbjct: 711  AATQDGDKELIELAFSKKKADERKEWLRQFKAGTYLDHNIDEISYSDFINRELILFSMAD 770

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIP++ DGLKPGQRK+++  FK+KL KEIKV Q +GY+SE +AYHHGE SL  TI+ 
Sbjct: 771  NIRSIPALADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEVAAYHHGEASLTMTIVN 830

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQD+VGSNN+NLL PNGQ+GTR+ GGKDHAS+RYI+TEL+P+ R +++  DD LL YL 
Sbjct: 831  LAQDYVGSNNVNLLLPNGQYGTRDQGGKDHASARYIFTELSPLARTIYNPADDPLLTYLK 890

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            ED   IEP +Y+P+IPLVL+NG+EGIGTGWS+ IP YNP DI+ N+RR++  E +VPM P
Sbjct: 891  EDNDWIEPEYYLPVIPLVLINGAEGIGTGWSTSIPCYNPEDIVNNIRRMMAGEELVPMLP 950

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG I+K   +  Y V G   +I++ +  ITELPI KWTQ+YK  LE++       
Sbjct: 951  WWRGFKGTIKKVG-DYKYDVIGVARKINDTTVEITELPIHKWTQNYKAELEAMIGEK--- 1006

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
             + +I+D++++ D+  +   I M  + +    ++GL + FKLT+ I+TSNM  F+ +GKI
Sbjct: 1007 GEGIIKDYKEHHDNVNIHFVITMSPKDLEKAEEQGLTEFFKLTSKINTSNMICFNLDGKI 1066

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            +KY+ PE+I+EEFFP RL  Y+ RK Y+    +     L N+ RF+  +V  E++V+NRK
Sbjct: 1067 QKYQTPEEIIEEFFPKRLACYQSRKDYLANELQTQFERLSNQARFVKMIVDKELIVANRK 1126

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            KAD++ EL++  F P PK  K+     A                            DY+Y
Sbjct: 1127 KADIISELRKLKFRPFPKVVKAKAAGEAEDAEEEEDETSNTST-------------DYDY 1173

Query: 729  LLSMSIGTLTLESVQ 743
            LL M+I +LT E ++
Sbjct: 1174 LLGMAIWSLTSEKIE 1188


>Q4P8R2_USTMA (tr|Q4P8R2) DNA topoisomerase 2 OS=Ustilago maydis (strain 521 / FGSC
            9021) GN=UM03501.1 PE=3 SV=1
          Length = 1518

 Score =  791 bits (2043), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/730 (53%), Positives = 514/730 (70%), Gaps = 17/730 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D ++S+A FKQ + LKKTDG K  R+  I KLEDAN+AGGR +  CTLILTEG
Sbjct: 489  VIKSGVVDNIVSFARFKQDQALKKTDGHKRTRITNIPKLEDANNAGGRKAKDCTLILTEG 548

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AG+  VGRD+YGVFPLRGKLLNVREAS+ QIM N EI+ IK+ILGLQ  K+Y
Sbjct: 549  DSAKSLAVAGIVEVGRDNYGVFPLRGKLLNVREASHDQIMKNAEIKAIKEILGLQHGKQY 608

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +  SLRYG +MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+VEF TPI+R     
Sbjct: 609  LDTNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVRC-RKG 667

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
               +SF+++PEYE+WR+   N   GW IKYYKGLGTS  Q+ + YFR L KH+  F    
Sbjct: 668  KQDISFFTIPEYETWRD-AHNGGKGWHIKYYKGLGTSESQDAKRYFRALEKHKLAFDVTR 726

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D   I++AF+KKKA+DRK W+R F PG Y DH   RI Y DF+NKELILFS AD  RS
Sbjct: 727  DGDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNTDRIPYADFINKELILFSMADNLRS 786

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS +DGLKPGQRK+++  F +K   E+KV   +G V   +AYHHGE +L+ TI+G+AQ+
Sbjct: 787  IPSAIDGLKPGQRKVMYVMFDRKSNSELKVNTLVGNVLGQAAYHHGEAALSMTIVGLAQN 846

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL+P GQFGTR LGGKD AS RYI+T L  I R LF   DD LL+YL +DG+
Sbjct: 847  FVGSNNVNLLEPRGQFGTRLLGGKDAASGRYIFTALPKIARALFPATDDALLDYLEDDGQ 906

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             +EP WYIP++P VL+NG+EGIGTGWS+ +PNYNP +I+AN+RR +  E +VPM PWYRG
Sbjct: 907  KVEPHWYIPVVPQVLLNGAEGIGTGWSTSVPNYNPHEIVANLRRRMAGEDVVPMKPWYRG 966

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G +E+    G + ++G V +IDE+++ ITELPIR WT +YK+ LE     S  +    
Sbjct: 967  FNGDVEEFG-PGRFKISGRVTQIDEKTYEITELPIRTWTSNYKELLEERIVSSDKIP-AT 1024

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+++   ++ V+  + +  +  A I  +G+   FKL+  IST+NM LFD +GKIKKY 
Sbjct: 1025 IKDYKEYHTESTVNFIVELTAKGQAEIADKGVEAFFKLSCQISTTNMVLFDQDGKIKKYT 1084

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            + E+ILEEF+ LRL YY++RK+Y+++  + +   L N+ RF+  ++S ++VVSNRK+AD+
Sbjct: 1085 SAEEILEEFYLLRLSYYQKRKEYLVDQLKLMYDKLSNQARFVQMIISRQLVVSNRKRADI 1144

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL+QK F P PK+GK++   +A                            D++YLL+M
Sbjct: 1145 VAELRQKDFRPFPKQGKAS---IAAEPEDDEAIDDEDISAD----------SDFDYLLNM 1191

Query: 733  SIGTLTLESV 742
            +I  LT E V
Sbjct: 1192 AIYNLTKEKV 1201


>K9IC41_AGABB (tr|K9IC41) DNA topoisomerase 2 OS=Agaricus bisporus var. bisporus
            (strain H97 / ATCC MYA-4626 / FGSC 10389)
            GN=AGABI2DRAFT_197775 PE=3 SV=1
          Length = 1551

 Score =  791 bits (2042), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 391/730 (53%), Positives = 512/730 (70%), Gaps = 17/730 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + I+D +L WA  K  + +KKTDG+K  RL G+ KL DAN+AG R +  CTLILTEG
Sbjct: 477  VLKTAIVDNVLHWAKAKADQQIKKTDGSKRNRLVGLTKLSDANNAGTRLAKDCTLILTEG 536

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGL VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKILGLQ NK+Y
Sbjct: 537  DSAKALAVAGLGVVGRDYFGVFPLRGKLLNVREAKHDQIMKNEEIQNIKKILGLQHNKDY 596

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            S+V SLRYG LMIMADQDHDGSHIKGLLINF   F+PSLLK+P F+VEF TPI+R     
Sbjct: 597  SDVSSLRYGRLMIMADQDHDGSHIKGLLINFFDHFYPSLLKLPEFLVEFVTPIVRIIKGK 656

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              +  F+++PEYE W      +A  W+ KYYKGLGTS   + R+YF  + KH   F    
Sbjct: 657  HRR-DFFTLPEYEKWLLE-APDAHKWESKYYKGLGTSNDADARDYFSHMAKHMIPFAPTQ 714

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I++AFSKKKA+DRK W+R F PG + DH    I Y +F+NKELI FS AD  RS
Sbjct: 715  NGDRDLIDLAFSKKKADDRKEWLRQFRPGTFLDHNLEEIPYSEFINKELICFSMADNIRS 774

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP V DGLKPGQRK+++  FK+KL KEIKV Q +GY+SEH+AYHHGE SLA TII +AQD
Sbjct: 775  IPCVADGLKPGQRKVIWSCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAQTIINLAQD 834

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL PNGQ+GTR+ GGKDHAS RYI+TE   +TR ++H +DD LL+   ED +
Sbjct: 835  FVGSNNVNLLSPNGQYGTRDQGGKDHASPRYIFTEPKAMTRVVYHPDDDPLLKGQREDNQ 894

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP +Y+P+IPLVL NG+EGIGTGWS+ IP +NP  I+ N+RRL+N E  V M PW+RG
Sbjct: 895  WIEPEFYLPVIPLVLCNGAEGIGTGWSTNIPCFNPAVIVENIRRLMNGEEQVAMKPWWRG 954

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG I  +AK   Y V+G + ++D+ +  ITELPI +WTQ+YK  LE++  G  N K+ +
Sbjct: 955  FKGEIIATAKHK-YDVHGVIHKLDDTTVEITELPIHRWTQNYKADLEAMIAGGEN-KEGV 1012

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D++++ D+A V   I M  + +    ++GL + FKLT+ ++TSNM  FD EGKIK+YE
Sbjct: 1013 IKDYKEHHDNANVHFVISMSAKDLEKAEEQGLREFFKLTSKLTTSNMICFDFEGKIKRYE 1072

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PEQI+E+F+P+RL YY++RK Y+    +  L  L+N+ RF+  +V  ++VVS R+KAD+
Sbjct: 1073 SPEQIIEDFYPVRLAYYQKRKDYLAGELQDSLDKLNNQARFVKMIVDKKLVVSGRRKADI 1132

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L++  F P+PK  K+   Q                              D++Y+L M
Sbjct: 1133 VADLRKLDFKPIPKVSKAKSTQQEENDEDEEQEEAGAD-------------SDFDYMLGM 1179

Query: 733  SIGTLTLESV 742
            +I +LT E +
Sbjct: 1180 AIWSLTKEKI 1189


>F0WKX4_9STRA (tr|F0WKX4) DNA topoisomerase 2 OS=Albugo laibachii Nc14
            GN=AlNc14C138G7164 PE=3 SV=1
          Length = 1499

 Score =  790 bits (2041), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 397/743 (53%), Positives = 518/743 (69%), Gaps = 34/743 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKK--TDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            +  SGI++ ++S+A FKQ+ +L++    G    +L GI KL+DAN AG     KCTLILT
Sbjct: 440  IEKSGIVERVVSFAKFKQTAELQRKGAKGGNRSKLTGITKLDDANYAGTAEGRKCTLILT 499

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+L + GLSVVGRD+YGVFPL+GKLLNVREAS+ QI+ NEEIQN+ KILGL+  +
Sbjct: 500  EGDSAKSLTIGGLSVVGRDYYGVFPLKGKLLNVREASHSQILKNEEIQNVVKILGLKYGQ 559

Query: 131  EYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
             Y + KSLRYGHLMIMADQDHDGSHIKGL+INFIH FWPSLL+V  FM EF TPI++   
Sbjct: 560  VYESTKSLRYGHLMIMADQDHDGSHIKGLVINFIHHFWPSLLQVEGFMHEFITPIVKCAK 619

Query: 191  SNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             +  ++ FY+MPEYE+WR    NN  GW+IKYYKGLGTST +E +EYF DL  H+ DF +
Sbjct: 620  GSKKEV-FYTMPEYEAWRL-ATNNGQGWRIKYYKGLGTSTTEEAKEYFSDLATHQIDFSY 677

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
            + + DG +I+MAFSKK+ E+RK W+R + PG + D+  + + Y +FVNKELILFSRAD  
Sbjct: 678  KGEEDGDSIDMAFSKKRVEERKNWLRGYTPGTHVDYNIADMPYSEFVNKELILFSRADNM 737

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIP +VDG KP QRK+L+C FK+ L  EIKV Q  GYVSEHS+YHHGE SL  TII MA
Sbjct: 738  RSIPCLVDGFKPSQRKVLYCCFKRNLRVEIKVAQLAGYVSEHSSYHHGEASLHGTIINMA 797

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDF+GSNN NLL PNGQFGTR LGGKD AS RYI+T+L  I    F  ND+ LL YL+ED
Sbjct: 798  QDFIGSNNSNLLSPNGQFGTRILGGKDAASPRYIFTKLEAIAYKFFDPNDNSLLNYLDED 857

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR-RLLNDETMVPMDPW 489
            G+ IEP WY+P+IP+VLVNGSEGIGTGWSS+IPNYNP D+I N+R R+  +    P+ PW
Sbjct: 858  GQLIEPEWYVPVIPMVLVNGSEGIGTGWSSFIPNYNPLDLIENLRARIKGEAPTKPLVPW 917

Query: 490  YRGFKGIIEKSA--KEG---GYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDG 544
            YRGF G IE+ +  ++G    ++V G     D+ +  ITELP++ WT  YKQFLES+   
Sbjct: 918  YRGFTGSIEERSGTRDGDSQAFVVRGIFHVEDDSTLVITELPVKTWTHTYKQFLESL--- 974

Query: 545  SPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLF 602
               +++  I+DF++N  D+ V   I M  EK+  I+    G+++KFKL ++IS +NMHLF
Sbjct: 975  ---MENDTIKDFKENHTDSKVLFTISMTPEKMQEIVLSPGGIMRKFKLESSISAANMHLF 1031

Query: 603  DAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEI 662
            DA+G+I+KY++P +I+  F+ +RL YY +RK  +L+     + +L NKV+FIL V+ G++
Sbjct: 1032 DADGRIQKYDSPHEIISAFYDIRLAYYGKRKAAMLQKLTDQIEMLANKVKFILAVIQGDL 1091

Query: 663  VVSNRKKADLLMELQQKGFT---PMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXX 719
            +VSNRKK +LL EL + G+    P   KGK+++                           
Sbjct: 1092 IVSNRKKVELLHELVEMGYDKLYPNNSKGKNSDEDEEKDDQEGDEEEGDLTKG------- 1144

Query: 720  XXKRGDYEYLLSMSIGTLTLESV 742
                  Y YLLSM I +LT E V
Sbjct: 1145 ------YNYLLSMKIWSLTKERV 1161


>K5Y6A9_AGABU (tr|K5Y6A9) DNA topoisomerase 2 OS=Agaricus bisporus var. burnettii
            (strain JB137-S8 / ATCC MYA-4627 / FGSC 10392)
            GN=AGABI1DRAFT_117173 PE=3 SV=1
          Length = 1549

 Score =  789 bits (2038), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 391/730 (53%), Positives = 511/730 (70%), Gaps = 17/730 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + I+D +L WA  K  + +KKTDG+K  RL G+ KL DAN+AG R +  CTLILTEG
Sbjct: 475  VLKTAIVDNVLHWAKAKADQQIKKTDGSKRNRLVGLTKLSDANNAGTRLAKDCTLILTEG 534

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGL VVGRD++GVFPLRGKLLNVREA + QIM NEEIQNIKKILGLQ NK+Y
Sbjct: 535  DSAKALAVAGLGVVGRDYFGVFPLRGKLLNVREAKHDQIMKNEEIQNIKKILGLQHNKDY 594

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            S+V SLRYG LMIMADQDHDGSHIKGLLINF   F+PSLLK+P F+VEF TPI+R     
Sbjct: 595  SDVSSLRYGRLMIMADQDHDGSHIKGLLINFFDHFYPSLLKLPEFLVEFVTPIVRIIKGK 654

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              +  F+++PEYE W      +A  W+ KYYKGLGTS   + R+YF  + KH   F    
Sbjct: 655  HRR-DFFTLPEYEKWLLE-APDAHKWESKYYKGLGTSNDADARDYFSHMAKHMIPFAPTQ 712

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I++AFSKKKA+DRK W+R F PG + DH    I Y +F+NKELI FS AD  RS
Sbjct: 713  HGDRDLIDLAFSKKKADDRKEWLRQFRPGTFLDHNLEEIPYSEFINKELICFSMADNIRS 772

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP V DGLKPGQRK+++  FK+KL KEIKV Q +GY+SEH+AYHHGE SLA TII +AQD
Sbjct: 773  IPCVADGLKPGQRKVIWSCFKRKLKKEIKVAQLVGYISEHAAYHHGEASLAQTIINLAQD 832

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL PNGQ+GTR+ GGKDHAS RYI+TE   +TR ++H +DD LL+   ED +
Sbjct: 833  FVGSNNVNLLSPNGQYGTRDQGGKDHASPRYIFTEPKAMTRVVYHPDDDPLLKGQREDNQ 892

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP +Y+P+IPLVL NG+EGIGTGWS+ IP +NP  I+ N+RRL+N E  V M PW+RG
Sbjct: 893  WIEPEFYLPVIPLVLCNGAEGIGTGWSTNIPCFNPAVIVENIRRLMNGEEQVAMKPWWRG 952

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            FKG I  +AK   Y V+G + ++D+ +  ITELPI +WTQ+YK  LE++  G  N K+ +
Sbjct: 953  FKGEIIATAKHK-YDVHGVIHKLDDTTVEITELPIHRWTQNYKADLEAMIAGGEN-KEGV 1010

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D++++ D+A V   I M  + +    ++GL + FKLT+ ++TSNM  FD EGKIK+YE
Sbjct: 1011 IKDYKEHHDNANVHFVISMSAKDLEKAEEQGLREFFKLTSKLTTSNMICFDFEGKIKRYE 1070

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PEQI+E+F+P+RL YY++RK Y+    +  L  L+N+ RF+  +V  ++VVS R+KAD+
Sbjct: 1071 SPEQIIEDFYPVRLAYYQKRKDYLAGELQDSLDKLNNQARFVKMIVDKKLVVSGRRKADI 1130

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L++  F P+PK  K+   Q                              D++Y+L M
Sbjct: 1131 VADLRKLDFKPIPKISKAKSTQQEENDEDEEQEEAGAD-------------SDFDYMLGM 1177

Query: 733  SIGTLTLESV 742
            +I +LT E +
Sbjct: 1178 AIWSLTKEKI 1187


>J3PRY3_PUCT1 (tr|J3PRY3) DNA topoisomerase 2 OS=Puccinia triticina (isolate 1-1 /
            race 1 (BBBD)) GN=PTTG_01899 PE=3 SV=1
          Length = 1579

 Score =  788 bits (2036), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/733 (53%), Positives = 509/733 (69%), Gaps = 10/733 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  SG++D+++ +A FK+   LKKTDG+K  R+ GIVKLEDAN+AG + +  CTLIL
Sbjct: 411  MKKVMKSGVIDSVMDFAKFKEEAALKKTDGSKRSRITGIVKLEDANNAGTKKAADCTLIL 470

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA+AGLSV+GRD+YGVFPLRGKLLNVREAS  Q++ N EIQ+IK+I+GLQQ 
Sbjct: 471  TEGDSAKSLAVAGLSVIGRDNYGVFPLRGKLLNVREASGAQLLSNAEIQHIKQIMGLQQG 530

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y++  SLRYG LMIM DQDHDGSHIKGL+INF+  F+PSLL++P F+VEF TPI++  
Sbjct: 531  KKYASRDSLRYGSLMIMTDQDHDGSHIKGLIINFLDYFFPSLLEIPGFLVEFITPIVKVT 590

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
                 ++SF++MPE+E W+E   +   GW  KYYKGLGTS  ++ ++YF  +  HR  F 
Sbjct: 591  KKK-EEISFFTMPEFEKWKEE-NDGGRGWTSKYYKGLGTSDAKDAKKYFSRMSSHRIKFA 648

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
               + D S I+MAF+KKKA+DRK W+R FEPG + D   S+I Y +F+NKELILFS AD 
Sbjct: 649  PTQENDRSLIDMAFNKKKADDRKEWLRGFEPGTHLDQNVSQITYSEFINKELILFSMADN 708

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPS+VDG KPGQRK+LF  FK+KL  EIKV Q  GY SEHSAYHHGE SL  TI+G+
Sbjct: 709  IRSIPSMVDGFKPGQRKVLFACFKRKLKAEIKVAQLGGYCSEHSAYHHGEASLTQTIVGL 768

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQ+FVGSNNIN+L PNGQFGTR  GGKD AS+RYI+T +  ITR +F  +DD +L YL +
Sbjct: 769  AQNFVGSNNINVLSPNGQFGTRASGGKDAASARYIFTNVEKITRVIFPPSDDNILTYLTD 828

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            DG  IEP WYIP++P+VLVNGS GIGTGWSS IPNYNP DI+ N+RR L DE M PM PW
Sbjct: 829  DGTQIEPEWYIPVLPMVLVNGSSGIGTGWSSDIPNYNPVDIVNNLRRRLADEPMEPMHPW 888

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            +RGF G I   A  G Y V G  ++ DE +  ITELPIR W Q YK+ +E+  + +  + 
Sbjct: 889  FRGFTGQILPEA-PGKYKVLGEWDQPDEDTLEITELPIRVWNQSYKEQIEAWINSTEKIP 947

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
              L++D+R+   +  V   I +  +    I +EG  K FKL+ ++S +NM  FD  GKIK
Sbjct: 948  -ALVKDYREYHTETTVHFIISLTEKGKEAIKKEGAEKVFKLSGSLSINNMVCFDPLGKIK 1006

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KY  PEQIL++FF +RL  Y++RK+Y++ +       L N+ RF+L ++  +++V+NRKK
Sbjct: 1007 KYATPEQILDDFFDVRLACYQKRKEYLVNDLTLTYERLSNQARFVLMIIEKKLIVNNRKK 1066

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            AD++ EL++  F P P K     P+V  A                         GD++YL
Sbjct: 1067 ADIVAELRKLEFRPFPMK-----PKVKTAGDPDQADEEGAEEEVADVGAAGTA-GDFDYL 1120

Query: 730  LSMSIGTLTLESV 742
            L M+I  LT E V
Sbjct: 1121 LGMAISRLTAEQV 1133


>G7DZ82_MIXOS (tr|G7DZ82) DNA topoisomerase 2 OS=Mixia osmundae (strain CBS 9802 /
            IAM 14324 / JCM 22182 / KY 12970) GN=Mo02550 PE=3 SV=1
          Length = 1497

 Score =  788 bits (2034), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 385/729 (52%), Positives = 506/729 (69%), Gaps = 20/729 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  SG++D +L+WA FK+ + LKKTDG K  R+ GI KLEDAN AG +N   CTLILTEG
Sbjct: 493  ITKSGVVDNVLNWAKFKEEQQLKKTDGHKRSRITGISKLEDANQAGTKNGRNCTLILTEG 552

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL VVGRD +GVFPLRGKLLNVRE+  K + DN EI  +K+I+GLQ  K Y
Sbjct: 553  DSAKALAVSGLEVVGRDTFGVFPLRGKLLNVRESQGKTLTDNIEINAVKQIMGLQHGKTY 612

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLL++P F+VEF TPI++   + 
Sbjct: 613  ESVDSLRYGHLMIMTDQDHDGSHIKGLIINFLDYFFPSLLRIPGFLVEFITPIVKISRAR 672

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              + +F++MPEYE+W+    N+  GW IKYYKGLGTST  + R+YF D+  HR  F   D
Sbjct: 673  QER-AFFTMPEYEAWKAE-NNDGRGWDIKYYKGLGTSTAADARKYFGDMDSHRLGFRVSD 730

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D S I+MAF+KKKA+DRK W+ +F PG + DH   +I   DFVN+ELIL+S AD  RS
Sbjct: 731  DADRSLIDMAFNKKKADDRKDWLASFIPGTFLDHSIKQIPISDFVNRELILYSMADNIRS 790

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDG KPGQRK+LF  FK+ L KEIKV Q  GYVSE SAYHHGE SL  TI+G+AQ+
Sbjct: 791  IPSLVDGFKPGQRKVLFGCFKRNLKKEIKVAQLGGYVSEQSAYHHGEASLYGTIVGLAQN 850

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL PNGQFGTR  GGKD AS+RYI+T +  ITR +FH  DD LL YL++DG+
Sbjct: 851  FVGSNNINLLDPNGQFGTRLQGGKDAASARYIFTNVAQITRTIFHPADDNLLTYLSDDGQ 910

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR-RLLNDETMVPMDPWYR 491
            SIEPSWY+P+IP+VLVNGS+GIGTGWSS IP YNP DIIAN+R +L + +  +P+ PWYR
Sbjct: 911  SIEPSWYMPVIPMVLVNGSDGIGTGWSSTIPTYNPADIIANLRAKLADKDERIPLLPWYR 970

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            G+KG I +   +  +   G   + DE +  ITELP+R WTQ YK+ LE+   G+      
Sbjct: 971  GYKGEIVRLGADK-FKCLGVWSQPDEDTLEITELPVRVWTQTYKELLEAWIQGTEKAP-A 1028

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            LI+D+++   +  V  ++++  +    I ++G+ K FKL++ +ST NM  FD +GKI+KY
Sbjct: 1029 LIKDYKEYHANTTVHFKLQLTAKGKEAIAKDGIEKTFKLSSAVSTGNMVCFDLQGKIQKY 1088

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
              PE IL+ F+  RL +Y++RK+Y+ +  E     L N+ RFIL +++ E+V++NRK+A+
Sbjct: 1089 STPEAILDAFYDFRLTFYQKRKEYLTKELELAHQRLSNQARFILAIINKELVIANRKRAE 1148

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            L+ EL+ K + P P+ GK     V                             DYEYL  
Sbjct: 1149 LVAELRAKSYQPFPR-GKRVAVDV--------------DEDDAANDALDLSAADYEYLFG 1193

Query: 732  MSIGTLTLE 740
            +++ TLT E
Sbjct: 1194 LALSTLTAE 1202


>F4R8C9_MELLP (tr|F4R8C9) DNA topoisomerase 2 OS=Melampsora larici-populina (strain
            98AG31 / pathotype 3-4-7) GN=MELLADRAFT_46846 PE=3 SV=1
          Length = 1259

 Score =  788 bits (2034), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/730 (53%), Positives = 517/730 (70%), Gaps = 12/730 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D+++ +A  K+   LKKTDG+K  R+ GIVKLEDAN+AG + + +CTLILTEG
Sbjct: 498  VMKSGVIDSVVDFAKLKEEVALKKTDGSKRSRITGIVKLEDANNAGTKKAAECTLILTEG 557

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AGL+V+GRD+YGVFPLRGKLLNVREAS  Q++ N EIQ+IKKI+GLQQ K+Y
Sbjct: 558  DSAKSLAVAGLTVIGRDNYGVFPLRGKLLNVREASGTQLLANAEIQHIKKIMGLQQGKKY 617

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ +SLRYG LMIM DQDHDGSHIKGL+INF+  F+PSLL++P F+VEF TPI++     
Sbjct: 618  TSRESLRYGSLMIMTDQDHDGSHIKGLIINFLDYFFPSLLEIPGFLVEFITPIVKVTRKK 677

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              +LSF++MPE+E W+E   N    WK KYYKGLGTS  ++ ++YF  +  HR  F    
Sbjct: 678  -QELSFFTMPEFERWKEE-NNGGREWKSKYYKGLGTSDAKDAKKYFSKMSSHRIKFAPTQ 735

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I+MAF+KKKA++RK W+R FEPG + DH  S+I+Y +F+NKELILFS AD  RS
Sbjct: 736  PTDRDLIDMAFNKKKADNRKEWLRGFEPGTHLDHNVSQISYTEFINKELILFSMADNIRS 795

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDG KPGQRK+LF  FK+KL  EIKV Q  GY +EHSAYHHGEQSL  TI+ +AQ+
Sbjct: 796  IPSMVDGFKPGQRKVLFACFKRKLKAEIKVAQLGGYCAEHSAYHHGEQSLTQTIVALAQN 855

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNIN+L PNGQFGTR  GGKD AS+RYI+T +  ITR +F   DD +L YLN+DG 
Sbjct: 856  FVGSNNINVLSPNGQFGTRANGGKDAASARYIFTNIEKITRAIFPPQDDHVLNYLNDDGA 915

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP WY+P++P+VLVNGS GIGTGWSS IPNYNP DI+ N+RR L+DE + P+ PW+RG
Sbjct: 916  QIEPEWYVPVLPMVLVNGSSGIGTGWSSDIPNYNPMDIVENLRRKLSDEPLEPIYPWFRG 975

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G I   A  G + V G   + DE +  ITELPIR W   YK+ LE+    +  V   L
Sbjct: 976  FTGHITPEAP-GKFKVTGEWNQPDEDTVEITELPIRVWNLTYKELLEAWITSTDKVP-AL 1033

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            ++D+R+   +  V   I++  +    I ++GL K FKLT  +ST+NM  FD+ GKIKKY 
Sbjct: 1034 VKDYREYHTETTVHFIIQLTDKGKEAIKKDGLEKVFKLTGNVSTTNMVCFDSFGKIKKYS 1093

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             PE+ILE+F+ +RL+YY++RK++++++       L N+ RF+L ++  +++++NRKKA++
Sbjct: 1094 TPEEILEDFYDIRLEYYQKRKEFLVQDLTTTYERLSNQARFVLMIIEKKLIINNRKKAEV 1153

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            +++L++  F P P+K K   P+ AG                          GDY+YLLSM
Sbjct: 1154 VIDLRKLDFRPFPRKPK---PKTAGDPDQVGEDDQEEEEHDEVESA-----GDYDYLLSM 1205

Query: 733  SIGTLTLESV 742
            +I  LT E V
Sbjct: 1206 AISRLTAEQV 1215


>R4X883_9ASCO (tr|R4X883) DNA topoisomerase 2 OS=Taphrina deformans PYCC 5710
            GN=TAPDE_001558 PE=4 SV=1
          Length = 1525

 Score =  787 bits (2033), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 382/739 (51%), Positives = 516/739 (69%), Gaps = 23/739 (3%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  SG+LD +   ++ +  K +KKTDG K  R+ G+ KLEDAN AG R +++CTLIL
Sbjct: 464  MKKVLKSGVLDDITRQSEMRADKAMKKTDGAKRTRITGMAKLEDANKAGTREAERCTLIL 523

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK LA++G+SVVGRDH+GVFPLRGKLLNVR+A+  Q+  N EIQNIK+ILGL+  
Sbjct: 524  TEGDSAKTLAISGMSVVGRDHFGVFPLRGKLLNVRDAAANQVSANTEIQNIKQILGLKHG 583

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
             +Y + K LRYGHLMIM DQDHDGSHIKGL+IN++  F+PSLL +P F++EF TPI+R  
Sbjct: 584  VKYKDAKELRYGHLMIMTDQDHDGSHIKGLIINYLECFYPSLLSIPGFLIEFITPIVRCT 643

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
                  +SF+++PEYE+W+E++      WKIKY+KGLGTS   + ++YF DL KH K+F 
Sbjct: 644  KGKEV-VSFFTIPEYEAWKEDV-QPGKEWKIKYFKGLGTSDTADAKKYFSDLDKHLKEFH 701

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
               D D   I +AFSK +A+DRK W+R F PG Y DH  ++I +K+F+N ELILFS AD 
Sbjct: 702  TLQDGDQDLISLAFSKHRADDRKEWLRKFVPGTYMDHSMTKIPFKNFINDELILFSMADN 761

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIP+V+DG KPGQRKILF  FK+KL  EIKV Q +GYV EH+AYHHGEQSL+ TI+G+
Sbjct: 762  IRSIPNVMDGFKPGQRKILFACFKRKLKAEIKVAQLVGYVGEHTAYHHGEQSLSQTIVGL 821

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQ FVGSNNIN+L PNGQFGTR+ GGKD AS+RYI+T++  I R +F E D  LL YLN+
Sbjct: 822  AQSFVGSNNINILMPNGQFGTRHSGGKDAASARYIFTDIAKIARKIFVEPDSPLLNYLND 881

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            DG  +EP W+ PI+P++LVNG++GIGTGWS+ IPN+NP D++ N+R+L++ E + PM+PW
Sbjct: 882  DGLMVEPQWFAPILPMILVNGAQGIGTGWSTSIPNFNPADLVRNIRKLMDGEEIKPMEPW 941

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI---TDGSP 546
            YRGF+G+IE+  K+ GY   G V EID+ +  ITELP+  WT D K+FLE     TD SP
Sbjct: 942  YRGFQGLIEEDPKQKGYRAQGIVHEIDDTTVEITELPLGFWTLDMKEFLEQAIAGTDKSP 1001

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
                P ++D+  N  ++ +   I +  + +   +  GLL+KFKLT  IS  N+  FD +G
Sbjct: 1002 ----PWVKDYADNSTESRIHFTITLTDKSMKDALHTGLLEKFKLTKNISMQNLVAFDPDG 1057

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I+KY + E+IL+EF+ +RL +Y+RRK ++  + E+    L N+ RF+  +++ E+ VSN
Sbjct: 1058 RIRKYNSAEEILKEFYHIRLQFYQRRKDWMAADLEKQYDRLSNQARFVQMIINKELSVSN 1117

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD- 725
            +K+A L+ EL+   FTP P K K+A  QVAG                        K  D 
Sbjct: 1118 KKRAALVDELKALKFTPFPTK-KTA--QVAG---------ETEESLEDDAEENAEKHSDH 1165

Query: 726  -YEYLLSMSIGTLTLESVQ 743
             Y+YLL M+I +LT E V+
Sbjct: 1166 GYDYLLGMAIWSLTRERVE 1184


>M9LUR2_9BASI (tr|M9LUR2) Uncharacterized protein OS=Pseudozyma antarctica T-34
            GN=PANT_8d00062 PE=4 SV=1
          Length = 2299

 Score =  786 bits (2029), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 386/730 (52%), Positives = 520/730 (71%), Gaps = 17/730 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D ++S+A +KQ + LKKTDG K  R+  I KLEDAN+AGGR +  CTLILTEG
Sbjct: 1448 VIKSGVVDNIVSFARYKQDQALKKTDGHKRTRITNIPKLEDANNAGGRKARDCTLILTEG 1507

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL  VGRD+YGVFPLRGKLLNVREAS+ QIM N EI+ IK+ILGLQ  K+Y
Sbjct: 1508 DSAKALAVSGLVEVGRDNYGVFPLRGKLLNVREASHDQIMKNSEIKAIKEILGLQHGKQY 1567

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYG +MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+VEF TPI++     
Sbjct: 1568 LDVNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVKCTKGK 1627

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              +LSF+++PEY +W+E   NN  GW+IKY+KGLGTS  Q+ ++YFR + KH   F    
Sbjct: 1628 -QELSFFTIPEYMTWKEQ-HNNGKGWRIKYFKGLGTSDSQDAKKYFRAMDKHMLPFDVTK 1685

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D   I++AF+KKKA+DRK W+R F PG Y DH    I Y DF+NKELILFS AD  RS
Sbjct: 1686 DGDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNIDTIPYADFINKELILFSMADNLRS 1745

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS VDGLKPGQRK++F +F ++   EIKV Q +G++   +AYHHG+ SL  TI+G+AQ+
Sbjct: 1746 IPSAVDGLKPGQRKVIFGTFNRRGDGEIKVAQLVGHIIGTTAYHHGDASLTMTIVGLAQN 1805

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL+P GQFGTR LGGKD AS+RYI+T L  ITR LF + DD LL +L++DG+
Sbjct: 1806 FVGSNNVNLLEPRGQFGTRLLGGKDAASARYIFTALPKITRALFPQADDALLNFLDDDGQ 1865

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+P++P VL+NG+EGIGTGWS+ +PNYNP +I+AN+RR +  E +VPM PWYRG
Sbjct: 1866 SIEPEWYMPVVPQVLMNGAEGIGTGWSTSVPNYNPHEIVANIRRRMAGEEVVPMKPWYRG 1925

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G I++ A  G + V+G V +ID++++ ITELPIR WT  YK+ LE     +  V    
Sbjct: 1926 FTGDIDEVAP-GRFKVSGRVTQIDDKTYEITELPIRTWTSTYKEGLEERIVSTEKVP-AT 1983

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+++   ++ V   + +  +  A I  +G+   FK++  IST+NM LFD +GKIKKY 
Sbjct: 1984 IKDYKEYHTESTVHFIVELTAKGQAEIADKGVEAFFKMSAQISTTNMVLFDQDGKIKKYS 2043

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             PE+ILE+F+ LRL YY++RK+++++  + +   L N+ RF+  +++ ++VVSNRK+AD+
Sbjct: 2044 TPEEILEDFYLLRLSYYQKRKEHLVDQLKLMYDRLSNQARFVQMIINRQLVVSNRKRADI 2103

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L++  F P PK+GK+A   VA                            DY+YLL+M
Sbjct: 2104 VADLRENDFRPFPKQGKAA---VAAEIEDAEPVDESDISAD----------SDYDYLLNM 2150

Query: 733  SIGTLTLESV 742
            +I  LT E V
Sbjct: 2151 AIYNLTKEKV 2160


>F0VN61_NEOCL (tr|F0VN61) DNA topoisomerase 2 OS=Neospora caninum (strain
            Liverpool) GN=NCLIV_055820 PE=3 SV=1
          Length = 1641

 Score =  783 bits (2021), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/743 (52%), Positives = 515/743 (69%), Gaps = 19/743 (2%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKK------TDGTKTQRLRGIVKLEDANDAGGRNSDKC 65
            AV  S I++ ++ WA  KQ  +L+K      T G   +RL GI KLEDANDAGGR+S +C
Sbjct: 466  AVVKSSIVENVVLWAQTKQQVELRKQMKVGKTKGR--ERLSGIPKLEDANDAGGRHSQEC 523

Query: 66   TLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILG 125
            TLILTEGDSAK   +AGLSVVGRD YGVFPLRGKLLNVR+AS KQ+ +N+EIQNI KI+G
Sbjct: 524  TLILTEGDSAKTSCLAGLSVVGRDRYGVFPLRGKLLNVRDASFKQLTENKEIQNILKIVG 583

Query: 126  LQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPI 185
            LQ N    + + LRYG +MIM DQDHDGSHIKGLLIN +H +WP LLK   F+  F TPI
Sbjct: 584  LQVNDRTEDARGLRYGSVMIMTDQDHDGSHIKGLLINMMHHYWPQLLKCRGFLKAFLTPI 643

Query: 186  IRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHR 245
            ++   +N  K +FY++PEYE W+ +   N TGW+IKYYKGLGTST +E +EYF DL KH+
Sbjct: 644  VKVSKNNVEK-AFYTIPEYEQWKRSC--NTTGWRIKYYKGLGTSTDREFKEYFNDLSKHQ 700

Query: 246  KDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFS 305
             DFVW   +DG  I+MAF+K++AEDRK W+++++ G + DH AS ++Y DFVNKELILFS
Sbjct: 701  IDFVWSGQHDGELIDMAFNKRRAEDRKRWLQSYQEGTFVDHNASSLSYADFVNKELILFS 760

Query: 306  RADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLAST 365
            R D +RSIP +VDG KPGQRK+LF   KK +  EIKV Q  GYV+E SAYHHGE SL  T
Sbjct: 761  RYDTERSIPQLVDGWKPGQRKVLFACIKKNMKHEIKVAQLAGYVAEVSAYHHGEASLQQT 820

Query: 366  IIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLE 425
            I+ MAQ FVGSNN+N L+P GQFG+R  GGKD +++RYI+T L   TR +FHE DD +LE
Sbjct: 821  IVTMAQRFVGSNNLNFLEPVGQFGSRKEGGKDASAARYIFTRLAFYTRLVFHEADDPILE 880

Query: 426  YLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVP 485
            Y  E+G+ IEP  Y+P+IP VL+NGSEGIGTGWSS++PNYNPRD+I N+RR ++ E M  
Sbjct: 881  YEYEEGQRIEPKMYVPVIPTVLINGSEGIGTGWSSFVPNYNPRDVIENLRRYIDGEEMQR 940

Query: 486  MDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            M PWYRGF+G IE+++   G+  +G VE+  E +F ITELPI+KWTQDYK++LE   +  
Sbjct: 941  MTPWYRGFRGKIEENSAGTGFETSGLVEKCGEGAFEITELPIKKWTQDYKEWLE---ENL 997

Query: 546  PNV--KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFD 603
            P    +D LI D+R       +   +++  E++    +EGL K FKL T++ST+N+ LFD
Sbjct: 998  PTAEKRDTLIADYRDCSSHEEIHFTVKVSEERLERPEREGLEKYFKLKTSLSTTNLTLFD 1057

Query: 604  AEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIV 663
              G++++Y N  +I++EF P+RLD+Y RRK Y L   E+   +L N++RFIL VV+G+++
Sbjct: 1058 PHGRVQRYANELEIIKEFAPIRLDFYHRRKAYCLAMLEKSRRILSNRLRFILAVVNGQLI 1117

Query: 664  VSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXX---XXXXXXXXXXXXXXXXXXXX 720
            ++N++K  L+ EL  +G+ PM +   +A   +  A                         
Sbjct: 1118 INNKRKKVLVEELFSQGYDPMKEIEDAANAGIRAALKRDIAVDDEALAEGGEEEEEIVAG 1177

Query: 721  XKRGDYEYLLSMSIGTLTLESVQ 743
                 Y+YLL M + +LTLE V+
Sbjct: 1178 CTAKHYDYLLGMPMWSLTLEKVE 1200


>F4NTP0_BATDJ (tr|F4NTP0) DNA topoisomerase 2 (Fragment) OS=Batrachochytrium
            dendrobatidis (strain JAM81 / FGSC 10211)
            GN=BATDEDRAFT_18312 PE=3 SV=1
          Length = 1218

 Score =  780 bits (2013), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 385/738 (52%), Positives = 512/738 (69%), Gaps = 14/738 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGT-KTQRLRGIVKLEDANDAGGRNSDKCTLI 68
            M  V  SGI+DT++ +A FKQ + LKKTDG+ K  R+ GI KL+DAN+AG +N  KCTLI
Sbjct: 454  MKKVFRSGIIDTIMKFAKFKQDQLLKKTDGSGKKSRINGITKLDDANNAGTKNGGKCTLI 513

Query: 69   LTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQ 128
            LTEGDSAK+LA++GLSVVGRD++GVFPLRGKLLNVREA++ QI  N EI  IK+ILGLQ 
Sbjct: 514  LTEGDSAKSLAVSGLSVVGRDNFGVFPLRGKLLNVREATHAQITGNAEISAIKQILGLQH 573

Query: 129  NKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA 188
             K Y +  +LRYGHLMIM DQDHDGSHIKGL+INF+  FWPSLL +P F++EF TPI+RA
Sbjct: 574  GKVYEDASTLRYGHLMIMTDQDHDGSHIKGLIINFLDHFWPSLLYIPGFLLEFITPIVRA 633

Query: 189  FHSNG---TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHR 245
                G    ++SF+++PE+E W+E + +   GW  KY+KGLGTST  + +EYF D+ KH 
Sbjct: 634  TKGKGHNKQEISFFTIPEFEQWKE-VNSGGRGWTTKYFKGLGTSTTADAKEYFSDMNKHL 692

Query: 246  KDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFS 305
            K F   DD     I+MAF+KKKA+ RK W+  F+PG Y DH  + I+  DF+N+ELILFS
Sbjct: 693  KPFCRLDDESRELIDMAFNKKKADSRKEWLGRFQPGTYMDHSVTEISLPDFINRELILFS 752

Query: 306  RADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLAST 365
             AD  RSIPS VDG KPGQRKILF  FK+ L  EIKV Q  GYV+EHSAYHHGEQSL +T
Sbjct: 753  MADNARSIPSSVDGFKPGQRKILFACFKRNLKSEIKVAQLAGYVAEHSAYHHGEQSLNAT 812

Query: 366  IIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLE 425
            I+ MAQ+F+GSNN+ +L+P GQFGTR  GGKD AS RYI+T L P+ R +FH +DD LL 
Sbjct: 813  IVNMAQNFIGSNNLGVLEPLGQFGTRLQGGKDAASPRYIFTNLTPLARTVFHPSDDPLLT 872

Query: 426  YLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVP 485
            YL +DG++IEP WY+P++P++LVNG++GIGTGWSS IPNYNPRDI+  + RL+  E +  
Sbjct: 873  YLVDDGQNIEPEWYLPVLPMLLVNGADGIGTGWSSSIPNYNPRDIVECLHRLMRHEELFE 932

Query: 486  MDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            + PWYRGF G IE+   E  Y V G + +ID  +  ITELPIR WTQ YK+ LE+   G+
Sbjct: 933  IHPWYRGFSGKIERETPE-RYKVTGCIRKIDSNTVEITELPIRTWTQSYKEQLEAWLTGT 991

Query: 546  PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
               +   I+D+++   D+ V   + +  + +++   EGL K+FKL +++S SN+  FD E
Sbjct: 992  EK-QTAWIKDYKEYHTDSKVHFIVTLTDQAMSLAESEGLEKRFKLISSVSVSNIVCFDLE 1050

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I+KY+  + I+++F+ LRL YY++RK ++L+        L++KVRF+  +++G++VV 
Sbjct: 1051 GRIRKYDGVQDIIKDFYELRLSYYQKRKNHMLQTLTFEYERLESKVRFVTEIITGKLVVQ 1110

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
            NRK+ DLL EL  + +  +PKK        AG+                        R  
Sbjct: 1111 NRKRIDLLKELVTRKYKLIPKKK-------AGSEATNGSEGSDDANDGDESVQDDDPRQG 1163

Query: 726  YEYLLSMSIGTLTLESVQ 743
            Y+YLLSM I  LT E VQ
Sbjct: 1164 YDYLLSMPIWNLTWEKVQ 1181


>M0VXE2_HORVD (tr|M0VXE2) DNA topoisomerase 2 OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 881

 Score =  777 bits (2006), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 364/483 (75%), Positives = 416/483 (86%), Gaps = 2/483 (0%)

Query: 13  VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
           V++SG++++LLSWA+FK SK+LKKTDGTK   + GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 399 VSSSGVVNSLLSWAEFKLSKELKKTDGTKKTSIVGIPKLEDANDAGGKNSDKCTLILTEG 458

Query: 73  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
           DSAKALAMAG+ VVGRDHYGVFPLRGKLLNVREAS+KQ+M+N EIQNIKKILGLQ  K Y
Sbjct: 459 DSAKALAMAGIGVVGRDHYGVFPLRGKLLNVREASHKQLMENAEIQNIKKILGLQHEKNY 518

Query: 133 SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            + K LRYGHLMIM DQDHDGSHIKGLLINFIH  WPSLLKVPSF+VEF TPII+A    
Sbjct: 519 DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGK 578

Query: 193 GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            T   FYSMP+YE+W+E+LG +A+ W IKYYKGLGTST +EGR+YF  + +H+KDFVW D
Sbjct: 579 -TVEPFYSMPDYEAWKESLGTSASSWTIKYYKGLGTSTAEEGRDYFEQITRHKKDFVWAD 637

Query: 253 DY-DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
           D  DG AIE+AFSKKK  +RK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 638 DKEDGDAIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 697

Query: 312 SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
           SIPS+VDG KPGQRKILFCSFKK L KE KV QFIGYVSEHSAYHHGEQSLASTI+GMAQ
Sbjct: 698 SIPSMVDGFKPGQRKILFCSFKKNLIKESKVAQFIGYVSEHSAYHHGEQSLASTIVGMAQ 757

Query: 372 DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
           DFVGSNNINLL+P GQFGTRN GGKD AS+RYI+T LNPITR +F ++DD LL YLNEDG
Sbjct: 758 DFVGSNNINLLEPRGQFGTRNAGGKDAASARYIFTRLNPITRLIFPKDDDVLLNYLNEDG 817

Query: 432 RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
           +SIEP+WY+PIIP+VLVNGSEGIGTGWS+Y+PNYNPRDIIAN++RLLN E +VPM PWYR
Sbjct: 818 QSIEPTWYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNGEAIVPMVPWYR 877

Query: 492 GFK 494
           GFK
Sbjct: 878 GFK 880


>L0P818_PNEJ8 (tr|L0P818) DNA topoisomerase 2 OS=Pneumocystis jiroveci (strain SE8)
            GN=PNEJI1_003373 PE=3 SV=1
          Length = 1482

 Score =  774 bits (1998), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 397/731 (54%), Positives = 516/731 (70%), Gaps = 18/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + I++ +L  A  K  + +KKTDG+K  R+ G+ KLEDAN AG +   KCTLILTEG
Sbjct: 458  VLKTPIMEKILDTAQKKADQLMKKTDGSKKMRITGLPKLEDANKAGTKEGHKCTLILTEG 517

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LAM+G+ VVGRD++GV+PLRGKLLNVREAS++QI  N EI  IK+I+GLQ  K Y
Sbjct: 518  DSAKSLAMSGIGVVGRDYFGVYPLRGKLLNVREASHEQISKNAEINAIKQIMGLQHKKVY 577

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++   LRYGHLMIM DQDHDGSHIKGL+IN++ S +PSLL++P F++EF TPI++A    
Sbjct: 578  TSTSELRYGHLMIMTDQDHDGSHIKGLIINYLESSFPSLLEIPGFLIEFITPIVKATKGT 637

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K +F+++PEYE W+E++ +NA GWKIKYYKGLGTS   + ++YF DL  H K+F    
Sbjct: 638  QEK-TFFTIPEYEYWKESV-DNAKGWKIKYYKGLGTSYGNDVKKYFSDLDTHLKEFHSIR 695

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I+MAFSKKKA++RK W+R F+PG Y DH   +I   DF+NKELILFS AD  RS
Sbjct: 696  EGDKELIDMAFSKKKADERKEWLRLFKPGTYMDHTLDKIPISDFINKELILFSMADNIRS 755

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDGLKPGQRK++F  FK+KL  EIKV Q  GY+SEH+AYHHGEQSL  TIIG+AQ 
Sbjct: 756  IPSVVDGLKPGQRKVIFGCFKRKLKSEIKVAQLSGYISEHTAYHHGEQSLTQTIIGLAQT 815

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINL+KPNGQFGTR  GGKD AS RYI+TEL+P+TR +F E+DD LL YLNEDG+
Sbjct: 816  FVGSNNINLMKPNGQFGTRLQGGKDAASPRYIFTELSPLTRKIFVESDDALLNYLNEDGQ 875

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+PIIPL+LVNG EGIGTGWSSYIPN+NP D++ N+RR++N E + PM PWYRG
Sbjct: 876  SIEPLWYVPIIPLILVNGCEGIGTGWSSYIPNFNPIDLVNNIRRMMNGEKLEPMHPWYRG 935

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G IEK   +  Y ++G + +ID+ +  ITELPIR WTQD K+FLE    GS  V+ P 
Sbjct: 936  FNGSIEKQGDK--YKISGCIRQIDDTTVEITELPIRFWTQDMKEFLELSVVGSDKVQ-PF 992

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+ +   D +V   I++  + +A  + +GL +KFKL    + +NM  FD+ G+IKKY 
Sbjct: 993  IKDYSEYHTDTVVHFIIKLTEKGMAESLAQGLEEKFKLIKIQNMTNMVAFDSSGRIKKYN 1052

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            + E+IL EF+ +RL +Y++RK Y++   E     L N+VRF+  V++ E    NRK+ DL
Sbjct: 1053 SVEEILLEFYNIRLQFYQKRKDYLVNELESQYNKLSNQVRFVKMVINKEQDFLNRKRKDL 1112

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            L +L+ KGF P P   K+    V  A                           Y+YLLSM
Sbjct: 1113 LDDLKLKGFIPFP---KNKHISVDNATETSNNLAENDDDDATG----------YDYLLSM 1159

Query: 733  SIGTLTLESVQ 743
             + +LT E V+
Sbjct: 1160 PLWSLTAEKVE 1170


>M0VXE3_HORVD (tr|M0VXE3) Uncharacterized protein OS=Hordeum vulgare var.
           distichum PE=4 SV=1
          Length = 546

 Score =  773 bits (1996), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 364/483 (75%), Positives = 416/483 (86%), Gaps = 2/483 (0%)

Query: 13  VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
           V++SG++++LLSWA+FK SK+LKKTDGTK   + GI KLEDANDAGG+NSDKCTLILTEG
Sbjct: 64  VSSSGVVNSLLSWAEFKLSKELKKTDGTKKTSIVGIPKLEDANDAGGKNSDKCTLILTEG 123

Query: 73  DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
           DSAKALAMAG+ VVGRDHYGVFPLRGKLLNVREAS+KQ+M+N EIQNIKKILGLQ  K Y
Sbjct: 124 DSAKALAMAGIGVVGRDHYGVFPLRGKLLNVREASHKQLMENAEIQNIKKILGLQHEKNY 183

Query: 133 SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            + K LRYGHLMIM DQDHDGSHIKGLLINFIH  WPSLLKVPSF+VEF TPII+A    
Sbjct: 184 DSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHKEWPSLLKVPSFLVEFITPIIKATKGK 243

Query: 193 GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            T   FYSMP+YE+W+E+LG +A+ W IKYYKGLGTST +EGR+YF  + +H+KDFVW D
Sbjct: 244 -TVEPFYSMPDYEAWKESLGTSASSWTIKYYKGLGTSTAEEGRDYFEQITRHKKDFVWAD 302

Query: 253 DY-DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
           D  DG AIE+AFSKKK  +RK W+ N++PG   D    RI Y DF+NKELILFS ADL+R
Sbjct: 303 DKEDGDAIELAFSKKKIAERKDWLTNYQPGTCLDQREKRIKYSDFINKELILFSMADLER 362

Query: 312 SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
           SIPS+VDG KPGQRKILFCSFKK L KE KV QFIGYVSEHSAYHHGEQSLASTI+GMAQ
Sbjct: 363 SIPSMVDGFKPGQRKILFCSFKKNLIKESKVAQFIGYVSEHSAYHHGEQSLASTIVGMAQ 422

Query: 372 DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
           DFVGSNNINLL+P GQFGTRN GGKD AS+RYI+T LNPITR +F ++DD LL YLNEDG
Sbjct: 423 DFVGSNNINLLEPRGQFGTRNAGGKDAASARYIFTRLNPITRLIFPKDDDVLLNYLNEDG 482

Query: 432 RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
           +SIEP+WY+PIIP+VLVNGSEGIGTGWS+Y+PNYNPRDIIAN++RLLN E +VPM PWYR
Sbjct: 483 QSIEPTWYMPIIPMVLVNGSEGIGTGWSTYVPNYNPRDIIANLKRLLNGEAIVPMVPWYR 542

Query: 492 GFK 494
           GFK
Sbjct: 543 GFK 545


>M1V3P5_CYAME (tr|M1V3P5) DNA topoisomerase 2 OS=Cyanidioschyzon merolae strain 10D
            GN=CYME_CMB013C PE=3 SV=1
          Length = 1576

 Score =  771 bits (1992), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 399/824 (48%), Positives = 529/824 (64%), Gaps = 45/824 (5%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
            S I+  +L +A F+Q  +LKKTDG K QR+ GI KL+DAN AG R S KCTLILTEGDSA
Sbjct: 399  SDIIGNVLEFARFRQDAELKKTDGGKRQRVLGIPKLDDANKAGTRESAKCTLILTEGDSA 458

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYS-- 133
            KALA++GLSVVGRD+YGVFPLRGKLLNVREA++KQIM+N EI  +KKILGLQ  KEY   
Sbjct: 459  KALAISGLSVVGRDYYGVFPLRGKLLNVREATHKQIMENTEINLLKKILGLQHGKEYDQD 518

Query: 134  NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNG 193
            +V+ LRYGH+MIM DQDHDGSHIKGLL+NF H FWPSLL++P F++EF TPI++A    G
Sbjct: 519  SVRQLRYGHVMIMTDQDHDGSHIKGLLVNFFHHFWPSLLRIPGFLLEFITPIVKATAKRG 578

Query: 194  TKLS---FYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             +L    F+++PEY+ WR++  ++  GW IKYYKGLGTST  E R YF +L +H+  FVW
Sbjct: 579  ERLEEVVFFTIPEYQQWRQS-QSSLRGWTIKYYKGLGTSTAAEARTYFSNLSRHQIPFVW 637

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
            ++  D  +IE+AFSK K ++RK W+   + G Y DH A  + Y +FV+KEL+LFS AD  
Sbjct: 638  QNHADYESIELAFSKHKVQERKDWLAAHKLGTYFDHAADTLTYANFVHKELVLFSLADNA 697

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIP ++DGLKP QRK+LF  FK+KL++EIKV Q  GYVSEH+AYHHGE SL +TIIG+A
Sbjct: 698  RSIPCLIDGLKPSQRKVLFACFKRKLYQEIKVAQLAGYVSEHAAYHHGEASLMATIIGLA 757

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q+FVGSNN+NLL P GQFGTR  GGKD AS RYI+T L P+ R LF E DD LLEYL ED
Sbjct: 758  QNFVGSNNLNLLVPAGQFGTRLSGGKDAASPRYIFTCLAPVARALFPEADDVLLEYLEED 817

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL--------NDET 482
            G SIEP WY P+IPLVLVNG+EGIGTGWS+ IP +NPRD++  +R +L         D  
Sbjct: 818  GLSIEPKWYCPVIPLVLVNGAEGIGTGWSTNIPCHNPRDLVRILRSMLLESHGALDADNE 877

Query: 483  MVPMDPWYRGFKG-IIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI 541
               + PWYRGF+G I+        Y V G +    +   RI ELP+R WTQ YK++LE++
Sbjct: 878  SATLVPWYRGFRGSIVAVPHHPTNYEVFGCMARSSDGRVRIRELPLRTWTQPYKEWLETL 937

Query: 542  TDGSPNVKD------------------PLIEDFRQNGDDAMVDIEIR-MKLEKIAMIMQE 582
              G+ +                     P +++   N  + +VD  +      ++      
Sbjct: 938  VVGNSSTSSSSSGSGSSASSAAQQTSRPFLKEVADNSTETLVDFTLHWANGAELEQADAA 997

Query: 583  GLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFER 642
             L KK  L+ ++ST+NM LFD+ G+I++Y+  +QIL EF+ +RL+ Y +R+ +I+   ER
Sbjct: 998  ALFKKLHLSGSLSTANMVLFDSNGRIRRYDTIQQILVEFYQMRLELYRKRQAWIVRALER 1057

Query: 643  LLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSA--EPQVAGAXX 700
             L+ LDNKVRFI+ V+  +I+++NRK+++LL EL Q+ F  +P  G +A  E +V+ A  
Sbjct: 1058 ELIRLDNKVRFIMAVIENQIIIANRKRSELLDELHQRNFARLP-TGNNADREQRVSEAAS 1116

Query: 701  XXXXXXXXXXXXXXXXXXXXXKRGD---YEYLLSMSIGTLTLESVQXXXXXXXXXXXXXX 757
                                    D   Y+YLLSM + +LT E VQ              
Sbjct: 1117 GDGTPDGTSSDQVGGNGVHADHPKDATGYDYLLSMPLWSLTRERVQELQRQHQEKAAELA 1176

Query: 758  XXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRT 801
               AT    +W+             D + A+D     +Q +KRT
Sbjct: 1177 RMQATRPSELWLDDLTRLEQILDRIDSELAQD-----AQDAKRT 1215


>M2Y981_GALSU (tr|M2Y981) DNA topoisomerase 2 OS=Galdieria sulphuraria
            GN=Gasu_00250 PE=3 SV=1
          Length = 1396

 Score =  771 bits (1990), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 382/678 (56%), Positives = 493/678 (72%), Gaps = 8/678 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S IL+ +LS+A  KQ+ +LKKTDG K +++ GI KL+DAN AG + S  CTLIL
Sbjct: 374  MKKVMKSSILENVLSFAKMKQTSELKKTDGGKAKKILGIPKLDDANYAGTKESFYCTLIL 433

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAKALA++GLSVVGRD+YGVFPLRGKLLNVREAS+KQIM+N EI N+KKILGLQ  
Sbjct: 434  TEGDSAKALAVSGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEINNLKKILGLQHG 493

Query: 130  KEYSN--VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
            K Y +  +K+LRYGH++IM DQD+DGSHIKGLLINF H FWPSLL+V  F+ EF TPI++
Sbjct: 494  KVYDDETIKTLRYGHVLIMTDQDNDGSHIKGLLINFFHHFWPSLLEVKGFLQEFITPIVK 553

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNA-TGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
            A   N   ++F+++PEY++WR +L      GW IKYYKGLGTST  E +EYF  L  H  
Sbjct: 554  ASKGNQV-VTFFTIPEYKTWRTSLEQETLKGWTIKYYKGLGTSTAAEAKEYFSHLDLHVI 612

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
            DF+W  ++D  AI+MAFSK++ ++RK W+ + +P  Y DH+A  + Y +FVNKELILFS 
Sbjct: 613  DFIWSGEHDMVAIDMAFSKQRVQERKEWLADVDPDTYFDHIADDLTYSNFVNKELILFSL 672

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
            +D  RSIPSV+DGLKP QRK+LF  FKKKL ++IKV Q  GY++E++AYHHGE SL +TI
Sbjct: 673  SDNARSIPSVIDGLKPSQRKVLFGCFKKKLTRDIKVAQLAGYIAENAAYHHGEMSLMATI 732

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            +G+AQ+FVG+ NINLL P+GQFGTR  GGKD AS+RYI+T L PITR LF E DD +L Y
Sbjct: 733  VGLAQNFVGACNINLLVPSGQFGTRLQGGKDAASARYIFTRLAPITRYLFPEADDAVLHY 792

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            L EDG SIEP++Y PIIPLVLVNG+EGIGTGWS+ +P YNP+D+I N+RRL++      M
Sbjct: 793  LEEDGLSIEPNYYCPIIPLVLVNGAEGIGTGWSTNVPCYNPKDVIENIRRLIHGHEPHTM 852

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PWYRGF+G I  S     Y + G V  + +   RITELP++ WT  YK++LESI   S 
Sbjct: 853  HPWYRGFRGSICFSG-SSTYDIYGKVYRVRDHLVRITELPLKTWTTPYKEWLESIMLSSE 911

Query: 547  NVKD---PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFD 603
              K      I++      + +VD  I +  E       +G  KKFKL +T+STSNM LF+
Sbjct: 912  QHKSGETSFIKELFDRSTERLVDFLINLHEEAYKQCETQGFHKKFKLGSTLSTSNMVLFN 971

Query: 604  AEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIV 663
            AEGKI+KY++P  +L+EFF +RL  YE RKQY+L+     +  L+N+VRFIL V+ GEI 
Sbjct: 972  AEGKIQKYDDPIDMLKEFFHIRLRLYESRKQYLLQELTVQVEKLENRVRFILQVIQGEIK 1031

Query: 664  VSNRKKADLLMELQQKGF 681
            V+N K+ DL++ L +  F
Sbjct: 1032 VANVKRKDLIVTLTKHHF 1049


>D8QKJ8_SCHCM (tr|D8QKJ8) DNA topoisomerase 2 OS=Schizophyllum commune (strain H4-8
            / FGSC 9210) GN=SCHCODRAFT_17796 PE=3 SV=1
          Length = 1494

 Score =  770 bits (1989), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 377/684 (55%), Positives = 498/684 (72%), Gaps = 8/684 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S +++ +L+WA FK  + +KKTDG+K  RL G+ KL DAN+AG + +  CTLIL
Sbjct: 465  MKKVQKSPLVENILNWAKFKADQQIKKTDGSKRSRLTGLPKLSDANNAGTKYAKDCTLIL 524

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAKALA+AGL VVGRD+YGVFPLRGKLLNVREA + QIM NEEIQNIKKILGLQ N
Sbjct: 525  TEGDSAKALAIAGLGVVGRDNYGVFPLRGKLLNVREARHDQIMKNEEIQNIKKILGLQHN 584

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKV-PSFMVEFTTPIIRA 188
            K+Y+++ SLRYG LMIM DQDHDGSHIKGL++NF+  F+PSLLK+ P+F++EF TPI+R 
Sbjct: 585  KDYTDIASLRYGKLMIMTDQDHDGSHIKGLILNFLDHFYPSLLKLDPAFLLEFITPIVRV 644

Query: 189  FHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
               N  K  F+++PEYE W E   + A  W  KYYKGLGTS   + R+YF    KH   F
Sbjct: 645  TKGNQRK-DFFTLPEYERWLETTPD-ARKWSAKYYKGLGTSKDSDARDYFSHTEKHVIPF 702

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                + D   I++AFSKKKA+DRK W+R  +PG + +H    I   DF+NKELILFS AD
Sbjct: 703  AQTQEGDRELIDLAFSKKKADDRKEWLRTCKPGTFLNHDVDEIPISDFINKELILFSMAD 762

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV DGLKPGQRKI++  FK+KL KEIKV Q +GYVSEH+AYHHGEQSL  TI+ 
Sbjct: 763  NIRSIPSVADGLKPGQRKIIWGCFKRKLKKEIKVAQLVGYVSEHAAYHHGEQSLTMTIVN 822

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQD+VGSNNINLL PNGQ+GTR+ GGKDHA++RYI+TEL+P+TR LF+  D+ LL+   
Sbjct: 823  LAQDYVGSNNINLLMPNGQYGTRDQGGKDHAAARYIFTELSPLTRSLFNTADEPLLKQQK 882

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            ED + +EP +Y+PIIP+VLVNG++GIGTGWS+ IP+YNP DI+AN+RRL++ E  VPM P
Sbjct: 883  EDNQPVEPEYYMPIIPMVLVNGADGIGTGWSTSIPSYNPTDIVANIRRLMDGEEQVPMFP 942

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G I KS  +  Y V G   ++++    ITELPI KWTQ++K  LE++   S   
Sbjct: 943  WWRGFNGEI-KSTGKNKYDVTGIARKLNDTQVEITELPIHKWTQNFKAELETMM-VSEKG 1000

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
            + P    + ++ D+  V   I M   ++    ++G ++ FKLT+ IST+NM  F+ +GKI
Sbjct: 1001 EAPT---YTEHHDNTNVHFIITMSATELKKAEEQGFVEYFKLTSKISTANMIAFNFDGKI 1057

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
             KY++PE+I+EEF+P RL YY++RK Y+ +  +  L  L+N+ RFI  +V  +++VSNRK
Sbjct: 1058 TKYDSPEEIVEEFYPQRLMYYQKRKDYLADELQVQLSRLNNQARFIQMIVDRQLIVSNRK 1117

Query: 669  KADLLMELQQKGFTPMPKKGKSAE 692
            K D++ +L++  F P PK  K+ E
Sbjct: 1118 KVDIVADLRKHDFRPFPKIAKAKE 1141


>B6K8S1_TOXGO (tr|B6K8S1) DNA topoisomerase 2 OS=Toxoplasma gondii GN=TGME49_112230
            PE=3 SV=1
          Length = 1687

 Score =  769 bits (1986), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 383/768 (49%), Positives = 511/768 (66%), Gaps = 13/768 (1%)

Query: 22   LLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALAMA 81
            LL + + ++   + KT G   +RL GI KLEDANDAGGR+S  CTLILTEGDSAK   +A
Sbjct: 511  LLVFVELRKQMKVGKTKGR--ERLAGIPKLEDANDAGGRHSQDCTLILTEGDSAKTSCLA 568

Query: 82   GLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKSLRYG 141
            GLSVVGRD YGVFPLRGKLLNVR+AS KQ+ +N+EIQNI KI+GLQ N    + + LRYG
Sbjct: 569  GLSVVGRDRYGVFPLRGKLLNVRDASFKQLTENKEIQNILKIVGLQVNDRTEDTRGLRYG 628

Query: 142  HLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTKLSFYSM 201
             +MIM DQDHDGSHIKGLLIN +H +WP LLK   F+  F+TPI++   +N  K +FY++
Sbjct: 629  SVMIMTDQDHDGSHIKGLLINMMHHYWPQLLKCRGFLKAFSTPIVKVSKNNVEK-AFYTI 687

Query: 202  PEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEM 261
            PEYE W+ +   N TGWKIKYYKGLGTST +E +EYF DL KH+ DFVW   +DG  I+M
Sbjct: 688  PEYEQWKRSC--NTTGWKIKYYKGLGTSTDREFKEYFNDLDKHQIDFVWSGQHDGELIDM 745

Query: 262  AFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLK 321
            AF+KK+AEDRK W+++++ G + DH AS ++Y DFVNKELILFSR D +RSIP +VDG K
Sbjct: 746  AFNKKRAEDRKRWLQSYQEGTFVDHNASSLSYSDFVNKELILFSRYDTERSIPQLVDGWK 805

Query: 322  PGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINL 381
            PGQRK+LF   KK +  E+KV Q  GYVSE SAYHHGE SL  TI+ MAQ FVGSNN+N 
Sbjct: 806  PGQRKVLFACIKKNMKHELKVAQLAGYVSEVSAYHHGEASLQQTIVTMAQRFVGSNNLNF 865

Query: 382  LKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIP 441
            L+P GQFG+R  GGKD +++RYI+T L   TR +FHE DD +LEY  E+G+ IEP  Y+P
Sbjct: 866  LEPVGQFGSRKEGGKDASAARYIFTRLAFYTRLVFHEADDPILEYEYEEGQRIEPKMYVP 925

Query: 442  IIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSA 501
            +IP VL+NGSEGIGTGWSS++PNYNPRD+I N+RR ++ E M  M PWYRGF+G IE++A
Sbjct: 926  VIPTVLINGSEGIGTGWSSFVPNYNPRDVIENLRRYIDGEEMQRMTPWYRGFRGRIEENA 985

Query: 502  KEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV--KDPLIEDFRQN 559
               G+   G V    E ++ ITELPI++WTQDYK++LE   +  P    +D LI D+R  
Sbjct: 986  AGTGFETIGLVRRCGEDTYEITELPIKRWTQDYKEWLE---ENLPTAEKRDTLIADYRDC 1042

Query: 560  GDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILE 619
                 +   +++  E++    +EGL K FKL +++S +N+ LFD  G++++Y N  +I++
Sbjct: 1043 SSHEEIHFTVKVGEERVERPEREGLEKYFKLKSSLSITNLTLFDPHGRVQRYANELEIIK 1102

Query: 620  EFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQK 679
            EF P+RL++Y RRK Y L   E+   +L N++RFIL VV+GE++++N++K  L+ EL  +
Sbjct: 1103 EFAPIRLEFYHRRKAYCLAMLEKARRILSNRLRFILAVVNGELIINNKRKKALIEELFSQ 1162

Query: 680  GFTPMPKKGKSAEPQVAGAXXXXXX---XXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGT 736
            G+ PM +   +A   +  A                              Y+YLL M + +
Sbjct: 1163 GYDPMKEIEDAANAGIRAALKRDVTVDDEALAEGGEEEEEIVAGCTAKHYDYLLGMPMWS 1222

Query: 737  LTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDG 784
            LTLE V+                  T  +++W             QDG
Sbjct: 1223 LTLEKVEDLRGEMRQKELELEELRHTSVQTLWKRDLDALVAALDKQDG 1270


>L8GML2_ACACA (tr|L8GML2) DNA topoisomerase 2 OS=Acanthamoeba castellanii str. Neff
            GN=ACA1_366710 PE=3 SV=1
          Length = 1559

 Score =  769 bits (1985), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 386/759 (50%), Positives = 507/759 (66%), Gaps = 6/759 (0%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             V    I++ ++ +A FKQ + L +  G+K  R+ GIVKL+DAN+AGG+N+DKCTLILTE
Sbjct: 419  VVKKCAIVENVVQFAQFKQKQQLGRKGGSKKTRVSGIVKLDDANEAGGKNADKCTLILTE 478

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK LA++GLSVVGRD YGVFPL+GK LNVREA++KQIMDN E  +I +ILGL+ N +
Sbjct: 479  GDSAKTLAVSGLSVVGRDRYGVFPLKGKPLNVREATHKQIMDNVEFGHIMEILGLKPNIK 538

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y + K LRYG LMIM DQDHDGSHIKGL+INF+H FWP LLK P F+ EF TPI++A   
Sbjct: 539  YESTKGLRYGRLMIMTDQDHDGSHIKGLVINFVHHFWPDLLKTPGFLTEFITPIVKATKK 598

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              T +SFY+M EYE+W+E   NN  GWKIKYYKGLGTS+ QE +EYF +L +H+ DF W 
Sbjct: 599  KET-ISFYTMTEYETWKEE-NNNGQGWKIKYYKGLGTSSAQEAKEYFSELQRHKIDFAWG 656

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             D DG AI+MAFSKK+ EDRK WI  FEPG + D     + Y DF++KELI FS AD  R
Sbjct: 657  GDEDGDAIDMAFSKKRVEDRKTWISKFEPGTFLDQDVDELPYSDFIHKELIHFSIADCAR 716

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRKIL+    K + +EI+V Q  G VS HSAYHHGE+SL   I+ MA 
Sbjct: 717  SIPSLVDGLKPGQRKILYTCLSKNIKEEIRVAQLSGSVSLHSAYHHGEESLNKAIVAMAH 776

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            +FVGSNNINLL P G FG+R  GGKD AS+RY++T L  ITR +FH +DDKLL YL +DG
Sbjct: 777  NFVGSNNINLLFPAGSFGSRLHGGKDAASARYLHTRLCEITRTIFHPDDDKLLNYLEDDG 836

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
              +EP +Y+PIIPL LVNG EGIGTGWS+++PNYNPRDI+ N++R+L +ET   M PWYR
Sbjct: 837  LPVEPEFYVPIIPLSLVNGGEGIGTGWSTFVPNYNPRDIVDNIKRMLRNETPKEMIPWYR 896

Query: 492  GFKG--IIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
             F+G  + +K  K   Y + G   + D  +  ITELPI  WTQ +K+FLE++       +
Sbjct: 897  AFEGQLVEDKDGKTPRYRILGIWNKPDPHTLEITELPIGVWTQGFKKFLETLLQPEKKRQ 956

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
              L++D+ ++  D+ V   I +  ++ ++  +  + K+FKL+  IS +NMHLFD  G I 
Sbjct: 957  YALVKDYTEHHTDSKVHFVITL-TDEASVFDESEIEKQFKLSKYISMNNMHLFDRNGHIA 1015

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            +Y +   +L+EF+ +RL++Y++RK +++    + L  LDN+VRFILGV+  EIVV+NRKK
Sbjct: 1016 RYGSCMSVLQEFYDVRLEFYDKRKAHLIGTLNKQLSKLDNQVRFILGVIKKEIVVNNRKK 1075

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
             +LL +L+  GF       K  + +                           + G Y YL
Sbjct: 1076 VELLKQLEDMGFDKFENDAKEKKKKATSGKAKKGDAEDDDDEEGDSKSVKKAETG-YNYL 1134

Query: 730  LSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
            L M I  LT+E VQ                 ATP K +W
Sbjct: 1135 LGMPIWNLTMERVQKLQQQRDEKQEELDTLKATPIKDLW 1173


>B9PK68_TOXGO (tr|B9PK68) DNA topoisomerase 2 OS=Toxoplasma gondii GN=TGGT1_088480
            PE=3 SV=1
          Length = 1688

 Score =  768 bits (1984), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 383/768 (49%), Positives = 510/768 (66%), Gaps = 13/768 (1%)

Query: 22   LLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALAMA 81
            L  + + ++   + KT G   +RL GI KLEDANDAGGR+S  CTLILTEGDSAK   +A
Sbjct: 511  LFVFVELRKQMKVGKTKGR--ERLAGIPKLEDANDAGGRHSQDCTLILTEGDSAKTSCLA 568

Query: 82   GLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKSLRYG 141
            GLSVVGRD YGVFPLRGKLLNVR+AS KQ+ +N+EIQNI KI+GLQ N    + + LRYG
Sbjct: 569  GLSVVGRDRYGVFPLRGKLLNVRDASFKQLTENKEIQNILKIVGLQVNDRTEDTRGLRYG 628

Query: 142  HLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTKLSFYSM 201
             +MIM DQDHDGSHIKGLLIN +H +WP LLK   F+  F+TPI++   +N  K +FY++
Sbjct: 629  SVMIMTDQDHDGSHIKGLLINMMHHYWPQLLKCRGFLKAFSTPIVKVSKNNVEK-AFYTI 687

Query: 202  PEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEM 261
            PEYE W+ +   N TGWKIKYYKGLGTST +E +EYF DL KH+ DFVW   +DG  I+M
Sbjct: 688  PEYEQWKRSC--NTTGWKIKYYKGLGTSTDREFKEYFNDLDKHQIDFVWSGQHDGELIDM 745

Query: 262  AFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLK 321
            AF+KK+AEDRK W+++++ G + DH AS ++Y DFVNKELILFSR D +RSIP +VDG K
Sbjct: 746  AFNKKRAEDRKRWLQSYQEGTFVDHNASSLSYSDFVNKELILFSRYDTERSIPQLVDGWK 805

Query: 322  PGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINL 381
            PGQRK+LF   KK +  E+KV Q  GYVSE SAYHHGE SL  TI+ MAQ FVGSNN+N 
Sbjct: 806  PGQRKVLFACIKKNMKHELKVAQLAGYVSEVSAYHHGEASLQQTIVTMAQRFVGSNNLNF 865

Query: 382  LKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIP 441
            L+P GQFG+R  GGKD +++RYI+T L   TR +FHE DD +LEY  E+G+ IEP  Y+P
Sbjct: 866  LEPVGQFGSRKEGGKDASAARYIFTRLAFYTRLVFHEADDPILEYEYEEGQRIEPKMYVP 925

Query: 442  IIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSA 501
            +IP VL+NGSEGIGTGWSS++PNYNPRD+I N+RR ++ E M  M PWYRGF+G IE++A
Sbjct: 926  VIPTVLINGSEGIGTGWSSFVPNYNPRDVIENLRRYIDGEEMQRMTPWYRGFRGRIEENA 985

Query: 502  KEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV--KDPLIEDFRQN 559
               G+   G V    E S+ ITELPI++WTQDYK++LE   +  P    +D LI D+R  
Sbjct: 986  AGTGFETIGLVRRCGEDSYEITELPIKRWTQDYKEWLE---ENLPTAEKRDTLIADYRDC 1042

Query: 560  GDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILE 619
                 +   +++  E++    +EGL K FKL +++S +N+ LFD  G++++Y N  +I++
Sbjct: 1043 SSHEEIHFTVKVGEERVERPEREGLEKYFKLKSSLSITNLTLFDPHGRVQRYANELEIIK 1102

Query: 620  EFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQK 679
            EF P+RL++Y RRK Y L   E+   +L N++RFIL VV+GE++++N++K  L+ EL  +
Sbjct: 1103 EFAPIRLEFYHRRKAYCLAMLEKARRILSNRLRFILAVVNGELIINNKRKKALIEELFSQ 1162

Query: 680  GFTPMPKKGKSAEPQVAGAXXX---XXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGT 736
            G+ PM +   +A   +  A                              Y+YLL M + +
Sbjct: 1163 GYDPMKEIEDAANAGIRAALKRDVIVDDEALAEGGEEEEEIVAGCTAKHYDYLLGMPMWS 1222

Query: 737  LTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDG 784
            LTLE V+                  T  +++W             QDG
Sbjct: 1223 LTLEKVEDLRGEMRQKELELEELRHTSVQTLWKRDLDALVAALDKQDG 1270


>E7A2Y1_SPORE (tr|E7A2Y1) DNA topoisomerase 2 OS=Sporisorium reilianum (strain
            SRZ2) GN=sr14492 PE=3 SV=1
          Length = 1513

 Score =  768 bits (1982), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 384/731 (52%), Positives = 523/731 (71%), Gaps = 17/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D ++S+A FKQ + LKKTDG K  R+  I KLEDAN+AGGR +  CTLILTEG
Sbjct: 492  VIKSGVVDNIVSFARFKQDQALKKTDGHKRTRITNIPKLEDANNAGGRKAKDCTLILTEG 551

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AG+  VGRD+YGVFPLRGKLLNVREAS+ QIM N EI+ IK+ILGLQ  K+Y
Sbjct: 552  DSAKSLAVAGIVEVGRDNYGVFPLRGKLLNVREASHDQIMKNAEIKAIKEILGLQHGKQY 611

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYG +MIM DQDHDGSHIKGL+INF+  F+PSLL++P F+VEF TPI++     
Sbjct: 612  LDVNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPGFLVEFITPIVKC-RKG 670

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              +LSF+++PEYE+WR++  N   GW IKYYKGLGTS PQ+ ++YFR L KH+  F    
Sbjct: 671  KQELSFFTIPEYETWRDS-HNGGKGWHIKYYKGLGTSDPQDAKKYFRALEKHKLPFDVTQ 729

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I++AF+KKKA+DRK W+R F PG Y DH   RI Y DF+NKELILFS AD  RS
Sbjct: 730  EGDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNTDRIPYADFINKELILFSMADNLRS 789

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDGLKPGQRK+ +  F +K   E+KV   +G+V   +AYHHG+ +L  TI+G+AQ+
Sbjct: 790  IPSVVDGLKPGQRKVFYVMFDRKSNAELKVNTLVGHVMGQAAYHHGDAALVMTIVGLAQN 849

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNN+NLL+P GQFGTR LGGKD AS RYI+T L  ITR LF + DD LL+YL++DG+
Sbjct: 850  FVGSNNVNLLEPRGQFGTRLLGGKDAASGRYIFTALPKITRALFPQADDALLDYLDDDGQ 909

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             +EP WYIP++P VL+NG+EGIGTGWS+ +PNYNP +I+AN+RR    E ++PM PW+RG
Sbjct: 910  KVEPHWYIPVVPQVLMNGAEGIGTGWSTSVPNYNPHEIVANLRRRTAGEDIIPMKPWFRG 969

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G +E+ +  G + V+G V +IDE+++ ITELPIR WT +YK+ LE     S   +   
Sbjct: 970  FTGDVEEFS-PGRFKVSGRVTQIDEKTWEITELPIRTWTSNYKESLEERIVSSEKAQ-AT 1027

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+++   ++ V+  + +  +  A I ++G    FKL+  IST+NM LFD +GKIKKY 
Sbjct: 1028 IKDYKEYHTESTVNFIVELTAKGQAEIAEKGADAFFKLSCQISTTNMVLFDQDGKIKKYS 1087

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PE+ILEEF+ LRL YY++RK+++++  + +   L N+ RF+  +++ ++VVSNRK+AD+
Sbjct: 1088 SPEEILEEFYLLRLSYYQKRKEHLVDQLKLMYDKLSNQARFVQMIINRQLVVSNRKRADI 1147

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L++  F P PK+GK++   +A                            D++YLL+M
Sbjct: 1148 VADLRKNDFRPFPKQGKAS---IAAEPEDDEPIDEEDISAD----------SDFDYLLNM 1194

Query: 733  SIGTLTLESVQ 743
            +I  LT E V+
Sbjct: 1195 AIYNLTKEKVE 1205


>B8C9P0_THAPS (tr|B8C9P0) DNA topoisomerase 2 (Fragment) OS=Thalassiosira
            pseudonana GN=TOP2 PE=3 SV=1
          Length = 1172

 Score =  763 bits (1971), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 393/771 (50%), Positives = 511/771 (66%), Gaps = 29/771 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V   G++D+++++A FK+ + LK+  GTK  +L GI KL+DAN AG   S  CTLI+TEG
Sbjct: 385  VDKCGVVDSIMAYAKFKEGQALKRKGGTKKNKLTGITKLDDANHAGTAKSKDCTLIITEG 444

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA++GLSVVGRD YGVFPL+GK LNVR+A++ QIM NEEI N+  I+GL+ +  Y
Sbjct: 445  DSAKSLAVSGLSVVGRDFYGVFPLKGKPLNVRDATHFQIMKNEEISNLVAIMGLKFDTTY 504

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
            +  N+KSLRYGHLMIM DQDHDGSHIKGL+INF+H FWPSLL +P F+++F TPI++   
Sbjct: 505  TEENIKSLRYGHLMIMTDQDHDGSHIKGLIINFLHKFWPSLLDIPDFLMQFITPIVKC-- 562

Query: 191  SNGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
            + G K  +F+++PEYE W+E  GN+A GW IKYYKGLGTST  E +EYF +L  H   F 
Sbjct: 563  TKGKKFHTFFTLPEYEEWKEGTGNDAKGWTIKYYKGLGTSTSSEAKEYFSNLDIHEIIFN 622

Query: 250  WEDDY---DGSA-IEMAFSKKKAEDRKVWIRNFEPG---NYRDHVASRINYKDFVNKELI 302
               D     GSA I+MAFSK K E+RK W+   E     NYRD   + +N+ +FVN+EL+
Sbjct: 623  EISDCIPSTGSALIDMAFSKSKVEERKKWLNRVEKDTFLNYRDAQRNGVNHSEFVNRELV 682

Query: 303  LFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSL 362
            LFS+ D  RSIP ++DG KP QRK+L+  FKKKL  EIKV Q  GY+ EHSAYHHG+ SL
Sbjct: 683  LFSQYDNVRSIPHIMDGFKPSQRKVLYACFKKKLKAEIKVAQLAGYIGEHSAYHHGDMSL 742

Query: 363  ASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDK 422
              TIIGMAQ + GSNN+NLL P+GQFGTR +GGKDHAS+RYI+T L  I R +FH +DD 
Sbjct: 743  NGTIIGMAQSYCGSNNLNLLYPSGQFGTRRMGGKDHASARYIFTRLEKIARAIFHPDDDA 802

Query: 423  LLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDET 482
            LL YLN+DG SIEP +Y+P+IP+VLVNGS+GIGTGWSS I N++PR++IAN+++++N E 
Sbjct: 803  LLNYLNDDGLSIEPEYYMPVIPMVLVNGSDGIGTGWSSTIQNHDPREVIANIKKMINGEE 862

Query: 483  MVPMDPWYRGFKGII--EKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLES 540
               M P + GF G I  E  ++EG YIV G +E   + +  ITELP+ KWTQ+YK FLE 
Sbjct: 863  PELMHPHFAGFTGEITAESGSREGSYIVEGKIERTGDTTLLITELPVGKWTQNYKAFLEG 922

Query: 541  ITDGSPNVKDPL-IEDFRQNGDDAMVDIEIRMKLEKIAMIM--QEGLLKKFKLTTTISTS 597
            +  G+   KDP  I DF++N  D  V   +    E I      + GLLKKFKL+TT+ST+
Sbjct: 923  LMSGTD--KDPSEISDFKENHTDTTVSFTVTATEENINKFEYGKGGLLKKFKLSTTMSTA 980

Query: 598  NMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGV 657
            NMHLF  +GKI KY     IL  FF  RL+YY +RK  +LE   R L V DNK RF+  V
Sbjct: 981  NMHLFSEDGKIVKYNGSVDILRTFFHHRLEYYVKRKDMLLEKLRRELKVYDNKARFVEEV 1040

Query: 658  VSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXX 717
              G++VVSNRK+++LL EL+ K +   PK+   AE                         
Sbjct: 1041 YKGDLVVSNRKRSELLFELRDKEYDIYPKESNQAETD---------DEDESMESVEENAS 1091

Query: 718  XXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
                 +G YEYLL M I +LT E  +                  T  +++W
Sbjct: 1092 DAELAKG-YEYLLGMKIWSLTFERAKELRRQKTEKAEDVEKLEGTSPEAIW 1141


>M5FVQ8_DACSP (tr|M5FVQ8) DNA topoisomerase II OS=Dacryopinax sp. (strain DJM 731)
            GN=DACRYDRAFT_54567 PE=4 SV=1
          Length = 1365

 Score =  762 bits (1967), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/735 (51%), Positives = 505/735 (68%), Gaps = 19/735 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  VA SGI++ +L +A FK  +  KKTDGTK  RL G+ KL DAN+AGGRN+ KC+LIL
Sbjct: 487  MKKVAKSGIVENVLEYAKFKADQAHKKTDGTKRSRLVGMAKLVDANNAGGRNASKCSLIL 546

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
             EGDSAK LA AGL+VVGRD++G+FPLRGKLLNVREA+++QIM N EIQ IKKI+GLQ N
Sbjct: 547  CEGDSAKTLAEAGLAVVGRDNFGIFPLRGKLLNVREANHEQIMKNAEIQAIKKIMGLQHN 606

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K Y +V SLRYG +MIM DQD DGSHIKGL+INF+  F+PSLLK+P F+VEF TPI+R  
Sbjct: 607  KVYDSVDSLRYGSIMIMTDQDFDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVRVT 666

Query: 190  HSNGTK-LSFYSMPEYESWRENLGNNATGWK-IKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            H    K  +F++MPEYE W E   ++   ++  KY+KGLGTS P++G EYF ++  H   
Sbjct: 667  HKRTRKRTTFFTMPEYEEWAEQHKHDKHLYEDPKYFKGLGTSGPEDGMEYFGNMETHLIP 726

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F    + +   I+MAFSKKK E RK W+RNF+PG Y DH    I Y DF+NKELILFS A
Sbjct: 727  FHPTQEGERELIDMAFSKKKVEARKDWLRNFKPGTYMDHSVDEITYDDFINKELILFSMA 786

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPS+ DGLKPG RK+LF  FK+ L  EIKV Q  GY+ EH+AYHHGEQSL STII
Sbjct: 787  DNIRSIPSMCDGLKPGHRKVLFGVFKRNLKNEIKVAQLAGYIGEHTAYHHGEQSLHSTII 846

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            GMAQ+FVG+NN+NLL P+G FG+R++GG+D A++RY+ T L  ITR +FH  DD +L YL
Sbjct: 847  GMAQNFVGANNLNLLIPSGGFGSRSMGGEDAAAARYLNTNLMAITRSVFHSADDNILTYL 906

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             EDG+ IEP +Y+PIIP+VLVNGS GIGTGWS+ IP++NP DI+AN+RR +  E + PM 
Sbjct: 907  MEDGKRIEPEFYLPIIPMVLVNGSSGIGTGWSTNIPSFNPVDIVANIRRYMRHEPLEPMS 966

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWYR F G  EK + EG ++ +G ++++D+ +  ITELPI +WTQ YK+ LES   G   
Sbjct: 967  PWYRNFLGSFEKVS-EGKFVCHGIIKKVDDYNVEITELPIGRWTQKYKEMLESWIMGDDK 1025

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
                 I+D+++      +   +++   ++     EGL K FKL   IST+NM  FDA+GK
Sbjct: 1026 TA-ATIKDYKEYHTTRHIRFTVQLSGTEMQKAEAEGLEKYFKLLEAISTTNMMCFDADGK 1084

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            ++K+ +PE ++E+F PLRL +Y++RK Y+ +     L  L+N+ RF+  ++  E+V+SNR
Sbjct: 1085 MRKFNSPEDLIEDFCPLRLKFYQKRKDYLADQLMVELEKLNNQARFVKMIIDRELVISNR 1144

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KK D++ EL++K   P PK  K+ E                                D++
Sbjct: 1145 KKVDIVAELRKKELKPFPKVSKAKEEGETEDVVEEEEPGSVT---------------DFD 1189

Query: 728  YLLSMSIGTLTLESV 742
            YLL M+I +LT E +
Sbjct: 1190 YLLGMAIYSLTQERI 1204


>K1VKL9_TRIAC (tr|K1VKL9) DNA topoisomerase 2 OS=Trichosporon asahii var. asahii
            (strain CBS 8904) GN=A1Q2_00925 PE=3 SV=1
          Length = 1525

 Score =  762 bits (1967), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/735 (51%), Positives = 513/735 (69%), Gaps = 30/735 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI++ +L++A FKQ + +KKTDG K  R+ GI KL+DAN AGGRN+ +CTLILTEG
Sbjct: 527  VAKSGIVENVLAFAKFKQDQAMKKTDGAKRSRIGGIAKLDDANWAGGRNASQCTLILTEG 586

Query: 73   DSAKALAMAGLSVV-GRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            DSAK++A++G+  + GRD +G+FPLRGKLLNVREA++ QIM N+EIQNIK+ILGL+ N  
Sbjct: 587  DSAKSMAVSGVGAIQGRDRFGIFPLRGKLLNVREANHDQIMKNQEIQNIKQILGLKHNHN 646

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y++  SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLLK+P+F+ EF TPI++    
Sbjct: 647  YTSTDSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPNFLNEFITPIVKVTKG 706

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
               ++ F++MPEYE W+E   NN  GW  KY K            YF D+ +HR  F   
Sbjct: 707  KQERM-FFTMPEYEEWKE-ANNNGHGWFAKYLK------------YFNDIQRHRLRFGTL 752

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNY-RDHVASRINYKDFVNKELILFSRADLQ 310
            +D D + I++AF+KKKA+DRK W+R F+PG + +      I   DFVNKELILFS AD  
Sbjct: 753  EDEDKTLIDLAFNKKKADDRKEWLRQFKPGTFLQTDDIDEIPISDFVNKELILFSMADNI 812

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPSV DGLKPGQRK++F  FKKK+  +IKV Q +GY+ E++AYHHGE SL STI+G+A
Sbjct: 813  RSIPSVADGLKPGQRKVIFGCFKKKIKNQIKVQQIVGYILENTAYHHGETSLYSTIVGLA 872

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q+F+GSNN+NLL P+GQFGTR  GGKD AS+RYI+T ++ ITR +FH  D+ +L  L E+
Sbjct: 873  QNFIGSNNVNLLAPHGQFGTRLQGGKDAASARYIHTSVSRITRTIFHPADEPILNNLFEE 932

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G  IEP +Y+P++PLVL+NG++GIGTGWS+ IPNYNP+D++ N+RR++  E   PM PW+
Sbjct: 933  GLHIEPEYYMPVVPLVLINGADGIGTGWSTSIPNYNPKDVVENIRRMMRGEEPEPMVPWF 992

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS--PNV 548
            RGFKG IE+  K+  + V+G  E+ID+++  ITELP+RKWTQD+K+ +E +T GS  P V
Sbjct: 993  RGFKGTIERLDKD-KFKVSGVAEKIDDKTIEITELPVRKWTQDFKEMIEQMTSGSDTPKV 1051

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
               +I+D+ +N  D  V   + MK E +     +G  K FKL+TT+STSNM  FD EGKI
Sbjct: 1052 VS-VIKDYEENHTDTTVHFRLHMKEEGMKKAEADGFDKFFKLSTTLSTSNMVCFDLEGKI 1110

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            +KY +PE+IL +F+P RL+YY  RKQY+ ++  +    L N+ RF+  ++  E+ VSN+K
Sbjct: 1111 RKYSSPEEILGDFYPKRLEYYALRKQYLADDLNKQFDRLSNQARFVQMIIKKELSVSNKK 1170

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            KA ++ EL+   F P PK G   +P  AG                           DY+Y
Sbjct: 1171 KAVIVQELRDHDFRPFPKGG--PKPVTAGESAPTLEEEEEEEDQGSD--------ADYDY 1220

Query: 729  LLSMSIGTLTLESVQ 743
            LL M+I  LT E V+
Sbjct: 1221 LLGMAIWNLTEEKVK 1235


>J5Q6D7_TRIAS (tr|J5Q6D7) DNA topoisomerase 2 OS=Trichosporon asahii var. asahii
            (strain ATCC 90039 / CBS 2479 / JCM 2466 / KCTC 7840 /
            NCYC 2677 / UAMH 7654) GN=A1Q1_05867 PE=3 SV=1
          Length = 1525

 Score =  762 bits (1967), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/735 (51%), Positives = 513/735 (69%), Gaps = 30/735 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA SGI++ +L++A FKQ + +KKTDG K  R+ GI KL+DAN AGGRN+ +CTLILTEG
Sbjct: 527  VAKSGIVENVLAFAKFKQDQAMKKTDGAKRSRIGGIAKLDDANWAGGRNASQCTLILTEG 586

Query: 73   DSAKALAMAGLSVV-GRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            DSAK++A++G+  + GRD +G+FPLRGKLLNVREA++ QIM N+EIQNIK+ILGL+ N  
Sbjct: 587  DSAKSMAVSGVGAIQGRDRFGIFPLRGKLLNVREANHDQIMKNQEIQNIKQILGLKHNHN 646

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y++  SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLLK+P+F+ EF TPI++    
Sbjct: 647  YTSTDSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPNFLNEFITPIVKVTKG 706

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
               ++ F++MPEYE W+E   NN  GW  KY K            YF D+ +HR  F   
Sbjct: 707  KQERM-FFTMPEYEEWKE-ANNNGHGWFAKYLK------------YFNDIQRHRLRFGTL 752

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNY-RDHVASRINYKDFVNKELILFSRADLQ 310
            +D D + I++AF+KKKA+DRK W+R F+PG + +      I   DFVNKELILFS AD  
Sbjct: 753  EDEDKTLIDLAFNKKKADDRKEWLRQFKPGTFLQTDDIDEIPISDFVNKELILFSMADNI 812

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPSV DGLKPGQRK++F  FKKK+  +IKV Q +GY+ E++AYHHGE SL STI+G+A
Sbjct: 813  RSIPSVADGLKPGQRKVIFGCFKKKIKNQIKVQQIVGYILENTAYHHGETSLYSTIVGLA 872

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q+F+GSNN+NLL P+GQFGTR  GGKD AS+RYI+T ++ ITR +FH  D+ +L  L E+
Sbjct: 873  QNFIGSNNVNLLAPHGQFGTRLQGGKDAASARYIHTSVSRITRTIFHPADEPILNNLFEE 932

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G  IEP +Y+P++PLVL+NG++GIGTGWS+ IPNYNP+D++ N+RR++  E   PM PW+
Sbjct: 933  GLHIEPEYYMPVVPLVLINGADGIGTGWSTSIPNYNPKDVVENIRRMMRGEEPEPMVPWF 992

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS--PNV 548
            RGFKG IE+  K+  + V+G  E+ID+++  ITELP+RKWTQD+K+ +E +T GS  P V
Sbjct: 993  RGFKGTIERLDKD-KFKVSGVAEKIDDKTIEITELPVRKWTQDFKEMIEQMTSGSDTPKV 1051

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
               +I+D+ +N  D  V   + MK E +     +G  K FKL+TT+STSNM  FD EGKI
Sbjct: 1052 VS-VIKDYEENHTDTTVHFRLHMKEEGMKKAEADGFDKFFKLSTTLSTSNMVCFDLEGKI 1110

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            +KY +PE+IL +F+P RL+YY  RKQY+ ++  +    L N+ RF+  ++  E+ VSN+K
Sbjct: 1111 RKYSSPEEILGDFYPKRLEYYALRKQYLADDLNKQFDRLSNQARFVQMIIKKELSVSNKK 1170

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            KA ++ EL+   F P PK G   +P  AG                           DY+Y
Sbjct: 1171 KAVIVQELRDHDFRPFPKGG--PKPVTAGESAPTLEEEEEEEDQGSD--------ADYDY 1220

Query: 729  LLSMSIGTLTLESVQ 743
            LL M+I  LT E V+
Sbjct: 1221 LLGMAIWNLTEEKVK 1235


>B8C9L4_THAPS (tr|B8C9L4) DNA topoisomerase 2 OS=Thalassiosira pseudonana
            GN=THAPSDRAFT_36420 PE=3 SV=1
          Length = 1230

 Score =  761 bits (1964), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 401/811 (49%), Positives = 528/811 (65%), Gaps = 38/811 (4%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V   G++D ++S+A FKQ++ LK+  GTK  +L GI KL+DAN+AG   S  CTLI+
Sbjct: 414  MKQVEKCGVVDAIMSYAKFKQNQALKRKGGTKKTKLTGITKLDDANNAGTAKSKDCTLII 473

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA++GLSVVGRD YGVFPL+GK LNVR+A++ QIM NEEI N+ +I+GL+  
Sbjct: 474  TEGDSAKSLAVSGLSVVGRDFYGVFPLKGKPLNVRDATHSQIMKNEEIMNLVEIMGLKFG 533

Query: 130  KEYS--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
              Y+  N+KSLRYGHLMIMADQDHDGSHIKGL+INFIH FWPSLL +P F+++F TPI++
Sbjct: 534  TTYTEENIKSLRYGHLMIMADQDHDGSHIKGLIINFIHHFWPSLLDIPDFLMQFITPIVK 593

Query: 188  AFHSNGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
               + G K  +F+++PEYE W+E  GN+A GW IKYYKGLGTST  E +EYF +L  H  
Sbjct: 594  C--TKGKKSHTFFTLPEYEEWKEGTGNDAKGWTIKYYKGLGTSTSSEAKEYFSNLDIHE- 650

Query: 247  DFVWEDDYDGSA---IEMAFSKKKAEDRKVWIRNFEPGNYRDHVASR---INYKDFVNKE 300
              + ++D   S    I+MAFSK K E+RK W+   E   + ++ A++   +NY +F+N+E
Sbjct: 651  --ILDNDAITSGAGLIDMAFSKSKVEERKKWLNRVEKDTFLNYSAAQRNGVNYSEFINRE 708

Query: 301  LILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQ 360
            L+LFS+ D  RSIP ++DG KP QRK+L+  FKKKL  EIKV Q  GY+ EHSAYHHG+ 
Sbjct: 709  LVLFSQYDNVRSIPHIMDGFKPSQRKVLYACFKKKLKAEIKVAQLAGYIGEHSAYHHGDM 768

Query: 361  SLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHEND 420
            SL  TIIGMAQ + GSNN+NLL P+GQFGTR +GGKDHAS+RYI+T L  I R +FH +D
Sbjct: 769  SLNGTIIGMAQSYCGSNNLNLLYPSGQFGTRRMGGKDHASARYIFTRLEKIARAIFHPDD 828

Query: 421  DKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLND 480
            D LL YLN+DG SIEP +Y+P+IP+VLVNGS+GIGTGWSS I N++PR++IAN+++++N 
Sbjct: 829  DALLNYLNDDGLSIEPEYYMPVIPMVLVNGSDGIGTGWSSTIQNHDPREVIANIKKMING 888

Query: 481  ETMVPMDPWYRGFKGII--EKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFL 538
            E    M P + G+ G I  E  ++EG YIV G +E   + +  ITELPI KWTQDYK FL
Sbjct: 889  EEPELMHPHFAGYTGEITAESGSREGSYIVEGKIERTGDTTLLITELPIGKWTQDYKGFL 948

Query: 539  ESI---TDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTT 593
            E +   TD SP+     I DF++N  D  V   +    + I    +E  GL+ KFKL+TT
Sbjct: 949  EGLMIGTDKSPSE----ISDFKENHTDTTVSFTVTASKDAIDKFEKEKGGLVGKFKLSTT 1004

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            IST NM LFD  GKI KY+    IL  FF  RL+YY +RK  +LE   R L V DNK RF
Sbjct: 1005 ISTKNMTLFDTNGKIHKYKASVDILRTFFHHRLEYYVKRKDMLLEKMRRELKVYDNKARF 1064

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXX 713
            +  V  G++VVSNRK+A+LL +LQ +G+   P++ K +E +                   
Sbjct: 1065 VEEVCKGDLVVSNRKRAELLADLQLRGYDLYPREVKKSETE-----------EEDDTSVE 1113

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXX 773
                     +G YEYLL M I +LT E  +                  T  +++WM    
Sbjct: 1114 EDASDAELAKG-YEYLLGMKIWSLTFERAEELRRQKAEKADEVEKLEGTSPEAIWMTDLE 1172

Query: 774  XXXXXXXXQDGKEAEDEKKRISQASKRTSTR 804
                    +D  E   E KR  QA  +   R
Sbjct: 1173 AIEEALDERD-VELNAELKREVQAQSKNKVR 1202


>M5E815_MALSM (tr|M5E815) Genomic scaffold, msy_sf_6 OS=Malassezia sympodialis ATCC
            42132 GN=MSY001_1414 PE=4 SV=1
          Length = 1333

 Score =  760 bits (1962), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 385/730 (52%), Positives = 501/730 (68%), Gaps = 12/730 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D + S A + Q + L+ +DG K  R+  + KLEDAN AG + S +CTLILTEG
Sbjct: 404  VLRSGVVDNVQSIAQYHQDRQLQASDGRKRSRV-SVTKLEDANWAGTKRSAECTLILTEG 462

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++G+S VGRD YGVFPLRGKLLNVREAS+ QIM N EI++IK+ILGLQ  K Y
Sbjct: 463  DSAKALAVSGISEVGRDAYGVFPLRGKLLNVREASHDQIMKNAEIKHIKEILGLQHGKVY 522

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V  LRYG LMIM DQD DGSHIKGL+INF+  F+PSLLK+P+F+VEF TPII+A    
Sbjct: 523  DSVDGLRYGSLMIMTDQDFDGSHIKGLIINFLDHFYPSLLKIPNFLVEFITPIIKATKGR 582

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K +F++MPEYE W+ N  +   GW +KYYKGLGTS P+E ++YF D+  H   F    
Sbjct: 583  EVK-AFFTMPEYEQWK-NSSDGGRGWTVKYYKGLGTSKPEEMKKYFHDMDTHLLAFETLR 640

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   +++AF+KKKA+DRK W+R F PG Y DH   +I   DF+NKELILFS AD  RS
Sbjct: 641  PGDRDLVDLAFNKKKADDRKEWLRQFVPGTYLDHRIRQIPISDFINKELILFSMADNIRS 700

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDGLKPGQRK+LF  FK+ L  EIKV Q  GYVSEH+AYHHG+QSL  TI+G+AQD
Sbjct: 701  IPSVVDGLKPGQRKVLFGCFKRNLKTEIKVQQLQGYVSEHTAYHHGDQSLVMTIVGLAQD 760

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            F GSNN+N+L PNGQFGTR++GGKD AS+RYI+T +  ITR LFH  DD LL YL+EDG+
Sbjct: 761  FCGSNNVNMLMPNGQFGTRSMGGKDAASARYIFTAVPRITRQLFHPKDDALLNYLDEDGQ 820

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY+P++P VL+NG++GIGTGWS+++PNYNPRDI+AN+RR +  E  VPM PWYRG
Sbjct: 821  SIEPEWYVPVVPQVLLNGADGIGTGWSTFVPNYNPRDIVANLRRRMVGEEYVPMIPWYRG 880

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G IE +A +  +   G   ++DE ++ ITELP+R WT  YK++LE    GS      L
Sbjct: 881  FAGTIEPTAPDR-FRCLGKATQLDEATWEITELPVRVWTSTYKEWLEERVVGSDKAAATL 939

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
             E +++   D  V   + +       + + G    FKL+T IST NM LF+ EGKIKKY 
Sbjct: 940  RE-YKEYHTDTTVHFIVELNARGQEEMERVGPESFFKLSTVISTGNMVLFNPEGKIKKYA 998

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             P  IL++F+ LRL +Y+RRK+++++  +R+   L N+ RF+  +++ E+ VSN+KKAD+
Sbjct: 999  TPLDILDDFYFLRLGFYQRRKEHMIDELKRVYDRLSNQARFVSMIIAKELSVSNKKKADI 1058

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL +  F   PK         A A                       +  DY+YLLSM
Sbjct: 1059 VQELGELQFQRFPKVA-------AKARSVAEVAEEEAEGETLDDADPTSRITDYDYLLSM 1111

Query: 733  SIGTLTLESV 742
            +I +LT E V
Sbjct: 1112 AIYSLTKERV 1121


>E5D8G5_9AGAR (tr|E5D8G5) DNA topoisomerase 2 OS=Omphalotus nidiformis GN=TopII
            PE=2 SV=1
          Length = 1557

 Score =  758 bits (1958), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 378/734 (51%), Positives = 507/734 (69%), Gaps = 12/734 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I++ +L+WA FK  + +KKTDG+K  RL G+ KL DAN+AG + +  CTLIL
Sbjct: 496  MKKVQKSPIVENILNWAKFKADQQIKKTDGSKRSRLTGLPKLADANNAGTKTARDCTLIL 555

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK+LA+AGL VVGR+++GVFPLRGKLL+VREA + QIM NEEIQNIKKI+GLQ N
Sbjct: 556  TEGDSAKSLAVAGLGVVGRNNFGVFPLRGKLLSVREARHDQIMKNEEIQNIKKIMGLQHN 615

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K+Y+NV SLRYG LMIM DQDHDGSHIKGLLINF+  F+PSLLKVP F+VEF TPIIR  
Sbjct: 616  KDYNNVSSLRYGRLMIMTDQDHDGSHIKGLLINFLDHFYPSLLKVPDFLVEFVTPIIRVT 675

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFV 249
              N  K  F+++PEYE W E     A  W  KY+KGLGTST  + R YF ++ KH   F 
Sbjct: 676  KGNQRK-DFFTIPEYEQWLETTPG-ADKWSTKYFKGLGTSTDADARGYFSNMAKHMIPFA 733

Query: 250  WEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADL 309
               + D   IE+AFSKKKA++RK W+R F+PG +  H    I Y +FVNKELILFS AD 
Sbjct: 734  PTQEGDRELIELAFSKKKADERKEWLRQFKPGTFLGHRLDEIPYSEFVNKELILFSMADN 793

Query: 310  QRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
             RSIPS+ DGLKP QRK+++  FK+ L KEIKV Q +GYVSEHS YHHG+ SL  TI+ +
Sbjct: 794  IRSIPSIADGLKPDQRKVIWSCFKRNLKKEIKVIQLVGYVSEHSVYHHGDASLTQTIVAL 853

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
            AQDFVGSNN+NLL P GQ+GTR++GGKDHAS+RYI T L PI+R +F+ +DD +L    +
Sbjct: 854  AQDFVGSNNLNLLVPCGQYGTRDMGGKDHASARYINTLLQPISRTIFNPDDDAILTPQTD 913

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            +   IEP +Y+PI+P+VL+NG+EGIGTGWS+ +P +NP DI+AN+RRL+N+E  VPM PW
Sbjct: 914  ENHVIEPEFYMPIVPMVLINGAEGIGTGWSTNVPGFNPLDIVANIRRLMNNEEQVPMHPW 973

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
            +RGFKG I+++AK   Y V G V ++D+ +  ITELPI KWTQ +K  LE++  G     
Sbjct: 974  WRGFKGEIKQTAK-NKYDVTGVVTKVDDTTVEITELPIHKWTQTFKTELETMLVGEKG-- 1030

Query: 550  DPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIK 609
            +  +++++++  +  V   ++M  +++    ++GLL+ FKLT+ I+TSNM  FD +GKIK
Sbjct: 1031 EGSVKNYQEHHANENVHFVVQMDAKELVKAEEKGLLEYFKLTSKITTSNMICFDFDGKIK 1090

Query: 610  KYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKK 669
            KYE+PE IL+EF+ +RL YY++RK ++    + +   L N+ RF+  +V  ++ VS RK+
Sbjct: 1091 KYESPEAILDEFYAVRLGYYQKRKDHLASQLQMVFERLSNQARFVQMIVEKKLAVSGRKR 1150

Query: 670  ADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYL 729
            AD++++L++  F            + A                            DY+YL
Sbjct: 1151 ADIVVDLKKHDFK-------PFPKKKAKTTSVGPEAEDEEEEDPDAGTEAEGSASDYDYL 1203

Query: 730  LSMSIGTLTLESVQ 743
            LSM I  LT E  +
Sbjct: 1204 LSMPIWNLTKEKFE 1217


>D7G0Y6_ECTSI (tr|D7G0Y6) DNA topoisomerase 2 OS=Ectocarpus siliculosus GN=TOP2
            PE=3 SV=1
          Length = 1809

 Score =  758 bits (1957), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 398/788 (50%), Positives = 508/788 (64%), Gaps = 45/788 (5%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
            S I+D +LSWA  KQ++ L K  G K+ +L GI KL+DAN AG   S  CTLILTEGDSA
Sbjct: 416  SEIVDRVLSWAKHKQNQQLNKKSGKKSSKLTGITKLDDANHAGTAKSQDCTLILTEGDSA 475

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNV 135
            K LA++GL VVGRD YGVFPL+GKLLNVREA+  Q++ NEEIQN+ KILGL+ N  Y + 
Sbjct: 476  KTLAVSGLGVVGRDRYGVFPLKGKLLNVREATGPQVLKNEEIQNVVKILGLKFNHTYDDT 535

Query: 136  KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNG-T 194
            K LRYGHLMIM DQDHDGSHIKGLLINF+H +WPSLLK+  F+ EF TPI++   S G  
Sbjct: 536  KQLRYGHLMIMTDQDHDGSHIKGLLINFVHHYWPSLLKIDGFLQEFITPIVKV--SKGRN 593

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
            +LSFY++PEY  W+E   N   GW  KYYKGLGTST +E +EYF  L  H+ +F W+DD 
Sbjct: 594  ELSFYTVPEYTVWKEGHAN-GKGWNAKYYKGLGTSTAKEAKEYFAALDTHQLEFEWQDDD 652

Query: 255  DGSAIE-MAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
                +  MAFSKK+ EDRK W+R F+ G + D+    + Y+ F+NKELILFS  D +RSI
Sbjct: 653  RDDDLIDMAFSKKRVEDRKEWLRGFKAGTHADYNVESVTYESFINKELILFSMEDNKRSI 712

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            P +VDG KP QRK+LF  FK+ L KEIKV Q  GYVSEHSAYHHGE SL  TI  MAQ+F
Sbjct: 713  PCLVDGFKPSQRKVLFSCFKRNLKKEIKVVQLAGYVSEHSAYHHGETSLNGTITAMAQNF 772

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
             GSNN+NLL P GQFGTR +GGKD AS RYI+T L    R +FH +DD LL YL++DG S
Sbjct: 773  TGSNNLNLLTPGGQFGTRLMGGKDAASPRYIFTALQKAARAVFHPDDDALLTYLDDDGLS 832

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP +Y+PIIPL+LVNGS+GIGTGWSS +PNY+P D+I N++R +  +  V M PWY+GF
Sbjct: 833  IEPEFYMPIIPLILVNGSDGIGTGWSSNVPNYSPHDVIENLKRRIKGDKFVEMQPWYKGF 892

Query: 494  KGIIE----KSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVK 549
             G IE    K   EG Y V G    ID+ +  ITELP+RKWTQDYKQFLES+  G+ + K
Sbjct: 893  AGSIEAKVGKKGFEGSYTVRGIANRIDDTTVEITELPVRKWTQDYKQFLESLLPGAEDAK 952

Query: 550  DP------------------------LIEDFRQNGDDAMVDIEIRMKLEKI-AMIMQEGL 584
                                       I+DF++N  D  V   + M +E + A+   +GL
Sbjct: 953  SKDAKGNGKGKGKGKGAADKDKSPTRCIKDFKENHTDTTVHFTVTMSMEDLDALEKGDGL 1012

Query: 585  LKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLL 644
             K FKL +++ST+NM LFD +G +++YE+P+ I+EEF  LR ++Y RRK  +L   +   
Sbjct: 1013 YKFFKLESSVSTNNMVLFDQDGHLERYESPQHIMEEFITLRSEFYGRRKTSLLSKLQSEW 1072

Query: 645  LVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKG---FTPMPKKGKSAEPQVAGAXXX 701
              LDNKVRFIL VV   + V+NRKK++LL +L+++G   F P      +++ +VAG    
Sbjct: 1073 SKLDNKVRFILAVVEDRMQVNNRKKSELLEQLKREGYDLFLPT-----TSKLRVAGGAED 1127

Query: 702  XXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXA 761
                                    Y+YLL M I +LTLE V+                 A
Sbjct: 1128 GEGEDGNEESAADDSDTLSK---GYDYLLGMKIWSLTLERVKLLENELEGKAEEMRILKA 1184

Query: 762  TPSKSMWM 769
            T    +W+
Sbjct: 1185 TAPSELWL 1192


>A8PTE9_MALGO (tr|A8PTE9) DNA topoisomerase 2 OS=Malassezia globosa (strain ATCC
            MYA-4612 / CBS 7966) GN=MGL_0413 PE=3 SV=1
          Length = 1376

 Score =  757 bits (1955), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 378/731 (51%), Positives = 503/731 (68%), Gaps = 16/731 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SG++D + S   + Q + L+ TDG K  R+  + KLEDAN AG + S +CTLILTEG
Sbjct: 376  VLKSGVIDNVQSIVQYHQDRQLQATDGRKRSRV-SVTKLEDANWAGTKRSAECTLILTEG 434

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LA++GLS VGRD YGVFPLRGKLLNVREA+  QI  N EI+NIK+ILGLQ  K Y
Sbjct: 435  DSAKGLAVSGLSEVGRDAYGVFPLRGKLLNVREATYDQIKKNTEIKNIKEILGLQHGKSY 494

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            S V  LRYG LMIM DQD DGSHIKGL+IN++  F+PSLLK+P+F+VEF TPII+A    
Sbjct: 495  STVDGLRYGSLMIMTDQDFDGSHIKGLIINYLDHFYPSLLKIPNFLVEFITPIIKATKGQ 554

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              + SF+++PE+E W+   G+   GW  KYYKGLGTS P E +EYFRD+ +H   F    
Sbjct: 555  EVR-SFFTIPEFEQWKAT-GDGGRGWTTKYYKGLGTSKPYEMKEYFRDMDRHMLSFDTIR 612

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   +++AF+KKKA+DRK W+R F PG Y DH    I   DF+NKELILFS AD  RS
Sbjct: 613  PEDHDLLDLAFNKKKADDRKEWLRQFVPGTYLDHRIRNIPISDFINKELILFSMADNIRS 672

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSVVDGLKPGQRK++F  FK+KL  EIKV Q  GYVSEHSAYHHG+Q+L  TI+G+AQD
Sbjct: 673  IPSVVDGLKPGQRKVIFSCFKRKLKTEIKVHQLQGYVSEHSAYHHGDQALTMTIVGLAQD 732

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            F GSNN+NLL PNGQFG+R++GGKD AS+RYI+T +  ITR +FH +D+ LL YL +DG+
Sbjct: 733  FCGSNNVNLLMPNGQFGSRSMGGKDAASARYIFTAVPRITRLMFHADDEPLLNYLEDDGQ 792

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP WY P++P VL+NG+EGIGTGWS+++PNYNPR+++ N+RR +  E  VPM+PWYRG
Sbjct: 793  SIEPEWYAPVVPQVLLNGAEGIGTGWSTFVPNYNPREVVDNLRRRMAGEEYVPMNPWYRG 852

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G IE +  E  + V G   ++DE+++ ITELP+R WT  YK++LE    GS +    +
Sbjct: 853  FVGGIEPAGPE-RFRVTGIARQLDERTWEITELPVRVWTMTYKEWLEERVVGS-DKTPAV 910

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            + ++++   D  V   + +    +  I + G    FKL+T +STSNM LF+ EGKIKKY 
Sbjct: 911  LREYKEYHTDTSVHFVVELNPRGMEEIERVGPDTFFKLSTMLSTSNMVLFNPEGKIKKYA 970

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             P++ILE+F+ +RL +Y+RRK+++++  + +   L N+ RF+  +++ E+ VSN+KKA +
Sbjct: 971  TPQEILEDFYFVRLGFYQRRKEHLVDQLKLVYDRLSNQARFVSMIIARELSVSNKKKAAI 1030

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL+Q  F   PK    A+     A                          DY+YLLSM
Sbjct: 1031 VEELRQLKFQAFPKVEAKAKSVTEEAVEDQEEPDEPANSNT-----------DYDYLLSM 1079

Query: 733  SIGTLTLESVQ 743
            +I +LT E V+
Sbjct: 1080 AIYSLTQERVE 1090


>R9AGH6_WALIC (tr|R9AGH6) DNA topoisomerase 2 OS=Wallemia ichthyophaga EXF-994
            GN=J056_004105 PE=4 SV=1
          Length = 1422

 Score =  756 bits (1952), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 373/732 (50%), Positives = 495/732 (67%), Gaps = 14/732 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V+ SGI++++L WA F   + L K D    +    I   E+AN AGGR   KCTLILTEG
Sbjct: 459  VSKSGIVESILDWAKFDADRQLAKGDTKTKKSKISIKDYEEANKAGGREGHKCTLILTEG 518

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
             SAK LAM+G  VVGRD+YGVFPLRGKLLNVR+AS+  IM+N E+  IK I+GL   KEY
Sbjct: 519  LSAKTLAMSGSQVVGRDYYGVFPLRGKLLNVRDASHSSIMNNAELTAIKSIIGLAHKKEY 578

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            S++  LRYG +MIM DQDHDGSHIKGLLIN+  +F+PSLLK+P+F+VEF TPII+ F  N
Sbjct: 579  SSITELRYGSIMIMTDQDHDGSHIKGLLINYFDTFYPSLLKIPNFLVEFITPIIKVFKRN 638

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              ++SF+++PE+E+W+    ++  GW++KYYKGLGTS+ +E R+YF+ L +HR  F    
Sbjct: 639  -QEVSFFTVPEFENWKAQ-NDDGRGWRLKYYKGLGTSSDEEARQYFKALERHRIPFTSTQ 696

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D D   I+MAF+KK+ EDRK W+R + PG Y DH    I YKDFVNKELILFS AD  RS
Sbjct: 697  DGDRELIDMAFNKKRTEDRKEWLRGYTPGTYLDHDIDEITYKDFVNKELILFSMADNARS 756

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDG KPGQRK+L+ + K+ L  EIKV Q    V+E+++YHHGEQSL  TI+GMAQ 
Sbjct: 757  IPSMVDGFKPGQRKVLYGTIKRNLKSEIKVAQLGMSVAENTSYHHGEQSLIQTIVGMAQS 816

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNN+N+L PNGQFG+R  GGKD A++RYI+T +  ITR +FH NDD +L YL ED  
Sbjct: 817  YVGSNNLNILSPNGQFGSRREGGKDSAAARYIFTAIPRITRTVFHPNDDPILTYLKEDDE 876

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP WY+PIIP+VLVNG++GIGTGWS+ IPNYNP D++AN+RR LN++ M PM PWYRG
Sbjct: 877  WIEPEWYVPIIPMVLVNGADGIGTGWSTTIPNYNPADLVANIRRKLNNQEMQPMIPWYRG 936

Query: 493  FKGIIEKSAKEGGYIVN-GTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            F G IE+         N G +E ID+   RITELP+R WT  YK+    +         P
Sbjct: 937  FTGNIEQMPNTTDRFKNQGIIEHIDDFKVRITELPVRVWTVPYKEEKLKLWAQGNEKTAP 996

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            LI+D+ ++     V+  + +  +++   +++GL + FKL  +I+TSN+  F +EGKI+KY
Sbjct: 997  LIKDYEEHDTTTTVEFIVTLDQKQMKTALEKGLHEYFKLNGSIATSNIVCFTSEGKIRKY 1056

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
             NPE+ILEEFF +RL YY+ RK Y +         L N+ RFI  +V  E++VSNRK+ D
Sbjct: 1057 ANPEEILEEFFYIRLKYYQLRKDYQMHELGVAFDRLSNQARFIKMIVERELIVSNRKRKD 1116

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ EL+ K FTP PK+ +   P                               D++YLLS
Sbjct: 1117 VVAELRAKKFTPFPKQREKKRPGEVEIIGQEEEEEENEGGA-----------SDFDYLLS 1165

Query: 732  MSIGTLTLESVQ 743
            M I +LT+E ++
Sbjct: 1166 MQISSLTMERME 1177


>D0N9W9_PHYIT (tr|D0N9W9) DNA topoisomerase 2 OS=Phytophthora infestans (strain
           T30-4) GN=PITG_07823 PE=4 SV=1
          Length = 807

 Score =  754 bits (1946), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 375/662 (56%), Positives = 473/662 (71%), Gaps = 26/662 (3%)

Query: 41  KTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKL 100
           K  RL GI KL+DAN AG   S  CTLILTEGDSAK +A+ GL+VVGRD+YGVFPLRGK+
Sbjct: 120 KRSRLTGIPKLDDANHAGTAKSKDCTLILTEGDSAKTVAVGGLAVVGRDYYGVFPLRGKM 179

Query: 101 LNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLL 160
           LNVREAS+ QI+ NEEIQN+ KILGL+  ++Y + K LRYGHLMIMADQDHDGSHIKGL+
Sbjct: 180 LNVREASHSQILKNEEIQNVVKILGLKYGQKYESTKGLRYGHLMIMADQDHDGSHIKGLV 239

Query: 161 INFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKI 220
           IN IH FWPSLL V  F+ EF TPI++      TK  FY+MPEYE+WRE   N   GW I
Sbjct: 240 INLIHHFWPSLLVVDGFLQEFITPIVKCTKGR-TKEVFYTMPEYEAWRERT-NQGRGWII 297

Query: 221 KYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEP 280
           K+YKGLGTST  E +EY  DL  H+  F ++ D D   I+MAFSKK+ EDRK W+R +EP
Sbjct: 298 KFYKGLGTSTDAETKEYLSDLQTHQIRFTYDGDGDADVIDMAFSKKRVEDRKDWLRGYEP 357

Query: 281 GNYRDHVASRINYKD------FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKK 334
           G Y D+    + Y +      FVNKELILFS AD  RSIPSV    KP QRK+LFC FK+
Sbjct: 358 GTYVDYDVDEMGYPEYAYRAGFVNKELILFSMADNIRSIPSVR--FKPSQRKVLFCCFKR 415

Query: 335 KLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLG 394
            L  E+KV Q  GYVSEHSAYHHGE SL   I+ MAQDFVGSNNI+LL P GQFG+R +G
Sbjct: 416 NLRAELKVAQLAGYVSEHSAYHHGEASLQGCIVNMAQDFVGSNNIHLLPPIGQFGSRLMG 475

Query: 395 GKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGI 454
           GKD AS+RYI+T L  +TR ++H  D+  L+YL+EDG+SIEP WYIPIIP+VLVNGS+GI
Sbjct: 476 GKDAASARYIFTNLEQLTRLIYHPLDNDCLKYLSEDGQSIEPEWYIPIIPMVLVNGSDGI 535

Query: 455 GTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKG-IIEKS----AKEGGYIVN 509
           GTGWS   PNYNP DII  +R+++N E + P+ PWYR F G I+EK+       G YIV 
Sbjct: 536 GTGWS---PNYNPLDIIKGLRQMINGEEIAPLTPWYREFTGHIVEKANSRGTDTGNYIVQ 592

Query: 510 GTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEI 569
           G  E  D+ +  ++ELP++ WTQ YKQFLE + D         I+DF++N  D  V   I
Sbjct: 593 GLYEVTDDSTLVVSELPVKSWTQTYKQFLEGLLDAGT------IKDFKENHTDVKVLFTI 646

Query: 570 RMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLD 627
            M+ + ++ + +   G++KKFKL +++STSNMHLFDA G IKKYENP++I+ EF+ +RL+
Sbjct: 647 TMEQKALSDVTKAPGGIVKKFKLESSLSTSNMHLFDAAGHIKKYENPKEIMAEFYGIRLE 706

Query: 628 YYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKK 687
           YY RRK+ +L+  +  + +L NK RF+L VV G++VV+NRKK +LL EL  +G+  +  K
Sbjct: 707 YYGRRKKAMLQKLQDQIKLLSNKARFVLAVVEGKLVVNNRKKQELLEELMAEGYDQIVPK 766

Query: 688 GK 689
            K
Sbjct: 767 TK 768


>E0S6I5_ENCIT (tr|E0S6I5) DNA topoisomerase 2 OS=Encephalitozoon intestinalis
            (strain ATCC 50506) GN=Eint_040290 PE=3 SV=1
          Length = 1141

 Score =  753 bits (1944), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 388/758 (51%), Positives = 505/758 (66%), Gaps = 63/758 (8%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             + N+ ++  + S+A  +QS+ LKKTDG KT RL GI KLEDAN AG   S  CTLILTE
Sbjct: 369  VIKNTSLVQKVTSFAKARQSQQLKKTDGAKTSRLSGIPKLEDANFAGTSKSKDCTLILTE 428

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK LA++GLSVVGRD YGVFPLRGKLLNVREAS+KQIMDN EI NIKKILGLQ NK 
Sbjct: 429  GDSAKTLAVSGLSVVGRDIYGVFPLRGKLLNVREASHKQIMDNAEISNIKKILGLQHNKI 488

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y +V SLRYGH+MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+ EF TPI+RA   
Sbjct: 489  YEDVSSLRYGHIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIVRA-SK 547

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
             G    F+++PEYE +++N    + GW IKYYKGLGTST  + ++YF +L  H K F   
Sbjct: 548  KGEVKDFFTLPEYEEFKKN----SDGWNIKYYKGLGTSTSADAKQYFSNLPIHVKYFTPL 603

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             + D   I++AF+KKKA+ RK W+ NFEPG + D    +I+  DFVNKELILFS AD  R
Sbjct: 604  IEEDKELIDLAFNKKKADARKTWLLNFEPGTFLDQSQPQISISDFVNKELILFSMADNIR 663

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRK++F  FK+ L  EIKV Q +GYVSE SAYHHGEQSL STI+ +AQ
Sbjct: 664  SIPSLVDGLKPGQRKVMFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQ 723

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL P GQFG+R  GGKD AS RYI+T L+P+TR +F+ENDD +L YLN+D 
Sbjct: 724  DFVGSNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRLIFNENDDAILSYLNDDN 783

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
             SIEP +Y+PIIP+VLVNG+EGIGTGWS+ IPN+NP D++ N+RRL+  E  V M P+YR
Sbjct: 784  LSIEPEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRLIRGEDPVEMIPYYR 843

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
             F+G IEK   EG Y V+G  E   +    I+ELP+  WT +YK+FLES+      V+  
Sbjct: 844  NFRGTIEKVG-EGKYQVSGIYE--GDMDLEISELPVGTWTLNYKEFLESL------VQAG 894

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            +++DF++   +  V   +++             +   KL+TTI+ +NM  FD    IKKY
Sbjct: 895  VVKDFKEYHTEKTVSFSVKLSKS----------ISNLKLSTTITINNMVCFDENLGIKKY 944

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
              P++IL+EF+ +RL YY  RK+ +L+  +  L+ L+NKVRFI  V +GE+V+S R+K +
Sbjct: 945  STPQEILKEFYDVRLRYYSIRKENMLKVMKEELVKLENKVRFIKEVSTGELVISRRRKGE 1004

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ +L+ + +                                        +  DYEYLLS
Sbjct: 1005 VIFDLESRRYA---------------------------------------RVDDYEYLLS 1025

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            MSI +LT+E ++                 +   K +W+
Sbjct: 1026 MSILSLTVERIEKLNNEHAKKLEEYNKLESKTPKELWL 1063


>D2UZM0_NAEGR (tr|D2UZM0) DNA topoisomerase 2 OS=Naegleria gruberi
            GN=NAEGRDRAFT_29557 PE=3 SV=1
          Length = 1457

 Score =  753 bits (1944), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/753 (51%), Positives = 506/753 (67%), Gaps = 20/753 (2%)

Query: 20   DTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALA 79
            + +L +ADFK  K L K  GTK  RL GI KL+DANDAG +NS+KCTLILTEGDSAKALA
Sbjct: 422  EAVLKYADFKSEKALNKKSGTKKSRLTGISKLDDANDAGSKNSEKCTLILTEGDSAKALA 481

Query: 80   MAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYS--NVKS 137
            + GLSVVGRD+YGVFPL+GK LNVR+    +++ NEEI  + KILGL+ +K Y+  ++KS
Sbjct: 482  VGGLSVVGRDYYGVFPLKGKPLNVRDCKLDKVVKNEEISTLAKILGLKFDKTYTKEDIKS 541

Query: 138  LRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK-L 196
            LRYG +MIMADQDHDGSHIKGLLINFIH FWPSLLK+P F+ EF TPI++A ++   K +
Sbjct: 542  LRYGSIMIMADQDHDGSHIKGLLINFIHKFWPSLLKIPGFLKEFITPIVKATNNRTKKAV 601

Query: 197  SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDG 256
            +F+S+PEYE+W+E L ++  GW IKYYKGLGTST  E +EYF ++  H+K F ++ D D 
Sbjct: 602  TFFSIPEYETWKEGL-SDTKGWTIKYYKGLGTSTAPEAKEYFSNMSLHQKRFKYDTDCD- 659

Query: 257  SAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSV 316
              I   FSK   ++RK W+ N + G Y DH    I+Y DF++KELILFS+AD +RSIPS+
Sbjct: 660  KKITSVFSKAATDERKEWLNNHQEGTYIDHSKKEISYTDFIDKELILFSKADCKRSIPSI 719

Query: 317  VDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGS 376
            VDGLKPGQRKILF  FK+ L KEIKV Q  GYVSE SAYHHGE SL  T++ MAQ+FVGS
Sbjct: 720  VDGLKPGQRKILFSCFKRNLKKEIKVAQLAGYVSEQSAYHHGEDSLNGTVVNMAQNFVGS 779

Query: 377  NNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEP 436
            NNINLL P G FGTR  GGKD AS RYI+T+L+ ITR +F + DD +LEYL++DG+SIEP
Sbjct: 780  NNINLLYPGGMFGTRLQGGKDSASPRYIFTKLSEITRYIFPKADDPVLEYLDDDGQSIEP 839

Query: 437  SWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGI 496
             +Y+PI+P+VLVNGSEGIGT WS+ I  YNP DI+  ++ L+  E      PWY+GF GI
Sbjct: 840  RFYVPILPMVLVNGSEGIGTAWSTNIETYNPVDIVEGLKALIKGEEAKEFHPWYKGFDGI 899

Query: 497  IEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIEDF 556
            IE+ A    +   G +E+ID+ +  I+ELPIR WT+ +K+ LE + +         ++DF
Sbjct: 900  IERLA-PTKWQTKGVIEKIDDNTLDISELPIRIWTESFKERLEKMMEAQQ------VDDF 952

Query: 557  RQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQ 616
            R+N  D  V   ++M  +++      GL   FKL    STSNM LF  EG IK+YE    
Sbjct: 953  RENHTDVTVSFTVKMTDKQMKDAEDAGLYDYFKLFKKFSTSNMVLFSEEGGIKEYETVLD 1012

Query: 617  ILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMEL 676
            IL+EF+P+RL +Y +RK+Y+LE  ++ L +L NKVRFI+ V++  I V  RKKADLL EL
Sbjct: 1013 ILKEFYPIRLKFYGKRKEYMLEKMKKELEILSNKVRFIMEVINETIQVKKRKKADLLKEL 1072

Query: 677  QQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGT 736
            + K ++  PK     E ++A A                           Y YLLSM + +
Sbjct: 1073 KTKKYSSFPK-----EKKIAAAGDIQNEEEEEEEDEEKDVADLT---DGYNYLLSMPLWS 1124

Query: 737  LTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            LT+E V+                  T  ++MW+
Sbjct: 1125 LTVEKVKKLEKEKEEKVKEVEQLENTKPETMWL 1157


>F8PB32_SERL9 (tr|F8PB32) DNA topoisomerase 2 OS=Serpula lacrymans var. lacrymans
            (strain S7.9) GN=SERLADRAFT_453445 PE=3 SV=1
          Length = 1467

 Score =  751 bits (1940), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/735 (51%), Positives = 501/735 (68%), Gaps = 38/735 (5%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  S I+D +L+WA FK  + +KKTDG+K  RL G+ KL DAN+AG RN++KCTLIL
Sbjct: 474  MKKVQKSTIIDNILNWAKFKADQQIKKTDGSKRNRLTGLPKLADANNAGTRNAEKCTLIL 533

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TE                 D++GVFPLRGKLLNVREA + QIM NEEIQNIKKI+GLQ N
Sbjct: 534  TE-----------------DNFGVFPLRGKLLNVREAKHDQIMKNEEIQNIKKIMGLQHN 576

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K YS + SLRYG LMIM DQDHDGSHIKGLLINF+  F+PSLLK+P+F+VEF TPI+R  
Sbjct: 577  KVYSGIGSLRYGRLMIMTDQDHDGSHIKGLLINFLDHFFPSLLKIPNFLVEFVTPIVRV- 635

Query: 190  HSNG-TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
             S G  ++ F+++PEYE W E+  + A  W  KY+KGLGTS+  + R YF ++ KH   F
Sbjct: 636  -SKGKQRIDFFTIPEYEQWVEDTPD-AHKWDAKYFKGLGTSSDSDARLYFSNMAKHMIPF 693

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D D   IE+AFSKKKA++RK W+R F+ G Y DH    I+Y DF+N+ELILFS AD
Sbjct: 694  AATQDGDKELIELAFSKKKADERKEWLRQFKAGTYLDHNIDEISYSDFINRELILFSMAD 753

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIP++ DGLKPGQRK+++  FK+KL KEIKV Q +GY+SE +AYHHGE SL  TI+ 
Sbjct: 754  NIRSIPALADGLKPGQRKVIWGCFKRKLKKEIKVAQLVGYISEVAAYHHGEASLTMTIVN 813

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQD+VGSNN+NLL PNGQ+GTR+ GGKDHAS+RYI+TEL+P+ R +++  DD LL YL 
Sbjct: 814  LAQDYVGSNNVNLLLPNGQYGTRDQGGKDHASARYIFTELSPLARTIYNPADDPLLTYLK 873

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            ED   IEP +Y+P+IPLVL+NG+EGIGTGWS+ IP YNP DI+ N+RR++  E +VPM P
Sbjct: 874  EDNDWIEPEYYLPVIPLVLINGAEGIGTGWSTSIPCYNPEDIVNNIRRMMAGEELVPMLP 933

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG I+K   +  Y V G   +I++ +  ITELPI KWTQ+YK  LE++       
Sbjct: 934  WWRGFKGTIKKVG-DYKYDVIGVARKINDTTVEITELPIHKWTQNYKAELEAMIGEK--- 989

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKI 608
             + +I+D++++ D+  +   I M  + +    ++GL + FKLT+ I+TSNM  F+ +GKI
Sbjct: 990  GEGIIKDYKEHHDNVNIHFVITMSPKDLEKAEEQGLTEFFKLTSKINTSNMICFNLDGKI 1049

Query: 609  KKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRK 668
            +KY+ PE+I+EEFFP RL  Y+ RK Y+    +     L N+ RF+  +V  E++V+NRK
Sbjct: 1050 QKYQTPEEIIEEFFPKRLACYQSRKDYLANELQTQFERLSNQARFVKMIVDKELIVANRK 1109

Query: 669  KADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            KAD++ EL++  F P PK  K+     A                            DY+Y
Sbjct: 1110 KADIISELRKLKFRPFPKVVKAKAAGEAEDAEEEEDETSNTST-------------DYDY 1156

Query: 729  LLSMSIGTLTLESVQ 743
            LL M+I +LT E ++
Sbjct: 1157 LLGMAIWSLTSEKIE 1171


>G4TR37_PIRID (tr|G4TR37) DNA topoisomerase 2 OS=Piriformospora indica (strain DSM
            11827) GN=PIIN_07734 PE=3 SV=1
          Length = 1521

 Score =  750 bits (1937), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 382/742 (51%), Positives = 484/742 (65%), Gaps = 42/742 (5%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + I+D++L+WA +K  + +KKTDGTK  RL G+ KL DAN+AG RN   CTLILTEG
Sbjct: 517  VGKTSIIDSILNWAKYKADQQIKKTDGTKRSRLNGMTKLCDANNAGSRNGSACTLILTEG 576

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA+AGLSVVGRD++GVFPLRGKLLNVREAS+ QIM NEEIQNIKKI+GLQ NK+Y
Sbjct: 577  DSAKALAVAGLSVVGRDNFGVFPLRGKLLNVREASHDQIMKNEEIQNIKKIMGLQHNKDY 636

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             + +SLRYG LMIMADQDHDGSHIKGLLINF   F+PSLLK+P F+VEF TPI+R  H  
Sbjct: 637  KSTESLRYGRLMIMADQDHDGSHIKGLLINFFDHFYPSLLKLPEFLVEFVTPIVRVKHGK 696

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              K +F+++PEY+ W E   +  +GW  KYYKGLGTS  Q+ + YF D+  H   F    
Sbjct: 697  TYK-NFFTIPEYQQWAEAHAH-ISGWTAKYYKGLGTSEDQDAKAYFSDMPTHMIPFSKLR 754

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            + D   I+MAFSKKK E+RK W+RNF PG Y +H    I Y +F+NKELILFS AD  RS
Sbjct: 755  EEDRQLIDMAFSKKKVEERKEWLRNFVPGTYLNHNRDEIPYSEFINKELILFSMADNARS 814

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKP QRK++F  FK+KL  EIKV Q +GY+ EH+A+HHG+ SL  TI+ +AQ 
Sbjct: 815  IPSMVDGLKPSQRKVVFACFKRKLKGEIKVNQLMGYIGEHTAHHHGDASLHQTIVNLAQH 874

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL P GQFGTR  GGKDHA++RYI T    + R +F+ +DD LL YL ED  
Sbjct: 875  FVGSNNINLLYPAGQFGTRAAGGKDHAAARYISTRPVDLARKIFNTSDDALLNYLTEDNL 934

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP WY+P +PLVL+NG++GIGTGWS+ IPNYNP DI                      
Sbjct: 935  KIEPEWYMPTVPLVLINGADGIGTGWSTSIPNYNPVDI---------------------- 972

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV---- 548
              G IEK+  +G Y   G    ID ++  I+ELPIRKWT DYK+ LE    G+       
Sbjct: 973  --GTIEKADNKGKYTCTGIARVIDSKTVEISELPIRKWTDDYKKQLEDWVIGAEKDKSDK 1030

Query: 549  -------KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHL 601
                    +  I+D+R+      V   + M  + +A   +EGL K FKLT +ISTSNM  
Sbjct: 1031 DKEKGKPSETFIKDYREYHTTTSVSFVVTMSEKDVARAEKEGLEKFFKLTASISTSNMIC 1090

Query: 602  FDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGE 661
            FD+ GKI KYE PE ILE+F+ LRL +Y +RKQ++    E  L  L+N+ RF+  +V  +
Sbjct: 1091 FDSAGKIHKYETPEDILEDFYHLRLQWYAKRKQHVSNEMELELDRLNNQARFVQMIVDKK 1150

Query: 662  IVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXX 721
            +VV+NRKK D++ EL++  FTP PK      P+                           
Sbjct: 1151 LVVANRKKEDIVKELRELQFTPFPK-----SPKTKKQDDTEAVVENDIDEDDVAVIKGLP 1205

Query: 722  KRGDYEYLLSMSIGTLTLESVQ 743
               D++YLL M+I  LT E ++
Sbjct: 1206 SNSDFDYLLGMAIWNLTREKIE 1227


>Q8SS63_ENCCU (tr|Q8SS63) DNA topoisomerase 2 OS=Encephalitozoon cuniculi (strain
            GB-M1) GN=ECU04_0350 PE=3 SV=1
          Length = 1144

 Score =  748 bits (1932), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 398/806 (49%), Positives = 515/806 (63%), Gaps = 75/806 (9%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            + N+ I+  + S+A  KQS+ LKKTDG KT RL GI KLEDAN AG   S  CTLILTEG
Sbjct: 370  IKNTPIVQKITSFAKAKQSQQLKKTDGAKTSRLSGIPKLEDANFAGTSRSKDCTLILTEG 429

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LA+AGLSVVGRD YGVFPLRGKLLNVREAS+KQIM+N EI +IKKILGLQ NK Y
Sbjct: 430  DSAKTLAVAGLSVVGRDAYGVFPLRGKLLNVREASHKQIMENAEISSIKKILGLQHNKVY 489

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYGH+MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+ EF TPIIRA    
Sbjct: 490  EDVSSLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRA-TKK 548

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G    F+++PEYE +++N      GW IKYYKGLGTST  + ++YF +L  H K F    
Sbjct: 549  GQVRDFFTLPEYEEFKKN----EDGWNIKYYKGLGTSTSADAKQYFSNLPVHVKSFTPLA 604

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I++AF+KKKA+ RK W+ NF PG + D   ++I+  DFVNKELILFS AD  RS
Sbjct: 605  AEDKELIDLAFNKKKADARKTWLLNFAPGTFLDQSQTQISISDFVNKELILFSMADNIRS 664

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRK++F  FK+ L  EIKV Q +GYVSE SAYHHGEQSL STI+ +AQD
Sbjct: 665  IPSLVDGLKPGQRKVIFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQD 724

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL P GQFG+R  GGKD AS RYI+T L+P+TR +F+ENDD +L YLN+D  
Sbjct: 725  FVGSNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRMIFNENDDAILNYLNDDNF 784

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP +Y+PIIP+VLVNG+EGIGTGWS+ IPN+NP D++ N+RR++  E  V M P+YR 
Sbjct: 785  SIEPEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRMIRGEDPVEMVPYYRN 844

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F+G IEK   EG + V+G  E   +    ITELP+  WT +YK+FLES+      V+  +
Sbjct: 845  FRGTIEKIG-EGKFQVSGIYE--GDMDLEITELPVGTWTLNYKEFLESL------VQAGV 895

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
              DF++   +  V   +++             +   KL +TI+ +NM  FD   +IKKY 
Sbjct: 896  ARDFKEYHTEKTVSFTVKLSKP----------VSNLKLNSTITVNNMVCFDENLRIKKYA 945

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             P++IL+EF+ +RL YY  RK+ +L+     L  L+NKVRFI  V  GE+V+S R+K ++
Sbjct: 946  TPQEILKEFYGVRLRYYLIRKENMLKVMREELEKLENKVRFIKEVSMGELVISRRRKGEV 1005

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L+ +G+                                        +  DYEYLLSM
Sbjct: 1006 IFDLESRGYA---------------------------------------RADDYEYLLSM 1026

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
            SI +LT+E ++                     K +W+            +D +  E E  
Sbjct: 1027 SILSLTVERIERLSNEHAKRLSEYNQLMGKTPKELWL------------EDLEVFEKEYL 1074

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPR 818
            RI++   R    +L     KK  +P+
Sbjct: 1075 RIAENEAREYDDELNGCIKKKGKRPK 1100


>M1KJ03_ENCCN (tr|M1KJ03) DNA topoisomerase 2 OS=Encephalitozoon cuniculi
            GN=ECU04_0350 PE=3 SV=1
          Length = 1144

 Score =  748 bits (1931), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 398/806 (49%), Positives = 515/806 (63%), Gaps = 75/806 (9%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            + N+ I+  + S+A  KQS+ LKKTDG KT RL GI KLEDAN AG   S  CTLILTEG
Sbjct: 370  IKNTPIVQKITSFAKAKQSQQLKKTDGAKTSRLSGIPKLEDANFAGTSRSKDCTLILTEG 429

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LA+AGLSVVGRD YGVFPLRGKLLNVREAS+KQIM+N EI +IKKILGLQ NK Y
Sbjct: 430  DSAKTLAVAGLSVVGRDAYGVFPLRGKLLNVREASHKQIMENAEISSIKKILGLQHNKVY 489

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYGH+MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+ EF TPIIRA    
Sbjct: 490  EDVSSLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRA-TKK 548

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
            G    F+++PEYE +++N      GW IKYYKGLGTST  + ++YF +L  H K F    
Sbjct: 549  GQVRDFFTLPEYEEFKKN----EDGWNIKYYKGLGTSTSADAKQYFSNLPVHVKSFTPLA 604

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I++AF+KKKA+ RK W+ NF PG + D   ++I+  DFVNKELILFS AD  RS
Sbjct: 605  AEDKELIDLAFNKKKADARKTWLLNFAPGTFLDQSQTQISISDFVNKELILFSMADNIRS 664

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPS+VDGLKPGQRK++F  FK+ L  EIKV Q +GYVSE SAYHHGEQSL STI+ +AQD
Sbjct: 665  IPSLVDGLKPGQRKVIFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQD 724

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL P GQFG+R  GGKD AS RYI+T L+P+TR +F+ENDD +L YLN+D  
Sbjct: 725  FVGSNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRMIFNENDDAILNYLNDDNF 784

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP +Y+PIIP+VLVNG+EGIGTGWS+ IPN+NP D++ N+RR++  E  V M P+YR 
Sbjct: 785  SIEPEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRMIRGEDPVEMVPYYRN 844

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F+G IEK   EG + V+G  E   +    ITELP+  WT +YK+FLES+      V+  +
Sbjct: 845  FRGTIEKIG-EGKFQVSGIYE--GDMDLEITELPVGTWTLNYKEFLESL------VQAGV 895

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
              DF++   +  V   +++             +   KL +TI+ +NM  FD   +IKKY 
Sbjct: 896  ARDFKEYHTEKTVSFTVKLSKP----------VSNLKLNSTITVNNMVCFDENLRIKKYA 945

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
             P++IL+EF+ +RL YY  RK+ +L+     L  L+NKVRFI  V  GE+V+S R+K ++
Sbjct: 946  TPQEILKEFYGVRLRYYLIRKENMLKVMREELEKLENKVRFIKEVSMGELVISRRRKGEV 1005

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L+ +G+                                        +  DYEYLLSM
Sbjct: 1006 IFDLESRGYA---------------------------------------RADDYEYLLSM 1026

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
            SI +LT+E ++                     K +W+            +D +  E E  
Sbjct: 1027 SILSLTVERIERLSNEHAKRLSEYNQLMGKTPKELWL------------EDLEVFEKEYL 1074

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPR 818
            RI++   R    +L     KK  +P+
Sbjct: 1075 RIAENEAREYDDELNGCIKKKGKRPK 1100


>Q7RJ69_PLAYO (tr|Q7RJ69) DNA topoisomerase 2 OS=Plasmodium yoelii yoelii
            GN=PY03394 PE=3 SV=1
          Length = 1489

 Score =  748 bits (1931), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 383/767 (49%), Positives = 514/767 (67%), Gaps = 26/767 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTLI 68
            V  S IL  +L WA  K   +L+K          +R+ GI KLEDANDAG + S +CTLI
Sbjct: 443  VLKSSILSNILLWAQAKAQVELRKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLI 502

Query: 69   LTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ- 127
            LTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI KI+GL  
Sbjct: 503  LTEGDSAKTSCLAGLSIVGRDRYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFKIMGLDI 562

Query: 128  QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             +K   ++K LRYG LMIM DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI++
Sbjct: 563  TDKNKQDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLCEFVTPIVK 622

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                N  +LSF+++ EYE W+EN   N  GWKIKYYKGLGTST +E ++YF D+  H+  
Sbjct: 623  VQKGN-QELSFFTIAEYEQWKEN--TNLVGWKIKYYKGLGTSTDKEFKQYFSDIQSHKIF 679

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR 
Sbjct: 680  FLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRY 739

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TII
Sbjct: 740  DTERSIPNIMDGWKPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTII 799

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
             MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR +F+E DD +L+YL
Sbjct: 800  NMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYL 859

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
            NE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N+++ ++ E +VPM 
Sbjct: 860  NEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIINNIKKYIDKEPLVPMV 919

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWY+ FKG IE + K  GY   G + +ID+++  ITELPI++WTQDYK+FLE +     +
Sbjct: 920  PWYKDFKGRIEPNGK-SGYETIGIINKIDDETLEITELPIKRWTQDYKEFLEELL---TD 975

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
             K+ LI D+  N     V   I+M   K+    +EGL K FKL +T++T+NM LFD + K
Sbjct: 976  EKNQLIIDYIDNSSHEDVCFTIKMDPIKLKRAEEEGLEKVFKLKSTLTTTNMTLFDPKLK 1035

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            +++Y +   IL++F   RL+ Y  RK Y++   E+   ++ NK +FIL +++GE+VV+ +
Sbjct: 1036 LQRYASELDILKDFCFHRLNAYTDRKNYLISKLEKEKRIISNKTKFILAIINGELVVNKK 1095

Query: 668  KKADLLMELQQKGFTPMP-----KKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXK 722
            KK  L+ EL +KG+ P       KK +  E ++  A                        
Sbjct: 1096 KKKILVEELYRKGYDPYKDIHKLKKEEIFEQELLDAAENPEDNEEIIAGVTVK------- 1148

Query: 723  RGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
              DY YLL+M I +LTLE V+                 +   ++MW+
Sbjct: 1149 --DYNYLLNMPIFSLTLEKVEELLSQLKEKEQELEILKSITVETMWL 1193


>G7I3Z5_MEDTR (tr|G7I3Z5) DNA topoisomerase 2 OS=Medicago truncatula
            GN=MTR_1g075370 PE=3 SV=1
          Length = 1176

 Score =  748 bits (1930), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 420/739 (56%), Positives = 502/739 (67%), Gaps = 49/739 (6%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  S ILD LL    FK    +                  DA  AG  +S KCTLILT+G
Sbjct: 327  VQKSQILDNLLPRIPFKHRTHV------------------DAKLAGRPDSGKCTLILTQG 368

Query: 73   DSAKALAMAGLS-VVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
               K LAM+GLS VV  D YGVFPL  KLLN    S K +   +EIQN+  ILGL +NK+
Sbjct: 369  QYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQNLMAILGLVRNKK 427

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            YSN K LRYG LM+MA+QD DG+H KGLLINF +SFWPSLLKV  FM  FT PII+A  S
Sbjct: 428  YSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFPIIKASDS 487

Query: 192  N-GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
              G +LSF SM +YE W++ LGN A  W+IKY +GL  S+ QE REYF+DLGKHR  FVW
Sbjct: 488  KKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYFQDLGKHRAYFVW 545

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPG--NYRDHVASRINYKDFVNKELILFSRAD 308
             DD D ++I++AFSKK AE+ + WI N +PG  NY   V   INY++FVNKEL+  S  +
Sbjct: 546  -DDKDETSIKLAFSKK-AEEWEAWIGNSQPGTCNYERKV---INYRNFVNKELLFSSMKN 600

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
            LQRSIPSVVDGL  GQRK LFCSF+  L K+ +V +   YV+EHS  H+G+QS+ASTIIG
Sbjct: 601  LQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIG 660

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            MAQDFVGSNNINLL P GQFGTR+LGGKDHASSR +Y +LN +TR LF  +DDKLLEYLN
Sbjct: 661  MAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLN 720

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            EDGRSI+P+WYIPIIPLVLVNG   +GT +SS IP Y+P +II NVRR LN+E MV M P
Sbjct: 721  EDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKP 780

Query: 489  WYRGFKGIIEKSAKE-GGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            WY+GF G IEKSAK  G Y V+G VE I+EQ+FRI ELPIR WT+DYK+FLE IT     
Sbjct: 781  WYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITARG-- 838

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQ-EGLLKKFKLTTTISTSNMHLFDAEG 606
                LIE FRQ GD  +V+ ++ +K E+IA I + E L KKF LT TISTSNM+LFDAEG
Sbjct: 839  ----LIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEG 894

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            KIKKY  PEQILEEF  LRL YY RRKQY+++NF +LL  L  K +FI  +V+ +    N
Sbjct: 895  KIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPIN 954

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXX--XXXXXXXXXXXXXKRG 724
            R +A+LL+E+         KKGKSAEP VAGA                           G
Sbjct: 955  R-RAELLIEIL--------KKGKSAEPHVAGAIDYSSKEQEAGEQESVSQSVSIEGATLG 1005

Query: 725  DYEYLLSMSIGTLTLESVQ 743
            DYEYL S+     TLES++
Sbjct: 1006 DYEYLSSLPFENFTLESLK 1024


>I6UKY3_ENCHA (tr|I6UKY3) DNA topoisomerase 2 OS=Encephalitozoon hellem (strain
            ATCC 50504) GN=EHEL_040280 PE=3 SV=1
          Length = 1144

 Score =  748 bits (1930), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 388/758 (51%), Positives = 502/758 (66%), Gaps = 63/758 (8%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             + N+ I+  + S+A  +QS  LKKTDG KT RL GI KLEDAN AG   S  CTLILTE
Sbjct: 369  VIKNTSIVQRVASFARARQSLQLKKTDGAKTSRLSGIPKLEDANFAGTSRSKDCTLILTE 428

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK LA++GLSVVGRD YGVFPLRGKLLNVREAS+KQIM+N EI +IKKILGLQ NK 
Sbjct: 429  GDSAKTLAVSGLSVVGRDIYGVFPLRGKLLNVREASHKQIMENSEISSIKKILGLQHNKV 488

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y +  SLRYGH+MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+ EF TPIIRA   
Sbjct: 489  YEDTSSLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRA-TK 547

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
             G    F+++PEYE ++++      GW IKYYKGLGTST  + ++YF +L  H K+F   
Sbjct: 548  KGQVRDFFTLPEYEEFKKS----EEGWNIKYYKGLGTSTSADAKQYFSNLPIHVKNFTPL 603

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             D D   I++AF+KKKA+ RK W+ +FEPG + D    +I+  DFVNKELILFS AD  R
Sbjct: 604  VDEDKELIDLAFNKKKADARKTWLLSFEPGTFLDQSLPQISISDFVNKELILFSMADNIR 663

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRK++F  FK+ L  EIKV Q +GYVSE SAYHHGEQSL STI+ +AQ
Sbjct: 664  SIPSLVDGLKPGQRKVMFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQ 723

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL P GQFG+R  GGKD AS RYI+T L+P+TR +F+ENDD +L YLN+D 
Sbjct: 724  DFVGSNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRLIFNENDDAILNYLNDDN 783

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
             SIEP +Y+PIIP+VLVNG+EGIGTGWS+ IPN+NP DII N+RR++ DE  V M P+YR
Sbjct: 784  LSIEPEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPIDIIENIRRMIRDEDPVEMTPYYR 843

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
             F+G IEK   EG + V+G  E   +    ITELP+  WT +YK+FLES+      V+  
Sbjct: 844  NFRGTIEKVG-EGKFQVSGVYE--GDMDLEITELPVGTWTLNYKEFLESL------VQAG 894

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            +++DF++   +  V+  +++             +   KL TTI+ +NM  FD +  IKKY
Sbjct: 895  VVKDFKEYHTEKTVNFTVKLAKH----------VSNLKLNTTITINNMVCFDEKLGIKKY 944

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
              P+ IL+EF+ +RL YY  RK+ +L+  +  L+ L+NKVRFI  V +G +V+S R++A+
Sbjct: 945  STPKDILKEFYDVRLRYYSIRKENMLKVMKEELVRLENKVRFIKEVSTGGLVISRRRRAE 1004

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ +L+ +G+                                        K  DYEYLL 
Sbjct: 1005 IVFDLEARGYA---------------------------------------KADDYEYLLG 1025

Query: 732  MSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            MSI +LT E ++                     K +W+
Sbjct: 1026 MSILSLTAERIEKLSNEHSKKLEEYNRLAGKTPKKLWL 1063


>I3ESC1_NEMP1 (tr|I3ESC1) DNA topoisomerase 2 OS=Nematocida parisii (strain ERTm1 /
            ATCC PRA-289) GN=NEPG_00303 PE=3 SV=1
          Length = 1182

 Score =  741 bits (1914), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/820 (47%), Positives = 519/820 (63%), Gaps = 53/820 (6%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  SGI++     A  KQ++ LKKTDG KT +LRGI KL+DAN+AG R + +CTLILTEG
Sbjct: 372  IMKSGIVEKSAYAARAKQTQQLKKTDGHKTSKLRGIPKLDDANNAGTRYAAQCTLILTEG 431

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA++GLSV+GRD+YGVFPLRGKLLNVREA++KQ+M+N EI NIKKI+GLQ  KEY
Sbjct: 432  DSAKSLAVSGLSVIGRDNYGVFPLRGKLLNVREATHKQLMENMEINNIKKIMGLQHGKEY 491

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +  +SLRYGHLMIM DQDHDGSHIKGL+IN +  F+PSLLK+  F+ EF TPI+RA   +
Sbjct: 492  ATTESLRYGHLMIMTDQDHDGSHIKGLIINMLDHFFPSLLKIKGFLQEFITPIVRATKGS 551

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             ++  F+++PE+ESW E       GWKIKYYKGLGTST ++ ++YF +L  H K+F+  D
Sbjct: 552  MSR-DFFTIPEFESWCETSEGRENGWKIKYYKGLGTSTAKDAKDYFSNLDFHIKEFIPMD 610

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   IE+AFSKK+ E RKVW++ F PG Y D+    I+ K+F+++ELI FS AD  RS
Sbjct: 611  STDRDKIELAFSKKRIESRKVWLKEFVPGTYLDNRVQAISIKNFIDRELIHFSLADNIRS 670

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP+V+DG+KPGQRKI++C FK++L  EIKV Q  GYVSEHSAYHHGEQSL STI+ +AQD
Sbjct: 671  IPNVIDGMKPGQRKIIYCCFKRQLKSEIKVAQLAGYVSEHSAYHHGEQSLCSTIVNLAQD 730

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNNI LL+P GQFGTR  GGKD AS RYI+T L  ITR +F E DD LL YL +D  
Sbjct: 731  YVGSNNIPLLQPIGQFGTRLQGGKDAASPRYIFTALQQITRYIFREQDDHLLNYLKDDNL 790

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             +EP  YIPIIP+VLVNGSEGIGTGWS+ IP+YNP +I+ NV+R++N      M PWY+G
Sbjct: 791  MVEPDMYIPIIPMVLVNGSEGIGTGWSTCIPSYNPIEIVDNVKRMINGHEPEDMMPWYKG 850

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G  E     G Y   GT  E++     I ELPI  WTQ+YK FLE++ +         
Sbjct: 851  FAGECEDLGG-GKYRTTGTF-ELETGKINILELPIGTWTQNYKDFLETLIESGD------ 902

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+DFR+   D  V  E+ +  +K+       + K FKL++ IST+NM  F+++G ++KY 
Sbjct: 903  IKDFREYNTDTKVYFEVIVSKQKV------NVPKVFKLSSQISTANMVAFNSKGVLQKYT 956

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +P +IL+EF+P+R D Y RRK ++L+     + +L+NKVRFI  VV+  + +  RK AD+
Sbjct: 957  SPSEILKEFYPVRRDLYVRRKDFLLKKLNVEMTILENKVRFIKEVVADTLKIVKRKSADI 1016

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL  K +T                                       K   Y+YLL+M
Sbjct: 1017 VKELTDKEYT--------------------------------------KKDNSYDYLLTM 1038

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
            SI +LT+E +                      + MW+                +     K
Sbjct: 1039 SIASLTVERIDKLENESSTKRKEYNTLKNISIEDMWISDLDEFLKHLDLSVKNDDNPRPK 1098

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNS 832
            R  +  K+           +KPP+ +K      ++ESD S
Sbjct: 1099 RKGRKIKQPVISKEIKNNPQKPPKNKKEKVSVLDSESDFS 1138


>I3EH32_NEMP3 (tr|I3EH32) DNA topoisomerase 2 OS=Nematocida parisii (strain ERTm3)
            GN=NEQG_01219 PE=3 SV=1
          Length = 1182

 Score =  741 bits (1914), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/820 (47%), Positives = 519/820 (63%), Gaps = 53/820 (6%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  SGI++     A  KQ++ LKKTDG KT +LRGI KL+DAN+AG R + +CTLILTEG
Sbjct: 372  IMKSGIVEKSAYAARAKQTQQLKKTDGHKTSKLRGIPKLDDANNAGTRYAAQCTLILTEG 431

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA++GLSV+GRD+YGVFPLRGKLLNVREA++KQ+M+N EI NIKKI+GLQ  KEY
Sbjct: 432  DSAKSLAVSGLSVIGRDNYGVFPLRGKLLNVREATHKQLMENMEINNIKKIMGLQHGKEY 491

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +  +SLRYGHLMIM DQDHDGSHIKGL+IN +  F+PSLLK+  F+ EF TPI+RA   +
Sbjct: 492  ATTESLRYGHLMIMTDQDHDGSHIKGLIINMLDHFFPSLLKIKGFLQEFITPIVRATKGS 551

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             ++  F+++PE+ESW E       GWKIKYYKGLGTST ++ ++YF +L  H K+F+  D
Sbjct: 552  MSR-DFFTIPEFESWCETSEGRENGWKIKYYKGLGTSTAKDAKDYFSNLDFHIKEFIPMD 610

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   IE+AFSKK+ E RKVW++ F PG Y D+    I+ K+F+++ELI FS AD  RS
Sbjct: 611  STDRDKIELAFSKKRIESRKVWLKEFVPGTYLDNRVQAISIKNFIDRELIHFSLADNIRS 670

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP+V+DG+KPGQRKI++C FK++L  EIKV Q  GYVSEHSAYHHGEQSL STI+ +AQD
Sbjct: 671  IPNVIDGMKPGQRKIIYCCFKRQLKSEIKVAQLAGYVSEHSAYHHGEQSLCSTIVNLAQD 730

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNNI LL+P GQFGTR  GGKD AS RYI+T L  ITR +F E DD LL YL +D  
Sbjct: 731  YVGSNNIPLLQPIGQFGTRLQGGKDAASPRYIFTALQQITRYIFREQDDHLLNYLKDDNL 790

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             +EP  YIPIIP+VLVNGSEGIGTGWS+ IP+YNP +I+ NV+R++N      M PWY+G
Sbjct: 791  MVEPDMYIPIIPMVLVNGSEGIGTGWSTCIPSYNPIEIVDNVKRMINGHEPEDMMPWYKG 850

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G  E     G Y   GT  E++     I ELPI  WTQ+YK FLE++ +         
Sbjct: 851  FAGECEDLGG-GKYRTTGTF-ELETGKINILELPIGTWTQNYKDFLETLIESGD------ 902

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+DFR+   D  V  E+ +  +K+       + K FKL++ IST+NM  F+++G ++KY 
Sbjct: 903  IKDFREYNTDTKVYFEVIVSKQKV------NVPKVFKLSSQISTANMVAFNSKGVLQKYT 956

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +P +IL+EF+P+R D Y RRK ++L+     + +L+NKVRFI  VV+  + +  RK AD+
Sbjct: 957  SPSEILKEFYPVRRDLYVRRKDFLLKKLNVEMTILENKVRFIKEVVADTLKIVKRKSADI 1016

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL  K +T                                       K   Y+YLL+M
Sbjct: 1017 VKELTDKEYT--------------------------------------KKDNSYDYLLTM 1038

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKK 792
            SI +LT+E +                      + MW+                +     K
Sbjct: 1039 SIASLTVERIDKLENESSTKRKEYNTLKNISIEDMWISDLDEFLKHLDLSVKNDDNPRPK 1098

Query: 793  RISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNS 832
            R  +  K+           +KPP+ +K      ++ESD S
Sbjct: 1099 RKGRKIKQPVISKEIKNNPQKPPKNKKEKVSVLDSESDFS 1138


>H6BPZ5_EXODN (tr|H6BPZ5) DNA topoisomerase 2 OS=Exophiala dermatitidis (strain
            ATCC 34100 / CBS 525.76 / NIH/UT8656) GN=HMPREF1120_01903
            PE=3 SV=1
          Length = 1661

 Score =  740 bits (1910), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/685 (53%), Positives = 483/685 (70%), Gaps = 17/685 (2%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  VA + +++ +L +A  K  + LKK+DG++  R+    KL DAN AG R   KCTLIL
Sbjct: 506  MKKVAKTEVINNILHFAQQKADQILKKSDGSRRSRMNN-PKLTDANKAGTREGHKCTLIL 564

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK LA+AG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  LGLQ  
Sbjct: 565  TEGDSAKGLALAGRAVVGPDLFGVFPLRGKLLNVRDASIDQISKNAEIQNIKNFLGLQHK 624

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            K Y++   LRYGHLMIM DQDHDGSHIKGLLINF+   +PSLLK+P F+VEF TPI++ +
Sbjct: 625  KVYTDTHGLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPKFLVEFITPIVKVY 684

Query: 190  HSN----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHR 245
              +        +FY+MPEYE+W+E    +  GW+ KYYKGLGTST ++ ++YF D+ KH 
Sbjct: 685  RGDPKNPSQSRAFYTMPEYEAWKE-AHKHERGWEHKYYKGLGTSTSEDAQQYFNDIDKHH 743

Query: 246  KDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFS 305
            K+F    D + S IE+AFSKKKA++RK W+R F+ G Y DH A  I+Y DFVNKELILFS
Sbjct: 744  KEFDVMKDEEASLIELAFSKKKADERKEWLRQFKAGTYLDHSAKIISYSDFVNKELILFS 803

Query: 306  RADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLAST 365
             AD  RSIPSVVDGLKPGQRK+++  FK+ L K++KV +  G VS  +AYHHGE SL  T
Sbjct: 804  MADNVRSIPSVVDGLKPGQRKVMYACFKRNLKKDMKVAELAGLVSGMTAYHHGEASLQQT 863

Query: 366  IIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLE 425
            I+G+AQDFVGSNN+NLL+P+GQFGTRN GG D AS+RYI+T L+P  R LFH +D+ LL+
Sbjct: 864  IVGLAQDFVGSNNVNLLEPSGQFGTRNQGGNDCASARYIHTRLSPFARKLFHTDDEALLK 923

Query: 426  YLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVP 485
            Y  +D R+IEP  Y PIIP+VLVNG++GIGTGWSSYIPNYNP DI+ N++R +N E   P
Sbjct: 924  YNTDDERTIEPEVYAPIIPMVLVNGADGIGTGWSSYIPNYNPEDIVENLKRRMNGEDWKP 983

Query: 486  MDPWYRGFKGIIEKSAKEGG---YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT 542
            M PWYRGFKG +    K GG   ++ +G +++  +    ITELPIR WTQD+K  LE I 
Sbjct: 984  MQPWYRGFKGEV----KAGGPDRFLFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEII 1039

Query: 543  DGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHL 601
                  K P  I+D++       V   I++  + +   ++EGL++KFKLT +I+TSN+  
Sbjct: 1040 KAE---KVPSFIKDYKDYNTHETVHFVIQLDEKHMKSAVEEGLVEKFKLTKSIATSNLVA 1096

Query: 602  FDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGE 661
            FD EG+I KY N E I++EF+  RL  Y +RK+++LE+  + L  L N+ RF+  ++ G+
Sbjct: 1097 FDPEGRITKYANVEAIMDEFYRYRLQMYAKRKEWLLEDMNKTLRRLTNQARFVQMIIDGK 1156

Query: 662  IVVSNRKKADLLMELQQKGFTPMPK 686
            + +S +KKA L+ EL++ GF   PK
Sbjct: 1157 LNISKKKKAVLVAELKKLGFDAYPK 1181


>I4YK24_WALSC (tr|I4YK24) DNA topoisomerase 2 OS=Wallemia sebi (strain ATCC
            MYA-4683 / CBS 633.66) GN=WALSEDRAFT_14295 PE=3 SV=1
          Length = 1322

 Score =  740 bits (1910), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/735 (49%), Positives = 502/735 (68%), Gaps = 22/735 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVK-LEDANDAGGRNSDKCTLILTE 71
            V+ SGI+D +L WA F   + + K D TKT++ +  +K  E+AN AG R   KCTLILTE
Sbjct: 417  VSKSGIVDNILDWAKFDADRQMAKGD-TKTKKSKVSIKDYEEANKAGSREGHKCTLILTE 475

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            G SAK LAM+G  VVGRD+YGVFPLRGKLLNVR+AS+  IM+N EI +IK I+GL   KE
Sbjct: 476  GLSAKTLAMSGSQVVGRDYYGVFPLRGKLLNVRDASHTSIMNNAEITSIKTIIGLAHKKE 535

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y ++  LRYG +MIM DQDHDGSHIKGLLIN+   F+PSLLK+P F+VEF TPII+ F  
Sbjct: 536  YKSITELRYGSIMIMTDQDHDGSHIKGLLINYFDHFYPSLLKIPGFLVEFITPIIKLFKR 595

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
            N  ++SF+++PE+E W+    +   GW++KYYKGLGTS+ +E R+YF+ L +HR  F   
Sbjct: 596  N-KEVSFFTIPEFEHWKAE-NDEGRGWRLKYYKGLGTSSDEEARQYFKALDRHRIPFSAT 653

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             + D   I+MAF+KK+ EDRK W+R + P  + D     ++YKDF+NKELILFS AD  R
Sbjct: 654  QEGDRELIDMAFNKKRTEDRKEWLRGYNPRTFLDQDIEELSYKDFINKELILFSMADNAR 713

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDG KPGQRKIL+ + K+ L  EIKV Q    V+E++AYHHGE  L  TI+GMAQ
Sbjct: 714  SIPSMVDGFKPGQRKILYGTIKRNLKNEIKVAQLGMSVAENTAYHHGETILFQTIVGMAQ 773

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            +FVGSNN+N+L PNGQFG+R  GGKD A++RYI+T +  ITR +FH +DD +L YL ED 
Sbjct: 774  NFVGSNNLNILSPNGQFGSRREGGKDAAAARYIFTAIPRITRTIFHPDDDPILTYLKEDD 833

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
              IEP WY+PIIP+VLVNG++GIGTGWS+ IPNYNP D++AN+RR LN++ + PM PWYR
Sbjct: 834  EWIEPEWYVPIIPMVLVNGADGIGTGWSTTIPNYNPSDLVANIRRKLNNQDIQPMIPWYR 893

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
            GF G IE+ + +  +   G +E+ID+   RITELP+R WT  YK+    +     + + P
Sbjct: 894  GFTGNIERVSNDR-FKNQGIIEQIDDDKVRITELPVRVWTVPYKEEKLKLWVQGSDKQQP 952

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            LI+D+ ++     V+  + ++  ++   + +GL + FKL ++I+TSN+  F+++GKIKKY
Sbjct: 953  LIKDYEEHDTTTTVEFIVTLEKNQMKTALSKGLHEYFKLNSSIATSNIVCFNSDGKIKKY 1012

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
              PE+ILEEFF +RL YY+ RK Y +         + N+ RFI  ++  E+++SNRK+ D
Sbjct: 1013 TAPEEILEEFFYIRLKYYQLRKDYQMHELGIAFDRISNQARFIKMIIDRELIISNRKRKD 1072

Query: 672  LLMELQQKGFTPMPK---KGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEY 728
            ++ EL+ K FTP PK   K +  E ++ G                          GDY+Y
Sbjct: 1073 IVDELRAKKFTPYPKQKEKKRPGEVEIIGQDEEEEENVGGA--------------GDYDY 1118

Query: 729  LLSMSIGTLTLESVQ 743
            LLSM I +LT+E ++
Sbjct: 1119 LLSMQISSLTMERME 1133


>D0NA12_PHYIT (tr|D0NA12) DNA topoisomerase 2 OS=Phytophthora infestans (strain
            T30-4) GN=PITG_07874 PE=3 SV=1
          Length = 1505

 Score =  739 bits (1909), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 379/736 (51%), Positives = 483/736 (65%), Gaps = 62/736 (8%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGT--KTQRLRGIVKLEDANDAGGRNSDKCTLILTEGD 73
            SG+++ +LS+A FKQ+ +L++  G+  K  RL GI KL+DAN AG   S  CTLILTEGD
Sbjct: 499  SGLVEKILSFAAFKQTAELRRKGGSSGKRSRLTGIPKLDDANHAGTAKSKDCTLILTEGD 558

Query: 74   SAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYS 133
            SAK                                  I+ NEEIQN+ KILGL+  ++Y 
Sbjct: 559  SAKT---------------------------------ILKNEEIQNVVKILGLKYGQKYE 585

Query: 134  NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNG 193
            + K LRYGHLMIMADQDHDGSHIKGL+IN IH FWPSLL V  F+ EF TPI++      
Sbjct: 586  STKGLRYGHLMIMADQDHDGSHIKGLVINLIHHFWPSLLVVDGFLQEFITPIVKCTKGR- 644

Query: 194  TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDD 253
            TK  FY+MPEYE+WRE   N   GW IKYYKGLGTST  E +EYF DL  H+  F ++ D
Sbjct: 645  TKEVFYTMPEYEAWRERT-NQGRGWVIKYYKGLGTSTAAETKEYFSDLQTHQIGFTYDGD 703

Query: 254  YDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
             D   I+MAFSKK+ EDRK W+R +EPG Y D+    + Y +FVNKELILFS AD  RSI
Sbjct: 704  GDADVIDMAFSKKRVEDRKDWLRGYEPGTYVDYDVDEMGYTEFVNKELILFSMADNIRSI 763

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            PSV+DG KP QRK+LFC FK+ L  E+KV Q  GYVSEHSAYHHGE SL   I+ MAQDF
Sbjct: 764  PSVMDGFKPSQRKVLFCCFKRNLRAELKVAQLAGYVSEHSAYHHGEASLQGCIVNMAQDF 823

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
            VGSNNI+LL P GQFGTR +GGKD AS+RYI+T L  +TR ++H  D+  L+YL+EDG+S
Sbjct: 824  VGSNNIHLLSPIGQFGTRLMGGKDAASARYIFTNLEQLTRLIYHPLDNDCLKYLSEDGQS 883

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP WYIPIIP+VLVNGS+GIGTGWSS +PNYNP DII  +R+++N E + P+ PWYRGF
Sbjct: 884  IEPEWYIPIIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEIAPLTPWYRGF 943

Query: 494  KG-IIEKS----AKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
             G I+EK+       G YIV G  E  D+ +  ++ELP++ WTQ YKQFLE + D     
Sbjct: 944  TGHIVEKANSRGTDTGNYIVQGLYEVTDDSTLVVSELPVKSWTQTYKQFLEGLLDAG--- 1000

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFDAEG 606
                I+DF++N  D  V   I M+ + ++ + +   G++KKFKL +++STSNMHLFDA G
Sbjct: 1001 ---TIKDFKENHTDVKVLFTITMEPKALSDVTKAPGGIVKKFKLESSLSTSNMHLFDAAG 1057

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
             IKKYENP++I+ EF+ +RL+YY RRK+ +L+  +  + +L NK RF+L VV G++VV+N
Sbjct: 1058 HIKKYENPKEIMAEFYGIRLEYYGRRKKAMLQKLQDQIKLLSNKARFVLAVVEGKLVVNN 1117

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            RKK +LL EL  +G+            Q+                           RG Y
Sbjct: 1118 RKKQELLEELMAEGYD-----------QIVSKTKKKPDNEDSNESEDEEPNVADVSRG-Y 1165

Query: 727  EYLLSMSIGTLTLESV 742
            +YLLSM I +LT E V
Sbjct: 1166 DYLLSMKIWSLTKERV 1181


>K6UXA3_9APIC (tr|K6UXA3) DNA topoisomerase 2 OS=Plasmodium cynomolgi strain B
            GN=PCYB_132540 PE=3 SV=1
          Length = 1506

 Score =  738 bits (1905), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 390/799 (48%), Positives = 517/799 (64%), Gaps = 18/799 (2%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTL 67
            +V  S IL  +L WA  K   +L+K          +R+ GI KLEDANDAG + S +CTL
Sbjct: 451  SVLKSPILSNILLWAQAKAQVELRKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTL 510

Query: 68   ILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ 127
            ILTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI KI+GL 
Sbjct: 511  ILTEGDSAKTSCLAGLSIVGRDRYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFKIMGLD 570

Query: 128  -QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPII 186
              +K   ++K LRYG LMIM DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI+
Sbjct: 571  ITDKNKEDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIV 630

Query: 187  RAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
            +    N  + SF+++ EYE W+E+   N  GWKIKYYKGLGTST +E +EYF D+  H+ 
Sbjct: 631  KVQKGN-QEYSFFTIAEYEQWKES--TNLVGWKIKYYKGLGTSTDKEFKEYFSDIKNHKI 687

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
             F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR
Sbjct: 688  MFLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFIIGSYVDHKEKDLSYYDFVNKELIYYSR 747

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
             D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TI
Sbjct: 748  YDTERSIPNIMDGWKPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTI 807

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            I MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR LF+E DD +L+Y
Sbjct: 808  INMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSLFNEYDDPILKY 867

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            LNE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N++R +N E ++PM
Sbjct: 868  LNEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIENIKRYINKEELIPM 927

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PWY+ FKG IE + K  GY   G + +ID+++  I ELPI+KWTQDYK+FLE +     
Sbjct: 928  IPWYKDFKGRIESNGK-TGYETIGIIHKIDDETLEINELPIKKWTQDYKEFLEELL---T 983

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
            + K  LI D+  N     +   I+M   K+    +EGL K FKL +T++T+NM LFD   
Sbjct: 984  DEKSQLIVDYIDNSSHEDICFTIKMDPAKLKKAEEEGLEKVFKLKSTLTTTNMTLFDPNL 1043

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            K+++Y     IL+EF   RL  YE RK Y++   E+   ++ NK +FIL +V+ E++VS 
Sbjct: 1044 KLQRYSTELDILKEFCFHRLKAYENRKNYLISKLEKEKKIISNKSKFILAIVNDELIVSK 1103

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KK  L+ EL +KG+ P     K  + ++                             DY
Sbjct: 1104 KKKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLESAENPEDNEEIIAGISVK----DY 1159

Query: 727  EYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKE 786
            +YLLSM I +LTLE V+                     ++MW+            Q   E
Sbjct: 1160 DYLLSMPIFSLTLEKVEELLAQLKEKERELEILKNITVETMWLKDIEKVEEAIEFQRNVE 1219

Query: 787  A--EDEKKRISQASKRTST 803
                +E  R   A K+T++
Sbjct: 1220 LANREESNRFKVAKKQTAS 1238


>B6QAM9_PENMQ (tr|B6QAM9) DNA topoisomerase 2 OS=Penicillium marneffei (strain ATCC
            18224 / CBS 334.59 / QM 7333) GN=PMAA_064030 PE=3 SV=1
          Length = 1696

 Score =  738 bits (1904), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/813 (47%), Positives = 521/813 (64%), Gaps = 21/813 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VLKTEVMTNILHFAEKKADQLLKKTDGGRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKSFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+   +PSLLK+P F++EF TPII+ +   
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPEFLIEFITPIIKVWKGD 683

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE W+E   N+ + W+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 684  PKNPTKSKSFFTMPEYEQWKEENKNDLS-WQHKYYKGLGTSTTEDAQIYFRDLDRHLKEF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R ++PG + DH   +I Y DF+NKELILFS AD
Sbjct: 743  HTMQDHEAQLIDLAFSKKKADERKEWLRQYKPGTFLDHSTKQITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  FK+ L K++KV +  G+VS  +AY HGE SL  TI+G
Sbjct: 803  NQRSIPSVVDGLKPGQRKVLYTCFKRNLKKDMKVVELAGHVSGMTAYQHGETSLQQTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +F++ D+ LL Y  
Sbjct: 863  LAQTFVGSNNLNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFNQQDEPLLTYNE 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++PL+L+NG++GIGTGWSS IPNYNP DI+AN++R+++ E   PM P
Sbjct: 923  DDGEKIEPELYVPVVPLILINGADGIGTGWSSSIPNYNPEDIVANLKRMMDGEEPEPMQP 982

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     +  Y  +G + E++++   ITELPIR WTQD+K  LE I       
Sbjct: 983  WFRGFNGEVTPQGPD-RYKFSGRIHELNDKEVEITELPIRTWTQDFKDKLEDIIKAE--- 1038

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   + EGL +KFKL+ TI+T+N+  FD EG+
Sbjct: 1039 KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKAAVDEGLEEKFKLSRTIATTNLVAFDPEGR 1098

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY     IL+EFF +RL YYERRKQ+ L   ++ L    N+ RFI  ++ G++VVS +
Sbjct: 1099 ITKYATVSDILKEFFAVRLKYYERRKQHQLSELQKQLDKFTNQARFIQMIIDGKLVVSKK 1158

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ EL++KGF P PK        VA A                           Y+
Sbjct: 1159 KKATLITELKEKGFKPFPK--------VAEAVKAGETEQVVEEEESSEEANTEMASNAYD 1210

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL M+I +LT E V+                     + +W             Q  +E 
Sbjct: 1211 YLLGMAIWSLTQERVEKLLRQIGDKEVEIDELIKLSKEEIWRRDLDGFINEWRFQLEEEH 1270

Query: 788  EDEKKRISQASKRTSTRDLGTKAAKKPPQPRKN 820
              E+K ++   +R S++ L T A+K P + RKN
Sbjct: 1271 RRERK-VASLGRRQSSK-LMTAASKGPGRKRKN 1301


>B7XIW3_ENTBH (tr|B7XIW3) DNA topoisomerase 2 OS=Enterocytozoon bieneusi (strain
            H348) GN=EBI_23976 PE=3 SV=1
          Length = 1159

 Score =  737 bits (1903), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 383/730 (52%), Positives = 494/730 (67%), Gaps = 59/730 (8%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N+ I+D +++++  KQ+  LKKTDG KT ++ GI KLEDAN AG + S +CTLILTEGDS
Sbjct: 369  NTDIIDKIITFSKIKQAVLLKKTDGVKTTKIVGIPKLEDANFAGTKRSSECTLILTEGDS 428

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AK LA+AGLSVVGRD YGVFPLRGKLLNVREASNKQIMDN EI  IKKILGLQ  K Y++
Sbjct: 429  AKTLAVAGLSVVGRDKYGVFPLRGKLLNVREASNKQIMDNAEISAIKKILGLQHGKTYTD 488

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
              SLRYGH+MIM DQD DGSHIKGL+INF+  F+PSLLK+  F+ EF TPI+RA      
Sbjct: 489  TTSLRYGHIMIMTDQDFDGSHIKGLIINFLDYFFPSLLKILGFLQEFITPIVRA-TKKKE 547

Query: 195  KLSFYSMPEYESWRENLGN-NATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDD 253
            K  F+++PEYE +++ +     +GW IKYYKGLGTST  + ++YF +L  H K F+  + 
Sbjct: 548  KYDFFTIPEYEKFKQQIEQIKDSGWVIKYYKGLGTSTTDDAKQYFNNLKLHVKTFIPVEL 607

Query: 254  YDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
             D   I++AF+KKKA+DRK WI  FEPG + D   S I  +DFVNKELILFS AD  RSI
Sbjct: 608  EDRELIDLAFNKKKADDRKEWIGRFEPGTFLDQSMSNITVRDFVNKELILFSMADNIRSI 667

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            PSV+DGLKPGQRK++F  FK+ L  EIKV Q +GYVSEHSAYHHGE SLA+TII +A DF
Sbjct: 668  PSVIDGLKPGQRKVIFSCFKRNLKTEIKVAQLVGYVSEHSAYHHGEASLAATIINLAHDF 727

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
            VGSNNINLL P GQFG+R LGGKD AS RYI+T LNP++R +FHE+D  +LE   ED   
Sbjct: 728  VGSNNINLLLPLGQFGSRLLGGKDSASPRYIFTNLNPLSRLIFHEHDIPILESQIEDNLV 787

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP++Y+PIIP+VLVNG++GIGTGWS+ IPN+NP D+I N++RLLN++    M P+YR +
Sbjct: 788  IEPTYYVPIIPMVLVNGTDGIGTGWSTNIPNHNPLDLIKNIKRLLNNQEPEEMIPYYRNY 847

Query: 494  KGIIEKSAKEGGYIVNGTV-EEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            KG I K    G YI  G V E I+++   + ELPI  WTQ YK++L+        + D +
Sbjct: 848  KGTITK-INAGKYISCGKVFENINKKEINVVELPIGVWTQAYKEYLDQA------IADNV 900

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+ F+    D  +DI I M   + +           KLTT+IST+NM  FD  GKIKKY 
Sbjct: 901  IKSFKDYSTDKTIDILIHMNNNEFSS----------KLTTSISTNNMVCFDRNGKIKKYH 950

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            N  +IL++F+ +RL++Y +RK Y L+     L  L NKVRFI GV++G I+++ R   ++
Sbjct: 951  NTLEILKDFYEVRLEFYNKRKIYRLKLLADELNKLKNKVRFIEGVITGSIIITQRPLNEI 1010

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            ++EL++K FT                                       +  +YEYLL M
Sbjct: 1011 ILELERKEFT---------------------------------------RYDNYEYLLDM 1031

Query: 733  SIGTLTLESV 742
             I +LT E +
Sbjct: 1032 KISSLTKEKI 1041


>A1CUL0_ASPCL (tr|A1CUL0) DNA topoisomerase 2 OS=Aspergillus clavatus (strain ATCC
            1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
            GN=ACLA_087000 PE=3 SV=1
          Length = 1735

 Score =  735 bits (1898), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 373/733 (50%), Positives = 504/733 (68%), Gaps = 22/733 (3%)

Query: 18   ILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKA 77
            +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEGDSAK 
Sbjct: 508  VMNNILHFAQAKADQMLKKTDGGRRTRMNN-PKLVDANKAGTKDGHHCTLILTEGDSAKG 566

Query: 78   LAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKS 137
            LAMAG +VVG D +GVFPLRGKLLNVR+AS +QI  N+EIQNIK  +GLQ  KEY + + 
Sbjct: 567  LAMAGRAVVGPDLFGVFPLRGKLLNVRDASFEQISKNQEIQNIKNFMGLQHKKEYIDTRG 626

Query: 138  LRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS---NGT 194
            LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPII+ +     N T
Sbjct: 627  LRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGDPKNPT 686

Query: 195  KL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDD 253
            K  SF++MPEYE+W+E  G+   GW+ KYYKGLGTST ++ + YFRDL +H K+F    D
Sbjct: 687  KQRSFFTMPEYEAWKEQHGHE-RGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEFHTLQD 745

Query: 254  YDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
            ++   IE+AFSKKKA++RK W+R F+PG + DH  ++I Y DF+NKELILFS AD QRSI
Sbjct: 746  HETELIELAFSKKKADERKEWLRQFKPGTFLDHSVAKITYTDFINKELILFSMADNQRSI 805

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            PSV+DGLKPGQRK+L+ SF++ L K++KV +  G+VS  +AY HG+ SL  TI+G+AQ F
Sbjct: 806  PSVIDGLKPGQRKVLYVSFRRNLKKDMKVVELAGHVSGMTAYQHGDASLQQTIVGLAQTF 865

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
            VGSNN+N L+P+G FG+R  GG+D AS+RYIYT L+P  R +FH  D+ LL Y  +DG+ 
Sbjct: 866  VGSNNVNCLEPSGNFGSRLQGGQDCASARYIYTRLSPFARRMFHPADEPLLTYNVDDGKQ 925

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP  Y+P++PL+L+NG++GIGTGWSS IPNYNP DI+ N++RL++ E + PM PW+RGF
Sbjct: 926  IEPENYVPVVPLLLINGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGEPIKPMQPWFRGF 985

Query: 494  KGIIEKSAKEGG-YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI--TDGSPNVKD 550
             G  E +A  G  +  +G ++E  ++   ITELPIR WTQD+K  LE I   D +P+   
Sbjct: 986  NG--EVTAIGGDRFKFSGIIKEAGDKEVEITELPIRTWTQDFKDKLEEIIKADKTPS--- 1040

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKK 610
              I+D++       V   I+M  + +   + EGL +KFKL+ TI+T+N+  FD EG+I K
Sbjct: 1041 -FIKDYKDYNTHTKVRFVIQMDEKHMQSALSEGLEEKFKLSKTIATTNLVAFDPEGRITK 1099

Query: 611  YENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKA 670
            Y + + IL+EFF +RL +YERRKQY L   +R L  L N+ RF+  ++ G +V+S +KK 
Sbjct: 1100 YASVDDILKEFFTVRLKFYERRKQYQLSELQRELDKLSNQARFVQMIIDGALVISKKKKP 1159

Query: 671  DLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLL 730
             L+ EL++KGF  +PK    A+   AG                            Y+YLL
Sbjct: 1160 VLIAELKEKGFKAIPK---VADAVKAGEDEPVVEEGEESEEAEDTEVQSNA----YDYLL 1212

Query: 731  SMSIGTLTLESVQ 743
             MS+ +LT E V+
Sbjct: 1213 GMSLWSLTQERVE 1225


>Q8X1U4_ASPNG (tr|Q8X1U4) DNA topoisomerase 2 (Fragment) OS=Aspergillus niger
            GN=TOP 2 PE=3 SV=1
          Length = 1391

 Score =  735 bits (1897), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 375/736 (50%), Positives = 497/736 (67%), Gaps = 18/736 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 436  VLKTAVMDNILHFAQQKADQMLKKTDGGRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 494

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK  LGLQ  KEY
Sbjct: 495  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNQEIQNIKNFLGLQHKKEY 554

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPI++ +   
Sbjct: 555  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIVKVWKGD 614

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE+W E    +  GW  KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 615  PKNPTKQRSFFTMPEYEAWAEE-HQHERGWDHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 673

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+NKELILFS AD
Sbjct: 674  HTMQDNEAELIELAFSKKKADERKEWLRQFKPGTFLDHSVEKITYTDFINKELILFSMAD 733

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 734  NVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHGDVSLQQTIVG 793

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH +D+ LL Y  
Sbjct: 794  LAQTFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRIFHASDEPLLTYNV 853

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG++IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+N E + PM P
Sbjct: 854  DDGKTIEPEVYMPVVPMILINGADGIGTGWSSSIPNYNPEDVVDNLKRLMNGEEIKPMQP 913

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +  S     +  +G ++E  E+   ITELPIR WTQD+K  LE I       
Sbjct: 914  WFRGFTGEV-TSIGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKDKLEDIIKAE--- 969

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   ++EGL +KFKLT TI+T+N+  FD EG+
Sbjct: 970  KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKSAVEEGLEEKFKLTKTIATTNLVAFDPEGR 1029

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY   + IL+EFF +RL YYERRKQY L   ++ L  L N+ RF+  ++ GE+VVS +
Sbjct: 1030 ITKYATVDDILKEFFAVRLKYYERRKQYQLNEMQKELEKLSNQARFVQMIIDGELVVSKK 1089

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KK  L++EL+ KGF P PK   +A+   A                             Y+
Sbjct: 1090 KKNVLVVELKDKGFKPFPKVADAAKAGEAEPAAEDEEESEDVDDTSNLSNA-------YD 1142

Query: 728  YLLSMSIGTLTLESVQ 743
            YLL M+I +LT E V+
Sbjct: 1143 YLLGMAIWSLTQERVE 1158


>Q8ILC8_PLAF7 (tr|Q8ILC8) DNA topoisomerase 2 OS=Plasmodium falciparum (isolate
            3D7) GN=PF14_0316 PE=3 SV=1
          Length = 1472

 Score =  734 bits (1896), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 381/762 (50%), Positives = 503/762 (66%), Gaps = 16/762 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTLI 68
            V  S IL  +L WA  K   +LKK          +R+ GI KLEDANDAG + S +CTLI
Sbjct: 437  VLKSPILSNILLWAQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLI 496

Query: 69   LTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ- 127
            LTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI +I+GL  
Sbjct: 497  LTEGDSAKTSCLAGLSIVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDI 556

Query: 128  QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             +K   ++K LRYG LMIM DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI++
Sbjct: 557  TDKNKDDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVK 616

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                   + SF+++ EYE W+EN   N  GWKIKYYKGLGTST +E ++YF D+  H+  
Sbjct: 617  V-QKGSQEYSFFTIAEYEQWKEN--TNLLGWKIKYYKGLGTSTDREFKQYFSDIKNHKIM 673

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR 
Sbjct: 674  FLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRY 733

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TII
Sbjct: 734  DTERSIPNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTII 793

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
             MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR +F+E DD +L+YL
Sbjct: 794  NMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYL 853

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
            NE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N++R +N E ++PM 
Sbjct: 854  NEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMV 913

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWY+ FKG IE + K  GY   G + +ID  +  ITELPI+KWTQDYK+FLE +     +
Sbjct: 914  PWYKDFKGRIESNGK-TGYETIGIINKIDNDTLEITELPIKKWTQDYKEFLEELL---TD 969

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
             K  LI D+  N     +   I+M   K+    +EGL K FKL +T++T+NM LFD   K
Sbjct: 970  EKHQLILDYIDNSSHEDICFTIKMDPAKLQKAEEEGLEKVFKLKSTLTTTNMTLFDPNLK 1029

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            +++Y     IL+EF   RL  YE RK Y++   E+   ++ NK +FIL +V+ E++V+ +
Sbjct: 1030 LQRYSTELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKK 1089

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KK  L+ EL +KG+ P     K  + ++                             DY+
Sbjct: 1090 KKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLDAADNPEDNEEIIAGITVK----DYD 1145

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            YLLSM I +LTLE V+                     ++MW+
Sbjct: 1146 YLLSMPIFSLTLEKVEDLLTQLKEKERELEILRNITVETMWL 1187


>G3YF10_ASPNA (tr|G3YF10) DNA topoisomerase 2 OS=Aspergillus niger (strain ATCC
            1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
            NRRL 328 / USDA 3528.7) GN=topB PE=3 SV=1
          Length = 1639

 Score =  734 bits (1896), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/746 (50%), Positives = 501/746 (67%), Gaps = 24/746 (3%)

Query: 3    FYTYMLQMFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNS 62
            FY  +L+      + +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++ 
Sbjct: 437  FYKKILK------TAVMENILHFAQQKADQMLKKTDGGRRSRMNN-PKLTDANKAGTKDG 489

Query: 63   DKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKK 122
              CTLILTEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK 
Sbjct: 490  HHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNQEIQNIKN 549

Query: 123  ILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFT 182
             LGLQ  KEY++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF 
Sbjct: 550  FLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFI 609

Query: 183  TPIIRAFHS---NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYF 238
            TPI++ +     N TK  SF++MPEYE+W E    +  GW  KYYKGLGTST ++ + YF
Sbjct: 610  TPIVKVWKGDPKNPTKQRSFFTMPEYEAWAEE-HQHERGWDHKYYKGLGTSTTEDAQVYF 668

Query: 239  RDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVN 298
            RDL +H K+F    D +   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+N
Sbjct: 669  RDLDRHLKEFHTMQDNEAELIELAFSKKKADERKEWLRQFKPGTFLDHSVEKITYTDFIN 728

Query: 299  KELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHG 358
            KELILFS AD  RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG
Sbjct: 729  KELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHG 788

Query: 359  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHE 418
            + SL  TI+G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH 
Sbjct: 789  DISLQQTIVGLAQTFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRIFHA 848

Query: 419  NDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL 478
            +D+ LL Y  +DG++IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+
Sbjct: 849  SDEPLLTYNVDDGKTIEPEVYMPVVPMILINGADGIGTGWSSSIPNYNPEDVVDNLKRLM 908

Query: 479  NDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFL 538
            N E + PM PW+RGF G +  S     +  +G ++E  E+   ITELPIR WTQD+K  L
Sbjct: 909  NGEEIKPMQPWFRGFTGEV-TSIGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKDKL 967

Query: 539  ESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTS 597
            E I       K P  I+D++       V   I+M  + +   ++EGL +KFKLT TI+T+
Sbjct: 968  EDIIKAE---KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKSAVEEGLEEKFKLTKTIATT 1024

Query: 598  NMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGV 657
            N+  FD EG+I KY   + IL+EFF +RL YYERRKQY L   ++ L  L N+ RF+  +
Sbjct: 1025 NLVAFDPEGRITKYATVDDILKEFFAVRLKYYERRKQYQLNEMQKELEKLSNQARFVQMI 1084

Query: 658  VSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXX 717
            + GE+VVS +KK  L++EL+ KGF P PK   +A+   A                     
Sbjct: 1085 IDGELVVSKKKKNVLVVELKDKGFKPFPKVADAAKAGEAEPAAEDEEESEDVDDTSNLSN 1144

Query: 718  XXXXKRGDYEYLLSMSIGTLTLESVQ 743
                    Y+YLL M+I +LT E V+
Sbjct: 1145 A-------YDYLLGMAIWSLTQERVE 1163


>A5AB02_ASPNC (tr|A5AB02) DNA topoisomerase 2 OS=Aspergillus niger (strain CBS
            513.88 / FGSC A1513) GN=An08g08550 PE=3 SV=1
          Length = 1712

 Score =  734 bits (1896), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/746 (50%), Positives = 501/746 (67%), Gaps = 24/746 (3%)

Query: 3    FYTYMLQMFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNS 62
            FY  +L+      + +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++ 
Sbjct: 510  FYKKILK------TAVMENILHFAQQKADQMLKKTDGGRRSRMNN-PKLTDANKAGTKDG 562

Query: 63   DKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKK 122
              CTLILTEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK 
Sbjct: 563  HHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNQEIQNIKN 622

Query: 123  ILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFT 182
             LGLQ  KEY++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF 
Sbjct: 623  FLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFI 682

Query: 183  TPIIRAFHS---NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYF 238
            TPI++ +     N TK  SF++MPEYE+W E    +  GW  KYYKGLGTST ++ + YF
Sbjct: 683  TPIVKVWKGDPKNPTKQRSFFTMPEYEAWAEE-HQHERGWDHKYYKGLGTSTTEDAQVYF 741

Query: 239  RDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVN 298
            RDL +H K+F    D +   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+N
Sbjct: 742  RDLDRHLKEFHTMQDNEAELIELAFSKKKADERKEWLRQFKPGTFLDHSVEKITYTDFIN 801

Query: 299  KELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHG 358
            KELILFS AD  RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG
Sbjct: 802  KELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHG 861

Query: 359  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHE 418
            + SL  TI+G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH 
Sbjct: 862  DISLQQTIVGLAQTFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRIFHA 921

Query: 419  NDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL 478
            +D+ LL Y  +DG++IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+
Sbjct: 922  SDEPLLTYNVDDGKTIEPEVYMPVVPMILINGADGIGTGWSSSIPNYNPEDVVDNLKRLM 981

Query: 479  NDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFL 538
            N E + PM PW+RGF G +  S     +  +G ++E  E+   ITELPIR WTQD+K  L
Sbjct: 982  NGEEIKPMQPWFRGFTGEV-TSIGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKDKL 1040

Query: 539  ESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTS 597
            E I       K P  I+D++       V   I+M  + +   ++EGL +KFKLT TI+T+
Sbjct: 1041 EDIIKAE---KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKSAVEEGLEEKFKLTKTIATT 1097

Query: 598  NMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGV 657
            N+  FD EG+I KY   + IL+EFF +RL YYERRKQY L   ++ L  L N+ RF+  +
Sbjct: 1098 NLVAFDPEGRITKYATVDDILKEFFAVRLKYYERRKQYQLNEMQKELEKLSNQARFVQMI 1157

Query: 658  VSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXX 717
            + GE+VVS +KK  L++EL+ KGF P PK   +A+   A                     
Sbjct: 1158 IDGELVVSKKKKNVLVVELKDKGFKPFPKVADAAKAGEAEPAAEDEEESEDVDDTSNLSN 1217

Query: 718  XXXXKRGDYEYLLSMSIGTLTLESVQ 743
                    Y+YLL M+I +LT E V+
Sbjct: 1218 A-------YDYLLGMAIWSLTQERVE 1236


>A7ANB1_BABBO (tr|A7ANB1) DNA topoisomerase 2 OS=Babesia bovis GN=BBOV_III004820
            PE=3 SV=1
          Length = 1437

 Score =  734 bits (1895), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 406/846 (47%), Positives = 531/846 (62%), Gaps = 41/846 (4%)

Query: 6    YMLQMFAVAN---SGILDTLLSWADFKQSKDLKK-TDGTKT-QRLRGIVKLEDANDAGGR 60
            Y++   AVA    S + + +LS+A  + + +LKK    TK   RL GI KLEDAN+AG R
Sbjct: 372  YIMNPKAVAQILKSTLTERILSFAQGRLNIELKKKMKVTKAVNRLTGIPKLEDANNAGTR 431

Query: 61   NSDKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNI 120
            ++  CTLILTEGDSAK   +AGLSVVGRD+YGVFPL+GKLLNVR+AS KQ++ N EIQNI
Sbjct: 432  HARNCTLILTEGDSAKTSCLAGLSVVGRDNYGVFPLKGKLLNVRDASYKQLVQNAEIQNI 491

Query: 121  KKILGLQ-QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMV 179
             KI+GL    KE +    LRYG +MIM DQD+DGSHIKGLLIN +H FWP +++   F+ 
Sbjct: 492  LKIMGLDVSKKEQTTPDGLRYGSIMIMTDQDYDGSHIKGLLINLLHYFWPKMIQCRGFIR 551

Query: 180  EFTTPIIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFR 239
            EF TPII+A   +   LSF+++ +Y  W ++   N  GWKIKYYKGLGTST +E +EYF 
Sbjct: 552  EFVTPIIKATKGDSV-LSFFTVQDYVRWVQS--TNVAGWKIKYYKGLGTSTDKEFKEYFV 608

Query: 240  DLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNK 299
            ++ +H  DF++ED+ D  +I++AF+KK+ +DRK+W++++E G   DH   ++ Y DF+NK
Sbjct: 609  NIQQHLIDFIYEDNADDDSIDLAFNKKRVDDRKLWMQSYEHGTTVDHSIKKLRYTDFINK 668

Query: 300  ELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGE 359
            ELI FS  D +RSIPSVVDG KPGQRK+LF   K+ L  E KV Q  GYV+EHSAYHHGE
Sbjct: 669  ELIQFSIYDTERSIPSVVDGWKPGQRKVLFGCLKRNLVGECKVAQLTGYVAEHSAYHHGE 728

Query: 360  QSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHEN 419
             SL  TII MAQ+FVGSNNIN+L+P GQFG+R  GGKD +++RYI+T+LNPITR +F E 
Sbjct: 729  ASLQQTIINMAQNFVGSNNINVLEPCGQFGSRKEGGKDASAARYIFTKLNPITRLIFVEE 788

Query: 420  DDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLN 479
            DD +LEY NE+G++IEP +YIP IP+VLVNGSEGIGTG+SS IPNYNP DII N++R LN
Sbjct: 789  DDNILEYQNEEGQTIEPMYYIPTIPMVLVNGSEGIGTGFSSQIPNYNPLDIIDNLKRYLN 848

Query: 480  DETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQS-FRITELPIRKWTQDYKQFL 538
            +  M PM PWY  F G IE + K GG+   G  + +DE     ITELPIRKWT DY+ FL
Sbjct: 849  NVDMKPMVPWYHKFTGEIEPNDK-GGFDCLGNYQWLDENGLLEITELPIRKWTHDYRVFL 907

Query: 539  ESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSN 598
            ES+  G  N K+PLI  F  N     V   + +  E I  ++ EG+ K FKL T+I+T+N
Sbjct: 908  ESLEQGV-NGKEPLILGFVDNSTHESVHFTLNVNPECIEEVINEGVDKVFKLRTSIATTN 966

Query: 599  MHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVV 658
            M LFDA  K+K+Y N  +I+ +F  +RL  YE+RK Y++ N + LL  + N+VRFI  VV
Sbjct: 967  MTLFDANKKLKRYSNELEIIRDFAAVRLATYEKRKTYLINNLKLLLRRISNQVRFIHMVV 1026

Query: 659  SGEIVVSNRKKADLLMELQQKGFTPMPKKGK-SAEPQVAGAXXXXXXXXXXXXXXXXXXX 717
            + E+V+  + KA L+ EL+  GF       K S EP                        
Sbjct: 1027 NEELVLFKKAKATLVAELRDLGFDSNTDILKGSEEPSTLNEPVTPSRRSGTQDAPG---- 1082

Query: 718  XXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM---XXXXX 774
                   DY YLL+M + +LTLE VQ                  T +  MWM        
Sbjct: 1083 ------ADYNYLLNMPLWSLTLEQVQKLNEEHAQKENQLRILLETTATDMWMDDLNKVEV 1136

Query: 775  XXXXXXXQDGKEAEDE-----------KKRISQASKRTSTRDLGTKAAKKPPQPRKNTKK 823
                   QD   A              K++ SQ+ + T+T     KA + PP  R N+  
Sbjct: 1137 AIKMAYQQDEITAPTPSHAALMQLTKIKRKASQSQRSTAT----PKATQSPPSSRGNSTS 1192

Query: 824  TKNAES 829
              N  S
Sbjct: 1193 RSNKRS 1198


>C5KAQ6_PERM5 (tr|C5KAQ6) DNA topoisomerase 2 OS=Perkinsus marinus (strain ATCC
            50983 / TXsc) GN=Pmar_PMAR005137 PE=3 SV=1
          Length = 1579

 Score =  734 bits (1895), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 377/755 (49%), Positives = 502/755 (66%), Gaps = 32/755 (4%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLK---KTDGTKTQ-RLRGIVKLEDANDAGGRNSDKC 65
            M  V +SGI+D +++WA FKQ+  L+   K  GT  Q R+ G+ KLEDANDAGGR SD+C
Sbjct: 403  MKKVLSSGIVDQVVNWAKFKQTATLQSKIKVGGTGGQTRIFGVPKLEDANDAGGRYSDRC 462

Query: 66   TLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILG 125
            TLILTEGDSAKALA+AGL V+GRD YGVFPLRGK+LNVREAS KQ +DN+EIQ I KI+G
Sbjct: 463  TLILTEGDSAKALAVAGLGVIGRDKYGVFPLRGKVLNVREASYKQTVDNKEIQAILKIIG 522

Query: 126  LQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPI 185
            L+  K Y  VK LRYG +M+M DQD DGSHIKGLLIN +H +WP LL+   FM EF TPI
Sbjct: 523  LEPRKAYDGVKGLRYGSIMVMTDQDLDGSHIKGLLINLVHHWWPGLLQTRGFMKEFVTPI 582

Query: 186  IRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHR 245
            ++       +LSF+++ EYE W+ N  N+  GWKIKYYKGLGTST +E ++YF  + KH 
Sbjct: 583  VKCVKGR-RELSFFTLTEYEEWKRN-NNDGKGWKIKYYKGLGTSTSKEAQQYFSQISKHS 640

Query: 246  KDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFS 305
              F + D  DG AI+MAF+KK+A+DRK WI  +  G+  DH  + + Y DF+NKEL+ FS
Sbjct: 641  LSFDYRDGDDGEAIDMAFNKKRADDRKEWINGYADGDCVDHSKASLRYLDFINKELVQFS 700

Query: 306  RADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLAST 365
            + D+ RSIPS+VDG KP QRK+LFC+ K+ L  + KV QF+GYVSEHSAYHHGEQSL S 
Sbjct: 701  KYDVMRSIPSMVDGFKPSQRKVLFCALKRNLKSDTKVAQFVGYVSEHSAYHHGEQSLESC 760

Query: 366  IIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLE 425
            I+GMAQDF GSNN+NLL P+GQFGTR  GGKD AS RYIYT L+  TR +FH +DD +LE
Sbjct: 761  IVGMAQDFTGSNNLNLLFPSGQFGTRQQGGKDAASGRYIYTRLSKYTRTIFHPDDDDVLE 820

Query: 426  YLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVP 485
            YL E+G+SIEP WY PIIP+VLVNG+EGIGTGWS+ + +Y+PR+II  +R L+    +  
Sbjct: 821  YLTEEGQSIEPKWYCPIIPMVLVNGAEGIGTGWSTNVLSYDPREIIHLLRALIRGVELHD 880

Query: 486  MDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            + PWYRGF G +E++ K G   V       D+++  ITELP++ WTQ+YK  L+++    
Sbjct: 881  IHPWYRGFTGSVERNDKNGYDFVGKVRMASDDRTVDITELPVKTWTQNYKD-LDTLV--- 936

Query: 546  PNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE-GLLKKFKLTTTISTSNMHLFDA 604
              V   L+  +     +  V  +  ++ E    ++   GL K FKL +  ST+NM LFD 
Sbjct: 937  --VSVILLGRYHT---EHSVHFKCTLQNEAAKSVVDSLGLEKAFKLRSAFSTTNMVLFDR 991

Query: 605  EGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVV 664
            +GKI++Y++   I+++F  LRLD Y +RK  ++    + +L+L NK RF++ V++GEIV 
Sbjct: 992  DGKIRRYDSVLDIIKDFADLRLDMYVKRKDSLIAKLTKEILILSNKCRFVMMVINGEIVF 1051

Query: 665  SNRKKADLLMELQQKGFTPMPK-------------KGKSAEPQVAGA---XXXXXXXXXX 708
              +K   L+ EL++K F  M +             KGK+     A +             
Sbjct: 1052 QKKKIVQLMEELKRKKFMTMMEIDAQTRAAKIGSLKGKTVAASSATSDEVKSEGESSEEE 1111

Query: 709  XXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                         KR  Y+YLL+MS+ +LTLE V+
Sbjct: 1112 EEADEEAKVEKQQKRSGYDYLLAMSMWSLTLERVE 1146


>I7ADX3_ENCRO (tr|I7ADX3) DNA topoisomerase 2 OS=Encephalitozoon romaleae (strain
            SJ-2008) GN=EROM_040310 PE=3 SV=1
          Length = 1144

 Score =  734 bits (1895), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 377/732 (51%), Positives = 493/732 (67%), Gaps = 63/732 (8%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             + N+ I+  + S+A  +QS  LKKTDG KT RL GI KLEDAN AG   S  CTLILTE
Sbjct: 369  VIKNTSIVQKVASFAKARQSLQLKKTDGAKTSRLSGIPKLEDANFAGTNKSKDCTLILTE 428

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK LA++GLSVVGRD YGVFPLRGKLLNVREAS+KQIM+N EI +IKKILGLQ NK 
Sbjct: 429  GDSAKTLAVSGLSVVGRDTYGVFPLRGKLLNVREASHKQIMENSEISSIKKILGLQHNKV 488

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y +  SLRYGH+MIM DQDHDGSHIKGL+INF+  F+PSLLK+P F+ EF TPIIRA   
Sbjct: 489  YEDTSSLRYGHVMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLQEFITPIIRA-TK 547

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
             G    F+++PEYE ++ +      GW IKYYKGLGTST  + ++YF +L  H K F   
Sbjct: 548  KGQVRDFFTLPEYEEFKRS----EEGWNIKYYKGLGTSTSADAKQYFSNLPIHVKHFTPL 603

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQR 311
             D D   I++AF+KKKA+ RK W+ +FEPG + D   S I+  DFVNKELILFS AD  R
Sbjct: 604  VDEDKELIDLAFNKKKADARKTWLLSFEPGTFLDQSLSHISISDFVNKELILFSMADNIR 663

Query: 312  SIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQ 371
            SIPS+VDGLKPGQRK++F  FK+ L  EIKV Q +GYVSE SAYHHGEQSL STI+ +AQ
Sbjct: 664  SIPSLVDGLKPGQRKVMFSCFKRNLRSEIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQ 723

Query: 372  DFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDG 431
            DFVGSNNINLL P GQFG+R  GGKD AS RYI+T L+P+TR +F+ENDD +L YLN+D 
Sbjct: 724  DFVGSNNINLLLPIGQFGSRLQGGKDAASPRYIFTSLSPLTRLIFNENDDAILNYLNDDN 783

Query: 432  RSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYR 491
             SIEP +Y+PIIP+VLVNG+EGIGTGWS+ IPN+NP D++ N+RR++  E  V M P+YR
Sbjct: 784  LSIEPEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPIDVVENIRRMIRGEDPVEMVPYYR 843

Query: 492  GFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP 551
             F+G IEK   EG + V+G  +   +    ITELP+  WT +YK+FLES+      V+  
Sbjct: 844  NFRGSIEKIG-EGKFQVSGVYK--GDMDLEITELPVGTWTLNYKEFLESL------VQAG 894

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
            +++DF++   +  V+  +++             +   KL+ TI+ +NM  FD    IKKY
Sbjct: 895  VVKDFKEYHTEKTVNFTVKLAKH----------VSNLKLSNTITINNMVCFDENLGIKKY 944

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
              P+ IL +F+ +RL YY  RK  +++  +  L+ L+NKV+FI  V +G ++++ R+KA+
Sbjct: 945  STPKDILRDFYDVRLRYYSMRKDNMMKVMKDELVKLENKVKFIKEVSTGGLIINRRRKAE 1004

Query: 672  LLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLS 731
            ++ +L+ +G+                                        +  DYEYLL 
Sbjct: 1005 IIFDLESRGYA---------------------------------------RVDDYEYLLG 1025

Query: 732  MSIGTLTLESVQ 743
            MSI +LT+E ++
Sbjct: 1026 MSILSLTVERIE 1037


>Q7Z2D0_PLAFA (tr|Q7Z2D0) DNA topoisomerase 2 OS=Plasmodium falciparum GN=TopoII
            PE=3 SV=1
          Length = 1397

 Score =  734 bits (1894), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 381/762 (50%), Positives = 503/762 (66%), Gaps = 16/762 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTLI 68
            V  S IL  +L WA  K   +LKK          +R+ GI KLEDANDAG + S +CTLI
Sbjct: 437  VLKSPILSNILLWAQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLI 496

Query: 69   LTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ- 127
            LTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI +I+GL  
Sbjct: 497  LTEGDSAKTSCLAGLSIVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDI 556

Query: 128  QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             +K   ++K LRYG LMIM DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI++
Sbjct: 557  TDKNKDDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVK 616

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                   + SF+++ EYE W+EN   N  GWKIKYYKGLGTST +E ++YF D+  H+  
Sbjct: 617  V-QKGSQEYSFFTIAEYEQWKEN--TNLLGWKIKYYKGLGTSTDREFKQYFSDIKNHKIM 673

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR 
Sbjct: 674  FLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRY 733

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TII
Sbjct: 734  DTERSIPNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTII 793

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
             MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR +F+E DD +L+YL
Sbjct: 794  NMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYL 853

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
            NE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N++R +N E ++PM 
Sbjct: 854  NEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMV 913

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWY+ FKG IE + K  GY   G + +ID  +  ITELPI+KWTQDYK+FLE +     +
Sbjct: 914  PWYKDFKGRIESNGK-TGYETIGIINKIDNDTLEITELPIKKWTQDYKEFLEELL---TD 969

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
             K  LI D+  N     +   I+M   K+    +EGL K FKL +T++T+NM LFD   K
Sbjct: 970  EKHQLILDYIDNSSHEDICFTIKMDPAKLQKAEEEGLEKVFKLKSTLTTTNMTLFDPNLK 1029

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            +++Y     IL+EF   RL  YE RK Y++   E+   ++ NK +FIL +V+ E++V+ +
Sbjct: 1030 LQRYSTELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKK 1089

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KK  L+ EL +KG+ P     K  + ++                             DY+
Sbjct: 1090 KKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLDAADNPEDNEEIIAGITVK----DYD 1145

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            YLLSM I +LTLE V+                     ++MW+
Sbjct: 1146 YLLSMPIFSLTLEKVEDLLTQLKEKERELEILRNITVETMWL 1187


>J9VEP2_CRYNH (tr|J9VEP2) DNA topoisomerase 2 OS=Cryptococcus neoformans var.
            grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 /
            FGSC 9487) GN=CNAG_00377 PE=3 SV=1
          Length = 1247

 Score =  733 bits (1893), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 384/731 (52%), Positives = 488/731 (66%), Gaps = 67/731 (9%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            VA +GI+D +L+WA FKQ + LKKTDGTK  R+ GIVKLEDAN+AGGRNS  CTLILTEG
Sbjct: 488  VAKTGIIDNVLNWARFKQDQILKKTDGTKRSRISGIVKLEDANNAGGRNSKNCTLILTEG 547

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALA++GL+VVGRD YGVFPLRGKLLNVREA + QI+ N EIQ+IK+ILGL+ N++Y
Sbjct: 548  DSAKALAVSGLAVVGRDEYGVFPLRGKLLNVREAGHDQIIKNVEIQHIKQILGLKHNQDY 607

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            + V SLRYGHLMIM DQDHDGSHIKGL+INF+  F+PSLL++P+F+VEF TPI++ +   
Sbjct: 608  ATVDSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLRIPNFLVEFITPIVKVWKGK 667

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
              ++SFY+MP+YE W+    NN  GW+ KYYKGLGTST  + ++YF DL KHR  F    
Sbjct: 668  -KEISFYTMPQYEEWKSQ-NNNGRGWESKYYKGLGTSTSADAKKYFSDLDKHRLAFETMQ 725

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   I+MAF+KKKA+DRK W+R F+PG Y DH    +   DFVNKELILFS AD  RS
Sbjct: 726  PEDRQLIDMAFNKKKADDRKEWLRQFKPGTYLDHDVQSLPISDFVNKELILFSMADNIRS 785

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IPSV DGLKPGQRK+LF  FK+ L KEIKV Q  GYVSE +AYHHGE SL STI+G+AQ+
Sbjct: 786  IPSVADGLKPGQRKVLFGCFKRNLTKEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQN 845

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINLL PNGQFGTR  GGKD AS+RYI+T L  +TR +FH  DD LL YL EDG 
Sbjct: 846  FVGSNNINLLDPNGQFGTRLAGGKDAASARYIFTNLPRMTRAIFHPADDGLLNYLVEDGM 905

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             IEP +++P +P+VL+NG++GIGT                                    
Sbjct: 906  RIEPDYFMPTVPMVLINGADGIGT------------------------------------ 929

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
              G+IEK        +N T       +  ITELPIR+WTQD+K+ LE +T G+  V    
Sbjct: 930  VSGVIEK--------INDT-------TLEITELPIRRWTQDFKEMLEEMTTGTDKVPQ-T 973

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+D+ ++  D  V   + M  + +A   +EG  K+F+LTTT+ T NM  FD  GKIKKY 
Sbjct: 974  IKDYEEHHTDTTVHFRVHMTEKNLADAEKEGFDKRFRLTTTLGTGNMVCFDLNGKIKKYA 1033

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +PE+ILEEFF  RL+YY  RKQ++ +   R    L N+ RF+  +++ E+VVS +++ D+
Sbjct: 1034 SPEEILEEFFHKRLEYYGHRKQHLADELNRQFERLSNQARFVHMIITKELVVSGKRRPDI 1093

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + EL+   F P PKK K+ E    GA                       +  DY+YLL M
Sbjct: 1094 VTELRNLKFRPFPKKEKAKEEGENGA-------------AEEEEEWDEGQASDYDYLLGM 1140

Query: 733  SIGTLTLESVQ 743
            +I +LT E V+
Sbjct: 1141 AIWSLTSEKVE 1151


>F2PYI8_TRIEC (tr|F2PYI8) DNA topoisomerase 2 OS=Trichophyton equinum (strain ATCC
            MYA-4606 / CBS 127.97) GN=TEQG_06009 PE=3 SV=1
          Length = 1678

 Score =  733 bits (1893), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 369/736 (50%), Positives = 495/736 (67%), Gaps = 21/736 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  N
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGN 683

Query: 193  G-----TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                  TK SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K 
Sbjct: 684  PKNPTHTK-SFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQ 741

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F    D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS A
Sbjct: 742  FHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMA 801

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+
Sbjct: 802  DNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIV 861

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL   
Sbjct: 862  GLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNN 921

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM 
Sbjct: 922  IDDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMK 981

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PW+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I      
Sbjct: 982  PWFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE-- 1037

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 1038 -KVPSFIKDYKDYNTHTDVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEG 1096

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 1097 RITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISK 1156

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KKA L+ ELQ+KGF P PK   + EP  AG                            Y
Sbjct: 1157 KKKAVLIQELQEKGFKPFPKVVGTPEPGEAGDVEEEEDEEEETTTAAASSDA-------Y 1209

Query: 727  EYLLSMSIGTLTLESV 742
            +YLLSM + +LT E V
Sbjct: 1210 DYLLSMPLWSLTQERV 1225


>Q8X1U1_PENMA (tr|Q8X1U1) DNA topoisomerase 2 (Fragment) OS=Penicillium marneffei
            GN=TOP 2 PE=3 SV=1
          Length = 1162

 Score =  733 bits (1892), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 372/736 (50%), Positives = 496/736 (67%), Gaps = 19/736 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 395  VLKTEVMTNILHFAEKKADQLLKKTDGGRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 453

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 454  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKSFIGLQHKKEY 513

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+   +PSLLK+P F++EF TPII+ +   
Sbjct: 514  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPEFLIEFITPIIKVWKGD 573

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE W+E   N+ + W+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 574  PKNPTKSKSFFTMPEYEQWKEENKNDLS-WQHKYYKGLGTSTTEDAQIYFRDLDRHLKEF 632

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R ++PG + DH   +I Y DF+NKELILFS AD
Sbjct: 633  HTMQDHEAQLIDLAFSKKKADERKEWLRQYKPGTFLDHSTKQITYTDFINKELILFSMAD 692

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  FK+ L K++KV +  G+VS  +AY HGE SL  TI+G
Sbjct: 693  NQRSIPSVVDGLKPGQRKVLYTCFKRNLKKDMKVVELAGHVSGMTAYQHGETSLQQTIVG 752

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +F++ D+ LL Y  
Sbjct: 753  LAQTFVGSNNLNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFNQQDEPLLTYNE 812

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++PL+L+NG++GIGTGWSS IPNYNP DI+AN++R+++ E   PM P
Sbjct: 813  DDGEKIEPELYVPVVPLILINGADGIGTGWSSSIPNYNPEDIVANLKRMMDGEEPEPMQP 872

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     +  Y  +G + E++++   ITELPIR WTQD+K  LE I       
Sbjct: 873  WFRGFNGEVTPQGPD-RYKFSGRIHELNDKEVEITELPIRTWTQDFKDKLEDIIKAE--- 928

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   ++EGL +KFKL+ TI+T+N+  FD EG+
Sbjct: 929  KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKAAVEEGLEEKFKLSRTIATTNLVAFDPEGR 988

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY     IL+EFF +RL YYERRKQ+ L   ++ L    N+ RFI  ++ G++VVS +
Sbjct: 989  ITKYATVSDILKEFFAVRLKYYERRKQHQLSELQKQLDKFTNQARFIQMIIDGKLVVSKK 1048

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ EL++KGF P PK        VA A                           Y+
Sbjct: 1049 KKATLITELKEKGFKPFPK--------VAEAVKAGETEQVVEEEESSEEANTEMASNAYD 1100

Query: 728  YLLSMSIGTLTLESVQ 743
            YLL M+I +LT E V+
Sbjct: 1101 YLLGMAIWSLTQERVE 1116


>F2SCP4_TRIRC (tr|F2SCP4) DNA topoisomerase 2 OS=Trichophyton rubrum (strain ATCC
            MYA-4607 / CBS 118892) GN=TERG_01475 PE=3 SV=1
          Length = 1674

 Score =  733 bits (1891), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/735 (50%), Positives = 494/735 (67%), Gaps = 19/735 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +   
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 683

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N T   SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 684  PKNPTHTKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 743  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + ++IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 803  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRRDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 863  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 923  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMKP 982

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 983  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEITELPIRTWTQDFKDKLEEIIKAE--- 1037

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 1038 KVPSFIKDYKDYNTHTNVHFVIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 1097

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 1098 ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1157

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1158 KKAVLIQELQEKGFKPFPKVVGTPEPGEAGDIEEEEDEEEETASAAVSSDA-------YD 1210

Query: 728  YLLSMSIGTLTLESV 742
            YLLSM + +LT E V
Sbjct: 1211 YLLSMPLWSLTQERV 1225


>G7X785_ASPKW (tr|G7X785) DNA topoisomerase 2 OS=Aspergillus kawachii (strain NBRC
            4308) GN=AKAW_01222 PE=3 SV=1
          Length = 1695

 Score =  732 bits (1890), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/747 (50%), Positives = 505/747 (67%), Gaps = 26/747 (3%)

Query: 3    FYTYMLQMFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNS 62
            FY  +L+      + +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++ 
Sbjct: 490  FYKKILK------TAVMENILHFAQQKADQMLKKTDGGRRSRMNN-PKLTDANKAGTKDG 542

Query: 63   DKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKK 122
              CTLILTEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK 
Sbjct: 543  HHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNQEIQNIKN 602

Query: 123  ILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFT 182
             LGLQ  KEY++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF 
Sbjct: 603  FLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFI 662

Query: 183  TPIIRAFHS---NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYF 238
            TPI++ +     N TK  SF++MPEYE+W E    +  GW  KYYKGLGTST ++ + YF
Sbjct: 663  TPIVKVWKGDPKNPTKQRSFFTMPEYEAWAEE-HKHERGWDHKYYKGLGTSTTEDAQVYF 721

Query: 239  RDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVN 298
            RDL +H K+F    D +   IE+AFSKKKA++RK W+R F+PG + DH   +I+Y DF+N
Sbjct: 722  RDLDRHLKEFHTMQDNEAELIELAFSKKKADERKEWLRQFKPGTFLDHSVEKISYTDFIN 781

Query: 299  KELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHG 358
            KELILFS AD  RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG
Sbjct: 782  KELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHG 841

Query: 359  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHE 418
            + SL  TI+G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH 
Sbjct: 842  DVSLQQTIVGLAQTFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRVFHA 901

Query: 419  NDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL 478
            +D+ LL Y  +DG++IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+
Sbjct: 902  SDEPLLTYNVDDGKTIEPEIYMPVVPMILINGADGIGTGWSSSIPNYNPEDVVDNLKRLM 961

Query: 479  NDETMVPMDPWYRGFKGIIEKSAKEGG-YIVNGTVEEIDEQSFRITELPIRKWTQDYKQF 537
            + E + PM PW+RGF G  E +A  G  +  +G ++E  E+   ITELPIR WTQD+K  
Sbjct: 962  DGEEIKPMQPWFRGFTG--EVTAIGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKDK 1019

Query: 538  LESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTIST 596
            LE I       K P  I+D++       V   I+M  + +   ++EGL  KFKLT TI+T
Sbjct: 1020 LEDIIKAE---KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKSAVEEGLEDKFKLTKTIAT 1076

Query: 597  SNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILG 656
            +N+  FD EG+I KY   + IL+EFF +RL +YERRKQY L   ++ L  L N+ RF+  
Sbjct: 1077 TNLVAFDPEGRITKYATVDDILKEFFAVRLKFYERRKQYQLNEMQKELEKLSNQARFVQM 1136

Query: 657  VVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXX 716
            ++ GE+VVS +KK+ L++EL++KGF P PK   +A+   A                    
Sbjct: 1137 IIDGELVVSKKKKSVLVVELKEKGFKPFPKVADAAKAGEAEPAAEDEEDSEDIDDTNNLS 1196

Query: 717  XXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                     Y+YLL M+I +LT E V+
Sbjct: 1197 NA-------YDYLLGMAIWSLTQERVE 1216


>F0Y200_AURAN (tr|F0Y200) DNA topoisomerase 2 (Fragment) OS=Aureococcus
            anophagefferens GN=AURANDRAFT_22331 PE=3 SV=1
          Length = 1228

 Score =  732 bits (1889), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/773 (49%), Positives = 507/773 (65%), Gaps = 20/773 (2%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            A+  SG++D +L+W  FKQ + LK+  G+K  RL GI KL+DAN AGG     CTLILTE
Sbjct: 410  AIEKSGVVDRVLAWTKFKQDEQLKRKGGSKKTRLTGITKLDDANAAGGARGKDCTLILTE 469

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAKALA++GL VVGRD YGVFPL+GK LNVREAS+  IM NEE+QN+ KILGL+    
Sbjct: 470  GDSAKALAVSGLGVVGRDLYGVFPLKGKPLNVREASHAAIMKNEEVQNVVKILGLRFGVT 529

Query: 132  Y--SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            Y  +N+K+LRYGHLMIM DQDHDGSHIKGLLIN +H FWPSLL++P F+  F TPI++A 
Sbjct: 530  YDEANLKTLRYGHLMIMTDQDHDGSHIKGLLINCLHHFWPSLLQIPGFLRCFITPIVKAT 589

Query: 190  HSNGTKLS--FYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
             +  +K +  F+++PEYE+W+E  G    G  IKYYKGLGTST +E +EYF +L  H+ D
Sbjct: 590  PAAKSKPAEVFFTLPEYEAWKEARGG-LHGHAIKYYKGLGTSTAKEAKEYFGELDTHQLD 648

Query: 248  FVWEDDY--DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFS 305
            +   D+   +G  I+MAFSKK+ EDRK W+RN EPG + D+    ++Y DFVNKELILFS
Sbjct: 649  YATLDESAREGDLIDMAFSKKRVEDRKTWLRNLEPGTFVDYAVDAMSYGDFVNKELILFS 708

Query: 306  RADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLAST 365
             AD QRSIPSVVDGLKP QRK+LF  FK+KL KEIKV Q  GYVSEH+AYHHGE SL  T
Sbjct: 709  VADNQRSIPSVVDGLKPSQRKVLFACFKRKLKKEIKVAQLAGYVSEHAAYHHGEMSLTGT 768

Query: 366  IIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLE 425
            I+GMAQDFVGSNN+NLL P GQFGTR +GGKD ASSRYI+T+L  + R +FH +DD +L+
Sbjct: 769  IVGMAQDFVGSNNVNLLTPAGQFGTRIMGGKDAASSRYIFTKLEAVARKVFHPDDDFVLD 828

Query: 426  YLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLN-DETMV 484
            YL +DG+SIEP++Y+P++P  L NG++GIGTGW++ +PNY PR +I  +RR+++ D    
Sbjct: 829  YLEDDGQSIEPTYYVPVLPFALCNGADGIGTGWATSVPNYAPRALIGVLRRMIDADVGAA 888

Query: 485  PMDPWYRGFKG-IIEKSAKE-GGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT 542
             + P YRGF G I+ K  K  G + V G    +D+ +  + ELP   WT DYKQ+LE   
Sbjct: 889  DLAPHYRGFGGDIVAKGGKNAGAFAVLGRATRLDDVTVLVDELP---WTHDYKQWLEVQL 945

Query: 543  DGSPNVKDPLIEDFRQNGDDAMVDIEIRM-KLEKI--AMIMQEGLLKKFKLTTTISTSNM 599
             G    K   ++DF++N  D  V   + + K E +  A     GL KKFKL  +++TSNM
Sbjct: 946  SGDDKTK-AWVKDFKENHTDTRVSFTVTVTKGEDLDDAEAALGGLEKKFKLEGSLATSNM 1004

Query: 600  HLFDAEG-KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVV 658
            + FD  G  I KY+ P  +++ F+ +R+  Y +RK ++++     + +L NKVRF+L V+
Sbjct: 1005 NFFDDTGLVIDKYDAPFDVIKAFYKVRVATYAKRKAHLVKAKRARVSLLRNKVRFVLSVL 1064

Query: 659  SGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXX 718
            SG++VV NRK+A+LL +L   G+  +       +                          
Sbjct: 1065 SGDLVVQNRKRAELLAQLVDDGYDAVYNAAAKKKTPAKADDDGDASGSDGDDDGAGAAAG 1124

Query: 719  XXXKR--GDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
                +    Y+YLLSM I +LT+E V                  A P  ++W+
Sbjct: 1125 SSDAQLAKGYDYLLSMKIWSLTMERVDALRAELKDEDAELVALVAKPETAIWL 1177


>L2GVJ4_VAVCU (tr|L2GVJ4) DNA topoisomerase 2 OS=Vavraia culicis (isolate
            floridensis) GN=VCUG_00778 PE=3 SV=1
          Length = 1224

 Score =  732 bits (1889), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 379/754 (50%), Positives = 504/754 (66%), Gaps = 87/754 (11%)

Query: 20   DTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALA 79
            D +LS A  K SK LKKTDG+K+ ++ G+ KL DAN AG +NS KC+LILTEGDSAK LA
Sbjct: 374  DRVLSQALAKMSKQLKKTDGSKSSKITGVEKLSDANLAGTKNSHKCSLILTEGDSAKTLA 433

Query: 80   MAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKSLR 139
            ++GLSVVGRDHYGVFPLRGKLLNVREA++KQIM+NEE+ N+KKIL LQ +KEY++ +SLR
Sbjct: 434  ISGLSVVGRDHYGVFPLRGKLLNVREANHKQIMENEELNNLKKILALQHHKEYTSTESLR 493

Query: 140  YGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF---------- 189
            YGH++IM DQDHDGSHIKGL+INF   F+PSLL++  F+ EF TPI+R            
Sbjct: 494  YGHVIIMTDQDHDGSHIKGLIINFFDHFFPSLLRIEGFLKEFITPIVRVTKKKRSRTQND 553

Query: 190  -------------------HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTST 230
                               HS GT + F+++PEYE W+ N   +   W +KYYKGLGTST
Sbjct: 554  NPEDDSDVQEVPRNSTRTDHSVGTVIDFFTIPEYEDWK-NSTPDVKNWSVKYYKGLGTST 612

Query: 231  PQEGREYFRDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASR 290
             ++ ++YF +L KH K F      D S I++AF+KKKA+DRK+W++N  PG + DH   +
Sbjct: 613  SKDAKQYFSNLDKHIKSFTLLTTEDKSLIDLAFNKKKADDRKLWLKNCVPGTFLDHSVHK 672

Query: 291  INYKDFVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVS 350
            I  KDF+NKELILFS AD  RSIPS+VDG KPGQRK+++C FK+ L  EIKV Q +GYV+
Sbjct: 673  IPIKDFINKELILFSMADNVRSIPSMVDGFKPGQRKVMYCCFKRNLKSEIKVAQLVGYVA 732

Query: 351  EHSAYHHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNP 410
            EHSAYHHGE SL  TII +A DFVGSNN+NLL+P GQFGTR  GGKD AS+RYI+T L  
Sbjct: 733  EHSAYHHGEMSLQQTIIKLAHDFVGSNNVNLLEPAGQFGTRLQGGKDAASARYIFTNLAN 792

Query: 411  ITRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDI 470
            ITR +F E+DD LL Y+ ED   IEP++Y+PI+P+VLVNG++GIGTGW + IPNY+  ++
Sbjct: 793  ITRKIFVESDDALLNYIIEDNLKIEPAFYVPIVPMVLVNGADGIGTGWLTKIPNYDLLEL 852

Query: 471  IANVRRLLNDETMVPMDPWYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIR 528
            I N++ LL+ + M  M P+YRGFKG IE     GG  Y ++G +  ++E+S  ITELP++
Sbjct: 853  IDNIKLLLDGQEMRTMVPFYRGFKGEIEDL---GGKKYRISG-IYGVEEESLTITELPVK 908

Query: 529  KWTQDYKQFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKF 588
             WTQ YK+FLE        ++   +++FR+   +  V  E       +++ +   L KKF
Sbjct: 909  IWTQTYKEFLEK------KIEKGEVKEFREYHTERNVHFE-------VSVTVSGELEKKF 955

Query: 589  KLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLD 648
             L+T    +N   FD  GKIKKY++ E+IL+EF+ +RL++Y  RK+Y+L+  E  L  L+
Sbjct: 956  GLSTISIFNNFVCFDRHGKIKKYDSAEEILKEFYSIRLEFYNLRKEYLLKTLEEELRKLE 1015

Query: 649  NKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXX 708
            NKVRFI  VV+G +VVS RKKAD++ EL+QK +  +                        
Sbjct: 1016 NKVRFIREVVNGTLVVSKRKKADIIAELEQKEYHKID----------------------- 1052

Query: 709  XXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESV 742
                             Y+YLL+MSI +LTLE +
Sbjct: 1053 ---------------DTYDYLLNMSILSLTLEKI 1071


>B6K4K4_SCHJY (tr|B6K4K4) DNA topoisomerase 2 OS=Schizosaccharomyces japonicus
            (strain yFS275 / FY16936) GN=SJAG_03567 PE=3 SV=1
          Length = 1499

 Score =  732 bits (1889), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 362/727 (49%), Positives = 496/727 (68%), Gaps = 13/727 (1%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
            S I+      A  K  + + KTDG    R+ G+ KL DAN AG R S KCTLILTEGDSA
Sbjct: 448  SEIIAVCSELAKAKADQQMSKTDGKSRSRITGLPKLSDANKAGTRESKKCTLILTEGDSA 507

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNV 135
            K L ++GL VVGRD+YGV+PLRGKLLNVREAS  QI++N+EIQ IKKILGL  NK+Y++ 
Sbjct: 508  KTLVVSGLGVVGRDYYGVYPLRGKLLNVREASYNQIINNKEIQAIKKILGLAHNKKYTST 567

Query: 136  KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK 195
              LRYGHLMIM DQDHDGSHIKGL+IN++ S +PSLL +  F++EF TPI+R        
Sbjct: 568  DGLRYGHLMIMTDQDHDGSHIKGLIINYLESTYPSLLHLEGFLIEFITPIVRCRKGREI- 626

Query: 196  LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYD 255
            +SF+++PE++ W+EN  NN  GW IKYYKGLGTS  ++ +EYF  L +H K F    D +
Sbjct: 627  ISFFTLPEFDYWKEN-NNNGRGWSIKYYKGLGTSDAKDMKEYFSALDRHIKQFHTIQDGE 685

Query: 256  GSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPS 315
               I+MAFSKKKA+ RK W+R + PG Y DH    I  K+F+N+ELILFS AD  RSIPS
Sbjct: 686  NDLIDMAFSKKKADVRKEWLRTYHPGLYIDHSQPVIEIKNFINQELILFSMADNIRSIPS 745

Query: 316  VVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVG 375
            VVDGLKPGQRK+++  FKK L  E KV Q  GY+SE +AYHHGE SL  TIIG+A +FVG
Sbjct: 746  VVDGLKPGQRKVIYGMFKKNLKNEAKVEQLAGYISEQTAYHHGETSLQQTIIGLAHNFVG 805

Query: 376  SNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIE 435
            SNNINLL P GQFG+R  GGKD A  RYI+T  + + R LF + DD +L YLN++G  +E
Sbjct: 806  SNNINLLLPKGQFGSRIEGGKDAAQPRYIFTMPSRMARLLFDKRDDPILNYLNDEGLWVE 865

Query: 436  PSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKG 495
            P +Y+PI+P++LVNG+EGIGTGWS++IPN+NP D++ N+R L+ +E + PM PWYRGFKG
Sbjct: 866  PDYYVPIVPMLLVNGAEGIGTGWSTFIPNFNPSDLVKNIRHLIKNEPLEPMHPWYRGFKG 925

Query: 496  IIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIED 555
             I++   +  Y V+G +E++ + +  ITELP+R WTQD K++LES+   + + +   I+D
Sbjct: 926  TIQQMTPD-RYKVSGIIEQVSDDTVDITELPVRLWTQDMKEYLESLM--AADKQGSFIKD 982

Query: 556  FRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPE 615
            + +   +  V   +++  E +A  + EGL  KFK+  T++TSNM  FD +G+I+KY++  
Sbjct: 983  YTEYHTEENVHFRVKLTKEGMATALAEGLENKFKVARTLATSNMVAFDPQGRIRKYDSAY 1042

Query: 616  QILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLME 675
             IL+EF+ +RL YY+RRK++++ + E +   + N+ RFI  ++ G +VV+ +K++ L+ E
Sbjct: 1043 DILKEFYEVRLRYYQRRKEHLVNDLETVYTKISNQARFIHMIIEGTLVVAKKKRSVLVQE 1102

Query: 676  LQQKGF--TPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMS 733
            L++KGF   P PKKG+ AE                             +  D+ YLL+M 
Sbjct: 1103 LREKGFKAIPKPKKGRLAE------IAAQETAANRDADDDAEEEDASPEADDFTYLLNMP 1156

Query: 734  IGTLTLE 740
            + +LT E
Sbjct: 1157 VYSLTYE 1163


>B8M038_TALSN (tr|B8M038) DNA topoisomerase 2 OS=Talaromyces stipitatus (strain
            ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
            GN=TSTA_083670 PE=3 SV=1
          Length = 1678

 Score =  731 bits (1888), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/813 (46%), Positives = 521/813 (64%), Gaps = 21/813 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VLKTEVMTNILHFAEKKADQILKKTDGGRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASIDQISKNAEIQNIKSFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+   +PSLLK+P F++EF TPI++ +   
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPEFLIEFITPIVKVWKGD 683

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE W+E    + T W+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 684  PKNPTKSKSFFTMPEYEQWKEEHKYDRT-WQHKYYKGLGTSTTEDAQIYFRDLDRHLKEF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R ++PG + DH   +I Y DF+NKELILFS AD
Sbjct: 743  HTMQDHEAQLIDLAFSKKKADERKEWLRQYKPGTFLDHSTKQITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 803  NQRSIPSVVDGLKPGQRKVLYTCFKRNVKKDMKVVELAGHVSGMTAYQHGDTSLQQTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH+ D+ LL Y  
Sbjct: 863  LAQTFVGSNNLNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFHQADEPLLTYNE 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++PL+L+NG++GIGTGWSS IPNYNP +++AN++R+++ E   PM P
Sbjct: 923  DDGEKIEPELYVPVVPLILINGADGIGTGWSSSIPNYNPEEVVANLKRMMDGEEPEPMQP 982

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG + +   +  Y  +G ++E+ ++   ITELPIR WTQD+K  LE I       
Sbjct: 983  WFRGFKGEVTQQGPD-RYKFSGLIKEVSDKEVEITELPIRTWTQDFKDKLEDIIKAE--- 1038

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   + EGL +KFKL+ TI+TSN+  FD EG+
Sbjct: 1039 KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKAAVSEGLEEKFKLSRTIATSNLVAFDPEGR 1098

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY     IL+EF+ +RL YYERRKQ+ L   ++ L    N+ RF+  ++ G++V+S +
Sbjct: 1099 ITKYATVSDILKEFYAVRLKYYERRKQHQLSELQKELDKFTNQARFVQMIIDGKLVISKK 1158

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KK  L+ EL++KGF P PK        V+ A                           Y+
Sbjct: 1159 KKPVLIAELKEKGFKPFPK--------VSEAVKAGETEQVVEEDESSEEANVEVASNAYD 1210

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL M+I +LT E V+                     + +W             Q  +E 
Sbjct: 1211 YLLGMAIWSLTQERVEKLLRQIGEKETEIDELIKLSKEDIWRRDLDDFINEWRFQLEEEQ 1270

Query: 788  EDEKKRISQASKRTSTRDLGTKAAKKPPQPRKN 820
              E+K ++   +R S++ L T A+K P + RKN
Sbjct: 1271 RRERK-VAGMGRRQSSK-LMTAASKGPGRKRKN 1301


>Q6PUA3_TETTH (tr|Q6PUA3) DNA topoisomerase 2 OS=Tetrahymena thermophila GN=TOP2B
            PE=2 SV=1
          Length = 1662

 Score =  731 bits (1887), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/754 (48%), Positives = 499/754 (66%), Gaps = 7/754 (0%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQ-RLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            S I++ +L  A  K+   + KT   K Q RL G+ KLEDANDAG RN++ CTLI+TEGDS
Sbjct: 378  SNIINHILLQARAKEQAKMAKTLSAKKQSRLLGVPKLEDANDAGTRNAESCTLIITEGDS 437

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAM+G+ VVGRD +GVFPL+GK+LNVR++++KQI +N EIQNI K++G++ N  Y N
Sbjct: 438  AKALAMSGIEVVGRDKFGVFPLKGKMLNVRDSTSKQITENLEIQNIIKVMGMKLNTNYDN 497

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
            VKSLRYG +MIMADQDHDGSHIKGL INFI +FWPSL ++  F+ EF TPI++    N +
Sbjct: 498  VKSLRYGSIMIMADQDHDGSHIKGLFINFIQNFWPSLFQMDGFLKEFITPIVKVRKGNQS 557

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             +SF+S+ +++ W+    N    WKIKYYKGLGTST QE +EYF ++ KH   F +    
Sbjct: 558  -ISFFSIQDFKRWKSTCPNQHL-WKIKYYKGLGTSTDQEAQEYFGNINKHVISFKYNGKD 615

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            D  AI++AF+KK+AEDRK W+  ++P    DH    + YKDFVNKELI FS +D  RSIP
Sbjct: 616  DEDAIDLAFNKKRAEDRKKWLVKYDPEENVDHSQKHLTYKDFVNKELINFSNSDNARSIP 675

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S+ DGLKPGQRKILF  FK+ L  EIKV Q  GYV+EHSAYHHGEQSL STI+GMAQ FV
Sbjct: 676  SLCDGLKPGQRKILFACFKRNLKNEIKVAQLSGYVAEHSAYHHGEQSLESTIVGMAQSFV 735

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            G+NNIN L P GQFG+RN+GGK+ AS+RYI+T LN ITRC+F E DD +L YL ++G+ +
Sbjct: 736  GTNNINYLMPIGQFGSRNMGGKEAASARYIHTCLNKITRCVFPEPDDHILYYLEDEGQQV 795

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP +Y+PIIP  L+NG++GIGTGWS+ IP YNPR+++ ++ + +       + PWY+GF 
Sbjct: 796  EPIYYLPIIPTALLNGADGIGTGWSTSIPCYNPRELVDSIEKRMMGVPFTDLLPWYKGFT 855

Query: 495  GIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIE 554
            G I  + K     V+G    ++E +  ITELPI+KW +DYK FLE   + + + KDP IE
Sbjct: 856  GEISNNEK-SQITVSGKYHLVNETTIEITELPIKKWIRDYKNFLEEKLESTKD-KDPEIE 913

Query: 555  DFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENP 614
            D ++      V   ++M  +++  + +EG+ K FKL +TI T+NM LF+ EGK+ +Y N 
Sbjct: 914  DIKEYHAGNRVHFVVKMSEKQMEKVQREGIDKYFKLQSTIPTTNMVLFNHEGKLTRYANI 973

Query: 615  EQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLM 674
             +I+EEF+ +RL+ Y+RRK+Y++   ER L +L NK RFIL V++  I V N K+ DL+ 
Sbjct: 974  CEIMEEFYEVRLNAYKRRKEYLVSKIERDLEILSNKKRFILAVINESIRVRNAKRKDLIK 1033

Query: 675  ELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSI 734
            EL  +G+  M    K    ++                          K  +Y YLLS+ +
Sbjct: 1034 ELSVQGYVQMKDMPKIKSSKLTSQLEQEQNQDSNEENFETNPNEINAK--EYNYLLSLPM 1091

Query: 735  GTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
             +LT E V+                 AT    +W
Sbjct: 1092 WSLTYEKVEEIKQEQKNKQDELDKLVATEVIDIW 1125


>I7MA91_TETTS (tr|I7MA91) DNA topoisomerase 2 OS=Tetrahymena thermophila (strain
            SB210) GN=TTHERM_00456750 PE=3 SV=1
          Length = 1680

 Score =  731 bits (1887), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/754 (48%), Positives = 499/754 (66%), Gaps = 7/754 (0%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQ-RLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            S I++ +L  A  K+   + KT   K Q RL G+ KLEDANDAG RN++ CTLI+TEGDS
Sbjct: 396  SNIINHILLQARAKEQAKMAKTLSAKKQSRLLGVPKLEDANDAGTRNAESCTLIITEGDS 455

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAM+G+ VVGRD +GVFPL+GK+LNVR++++KQI +N EIQNI K++G++ N  Y N
Sbjct: 456  AKALAMSGIEVVGRDKFGVFPLKGKMLNVRDSTSKQITENLEIQNIIKVMGMKLNTNYDN 515

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
            VKSLRYG +MIMADQDHDGSHIKGL INFI +FWPSL ++  F+ EF TPI++    N +
Sbjct: 516  VKSLRYGSIMIMADQDHDGSHIKGLFINFIQNFWPSLFQMDGFLKEFITPIVKVRKGNQS 575

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             +SF+S+ +++ W+    N    WKIKYYKGLGTST QE +EYF ++ KH   F +    
Sbjct: 576  -ISFFSIQDFKRWKSTCPNQHL-WKIKYYKGLGTSTDQEAQEYFGNINKHVISFKYNGKD 633

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            D  AI++AF+KK+AEDRK W+  ++P    DH    + YKDFVNKELI FS +D  RSIP
Sbjct: 634  DEDAIDLAFNKKRAEDRKKWLVKYDPEENVDHSQKHLTYKDFVNKELINFSNSDNARSIP 693

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            S+ DGLKPGQRKILF  FK+ L  EIKV Q  GYV+EHSAYHHGEQSL STI+GMAQ FV
Sbjct: 694  SLCDGLKPGQRKILFACFKRNLKNEIKVAQLSGYVAEHSAYHHGEQSLESTIVGMAQSFV 753

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            G+NNIN L P GQFG+RN+GGK+ AS+RYI+T LN ITRC+F E DD +L YL ++G+ +
Sbjct: 754  GTNNINYLMPIGQFGSRNMGGKEAASARYIHTCLNKITRCVFPEPDDHILYYLEDEGQQV 813

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP +Y+PIIP  L+NG++GIGTGWS+ IP YNPR+++ ++ + +       + PWY+GF 
Sbjct: 814  EPIYYLPIIPTALLNGADGIGTGWSTSIPCYNPRELVDSIEKRMMGVPFTDLLPWYKGFT 873

Query: 495  GIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIE 554
            G I  + K     V+G    ++E +  ITELPI+KW +DYK FLE   + + + KDP IE
Sbjct: 874  GEISNNEK-SQITVSGKYHLVNETTIEITELPIKKWIRDYKNFLEEKLESTKD-KDPEIE 931

Query: 555  DFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENP 614
            D ++      V   ++M  +++  + +EG+ K FKL +TI T+NM LF+ EGK+ +Y N 
Sbjct: 932  DIKEYHAGNRVHFVVKMSEKQMEKVQREGIDKYFKLQSTIPTTNMVLFNHEGKLTRYANI 991

Query: 615  EQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLM 674
             +I+EEF+ +RL+ Y+RRK+Y++   ER L +L NK RFIL V++  I V N K+ DL+ 
Sbjct: 992  CEIMEEFYEVRLNAYKRRKEYLVSKIERDLEILSNKKRFILAVINESIRVRNAKRKDLIK 1051

Query: 675  ELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSI 734
            EL  +G+  M    K    ++                          K  +Y YLLS+ +
Sbjct: 1052 ELSVQGYVQMKDMPKIKSSKLTSQLEQEQNQDSNEENFETNPNEINAK--EYNYLLSLPM 1109

Query: 735  GTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
             +LT E V+                 AT    +W
Sbjct: 1110 WSLTYEKVEEIKQEQKNKQDELDKLVATEVIDIW 1143


>F2S2F0_TRIT1 (tr|F2S2F0) DNA topoisomerase 2 OS=Trichophyton tonsurans (strain CBS
            112818) GN=TESG_05150 PE=3 SV=1
          Length = 1678

 Score =  730 bits (1885), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/736 (50%), Positives = 494/736 (67%), Gaps = 21/736 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  N
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGN 683

Query: 193  G-----TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                  TK SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K 
Sbjct: 684  PKNPTHTK-SFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQ 741

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F    D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS A
Sbjct: 742  FHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMA 801

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+
Sbjct: 802  DNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIV 861

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL   
Sbjct: 862  GLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNN 921

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM 
Sbjct: 922  IDDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMK 981

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PW+RGFKG +  S     Y  +G +++  +    ITELPI  WTQD+K  LE I      
Sbjct: 982  PWFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPICTWTQDFKDKLEEIIKAE-- 1037

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 1038 -KVPSFIKDYKDYNTHTDVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEG 1096

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 1097 RITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISK 1156

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KKA L+ ELQ+KGF P PK   + EP  AG                            Y
Sbjct: 1157 KKKAVLIQELQEKGFKPFPKVVGTPEPGEAGDVEEEEDEEEETTTAAASSDA-------Y 1209

Query: 727  EYLLSMSIGTLTLESV 742
            +YLLSM + +LT E V
Sbjct: 1210 DYLLSMPLWSLTQERV 1225


>B3LBF9_PLAKH (tr|B3LBF9) DNA topoisomerase 2 OS=Plasmodium knowlesi (strain H)
            GN=PKH_131580 PE=3 SV=1
          Length = 1506

 Score =  729 bits (1883), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 381/763 (49%), Positives = 507/763 (66%), Gaps = 16/763 (2%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTL 67
             V  S IL  +L WA  K   +L+K          +R+ GI KLEDANDAG ++S  CTL
Sbjct: 436  GVLKSSILSNILLWAQAKAQVELRKKMKAGSSKARERIIGIPKLEDANDAGSKHSQDCTL 495

Query: 68   ILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ 127
            ILTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI KI+GL 
Sbjct: 496  ILTEGDSAKTSCLAGLSIVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFKIMGLD 555

Query: 128  -QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPII 186
              +K   ++K LRYG LMIM DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI+
Sbjct: 556  ITDKNKEDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIV 615

Query: 187  RAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
            +    N  + SF+++ EYE W+E+   N  GWKIKYYKGLGTST +E ++YF D+  H+ 
Sbjct: 616  KVQKGN-QEHSFFTIAEYEEWKES--TNLVGWKIKYYKGLGTSTDKEFKQYFSDIKNHKI 672

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
             F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR
Sbjct: 673  MFLWTGDRDGDSIDMAFSKKRIEDRKIWLQNFVIGSYVDHKEKDLSYYDFVNKELIYYSR 732

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
             D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TI
Sbjct: 733  YDTERSIPNIMDGWKPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTI 792

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            I MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR +F+E DD +L+Y
Sbjct: 793  INMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASCTRSIFNEYDDPILKY 852

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            LNE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N++R +N E ++PM
Sbjct: 853  LNEEGQKIEPKYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIENIKRYINKEPLIPM 912

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PWY+ FKG IE + K G   + G + +ID+++  I ELPI+KWTQDYK+FLE +     
Sbjct: 913  IPWYKDFKGRIESNGKTGFETI-GIIRKIDDETLEINELPIKKWTQDYKEFLEELL---T 968

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
            + K+ LI D+  N     +   I+M   K+    +EGL K FKL +T++T+NM LFD   
Sbjct: 969  DEKNQLILDYIDNSSHEEICFTIKMDPAKLRKAEEEGLEKVFKLKSTLTTTNMTLFDYNL 1028

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            K++KY     IL+EF   RL+ YE RK Y++   E+   ++ NK +FIL +V+ E+VV+ 
Sbjct: 1029 KLQKYATELDILKEFCFQRLNAYENRKSYLIAKLEKEKKIISNKSKFILAIVNNELVVNK 1088

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KK  L+ EL +KG+ P     K  + ++                             DY
Sbjct: 1089 KKKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLEAADNPEDNEEIIAGISVK----DY 1144

Query: 727  EYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
            +YLLSM I +LTLE V+                     ++MW+
Sbjct: 1145 DYLLSMPIFSLTLEKVEELIAQHKEKEKELEILRNITVETMWL 1187


>Q0CSB2_ASPTN (tr|Q0CSB2) DNA topoisomerase 2 OS=Aspergillus terreus (strain NIH
            2624 / FGSC A1156) GN=ATEG_03422 PE=3 SV=1
          Length = 1732

 Score =  729 bits (1883), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 379/811 (46%), Positives = 517/811 (63%), Gaps = 26/811 (3%)

Query: 3    FYTYMLQMFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNS 62
            FY  +L+   + N      +L +A  K  + LKKTDG +  R+    KL DAN AG +  
Sbjct: 503  FYKKILKTEVMTN------ILHFAQQKADQMLKKTDGGRRSRMNN-PKLTDANKAGTKEG 555

Query: 63   DKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKK 122
              CTLILTEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK 
Sbjct: 556  HHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQIAKNQEIQNIKN 615

Query: 123  ILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFT 182
             +GLQ  KEY++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF 
Sbjct: 616  FIGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFI 675

Query: 183  TPIIRAFHS---NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYF 238
            TPI++ +     N TK  SF++MPEYE+W+E  G+   GW+ KYYKGLGTST ++ + YF
Sbjct: 676  TPIVKVWKGDPKNPTKQRSFFTMPEYEAWKEEHGHE-RGWEHKYYKGLGTSTTEDAQIYF 734

Query: 239  RDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVN 298
            RDL +H K+F    D +   IE+AFSKKKA++RK W+R F PG + DH   +I Y DF+N
Sbjct: 735  RDLDRHLKEFHTMQDNEVELIELAFSKKKADERKEWLRQFRPGTFLDHSVDKITYTDFIN 794

Query: 299  KELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHG 358
            KELILFS AD  RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG
Sbjct: 795  KELILFSMADNIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGTTAYQHG 854

Query: 359  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHE 418
            E SL  TI+G+AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH 
Sbjct: 855  EGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFHN 914

Query: 419  NDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL 478
            +DD LL Y  +DG  IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP DI+ N++R++
Sbjct: 915  HDDPLLTYNEDDGAKIEPEVYVPVVPMILINGADGIGTGWSSSIPNYNPEDIVENLKRMM 974

Query: 479  NDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFL 538
            + E + PM PW+RGF G +  +  +  +  +G ++E  ++   ITELPIR WTQD+K  L
Sbjct: 975  DGEPLKPMQPWFRGFTGEV-TAVGQDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKL 1033

Query: 539  ESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTS 597
            E I       K P  I+D++       V   I+M  + +   + EGL +KFKL+ T++T+
Sbjct: 1034 EDIIKAE---KTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMTTT 1090

Query: 598  NMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGV 657
            N+  FD EG+I KY + E I++EF+ +RL YYERRKQY L   ++ L  L N+ RF+  +
Sbjct: 1091 NLVAFDPEGRITKYASVEDIMKEFYAVRLKYYERRKQYQLNEMQKELDKLSNQARFVQMI 1150

Query: 658  VSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXX 717
            + G++V+S +KKA L+ EL++K F P PK        V  A                   
Sbjct: 1151 IDGKLVISKKKKAVLVAELKEKDFKPFPK--------VKEAVKAGETEPVVEEEEDSESG 1202

Query: 718  XXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXX 777
                    Y+YLL M I +LT E V+                     + +W         
Sbjct: 1203 DTEVLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWKRDLEDFIN 1262

Query: 778  XXXXQDGKEAEDEKKRISQASKRTSTRDLGT 808
                Q+ +EA  ++K ++   +RTS++ + T
Sbjct: 1263 EWRFQNDEEARRQRK-VANMGRRTSSKLMTT 1292


>D4DAV0_TRIVH (tr|D4DAV0) DNA topoisomerase 2 OS=Trichophyton verrucosum (strain
            HKI 0517) GN=TRV_04248 PE=3 SV=1
          Length = 1680

 Score =  729 bits (1882), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/735 (50%), Positives = 493/735 (67%), Gaps = 19/735 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 683

Query: 193  GT----KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 684  PKNPTHSKSFFTIPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 743  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 803  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 863  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 923  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKP 982

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 983  WFRGFKGEVSGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 1037

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 1038 KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 1097

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ GE+V+S +
Sbjct: 1098 ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGELVISKK 1157

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1158 KKAVLIQELQEKGFKPFPKVVGTPEPGEAGDVEEEEDEEEETTTAAVSSDA-------YD 1210

Query: 728  YLLSMSIGTLTLESV 742
            YLLSM + +LT E V
Sbjct: 1211 YLLSMPLWSLTQERV 1225


>H3HSC7_STRPU (tr|H3HSC7) DNA topoisomerase 2 OS=Strongylocentrotus purpuratus PE=3
            SV=1
          Length = 1632

 Score =  729 bits (1882), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 400/826 (48%), Positives = 527/826 (63%), Gaps = 33/826 (3%)

Query: 12   AVANSGILDTLLSWADFK-QSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A AN GI++ +LSW  FK QS+  KK   +K  +++G+ KL+DAN AGG+NS  CTLILT
Sbjct: 431  AAANCGIVENILSWMKFKAQSQLDKKCHTSKHSKIKGVPKLDDANSAGGKNSSVCTLILT 490

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL VVGRDHYGVFPLRGKLLNVREAS+KQIM+N EI NI KILGLQ   
Sbjct: 491  EGDSAKSLAVSGLGVVGRDHYGVFPLRGKLLNVREASHKQIMENAEINNIIKILGLQYKN 550

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
            +Y +   +KSLRYG LMIM DQD DGSHIKGLLINFIHS WP LL+  +F+ EF TPI++
Sbjct: 551  KYDSPESLKSLRYGRLMIMTDQDQDGSHIKGLLINFIHSNWPHLLQR-NFLEEFITPIVK 609

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A  +N T L FYS+PE+E W++   N  T WK+KYYKGLGTST +E +EYF D+ +HR  
Sbjct: 610  ASKANETTLPFYSLPEFEKWKDATDNWKT-WKVKYYKGLGTSTMKEAKEYFTDMERHRIP 668

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNF-EPGNYRDHVA-----------SRINYKD 295
            F +    D +AI +AFSKKK EDRKVW+  + E    R                +++Y +
Sbjct: 669  FEYTGPDDDAAIVLAFSKKKVEDRKVWLSEWLEERRSRKETGLGERYLYQKDTKKVSYNE 728

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKEL+LFS AD +RSIPS+VDGLKPGQRK+LF  FKK   KEIKV Q  G VSE SAY
Sbjct: 729  FINKELVLFSNADNERSIPSMVDGLKPGQRKVLFTCFKKYEKKEIKVAQMAGAVSELSAY 788

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQSL STII +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS+RYI+T+L+P+ R +
Sbjct: 789  HHGEQSLMSTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDAASARYIFTQLSPLARLV 848

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F  +DD LL Y+ +D + IEP +Y PIIP+VL+NGSEGIGTGWS+ I NY+ R+++ANVR
Sbjct: 849  FPHHDDPLLSYMYDDNQRIEPEFYAPIIPMVLINGSEGIGTGWSTRICNYDIREVVANVR 908

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            RLL  +  VPM P Y+ FKG IE+  +   + VNG +  +D+ S  ITELPIR WTQ+YK
Sbjct: 909  RLLAGDEPVPMLPSYKNFKGTIEE-FEPNRFAVNGEISVVDDNSVEITELPIRVWTQNYK 967

Query: 536  Q-FLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
            +  LE++  G+  VK P I D+++   D  V   ++M  +++    +EGL K FKL TT 
Sbjct: 968  ESVLENMVYGTDKVK-PSISDYKEYHTDTTVKFVVKMNEDRLLRGEEEGLHKMFKLQTTF 1026

Query: 595  STSN-MHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            S +N M L+D  G I++Y+N E+IL EFF LR++ Y +RK Y+    E     L+N+ RF
Sbjct: 1027 SQANLMVLYDRHGCIRRYDNVEEILREFFTLRMELYHKRKAYLEGILEAESSKLNNQARF 1086

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXX 713
            I+  + G++V+ N+ K+ ++ +L  +G+   P K          A               
Sbjct: 1087 IMEKIDGKVVIENKSKSSMISQLTSRGYDSDPVKAWKE------AQQKSVEEEEDSFDDA 1140

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXX 773
                       DY YLL MS+ +LT E                       +  +W     
Sbjct: 1141 ASDSSEAGSGPDYNYLLGMSLWSLTKEKKNDLLKQRDEKAAELSLLRRKTASMLWTDDLN 1200

Query: 774  XXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKKPPQPRK 819
                     + +E EDE   ++  S +  T+  G+K  K    PRK
Sbjct: 1201 AFMAELDRVEAQEREDESSGLTGVSSKM-TKGKGSKITK----PRK 1241


>C5FWK9_ARTOC (tr|C5FWK9) DNA topoisomerase 2 OS=Arthroderma otae (strain ATCC
            MYA-4605 / CBS 113480) GN=MCYG_07112 PE=3 SV=1
          Length = 1676

 Score =  729 bits (1882), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/737 (49%), Positives = 489/737 (66%), Gaps = 20/737 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 502  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 560

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 561  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 620

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 621  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 680

Query: 193  GT----KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL KH K F
Sbjct: 681  PKNPTHSKSFFTLPEYEEWKETHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDKHLKQF 739

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 740  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTEQITYSDFINKELILFSMAD 799

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV+DGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 800  NIRSIPSVIDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 859

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH  D+ LL    
Sbjct: 860  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHPADEPLLVNNT 919

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++AN++RL+  E +VPM P
Sbjct: 920  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVANLKRLMAGEELVPMKP 979

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI--TDGSP 546
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I   D  P
Sbjct: 980  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEITELPIRTWTQDFKDRLEEIIKADKVP 1037

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
            +     I+D++       V   I+M  + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 1038 S----FIKDYKDYNTHTNVHFIIQMDEKHMKKALEEGLEEKFKLIKPIATSNMVAFDAEG 1093

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL+ F+ +R+  YERRKQ++L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 1094 RITRYETPEDILQAFYAVRIKLYERRKQHLLSQLQSQLDKLSNQARFVQMIIDGKLVISK 1153

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KK  L+ EL+ K F P PK   +A+                                 Y
Sbjct: 1154 KKKTILIQELKDKAFKPFPKVADTAKSDEVDDEEGEEDEEEEGNSDAVLSSDA------Y 1207

Query: 727  EYLLSMSIGTLTLESVQ 743
            +YLLSM + +LT E V+
Sbjct: 1208 DYLLSMPLWSLTQERVE 1224


>Q8J2R9_TRIVO (tr|Q8J2R9) DNA topoisomerase 2 (Fragment) OS=Trichophyton violaceum
            GN=top2 PE=3 SV=1
          Length = 1094

 Score =  728 bits (1880), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/733 (50%), Positives = 493/733 (67%), Gaps = 19/733 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 376  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 434

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 435  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 494

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +   
Sbjct: 495  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 554

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N T   SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 555  PKNPTHTKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 613

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 614  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 673

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + ++IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 674  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRRDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 733

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 734  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 793

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 794  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMKP 853

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 854  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEITELPIRTWTQDFKDKLEEIIKAE--- 908

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 909  KVPSFIKDYKDYNTHTNVHFVIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 968

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 969  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1028

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1029 KKAVLIQELQEKGFKPFPKVVGTPEPGEAGDIEEEEDEEEETASAAVSSDA-------YD 1081

Query: 728  YLLSMSIGTLTLE 740
            YLLSM + +LT E
Sbjct: 1082 YLLSMPLWSLTHE 1094


>Q8X1U0_TALFL (tr|Q8X1U0) DNA topoisomerase 2 (Fragment) OS=Talaromyces flavus var.
            flavus GN=TOP 2 PE=3 SV=1
          Length = 1094

 Score =  728 bits (1879), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 373/735 (50%), Positives = 493/735 (67%), Gaps = 24/735 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + ++  +LS+A  K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 377  ILKTNVMSNILSFAAHKADQMLKKTDGGRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 435

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS +QI  N EIQNIK  +GLQ  KEY
Sbjct: 436  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFEQISKNAEIQNIKNFIGLQHKKEY 495

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPI++ +   
Sbjct: 496  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIVKVWKGD 555

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N T+  SF++MPEYE++RE   N    W+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 556  PKNPTRQHSFFTMPEYEAFREAHKNER--WEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 613

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D + + IE+AFSKKKA++RK W+R F PG Y DH  S+I Y DF+NKELILFS AD
Sbjct: 614  HTIQDNEAALIELAFSKKKADERKEWLRQFRPGTYLDHTLSKITYTDFINKELILFSMAD 673

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 674  NIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHGDASLQQTIVG 733

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ+FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R ++H +DD LL Y  
Sbjct: 734  LAQNFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRVYHSHDDPLLTYNE 793

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++P++LVNG++GIGTGWSS IPNYNP DI+ N+RR+++ E + PM P
Sbjct: 794  DDGEKIEPEIYMPVVPMILVNGTDGIGTGWSSSIPNYNPEDIVENLRRMMDGEEIKPMQP 853

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  Y  +G ++E  ++   ITELPIR WTQD+K  LE I     
Sbjct: 854  WFRGFNGEV---TDMGGDRYKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAE- 909

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D++       V   I+M  + +   + EGL +KFKLT +I+TSN+  FD E
Sbjct: 910  --KTPSFIKDYKDYNTHHKVHFVIQMDEKHMTAALSEGLEEKFKLTKSIATSNLVAFDPE 967

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EF+ +RL YYERRKQY L   +R L  L N+ RF+  ++ G++VVS
Sbjct: 968  GRITKYAGVDDILKEFYTIRLKYYERRKQYQLSEMQRELDRLSNQARFVQMIIDGDLVVS 1027

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
             +KK+ L+ EL++K F P PK        V  A                           
Sbjct: 1028 KKKKSALVAELKEKNFKPFPK--------VKDAVKAGEAEPALEDEEEEGAEDTEVLSNS 1079

Query: 726  YEYLLSMSIGTLTLE 740
            Y+YLL M+I +LT E
Sbjct: 1080 YDYLLGMAIWSLTHE 1094


>R7QHX8_CHOCR (tr|R7QHX8) Stackhouse genomic scaffold, scaffold_4 OS=Chondrus
            crispus GN=CHC_T00006305001 PE=4 SV=1
          Length = 1427

 Score =  728 bits (1879), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 381/742 (51%), Positives = 498/742 (67%), Gaps = 33/742 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V NS I++ +L++A FK+SK+L KTDG K  RL GI K  DAN AG R   KCTL+LTEG
Sbjct: 296  VMNSEIIENVLAFAKFKESKELAKTDGGKRVRLTGITKFYDANRAGTREGSKCTLVLTEG 355

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSA A A +GLSVVGRD+YGV+PLRGK+LNVREA +KQIMDN+EI N+KKILGLQ NK+Y
Sbjct: 356  DSAMATAFSGLSVVGRDYYGVYPLRGKMLNVREAKHKQIMDNKEINNLKKILGLQHNKKY 415

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
                +KSLRYGH++IMADQDHDGSHIKGL+INF   FWP LL++  F+ E  TPI++   
Sbjct: 416  CKETMKSLRYGHVLIMADQDHDGSHIKGLIINFFDHFWPGLLQIDGFLQELITPIVQCTK 475

Query: 191  SNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
                K+ F+++PEYE++ E+  + + GW+ KY+KGLGTST  + + YF DL  H  +F  
Sbjct: 476  GQKKKV-FFTIPEYETFCES--SESAGWEGKYFKGLGTSTSADAKSYFSDLPTHLHEFKH 532

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
                D   IE+AFSK++  DRK WI ++ PG Y  H    +NY +FVNKELILFS  D +
Sbjct: 533  TGVNDTDMIELAFSKQRVNDRKDWIASYAPGTYFHHGVDELNYANFVNKELILFSVYDNE 592

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFK-EIKVGQFIGYVSEHSAYHHGEQSLASTIIGM 369
            RSIP VVDG KP QRK++F  FK+KL K E+KV Q  GY+SE +AY HG+ SL STI+G+
Sbjct: 593  RSIPCVVDGFKPSQRKVMFGCFKRKLTKKELKVVQLAGYISEQTAYRHGDVSLQSTIVGL 652

Query: 370  AQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNE 429
             Q+FVGSNN+N L P GQFGTR  GGKD AS+RYI T+L PI R +F E DD +L YL +
Sbjct: 653  GQNFVGSNNLNFLVPAGQFGTRLTGGKDAASARYICTKLAPIARAMFPEADDAVLSYLVD 712

Query: 430  DGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPW 489
            + + IEP WY PIIP VLVNGSEGIGTGWSS +P YNPR++IAN+RRLL    M PM PW
Sbjct: 713  EDKVIEPKWYCPIIPTVLVNGSEGIGTGWSSSVPCYNPRELIANIRRLLAGNRMEPMMPW 772

Query: 490  YRGFKGIIEKSAKEGGYIVNGTVEEIDEQS-FRITELPIRKWTQDYKQFLESITDGSPNV 548
            YRGF G I        Y + GT+ +  E++ F++ ELPI+ WT  YK FLES+  GS   
Sbjct: 773  YRGFNGSIVPVQNSKSYDIYGTLRKSSEENVFKVEELPIKAWTSAYKDFLESVLIGSSEG 832

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIM--QEGLLKKFKLTTTISTSNMHLFDAEG 606
              P ++DF  N  +  V+  + M    ++  +   EG  KK KLT++++TSNM LF+ +G
Sbjct: 833  DSPFLKDFHDNSTENTVNFTL-MTTPAVSRTLSSSEG-YKKLKLTSSVTTSNMVLFNKDG 890

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +++KYENPE+IL+EFF  R   YE R+ ++L+  E+ LL LDNK RFIL V+  ++ V+ 
Sbjct: 891  RLRKYENPEEILQEFFETRYALYEDRRLHLLKELEQKLLCLDNKQRFILLVIDDKLKVAK 950

Query: 667  RKKADLLMELQQKGFTPM----PKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXK 722
            R+K  LL +L +  F P+     KKG  A+   + +                       +
Sbjct: 951  RRKDQLLADLVRLKFDPIHTGKAKKGSPADTPASDS----------------EENDNSPQ 994

Query: 723  RGD--YEYLLSMSIGTLTLESV 742
             GD  Y+YLLSM + +LT E V
Sbjct: 995  SGDKRYDYLLSMPLWSLTAERV 1016


>A1DP90_NEOFI (tr|A1DP90) DNA topoisomerase 2 OS=Neosartorya fischeri (strain ATCC
            1020 / DSM 3700 / FGSC A1164 / NRRL 181) GN=NFIA_059660
            PE=3 SV=1
          Length = 1735

 Score =  728 bits (1878), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 358/680 (52%), Positives = 483/680 (71%), Gaps = 13/680 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 503  ILKTEVMNNILHFAQAKADQLLKKTDGGRRTRMNN-PKLVDANKAGTKDGHHCTLILTEG 561

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS +QI  N+EIQNIK  LGLQ  KEY
Sbjct: 562  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFEQISKNQEIQNIKNFLGLQHKKEY 621

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPI++ +   
Sbjct: 622  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIVKVWKGD 681

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 682  PKNPTKQRSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 740

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+NKELILFS AD
Sbjct: 741  HTMQDHETELIELAFSKKKADERKEWLRQFKPGTFLDHSVEKITYTDFINKELILFSMAD 800

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 801  NQRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHGDASLQQTIVG 860

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG+D AS+RYIYT L+P  R +FH  DD LL Y  
Sbjct: 861  LAQTFVGSNNINCLEPSGNFGSRLQGGQDCASARYIYTRLSPFARRMFHAADDPLLTYNE 920

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWSS IPNYNP DI+ N++RL++ + + PM P
Sbjct: 921  DDGKKIEPEVYVPVVPLILINGADGIGTGWSSSIPNYNPEDIVDNLKRLMDSQPVKPMQP 980

Query: 489  WYRGFKGIIEKSAKEGG-YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            W+RGF G  E +A  G  +  +G ++E  ++   ITELPIR WTQD+K  LE I      
Sbjct: 981  WFRGFTG--EVTALGGDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEEIIKAE-- 1036

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M  + I   + EGL +KFKL+ TI+T+N+  FD EG
Sbjct: 1037 -KTPSFIKDYKDYNTHTKVHFVIQMDEKNIKSAVAEGLEEKFKLSKTIATTNLVAFDPEG 1095

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I KY + + IL+EF+ +RL +YERRKQY L   ++ L  L N+ RF+  ++ G++V+S 
Sbjct: 1096 RITKYASVDDILKEFYAVRLKFYERRKQYQLSELQKELDKLTNQARFVQMIIDGDLVISK 1155

Query: 667  RKKADLLMELQQKGFTPMPK 686
            +KK  L+ EL++ GF   PK
Sbjct: 1156 KKKPVLVAELKKHGFKAFPK 1175


>Q76C39_9EURO (tr|Q76C39) DNA topoisomerase 2 (Fragment) OS=Arthroderma persicolor
            GN=top2 PE=3 SV=1
          Length = 1086

 Score =  728 bits (1878), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 365/730 (50%), Positives = 490/730 (67%), Gaps = 20/730 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 372  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 430

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 431  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 490

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 491  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 550

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL KH K+F
Sbjct: 551  PKNPTHSKSFFTLPEYEEWKETHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDKHLKEF 609

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 610  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 669

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 670  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 729

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 730  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 789

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  E +VPM P
Sbjct: 790  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGEELVPMKP 849

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    I+ELPIR WTQD+K  LE I       
Sbjct: 850  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEISELPIRTWTQDFKDKLEEIIKAE--- 904

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 905  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 964

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RFI  ++ G++V+S +
Sbjct: 965  ITRYETPEDILRAFYAVRIKLYEKRKQHLLSELQTQLDKLSNQARFIQMIIDGKLVISKK 1024

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1025 KKALLIQELQEKGFKPFPKVADTPEPGEAGDIEEDEEEEETVTATLASDA--------YD 1076

Query: 728  YLLSMSIGTL 737
            YLLSM + +L
Sbjct: 1077 YLLSMPLWSL 1086


>E3X4B6_ANODA (tr|E3X4B6) DNA topoisomerase 2 OS=Anopheles darlingi GN=AND_13286
            PE=3 SV=1
          Length = 1530

 Score =  727 bits (1877), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/694 (52%), Positives = 489/694 (70%), Gaps = 22/694 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            AVA SGI++++L WA FK   DL KT G+K  +++GI KLEDANDAG RNS  CTLILTE
Sbjct: 404  AVAKSGIVESVLQWAKFKAQTDLAKTSGSKKSKIKGIPKLEDANDAGSRNSLNCTLILTE 463

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK LA++GL VVGRD YGVFPLRGKLLNVREA++KQI++N EI N+ KILGLQ  K+
Sbjct: 464  GDSAKTLAVSGLGVVGRDTYGVFPLRGKLLNVREATHKQILENAEINNLIKILGLQYKKK 523

Query: 132  Y---SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA 188
            Y    ++K+LRYG +MIM DQD DGSHIKGLLINFIH+ WP LL++P F+ EF TPI++A
Sbjct: 524  YLTTDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKA 582

Query: 189  FHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
               NGT+LSF+S+PE+E W+    N  T + IKYYKGLGTST +E +EYF+++ +HR  F
Sbjct: 583  TKKNGTELSFFSLPEFEEWKAETPNAHT-FNIKYYKGLGTSTSKEAKEYFQNMERHRILF 641

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIR-NFEPGNYRDHVASR-----------INYKDF 296
             +ED+ D  AI MAFSKK  + RK W+  + E   +R  V  +           I+YKDF
Sbjct: 642  RYEDNGDDDAIMMAFSKKAVDQRKDWLTAHMEECRHRKQVGLQERYLYTKTTKAISYKDF 701

Query: 297  VNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYH 356
            VN EL+LFS +D  RSIP ++DGLKPGQRK++F  FK+   +E+KV Q  G V+E SAYH
Sbjct: 702  VNLELVLFSNSDNVRSIPCMLDGLKPGQRKVMFTCFKRNDKREVKVAQLAGSVAEMSAYH 761

Query: 357  HGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLF 416
            HGEQSL STII +AQ+FVGSNNINLL P GQFGTR  GGKD AS RYI+T L+ +TR +F
Sbjct: 762  HGEQSLCSTIINLAQNFVGSNNINLLYPGGQFGTRLTGGKDSASPRYIFTMLSTLTRLIF 821

Query: 417  HENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRR 476
            H  DD LLEY  ED + IEP WY+PIIP++LVNG+EGIGTGWS+ IPN+NPRD+IAN+RR
Sbjct: 822  HPLDDPLLEYQYEDNQRIEPVWYLPIIPMLLVNGAEGIGTGWSTKIPNHNPRDVIANIRR 881

Query: 477  LLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ 536
            +LN E    ++PWY+ F+G++E S     Y+  G V  +D Q   I+ELPI  WTQ YK+
Sbjct: 882  MLNGEEPKVLNPWYKNFRGLVE-SVGHQKYLTVGNVALLDGQKIEISELPIGTWTQTYKE 940

Query: 537  -FLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTT 593
              LE +  GS   K  +I D+++   D  V   +     + A +  E  G  + FKLT++
Sbjct: 941  NVLEPLLHGSDKQK-AVISDYKEYNTDTTVRFVVSFLPGEYAKLYAEEGGFHRLFKLTSS 999

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ISTS+M+ FD +  +K+Y++   I ++F+ +RL+YY +R++Y+L   +     + +K RF
Sbjct: 1000 ISTSSMNAFDDKNYLKRYDHANSIFQDFYTIRLEYYGKRREYLLGMLQAEADSMSDKARF 1059

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKK 687
            I+   SG++ V N+K+  L+ E+ ++G+ P P K
Sbjct: 1060 IMEKCSGQLTVENKKRKALIEEMIKRGYRPDPIK 1093


>G0QS48_ICHMG (tr|G0QS48) DNA topoisomerase 2 OS=Ichthyophthirius multifiliis
            (strain G5) GN=IMG5_099230 PE=3 SV=1
          Length = 1481

 Score =  727 bits (1877), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 362/671 (53%), Positives = 480/671 (71%), Gaps = 5/671 (0%)

Query: 16   SGILDTLLSWADFKQSKDLKKT-DGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            +GIL+ +L     K+   +KK     K  RL GI KLEDANDAG R  D+CTL +TEGDS
Sbjct: 384  TGILENILVQIKAKEQAKMKKALSSNKQSRLLGIPKLEDANDAGTRLGDQCTLFVTEGDS 443

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AKALAM+G+ VVGRD +GVFPL+GK+LNVREAS KQI +N+EIQNI KI+GL+   +Y N
Sbjct: 444  AKALAMSGIEVVGRDKFGVFPLKGKMLNVREASVKQITENQEIQNIIKIMGLKLGAKYEN 503

Query: 135  VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGT 194
             KSLRYG + IMADQDHDGSHIKGL INFI +FWPSL ++  F+ EF TPI++      +
Sbjct: 504  TKSLRYGSIAIMADQDHDGSHIKGLFINFIQNFWPSLFEMKGFLKEFVTPIVKVRKGEQS 563

Query: 195  KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDY 254
             LSF+S+ +++ W+ +LG+N+  WK KYYKGLGTST  E REYF+++ KH   F + +D 
Sbjct: 564  -LSFFSLHDFKKWKNSLGDNSNQWKTKYYKGLGTSTDMEAREYFQNVEKHMISFTYLNDE 622

Query: 255  DGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIP 314
            D  +I++AF+KKKA+ RK W+  F   +  DH    + YKDFV+KELI FS +D  RSIP
Sbjct: 623  DEESIDLAFNKKKADARKEWLNAFNEDDNVDHTQKNLRYKDFVHKELINFSISDNARSIP 682

Query: 315  SVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFV 374
            ++ DGLK GQRKILF  FK+ L +EIKV Q  GYV+EHSAYHHGEQSLA TI GMAQ+FV
Sbjct: 683  NICDGLKTGQRKILFACFKRNLKQEIKVAQLSGYVAEHSAYHHGEQSLAQTITGMAQNFV 742

Query: 375  GSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSI 434
            GSNNINLL P GQFG+RN+GGK+ AS+RYI+T LN ITR +F +NDD +L+YL +DG  +
Sbjct: 743  GSNNINLLMPIGQFGSRNMGGKEAASARYIHTNLNKITRVIFPQNDDYILQYLEDDGYLV 802

Query: 435  EPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFK 494
            EP +Y+PIIP+VLVNG+EGIGTGWS+ IP YNPR+I+ ++++ +  E    + PWY+G++
Sbjct: 803  EPKYYLPIIPMVLVNGAEGIGTGWSTSIPQYNPREIVQSIQKRMEGENWEQLIPWYKGYQ 862

Query: 495  GIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIE 554
            G IE + K G Y V G    I E    ITELPI+KWT+D+K FLE   + S + K+  IE
Sbjct: 863  GEIENNDK-GQYNVKGRASIIGENLVEITELPIKKWTRDFKNFLEEKMESSKD-KEQEIE 920

Query: 555  DFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKK-FKLTTTISTSNMHLFDAEGKIKKYEN 613
            D ++      V  E++M    +  I++EG L K FKL ++ISTSNM LF+ EGKI KY N
Sbjct: 921  DIKEYHTGNNVRFEVKMVNGMLDKILKEGGLDKYFKLVSSISTSNMVLFNHEGKIVKYNN 980

Query: 614  PEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLL 673
             ++I+E+F+ LRLD Y++RK+++     R L +L+NK RFIL V+  ++ + N KK ++L
Sbjct: 981  IQEIMEDFYKLRLDLYKQRKEFLASKILRDLEILNNKKRFILSVIEEKLDIKNTKKKEIL 1040

Query: 674  MELQQKGFTPM 684
             +L    F  M
Sbjct: 1041 KQLVALRFVEM 1051


>B7G2L6_PHATC (tr|B7G2L6) DNA topoisomerase 2 (Fragment) OS=Phaeodactylum
            tricornutum (strain CCAP 1055/1) GN=PHATRDRAFT_52174 PE=3
            SV=1
          Length = 1143

 Score =  727 bits (1876), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 375/768 (48%), Positives = 502/768 (65%), Gaps = 29/768 (3%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
            S I++ +L+++ F+  + LK   G K  +L GI KL+DAN AG   S  CTLI+TEGDSA
Sbjct: 387  SAIVENVLAFSQFRDRQALKNKSGKKKAKLTGIDKLDDANFAGTAKSKDCTLIITEGDSA 446

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY--S 133
            K+LAMAGLSV+GRD+YGVFPLRGK LNVR+A  K +  NEEI+N+ +I+GL+    Y  +
Sbjct: 447  KSLAMAGLSVIGRDYYGVFPLRGKPLNVRDAPIKAVTSNEEIKNVVEIMGLKFQTVYDET 506

Query: 134  NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNG 193
            N+K LRYGHLMIMADQD+DGSHIKGL+INFIH+FWPSLL +P F+ +F TPI++   S G
Sbjct: 507  NIKQLRYGHLMIMADQDNDGSHIKGLIINFIHNFWPSLLDIPGFLQQFITPIVKV--SKG 564

Query: 194  TK-LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             K  SF+++PEYE+W E+ G N  GWKIKYYKGLGTST  E +EYF +L  H    V  D
Sbjct: 565  QKSQSFFNLPEYENWLESTGKNGHGWKIKYYKGLGTSTSAEAKEYFSNLDLHE---VLPD 621

Query: 253  DYDGS--AIEMAFSKKKAEDRKVWIRNFEPG---NYRDHVASRINYKDFVNKELILFSRA 307
                    I+M F K + EDRK W+         NY +     + Y +F+N+E ILFS++
Sbjct: 622  TVQSGNDLIDMVFRKNRVEDRKQWLNAIAKDTFLNYSEVSKEGVMYSEFINREYILFSKS 681

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D +RSIP ++DG KP QRKILF  FK+KL  EIKV Q  GYV+EHSAYHHGE SL +TI+
Sbjct: 682  DNERSIPHLLDGFKPSQRKILFACFKRKLKGEIKVAQLTGYVAEHSAYHHGEASLQATIV 741

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
             MAQ+F GSNNINLL P+GQFGTR +GGKD AS+RYI+T+L PITR +FH +DD+LL Y+
Sbjct: 742  NMAQNFCGSNNINLLTPSGQFGTRRMGGKDAASARYIFTKLEPITRAIFHPDDDELLSYI 801

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
            N+DG ++EP +Y+P+IP++LVNG++GIGTGWS+ + NYNPR+I+ N+RR +  E  V M 
Sbjct: 802  NDDGVTVEPEYYVPVIPMILVNGADGIGTGWSTSVNNYNPREIVRNLRRKIAGEDFVAMA 861

Query: 488  PWYRGFKGII----EKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITD 543
            P+Y GFKG I      S + G Y + G VE I++ +  I+ELP+RKWTQDYK FLE +  
Sbjct: 862  PFYSGFKGEIIPVDSNSRRSGSYDMLGKVERINDTTIIISELPVRKWTQDYKAFLEIMLT 921

Query: 544  GSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHL 601
            G    K P I+DF +N  +  V   I  + EKI    +E  GL+ KFKLT ++STSNM L
Sbjct: 922  GDGKKKLPEIKDFTENHTETTVSFTIIAEKEKIDEFEKEKAGLMGKFKLTGSLSTSNMTL 981

Query: 602  FDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGE 661
            FD  G+I ++E+PE I+  F+ +RLD+Y++RK+ +++  +     L NK RF+  V   E
Sbjct: 982  FDERGRITRFEDPESIMNAFYDIRLDFYDKRKRLLVKKLKEEQRKLSNKARFVEEVCRVE 1041

Query: 662  IVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXX 721
            +VV+NRK+ D+L EL+ +G+       +S E   +                         
Sbjct: 1042 LVVNNRKRQDILHELRNRGYETFGADARSKETSDSDGEEDSINESQSDAELA-------- 1093

Query: 722  KRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
             RG YEYLL M I +LT E  +                  T    +W+
Sbjct: 1094 -RG-YEYLLGMKIWSLTFEKAEELRRKLGEKTTELNALQGTSPSELWL 1139


>Q8J2S0_9EURO (tr|Q8J2S0) DNA topoisomerase 2 (Fragment) OS=Trichophyton
            interdigitale GN=top2 PE=3 SV=1
          Length = 1093

 Score =  726 bits (1875), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/732 (50%), Positives = 493/732 (67%), Gaps = 21/732 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 376  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 434

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 435  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 494

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  N
Sbjct: 495  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGN 554

Query: 193  -----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                  TK SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K 
Sbjct: 555  PKNPTHTK-SFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQ 612

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F    D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS A
Sbjct: 613  FHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMA 672

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+
Sbjct: 673  DNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIV 732

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL   
Sbjct: 733  GLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNN 792

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM 
Sbjct: 793  IDDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMK 852

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PW+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I      
Sbjct: 853  PWFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE-- 908

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 909  -KVPSFIKDYKDYNTHTDVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEG 967

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 968  RITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISK 1027

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KKA L+ ELQ+KGF P PK   + EP  AG                            Y
Sbjct: 1028 KKKAVLIQELQEKGFKPFPKVVGTPEPGEAGDVEEEEDEEEETTTAAASSDA-------Y 1080

Query: 727  EYLLSMSIGTLT 738
            +YLLSM + +LT
Sbjct: 1081 DYLLSMPLWSLT 1092


>Q8J2S1_TRIRU (tr|Q8J2S1) DNA topoisomerase 2 (Fragment) OS=Trichophyton rubrum
            GN=top2 PE=3 SV=1
          Length = 1097

 Score =  726 bits (1875), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/735 (49%), Positives = 494/735 (67%), Gaps = 19/735 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 377  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 435

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 436  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 495

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQD+DGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +   
Sbjct: 496  TDTRGLRYGHLMIMTDQDYDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 555

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N T   SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 556  PKNPTHTKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 614

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 615  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 674

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + ++IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 675  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRRDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 734

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 735  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 794

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 795  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMKP 854

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 855  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEITELPIRTWTQDFKDKLEEIIKAE--- 909

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 910  KVPSFIKDYKDYNTHTNVHFVIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 969

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 970  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1029

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1030 KKAVLIQELQEKGFKPFPKVVGTPEPGEAGDIEEEEDEEEETASAAVSSDA-------YD 1082

Query: 728  YLLSMSIGTLTLESV 742
            YLLSM + +LT E V
Sbjct: 1083 YLLSMPLWSLTHERV 1097


>D4AZ93_ARTBC (tr|D4AZ93) DNA topoisomerase 2 OS=Arthroderma benhamiae (strain ATCC
            MYA-4681 / CBS 112371) GN=ARB_01513 PE=3 SV=1
          Length = 1680

 Score =  726 bits (1875), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/735 (49%), Positives = 492/735 (66%), Gaps = 19/735 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 505  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 624  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 683

Query: 193  GT----KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 684  PKNPTHSKSFFTIPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 743  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 803  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH  D+ LL    
Sbjct: 863  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHPADEPLLVNNV 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 923  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKP 982

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 983  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 1037

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 1038 KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 1097

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 1098 ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1157

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1158 KKAVLIQELQEKGFKPFPKVVGTPEPGEAGDVEEEEDEEEETTTAAVSSDA-------YD 1210

Query: 728  YLLSMSIGTLTLESV 742
            YLLSM + +LT E V
Sbjct: 1211 YLLSMPLWSLTQERV 1225


>D8MBJ7_BLAHO (tr|D8MBJ7) DNA topoisomerase 2 OS=Blastocystis hominis
            GN=GSBLH_T00005036001 PE=3 SV=1
          Length = 1573

 Score =  726 bits (1874), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/756 (48%), Positives = 494/756 (65%), Gaps = 7/756 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V   GI+D +  ++ FK+ + LKK  G KT R   I KL+DAN AG R+S  CTLI+TEG
Sbjct: 414  VEKCGIVDAVSVFSRFKEDQMLKKQSGKKTARKLNIPKLDDANFAGTRHSKDCTLIITEG 473

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+L + GLS++GRD+YGVFPLRGK+LNVR+ S   ++ NEEI N+ +ILGL+ +  Y
Sbjct: 474  DSAKSLVVGGLSIIGRDYYGVFPLRGKMLNVRDVSRAAVIKNEEIHNLVQILGLKFDTVY 533

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +V SLRYG L+IMADQD+DGSHIKGL+INF   FWPSLLK+ +F+ +F TPI++A    
Sbjct: 534  DDVSSLRYGKLVIMADQDYDGSHIKGLVINFFQVFWPSLLKL-NFLQQFITPIVKATKGR 592

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             +   F+++ +Y++W +   N   G+ IKYYKGLGTSTPQEG+EYF +L +H   F    
Sbjct: 593  QS-FMFFTLQQYKNWLQT-HNEGKGYYIKYYKGLGTSTPQEGKEYFSNLSRHLVPFKSIT 650

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
            D + S ++M F KK+  +RK WI  ++PG+Y D+   ++ Y DF++KELI FSR D  RS
Sbjct: 651  DDESSHLDMLFRKKRVAERKEWINQYQPGDYIDYAVDKMAYSDFMDKELIQFSRYDNARS 710

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP VVDGLKP QRK+LF +FK+KL  EIKV QF GYVSEH+AYHHGEQSL  TIIGMAQD
Sbjct: 711  IPCVVDGLKPSQRKVLFGAFKRKLTSEIKVVQFSGYVSEHAAYHHGEQSLNDTIIGMAQD 770

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            FVGSNNINL  P GQFG+R LGGKD AS RYIYT L+PITR +F E+DD L  YL E+G+
Sbjct: 771  FVGSNNINLFVPAGQFGSRLLGGKDAASPRYIYTYLSPITRLIFKEDDDLLCNYLVEEGQ 830

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
            SIEP +Y+PIIP+VLVNG+EGIGTG+S+ IPNYNP +I   +   LN+E    + PW+RG
Sbjct: 831  SIEPEFYLPIIPMVLVNGAEGIGTGYSTKIPNYNPVEIANYIIAKLNNEKPPELHPWWRG 890

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G I K  K  GY++ G + ++D+ ++ ITELPI +WTQDYKQ L  +    P  K P+
Sbjct: 891  FTGDIYKRPK--GYLIRGRITKVDDLTYVITELPIGRWTQDYKQILTEMM--LPEKKAPV 946

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I DF++N  D  V   + +  E+   +  + L K FKL   I+TSN +LF + G+I  Y 
Sbjct: 947  IADFKENHTDTTVHFTVMLTPEQAQALQGQDLYKFFKLEAAITTSNFNLFSSTGQITHYA 1006

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            +P+ I++EFF  RL YY+ RK ++L  FE+ +  L N  RFIL VV G+++++NR + D+
Sbjct: 1007 SPQHIIDEFFEFRLPYYQERKDFLLAKFEKEIRRLSNMTRFILEVVEGKLIINNRPRKDI 1066

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L ++ + P+  + K    +                               Y YLLSM
Sbjct: 1067 MQDLVKRKYDPIYPEAKKTSSKSGDVEIAKQDEKEEGVDLDSADENLSKLLKGYNYLLSM 1126

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
             I +LT E V                   TP   +W
Sbjct: 1127 KIWSLTKELVDELKKNLETAQKKMQELQDTPPSQLW 1162


>Q76C38_9EURO (tr|Q76C38) DNA topoisomerase 2 (Fragment) OS=Trichophyton
            interdigitale GN=top2 PE=3 SV=1
          Length = 1089

 Score =  726 bits (1873), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 359/691 (51%), Positives = 482/691 (69%), Gaps = 14/691 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  N
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGN 552

Query: 193  -----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                  TK SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K 
Sbjct: 553  PKNPTHTK-SFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQ 610

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F    D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS A
Sbjct: 611  FHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMA 670

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+
Sbjct: 671  DNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIV 730

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL   
Sbjct: 731  GLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNN 790

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM 
Sbjct: 791  IDDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMK 850

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PW+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I      
Sbjct: 851  PWFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE-- 906

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 907  -KVPSFIKDYKDYNTHTDVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEG 965

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 966  RITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISK 1025

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAG 697
            +KKA L+ ELQ+KGF P PK   + EP  AG
Sbjct: 1026 KKKAVLIQELQEKGFKPFPKVVGTPEPGEAG 1056


>E4US63_ARTGP (tr|E4US63) DNA topoisomerase 2 OS=Arthroderma gypseum (strain ATCC
            MYA-4604 / CBS 118893) GN=MGYG_03483 PE=3 SV=1
          Length = 1672

 Score =  726 bits (1873), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 365/736 (49%), Positives = 493/736 (66%), Gaps = 20/736 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 503  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 561

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 562  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 621

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 622  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 681

Query: 193  GT----KLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 682  PKNPTHSKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQVYFQDLDRHLKQF 740

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 741  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSMDQITYTDFINKELILFSMAD 800

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 801  NIRSIPSVVDGLKPGQRKVLYTMFKRNVKKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 860

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 861  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLANNV 920

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  + +VPM P
Sbjct: 921  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGDELVPMKP 980

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    I+ELPIR WTQD+K  LE I       
Sbjct: 981  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEISELPIRTWTQDFKDKLEEIIKAE--- 1035

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 1036 KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKAVEEGLEEKFKLVKPIATSNMVAFDAEGR 1095

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 1096 ITRYETPEDILRAFYAVRIKLYEKRKQHLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1155

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KKA L+ ELQ+KGF P PK   + EP  AG                            Y+
Sbjct: 1156 KKALLIQELQEKGFKPFPKVVDTPEPGEAGDVEDEEDEEETATAALSSDA--------YD 1207

Query: 728  YLLSMSIGTLTLESVQ 743
            YLLSM + +LT E V+
Sbjct: 1208 YLLSMPLWSLTQERVE 1223


>J9HZI4_9SPIT (tr|J9HZI4) DNA topoisomerase 2 OS=Oxytricha trifallax
            GN=OXYTRI_06696 PE=3 SV=1
          Length = 1410

 Score =  725 bits (1871), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 366/675 (54%), Positives = 483/675 (71%), Gaps = 16/675 (2%)

Query: 16   SGILDTLLSWADFKQSKDLKKT--DGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGD 73
            SGI+++++S A  K+   L +    G K  +L GI KLEDANDAG +++  CT+ILTEGD
Sbjct: 390  SGIIESIVSVAKAKEEAKLVRNLNQGKKKSKLMGIPKLEDANDAGTKHARDCTIILTEGD 449

Query: 74   SAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY- 132
            SAK+LA+AG+ VVGRD +GVFPLRGK LNVREA +KQIMDN EIQN+ KI+GL+  K+Y 
Sbjct: 450  SAKSLALAGIEVVGRDKFGVFPLRGKFLNVREAGSKQIMDNPEIQNLIKIIGLKIGKKYE 509

Query: 133  --SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
              +++  LRYG LMIM DQDHDGSHIKGLLINFIH FWP+L++   F+ EF TPII+A  
Sbjct: 510  VDADLNDLRYGKLMIMTDQDHDGSHIKGLLINFIHFFWPTLMRNNGFVREFVTPIIKATK 569

Query: 191  SNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             N    SF+++PEYE W +  G N  GWKIKYYKGLGTS+ +E +EYF  +  H+ +F +
Sbjct: 570  GNEV-YSFFTIPEYEQWAD--GRNLKGWKIKYYKGLGTSSAKEAKEYFSAIDNHQIEFEY 626

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
             D+ D   I++AF+KK A+ RK W+  +    Y DH  + + YKDFVNKELILFS AD  
Sbjct: 627  VDNEDEEVIDLAFNKKLADKRKDWLTTYRTDLYVDHSQTHLRYKDFVNKELILFSVADCL 686

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIP++ DGLKPGQRKILFC FKKKL  EIKV Q +GYV E+SAYHHGEQSL  TII MA
Sbjct: 687  RSIPNLCDGLKPGQRKILFCVFKKKLKDEIKVAQLVGYVGENSAYHHGEQSLCQTIITMA 746

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q+FVGSNNINLL P GQFGTRN GGK+ AS RYI+T LNP+TR +F + DD +L YL E+
Sbjct: 747  QNFVGSNNINLLLPLGQFGTRNQGGKEAASPRYIFTNLNPVTRTIFPQEDDAVLNYLEEE 806

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G+SIEP +Y+PIIP+ LVNG+EGIGTGWS++IP +NP+DI+ N++R++  E    M PWY
Sbjct: 807  GQSIEPDYYLPIIPMCLVNGAEGIGTGWSTFIPCHNPKDIVDNLKRMMKGEPYQTMRPWY 866

Query: 491  RGFKGIIEK-SAKEGGYIVNGTVEEIDE-QSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            +G+ G IE     + GY+V G  E +D+  S  ITELPI KWT+DYK FLE + D    V
Sbjct: 867  KGYLGSIETLQGGKNGYLVRGNYEVLDDGMSLVITELPIGKWTRDYKTFLEELAD----V 922

Query: 549  KD-PLIEDFRQNGDDAMVDIEIRMKLEKIAMI-MQEGLLKKFKLTTTISTSNMHLFDAEG 606
            K+  ++++ R+   +  V   ++    K+  I  +EG+ KKFKL+TT+S++N  LFD +G
Sbjct: 923  KNGEIVDEIRELHTENRVHFIVKCNPGKLQDIEAKEGIEKKFKLSTTLSSANYVLFDYQG 982

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            KI+KY   E I+ EFF LR   Y RRK YIL    +    ++NK+RFIL +++ +I ++ 
Sbjct: 983  KIRKYAGEEYIVREFFGLREALYHRRKDYILARLRKEFETIENKMRFILAIINEDIKINR 1042

Query: 667  RKKADLLMELQQKGF 681
             KK  ++ +L++ GF
Sbjct: 1043 VKKKIIVAKLREMGF 1057


>Q76C43_9EURO (tr|Q76C43) DNA topoisomerase 2 (Fragment) OS=Arthroderma obtusum
            GN=top2 PE=3 SV=1
          Length = 1086

 Score =  725 bits (1871), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/691 (51%), Positives = 481/691 (69%), Gaps = 14/691 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 372  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 430

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 431  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 490

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 491  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 550

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 551  PKNPTHSKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 609

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 610  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 669

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 670  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 729

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R LFH++D+ LL    
Sbjct: 730  LAQTFVGSNNVNCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQSDEPLLVNNV 789

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  E +VPM P
Sbjct: 790  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGEELVPMKP 849

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI--TDGSP 546
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I   D  P
Sbjct: 850  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKADKVP 907

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
            +     I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 908  S----FIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEG 963

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 964  RITRYETPEDILRAFYAVRIKLYEKRKQHLLSELQTHLDKLSNQARFVQMIIDGKLVISK 1023

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAG 697
            +KKA L+ ELQ+KGF P P+   + EP  AG
Sbjct: 1024 KKKALLIQELQEKGFKPFPRVADTPEPGDAG 1054


>L7JVE8_TRAHO (tr|L7JVE8) DNA topoisomerase 2 (Fragment) OS=Trachipleistophora
            hominis GN=THOM_1646 PE=3 SV=1
          Length = 1474

 Score =  725 bits (1871), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 379/778 (48%), Positives = 505/778 (64%), Gaps = 84/778 (10%)

Query: 20   DTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALA 79
            D +LS A  K SK LKKTDG+K+ ++ GI KL DAN AG +NS KC+LILTEGDSAK LA
Sbjct: 407  DRVLSQALAKMSKQLKKTDGSKSSKITGIEKLSDANLAGTKNSQKCSLILTEGDSAKTLA 466

Query: 80   MAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKSLR 139
            ++GLSVVGRD+YGVFPLRGKLLNVREA++KQIM+NEE+ N+KKIL LQ +K+Y++ +SLR
Sbjct: 467  ISGLSVVGRDYYGVFPLRGKLLNVREANHKQIMENEELNNLKKILALQHHKDYTSTESLR 526

Query: 140  YGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF---------- 189
            YGH++IM DQDHDGSHIKGL+INF   F+PSLL++  F+ EF TPI+R            
Sbjct: 527  YGHVIIMTDQDHDGSHIKGLIINFFDHFFPSLLRIEGFLKEFITPIVRVTKTKGSRTSRS 586

Query: 190  --------HSN--------GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQE 233
                    H+N        GT + F+++PEYE W+ N   +   W +KYYKGLGTST ++
Sbjct: 587  NSEDDSDEHTNTPASSDPVGTVIDFFTIPEYEDWK-NSTPDIKNWTVKYYKGLGTSTSKD 645

Query: 234  GREYFRDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINY 293
             ++YF +L KH K F      D S I++AF+KKKA+DRK+W++N  PG + DH A +I  
Sbjct: 646  AKQYFSNLEKHVKSFTLLTTEDQSLIDLAFNKKKADDRKLWLKNCVPGTFLDHSAHKIPI 705

Query: 294  KDFVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHS 353
            +DF+NKELILFS AD  RSIPSVVDG KPGQRK+++C FK+ L  EIKV Q +GYV+EHS
Sbjct: 706  RDFINKELILFSMADNVRSIPSVVDGFKPGQRKVMYCCFKRNLKSEIKVAQLVGYVAEHS 765

Query: 354  AYHHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITR 413
            AYHHGE SL  TII +A DFVGSNNINLL P GQFGTR  GGKD AS+RYI+T L  ITR
Sbjct: 766  AYHHGEVSLQQTIIKLAHDFVGSNNINLLMPEGQFGTRLQGGKDAASARYIFTNLASITR 825

Query: 414  CLFHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIAN 473
             +F E+DD LL Y+ ED   IEPS+Y+PI+P+VLVNG++GIGTGW + IPNY+  +II N
Sbjct: 826  KIFVESDDALLNYITEDNMKIEPSFYVPIVPMVLVNGADGIGTGWLTKIPNYDLLEIIDN 885

Query: 474  VRRLLNDETMVPMDPWYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWT 531
            ++ LL+D+ M  M P+YRGFKG IE     GG  Y ++G + ++D  +  ITELP++ WT
Sbjct: 886  IKLLLDDQEMNTMVPFYRGFKGEIEDL---GGKKYRISG-IYDVDGDNLTITELPVKIWT 941

Query: 532  QDYKQFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLT 591
            Q YK+FLE        ++   +++FR+   +  V  E+ + +          + KKF L+
Sbjct: 942  QTYKEFLEK------KIEKGDVKEFREYHTERSVHFEVNLAVSG-------EIDKKFSLS 988

Query: 592  TTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKV 651
            +    +N   FD  GKIKKYE+ E+IL EF+ +RL++Y  RK ++L   E  L  L NKV
Sbjct: 989  SINIFNNFVCFDRHGKIKKYESAEEILREFYSIRLEFYNLRKAHMLNTLEEQLKRLHNKV 1048

Query: 652  RFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXX 711
            RFI  VV+G +VVS RKK D++ EL++K +  +                           
Sbjct: 1049 RFIKEVVNGTLVVSKRKKTDIIAELERKEYYKI--------------------------- 1081

Query: 712  XXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
                          Y+YLL+M+I +LTLE ++                    +K +W+
Sbjct: 1082 -----------EDTYDYLLNMAILSLTLEKIERLNEEYRNTQREYDELLGKSAKELWI 1128


>Q76C37_9EURO (tr|Q76C37) DNA topoisomerase 2 (Fragment) OS=Trichophyton
            quinckeanum GN=top2 PE=3 SV=1
          Length = 1089

 Score =  724 bits (1870), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 358/690 (51%), Positives = 481/690 (69%), Gaps = 12/690 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +   
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGS 552

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N T   SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHTKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNI 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTDVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAG 697
            KKA L+ ELQ+KGF P PK   + EP  AG
Sbjct: 1027 KKAVLIQELQEKGFKPFPKVVGTPEPGEAG 1056


>Q76C33_TRIVC (tr|Q76C33) DNA topoisomerase 2 (Fragment) OS=Trichophyton verrucosum
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  723 bits (1867), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 357/686 (52%), Positives = 478/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 552

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHSKSFFTIPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG  E S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKG--EVSGSGDRYKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ GE+V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGELVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1027 KKAVLIQELQEKGFKPFPKVVGTPEP 1052


>C6H7L1_AJECH (tr|C6H7L1) DNA topoisomerase 2 OS=Ajellomyces capsulata (strain
            H143) GN=HCDG_02412 PE=3 SV=1
          Length = 1737

 Score =  723 bits (1866), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 379/816 (46%), Positives = 512/816 (62%), Gaps = 21/816 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 511  ILKTQVMENILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 569

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG ++VG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  LGLQ  KEY
Sbjct: 570  DSAKGLAMAGRAIVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFLGLQHKKEY 629

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF    +PSLLK+P F++EF TPI++ +  +
Sbjct: 630  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFFQVAFPSLLKIPQFLIEFITPIVKVWKGD 689

Query: 193  GTKLS----FYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                +    F++M EY++W+E  G++   W+ KYYKGLGTS+  +   YFRDL KH K F
Sbjct: 690  PKNPTISKVFFTMQEYKTWQEIHGHDKR-WEKKYYKGLGTSSTDDAEIYFRDLDKHLKQF 748

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R F+PG + DH    I Y DF+NKELILFS AD
Sbjct: 749  HVMQDHEAELIDLAFSKKKADERKEWLRQFKPGTFLDHTTDEITYTDFINKELILFSMAD 808

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV+DGLKPGQRK+L+  FK+ + K++KV +  GYV   +AY HGEQSL  TIIG
Sbjct: 809  NIRSIPSVIDGLKPGQRKVLYTCFKRNVKKDVKVAELSGYVLGMTAYQHGEQSLQQTIIG 868

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ+FVGSNNIN L+P+G FG+R  GG D AS RYIYT L+P  R +FHE D+ LL Y  
Sbjct: 869  LAQNFVGSNNINCLEPSGNFGSRLQGGSDAASPRYIYTRLSPFARRIFHEADEPLLTYNV 928

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y P++P++L+NG+EGIGTGWS+ IPNYNP +I+AN++RL+  E +VPM+P
Sbjct: 929  DDGQVIEPEIYFPVVPMILINGAEGIGTGWSTSIPNYNPEEIVANLKRLMAGEPLVPMEP 988

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     E  Y  +G + +I +    ITELPIR WTQD+K  LE I       
Sbjct: 989  WFRGFTGEVVSMGGE-RYKFSGRISQIGDNEVEITELPIRSWTQDFKDRLEEIIKAE--- 1044

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I++  +     + EGL +KFKLT TI+TSN+  FD+EG+
Sbjct: 1045 KVPSFIKDYKDYNTHTKVHFIIQLDEKYAKKAIAEGLEEKFKLTKTIATSNLVAFDSEGR 1104

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KYE+ E+IL EFF +RL  YE+RKQ+ L   ++ L  + N+ RF+  ++ G+ V+S +
Sbjct: 1105 ITKYESVEEILREFFSVRLKLYEKRKQHQLSQMQKDLEKMTNQARFVQMIIDGKFVISKK 1164

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
             KA L+ EL++KGF P  K        V+ A                           Y+
Sbjct: 1165 PKAQLVRELKEKGFKPFAK--------VSDAAAKGENAPVVEEDEDDDGEDTEIAANSYD 1216

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL M + +LT E V+                     + +W             Q   E 
Sbjct: 1217 YLLGMPLWSLTKERVEKLRRQIGDKETEIDTLIKLSKEDIWTADLDDFLAEWKFQLEDEE 1276

Query: 788  EDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKK 823
              + KR +++++R ST+ L T A K   +PR  + K
Sbjct: 1277 RRQTKR-TKSARRVSTK-LKTAATKSARKPRAASSK 1310


>Q4WLF7_ASPFU (tr|Q4WLF7) DNA topoisomerase 2 OS=Neosartorya fumigata (strain ATCC
            MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
            GN=AFUA_6G13690 PE=3 SV=1
          Length = 1660

 Score =  723 bits (1866), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 356/675 (52%), Positives = 480/675 (71%), Gaps = 13/675 (1%)

Query: 18   ILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKA 77
            +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEGDSAK 
Sbjct: 436  VMNNILHFAQAKADQLLKKTDGGRRTRMNN-PKLVDANKAGTKDGHHCTLILTEGDSAKG 494

Query: 78   LAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKS 137
            LAMAG +VVG D +GVFPLRGKLLNVR+AS +QI  N+EIQNIK  LGLQ  KEY++ + 
Sbjct: 495  LAMAGRAVVGPDLFGVFPLRGKLLNVRDASFEQISKNQEIQNIKNFLGLQHKKEYTDTRG 554

Query: 138  LRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS---NGT 194
            LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPI + +     N T
Sbjct: 555  LRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIAKVWKGDPKNPT 614

Query: 195  KL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDD 253
            K  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F    D
Sbjct: 615  KQHSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEFHTLQD 673

Query: 254  YDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
            ++   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+NKELILFS AD QRSI
Sbjct: 674  HETELIELAFSKKKADERKEWLRQFKPGTFLDHSVDKITYTDFINKELILFSMADNQRSI 733

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            PSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G+AQ F
Sbjct: 734  PSVVDGLKPGQRKVLYTCFRRNLRKDMKVVELAGHVSGMTAYQHGDASLQQTIVGLAQTF 793

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
            VGSNNIN L+P+G FG+R  GG+D AS+RYIYT L+P  R +FH  DD LL Y  +DG+ 
Sbjct: 794  VGSNNINCLEPSGNFGSRLQGGQDCASARYIYTRLSPFARRVFHAADDPLLTYNEDDGKK 853

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP DI+ N++RL++ + + PM PW+RGF
Sbjct: 854  IEPEVYVPVVPMILINGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGQPVKPMQPWFRGF 913

Query: 494  KGIIEKSAKEGG-YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP- 551
             G  E +A  G  +  +G ++E  ++   ITELPIR WTQD+K  LE I       K P 
Sbjct: 914  TG--EVTALGGDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEEIIKAE---KTPS 968

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I+D++       V   I+M  + +    +EGL +KFKL+ TI+T+N+  FD EG+I KY
Sbjct: 969  FIKDYKDYNTHTKVHFVIQMDEKNLQSAREEGLEEKFKLSKTIATTNLVAFDPEGRITKY 1028

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
             + + IL+EF+ +RL +YERRKQY L   ++ L  L N+ RF+  ++ G++V+S +KK  
Sbjct: 1029 ASVDDILKEFYAVRLKFYERRKQYQLNELQKELDKLTNQARFVQMIIDGDLVISKKKKPA 1088

Query: 672  LLMELQQKGFTPMPK 686
            L+ EL++ GF   PK
Sbjct: 1089 LVAELKKHGFKAFPK 1103


>B0XM58_ASPFC (tr|B0XM58) DNA topoisomerase 2 OS=Neosartorya fumigata (strain CEA10
            / CBS 144.89 / FGSC A1163) GN=AFUB_001050 PE=3 SV=1
          Length = 1660

 Score =  723 bits (1866), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 356/675 (52%), Positives = 480/675 (71%), Gaps = 13/675 (1%)

Query: 18   ILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKA 77
            +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEGDSAK 
Sbjct: 436  VMNNILHFAQAKADQLLKKTDGGRRTRMNN-PKLVDANKAGTKDGHHCTLILTEGDSAKG 494

Query: 78   LAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKS 137
            LAMAG +VVG D +GVFPLRGKLLNVR+AS +QI  N+EIQNIK  LGLQ  KEY++ + 
Sbjct: 495  LAMAGRAVVGPDLFGVFPLRGKLLNVRDASFEQISKNQEIQNIKNFLGLQHKKEYTDTRG 554

Query: 138  LRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS---NGT 194
            LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPI + +     N T
Sbjct: 555  LRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIAKVWKGDPKNPT 614

Query: 195  KL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDD 253
            K  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F    D
Sbjct: 615  KQHSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEFHTLQD 673

Query: 254  YDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSI 313
            ++   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+NKELILFS AD QRSI
Sbjct: 674  HETELIELAFSKKKADERKEWLRQFKPGTFLDHSVDKITYTDFINKELILFSMADNQRSI 733

Query: 314  PSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDF 373
            PSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G+AQ F
Sbjct: 734  PSVVDGLKPGQRKVLYTCFRRNLRKDMKVVELAGHVSGMTAYQHGDASLQQTIVGLAQTF 793

Query: 374  VGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRS 433
            VGSNNIN L+P+G FG+R  GG+D AS+RYIYT L+P  R +FH  DD LL Y  +DG+ 
Sbjct: 794  VGSNNINCLEPSGNFGSRLQGGQDCASARYIYTRLSPFARRVFHAADDPLLTYNEDDGKK 853

Query: 434  IEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGF 493
            IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP DI+ N++RL++ + + PM PW+RGF
Sbjct: 854  IEPEVYVPVVPMILINGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGQPVKPMQPWFRGF 913

Query: 494  KGIIEKSAKEGG-YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDP- 551
             G  E +A  G  +  +G ++E  ++   ITELPIR WTQD+K  LE I       K P 
Sbjct: 914  TG--EVTALGGDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEEIIKAE---KTPS 968

Query: 552  LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKY 611
             I+D++       V   I+M  + +    +EGL +KFKL+ TI+T+N+  FD EG+I KY
Sbjct: 969  FIKDYKDYNTHTKVHFVIQMDEKNLQSAREEGLEEKFKLSKTIATTNLVAFDPEGRITKY 1028

Query: 612  ENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKAD 671
             + + IL+EF+ +RL +YERRKQY L   ++ L  L N+ RF+  ++ G++V+S +KK  
Sbjct: 1029 ASVDDILKEFYAVRLKFYERRKQYQLNELQKELDKLTNQARFVQMIIDGDLVISKKKKPA 1088

Query: 672  LLMELQQKGFTPMPK 686
            L+ EL++ GF   PK
Sbjct: 1089 LVAELKKHGFKAFPK 1103


>C0NX13_AJECG (tr|C0NX13) DNA topoisomerase 2 OS=Ajellomyces capsulata (strain
            G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) GN=HCBG_08005
            PE=3 SV=1
          Length = 1716

 Score =  723 bits (1866), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 385/832 (46%), Positives = 517/832 (62%), Gaps = 28/832 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 415  ILKTQVMENILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 473

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG ++VG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  LGLQ  KEY
Sbjct: 474  DSAKGLAMAGRAIVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFLGLQHKKEY 533

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF    +PSLLK+P F++EF TPI++ +  +
Sbjct: 534  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFFQVAFPSLLKIPQFLIEFITPIVKVWKGD 593

Query: 193  GTKLS----FYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                +    F++M EY++W+E  G++   W+ KYYKGLGTS+  +   YFRDL KH K F
Sbjct: 594  PKNPTISKVFFTMQEYKTWQEIHGHDKR-WEKKYYKGLGTSSTDDAEIYFRDLDKHLKQF 652

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R F+PG + DH    I Y DF+NKELILFS AD
Sbjct: 653  HVMQDHEAELIDLAFSKKKADERKEWLRQFKPGTFLDHTTDEITYTDFINKELILFSMAD 712

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYV   +AY HGEQSL  TIIG
Sbjct: 713  NIRSIPSVVDGLKPGQRKVLYTCFKRNVKKDVKVAELSGYVLGMTAYQHGEQSLQQTIIG 772

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ+FVGSNNIN L+P+G FG+R  GG D AS RYIYT L+P  R +FHE D+ LL Y  
Sbjct: 773  LAQNFVGSNNINCLEPSGNFGSRLQGGSDAASPRYIYTRLSPFARRIFHEADEPLLTYNV 832

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y P++P++L+NG+EGIGTGWS+ IPNYNP +I+AN++RL+  E +VPM+P
Sbjct: 833  DDGQVIEPEIYFPVVPMILINGAEGIGTGWSTSIPNYNPEEIVANLKRLMAGEPLVPMEP 892

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     E  Y  +G + +I +    ITELPIR WTQD+K  LE I       
Sbjct: 893  WFRGFTGEVVSMGGE-RYKFSGRISQIGDNEVEITELPIRSWTQDFKDRLEEIIKAE--- 948

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I++  +     + EGL +KFKLT TI+TSN+  FD+EG+
Sbjct: 949  KVPSFIKDYKDYNTHTKVHFIIQLDEKYAKKAIAEGLEEKFKLTKTIATSNLVAFDSEGR 1008

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KYE+ E+IL EFF +RL  YE+RKQ+ L   ++ L  + N+ RF+  ++ G+ V+S +
Sbjct: 1009 ITKYESVEEILREFFSVRLKLYEKRKQHQLSQMQKDLEKMTNQARFVQMIIDGKFVISKK 1068

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
             KA L+ EL++KGF P  K        V+ A                           Y+
Sbjct: 1069 PKAQLVRELKEKGFKPFAK--------VSDAAAKGENAPVVEEDEDDDGEDTQIAANSYD 1120

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL M + +LT E V+                     + +W             Q   E 
Sbjct: 1121 YLLGMPLWSLTKERVEKLRRQIGDKETEIDTLIKLSKEDIWTADLDDFLAEWKFQLEDEE 1180

Query: 788  EDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMETGKP 839
              + KR +++++R ST+ L T A        K  KK K A+ D+S     KP
Sbjct: 1181 RRQTKR-TKSARRVSTK-LKTAAT-------KGGKKRKAADDDDSDFGLPKP 1223


>A6RG78_AJECN (tr|A6RG78) DNA topoisomerase 2 OS=Ajellomyces capsulata (strain NAm1
            / WU24) GN=HCAG_08644 PE=3 SV=1
          Length = 1808

 Score =  723 bits (1866), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 386/832 (46%), Positives = 517/832 (62%), Gaps = 28/832 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 511  ILKTQVMENILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 569

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG ++VG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  LGLQ  KEY
Sbjct: 570  DSAKGLAMAGRAIVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFLGLQHKKEY 629

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF    +PSLLK+P F++EF TPI++ +  +
Sbjct: 630  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFFQVAFPSLLKIPQFLIEFITPIVKVWKGD 689

Query: 193  GTKLS----FYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                +    F++M EY++W+E  G++   W+ KYYKGLGTS+  +   YFRDL KH K F
Sbjct: 690  PKNPTISKVFFTMQEYKTWQEIHGHDKR-WEKKYYKGLGTSSTDDAEIYFRDLDKHLKQF 748

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R F+PG + DH    I Y DFVNKELILFS AD
Sbjct: 749  HVMQDHEAELIDLAFSKKKADERKEWLRQFKPGTFLDHTTDEITYTDFVNKELILFSMAD 808

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYV   +AY HGEQSL  TIIG
Sbjct: 809  NIRSIPSVVDGLKPGQRKVLYTCFKRNVKKDVKVAELSGYVLGMTAYQHGEQSLQQTIIG 868

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ+FVGSNNIN L+P+G FG+R  GG D AS RYIYT L+P  R +FHE D+ LL Y  
Sbjct: 869  LAQNFVGSNNINCLEPSGNFGSRLQGGSDAASPRYIYTRLSPFARRIFHEADEPLLTYNV 928

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y P++P++L+NG+EGIGTGWS+ IPNYNP +I+AN++RL+  E +VPM+P
Sbjct: 929  DDGQVIEPEIYFPVVPMILINGAEGIGTGWSTSIPNYNPEEIVANLKRLMAGEPLVPMEP 988

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     E  Y  +G + +I +    ITELPIR WTQD+K  LE I       
Sbjct: 989  WFRGFTGEVVSMGGE-RYKFSGRISQIGDNEVEITELPIRSWTQDFKDRLEEIIKAE--- 1044

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I++  +     + EGL +KFKLT TI+TSN+  FD EG+
Sbjct: 1045 KVPSFIKDYKDYNTHTKVHFIIQLDEKYAKKAIAEGLEEKFKLTKTIATSNLVAFDPEGR 1104

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KYE+ E+IL EFF +RL  YE+RKQ+ L   ++ L  + N+ RF+  ++ G+ V+S +
Sbjct: 1105 ITKYESVEEILREFFSVRLKLYEKRKQHQLSQMQKDLEKMTNQARFVQMIIDGKFVISKK 1164

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
             KA L+ EL++KGF P  K        V+ A                           Y+
Sbjct: 1165 PKAQLVRELKEKGFKPFAK--------VSDAAAKGENAPVVEEDEDDDGEDTEIAANSYD 1216

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL M + +LT E V+                     + +W             Q  +E 
Sbjct: 1217 YLLGMPLWSLTKERVEKLRRQIGDKETEIDTLIKLSKEDIWTADLDDFLAEWKFQLEEEE 1276

Query: 788  EDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMETGKP 839
              + KR +++++R ST+ L T A        K  KK K A+ D+S     KP
Sbjct: 1277 RQQTKR-TKSARRVSTK-LKTAAT-------KGGKKRKAADDDDSDFGLLKP 1319


>A5K0R4_PLAVS (tr|A5K0R4) DNA topoisomerase 2 OS=Plasmodium vivax (strain Salvador
            I) GN=PVX_084855 PE=3 SV=1
          Length = 1502

 Score =  723 bits (1866), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 388/799 (48%), Positives = 517/799 (64%), Gaps = 18/799 (2%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTL 67
            +V  S IL  +L WA  K   +L+K          +R+ GI KLEDANDAG + S +CTL
Sbjct: 447  SVLKSPILSNILLWAQAKAQVELRKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTL 506

Query: 68   ILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ 127
            ILTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI KI+GL 
Sbjct: 507  ILTEGDSAKTSCLAGLSIVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFKIMGLD 566

Query: 128  -QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPII 186
              +K   ++K LRYG LMIM DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI+
Sbjct: 567  ITDKNKEDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIV 626

Query: 187  RAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
            +    N  + SF+++ EYE W+E+   N  GWKIKYYKGLGTST +E ++YF D+  H+ 
Sbjct: 627  KVQKGN-QEHSFFTIAEYEQWKES--TNLVGWKIKYYKGLGTSTDKEFKQYFSDIKNHKI 683

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
             F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR
Sbjct: 684  MFLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFIIGSYVDHKEKDLSYYDFVNKELIYYSR 743

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
             D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TI
Sbjct: 744  YDTERSIPNIMDGWKPGQRKVLYGCFKRNLKNECKVAQLVGYIAEHSAYHHGESSLQQTI 803

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            I MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR +F+E DD +L+Y
Sbjct: 804  INMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKY 863

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            LNE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N++R +N E ++PM
Sbjct: 864  LNEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIENIKRYINKEPLLPM 923

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PWY+ FKG IE + K  GY   G + +ID+++  I ELPI+KWTQDYK+FLE +     
Sbjct: 924  IPWYKDFKGRIESNGK-TGYETIGIIHKIDDETLEINELPIKKWTQDYKEFLEELL---T 979

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
            + K  LI D+  N     +   I+M   K+    +EGL K FKL +T++T+NM LFD   
Sbjct: 980  DEKHQLIVDYIDNSSHEDICFTIKMDPAKMKKAEEEGLEKVFKLKSTLTTTNMTLFDPNL 1039

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            K+++Y     IL++F   RL  YE RK Y++   E+   ++ NK +FIL +V+ E+VVS 
Sbjct: 1040 KLQRYSTELDILKDFCFHRLKAYENRKSYLISKLEKEKKIISNKSKFILAIVNNELVVSK 1099

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDY 726
            +KK  L+ EL +KG+ P     K  + ++                             DY
Sbjct: 1100 KKKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLESVENPEDNEEIIAGISVK----DY 1155

Query: 727  EYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKE 786
            +YLLSM I +LTLE V+                     ++MW+            Q   E
Sbjct: 1156 DYLLSMPIFSLTLEKVEELLAQHKEKEKELEILKNITVETMWLKDIEKVEEAIEFQRNVE 1215

Query: 787  A--EDEKKRISQASKRTST 803
                +E  R   A K+T++
Sbjct: 1216 LANREESNRFKVAKKQTAS 1234


>Q76C35_9EURO (tr|Q76C35) DNA topoisomerase 2 (Fragment) OS=Arthroderma simii
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  723 bits (1865), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/686 (51%), Positives = 477/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  N
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGN 552

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHSKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNI 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTDVHFIIQMDEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1027 KKAVLIQELQEKGFKPFPKVVDTPEP 1052


>Q76C34_TRITO (tr|Q76C34) DNA topoisomerase 2 (Fragment) OS=Trichophyton tonsurans
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  723 bits (1865), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 358/691 (51%), Positives = 481/691 (69%), Gaps = 14/691 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  N
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGN 552

Query: 193  -----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                  TK SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K 
Sbjct: 553  PKNPTHTK-SFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQ 610

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F    D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS A
Sbjct: 611  FHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMA 670

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HG+ SL +TI+
Sbjct: 671  DNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDVKVVELAGYVSGMTAYQHGDNSLHTTIV 730

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL   
Sbjct: 731  GLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNN 790

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM 
Sbjct: 791  IDDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGEELVPMK 850

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PW+RGFKG +  S     Y  +G +++  +    ITELPI  WTQD+K  LE I      
Sbjct: 851  PWFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPICTWTQDFKDKLEEIIKAE-- 906

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 907  -KVPSFIKDYKDYNTHTDVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEG 965

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 966  RITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISK 1025

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAG 697
            +KKA L+ ELQ+KGF P PK   + EP  AG
Sbjct: 1026 KKKAVLIQELQEKGFKPFPKVVGTPEPGEAG 1056


>F0UWA9_AJEC8 (tr|F0UWA9) DNA topoisomerase 2 OS=Ajellomyces capsulata (strain H88)
            GN=HCEG_09401 PE=3 SV=1
          Length = 1712

 Score =  723 bits (1865), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 384/832 (46%), Positives = 518/832 (62%), Gaps = 28/832 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 415  ILKTQVMENILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 473

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG ++VG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  LGLQ  KEY
Sbjct: 474  DSAKGLAMAGRAIVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFLGLQHKKEY 533

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF    +PSLLK+P F++EF TPI++ +  +
Sbjct: 534  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFFQVAFPSLLKIPQFLIEFITPIVKVWKGD 593

Query: 193  GTKLS----FYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                +    F++M EY++W+E  G++   W+ KYYKGLGTS+  +   YFRDL KH K F
Sbjct: 594  PKNPTISKVFFTMQEYKTWQEIHGHDKR-WEKKYYKGLGTSSTDDAEIYFRDLDKHLKQF 652

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R F+PG + DH    I Y DF+NKELILFS AD
Sbjct: 653  HVMQDHEAELIDLAFSKKKADERKEWLRQFKPGTFLDHTTDEITYTDFINKELILFSMAD 712

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV+DGLKPGQRK+L+  FK+ + K++KV +  GYV   +AY HGEQSL  TIIG
Sbjct: 713  NIRSIPSVIDGLKPGQRKVLYTCFKRNVKKDVKVAELSGYVLGMTAYQHGEQSLQQTIIG 772

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ+FVGSNNIN L+P+G FG+R  GG D AS RYIYT L+P  R +FHE D+ LL Y  
Sbjct: 773  LAQNFVGSNNINCLEPSGNFGSRLQGGSDAASPRYIYTRLSPFARRIFHEADEPLLTYNV 832

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y P++P++L+NG+EGIGTGWS+ IPNYNP +I+AN++RL+  E +VPM+P
Sbjct: 833  DDGQVIEPEIYFPVVPMILINGAEGIGTGWSTSIPNYNPEEIVANLKRLMAGEPLVPMEP 892

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     E  Y  +G + +I +    ITELPIR WTQD+K  LE I       
Sbjct: 893  WFRGFTGEVVSMGGE-RYKFSGRISQIGDNEVEITELPIRSWTQDFKDRLEEIIKAE--- 948

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I++  +     + EGL +KFKLT TI+TSN+  FD+EG+
Sbjct: 949  KVPSFIKDYKDYNTHTKVHFIIQLDEKYAKKAIAEGLEEKFKLTKTIATSNLVAFDSEGR 1008

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KYE+ E+IL EFF +RL  YE+RKQ+ L   ++ L  + N+ RF+  ++ G+ V+S +
Sbjct: 1009 ITKYESVEEILREFFSVRLKLYEKRKQHQLSQMQKDLEKMTNQARFVQMIIDGKFVISKK 1068

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
             KA L+ EL++KGF P  K        V+ A                           Y+
Sbjct: 1069 PKAQLVRELKEKGFKPFAK--------VSDAAAKGENAPVVEEDEDDDGEDTEIAANSYD 1120

Query: 728  YLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXXXXXXXXXXQDGKEA 787
            YLL M + +LT E V+                     + +W             Q   E 
Sbjct: 1121 YLLGMPLWSLTKERVEKLRRQIGDKETEINTLIKLSKEDIWTADLDDFLAEWKFQLEDEE 1180

Query: 788  EDEKKRISQASKRTSTRDLGTKAAKKPPQPRKNTKKTKNAESDNSPMETGKP 839
              + KR +++++R ST+ L T A        K+ KK K A+ D+S     KP
Sbjct: 1181 RRQTKR-TKSARRVSTK-LKTAAT-------KSGKKRKAADDDDSDFGLPKP 1223


>J3KAE2_COCIM (tr|J3KAE2) DNA topoisomerase 2 OS=Coccidioides immitis (strain RS)
            GN=CIMG_02836 PE=3 SV=1
          Length = 1718

 Score =  723 bits (1865), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 346/685 (50%), Positives = 484/685 (70%), Gaps = 12/685 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + ++  ++ +A+ K  + LKKTDG++  R+    KL DAN AG +    CTLILTEG
Sbjct: 510  ILKTQVMQNIMHFAEQKADQILKKTDGSRRARMNN-PKLTDANKAGTKEGHHCTLILTEG 568

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK  LGLQ  KEY
Sbjct: 569  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNQEIQNIKNFLGLQHKKEY 628

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +PSLLK+P F++EF TPI++ +  +
Sbjct: 629  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPSLLKIPGFLIEFITPIVKVWKGD 688

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+++ G++   W  KYYKGLGTS+ ++   YFRDL +H K+F
Sbjct: 689  PKNPTASKSFFTLPEYEEWKKSHGHDRR-WDKKYYKGLGTSSTEDAEVYFRDLDRHLKEF 747

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   I++AFSKKKA+DRK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 748  HAMQDNEAQLIDLAFSKKKADDRKEWLRQFKPGTYLDHSVDKITYTDFINKELILFSMAD 807

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HGE SL  TI+G
Sbjct: 808  NIRSIPSVVDGLKPGQRKVLYAMFKRNVKKDMKVVELGGYVSGMTAYQHGEASLQQTIVG 867

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYI+T L+P  R +FH  D+ LL+   
Sbjct: 868  LAQTFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIHTRLSPFARRIFHAADEPLLKSNI 927

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++P++L+NG++GIGTGWS+ IPN+NP DI+AN+RRL++ E++VPM P
Sbjct: 928  DDGKVIEPEVYVPVVPMILINGADGIGTGWSTSIPNFNPEDIVANLRRLMDGESLVPMKP 987

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G  E +A    Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 988  WFRGFTG--EVTASGDRYKFSGIIKQTGDCEVEITELPIRTWTQDFKDKLEEIIKAE--- 1042

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++     + V   I+M  + +   +++GL ++FKL+ TI+T+NM  FDAEG+
Sbjct: 1043 KAPSFIKDYKDYNTHSKVHFIIQMDEKHMKKALEDGLEERFKLSKTIATTNMVAFDAEGR 1102

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY+  E IL+ F+ +R+ +YE+RKQ++L    + L    N+ RF+  ++ G++V+S +
Sbjct: 1103 ITKYDTAEDILKAFYAVRIRFYEKRKQHLLAQLHKELDKFTNQARFVQMIIDGKLVISKK 1162

Query: 668  KKADLLMELQQKGFTPMPKKGKSAE 692
            +KA L+ EL++KGF P+PK   +A+
Sbjct: 1163 RKAKLIEELKEKGFKPIPKAVDAAK 1187


>Q8X1U5_ASPFM (tr|Q8X1U5) DNA topoisomerase 2 (Fragment) OS=Neosartorya fumigata
            GN=TOP 2 PE=3 SV=1
          Length = 1495

 Score =  723 bits (1865), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 356/680 (52%), Positives = 484/680 (71%), Gaps = 13/680 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 431  ILRTEVMNNILHFAQAKADQLLKKTDGGRRTRMNN-PKLVDANKAGTKDGHHCTLILTEG 489

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS +QI  N+EIQNIK  LGLQ  KEY
Sbjct: 490  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFEQISKNQEIQNIKNFLGLQHKKEY 549

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPI + +   
Sbjct: 550  THTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIAKVWKGD 609

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE+W+E+  ++  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 610  PKNPTKQHSFFTMPEYEAWKEDHKHD-RGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 668

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   IE+AFSKKKA++RK W+R F+PG + DH   +I Y DF+NKELILFS AD
Sbjct: 669  HTLQDHETELIELAFSKKKADERKEWLRQFKPGTFLDHSVDKITYTDFINKELILFSMAD 728

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 729  NQRSIPSVVDGLKPGQRKVLYTCFRRNLRKDMKVVELAGHVSGMTAYQHGDASLQQTIVG 788

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG+D AS+RYIYT L+P  R +FH  DD LL Y  
Sbjct: 789  LAQTFVGSNNINCLEPSGNFGSRLQGGQDCASARYIYTRLSPFARRVFHAADDPLLTYNE 848

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++P++L+NG++GIGTGWSS IPNYNP DI+ N++RL++ + + PM P
Sbjct: 849  DDGKKIEPEVYVPVVPMILINGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGQPVKPMQP 908

Query: 489  WYRGFKGIIEKSAKEGG-YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            W+RGF G  E +A  G  +  +G ++E  ++   ITELPIR WTQD+K  LE I      
Sbjct: 909  WFRGFTG--EVTALGGDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEEIIKAE-- 964

Query: 548  VKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
             K P  I+D++       V   I+M  + +    +EGL +KFKL+ TI+T+N+  FD EG
Sbjct: 965  -KTPSFIKDYKDYNTHTKVHFVIQMDEKNLQSAREEGLEEKFKLSKTIATTNLVAFDPEG 1023

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I KY + + IL+EF+ +RL +YERRKQY L   ++ L  L N+ RF+  ++ G++V+S 
Sbjct: 1024 RITKYASVDDILKEFYAVRLKFYERRKQYQLNELQKELDKLTNQARFVQMIIDGDLVISK 1083

Query: 667  RKKADLLMELQQKGFTPMPK 686
            +KK  L+ EL++ GF   PK
Sbjct: 1084 KKKPALVAELKKHGFKAFPK 1103


>Q76C31_ARTBE (tr|Q76C31) DNA topoisomerase 2 (Fragment) OS=Arthroderma benhamiae
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  722 bits (1863), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/686 (51%), Positives = 478/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 552

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHSKSFFTIPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1027 KKAVLIQELQEKGFKPFPKVVGTPEP 1052


>Q76C32_ARTBE (tr|Q76C32) DNA topoisomerase 2 (Fragment) OS=Arthroderma benhamiae
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  722 bits (1863), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/686 (51%), Positives = 478/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 552

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHSKSFFTIPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1027 KKAVLIQELQEKGFKPFPKVVGTPEP 1052


>Q8J2R8_ARTOT (tr|Q8J2R8) DNA topoisomerase 2 (Fragment) OS=Arthroderma otae
            GN=top2 PE=3 SV=1
          Length = 1087

 Score =  721 bits (1861), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/686 (51%), Positives = 475/686 (69%), Gaps = 14/686 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 375  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 433

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 434  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 493

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 494  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 553

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL KH K F
Sbjct: 554  PKNPTHSKSFFTLPEYEEWKETHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDKHLKQF 612

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 613  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTEQITYSDFINKELILFSMAD 672

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV+DGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 673  NIRSIPSVIDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 732

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH  D+ LL    
Sbjct: 733  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHPADEPLLVNNT 792

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++AN++RL+  E +VPM P
Sbjct: 793  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVANLKRLMAGEELVPMKP 852

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI--TDGSP 546
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I   D  P
Sbjct: 853  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEITELPIRTWTQDFKDRLEEIIKADKVP 910

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
            +     I+D++       V   I+M  + +   ++EGL +KFKL   I+TSNM  FDAEG
Sbjct: 911  S----FIKDYKDYNTHTNVHFIIQMDEKHMKKALEEGLEEKFKLIKPIATSNMVAFDAEG 966

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            +I +YE PE IL+ F+ +R+  YERRKQ++L   +  L  L N+ RF+  ++ G++V+S 
Sbjct: 967  RITRYETPEDILQAFYAVRIKLYERRKQHLLSQLQSQLDKLSNQARFVQMIIDGKLVISK 1026

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAE 692
            +KK  L+ EL+ K F P PK   +A+
Sbjct: 1027 KKKTILIQELKDKAFKPFPKVADTAK 1052


>F2QWR7_PICP7 (tr|F2QWR7) DNA topoisomerase 2 OS=Komagataella pastoris (strain ATCC
            76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner
            21-1) GN=PP7435_Chr3-0893 PE=3 SV=1
          Length = 1312

 Score =  721 bits (1861), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 370/739 (50%), Positives = 499/739 (67%), Gaps = 17/739 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  +GI+D +L  A     K LKK DG++  R+ G  KLEDAN AG +   KCTLILTEG
Sbjct: 454  ILRTGIVDAILDIAAMNADKALKKNDGSRKNRITGYPKLEDANKAGTKEGYKCTLILTEG 513

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSA +LA+AGL+VVGRD+YGV+PLRGK+LNVREAS  QIM N EIQ IK+I+G Q  K Y
Sbjct: 514  DSASSLAVAGLAVVGRDYYGVYPLRGKMLNVREASADQIMKNAEIQAIKQIMGFQHKKNY 573

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
            +  N+ SLRYGH+MIM DQDHDGSHIKGL+INF+ S +P LLKVP+F++EF TPI++   
Sbjct: 574  TPENINSLRYGHIMIMTDQDHDGSHIKGLIINFLESSFPGLLKVPNFLLEFITPIVKVTI 633

Query: 191  SNGTK----LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
            ++G +    + FYSMPEYE+WRE    N   +K KYYKGLGTS  +E REYF  L KH K
Sbjct: 634  TSGPEKRKVIPFYSMPEYEAWREQ---NTESFKQKYYKGLGTSLAEEMREYFSQLDKHMK 690

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
             F    D D   I++AFSKKKA+DRK W+R FEPG + D   S I   DF+NKELILFS 
Sbjct: 691  TFHALQDVDPGFIDLAFSKKKADDRKEWLRGFEPGVHLDPDLSIIPISDFINKELILFSM 750

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
            AD  RSIPS++DG KP QRKIL+  +K+ L  EIKV Q  GY+ EHSAYHHG+QSL  +I
Sbjct: 751  ADNIRSIPSMLDGFKPSQRKILYGCYKRNLRSEIKVSQLAGYIGEHSAYHHGDQSLIQSI 810

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            IG+AQDFVGSNN+NLL+P G FG+R  GGKD +++RYI+T+L+ ITR +FH +D+ LL Y
Sbjct: 811  IGLAQDFVGSNNLNLLQPIGGFGSRAQGGKDASAARYIFTDLSKITRKIFHVDDNPLLNY 870

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            L +D +++EP WY+PI+P++L+NGSEGIGTGWS+ IP +NP DI+AN+RRL++ + M  M
Sbjct: 871  LQDDEQTVEPEWYLPIVPMLLINGSEGIGTGWSTNIPPFNPVDIVANIRRLMDGQEMEEM 930

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PWYRG+ G I K + +  + + G +E+ID+++  ITE+P + WT + K+FL +   GS 
Sbjct: 931  IPWYRGWNGSITKISAD-KFRMEGNIEQIDDETIEITEIPAKTWTINMKEFLLNGIAGSE 989

Query: 547  NVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEG 606
              K  + +   Q+G D  +   I +  E++   +Q GL ++FKL TTI+  NM  FDA G
Sbjct: 990  KQKSWIKDMEEQHGMD--LKFVITLTKEEMKKSLQMGLKERFKLITTINVGNMVAFDAAG 1047

Query: 607  KIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSN 666
            KIKKY+N  +I+E+++ +RLD+Y+RRK ++ E     L  + ++ RF+  ++  E+ V+N
Sbjct: 1048 KIKKYDNVNEIIEDYYHVRLDFYQRRKDHLAEVLGNQLEKISSQARFVKMIIENELRVNN 1107

Query: 667  RKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKR--- 723
            RK+ +L+ ELQ+  F    K GK    QV                           +   
Sbjct: 1108 RKRIELIEELQRLNFPKFSKDGKPIWQQVDQEEITEAEIKVEEEEEEEIDDENLLNKSVN 1167

Query: 724  --GDYEYLLSMSIGTLTLE 740
                Y+YLL M I +LT E
Sbjct: 1168 IFASYDYLLGMPIWSLTRE 1186


>E7R9F3_PICAD (tr|E7R9F3) DNA topoisomerase 2 OS=Pichia angusta (strain ATCC 26012
            / NRRL Y-7560 / DL-1) GN=HPODL_3226 PE=3 SV=1
          Length = 1372

 Score =  721 bits (1861), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 360/735 (48%), Positives = 494/735 (67%), Gaps = 12/735 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SGIL++++  A     K LKK DG++  RL G  KLEDAN AG +   KCTLILTEG
Sbjct: 435  VLASGILESVMDIAQANADKALKKNDGSRKSRLTGYPKLEDANKAGTKEGHKCTLILTEG 494

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA+AGL+VVGRD+YG +PLRGK+LNVREAS  QIM N EIQ IK+I+GLQ  K Y
Sbjct: 495  DSAKSLAVAGLAVVGRDYYGCYPLRGKMLNVREASTDQIMKNAEIQAIKQIMGLQHKKRY 554

Query: 133  --SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
              SN+ +LRYGH+MIM+DQDHDGSHIKGL+INF+ + +P LL++P F++EF TPI++   
Sbjct: 555  DLSNINTLRYGHIMIMSDQDHDGSHIKGLIINFLETSFPGLLEIPGFLIEFITPIVKVTI 614

Query: 191  SNG----TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
              G     K+SF++MPEYE WR+ +G   + +K KYYKGLGTS P E REYF  L +H K
Sbjct: 615  LTGPDKNKKISFFNMPEYEEWRDTIGKTCS-YKQKYYKGLGTSLPTEMREYFSQLDRHLK 673

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
             F    + D S I++AFSKKKA+DRK W+R F+PG + D   + I   +F+NKELILFS 
Sbjct: 674  TFHTLQEEDVSLIDLAFSKKKADDRKEWLRGFQPGTFLDPNLTEIPISEFINKELILFSM 733

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
            AD  RSIPSV+DG KP QRK+L+  +K+ L  EIKV Q +GY+ EHS YHHGE SL  TI
Sbjct: 734  ADNIRSIPSVMDGFKPTQRKVLYGVYKRNLTSEIKVAQLVGYIGEHSGYHHGEASLTQTI 793

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            I +AQDFVGSNN+N+LKPNG FG+R  GGKD +++RYI+TE+ PITR +++  D+ LL Y
Sbjct: 794  ISLAQDFVGSNNLNILKPNGGFGSRASGGKDASAARYIFTEVTPITRKVYNTLDNPLLNY 853

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            L +D +++EP WY+P++P++LVNGSEGIG+GWS+ IP +NP DI+ N+R L+N E MV M
Sbjct: 854  LQDDEQTVEPQWYVPVLPMILVNGSEGIGSGWSTQIPPFNPVDIVKNIRALMNGEEMVDM 913

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PW++G++G I +   +  + + G +EEID+ +  ITELP R WT   K+FL     GS 
Sbjct: 914  IPWFKGWEGTISRIGPD-KFRMEGNIEEIDDTTVEITELPARMWTITMKEFLLQAIAGSD 972

Query: 547  NVKDPLIEDF-RQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P I+D   Q+G    +   + +  E++    + GL ++FKL + I+TSNM  FD +
Sbjct: 973  KQK-PWIKDMEEQHG--VGIKFVVTLSKEEMEKTRRIGLKERFKLISIINTSNMVAFDPQ 1029

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+IKKY++  QI+E+++ +RLDYY+RRK Y+ + F      L  + +F+  ++  E+ ++
Sbjct: 1030 GRIKKYDHVNQIIEDYYLVRLDYYQRRKDYMADLFSNQFEKLSYQAKFVKMIIDRELNIN 1089

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
            N+K+ +L+ EL+Q GF    K  K   P                                
Sbjct: 1090 NKKRVNLVKELKQLGFPGFDKHNKPIRPTELKEEDDEEDINELAADPTAVVQEKKTAVSA 1149

Query: 726  YEYLLSMSIGTLTLE 740
            Y+YLL M + +LT E
Sbjct: 1150 YDYLLGMPLWSLTSE 1164


>Q76C30_ARTBE (tr|Q76C30) DNA topoisomerase 2 (Fragment) OS=Arthroderma benhamiae
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  721 bits (1860), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/686 (51%), Positives = 477/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 552

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHSKSFFTIPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH  D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHPADEPLLVNNV 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP +++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKGEVTGSGDR--YKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1027 KKAVLIQELQEKGFKPFPKVVGTPEP 1052


>I8I908_ASPO3 (tr|I8I908) DNA topoisomerase 2 OS=Aspergillus oryzae (strain 3.042)
            GN=Ao3042_10310 PE=3 SV=1
          Length = 1730

 Score =  720 bits (1859), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 371/748 (49%), Positives = 498/748 (66%), Gaps = 28/748 (3%)

Query: 3    FYTYMLQMFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNS 62
            FY  +L+      + ++  +L +A  K  + LKKTDG +  R+    KL DAN AG ++ 
Sbjct: 497  FYKKILK------TDVMSNILHFAQQKADQMLKKTDGGRRARMNN-PKLTDANKAGTKDG 549

Query: 63   DKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKK 122
              CTLILTEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+A+ +QI  N EIQNIK 
Sbjct: 550  HHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDATFEQISKNAEIQNIKN 609

Query: 123  ILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFT 182
             LGLQ  KEY++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLL++P F++EF 
Sbjct: 610  FLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLRIPEFLIEFI 669

Query: 183  TPIIRAFHS---NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYF 238
            TPII+ +     N TK  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YF
Sbjct: 670  TPIIKVWKGDPKNPTKQRSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYF 728

Query: 239  RDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVN 298
            RDL +H K+F    D +   IE+AFSKKKA++RK W+R F+PG + DH  S+I+Y DF+N
Sbjct: 729  RDLDRHLKEFHTMQDNEVGLIELAFSKKKADERKEWLRQFKPGTFLDHSVSKISYTDFIN 788

Query: 299  KELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHG 358
            KELILFS AD  RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG
Sbjct: 789  KELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHG 848

Query: 359  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHE 418
            + SL  TI+G+AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH 
Sbjct: 849  DISLQQTIVGLAQSFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRVFHA 908

Query: 419  NDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL 478
            +DD LL Y  +DG  IEP  Y+P++P++LVNG++GIGTGWSS IPNYNP DI+ N++RL+
Sbjct: 909  HDDPLLTYNEDDGEKIEPEIYVPVVPMILVNGADGIGTGWSSSIPNYNPEDIVDNLKRLM 968

Query: 479  NDETMVPMDPWYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQ 536
            + E   PM PW+RGF G +      GG  +  +G ++E  E+   ITELPIR WTQD+K 
Sbjct: 969  DGEETRPMQPWFRGFTGEV---TDVGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKD 1025

Query: 537  FLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTIS 595
             LE I       K P  I+D++       V   I++  + +   + EGL +KFKL+ T++
Sbjct: 1026 KLEDIIKAE---KTPSFIKDYKDYNTHTKVHFVIQLDEKNMKSALSEGLEEKFKLSKTVA 1082

Query: 596  TSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFIL 655
            T+N+  FD EG+I KY   + IL+EF+  RL +YE+RKQY L   ++ L  L N+ RF+ 
Sbjct: 1083 TTNLVAFDPEGRITKYATVDDILKEFYTYRLKFYEKRKQYQLSQLQKELDKLSNQARFVQ 1142

Query: 656  GVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXX 715
             ++ G++VVS +KK  L+ EL+ KG+   P   K AE   AG                  
Sbjct: 1143 EIIDGKLVVSKKKKNVLVQELKDKGYKAFP---KVAEAVKAGEEERVVEEDDDESDSQDT 1199

Query: 716  XXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                      Y+YLL M+I +LT E V+
Sbjct: 1200 EVLSSA----YDYLLGMAIWSLTQERVE 1223


>C5P1Z4_COCP7 (tr|C5P1Z4) DNA topoisomerase 2 OS=Coccidioides posadasii (strain
            C735) GN=CPC735_036030 PE=3 SV=1
          Length = 1717

 Score =  720 bits (1859), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 344/685 (50%), Positives = 483/685 (70%), Gaps = 12/685 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + ++  ++ +A+ K  + LKKTDG++  R+    KL DAN AG +    CTLILTEG
Sbjct: 510  ILKTQVMQNIMHFAEQKADQILKKTDGSRRARMNN-PKLTDANKAGTKEGHHCTLILTEG 568

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK  LGLQ  KEY
Sbjct: 569  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNQEIQNIKNFLGLQHKKEY 628

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +PSLLK+P F++EF TPI++ +  +
Sbjct: 629  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPSLLKIPGFLIEFITPIVKVWKGD 688

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+++ G++   W  KYYKGLGTS+ ++   YFRDL +H K+F
Sbjct: 689  PKNPTASKSFFTLPEYEEWKKSHGHDRR-WDKKYYKGLGTSSTEDAEVYFRDLDRHLKEF 747

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   I++AFSKKKA+DRK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 748  HAMQDTEAQLIDLAFSKKKADDRKEWLRQFKPGTYLDHSVDKITYTDFINKELILFSMAD 807

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HGE SL  TI+G
Sbjct: 808  NIRSIPSVVDGLKPGQRKVLYAMFKRNVKKDMKVVELGGYVSGMTAYQHGEASLQQTIVG 867

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYI+T L+P  R +FH  D+ LL+   
Sbjct: 868  LAQTFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIHTRLSPFARRIFHAADEPLLKSNI 927

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++P++L+NG++GIGTGWS+ IPN+NP D++AN+RRL++ E++VPM P
Sbjct: 928  DDGKVIEPEVYVPVVPMILINGADGIGTGWSTSIPNFNPEDVVANLRRLMDGESLVPMKP 987

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G  E +A    Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 988  WFRGFTG--EVTASGDRYKFSGIIKQTGDCEVEITELPIRTWTQDFKDKLEEIIKAE--- 1042

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++     + V   I+M  + +   +++GL ++FKL+ TI+T+NM  FDAEG+
Sbjct: 1043 KAPSFIKDYKDYNTHSKVHFIIQMDEKHMKKALEDGLEERFKLSKTIATTNMVAFDAEGR 1102

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY+  E IL+ F+ +R+ +YE+RKQ++L    + L    N+ RF+  ++ G++V+S +
Sbjct: 1103 ITKYDTAEDILKAFYAVRIRFYEKRKQHLLAQLHKELDKFTNQARFVQMIIDGKLVISKK 1162

Query: 668  KKADLLMELQQKGFTPMPKKGKSAE 692
            +K  L+ EL++KGF P+PK   +A+
Sbjct: 1163 RKPKLIEELKEKGFKPIPKAVDAAK 1187


>E9DFV8_COCPS (tr|E9DFV8) DNA topoisomerase 2 OS=Coccidioides posadasii (strain
            RMSCC 757 / Silveira) GN=CPSG_08707 PE=3 SV=1
          Length = 1717

 Score =  720 bits (1858), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 344/685 (50%), Positives = 483/685 (70%), Gaps = 12/685 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + ++  ++ +A+ K  + LKKTDG++  R+    KL DAN AG +    CTLILTEG
Sbjct: 510  ILKTQVMQNIMHFAEQKADQILKKTDGSRRARMNN-PKLTDANKAGTKEGHHCTLILTEG 568

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N+EIQNIK  LGLQ  KEY
Sbjct: 569  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNQEIQNIKNFLGLQHKKEY 628

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +PSLLK+P F++EF TPI++ +  +
Sbjct: 629  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPSLLKIPGFLIEFITPIVKVWKGD 688

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+++ G++   W  KYYKGLGTS+ ++   YFRDL +H K+F
Sbjct: 689  PKNPTASKSFFTLPEYEEWKKSHGHDRR-WDKKYYKGLGTSSTEDAEVYFRDLDRHLKEF 747

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   I++AFSKKKA+DRK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 748  HAMQDTEAQLIDLAFSKKKADDRKEWLRQFKPGTYLDHSVDKITYTDFINKELILFSMAD 807

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  GYVS  +AY HGE SL  TI+G
Sbjct: 808  NIRSIPSVVDGLKPGQRKVLYAMFKRNVKKDMKVVELGGYVSGMTAYQHGEASLQQTIVG 867

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYI+T L+P  R +FH  D+ LL+   
Sbjct: 868  LAQTFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIHTRLSPFARRIFHAADEPLLKSNI 927

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++P++L+NG++GIGTGWS+ IPN+NP D++AN+RRL++ E++VPM P
Sbjct: 928  DDGKVIEPEVYVPVVPMILINGADGIGTGWSTSIPNFNPEDVVANLRRLMDGESLVPMKP 987

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G  E +A    Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 988  WFRGFTG--EVTASGDRYKFSGIIKQTGDCEVEITELPIRTWTQDFKDKLEEIIKAE--- 1042

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++     + V   I+M  + +   +++GL ++FKL+ TI+T+NM  FDAEG+
Sbjct: 1043 KAPSFIKDYKDYNTHSKVHFIIQMDEKHMKKALEDGLEERFKLSKTIATTNMVAFDAEGR 1102

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY+  E IL+ F+ +R+ +YE+RKQ++L    + L    N+ RF+  ++ G++V+S +
Sbjct: 1103 ITKYDTAEDILKAFYAVRIRFYEKRKQHLLAQLHKELDKFTNQARFVQMIIDGKLVISKK 1162

Query: 668  KKADLLMELQQKGFTPMPKKGKSAE 692
            +K  L+ EL++KGF P+PK   +A+
Sbjct: 1163 RKPKLIEELKEKGFKPIPKAVDAAK 1187


>C0SGV5_PARBP (tr|C0SGV5) DNA topoisomerase 2 OS=Paracoccidioides brasiliensis
            (strain Pb03) GN=PABG_06827 PE=3 SV=1
          Length = 1788

 Score =  720 bits (1858), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 362/736 (49%), Positives = 488/736 (66%), Gaps = 16/736 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + +++ ++ +A+ K  + LKK+DG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 515  VIKTQVMENIMHFAEKKADQILKKSDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 573

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG ++VG D +GVFPLRGK+LNVR+AS  QI  N EIQNIK  LGLQ  KEY
Sbjct: 574  DSAKGLAMAGRAIVGPDLFGVFPLRGKMLNVRDASVDQISKNAEIQNIKNFLGLQHKKEY 633

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF+   +PSLLK+P F++EF TPI++ +  +
Sbjct: 634  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFLQVAFPSLLKIPQFLIEFITPIVKVWKGD 693

Query: 193  G----TKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF++M EYE+W+E  G++   W+ KYYKGLGTST ++   YF+DL KH K F
Sbjct: 694  PKNPIISKSFFTMQEYETWKEIHGHDRR-WEKKYYKGLGTSTTEDAEIYFQDLDKHLKQF 752

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   I++AFSKKKA++RK W+R F+PG + DH    I Y DF+NKELILFS AD
Sbjct: 753  HVMQDNEAQLIDLAFSKKKADERKEWLRQFKPGTFLDHTTEEITYTDFINKELILFSMAD 812

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL  TI+G
Sbjct: 813  NIRSIPSVVDGLKPGQRKVLYTCFKRNVRKDIKVVELAGYVSGMTAYQHGDVSLQQTIVG 872

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH  D+ LL Y  
Sbjct: 873  LAQTFVGSNNVNCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRIFHPADEPLLTYNV 932

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG +IEP  Y+P++PLVL+NG++GIGTGWS+ IPNYNP DI+AN++ L++ E +VPM P
Sbjct: 933  DDGHTIEPEIYVPVVPLVLINGADGIGTGWSTSIPNYNPEDIVANLKCLMDGEPLVPMQP 992

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     E  Y  +G + ++ E    ITELPIR WTQD+K  LE I       
Sbjct: 993  WFRGFTGEVVSLGGE-RYKFSGRISQVGENEVEITELPIRCWTQDFKDRLEEIIKAE--- 1048

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I++  +  A  + EGL +KFKL+ TI+TSN+  FD EG+
Sbjct: 1049 KVPSFIKDYKDYNTHTKVHFVIQLDEKHAAKAIAEGLEEKFKLSKTIATSNLVAFDPEGR 1108

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY++PE IL EF+ +R+ +YE+RKQY L   +R L  L N+ RFI  ++ G++V+S +
Sbjct: 1109 ITKYDSPEDILREFYSVRIKFYEKRKQYQLSQLQRDLDKLSNQARFIQMIIDGKLVISKK 1168

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
             KA L+ EL++KGF    K   +A+     +                           Y+
Sbjct: 1169 PKAKLIQELKEKGFKAFSKISDAAK-----SGETAPVVEEDDNEEKSDSDDAELGADSYD 1223

Query: 728  YLLSMSIGTLTLESVQ 743
            YL +M + +LT E V+
Sbjct: 1224 YLFAMPLWSLTQERVE 1239


>Q8J2R6_EPIFL (tr|Q8J2R6) DNA topoisomerase 2 (Fragment) OS=Epidermophyton
            floccosum GN=top2 PE=3 SV=1
          Length = 1091

 Score =  719 bits (1857), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/686 (51%), Positives = 476/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 374  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGYHCTLILTEG 432

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 433  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 492

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 493  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 552

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W++   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 553  PKNPTHSKSFFTLPEYEEWKKTHAHDKR-WQKKYYKGLGTSSTEDAQIYFQDLDRHLKQF 611

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH    I Y DF+NKELILFS AD
Sbjct: 612  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDHITYTDFINKELILFSMAD 671

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 672  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 731

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 732  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 791

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  E +VPM P
Sbjct: 792  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGEELVPMKP 851

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I       
Sbjct: 852  WFRGFKGEVTGSGDR--YKFSGIIKQTGDSEVEITELPIRTWTQDFKDKLEEIIKAE--- 906

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 907  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGR 966

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQY+L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 967  ITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTRLDKLSNQARFVQMIIDGKLVISKK 1026

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1027 KKALLIQELQEKGFKPFPKVVDNREP 1052


>Q5CQG8_CRYPI (tr|Q5CQG8) DNA topoisomerase 2 OS=Cryptosporidium parvum (strain
            Iowa II) GN=cgd4_780 PE=3 SV=1
          Length = 1797

 Score =  719 bits (1856), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/749 (50%), Positives = 492/749 (65%), Gaps = 85/749 (11%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKK-----TDGTKTQRLRGIVKLEDANDAGGRNSDKCT 66
            +V  S I++ +L WA  KQS +LKK        T T RL GI KLEDAN+AGG +S KCT
Sbjct: 522  SVVKSSIVENVLMWAQLKQSMELKKKMKSNQKNTVTSRLLGIPKLEDANEAGGPHSKKCT 581

Query: 67   LILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGL 126
            LILTEGDSAK   +AGLS+VGRD++GVFPLRGKLLNVREAS KQ + N EIQNI KILGL
Sbjct: 582  LILTEGDSAKTSCLAGLSIVGRDYFGVFPLRGKLLNVREASFKQQIGNVEIQNILKILGL 641

Query: 127  QQNKEYSNVK-SLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPI 185
               ++Y N   +LRYG LM+M DQDHDGSHIKGL+IN IH +WPSL+    F+ +F TPI
Sbjct: 642  GIGQKYDNGPVNLRYGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLIHFRGFLKQFVTPI 701

Query: 186  IRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHR 245
            ++A      ++SF+++ EYE WR+N  +N  GW+ KYYKGLGTST  E +EYF  +  H 
Sbjct: 702  VKA-KKGSNEISFFTLYEYEQWRKNNSSNLNGWRFKYYKGLGTSTDLEFKEYFTKIENHS 760

Query: 246  KDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHV----ASRINYKDFVNKEL 301
             +F W DD D  AI+MAFSKK+ EDRK WI +++ G Y D+        + Y DF++KEL
Sbjct: 761  IEFDWMDDQDDEAIDMAFSKKRTEDRKNWIESYKEGTYVDYSINNQCRNLRYFDFIHKEL 820

Query: 302  ILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQS 361
            +LFSR D  RSIP+++DGLKPGQRK+LF +FKKKL  E+KV Q  GYV+EHSAYHHGE S
Sbjct: 821  VLFSRYDTTRSIPNLLDGLKPGQRKVLFATFKKKLNNELKVAQLAGYVAEHSAYHHGESS 880

Query: 362  LASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDD 421
            L STI+ MAQ+FVGSNN+NLL+P GQFG+R  GGKD +++RYI+T+L+  TR +F E DD
Sbjct: 881  LQSTIVNMAQNFVGSNNLNLLEPCGQFGSRKEGGKDASAARYIFTKLSKWTRYIFPEADD 940

Query: 422  KLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDE 481
             LL YL +DG+ IEP +Y+PIIP++LVNG++GIGTGWSS +PNYNP+DII N++R+L  E
Sbjct: 941  PLLTYLYDDGQQIEPLYYVPIIPMILVNGTDGIGTGWSSSVPNYNPKDIIMNLKRMLKGE 1000

Query: 482  TMVPMDPWYRGFKGII--------EKSAKEGG---------------------------- 505
             MVPM PWY+ FKG I        + SA  GG                            
Sbjct: 1001 MMVPMTPWYKSFKGKIFPIKQKSKKNSASNGGGNNNRKKTAINSFNNGSNSSILIGSQVD 1060

Query: 506  -------------YIVNGTVEEI----------------DEQSFRITELPIRKWTQDYKQ 536
                          + NG +EE                 +E++  ITELP+R+WTQDYK+
Sbjct: 1061 AEDDDLQQIQRTNNMGNGIIEETLELGANYETFGNWYKKNEETLVITELPVRRWTQDYKE 1120

Query: 537  FLESITDGSPNVKDPLIE-----DFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLT 591
            +LES    +PN  +  IE     D+R N     V I +RM+ EK+     EG+ K F+L 
Sbjct: 1121 WLESTLLPAPNADNDNIENSWIIDYRDNSSHESVHITVRMRPEKLQQAEMEGIEKIFRLK 1180

Query: 592  TTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILE--NFERLLLVLDN 649
            +T+STSNM LFD   +I +YE    IL+EF P+RL+ YE+RK Y+L   N+E+ L  L+ 
Sbjct: 1181 STLSTSNMTLFDHNSRIVRYETELDILKEFIPIRLEMYEKRKNYLLSKLNYEKCL--LEQ 1238

Query: 650  KVRFILGVVSGEIVVSNRKKADLLMELQQ 678
            K+ F+  V+ G I +SN+ K  L+ +L++
Sbjct: 1239 KILFLKLVIQGVIGLSNKSKETLVSDLKK 1267


>I7M5X3_TETTS (tr|I7M5X3) DNA topoisomerase 2 OS=Tetrahymena thermophila (strain
            SB210) GN=TTHERM_00825440 PE=3 SV=1
          Length = 1416

 Score =  719 bits (1856), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/679 (53%), Positives = 492/679 (72%), Gaps = 13/679 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKT-DGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            +  +GI++ ++S A  +Q+  L KT  G K  R+ GI KL+DANDAG   S+ CTLILTE
Sbjct: 382  ILGTGIIEQIVSQAKARQNAKLAKTLKGGKKGRITGIPKLDDANDAGTARSENCTLILTE 441

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN-K 130
            GDSAKALAMAG+ VVGRD+YGVFPL+GKLLNVREA+ KQI++N+EIQNI KI+GL    +
Sbjct: 442  GDSAKALAMAGIEVVGRDNYGVFPLKGKLLNVREANKKQIIENQEIQNICKIIGLDPAVQ 501

Query: 131  EYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
             Y N K LRYG LMIMADQD DGSHIKGL+INFIH FWPSL K+  F+ EF TPI++   
Sbjct: 502  NYENTKQLRYGSLMIMADQDSDGSHIKGLVINFIHHFWPSLFKMKGFLKEFITPILKVTK 561

Query: 191  SNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             +    SF+++ +++++    G+    +K+KYYKGLGTST +E +EYF +  KH+ +F +
Sbjct: 562  GDEVH-SFFTIQDFKNFAAQKGDRLKQYKVKYYKGLGTSTDKEAKEYFSNFYKHQINFQY 620

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
             D+ D  AIE+ FS KK ++RK W+ N++P ++ D+   ++ YKDF+++ELI FS AD  
Sbjct: 621  LDENDMEAIELGFSGKKIKERKDWLANYDPNSFVDYNIKQLRYKDFIDRELIHFSNADNL 680

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPS+ DGLKPGQRKILF  FK+ L  EIKV Q IGYV+EHSAYHHGEQSLASTIIGMA
Sbjct: 681  RSIPSLCDGLKPGQRKILFSCFKRNLKSEIKVAQLIGYVAEHSAYHHGEQSLASTIIGMA 740

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q+FVGSNNINL+ P GQFGTRN GGK+HAS+RYI+T L+ ITR LF E+DD +L+YL +D
Sbjct: 741  QNFVGSNNINLMMPIGQFGTRNQGGKEHASARYIFTSLSKITRILFPEHDDHVLKYLEDD 800

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
             + +EP WY+PIIP+ LVNGS GIGTGWS+ IPNYN ++I+  +R  L  +    + PWY
Sbjct: 801  NQVVEPEWYMPIIPMCLVNGSSGIGTGWSTDIPNYNHKEIVEQIRGKLEGKPFTELHPWY 860

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEID--EQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            +GF+G IE + K GGYIV G   EID  E++ +ITELP+ KWT+DYK +LE +   SP  
Sbjct: 861  KGFQGQIEINPK-GGYIVKGQY-EIDEVEETIKITELPVGKWTRDYKNYLEELL--SPPK 916

Query: 549  KDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEG-LLKKFKLTTTISTSNMHLFDAEGK 607
             +P IED R+   +  V  E++        I Q G + KK KL+TT+ T+N+ +F+ + K
Sbjct: 917  GEPEIEDIREYHTNNRVHFEVQAIP---GRIQQWGDIEKKLKLSTTMQTTNIVMFNDKYK 973

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            +K+Y++  +I+EEF+ LRL  Y++RK Y++   +R + +L NK++FI  VV+G + + N 
Sbjct: 974  LKRYQSTVEIMEEFYALRLKCYQKRKDYLVSKIQRDVDILQNKMKFITLVVNGTLEIRNA 1033

Query: 668  KKADLLMELQQKGFTPMPK 686
            +K  +L +L++ G TPM K
Sbjct: 1034 RKKGVLNKLKELGLTPMSK 1052


>Q8J2R7_ARTGY (tr|Q8J2R7) DNA topoisomerase 2 (Fragment) OS=Arthroderma gypseum
            GN=top2 PE=3 SV=1
          Length = 1091

 Score =  719 bits (1855), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/686 (51%), Positives = 477/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 375  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 433

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 434  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 493

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 494  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 553

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 554  PKNPTHSKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQVYFQDLDRHLKQF 612

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 613  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSMDQITYTDFINKELILFSMAD 672

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 673  NIRSIPSVVDGLKPGQRKVLYTMFKRNVKKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 732

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 733  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLANNV 792

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  + +VPM P
Sbjct: 793  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGDELVPMKP 852

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    I+ELPIR WTQD+K  LE I       
Sbjct: 853  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEISELPIRTWTQDFKDKLEEIIKAE--- 907

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 908  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKAVEEGLEEKFKLVKPIATSNMVAFDAEGR 967

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 968  ITRYETPEDILRAFYAVRIKLYEKRKQHLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1027

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1028 KKALLIQELQEKGFKPFPKVVDTPEP 1053


>Q76C41_ARTGY (tr|Q76C41) DNA topoisomerase 2 (Fragment) OS=Arthroderma gypseum
            GN=top2 PE=3 SV=1
          Length = 1086

 Score =  718 bits (1854), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/686 (51%), Positives = 477/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 372  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 430

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 431  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 490

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 491  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 550

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 551  PKNPTHSKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQVYFQDLDRHLKQF 609

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 610  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSMDQITYTDFINKELILFSMAD 669

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 670  NIRSIPSVVDGLKPGQRKVLYTMFKRNVKKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 729

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 730  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 789

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  + +VPM P
Sbjct: 790  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGDELVPMKP 849

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    I+ELPIR WTQD+K  LE I       
Sbjct: 850  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEISELPIRTWTQDFKDKLEEIIKAE--- 904

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 905  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKAVEEGLEEKFKLVKQIATSNMVAFDAEGR 964

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 965  ITRYETPEDILRAFYAVRIKLYEKRKQHLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1024

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1025 KKALLIQELQEKGFKPFPKVVDTPEP 1050


>Q2TY87_ASPOR (tr|Q2TY87) DNA topoisomerase 2 OS=Aspergillus oryzae (strain ATCC
            42149 / RIB 40) GN=AO090103000347 PE=3 SV=1
          Length = 1437

 Score =  718 bits (1854), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/738 (49%), Positives = 494/738 (66%), Gaps = 22/738 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + ++  +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 393  ILKTDVMSNILHFAQQKADQMLKKTDGGRRARMNN-PKLTDANKAGTKDGHHCTLILTEG 451

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+A+ +QI  N EIQNIK  LGLQ  KEY
Sbjct: 452  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDATFEQISKNAEIQNIKNFLGLQHKKEY 511

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLL++P F++EF TPII+ +   
Sbjct: 512  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLRIPEFLIEFITPIIKVWKGD 571

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 572  PKNPTKQRSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 630

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG + DH  S+I+Y DF+NKELILFS AD
Sbjct: 631  HTMQDNEVGLIELAFSKKKADERKEWLRQFKPGTFLDHSVSKISYTDFINKELILFSMAD 690

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 691  NVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHGDISLQQTIVG 750

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH +DD LL Y  
Sbjct: 751  LAQSFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRVFHAHDDPLLTYNE 810

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++P++LVNG++GIGTGWSS IPNYNP DI+ N++RL++ E   PM P
Sbjct: 811  DDGEKIEPEIYVPVVPMILVNGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGEETRPMQP 870

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  +  +G ++E  E+   ITELPIR WTQD+K  LE I     
Sbjct: 871  WFRGFTGEV---TDVGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKDKLEDIIKAE- 926

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D++       V   I++  + +   + EGL +KFKL+ T++T+N+  FD E
Sbjct: 927  --KTPSFIKDYKDYNTHTKVHFVIQLDEKNMKSALSEGLEEKFKLSKTVATTNLVAFDPE 984

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EF+  RL +YE+RKQY L   ++ L  L N+ RF+  ++ G++VVS
Sbjct: 985  GRITKYATVDDILKEFYTYRLKFYEKRKQYQLSQLQKELDKLSNQARFVQEIIDGKLVVS 1044

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
             +KK  L+ EL+ KG+   P   K AE   AG                            
Sbjct: 1045 KKKKNVLVQELKDKGYKAFP---KVAEAVKAGEEERVVEEDDDESDSQDTEVLSSA---- 1097

Query: 726  YEYLLSMSIGTLTLESVQ 743
            Y+YLL M+I +LT E V+
Sbjct: 1098 YDYLLGMAIWSLTQERVE 1115


>Q8X1U6_ASPFL (tr|Q8X1U6) DNA topoisomerase 2 (Fragment) OS=Aspergillus flavus
            GN=TOP 2 PE=3 SV=1
          Length = 1219

 Score =  718 bits (1853), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/738 (49%), Positives = 494/738 (66%), Gaps = 22/738 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + ++  +L +A  K  + LKKTDG +  R+    KL DAN AG ++   CTLILTEG
Sbjct: 399  ILKTDVMSNILHFAQQKADQMLKKTDGGRRARMNN-PKLTDANKAGTKDGHHCTLILTEG 457

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+A+ +QI  N EIQNIK  LGLQ  KEY
Sbjct: 458  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDATFEQISKNAEIQNIKNFLGLQHKKEY 517

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLL++P F++EF TPII+ +   
Sbjct: 518  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLRIPEFLIEFITPIIKVWKGD 577

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 578  PKNPTKQRSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 636

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG + DH  S+I+Y DF+NKELILFS AD
Sbjct: 637  HTMQDNEVGLIELAFSKKKADERKEWLRQFKPGTFLDHSVSKISYTDFINKELILFSMAD 696

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 697  NVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHGDISLQQTIVG 756

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH +DD LL Y  
Sbjct: 757  LAQSFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRVFHAHDDPLLTYNE 816

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++P++LVNG++GIGTGWSS IPNYNP DI+ N++RL++ E   PM P
Sbjct: 817  DDGEKIEPEIYVPVVPMILVNGADGIGTGWSSSIPNYNPEDIVDNLKRLMDGEETRPMQP 876

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  +  +G ++E  E+   ITELPIR WTQD+K  LE I     
Sbjct: 877  WFRGFTGEV---TDVGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKDKLEDIIKAE- 932

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D++       V   I++  + +   + EGL +KFKL+ T++T+N+  FD E
Sbjct: 933  --KTPSFIKDYKDYNTHTKVHFVIQLDEKNMKSALSEGLEEKFKLSKTVATTNLVAFDPE 990

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EF+  RL +YE+RKQY L   ++ L  L N+ RF+  ++ G++VVS
Sbjct: 991  GRITKYATVDDILKEFYTYRLKFYEKRKQYQLSQLQKELDKLSNQARFVQEIIDGKLVVS 1050

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
             +KK  L+ EL+ KG+   P   K AE   AG                            
Sbjct: 1051 KKKKNVLVQELKDKGYKAFP---KVAEAVKAGEEERVVEEDDDESDSQDTEVLSSA---- 1103

Query: 726  YEYLLSMSIGTLTLESVQ 743
            Y+YLL M+I +LT E V+
Sbjct: 1104 YDYLLGMAIWSLTQERVE 1121


>Q4Z0B9_PLABA (tr|Q4Z0B9) DNA topoisomerase 2 (Fragment) OS=Plasmodium berghei
            (strain Anka) GN=PB000671.01.0 PE=3 SV=1
          Length = 1092

 Score =  717 bits (1851), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 356/658 (54%), Positives = 472/658 (71%), Gaps = 13/658 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKT----DGTKTQRLRGIVKLEDANDAGGRNSDKCTLI 68
            V  S IL  +L WA  K   +L+K          +R+ GI KLEDANDAG + S +CTLI
Sbjct: 443  VLKSSILSNILLWAQAKAQVELRKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLI 502

Query: 69   LTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQ- 127
            LTEGDSAK   +AGLS+VGRD YGVFPL+GKLLNVR+AS KQ+MDN+EIQNI KI+GL  
Sbjct: 503  LTEGDSAKTSCLAGLSIVGRDRYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFKIMGLDI 562

Query: 128  QNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             +K   ++K LRYG LMI  DQD+DGSHIKGLLIN IH FWPSLLK   F+ EF TPI++
Sbjct: 563  TDKNKQDIKGLRYGSLMI-TDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLCEFVTPIVK 621

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                N  +LSF+++ EYE W+EN   N  GWKIKYYKGLGTST +E ++YF D+  H+  
Sbjct: 622  VQKGN-QELSFFTIAEYEQWKEN--TNLVGWKIKYYKGLGTSTDKEFKQYFSDIQSHKIV 678

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F+W  D DG +I+MAFSKK+ EDRK+W++NF  G+Y DH    ++Y DFVNKELI +SR 
Sbjct: 679  FLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRY 738

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D +RSIP+++DG KPGQRK+L+  FK+ L  E KV Q +GY++EHSAYHHGE SL  TII
Sbjct: 739  DTERSIPNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTII 798

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
             MAQ FVGSNNIN L+P GQFG+R  GGKD +++RYI+T+L   TR +F+E DD +L+YL
Sbjct: 799  NMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYL 858

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
            NE+G+ IEP +YIP+IP +LVNG EGIGTG+SS+IPNYN +DII N+++ ++ E +VPM 
Sbjct: 859  NEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIINNIKKYIDKEPLVPMV 918

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWY+ FKG IE + K  GY   G + +ID+++  ITELPI++WTQDYK+FLE +     +
Sbjct: 919  PWYKDFKGRIEPNGK-SGYETIGIINKIDDETLEITELPIKRWTQDYKEFLEELL---TD 974

Query: 548  VKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
             K+ LI D+  N     V   I+M   K+    +EGL K FKL +T++T+NM LFD   K
Sbjct: 975  EKNQLIIDYIDNSSHEDVCFTIKMDPTKLKRAEEEGLEKVFKLKSTLTTTNMTLFDPNLK 1034

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            +++Y +   IL++F   RL+ Y  RK Y++   E+   ++ NK +FIL +++GE+VV+
Sbjct: 1035 LQRYASELDILKDFCFHRLNAYTDRKNYLISKLEKEKRIISNKAKFILAIINGELVVN 1092


>H8ZD93_NEMS1 (tr|H8ZD93) DNA topoisomerase 2 OS=Nematocida sp. 1 (strain ERTm2 /
            ATCC PRA-371) GN=NERG_01564 PE=3 SV=1
          Length = 1186

 Score =  717 bits (1851), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/757 (48%), Positives = 493/757 (65%), Gaps = 52/757 (6%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  SGI++     A  KQ++ LKKTDG KT +LRGI KL+DAN+AG R + +CTLILTEG
Sbjct: 372  IMRSGIVEKSAYAARAKQTQQLKKTDGHKTSKLRGIPKLDDANNAGTRFASQCTLILTEG 431

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK+LA++GLSV+GRD+YGVFPLRGKLLNVREA++KQ+M+N EI NIKKI+GLQ  KEY
Sbjct: 432  DSAKSLAVSGLSVIGRDNYGVFPLRGKLLNVREATHKQLMENIEINNIKKIMGLQHGKEY 491

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            +  +SLRYGH+MIM DQDHDGSHIKGL+IN I  F+PSLL++  F+ EF TPI+RA   +
Sbjct: 492  ATTESLRYGHIMIMTDQDHDGSHIKGLIINMIDHFFPSLLRIKGFLQEFITPIVRATKGS 551

Query: 193  GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWED 252
             ++  F+++PE+ESW E       GW++KYYKGLGTST ++ ++YF +L  H K+F   D
Sbjct: 552  MSR-DFFTIPEFESWTETAEGRENGWRVKYYKGLGTSTAKDAKDYFSNLDFHIKEFNTVD 610

Query: 253  DYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRS 312
              D   IE+AFSKK+ E RKVW++ F PG Y D+    I+ K+F+++ELI FS AD  RS
Sbjct: 611  SVDRDKIELAFSKKRVESRKVWLKEFVPGTYLDNRVQAISIKNFIDRELIHFSLADNIRS 670

Query: 313  IPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQD 372
            IP+++DG+KPGQRKI+FC FK++L  EIKV Q  GYVSEHSAYHHGEQSL STI+ +AQD
Sbjct: 671  IPNMIDGMKPGQRKIIFCCFKRQLRTEIKVAQLAGYVSEHSAYHHGEQSLCSTIVNLAQD 730

Query: 373  FVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGR 432
            +VGSNNI LL+P GQFGTR  GGKD AS RYI+T L PITR LF E DD LL YL +D  
Sbjct: 731  YVGSNNIPLLQPIGQFGTRLQGGKDAASPRYIFTALQPITRYLFREEDDNLLNYLKDDNL 790

Query: 433  SIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRG 492
             +EP  Y+PIIP+VLVNGS+GIGTGWS+ IP YNP +I+ NV+R++  +    M PWY+G
Sbjct: 791  MVEPDMYVPIIPMVLVNGSDGIGTGWSTCIPPYNPIEIVDNVKRMIMGKEPKEMIPWYKG 850

Query: 493  FKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPL 552
            F G  +     G Y   G  E+ ++    I ELP+  WTQ+YK FLE++ +         
Sbjct: 851  FVGECDDLG-SGKYRTIGAFEQ-EKDKISILELPVGVWTQNYKDFLETLIESGD------ 902

Query: 553  IEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYE 612
            I+DFR+   D  V+ E+      ++   +  + K FKL+  IS +NM  F+++G ++KY 
Sbjct: 903  IKDFREYNTDTRVNFEV-----VVSTKHKINVPKVFKLSNQISIANMVAFNSKGVLQKYA 957

Query: 613  NPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADL 672
            N  +IL+EFF +R D Y RRK ++L+       +L+NKVRFI  VV+  + +  RK +D+
Sbjct: 958  NTTEILKEFFIVRRDLYVRRKDFLLKKLLTETTILENKVRFIKEVVADTLKILKRKSSDV 1017

Query: 673  LMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSM 732
            + +L  K +                                        K   Y+YLL+M
Sbjct: 1018 INDLTAKDY--------------------------------------HKKDNSYDYLLTM 1039

Query: 733  SIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWM 769
             I +LT E ++                 A   + MW+
Sbjct: 1040 QIASLTTERMEKLENEAAGKRSEYIRLKAVSIEDMWL 1076


>R1C6H3_EMIHU (tr|R1C6H3) Putative DNA topoisomerase II OS=Emiliania huxleyi
            CCMP1516 GN=EMIHUDRAFT_451325 PE=4 SV=1
          Length = 1409

 Score =  717 bits (1850), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/812 (46%), Positives = 497/812 (61%), Gaps = 97/812 (11%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N G+L+++LS+A  KQSKDLKKTDGTK  RL GI KL+DAN+AGGRN  KCTLI+TEGDS
Sbjct: 373  NCGVLESILSFAQSKQSKDLKKTDGTKKSRLTGIPKLDDANEAGGRNGSKCTLIITEGDS 432

Query: 75   AKALAMAGLSVVGR---------------------DHYGVFPLRGKLLNVREASNKQIMD 113
            AKALA+AGLS+VGR                     DHYGVFPLRGKLLNVR+A++  IM 
Sbjct: 433  AKALAVAGLSIVGRATACKGCARHPHTGCRTVDRRDHYGVFPLRGKLLNVRDAAHSTIMA 492

Query: 114  NEEIQNIKKILGLQQNKEY---SNVKSLRYGH-------------------------LMI 145
            N+EI  +K+ILGLQQ K Y   +++KSLRYG                          LMI
Sbjct: 493  NKEISELKQILGLQQGKSYDDEASLKSLRYGERRGGDLAAPHPFRAPLTPCPPCAGKLMI 552

Query: 146  MADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK-LSFYSMPEY 204
            M DQDHDGSHIKGL+INF+H +WP+LL+  +    F TPI++A  S G + ++F+++ EY
Sbjct: 553  MTDQDHDGSHIKGLVINFLHCYWPALLQKRAAPARFVTPIVKA--SKGRQAIAFFTLKEY 610

Query: 205  ESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEMAFS 264
            E+WRE  G  A+GW+IKYYKGLGTS+  E + YF DL  H   F W  D D   I  AFS
Sbjct: 611  ENWREEQGAAASGWQIKYYKGLGTSSAAEAKAYFSDLDLHELSFKWTGDADREGIVRAFS 670

Query: 265  KKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLKPGQ 324
            K  A+ RK W+R ++   Y DH  S + Y DFV++ELI FS AD  RSIPS         
Sbjct: 671  KSMADARKEWLRGYDADAYVDHSQSHLTYHDFVDRELIHFSNADNMRSIPSF-------- 722

Query: 325  RKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLKP 384
                          E+KV Q  GY     AYHHGE SL  TI+GMAQ FVGSNNI LL  
Sbjct: 723  --------------EVKVAQLAGY-----AYHHGEASLGGTIVGMAQTFVGSNNIALLHG 763

Query: 385  NGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIP 444
             GQFGTR +GGKD AS RYI+ +L  +TR +FH +DD LLEYL +DG+ IEP +Y+PI+P
Sbjct: 764  AGQFGTRLMGGKDAASPRYIFCKLPQLTRLIFHPHDDALLEYLEDDGQRIEPRYYMPILP 823

Query: 445  LVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSAKEG 504
            +VLVNG++GIGTGWSS +PN+NPRDI+AN+RRL+  E   PM PWYRGF G +  + ++G
Sbjct: 824  MVLVNGADGIGTGWSSSVPNFNPRDIVANLRRLMAGEEPEPMTPWYRGFAGTVTPADQKG 883

Query: 505  GYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ-----FLESITDGSPNVKD--PLIEDFR 557
             Y   G++ + DE++ RI+ELP+RKWTQDYK+      +    DG+    +    + + R
Sbjct: 884  SYSTYGSIAKADERTLRISELPVRKWTQDYKETVLEPMMSDRADGAAKSAELAGALAELR 943

Query: 558  QNGDDAMVDIEIRMKLEKIAMIMQE-GLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQ 616
            +N  D  V   ++   +  A    + GL K  KL+++ISTSNM LFDA+G+I+KYE  E 
Sbjct: 944  ENHTDTTVSFTLKFASDAAAAAANKVGLHKALKLSSSISTSNMTLFDAQGRIQKYEAVEA 1003

Query: 617  ILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMEL 676
            +L +F+ LRL +YE+RK ++ +        LDN++RF+L V+SGE+ ++NRKKADL+ EL
Sbjct: 1004 VLRDFYALRLSFYEKRKLHLQDKLTGEWSKLDNRMRFVLAVISGELKIANRKKADLVAEL 1063

Query: 677  QQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGT 736
             QKG+ P        EP  A                          RG Y+YLLSM + +
Sbjct: 1064 AQKGYAPF-------EP--APKRAAAGDDGEEEAAGEAEGGASASARG-YDYLLSMPLWS 1113

Query: 737  LTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
            LT E V+                 AT  + +W
Sbjct: 1114 LTRERVEQLRGECTAKEAELQTLLATSPRQLW 1145


>Q76C42_9EURO (tr|Q76C42) DNA topoisomerase 2 (Fragment) OS=Arthroderma incurvatum
            GN=top2 PE=3 SV=1
          Length = 1086

 Score =  717 bits (1850), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/686 (51%), Positives = 477/686 (69%), Gaps = 12/686 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 372  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 430

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 431  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 490

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 491  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 550

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E+  ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 551  PKNPTHSKSFFTLPEYEEWKESHAHDKK-WQKKYYKGLGTSSTEDAQVYFQDLDRHLKQF 609

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 610  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSMDQITYTDFINKELILFSMAD 669

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 670  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 729

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 730  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 789

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  + +VPM P
Sbjct: 790  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMVGDELVPMKP 849

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    I+ELPIR WTQD+K  LE I       
Sbjct: 850  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEISELPIRTWTQDFKDKLEDIIKAE--- 904

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   ++EGL +KFKL   I+TSNM  FDAEG+
Sbjct: 905  KVPSFIKDYKDYNTHTNVHFIIQMDEKHMKKAVEEGLEEKFKLVKQIATSNMVAFDAEGR 964

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 965  ITRYETPEDILRAFYTVRIKLYEKRKQHLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1024

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEP 693
            KKA L+ ELQ+KGF P PK   + EP
Sbjct: 1025 KKAILIEELQEKGFKPFPKVIDTREP 1050


>J9IBE1_9SPIT (tr|J9IBE1) DNA topoisomerase 2 OS=Oxytricha trifallax
            GN=OXYTRI_07785 PE=3 SV=1
          Length = 1554

 Score =  716 bits (1849), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/751 (50%), Positives = 498/751 (66%), Gaps = 59/751 (7%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGT--KTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            +A SGI++ +++ A+ K++  LKK  GT  K ++L GI KLEDAN AG   S+ C LILT
Sbjct: 387  IAKSGIIEDIVAKAEMKEAMKLKKELGTGVKKKKLFGIPKLEDANLAGTSESESCILILT 446

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LAM+GL VVGRD +GVFPLRGKLLNVR+   KQI+DNEEIQNI KILGL   +
Sbjct: 447  EGDSAKSLAMSGLQVVGRDRFGVFPLRGKLLNVRDCGMKQILDNEEIQNIIKILGLYMGR 506

Query: 131  EYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLK-VPSFMVEFTTPIIRAF 189
            +Y ++K+LRYG +MIMADQDHDGSHIKGL+INFIH+FWPSL+K  P+F+ EF TPII+A 
Sbjct: 507  QYDDLKTLRYGSIMIMADQDHDGSHIKGLIINFIHNFWPSLIKKFPTFVKEFVTPIIKAT 566

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNA-TGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N   L F+++ EYE W +  G N    ++IKYYKGLGTST  E ++YF+ + KH+ +F
Sbjct: 567  SHNEC-LQFFTIAEYEKWAQLKGTNELKSYRIKYYKGLGTSTALEAKQYFQSIKKHQINF 625

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
             ++DD D   I +AFSK KA+DRK W+  F P  Y DH  +++ Y +FV++ELI FS AD
Sbjct: 626  YYKDDKDEDKILLAFSKTKADDRKNWLSQFNPNIYVDHSKNKLCYAEFVDQELIHFSIAD 685

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSV+DGLKPGQRKILF  FK+KL  EIKV Q  GY++EH+AYHHGE SL  TII 
Sbjct: 686  NMRSIPSVMDGLKPGQRKILFACFKRKLKAEIKVAQLSGYIAEHTAYHHGEISLQMTIIN 745

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            MAQDFVGSNN+NLL+P GQFGTR +GGK+ AS RYIYT L P  R LF+ENDD LL+Y  
Sbjct: 746  MAQDFVGSNNLNLLQPIGQFGTRMMGGKESASPRYIYTNLTPFARSLFNENDDPLLKYQI 805

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            E+G  IEP +Y+P++PLVL+NG+EGIGTGWS+YIP ++P  II N++R L  +  + M P
Sbjct: 806  EEGMGIEPEFYVPVLPLVLINGAEGIGTGWSTYIPCFSPIHIIHNIKRHLEGKPFLRMQP 865

Query: 489  WYRGFKGIIE-KSAKEGG--YIVNGTVEEIDEQS-FRITELPIRKWTQDYKQFLESITDG 544
            WY+GF G IE K   E G  YI  G  +   E++   ITELP++KWT++YK FLE +   
Sbjct: 866  WYKGFTGQIEPKQNDESGLSYIDKGKFKVDKERNKLIITELPLQKWTREYKNFLEELAQ- 924

Query: 545  SPNVKDPLIEDFRQNGDDAMVDIEIRMKLEK--IAMIMQEGLLKKFKLTTTISTSNMHLF 602
                KD +I D ++   D  V  E++    K  I  +  + + KKFKLT+ ++ +N+ LF
Sbjct: 925  ----KDEII-DIKEFHQDNTVHFEVKFNRSKLDIGTLDDDQIEKKFKLTSNLNCTNLVLF 979

Query: 603  DAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEI 662
            D   KIKKYEN  QILEEFF  RL+ Y++RK+ +L+        L NK RF+  ++ G +
Sbjct: 980  DRNCKIKKYENECQILEEFFNYRLNLYKKRKESMLKIITEQYEKLSNKYRFVASIIDGSL 1039

Query: 663  VVSNRKKADLLMELQQKGF-------------------TPMPKKGKSAEPQVAGAXXXXX 703
             +  +KK D++  L++KGF                    P  K+GK A+           
Sbjct: 1040 EIYKKKKEDVVKLLKEKGFKTYQEIHGHQKQNLQQVENQPQEKQGKDAKKNFQ------- 1092

Query: 704  XXXXXXXXXXXXXXXXXXKRGDYEYLLSMSI 734
                              KR DY YLL+M I
Sbjct: 1093 ----------------LDKRQDYNYLLNMKI 1107


>B8NXR4_ASPFN (tr|B8NXR4) DNA topoisomerase 2 OS=Aspergillus flavus (strain ATCC
            200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
            GN=AFLA_008840 PE=3 SV=1
          Length = 1717

 Score =  716 bits (1848), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 373/750 (49%), Positives = 498/750 (66%), Gaps = 38/750 (5%)

Query: 3    FYTYMLQMFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNS 62
            FY  +L+      + ++  +L +A  K  + LKKTDG +  R+    KL DAN AG ++ 
Sbjct: 490  FYKKILK------TDVMSNILHFAQQKADQMLKKTDGGRRARMNN-PKLTDANKAGTKDG 542

Query: 63   DKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKK 122
              CTLILTEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+A+ +QI  N EIQNIK 
Sbjct: 543  HHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDATFEQISKNAEIQNIKN 602

Query: 123  ILGLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFT 182
             LGLQ  KEY++ + LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLL++P F++EF 
Sbjct: 603  FLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLRIPEFLIEFI 662

Query: 183  TPIIRAFHS---NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYF 238
            TPII+ +     N TK  SF++MPEYE+W+E    +  GW+ KYYKGLGTST ++ + YF
Sbjct: 663  TPIIKVWKGDPKNPTKQRSFFTMPEYEAWKEE-HKHERGWEHKYYKGLGTSTTEDAQVYF 721

Query: 239  RDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVN 298
            RDL +H K+F    D +   IE+AFSKKKA++RK W+R F+PG + DH  S+I+Y DF+N
Sbjct: 722  RDLDRHLKEFHTMQDNEVGLIELAFSKKKADERKEWLRQFKPGTFLDHSVSKISYTDFIN 781

Query: 299  KELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHG 358
            KELILFS AD  RSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G+VS  +AY HG
Sbjct: 782  KELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGMTAYQHG 841

Query: 359  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHE 418
            + SL  TI+G+AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +FH 
Sbjct: 842  DISLQQTIVGLAQSFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARRVFHA 901

Query: 419  NDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLL 478
            +DD LL Y  +DG  IEP  Y+P++P++LVNG++GIGTGWSS IPNYNP DI+ N++RL+
Sbjct: 902  HDDPLLTYNEDDGEKIEPEIYVPVVPMILVNGADGIGTGWSSSIPNYNPEDIVDNLKRLM 961

Query: 479  NDETMVPMDPWYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQ 536
            + E   PM PW+RGF G +      GG  +  +G ++E  E+   ITELPIR WTQD+K 
Sbjct: 962  DGEETRPMQPWFRGFTGEV---TDVGGDRFKFSGIIKETGEKEVEITELPIRTWTQDFKD 1018

Query: 537  FLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAM--IMQEGLLKKFKLTTT 593
             LE I       K P  I+D++        D     KL++  M   + EGL +KFKL+ T
Sbjct: 1019 KLEDIIKAE---KTPSFIKDYK--------DYNTHTKLDEKNMKSALSEGLEEKFKLSKT 1067

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++T+N+  FD EG+I KY   + IL+EF+  RL +YE+RKQY L   ++ L  L N+ RF
Sbjct: 1068 VATTNLVAFDPEGRITKYATVDDILKEFYTYRLKFYEKRKQYQLSQLQKELDKLSNQARF 1127

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXX 713
            +  ++ G++VVS +KK  L+ EL+ KG+   P   K AE   AG                
Sbjct: 1128 VQEIIDGKLVVSKKKKNVLVQELKDKGYKAFP---KVAEAVKAGEEERVVEEDDDESDSQ 1184

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        Y+YLL M+I +LT E V+
Sbjct: 1185 DTEVLSSA----YDYLLGMAIWSLTQERVE 1210


>G3B4R2_CANTC (tr|G3B4R2) DNA topoisomerase 2 OS=Candida tenuis (strain ATCC 10573
            / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL
            Y-1498 / VKM Y-70) GN=CANTEDRAFT_104632 PE=3 SV=1
          Length = 1429

 Score =  716 bits (1847), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 359/684 (52%), Positives = 489/684 (71%), Gaps = 13/684 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + I+D + S A+  + K L+K DG+K  R++G VKL DAN AG +   KCTLILTEG
Sbjct: 436  ILKTSIVDKIKSIANANEDKALQKADGSKKSRVKGQVKLVDANKAGTKEGHKCTLILTEG 495

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSA +LA+AGL+V+GRD+YG FPLRGKLLNVREAS  Q+  N EI  +K+I+GLQ  K+Y
Sbjct: 496  DSALSLAVAGLTVIGRDYYGCFPLRGKLLNVREASTDQVSKNVEINALKQIIGLQHKKKY 555

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF- 189
            +  NV  LRYGH+MIM DQD DGSHIKGL+INF+ S +P LL++P F++EF TPI++   
Sbjct: 556  TPENVSQLRYGHIMIMTDQDQDGSHIKGLIINFLESSFPGLLEIPGFLLEFITPIVKVTV 615

Query: 190  ---HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
                S+   LSFY+MPE+E+WRE  G     WK KYYKGLGTST  E REYF  L KH K
Sbjct: 616  SQRGSSKKVLSFYTMPEFENWRETEGTRCR-WKQKYYKGLGTSTDVEAREYFAALDKHLK 674

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
             F      D   I++AFSKKKA++RK W++ F+PG + D     I   DF+NKELILFS 
Sbjct: 675  QFHAIQGEDPDLIDLAFSKKKADERKNWLQEFQPGTHLDPELKIIPISDFINKELILFSM 734

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
            AD  RSIPSV+DG KPGQRK+LF  FK+ L  EIKV Q  GYVSEH+ YHHGEQSL  TI
Sbjct: 735  ADNVRSIPSVLDGFKPGQRKVLFGCFKRNLKSEIKVAQLAGYVSEHTGYHHGEQSLIQTI 794

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            IG+AQ+F+GSNN+NLLKPNG FGTR  GGKD +++RYI+TE+N ITR +F+  D+ LL Y
Sbjct: 795  IGLAQNFIGSNNLNLLKPNGAFGTRAAGGKDFSAARYIFTEINEITRKIFNPLDNGLLTY 854

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
            + ED +++EP WY+PIIP++LVNG+EGIGTGWS+ IP YNP DI+AN+R+L+N+E +  M
Sbjct: 855  VQEDEQTVEPEWYLPIIPMILVNGAEGIGTGWSTNIPCYNPEDIVANIRKLMNNEELEEM 914

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
             PWYRG++G +E  +KE  + V+G +E+ID+Q+  ITE+P++ WT + K+FL S   G+ 
Sbjct: 915  FPWYRGWEGDLEIISKE-KFKVSGRIEQIDDQTLEITEIPVKTWTNNVKEFLLSGL-GND 972

Query: 547  NVKDPLIEDF-RQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
             VK P I+D   Q+G +  +   +++  E++A   Q GLL +FKL ++I+ +NM  FD  
Sbjct: 973  KVK-PWIKDMEEQHGMN--IRFVVKLSQEEMAKSHQVGLLDRFKLISSINLTNMVAFDPR 1029

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            GKIKKYE+  +IL++F+ +RL++Y++RK ++++  +  L  L  + RFI  ++   I VS
Sbjct: 1030 GKIKKYESSLEILKDFYYVRLEFYQKRKDFMIDELKNQLDKLTEQARFIKLIIEKVISVS 1089

Query: 666  NRKKADLLMELQQKGFTPMPKKGK 689
            N+K+ +L+  LQ+  F    K+ K
Sbjct: 1090 NKKRKELIEILQKHKFKRFNKQNK 1113


>Q8X1U3_PENCH (tr|Q8X1U3) DNA topoisomerase 2 (Fragment) OS=Penicillium chrysogenum
            GN=TOP 2 PE=3 SV=1
          Length = 1423

 Score =  716 bits (1847), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 369/740 (49%), Positives = 494/740 (66%), Gaps = 25/740 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K   DLKK D  +  R+    KL DAN AG R    CTLILTEG
Sbjct: 383  VLKTEVMSNILHFAEQKADPDLKKGDTGRRTRMNN-PKLVDANKAGTREGRHCTLILTEG 441

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            +SAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQ+IK  +GLQ  KEY
Sbjct: 442  ESAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNVEIQSIKNFIGLQHKKEY 501

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPII+ +   
Sbjct: 502  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGD 561

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPE++ WRE    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 562  PKNPTKQKSFFTMPEHDEWRE-AHQHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 620

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG + DH  ++I Y DF+NKELILFS AD
Sbjct: 621  HTMQDGEAGLIELAFSKKKADERKEWLRQFKPGTFLDHSGAKITYTDFINKELILFSMAD 680

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L   F++ L K++KV +  G+VS  +AYHHG+ SL  TI+G
Sbjct: 681  NQRSIPSVVDGLKPGQRKVLHTCFRRNLKKDMKVVELAGHVSGMTAYHHGDVSLQQTIVG 740

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH  D+ LL Y  
Sbjct: 741  LAQTFVGSNNINCLEPSGNFGSRLQGGGDCASARYIYTRLSPFARKVFHSADEPLLTYNE 800

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  ++P++P++L+NG++GIGTGWSS IPNYNP +++ N++RL+  E   PM P
Sbjct: 801  DDGKKIEPEVFMPVVPMILINGADGIGTGWSSSIPNYNPEEVVNNLKRLMAGEPTEPMQP 860

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  +  +G + E  E+   ITELPIR WTQD+K  LE I     
Sbjct: 861  WFRGFTGEV---VAVGGDRFKFSGIIRECGEKEVEITELPIRTWTQDFKDKLEEIIKAE- 916

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D+R       V   I++  + + + + EGL +KFKLT TI+T+N+  FD E
Sbjct: 917  --KVPSFIKDYRDYNTHTKVHFIIQLDEKHMKVALTEGLEEKFKLTKTIATTNLVAFDPE 974

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EFF +RL YYERRKQ+ L + +R L  L N+ RF+  ++ G++V+S
Sbjct: 975  GRITKYATVDDILKEFFVVRLKYYERRKQFQLADLQRDLEKLSNQARFVQMIIDGKLVIS 1034

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKR-- 723
             +K+ DL+ EL+ KGF P+ K        VA A                       ++  
Sbjct: 1035 KKKRPDLIAELKDKGFKPISK--------VAEAPKMGEDEPVVEEEGEEESDDNDTQKLS 1086

Query: 724  GDYEYLLSMSIGTLTLESVQ 743
              ++YLLSM + +LT E V+
Sbjct: 1087 SSFDYLLSMPMWSLTQERVE 1106


>H3A5L5_LATCH (tr|H3A5L5) DNA topoisomerase 2 OS=Latimeria chalumnae PE=3 SV=1
          Length = 1401

 Score =  715 bits (1845), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/750 (50%), Positives = 506/750 (67%), Gaps = 32/750 (4%)

Query: 12  AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
           A AN GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S  CTLILT
Sbjct: 204 AAANCGIVESILNWVRFKAQIQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSLDCTLILT 263

Query: 71  EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
           EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI +I KI+GLQ  K
Sbjct: 264 EGDSAKSLAVSGLGVIGRDRYGVFPLRGKMLNVREASHKQIMENAEINSIIKIVGLQYKK 323

Query: 131 EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
            Y +   +KSLRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK  +F+ EF TPI++
Sbjct: 324 SYEDPDSLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HNFLEEFITPIVK 382

Query: 188 AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
           A   N  +L+FYS+PE++ W++    + + W+IKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 383 A-TKNKQELAFYSIPEFDEWKKQTETHKS-WRIKYYKGLGTSTAKEAKEYFADMERHRIL 440

Query: 248 FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
           F +    D +AI +AFSKKK +DRK W+ NF            P  Y    A++ + Y D
Sbjct: 441 FRYGGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQYLYGTATKHLTYND 500

Query: 296 FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
           F+NKELILFS +D +RSIPS+VDG KPGQRK+LF   K+   +E+KV Q  G V+E SAY
Sbjct: 501 FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCCKRNDKREVKVAQLAGSVAEMSAY 560

Query: 356 HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
           HHGEQ+L  TI+ +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI+T L+P+TR L
Sbjct: 561 HHGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLTRLL 620

Query: 416 FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
           F   DD+LL++L +D + +EP WYIPIIP+VLVNG+EGIGTGW+  IPNY+PR+I+ NVR
Sbjct: 621 FPPVDDQLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVVNVR 680

Query: 476 RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
           R+L+ +  +PM P Y+ +KGII +   +  Y+V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 681 RMLDGQDPLPMLPSYKSYKGIIHELG-QNQYVVSGEIFVLDRNTVEITELPLRTWTQVYK 739

Query: 536 -QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
            Q LE + +G+      LI D+++   D  V   ++M  EK+A     GL K FKL T++
Sbjct: 740 EQVLEPMLNGTEKTP-ALINDYKEYHTDTTVKFVVKMTEEKLAQAEAVGLHKVFKLQTSL 798

Query: 595 STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
           + ++M LFD  G +KKYE  ++IL+EFF LRL YY  RK++++  F      L+N+ RFI
Sbjct: 799 TCNSMVLFDHMGCMKKYETVQEILKEFFDLRLHYYNLRKEWLMGMFGAESAKLNNQARFI 858

Query: 655 LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXXX 713
           L  + G I + N+ K DL+  L Q+GF   P K  K A+ + A                 
Sbjct: 859 LEKIQGTITIENKSKRDLIHMLVQRGFESDPIKSWKEAQEKAAEDEDQDDDSSSDSGSTS 918

Query: 714 XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                      D+ Y+L+MS+ +LT E V+
Sbjct: 919 GP---------DFNYILNMSLWSLTKEKVE 939


>R1ENP0_EMIHU (tr|R1ENP0) Uncharacterized protein OS=Emiliania huxleyi CCMP1516
            GN=EMIHUDRAFT_458166 PE=4 SV=1
          Length = 1268

 Score =  715 bits (1845), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 380/812 (46%), Positives = 497/812 (61%), Gaps = 97/812 (11%)

Query: 15   NSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
            N G+L+++LS+A  KQSKDLKKTDGTK  RL GI KL+DAN+AGGRN  KCTLI+TEGDS
Sbjct: 373  NCGVLESILSFAQSKQSKDLKKTDGTKKSRLTGIPKLDDANEAGGRNGSKCTLIITEGDS 432

Query: 75   AKALAMAGLSVVGR---------------------DHYGVFPLRGKLLNVREASNKQIMD 113
            AKALA+AGLS+VGR                     DHYGVFPLRGKLLNVR+A++  IM 
Sbjct: 433  AKALAVAGLSIVGRATACKGCARHPHTGCRTVDRRDHYGVFPLRGKLLNVRDAAHSTIMA 492

Query: 114  NEEIQNIKKILGLQQNKEY---SNVKSLRYGH-------------------------LMI 145
            N+EI  +K+ILGLQQ K Y   +++KSLRYG                          LMI
Sbjct: 493  NKEISELKQILGLQQGKSYDDEASLKSLRYGERRGGDLAAPHPFRAPLTPCPPCAGKLMI 552

Query: 146  MADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK-LSFYSMPEY 204
            M DQDHDGSHIKGL+INF+H +WP+LL+  +    F TPI++A  S G + ++F+++ EY
Sbjct: 553  MTDQDHDGSHIKGLVINFLHCYWPALLQKRAAPARFVTPIVKA--SKGRQAIAFFTLKEY 610

Query: 205  ESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEMAFS 264
            E+WRE  G  A+GW+IKYYKGLGTS+  E + YF DL  H   F W  D D   I  AFS
Sbjct: 611  ENWREEQGAAASGWQIKYYKGLGTSSAAEAKAYFSDLDLHELSFKWTGDADREGIVRAFS 670

Query: 265  KKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLKPGQ 324
            K  A+ RK W+R ++   Y DH  S + Y DFV++ELI FS AD  RSIPS         
Sbjct: 671  KSMADARKEWLRGYDADAYVDHSQSHLTYHDFVDRELIHFSNADNMRSIPSF-------- 722

Query: 325  RKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLKP 384
                          E+KV Q  GY     AYHHGE SL  TI+GMAQ FVGSNNI LL  
Sbjct: 723  --------------EVKVAQLAGY-----AYHHGEASLGGTIVGMAQTFVGSNNIALLHG 763

Query: 385  NGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIP 444
             GQFGTR +GGKD AS RYI+ +L  +TR +FH +DD LLEYL +DG+ IEP +Y+PI+P
Sbjct: 764  AGQFGTRLMGGKDAASPRYIFCKLPQLTRLIFHPHDDALLEYLEDDGQRIEPRYYMPILP 823

Query: 445  LVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSAKEG 504
            +VLVNG++GIGTGWSS +PN+NPRDI+AN+RRL+  E   PM PWYRGF G +  + ++G
Sbjct: 824  MVLVNGADGIGTGWSSSVPNFNPRDIVANLRRLMAGEEPEPMTPWYRGFAGTVTPADQKG 883

Query: 505  GYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ-----FLESITDGSPNVKD--PLIEDFR 557
             Y   G++ + DE++ RI+ELP+RKWTQDYK+      +    DG+    +    + + R
Sbjct: 884  SYSTYGSIAKADERTLRISELPVRKWTQDYKETVLEPMMSDRADGAAKSAELAGALAELR 943

Query: 558  QNGDDAMVDIEIRMKLEKIAMIMQE-GLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQ 616
            +N  D  V   ++   +  A    + GL K  KL+++ISTSNM LFDA+G+I+KYE  E 
Sbjct: 944  ENHTDTTVSFTLKFASDAAAAAANKVGLHKALKLSSSISTSNMTLFDAQGRIQKYEAVEA 1003

Query: 617  ILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMEL 676
            +L +F+ LRL +YE+RK ++ +        LDN++RF+L V+SGE+ ++NRKKADL+ EL
Sbjct: 1004 VLRDFYALRLSFYEKRKLHLQDKLTGEWSKLDNRMRFVLAVISGELKIANRKKADLVAEL 1063

Query: 677  QQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGT 736
             QKG+ P        EP  A                          RG Y+YLLSM + +
Sbjct: 1064 AQKGYAPF-------EP--APKRAAAGDDGEEEAAGEAEGGASASARG-YDYLLSMPLWS 1113

Query: 737  LTLESVQXXXXXXXXXXXXXXXXXATPSKSMW 768
            LT E V+                 AT  + +W
Sbjct: 1114 LTRERVEQLRGECTAKEAELQTLLATSPRQLW 1145


>J9K4Y7_ACYPI (tr|J9K4Y7) DNA topoisomerase 2 OS=Acyrthosiphon pisum PE=3 SV=1
          Length = 1535

 Score =  714 bits (1843), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/696 (52%), Positives = 480/696 (68%), Gaps = 27/696 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             V+  GI++ +LSWA FK    L+K  G K  +L+G+ KLEDANDAG RNS  CTLILTE
Sbjct: 392  GVSKCGIVEAVLSWAKFKAQTQLQKQSGKKQSKLKGVPKLEDANDAGTRNSIDCTLILTE 451

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK+LA++GL VVGRD YGVFPLRGKLLNVREAS+KQIMDN EI NI KI+GLQ  K+
Sbjct: 452  GDSAKSLAVSGLGVVGRDKYGVFPLRGKLLNVREASHKQIMDNAEISNIVKIVGLQYKKK 511

Query: 132  YS---NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA 188
            Y    ++KSLRYG LMIM DQD DGSHIKGL+INFIH  WP+LLK+P F+ EF TPI++A
Sbjct: 512  YETMEDLKSLRYGRLMIMTDQDQDGSHIKGLIINFIHHNWPTLLKLP-FLEEFITPIVKA 570

Query: 189  FHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                  + SFYS+PE+E W++    N   +KIKYYKGLGTST +E +EYF+++ +HR  F
Sbjct: 571  TKGKD-ETSFYSLPEFEEWKD-ATRNWNKYKIKYYKGLGTSTSKEAKEYFQNMKRHRILF 628

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNF--------EPGNYRDHVASR----INYKDF 296
             +ED  D   IEMAFSKK  + RK W+ N+        E G   +++  +    + YKDF
Sbjct: 629  KYEDAGDDEHIEMAFSKKMVDSRKEWLTNWMVESKRRKEAGLAEEYLYEKNTRTVTYKDF 688

Query: 297  VNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYH 356
            VNKEL+LFS  D +RSI SVVDGLKPG RK+LF   K+   +EIKV Q  G V+EHSAYH
Sbjct: 689  VNKELVLFSNMDNERSIASVVDGLKPGSRKVLFTCIKRNDKREIKVAQLAGSVAEHSAYH 748

Query: 357  HGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLF 416
            HGE SL STI+ +AQ++VGSNNINLL+P GQFGTR  GGKD AS RYI+T L+P+TR +F
Sbjct: 749  HGEVSLMSTIVNLAQNYVGSNNINLLQPIGQFGTRLQGGKDAASPRYIFTMLSPLTRLIF 808

Query: 417  HENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRR 476
            H +DD LL YL +D + IEP WY+PIIP+VLVNG+EGIGTGW + IPN+NPR++I+N++R
Sbjct: 809  HPHDDPLLTYLRDDNQKIEPVWYMPIIPMVLVNGAEGIGTGWMTKIPNHNPREVISNIKR 868

Query: 477  LLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ 536
            +L  E  +PM PWY+ F G IEK + E  +I +G +  I      ITELP+  WTQ+YK+
Sbjct: 869  MLRGEDPLPMKPWYKNFTGHIEKLS-EQKFISSGELGVIGHNRVEITELPVGVWTQNYKE 927

Query: 537  -FLESI---TDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTT 592
              LE +   T+ SP V    I D+++   D  +   I M  EK+     EG+ K FKL  
Sbjct: 928  SVLEPMLTDTEKSPAV----ITDYKEYNTDTTIKFVITMNPEKLQKAENEGIHKFFKLHA 983

Query: 593  TISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVR 652
            +I  ++M  FD +  +KKYE  +QIL EF+ +RLD+Y +RK Y+          L N+ R
Sbjct: 984  SIGLTSMCAFDKDCVLKKYEATQQILREFYAVRLDFYGKRKAYLEGMLGAEAAKLTNQAR 1043

Query: 653  FILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG 688
            FI+    G++ + NRKK++++ EL ++G+   P K 
Sbjct: 1044 FIVEKCDGDLRIENRKKSEMVKELVRRGYNSDPVKA 1079


>Q8X1U2_PENCI (tr|Q8X1U2) DNA topoisomerase 2 (Fragment) OS=Penicillium citrinum
            GN=TOP 2 PE=3 SV=1
          Length = 1100

 Score =  714 bits (1842), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/735 (50%), Positives = 488/735 (66%), Gaps = 23/735 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +++ +L +A  K  + LKK+DG +  R+    KL +AN AG ++   CTLILTEG
Sbjct: 379  ILKTDVMNNILHFAAQKADQILKKSDGGRRTRMNN-PKLVEANKAGTKDGHHCTLILTEG 437

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 438  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNAEIQNIKNFIGLQHKKEY 497

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            +  K LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPII+ +   
Sbjct: 498  TETKGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGD 557

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE W E       GW  KYYKGLGTS+  + + YFRDL +H K+F
Sbjct: 558  PKNPTKQRSFFTMPEYEEWLE-AHKGERGWDHKYYKGLGTSSTTDAQVYFRDLDRHLKEF 616

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   IE+AFSKKKA++RK W+R F+PG Y DH  S+I+Y DF+NKELILFS AD
Sbjct: 617  HTMKDHEAELIELAFSKKKADERKEWLRQFKPGTYLDHSVSKISYTDFINKELILFSMAD 676

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  F++ L K++KV +  G VS  +AY HGE SL  TI+G
Sbjct: 677  NQRSIPSVVDGLKPGQRKVLYACFRRNLKKDMKVVELAGLVSGMTAYQHGETSLQQTIVG 736

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH  D+ LL Y  
Sbjct: 737  LAQTFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPFARKIFHTADEPLLTYNE 796

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++P+VL+NG++GIGTGWSS IPNYNP D++ N++RL+  E + PM P
Sbjct: 797  DDGKKIEPETYMPVVPMVLINGADGIGTGWSSSIPNYNPEDVVNNLKRLMKGEPIEPMQP 856

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  +  +G ++E  ++   ITELPIR WTQD+K  LE I     
Sbjct: 857  WFRGFTGEV---VNMGGDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAE- 912

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D++       V   I++  + +   + EGL +KFKLT +I+TSN+  FD E
Sbjct: 913  --KVPSFIKDYKDYNTHDKVHFVIQLDEKNMKAALSEGLEEKFKLTKSIATSNLVAFDPE 970

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EFF +RL YYERRKQ+ L   ++ L  L N+ RF+  ++ G++V+S
Sbjct: 971  GRITKYATVDDILKEFFTVRLKYYERRKQHQLSELQKELEKLSNQARFVQMIIDGKLVIS 1030

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
             +KK+ L+ EL++KGF    K        VA A                           
Sbjct: 1031 KKKKSVLVNELREKGFKAFTK--------VADAAKLGEDEAVVEEGEEDDDADVEVLSSS 1082

Query: 726  YEYLLSMSIGTLTLE 740
            Y+YLL M++ +LT E
Sbjct: 1083 YDYLLGMALWSLTHE 1097


>Q76C40_9EURO (tr|Q76C40) DNA topoisomerase 2 (Fragment) OS=Arthroderma fulvum
            GN=top2 PE=3 SV=1
          Length = 1086

 Score =  713 bits (1841), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 350/679 (51%), Positives = 473/679 (69%), Gaps = 12/679 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++D +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLILTEG
Sbjct: 372  VMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLILTEG 430

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 431  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEY 490

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
            ++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +  +
Sbjct: 491  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGD 550

Query: 193  ----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                    SF+++PEYE W+E   ++   W+ KYYKGLGTS+ ++ + YF+DL +H K F
Sbjct: 551  PKNPTHSKSFFTLPEYEEWKEAHAHDKK-WQKKYYKGLGTSSTEDAQVYFQDLDRHLKQF 609

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS AD
Sbjct: 610  HTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSMDQITYTDFINKELILFSMAD 669

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
              RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +TI+G
Sbjct: 670  NIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVG 729

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL    
Sbjct: 730  LAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNV 789

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  Y+P++PL+L+NG++GIGTGWS+ IPNYNP D++ N++RL+  + +VPM P
Sbjct: 790  DDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEDVVDNLKRLMAGDELVPMKP 849

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGFKG +  S     Y  +G +++  +    I+ELPIR WTQD+K  LE I       
Sbjct: 850  WFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEISELPIRTWTQDFKDKLEEIIKAE--- 904

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M+ + +   ++EGL +KFKL   I+TSNM  FD EG+
Sbjct: 905  KVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKAVEEGLEEKFKLVKQIATSNMVAFDPEGR 964

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V+S +
Sbjct: 965  ITRYETPEDILRAFYAVRIKLYEKRKQHLLSELQTQLDKLSNQARFVQMIIDGKLVISKK 1024

Query: 668  KKADLLMELQQKGFTPMPK 686
            KKA L+ ELQ+KGF P PK
Sbjct: 1025 KKALLIQELQEKGFKPFPK 1043


>B6HPI3_PENCW (tr|B6HPI3) DNA topoisomerase 2 OS=Penicillium chrysogenum (strain
            ATCC 28089 / DSM 1075 / Wisconsin 54-1255) GN=top2 PE=3
            SV=1
          Length = 1725

 Score =  713 bits (1840), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 369/740 (49%), Positives = 493/740 (66%), Gaps = 25/740 (3%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKK D  +  R+    KL DAN AG R    CTLILTEG
Sbjct: 507  VLKTEVMSNILHFAEQKADQILKKGDTGRRTRMNN-PKLVDANKAGTREGHHCTLILTEG 565

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            +SAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQ+IK  +GLQ  KEY
Sbjct: 566  ESAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNVEIQSIKNFIGLQHKKEY 625

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ K LRYGHLMIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPII+ +   
Sbjct: 626  TDTKGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGD 685

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPE++ WRE    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 686  PKNPTKQKSFFTMPEHDEWRE-AHQHERGWEHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 744

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R F+PG + DH  ++I Y DF+NKELILFS AD
Sbjct: 745  HTMQDGEAGLIELAFSKKKADERKEWLRQFKPGTFLDHSVAKITYTDFINKELILFSMAD 804

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L   F++ L K++KV +  G+VS  +AYHHG+ SL  TI+G
Sbjct: 805  NQRSIPSVVDGLKPGQRKVLHTCFRRNLKKDMKVVELAGHVSGMTAYHHGDVSLQQTIVG 864

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH  D+ LL Y  
Sbjct: 865  LAQTFVGSNNINCLEPSGNFGSRLQGGGDCASARYIYTRLSPFARKVFHSADEPLLTYNE 924

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  ++P++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+  E   PM P
Sbjct: 925  DDGKKIEPEVFMPVVPMILINGADGIGTGWSSSIPNYNPEDVVNNLKRLMAGEPTEPMQP 984

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  +  +G + E  E+   ITELPIR WTQD+K  LE I     
Sbjct: 985  WFRGFTGEV---VAVGGDRFKFSGIIRECGEKEVEITELPIRTWTQDFKDKLEEIIKAE- 1040

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D+R       V   I++  + + + + EGL +KFKLT TI+T+N+  FD E
Sbjct: 1041 --KVPSFIKDYRDYNTHTKVHFIIQLDEKHMKVALTEGLEEKFKLTKTIATTNLVAFDPE 1098

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EFF +RL YYERRKQ+ L + +R L  L N+ RF+  ++ G++V+S
Sbjct: 1099 GRITKYATVDDILKEFFVVRLKYYERRKQFQLADLQRDLEKLSNQARFVQMIIDGKLVIS 1158

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKR-- 723
             +KK  L+ EL+ KGF P+ K        VA A                       ++  
Sbjct: 1159 KKKKPVLIAELKDKGFKPISK--------VAEAPKMGEDEPVVEEEGEEESDDNDTQKLS 1210

Query: 724  GDYEYLLSMSIGTLTLESVQ 743
              ++YLLSM + +LT E V+
Sbjct: 1211 SSFDYLLSMPMWSLTQERVE 1230


>H0YZ82_TAEGU (tr|H0YZ82) DNA topoisomerase 2 OS=Taeniopygia guttata GN=TOP2B PE=3
            SV=1
          Length = 1622

 Score =  712 bits (1838), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/750 (50%), Positives = 502/750 (66%), Gaps = 29/750 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S  CTLILT
Sbjct: 422  AASNCGIIESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSLDCTLILT 481

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 482  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 541

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +KSLRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 542  SYEDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 600

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++ N+   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 601  A-SKNKQELSFYSIPEFDEWKKHMENHK-AWKIKYYKGLGTSTAKEAKEYFADMERHRIL 658

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 659  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 718

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDGLKPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 719  FINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 778

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI+T L+P+ R L
Sbjct: 779  HHGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLL 838

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VLVNG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 839  FPSVDDNLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVR 898

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y+V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 899  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYVVSGEIFVVDRNTVEITELPVRTWTQVYK 957

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL T+
Sbjct: 958  EQVLEPMLNGTE--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTS 1015

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1016 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLHYYSLRKEWLVGMLGAESTKLNNQARF 1075

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXX 713
            IL  + G+I + NR K DL+  L Q+G+   P K      + A                 
Sbjct: 1076 ILEKIQGKITIENRSKRDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNANDDASSAS 1135

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                       D+ Y+L+MS+ +LT E V+
Sbjct: 1136 GPASGP-----DFNYILNMSLWSLTKEKVE 1160


>H3A5L4_LATCH (tr|H3A5L4) DNA topoisomerase 2 (Fragment) OS=Latimeria chalumnae
            PE=3 SV=1
          Length = 1615

 Score =  712 bits (1838), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 377/750 (50%), Positives = 507/750 (67%), Gaps = 34/750 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             AN GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S  CTLILTE
Sbjct: 413  AANCGIVESILNWVRFKAQIQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTE 472

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI +I KI+GLQ  K 
Sbjct: 473  GDSAKSLAVSGLGVIGRDRYGVFPLRGKMLNVREASHKQIMENAEINSIIKIVGLQYKKS 532

Query: 132  YSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA 188
            Y +   +KSLRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK  +F+ EF TPI++A
Sbjct: 533  YEDPDSLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HNFLEEFITPIVKA 591

Query: 189  FHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
               N  +L+FYS+PE++ W++    + + W+IKYYKGLGTST +E +EYF D+ +HR  F
Sbjct: 592  -TKNKQELAFYSIPEFDEWKKQTETHKS-WRIKYYKGLGTSTAKEAKEYFADMERHRILF 649

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKDF 296
             +    D +AI +AFSKKK +DRK W+ NF            P  Y    A++ + Y DF
Sbjct: 650  RYGGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQYLYGTATKHLTYNDF 709

Query: 297  VNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYH 356
            +NKELILFS +D +RSIPS+VDG KPGQRK+LF   K+   +E+KV Q  G V+E SAYH
Sbjct: 710  INKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCCKRNDKREVKVAQLAGSVAEMSAYH 769

Query: 357  HGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLF 416
            HGEQ+L  TI+ +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI+T L+P+TR LF
Sbjct: 770  HGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLTRLLF 829

Query: 417  HENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRR 476
               DD+LL++L +D + +EP WYIPIIP+VLVNG+EGIGTGW+  IPNY+PR+I+ NVRR
Sbjct: 830  PPVDDQLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVVNVRR 889

Query: 477  LLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK- 535
            +L+ +  +PM P Y+ +KGII +   +  Y+V+G +  +D  +  ITELP+R WTQ YK 
Sbjct: 890  MLDGQDPLPMLPSYKSYKGIIHELG-QNQYVVSGEIFVLDRNTVEITELPLRTWTQVYKE 948

Query: 536  QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
            Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL T++
Sbjct: 949  QVLEPMLNGTE--KTPALINDYKEYHTDTTVKFVVKMTEEKLAQAEAVGLHKVFKLQTSL 1006

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            + ++M LFD  G +KKYE  ++IL+EFF LRL YY  RK++++  F      L+N+ RFI
Sbjct: 1007 TCNSMVLFDHMGCMKKYETVQEILKEFFDLRLHYYNLRKEWLMGMFGAESAKLNNQARFI 1066

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMP-KKGKSAEPQVAGAXXXXXXXXXXXXXXX 713
            L  + G I + N+ K DL+  L Q+GF   P K  K A+ + A                 
Sbjct: 1067 LEKIQGTITIENKSKRDLIHMLVQRGFESDPIKSWKEAQEKAAEDEDQDDDSSSDSGSTS 1126

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                       D+ Y+L+MS+ +LT E V+
Sbjct: 1127 GP---------DFNYILNMSLWSLTKEKVE 1147


>Q8X1U7_9EURO (tr|Q8X1U7) DNA topoisomerase 2 (Fragment) OS=Aspergillus candidus
            GN=TOP 2 PE=3 SV=1
          Length = 1096

 Score =  712 bits (1838), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 369/733 (50%), Positives = 495/733 (67%), Gaps = 18/733 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKKTDG K  R+    KL DAN AG ++   CTLILTEG
Sbjct: 377  VLKTEVMTNILHFAEKKADQLLKKTDGGKRSRMNN-PKLTDANKAGTKDGHHCTLILTEG 435

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  KEY
Sbjct: 436  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASIDQISKNAEIQNIKSFIGLQHKKEY 495

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            ++ + LRYGHLMIM DQDHDGSHIKGLLINF+   +PSLLK+P F++EF TPI++ +   
Sbjct: 496  TDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPEFLIEFITPIVKVWKGD 555

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPEYE W+E   N+   W+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 556  PKNPTKSKSFFTMPEYEQWKEEHKND-RAWQHKYYKGLGTSTTEDAQIYFRDLDRHLKEF 614

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D++   I++AFSKKKA++RK W+R ++PG + DH   +I Y DF+NKELILFS AD
Sbjct: 615  HTMQDHEAQLIDLAFSKKKADERKEWLRQYKPGTFLDHSTKQITYTDFINKELILFSMAD 674

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L+  FK+ + K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 675  NQRSIPSVVDGLKPGQRKVLYTCFKRNVKKDMKVVELAGHVSGMTAYQHGDTSLQQTIVG 734

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNN+N L+P+G FG+R  GG D AS+RYIYT L+P  R +F++ D+ LL Y  
Sbjct: 735  LAQTFVGSNNLNCLEPSGNFGSRLQGGADCASARYIYTRLSPFARRVFNQQDEPLLTYNE 794

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG  IEP  Y+P++PL+L+NG++GIGTGWSS IPNYNP DI+AN++R+++ E   PM P
Sbjct: 795  DDGEKIEPELYVPVVPLILINGADGIGTGWSSSIPNYNPEDIVANLKRMMDGEEPEPMQP 854

Query: 489  WYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNV 548
            W+RGF G +     +  Y  +G ++E++E+   ITELPIR WTQD+K  LE I       
Sbjct: 855  WFRGFHGDVTPQGPD-RYKFSGRIQELNEKEVEITELPIRTWTQDFKDKLEDIIKAE--- 910

Query: 549  KDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGK 607
            K P  I+D++       V   I+M  + +   ++EGL +KFKL+ TI+T+N+  FD EG+
Sbjct: 911  KTPSFIKDYKDYNTHTKVHFVIQMDEKHLKSAVEEGLEEKFKLSKTIATTNLVAFDPEGR 970

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            I KY     IL+EFF +RL YYERRKQ+ L   ++ L  L N+ RF+  ++ G++VVS +
Sbjct: 971  ITKYATVSDILKEFFAVRLKYYERRKQHQLSELQKDLDKLTNQARFVQMIIDGKLVVSKK 1030

Query: 668  KKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYE 727
            KK+ L+ EL++KGF   P   K AE   AG                            Y+
Sbjct: 1031 KKSILITELKEKGFKAFP---KVAEAVKAGETEQVVEEEGSEEEEAKTEVASNA----YD 1083

Query: 728  YLLSMSIGTLTLE 740
            YLL M+I +LT E
Sbjct: 1084 YLLGMAIWSLTHE 1096


>E1BZ19_CHICK (tr|E1BZ19) DNA topoisomerase 2 OS=Gallus gallus GN=TOP2B PE=2 SV=2
          Length = 1627

 Score =  711 bits (1836), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 377/759 (49%), Positives = 505/759 (66%), Gaps = 47/759 (6%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S  CTLILT
Sbjct: 427  AASNCGIIESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSLDCTLILT 486

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 487  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 546

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +KSLRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 547  SYEDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 605

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++ N+   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 606  A-SKNKQELSFYSIPEFDEWKKHMENHK-AWKIKYYKGLGTSTAKEAKEYFADMERHRIL 663

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 664  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 723

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDGLKPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 724  FINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 783

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI+T L+P+ R L
Sbjct: 784  HHGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLL 843

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VLVNG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 844  FPSVDDNLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVR 903

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ F+G I++   +  Y+V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 904  RMLDGLDPHPMLPNYKNFRGTIQELG-QNQYVVSGEIFVVDRNTVEITELPVRTWTQVYK 962

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL T+
Sbjct: 963  EQVLEPMLNGTE--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTS 1020

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1021 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLHYYSLRKEWLVGMLGAESTKLNNQARF 1080

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG---------KSAEPQVAGAXXXXXX 704
            IL  + G+I + NR K DL+  L Q+G+   P K          +  +PQ A        
Sbjct: 1081 ILEKIQGKITIENRSKRDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDPQNAN------- 1133

Query: 705  XXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                                D+ Y+L+MS+ +LT E V+
Sbjct: 1134 -------DDASSASGSTSGPDFNYILNMSLWSLTKEKVE 1165


>K9FXX9_PEND1 (tr|K9FXX9) DNA topoisomerase 2 OS=Penicillium digitatum (strain Pd1
            / CECT 20795) GN=PDIP_46230 PE=3 SV=1
          Length = 1758

 Score =  711 bits (1836), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 365/738 (49%), Positives = 488/738 (66%), Gaps = 18/738 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKK++  +  R+    KL DAN AG R    CTLILTEG
Sbjct: 505  VLKTEVMSNILHFAEQKADQILKKSETGRRTRMNN-PKLVDANKAGTREGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQ+IK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNVEIQSIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            +  K LRYGH+MIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPII+ +   
Sbjct: 624  TETKGLRYGHIMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGD 683

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPE++ WR+    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 684  PKNPTKQKSFFTMPEHDEWRQ-AHKHERGWQHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R ++PG Y DH  ++I Y DF+NKELILFS AD
Sbjct: 743  HTMQDGEAGLIELAFSKKKADERKEWLRQYKPGTYLDHSVAKITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L   F + L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 803  NQRSIPSVVDGLKPGQRKVLHTCFIRNLKKDMKVVELAGHVSGMTAYQHGDVSLQQTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH  D+ LL Y  
Sbjct: 863  LAQTFVGSNNINCLEPSGNFGSRLQGGGDCASARYIYTRLSPFARKIFHAADEPLLTYNE 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  +IP++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+  E   PM P
Sbjct: 923  DDGKKIEPEVFIPVVPMILINGADGIGTGWSSSIPNYNPEDVVNNLKRLMAGEPTEPMQP 982

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  Y  +G + E  E+   ITELP+R WTQD+K  LE I     
Sbjct: 983  WFRGFTGEV---VAVGGDRYKFSGIIRECGEKEVEITELPLRTWTQDFKDKLEEIIKAE- 1038

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D+R       V   I++  + +   + EGL +KFKLT +I+T+N+  FD E
Sbjct: 1039 --KVPSFIKDYRDYNTHTKVHFIIQLDEKHMKAALSEGLEEKFKLTKSIATTNLVAFDPE 1096

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EF+ +RL YYERRKQ+ L N +R L  L N+ RF+  ++ G++V+S
Sbjct: 1097 GRITKYATVDDILKEFYVVRLKYYERRKQFQLSNLQRELEKLSNQARFVQMIIDGKLVIS 1156

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
             +KK  L+ EL++KGF P+    K AE    G                            
Sbjct: 1157 KKKKPVLITELKEKGFKPI---AKVAEAAKMGEDEAVVEEGLEEGEDESDDPNAEVLSSS 1213

Query: 726  YEYLLSMSIGTLTLESVQ 743
            ++YLL M + +LT E V+
Sbjct: 1214 FDYLLGMPMWSLTQERVE 1231


>K9FFX4_PEND2 (tr|K9FFX4) DNA topoisomerase 2 OS=Penicillium digitatum (strain
            PHI26 / CECT 20796) GN=PDIG_75760 PE=3 SV=1
          Length = 1758

 Score =  711 bits (1836), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 365/738 (49%), Positives = 488/738 (66%), Gaps = 18/738 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  + ++  +L +A+ K  + LKK++  +  R+    KL DAN AG R    CTLILTEG
Sbjct: 505  VLKTEVMSNILHFAEQKADQILKKSETGRRTRMNN-PKLVDANKAGTREGHHCTLILTEG 563

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQ+IK  +GLQ  KEY
Sbjct: 564  DSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQISKNVEIQSIKNFIGLQHKKEY 623

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS- 191
            +  K LRYGH+MIM DQDHDGSHIKGLLINF+ + +PSLLK+P F++EF TPII+ +   
Sbjct: 624  TETKGLRYGHIMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIIKVWKGD 683

Query: 192  --NGTKL-SFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
              N TK  SF++MPE++ WR+    +  GW+ KYYKGLGTST ++ + YFRDL +H K+F
Sbjct: 684  PKNPTKQKSFFTMPEHDEWRQ-AHKHERGWQHKYYKGLGTSTTEDAQVYFRDLDRHLKEF 742

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRAD 308
                D +   IE+AFSKKKA++RK W+R ++PG Y DH  ++I Y DF+NKELILFS AD
Sbjct: 743  HTMQDGEAGLIELAFSKKKADERKEWLRQYKPGTYLDHSVAKITYTDFINKELILFSMAD 802

Query: 309  LQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIG 368
             QRSIPSVVDGLKPGQRK+L   F + L K++KV +  G+VS  +AY HG+ SL  TI+G
Sbjct: 803  NQRSIPSVVDGLKPGQRKVLHTCFIRNLKKDMKVVELAGHVSGMTAYQHGDVSLQQTIVG 862

Query: 369  MAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLN 428
            +AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R +FH  D+ LL Y  
Sbjct: 863  LAQTFVGSNNINCLEPSGNFGSRLQGGGDCASARYIYTRLSPFARKIFHAADEPLLTYNE 922

Query: 429  EDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDP 488
            +DG+ IEP  +IP++P++L+NG++GIGTGWSS IPNYNP D++ N++RL+  E   PM P
Sbjct: 923  DDGKKIEPEVFIPVVPMILINGADGIGTGWSSSIPNYNPEDVVNNLKRLMAGEPTEPMQP 982

Query: 489  WYRGFKGIIEKSAKEGG--YIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSP 546
            W+RGF G +      GG  Y  +G + E  E+   ITELP+R WTQD+K  LE I     
Sbjct: 983  WFRGFTGEV---VAVGGDRYKFSGIIRECGEKEVEITELPLRTWTQDFKDKLEEIIKAE- 1038

Query: 547  NVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAE 605
              K P  I+D+R       V   I++  + +   + EGL +KFKLT +I+T+N+  FD E
Sbjct: 1039 --KVPSFIKDYRDYNTHTKVHFIIQLDEKHMKAALSEGLEEKFKLTKSIATTNLVAFDPE 1096

Query: 606  GKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVS 665
            G+I KY   + IL+EF+ +RL YYERRKQ+ L N +R L  L N+ RF+  ++ G++V+S
Sbjct: 1097 GRITKYATVDDILKEFYVVRLKYYERRKQFQLSNLQRELEKLSNQARFVQMIIDGKLVIS 1156

Query: 666  NRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGD 725
             +KK  L+ EL++KGF P+    K AE    G                            
Sbjct: 1157 KKKKPVLITELKEKGFKPI---AKVAEAAKMGEDEAVVEEGLEEGEDESDDPNAEVLSSS 1213

Query: 726  YEYLLSMSIGTLTLESVQ 743
            ++YLL M + +LT E V+
Sbjct: 1214 FDYLLGMPMWSLTQERVE 1231


>G8BRR7_TETPH (tr|G8BRR7) DNA topoisomerase 2 OS=Tetrapisispora phaffii (strain
            ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD
            70-5) GN=TPHA0C02900 PE=3 SV=1
          Length = 1422

 Score =  711 bits (1836), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 367/722 (50%), Positives = 486/722 (67%), Gaps = 11/722 (1%)

Query: 26   ADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGLSV 85
            AD   +  LKK+DG++  R+    KLEDAN AG +   KCTLILTEGDSA +LA+AGL+V
Sbjct: 406  ADANDTNALKKSDGSRKSRITEYPKLEDANKAGTKEGYKCTLILTEGDSALSLAVAGLAV 465

Query: 86   VGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNVKSLRYGHLMI 145
            VGRD+YG +PLRGK+LNVREAS  QI+ N EIQ IKKI+GLQ  K+Y +  SLRYGHLMI
Sbjct: 466  VGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHKKKYEDASSLRYGHLMI 525

Query: 146  MADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS--NGTKLSFYSMPE 203
            M DQDHDGSHIKGL+INF+ S +P LL +P F+VEF TPII+   +  +  ++SFY+MP+
Sbjct: 526  MTDQDHDGSHIKGLIINFLESSFPGLLDIPEFLVEFITPIIKVTITKPHREQISFYNMPD 585

Query: 204  YESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWEDDYDGSAIEMAF 263
            YE WRE      T WK KYYKGLGTS+ QE REYF DL  H K F   +  D   IE+AF
Sbjct: 586  YERWREEESQKYT-WKQKYYKGLGTSSGQEVREYFADLDTHLKKFHALEGNDKDLIELAF 644

Query: 264  SKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLKPG 323
            SKKKA+DRK W+R +EPG   D     I   DF+NKELILFS AD  RSIPSV+DGLKPG
Sbjct: 645  SKKKADDRKEWLRLYEPGTVLDPTLKEIPISDFINKELILFSLADNIRSIPSVLDGLKPG 704

Query: 324  QRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLK 383
            QRK+++  FK+ L  EIKV Q   YVSE +AYHHGEQSLA TII +AQ+FVG++NI LLK
Sbjct: 705  QRKVMYGCFKRNLVSEIKVAQLAPYVSECTAYHHGEQSLAQTIISLAQNFVGASNIYLLK 764

Query: 384  PNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPII 443
            PNG FGTR  GGKD A++RYIYT+L+ ITR +FH +DD L +Y+ ED +++EP WY+PI+
Sbjct: 765  PNGAFGTRATGGKDAAAARYIYTQLSKITRKIFHPSDDTLYKYVQEDEKTVEPEWYLPIL 824

Query: 444  PLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSAKE 503
            P+VLVNG+EGIGTGWS+ IP +NP+DII N++ L+N E M  M PW+RG+ G +E+   +
Sbjct: 825  PMVLVNGTEGIGTGWSTSIPPFNPKDIIKNLKHLMNGEEMEEMHPWFRGWTGSLERIDPQ 884

Query: 504  GGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKDPLIEDFRQNGDDA 563
              Y + G +E+    +  ITELP R WT   K++L     G+   K   I+D  +   DA
Sbjct: 885  -RYRLFGKIEQTGPTTLEITELPARVWTSTIKEYLLLGLSGNDKTK-AWIKDMEEQHSDA 942

Query: 564  MVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFP 623
            +  I I++  E+++   + G   +FKL ++IS +NM  FD  GKIKKYE P++IL+EF+ 
Sbjct: 943  IKFI-IKLTPEEMSKTRKIGFYDRFKLVSSISLNNMVAFDPHGKIKKYETPQEILQEFYY 1001

Query: 624  LRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTP 683
            +RL+YY++RK Y+ E  + +L  +  +V+FI  ++  E++V+N+ K  ++ EL + GF  
Sbjct: 1002 VRLEYYQKRKDYMCERLQWVLEKISYQVKFIKMIIDRELIVTNKPKKLVIKELTELGFPR 1061

Query: 684  MPKKGKS-----AEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLT 738
            + K GK       E    G                        + G+Y+YLL M I +LT
Sbjct: 1062 INKIGKPFYGEIKEESEEGIEDVSDEESDQNGNDDSLVNGPEEQYGNYDYLLGMKIWSLT 1121

Query: 739  LE 740
             E
Sbjct: 1122 KE 1123


>D3B7U7_POLPA (tr|D3B7U7) DNA topoisomerase 2 OS=Polysphondylium pallidum GN=top2
            PE=3 SV=1
          Length = 1524

 Score =  711 bits (1836), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 372/785 (47%), Positives = 497/785 (63%), Gaps = 56/785 (7%)

Query: 7    MLQMFAVANSGILDTLLSWADFKQSKDLKK--TDGTKTQRLRGIVKLEDANDAGGRNSDK 64
             L+    + SGI+D ++S+A  K+   + +  T  TK      I KL+DAN AG  +S+ 
Sbjct: 508  FLKKIVESKSGIVDQIISYAKHKEEMAMLRNTTATTKKGSRLNIPKLDDANLAGTSHSED 567

Query: 65   CTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKIL 124
            CTLILTEGDSAK LA++G+SVVG DHYG FPLRGKLLNVRE+  + +M NEEI NI  I+
Sbjct: 568  CTLILTEGDSAKTLAVSGISVVGWDHYGCFPLRGKLLNVRESDARTMMTNEEIVNIINIM 627

Query: 125  GLQQNKEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTP 184
            GLQ  K+Y +VKSLRYGHLMIM DQDHDGSHIKGLL+NFIH FWPSLL++  F+VEF TP
Sbjct: 628  GLQHGKQYEDVKSLRYGHLMIMTDQDHDGSHIKGLLLNFIHHFWPSLLRIEGFLVEFVTP 687

Query: 185  IIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKH 244
            II+A   N T ++FY++PEY +WRE   NN  G++IKYYKGLGTST +E +EYF  L  H
Sbjct: 688  IIKATKGNKT-IAFYTIPEYLAWRE-ANNNGKGYEIKYYKGLGTSTEEEAKEYFSQLVNH 745

Query: 245  RKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVA-SRINYKDFVNKELIL 303
            + DF +++  D  AI+ AF+KK+A DRK W+  + PG Y D     ++   DF++KELIL
Sbjct: 746  KIDFEYDNGAD-DAIDKAFNKKRANDRKTWMDQYTPGAYLDQYGIKKVKITDFIDKELIL 804

Query: 304  FSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLA 363
            FS AD +RSIPS+VDG K  QRKILF  FK+ L KEIKV Q IGYVSE SAYHHG+QSLA
Sbjct: 805  FSIADCERSIPSIVDGFKTSQRKILFSCFKRNLKKEIKVAQLIGYVSEQSAYHHGDQSLA 864

Query: 364  STIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKL 423
            S IIG+AQ +VG+NNIN+L P G FG+R  GGKD ++ RYI T L  I R LF E D  L
Sbjct: 865  SAIIGLAQTYVGANNINVLYPGGGFGSRLAGGKDSSAPRYINTRLEEIARTLFPEEDHAL 924

Query: 424  LEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETM 483
            L +L +DG+ ++P WYIP+IP++LVNGS+GIGTGWSS IPNYNPRD+I N++ L+  + +
Sbjct: 925  LSHLTDDGKRVQPKWYIPVIPMILVNGSKGIGTGWSSTIPNYNPRDLIENMKLLIEGKEL 984

Query: 484  VPMDPWYRGFKGIIE-KSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESIT 542
             P+ PWYRGFKG IE ++ K   ++  G   ++DE    ITELPI  WT D+K  ++++ 
Sbjct: 985  KPIVPWYRGFKGTIELQTGKTSNFVAKGVWRKLDEYRLEITELPIESWTNDFKDLVQNLI 1044

Query: 543  D-------------------------------------GSPNVKDPLIEDFRQNGDDAMV 565
            D                                         + DP+++     G     
Sbjct: 1045 DPQGKQKRKEAKEKIKQVKKGKATSTKVVKRKKKDEDDDEVVIADPIVKSMSNQGTVG-- 1102

Query: 566  DIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLR 625
               I   +E +  + +  + K FKL   ++ +NM +FD EG+IK++E    I++ FF +R
Sbjct: 1103 --SIHFIIETLKPVDEIDVNKTFKLEKKLAETNMTVFDEEGRIKQFETTTDIIKYFFKIR 1160

Query: 626  LDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMP 685
            L+YY++RK Y+ +  E     L NK RFIL VV+ E+V++N K+ DL+ +L++  F    
Sbjct: 1161 LEYYQKRKDYLCDKLEEEHRRLSNKARFILAVVNKELVIANVKRLDLVKKLKEMKFDQFS 1220

Query: 686  KK-GKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXK------RGDYEYLLSMSIGTLT 738
            KK GK AE QV  +                              RG Y+YLLS+ + +LT
Sbjct: 1221 KKVGKKAEEQVKKSKVDKVEEELAVNSDQEEEGSDDEMEMDDDCRG-YDYLLSLPLWSLT 1279

Query: 739  LESVQ 743
            LE V+
Sbjct: 1280 LERVK 1284


>R0JC34_ANAPL (tr|R0JC34) DNA topoisomerase 2-beta (Fragment) OS=Anas platyrhynchos
            GN=Anapl_09198 PE=4 SV=1
          Length = 1605

 Score =  711 bits (1835), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 366/695 (52%), Positives = 485/695 (69%), Gaps = 24/695 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S  CTLILT
Sbjct: 405  AASNCGIIESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSLDCTLILT 464

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 465  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 524

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +KSLRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 525  SYEDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 583

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++ N+   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 584  A-SKNKQELSFYSIPEFDEWKKHMENHK-AWKIKYYKGLGTSTAKEAKEYFADMERHRIL 641

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 642  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 701

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDGLKPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 702  FINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 761

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI+T L+P+ R L
Sbjct: 762  HHGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARLL 821

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VLVNG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 822  FPSVDDNLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNVR 881

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y+V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 882  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYVVSGEIFVVDRNTVEITELPVRTWTQVYK 940

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL T+
Sbjct: 941  EQVLEPMLNGTE--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTS 998

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 999  LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLHYYSLRKEWLVGMLGAESTKLNNQARF 1058

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG 688
            IL  + G+I + NR K DL+  L Q+G+   P K 
Sbjct: 1059 ILEKIQGKITIENRSKRDLIQMLVQRGYESDPVKA 1093


>K0KT01_WICCF (tr|K0KT01) DNA topoisomerase 2 OS=Wickerhamomyces ciferrii (strain
            F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 /
            NRRL Y-1031) GN=TOP2 PE=3 SV=1
          Length = 1503

 Score =  711 bits (1835), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 364/681 (53%), Positives = 483/681 (70%), Gaps = 22/681 (3%)

Query: 16   SGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDSA 75
            S ILD   + AD    K L+KTDG+K  R+    KLEDAN AG R   KCTLILTEGDSA
Sbjct: 418  SNILDAAQANAD----KALRKTDGSKKSRITNYSKLEDANKAGTREGYKCTLILTEGDSA 473

Query: 76   KALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSNV 135
             +LA+AGL+VVGRD++G FPLRGK+LNVR+ASN QI  N EIQ IK+I+GLQ  K+Y ++
Sbjct: 474  LSLAVAGLAVVGRDYFGCFPLRGKMLNVRDASNDQITKNAEIQAIKQIMGLQHKKKYEDL 533

Query: 136  KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSNGTK 195
            KSLRYG +MIM DQD DGSHIKGL+INF+ + +P LL +P F++EF TPI++    N TK
Sbjct: 534  KSLRYGRIMIMTDQDTDGSHIKGLIINFLETSFPGLLNIPGFLLEFITPIVKV---NITK 590

Query: 196  -----LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
                 L+FY+MPEYESW EN  +  T W  KYYKGLGTS+ +EGREYF DL KH K F  
Sbjct: 591  PRRETLAFYNMPEYESWIENESHQYT-WTHKYYKGLGTSSQEEGREYFSDLEKHLKTFNP 649

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
             ++ D   I++AFSKKKA+ RK W+R F PG + D   + I   +F+NKELILFS AD  
Sbjct: 650  LEENDKGLIDLAFSKKKADHRKEWLRGFVPGTHLDIDLNEIPISEFINKELILFSMADNI 709

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPSV+DG KPGQRKIL+ SFK+ L  EIKV Q  GY+SEH+ YHHGEQSL +TI+G+A
Sbjct: 710  RSIPSVLDGFKPGQRKILYGSFKRNLKSEIKVAQLAGYISEHTGYHHGEQSLITTIVGLA 769

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDFVGSNNINLL P G FGTRN+GGKD +++RYIYTEL  ITR +F++ DD L  Y  +D
Sbjct: 770  QDFVGSNNINLLLPKGSFGTRNMGGKDASAARYIYTELATITRKIFNQTDDALYTYEQDD 829

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
            G ++EP+WY+PIIP+VLVNG+EGIGTGWS+ +P +NP D++ N++RL+N++ ++ M+PWY
Sbjct: 830  GENVEPTWYLPIIPMVLVNGAEGIGTGWSTNVPQFNPADLVENMKRLMNNQELLEMEPWY 889

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            +G+ G I+K   +  Y V G +E++D+ +  ITELP++ WT   K+ L     GS  VK 
Sbjct: 890  KGWDGQIQKIGPD-KYKVYGKIEKLDDNTLAITELPVKTWTASVKEQLLLGLGGSDKVK- 947

Query: 551  PLIEDFR-QNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTTISTSNMHLFDAEGK 607
            P I+D + Q+G    + I   + L    M   E  GL ++FKL + I+ SNM LFD +G+
Sbjct: 948  PWIKDMQEQHG----LGIRFIVTLSDAEMKKSEEIGLYERFKLHSVINLSNMVLFDPQGR 1003

Query: 608  IKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNR 667
            IKKYE  ++IL++F+ +RLDYY+RRK  + +     L  L ++ RFI  ++  ++ ++NR
Sbjct: 1004 IKKYETVDEILKDFYYVRLDYYQRRKDNLAKELSNHLEKLSSQARFIKLIIDKKLNINNR 1063

Query: 668  KKADLLMELQQKGFTPMPKKG 688
            K+ DL+  LQ+  F    KKG
Sbjct: 1064 KRVDLIENLQELNFPKFDKKG 1084


>G8YUD2_PICSO (tr|G8YUD2) DNA topoisomerase 2 OS=Pichia sorbitophila (strain ATCC
            MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
            Y-12695) GN=Piso0_000036 PE=3 SV=1
          Length = 1409

 Score =  711 bits (1834), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 346/682 (50%), Positives = 483/682 (70%), Gaps = 7/682 (1%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            + N+ I+D + +    ++  +L+K DG++  R++  VKL DAN AG +   KCTLILTEG
Sbjct: 435  IMNTSIVDIIKAARSAREDIELQKADGSRKSRIKNQVKLVDANKAGTKEGHKCTLILTEG 494

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSA +LA+AGL+VVGR++YG FPLRGKLLNVREAS  QI  N EI  +K+I+GL+    Y
Sbjct: 495  DSALSLAVAGLAVVGRNYYGCFPLRGKLLNVREASADQIAKNAEINALKQIIGLKHKVHY 554

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
            S  N+K LRYGH+MIM DQDHDGSHIKGL+INF+ + +P LL++P F++EF TPI++ F 
Sbjct: 555  SLENIKDLRYGHIMIMTDQDHDGSHIKGLIINFLDTSFPGLLQIPGFLLEFITPIVKVFL 614

Query: 191  SNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             N   LSFY+MPE+E WRE  G     W+ KYYKGLGTST  EGREYF  L +H K F  
Sbjct: 615  KNKKVLSFYTMPEFEQWRETEGKTQR-WRHKYYKGLGTSTLMEGREYFAALDRHLKKFHA 673

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
                D S+I++AFSKKKA+DRK W++ FEPG + D +   I   DF+NKELILFS AD  
Sbjct: 674  LQGDDKSSIDLAFSKKKADDRKEWLQCFEPGTHLDPLLQEIPISDFINKELILFSMADNI 733

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPSV+DGLKPGQRK+L+  F++ L  +IKV Q  GYVSE++ YHHGE SL  TIIG+A
Sbjct: 734  RSIPSVLDGLKPGQRKVLYACFRRNLTVDIKVSQLAGYVSENTGYHHGEASLVQTIIGLA 793

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            QDF+GSNN+N+LKP G FG+R  GGKD +++RYI+T+L+ IT+ +F+  D+ L  Y+ ED
Sbjct: 794  QDFIGSNNLNVLKPIGTFGSRAAGGKDFSAARYIFTQLSEITKKVFNPLDNPLYTYVQED 853

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
              ++EP WY+P++P+VLVNG+EGIGTGWS+ IP +NP DI+ N+RRL+  E M+PM PW+
Sbjct: 854  EGTVEPEWYLPVLPMVLVNGAEGIGTGWSTNIPPFNPTDIVQNIRRLMAGEEMIPMTPWF 913

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            +G++G I+  +++  + V GT+E+ID  +  I+E+P + W  + K+FL S  D   +   
Sbjct: 914  KGWEGEIQPISQD-KFRVMGTIEQIDNTTLEISEIPPKTWINNMKEFLLSGLDSKKD--K 970

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKK 610
            P I+D  ++     +   I++  E++A   + GLL++FKL + I+ SNM LFD  G+IKK
Sbjct: 971  PWIKDVEEH-HGMNIKFIIKLSEEEMAKSHKIGLLERFKLISVINLSNMVLFDPSGRIKK 1029

Query: 611  YENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKA 670
            YE+P QIL EFF +RL+YY+RRK ++ +  +  LL L  + RFI  ++  +I +SN+K++
Sbjct: 1030 YESPLQILREFFYVRLEYYQRRKDFLTDKLQNQLLKLSEQARFIKHIIDNKISLSNKKRS 1089

Query: 671  DLLMELQQKGFTPMPKKGKSAE 692
             L+ +LQ+  F    K GK  +
Sbjct: 1090 VLVKQLQELDFAMFDKDGKKVQ 1111


>H2QM73_PANTR (tr|H2QM73) DNA topoisomerase 2 OS=Pan troglodytes GN=TOP2B PE=3 SV=1
          Length = 1621

 Score =  709 bits (1831), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 377/751 (50%), Positives = 501/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 417  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 476

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 477  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 536

Query: 131  EYSNVKSL---RYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y + KSL   RYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 537  SYDDAKSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 595

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 596  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 653

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 654  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 713

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 714  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 773

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 774  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 833

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 834  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 893

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 894  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 952

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 953  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 1010

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1011 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1070

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1071 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1130

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1131 GTPSGP------DFNYILNMSLWSLTKEKVE 1155


>H9F8L1_MACMU (tr|H9F8L1) DNA topoisomerase 2 (Fragment) OS=Macaca mulatta GN=TOP2B
            PE=2 SV=1
          Length = 1594

 Score =  709 bits (1830), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 390  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 449

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 450  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 509

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 510  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 568

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 569  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 626

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 627  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 686

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 687  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 746

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 747  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 806

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 807  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 866

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 867  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 925

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 926  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 983

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 984  LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1043

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1044 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1103

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1104 GTPSGP------DFNYILNMSLWSLTKEKVE 1128


>L8WTI6_9HOMO (tr|L8WTI6) DNA topoisomerase 2 OS=Rhizoctonia solani AG-1 IA
            GN=AG1IA_04517 PE=3 SV=1
          Length = 1447

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 362/688 (52%), Positives = 464/688 (67%), Gaps = 51/688 (7%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
             VA SGI+D +LSWA FK  ++ KKTDGTK  RL GI KL DAN+AGGR++ +CTLILTE
Sbjct: 508  TVAKSGIIDNVLSWAKFKADQENKKTDGTKRTRLTGIAKLSDANNAGGRHASECTLILTE 567

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK+LA AGLSV GR+++G+FPLRGKLLNVREA++ Q+M N EIQ IK+I+GL+    
Sbjct: 568  GDSAKSLAEAGLSVAGRNNFGIFPLRGKLLNVREATHDQVMKNAEIQAIKQIMGLKHGVA 627

Query: 132  YSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
            Y +V SLRYG +MIM DQ   G+                                     
Sbjct: 628  YKDVGSLRYGSIMIMTDQVTKGNQ------------------------------------ 651

Query: 192  NGTKLSFYSMPEYESWRENLGNNATG-WKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
               K++F+++PE++ W E   NN  G W +KYYKGLGTS   + REYF  + KH   F  
Sbjct: 652  ---KINFFTIPEFQKWNEE--NNKDGKWYVKYYKGLGTSKDSDAREYFGAMEKHMIPFAK 706

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
             ++ +   I+MAF+KKKA+DRK W+R F+PG + DH    I Y DF+N+ELILFS AD  
Sbjct: 707  TEEGERELIDMAFNKKKADDRKDWLRQFKPGTFIDHSVQEITYSDFINRELILFSMADNI 766

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIPSVVDGLKPGQRK++F +FK+KL  EIKV Q +GY+SE +AYHHGEQSL  TI+ +A
Sbjct: 767  RSIPSVVDGLKPGQRKVIFGTFKRKLKNEIKVAQLVGYISEKTAYHHGEQSLTMTIVNLA 826

Query: 371  QDFVGSNNINLLKPNGQFGTRN------LGGKDHASSRYIYTELNPITRCLFHENDDKLL 424
            Q+FVGSNNINLLKP GQFGTR+       GGKD AS+RYI+T +  ITR +FH +DD LL
Sbjct: 827  QNFVGSNNINLLKPEGQFGTRSQCTYFIQGGKDAASARYIFTSIPHITRTIFHPHDDALL 886

Query: 425  EYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMV 484
             YL +D  SIEP WY+PI+P++L+NG++GIGTGWS+ IPNYNPRDI+ N++RL+N E  V
Sbjct: 887  NYLKDDNDSIEPEWYMPILPVILINGADGIGTGWSTSIPNYNPRDIVDNIKRLMNGEPQV 946

Query: 485  PMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDG 544
            PM PWYRGFKG IEK   E  Y V+G VE    +   I ELPIR WTQ YK+ LE    G
Sbjct: 947  PMFPWYRGFKGNIEKIG-EDKYKVSGIVERT-AKGVDIKELPIRVWTQSYKEQLEEWLVG 1004

Query: 545  SPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDA 604
            +     P ++D+ ++     V  E+ +  + +     EG  K FKL   ISTSNM  FDA
Sbjct: 1005 TQK-SPPFVKDYHEHHTTRSVYFELTVAEKDLEKAETEGFEKFFKLVAQISTSNMICFDA 1063

Query: 605  EGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVV 664
             GKIKKY +PE+ILEEF+ LRL YY++RKQ++ +  ER    L N+ RF+  ++  E+VV
Sbjct: 1064 NGKIKKYNSPEEILEEFYALRLSYYQKRKQHLCDELERQYEKLSNQARFVNMIIKKELVV 1123

Query: 665  SNRKKADLLMELQQKGFTPMPKKGKSAE 692
            SN+KKADL  EL++  F P PK  K+ E
Sbjct: 1124 SNKKKADLCAELRELKFRPFPKVRKAKE 1151


>G8BHF5_CANPC (tr|G8BHF5) DNA topoisomerase 2 OS=Candida parapsilosis (strain CDC
            317 / ATCC MYA-4646) GN=CPAR2_501050 PE=3 SV=1
          Length = 1443

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 352/688 (51%), Positives = 484/688 (70%), Gaps = 16/688 (2%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  +GI D +   A+  + K L+K DG++  R++G V L DAN AG R+  KCTLILTEG
Sbjct: 445  VLKTGIADKIRDIANANEDKALQKVDGSRKSRIKGQVNLVDANKAGTRDGLKCTLILTEG 504

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
             SA  LA+AGL+V+GRD+YG FPLRGKLLNVREAS  QI  N EI ++K+I+GLQ  K Y
Sbjct: 505  LSALNLAVAGLTVIGRDYYGCFPLRGKLLNVREASADQIAKNAEINSLKQIIGLQHKKTY 564

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA-F 189
            +  N+KSLRYGH+MIM DQD DGSHIKGL+INF+ + +P LL +P F++EF TPI++   
Sbjct: 565  NAENIKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLEFITPIVKVTV 624

Query: 190  HSNGTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
               G K  + FYSMPE+E+WR+  G     W  KYYKGLGTSTP E REYF  L +H K 
Sbjct: 625  KGRGAKKIIPFYSMPEFETWRDGEGQTCR-WTQKYYKGLGTSTPMEAREYFTALDRHLKR 683

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F      D S I++AFSKKKA++RK W++NF PGN  D   + I   +F+NKELILFS +
Sbjct: 684  FHALQGEDSSCIDLAFSKKKADERKEWLQNFVPGNQLDPALNEIPISEFINKELILFSMS 743

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSV+DGLKPGQRK+LF  FK+ L  EIKV Q   YVSE++ YHHGE SL  TII
Sbjct: 744  DNIRSIPSVLDGLKPGQRKVLFGCFKRNLKSEIKVAQLAAYVSENTGYHHGEVSLVQTII 803

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ+FVGSNNIN+LKPNG FG+R  GGKD A++RYI+TELN IT+ +F+  D+ +  Y+
Sbjct: 804  GLAQNFVGSNNINILKPNGAFGSRATGGKDAAAARYIFTELNDITKAIFNPLDNPIYTYV 863

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +D +++EP WY+P++P++LVNG+EGIGTGWS+ IP+Y+P++I+AN+RRL+N+E +  M 
Sbjct: 864  QDDEQTVEPQWYLPVLPMILVNGAEGIGTGWSTNIPSYDPKEIVANLRRLMNNEPLEEMM 923

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWY+G+ G+IE   ++  Y ++G +E+ID+    ITE+P++ WT   K+FL +   G  N
Sbjct: 924  PWYKGWDGVIEPMGQQ-KYKISGKIEQIDDNIVEITEIPVKTWTNTVKEFLLA---GFGN 979

Query: 548  VKDPL-IEDFRQNGDDAMVDIEIRMKLEKIAM--IMQEGLLKKFKLTTTISTSNMHLFDA 604
             K P  I+D  ++      +I   +KL    M   ++ GLL+KFKL ++IS  NM  FD 
Sbjct: 980  EKTPAWIKDMEEH---HTTNIRFVVKLSDAEMEKALKVGLLEKFKLISSISLGNMVAFDP 1036

Query: 605  EGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVV 664
             G+IKKY +  +IL++F+ +RL+YYE+RK ++LE  +R LL++  + RF+  ++  E+ V
Sbjct: 1037 YGRIKKYNDVFEILKDFYYVRLEYYEKRKNHMLEMLQRKLLMISEQARFVKMIIEKELSV 1096

Query: 665  SNRKKADLLMELQQKGFTPMPKKGKSAE 692
            +N+KK DL+  L++  FT   K G   E
Sbjct: 1097 ANKKKKDLIELLEKHDFTKFTKDGTPVE 1124


>G1XKF5_ARTOA (tr|G1XKF5) DNA topoisomerase 2 OS=Arthrobotrys oligospora (strain
            ATCC 24927 / CBS 115.81 / DSM 1491) GN=AOL_s00109g184
            PE=3 SV=1
          Length = 1586

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 384/820 (46%), Positives = 503/820 (61%), Gaps = 34/820 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  SGI + L   A  K    LKKTDG++  R+    KL DAN AG ++  +CTLILTEG
Sbjct: 515  VVRSGIKEALSDTAQTKTDALLKKTDGSRRARIVN-SKLVDANKAGTKDGWQCTLILTEG 573

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSAKALAM+G+ VVGRD +GVFPLRGK+LNVR+A   QI  N EIQNIK+ILGLQ  K Y
Sbjct: 574  DSAKALAMSGMEVVGRDLFGVFPLRGKMLNVRDAPADQIAKNAEIQNIKQILGLQHKKTY 633

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFH 190
               N+K LRYGHLMIM DQDHDGSHIKGLLINF+ + + SLLK+  F++EF TPI++A+ 
Sbjct: 634  DEKNIKDLRYGHLMIMTDQDHDGSHIKGLLINFLDAQFASLLKIDGFLLEFITPIVKAYK 693

Query: 191  SNGTK----LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRK 246
               TK     +F++MPEYE W+E   N   GW+ KYYKGLGTS+  E +EYF DL KH K
Sbjct: 694  GVVTKPTKSRAFFTMPEYEEWKET--NTEKGWQTKYYKGLGTSSSAEAKEYFSDLDKHLK 751

Query: 247  DFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSR 306
            +F      +   I+M FSKKK E+RK W+R + PG Y DH   +I+Y DF+NKELILFS 
Sbjct: 752  EFHSMKLEERGLIDMVFSKKKIEERKEWLRQYRPGVYLDHSIEKISYDDFINKELILFSM 811

Query: 307  ADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTI 366
            AD  RSIPS +DGLKPGQRK+LF  FKKKL KE+KV    GYV +H+ Y HG+ SLA TI
Sbjct: 812  ADNIRSIPSAIDGLKPGQRKVLFGCFKKKLSKEVKVQSLAGYVLDHTHYQHGDVSLAQTI 871

Query: 367  IGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEY 426
            I +AQ FVGSNN+N+L+P G FG+R  GGKD AS+RYI T L+P  R LF   DD +LEY
Sbjct: 872  IALAQTFVGSNNVNILEPIGNFGSRLGGGKDAASARYISTMLSPFARALFPAADDAILEY 931

Query: 427  LNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPM 486
              EDG  IEP+WY P++PL+L+NGS+GIGTGWSS IPNYNP D+  N+RRLL+D+ + PM
Sbjct: 932  NYEDGDKIEPNWYAPVLPLILMNGSDGIGTGWSSSIPNYNPEDVAMNIRRLLDDQDLEPM 991

Query: 487  DPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESI----- 541
             PWYRGFKG +E+   E  Y  +G + ++++ +  ITELP+R WTQ++K+ L+ I     
Sbjct: 992  QPWYRGFKGRLERLTPE-KYQFSGIINQVNDTTVEITELPVRLWTQEFKEKLDDIIKPPE 1050

Query: 542  ------TDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLE-KIAMIMQEGLLKKFKLTTTI 594
                        V+   I+D+     D  V   + +  +  +   ++EGL  +FKL  T 
Sbjct: 1051 KDGKDKDKKVTKVEKAWIKDYLDYNSDLRVHFIVELDSKASMEAALKEGLETRFKLNKTA 1110

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            ST+NM  FDA+G++ +YE PE IL+EF+ +RL  Y+ RK Y+L    + L  L N+ RF+
Sbjct: 1111 STTNMVAFDAQGRLTRYETPEDILKEFYFVRLKLYQSRKDYLLGELNKQLRKLTNQARFV 1170

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXX 714
              ++  E+VVSN+K+A L+ EL+ + F  +  K ++ E                      
Sbjct: 1171 QMIIKKELVVSNKKRAVLIAELRSQKFDVISNKKEAEE-----------SGETEPIVEEN 1219

Query: 715  XXXXXXXKRGD-YEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATPSKSMWMXXXX 773
                     GD + YLL M I +LT E V+                     K +W     
Sbjct: 1220 EEITGGDDVGDGFNYLLGMPIWSLTKEKVEKLLAECGTKEGEIDTLAKRSPKDLWREDLD 1279

Query: 774  XXXXXXXXQDGKEAEDEKKRISQASKRTSTRDLGTKAAKK 813
                    Q  ++ E   KR +    R      G  AAKK
Sbjct: 1280 VFMEEWYKQLKEDQERATKRSALKKSRKVKTTAGKAAAKK 1319


>F7E5A9_MACMU (tr|F7E5A9) DNA topoisomerase 2 OS=Macaca mulatta GN=TOP2B PE=2 SV=1
          Length = 1626

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 422  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 481

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 482  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 541

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 542  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 600

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 601  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 658

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 659  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 718

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 719  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 778

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 779  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 838

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 839  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 898

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 899  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 957

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 958  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 1015

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1016 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1075

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1076 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1135

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1136 GTPSGP------DFNYILNMSLWSLTKEKVE 1160


>K7CLW1_PANTR (tr|K7CLW1) DNA topoisomerase 2 OS=Pan troglodytes GN=TOP2B PE=2 SV=1
          Length = 1621

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 417  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 476

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 477  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 536

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 537  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 595

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 596  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 653

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 654  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 713

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 714  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 773

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 774  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 833

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 834  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 893

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 894  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 952

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 953  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 1010

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1011 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1070

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1071 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1130

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1131 GTPSGP------DFNYILNMSLWSLTKEKVE 1155


>I2CT72_MACMU (tr|I2CT72) DNA topoisomerase 2 OS=Macaca mulatta GN=TOP2B PE=2 SV=1
          Length = 1621

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 417  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 476

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 477  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 536

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 537  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 595

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 596  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 653

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 654  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 713

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 714  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 773

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 774  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 833

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 834  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 893

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 894  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 952

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 953  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 1010

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1011 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1070

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1071 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1130

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1131 GTPSGP------DFNYILNMSLWSLTKEKVE 1155


>G3SGP2_GORGO (tr|G3SGP2) DNA topoisomerase 2 OS=Gorilla gorilla gorilla GN=TOP2B
            PE=3 SV=1
          Length = 1516

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 374/754 (49%), Positives = 502/754 (66%), Gaps = 29/754 (3%)

Query: 8    LQMFAVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCT 66
            ++ F  +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CT
Sbjct: 372  VKPFQASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECT 431

Query: 67   LILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGL 126
            LILTEGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GL
Sbjct: 432  LILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGL 491

Query: 127  QQNKEYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTT 183
            Q  K Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF T
Sbjct: 492  QYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFIT 550

Query: 184  PIIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGK 243
            PI++A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +
Sbjct: 551  PIVKA-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMER 608

Query: 244  HRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-I 291
            HR  F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ +
Sbjct: 609  HRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHL 668

Query: 292  NYKDFVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSE 351
             Y DF+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E
Sbjct: 669  TYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAE 728

Query: 352  HSAYHHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPI 411
             SAYHHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ +
Sbjct: 729  MSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTL 788

Query: 412  TRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDII 471
             R LF   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+
Sbjct: 789  ARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIV 848

Query: 472  ANVRRLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWT 531
             NVRR+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WT
Sbjct: 849  NNVRRMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWT 907

Query: 532  QDYK-QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKL 590
            Q YK Q LE + +G+      LI D+++   D  V   ++M  EK+A     GL K FKL
Sbjct: 908  QVYKEQVLEPMLNGTDKTP-ALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKL 966

Query: 591  TTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNK 650
             TT++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+
Sbjct: 967  QTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQ 1026

Query: 651  VRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXX 709
             RFIL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A             
Sbjct: 1027 ARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSS 1086

Query: 710  XXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                           D+ Y+L+MS+ +LT E V+
Sbjct: 1087 SDSGTPSGP------DFNYILNMSLWSLTKEKVE 1114


>K0TQD1_THAOC (tr|K0TQD1) DNA topoisomerase 2 OS=Thalassiosira oceanica
            GN=THAOC_02435 PE=3 SV=1
          Length = 1391

 Score =  709 bits (1829), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 389/824 (47%), Positives = 518/824 (62%), Gaps = 58/824 (7%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            AV  SG++D+++ +A FK ++ LK+  GTK  +L GI KL+DAN+AG   S  CTLI+TE
Sbjct: 419  AVEKSGVVDSIMQFAKFKANQALKRKGGTKKTKLTGITKLDDANNAGTAKSKDCTLIITE 478

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK+LA++GLSVVGRD YGVFPL+GK LNVR+A++ QIM NEEI N+ +I+GL+    
Sbjct: 479  GDSAKSLAVSGLSVVGRDFYGVFPLKGKPLNVRDATHAQIMKNEEIMNLVEIMGLKFGTT 538

Query: 132  YS--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            YS  N+KSLRYGHLMIMADQDHDGSHIKGL+INFIH FWPSLL VP F+ +F TPI++  
Sbjct: 539  YSEENIKSLRYGHLMIMADQDHDGSHIKGLVINFIHHFWPSLLDVPGFLQQFITPIVKCT 598

Query: 190  HSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEG---REYFRDLGKHR- 245
                ++ +F+++PEYE W+E  GN+A GW  KYYKGLGTST  EG   +EYF +L  H  
Sbjct: 599  KGKKSE-TFFTLPEYEEWKEGTGNDAKGWTTKYYKGLGTSTSSEGKTSKEYFSNLDIHEI 657

Query: 246  --------------KDFVWEDDYDGSA---IEMAFSKKKAEDRKVWIRNFEPG---NYRD 285
                           D   EDD+  S    I+MAFSK K E+RKVW+   E     +Y +
Sbjct: 658  HFNEISSDVGDVDDADMEVEDDFVTSGAGLIDMAFSKAKVEERKVWLNRVEKDTFLHYSN 717

Query: 286  HVASRINYKDFVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQF 345
                 +NY +F+NKEL+LFS+ D  RSIP ++DGLKP QRK+LF  FKKKL  EIKV Q 
Sbjct: 718  AQTRGVNYSEFINKELVLFSQYDNIRSIPHIMDGLKPSQRKVLFACFKKKLKNEIKVAQL 777

Query: 346  IGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIY 405
             GY+ EHSAYHHGE SL  T+IGMAQ + GSNNINLL P+         GKDHAS+RYI+
Sbjct: 778  AGYIGEHSAYHHGEMSLNGTVIGMAQSYCGSNNINLLYPS---------GKDHASARYIF 828

Query: 406  TELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNY 465
            T L  ITR +FH +DD LL YLN+DG SIEP +Y+P+IPLVLVNGS+GIGTGWS+ I N+
Sbjct: 829  TRLEKITRTIFHPDDDALLTYLNDDGLSIEPEYYMPVIPLVLVNGSDGIGTGWSTTIQNH 888

Query: 466  NPRDIIANVRRLLNDETMVPMDPWYRGFKGII--EKSAKEGGYIVNGTVEEIDEQSFRIT 523
            +PR++I+N+R++++ +    M P + G+ G I  E   ++G YIV G +E   + +  IT
Sbjct: 889  DPREVISNLRKMIHGDEPEMMHPHFYGYTGEITAETGKRQGSYIVRGKIERTSDTTLLIT 948

Query: 524  ELPIRKWTQDYKQFLESI---TDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIM 580
            ELPI KWTQDYK FLE +   TD SP+     I DF++N  D  V   +    +KI    
Sbjct: 949  ELPIGKWTQDYKGFLEGLMSGTDKSPSE----ISDFKENHTDTTVSFTVTTTKDKIDSFE 1004

Query: 581  --QEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILE 638
              ++GL  KFKL+TTIST NM LFD +GKI++Y+    IL  FF  RL++Y +RK  +LE
Sbjct: 1005 KGKDGLHGKFKLSTTISTKNMTLFDDQGKIRRYQTSVDILRTFFDHRLEFYVKRKGMLLE 1064

Query: 639  NFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGA 698
               R L +L+NK RF+  V + E+VVSNRK+ +LL +L+++G+   PK  K  + +    
Sbjct: 1065 KMGRELSILENKARFVEEVCNEELVVSNRKRKELLHDLKERGYDLFPKDEKKRDDEEDDD 1124

Query: 699  XXXXXXXXXXXXXXXXXXXXXXXKRGDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXX 758
                                       +EYLL M I +LT E  +               
Sbjct: 1125 EASVEESASDADLAKG-----------FEYLLGMKIWSLTHERAEELRRQRAEKADEVDE 1173

Query: 759  XXATPSKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKRTS 802
              AT  + +W             +D   A D K+ ++  +K ++
Sbjct: 1174 LNATSPEQLWSNDLDAIDEALTERDADIAADLKEEMNAQAKNSA 1217


>G1QUD9_NOMLE (tr|G1QUD9) DNA topoisomerase 2 OS=Nomascus leucogenys
            GN=LOC100596241 PE=3 SV=2
          Length = 1621

 Score =  708 bits (1828), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 417  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 476

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 477  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 536

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 537  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 595

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 596  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 653

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 654  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 713

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 714  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 773

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 774  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 833

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 834  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 893

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 894  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 952

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 953  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 1010

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1011 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1070

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1071 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1130

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1131 GTPSGP------DFNYILNMSLWSLTKEKVE 1155


>H2PBB5_PONAB (tr|H2PBB5) DNA topoisomerase 2 OS=Pongo abelii GN=TOP2B PE=3 SV=1
          Length = 1621

 Score =  708 bits (1828), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 417  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 476

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 477  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 536

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 537  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 595

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 596  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 653

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 654  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 713

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 714  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 773

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 774  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 833

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 834  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 893

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 894  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 952

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 953  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 1010

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 1011 LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1070

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1071 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1130

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1131 GTPSGP------DFNYILNMSLWSLTKEKVE 1155


>Q7PWM2_ANOGA (tr|Q7PWM2) DNA topoisomerase 2 (Fragment) OS=Anopheles gambiae
            GN=AGAP008917 PE=3 SV=4
          Length = 1427

 Score =  708 bits (1828), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 360/692 (52%), Positives = 481/692 (69%), Gaps = 22/692 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            AV+ SGI++++L WA FK   DL KT G+K  +++GI KLEDANDAG RNS  CTLILTE
Sbjct: 380  AVSKSGIVESVLQWAKFKAQTDLAKTSGSKKSKIKGIPKLEDANDAGSRNSLNCTLILTE 439

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK LA++GL VVGRD YGVFPLRGKLLNVREA++KQI++N EI N+ KILGLQ  K+
Sbjct: 440  GDSAKTLAVSGLGVVGRDTYGVFPLRGKLLNVREATHKQILENAEINNLIKILGLQYKKK 499

Query: 132  Y---SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA 188
            Y    ++K+LRYG +MIM DQD DGSHIKGLLINFIH+ WP LL++P F+ EF TPI++A
Sbjct: 500  YLTMDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKA 558

Query: 189  FHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
               NG +LSF+S+PE+E W+    N+ T + IKYYKGLGTST +E +EYF+++ +HR  F
Sbjct: 559  TKKNGEELSFFSLPEFEEWKAETANSHT-YNIKYYKGLGTSTSKEAKEYFQNMERHRILF 617

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIR-NFEPGNYRDHVA-----------SRINYKDF 296
             +ED  D  AI +AFSKK  E RK W+  + E   +R  V              I+YKDF
Sbjct: 618  RYEDTGDDDAIMLAFSKKAIEQRKDWLTAHMEECRHRKSVGLQERYLYTKTTKEISYKDF 677

Query: 297  VNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYH 356
            VN EL+LFS +D  RSIP ++DGLKPGQRK+L+  FK+   +E+KV Q  G V+E SAYH
Sbjct: 678  VNLELVLFSNSDNVRSIPCMLDGLKPGQRKVLYTCFKRDDKREVKVAQLAGSVAEKSAYH 737

Query: 357  HGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLF 416
            HGE SL STII +AQ++VGSNNINLL P GQFGTR  GGKD AS RYI+T L+ +TR +F
Sbjct: 738  HGEMSLCSTIINLAQNYVGSNNINLLYPGGQFGTRLTGGKDSASPRYIFTMLSALTRHIF 797

Query: 417  HENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRR 476
            H  DD LLEY  ED + IEP WY+PIIP++L+NG++GIGTGW++ IPN+NPRD+IAN+RR
Sbjct: 798  HPLDDPLLEYQYEDNQRIEPVWYLPIIPMLLINGADGIGTGWATKIPNHNPRDVIANIRR 857

Query: 477  LLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ 536
            +LN +    + PWY+ F+G+IE S     Y+  GTV  +D +   I+ELPI  WTQ YK+
Sbjct: 858  MLNGDEPKMLTPWYKNFRGVIE-SVGHQKYLTAGTVGLLDGKKIEISELPIGTWTQTYKE 916

Query: 537  -FLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQE--GLLKKFKLTTT 593
              LE +  GS   K  +I D+++   D  V   I     +   +  E  G  + FKLT++
Sbjct: 917  NVLEPLLHGSDKAK-AVIADYKEYNTDTTVRFVISFLPGEYEKLYAEEGGFHRLFKLTSS 975

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            IST++M+ FD +  +K+Y +  +I  EF+ +RLD+Y +R+ Y+L   +     L +K RF
Sbjct: 976  ISTASMNAFDDKNYLKRYAHANEIFMEFYTVRLDFYGKRRAYLLGMLQAEADSLSDKARF 1035

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMP 685
            I+   +G +VV N+K+  L+ EL ++G+   P
Sbjct: 1036 IMEKCNGTLVVENKKRKALIDELIKRGYRADP 1067


>Q71UH4_HUMAN (tr|Q71UH4) DNA topoisomerase 2 (Fragment) OS=Homo sapiens GN=TOP2B
            PE=3 SV=1
          Length = 1598

 Score =  708 bits (1827), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 503/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 394  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 453

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 454  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 513

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 514  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 572

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 573  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 630

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 631  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 690

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 691  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 750

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 751  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 810

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 811  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 870

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 871  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 929

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V+  ++M  EK+A     GL K FKL TT
Sbjct: 930  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVNSVVKMTEEKLAQAEAAGLHKVFKLQTT 987

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 988  LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1047

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1048 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1107

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1108 GTPSGP------DFNYILNMSLWSLTKEKVE 1132


>H8WZH4_CANO9 (tr|H8WZH4) DNA topoisomerase 2 OS=Candida orthopsilosis (strain
            90-125) GN=CORT_0B01230 PE=3 SV=1
          Length = 1473

 Score =  708 bits (1827), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 361/750 (48%), Positives = 501/750 (66%), Gaps = 30/750 (4%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            V  +GI + +   A+  + K L+K DG++  R++G V L DAN AG ++  KCTLILTEG
Sbjct: 478  VLRTGIAEKIRDIANANEDKALQKVDGSRKSRIKGQVNLVDANKAGTKDGTKCTLILTEG 537

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
             SA  LA+AGL+V+GRD+YG FPLRGKLLNVREAS  QI  N EI ++K+I+GLQ  K Y
Sbjct: 538  LSALNLAVAGLTVIGRDYYGCFPLRGKLLNVREASADQIAKNAEINSLKQIIGLQHKKAY 597

Query: 133  S--NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA-F 189
            +  N+KSLRYGH+MIM DQD DGSHIKGL+INF+ + +P LL +P F++EF TPI++   
Sbjct: 598  TAENIKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLEFITPIVKVTV 657

Query: 190  HSNGTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
               G K  + FYSMPE+E+WR+  G     W  KYYKGLGTSTP E REYF  L +H K 
Sbjct: 658  KGRGAKKVIPFYSMPEFEAWRDGEGQTCR-WTQKYYKGLGTSTPMEAREYFTALDRHLKR 716

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRA 307
            F      D + I++AFSKKKA++RK W++NF PGN  D   + I   +F+NKELILFS +
Sbjct: 717  FHALQGEDSNYIDLAFSKKKADERKEWLQNFVPGNQLDPELNEIPISEFINKELILFSMS 776

Query: 308  DLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTII 367
            D  RSIPSV+DGLKPGQRK+LF  FK+ L  EIKV Q   YVSE++ YHHGE SL  TII
Sbjct: 777  DNIRSIPSVLDGLKPGQRKVLFGCFKRNLKSEIKVAQLAAYVSENTGYHHGEVSLVQTII 836

Query: 368  GMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYL 427
            G+AQ+FVGSNNIN+LKPNG FG+R  GGKD A++RYI+TELN IT+ +F+  D+ +  Y+
Sbjct: 837  GLAQNFVGSNNINILKPNGAFGSRATGGKDAAAARYIFTELNDITKAIFNPLDNPIYTYV 896

Query: 428  NEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMD 487
             +D +++EP WY+P++P++LVNG+EGIGTGWS+ IP+++P+DI+ N+RRL+N+E +  M 
Sbjct: 897  QDDEQTVEPQWYLPVLPMILVNGAEGIGTGWSTNIPSFDPKDIVVNLRRLMNNEPLEEMT 956

Query: 488  PWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPN 547
            PWY+G+ G IE   ++  Y ++G +E+ID  +  ITE+P++ WT   K+FL +   G  N
Sbjct: 957  PWYKGWGGFIEPMGQQ-KYKISGRIEQIDNNTVEITEIPVKTWTNTVKEFLLA---GFGN 1012

Query: 548  VKDPL-IEDFRQNGDDAMVDIEIRMKLEKIAM--IMQEGLLKKFKLTTTISTSNMHLFDA 604
             K P  I+D  ++      +I   +KL    M   ++ GLL+KFKLT+++S +NM  FD 
Sbjct: 1013 EKTPAWIKDMEEH---HTTNIRFIVKLNDAEMEKALKVGLLEKFKLTSSVSLANMVAFDP 1069

Query: 605  EGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVV 664
             G+IKKY +  +IL++F+ +RL+YYE+RK ++LE  +R LL++  + RF+  ++  E+ V
Sbjct: 1070 YGRIKKYNDVFEILKDFYYVRLEYYEKRKNHMLEMLQRKLLMISEQARFVKMIIEKELSV 1129

Query: 665  SNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXXXXXXXXXKRG 724
            +N+KK DL+  L+Q  FT   K GK  E + +                         K  
Sbjct: 1130 ANKKKKDLIELLEQHEFTKFTKDGKPVESKSSDVFIDENDSEEEIENEGDVSALNLKKSD 1189

Query: 725  D--------------YEYLLSMSIGTLTLE 740
            D              Y+YLL M+I +LT E
Sbjct: 1190 DRVEGEHKPDTIFSSYDYLLGMTIWSLTHE 1219


>F1KQU1_ASCSU (tr|F1KQU1) DNA topoisomerase 2 OS=Ascaris suum PE=2 SV=1
          Length = 1388

 Score =  708 bits (1827), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 381/817 (46%), Positives = 514/817 (62%), Gaps = 33/817 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            +V   GI++ +++W  FKQ + L KK    +T +L+G+ KLEDANDAG +NS  CTLILT
Sbjct: 455  SVMKCGIVEAVMAWVRFKQQETLDKKCSSKRTSKLKGVPKLEDANDAGTKNSSLCTLILT 514

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL VVGRD YGVFPLRGK+LNVRE ++KQIM+N EI  + KI+GLQ   
Sbjct: 515  EGDSAKSLAVSGLGVVGRDRYGVFPLRGKMLNVREGNHKQIMENAEINALIKIIGLQYRL 574

Query: 131  EYS---NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
            +Y    ++K+LRYG +M+MADQD DGSHIKGL+INFIH  WP+L++  +F+ EF TPI++
Sbjct: 575  KYDKDDDMKTLRYGKVMVMADQDQDGSHIKGLVINFIHYNWPALIR-RNFVEEFITPIVK 633

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A      + SF+S+PEY  WR N   N   ++IKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 634  ATKGK-EEYSFFSLPEYNEWRNNT-ENWKSYRIKYYKGLGTSTSKEAKEYFTDMARHRIR 691

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNF--------EPGNYRDHVASR----INYKD 295
            F +  D D S+I+MAFSK+K EDRKVW+ N+        E G   +++  +    I++KD
Sbjct: 692  FRYAGDEDDSSIDMAFSKRKIEDRKVWLTNWMAEKRDRREQGLTEEYLYDKDTRSISFKD 751

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            FVNKEL+LFS AD +RSIPS+VDGLKPGQRK+LF  FK+   KE+KV Q  G V E SAY
Sbjct: 752  FVNKELVLFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAY 811

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQSL STI+ +AQD+VGSNNINLL P GQFGTR  GGKD AS RYI+T+LNP+T+ L
Sbjct: 812  HHGEQSLMSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKAL 871

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD +L +L E+ + IEP WY PIIP VLVNG+EGIGT WS+ +PNYNPR+I+ N+R
Sbjct: 872  FPSVDDNVLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKVPNYNPREIVDNIR 931

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            RL+  E   PM PW++ F+G IE+   +  +  +G +  + + +  ITELPIR WTQ+YK
Sbjct: 932  RLIRGEDPKPMVPWFKNFRGTIEQ-LDDQRFACSGEIAILRDDTLEITELPIRVWTQNYK 990

Query: 536  Q-FLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
            +  LE + +GS + +  LI+DF++   D  V   I+M  +K+     EGL K FKL T I
Sbjct: 991  ESVLEPLLEGS-DKQPALIQDFKEYHTDTTVRFVIKMSAQKLRDAEMEGLHKVFKLQTAI 1049

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            +TS+M LFDA G ++K+ N E+I +EFF  R   Y  RK +           L N+ RFI
Sbjct: 1050 NTSSMVLFDAAGCLRKFRNVEEICKEFFETRKKKYIERKAFQEGMLRAQSERLSNQARFI 1109

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-----KSAEPQVAGAXXXXXXXXXXX 709
            L  + GEI++ N++K  ++ +L +KGF P P K      +  E ++ G            
Sbjct: 1110 LAKIKGEILIENKRKVAIVEQLVKKGFDPDPVKKWKELQRRKELEMTGEVEVDEEELEQD 1169

Query: 710  XXXXXXXXXXXXKR------GDYEYLLSMSIGTLTLESVQXXXXXXXXXXXXXXXXXATP 763
                        K+       DY+YL+ M+I  L+ E                       
Sbjct: 1170 EEEQTNVPSSPLKKDLEKKLSDYDYLVGMAILKLSEEEKDKLLRESEAKMSELKTLEDMT 1229

Query: 764  SKSMWMXXXXXXXXXXXXQDGKEAEDEKKRISQASKR 800
               +W             Q+ KE  D   +I  A+KR
Sbjct: 1230 WADLWNADLDNFLVELQKQEAKEKGDGALQIKTAAKR 1266


>G7NY94_MACFA (tr|G7NY94) DNA topoisomerase 2 (Fragment) OS=Macaca fascicularis
            GN=EGM_11149 PE=3 SV=1
          Length = 1603

 Score =  708 bits (1827), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/751 (50%), Positives = 502/751 (66%), Gaps = 31/751 (4%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 399  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 458

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 459  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 518

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 519  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 577

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 578  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 635

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 636  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 695

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 696  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 755

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 756  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 815

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 816  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 875

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 876  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 934

Query: 536  -QFLESITDGSPNVKDP-LIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTT 593
             Q LE + +G+   K P LI D+++   D  V   ++M  EK+A     GL K FKL TT
Sbjct: 935  EQVLEPMLNGTD--KTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTT 992

Query: 594  ISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRF 653
            ++ ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RF
Sbjct: 993  LTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF 1052

Query: 654  ILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXX 712
            IL  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                
Sbjct: 1053 ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDS 1112

Query: 713  XXXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                        D+ Y+L+MS+ +LT E V+
Sbjct: 1113 GTPSGP------DFNYILNMSLWSLTKEKVE 1137


>F1KQV5_ASCSU (tr|F1KQV5) DNA topoisomerase 2 OS=Ascaris suum PE=2 SV=1
          Length = 1586

 Score =  707 bits (1826), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 361/693 (52%), Positives = 482/693 (69%), Gaps = 22/693 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            +V   GI++ +++W  FKQ + L KK    +T +L+G+ KLEDANDAG +NS  CTLILT
Sbjct: 455  SVMKCGIVEAVMAWVRFKQQETLDKKCSSKRTSKLKGVPKLEDANDAGTKNSSLCTLILT 514

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL VVGRD YGVFPLRGK+LNVRE ++KQIM+N EI  + KI+GLQ   
Sbjct: 515  EGDSAKSLAVSGLGVVGRDRYGVFPLRGKMLNVREGNHKQIMENAEINALIKIIGLQYRL 574

Query: 131  EYS---NVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
            +Y    ++K+LRYG +M+MADQD DGSHIKGL+INFIH  WP+L++  +F+ EF TPI++
Sbjct: 575  KYDKDDDMKTLRYGKVMVMADQDQDGSHIKGLVINFIHYNWPALIRR-NFVEEFITPIVK 633

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A      + SF+S+PEY  WR N   N   ++IKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 634  ATKGK-EEYSFFSLPEYNEWRNNT-ENWKSYRIKYYKGLGTSTSKEAKEYFTDMARHRIR 691

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNF--------EPGNYRDHVASR----INYKD 295
            F +  D D S+I+MAFSK+K EDRKVW+ N+        E G   +++  +    I++KD
Sbjct: 692  FRYAGDEDDSSIDMAFSKRKIEDRKVWLTNWMAEKRDRREQGLTEEYLYDKDTRSISFKD 751

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            FVNKEL+LFS AD +RSIPS+VDGLKPGQRK+LF  FK+   KE+KV Q  G V E SAY
Sbjct: 752  FVNKELVLFSNADNERSIPSLVDGLKPGQRKVLFTCFKRADKKEVKVAQLAGAVGEMSAY 811

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQSL STI+ +AQD+VGSNNINLL P GQFGTR  GGKD AS RYI+T+LNP+T+ L
Sbjct: 812  HHGEQSLMSTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLNPVTKAL 871

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD +L +L E+ + IEP WY PIIP VLVNG+EGIGT WS+ +PNYNPR+I+ N+R
Sbjct: 872  FPSVDDNVLRFLFEENQRIEPEWYCPIIPTVLVNGAEGIGTAWSTKVPNYNPREIVDNIR 931

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            RL+  E   PM PW++ F+G IE+   +  +  +G +  + + +  ITELPIR WTQ+YK
Sbjct: 932  RLIRGEDPKPMVPWFKNFRGTIEQ-LDDQRFACSGEIAILRDDTLEITELPIRVWTQNYK 990

Query: 536  Q-FLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
            +  LE + +GS + +  LI+DF++   D  V   I+M  +K+     EGL K FKL T I
Sbjct: 991  ESVLEPLLEGS-DKQPALIQDFKEYHTDTTVRFVIKMSAQKLRDAEMEGLHKVFKLQTAI 1049

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            +TS+M LFDA G ++K+ N E+I +EFF  R   Y  RK +           L N+ RFI
Sbjct: 1050 NTSSMVLFDAAGCLRKFRNVEEICKEFFETRKKKYIERKAFQEGMLRAQSERLSNQARFI 1109

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKK 687
            L  + GEI++ N++K  ++ +L +KGF P P K
Sbjct: 1110 LAKIKGEILIENKRKVAIVEQLVKKGFDPDPVK 1142


>L7MAX8_9ACAR (tr|L7MAX8) DNA topoisomerase 2 (Fragment) OS=Rhipicephalus
            pulchellus PE=2 SV=1
          Length = 1662

 Score =  707 bits (1825), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 361/720 (50%), Positives = 491/720 (68%), Gaps = 51/720 (7%)

Query: 13   VANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTE 71
            V   G+++ ++SW +FK  K L +K    K  +L+GI KLEDANDAG RNS  CTLILTE
Sbjct: 509  VLKCGVVEAVMSWVNFKAQKQLGQKCSAKKHSKLKGIPKLEDANDAGTRNSVDCTLILTE 568

Query: 72   GDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKE 131
            GDSAK+LA++GL+VVGRD +GVFPL+GK+LNVREA++KQI++N EI N+ KI+GLQ  K+
Sbjct: 569  GDSAKSLAVSGLAVVGRDKFGVFPLKGKILNVREATHKQILENAEINNVIKIMGLQYKKK 628

Query: 132  YSNV---KSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRA 188
            Y +V   K+LRYG LMIM DQD DGSHIKGLLINFIH  WPSLLK+P F+ EF TPI++A
Sbjct: 629  YESVEDLKTLRYGRLMIMTDQDQDGSHIKGLLINFIHHNWPSLLKLP-FLEEFITPIVKA 687

Query: 189  FHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDF 248
                 T+LSFYS+PE+E W+    ++   WK+KYYKGLGTST +E +EYF D+ +HR  F
Sbjct: 688  TKGK-TELSFYSLPEFEEWKAAT-DDWQRWKVKYYKGLGTSTAKEAKEYFIDMARHRIKF 745

Query: 249  VWEDDYDGSAIEMAFSKKKAEDRKVWIRN-FEPGNYRDHVA-----------SRINYKDF 296
             ++   D  AIE+AFSKK  E RK W+RN  E    R  +              I Y+DF
Sbjct: 746  KYQGGEDDRAIELAFSKKMIEQRKEWLRNGMEERKQRRELGLPEVYLYGKDTRNITYEDF 805

Query: 297  VNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYH 356
            VNKELILFS  D +RSIPS+VDGLKPGQRK+L+  FK+   +EIKV Q  G V+EHSAYH
Sbjct: 806  VNKELILFSNMDNERSIPSLVDGLKPGQRKVLYTCFKRNDKREIKVAQLAGSVAEHSAYH 865

Query: 357  HGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLF 416
            HGE SL STII +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+P+ R + 
Sbjct: 866  HGEVSLMSTIINLAQNFVGSNNINLLQPIGQFGTRLQGGKDAASPRYIFTMLSPLARLIM 925

Query: 417  HENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRR 476
              +DD +L+YL +D + IEP +YIPI+P+VLVNG+EGIGTGWS+ IPNYNPR+I+AN+R+
Sbjct: 926  PASDDPILDYLFDDNQRIEPEYYIPILPMVLVNGAEGIGTGWSTKIPNYNPREIVANLRK 985

Query: 477  LLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ 536
            +LN E   PM PW++ F+G +++   +  ++++G V  +   +  ITELP+R WTQ YK+
Sbjct: 986  MLNGEETKPMKPWFKNFRGSVDQVEPQ-RFLISGEVAILSSTTIEITELPVRTWTQAYKE 1044

Query: 537  -FLESITDGS----PNVKD--------------------------PLIEDFRQNGDDAMV 565
              LE++  GS    P + D                          PLI D+++   D  V
Sbjct: 1045 SVLEAMLHGSEKVPPLITDYKEYHTDTTVRFVVTMTEXHGSEKVPPLITDYKEYHTDTTV 1104

Query: 566  DIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLR 625
               + M  EK++    EGL K FKL T+++TS+M LFD++G +  +  PE+IL++F+  R
Sbjct: 1105 RFVVTMTEEKLSKARDEGLHKVFKLQTSLTTSSMVLFDSKGVLTTFRTPEEILKDFYETR 1164

Query: 626  LDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMP 685
            L+ Y++RK Y++         L+N+ RFIL  +   I + NR++ ++++ L+++G+ P P
Sbjct: 1165 LEGYKKRKAYMMGLLSAEAKKLENQARFILEKIDNLIKIENRRRKEMILTLRERGYDPDP 1224


>Q76C44_9EURO (tr|Q76C44) DNA topoisomerase 2 (Fragment) OS=Arthroderma racemosum
            GN=top2 PE=3 SV=1
          Length = 1089

 Score =  707 bits (1825), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 350/683 (51%), Positives = 473/683 (69%), Gaps = 13/683 (1%)

Query: 10   MFAVANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLIL 69
            M  V  + +++ +L +A+ K  + LKKTDG +  R+    KL DAN AG +    CTLIL
Sbjct: 369  MKKVMKTRVMEDILHFAEKKADQILKKTDGNRRSRMNN-PKLTDANKAGTKEGHHCTLIL 427

Query: 70   TEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQN 129
            TEGDSAK LAMAG +VVG D +GVFPLRGKLLNVR+AS  QI  N EIQNIK  +GLQ  
Sbjct: 428  TEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNSEIQNIKNFIGLQHK 487

Query: 130  KEYSNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAF 189
            KEY++ + LRYGHLMIM DQDHDGSHIKGLLIN++   +P+LLK+P F++EF TPI++ +
Sbjct: 488  KEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVW 547

Query: 190  HSN----GTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHR 245
              +        SF+++PEYE W+E   N+   W+ KYYKGLGTS+ ++ + YF+DL +H 
Sbjct: 548  KGDPKNPTHSKSFFTLPEYEEWKEAHTNDKK-WQKKYYKGLGTSSTEDAQIYFQDLDRHL 606

Query: 246  KDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFS 305
            K F    D +   IE+AFSKKKA++RK W+R F+PG Y DH   +I Y DF+NKELILFS
Sbjct: 607  KQFHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFS 666

Query: 306  RADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLAST 365
             AD  RSIPSVVDGLKPGQRK+L+  FK+ + K+IKV +  GYVS  +AY HG+ SL +T
Sbjct: 667  MADNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHAT 726

Query: 366  IIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLE 425
            I+G+AQ FVGSNNIN L+P+G FG+R  GG D AS+RYIYT L+P  R LFH+ D+ LL 
Sbjct: 727  IVGLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLV 786

Query: 426  YLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVP 485
               +DG+ IEP  Y+P++PLVL+NG++GIGTGWS+ IPNYNP +++ N++RL+  + +VP
Sbjct: 787  NNIDDGKVIEPETYVPVVPLVLINGADGIGTGWSTSIPNYNPEEVVDNLKRLMAGDELVP 846

Query: 486  MDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGS 545
            M PW+RGFKG +  S     Y  +G +++  +    ITELPIR WTQD+K  LE I    
Sbjct: 847  MKPWFRGFKGEVTGSGDR--YKFSGIIKQTGDNEVEITELPIRTWTQDFKDKLEDIIKAE 904

Query: 546  PNVKDP-LIEDFRQNGDDAMVDIEIRMKLEK-IAMIMQEGLLKKFKLTTTISTSNMHLFD 603
               K P  I+D+R       V   I+  ++  +   +++GL ++FKL   I+TSNM  FD
Sbjct: 905  ---KVPSFIKDYRDYNTHTNVHFIIQSGVKNTVKKAVEDGLEERFKLVKPIATSNMVAFD 961

Query: 604  AEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIV 663
            AEG+I +YE PE IL  F+ +R+  YE+RKQ++L   +  L  L N+ RF+  ++ G++V
Sbjct: 962  AEGRITRYETPEDILRAFYAVRIKLYEKRKQHLLSQLQSQLEKLTNQARFVQMIIDGKLV 1021

Query: 664  VSNRKKADLLMELQQKGFTPMPK 686
            +S +KKA L+ ELQ+K F P PK
Sbjct: 1022 ISKKKKAVLIQELQEKAFKPFPK 1044


>H2UY96_TAKRU (tr|H2UY96) DNA topoisomerase 2 (Fragment) OS=Takifugu rubripes
            GN=LOC101075432 PE=3 SV=1
          Length = 1552

 Score =  707 bits (1825), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 361/690 (52%), Positives = 474/690 (68%), Gaps = 22/690 (3%)

Query: 16   SGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
             GI++++++W  FK    L KK    K  +++G+ KL+DANDAGG+NS  CTLILTEGDS
Sbjct: 407  CGIVESIMNWVKFKAQTQLNKKCSAVKHTKIKGVPKLDDANDAGGKNSIGCTLILTEGDS 466

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AK LA++GL VVGRD YGVFPLRGK+LNVREAS KQIM+N EI NI KILGLQ  K YS+
Sbjct: 467  AKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASLKQIMENAEINNIIKILGLQYKKNYSD 526

Query: 135  ---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
               +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLL+  +F+ EF TPII+A H 
Sbjct: 527  PESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHK 585

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              ++LSFYS+PE+ +W+E+  N+ + WKIKYYKGLGTST QE +EYF D+ +HR  F + 
Sbjct: 586  K-SQLSFYSIPEFNAWKESQANHKS-WKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYA 643

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPG--NYRDH----------VASRINYKDFVNK 299
               D  AI +AFSKKK E+RK W+ NF       R+H              ++Y DFVNK
Sbjct: 644  GPEDDEAITLAFSKKKVEERKEWLTNFMTNRRQRREHNLPEDYLYGQTTKYLSYNDFVNK 703

Query: 300  ELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGE 359
            EL+LFS +D +RSIP +VDG KPGQRK+LFC FK+   +E+KV Q  G V+E SAYHHGE
Sbjct: 704  ELVLFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGE 763

Query: 360  QSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHEN 419
             SL  TI+G+AQ+FVGSNN+N+L+P GQFGTR  GGKD AS RYI+T L+ +TR +F   
Sbjct: 764  VSLMMTIVGLAQNFVGSNNLNMLQPLGQFGTRLHGGKDSASPRYIFTMLSTLTRLVFPPV 823

Query: 420  DDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLN 479
            DD LL+Y  +D + +EP WYIPIIP+VLVNG+EGIGTGW+S IPNY+ R+I+ N+ R+LN
Sbjct: 824  DDNLLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDVREIVNNIHRMLN 883

Query: 480  DETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ-FL 538
             +  +PM P Y+GFKG IE       Y+ +G V  ID  +  I+ELP++ WTQ YK+  L
Sbjct: 884  GDEPLPMLPSYKGFKGTIE-HVMNNQYMNSGEVAIIDSTTIEISELPVKSWTQTYKENVL 942

Query: 539  ESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSN 598
            E + +G+  V  PLI DF++   D  V   ++M  EK+      G  K FKL   ++ ++
Sbjct: 943  EPMLNGTEKVP-PLITDFKEYHTDTTVRFVVKMSEEKLREAEAAGFHKVFKLQNPLTCNS 1001

Query: 599  MHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVV 658
            M LFD  G +KKYE+ + IL++FF LR+ YY  RK +++         L N+ RFIL  +
Sbjct: 1002 MVLFDHAGSLKKYESVQDILKDFFELRMKYYVLRKDWLVGMLGAESAKLTNQARFILEKI 1061

Query: 659  SGEIVVSNRKKADLLMELQQKGFTPMPKKG 688
             G +V+ N+ K +L+  LQQ G+   P K 
Sbjct: 1062 QGTLVIENKPKKELIRMLQQMGYDSDPVKA 1091


>F7FGH6_ORNAN (tr|F7FGH6) DNA topoisomerase 2 OS=Ornithorhynchus anatinus GN=TOP2B
            PE=3 SV=2
          Length = 1584

 Score =  707 bits (1824), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 372/750 (49%), Positives = 500/750 (66%), Gaps = 29/750 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 386  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 445

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 446  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 505

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 506  SYEDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 564

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++ N+   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 565  A-SKNKQELSFYSIPEFDEWKKHMENHK-AWKIKYYKGLGTSTAKEAKEYFADMERHRIL 622

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 623  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 682

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF   K+   +E+KV Q  G V+E SAY
Sbjct: 683  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCCKRNDRREVKVAQLAGSVAEMSAY 742

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+ + R L
Sbjct: 743  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 802

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 803  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 862

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ F+G I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 863  RMLDGLDPHPMLPNYKNFRGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 921

Query: 536  -QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
             Q LE + +G+      LI D+++   D  V   ++M  EK+A     GL K FKL TT+
Sbjct: 922  EQVLEPMLNGTDKTP-ALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTL 980

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            + ++M LFD  G +KKYE  + IL+EFF LRL+YY  RK++++         L+N+ RFI
Sbjct: 981  TCNSMVLFDHMGCLKKYETVQDILKEFFDLRLNYYSLRKEWLMGMLGAESTKLNNQARFI 1040

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQVAGAXXXXXXXXXXXXXXX 713
            L  + G+I + NR K DL+  L Q+G+   P K  K A+ + A                 
Sbjct: 1041 LEKIQGKITIENRSKRDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSG 1100

Query: 714  XXXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                       D+ Y+L+MS+  LT E V+
Sbjct: 1101 TTTGP------DFNYILNMSLWCLTKEKVE 1124


>H2UY95_TAKRU (tr|H2UY95) DNA topoisomerase 2 (Fragment) OS=Takifugu rubripes
            GN=LOC101075432 PE=3 SV=1
          Length = 1581

 Score =  707 bits (1824), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 361/690 (52%), Positives = 474/690 (68%), Gaps = 22/690 (3%)

Query: 16   SGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEGDS 74
             GI++++++W  FK    L KK    K  +++G+ KL+DANDAGG+NS  CTLILTEGDS
Sbjct: 402  CGIVESIMNWVKFKAQTQLNKKCSAVKHTKIKGVPKLDDANDAGGKNSIGCTLILTEGDS 461

Query: 75   AKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEYSN 134
            AK LA++GL VVGRD YGVFPLRGK+LNVREAS KQIM+N EI NI KILGLQ  K YS+
Sbjct: 462  AKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASLKQIMENAEINNIIKILGLQYKKNYSD 521

Query: 135  ---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHS 191
               +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLL+  +F+ EF TPII+A H 
Sbjct: 522  PESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFIEEFITPIIKASHK 580

Query: 192  NGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVWE 251
              ++LSFYS+PE+ +W+E+  N+ + WKIKYYKGLGTST QE +EYF D+ +HR  F + 
Sbjct: 581  K-SQLSFYSIPEFNAWKESQANHKS-WKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYA 638

Query: 252  DDYDGSAIEMAFSKKKAEDRKVWIRNFEPG--NYRDH----------VASRINYKDFVNK 299
               D  AI +AFSKKK E+RK W+ NF       R+H              ++Y DFVNK
Sbjct: 639  GPEDDEAITLAFSKKKVEERKEWLTNFMTNRRQRREHNLPEDYLYGQTTKYLSYNDFVNK 698

Query: 300  ELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGE 359
            EL+LFS +D +RSIP +VDG KPGQRK+LFC FK+   +E+KV Q  G V+E SAYHHGE
Sbjct: 699  ELVLFSNSDNERSIPCLVDGFKPGQRKVLFCCFKRNDKREVKVAQLAGSVAEMSAYHHGE 758

Query: 360  QSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHEN 419
             SL  TI+G+AQ+FVGSNN+N+L+P GQFGTR  GGKD AS RYI+T L+ +TR +F   
Sbjct: 759  VSLMMTIVGLAQNFVGSNNLNMLQPLGQFGTRLHGGKDSASPRYIFTMLSTLTRLVFPPV 818

Query: 420  DDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLN 479
            DD LL+Y  +D + +EP WYIPIIP+VLVNG+EGIGTGW+S IPNY+ R+I+ N+ R+LN
Sbjct: 819  DDNLLKYNYDDNQRVEPEWYIPIIPMVLVNGAEGIGTGWASKIPNYDVREIVNNIHRMLN 878

Query: 480  DETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQ-FL 538
             +  +PM P Y+GFKG IE       Y+ +G V  ID  +  I+ELP++ WTQ YK+  L
Sbjct: 879  GDEPLPMLPSYKGFKGTIE-HVMNNQYMNSGEVAIIDSTTIEISELPVKSWTQTYKENVL 937

Query: 539  ESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSN 598
            E + +G+  V  PLI DF++   D  V   ++M  EK+      G  K FKL   ++ ++
Sbjct: 938  EPMLNGTEKVP-PLITDFKEYHTDTTVRFVVKMSEEKLREAEAAGFHKVFKLQNPLTCNS 996

Query: 599  MHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVV 658
            M LFD  G +KKYE+ + IL++FF LR+ YY  RK +++         L N+ RFIL  +
Sbjct: 997  MVLFDHAGSLKKYESVQDILKDFFELRMKYYVLRKDWLVGMLGAESAKLTNQARFILEKI 1056

Query: 659  SGEIVVSNRKKADLLMELQQKGFTPMPKKG 688
             G +V+ N+ K +L+  LQQ G+   P K 
Sbjct: 1057 QGTLVIENKPKKELIRMLQQMGYDSDPVKA 1086


>G3I5N5_CRIGR (tr|G3I5N5) DNA topoisomerase 2 OS=Cricetulus griseus GN=I79_018788
            PE=3 SV=1
          Length = 1526

 Score =  706 bits (1823), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 365/702 (51%), Positives = 484/702 (68%), Gaps = 23/702 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A    GI++++L+W  FK    L KK    K  R++GI KL+DANDAG RNS +CTLILT
Sbjct: 400  AAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDANDAGSRNSTECTLILT 459

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK LA++GL VVGRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 460  EGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 519

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLL+   F+ EF TPI++
Sbjct: 520  NYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLEEFITPIVK 578

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
                N  +L+FYS+PE+E W+ +  N+   WK+KYYKGLGTST +E +EYF D+ +HR  
Sbjct: 579  V-SKNKQELAFYSLPEFEEWKSSTPNHKK-WKVKYYKGLGTSTSKEAKEYFADMKRHRIQ 636

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNY-RDHVASRINYKD 295
            F +    D +AI +AFSKK+ +DRK W+ +F            P +Y      + + Y D
Sbjct: 637  FKYSGPEDDAAISLAFSKKQVDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYND 696

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDGLKPGQRK+LF  FK+   +E+KV Q  G V+E S+Y
Sbjct: 697  FINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSY 756

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGE SL  TII +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI+T L+P+TR L
Sbjct: 757  HHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLTRLL 816

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD  L++L +D + +EP WYIPIIP+VL+NG+EGIGTGWS  IPN++ R+++ N+R
Sbjct: 817  FPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIR 876

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            RLL+ E  +PM P Y+ FKG IE+ A    Y++NG V  ++  +  I+ELPIR WTQ YK
Sbjct: 877  RLLDGEEPLPMLPSYKNFKGTIEELA-SNQYVINGEVAILNSTTIEISELPIRTWTQTYK 935

Query: 536  -QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
             Q LE + +G+     PLI D+R+   D  V   I+M  EK+A   + GL K FKL T++
Sbjct: 936  EQVLEPMLNGTEKTP-PLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSL 994

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            + ++M LFD  G +KKY+    IL++FF LRL YY  RK+++L         L+N+ RFI
Sbjct: 995  TCNSMVLFDHVGCLKKYDTVLDILKDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFI 1054

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQV 695
            L  + G+I++ N+ K +L+  L Q+G+   P K  K A+ +V
Sbjct: 1055 LEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKV 1096


>L8IH03_BOSMU (tr|L8IH03) DNA topoisomerase 2 (Fragment) OS=Bos grunniens mutus
            GN=M91_05302 PE=3 SV=1
          Length = 1600

 Score =  706 bits (1823), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/713 (50%), Positives = 489/713 (68%), Gaps = 24/713 (3%)

Query: 1    MVFYTYMLQMFAVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGG 59
            M  ++  LQ  A+   GI++++L+W  FK    L KK    K  R++GI KL+DANDAGG
Sbjct: 461  MSCFSQRLQPTAIG-CGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDANDAGG 519

Query: 60   RNSDKCTLILTEGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQN 119
            RNS +CTLILTEGDSAK LA++GL VVGRD YGVFPLRGK+LNVREAS+KQIM+N EI N
Sbjct: 520  RNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINN 579

Query: 120  IKKILGLQQNKEYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPS 176
            I KI+GLQ  K Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLL+   
Sbjct: 580  IIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HR 638

Query: 177  FMVEFTTPIIRAFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGRE 236
            F+ EF TPI++    N  +++FYS+PE+E W+ +  N+   WK+KYYKGLGTST +E +E
Sbjct: 639  FLEEFITPIVKV-SKNKQEMAFYSLPEFEEWKSSTPNHKK-WKVKYYKGLGTSTSKEAKE 696

Query: 237  YFRDLGKHRKDFVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNY-R 284
            YF D+ +HR  F +    D +AI +AFSKK+ +DRK W+ +F            P +Y  
Sbjct: 697  YFADMKRHRIQFKYSGPEDDAAISLAFSKKQTDDRKEWLTHFMEDRRQRKLLGLPDDYLY 756

Query: 285  DHVASRINYKDFVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQ 344
                + + Y DF+NKELILFS +D +RSIPS+VDGLKPGQRK+LF  FK+   +E+KV Q
Sbjct: 757  GQATTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQ 816

Query: 345  FIGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYI 404
              G V+E S+YHHGE SL  TII +AQ+FVGSNN+NLL+P GQFGTR  GGKD AS RYI
Sbjct: 817  LAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYI 876

Query: 405  YTELNPITRCLFHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPN 464
            +T L+P+ R LF   DD  L++L +D + +EP WYIPIIP+VL+NG+EGIGTGWS  IPN
Sbjct: 877  FTMLSPLARLLFPAKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 936

Query: 465  YNPRDIIANVRRLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITE 524
            ++ R+++ N+RRL++ E  +PM P Y+ FKG +E+ A    Y+++G V  ++  +  I+E
Sbjct: 937  FDVREVVNNIRRLMDGEEPLPMLPSYKNFKGTVEELA-PNQYVISGEVAILNSTTIEISE 995

Query: 525  LPIRKWTQDYK-QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEG 583
            LPIR WTQ YK Q LE + +G+     PLI D+R+   D  V   ++M  EK+A   + G
Sbjct: 996  LPIRTWTQTYKEQVLEPMLNGTEKTP-PLITDYREYHTDTTVKFVVKMTEEKLAEAERAG 1054

Query: 584  LLKKFKLTTTISTSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERL 643
            L K FKL T+++ ++M LFD  G +KKY+    IL +FF LRL YY  RK+++L      
Sbjct: 1055 LHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAE 1114

Query: 644  LLVLDNKVRFILGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKG-KSAEPQV 695
               L+N+ RFIL  + G+I++ N+ K +L+  L Q+G+   P K  K A+ +V
Sbjct: 1115 SAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKV 1167


>K9IVG7_DESRO (tr|K9IVG7) DNA topoisomerase 2 (Fragment) OS=Desmodus rotundus PE=2
            SV=1
          Length = 1639

 Score =  706 bits (1823), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 373/749 (49%), Positives = 498/749 (66%), Gaps = 27/749 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 420  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 479

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 480  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 539

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 540  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 598

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 599  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 656

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 657  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 716

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 717  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 776

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+P+ R L
Sbjct: 777  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARRL 836

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 837  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 896

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 897  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 955

Query: 536  -QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
             Q LE + +G+      LI D+++   D  V   ++M  EK+A     GL K FKL TT+
Sbjct: 956  EQVLEPMLNGTDKTP-ALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTL 1014

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            + ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RFI
Sbjct: 1015 TCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFI 1074

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXX 714
            L  + G+I + NR K DL+  L Q+G+   P K      + A                  
Sbjct: 1075 LEKIQGKIAIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEESQNQHDDSSSDSG 1134

Query: 715  XXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                      D+ Y+L+MS+ +LT E V+
Sbjct: 1135 TPSGP-----DFNYILNMSLWSLTKEKVE 1158


>K9IV03_DESRO (tr|K9IV03) DNA topoisomerase 2 (Fragment) OS=Desmodus rotundus PE=2
            SV=1
          Length = 1603

 Score =  706 bits (1822), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 373/749 (49%), Positives = 498/749 (66%), Gaps = 27/749 (3%)

Query: 12   AVANSGILDTLLSWADFKQSKDL-KKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILT 70
            A +N GI++++L+W  FK    L KK    K  +++GI KL+DANDAGG++S +CTLILT
Sbjct: 399  AASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILT 458

Query: 71   EGDSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNK 130
            EGDSAK+LA++GL V+GRD YGVFPLRGK+LNVREAS+KQIM+N EI NI KI+GLQ  K
Sbjct: 459  EGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKK 518

Query: 131  EYSN---VKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIR 187
             Y +   +K+LRYG +MIM DQD DGSHIKGLLINFIH  WPSLLK   F+ EF TPI++
Sbjct: 519  SYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVK 577

Query: 188  AFHSNGTKLSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKD 247
            A   N  +LSFYS+PE++ W++++  N   WKIKYYKGLGTST +E +EYF D+ +HR  
Sbjct: 578  A-SKNKQELSFYSIPEFDEWKKHI-ENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRIL 635

Query: 248  FVWEDDYDGSAIEMAFSKKKAEDRKVWIRNFE-----------PGNYRDHVASR-INYKD 295
            F +    D +AI +AFSKKK +DRK W+ NF            P  +    A++ + Y D
Sbjct: 636  FRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYND 695

Query: 296  FVNKELILFSRADLQRSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAY 355
            F+NKELILFS +D +RSIPS+VDG KPGQRK+LF  FK+   +E+KV Q  G V+E SAY
Sbjct: 696  FINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY 755

Query: 356  HHGEQSLASTIIGMAQDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCL 415
            HHGEQ+L  TI+ +AQ+FVGSNNINLL+P GQFGTR  GGKD AS RYI+T L+P+ R L
Sbjct: 756  HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSPLARRL 815

Query: 416  FHENDDKLLEYLNEDGRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVR 475
            F   DD LL++L +D + +EP WYIPIIP+VL+NG+EGIGTGW+  +PNY+ R+I+ NVR
Sbjct: 816  FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVR 875

Query: 476  RLLNDETMVPMDPWYRGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYK 535
            R+L+     PM P Y+ FKG I++   +  Y V+G +  +D  +  ITELP+R WTQ YK
Sbjct: 876  RMLDGLDPHPMLPNYKNFKGTIQELG-QNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK 934

Query: 536  -QFLESITDGSPNVKDPLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTI 594
             Q LE + +G+      LI D+++   D  V   ++M  EK+A     GL K FKL TT+
Sbjct: 935  EQVLEPMLNGTDKTP-ALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTL 993

Query: 595  STSNMHLFDAEGKIKKYENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFI 654
            + ++M LFD  G +KKYE  + IL+EFF LRL YY  RK++++         L+N+ RFI
Sbjct: 994  TCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFI 1053

Query: 655  LGVVSGEIVVSNRKKADLLMELQQKGFTPMPKKGKSAEPQVAGAXXXXXXXXXXXXXXXX 714
            L  + G+I + NR K DL+  L Q+G+   P K      + A                  
Sbjct: 1054 LEKIQGKIAIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEESQNQHDDSSSDSG 1113

Query: 715  XXXXXXXKRGDYEYLLSMSIGTLTLESVQ 743
                      D+ Y+L+MS+ +LT E V+
Sbjct: 1114 TPSGP-----DFNYILNMSLWSLTKEKVE 1137


>I2H4V9_TETBL (tr|I2H4V9) DNA topoisomerase 2 OS=Tetrapisispora blattae (strain
            ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL
            Y-10934 / UCD 77-7) GN=TBLA0E03570 PE=3 SV=1
          Length = 1368

 Score =  706 bits (1822), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 356/679 (52%), Positives = 468/679 (68%), Gaps = 6/679 (0%)

Query: 13   VANSGILDTLLSWADFKQSKDLKKTDGTKTQRLRGIVKLEDANDAGGRNSDKCTLILTEG 72
            +  + +   +   AD   +  LKK+DG++  R+    KLEDAN AG +   KCTLILTEG
Sbjct: 388  IMKTDLATKIFEIADENANNALKKSDGSRKSRITEYPKLEDANKAGTKEGHKCTLILTEG 447

Query: 73   DSAKALAMAGLSVVGRDHYGVFPLRGKLLNVREASNKQIMDNEEIQNIKKILGLQQNKEY 132
            DSA +LA+AGL+VVGRD+YG +PLRGK+LNVREAS  QI+ N EIQ IKKI+GLQ  K Y
Sbjct: 448  DSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKRY 507

Query: 133  SNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFTTPIIRAFHSN 192
             +  SLRYGHLMIM DQDHDGSHIKGL+INF+ S +P LL +P F+VEF TPII+   + 
Sbjct: 508  EDTSSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIPGFLVEFITPIIKVTITK 567

Query: 193  GTK--LSFYSMPEYESWRENLGNNATGWKIKYYKGLGTSTPQEGREYFRDLGKHRKDFVW 250
             ++  + FY+MP+YE WRE   +  T WK KYYKGLGTST QE REYF DL KH K F  
Sbjct: 568  PSRQTIVFYNMPDYEKWREEESHQYT-WKQKYYKGLGTSTGQEMREYFSDLDKHLKQFHA 626

Query: 251  EDDYDGSAIEMAFSKKKAEDRKVWIRNFEPGNYRDHVASRINYKDFVNKELILFSRADLQ 310
             +  D   I++AFSKKKA+DRK W+R  EPG   D     I   DF+NKELILFS AD  
Sbjct: 627  LEGNDKDLIDLAFSKKKADDRKEWLRQHEPGTVLDPTIKEIPISDFINKELILFSLADNI 686

Query: 311  RSIPSVVDGLKPGQRKILFCSFKKKLFKEIKVGQFIGYVSEHSAYHHGEQSLASTIIGMA 370
            RSIP+V+DG KPGQRK++F  FK+ L  EIKV Q   YV E +AYHHGEQSLA TIIGMA
Sbjct: 687  RSIPNVLDGFKPGQRKVMFGCFKRNLRSEIKVAQLAPYVGECTAYHHGEQSLAQTIIGMA 746

Query: 371  QDFVGSNNINLLKPNGQFGTRNLGGKDHASSRYIYTELNPITRCLFHENDDKLLEYLNED 430
            Q+FVG+NNI LL PNG FGTR  GGKD A++RYIYTELN +TR +F+ NDD L  Y+ ED
Sbjct: 747  QNFVGTNNIYLLIPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFNPNDDPLYNYIQED 806

Query: 431  GRSIEPSWYIPIIPLVLVNGSEGIGTGWSSYIPNYNPRDIIANVRRLLNDETMVPMDPWY 490
              ++EP WY+P++P +LVNGSEGIGTGWS+ IP++NP DII N++ L+N+E M  M PW+
Sbjct: 807  ETTVEPQWYLPVLPTLLVNGSEGIGTGWSTNIPSFNPLDIIKNIKHLMNNEEMEEMHPWF 866

Query: 491  RGFKGIIEKSAKEGGYIVNGTVEEIDEQSFRITELPIRKWTQDYKQFLESITDGSPNVKD 550
            RG+ G IEK   +  Y + G +E+I   +  ITELP + WT   K++L     G+   K 
Sbjct: 867  RGWTGTIEKIGYQ-RYRMYGRIEQIGPNTLEITELPAKVWTSTIKEYLLQGLSGTEKTKA 925

Query: 551  PLIEDFRQNGDDAMVDIEIRMKLEKIAMIMQEGLLKKFKLTTTISTSNMHLFDAEGKIKK 610
             + +   Q+G+   +   I++  E++    + G  ++FKL + IS +NM  FD +G+IKK
Sbjct: 926  WIKDMEEQHGN--FIKFIIKLTPEEMQKTRKIGFYERFKLISPISLNNMVAFDPQGRIKK 983

Query: 611  YENPEQILEEFFPLRLDYYERRKQYILENFERLLLVLDNKVRFILGVVSGEIVVSNRKKA 670
            YENP++IL+EF+ +RL+YY++RK Y+ E  +  +  L  +V+FI  ++  E+VVSN  K 
Sbjct: 984  YENPQEILKEFYYVRLEYYQKRKDYMCEKLQWDVEKLSFQVKFIKMIIEKELVVSNIPKK 1043

Query: 671  DLLMELQQKGFTPMPKKGK 689
             ++ EL+  GF  + K GK
Sbjct: 1044 QIIKELETLGFPRINKDGK 1062