Miyakogusa Predicted Gene

Lj1g3v3381400.2
Show Alignment: 

BLASTP 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= Lj1g3v3381400.2 tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate
reductase-thymidylate synthase OS=Glycine max GN=G,86.21,0,seg,NULL;
Thymidylate synthase/dCMP hydroxymethylase,Thymidylate synthase/dCMP
hydroxymethylase doma,CUFF.30578.2
         (524 letters)

Database: trembl 
           41,451,118 sequences; 13,208,986,710 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

I1K753_SOYBN (tr|I1K753) Bifunctional dihydrofolate reductase-th...   898   0.0  
I1K754_SOYBN (tr|I1K754) Bifunctional dihydrofolate reductase-th...   897   0.0  
K7KHI6_SOYBN (tr|K7KHI6) Bifunctional dihydrofolate reductase-th...   884   0.0  
Q8L6F0_PEA (tr|Q8L6F0) Dihydrofolate reductase-thymidylate synth...   871   0.0  
K7LP84_SOYBN (tr|K7LP84) Bifunctional dihydrofolate reductase-th...   867   0.0  
I1LQ11_SOYBN (tr|I1LQ11) Bifunctional dihydrofolate reductase-th...   863   0.0  
G7J766_MEDTR (tr|G7J766) Dihydrofolate reductase-thymidylate syn...   855   0.0  
G7J765_MEDTR (tr|G7J765) Dihydrofolate reductase-thymidylate syn...   855   0.0  
K7LSY4_SOYBN (tr|K7LSY4) Bifunctional dihydrofolate reductase-th...   848   0.0  
B9H0T4_POPTR (tr|B9H0T4) Dihydrofolate reductase-thymidylate syn...   847   0.0  
M5VK78_PRUPE (tr|M5VK78) Uncharacterized protein OS=Prunus persi...   847   0.0  
B0BLI5_LOTJA (tr|B0BLI5) CM0216.390.nc protein OS=Lotus japonicu...   838   0.0  
F6I0M2_VITVI (tr|F6I0M2) Putative uncharacterized protein OS=Vit...   830   0.0  
G7JHF2_MEDTR (tr|G7JHF2) Bifunctional dihydrofolate reductase-th...   825   0.0  
B9RH79_RICCO (tr|B9RH79) Bifunctional dihydrofolate reductase-th...   822   0.0  
M0ZJD1_SOLTU (tr|M0ZJD1) Bifunctional dihydrofolate reductase-th...   816   0.0  
K4B3J6_SOLLC (tr|K4B3J6) Bifunctional dihydrofolate reductase-th...   813   0.0  
Q39687_DAUCA (tr|Q39687) Dihydrofolate reductase-thymidylate syn...   796   0.0  
K3ZSB7_SETIT (tr|K3ZSB7) Bifunctional dihydrofolate reductase-th...   795   0.0  
C5Y2E9_SORBI (tr|C5Y2E9) Putative uncharacterized protein Sb05g0...   794   0.0  
B9GCZ3_ORYSJ (tr|B9GCZ3) Putative uncharacterized protein OS=Ory...   793   0.0  
D7L1V0_ARALL (tr|D7L1V0) Dihydrofolate reductase-thymidylate syn...   787   0.0  
K7UAA2_MAIZE (tr|K7UAA2) Bifunctional dihydrofolate reductase-th...   787   0.0  
K3ZI20_SETIT (tr|K3ZI20) Bifunctional dihydrofolate reductase-th...   787   0.0  
B6UD82_MAIZE (tr|B6UD82) Bifunctional dihydrofolate reductase-th...   786   0.0  
Q2R481_ORYSJ (tr|Q2R481) Bifunctional dihydrofolate reductase-th...   785   0.0  
I1R077_ORYGL (tr|I1R077) Bifunctional dihydrofolate reductase-th...   783   0.0  
I1IIJ7_BRADI (tr|I1IIJ7) Bifunctional dihydrofolate reductase-th...   780   0.0  
R0HKJ0_9BRAS (tr|R0HKJ0) Uncharacterized protein (Fragment) OS=C...   780   0.0  
J3MF38_ORYBR (tr|J3MF38) Bifunctional dihydrofolate reductase-th...   779   0.0  
B9GAQ2_ORYSJ (tr|B9GAQ2) Putative uncharacterized protein OS=Ory...   774   0.0  
M7YZH3_TRIUA (tr|M7YZH3) Putative bifunctional dihydrofolate red...   773   0.0  
D7MEC7_ARALL (tr|D7MEC7) Predicted protein OS=Arabidopsis lyrata...   770   0.0  
R7WB22_AEGTA (tr|R7WB22) Putative bifunctional dihydrofolate red...   768   0.0  
R0F3G9_9BRAS (tr|R0F3G9) Uncharacterized protein OS=Capsella rub...   768   0.0  
F6H1I8_VITVI (tr|F6H1I8) Putative uncharacterized protein OS=Vit...   768   0.0  
B8BPG2_ORYSI (tr|B8BPG2) Putative uncharacterized protein OS=Ory...   767   0.0  
B7FA29_ORYSJ (tr|B7FA29) cDNA, clone: J100037K11, full insert se...   767   0.0  
M4D4Y6_BRARP (tr|M4D4Y6) Bifunctional dihydrofolate reductase-th...   766   0.0  
I1R663_ORYGL (tr|I1R663) Bifunctional dihydrofolate reductase-th...   765   0.0  
M0YHZ0_HORVD (tr|M0YHZ0) Bifunctional dihydrofolate reductase-th...   764   0.0  
F2DUZ4_HORVD (tr|F2DUZ4) Bifunctional dihydrofolate reductase-th...   763   0.0  
M4D9B9_BRARP (tr|M4D9B9) Bifunctional dihydrofolate reductase-th...   762   0.0  
J3ND79_ORYBR (tr|J3ND79) Uncharacterized protein OS=Oryza brachy...   761   0.0  
K3ZSR0_SETIT (tr|K3ZSR0) Bifunctional dihydrofolate reductase-th...   745   0.0  
B9R7Y4_RICCO (tr|B9R7Y4) Bifunctional dihydrofolate reductase-th...   743   0.0  
G7J767_MEDTR (tr|G7J767) Bifunctional dihydrofolate reductase-th...   739   0.0  
M4DMC9_BRARP (tr|M4DMC9) Bifunctional dihydrofolate reductase-th...   736   0.0  
D8SA97_SELML (tr|D8SA97) Putative uncharacterized protein OS=Sel...   678   0.0  
D8QVP4_SELML (tr|D8QVP4) Putative uncharacterized protein OS=Sel...   676   0.0  
B9HRK6_POPTR (tr|B9HRK6) Dihydrofolate reductase-thymidylate syn...   658   0.0  
A9RXS0_PHYPA (tr|A9RXS0) Predicted protein OS=Physcomitrella pat...   658   0.0  
Q01FK1_OSTTA (tr|Q01FK1) Bifunctional dihydrofolate reductase-th...   618   e-174
A4RXM1_OSTLU (tr|A4RXM1) Predicted protein OS=Ostreococcus lucim...   612   e-172
C1MMA6_MICPC (tr|C1MMA6) Bifunctional dihydrofolate reductase-th...   598   e-168
E1ZCI9_CHLVA (tr|E1ZCI9) Putative uncharacterized protein OS=Chl...   596   e-168
M0S7X1_MUSAM (tr|M0S7X1) Uncharacterized protein OS=Musa acumina...   591   e-166
C1E6F7_MICSR (tr|C1E6F7) Bifunctional dihydrofolate reductase-th...   590   e-166
I0YVC8_9CHLO (tr|I0YVC8) Bifunctional dihydrofolate reductase-th...   578   e-162
K8ECA8_9CHLO (tr|K8ECA8) Bifunctional dihydrofolate reductase-th...   574   e-161
A8JD96_CHLRE (tr|A8JD96) Predicted protein OS=Chlamydomonas rein...   546   e-152
D8UB22_VOLCA (tr|D8UB22) Putative uncharacterized protein OS=Vol...   538   e-150
Q9SIK4_ARATH (tr|Q9SIK4) Bifunctional dihydrofolate reductase-th...   536   e-150
L1JGV3_GUITH (tr|L1JGV3) Bifunctional dihydrofolate reductase-th...   536   e-150
D7LBE8_ARALL (tr|D7LBE8) Predicted protein OS=Arabidopsis lyrata...   516   e-144
G4YSZ0_PHYSP (tr|G4YSZ0) Putative uncharacterized protein OS=Phy...   510   e-142
H3GWN7_PHYRM (tr|H3GWN7) Uncharacterized protein OS=Phytophthora...   509   e-142
D0N806_PHYIT (tr|D0N806) Bifunctional dihydrofolate reductase-th...   507   e-141
M4BX13_HYAAE (tr|M4BX13) Bifunctional dihydrofolate reductase-th...   506   e-140
B8BKI9_ORYSI (tr|B8BKI9) Putative uncharacterized protein OS=Ory...   504   e-140
F0YJX9_AURAN (tr|F0YJX9) Putative uncharacterized protein OS=Aur...   501   e-139
R0FWL1_9BRAS (tr|R0FWL1) Uncharacterized protein OS=Capsella rub...   499   e-139
F0W9B4_9STRA (tr|F0W9B4) Bifunctional dihydrofolate reductasethy...   495   e-137
D8LWN8_BLAHO (tr|D8LWN8) Thymidylate synthase OS=Blastocystis ho...   491   e-136
B7FQJ9_PHATC (tr|B7FQJ9) Predicted protein (Fragment) OS=Phaeoda...   479   e-133
K0T9B5_THAOC (tr|K0T9B5) Uncharacterized protein OS=Thalassiosir...   478   e-132
R7Q5X1_CHOCR (tr|R7Q5X1) Bifunctional dihydrofolate reductase (D...   474   e-131
Q22KR8_TETTS (tr|Q22KR8) Bifunctional dihydrofolate reductase-th...   471   e-130
C5LQI2_PERM5 (tr|C5LQI2) Dihydrofolate reductase-thymidylate syn...   469   e-129
M4C8Q3_BRARP (tr|M4C8Q3) Uncharacterized protein OS=Brassica rap...   468   e-129
B5YMV7_THAPS (tr|B5YMV7) Possible thymidylate synthase (Fragment...   468   e-129
J9FQF0_9SPIT (tr|J9FQF0) Bifunctional dihydrofolate reductase-th...   456   e-126
M2Y9L6_GALSU (tr|M2Y9L6) Thymidylate synthase/dihydrofolate redu...   451   e-124
G0TZ26_TRYVY (tr|G0TZ26) Putative dihydrofolate reductase-thymid...   446   e-123
R1BUZ9_EMIHU (tr|R1BUZ9) Uncharacterized protein OS=Emiliania hu...   446   e-122
M1VHU6_CYAME (tr|M1VHU6) Fusion protein of dihydrofolate reducta...   444   e-122
M0YHZ1_HORVD (tr|M0YHZ1) Thymidylate synthase OS=Hordeum vulgare...   442   e-121
I7IGH8_BABMI (tr|I7IGH8) Chromosome II, complete genome OS=Babes...   440   e-121
H8ZWN9_9EUKA (tr|H8ZWN9) Dihydrofolate reductase-thymidylate syn...   433   e-118
Q582G3_TRYB2 (tr|Q582G3) Bifunctional dihydrofolate reductase-th...   432   e-118
Q8MXB7_LEITR (tr|Q8MXB7) Dihydrofolate reductase-thymidylate syn...   432   e-118
C9ZTK8_TRYB9 (tr|C9ZTK8) Dihydrofolate reductase-thymidylate syn...   431   e-118
Q8MXB8_LEITR (tr|Q8MXB8) Dihydrofolate reductase-thymidylate syn...   431   e-118
E9AKW4_LEIMU (tr|E9AKW4) Dihydrofolate reductase-thymidylate syn...   430   e-118
Q8T5T9_TRYCR (tr|Q8T5T9) Dihydrofolate reductase-thymidylate syn...   428   e-117
Q8T5T8_TRYCR (tr|Q8T5T8) Bifunctional dihydrofolate reductase-th...   428   e-117
Q4DLS1_TRYCC (tr|Q4DLS1) Dihydrofolate reductase-thymidylate syn...   427   e-117
Q8MQV3_LEIIN (tr|Q8MQV3) Bifunctional dihydrofolate reductase-th...   427   e-117
Q8MQV1_LEICH (tr|Q8MQV1) Dhfr-ts OS=Leishmania chagasi PE=3 SV=1      426   e-117
K2NID0_TRYCR (tr|K2NID0) Bifunctional dihydrofolate reductase-th...   426   e-117
H9AZH4_TRYCR (tr|H9AZH4) Bifunctional dihydrofolate reductase-th...   424   e-116
A4H4P8_LEIBR (tr|A4H4P8) Dihydrofolate reductase-thymidylate syn...   424   e-116
H9AZH1_TRYCR (tr|H9AZH1) Bifunctional dihydrofolate reductase-th...   424   e-116
E9B8U9_LEIDB (tr|E9B8U9) Dihydrofolate reductase-thymidylate syn...   424   e-116
L0B0P3_BABEQ (tr|L0B0P3) Bifunctional dihydrofolate reductase-th...   424   e-116
B5U9U8_BABGI (tr|B5U9U8) Dihydrofolate reductase-thymidylate syn...   423   e-115
I6LEA2_TRYCR (tr|I6LEA2) Bifunctional dihydrofolate reductase-th...   421   e-115
I6LEA8_TRYCR (tr|I6LEA8) Bifunctional dihydrofolate reductase-th...   421   e-115
Q963S7_9TRYP (tr|Q963S7) Bifunctional dihydrofolate reductase-th...   419   e-114
Q95NI3_TRYCR (tr|Q95NI3) Bifunctional dihydrofolate reductase-th...   419   e-114
Q0IK63_TRYCR (tr|Q0IK63) Bifunctional dihydrofolate reductase-th...   419   e-114
I6LEA0_TRYCR (tr|I6LEA0) Bifunctional dihydrofolate reductase-th...   419   e-114
Q95NS0_TRYCR (tr|Q95NS0) Bifunctional dihydrofolate reductase-th...   419   e-114
I6LEA3_TRYCR (tr|I6LEA3) Bifunctional dihydrofolate reductase-th...   419   e-114
Q95NX3_TRYCR (tr|Q95NX3) Bifunctional dihydrofolate reductase-th...   419   e-114
D3JL87_TRYCR (tr|D3JL87) Bifunctional dihydrofolate reductase-th...   418   e-114
D3JLA1_TRYCR (tr|D3JLA1) Bifunctional dihydrofolate reductase-th...   418   e-114
D3JL82_TRYCR (tr|D3JL82) Bifunctional dihydrofolate reductase-th...   418   e-114
Q95NY4_TRYCR (tr|Q95NY4) Bifunctional dihydrofolate reductase-th...   417   e-114
Q95NT2_TRYCR (tr|Q95NT2) Bifunctional dihydrofolate reductase-th...   417   e-114
D3JLB2_TRYCR (tr|D3JLB2) Bifunctional dihydrofolate reductase-th...   417   e-114
D3JL86_TRYCR (tr|D3JL86) Bifunctional dihydrofolate reductase-th...   417   e-114
I6LEA6_TRYCR (tr|I6LEA6) Bifunctional dihydrofolate reductase-th...   417   e-114
D3JL83_TRYCR (tr|D3JL83) Bifunctional dihydrofolate reductase-th...   417   e-114
D3JL96_TRYCR (tr|D3JL96) Bifunctional dihydrofolate reductase-th...   417   e-114
I6LE99_TRYCR (tr|I6LE99) Bifunctional dihydrofolate reductase-th...   417   e-114
D3JLB1_TRYCR (tr|D3JLB1) Bifunctional dihydrofolate reductase-th...   416   e-114
I6LEA1_TRYCR (tr|I6LEA1) Bifunctional dihydrofolate reductase-th...   416   e-113
D3JLA6_TRYCR (tr|D3JLA6) Bifunctional dihydrofolate reductase-th...   416   e-113
I6LEA5_TRYCR (tr|I6LEA5) Bifunctional dihydrofolate reductase-th...   416   e-113
Q963S8_TRYCR (tr|Q963S8) Bifunctional dihydrofolate reductase-th...   416   e-113
I6LEA7_TRYCR (tr|I6LEA7) Bifunctional dihydrofolate reductase-th...   416   e-113
R4KZ58_NEOCA (tr|R4KZ58) Bifunctional dihydrofolate reductase/th...   415   e-113
R7V2Q2_9ANNE (tr|R7V2Q2) Uncharacterized protein OS=Capitella te...   414   e-113
Q4A320_EHV8U (tr|Q4A320) Bifunctional dihydrofolate reductase-th...   414   e-113
G4YAN7_9PHYC (tr|G4YAN7) Thymidylate synthase OS=Emiliania huxle...   414   e-113
G3GPB6_9PHYC (tr|G3GPB6) Thymidylate synthase OS=Emiliania huxle...   414   e-113
I6LEA4_TRYCR (tr|I6LEA4) Bifunctional dihydrofolate reductase-th...   413   e-112
D2TF54_9PHYC (tr|D2TF54) Bifunctional dihydrofolate reductase-th...   412   e-112
D8LBA4_ECTSI (tr|D8LBA4) Putative uncharacterized protein OS=Ect...   412   e-112
G4YD93_9PHYC (tr|G4YD93) Thymidylate synthase OS=Emiliania huxle...   412   e-112
G4YBY6_9PHYC (tr|G4YBY6) Thymidylate synthase OS=Emiliania huxle...   412   e-112
G3GPM8_9PHYC (tr|G3GPM8) Thymidylate synthase OS=Emiliania huxle...   412   e-112
G9E3L7_9PHYC (tr|G9E3L7) Thymidylate synthase OS=Emiliania huxle...   412   e-112
E0DA52_NEOCA (tr|E0DA52) Dihydrofolate reductase OS=Neospora can...   411   e-112
G8DFJ0_9PHYC (tr|G8DFJ0) Thymidylate synthase OS=Emiliania huxle...   411   e-112
D3JLA7_TRYCR (tr|D3JLA7) Bifunctional dihydrofolate reductase-th...   410   e-112
B6AE97_CRYMR (tr|B6AE97) Thymidylate synthase family protein OS=...   410   e-112
F2ULJ1_SALS5 (tr|F2ULJ1) Thymidylate synthase OS=Salpingoeca sp....   407   e-111
J4C4E3_THEOR (tr|J4C4E3) Bifunctional dihydrofolate reductase/th...   406   e-110
Q7RGH7_PLAYO (tr|Q7RGH7) Thymidylate synthase, putative OS=Plasm...   406   e-110
H2YU26_CIOSA (tr|H2YU26) Uncharacterized protein OS=Ciona savign...   405   e-110
Q95US9_PLAGA (tr|Q95US9) Dihydrofolate reductase/thymidylate syn...   405   e-110
Q4U9G5_THEAN (tr|Q4U9G5) Bifunctional dihydrofolate reductase/th...   405   e-110
D3VZW1_9APIC (tr|D3VZW1) Bifunctional dihydrofolate reductase-th...   404   e-110
Q4XXZ2_PLACH (tr|Q4XXZ2) Bifunctional dihydrofolate reductase-th...   403   e-110
D3VZW2_9APIC (tr|D3VZW2) Bifunctional dihydrofolate reductase-th...   403   e-109
K1QYM1_CRAGI (tr|K1QYM1) Thymidylate synthase OS=Crassostrea gig...   403   e-109
D9N170_PLAFA (tr|D9N170) Bifunctional dihydrofolate reductase-th...   402   e-109
C3S7P8_PLAFA (tr|C3S7P8) Dihydrofolate reductase/thymidylate syn...   402   e-109
Q19N46_PLAVI (tr|Q19N46) Dihydrofolate reductase-thymidylate syn...   401   e-109
A7UD79_PLAFA (tr|A7UD79) Bifunctional dihydrofolate reductase-th...   401   e-109
Q8I1R6_PLAF7 (tr|Q8I1R6) Bifunctional dihydrofolate reductase-th...   401   e-109
K7J2X4_NASVI (tr|K7J2X4) Thymidylate synthase OS=Nasonia vitripe...   401   e-109
A7UD81_PLAFA (tr|A7UD81) Bifunctional dihydrofolate reductase-th...   401   e-109
E9GKZ0_DAPPU (tr|E9GKZ0) Putative uncharacterized protein OS=Dap...   399   e-108
Q19PB8_PLAVI (tr|Q19PB8) Dihydrofolate reductase-thymidylate syn...   399   e-108
D3VZV8_PLARE (tr|D3VZV8) Bifunctional dihydrofolate reductase-th...   399   e-108
A8C2U7_PLABR (tr|A8C2U7) Dihydrofolate reductase-thymidylate syn...   399   e-108
E2C405_HARSA (tr|E2C405) Thymidylate synthase OS=Harpegnathos sa...   399   e-108
A8C2U4_PLAMA (tr|A8C2U4) Dihydrofolate reductase-thymidylate syn...   399   e-108
Q19N43_PLAVI (tr|Q19N43) Dihydrofolate reductase-thymidylate syn...   399   e-108
Q0IJY2_PLAMA (tr|Q0IJY2) Bifunctional dihydrofolate reductase-th...   399   e-108
I1G066_AMPQE (tr|I1G066) Thymidylate synthase OS=Amphimedon quee...   399   e-108
Q19N44_PLAVI (tr|Q19N44) Bifunctional dihydrofolate reductase-th...   398   e-108
Q19N45_PLAVI (tr|Q19N45) Dihydrofolate reductase-thymidylate syn...   398   e-108
Q7Z0Z9_BABBO (tr|Q7Z0Z9) Dihydrofolate reductase/thymidilate syn...   398   e-108
Q5CGA3_CRYHO (tr|Q5CGA3) Chain A, crystal structure of Dhfr OS=C...   398   e-108
Q27552_CRYPV (tr|Q27552) Bifunctional dihydrofolate reductase-th...   398   e-108
Q4N262_THEPA (tr|Q4N262) Dihydrofolate reductase-thymidylate syn...   398   e-108
A8C2U6_PLAMA (tr|A8C2U6) Dihydrofolate reductase-thymidylate syn...   398   e-108
A8C2U2_PLAMA (tr|A8C2U2) Dihydrofolate reductase-thymidylate syn...   398   e-108
Q19PC0_PLAVI (tr|Q19PC0) Dihydrofolate reductase-thymidylate syn...   397   e-108
C3RUA6_PLAVI (tr|C3RUA6) Dihydrofolate reductase-thymidylate syn...   397   e-108
Q19N42_PLAVI (tr|Q19N42) Dihydrofolate reductase-thymidylate syn...   397   e-108
E9IYA3_SOLIN (tr|E9IYA3) Thymidylate synthase (Fragment) OS=Sole...   397   e-108
C3RUA8_PLAVI (tr|C3RUA8) Bifunctional dihydrofolate reductase-th...   397   e-108
A5K620_PLAVS (tr|A5K620) Bifunctional dihydrofolate reductase-th...   397   e-108
C6GJB8_LITVA (tr|C6GJB8) Thymidylate synthase OS=Litopenaeus van...   397   e-108
Q19PB9_PLAVI (tr|Q19PB9) Dihydrofolate reductase-thymidylate syn...   397   e-108
Q4YWH2_PLABA (tr|Q4YWH2) Bifunctional dihydrofolate reductase-th...   397   e-108
Q5CPQ4_CRYPI (tr|Q5CPQ4) Bifunctional dihydrofolate reductase-th...   397   e-108
C3RUA7_PLAVI (tr|C3RUA7) Dihydrofolate reductase-thymidylate syn...   397   e-108
C3RUB1_PLAVI (tr|C3RUB1) Dihydrofolate reductase-thymidylate syn...   397   e-108
D2A1S6_TRICA (tr|D2A1S6) Putative uncharacterized protein GLEAN_...   396   e-107
D3VZW0_9APIC (tr|D3VZW0) Bifunctional dihydrofolate reductase-th...   395   e-107
D3VZV9_PLARE (tr|D3VZV9) Bifunctional dihydrofolate reductase-th...   395   e-107
Q19N40_PLAVI (tr|Q19N40) Dihydrofolate reductase-thymidylate syn...   395   e-107
A7ASX7_BABBO (tr|A7ASX7) Dihydrofolate reductase/thymidylate syn...   395   e-107
H9HVD5_ATTCE (tr|H9HVD5) Uncharacterized protein OS=Atta cephalo...   395   e-107
C3RUB2_PLAVI (tr|C3RUB2) Dihydrofolate reductase-thymidylate syn...   395   e-107
A7RH38_NEMVE (tr|A7RH38) Predicted protein OS=Nematostella vecte...   395   e-107
Q19N41_PLAVI (tr|Q19N41) Dihydrofolate reductase-thymidylate syn...   394   e-107
B3NAN1_DROER (tr|B3NAN1) GG24473 OS=Drosophila erecta GN=Dere\GG...   393   e-106
F4X867_ACREC (tr|F4X867) Thymidylate synthase OS=Acromyrmex echi...   392   e-106
F0VQW6_NEOCL (tr|F0VQW6) Bifunctional dihydrofolate reductase-th...   392   e-106
D2W4C0_NAEGR (tr|D2W4C0) Predicted protein OS=Naegleria gruberi ...   390   e-106
F7G371_MONDO (tr|F7G371) Thymidylate synthase OS=Monodelphis dom...   388   e-105
H0VTN7_CAVPO (tr|H0VTN7) Uncharacterized protein OS=Cavia porcel...   388   e-105
M3ZJ50_XIPMA (tr|M3ZJ50) Thymidylate synthase OS=Xiphophorus mac...   387   e-105
B0WW05_CULQU (tr|B0WW05) Thymidylate synthase OS=Culex quinquefa...   387   e-105
Q27551_CRYPV (tr|Q27551) Bifunctional dihydrofolate reductase-th...   386   e-104
Q544L2_MOUSE (tr|Q544L2) Thymidylate synthase OS=Mus musculus GN...   385   e-104
H2M5Y9_ORYLA (tr|H2M5Y9) Uncharacterized protein OS=Oryzias lati...   384   e-104
K7J2H1_NASVI (tr|K7J2H1) Thymidylate synthase OS=Nasonia vitripe...   384   e-104
Q6P045_DANRE (tr|Q6P045) Thymidylate synthase OS=Danio rerio GN=...   384   e-104
H0XYX0_OTOGA (tr|H0XYX0) Uncharacterized protein OS=Otolemur gar...   383   e-104
Q8VDV6_MOUSE (tr|Q8VDV6) Tyms protein OS=Mus musculus GN=Tyms PE...   383   e-104
G1TZX9_RABIT (tr|G1TZX9) Thymidylate synthase (Fragment) OS=Oryc...   383   e-104
F6TRC0_HORSE (tr|F6TRC0) Uncharacterized protein OS=Equus caball...   383   e-104
G1SVL8_RABIT (tr|G1SVL8) Uncharacterized protein OS=Oryctolagus ...   383   e-104
Q06BX0_9CILI (tr|Q06BX0) Dihydrofolate reductase-thymidylate syn...   383   e-103
F7GTE7_CALJA (tr|F7GTE7) Uncharacterized protein OS=Callithrix j...   383   e-103
Q7ZUI7_DANRE (tr|Q7ZUI7) Tyms protein OS=Danio rerio GN=tyms PE=...   382   e-103
Q9DGH5_DANRE (tr|Q9DGH5) Thymidylate synthase OS=Danio rerio GN=...   382   e-103
E3XAX1_ANODA (tr|E3XAX1) Uncharacterized protein OS=Anopheles da...   382   e-103
Q9D0H1_MOUSE (tr|Q9D0H1) Putative uncharacterized protein OS=Mus...   382   e-103
Q16JK1_AEDAE (tr|Q16JK1) AAEL013305-PA OS=Aedes aegypti GN=AAEL0...   381   e-103
Q06BX2_9CILI (tr|Q06BX2) Dihydrofolate reductase-thymidylate syn...   380   e-103
G3IFY1_CRIGR (tr|G3IFY1) Thymidylate synthase OS=Cricetulus gris...   380   e-103
G3TE40_LOXAF (tr|G3TE40) Thymidylate synthase (Fragment) OS=Loxo...   380   e-103
I3JFM1_ORENI (tr|I3JFM1) Thymidylate synthase OS=Oreochromis nil...   380   e-103
E2B1J5_CAMFO (tr|E2B1J5) Thymidylate synthase OS=Camponotus flor...   380   e-103
D7EIA1_TRICA (tr|D7EIA1) Putative uncharacterized protein OS=Tri...   380   e-102
F6ZR77_MACMU (tr|F6ZR77) Thymidylate synthase OS=Macaca mulatta ...   379   e-102
F1PU23_CANFA (tr|F1PU23) Uncharacterized protein OS=Canis famili...   379   e-102
Q53Y97_HUMAN (tr|Q53Y97) Thymidylate synthase OS=Homo sapiens GN...   379   e-102
G2HEY4_PANTR (tr|G2HEY4) Thymidylate synthase OS=Pan troglodytes...   379   e-102
B4KHK2_DROMO (tr|B4KHK2) GI10845 OS=Drosophila mojavensis GN=Dmo...   379   e-102
H2NVZ8_PONAB (tr|H2NVZ8) Uncharacterized protein (Fragment) OS=P...   379   e-102
A8K9A5_HUMAN (tr|A8K9A5) cDNA FLJ78114, highly similar to Homo s...   379   e-102
J3JUF8_9CUCU (tr|J3JUF8) Uncharacterized protein OS=Dendroctonus...   379   e-102
K7EU16_PONAB (tr|K7EU16) Thymidylate synthase OS=Pongo abelii GN...   379   e-102
B4NXB1_DROYA (tr|B4NXB1) GE14974 OS=Drosophila yakuba GN=Dyak\GE...   379   e-102
B3RLB4_TRIAD (tr|B3RLB4) Putative uncharacterized protein OS=Tri...   379   e-102
C3ZXJ5_BRAFL (tr|C3ZXJ5) Putative uncharacterized protein OS=Bra...   378   e-102
B4JCJ9_DROGR (tr|B4JCJ9) GH10649 OS=Drosophila grimshawi GN=Dgri...   378   e-102
Q53FB7_HUMAN (tr|Q53FB7) Thymidylate synthase (Fragment) OS=Homo...   377   e-102
Q9E202_9ALPH (tr|Q9E202) Thymidylate synthetase OS=Cercopithecin...   377   e-102
F7GTH3_CALJA (tr|F7GTH3) Uncharacterized protein OS=Callithrix j...   377   e-102
H0ZIT6_TAEGU (tr|H0ZIT6) Thymidylate synthase (Fragment) OS=Taen...   377   e-102
M3Y229_MUSPF (tr|M3Y229) Thymidylate synthase OS=Mustela putoriu...   377   e-102
M3WB14_FELCA (tr|M3WB14) Thymidylate synthase OS=Felis catus GN=...   377   e-102
B4Q910_DROSI (tr|B4Q910) GD22790 OS=Drosophila simulans GN=Dsim\...   376   e-101
Q06BX1_9CILI (tr|Q06BX1) Dihydrofolate reductase-thymidylate syn...   375   e-101
H2RXT1_TAKRU (tr|H2RXT1) Thymidylate synthase (Fragment) OS=Taki...   375   e-101
Q541C9_DROME (tr|Q541C9) RE18955p OS=Drosophila melanogaster GN=...   375   e-101
G7PWG5_MACFA (tr|G7PWG5) Thymidylate synthase OS=Macaca fascicul...   375   e-101
H2M5Y8_ORYLA (tr|H2M5Y8) Uncharacterized protein OS=Oryzias lati...   374   e-101
K7TWH4_MAIZE (tr|K7TWH4) Uncharacterized protein OS=Zea mays GN=...   374   e-101
B4M9C1_DROVI (tr|B4M9C1) GJ18288 OS=Drosophila virilis GN=Dvir\G...   374   e-101
G1KHU7_ANOCA (tr|G1KHU7) Uncharacterized protein OS=Anolis carol...   374   e-101
C0H809_SALSA (tr|C0H809) Thymidylate synthase OS=Salmo salar GN=...   374   e-101
E9BWM4_CAPO3 (tr|E9BWM4) Thymidylate synthase OS=Capsaspora owcz...   374   e-101
C4WVP2_ACYPI (tr|C4WVP2) Thymidylate synthase OS=Acyrthosiphon p...   373   e-101
G1LJ65_AILME (tr|G1LJ65) Thymidylate synthase (Fragment) OS=Ailu...   373   e-101
B4NLJ1_DROWI (tr|B4NLJ1) GK18389 OS=Drosophila willistoni GN=Dwi...   373   e-101
G3NJA3_GASAC (tr|G3NJA3) Thymidylate synthase (Fragment) OS=Gast...   373   e-100
D2HJY4_AILME (tr|D2HJY4) Thymidylate synthase (Fragment) OS=Ailu...   372   e-100
H9K8H1_APIME (tr|H9K8H1) Uncharacterized protein OS=Apis mellife...   372   e-100
B4GSA5_DROPE (tr|B4GSA5) GL26706 OS=Drosophila persimilis GN=Dpe...   372   e-100
Q7QDW7_ANOGA (tr|Q7QDW7) AGAP010457-PA OS=Anopheles gambiae GN=A...   372   e-100
C5KZ80_PERM5 (tr|C5KZ80) Dihydrofolate reductase/thymidilate syn...   372   e-100
Q29KG5_DROPS (tr|Q29KG5) GA16493 OS=Drosophila pseudoobscura pse...   372   e-100
E0VDQ0_PEDHC (tr|E0VDQ0) Thymidylate synthase, putative OS=Pedic...   372   e-100
B4I2T1_DROSE (tr|B4I2T1) GM18183 OS=Drosophila sechellia GN=Dsec...   371   e-100
B3MLB9_DROAN (tr|B3MLB9) GF14907 OS=Drosophila ananassae GN=Dana...   371   e-100
F6TYZ6_ORNAN (tr|F6TYZ6) Uncharacterized protein OS=Ornithorhync...   370   e-100
Q0IHX3_XENTR (tr|Q0IHX3) Thymidylate synthetase OS=Xenopus tropi...   370   e-100
B5XCJ1_SALSA (tr|B5XCJ1) Thymidylate synthase OS=Salmo salar GN=...   370   e-100
F6WWH6_XENTR (tr|F6WWH6) Uncharacterized protein OS=Xenopus trop...   370   e-100
A1L2V6_XENLA (tr|A1L2V6) Ts protein OS=Xenopus laevis GN=tyms PE...   370   e-100
E6ZJ38_DICLA (tr|E6ZJ38) Thymidylate synthase OS=Dicentrarchus l...   370   1e-99
B4NBS5_DROWI (tr|B4NBS5) GK18710 OS=Drosophila willistoni GN=Dwi...   369   2e-99
R0KEF4_ANAPL (tr|R0KEF4) Thymidylate synthase (Fragment) OS=Anas...   368   3e-99
G9KW42_MUSPF (tr|G9KW42) Thymidylate synthase (Fragment) OS=Must...   368   3e-99
C1BZP1_ESOLU (tr|C1BZP1) Thymidylate synthase OS=Esox lucius GN=...   367   6e-99
F1N8Y2_CHICK (tr|F1N8Y2) Thymidylate synthase (Fragment) OS=Gall...   367   6e-99
E9GKZ1_DAPPU (tr|E9GKZ1) Putative uncharacterized protein OS=Dap...   367   6e-99
F1MY63_BOVIN (tr|F1MY63) Thymidylate synthase OS=Bos taurus GN=T...   367   9e-99
D5GJQ2_TUBMM (tr|D5GJQ2) Whole genome shotgun sequence assembly,...   364   6e-98
I2BFL1_9VIRU (tr|I2BFL1) Thymidylate synthase OS=European catfis...   364   6e-98
Q91CH7_9ALPH (tr|Q91CH7) Thymidylate synthase OS=Macropodid herp...   362   1e-97
B9PR34_TOXGO (tr|B9PR34) Bifunctional dihydrofolate reductase-th...   362   2e-97
Q9NDD3_TRISP (tr|Q9NDD3) Thymidylate synthase OS=Trichinella spi...   362   2e-97
F5HBQ9_HHV8 (tr|F5HBQ9) Thymidylate synthase OS=Human herpesviru...   361   3e-97
Q5DGT4_SCHJA (tr|Q5DGT4) SJCHGC01067 protein OS=Schistosoma japo...   361   4e-97
G4V8Q8_SCHMA (tr|G4V8Q8) Putative uncharacterized protein Smp_20...   361   5e-97
F1PNL9_CANFA (tr|F1PNL9) Uncharacterized protein OS=Canis famili...   360   9e-97
Q9YTJ6_ATHV3 (tr|Q9YTJ6) Thymidylate synthase OS=Ateline herpesv...   360   9e-97
G1PE11_MYOLU (tr|G1PE11) Uncharacterized protein OS=Myotis lucif...   360   1e-96
G0R390_ICHMG (tr|G0R390) Thymidylate synthetase, putative OS=Ich...   359   1e-96
L7M0X3_9ACAR (tr|L7M0X3) Thymidylate synthase OS=Rhipicephalus p...   359   1e-96
G1R568_NOMLE (tr|G1R568) Thymidylate synthase (Fragment) OS=Noma...   359   2e-96
E4YJV3_OIKDI (tr|E4YJV3) Whole genome shotgun assembly, allelic ...   359   2e-96
E4WSC6_OIKDI (tr|E4WSC6) Whole genome shotgun assembly, referenc...   358   3e-96
Q80BK9_SHV2 (tr|Q80BK9) Thymidylate synthase OS=Saimiriine herpe...   357   8e-96
L8FWN4_GEOD2 (tr|L8FWN4) Thymidylate synthase OS=Geomyces destru...   356   1e-95
M7PCC8_9ASCO (tr|M7PCC8) Thymidylate synthase OS=Pneumocystis mu...   356   1e-95
G1NBS7_MELGA (tr|G1NBS7) Thymidylate synthase (Fragment) OS=Mele...   355   2e-95
L5LZV4_MYODS (tr|L5LZV4) Thymidylate synthase OS=Myotis davidii ...   355   3e-95
G6CUW4_DANPL (tr|G6CUW4) Thymidylate synthase isoform 1 OS=Danau...   355   3e-95
R7VP42_COLLI (tr|R7VP42) Thymidylate synthase (Fragment) OS=Colu...   354   4e-95
E6ZV93_SPORE (tr|E6ZV93) Related to thymidylate synthase OS=Spor...   354   4e-95
G3VK27_SARHA (tr|G3VK27) Uncharacterized protein (Fragment) OS=S...   352   2e-94
B7QMU1_IXOSC (tr|B7QMU1) Dihydrofolate reductase-thymidylate syn...   351   4e-94
R4G4B0_RHOPR (tr|R4G4B0) Putative thymidylate synthase OS=Rhodni...   351   5e-94
G8BYM5_TETPH (tr|G8BYM5) Uncharacterized protein OS=Tetrapisispo...   351   5e-94
H2AYN8_KAZAF (tr|H2AYN8) Uncharacterized protein OS=Kazachstania...   350   6e-94
Q2F5K5_BOMMO (tr|Q2F5K5) Thymidylate synthase isoform 1 OS=Bomby...   350   7e-94
J5Q8N4_TRIAS (tr|J5Q8N4) Thymidylate synthase OS=Trichosporon as...   350   1e-93
I1BT39_RHIO9 (tr|I1BT39) Thymidylate synthase OS=Rhizopus delema...   349   2e-93
K1WHU0_MARBU (tr|K1WHU0) Thymidylate synthase OS=Marssonina brun...   348   2e-93
B7QLC8_IXOSC (tr|B7QLC8) Dihydrofolate reductase-thymidylate syn...   348   2e-93
Q91LI6_WSSV (tr|Q91LI6) ORF54, putative thymidylate synthase OS=...   348   3e-93
Q77J90_WSSVS (tr|Q77J90) Wsv067 OS=White spot syndrome virus (is...   348   3e-93
Q53D48_9GAMA (tr|Q53D48) Thymidylate synthase OS=Macaca fuscata ...   348   3e-93
K2SFK0_MACPH (tr|K2SFK0) Thymidylate synthase OS=Macrophomina ph...   348   4e-93
Q9J2M3_9GAMA (tr|Q9J2M3) Thymidylate synthetase OS=Rhesus monkey...   348   4e-93
K1VUX9_TRIAC (tr|K1VUX9) Thymidylate synthase OS=Trichosporon as...   347   5e-93
H2WFX4_CAEJA (tr|H2WFX4) Uncharacterized protein OS=Caenorhabdit...   347   6e-93
Q9WRT8_9GAMA (tr|Q9WRT8) Thymidylate synthase OS=Macaca mulatta ...   347   6e-93
Q77V82_9GAMA (tr|Q77V82) Thymidylate synthase OS=Macacine herpes...   347   6e-93
K7WWC9_9VIRU (tr|K7WWC9) Thymidylate synthase OS=White spot synd...   347   9e-93
B7P7E2_IXOSC (tr|B7P7E2) Thymidylate synthase (Fragment) OS=Ixod...   346   1e-92
G7YDA0_CLOSI (tr|G7YDA0) Thymidylate synthase OS=Clonorchis sine...   346   2e-92
H6CA25_EXODN (tr|H6CA25) Thymidylate synthase OS=Exophiala derma...   346   2e-92
Q8QTF3_WSSV (tr|Q8QTF3) WSSV124 OS=White spot syndrome virus PE=...   346   2e-92
G8JSX0_ERECY (tr|G8JSX0) Uncharacterized protein OS=Eremothecium...   345   2e-92
C5DNV0_ZYGRC (tr|C5DNV0) ZYRO0A11704p OS=Zygosaccharomyces rouxi...   345   2e-92
I2FMH7_USTH4 (tr|I2FMH7) Thymidylate synthase OS=Ustilago hordei...   345   2e-92
G0WC53_NAUDC (tr|G0WC53) Uncharacterized protein OS=Naumovozyma ...   345   3e-92
Q8JKK4_9VIRU (tr|Q8JKK4) Thymidylate synthase OS=Heliothis zea v...   345   3e-92
D3JLA5_TRYCR (tr|D3JLA5) Thymidylate synthase (Fragment) OS=Tryp...   345   3e-92
A5HEW4_WSSV (tr|A5HEW4) Putative uncharacterized protein OS=Whit...   344   5e-92
R9PBL4_9BASI (tr|R9PBL4) Phosphoglycerate mutase OS=Pseudozyma h...   344   5e-92
M9LQD7_9BASI (tr|M9LQD7) Thymidylate synthase OS=Pseudozyma anta...   344   6e-92
G9I061_9VIRU (tr|G9I061) Thymidylate synthase OS=Helicoverpa zea...   343   7e-92
G1X9J0_ARTOA (tr|G1X9J0) Uncharacterized protein OS=Arthrobotrys...   343   7e-92
O39238_9GAMA (tr|O39238) Thymidylate synthase (Fragment) OS=Rhes...   343   8e-92
F1LB10_ASCSU (tr|F1LB10) Thymidylate synthase OS=Ascaris suum PE...   343   8e-92
A7TDS8_VANPO (tr|A7TDS8) Putative uncharacterized protein OS=Van...   343   1e-91
R1GHC6_9PEZI (tr|R1GHC6) Putative thymidylate synthase protein O...   343   1e-91
C5DJN5_LACTC (tr|C5DJN5) KLTH0F17864p OS=Lachancea thermotoleran...   343   1e-91
Q6CXJ0_KLULA (tr|Q6CXJ0) KLLA0A07843p OS=Kluyveromyces lactis (s...   343   1e-91
N1JP48_ERYGR (tr|N1JP48) Thymidylate synthase OS=Blumeria gramin...   342   1e-91
J7R4G1_KAZNA (tr|J7R4G1) Thymidylate synthase OS=Kazachstania na...   342   2e-91
E7R9D5_PICAD (tr|E7R9D5) Thymidylate synthase OS=Pichia angusta ...   342   2e-91
H1VFQ0_COLHI (tr|H1VFQ0) Thymidylate synthase OS=Colletotrichum ...   342   2e-91
N1P314_YEASX (tr|N1P314) Cdc21p OS=Saccharomyces cerevisiae CEN....   342   2e-91
G2WMV2_YEASK (tr|G2WMV2) K7_Cdc21p OS=Saccharomyces cerevisiae (...   342   2e-91
E7QL68_YEASZ (tr|E7QL68) Cdc21p OS=Saccharomyces cerevisiae (str...   342   2e-91
C7GT41_YEAS2 (tr|C7GT41) Cdc21p OS=Saccharomyces cerevisiae (str...   342   2e-91
B3LJC3_YEAS1 (tr|B3LJC3) Thymidylate synthase OS=Saccharomyces c...   342   2e-91
E7M0H1_YEASV (tr|E7M0H1) Cdc21p OS=Saccharomyces cerevisiae (str...   342   2e-91
E7KUB5_YEASL (tr|E7KUB5) Cdc21p OS=Saccharomyces cerevisiae (str...   342   2e-91
Q9YVK4_MSEPV (tr|Q9YVK4) ORF MSV238 putative thymidylate synthas...   342   2e-91
E7KIF9_YEASA (tr|E7KIF9) Cdc21p OS=Saccharomyces cerevisiae (str...   342   2e-91
G3ALR6_SPAPN (tr|G3ALR6) Thymidylate synthase OS=Spathaspora pas...   342   3e-91
E7Q9J4_YEASB (tr|E7Q9J4) Cdc21p OS=Saccharomyces cerevisiae (str...   342   3e-91
E7NMX7_YEASO (tr|E7NMX7) Cdc21p OS=Saccharomyces cerevisiae (str...   342   3e-91
C8ZI35_YEAS8 (tr|C8ZI35) Cdc21p OS=Saccharomyces cerevisiae (str...   342   3e-91
H0GNK1_9SACH (tr|H0GNK1) Cdc21p OS=Saccharomyces cerevisiae x Sa...   342   3e-91
G8ZP30_TORDC (tr|G8ZP30) Uncharacterized protein OS=Torulaspora ...   341   4e-91
A3GG41_PICST (tr|A3GG41) Thymidylate synthase OS=Scheffersomyces...   341   4e-91
I2H445_TETBL (tr|I2H445) Thymidylate synthase OS=Tetrapisispora ...   341   5e-91
G0VHP3_NAUCC (tr|G0VHP3) Uncharacterized protein OS=Naumovozyma ...   341   5e-91
C4R672_PICPG (tr|C4R672) Thymidylate synthase, required for de n...   341   5e-91
G8BCL7_CANPC (tr|G8BCL7) Putative uncharacterized protein OS=Can...   340   6e-91
C5M729_CANTT (tr|C5M729) Thymidylate synthase OS=Candida tropica...   340   7e-91
D2CLW4_9APIC (tr|D2CLW4) Dihydrofolate reductase-thymidylate syn...   340   8e-91
E3QV26_COLGM (tr|E3QV26) Thymidylate synthase OS=Colletotrichum ...   340   8e-91
C8VB77_EMENI (tr|C8VB77) Putative uncharacterized protein OS=Eme...   340   8e-91
D2CLW6_9APIC (tr|D2CLW6) Dihydrofolate reductase-thymidylate syn...   340   8e-91
D2CLW7_9APIC (tr|D2CLW7) Dihydrofolate reductase-thymidylate syn...   340   9e-91
E2CT70_9APIC (tr|E2CT70) Dihydrofolate reductase-thymidylate syn...   340   1e-90
Q5AXF2_EMENI (tr|Q5AXF2) Putative uncharacterized protein OS=Eme...   340   1e-90
Q0Z9A6_CANGB (tr|Q0Z9A6) Thymidylate synthase OS=Candida glabrat...   339   1e-90
R7Z2E6_9EURO (tr|R7Z2E6) Thymidylate synthase OS=Coniosporium ap...   339   1e-90
Q9Y052_CAEEL (tr|Q9Y052) Thymidylate synthase OS=Caenorhabditis ...   339   1e-90
I8TTS3_ASPO3 (tr|I8TTS3) Thymidylate synthase OS=Aspergillus ory...   339   1e-90
Q9N588_CAEEL (tr|Q9N588) Protein Y110A7A.4 OS=Caenorhabditis ele...   339   2e-90
M3K679_CANMA (tr|M3K679) Thymidylate synthase OS=Candida maltosa...   339   2e-90
B5RT83_DEBHA (tr|B5RT83) DEHA2C06094p OS=Debaryomyces hansenii (...   339   2e-90
F9F721_FUSOF (tr|F9F721) Uncharacterized protein OS=Fusarium oxy...   339   2e-90
B6QAM1_PENMQ (tr|B6QAM1) Thymidylate synthase OS=Penicillium mar...   339   2e-90
N4TTA3_FUSOX (tr|N4TTA3) Thymidylate synthase OS=Fusarium oxyspo...   338   2e-90
Q2PIT9_ASPOR (tr|Q2PIT9) Thymidylate synthase OS=Aspergillus ory...   338   2e-90
B8NYX8_ASPFN (tr|B8NYX8) Thymidylate synthase OS=Aspergillus fla...   338   2e-90
K0KM57_WICCF (tr|K0KM57) Thymidylate synthase OS=Wickerhamomyces...   338   3e-90
D2CLY0_9APIC (tr|D2CLY0) Bifunctional dihydrofolate reductase-th...   338   3e-90
M3APN0_9PEZI (tr|M3APN0) Thymidylate synthase OS=Pseudocercospor...   338   3e-90
F2QUR8_PICP7 (tr|F2QUR8) Thymidylate synthase OS=Komagataella pa...   338   3e-90
D2CLY1_9APIC (tr|D2CLY1) Bifunctional dihydrofolate reductase-th...   338   3e-90
N4VIE9_COLOR (tr|N4VIE9) Thymidylate synthase OS=Colletotrichum ...   338   5e-90
N1QJU7_9PEZI (tr|N1QJU7) Bifunctional dihydrofolate reductase-th...   337   5e-90
G9MIP2_HYPVG (tr|G9MIP2) Uncharacterized protein OS=Hypocrea vir...   337   5e-90
G4TLH0_PIRID (tr|G4TLH0) Related to thymidylate synthase OS=Piri...   337   5e-90
Q4PBV6_USTMA (tr|Q4PBV6) Putative uncharacterized protein OS=Ust...   337   6e-90
N1PJS9_MYCPJ (tr|N1PJS9) Thymidylate synthase-like protein OS=Do...   337   6e-90
E5CYD8_PLAKN (tr|E5CYD8) Dihydrofolate reductase-thymidylate syn...   337   8e-90
C9SFX8_VERA1 (tr|C9SFX8) Bifunctional dihydrofolate reductase-th...   337   8e-90
D2CLX8_9APIC (tr|D2CLX8) Bifunctional dihydrofolate reductase-th...   337   9e-90
N1RAA8_FUSOX (tr|N1RAA8) Thymidylate synthase OS=Fusarium oxyspo...   337   9e-90
J9MBW3_FUSO4 (tr|J9MBW3) Thymidylate synthase OS=Fusarium oxyspo...   337   9e-90
D2CLX9_9APIC (tr|D2CLX9) Bifunctional dihydrofolate reductase-th...   337   9e-90
D2CLW9_9APIC (tr|D2CLW9) Dihydrofolate reductase-thymidylate syn...   337   9e-90
E4ZHS8_LEPMJ (tr|E4ZHS8) Similar to thymidylate synthase OS=Lept...   337   1e-89
E5CYD7_PLAKN (tr|E5CYD7) Dihydrofolate reductase-thymidylate syn...   337   1e-89
B3L1J6_PLAKH (tr|B3L1J6) Bifunctional dihydrofolate reductase-th...   337   1e-89
F9XB68_MYCGM (tr|F9XB68) Uncharacterized protein OS=Mycosphaerel...   337   1e-89
D2CLX1_9APIC (tr|D2CLX1) Bifunctional dihydrofolate reductase-th...   337   1e-89
G0RNK4_HYPJQ (tr|G0RNK4) Predicted protein OS=Hypocrea jecorina ...   336   1e-89
R0K654_SETTU (tr|R0K654) Uncharacterized protein OS=Setosphaeria...   336   2e-89
K3VXL5_FUSPC (tr|K3VXL5) Thymidylate synthase OS=Fusarium pseudo...   336   2e-89
D2CLW8_9APIC (tr|D2CLW8) Dihydrofolate reductase-thymidylate syn...   336   2e-89
D2CLX4_9APIC (tr|D2CLX4) Bifunctional dihydrofolate reductase-th...   335   2e-89
B9WBH8_CANDC (tr|B9WBH8) Thymidylate synthase, putative OS=Candi...   335   2e-89
H8WY31_CANO9 (tr|H8WY31) Cdc21 thymidylate synthase OS=Candida o...   335   2e-89
D2CLX0_9APIC (tr|D2CLX0) Bifunctional dihydrofolate reductase-th...   335   2e-89
D2CLX2_9APIC (tr|D2CLX2) Bifunctional dihydrofolate reductase-th...   335   2e-89
D2CLX3_9APIC (tr|D2CLX3) Bifunctional dihydrofolate reductase-th...   335   2e-89
D2CLX7_9APIC (tr|D2CLX7) Bifunctional dihydrofolate reductase-th...   335   3e-89
D2CLX5_9APIC (tr|D2CLX5) Bifunctional dihydrofolate reductase-th...   335   3e-89
C4YIJ5_CANAW (tr|C4YIJ5) Thymidylate synthase OS=Candida albican...   335   3e-89
G9PBU2_HYPAI (tr|G9PBU2) Putative uncharacterized protein OS=Hyp...   335   4e-89
G2QJ42_THIHA (tr|G2QJ42) Uncharacterized protein OS=Thielavia he...   334   4e-89
H3EFC1_PRIPA (tr|H3EFC1) Uncharacterized protein OS=Pristionchus...   334   5e-89
C4JH67_UNCRE (tr|C4JH67) Thymidylate synthase OS=Uncinocarpus re...   334   5e-89
C7YGS3_NECH7 (tr|C7YGS3) Predicted protein OS=Nectria haematococ...   334   6e-89
G2XIB3_VERDV (tr|G2XIB3) Thymidylate synthase OS=Verticillium da...   334   6e-89
Q759Q4_ASHGO (tr|Q759Q4) ADR219Cp OS=Ashbya gossypii (strain ATC...   334   7e-89
M9N4A1_ASHGS (tr|M9N4A1) FADR219Cp OS=Ashbya gossypii FDAG1 GN=F...   334   7e-89
Q6QCP2_HHV3 (tr|Q6QCP2) Thymidylate synthase OS=Human herpesviru...   333   7e-89
E4V651_ARTGP (tr|E4V651) Thymidylate synthase OS=Arthroderma gyp...   333   7e-89
D4DHD9_TRIVH (tr|D4DHD9) Putative uncharacterized protein OS=Tri...   333   7e-89
D4B532_ARTBC (tr|D4B532) Putative uncharacterized protein OS=Art...   333   7e-89
E9DSD4_METAQ (tr|E9DSD4) Thymidylate synthase OS=Metarhizium acr...   333   8e-89
A8XXD3_CAEBR (tr|A8XXD3) Protein CBG20269 OS=Caenorhabditis brig...   333   9e-89
E9F4S7_METAR (tr|E9F4S7) Thymidylate synthase OS=Metarhizium ani...   333   1e-88
D2CLX6_9APIC (tr|D2CLX6) Bifunctional dihydrofolate reductase-th...   333   1e-88
G0MF72_CAEBE (tr|G0MF72) Putative uncharacterized protein OS=Cae...   333   1e-88
H3B9E7_LATCH (tr|H3B9E7) Uncharacterized protein (Fragment) OS=L...   333   1e-88
F0XUK4_GROCL (tr|F0XUK4) Thymidylate synthase OS=Grosmannia clav...   332   2e-88
J0HFH6_COCIM (tr|J0HFH6) Thymidylate synthase OS=Coccidioides im...   332   2e-88
E9D6V5_COCPS (tr|E9D6V5) Thymidylate synthase OS=Coccidioides po...   332   2e-88
C5P3V9_COCP7 (tr|C5P3V9) Thymidylate synthase, putative OS=Cocci...   332   2e-88
B8LZ81_TALSN (tr|B8LZ81) Thymidylate synthase OS=Talaromyces sti...   332   2e-88
G8Z1X8_PLAKN (tr|G8Z1X8) Dihydrofolate reductase-thymidylate syn...   332   2e-88
L7ITX4_MAGOR (tr|L7ITX4) Thymidylate synthase OS=Magnaporthe ory...   332   3e-88
L7HVB0_MAGOR (tr|L7HVB0) Thymidylate synthase OS=Magnaporthe ory...   332   3e-88
G4MSD5_MAGO7 (tr|G4MSD5) Thymidylate synthase OS=Magnaporthe ory...   332   3e-88
F2ST54_TRIRC (tr|F2ST54) Thymidylate synthase OS=Trichophyton ru...   331   4e-88
F0URV8_AJEC8 (tr|F0URV8) Thymidylate synthase OS=Ajellomyces cap...   331   4e-88
A5DTE4_LODEL (tr|A5DTE4) Thymidylate synthase OS=Lodderomyces el...   331   4e-88
A2R2F6_ASPNC (tr|A2R2F6) Catalytic activity: 5 OS=Aspergillus ni...   331   4e-88
E3RLN4_PYRTT (tr|E3RLN4) Putative uncharacterized protein OS=Pyr...   331   5e-88
I6ZS91_ENCRO (tr|I6ZS91) Thymidylate synthase OS=Encephalitozoon...   331   5e-88
L8WXB2_9HOMO (tr|L8WXB2) Thymidylate synthase OS=Rhizoctonia sol...   330   6e-88
A8PSN6_BRUMA (tr|A8PSN6) Thymidylate synthase, putative OS=Brugi...   330   7e-88
G3XNB0_ASPNA (tr|G3XNB0) Putative uncharacterized protein OS=Asp...   330   7e-88
G7E3K6_MIXOS (tr|G7E3K6) Uncharacterized protein OS=Mixia osmund...   330   1e-87
L9KM16_TUPCH (tr|L9KM16) Thymidylate synthase OS=Tupaia chinensi...   330   1e-87
R4X6X0_9ASCO (tr|R4X6X0) Thymidylate synthase OS=Taphrina deform...   330   1e-87
B2WMW5_PYRTR (tr|B2WMW5) Bifunctional dihydrofolate reductase-th...   329   1e-87
A1D9J9_NEOFI (tr|A1D9J9) Thymidylate synthase OS=Neosartorya fis...   329   2e-87
C5FFM4_ARTOC (tr|C5FFM4) Thymidylate synthase OS=Arthroderma ota...   329   2e-87
R8BVF3_9PEZI (tr|R8BVF3) Putative thymidylate synthase protein O...   329   2e-87
A7ET01_SCLS1 (tr|A7ET01) Putative uncharacterized protein OS=Scl...   328   2e-87
G3B0C1_CANTC (tr|G3B0C1) Putative uncharacterized protein OS=Can...   328   3e-87
B6H3G1_PENCW (tr|B6H3G1) Pc13g06460 protein OS=Penicillium chrys...   328   3e-87
Q6CCB3_YARLI (tr|Q6CCB3) YALI0C10901p OS=Yarrowia lipolytica (st...   328   4e-87
G7XK11_ASPKW (tr|G7XK11) Thymidylate synthase OS=Aspergillus kaw...   328   4e-87
C0NVN1_AJECG (tr|C0NVN1) Thymidylate synthase OS=Ajellomyces cap...   327   5e-87
F2TGW6_AJEDA (tr|F2TGW6) Thymidylate synthase OS=Ajellomyces der...   327   6e-87
C5JX90_AJEDS (tr|C5JX90) Thymidylate synthase OS=Ajellomyces der...   327   6e-87
C5GRQ7_AJEDR (tr|C5GRQ7) Thymidylate synthase OS=Ajellomyces der...   327   6e-87
N4X6P1_COCHE (tr|N4X6P1) Uncharacterized protein OS=Bipolaris ma...   327   8e-87
M2SS83_COCHE (tr|M2SS83) Thymidylate synthase OS=Bipolaris maydi...   327   8e-87
C4XY75_CLAL4 (tr|C4XY75) Thymidylate synthase OS=Clavispora lusi...   327   9e-87
C1HCV6_PARBA (tr|C1HCV6) Thymidylate synthase OS=Paracoccidioide...   327   1e-86
G2YK90_BOTF4 (tr|G2YK90) Similar to thymidylate synthase OS=Botr...   327   1e-86
M7U2K5_BOTFU (tr|M7U2K5) Putative thymidylate synthase protein O...   327   1e-86
Q4W9N9_ASPFU (tr|Q4W9N9) Thymidylate synthase OS=Neosartorya fum...   326   2e-86
B0YED1_ASPFC (tr|B0YED1) Thymidylate synthase OS=Neosartorya fum...   326   2e-86
A1C942_ASPCL (tr|A1C942) Thymidylate synthase OS=Aspergillus cla...   325   2e-86
G3JCE9_CORMM (tr|G3JCE9) Thymidylate synthase OS=Cordyceps milit...   325   2e-86
F8PFC1_SERL3 (tr|F8PFC1) Putative uncharacterized protein OS=Ser...   325   3e-86
F8ND82_SERL9 (tr|F8ND82) Putative uncharacterized protein OS=Ser...   325   3e-86
F2S892_TRIT1 (tr|F2S892) Thymidylate synthase OS=Trichophyton to...   325   3e-86

>I1K753_SOYBN (tr|I1K753) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 530

 Score =  898 bits (2320), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 424/523 (81%), Positives = 459/523 (87%)

Query: 2   MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 61
           M  DS V+          PLPNLQRTYQVVVAAT+D GIGKDGKLPWRL TDLKFFKEIT
Sbjct: 1   MPSDSSVISNGHSNGSVNPLPNLQRTYQVVVAATQDWGIGKDGKLPWRLPTDLKFFKEIT 60

Query: 62  TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 121
             TSDPGKKNAIVMGRKTWESIPL+YRPL GRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 61  MKTSDPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSSA 120

Query: 122 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 181
                  PY LSIEKVFVIGGGQIFRE LN PGCEAIH TEI +SIECDTFMPPVD T +
Sbjct: 121 LELLAASPYSLSIEKVFVIGGGQIFREALNVPGCEAIHLTEIQSSIECDTFMPPVDFTIF 180

Query: 182 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
           + WYSSFPKVEN+IRYSF TYVRV+SSAAES  QN DPL DNNS+S+KFEV++F FLP+M
Sbjct: 181 RPWYSSFPKVENNIRYSFTTYVRVRSSAAESAGQNIDPLLDNNSESMKFEVKDFSFLPKM 240

Query: 242 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRG 301
           I +RHEEY+YL+L+Q+II+E            LSKFGCQMRFNLR +FPLLTTKKVFWRG
Sbjct: 241 ISERHEEYLYLKLVQDIIAEGTTKGDRTGTGTLSKFGCQMRFNLRGNFPLLTTKKVFWRG 300

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD +GLTEREEGDLGPVYGFQWRHFG
Sbjct: 301 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGVGLTEREEGDLGPVYGFQWRHFG 360

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           ARY+DMH DYSGQG+DQLLDVINKIK NP+DRRIILSAWNPVDLKLMALPPCHMFAQF+V
Sbjct: 361 ARYTDMHHDYSGQGFDQLLDVINKIKRNPDDRRIILSAWNPVDLKLMALPPCHMFAQFYV 420

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           A+GELSCQMYQRSADMGLG+PFNIASYALLTCMIAHVC+L+PGDF+HVIGDAH+Y NHVR
Sbjct: 421 AHGELSCQMYQRSADMGLGIPFNIASYALLTCMIAHVCDLIPGDFIHVIGDAHIYRNHVR 480

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PLQEQL N PKPFPTLKIN +KKDIDSFVAADFKL+GY+PHQK
Sbjct: 481 PLQEQLHNQPKPFPTLKINPKKKDIDSFVAADFKLIGYDPHQK 523


>I1K754_SOYBN (tr|I1K754) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 568

 Score =  897 bits (2318), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 424/524 (80%), Positives = 460/524 (87%)

Query: 1   MMTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEI 60
           +M  DS V+          PLPNLQRTYQVVVAAT+D GIGKDGKLPWRL TDLKFFKEI
Sbjct: 38  IMPSDSSVISNGHSNGSVNPLPNLQRTYQVVVAATQDWGIGKDGKLPWRLPTDLKFFKEI 97

Query: 61  TTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXX 120
           T  TSDPGKKNAIVMGRKTWESIPL+YRPL GRLNVVLTRSGSFDI TAENVVICGS+  
Sbjct: 98  TMKTSDPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSS 157

Query: 121 XXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTK 180
                   PY LSIEKVFVIGGGQIFRE LN PGCEAIH TEI +SIECDTFMPPVD T 
Sbjct: 158 ALELLAASPYSLSIEKVFVIGGGQIFREALNVPGCEAIHLTEIQSSIECDTFMPPVDFTI 217

Query: 181 YQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPE 240
           ++ WYSSFPKVEN+IRYSF TYVRV+SSAAES  QN DPL DNNS+S+KFEV++F FLP+
Sbjct: 218 FRPWYSSFPKVENNIRYSFTTYVRVRSSAAESAGQNIDPLLDNNSESMKFEVKDFSFLPK 277

Query: 241 MILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWR 300
           MI +RHEEY+YL+L+Q+II+E            LSKFGCQMRFNLR +FPLLTTKKVFWR
Sbjct: 278 MISERHEEYLYLKLVQDIIAEGTTKGDRTGTGTLSKFGCQMRFNLRGNFPLLTTKKVFWR 337

Query: 301 GVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHF 360
           GVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD +GLTEREEGDLGPVYGFQWRHF
Sbjct: 338 GVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGVGLTEREEGDLGPVYGFQWRHF 397

Query: 361 GARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFF 420
           GARY+DMH DYSGQG+DQLLDVINKIK NP+DRRIILSAWNPVDLKLMALPPCHMFAQF+
Sbjct: 398 GARYTDMHHDYSGQGFDQLLDVINKIKRNPDDRRIILSAWNPVDLKLMALPPCHMFAQFY 457

Query: 421 VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHV 480
           VA+GELSCQMYQRSADMGLG+PFNIASYALLTCMIAHVC+L+PGDF+HVIGDAH+Y NHV
Sbjct: 458 VAHGELSCQMYQRSADMGLGIPFNIASYALLTCMIAHVCDLIPGDFIHVIGDAHIYRNHV 517

Query: 481 RPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           RPLQEQL N PKPFPTLKIN +KKDIDSFVAADFKL+GY+PHQK
Sbjct: 518 RPLQEQLHNQPKPFPTLKINPKKKDIDSFVAADFKLIGYDPHQK 561


>K7KHI6_SOYBN (tr|K7KHI6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 530

 Score =  884 bits (2284), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 419/523 (80%), Positives = 455/523 (86%)

Query: 2   MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 61
           M GDS V+          PL NL+RTYQV+VAAT+D GIGKDGKLPWRL TDLKFFK+IT
Sbjct: 1   MAGDSSVMSNGYSKGSVNPLTNLRRTYQVLVAATQDWGIGKDGKLPWRLPTDLKFFKDIT 60

Query: 62  TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 121
             TSDPGKKNAIVMGRKTWESIPL+YRPL GRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 61  VKTSDPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSSA 120

Query: 122 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 181
                  PY LSIEKVFVIGGGQIFRE LNAPGCEAIH TEI +SIECDTFMPPVD T +
Sbjct: 121 LELLAASPYSLSIEKVFVIGGGQIFREALNAPGCEAIHLTEIQSSIECDTFMPPVDFTMF 180

Query: 182 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
           + WYSSFPKVEN+IRY F TYVRV+SSA ES  QN D L DNNS+S+KFEV+ F FLP+M
Sbjct: 181 RPWYSSFPKVENNIRYCFTTYVRVRSSAPESPGQNIDQLLDNNSESMKFEVKEFSFLPKM 240

Query: 242 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRG 301
           I +RHEEY+YL+L+Q+II+E            LSKFGCQMRFNL  SFPLLTTK+VFWRG
Sbjct: 241 ISERHEEYLYLKLVQDIIAEGTTKDDRTGTGTLSKFGCQMRFNLHGSFPLLTTKRVFWRG 300

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD +GLTEREEGDLGPVYGFQWRHFG
Sbjct: 301 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGVGLTEREEGDLGPVYGFQWRHFG 360

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           ARY+DMH DYSGQG+DQLLDVINKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+V
Sbjct: 361 ARYTDMHHDYSGQGFDQLLDVINKIKHNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYV 420

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           A+GELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC+L+PGDF+HVIGDAHVY NHVR
Sbjct: 421 AHGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCDLIPGDFIHVIGDAHVYCNHVR 480

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PLQEQL N PKPFPTL+IN +KKDIDSFVAADFKL+GY+PHQK
Sbjct: 481 PLQEQLHNQPKPFPTLEINPKKKDIDSFVAADFKLIGYDPHQK 523


>Q8L6F0_PEA (tr|Q8L6F0) Dihydrofolate reductase-thymidylate synthase OS=Pisum
           sativum GN=dhfrts1 PE=2 SV=1
          Length = 530

 Score =  871 bits (2251), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 410/523 (78%), Positives = 446/523 (85%)

Query: 2   MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 61
           M  DS V+          P+PNLQRTYQVVVAATKDMGIGKDGKLPWRL TDLKFFKE+T
Sbjct: 1   MAADSSVMFNGNGNGSINPMPNLQRTYQVVVAATKDMGIGKDGKLPWRLPTDLKFFKELT 60

Query: 62  TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 121
           T T + GKKNAIVMGRKTWESIPL++RPLPGRLNVVLTRSGSFD   AENVVICGS+   
Sbjct: 61  TTTFETGKKNAIVMGRKTWESIPLQFRPLPGRLNVVLTRSGSFDAKAAENVVICGSMSSA 120

Query: 122 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 181
                  PYC SIEK+FVIGGG+IFR+ LN P CEAIH TEIH S ECDTFMPP+D T +
Sbjct: 121 LELLAASPYCTSIEKIFVIGGGEIFRDALNVPECEAIHITEIHTSFECDTFMPPIDFTTF 180

Query: 182 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
           + WYSSFPKVEN+IRYSF TYVRV+SS AESL+Q+T    DN   S KFEVQNF FLP+M
Sbjct: 181 RPWYSSFPKVENNIRYSFTTYVRVRSSVAESLNQSTVSPLDNKPASKKFEVQNFSFLPKM 240

Query: 242 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRG 301
           I +RHEEYMYL L+QEIIS+            LSKFGCQMRFNLRR FPLLTTK+VFWRG
Sbjct: 241 IFERHEEYMYLNLVQEIISQGTSKGDRTGTGTLSKFGCQMRFNLRRGFPLLTTKRVFWRG 300

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           VVEELLWFISGSTNAKVLQEKGIHIWD NASRE+LDSIGL+EREEGDLGPVYGFQWRHFG
Sbjct: 301 VVEELLWFISGSTNAKVLQEKGIHIWDDNASREFLDSIGLSEREEGDLGPVYGFQWRHFG 360

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           ARY++MH DY+GQG DQLLDVINK+KHNP+DRRIILSAWNP DLKLMALPPCHM AQF+V
Sbjct: 361 ARYTNMHNDYAGQGVDQLLDVINKVKHNPDDRRIILSAWNPADLKLMALPPCHMSAQFYV 420

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           ANGELSCQM QRSADMGLGVPFNIASYALLTCMIAH+CELVPGDF+HV+GDAHVY  HVR
Sbjct: 421 ANGELSCQMNQRSADMGLGVPFNIASYALLTCMIAHICELVPGDFIHVLGDAHVYQTHVR 480

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PLQEQL NLPKPFPTLKINS+KKDIDSFVA DFKL+ Y+PHQK
Sbjct: 481 PLQEQLHNLPKPFPTLKINSKKKDIDSFVATDFKLIDYDPHQK 523


>K7LP84_SOYBN (tr|K7LP84) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Glycine max PE=3 SV=1
          Length = 618

 Score =  867 bits (2239), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 407/524 (77%), Positives = 446/524 (85%), Gaps = 2/524 (0%)

Query: 1   MMTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEI 60
           +M  DS V+          P P  QRTYQ VV AT+DMGI KD KLPW L TDL FF+EI
Sbjct: 90  IMASDSLVISNGNGNSKSEPHP--QRTYQAVVVATRDMGISKDEKLPWTLPTDLNFFEEI 147

Query: 61  TTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXX 120
           TT TSDPGKKNA+VMGRKTWESIP + RPLPGRLNVVLTRSGSFDI TAENV+ICGS+  
Sbjct: 148 TTTTSDPGKKNAVVMGRKTWESIPPENRPLPGRLNVVLTRSGSFDIATAENVLICGSVSS 207

Query: 121 XXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTK 180
                   PYCLSIEKVF+ GGG+IFRE LNAPGCEA H TEI ASIECDTFMP V+++ 
Sbjct: 208 AMELLASSPYCLSIEKVFLTGGGEIFREALNAPGCEAAHITEIEASIECDTFMPRVNTSV 267

Query: 181 YQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPE 240
           +Q WYSSFP VE+++RYSF TYVRV+S   ES  QN DP FDNNSD+LKFEV+ F FLP+
Sbjct: 268 FQTWYSSFPLVEDNLRYSFTTYVRVRSFPPESPDQNADPFFDNNSDALKFEVKKFSFLPK 327

Query: 241 MILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWR 300
           M+ +RHEE+ YLRL+QEIISE            LSKFGCQMRFNLRR+FPLLTTKKVFWR
Sbjct: 328 MVYERHEEFKYLRLVQEIISEGTTKDDRTGTGTLSKFGCQMRFNLRRNFPLLTTKKVFWR 387

Query: 301 GVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHF 360
           GV+EELLWFISGST+AKVLQEKGIHIWDGNASREYLDSIGLT+REEGDLGPVYGFQWRHF
Sbjct: 388 GVIEELLWFISGSTSAKVLQEKGIHIWDGNASREYLDSIGLTDREEGDLGPVYGFQWRHF 447

Query: 361 GARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFF 420
           GA+Y+DMH DYSGQG+DQLLDVINKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+
Sbjct: 448 GAKYTDMHADYSGQGFDQLLDVINKIKHNPDDRRIILSAWNPSDLKLMALPPCHMFAQFY 507

Query: 421 VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHV 480
           VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC+LVPGDF+HVIGDAHVY NHV
Sbjct: 508 VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCDLVPGDFIHVIGDAHVYRNHV 567

Query: 481 RPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           RPLQEQL N PKPFP LKIN +KKDIDSFVA+DFKL+GY PHQK
Sbjct: 568 RPLQEQLQNQPKPFPILKINPKKKDIDSFVASDFKLIGYVPHQK 611


>I1LQ11_SOYBN (tr|I1LQ11) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=2
          Length = 530

 Score =  863 bits (2231), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 404/500 (80%), Positives = 437/500 (87%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QRTYQVVV AT+DMGI KD KLPW L T+LKFF+EITT TSDPGKKNA+VMGRKTWESIP
Sbjct: 24  QRTYQVVVVATRDMGISKDAKLPWTLPTELKFFEEITTTTSDPGKKNAVVMGRKTWESIP 83

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
            + RPLPGRLNVVLTRSGSFDI TAENV+ICGS+          PYCLSIEKVF+ GGG+
Sbjct: 84  PENRPLPGRLNVVLTRSGSFDIATAENVLICGSMASAMELLASSPYCLSIEKVFLTGGGE 143

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           IFRE LNAPGCEA H TEI ASIECDTFMP VD+  +Q WYSSFP VE+++RYSF TY R
Sbjct: 144 IFREALNAPGCEAAHITEIEASIECDTFMPRVDTNVFQTWYSSFPLVEDNLRYSFTTYAR 203

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+SS  E L QN DP F NNSDS KFEV+ F FLP+M+ +RHEE+ YLRL+QEIISE   
Sbjct: 204 VRSSPPEFLDQNADPFFYNNSDSFKFEVKKFSFLPKMVYERHEEFKYLRLVQEIISEGTT 263

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLRR+FPLLTTKKVFWRGVVEELLWFISGST+AK LQEKGI
Sbjct: 264 KDDRTGTGTLSKFGCQMRFNLRRNFPLLTTKKVFWRGVVEELLWFISGSTSAKALQEKGI 323

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDSIGLTERE+GDLGPVYGFQWRHFGA+Y+DMH DYSGQG+DQLLDVIN
Sbjct: 324 HIWDGNASREYLDSIGLTEREKGDLGPVYGFQWRHFGAKYTDMHADYSGQGFDQLLDVIN 383

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIKHNPNDRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVPFN
Sbjct: 384 KIKHNPNDRRIILSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFN 443

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASYALLTCMIAHVC+LVPGDF+HVIGDAHVY NHVRPLQEQL N PKPFP LKIN +KK
Sbjct: 444 IASYALLTCMIAHVCDLVPGDFIHVIGDAHVYRNHVRPLQEQLQNQPKPFPILKINPKKK 503

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSFVAADFKL+GY+PHQK
Sbjct: 504 DIDSFVAADFKLIGYDPHQK 523


>G7J766_MEDTR (tr|G7J766) Dihydrofolate reductase-thymidylate synthase
           OS=Medicago truncatula GN=MTR_3g117080 PE=3 SV=1
          Length = 558

 Score =  855 bits (2208), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 403/502 (80%), Positives = 439/502 (87%), Gaps = 1/502 (0%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           NLQRTYQVVVAATK+MGIGKDGKLPWRL TDLKFFKEITT TS+PGKKNAIVMGRKTWES
Sbjct: 51  NLQRTYQVVVAATKEMGIGKDGKLPWRLPTDLKFFKEITTTTSEPGKKNAIVMGRKTWES 110

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IPL++RPL GRLNVVLTRSG+FDI  AENVVIC S+          PY  SIEK+FVIGG
Sbjct: 111 IPLQFRPLLGRLNVVLTRSGTFDIAAAENVVICRSMSSALELLAASPYHTSIEKIFVIGG 170

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           G+IFRE LNAP CEAIH TEI ++IECDTFMPP+D+T +Q WYSSF KVEN+IRYSF TY
Sbjct: 171 GEIFREALNAPECEAIHLTEIQSNIECDTFMPPIDTTIFQPWYSSFTKVENNIRYSFTTY 230

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+SSAAE   +NTD  FD+NS S KFEVQNF FLP+MI +RH EYMYL L+QEIIS+ 
Sbjct: 231 VRVRSSAAE-YPKNTDSFFDSNSASKKFEVQNFSFLPKMIFERHAEYMYLNLVQEIISQG 289

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      LS FGCQMRFNLRR FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQ+K
Sbjct: 290 TTKGDRTGTGTLSAFGCQMRFNLRRGFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQQK 349

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GIHIWD NASRE+LDSIGL+EREEGDLGPVYGFQWRHFGA+Y++MH DY+ QG DQLLDV
Sbjct: 350 GIHIWDDNASREFLDSIGLSEREEGDLGPVYGFQWRHFGAKYTNMHGDYANQGLDQLLDV 409

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVP
Sbjct: 410 INKIKHNPDDRRIILSAWNPADLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVP 469

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASYALLTCMIAH+CELVPGDF+H IGDAHVY  HVRPLQEQL NLPKPFPTLKIN +
Sbjct: 470 FNIASYALLTCMIAHICELVPGDFIHAIGDAHVYQTHVRPLQEQLHNLPKPFPTLKINPK 529

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFVA DFKL+ Y+PHQK
Sbjct: 530 KKDIDSFVATDFKLIDYDPHQK 551


>G7J765_MEDTR (tr|G7J765) Dihydrofolate reductase-thymidylate synthase
           OS=Medicago truncatula GN=MTR_3g117080 PE=3 SV=1
          Length = 569

 Score =  855 bits (2208), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 403/502 (80%), Positives = 439/502 (87%), Gaps = 1/502 (0%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           NLQRTYQVVVAATK+MGIGKDGKLPWRL TDLKFFKEITT TS+PGKKNAIVMGRKTWES
Sbjct: 62  NLQRTYQVVVAATKEMGIGKDGKLPWRLPTDLKFFKEITTTTSEPGKKNAIVMGRKTWES 121

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IPL++RPL GRLNVVLTRSG+FDI  AENVVIC S+          PY  SIEK+FVIGG
Sbjct: 122 IPLQFRPLLGRLNVVLTRSGTFDIAAAENVVICRSMSSALELLAASPYHTSIEKIFVIGG 181

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           G+IFRE LNAP CEAIH TEI ++IECDTFMPP+D+T +Q WYSSF KVEN+IRYSF TY
Sbjct: 182 GEIFREALNAPECEAIHLTEIQSNIECDTFMPPIDTTIFQPWYSSFTKVENNIRYSFTTY 241

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+SSAAE   +NTD  FD+NS S KFEVQNF FLP+MI +RH EYMYL L+QEIIS+ 
Sbjct: 242 VRVRSSAAE-YPKNTDSFFDSNSASKKFEVQNFSFLPKMIFERHAEYMYLNLVQEIISQG 300

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      LS FGCQMRFNLRR FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQ+K
Sbjct: 301 TTKGDRTGTGTLSAFGCQMRFNLRRGFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQQK 360

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GIHIWD NASRE+LDSIGL+EREEGDLGPVYGFQWRHFGA+Y++MH DY+ QG DQLLDV
Sbjct: 361 GIHIWDDNASREFLDSIGLSEREEGDLGPVYGFQWRHFGAKYTNMHGDYANQGLDQLLDV 420

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVP
Sbjct: 421 INKIKHNPDDRRIILSAWNPADLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVP 480

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASYALLTCMIAH+CELVPGDF+H IGDAHVY  HVRPLQEQL NLPKPFPTLKIN +
Sbjct: 481 FNIASYALLTCMIAHICELVPGDFIHAIGDAHVYQTHVRPLQEQLHNLPKPFPTLKINPK 540

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFVA DFKL+ Y+PHQK
Sbjct: 541 KKDIDSFVATDFKLIDYDPHQK 562


>K7LSY4_SOYBN (tr|K7LSY4) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 580

 Score =  848 bits (2192), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 402/524 (76%), Positives = 440/524 (83%), Gaps = 4/524 (0%)

Query: 1   MMTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEI 60
           +M  D+ V+             + QRTYQVVV AT+DMGI KD KLPW L T+LKFF+EI
Sbjct: 54  IMATDALVISNGNGNGNAKSELHPQRTYQVVVVATRDMGISKDAKLPWTLPTELKFFEEI 113

Query: 61  TTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXX 120
           TT TSDPGKKNA+VMGRKTWESIP + RPLPGRLNVVLTRSGSFDI TAENV+ICGS+  
Sbjct: 114 TTTTSDPGKKNAVVMGRKTWESIPPENRPLPGRLNVVLTRSGSFDIATAENVLICGSMAS 173

Query: 121 XXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTK 180
                   PYCLSIEKVF+ GGG+IFRE LNAPGCEA H TEI ASIECDTFMP VD+  
Sbjct: 174 AMELLASSPYCLSIEKVFLTGGGEIFREALNAPGCEAAHITEIEASIECDTFMPRVDTNV 233

Query: 181 YQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPE 240
           +Q WYSSFP VE+++RYSF TY RV+SS  E L QN DP F NNSDS KFEV+ F FLP+
Sbjct: 234 FQTWYSSFPLVEDNLRYSFTTYARVRSSPPEFLDQNADPFFYNNSDSFKFEVKKFSFLPK 293

Query: 241 MILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWR 300
           M+ +RHEE+ YLRL+QEIISE            LSKFGCQMRFNLRR+FPLLTTKKVFWR
Sbjct: 294 MVYERHEEFKYLRLVQEIISEGTTKDDRTGTGTLSKFGCQMRFNLRRNFPLLTTKKVFWR 353

Query: 301 GVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHF 360
           GVVEELLWFISGST+AK LQEKGIHIWDGNASR+    IGLTERE+GDLGPVYGFQWRHF
Sbjct: 354 GVVEELLWFISGSTSAKALQEKGIHIWDGNASRD----IGLTEREKGDLGPVYGFQWRHF 409

Query: 361 GARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFF 420
           GA+Y+DMH DYSGQG+DQLLDVINKIKHNPNDRRIILSAWNP DLKLMALPPCHMFAQF+
Sbjct: 410 GAKYTDMHADYSGQGFDQLLDVINKIKHNPNDRRIILSAWNPSDLKLMALPPCHMFAQFY 469

Query: 421 VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHV 480
           VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC+LVPGDF+HVIGDAHVY NHV
Sbjct: 470 VANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCDLVPGDFIHVIGDAHVYRNHV 529

Query: 481 RPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           RPLQEQL N PKPFP LKIN +KKDIDSFVAADFKL+GY+PHQK
Sbjct: 530 RPLQEQLQNQPKPFPILKINPKKKDIDSFVAADFKLIGYDPHQK 573


>B9H0T4_POPTR (tr|B9H0T4) Dihydrofolate reductase-thymidylate synthase OS=Populus
           trichocarpa GN=DHFR-TS-1 PE=2 SV=1
          Length = 528

 Score =  847 bits (2189), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 396/523 (75%), Positives = 446/523 (85%), Gaps = 2/523 (0%)

Query: 2   MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 61
           M+GDS               P  ++TYQVVVAATKDMGIGKDGKLPW+L +DLKFFK++T
Sbjct: 1   MSGDSVANLSNGNANTQQSDP--RKTYQVVVAATKDMGIGKDGKLPWKLPSDLKFFKDLT 58

Query: 62  TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 121
             T D GKKNA++MGRKTWESIPL++RPLPGRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 59  LTTMDSGKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGSMGSA 118

Query: 122 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 181
                  PYCLSIEKVFVIGGGQI RE LNAPGC+AIH TEI    +CDTF+P +D++ +
Sbjct: 119 LELLAASPYCLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVF 178

Query: 182 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
           Q WYSSFPKVENDIR+ F TYVRV+SS  ES SQN     D NS++ KFEV+ F FLP+M
Sbjct: 179 QPWYSSFPKVENDIRHCFTTYVRVRSSTIESHSQNNGENSDGNSENSKFEVKKFSFLPKM 238

Query: 242 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRG 301
           + +RHEEY+YLR++Q+IIS+            LSKFGCQMRFNLR++FPLLTTKKVFWRG
Sbjct: 239 VFERHEEYLYLRMVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRKNFPLLTTKKVFWRG 298

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           VVEELLWFISGST+AKVLQEKGIHIWDGNASREYLDSIGL +REEGDLGPVYGFQWRHFG
Sbjct: 299 VVEELLWFISGSTSAKVLQEKGIHIWDGNASREYLDSIGLKDREEGDLGPVYGFQWRHFG 358

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           ARY+DMH DY+GQG+DQLLDVI+KIK+NPNDRRII+SAWNP DLKLMALPPCHMFAQF+V
Sbjct: 359 ARYTDMHADYTGQGFDQLLDVIDKIKNNPNDRRIIISAWNPSDLKLMALPPCHMFAQFYV 418

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           ANGELSCQMYQRSADMGLGVPFNIASYALLTC+IAHVC+L+PGDFVHVIGDAHVYH H+R
Sbjct: 419 ANGELSCQMYQRSADMGLGVPFNIASYALLTCIIAHVCDLIPGDFVHVIGDAHVYHTHIR 478

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PLQEQL  LPKPFP LKINSEKKDID+FVAADFKL+GY+PHQK
Sbjct: 479 PLQEQLRKLPKPFPILKINSEKKDIDTFVAADFKLIGYDPHQK 521


>M5VK78_PRUPE (tr|M5VK78) Uncharacterized protein OS=Prunus persica
           GN=PRUPE_ppa004093mg PE=4 SV=1
          Length = 530

 Score =  847 bits (2189), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 392/503 (77%), Positives = 442/503 (87%)

Query: 22  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 81
           PN QRTYQVVVAAT++MGIGKDGKLPWRL +DLKFFKE+T  TSDPGKKNA+VMGRKTWE
Sbjct: 21  PNPQRTYQVVVAATREMGIGKDGKLPWRLPSDLKFFKEVTVTTSDPGKKNAVVMGRKTWE 80

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           SI  ++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSI+KVF+IG
Sbjct: 81  SIAPEHRPLPGRLNVVLTRSGSFDIATAENVVICGSMASALELLAASPYCLSIDKVFIIG 140

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           GGQI RE LNAPGC+AIH TEI   IECDTF+P +DS+ +Q WYSSFPKVEN IR+SF T
Sbjct: 141 GGQILREALNAPGCDAIHITEIETDIECDTFIPAIDSSVFQPWYSSFPKVENSIRHSFTT 200

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           YVRV SSA ESL QN D +  + SDS+K EV+NF FLP+MI ++HEE++YL L++EI+S+
Sbjct: 201 YVRVSSSAVESLCQNNDLISSSKSDSVKCEVKNFSFLPKMIFEKHEEHIYLSLVREILSD 260

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       LSKFGCQMRFNLRR+FPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE
Sbjct: 261 GTSKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 320

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KGIHIWDGNASR+YLDS+GLT++EEGDLGPVYGFQWRHFGARY+DM+ DY+GQG+DQLLD
Sbjct: 321 KGIHIWDGNASRDYLDSVGLTDKEEGDLGPVYGFQWRHFGARYTDMNADYTGQGFDQLLD 380

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VI+KIK NP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSAD+GLGV
Sbjct: 381 VIDKIKINPDDRRIILSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADVGLGV 440

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASYALLTCMIAHVC+LVPGDF+HV+GDAHVY  H+RPLQEQL  LPKPFP LKIN 
Sbjct: 441 PFNIASYALLTCMIAHVCDLVPGDFIHVLGDAHVYRTHIRPLQEQLEKLPKPFPILKINP 500

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
           EKK+IDSFVAADF+L+GY+PHQK
Sbjct: 501 EKKNIDSFVAADFELIGYDPHQK 523


>B0BLI5_LOTJA (tr|B0BLI5) CM0216.390.nc protein OS=Lotus japonicus
           GN=CM0216.390.nc PE=3 SV=1
          Length = 528

 Score =  838 bits (2165), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 409/523 (78%), Positives = 444/523 (84%), Gaps = 2/523 (0%)

Query: 2   MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 61
           M  DS V+            P  QRTYQ VV AT DMGI KDGKLPW L TD KFF+EIT
Sbjct: 1   MASDSLVISNGHDNGNLELSP--QRTYQAVVIATPDMGISKDGKLPWALPTDQKFFEEIT 58

Query: 62  TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 121
           T TSDPGKKNA+VMGRK+WE+IP + RPL GRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 59  TKTSDPGKKNAVVMGRKSWEAIPPEKRPLCGRLNVVLTRSGSFDIATAENVVICGSVSSA 118

Query: 122 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 181
                  PY +SIEKVF+ GGG+IFRE LNAPGCEA+H TEI ASIECDTFMP VD + +
Sbjct: 119 MELLASSPYSMSIEKVFLTGGGEIFREALNAPGCEAVHITEIEASIECDTFMPRVDFSVF 178

Query: 182 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
             WYSSFP VEN+IRYSF TYVRV+SSA ESL QNTDP FD++SDSLKFEV+ F FLP+M
Sbjct: 179 HPWYSSFPLVENNIRYSFNTYVRVRSSAEESLGQNTDPSFDSDSDSLKFEVKKFSFLPKM 238

Query: 242 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRG 301
           I + HEEY YLRL+QEIISE            LSKFGCQMRFNLRRSFPLLTTKKVFWRG
Sbjct: 239 IFESHEEYKYLRLVQEIISEGTVKDDRTGTGTLSKFGCQMRFNLRRSFPLLTTKKVFWRG 298

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           VVEELLWFISGST+AKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG
Sbjct: 299 VVEELLWFISGSTSAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 358

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           ARY++MH DYSG+G+DQLLDVINKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+V
Sbjct: 359 ARYTNMHDDYSGKGFDQLLDVINKIKHNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYV 418

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC+LVPGDF+HVIGDAHVY NHV+
Sbjct: 419 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCDLVPGDFIHVIGDAHVYRNHVK 478

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PLQEQL NLP+PFP LKIN +KKDIDSF A DFKL+GY+PHQK
Sbjct: 479 PLQEQLQNLPRPFPILKINPKKKDIDSFEATDFKLIGYDPHQK 521


>F6I0M2_VITVI (tr|F6I0M2) Putative uncharacterized protein OS=Vitis vinifera
           GN=VIT_03s0038g04500 PE=3 SV=1
          Length = 630

 Score =  830 bits (2144), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 388/503 (77%), Positives = 435/503 (86%), Gaps = 3/503 (0%)

Query: 22  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 81
           P+ QRTYQVVVAAT+DMGIGKDGKLPWRL +D+K FK+IT   +D  KKNA++MGRKTWE
Sbjct: 124 PDPQRTYQVVVAATRDMGIGKDGKLPWRLPSDMKIFKDITMTVADTVKKNAVIMGRKTWE 183

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           SIPL++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSIEKVFVIG
Sbjct: 184 SIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGSMASALELLAASPYCLSIEKVFVIG 243

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           GGQI RE LNAPGC+AIH TEI  S ECDTF+P +DS  +Q WYSSFP VEN+IRYSF T
Sbjct: 244 GGQILREALNAPGCDAIHITEIETSFECDTFIPAIDSLVFQPWYSSFPLVENNIRYSFMT 303

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           YVRV+SSA ES  QN     D+  +S+KFEV+ F FLP+MI +RHEEY+YLRL+++IIS 
Sbjct: 304 YVRVRSSADESQIQNNG---DSGLESIKFEVKKFSFLPKMIFERHEEYIYLRLVEDIISN 360

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       LSKFGCQMRFNLR++FPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE
Sbjct: 361 GVQRDDRTGTGTLSKFGCQMRFNLRKTFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 420

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KGIHIWDGNASR+YLDSIGL +REEGDLGP+YGFQWRHFGA Y DMH DY+GQG+DQLLD
Sbjct: 421 KGIHIWDGNASRDYLDSIGLADREEGDLGPIYGFQWRHFGASYIDMHADYTGQGFDQLLD 480

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VINKIK+NPNDRRIILSAWNP DLKLMALPPCHMFAQF+V++GELSCQMYQRSADMGLGV
Sbjct: 481 VINKIKNNPNDRRIILSAWNPSDLKLMALPPCHMFAQFYVSHGELSCQMYQRSADMGLGV 540

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASYALLTCMIAHVC+LVPGDF+HVIGD+HVY  H+RPLQEQL  LPKPFP LKIN 
Sbjct: 541 PFNIASYALLTCMIAHVCDLVPGDFIHVIGDSHVYLTHIRPLQEQLQKLPKPFPILKINP 600

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
           +KK+IDSFVAADF+L+GY+PHQK
Sbjct: 601 QKKNIDSFVAADFQLIGYDPHQK 623


>G7JHF2_MEDTR (tr|G7JHF2) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Medicago truncatula GN=MTR_4g070670 PE=3
           SV=1
          Length = 528

 Score =  825 bits (2130), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 386/503 (76%), Positives = 433/503 (86%)

Query: 22  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 81
           PN QRTYQVVV AT+DMGI KDGKLPW L  D KFF++ITT TSDPGKKNA+VMGRK+WE
Sbjct: 19  PNPQRTYQVVVIATRDMGIAKDGKLPWTLPIDQKFFEDITTVTSDPGKKNAVVMGRKSWE 78

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           +IP + RPL GRLN++LTRSGSF+I TA+NV+ICGS+          PYC SIEKVF+ G
Sbjct: 79  AIPPENRPLRGRLNIILTRSGSFEIATADNVLICGSVSSAMELLASSPYCQSIEKVFLTG 138

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           G +IFRE L+APGCEAIH TEI ASIECDTFMP +D + +  WY+SFP VEN IRYSF T
Sbjct: 139 GAEIFREALHAPGCEAIHITEIEASIECDTFMPRIDFSVFHPWYTSFPLVENGIRYSFNT 198

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           YVRV+SS  ES   NTDP+  +NS+ LKFE+++F FLP++I +RHEEY YL+L++EIISE
Sbjct: 199 YVRVRSSTEESQGLNTDPVLYDNSNPLKFEIKDFTFLPKIIFERHEEYKYLKLVEEIISE 258

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       LSKFG +MRFNLRRSFPLLTTK+VFWRGVVEELLWFISGST+AKVLQE
Sbjct: 259 GTVKDDRTGTGTLSKFGSKMRFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTSAKVLQE 318

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KGIHIWDGNASREYLDSIGL EREE DLGPVYGFQWRHFGARY++MH DYSGQG+DQLLD
Sbjct: 319 KGIHIWDGNASREYLDSIGLKEREEADLGPVYGFQWRHFGARYTNMHDDYSGQGFDQLLD 378

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VINKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGV
Sbjct: 379 VINKIKHNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGV 438

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASYALLT MIAHVC+LVPGD +HVIGDAHVY NHV+PLQEQL NLPKPFP LKIN 
Sbjct: 439 PFNIASYALLTYMIAHVCDLVPGDLIHVIGDAHVYRNHVKPLQEQLQNLPKPFPILKINP 498

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
           +KKDIDSFVAADFKL+GY+PHQK
Sbjct: 499 KKKDIDSFVAADFKLIGYDPHQK 521


>B9RH79_RICCO (tr|B9RH79) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative OS=Ricinus communis GN=RCOM_1447960
           PE=3 SV=1
          Length = 528

 Score =  822 bits (2122), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 382/500 (76%), Positives = 434/500 (86%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           +RTYQVVVAAT+DMGIGKDGKLPWRL +DLKFFK++T  T+D GKKNA++MGRKTWESIP
Sbjct: 22  RRTYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKDVTLTTTDSGKKNAVIMGRKTWESIP 81

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           L++RPLPGRLNVVLTRSGSFDI TAENVV+CGS           PYCLSIEKV+VIGGGQ
Sbjct: 82  LEHRPLPGRLNVVLTRSGSFDIATAENVVMCGSFASALELLAASPYCLSIEKVYVIGGGQ 141

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           I RE LNAPGC+A+H TEI  S +CDTF+P +DS+ +  WY SFP VEN+IRYSFATYVR
Sbjct: 142 ILREALNAPGCDAVHITEIETSFDCDTFIPAIDSSIFHPWYLSFPMVENNIRYSFATYVR 201

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+SSA ES   ++    +++S++ KF+V+ F FLP+M+  RHEE++YLRL+QEIIS+   
Sbjct: 202 VRSSAVESNGHDSGLSSESSSENSKFDVKKFSFLPKMVFDRHEEFLYLRLVQEIISDGIL 261

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQ+RFNLR++FPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 262 KDDRTGTGTLSKFGCQVRFNLRKTFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 321

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASR+YLDSIGL  REEGDLGPVYGFQWRHFGARY+DMH DY+GQG+DQLLDV+N
Sbjct: 322 HIWDGNASRDYLDSIGLKNREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVVN 381

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVPFN
Sbjct: 382 KIKNNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFN 441

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY LLTC+IAHVC+LVPGDFVHVIGD HVY  HVRPLQEQL  LPKPFP LKIN EKK
Sbjct: 442 IASYGLLTCIIAHVCDLVPGDFVHVIGDTHVYRTHVRPLQEQLQKLPKPFPILKINPEKK 501

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           +IDSFVAADFKL+GY+PH K
Sbjct: 502 NIDSFVAADFKLIGYDPHHK 521


>M0ZJD1_SOLTU (tr|M0ZJD1) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Solanum tuberosum GN=PGSC0003DMG400000736
           PE=3 SV=1
          Length = 527

 Score =  816 bits (2109), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 375/500 (75%), Positives = 431/500 (86%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QRTYQVVVAAT++MGIGK+GKLPWRL TDLKFFK IT  T+DP K+NA+VMGRKTWESIP
Sbjct: 21  QRTYQVVVAATQNMGIGKEGKLPWRLPTDLKFFKGITGTTTDPTKRNAVVMGRKTWESIP 80

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSIE VFVIGGG+
Sbjct: 81  IEHRPLPGRLNVVLTRSGSFDIATAENVVICGSLGSALQLLAASPYCLSIENVFVIGGGE 140

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           IFR+ LNA GC+A+H TEI   I CDTF P +D++ ++ WYSSFP +EN IRYSF TYVR
Sbjct: 141 IFRDSLNADGCDAVHITEIETDIACDTFTPAIDTSVFRPWYSSFPVIENKIRYSFTTYVR 200

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V++S  E+++Q+   + +N SDS   EV++F FLP+M+ ++HEE+MYLRL++EIIS    
Sbjct: 201 VKNSGVETVNQSNSEIPENGSDSSNIEVKSFSFLPKMVFEKHEEFMYLRLVEEIISNGML 260

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMR+NLRRSFPLLTTKKVFWRGV+EELLWFISGST+AKVLQEKGI
Sbjct: 261 KDDRTGTGTLSKFGCQMRYNLRRSFPLLTTKKVFWRGVIEELLWFISGSTSAKVLQEKGI 320

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASR+YLDSIGL +REEGDLGPVYGFQWRHFGARY DMH DYSGQG+DQL DVIN
Sbjct: 321 HIWDGNASRDYLDSIGLKDREEGDLGPVYGFQWRHFGARYIDMHTDYSGQGFDQLADVIN 380

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           K+K+NP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVPFN
Sbjct: 381 KVKNNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFN 440

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASYALLTCMIAHV  LVPGDF+HV+GDAHVY NHVRPLQ+QL  LP+PFP LKIN +KK
Sbjct: 441 IASYALLTCMIAHVSGLVPGDFIHVVGDAHVYRNHVRPLQDQLQKLPRPFPVLKINPQKK 500

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DI+SFVAADF+L GY+PHQ+
Sbjct: 501 DIESFVAADFELTGYDPHQR 520


>K4B3J6_SOLLC (tr|K4B3J6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Solanum lycopersicum GN=Solyc01g109830.2
           PE=3 SV=1
          Length = 527

 Score =  813 bits (2099), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 376/500 (75%), Positives = 429/500 (85%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QRTYQVVVAAT+ MGIGK+GKLPWRL TDLKFFK IT  T+DP K+NA+VMGRKTWESIP
Sbjct: 21  QRTYQVVVAATQSMGIGKEGKLPWRLPTDLKFFKGITGTTTDPTKRNAVVMGRKTWESIP 80

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSIE VFVIGGG+
Sbjct: 81  IEHRPLPGRLNVVLTRSGSFDIATAENVVICGSLGSALQLLASSPYCLSIENVFVIGGGE 140

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           IFR+ LNA GC+A+H TEI   I CDTF P +D++ ++ WYSSFP +EN IRYSF TYVR
Sbjct: 141 IFRDSLNAHGCDAVHITEIETDIACDTFTPAIDTSVFRPWYSSFPVIENKIRYSFTTYVR 200

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V++S  E+++Q+   + +N SDS   EV++F FLP+MI ++HEEYMYLRL+++IIS    
Sbjct: 201 VKNSGVETVNQSNSEIPENGSDSSDIEVKSFSFLPKMIFEKHEEYMYLRLVEDIISNGML 260

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMR+NLRRSFPLLTTK+VFWRGV+EELLWFISGST+AKVLQEKGI
Sbjct: 261 KDDRTGTGTLSKFGCQMRYNLRRSFPLLTTKRVFWRGVIEELLWFISGSTSAKVLQEKGI 320

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASR+YLDSI L +REEGDLGPVYGFQWRHFGARY DMH DYSGQG+DQL DVIN
Sbjct: 321 HIWDGNASRDYLDSIDLKDREEGDLGPVYGFQWRHFGARYIDMHTDYSGQGFDQLADVIN 380

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           K+K+NP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVPFN
Sbjct: 381 KVKNNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFN 440

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASYALLTCMIAHV  LVPGDF+HV+GDAHVY NHVRPLQ+QL  LP+PFP LKIN  KK
Sbjct: 441 IASYALLTCMIAHVSGLVPGDFIHVLGDAHVYRNHVRPLQDQLQKLPRPFPVLKINPLKK 500

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSFVAADF+LVGY+PHQ+
Sbjct: 501 DIDSFVAADFELVGYDPHQR 520


>Q39687_DAUCA (tr|Q39687) Dihydrofolate reductase-thymidylate synthetase
           (Precursor) OS=Daucus carota GN=DHFR-TS PE=3 SV=2
          Length = 577

 Score =  796 bits (2055), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 369/504 (73%), Positives = 425/504 (84%), Gaps = 1/504 (0%)

Query: 22  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 81
           P+ QRTYQVVVAAT++MGIGKDGKLPWRL +D+KFFK++T  TSDP K+NA++MGRKTWE
Sbjct: 67  PDPQRTYQVVVAATQNMGIGKDGKLPWRLPSDMKFFKDVTMTTSDPLKRNAVIMGRKTWE 126

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           SIP+++RPLPGRLNVVLTRSGSFDI T ENVVICGS+          PYC+S+EKVFVIG
Sbjct: 127 SIPIQHRPLPGRLNVVLTRSGSFDIATVENVVICGSMISALELLAGSPYCVSVEKVFVIG 186

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           GGQI+RE LNAPGC+A+H TEI   IECDTF+P +D + +Q WYSSFP VEN IRY F T
Sbjct: 187 GGQIYREALNAPGCDAVHITEIEEHIECDTFIPLLDESVFQPWYSSFPLVENKIRYCFTT 246

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           YVRV++S AE  SQ      D+ SDS  FE+QNF FLP+ + ++HEEY+YL L++ IIS 
Sbjct: 247 YVRVRNSVAELTSQTNGCSSDSKSDSGNFEIQNFSFLPKTVFEKHEEYLYLGLVENIISN 306

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       +S FGCQMRFNLR+SFPLLTTKKVFWRGVVEELLWFISGSTNAK+L+E
Sbjct: 307 GVTKNDRTRTGTVSIFGCQMRFNLRKSFPLLTTKKVFWRGVVEELLWFISGSTNAKILKE 366

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KG++IW+GN SREYLDSIGLT+REEGDLGP+YGFQWRHFGARY+DMH DYSGQG+DQLLD
Sbjct: 367 KGVNIWEGNGSREYLDSIGLTDREEGDLGPIYGFQWRHFGARYTDMHADYSGQGFDQLLD 426

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VI+KIK+NP+DRRII SAWNP DL+LMALPPCHMFAQF+VANGELSCQMYQRSADMGLGV
Sbjct: 427 VISKIKNNPDDRRIIQSAWNPSDLRLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGV 486

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLN-LPKPFPTLKIN 500
           PFNIA+YALLTCMIAHVC+LVPGDFVH IGDAHVY NH+  L E     LPK FP LKIN
Sbjct: 487 PFNIAAYALLTCMIAHVCDLVPGDFVHSIGDAHVYSNHLSDLFETSFRMLPKTFPVLKIN 546

Query: 501 SEKKDIDSFVAADFKLVGYNPHQK 524
           S +KDIDSF AADFKL+GY+PHQK
Sbjct: 547 SGEKDIDSFEAADFKLIGYDPHQK 570


>K3ZSB7_SETIT (tr|K3ZSB7) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Setaria italica GN=Si029497m.g PE=3 SV=1
          Length = 521

 Score =  795 bits (2054), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/500 (73%), Positives = 418/500 (83%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T ATSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLATSDPAKKNAVIMGRKTWESIP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEAIH T+I +SIECDTF+PP+D + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNRPACEAIHLTDIQSSIECDTFIPPIDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ S AE+   N     + ++ + KFE +NF FLP+MI  RHEEY YL L+++II     
Sbjct: 195 VRKSLAETHESNGKESTEVDTKNDKFETENFSFLPKMIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR++FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIA VC+L PGDFVHVIGDAHVY  HVR L+EQ+  +PKPFP LKIN  KK
Sbjct: 435 IASYSLLTYMIAQVCDLSPGDFVHVIGDAHVYRTHVRALEEQIQKMPKPFPILKINPSKK 494

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSFVA+DFKLVGY+PHQK
Sbjct: 495 DIDSFVASDFKLVGYDPHQK 514


>C5Y2E9_SORBI (tr|C5Y2E9) Putative uncharacterized protein Sb05g016730 OS=Sorghum
           bicolor GN=Sb05g016730 PE=3 SV=1
          Length = 521

 Score =  794 bits (2050), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 364/500 (72%), Positives = 418/500 (83%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  TSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLTTSDPAKKNAVIMGRKTWESIP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFV+GGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMNSALELLASTPYCLSIEKVFVVGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEAIH T+I +SIECDTF+PPVD + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ S AE+   N     + ++ + KFE++NF FLPEM+  RHEEY YL L+++II     
Sbjct: 195 VRKSVAETHESNGKESTEVDTKNDKFEIENFSFLPEMVYDRHEEYQYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    +SKFGCQMRFNLR++FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 255 KNDRTGTGTMSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRII+SAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIIMSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIA VC+L PGDFVHVIGDAHVY  HVR L+EQ+  +PKPFP LKIN  KK
Sbjct: 435 IASYSLLTYMIAQVCDLSPGDFVHVIGDAHVYRTHVRALEEQIQKMPKPFPILKINPSKK 494

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSF+A+DFKLVGY+PHQK
Sbjct: 495 DIDSFMASDFKLVGYDPHQK 514


>B9GCZ3_ORYSJ (tr|B9GCZ3) Putative uncharacterized protein OS=Oryza sativa subsp.
           japonica GN=OsJ_35972 PE=3 SV=1
          Length = 521

 Score =  793 bits (2048), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 364/502 (72%), Positives = 419/502 (83%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           NL+R+YQVVV+AT+DMGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWES
Sbjct: 13  NLKRSYQVVVSATRDMGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWES 72

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IPLK+RPLPGRLNV+LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGG
Sbjct: 73  IPLKFRPLPGRLNVILTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGG 132

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           G+I R+ LNAP CEAIH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++
Sbjct: 133 GEILRQSLNAPACEAIHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISF 192

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV  S AE+   +   L  N+S  +KFE++NF FLP+MI +RHEEY YL L+Q+II   
Sbjct: 193 VRVTKSIAEANDSSGKELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNG 252

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQMRFNLRR+FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEK
Sbjct: 253 AKKNDRTGTGTVSKFGCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEK 312

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GIHIWDGNASR+YLDSIGLT+REEGDLGPVYGFQWRHFGA Y+DMH DY G+G+DQL+DV
Sbjct: 313 GIHIWDGNASRQYLDSIGLTQREEGDLGPVYGFQWRHFGAEYTDMHADYVGKGFDQLMDV 372

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           I+KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVP
Sbjct: 373 IDKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVP 432

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTCMIA VC+L PGDFVHVIGDAHVY  HV  L+EQ+   PKPFP LKIN  
Sbjct: 433 FNIASYSLLTCMIAQVCDLSPGDFVHVIGDAHVYRTHVEALEEQMRKQPKPFPILKINPV 492

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFV +DFKLV Y+PH K
Sbjct: 493 KKDIDSFVTSDFKLVRYDPHHK 514


>D7L1V0_ARALL (tr|D7L1V0) Dihydrofolate reductase-thymidylate synthase
           OS=Arabidopsis lyrata subsp. lyrata GN=ARALYDRAFT_480800
           PE=3 SV=1
          Length = 515

 Score =  787 bits (2033), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 369/500 (73%), Positives = 414/500 (82%), Gaps = 10/500 (2%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QRTYQVVVAATK+MGIGKDGKLPW L TDLKFFK+IT  TSD  KKNA+VMGRKTWE+IP
Sbjct: 19  QRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSDSSKKNAVVMGRKTWEAIP 78

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K+RPL GRLNVVLTRSG FDI   ENVV C S+          PYCLSIE+VFVIGGG 
Sbjct: 79  IKHRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLAAPPYCLSIERVFVIGGGD 138

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           I RE LN P C+AIH TEI  SIECDTF+P VD++ YQ W SSFP  EN +R+ F T+VR
Sbjct: 139 ILREALNRPSCDAIHLTEIDTSIECDTFIPAVDTSVYQPWCSSFPVTENGLRFCFTTFVR 198

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+SS  ES          N S SL+F+ + F FLP+M+  +HEE++YL ++++IIS    
Sbjct: 199 VKSSTDES----------NVSQSLQFDGKKFLFLPKMVFDQHEEFLYLNMVEDIISNGNA 248

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQM+FNLRRSFPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 249 KNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 308

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLD IGLTEREEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG+DQLLDVI+
Sbjct: 309 HIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVID 368

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRII+SAWNP DLKLMALPPCHMFAQF+VA GELSCQMYQRSADMGLGVPFN
Sbjct: 369 KIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQRSADMGLGVPFN 428

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLTCM+AHVC+LVPGDF+HVIGDAHVY  HVRPLQEQL N PKPFP LKIN EKK
Sbjct: 429 IASYSLLTCMLAHVCDLVPGDFIHVIGDAHVYKTHVRPLQEQLQNPPKPFPVLKINPEKK 488

Query: 505 DIDSFVAADFKLVGYNPHQK 524
            IDSFVAADF L GY+PH+K
Sbjct: 489 QIDSFVAADFDLTGYDPHKK 508


>K7UAA2_MAIZE (tr|K7UAA2) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Zea mays GN=ZEAMMB73_916665 PE=3 SV=1
          Length = 562

 Score =  787 bits (2032), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/500 (72%), Positives = 417/500 (83%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGK G +PW+L  DLKFFKE+T  T+DP KKNA++MGRKTWESIP
Sbjct: 56  QRNYQVVVAATRDMGIGKGGVMPWKLLGDLKFFKELTLTTTDPAKKNAVIMGRKTWESIP 115

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 116 VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 175

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEAIH T+I +SIECDTF+PPVD + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 176 VLREYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNIRHSFVTFVR 235

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ S AE+   N     + ++ + KFE++NF FLP+++  RHEEY YL L+++II     
Sbjct: 236 VRKSVAETHESNGKESTEIDTKNDKFEIENFSFLPKIVYDRHEEYQYLNLVEDIIRFGAQ 295

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR++FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 296 KNDRTGTGTLSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 355

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLD IGL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 356 HIWDGNASREYLDRIGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 415

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFN
Sbjct: 416 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFN 475

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIA VC+L PGDFVHVIGDAHVY NHVR L+EQ+  +PKPFP LKIN  KK
Sbjct: 476 IASYSLLTYMIAQVCDLSPGDFVHVIGDAHVYRNHVRALEEQIQKMPKPFPILKINPSKK 535

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSF+A+DFKLVGY+PHQK
Sbjct: 536 DIDSFMASDFKLVGYDPHQK 555


>K3ZI20_SETIT (tr|K3ZI20) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Setaria italica GN=Si026222m.g PE=3 SV=1
          Length = 521

 Score =  787 bits (2032), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 364/500 (72%), Positives = 414/500 (82%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T +TSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKEVTLSTSDPAKKNAVIMGRKTWESIP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYC+SIEKVFVIGGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCVSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEAIH T++ +SIECDTF+PP+D + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNGPACEAIHLTDVQSSIECDTFIPPIDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ S  E+   N     + ++ + KFE +NF FLP+MI  RHEEY YL L ++II     
Sbjct: 195 VRKSLEETHVSNGKESTEVDTKNDKFETENFSFLPKMIFDRHEEYHYLNLAEDIIKSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR+ FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRKIFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIA VC L PGDFVHVIGDAHVY  HVR L+EQ+  +PKPFP LKIN  KK
Sbjct: 435 IASYSLLTYMIAQVCGLSPGDFVHVIGDAHVYRTHVRALEEQIQKMPKPFPILKINPSKK 494

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSFVA+DFKLVGY+PHQK
Sbjct: 495 DIDSFVASDFKLVGYDPHQK 514


>B6UD82_MAIZE (tr|B6UD82) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Zea mays PE=2 SV=1
          Length = 523

 Score =  786 bits (2030), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 365/500 (73%), Positives = 416/500 (83%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT DMGIGK G LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWESIP
Sbjct: 17  QRNYQVVVAATCDMGIGKGGVLPWKLLGDLKFFKELTLTTTDPAKKNAVIMGRKTWESIP 76

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 77  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 136

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + R+ LN P CEAIH T+I +SIECDTF+PPVD + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 137 VLRDYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNIRHSFVTFVR 196

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ S AE+   N   L + ++ + KFE++NF FLP+M+  RHEEY YL L+++II     
Sbjct: 197 VRKSVAETHESNGKELTEIDTKNDKFEIENFSFLPKMVHDRHEEYQYLNLVEDIIRFGAQ 256

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR+ FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 257 KNDRTGTGTLSKFGCQMRFNLRKIFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 316

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLD IGL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 317 HIWDGNASREYLDRIGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 376

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFN
Sbjct: 377 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFN 436

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIA VC+L PGDFVHVIGDAHVY NHVR L+EQ+  +PKPFP LKIN  KK
Sbjct: 437 IASYSLLTYMIAQVCDLSPGDFVHVIGDAHVYRNHVRALEEQIQKMPKPFPILKINPSKK 496

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSF+A+DFKLVGY+PHQK
Sbjct: 497 DIDSFMASDFKLVGYDPHQK 516


>Q2R481_ORYSJ (tr|Q2R481) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative, expressed OS=Oryza sativa subsp.
           japonica GN=LOC_Os11g29390 PE=2 SV=1
          Length = 521

 Score =  785 bits (2027), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/500 (72%), Positives = 414/500 (82%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEA+H T+I +SIECDTF+PP+D + +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR SFPLLTTKKVFWRGVVEELLWFISGST+AKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFISGSTSAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V +GELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVESGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIAHVC L PG+FVHVIGDAHVY  HVR L+EQ+  LPKPFP LKIN  KK
Sbjct: 435 IASYSLLTYMIAHVCGLSPGEFVHVIGDAHVYRTHVRALEEQIQKLPKPFPVLKINPLKK 494

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSFVA+DFKLVGY+PHQK
Sbjct: 495 DIDSFVASDFKLVGYDPHQK 514


>I1R077_ORYGL (tr|I1R077) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Oryza glaberrima PE=3 SV=1
          Length = 521

 Score =  783 bits (2022), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/500 (72%), Positives = 413/500 (82%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEA+H T+I +SIECDTF+PP+D   +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLLVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR SFPLLTTKKVFWRGVVEELLWFISGST+AKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFISGSTSAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V +GELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVESGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIAHVC L PG+FVHVIGDAHVY  HVR L+EQ+  LPKPFP LKIN  KK
Sbjct: 435 IASYSLLTYMIAHVCGLSPGEFVHVIGDAHVYRTHVRALEEQIQKLPKPFPILKINPLKK 494

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DIDSFVA+DFKLVGY+PHQK
Sbjct: 495 DIDSFVASDFKLVGYDPHQK 514


>I1IIJ7_BRADI (tr|I1IIJ7) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brachypodium distachyon GN=BRADI4G07810 PE=3
           SV=1
          Length = 517

 Score =  780 bits (2015), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 359/503 (71%), Positives = 417/503 (82%), Gaps = 5/503 (0%)

Query: 22  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 81
           P+++R YQVVVAAT +MGIGKDG LPW+L +DL FFKE+T ATSDP KKNA++MGRKTWE
Sbjct: 13  PDIRRNYQVVVAATHEMGIGKDGALPWKLPSDLNFFKELTMATSDPSKKNAVIMGRKTWE 72

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           SIP K+RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PY L+IEK F+IG
Sbjct: 73  SIPAKFRPLPGRLNVILTRSGSFDFATVENVVICGSLDSSLELLASTPYSLTIEKAFLIG 132

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           GGQ+ R+ LNAP CEAIH T+I ++IECDT++PP+D + +  WYSSFP VEN+IR+SF T
Sbjct: 133 GGQVLRDSLNAPACEAIHLTDIESTIECDTYIPPIDLSVFHPWYSSFPVVENNIRHSFVT 192

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           +VRV+    E    N      N++   +FE++NF FLP+MI +RH+EY YL L+Q+II  
Sbjct: 193 FVRVRKPVTEVNDSN-----GNDAKKERFEIKNFSFLPKMIFERHDEYQYLNLVQDIIQS 247

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       LSKFGCQMRFNLRR+FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQE
Sbjct: 248 GARKNDRTGTGTLSKFGCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQE 307

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KGIHIWDGNASREYLDSIGL++REEGDLGPVYGFQWRHFGA Y+DMH DY+G+GYDQL+D
Sbjct: 308 KGIHIWDGNASREYLDSIGLSQREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGYDQLID 367

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VINKI++NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGV
Sbjct: 368 VINKIRNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGV 427

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASY+LLTCMIA VC+L PGDFVHVIGDAHVY  HVR L+EQ+   PKPFP LKIN 
Sbjct: 428 PFNIASYSLLTCMIAQVCDLSPGDFVHVIGDAHVYSTHVRALEEQIKKQPKPFPILKINP 487

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
            KKDIDSFVA+DF+LV Y+PHQK
Sbjct: 488 VKKDIDSFVASDFELVCYDPHQK 510


>R0HKJ0_9BRAS (tr|R0HKJ0) Uncharacterized protein (Fragment) OS=Capsella rubella
           GN=CARUB_v10013341mg PE=4 SV=1
          Length = 569

 Score =  780 bits (2014), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 368/504 (73%), Positives = 418/504 (82%), Gaps = 6/504 (1%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTW 80
           +P  QRTYQVVVAATK+MGIGKDG LPW L TDLKFFK++T  TSD  KKNA+VMGRKTW
Sbjct: 65  VPEPQRTYQVVVAATKEMGIGKDGNLPWNLPTDLKFFKDVTLTTSDSSKKNAVVMGRKTW 124

Query: 81  ESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVI 140
           ESIP+K+RPL GRLNVVLTRSG FDI   ENVV C S+          PYCLSIE+VFVI
Sbjct: 125 ESIPIKHRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLALPPYCLSIERVFVI 184

Query: 141 GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFA 200
           GGG I RE LN P C+AIH TEI  SIECDTF+P +D++ YQ WYSSFP  EN +R+ F 
Sbjct: 185 GGGDILREALNRPSCDAIHLTEIDTSIECDTFIPAIDTSVYQPWYSSFPITENGLRFCFT 244

Query: 201 TYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIIS 260
           T+VRV+SSA ES  ++      N   SL+F+ + F FLP+M+  +HEE++YL ++++IIS
Sbjct: 245 TFVRVRSSADESSDES------NGLQSLQFDGKKFSFLPKMVFDQHEEFLYLNMVEDIIS 298

Query: 261 EXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQ 320
                        LSKFGCQM+FNLRRSFPLLTTK+VFWRGVVEELLWFISGST+AKVLQ
Sbjct: 299 NGNIKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTSAKVLQ 358

Query: 321 EKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLL 380
           EKGIHIWDGNASREYLD IGL +REEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG+DQLL
Sbjct: 359 EKGIHIWDGNASREYLDGIGLKDREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLL 418

Query: 381 DVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLG 440
           DVI+KIK+NP+DRRII+SAWNP DLKLMALPPCHMFAQF+VA GELSCQMYQRSADMGLG
Sbjct: 419 DVIDKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQRSADMGLG 478

Query: 441 VPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKIN 500
           VPFNIASY+LLTCM+AHVC LVPGDF+HVIGDAHVY NHVRPLQEQLLN PKPFP LKIN
Sbjct: 479 VPFNIASYSLLTCMLAHVCNLVPGDFIHVIGDAHVYRNHVRPLQEQLLNPPKPFPVLKIN 538

Query: 501 SEKKDIDSFVAADFKLVGYNPHQK 524
            EKK IDSFVAADF L GY+PH+K
Sbjct: 539 PEKKQIDSFVAADFDLTGYDPHKK 562


>J3MF38_ORYBR (tr|J3MF38) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Oryza brachyantha GN=OB06G26320 PE=3 SV=1
          Length = 521

 Score =  779 bits (2011), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/502 (70%), Positives = 416/502 (82%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           N+Q  YQVVVAAT+DMGIGKDG LPW++ +DLKFFK+IT  TS+P KKNA+VMGRKTWES
Sbjct: 13  NVQTRYQVVVAATRDMGIGKDGVLPWKVPSDLKFFKDITMTTSNPSKKNAVVMGRKTWES 72

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP+++RPLPGRLN++LTRSGSFD  TAENVV CGS+          PYC ++EK+FVIGG
Sbjct: 73  IPIQFRPLPGRLNIILTRSGSFDFATAENVVTCGSLDSALELLSTTPYCSTVEKIFVIGG 132

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           G++ R+ LNAP CEAIH T+I +S+ECDTF+PP+D + +  WYSS+P VEN IR+SF T+
Sbjct: 133 GEVLRQSLNAPACEAIHLTDIESSVECDTFIPPIDLSVFHPWYSSYPVVENSIRHSFITF 192

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV  S AE+   +   L  N+S   KFE++NF FLP++I +RHEEY YL L+Q+II   
Sbjct: 193 VRVTKSIAEANDSSGKELTGNDSKKNKFEIENFSFLPKVIFERHEEYQYLNLVQDIIRNG 252

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQMRFNLRRSFPLLTTK+VFWRGV+EELLWFISGSTNAKVL+EK
Sbjct: 253 AKKNDRTGTGTISKFGCQMRFNLRRSFPLLTTKRVFWRGVLEELLWFISGSTNAKVLREK 312

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GIHIWDGNASR+YLDSIGL++RE GDLGPVYGFQWRHFGA Y DMH DY+G+G+DQL+DV
Sbjct: 313 GIHIWDGNASRQYLDSIGLSQREVGDLGPVYGFQWRHFGAEYIDMHADYTGKGFDQLMDV 372

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIK+NP+DRRIILSAWNP DL  MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVP
Sbjct: 373 INKIKNNPDDRRIILSAWNPTDLNKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVP 432

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTCMIA VC+L PGDFVHVIGDAHVY  HV+ L+EQ+   PKPFP LKIN  
Sbjct: 433 FNIASYSLLTCMIAQVCDLTPGDFVHVIGDAHVYRTHVQALEEQMQKQPKPFPILKINPL 492

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFV +DFKLV Y+PHQK
Sbjct: 493 KKDIDSFVTSDFKLVRYDPHQK 514


>B9GAQ2_ORYSJ (tr|B9GAQ2) Putative uncharacterized protein OS=Oryza sativa subsp.
           japonica GN=OsJ_33908 PE=2 SV=1
          Length = 574

 Score =  774 bits (1999), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 359/499 (71%), Positives = 411/499 (82%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEA+H T+I +SIECDTF+PP+D + +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR SFPLLTTKKVFWRGVVEELLWFISGST+AKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFISGSTSAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V +GELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVESGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASY+LLT MIAHVC L PG+FVHVIGDAHVY  HVR L+EQ+  LPKPFP LKIN  KK
Sbjct: 435 IASYSLLTYMIAHVCGLSPGEFVHVIGDAHVYRTHVRALEEQIQKLPKPFPVLKINPLKK 494

Query: 505 DIDSFVAADFKLVGYNPHQ 523
           DIDSFVA+DFKLVG +P +
Sbjct: 495 DIDSFVASDFKLVGLSPGE 513



 Score = 94.4 bits (233), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 44/58 (75%), Positives = 48/58 (82%)

Query: 461 LVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVG 518
           L PG+FVHVIGDAHVY  HVR L+EQ+  LPKPFP LKIN  KKDIDSFVA+DFKLV 
Sbjct: 509 LSPGEFVHVIGDAHVYRTHVRALEEQIQKLPKPFPVLKINPLKKDIDSFVASDFKLVA 566


>M7YZH3_TRIUA (tr|M7YZH3) Putative bifunctional dihydrofolate
           reductase-thymidylate synthase OS=Triticum urartu
           GN=TRIUR3_06844 PE=4 SV=1
          Length = 520

 Score =  773 bits (1996), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/502 (70%), Positives = 414/502 (82%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T AT+DP KKNA++MGRKTWES
Sbjct: 12  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATADPSKKNAVIMGRKTWES 71

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP K+RPLPGRLNV+LTRSGS D  T ENVV CGS+          PY  +IEK F+IGG
Sbjct: 72  IPTKFRPLPGRLNVILTRSGSSDYATVENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 131

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           GQ+ RE LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 132 GQVLRESLNASACEAIHLTDIESTIECDTFIPPIDPLVFHPWYSSSPVVENNIRHSFATF 191

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+ SA E+   N   L  N++   KFE+QNF FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 192 VRVRKSAEEANDSNPSELTSNDAKKEKFEIQNFSFLPKMIFEKHDEYQYLNLVQDILRSG 251

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQMRFNLR++FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEK
Sbjct: 252 ARKNDRTGTGTISKFGCQMRFNLRKNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEK 311

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
            I IWDGNASREYLDSIGL++REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL DV
Sbjct: 312 NIRIWDGNASREYLDSIGLSQREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLADV 371

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIK+NP+DRRII+SAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVP
Sbjct: 372 INKIKNNPDDRRIIMSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVP 431

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTCM+A VC+L PG+FVHVIGDAHVY  HV+ L+EQL   PKPFP LKIN  
Sbjct: 432 FNIASYSLLTCMLAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPL 491

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFVA+DFKLV Y+PHQK
Sbjct: 492 KKDIDSFVASDFKLVSYDPHQK 513


>D7MEC7_ARALL (tr|D7MEC7) Predicted protein OS=Arabidopsis lyrata subsp. lyrata
           GN=ARALYDRAFT_656540 PE=3 SV=1
          Length = 565

 Score =  770 bits (1988), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 366/501 (73%), Positives = 411/501 (82%), Gaps = 6/501 (1%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           Q TYQVVVAATK+MGIGKDGKLPW L TDLKFFK++T  TSD  KKNA+VMGRKTWESIP
Sbjct: 63  QSTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDLTLTTSDSAKKNAVVMGRKTWESIP 122

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
            KYRPL GRLNVVLTRS   DI   ENVV C SI          P+ LSIEKVFVIGGG 
Sbjct: 123 TKYRPLSGRLNVVLTRSSGVDIANTENVVTCSSIDSALDLLAAPPFSLSIEKVFVIGGGD 182

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           I RE LN P CEAIH TEI  SI+CDTF+P VD++ YQ W SSFP  EN +R+SF TYVR
Sbjct: 183 ILREALNGPSCEAIHLTEIDTSIDCDTFIPAVDTSAYQPWCSSFPICENGLRFSFTTYVR 242

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFD-FLPEMILQRHEEYMYLRLIQEIISEXX 263
           V+SS+A   S  +D      S  L+ + + F  FLP+MI  RHEE++YL L++EIIS   
Sbjct: 243 VKSSSACESSDVSD-----GSKVLQVDWKKFSSFLPKMIFDRHEEFLYLNLVKEIISNGN 297

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG 323
                     LSKFGCQM+FNLRR+FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKG
Sbjct: 298 LKGDRTGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKG 357

Query: 324 IHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
           I IWDGNASR YLD IGLTEREEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG+DQLLDVI
Sbjct: 358 IRIWDGNASRAYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVI 417

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           +KIK+NP+DRRII+SAWNP DLKLMALPPCHMFAQF+VA+GELSCQMYQRSADMGLGVPF
Sbjct: 418 HKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVADGELSCQMYQRSADMGLGVPF 477

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           NIASY+LLTC++AHVC+LVPGDF+HVIGDAHVY NHVRPLQEQL N PKPFP LKI  EK
Sbjct: 478 NIASYSLLTCILAHVCDLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKIKPEK 537

Query: 504 KDIDSFVAADFKLVGYNPHQK 524
           KDIDSFV+ DF+L+GY+PH+K
Sbjct: 538 KDIDSFVSDDFELIGYDPHKK 558


>R7WB22_AEGTA (tr|R7WB22) Putative bifunctional dihydrofolate
           reductase-thymidylate synthase OS=Aegilops tauschii
           GN=F775_09243 PE=4 SV=1
          Length = 520

 Score =  768 bits (1984), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 351/502 (69%), Positives = 413/502 (82%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T AT+DP KKNA++MGRKTWES
Sbjct: 12  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATADPSKKNAVIMGRKTWES 71

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP K+RPLPGRLNV+LTRS S D  T ENVV CGS+          PY  +IEK F+IGG
Sbjct: 72  IPTKFRPLPGRLNVILTRSDSSDYATVENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 131

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           GQ+ RE+LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 132 GQVLRELLNASACEAIHLTDIESTIECDTFIPPIDPLVFHPWYSSSPVVENNIRHSFATF 191

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+ SA E+   N   L  N++   KFE+Q F FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 192 VRVRKSAEEANDSNLSELTSNDAKKKKFEIQIFSFLPKMIFEKHDEYQYLNLVQDILRSG 251

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQMRFNLR++FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEK
Sbjct: 252 ARKNDRTGTGTISKFGCQMRFNLRKNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEK 311

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
            I IWDGNASREYLDSIGL++REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL DV
Sbjct: 312 NIRIWDGNASREYLDSIGLSQREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLADV 371

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIK+NP+DRRII+SAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVP
Sbjct: 372 INKIKNNPDDRRIIMSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVP 431

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTCMIA VC+L PGDFVHV+GDAHVY  HV+ L+EQL   PKPFP LKIN  
Sbjct: 432 FNIASYSLLTCMIAQVCDLSPGDFVHVMGDAHVYSTHVQALEEQLQKQPKPFPILKINPL 491

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDID+FVA+DFKLV Y+PHQK
Sbjct: 492 KKDIDAFVASDFKLVSYDPHQK 513


>R0F3G9_9BRAS (tr|R0F3G9) Uncharacterized protein OS=Capsella rubella
           GN=CARUB_v10004370mg PE=4 SV=1
          Length = 628

 Score =  768 bits (1983), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 366/502 (72%), Positives = 412/502 (82%), Gaps = 7/502 (1%)

Query: 24  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 83
           LQRTYQVVVAATK+MGIGKDGKLPW L +DLKFFK++T  TSD  KKNA+VMGRKTWESI
Sbjct: 126 LQRTYQVVVAATKEMGIGKDGKLPWNLPSDLKFFKDLTLTTSDSAKKNAVVMGRKTWESI 185

Query: 84  PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
           P KYRPL GRLN+VLTRS   +I   ENVV C SI          PY +SI+KVFVIGGG
Sbjct: 186 PSKYRPLCGRLNIVLTRSSGSNIANTENVVTCSSIDSALDLLAAPPYSMSIDKVFVIGGG 245

Query: 144 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 203
            I RE LN P CEAIH TEI  SI+CDTF+PP+D++ YQ WYSSFP  EN +RYSF T+V
Sbjct: 246 DILRESLNRPRCEAIHLTEIDKSIDCDTFIPPIDTSAYQPWYSSFPICENGLRYSFTTFV 305

Query: 204 RVQSSAA-ESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           RV+SS+A ES  +  +      S +L    +   FLP+MI  RHEE +YL L++EIIS  
Sbjct: 306 RVKSSSAGESFKERAE------SHALVDWKKFSSFLPKMIFDRHEELLYLNLVKEIISNG 359

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                       SKFGCQM+FNLRR+FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEK
Sbjct: 360 NLKNDRTGTGTFSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEK 419

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GI IWDGNASR YLD IGLTEREEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG+DQLLDV
Sbjct: 420 GIRIWDGNASRAYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDV 479

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIK+NP+DRRII+SAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVP
Sbjct: 480 INKIKNNPDDRRIIMSAWNPPDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVP 539

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTC++AHVC+LVPGDF+HVIGDAHVY NHVRPLQEQL N PKPFP LKIN E
Sbjct: 540 FNIASYSLLTCILAHVCDLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPE 599

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KK IDSFVA DF+L+GY+PH+K
Sbjct: 600 KKHIDSFVADDFELIGYDPHKK 621


>F6H1I8_VITVI (tr|F6H1I8) Putative uncharacterized protein OS=Vitis vinifera
           GN=VIT_18s0001g12940 PE=3 SV=1
          Length = 502

 Score =  768 bits (1982), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 360/495 (72%), Positives = 412/495 (83%), Gaps = 8/495 (1%)

Query: 38  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 97
           MGIGKDGKLPW L +DLKFFKE+T  TSDPGKKNA+VMGRKTWESIPL YRPLPGRLNVV
Sbjct: 1   MGIGKDGKLPWNLPSDLKFFKELTMTTSDPGKKNAVVMGRKTWESIPLNYRPLPGRLNVV 60

Query: 98  LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 157
           LTRSGSFD  T ENVVICGS+          PYCLSI+KVFVIGGGQI RE LNAPGC+A
Sbjct: 61  LTRSGSFDNATVENVVICGSMPSALKLLAESPYCLSIDKVFVIGGGQILREALNAPGCDA 120

Query: 158 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 217
           IH T+I  SIECDTF+P +D++ +  WYSS P +EN+I YSF TYVRV+SSA ES + ++
Sbjct: 121 IHITKIETSIECDTFIPTIDTSVFHPWYSSVPLLENNILYSFVTYVRVRSSALESFALSS 180

Query: 218 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 277
              F+  S   K ++Q F FLP+MI +RH+E+MYLR ++EIIS             +SKF
Sbjct: 181 GVNFNGGSVPNKLKIQGFTFLPKMIFERHDEFMYLRQLKEIISSGAHKADKTGTGTVSKF 240

Query: 278 GCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD 337
           GCQMRFNLR SFPLLTTK+VFWRGVVEELLWFISGSTNAKVLQ+K IHIWDGNASREYLD
Sbjct: 241 GCQMRFNLRLSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQKKDIHIWDGNASREYLD 300

Query: 338 S--------IGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHN 389
                    IGLT+REEGDLGP+YGFQWRHFGARY++MH DY G+G+DQLLDVI+KIK+ 
Sbjct: 301 RQLLGYWNLIGLTDREEGDLGPIYGFQWRHFGARYTNMHADYMGKGFDQLLDVIDKIKNK 360

Query: 390 PNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYA 449
           P+DRRIILS+WNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVPFNIASYA
Sbjct: 361 PDDRRIILSSWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYA 420

Query: 450 LLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           LLTCMIAHVC ++PGDF+ +IGDAH+Y  H+RPL+EQL  LPKPFP LKIN +KKDI+SF
Sbjct: 421 LLTCMIAHVCGILPGDFILIIGDAHIYKTHIRPLEEQLQKLPKPFPILKINPQKKDIESF 480

Query: 510 VAADFKLVGYNPHQK 524
           VAADF+L+GYNPHQK
Sbjct: 481 VAADFELIGYNPHQK 495


>B8BPG2_ORYSI (tr|B8BPG2) Putative uncharacterized protein OS=Oryza sativa subsp.
           indica GN=OsI_38205 PE=3 SV=1
          Length = 494

 Score =  767 bits (1981), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/487 (72%), Positives = 404/487 (82%)

Query: 38  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 97
           MGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWESIPLK+RPLPGRLNV+
Sbjct: 1   MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60

Query: 98  LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 157
           LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGGG+I R+ LNAP CEA
Sbjct: 61  LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120

Query: 158 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 217
           IH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++VRV  S AE+   + 
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180

Query: 218 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 277
             L  N+S  +KFE++NF FLP+MI +RHEEY YL L+Q+II              +SKF
Sbjct: 181 KELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240

Query: 278 GCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD 337
           GCQMRFNLRR+FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEKGIHIWDGNASR+YLD
Sbjct: 241 GCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD 300

Query: 338 SIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIIL 397
           SIGLT+REEGDLGPVYGFQWRHFGA Y+DMH DY G+G+DQL+DVI+KIK+NP+DRRIIL
Sbjct: 301 SIGLTQREEGDLGPVYGFQWRHFGAEYTDMHADYVGKGFDQLMDVIDKIKNNPDDRRIIL 360

Query: 398 SAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAH 457
           SAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFNIASY+LLTCMIA 
Sbjct: 361 SAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQ 420

Query: 458 VCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLV 517
           VC+L PGDFVHVIGDAHVY  HV  L+EQ+   PKPFP LKIN  KKDIDSFV +DFKLV
Sbjct: 421 VCDLSPGDFVHVIGDAHVYRTHVEALEEQMRKQPKPFPILKINPVKKDIDSFVTSDFKLV 480

Query: 518 GYNPHQK 524
            Y+PH K
Sbjct: 481 RYDPHHK 487


>B7FA29_ORYSJ (tr|B7FA29) cDNA, clone: J100037K11, full insert sequence OS=Oryza
           sativa subsp. japonica PE=2 SV=1
          Length = 494

 Score =  767 bits (1981), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 353/487 (72%), Positives = 404/487 (82%)

Query: 38  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 97
           MGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWESIPLK+RPLPGRLNV+
Sbjct: 1   MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60

Query: 98  LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 157
           LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGGG+I R+ LNAP CEA
Sbjct: 61  LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120

Query: 158 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 217
           IH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++VRV  S AE+   + 
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180

Query: 218 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 277
             L  N+S  +KFE++NF FLP+MI +RHEEY YL L+Q+II              +SKF
Sbjct: 181 KELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240

Query: 278 GCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD 337
           GCQMRFNLRR+FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEKGIHIWDGNASR+YLD
Sbjct: 241 GCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD 300

Query: 338 SIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIIL 397
           SIGLT+REEGDLGPVYGFQWRHFGA Y+DMH DY G+G+DQL+DVI+KIK+NP+DRRIIL
Sbjct: 301 SIGLTQREEGDLGPVYGFQWRHFGAEYTDMHADYVGKGFDQLMDVIDKIKNNPDDRRIIL 360

Query: 398 SAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAH 457
           SAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFNIASY+LLTCMIA 
Sbjct: 361 SAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQ 420

Query: 458 VCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLV 517
           VC+L PGDFVHVIGDAHVY  HV  L+EQ+   PKPFP LKIN  KKDIDSFV +DFKLV
Sbjct: 421 VCDLSPGDFVHVIGDAHVYRTHVEALEEQMRKQPKPFPILKINPVKKDIDSFVTSDFKLV 480

Query: 518 GYNPHQK 524
            Y+PH K
Sbjct: 481 RYDPHHK 487


>M4D4Y6_BRARP (tr|M4D4Y6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brassica rapa subsp. pekinensis GN=Bra011543
           PE=3 SV=1
          Length = 499

 Score =  766 bits (1977), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 363/501 (72%), Positives = 409/501 (81%), Gaps = 15/501 (2%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAATK+MGIGKDGKLPW L TDLKFFKE+T  TSD  KKNA+VMGRKTWESIP
Sbjct: 6   QRAYQVVVAATKEMGIGKDGKLPWSLPTDLKFFKELTLTTSDSSKKNAVVMGRKTWESIP 65

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
            KY+PL GRLNVVLTRS  FDI  AENVV C SI          PY LSIEKVFVIGGG+
Sbjct: 66  TKYKPLSGRLNVVLTRSSGFDIANAENVVTCRSIDSALDLLAGPPYRLSIEKVFVIGGGE 125

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + R+ LN P CEAIH TEI  S+ECDTF+P +DS+ YQ W SS P  EN +R+SF TYVR
Sbjct: 126 VLRDSLNGPRCEAIHLTEIDTSVECDTFVPEIDSSAYQPWCSSLPVCENGLRFSFTTYVR 185

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFD-FLPEMILQRHEEYMYLRLIQEIISEXX 263
           V+S              D + ++L  + + F   LP+ + +RHEE++YL ++ EIIS   
Sbjct: 186 VKS--------------DESKEALGVDWRKFSSLLPKKVFERHEEFLYLNMVNEIISSGN 231

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG 323
                     LSKFGCQM FNLRRSFPLLTTK+VFWRGVVEELLWFISGSTNAK+LQEKG
Sbjct: 232 VKNDRTGTGTLSKFGCQMTFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNAKLLQEKG 291

Query: 324 IHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
           IHIWDGNASREYLD IGLTEREEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG+DQLLDVI
Sbjct: 292 IHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVI 351

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           NKIK+NP+DRRII+SAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVPF
Sbjct: 352 NKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPF 411

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           NIASY+LLTC++AHVC+LVPGDF+HVIGDAHVY NHVRPLQEQL N PKPFP +KIN EK
Sbjct: 412 NIASYSLLTCILAHVCDLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVMKINPEK 471

Query: 504 KDIDSFVAADFKLVGYNPHQK 524
           K IDSFVAADF+L+GY+PH+K
Sbjct: 472 KHIDSFVAADFELIGYDPHKK 492


>I1R663_ORYGL (tr|I1R663) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Oryza glaberrima PE=3 SV=1
          Length = 494

 Score =  765 bits (1975), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 351/487 (72%), Positives = 405/487 (83%)

Query: 38  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 97
           MGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWESIPLK+RPLPGRLNV+
Sbjct: 1   MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60

Query: 98  LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 157
           LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGGG+I R+ LNAP CEA
Sbjct: 61  LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120

Query: 158 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 217
           IH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++VRV  S AE+   + 
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSIFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180

Query: 218 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 277
             L  N+S  +KF+++NF FLP+MI +RHEEY YL L+Q+II              +SKF
Sbjct: 181 KELTGNDSKKVKFQIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240

Query: 278 GCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLD 337
           GCQMRFNLRR+FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEKGIHIWDGNASR+YLD
Sbjct: 241 GCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD 300

Query: 338 SIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIIL 397
           SIGLT+REEGDLGPVYGFQWRHFGA Y+DMH DY G+G+DQL+DVI+KIK+NP+DRRIIL
Sbjct: 301 SIGLTQREEGDLGPVYGFQWRHFGAEYTDMHADYVGKGFDQLMDVIDKIKNNPDDRRIIL 360

Query: 398 SAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAH 457
           SAWNP DLK MALPPCHMFAQF+V +GELSCQMYQRSADMGLGVPFNIASY+LLTCMIA 
Sbjct: 361 SAWNPTDLKKMALPPCHMFAQFYVEDGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQ 420

Query: 458 VCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLV 517
           VC+L PGDF+HVIGDAHVY  HV  L+EQ+   PKPFP LKIN  KKDIDSFV +DFKLV
Sbjct: 421 VCDLSPGDFIHVIGDAHVYRTHVEALEEQMRKQPKPFPILKINPVKKDIDSFVTSDFKLV 480

Query: 518 GYNPHQK 524
            Y+PHQK
Sbjct: 481 RYDPHQK 487


>M0YHZ0_HORVD (tr|M0YHZ0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Hordeum vulgare var. distichum PE=3 SV=1
          Length = 572

 Score =  764 bits (1973), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 354/502 (70%), Positives = 411/502 (81%), Gaps = 5/502 (0%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T ATSDP KKNA++MGRKTWES
Sbjct: 69  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATSDPSKKNAVIMGRKTWES 128

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP K+RPLPGRLNV+LTRSGS D   AENVV CGS+          PY  +IEK F+IGG
Sbjct: 129 IPTKFRPLPGRLNVILTRSGSSDYAKAENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 188

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           GQ+ RE LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 189 GQVLRESLNASACEAIHLTDIESTIECDTFIPPIDPLIFHPWYSSSPVVENNIRHSFATF 248

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+ SA E+   N      N++   KFE+Q F FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 249 VRVRKSAEEANDPNV-----NDTKKEKFEIQIFSFLPKMIFEKHDEYQYLNLVQDILRTG 303

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQMRFNLR++FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEK
Sbjct: 304 ARKNDRTGTGTISKFGCQMRFNLRKNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEK 363

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
            I IWDGNASREYLDSIGL++REEGDLGPVYGFQWRHFGA YSDMH DY+G+G+DQL DV
Sbjct: 364 NIRIWDGNASREYLDSIGLSQREEGDLGPVYGFQWRHFGAEYSDMHADYTGKGFDQLADV 423

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVP
Sbjct: 424 INKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVP 483

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTCMIA VC+L PG+FVHVIGDAHVY  HV+ L+EQL   PKPFP LKIN  
Sbjct: 484 FNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPL 543

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFVA+DFKL  Y+PHQK
Sbjct: 544 KKDIDSFVASDFKLACYDPHQK 565


>F2DUZ4_HORVD (tr|F2DUZ4) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Hordeum vulgare var. distichum PE=2 SV=1
          Length = 516

 Score =  763 bits (1969), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 354/502 (70%), Positives = 411/502 (81%), Gaps = 5/502 (0%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T ATSDP KKNA++MGRKTWES
Sbjct: 13  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATSDPSKKNAVIMGRKTWES 72

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP K+RPLPGRLNV+LTRSGS D   AENVV CGS+          PY  +IEK F+IGG
Sbjct: 73  IPTKFRPLPGRLNVILTRSGSSDYAKAENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 132

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           GQ+ RE LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 133 GQVLRESLNASACEAIHLTDIESTIECDTFIPPIDPLIFHPWYSSSPVVENNIRHSFATF 192

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+ SA E+   N      N++   KFE+Q F FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 193 VRVRKSAEEANDPNV-----NDTKKEKFEIQIFSFLPKMIFEKHDEYQYLNLVQDILRTG 247

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQMRFNLR++FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEK
Sbjct: 248 ARKNDRTGTGTISKFGCQMRFNLRKNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEK 307

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
            I IWDGNASREYLDSIGL++REEGDLGPVYGFQWRHFGA YSDMH DY+G+G+DQL DV
Sbjct: 308 NIRIWDGNASREYLDSIGLSQREEGDLGPVYGFQWRHFGAEYSDMHADYTGKGFDQLADV 367

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVP
Sbjct: 368 INKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVP 427

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTCMIA VC+L PG+FVHVIGDAHVY  HV+ L+EQL   PKPFP LKIN  
Sbjct: 428 FNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPL 487

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KKDIDSFVA+DFKL  Y+PHQK
Sbjct: 488 KKDIDSFVASDFKLACYDPHQK 509


>M4D9B9_BRARP (tr|M4D9B9) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brassica rapa subsp. pekinensis GN=Bra013079
           PE=3 SV=1
          Length = 618

 Score =  762 bits (1967), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 361/503 (71%), Positives = 404/503 (80%), Gaps = 9/503 (1%)

Query: 22  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 81
           P+ QRTYQVVVAATK MGIGKDGKLPW L TDLKFFK+IT  TSDP KKNA+VMGRKTWE
Sbjct: 12  PDPQRTYQVVVAATKQMGIGKDGKLPWNLPTDLKFFKDITQTTSDPTKKNAVVMGRKTWE 71

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           +IP K+RPLPGRLNVVLTRSG FDI   ENVV C S+          PYCLSIE+VFVIG
Sbjct: 72  AIPTKHRPLPGRLNVVLTRSGGFDIANTENVVTCSSVDSALHLLAAPPYCLSIERVFVIG 131

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           GG I RE LN P C+AIH TEI  SIECDTF+P VD+  YQ W SS P  EN +R+ F +
Sbjct: 132 GGDILREALNMPSCDAIHLTEIDTSIECDTFIPEVDTCVYQPWCSSVPVTENGLRFRFTS 191

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           +VRV+SSA ES S  +          L+F+ + F FLP+M+  +HEE+ YL ++ +IIS 
Sbjct: 192 FVRVKSSADESSSNGS------QQSPLQFDGKRFSFLPKMVFDQHEEFRYLNMVGDIISN 245

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       LSKFG QM+FNLRRSFPLLTTK+VFWRGVVEELLWFISGSTNAKVLQ 
Sbjct: 246 GNVKNDRTGTGTLSKFGTQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQG 305

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           K IHIWDGNASREYLD IGL+EREEGDLG VYGFQWRHFGA+Y+DMH DY+ QG+DQL D
Sbjct: 306 KDIHIWDGNASREYLDGIGLSEREEGDLGRVYGFQWRHFGAKYTDMHADYTSQGFDQLAD 365

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VI+KIK+NP+DRRIILSAWNP DLKLMALPPCHMFAQF+VA GELSCQMYQRSADM LGV
Sbjct: 366 VIDKIKNNPDDRRIILSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQRSADMSLGV 425

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASY+LLTCM+AHVC+LVPGDFVHVIGDAHVY  HVRPLQEQL N PKPFP   IN+
Sbjct: 426 PFNIASYSLLTCMLAHVCDLVPGDFVHVIGDAHVYRTHVRPLQEQLQNPPKPFP---INA 482

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
           EKKDIDSFVA DF L+GY PH+K
Sbjct: 483 EKKDIDSFVADDFDLIGYEPHKK 505


>J3ND79_ORYBR (tr|J3ND79) Uncharacterized protein OS=Oryza brachyantha
           GN=OB12G19370 PE=3 SV=1
          Length = 917

 Score =  761 bits (1965), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 354/509 (69%), Positives = 411/509 (80%), Gaps = 8/509 (1%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           NLQ  YQVVVAAT DMGIGKDG LPW+L +DLKFFK+IT  TS+P KKNA+VMGRKTWES
Sbjct: 403 NLQTRYQVVVAATSDMGIGKDGVLPWKLPSDLKFFKDITMTTSNPSKKNAVVMGRKTWES 462

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP+++RPLPGRLN++LTRSGSFD  TAENVV CGS+          PYC ++EK+FVIGG
Sbjct: 463 IPIQFRPLPGRLNIILTRSGSFDFATAENVVTCGSLDSALELLSTTPYCSTVEKIFVIGG 522

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           G++ R+ LNAP CEAIH T+I +SI+CDTF+PP+D + +  WYSS+P VEN IR+SF T+
Sbjct: 523 GEVLRQSLNAPACEAIHLTDIESSIQCDTFIPPIDLSVFHPWYSSYPVVENSIRHSFITF 582

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV  S AE+   +   L  N+S   KFE++NF FLP++I QRHEEY YL L+Q+II   
Sbjct: 583 VRVTKSIAEANDSSGKELTGNDSKKNKFEIENFSFLPKVIFQRHEEYQYLNLVQDIIRNG 642

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                       SKFGCQMRFNLRRSFPLLTTK+VFWRGV+EELLWFISGSTNAKVL+EK
Sbjct: 643 AKKNDRTGTGTTSKFGCQMRFNLRRSFPLLTTKRVFWRGVLEELLWFISGSTNAKVLREK 702

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA-------RYSDMHKDYSGQG 375
           GIHIWDGNASR+YLDSIGL++REEGDLGPVYGFQWRHFGA       RY DMH DY+G+G
Sbjct: 703 GIHIWDGNASRQYLDSIGLSQREEGDLGPVYGFQWRHFGAEKVYIIDRYIDMHADYTGKG 762

Query: 376 YDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSA 435
           +DQL+DVINKIK+NP+  RIILSAWNP DL  MAL PCHMFAQF+V NGEL CQMYQRSA
Sbjct: 763 FDQLMDVINKIKNNPDVIRIILSAWNPTDLNKMALSPCHMFAQFYVENGEL-CQMYQRSA 821

Query: 436 DMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFP 495
           DMGLGVPFNIASY+LLTCMIA VC+L PGDFVHV GDAH+Y  HV+ L+EQ+   PKPFP
Sbjct: 822 DMGLGVPFNIASYSLLTCMIAQVCDLSPGDFVHVRGDAHLYRTHVQALEEQMPKQPKPFP 881

Query: 496 TLKINSEKKDIDSFVAADFKLVGYNPHQK 524
            LKIN  KKDIDSFV +DFKLV Y+PHQK
Sbjct: 882 ILKINPLKKDIDSFVTSDFKLVRYDPHQK 910


>K3ZSR0_SETIT (tr|K3ZSR0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Setaria italica GN=Si029497m.g PE=3 SV=1
          Length = 489

 Score =  745 bits (1924), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 344/471 (73%), Positives = 392/471 (83%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T ATSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLATSDPAKKNAVIMGRKTWESIP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEAIH T+I +SIECDTF+PP+D + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNRPACEAIHLTDIQSSIECDTFIPPIDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ S AE+   N     + ++ + KFE +NF FLP+MI  RHEEY YL L+++II     
Sbjct: 195 VRKSLAETHESNGKESTEVDTKNDKFETENFSFLPKMIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR++FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL+DVI+
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVID 374

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK+NP+DRRIILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFN
Sbjct: 375 KIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFN 434

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFP 495
           IASY+LLT MIA VC+L PGDFVHVIGDAHVY  HVR L+EQ+  +PKPFP
Sbjct: 435 IASYSLLTYMIAQVCDLSPGDFVHVIGDAHVYRTHVRALEEQIQKMPKPFP 485


>B9R7Y4_RICCO (tr|B9R7Y4) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative OS=Ricinus communis GN=RCOM_1595270
           PE=3 SV=1
          Length = 591

 Score =  743 bits (1917), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 349/499 (69%), Positives = 406/499 (81%), Gaps = 2/499 (0%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
            R YQVVVAAT+DMGIGKDGKLPWRL +DLKFFKE+T  TS PGK+NA+VMGRKTWESIP
Sbjct: 84  NRRYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKELTLTTSSPGKRNAVVMGRKTWESIP 143

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           LKYRPLPGRLN+VLT SG  DI TAE+V+ CGSI          PY   IEKVF IGGGQ
Sbjct: 144 LKYRPLPGRLNIVLTCSGGCDITTAEDVLTCGSIPSALELLAEAPYSFLIEKVFFIGGGQ 203

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           I R+ +NAPGC+AIH TEI  SIECDTF+P +D + +  WYSS P VEN++RYSFATYVR
Sbjct: 204 ILRKTINAPGCDAIHITEIETSIECDTFIPVIDFSLFHPWYSSLPIVENNVRYSFATYVR 263

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V++S   +LS++     + N  S  FEV+NF FLP +I ++H+EYMYLRL ++IIS    
Sbjct: 264 VKNSENGTLSKSASA--NGNLSSNTFEVKNFTFLPSIIYKKHDEYMYLRLAEQIISNGTL 321

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFG QM++NLR+SFPLLTTK+VFW GVVEELLWFISGSTNAKVLQEKGI
Sbjct: 322 KDDRTGTGTLSKFGGQMQYNLRKSFPLLTTKRVFWMGVVEELLWFISGSTNAKVLQEKGI 381

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
           HIWDGNASR+YLDSIGL + EE DLGP+YGFQWR+FGARY+DMH DYSGQG+DQL+DVI+
Sbjct: 382 HIWDGNASRDYLDSIGLKDIEESDLGPIYGFQWRYFGARYTDMHADYSGQGFDQLVDVID 441

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
           KIK  P+DR IIL +WNP DLKLMA PPCHMFAQF+VANGELSCQMYQRSAD+GLGVPFN
Sbjct: 442 KIKSKPDDRCIILRSWNPSDLKLMAFPPCHMFAQFYVANGELSCQMYQRSADIGLGVPFN 501

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IA YALLTC+IAHVC LVPGDF+H+IGDA V   H+ PLQ+QL  LP PFP L+IN  KK
Sbjct: 502 IAFYALLTCIIAHVCALVPGDFIHLIGDARVCTTHIGPLQKQLQKLPTPFPILRINPAKK 561

Query: 505 DIDSFVAADFKLVGYNPHQ 523
           DIDSF A+DF+L+GY+PH+
Sbjct: 562 DIDSFEASDFQLIGYDPHE 580


>G7J767_MEDTR (tr|G7J767) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Medicago truncatula GN=MTR_3g117080 PE=3
           SV=1
          Length = 504

 Score =  739 bits (1909), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 349/437 (79%), Positives = 381/437 (87%), Gaps = 1/437 (0%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 82
           NLQRTYQVVVAATK+MGIGKDGKLPWRL TDLKFFKEITT TS+PGKKNAIVMGRKTWES
Sbjct: 62  NLQRTYQVVVAATKEMGIGKDGKLPWRLPTDLKFFKEITTTTSEPGKKNAIVMGRKTWES 121

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IPL++RPL GRLNVVLTRSG+FDI  AENVVIC S+          PY  SIEK+FVIGG
Sbjct: 122 IPLQFRPLLGRLNVVLTRSGTFDIAAAENVVICRSMSSALELLAASPYHTSIEKIFVIGG 181

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 202
           G+IFRE LNAP CEAIH TEI ++IECDTFMPP+D+T +Q WYSSF KVEN+IRYSF TY
Sbjct: 182 GEIFREALNAPECEAIHLTEIQSNIECDTFMPPIDTTIFQPWYSSFTKVENNIRYSFTTY 241

Query: 203 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 262
           VRV+SSAAE   +NTD  FD+NS S KFEVQNF FLP+MI +RH EYMYL L+QEIIS+ 
Sbjct: 242 VRVRSSAAE-YPKNTDSFFDSNSASKKFEVQNFSFLPKMIFERHAEYMYLNLVQEIISQG 300

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      LS FGCQMRFNLRR FPLLTTK+VFWRGVVEELLWFISGSTNAKVLQ+K
Sbjct: 301 TTKGDRTGTGTLSAFGCQMRFNLRRGFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQQK 360

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GIHIWD NASRE+LDSIGL+EREEGDLGPVYGFQWRHFGA+Y++MH DY+ QG DQLLDV
Sbjct: 361 GIHIWDDNASREFLDSIGLSEREEGDLGPVYGFQWRHFGAKYTNMHGDYANQGLDQLLDV 420

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           INKIKHNP+DRRIILSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVP
Sbjct: 421 INKIKHNPDDRRIILSAWNPADLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVP 480

Query: 443 FNIASYALLTCMIAHVC 459
           FNIASYALLTCMIAH+C
Sbjct: 481 FNIASYALLTCMIAHIC 497


>M4DMC9_BRARP (tr|M4DMC9) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brassica rapa subsp. pekinensis GN=Bra017662
           PE=3 SV=1
          Length = 504

 Score =  736 bits (1900), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 355/502 (70%), Positives = 407/502 (81%), Gaps = 16/502 (3%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-KKNAIVMGRKTWESI 83
           + +YQVVVAATK+MGIGKDGKLPW L TDLKFFK++T  TSD   KKNA+VMGR+TWESI
Sbjct: 10  RASYQVVVAATKEMGIGKDGKLPWTLPTDLKFFKDLTLTTSDSTTKKNAVVMGRRTWESI 69

Query: 84  PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
           P K+RPL GRLNVVLTRS  F+I  AENVV C S+          PY LSIEKVFVIGGG
Sbjct: 70  PAKHRPLSGRLNVVLTRSSGFEIANAENVVTCRSLDSALELLAGPPYSLSIEKVFVIGGG 129

Query: 144 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 203
           ++ R+ LN   CEAIH TEI   IECDTF+P VD++ YQ W SS P  EN +R++F TYV
Sbjct: 130 EVLRDSLNGARCEAIHLTEIDTCIECDTFVPAVDASAYQPWCSSLPMCENGVRFAFTTYV 189

Query: 204 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFD-FLPEMILQRHEEYMYLRLIQEIISEX 262
           RV+S              D + ++L+ + + F   LP+ + +RHEE++YL L+ EIIS  
Sbjct: 190 RVKS--------------DESKEALQVDWKKFSSLLPKKVFERHEEFLYLNLVDEIISSG 235

Query: 263 XXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      +SKFGCQM FNLRRSFPLLTTK+VFWRGVVEELLWFISGSTNAK+LQEK
Sbjct: 236 NLKNDRTGTGTVSKFGCQMTFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNAKLLQEK 295

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
           GIHIWDGNASREYLD IGLTEREEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG+DQLLDV
Sbjct: 296 GIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDV 355

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           +NKIK+NP+DRRII+SAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRSADMGLGVP
Sbjct: 356 VNKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVP 415

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLTC++AHVC LVPGDF+HVIGDAHVY NHVRPLQEQL N PKPFP LKIN E
Sbjct: 416 FNIASYSLLTCILAHVCYLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPE 475

Query: 503 KKDIDSFVAADFKLVGYNPHQK 524
           KK IDSFVAADF+L+GY+PH+K
Sbjct: 476 KKHIDSFVAADFELIGYDPHKK 497


>D8SA97_SELML (tr|D8SA97) Putative uncharacterized protein OS=Selaginella
           moellendorffii GN=SELMODRAFT_233517 PE=3 SV=1
          Length = 509

 Score =  678 bits (1750), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 318/499 (63%), Positives = 383/499 (76%), Gaps = 20/499 (4%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           R +QVVVAAT D+GIGK+GKLPW + +D+ FFK IT+  +D  KKNA+VMGR+TWESIP 
Sbjct: 24  RAFQVVVAATTDLGIGKEGKLPWSVPSDMAFFKRITSEAADARKKNAVVMGRRTWESIPA 83

Query: 86  KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 145
           K+RPLPGR+NVVL+R+G  ++G  +  ++C S+          P+  S+E VFVIGGG++
Sbjct: 84  KFRPLPGRVNVVLSRAG-LELG--DKAIVCSSLDSALGILAAPPFDSSVEAVFVIGGGEV 140

Query: 146 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 205
           FRE + +P C AIH TEI    ECDTFMP +D T ++LWY+S P   N++R+SF TYVR 
Sbjct: 141 FREAMVSPLCTAIHLTEIQTFFECDTFMPALDLTCFRLWYASSPATVNNVRHSFHTYVRN 200

Query: 206 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 265
           ++    +++          + SL         +PE + +RHEEY YL LI++II      
Sbjct: 201 KALDVRNVA---------GTSSLP--------IPEFVRERHEEYQYLNLIKDIIETGNTK 243

Query: 266 XXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIH 325
                   +SKFGCQMRFNLR SFPLLTTK+VFWRGVVEELLWFISGSTNAKVL++KGIH
Sbjct: 244 SDRTGTGTISKFGCQMRFNLRNSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLEDKGIH 303

Query: 326 IWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINK 385
           IW GN SREYLDSIGL+EREE DLGPVYGFQWRHFGARYS MH DY+GQG DQL +VI+K
Sbjct: 304 IWKGNGSREYLDSIGLSEREENDLGPVYGFQWRHFGARYSTMHDDYTGQGVDQLAEVIDK 363

Query: 386 IKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNI 445
           IK+ P+DRRI+LS+WNP DLK MALPPCHMFAQF+V+NGELSCQMYQRS DMGLGVPFNI
Sbjct: 364 IKNKPDDRRIVLSSWNPADLKQMALPPCHMFAQFYVSNGELSCQMYQRSCDMGLGVPFNI 423

Query: 446 ASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKD 505
           ASYALLTCMIAHVC+L PGDFVHV+GDAHVY NHV PL+EQL N+PKPFP LKI +  KD
Sbjct: 424 ASYALLTCMIAHVCDLAPGDFVHVLGDAHVYTNHVDPLKEQLENVPKPFPILKIATSNKD 483

Query: 506 IDSFVAADFKLVGYNPHQK 524
           IDSF A DF+LV Y  HQ+
Sbjct: 484 IDSFTAKDFQLVDYESHQR 502


>D8QVP4_SELML (tr|D8QVP4) Putative uncharacterized protein OS=Selaginella
           moellendorffii GN=SELMODRAFT_404548 PE=3 SV=1
          Length = 502

 Score =  676 bits (1743), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 318/499 (63%), Positives = 383/499 (76%), Gaps = 20/499 (4%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           R +QVVVAAT+D+GIGK+GKLPW + +D+ FFK IT+  +D  KKNA+VMGR+TWESIP 
Sbjct: 17  RAFQVVVAATRDLGIGKEGKLPWSVPSDMAFFKRITSEAADARKKNAVVMGRRTWESIPA 76

Query: 86  KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 145
           K+RPLPGR+NVVL+R+G  ++G  +  ++C S+          P+  S+E VFVIGGG++
Sbjct: 77  KFRPLPGRVNVVLSRAG-LELG--DKAIVCSSLDSALGILAAPPFDSSVEAVFVIGGGEV 133

Query: 146 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 205
           FRE + +P C AIH TEI    ECDTFMP +D T ++LWY+S P   N++R+SF TYVR 
Sbjct: 134 FREAMVSPLCTAIHLTEIQTFFECDTFMPALDLTCFRLWYASSPATVNNVRHSFHTYVRN 193

Query: 206 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 265
           ++    +++            SL         +PE + +RHEEY YL LI++II      
Sbjct: 194 KALDVRNVAGTC---------SLP--------IPEFVRERHEEYQYLNLIKDIIETGNTR 236

Query: 266 XXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIH 325
                   +SKFGCQMRFNLR SFPLLTTK+VFWRGVVEELLWFISGSTNAKVL++KGIH
Sbjct: 237 SDRTGTGTISKFGCQMRFNLRNSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLEDKGIH 296

Query: 326 IWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINK 385
           IW GN SREYLDSIGL+EREE DLGPVYGFQWRHFGARYS MH DY+GQG DQL +VI+K
Sbjct: 297 IWKGNGSREYLDSIGLSEREENDLGPVYGFQWRHFGARYSTMHDDYTGQGVDQLAEVIDK 356

Query: 386 IKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNI 445
           IK+ P+DRRI+LS+WNP DLK MALPPCHMFAQF+V+NGELSCQMYQRS DMGLGVPFNI
Sbjct: 357 IKNKPDDRRIVLSSWNPADLKQMALPPCHMFAQFYVSNGELSCQMYQRSCDMGLGVPFNI 416

Query: 446 ASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKD 505
           ASYALLTCMIAHVC+L PGDFVHV+GDAHVY NHV PL+EQL N+PKPFP LKI +  KD
Sbjct: 417 ASYALLTCMIAHVCDLAPGDFVHVLGDAHVYTNHVDPLKEQLENVPKPFPILKIATSNKD 476

Query: 506 IDSFVAADFKLVGYNPHQK 524
           IDSF A DF+LV Y  HQ+
Sbjct: 477 IDSFTAKDFQLVDYESHQR 495


>B9HRK6_POPTR (tr|B9HRK6) Dihydrofolate reductase-thymidylate synthase OS=Populus
           trichocarpa GN=DHFR-TS-2 PE=3 SV=1
          Length = 414

 Score =  658 bits (1698), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 303/396 (76%), Positives = 344/396 (86%)

Query: 129 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSF 188
           PY LSIEKVFVIGGGQI RE LNAPGC+AIH TEI    +CDTF+P +D++ +Q W SSF
Sbjct: 12  PYFLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVFQPWCSSF 71

Query: 189 PKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEE 248
           PK+ENDIRY F TYVRV+SSA ES SQ      D NS++ KFEV+ F FLP+M+ +RHEE
Sbjct: 72  PKMENDIRYCFTTYVRVRSSAIESHSQKNGVSSDGNSENSKFEVKKFSFLPKMVFERHEE 131

Query: 249 YMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLW 308
           Y+YLRL+Q+II++            LSKFGCQMRFNLR++FP LTTKKVFWRGVVEELLW
Sbjct: 132 YLYLRLVQDIITDGNLKDGRAGTGTLSKFGCQMRFNLRKTFPFLTTKKVFWRGVVEELLW 191

Query: 309 FISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           FISGSTNAKVLQEKGIHIWDGNASR+YLDS+GL +REEGDLGP YGFQWRHFGARY+DMH
Sbjct: 192 FISGSTNAKVLQEKGIHIWDGNASRDYLDSVGLKDREEGDLGPFYGFQWRHFGARYTDMH 251

Query: 369 KDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSC 428
            DY+GQG+DQLLDVI+KI++NPNDR I+LSAWNP DLKLM LPPCHMF QF+VANGELSC
Sbjct: 252 ADYTGQGFDQLLDVIDKIRNNPNDRGIVLSAWNPTDLKLMVLPPCHMFVQFYVANGELSC 311

Query: 429 QMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLL 488
           QMYQRSADMGLGVPF+IASYALLT +IAHVC+LVPGDF+HVIGDAHVYH H+RPLQEQL 
Sbjct: 312 QMYQRSADMGLGVPFSIASYALLTHIIAHVCDLVPGDFIHVIGDAHVYHTHIRPLQEQLH 371

Query: 489 NLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
            LPKPFP LKINSEKKDIDSFVAADF+L+GY+PHQK
Sbjct: 372 KLPKPFPILKINSEKKDIDSFVAADFELIGYDPHQK 407


>A9RXS0_PHYPA (tr|A9RXS0) Predicted protein OS=Physcomitrella patens subsp.
           patens GN=PHYPADRAFT_120817 PE=3 SV=1
          Length = 520

 Score =  658 bits (1697), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 321/503 (63%), Positives = 377/503 (74%), Gaps = 20/503 (3%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           R +Q+VVAAT++ GIGK G LPW+L TD+KFFK +T+ T+   KKNA++MGR TWESIP 
Sbjct: 27  RGFQIVVAATRERGIGKQGHLPWKLPTDMKFFKTVTSVTTSSSKKNAVIMGRHTWESIPE 86

Query: 86  KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 145
           K+RPLPGRLNV+LTRSG     T   VV+  S+           Y   +E VFVIGGGQ+
Sbjct: 87  KFRPLPGRLNVILTRSGIKS--TPAGVVVSESLQSALALIATPSYSSHVESVFVIGGGQL 144

Query: 146 FR----EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
                 E + +P CE IH TE+   +ECDT+MP VD+  +++W +S P VEN +R SF T
Sbjct: 145 VSTVCSEAMASPLCEVIHLTEVEGDVECDTYMPAVDTDIFRIWSASIPIVENGLRISFLT 204

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           YVR   S   S+ Q      DN   ++         LP+ +L+ H+EY YL LI +II  
Sbjct: 205 YVR--GSLTSSIKQT-----DNGETTV-------GLLPKYLLEAHDEYQYLNLIDDIIKT 250

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       +SKFGCQMRFNLR+SFPLLTTK+VFWRGVVEELLWFISGSTNAKVL +
Sbjct: 251 GAVKGDRTGTGTISKFGCQMRFNLRKSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLHD 310

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KG+ IWDGN SREYLD  GLTEREEGDLGPVYGFQWRHFGA+Y DMH DY+GQGYDQL D
Sbjct: 311 KGVKIWDGNGSREYLDKQGLTEREEGDLGPVYGFQWRHFGAKYVDMHADYTGQGYDQLKD 370

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VINKIK +P+DRRI+LSAWNP DLKLMALPPCHMFAQF+VANGELSCQMYQRS DMGLGV
Sbjct: 371 VINKIKTDPDDRRILLSAWNPADLKLMALPPCHMFAQFYVANGELSCQMYQRSCDMGLGV 430

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASYALLTC++AHVC+LVPGDFVHV+GDAHVY NHV PLQEQL N P PFP L+I +
Sbjct: 431 PFNIASYALLTCILAHVCDLVPGDFVHVLGDAHVYKNHVEPLQEQLQNTPMPFPRLRIKT 490

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
             +DIDSFVAADF+L+GY  HQK
Sbjct: 491 ANRDIDSFVAADFELIGYKAHQK 513


>Q01FK1_OSTTA (tr|Q01FK1) Bifunctional dihydrofolate reductase-thymidylate
           synthase 2 / DHFR-TS (ISS) OS=Ostreococcus tauri
           GN=Ot01g05780 PE=3 SV=1
          Length = 751

 Score =  618 bits (1594), Expect = e-174,   Method: Compositional matrix adjust.
 Identities = 298/507 (58%), Positives = 352/507 (69%), Gaps = 26/507 (5%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           R +QVVVAAT D GIGKD  LPW+L  D+  FK++T+ T D    NA+VMGRKTWESIP 
Sbjct: 256 RAFQVVVAATVDGGIGKDNGLPWKLTKDMGHFKKLTSETRDANAVNAVVMGRKTWESIPA 315

Query: 86  KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLS--------IEKV 137
           K+RPLPGRLNVVL+RSG       EN     ++             LS        +EK 
Sbjct: 316 KFRPLPGRLNVVLSRSGVLAEANDENNNGAETLPEGVLVRKTIDDALSAISSSEKRVEKT 375

Query: 138 FVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
           FVIGG QI+ E L +  CEA+H TE+    ECD F+P +D+ K++L+  S P  EN  RY
Sbjct: 376 FVIGGAQIYEEALKSERCEAVHLTEVEGDFECDVFIPKIDADKFKLYGQSKPITENGARY 435

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
            F TYV                    +S+S KF     + LP     +HEE+ YL +I+E
Sbjct: 436 QFLTYV------------------TKDSESGKFRPIAGELLPAGCDVKHEEHQYLDMIRE 477

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           II +            +S FG QMRF+LRRSFPLLTTK+VFWRGV EELLWF++G TNA 
Sbjct: 478 IIDQGAVKGDRTGTGTISTFGNQMRFDLRRSFPLLTTKRVFWRGVAEELLWFVAGETNAN 537

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L EK I+IWDGN SREYLDSIGLTERE GDLGPVYGFQWRHFGA Y++MH DY+G+G D
Sbjct: 538 KLAEKKINIWDGNGSREYLDSIGLTEREVGDLGPVYGFQWRHFGAEYTNMHADYTGKGVD 597

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VINKIK+NP DRRI+L+AWNP  LK MALPPCHMF QF+VANGELSCQMYQRS DM
Sbjct: 598 QLAEVINKIKNNPTDRRILLTAWNPAALKEMALPPCHMFCQFYVANGELSCQMYQRSCDM 657

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASY+LLTCMIA VC+L PGDFVHV GD HVY NHV PL++QL   P+PFP L
Sbjct: 658 GLGVPFNIASYSLLTCMIAQVCDLKPGDFVHVCGDTHVYSNHVEPLKKQLTCEPRPFPIL 717

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
           KIN EKKDIDSF   DF+++GY+PH K
Sbjct: 718 KINPEKKDIDSFTFDDFEIIGYDPHPK 744


>A4RXM1_OSTLU (tr|A4RXM1) Predicted protein OS=Ostreococcus lucimarinus (strain
           CCE9901) GN=OSTLU_49676 PE=3 SV=1
          Length = 499

 Score =  612 bits (1578), Expect = e-172,   Method: Compositional matrix adjust.
 Identities = 295/505 (58%), Positives = 354/505 (70%), Gaps = 26/505 (5%)

Query: 28  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 87
           +QVVVAAT++ GIG++  LPWRL  D+ +FK+IT+ T D    NA+VMGRKTWESIP K+
Sbjct: 6   FQVVVAATREGGIGRENALPWRLAGDMGYFKKITSETRDGDAMNAVVMGRKTWESIPGKF 65

Query: 88  RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLS--------IEKVFV 139
           RPLPGRLN+VL+RSG       EN     ++             LS        IEK FV
Sbjct: 66  RPLPGRLNIVLSRSGGLAEANDENNNGAETLPEGVLVRKSIDDALSAISSSEKRIEKTFV 125

Query: 140 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSF 199
           IGG QI+ E L +  CEA+H TE+    ECD F+P +D+TK++L+  S P +E   R+ F
Sbjct: 126 IGGAQIYEEALQSEKCEAVHLTEVEGEFECDAFIPKIDATKFKLYGQSKPMIEKGTRFQF 185

Query: 200 ATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEII 259
            TYV                    +++S KF  +  + LP     +HEEY YL +I+EII
Sbjct: 186 LTYVTA------------------DAESGKFRPKADEVLPAGCSIKHEEYQYLEMIREII 227

Query: 260 SEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVL 319
            +            +S FG QMRF+LRRSFPLLTTK+VFWRGV EELLWF++G TNA  L
Sbjct: 228 DQGAVKGDRTGTGTISTFGNQMRFDLRRSFPLLTTKRVFWRGVAEELLWFVAGETNANKL 287

Query: 320 QEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQL 379
            EK I+IWDGN SREYLDSIGLTERE GDLGPVYGFQWRHFGA Y++MH DY+G+G DQL
Sbjct: 288 AEKKINIWDGNGSREYLDSIGLTEREVGDLGPVYGFQWRHFGAEYTNMHADYTGKGVDQL 347

Query: 380 LDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGL 439
            +VI+KIK+NPNDRRI+L+AWNP  LK MALPPCHMF QF+VANGELSCQMYQRS DMGL
Sbjct: 348 AEVIHKIKNNPNDRRILLTAWNPAALKEMALPPCHMFCQFYVANGELSCQMYQRSCDMGL 407

Query: 440 GVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKI 499
           GVPFNIASY+LLTCMIA VC L PGDFVH  GD HVY NHV PL++QL   P+PFP LKI
Sbjct: 408 GVPFNIASYSLLTCMIAQVCGLKPGDFVHCCGDTHVYSNHVEPLEKQLACEPRPFPILKI 467

Query: 500 NSEKKDIDSFVAADFKLVGYNPHQK 524
           N EKKDIDSF   DF++VGY+PH K
Sbjct: 468 NPEKKDIDSFTFDDFEIVGYDPHPK 492


>C1MMA6_MICPC (tr|C1MMA6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Micromonas pusilla (strain CCMP1545)
           GN=DHFR-TS PE=3 SV=1
          Length = 524

 Score =  598 bits (1541), Expect = e-168,   Method: Compositional matrix adjust.
 Identities = 294/526 (55%), Positives = 361/526 (68%), Gaps = 45/526 (8%)

Query: 26  RTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           R +QVVVAATK DMGIG DG LPWRL  D+ +FK +T   ++PGK+NA++MGRKTWESIP
Sbjct: 10  RPFQVVVAATKGDMGIGLDGALPWRLPKDMAYFKSVTATVAEPGKRNAVIMGRKTWESIP 69

Query: 85  LKYRPLPGRLNVVLTRSGSF-----------DIGTAENVV-----ICGSIXXXXXXXXXX 128
            K+RPLPGRLNVVL++SG+              GT  NV+     +  S+          
Sbjct: 70  AKFRPLPGRLNVVLSKSGALVESTGSENAAPANGTPSNVLPPSVLLQPSLEAALATLGAG 129

Query: 129 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHA------SIECDTFMPPVDSTKYQ 182
            +  ++EK+FV+GG Q++ E + +P C+A+H TE+        + +CDT MPPVD  K++
Sbjct: 130 EHAENVEKIFVVGGAQVYAEAMASPACQAVHITEVTPPKDTPDAFKCDTHMPPVDMEKFK 189

Query: 183 LWYSSFPKVEND-IRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
           L+ S+ P  E +  +  F +YV   ++                    KF +     LP  
Sbjct: 190 LYASAPPVNEKEGAKIQFLSYVAKDAATG------------------KFRIPGSVSLPPG 231

Query: 242 ILQ---RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVF 298
            +    RHEE  YL LI++II              +SKFG  MRF+LRRSFPLLTTK+VF
Sbjct: 232 AVANGVRHEELQYLDLIRDIIESGNVKGDRTGTGTISKFGTSMRFDLRRSFPLLTTKRVF 291

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNAK LQ+K IHIWDGN SREYLDS+GL+ REE DLGPVYGFQWR
Sbjct: 292 WRGVAEELLWFVGGRTNAKELQDKDIHIWDGNGSREYLDSVGLSHREEQDLGPVYGFQWR 351

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y+DMH +Y G+G DQL +VI+KIK+NPNDRRI+L+AWNP  LK MALPPCHMF Q
Sbjct: 352 HFGAEYTDMHANYDGKGVDQLAEVIDKIKNNPNDRRILLTAWNPAALKEMALPPCHMFCQ 411

Query: 419 FFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHN 478
           F+VANGELSCQMYQRS DMGLGVPFNIASY+LLTCMIA VC L PGDFVHV+GD HVY N
Sbjct: 412 FYVANGELSCQMYQRSCDMGLGVPFNIASYSLLTCMIAQVCGLKPGDFVHVMGDTHVYSN 471

Query: 479 HVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           HV PL++QLL  P+PFPTLKIN  K DIDSF  +DF + GY+PH K
Sbjct: 472 HVEPLKKQLLCEPRPFPTLKINPAKTDIDSFEFSDFTIEGYDPHPK 517


>E1ZCI9_CHLVA (tr|E1ZCI9) Putative uncharacterized protein OS=Chlorella
           variabilis GN=CHLNCDRAFT_30873 PE=3 SV=1
          Length = 508

 Score =  596 bits (1536), Expect = e-168,   Method: Compositional matrix adjust.
 Identities = 287/519 (55%), Positives = 349/519 (67%), Gaps = 45/519 (8%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           +RT Q+VVAATK  GIGK G LPW L  D+K+F+E+T+ T+DP K+N ++MGRKTWESIP
Sbjct: 7   RRTIQIVVAATKQWGIGKGGSLPWSLPGDMKYFRELTSRTADPAKQNVVIMGRKTWESIP 66

Query: 85  LKYRPLPGRLNVVLTR----------------SGSFDIGTAENVVICGSIXXXXXXXXXX 128
            K+RPL GR+NVVLTR                +   +   AE V I  S+          
Sbjct: 67  AKFRPLAGRINVVLTRGAVAGDENASAPGNATAALAEASKAEGVHISSSLDSALEMLSGP 126

Query: 129 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFT----EIHASIECDTFMPPVDSTKYQLW 184
            +   +E VFVIGGGQ+++E + +P   AIH T    E   +  CDTFMPPVD ++++LW
Sbjct: 127 EFDSRVESVFVIGGGQVYKECMESPLLSAIHLTLVEGEAAEAANCDTFMPPVDESRFRLW 186

Query: 185 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 244
            +S P+     RYSF  Y R                            +    LP  +  
Sbjct: 187 SASAPRSVGGTRYSFLCYTRAGQ-------------------------EGLPALPPTVAS 221

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           RHEE+ YL +I+++++              SKFG  MRFNLR SFPLLTTK+VFWRGV E
Sbjct: 222 RHEEHQYLEMIEDVMANGVFRGDRTGTGTYSKFGATMRFNLRHSFPLLTTKRVFWRGVAE 281

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWF+SG TNA+VL +KGIHIWDGN SREYLDSIGL+ REE DLGPVYGFQWRHFGA Y
Sbjct: 282 ELLWFVSGCTNARVLMDKGIHIWDGNGSREYLDSIGLSHREEMDLGPVYGFQWRHFGAEY 341

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
           +DMH DY G+G DQL ++I+KIK NPNDRR++LSAWNP  L  MALPPCHMF QF+VA+G
Sbjct: 342 TDMHADYGGKGVDQLAELIHKIKTNPNDRRLVLSAWNPAALTDMALPPCHMFCQFYVADG 401

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQMYQRS D+GLGVPFNIASY+LLTCM+A VC L PGDFVHV+GDAHVY NHV PL+
Sbjct: 402 ELSCQMYQRSCDLGLGVPFNIASYSLLTCMVAQVCGLRPGDFVHVLGDAHVYANHVGPLR 461

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
           +QL N P+ FP L IN  K DIDSFV  DF+L GY PH+
Sbjct: 462 DQLKNAPRHFPRLLINPAKTDIDSFVFDDFQLEGYQPHK 500


>M0S7X1_MUSAM (tr|M0S7X1) Uncharacterized protein OS=Musa acuminata subsp.
           malaccensis PE=4 SV=1
          Length = 505

 Score =  591 bits (1524), Expect = e-166,   Method: Compositional matrix adjust.
 Identities = 294/501 (58%), Positives = 355/501 (70%), Gaps = 22/501 (4%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QRTYQVVVAAT+DMGIGKDG LPW+L +DLKFFKE+T  TSDP K+NA++MGRKTWESIP
Sbjct: 19  QRTYQVVVAATRDMGIGKDGNLPWKLPSDLKFFKEVTMTTSDPSKRNAVIMGRKTWESIP 78

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
            + RPLPGRLNVVLTRSGSFDI TAEN+++CGS+          PYCLSIE+VFVIGGGQ
Sbjct: 79  PRNRPLPGRLNVVLTRSGSFDIATAENILMCGSLNSALELLAATPYCLSIERVFVIGGGQ 138

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LNAPGCEAIH T+I  S +CDTF+PPVD + ++ WYSSFP +EN IRYSF TYVR
Sbjct: 139 VLREALNAPGCEAIHLTDIETSFQCDTFIPPVDCSVFRPWYSSFPLLENSIRYSFVTYVR 198

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYL-RLIQEIISEXX 263
           +      SL       +      L   +++   +  + L R    M L R+I++ +    
Sbjct: 199 I------SLRLRGSCFY------LSLFMKDMKNMHILGLSRISLQMVLERMIEQGLGHYL 246

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG 323
                        F C      R  F  ++ K      VV+++  F         +    
Sbjct: 247 NLVVRCGLICGDLFHCSQP---REFFGEVSLKNSCGLLVVQQMQRFCREKAFIYGMAMHQ 303

Query: 324 IHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
            +   G      +D +GLT REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G+DQL  +I
Sbjct: 304 ENTLTG------MDFVGLTHREEGDLGPVYGFQWRHFGAEYTDMHADYTGEGFDQLSAII 357

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           +KIK++P+DRR+ILSAWNP DLK MALPPCHMFAQF+V NGELSCQMYQRSAD+GLGVPF
Sbjct: 358 DKIKNDPDDRRMILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADLGLGVPF 417

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           NIASY+LLTCMIA VC+L+PGDFVH IGDAHVY  HVRPL+EQL   PKPFP LK+N  K
Sbjct: 418 NIASYSLLTCMIAQVCDLLPGDFVHAIGDAHVYSTHVRPLEEQLQKQPKPFPVLKMNPLK 477

Query: 504 KDIDSFVAADFKLVGYNPHQK 524
           KDIDSFVA+DF+LVGY+PH K
Sbjct: 478 KDIDSFVASDFELVGYDPHSK 498


>C1E6F7_MICSR (tr|C1E6F7) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Micromonas sp. (strain RCC299 / NOUM17)
           GN=DHFR-TS PE=3 SV=1
          Length = 523

 Score =  590 bits (1521), Expect = e-166,   Method: Compositional matrix adjust.
 Identities = 294/526 (55%), Positives = 354/526 (67%), Gaps = 45/526 (8%)

Query: 26  RTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           R +QVVVAATK +MGIG  G LPW L  D+ +FK +T+  ++PG KNA+VMGRKTWESIP
Sbjct: 9   RPFQVVVAATKGEMGIGYQGGLPWNLPKDMAYFKAVTSQVNEPGTKNAVVMGRKTWESIP 68

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAEN----------------VVICGSIXXXXXXXXXX 128
            K+RPLPGR+NVVL+R  +     +EN                V +  S+          
Sbjct: 69  AKFRPLPGRVNVVLSRGHTLVEAGSENSAPVNGGGKPEVLPEGVFLRPSLEAALELLSAP 128

Query: 129 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIE------CDTFMPPVDSTKYQ 182
            +   +EKVFVIGG Q++ E + +P C+A+H TE+    +      CD F+P +D  K++
Sbjct: 129 EHEAGVEKVFVIGGAQVYAEAMASPHCQALHLTEVTPPADEPEKYKCDAFLPQIDPAKFK 188

Query: 183 LWYSSFPKVEND-IRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 241
           L+ S+ P  E D     F TY                  F  +  + KF       LP  
Sbjct: 189 LYASAKPLREKDGATIQFLTY------------------FGVDPGTGKFRSPGSKVLPAG 230

Query: 242 ILQ---RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVF 298
            +    RHEE  YL LI+EI+ E            +SKFGCQMRF+LRRSFPLLTTK+VF
Sbjct: 231 AVAKGVRHEEMQYLDLIKEIMEEGNVKGDRTGTGTISKFGCQMRFDLRRSFPLLTTKRVF 290

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EEL+WF+ G T+AK LQ+K IHIWDGN SREYLDS+GL  REEGDLGPVYGFQWR
Sbjct: 291 WRGVAEELIWFVKGCTSAKELQDKDIHIWDGNGSREYLDSVGLGHREEGDLGPVYGFQWR 350

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y DMH DY+GQG DQL +VI+KIK+NPNDRRI+L+AWNP  LK MALPPCHMF Q
Sbjct: 351 HFGAEYKDMHADYTGQGVDQLAEVIDKIKNNPNDRRILLTAWNPAALKEMALPPCHMFCQ 410

Query: 419 FFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHN 478
           F+VANGELSCQMYQRS DMGLGVPFNIASY+LLTCM+A VC L PGDFVH  GD HVY N
Sbjct: 411 FYVANGELSCQMYQRSCDMGLGVPFNIASYSLLTCMVAQVCGLKPGDFVHCCGDTHVYSN 470

Query: 479 HVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           HV PL +QL N P+PFPTLKIN EKKDIDSF  +DF++V Y+PH K
Sbjct: 471 HVEPLYKQLENEPRPFPTLKINPEKKDIDSFEFSDFEIVDYDPHPK 516


>I0YVC8_9CHLO (tr|I0YVC8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Coccomyxa subellipsoidea C-169
           GN=COCSUDRAFT_37014 PE=3 SV=1
          Length = 479

 Score =  578 bits (1489), Expect = e-162,   Method: Compositional matrix adjust.
 Identities = 282/500 (56%), Positives = 340/500 (68%), Gaps = 34/500 (6%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           Q T+Q+VVAAT+ +GIGK G +PW+L  D+ +FKE+TT T+DP  +NA+VMGRKTWESIP
Sbjct: 7   QLTFQIVVAATRKLGIGKGGTMPWKLPGDMAYFKELTTRTADPNNQNAVVMGRKTWESIP 66

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
            K+RPLPGR+NVVL+R               GS+           +   IE VFVIGGG+
Sbjct: 67  PKFRPLPGRVNVVLSRGS------------VGSLEAAMALLGETSFKERIETVFVIGGGK 114

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           ++ E L +P C A+HFT I A IECDTF P +   K++LW  S P+   D+RYSF  YV 
Sbjct: 115 VYEEALPSPLCSAVHFTAIEADIECDTFFPEMSLDKWRLWSESAPRRNGDMRYSFQCYVP 174

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
             +S++ S                             +  +HEE  YL ++ +II     
Sbjct: 175 ASASSSSSPPALP----------------------PAVAAQHEELQYLNMVDDIIRNGVF 212

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                     +KFGCQMRFNLR +FPLLTTK+ FWRGVVEELLWFISGSTNA VL+ KG+
Sbjct: 213 RGDRTGTGTFTKFGCQMRFNLRHTFPLLTTKRTFWRGVVEELLWFISGSTNANVLKAKGV 272

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
            IWDGN SREYLDSIGL  REEGDLGPVYGFQWRHFGA Y+DMH DY+G+G DQL  +I 
Sbjct: 273 GIWDGNGSREYLDSIGLNHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGVDQLAALIA 332

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
            IK  P DRR +L+AWNP  L  MALPPCH+F QFFVA GELSCQMYQRS D+GLGVPFN
Sbjct: 333 GIKAKPYDRRHVLTAWNPAALPDMALPPCHLFCQFFVAEGELSCQMYQRSCDLGLGVPFN 392

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASYALLT +IA VC L PG+ VHV+GDAHVY NHV PL+EQL N P+ FP LK+N  K 
Sbjct: 393 IASYALLTRIIAQVCGLQPGELVHVLGDAHVYANHVDPLKEQLKNAPRAFPVLKVNPAKS 452

Query: 505 DIDSFVAADFKLVGYNPHQK 524
           DID+FV  DF+L+ Y PH+K
Sbjct: 453 DIDNFVYEDFELLHYEPHKK 472


>K8ECA8_9CHLO (tr|K8ECA8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Bathycoccus prasinos GN=Bathy03g03500 PE=3
           SV=1
          Length = 528

 Score =  574 bits (1479), Expect = e-161,   Method: Compositional matrix adjust.
 Identities = 291/535 (54%), Positives = 354/535 (66%), Gaps = 48/535 (8%)

Query: 20  PLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKT 79
           P  +  + +QVVVA+ +  GIGK+  LPW+L  ++K FK +T   S P  +NA++MGRKT
Sbjct: 5   PTKDDLKKFQVVVASDELGGIGKNQTLPWKLSKEMKHFKSLTADVSKPMTQNAVIMGRKT 64

Query: 80  WESIPLKYRPLPGRLNVVLTRSGS-FDIGTAEN------------------VVICGSIXX 120
           WESIP K+RPLPGRLNVVL+ SG  ++    EN                  V+   SI  
Sbjct: 65  WESIPEKFRPLPGRLNVVLSASGRVYEKSNKENGGPGEDDAEGGAKCLPEGVLARASIEE 124

Query: 121 XXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIH--------ASIECDTF 172
                    Y   IEKVFVIGG +++ E L +  CEA+H TE+             CD F
Sbjct: 125 ALETLSTGEYKDIIEKVFVIGGAKVYEEALKSEQCEAVHLTEVKPPAGKDPKEHFACDAF 184

Query: 173 MP-PVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFE 231
           +P P+DS K++L+ SS    + +  Y+  TYV                    N  + KF 
Sbjct: 185 IPLPLDSEKFRLYSSSKLVKDGECSYTTLTYVA------------------QNGPAGKFR 226

Query: 232 VQNFDFLPEMIL--QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSF 289
           V+    LP  IL  Q+HEE  YL LI+EII E            +SKFGC MR++LRRSF
Sbjct: 227 VEAEKILPPKILKEQKHEEMQYLELIREIIDEGNVKGDRTGTGTISKFGCSMRYDLRRSF 286

Query: 290 PLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDL 349
           PLLT+K+VFWRGV EELLWF+ GSTNA  L+EKG+ IWDGN SREYLDSIGL  RE  DL
Sbjct: 287 PLLTSKRVFWRGVAEELLWFVKGSTNANELKEKGVGIWDGNGSREYLDSIGLNHREVNDL 346

Query: 350 GPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMA 409
           GPVYGFQWRHF A Y+DMH DY+G+G DQL +VI+KIK+NPNDRRI+L+AWNP  LK MA
Sbjct: 347 GPVYGFQWRHFNAEYTDMHADYAGKGVDQLAEVIHKIKNNPNDRRILLTAWNPAALKEMA 406

Query: 410 LPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHV 469
           LPPCHMF QF+VANGELSCQMYQRS DMGLGVPFNIASY+LLTCMIA VC+L PGDFVHV
Sbjct: 407 LPPCHMFCQFYVANGELSCQMYQRSCDMGLGVPFNIASYSLLTCMIAQVCDLKPGDFVHV 466

Query: 470 IGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           +GDAHVY NHV PL+ QL N P+PFP LKIN + KDID F   DF+++GY+P  K
Sbjct: 467 LGDAHVYANHVEPLETQLKNEPRPFPQLKINPDVKDIDGFKFEDFEIIGYDPCPK 521


>A8JD96_CHLRE (tr|A8JD96) Predicted protein OS=Chlamydomonas reinhardtii
           GN=CHLREDRAFT_139742 PE=3 SV=1
          Length = 478

 Score =  546 bits (1406), Expect = e-152,   Method: Compositional matrix adjust.
 Identities = 264/500 (52%), Positives = 337/500 (67%), Gaps = 35/500 (7%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLP-WRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 83
           ++ +Q+V+AAT  +GIGK+GKLP W+L  D+ +FKE+T+ T D    NA++MGRKTWESI
Sbjct: 5   RKGFQLVIAATPSLGIGKNGKLPDWQLPGDMAYFKELTSRTRDGAHTNAVIMGRKTWESI 64

Query: 84  PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
           P K+RPL GRLN+VL+RS + D    E+ +                    +E VF+IGGG
Sbjct: 65  PAKFRPLKGRLNIVLSRSFADDADLLESALSLLEHKELKG---------GVEGVFIIGGG 115

Query: 144 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 203
           Q++ E L  P C A+H T++    ECDTF+P +D   + +W SS P  EN+ RYSF  Y 
Sbjct: 116 QVYAEALAHPNCTAVHLTQVEKEYECDTFLPALDPAVWGVWSSSEPVTENNTRYSFVCYT 175

Query: 204 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXX 263
           R  +  A  L                         P  +  RH+E  YL L++E+I+   
Sbjct: 176 RRGTEQAPEL-------------------------PPCMASRHDEQQYLELVRELITSGV 210

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG 323
                      S+FG   R+NLR +FPLLT+K+VFW+GV EELLWFISG+TNA +L++K 
Sbjct: 211 FRPDRTGTGTYSRFGRTSRYNLRHTFPLLTSKRVFWKGVAEELLWFISGATNANLLRDKN 270

Query: 324 IHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
           IHIWDGN+SRE+LD  GL  RE GDLGPVYGFQWRHFGA Y DMH DY+G+G DQL  +I
Sbjct: 271 IHIWDGNSSREFLDGRGLGHREVGDLGPVYGFQWRHFGAEYKDMHTDYTGKGVDQLRYII 330

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           + +K +PNDRR+++SAWNP  L  MALPPCHMF QF+VA+GELSC MYQRS D+GLGVPF
Sbjct: 331 DTLKKDPNDRRMVMSAWNPAALAEMALPPCHMFCQFYVADGELSCLMYQRSCDVGLGVPF 390

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           NIASYALLT ++A V  L  G+ VHV+GD HVY NHV PL+EQL N P+ FPTL+IN +K
Sbjct: 391 NIASYALLTRLVAQVTGLRAGELVHVMGDTHVYANHVEPLREQLKNTPRHFPTLRINPDK 450

Query: 504 KDIDSFVAADFKLVGYNPHQ 523
           KDIDSFV  DF+LV YNPH+
Sbjct: 451 KDIDSFVFEDFELVDYNPHK 470


>D8UB22_VOLCA (tr|D8UB22) Putative uncharacterized protein OS=Volvox carteri
           GN=VOLCADRAFT_66296 PE=3 SV=1
          Length = 483

 Score =  538 bits (1386), Expect = e-150,   Method: Compositional matrix adjust.
 Identities = 259/500 (51%), Positives = 330/500 (66%), Gaps = 29/500 (5%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLP-WRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 83
            + +Q+VVAAT  +GIGK+G LP W+L  D+ +F+E+T+ T +P  +N  +MGRKTWESI
Sbjct: 4   HKGFQLVVAATPSLGIGKNGTLPGWKLPGDMAYFRELTSRTREPSCQNVAIMGRKTWESI 63

Query: 84  PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
           P K+RPL GR+N++  R+G+       +V+ C S+               ++ VFVIGG 
Sbjct: 64  PNKFRPLKGRINIIARRNGA---QFGPDVLGCSSLGAALELLEDEKLKRDVDFVFVIGGA 120

Query: 144 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 203
           Q++ E L  P C A+H T++    +CD  +PP+D + + +W +S P  END RYSF  Y 
Sbjct: 121 QVYAEALRHPSCTAVHLTKVEKEFDCDAHLPPLDPSVFGVWSASEPFQENDTRYSFVCYT 180

Query: 204 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXX 263
           R   S                             LP  +  RH+E  YL L++E+I+   
Sbjct: 181 RRGLSPPPE-------------------------LPPGMASRHDEIQYLELVRELITSGT 215

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG 323
                      S+FG   R+NLR +FPLLT+K+VFW+GV EELLWFI GSTNA +L++K 
Sbjct: 216 FRPDRTGTGTYSRFGRTARYNLRHTFPLLTSKRVFWKGVAEELLWFIRGSTNANLLRDKN 275

Query: 324 IHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
           IHIWDGN++REYLDS GL  RE GDLGPVYGFQWRHFGA Y DMH DY+GQG DQL  +I
Sbjct: 276 IHIWDGNSTREYLDSRGLHHREVGDLGPVYGFQWRHFGAAYKDMHTDYTGQGVDQLKAII 335

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
            +I+ +PNDRR+I+SAWNP  L  MALPPCHMF QF+VA+GELSC MYQRS D+GLGVPF
Sbjct: 336 EQIRKDPNDRRMIMSAWNPAALNEMALPPCHMFCQFYVADGELSCLMYQRSCDVGLGVPF 395

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           NIASYALLT ++A V  L  GDF+HV+GD HVY NHV PL+EQL N P+ FP L IN  K
Sbjct: 396 NIASYALLTRLVAQVTGLRAGDFIHVMGDTHVYANHVEPLKEQLKNTPRHFPILNINPAK 455

Query: 504 KDIDSFVAADFKLVGYNPHQ 523
            DIDSFV  DF+LV Y PHQ
Sbjct: 456 TDIDSFVFEDFELVDYQPHQ 475


>Q9SIK4_ARATH (tr|Q9SIK4) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Arabidopsis thaliana GN=AT2G21550 PE=3 SV=1
          Length = 492

 Score =  536 bits (1382), Expect = e-150,   Method: Compositional matrix adjust.
 Identities = 263/494 (53%), Positives = 347/494 (70%), Gaps = 25/494 (5%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           +R+YQVV+AAT+DMG+G D KLPW L ++ +FF+++TT TSDP K+NA +MGRK+WES P
Sbjct: 21  RRSYQVVIAATRDMGLGMDMKLPWDLPSEYQFFQDVTTRTSDPTKRNATIMGRKSWESTP 80

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           L+ RPLPGRLN+VLT+S   +I   ENV++  S+          PY LSIEKVFVIGGG+
Sbjct: 81  LEIRPLPGRLNIVLTKSSCHNIAIDENVLVSSSMESALELLATEPYSLSIEKVFVIGGGE 140

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + R  +NA  C+AIH TEI  S+ CD F P VD++ Y+ WYSSFP VEN IRYSF TYVR
Sbjct: 141 LLRNYMNASICDAIHLTEIDISVPCDAFAPRVDTSLYRPWYSSFPVVENGIRYSFNTYVR 200

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
            + +   S  + +    D         ++ + FLP+M+ +RHEE+ YL L+Q IIS    
Sbjct: 201 RKDAIVGSGEKKSVAESD---------LKEYSFLPKMVFERHEEFGYLNLVQNIISS--- 248

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR++FPLLTTKK+FW GVVEE+L  ISGS N K   E G 
Sbjct: 249 -GDMNDNSTLSKFGCQMRFNLRKTFPLLTTKKIFWLGVVEEILQLISGSNNPK---ENGS 304

Query: 325 HIWDGNASREYLDSIGLTEREE-GDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
           HIWD + ++EYLDS G+   EE GD   ++G  W+H  AR+         Q + QL DVI
Sbjct: 305 HIWDTDEAKEYLDSFGVNATEEDGDNPFLHGLHWKHCDARFVI-------QEFSQLSDVI 357

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           NKIK+NP+D+RI+L+A NP+D KL ++ PCH F QF+VANGE+SCQ+YQ S +  +G+PF
Sbjct: 358 NKIKNNPHDQRIMLAACNPLDFKL-SVSPCHTFTQFYVANGEVSCQIYQSSTEASIGIPF 416

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           +IA+Y+LLTC+IAHVC+L  GDF+HVIG A++   HV+ +Q+QL   PKPFP LKIN EK
Sbjct: 417 SIATYSLLTCIIAHVCDLGAGDFIHVIGQAYINKAHVKAIQKQLQISPKPFPILKINPEK 476

Query: 504 KDIDSFVAADFKLV 517
           K +D+F A+D +L+
Sbjct: 477 KKMDNFEASDLELM 490


>L1JGV3_GUITH (tr|L1JGV3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Guillardia theta CCMP2712
           GN=GUITHDRAFT_69716 PE=3 SV=1
          Length = 478

 Score =  536 bits (1382), Expect = e-150,   Method: Compositional matrix adjust.
 Identities = 269/506 (53%), Positives = 335/506 (66%), Gaps = 46/506 (9%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATS--DPGKKNAIVMGRKTWESIPLKY 87
           ++VA TK+ GIG+DGKLPW L  D+ +FK++TT  S   P   NA++MGRKTWESIP  +
Sbjct: 1   MIVACTKNGGIGRDGKLPWNLKEDMAWFKKVTTEASADKPEGCNAVIMGRKTWESIPPSF 60

Query: 88  RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 147
           RPL GR+N+VL+RS    +   + VV+  S+               I + FVIGGG+++R
Sbjct: 61  RPLSGRVNIVLSRSPD-SMSVPDGVVLSKSLADAMQVVDSRD---DISQCFVIGGGELYR 116

Query: 148 EVLNAPG-CEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPK------VENDIRYSFA 200
           E +N+   C+ I  T +H   ECDTF+P              PK       +  I+Y F 
Sbjct: 117 EAMNSDRLCKVIFRTLVHGEFECDTFIP-----------CEIPKGFIRDTEDKGIQYEFQ 165

Query: 201 TYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIIS 260
            +VR  ++ + S S+    + +  +                    HEEY YL LI++I+ 
Sbjct: 166 IFVRPATAGSNSHSEMNSHVSNGVA--------------------HEEYQYLNLIRDILQ 205

Query: 261 EXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQ 320
                        + KFG  MRFNLR SFPLLTTK+VFWRGVVEELLWFISG+TNA +L+
Sbjct: 206 TGIRKGDRTGTGTIGKFGASMRFNLRESFPLLTTKRVFWRGVVEELLWFISGATNANLLR 265

Query: 321 EKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLL 380
           EK IHIWDGN S+EYL  IGL  REEGDLGPVYGFQWRHFGA+Y+DMH DY+GQG DQL 
Sbjct: 266 EKDIHIWDGNGSKEYLAKIGLGHREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGVDQLA 325

Query: 381 DVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV--ANGELSCQMYQRSADMG 438
           +VIN IK NPNDRRI+LSAWNP DL +MALPPCHMF QF+V    GELSCQMYQRS DMG
Sbjct: 326 NVINTIKTNPNDRRILLSAWNPADLGIMALPPCHMFCQFYVDTEKGELSCQMYQRSCDMG 385

Query: 439 LGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLK 498
           LGVPFNIASY+LLTC++AHVC L PG+F+H +GD HVY NHV  L+ QL   P+PFP ++
Sbjct: 386 LGVPFNIASYSLLTCLVAHVCNLKPGEFIHTLGDVHVYSNHVEALKIQLEREPRPFPKIR 445

Query: 499 INSEKKDIDSFVAADFKLVGYNPHQK 524
           IN EK+DIDSFV +D  L GY+PH K
Sbjct: 446 INPEKRDIDSFVLSDITLEGYDPHAK 471


>D7LBE8_ARALL (tr|D7LBE8) Predicted protein OS=Arabidopsis lyrata subsp. lyrata
           GN=ARALYDRAFT_667353 PE=4 SV=1
          Length = 490

 Score =  516 bits (1329), Expect = e-144,   Method: Compositional matrix adjust.
 Identities = 264/495 (53%), Positives = 342/495 (69%), Gaps = 25/495 (5%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           +R+YQVV+AAT+DMG+G D KLPW L TD +FF ++TT T+DP ++NA +MGRK+WES P
Sbjct: 19  RRSYQVVIAATRDMGLGMDMKLPWDLPTDSQFFHDVTTRTTDPTRRNATIMGRKSWESTP 78

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           L+ RPLPGRLN+VLT+S   +I   ENV++C S+          PY LSIEKVFVIGGG+
Sbjct: 79  LEIRPLPGRLNIVLTKSSCHNIAIDENVLVCDSMESALELLATEPYSLSIEKVFVIGGGE 138

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + R  +NAP C+AIH TEI  S+ CD F P VD++ Y  WYSSFP VEN IRYSF TYVR
Sbjct: 139 LLRNYMNAPSCDAIHLTEIDISVPCDAFAPRVDTSLYHPWYSSFPIVENGIRYSFNTYVR 198

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
            + +   S  + +    D          + + FLP+M+ +RH+E+ YL LIQ IIS    
Sbjct: 199 RKDAVVGSGEKKSAAGSD---------FKEYSFLPKMVFERHDEFGYLNLIQNIISS--- 246

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    L+KFGCQMRFNLR++FPLLTTKKVFW GVVEE+L  ISGS N     EKG 
Sbjct: 247 -GDMNDNNTLTKFGCQMRFNLRKTFPLLTTKKVFWLGVVEEILQLISGSINP---MEKGS 302

Query: 325 HIWDGNASREYLDSIGLTEREE-GDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
           +IWD + + EYL+S G+   EE GD   +YG QW+H  AR          Q + QL DVI
Sbjct: 303 NIWDSDEANEYLNSFGVNATEEDGDHQHLYGLQWKHTDAR-------LIVQKFSQLSDVI 355

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           NKIK+NP+++RI+LSA NP DLKL ++ PC  FAQF+VANGELS Q+YQ S +  + +PF
Sbjct: 356 NKIKNNPHNQRIMLSACNPSDLKL-SVSPCQTFAQFYVANGELSSQIYQSSTEASIEIPF 414

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           +I +Y+LLTC+IAHVC+LV GDF++VIG A +    V+ +Q+QL   PKPFP LKIN EK
Sbjct: 415 SITTYSLLTCIIAHVCDLVAGDFIYVIGQARINKARVKAIQKQLQISPKPFPILKINPEK 474

Query: 504 KDIDSFVAADFKLVG 518
           K +D+F A+D +L+G
Sbjct: 475 KKMDNFEASDLELLG 489


>G4YSZ0_PHYSP (tr|G4YSZ0) Putative uncharacterized protein OS=Phytophthora sojae
           (strain P6497) GN=PHYSODRAFT_555231 PE=3 SV=1
          Length = 491

 Score =  510 bits (1314), Expect = e-142,   Method: Compositional matrix adjust.
 Identities = 265/508 (52%), Positives = 328/508 (64%), Gaps = 38/508 (7%)

Query: 25  QRTYQVVVAATKDMG-IGKDGKLPWRLFTDLKFFKEITTA--TSDPGKKNAIVMGRKTWE 81
           +R+ +VVVAA +  G IG   ++PWRL +D+K FK +TTA  +S    ++A++MGRKTWE
Sbjct: 3   ERSVRVVVAALEATGGIGLRQQIPWRLPSDMKHFKALTTAPSSSSSSAQHAVIMGRKTWE 62

Query: 82  SIPLKYRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFV 139
           S+P K RP+P R NVVLTR  S+    G  E+V +  S                +++VFV
Sbjct: 63  SLPAKVRPMPQRYNVVLTRDASYRQSQGVPESVGVAASFREALELVQQQ--GDEVDQVFV 120

Query: 140 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVD-STKYQLWYSSFPKVENDIRYS 198
           IGGG ++ E L   GC  +H T +  + ECD F P       +++   S  K EN +++ 
Sbjct: 121 IGGGAVYAEALAYVGCSKVHLTRVKGAFECDAFFPLEQLEQNFEVTSESELKEENGVQFQ 180

Query: 199 FATYVRV--QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQ 256
           F    R   QS    +L+  T P                          HEE  YL LI+
Sbjct: 181 FVELERKTEQSVETTTLADATTP--------------------------HEEMQYLDLIR 214

Query: 257 EIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISGSTN 315
           +I+++            LS FG QMRF+LR + FPLLTTK+VFWRGV EELLWFISG T+
Sbjct: 215 KILTQGAKRGDRTGTGTLSVFGAQMRFSLRDNVFPLLTTKRVFWRGVAEELLWFISGDTS 274

Query: 316 AKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQG 375
           A  LQ+K IHIWDGN SREYLDS GL  RE GDLGPVYGFQWRHFGA+Y+DMH DY+ QG
Sbjct: 275 AHTLQQKDIHIWDGNGSREYLDSRGLQSREVGDLGPVYGFQWRHFGAKYTDMHADYTNQG 334

Query: 376 YDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSA 435
            DQL +VI+K++ NP DRRI+LSAWNP DL  MALPPCHMF QF+VA+GELSCQMYQRSA
Sbjct: 335 VDQLAEVIHKLRTNPTDRRIVLSAWNPADLNEMALPPCHMFCQFYVADGELSCQMYQRSA 394

Query: 436 DMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFP 495
           DMGLGVPFNIASYALLT ++A V  L PG+FVHVIGDAHVY NHV PLQ+QL  +P+PFP
Sbjct: 395 DMGLGVPFNIASYALLTRLVAQVTGLKPGEFVHVIGDAHVYLNHVEPLQKQLTRMPRPFP 454

Query: 496 TLKINSEK-KDIDSFVAADFKLVGYNPH 522
           TL IN  K   ID F   D ++  Y PH
Sbjct: 455 TLHINPGKTSSIDDFTFEDLEVRDYKPH 482


>H3GWN7_PHYRM (tr|H3GWN7) Uncharacterized protein OS=Phytophthora ramorum PE=3
           SV=1
          Length = 493

 Score =  509 bits (1312), Expect = e-142,   Method: Compositional matrix adjust.
 Identities = 263/509 (51%), Positives = 327/509 (64%), Gaps = 39/509 (7%)

Query: 25  QRTYQVVVAATKDMG-IGKDGKLPWRLFTDLKFFKEITTATSDPGK-KNAIVMGRKTWES 82
           +R+ +VVVAA +  G IG   ++PWRL +D+K F+ +TTA+  P   ++A++MGRKTWES
Sbjct: 4   ERSIRVVVAALESTGGIGLSQQIPWRLPSDMKRFRSLTTASPSPSSAQHAVIMGRKTWES 63

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDI--GTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVI 140
           +P K RP+P R NV+LTR  S+       E V +  S                +++VFVI
Sbjct: 64  LPAKVRPMPKRYNVILTRDTSYRQRQDVPEAVGVAASFHEALELVQQ--QEQEVDQVFVI 121

Query: 141 GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVD-STKYQLWYSSFPKVENDIRYSF 199
           GGG ++ E L   GC  +H T +    ECD F P    +  +Q+ + S    EN +++ F
Sbjct: 122 GGGAVYGEALAYSGCHKVHLTRVKGQFECDAFFPSAQLAQNFQVTHESELMEENGVQFQF 181

Query: 200 ATYVR----VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLI 255
             + R    V      +L   T P                          HEE  YL LI
Sbjct: 182 VEWERKTEAVNGVGKTALVDATRP--------------------------HEEMQYLDLI 215

Query: 256 QEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISGST 314
           ++I+++            LS FG QMRF+LR + FPLLTTK+VFWRGV EELLWFISG T
Sbjct: 216 RKILTQGAKRGDRTGTGTLSVFGAQMRFSLRENVFPLLTTKRVFWRGVAEELLWFISGDT 275

Query: 315 NAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQ 374
           +A  LQ+K IHIWDGN SREYLDS GL  RE GDLGPVYGFQWRHFGARY+DMH DY+GQ
Sbjct: 276 SAHTLQQKDIHIWDGNGSREYLDSRGLQSREVGDLGPVYGFQWRHFGARYTDMHADYTGQ 335

Query: 375 GYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRS 434
           G DQL +VI+K++ NP DRRI+LSAWNP DL  MALPPCHMF QF+VA+GELSCQMYQRS
Sbjct: 336 GVDQLAEVIHKLRTNPTDRRIVLSAWNPADLNEMALPPCHMFCQFYVADGELSCQMYQRS 395

Query: 435 ADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPF 494
           ADMGLGVPFNIASYALLT ++A V  L PG+F+HVIGDAHVY NHV PLQ+QL   P+PF
Sbjct: 396 ADMGLGVPFNIASYALLTRLVAQVAGLKPGEFIHVIGDAHVYLNHVEPLQKQLTRSPRPF 455

Query: 495 PTLKINSEK-KDIDSFVAADFKLVGYNPH 522
           PTL IN EK  +ID F   D ++  Y PH
Sbjct: 456 PTLHINPEKITNIDDFAFEDLEVRDYRPH 484


>D0N806_PHYIT (tr|D0N806) Bifunctional dihydrofolate reductase-thymidylate
           synthase 2 OS=Phytophthora infestans (strain T30-4)
           GN=PITG_06749 PE=3 SV=1
          Length = 509

 Score =  507 bits (1305), Expect = e-141,   Method: Compositional matrix adjust.
 Identities = 259/501 (51%), Positives = 323/501 (64%), Gaps = 34/501 (6%)

Query: 25  QRTYQVVVAATKDMG-IGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 83
           +++ +VVVAA +  G IG    +PWRL +D+K F+ +TTA+ D   ++A++MGRKTWES+
Sbjct: 3   EQSIRVVVAALETTGGIGLRQHIPWRLPSDMKHFRALTTASPDSSVQHAVIMGRKTWESL 62

Query: 84  PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
           P K RP+P R NVVLTR  S+         +  +                +++VFVIGGG
Sbjct: 63  PAKVRPMPKRYNVVLTRDSSYRNKQEIPDTVGVAASFREALKLVQEQGDKVDQVFVIGGG 122

Query: 144 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVD-STKYQLWYSSFPKVENDIRYSFATY 202
            ++ E L+ P C  +H T +    ECD F P       +++   S  K EN +++ F  +
Sbjct: 123 AVYAEALSYPSCTKVHLTRVKGQFECDAFFPLEQLEQNFKVAEESEVKEENGVQFHFVEW 182

Query: 203 VR----VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEI 258
            R    V++  +  L  NT P                          HEE  YL LI++I
Sbjct: 183 ERKTGEVKAVESALLVDNTTP--------------------------HEEMQYLDLIRKI 216

Query: 259 ISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           +++            LS FG QMRF+LR + FPLLTTK+VFWRGV EELLWFISG T+A 
Sbjct: 217 LTQGAKREDRTGTGTLSVFGAQMRFSLRNNVFPLLTTKRVFWRGVAEELLWFISGDTSAH 276

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            LQ+K IHIWDGN SREYLDS GL  RE GDLGPVYGFQWRHFGA+Y+DMH DY+G+G D
Sbjct: 277 TLQQKDIHIWDGNGSREYLDSRGLQHREVGDLGPVYGFQWRHFGAKYTDMHADYTGKGVD 336

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI+K++ NP DRRI+LSAWNP DL  MALPPCHMF QF+VANGELSCQMYQRSADM
Sbjct: 337 QLAEVIHKLRTNPTDRRIVLSAWNPSDLNEMALPPCHMFCQFYVANGELSCQMYQRSADM 396

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLT ++A V  L PG+F+HVIGDAHVY NHV PLQ+QL   P PFPTL
Sbjct: 397 GLGVPFNIASYALLTRLVAQVTGLKPGEFIHVIGDAHVYLNHVEPLQKQLTRTPCPFPTL 456

Query: 498 KINSEK-KDIDSFVAADFKLV 517
            IN EK   ID F   DF+ V
Sbjct: 457 HINPEKTSSIDEFTFEDFEWV 477


>M4BX13_HYAAE (tr|M4BX13) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Hyaloperonospora arabidopsidis (strain
           Emoy2) PE=3 SV=1
          Length = 494

 Score =  506 bits (1302), Expect = e-140,   Method: Compositional matrix adjust.
 Identities = 261/508 (51%), Positives = 332/508 (65%), Gaps = 37/508 (7%)

Query: 26  RTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKK-NAIVMGRKTWESI 83
           R   V+VAA + + GIG   K+PW L TD+K F+ +TT+  DP K+ +A++MGRKTWES+
Sbjct: 4   RALSVIVAALETNGGIGLQQKIPWHLPTDMKHFRALTTSRCDPLKQQHAVIMGRKTWESL 63

Query: 84  PLKYRPLPGRLNVVLTRSGSFDIGTAENV--VICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           P   RPLP R NV+LTR  S+   T EN+   +  +                +++VFVIG
Sbjct: 64  PTAVRPLPKRYNVILTRDLSYR--TRENIPDTVGVAASFSEALKLVELQGEKVDQVFVIG 121

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMP-PVDSTKYQLWYSSFPKVENDIRYSFA 200
           G  ++ E L    C+ +  T +    +CD F P  +   K+ +   S  K END+ + F 
Sbjct: 122 GSAVYAESLAHSECKKVFLTRVKGEFKCDAFFPLELLKQKFTVTNESEIKKENDVEFQFV 181

Query: 201 TYVRVQS----SAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQ 256
            + R  +    +A E+L+     + DN +                    HEE  YL LIQ
Sbjct: 182 EWARNDTEEVIAAVETLA-----MADNTTS-------------------HEEMQYLDLIQ 217

Query: 257 EIISEXXXXXXXXXXXXLSKFGCQMRFNLRR-SFPLLTTKKVFWRGVVEELLWFISGSTN 315
           +I+S+            LS FG QMRF+LR  +FPLLTTK+VFWRGV EELLWFI G T+
Sbjct: 218 KILSQGVQRTDRTGTGTLSVFGAQMRFSLRNNAFPLLTTKRVFWRGVAEELLWFIKGDTS 277

Query: 316 AKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQG 375
           A  LQ+KG+ IWDGN SREYLDS GL  RE GDLGPVYGFQWRHFGA+Y+DMH DY+GQG
Sbjct: 278 AHTLQQKGVRIWDGNGSREYLDSRGLQSREVGDLGPVYGFQWRHFGAKYTDMHADYTGQG 337

Query: 376 YDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSA 435
            DQL +VI+K++ NP+DRRI+LSAWNP DL  MALPPCHMF QF+VA+GELSCQMYQRSA
Sbjct: 338 VDQLAEVIHKLRTNPSDRRIVLSAWNPADLNDMALPPCHMFCQFYVADGELSCQMYQRSA 397

Query: 436 DMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFP 495
           DMGLGVPFNIASYALLT ++A V  L PG+F+HVIGDAHVY NHV PLQ+Q+L +P+PFP
Sbjct: 398 DMGLGVPFNIASYALLTRLVAQVAGLKPGEFIHVIGDAHVYLNHVEPLQKQILRVPRPFP 457

Query: 496 TLKINSEK-KDIDSFVAADFKLVGYNPH 522
           TL IN EK   ID F   D ++  Y+P+
Sbjct: 458 TLYINPEKTTSIDDFTYDDLEVRDYHPY 485


>B8BKI9_ORYSI (tr|B8BKI9) Putative uncharacterized protein OS=Oryza sativa subsp.
           indica GN=OsI_36122 PE=4 SV=1
          Length = 404

 Score =  504 bits (1298), Expect = e-140,   Method: Compositional matrix adjust.
 Identities = 234/344 (68%), Positives = 269/344 (78%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + RE LN P CEA+H T+I +SIECDTF+PP+D + +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    LSKFGCQMRFNLR SFPLLTTKKVFWRGVVEELLWFISGST+AKVLQEKGI
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFISGSTSAKVLQEKGI 314

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           HIWDGNASREYLDS+GL  REEGDLGPVYGFQWRHFGA     H
Sbjct: 315 HIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAESVAKH 358


>F0YJX9_AURAN (tr|F0YJX9) Putative uncharacterized protein OS=Aureococcus
           anophagefferens GN=AURANDRAFT_38942 PE=3 SV=1
          Length = 510

 Score =  501 bits (1291), Expect = e-139,   Method: Compositional matrix adjust.
 Identities = 263/512 (51%), Positives = 314/512 (61%), Gaps = 25/512 (4%)

Query: 20  PLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKT 79
           P  +L +   +V A     GIGKDG LPW+L  D+K+FK++T+A  + GK NA VMGRKT
Sbjct: 10  PTNDLPQLTCIVAAVAGSYGIGKDGTLPWKLAGDMKYFKKVTSAAPE-GKTNACVMGRKT 68

Query: 80  WESIPLKYRPLPGRLNVVLTRS--GSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKV 137
           W SIP K+RPL GR NVVL+R+     ++G   +V +C S+               + +V
Sbjct: 69  WLSIPPKFRPLGGRKNVVLSRNPNAREELGLPPDVFVCPSLDAAVDALAGE---ADLGEV 125

Query: 138 FVIGGGQIFREVLNAPGCEAIHFTEIH----ASIECDTFMPPVDSTKYQLWYSSFPKVEN 193
           FVIGGGQ++   L    C  +  T I     A  +CD   P      +    S    VEN
Sbjct: 126 FVIGGGQVYASALADARCTKVLLTSIDDAAGAFADCDAVFPDPAKAGFASAASGEALVEN 185

Query: 194 DIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLR 253
            + Y F T  R              PL ++N               +     HEE  YL 
Sbjct: 186 GVAYRFETLTR---------PAKKPPLRESNGPPAPPPANE-----KPAAPNHEEKQYLD 231

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISG 312
           LI EI+              +S FG +M F+LR   FPLLTTK+VFWRGV EEL+WF+SG
Sbjct: 232 LIAEILDRGVRRGDRTGTGTISIFGARMSFSLRNDRFPLLTTKRVFWRGVAEELVWFVSG 291

Query: 313 STNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYS 372
           STN K+L +KGIHIWDGN SRE+LD  GL  REE DLGPVYGFQWRHFGA+Y DMHKDY+
Sbjct: 292 STNGKLLADKGIHIWDGNGSREFLDRRGLGHREEMDLGPVYGFQWRHFGAKYVDMHKDYA 351

Query: 373 GQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQ 432
           G+G DQL   +  IK +PN RRI+LSAWNP DL  MALPPCHMF QF+VANGELSCQMYQ
Sbjct: 352 GEGVDQLAACVETIKQDPNSRRIVLSAWNPADLDEMALPPCHMFCQFYVANGELSCQMYQ 411

Query: 433 RSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPK 492
           RSADMGLGVPFNIASYALLT M+A    L PGDFVHVIGDAHVY NHV  L+ QL   P+
Sbjct: 412 RSADMGLGVPFNIASYALLTRMVAQATGLKPGDFVHVIGDAHVYSNHVDALKVQLQREPR 471

Query: 493 PFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PFPTL IN  K  ID F  ADF + GY P+ K
Sbjct: 472 PFPTLTINPAKTGIDDFEFADFTVEGYKPYPK 503


>R0FWL1_9BRAS (tr|R0FWL1) Uncharacterized protein OS=Capsella rubella
           GN=CARUB_v10023109mg PE=4 SV=1
          Length = 483

 Score =  499 bits (1286), Expect = e-139,   Method: Compositional matrix adjust.
 Identities = 261/495 (52%), Positives = 339/495 (68%), Gaps = 34/495 (6%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           +R+YQVV+AAT+DMG+G D KLPW L  + +FF+ +TT TSDP K+NA +MGRKTW+S P
Sbjct: 19  RRSYQVVIAATRDMGLGMDMKLPWDLPMEYEFFQGVTTKTSDPKKRNATIMGRKTWDSTP 78

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
           L++RPL GRLNVVLT S   DIG  +NV++C ++          PY LSIE VFVIGGG+
Sbjct: 79  LEFRPLLGRLNVVLTSSSCLDIGADDNVLVCSTMESALELLATAPYSLSIETVFVIGGGE 138

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + R  +NAP CEAIH TEI  S+ CD F P VD++ Y  WYSSFP++EN  RYSF TYVR
Sbjct: 139 LLRNYMNAPDCEAIHLTEIDISVPCDAFAPRVDTSLYHPWYSSFPRMENGTRYSFNTYVR 198

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
            ++    S  + +    D       F+ Q + FLP+M+ +RHEE+ YL L+Q IIS    
Sbjct: 199 RKNHIFGSGEKKSVVGSD-------FK-QYYSFLPKMVFERHEEFGYLNLVQNIIS---- 246

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG- 323
                    LSKFGCQMRFNLR++FPLLTTKKVFW GVVEE L  ISGSTN K   EKG 
Sbjct: 247 TGDMNDNTTLSKFGCQMRFNLRKTFPLLTTKKVFWLGVVEETLQLISGSTNPK---EKGN 303

Query: 324 IHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVI 383
            HIWD + ++EY++S      EE    P+   QWR+     SD  K+     ++QL DVI
Sbjct: 304 NHIWDSDEAKEYINSFRENATEEEVDNPL---QWRN-----SDSSKE-----FNQLSDVI 350

Query: 384 NKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPF 443
           NKIK+NP+ ++I+LS +N   LKL ++ PC   AQF+VANGELSCQ+YQ S +  L +PF
Sbjct: 351 NKIKNNPHKQKIMLSTYN---LKL-SVSPCQTVAQFYVANGELSCQIYQNSTEASLEIPF 406

Query: 444 NIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           +IA+Y+LLTC+IAHVC+LV GDF+HVIG A++   HV+ +Q+QL   P PFP LKIN +K
Sbjct: 407 SIAAYSLLTCIIAHVCDLVAGDFIHVIGQANINKTHVQNIQKQLQISPIPFPILKINPQK 466

Query: 504 KDI-DSFVAADFKLV 517
           K I D+F A+D +L+
Sbjct: 467 KKIDDNFEASDLELL 481


>F0W9B4_9STRA (tr|F0W9B4) Bifunctional dihydrofolate reductasethymidylate
           synthase 2 putative OS=Albugo laibachii Nc14
           GN=AlNc14C39G3381 PE=3 SV=1
          Length = 494

 Score =  495 bits (1274), Expect = e-137,   Method: Compositional matrix adjust.
 Identities = 261/512 (50%), Positives = 322/512 (62%), Gaps = 44/512 (8%)

Query: 26  RTYQVVVAATKDM-GIGKDGKLPWRLFTDLKFFKEITTAT------SDPGKKNAIVMGRK 78
           RT  +VVAAT+D  GIG    +PW+L  DLK F+++TT T      +    +NA++MGRK
Sbjct: 3   RTISIVVAATEDCWGIGWRQSIPWKLAKDLKHFRDLTTRTFSFNGCNSQNMRNAVIMGRK 62

Query: 79  TWESIPLKYRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEK 136
           TWES+P  Y+PLP R N +LTR+ ++  D     +V I  S+               I +
Sbjct: 63  TWESLPPSYQPLPNRYNHILTRTTNYRIDHSVPHDVGISSSLADALEEIERQE---DIGR 119

Query: 137 VFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPP-VDSTKYQLWYSSFPKVENDI 195
           VF+IGG +++   L    C+ I+ T + A+ +CDTF P  +    +QL   S    EN+I
Sbjct: 120 VFIIGGQKVYEAALECTSCDRIYLTTVKATYQCDTFFPSNLKDRGFQLVSESDEMEENEI 179

Query: 196 RYSFATYVR--VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLR 253
           R+ F    R  V  +    L  N  P                          HEEY YL 
Sbjct: 180 RFHFRELSRPIVTITKHSGLYTNEKP--------------------------HEEYQYLN 213

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISG 312
           LI+ I++              S FG QMRFNLR   FPLLTTKKVFWRGV EELLWFISG
Sbjct: 214 LIRNIVANGVEKQDRTGVGTKSIFGVQMRFNLRNDMFPLLTTKKVFWRGVAEELLWFISG 273

Query: 313 STNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYS 372
           +TNAK LQ++ + IWDGN S  YL SIGL  REEGDLGP+YGFQWRHFGA+Y+DMH DY+
Sbjct: 274 NTNAKTLQDRKVRIWDGNGSSAYLKSIGLHHREEGDLGPIYGFQWRHFGAKYTDMHADYT 333

Query: 373 GQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQ 432
           GQG+DQL DVI K+K +PN RRIILSAWNP DL  MALPPCH+  QF+VA G+LSCQMYQ
Sbjct: 334 GQGFDQLADVILKLKTDPNGRRIILSAWNPNDLNEMALPPCHLMCQFYVAKGQLSCQMYQ 393

Query: 433 RSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPK 492
           RSADMGLGVPFNIASYALLT MIAHV  L PG+FVHVIGDAH+Y NH+ PL+ QL   P+
Sbjct: 394 RSADMGLGVPFNIASYALLTKMIAHVTYLTPGEFVHVIGDAHIYLNHLEPLKLQLERTPR 453

Query: 493 PFPTLKI--NSEKKDIDSFVAADFKLVGYNPH 522
           PFPTL I   ++ + ID F   DF+L  Y P+
Sbjct: 454 PFPTLLIRPRNDLRTIDDFEFTDFELQNYEPY 485


>D8LWN8_BLAHO (tr|D8LWN8) Thymidylate synthase OS=Blastocystis hominis
           GN=GSBLH_T00000592001 PE=3 SV=1
          Length = 495

 Score =  491 bits (1265), Expect = e-136,   Method: Compositional matrix adjust.
 Identities = 244/501 (48%), Positives = 317/501 (63%), Gaps = 34/501 (6%)

Query: 28  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 87
           + +V A T   GIG +G LPWR+  D+KFF ++TT T+D  K+NA+++G+ T+ S P K+
Sbjct: 6   FSIVAAMTTKRGIGLNGGLPWRIKQDMKFFVDLTTTTTDSEKQNAVIIGKNTYFSFPEKF 65

Query: 88  RPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 145
           RPL  R+N +++            ++V IC S+               IE +FVIGGGQI
Sbjct: 66  RPLKNRINFIISHDKELREKHNIPDSVYICSSVDEALILMQEEELKRKIENIFVIGGGQI 125

Query: 146 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 205
           +++ +N P CE ++ TE+ A I CDTF P +    Y+    S    EN+ ++ FA Y R+
Sbjct: 126 YKKAINLPECEKLYLTEVDADISCDTFFPEI-PLAYKKTKESETFEENNFKFRFAEYTRL 184

Query: 206 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP--EMILQRHEEYMYLRLIQEIISEXX 263
             +                            FLP     LQ HEE  YL LI+ I+    
Sbjct: 185 PMT----------------------------FLPPYRTSLQEHEELQYLNLIRYILDHGA 216

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEK 322
                      S FG QMRF L     PLLTTKKVFWRG+VEELLWFI G T+ +VL+EK
Sbjct: 217 LRTDRTNTGTRSVFGTQMRFLLANGVIPLLTTKKVFWRGIVEELLWFIRGCTDGRVLKEK 276

Query: 323 GIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDV 382
            IHIWDGN +R +LDS+GLT+ EE DLGP+YGFQWRHFGA Y    KDYS QG DQL +V
Sbjct: 277 NIHIWDGNGTRSFLDSVGLTQNEEDDLGPIYGFQWRHFGAAYEGRDKDYSNQGVDQLKEV 336

Query: 383 INKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVP 442
           I+ +K +P +RRIILSAWNP DL+ MALPPCH+ +QF+V NG LSCQMYQRSADMGLGVP
Sbjct: 337 IHLLKTDPYNRRIILSAWNPADLRKMALPPCHVMSQFYVQNGYLSCQMYQRSADMGLGVP 396

Query: 443 FNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSE 502
           FNIASY+LLT ++AH+  L PG+FVH IGD HVY NH   L +Q+   P+PFPTL+I  +
Sbjct: 397 FNIASYSLLTILLAHITGLKPGEFVHSIGDTHVYVNHEEALLQQIEREPRPFPTLRITKQ 456

Query: 503 KKDIDSFVAADFKLVGYNPHQ 523
            ++I+ +  ADF+LVGYNPH+
Sbjct: 457 SENIEEYTFADFELVGYNPHE 477


>B7FQJ9_PHATC (tr|B7FQJ9) Predicted protein (Fragment) OS=Phaeodactylum
           tricornutum (strain CCAP 1055/1) GN=PHATRDRAFT_1690 PE=3
           SV=1
          Length = 495

 Score =  479 bits (1234), Expect = e-133,   Method: Compositional matrix adjust.
 Identities = 256/517 (49%), Positives = 311/517 (60%), Gaps = 53/517 (10%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 89
           VV AA    GIG  G LPWRL  DL+ F+ +TT   + G  NA++MGRKTW+SIP ++RP
Sbjct: 1   VVAAAASHRGIGYQGSLPWRLPGDLRHFQAVTTQPPETGGTNAVIMGRKTWDSIPDRFRP 60

Query: 90  LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 149
           LPGR+NVVLTR     +    + V+  +           P   ++  VFVIGGGQ++ + 
Sbjct: 61  LPGRINVVLTRHPERTL--WPDGVLTATSLADAAALLAQP-TRAVGHVFVIGGGQVYEQA 117

Query: 150 LNAPGCEAIHFTEIH---ASIECDTFMPPVDSTKYQL--WYSSFPKVEND---------- 194
           L       + +TE+    A  + D F PP+   ++Q   W +S      +          
Sbjct: 118 LREKFVNRVVYTEVANLPADSKFDAFFPPLPDAEWQAQPWQTSTTATNKENGNAPETGAW 177

Query: 195 -------IRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHE 247
                  I Y F  Y R  +S          P  D N+                     E
Sbjct: 178 HTDGPSGITYRFLEYTRKVASV------TVQPPTDGNA---------------------E 210

Query: 248 EYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR-SFPLLTTKKVFWRGVVEEL 306
           E  YL L + I+              LS+FG QMRF+LR  + PLLTTK+VFWRGV EEL
Sbjct: 211 ERQYLDLCRHILDHGVRRGDRTGTGTLSQFGTQMRFSLRDGTLPLLTTKRVFWRGVAEEL 270

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWF++G+TNA  L  K I IWDGN SR++LDS GL  RE GDLGPVYGFQWRHFGA Y  
Sbjct: 271 LWFVAGNTNANDLAAKDIRIWDGNGSRDFLDSRGLGHREVGDLGPVYGFQWRHFGATYGT 330

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DY+G+G DQL + I+KIK+NP DRRIILSAWNP DL+LMALPPCHMF QF+V    L
Sbjct: 331 MHDDYTGKGVDQLAECIDKIKNNPEDRRIILSAWNPADLELMALPPCHMFCQFYVRTASL 390

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQMYQRSADMGLGVPFNIASYALLT MIAHV    PGDFVH IGDAHVY NHV  LQ Q
Sbjct: 391 SCQMYQRSADMGLGVPFNIASYALLTHMIAHVTGRKPGDFVHTIGDAHVYLNHVDALQTQ 450

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
           L   P+ FP L+IN +K++ID FV ADF +VGY PH+
Sbjct: 451 LERTPRAFPKLQINPDKQNIDDFVFADFTVVGYQPHK 487


>K0T9B5_THAOC (tr|K0T9B5) Uncharacterized protein OS=Thalassiosira oceanica
           GN=THAOC_04721 PE=3 SV=1
          Length = 1016

 Score =  478 bits (1231), Expect = e-132,   Method: Compositional matrix adjust.
 Identities = 253/518 (48%), Positives = 315/518 (60%), Gaps = 46/518 (8%)

Query: 35  TKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRL 94
           +K  GIG  G+LPWRL  D+K FK++TT     G  NA++MGRKTWESIP K+RPL GR+
Sbjct: 85  SKSRGIGHKGELPWRLPGDMKHFKKVTTTPPSAGLTNAVIMGRKTWESIPSKFRPLDGRI 144

Query: 95  NVVLTRSGSF----DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVL 150
           NV+L+RSGS      +  +  V++  S+               +   FVIGGG+I+ + +
Sbjct: 145 NVILSRSGSAAPPERLSESSPVIVATSLEQAMARIEARS---DVGSTFVIGGGEIYNQAV 201

Query: 151 NAPGCEAIHFTEIHA---SIECDTFMPPVDSTKYQLWYSSFP-----------KVE---- 192
            +     + +T +       E D F P +   +++      P           KVE    
Sbjct: 202 ESGLVSRVVYTNVKGLPDDAEFDAFFPEMGEGEWECVPYCAPGEDGERAPKKAKVEEQTD 261

Query: 193 --NDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYM 250
             + +RY F  YVR  +  A ++S  ++                 D +PE      EE  
Sbjct: 262 AKSGLRYEFLEYVRRDADIAPAVSMESE--------------TTEDAIPEGPEVNPEEMQ 307

Query: 251 YLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR-SFPLLTTKKVFWRGVVEELLWF 309
           YL + ++II               SKFG QMR++LR  + PLLTTK+ FWRGV EELLWF
Sbjct: 308 YLDICRDIIENGVQRGDRTGTGTKSKFGVQMRYSLRDGALPLLTTKRTFWRGVAEELLWF 367

Query: 310 ISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHK 369
           +SGSTNA  L +K IHIWDGN SRE+LDS GL+ REEGDLGPVYGFQWRHFGA Y DM  
Sbjct: 368 VSGSTNANELADKNIHIWDGNGSREFLDSRGLSHREEGDLGPVYGFQWRHFGAEYEDMRA 427

Query: 370 DYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV--ANGELS 427
           DY G+G DQL D I+KI++NP DRRI++SAWNP DL  MALPPCHMF QF+V     ELS
Sbjct: 428 DYKGKGVDQLADCIDKIRNNPEDRRIVMSAWNPADLDKMALPPCHMFCQFYVDTEKNELS 487

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           CQMYQRSADMGLGVPFNIASYALLT M+A V    PGDFVH IGDAHVY NHV  L+EQL
Sbjct: 488 CQMYQRSADMGLGVPFNIASYALLTHMVAKVTGRKPGDFVHTIGDAHVYLNHVDALKEQL 547

Query: 488 LNLPKPFPTLKINSEKK--DIDSFVAADFKLVGYNPHQ 523
              P+ FP LK+   KK  DID FV  DF++ GY PH+
Sbjct: 548 ERKPRAFPRLKMKDGKKYDDIDGFVYEDFEVEGYKPHK 585


>R7Q5X1_CHOCR (tr|R7Q5X1) Bifunctional dihydrofolate reductase (DHFR) and
           thymidylate synthase (TS) OS=Chondrus crispus
           GN=CHC_T00010030001 PE=4 SV=1
          Length = 515

 Score =  474 bits (1219), Expect = e-131,   Method: Compositional matrix adjust.
 Identities = 248/503 (49%), Positives = 311/503 (61%), Gaps = 43/503 (8%)

Query: 27  TYQVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           T  ++ A +   GIG  G LPW RL +DL+ FK +T          A++MG  T+ES+P 
Sbjct: 44  TSLILAACSPSRGIGLAGALPWPRLPSDLRNFKTLTLGA-------AVLMGAATYESLPE 96

Query: 86  KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 145
             RPLPGRLNVVL+R    ++   ++V+I GS                +E  FVIGG  +
Sbjct: 97  AVRPLPGRLNVVLSRRSRPELLVPDDVLIAGSFDAAEELLKSK----GVENCFVIGGESV 152

Query: 146 FREVLNAPG-CEAIHFTEIHASIECDTFMPPVDSTK---YQLWYSSFPKVENDIRYSFAT 201
           +RE +  P   + +++TEI    + D F P VD  K   + L   S    E+ +RY    
Sbjct: 153 YREAIKIPAWSQRVYYTEIDKEFKADRFFP-VDLAKEPAFSLLSVSGDIEESGVRYRIKE 211

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           YVRV                D+   S             ++   HEE  YL L++ I+  
Sbjct: 212 YVRVSP--------------DDEPSSRA-----------VVCPPHEEEQYLDLVRHILER 246

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       +S FG QMRF+LR SFPLLTTK+VFWR V EEL WFI GST++  L +
Sbjct: 247 GVSKGDRTGVGTISVFGAQMRFDLRHSFPLLTTKRVFWRAVAEELFWFIQGSTDSNKLAK 306

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           KG+HIWDGN SRE+LD+ G  ERE GDLGPVYGFQWRHFGA Y+DMH DY+G+G DQL +
Sbjct: 307 KGVHIWDGNGSREFLDTRGFPEREVGDLGPVYGFQWRHFGAEYTDMHADYAGKGRDQLKE 366

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VI+ +K+NPNDRRI+LSAWNPV    MALPPCH+ AQF+VANGELSCQMYQRS DMGLGV
Sbjct: 367 VIDTVKNNPNDRRILLSAWNPVATDQMALPPCHLLAQFYVANGELSCQMYQRSCDMGLGV 426

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASYALLTC+IA V  L PGDFVH +GDAHVY+NHV  L+EQ+   P+PFP L I  
Sbjct: 427 PFNIASYALLTCLIAKVTGLRPGDFVHTLGDAHVYNNHVEALREQVQRKPRPFPQLSIR- 485

Query: 502 EKKDIDSFVAADFKLVGYNPHQK 524
           E+ +I+ F   D  L GY PH+K
Sbjct: 486 ERGEIEDFSFEDLTLEGYRPHKK 508


>Q22KR8_TETTS (tr|Q22KR8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Tetrahymena thermophila (strain SB210)
           GN=TTHERM_00312120 PE=3 SV=1
          Length = 485

 Score =  471 bits (1213), Expect = e-130,   Method: Compositional matrix adjust.
 Identities = 239/502 (47%), Positives = 312/502 (62%), Gaps = 30/502 (5%)

Query: 26  RTYQVVVAAT-KDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           R + +V+A T K  GIG    LPWRL  +LK FK+ITT T + G +NA++MG+ TWE++P
Sbjct: 4   RHFDIVLAQTLKKQGIGYKNSLPWRLPNELKNFKKITTETKNKGLQNAVIMGKNTWEALP 63

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 144
            K +PL  RLN+V++ +   +   A++   C S+               I+   VIGG +
Sbjct: 64  KKQQPLKDRLNIVISTTMQ-EGQIADHSYACKSLDSALNFLEQQN---QIQDALVIGGAK 119

Query: 145 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 204
           + ++ L+      IH T +   +ECD FM       + +   S  + EN++ Y F  Y  
Sbjct: 120 LCQQALSDQRLRQIHLTRVGVEVECDVFMQKDYLKNFDMIEVSETQSENNLNYDFTRYFN 179

Query: 205 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 264
                 ++     DP                  L + + + H+EY YL LI EII     
Sbjct: 180 ------KNYKGQVDP-----------------SLFKKMYKPHQEYQYLELIDEIIKNGHV 216

Query: 265 XXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI 324
                    +S+FG  MRF+L +SFPLLTTK VFWRGVVEEL+WFI GSTN+K+L EKG+
Sbjct: 217 KTDRTGTGTISQFGKLMRFDLSKSFPLLTTKNVFWRGVVEELIWFIKGSTNSKILSEKGV 276

Query: 325 HIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVIN 384
            IWDGN SRE+LD +G   REEGDLGPVYGFQWRHFGA Y DMH +Y G+G DQL D+IN
Sbjct: 277 KIWDGNGSREFLDQLGFKNREEGDLGPVYGFQWRHFGAEYKDMHTNYKGKGVDQLQDLIN 336

Query: 385 KIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFN 444
            IK NP+ RR+I++AWN  DL LMALPPCH+ +QF+V + +LSC MYQRS DMGLG+PFN
Sbjct: 337 TIKKNPDSRRMIMNAWNVKDLPLMALPPCHVMSQFYVNDNKLSCMMYQRSCDMGLGIPFN 396

Query: 445 IASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           IASYALLT MIA V  +  G+F+HV+GDAHVY NHV  L+ QL   P PFP LKIN+ K+
Sbjct: 397 IASYALLTHMIAQVTNMQVGEFIHVLGDAHVYSNHVDQLKIQLERAPYPFPLLKINNNKQ 456

Query: 505 --DIDSFVAADFKLVGYNPHQK 524
              I+ F   DF+L+GYN H K
Sbjct: 457 YNSIEDFTLEDFELIGYNYHPK 478


>C5LQI2_PERM5 (tr|C5LQI2) Dihydrofolate reductase-thymidylate synthase, putative
           OS=Perkinsus marinus (strain ATCC 50983 / TXsc)
           GN=Pmar_PMAR025126 PE=3 SV=1
          Length = 492

 Score =  469 bits (1206), Expect = e-129,   Method: Compositional matrix adjust.
 Identities = 256/510 (50%), Positives = 313/510 (61%), Gaps = 33/510 (6%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTAT-SDPGKKNAIVMGRK 78
           LP L     V+VA T   GIGKDG+LPW+ L  D+K FK+ITT    +   KN  +MGRK
Sbjct: 3   LPQLS----VIVAHTCKWGIGKDGQLPWKSLPEDMKRFKKITTGGHCNDNVKNVCIMGRK 58

Query: 79  TWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVF 138
           TWESIP ++RPL  R+NVV++ + S        V IC S+             + I ++F
Sbjct: 59  TWESIPERFRPLRDRINVVISSTTS-PTDYPPGVRICPSLLDSLASLQQGE--VEIGEIF 115

Query: 139 VIGGGQIFREVLNAPGCEAIHFTEIHAS-IECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
           VIGG  +  E +  P C  ++ T +     ECD FM  +D   ++    S     +DI Y
Sbjct: 116 VIGGASLITEAMQLPQCRTLYTTRVGTDPWECDVFMEKIDEKIWEPIAVSRTFRHSDIPY 175

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
            F  Y R + S    LS              KF+              H EY YLRLI+E
Sbjct: 176 DFVDYKRREGSDKTELS------LAERCPRGKFQ--------------HGEYEYLRLIEE 215

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISGSTNA 316
           II               + F C MRF+LR   FPLLTTK+VFWRGVVEELLWFI G TNA
Sbjct: 216 IIENGEDADDRTGVGTKTIFSCHMRFSLRDGVFPLLTTKRVFWRGVVEELLWFIRGDTNA 275

Query: 317 KVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQ-G 375
           K L ++G+ IWD N +RE+LD  GLT REEGDLGPVYGFQWRHFGA Y DMH DYS   G
Sbjct: 276 KHLSDQGVKIWDLNGTREFLDGRGLTHREEGDLGPVYGFQWRHFGADYVDMHADYSKSGG 335

Query: 376 YDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV-ANGELSCQMYQRS 434
            DQL +VI ++K NP DRRII++AWNP  L LMALPPCHM  QF+V +  ELSC MYQRS
Sbjct: 336 VDQLAEVIRQLKENPMDRRIIMTAWNPTALPLMALPPCHMMCQFYVNSKQELSCAMYQRS 395

Query: 435 ADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPF 494
           ADMGLGVPFNIASYALLTCM+A VC L PG+F H +G+ HVY+NH+ PL++QL   P+PF
Sbjct: 396 ADMGLGVPFNIASYALLTCMLAQVCGLKPGEFCHHLGNTHVYNNHIEPLRQQLKRTPRPF 455

Query: 495 PTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           P LKIN   K ID   ++DF+L+GYNP  K
Sbjct: 456 PLLKINPNVKTIDDIKSSDFELIGYNPWGK 485


>M4C8Q3_BRARP (tr|M4C8Q3) Uncharacterized protein OS=Brassica rapa subsp.
           pekinensis GN=Bra000581 PE=4 SV=1
          Length = 452

 Score =  468 bits (1203), Expect = e-129,   Method: Compositional matrix adjust.
 Identities = 247/496 (49%), Positives = 319/496 (64%), Gaps = 56/496 (11%)

Query: 25  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 84
           +R+YQVV+AAT+DMGIG D KLPW L  + +FF+++T+ TSDP K+NA +MGRK+WE+ P
Sbjct: 8   RRSYQVVIAATRDMGIGIDMKLPWDLPNEFQFFQDVTSRTSDPRKRNATIMGRKSWEATP 67

Query: 85  LKYRPLPGRLNVVLTRSGSFDIGTAE-NVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
           L++RPLP RLNVVLTRS    I T + NV++CGS+          PY  SIEKVF IGGG
Sbjct: 68  LEFRPLPDRLNVVLTRSNCHSIPTDDDNVMVCGSMESALELLAKPPYSFSIEKVFFIGGG 127

Query: 144 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 203
           ++ R  +NAP C+AIH TE+  ++ CDTF P VD+  Y  WYSS P VEN IRY F TYV
Sbjct: 128 ELLRHYMNAPSCDAIHLTEVDITVPCDTFAPRVDTCLYHPWYSSLPVVENGIRYCFNTYV 187

Query: 204 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXX 263
           R +           D +F +       E + + FLP+M+ +RHEE+ YL L+Q IIS   
Sbjct: 188 RRK-----------DLIFGSG-----VEAEQYSFLPKMVFERHEEFGYLNLVQNIISNGD 231

Query: 264 XXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKG 323
                     LSKFGCQ               KVFW GVVEE+L  ISGST  K   EKG
Sbjct: 232 MNDNNTL---LSKFGCQ---------------KVFWVGVVEEILQLISGSTYPK---EKG 270

Query: 324 I-HIWDGNASREYLDSIGLTEREE-GDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           I HIW+ + ++EYLDS G+   EE GD   + G  W      YSD     + Q ++Q+ D
Sbjct: 271 INHIWESDKAKEYLDSFGVNATEEDGDHPLLTGLYWS-----YSD-----ASQEFNQISD 320

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VINKIK+NP+DR I LSA        +++ PC  FAQF+VANGELSCQ+YQ S +  LG+
Sbjct: 321 VINKIKNNPHDRGITLSACK------LSISPCQTFAQFYVANGELSCQIYQSSTEASLGI 374

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PF+IA+Y+LLTC++AHVC++V GDF+H+IGDAHV  +H + +Q QL   PKPFP LKIN 
Sbjct: 375 PFSIAAYSLLTCIMAHVCDVVAGDFIHLIGDAHVNTSHTKAIQRQLQISPKPFPILKINP 434

Query: 502 EKKDIDSFVAADFKLV 517
            KK ID   A+D  L+
Sbjct: 435 AKKKIDHLEASDLDLL 450


>B5YMV7_THAPS (tr|B5YMV7) Possible thymidylate synthase (Fragment)
           OS=Thalassiosira pseudonana GN=TMS1 PE=3 SV=1
          Length = 516

 Score =  468 bits (1203), Expect = e-129,   Method: Compositional matrix adjust.
 Identities = 252/521 (48%), Positives = 316/521 (60%), Gaps = 40/521 (7%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 89
           VV AA    GIG  GKLPWRL  D+  FK++TT    PG  NA++MGRKTW+SIP K+RP
Sbjct: 1   VVAAAAGSRGIGHQGKLPWRLPGDMNHFKKVTTTPPSPGLTNAVIMGRKTWDSIPSKFRP 60

Query: 90  LPGRLNVVLTRSGSFDI-------------GTAENVVICGSIXXXXXXXXXXPYCLSIEK 136
           L GR+NV+L+R  +  +               AE+V++  S+              S   
Sbjct: 61  LDGRVNVILSRKSAAGVEGVPMSTDDNNNNNNAEDVLVASSLEEAMQKLDGRANHGS--- 117

Query: 137 VFVIGGGQIFREVLNAPGCEAIHFTEIHASIE---CDTFMPPVDSTKYQLWYSSFPKVEN 193
            F+IGGG+I+ + + +   + + +T +    E    D F P +  ++++      PK   
Sbjct: 118 TFIIGGGEIYSQGIKSGLVKRVIYTNVKGLAEDAKLDAFFPELTDSEWEC-VPFTPKDNA 176

Query: 194 DIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEV------QNFDFLPEMILQRHE 247
           +   +   +V  ++  AE          ++    LK+E        N D +PE      E
Sbjct: 177 ENEETENNHVSKKAKVAEE--------HEDAKSGLKYEFLEYIRRDNVD-IPEGADVNPE 227

Query: 248 EYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVFWRGVVEEL 306
           E  YL + ++II              LSKFG QMR++LR  + PLLTTK+ FWRGV EEL
Sbjct: 228 EMQYLEICRDIIENGVRRGDRTGTGTLSKFGVQMRYSLRDNTLPLLTTKRTFWRGVAEEL 287

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWF+ GSTNA  L +K IHIWDGN SRE+LDS GL  REEGDLGPVYGFQWRHFGA Y D
Sbjct: 288 LWFVKGSTNANELADKNIHIWDGNGSREFLDSRGLQHREEGDLGPVYGFQWRHFGAEYKD 347

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN--G 424
           MH DY+GQG DQL D I+KI +NP DRRI++SAWNP DL +MALPPCHMF QF+V     
Sbjct: 348 MHADYTGQGVDQLADCIDKIINNPEDRRIVMSAWNPKDLDVMALPPCHMFCQFYVDTDRN 407

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           E+SCQMYQRSADMGLGVPFNIASYALLT MIA V     GDFVH IGDAHVY NHV  L+
Sbjct: 408 EVSCQMYQRSADMGLGVPFNIASYALLTHMIAKVTGRKAGDFVHTIGDAHVYLNHVDALK 467

Query: 485 EQLLNLPKPFPTLKINSEK--KDIDSFVAADFKLVGYNPHQ 523
           EQL   P+ FP LK+   K   DID F   DF++VGY PH+
Sbjct: 468 EQLERKPRAFPKLKMKDGKDFNDIDGFEFDDFEVVGYKPHK 508


>J9FQF0_9SPIT (tr|J9FQF0) Bifunctional dihydrofolate reductase-thymidylate
           synthase 2 / DHFR-TS (ISS) OS=Oxytricha trifallax
           GN=OXYTRI_22304 PE=3 SV=1
          Length = 526

 Score =  456 bits (1174), Expect = e-126,   Method: Compositional matrix adjust.
 Identities = 245/541 (45%), Positives = 320/541 (59%), Gaps = 73/541 (13%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDP----------------- 67
           + + V+VA +K+ GIG  G LPW ++  ++K F  +TT + DP                 
Sbjct: 10  KPFSVIVACSKNDGIGFKGDLPWPKIPKEMKHFVNVTT-SKDPLAFSPAENAFKNVFYQS 68

Query: 68  -----------GKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAEN--VVI 114
                       K NA++MGRKTW+SIPLK+RPL  R+NV+LT   + +    EN  + +
Sbjct: 69  GFTAKNPSNGLDKVNAVIMGRKTWDSIPLKFRPLTKRMNVILTNQQNLEDTNDENGLIQV 128

Query: 115 CGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLN--APGCEAIHFTEIHASIECDTF 172
                         P    + ++FVIGG  ++   +N  +  C+ I  T I+   E DTF
Sbjct: 129 YNDFERALESLSNDP---RVNEIFVIGGATVYDLAINKFSDFCKLIIKTRINKEFEVDTF 185

Query: 173 MPPVDST-KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFE 231
           MP +D    Y   Y S      D+ + +                     F  N   L ++
Sbjct: 186 MPKMDEEGAYSKLYISQTYSHQDVTFDYC--------------------FLGNKKLLSYK 225

Query: 232 VQNFDFLPEMILQR-------HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFN 284
                  PE+I  R       H E  YL +I++II              + KFG QMR++
Sbjct: 226 -------PELIPTRLFSKYPKHPEMQYLEIIKDIIETGSEKSDRTGVGIIGKFGYQMRYD 278

Query: 285 LRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTER 344
           L  SFP+LTTK VFWRGV EEL+WF+ G TNAK L +K I IWDGNASR++LDSIGL +R
Sbjct: 279 LEESFPILTTKDVFWRGVAEELVWFVKGDTNAKNLADKKIRIWDGNASRQFLDSIGLKDR 338

Query: 345 EEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVD 404
           EE DLGPVYGFQWRHFGA Y  MH DY+G+G+DQL DVIN++K+NP  RRI++SAWN  D
Sbjct: 339 EEWDLGPVYGFQWRHFGAAYETMHDDYTGKGFDQLADVINQLKNNPTSRRIVMSAWNAAD 398

Query: 405 LKLMALPPCHMFAQFFV-ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           LK MALPPCH+ AQF+V A+G+LSCQMYQRS DMGLG+PFNIASY+LLTCM+A VC L  
Sbjct: 399 LKNMALPPCHILAQFYVSADGKLSCQMYQRSCDMGLGIPFNIASYSLLTCMLAQVCGLKR 458

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
           G+F+HV+GDAHVY NHV PLQEQL   P PFP L +N +  +I+ F  +DFKL+ Y  H 
Sbjct: 459 GEFIHVLGDAHVYKNHVEPLQEQLKRYPYPFPQLVLNPDITNIEDFQFSDFKLINYTHHP 518

Query: 524 K 524
           +
Sbjct: 519 R 519


>M2Y9L6_GALSU (tr|M2Y9L6) Thymidylate synthase/dihydrofolate reductase
           OS=Galdieria sulphuraria GN=Gasu_03410 PE=3 SV=1
          Length = 503

 Score =  451 bits (1161), Expect = e-124,   Method: Compositional matrix adjust.
 Identities = 241/517 (46%), Positives = 312/517 (60%), Gaps = 58/517 (11%)

Query: 29  QVVVAATKDM-GIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 87
           ++VVA T++  GIG  GK+PW+L  DL+FFKE+T         N ++MGRKTWES+P   
Sbjct: 13  RIVVALTRNARGIGLLGKMPWKLKKDLQFFKELTLG-------NPVIMGRKTWESLPTAS 65

Query: 88  RPLPGRLNVVLTRSGSF------------DIGTAENVVI-CGSIXXXXXXXXXXPYCLSI 134
           +PL  RLNVVLT + +             D    E + + C S+           + ++ 
Sbjct: 66  KPLKKRLNVVLTSNPTLFQKNYLETLTDEDRTEEEGLCLACNSLESALNMLRLRSFPVA- 124

Query: 135 EKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND 194
              ++IGG Q+F E L  P C  ++ T I+    CDTF P + +  +QL  +S    EN 
Sbjct: 125 ---YIIGGRQVFEEALVNPACSRVYLTRIYEDFACDTFFPCLPNY-FQLVSNSEIFEENG 180

Query: 195 IRYSFATYVR-------VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHE 247
           I++ F  Y R       +  ++A    QN +P                        + HE
Sbjct: 181 IKFEFLEYRRDMYLTTGMNENSAHGKRQNINPS-----------------------RPHE 217

Query: 248 EYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELL 307
           EY YL L+++I+ +            LS FG QMRF+L+  FPLLTTKKVFWRGVV ELL
Sbjct: 218 EYQYLELVRKIVEQGVFKNDRTGVGTLSLFGHQMRFSLQGQFPLLTTKKVFWRGVVHELL 277

Query: 308 WFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDM 367
           WFISGSTNAK L EKGIHIWD NASR +LD+ G   REEGDLGPVYGFQWRHFGA+Y  M
Sbjct: 278 WFISGSTNAKKLSEKGIHIWDENASRAFLDNHGFLNREEGDLGPVYGFQWRHFGAKYRSM 337

Query: 368 HKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELS 427
           +  Y  +G DQL D+I  +K NPNDRR+IL+AWNP  +  MALPPCH+ AQF+V+N  LS
Sbjct: 338 NDCYDNEGVDQLTDIIETLKRNPNDRRMILTAWNPSAIPEMALPPCHILAQFYVSNDNLS 397

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           C MYQRS DMGLGVPFNI SYALLT MIA +  L PG+ ++ +GD H+Y NH+ PL  QL
Sbjct: 398 CHMYQRSCDMGLGVPFNIGSYALLTYMIAKLVHLSPGELIYSMGDVHIYQNHLGPLTFQL 457

Query: 488 LNLPKPFPTLKINS--EKKDIDSFVAADFKLVGYNPH 522
              P+PFP L I    + + ID FV +DF+L+ Y+PH
Sbjct: 458 NRKPRPFPRLIIKDRPDLQKIDDFVFSDFELIDYHPH 494


>G0TZ26_TRYVY (tr|G0TZ26) Putative dihydrofolate reductase-thymidylate synthase
           OS=Trypanosoma vivax (strain Y486) GN=TVY486_0705520
           PE=3 SV=1
          Length = 527

 Score =  446 bits (1148), Expect = e-123,   Method: Compositional matrix adjust.
 Identities = 236/524 (45%), Positives = 307/524 (58%), Gaps = 59/524 (11%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + V+VA  ++ GIG    +PW L  D++FFK+ TT      AT  P K+NA+VMGRKT
Sbjct: 27  RAFSVIVATDENGGIGDGTSIPWNLPEDMQFFKKTTTRLRGKNATPSPQKRNAVVMGRKT 86

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSFDI-------------GTAENVVICGSIXXXXXXXX 126
           WES+P K+RPL  RLNVVL+R+ + +                ++ +V+ G +        
Sbjct: 87  WESLPAKFRPLSNRLNVVLSRAATKEQLLAGIPSPSKRQEAESDVLVVNGGLSDALKLLV 146

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIE-CDTFMPPVDSTKYQ 182
             PY  S+E V+ IGGG I+ E +  P     +AI+ T +    E C+ F          
Sbjct: 147 QPPYTSSVETVYCIGGGSIYAEAIQQPCVDVLQAIYRTLVRTRAESCNVF---------- 196

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAES---LSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                           F    +  S+AAE        T+ L    S   K++ +      
Sbjct: 197 ----------------FHLPSKGTSNAAEREWVRESITEELTSTGSSGTKYQFE------ 234

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
           ++I +  EE  YL L+  II E            LS FG QMRF+LR    PLLTTK+VF
Sbjct: 235 KLIPRNTEEEQYLNLVSRIIKEGNVKEDRTGVGTLSLFGAQMRFSLRGNRLPLLTTKRVF 294

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNAK+L +KGIHIWDGN SR +LDS GLTE EE DLGPVYGFQWR
Sbjct: 295 WRGVCEELLWFLRGDTNAKLLSDKGIHIWDGNGSRAFLDSRGLTEYEEMDLGPVYGFQWR 354

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y+    +Y GQG DQ+  ++  +K NPNDRR+I +AWNPV L  MALPPCHM AQ
Sbjct: 355 HFGASYTRHDANYDGQGVDQIESIVKTLKENPNDRRMICTAWNPVALPRMALPPCHMMAQ 414

Query: 419 FFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHN 478
           F+V  GELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY N
Sbjct: 415 FYVNEGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKAAGLSPGELVHTLGDAHVYKN 474

Query: 479 HVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           HV P Q QL  +P+PFP +    +++ ++ +   D +++ Y P+
Sbjct: 475 HVEPCQLQLKRIPRPFPFIVFKRDRQFLEDYEEGDIEVIDYAPY 518


>R1BUZ9_EMIHU (tr|R1BUZ9) Uncharacterized protein OS=Emiliania huxleyi CCMP1516
           GN=EMIHUDRAFT_451981 PE=4 SV=1
          Length = 495

 Score =  446 bits (1147), Expect = e-122,   Method: Compositional matrix adjust.
 Identities = 245/545 (44%), Positives = 307/545 (56%), Gaps = 102/545 (18%)

Query: 20  PLPNLQRTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRK 78
           P     R + VVVAA K   GIG   +LPWRL  D+++FK++T +T DP K+NA++MGRK
Sbjct: 6   PAKEGGRRFSVVVAACKQSRGIGVSNQLPWRLRGDMQYFKQLTRSTRDPTKQNAVIMGRK 65

Query: 79  TWESIPLKYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEK 136
           TWESIP K RPL  RLNVV++ + +     G  + V++  S+           Y  S+E 
Sbjct: 66  TWESIPEKMRPLGDRLNVVISANPAARELYGMGDKVLLATSLGDALQQLCEGDYAASVES 125

Query: 137 VFVIGGGQIFREVLNAPG-CEAIHFTEI--HASIE------------------------- 168
           VFVIGG  ++ E ++ P  CE +++TE+  HA +                          
Sbjct: 126 VFVIGGSSVYAEAVDLPQLCERVYYTEVSKHAPLRDANGAAPPAAAAAVGPATEAAAAGC 185

Query: 169 ---------CDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDP 219
                    CDT  PP+ +  ++   +S P+ EN + Y F  +   +S  A +       
Sbjct: 186 VGGSDDPFGCDTHFPPLPADTWRQASASAPRDENGLSYRFLAFESRESPPAAA------- 238

Query: 220 LFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGC 279
                                     HEE  YL L++E+I                KFG 
Sbjct: 239 -------------------------PHEELQYLDLVREVIESGVSRPDRTGIGTRGKFGA 273

Query: 280 QMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSI 339
           QMRF+LR  FPLLTTK VFWRG                        IWDGN+SR+YLDSI
Sbjct: 274 QMRFSLRDRFPLLTTKTVFWRG------------------------IWDGNSSRDYLDSI 309

Query: 340 GLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSA 399
           GLTERE GDLGPVYG+QWRHFGA Y+DMH DY+G+G      V+  +K  P DRRII+SA
Sbjct: 310 GLTEREVGDLGPVYGWQWRHFGAEYTDMHADYTGKG------VVRALKEKPYDRRIIMSA 363

Query: 400 WNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC 459
           WNP DL  MALPPCHMFAQF+VANGELSCQMYQRSAD+GLGVPFNIASYALLTC++AHV 
Sbjct: 364 WNPKDLPKMALPPCHMFAQFYVANGELSCQMYQRSADLGLGVPFNIASYALLTCLLAHVT 423

Query: 460 ELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGY 519
            L  GDFVHVIGDAHVY+NHV  L+EQL   P  FP L+I+     I+    AD +LVGY
Sbjct: 424 GLKRGDFVHVIGDAHVYNNHVTALREQLTREPLLFPQLRISDAVTSIEECTFADLELVGY 483

Query: 520 NPHQK 524
             H K
Sbjct: 484 KSHGK 488


>M1VHU6_CYAME (tr|M1VHU6) Fusion protein of dihydrofolate reductase and
           thymidylate synthase OS=Cyanidioschyzon merolae strain
           10D GN=CYME_CMS462C PE=3 SV=1
          Length = 535

 Score =  444 bits (1141), Expect = e-122,   Method: Compositional matrix adjust.
 Identities = 236/532 (44%), Positives = 308/532 (57%), Gaps = 39/532 (7%)

Query: 21  LPNLQRTYQVVVAA-TKDMGIGKDGKLPW-RLFTDLKFFKEITT--------ATSDPGKK 70
           +PN+Q   ++VVA    D GIG +G+LPW  +  DL  FK +TT         ++  G K
Sbjct: 6   IPNVQLPLRIVVAVQAADWGIGYNGQLPWPHIAEDLAHFKRVTTRNCRSSEDESAVVGGK 65

Query: 71  NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPY 130
            A++MGR TW SIP + RPL GRLN+VLTR     +  A +      +            
Sbjct: 66  PAVIMGRHTWLSIPPERRPLSGRLNIVLTRQKPI-VNEASDAFAGAYLANSLNEACSLAA 124

Query: 131 CLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKY--- 181
                  +VIGG  +FRE L  P C+ I+ T I       A   CD FMP + S +Y   
Sbjct: 125 LHGARVAYVIGGASVFRETLAHPACDRIYLTRIRRLDPQRAPYPCDVFMPAIPSDEYVED 184

Query: 182 -----QLWYSSFPKVENDIRYSFATYVRVQ----SSAAESLSQNTDPLFDNNSDSLKFEV 232
                        +    +   F  Y R +    S + E     +D    +N+ +++  V
Sbjct: 185 GPSNKHCVSVCVDERAEQLEVEFLVYRRQERIPMSHSPERERVASDAKPSSNTKTIERPV 244

Query: 233 QNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPL 291
              +         HEE  YL L++ +I              LS FG  MRF+LR +  PL
Sbjct: 245 LECN---------HEEQQYLDLVRSVIGHGYRKADRTGVGTLSLFGAMMRFSLRNQCIPL 295

Query: 292 LTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGP 351
           LTTK+VFWRGVVEELLWF+ GST+A  L  +G+HIWDGNASR +LD+ GL+ R EGDLGP
Sbjct: 296 LTTKRVFWRGVVEELLWFLRGSTDATELSARGVHIWDGNASRAFLDARGLSHRAEGDLGP 355

Query: 352 VYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALP 411
           VYGFQWRHFGA+Y D   DY  QG DQ+  ++  +K NP+DRR++L AWNP+ L  MALP
Sbjct: 356 VYGFQWRHFGAKYVDCKTDYRNQGVDQIRQIVETLKTNPDDRRMLLCAWNPLALPEMALP 415

Query: 412 PCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIG 471
           PCH+ AQF+VANGELSC +YQRS D+GLGVPFNIASY+LLT M+AHV +L PG+ VH +G
Sbjct: 416 PCHVLAQFYVANGELSCLLYQRSCDLGLGVPFNIASYSLLTMMLAHVTDLRPGELVHTMG 475

Query: 472 DAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
           D HVY NHV  L+ QL   P+PFP ++     +DID F   D +L+GY PHQ
Sbjct: 476 DVHVYLNHVDALKVQLGRQPRPFPHIRFRRPVRDIDDFCTDDIELIGYYPHQ 527


>M0YHZ1_HORVD (tr|M0YHZ1) Thymidylate synthase OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 245

 Score =  442 bits (1136), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 204/244 (83%), Positives = 223/244 (91%)

Query: 281 MRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIG 340
           MRFNLR++FPLLTTK+VFWRGV+EELLWFISGSTNAKVLQEK I IWDGNASREYLDSIG
Sbjct: 1   MRFNLRKNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKNIRIWDGNASREYLDSIG 60

Query: 341 LTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAW 400
           L++REEGDLGPVYGFQWRHFGA YSDMH DY+G+G+DQL DVINKIK+NP+DRRIILSAW
Sbjct: 61  LSQREEGDLGPVYGFQWRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAW 120

Query: 401 NPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCE 460
           NP DLK MALPPCHMFAQF+V NGELSCQMYQRSADMGLGVPFNIASY+LLTCMIA VC+
Sbjct: 121 NPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCD 180

Query: 461 LVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYN 520
           L PG+FVHVIGDAHVY  HV+ L+EQL   PKPFP LKIN  KKDIDSFVA+DFKL  Y+
Sbjct: 181 LSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYD 240

Query: 521 PHQK 524
           PHQK
Sbjct: 241 PHQK 244


>I7IGH8_BABMI (tr|I7IGH8) Chromosome II, complete genome OS=Babesia microti
           strain RI GN=BBM_II03680 PE=3 SV=1
          Length = 507

 Score =  440 bits (1131), Expect = e-121,   Method: Compositional matrix adjust.
 Identities = 231/504 (45%), Positives = 318/504 (63%), Gaps = 26/504 (5%)

Query: 31  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATS-DPGKKNAIVMGRKTWESIPLKYR 88
           + A+T + GIG +GKLPW+ L  DLK  ++ITTA   D   +N ++MGRKT+ SIP   R
Sbjct: 9   IYASTPNGGIGNEGKLPWKTLPRDLKHLQDITTAYGPDHSVQNVVIMGRKTYISIPKSSR 68

Query: 89  PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 148
           PL  R+N+VL+ S S D G  + V+   S+             +   K+F+IGG  +++E
Sbjct: 69  PLKDRINIVLSSSVS-DFG--DGVIAAKSMQDAFDKLEK----MKFNKIFIIGGSSVYKE 121

Query: 149 VLNAPGCEAIHFTEIHASIECDTFM---PPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 205
             +    E ++ T ++  +  DTF+   PP+    +++   S     NDI + F  Y+  
Sbjct: 122 AYDLGIVEKVYVTRVNKELPADTFVTSVPPI----FEIVGISRTFSYNDIPFDFIIYMLK 177

Query: 206 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 265
            S A  ++  + D       +   F+ Q F  LP + +++HEE  YL +I +I+S     
Sbjct: 178 DSRATSNVCVDIDDYLLTEHEIRDFKYQ-FKALPNVTIRKHEEIQYLDIIADILSSGSEN 236

Query: 266 XXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIH 325
                   LSKFG +M FNL  SFPLLTTKKVF++G+VEELLWFI G T+ K+L EKG+ 
Sbjct: 237 DDRTGVGVLSKFGYKMEFNLDESFPLLTTKKVFFKGIVEELLWFIKGDTSGKILLEKGVR 296

Query: 326 IWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDY-------SGQGYDQ 378
           IW+ N +RE+LDS+GL ER+E DLGP+YGFQWRHFGA Y D   +Y       SGQG DQ
Sbjct: 297 IWEKNGTREFLDSVGLNERKEHDLGPIYGFQWRHFGAEYKDCDTNYTYILVNSSGQGIDQ 356

Query: 379 LLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMG 438
           L++ I+KIK++PN RRII+ +WN  DL  MALPPCH   QF+V+ G LSC MYQRSAD+G
Sbjct: 357 LMEAIDKIKNDPNSRRIIVCSWNVNDLSKMALPPCHCLFQFYVSQGRLSCIMYQRSADVG 416

Query: 439 LGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLK 498
           LGVPFNIASY+LLT MIA VC L PG FVHV+G+AH+Y  H+  L +Q+  +P PFP LK
Sbjct: 417 LGVPFNIASYSLLTLMIAQVCALRPGKFVHVLGNAHIYKTHITALTKQIQRIPYPFPILK 476

Query: 499 INSEKKDIDSFVAADFKLVGYNPH 522
           +N+++  I+ FV +D  L+ Y  H
Sbjct: 477 LNAQR--IEDFVPSDINLLCYTCH 498


>H8ZWN9_9EUKA (tr|H8ZWN9) Dihydrofolate reductase-thymidylate synthase (Fragment)
           OS=Collodictyon triciliatum PE=2 SV=1
          Length = 385

 Score =  433 bits (1113), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 214/408 (52%), Positives = 268/408 (65%), Gaps = 28/408 (6%)

Query: 57  FKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICG 116
           F+  T+A +D  K+NA++MGRKTW+SIP   RPL  RLNV+++ S   +     N+ +  
Sbjct: 1   FRTKTSALNDSSKRNALIMGRKTWDSIPQNRRPLANRLNVIVS-STFVNTEKNPNIEVVS 59

Query: 117 SIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPV 176
           +            Y   IE VFVIGGGQI++E + +P C++I  T++ A IECDTF P +
Sbjct: 60  TFEDAHELVSLGKYKREIENVFVIGGGQIYKEAIESPYCKSISLTKVFADIECDTFFPKI 119

Query: 177 DSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFD 236
           +   ++   SS  K EN IRY      R+ +    SL  NT                   
Sbjct: 120 NPDIFKTSTSSDIKEENSIRYQITQLERI-TQPQTSLVINT------------------- 159

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKK 296
                  QRHEE+ YL L++ I++E            +S FG QMRF+LR SFPLLTTK+
Sbjct: 160 -------QRHEEHQYLDLVRRILTEGVFKSDRTGVGTVSLFGAQMRFSLRESFPLLTTKR 212

Query: 297 VFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQ 356
           VFWRGV EELLWFISG+T+AK LQ+K I IWDGN+SREYLD IGL  RE GDLGPVYGFQ
Sbjct: 213 VFWRGVAEELLWFISGNTSAKSLQDKNIRIWDGNSSREYLDKIGLNHREVGDLGPVYGFQ 272

Query: 357 WRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMF 416
           WRHFGA Y  MH DY+G+G+DQL  +I  ++ NPNDRR+I+SAWNP DL+ MALPPCH+ 
Sbjct: 273 WRHFGAAYETMHTDYTGRGFDQLRSIIETLQKNPNDRRMIMSAWNPPDLQHMALPPCHIL 332

Query: 417 AQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPG 464
           +QF+VANGELSCQMYQRS DMGLGVPFNIASYALLTC+IA   +L  G
Sbjct: 333 SQFYVANGELSCQMYQRSCDMGLGVPFNIASYALLTCLIAQGLDLSLG 380


>Q582G3_TRYB2 (tr|Q582G3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Trypanosoma brucei brucei (strain 927/4
           GUTat10.1) GN=Tb927.7.5480 PE=3 SV=1
          Length = 527

 Score =  432 bits (1112), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 230/521 (44%), Positives = 309/521 (59%), Gaps = 53/521 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + VVVA+ +  GIG  G +PW +  D+++F+ +TT          P K+NA+VMGRKT
Sbjct: 27  RPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKT 86

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSFD---------IGTAEN----VVICGSIXXXXXXXX 126
           W+S+P K+RPL  RLNVVL+RS + +         I  AE     V + G +        
Sbjct: 87  WDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLV 146

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIH-ASIECDTFMPPVDSTKYQ 182
              +  SIE VF IGGG I+++ L AP     +AIH T +  AS  C  F          
Sbjct: 147 SKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFF--------- 197

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 242
                      DI  +    +       ES+   TD      +   K++ +      +++
Sbjct: 198 -----------DIPAAGTKTLEGLELVRESI---TDERVSTGAGGKKYQFE------KLV 237

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRG 301
            +  EE  YL L+  II E             S FG QMRF+LR +  PLLTTK+VFWRG
Sbjct: 238 PRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRG 297

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V EELLWF+ G TNAK+L +KGIHIWDGN SR +LDS GLT+ +E DLGPVYGFQWRHFG
Sbjct: 298 VCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFG 357

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A Y    +D  G+G DQ+ +++  +  NP+DRR+I +AWNP  L  MALPPCHM AQF+V
Sbjct: 358 ADYISCKEDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYV 417

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           +NGELSC +YQRS DMGLGVPFNIASYALLT ++A    L PG+ VH +GDAHVY NHV 
Sbjct: 418 SNGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVE 477

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           P ++QL  +P+PFP +    +K+ ++ F  +D +++ Y+P+
Sbjct: 478 PCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPY 518


>Q8MXB7_LEITR (tr|Q8MXB7) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania tropica GN=dhfr-ts PE=3 SV=1
          Length = 520

 Score =  432 bits (1110), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 230/526 (43%), Positives = 305/526 (57%), Gaps = 59/526 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFD----------IGTAEN--VVICGSIXXXXX 123
           GRKTWES+P+K+RPL GRLN+VL+   + +             AE   VV+ G +     
Sbjct: 80  GRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEEKRAAAEQDVVVVNGGLAEALR 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDST 179
                PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P     
Sbjct: 140 LLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP----- 194

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                   FP       +  A+    + S AE L               +FE+  +    
Sbjct: 195 --------FPPENAATAWDLASSQGRRKSEAEGL---------------EFEICKY---- 227

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
             + + HEE  YL LI  I+              +S FG QMRF+LR    PLLTTK+VF
Sbjct: 228 --VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRGNRLPLLTTKRVF 285

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNA++L +K IHIWDGN SRE+LDS GLTE +E DLGPVYGFQWR
Sbjct: 286 WRGVCEELLWFLRGETNARLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWR 345

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y     +Y G+G DQ+  ++  IK NPNDRR++++AWNP  L+ MALPPCH+ AQ
Sbjct: 346 HFGADYKGFEANYDGEGVDQIRFIVETIKANPNDRRLLVTAWNPCALQKMALPPCHLLAQ 405

Query: 419 FFVA--NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVY 476
           F+V     ELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY
Sbjct: 406 FYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVY 465

Query: 477 HNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            NHV  L+ QL  +P  FPTL   +E++ ++ +   D +++ Y PH
Sbjct: 466 RNHVDALKAQLERVPHAFPTLIFKAERQFLEDYELTDMEVIDYVPH 511


>C9ZTK8_TRYB9 (tr|C9ZTK8) Dihydrofolate reductase-thymidylate synthase
           OS=Trypanosoma brucei gambiense (strain
           MHOM/CI/86/DAL972) GN=TbgDal_VII6360 PE=3 SV=1
          Length = 527

 Score =  431 bits (1108), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 230/521 (44%), Positives = 308/521 (59%), Gaps = 53/521 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + VVVA+ +  GIG  G +PW +  D+++F+ +TT          P K+NA+VMGRKT
Sbjct: 27  RPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKT 86

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSFD---------IGTAEN----VVICGSIXXXXXXXX 126
           W+S+P K+RPL  RLNVVL+RS + +         I  AE     V + G +        
Sbjct: 87  WDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLV 146

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIH-ASIECDTFMPPVDSTKYQ 182
              +  SIE VF IGGG I+++ L AP     +AIH T +  AS  C  F          
Sbjct: 147 SKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFF--------- 197

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 242
                      DI  +    +       ES+   TD      +   K++ +      +++
Sbjct: 198 -----------DIPAAGTKTLEGLELVRESI---TDERVSTGAGGKKYQFE------KLV 237

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRG 301
            +  EE  YL L+  II E             S FG QMRF+LR +  PLLTTK+VFWRG
Sbjct: 238 PRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRG 297

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V EELLWF+ G TNAK+L +KGIHIWDGN SR +LDS GLT+ +E DLGPVYGFQWRHFG
Sbjct: 298 VCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFG 357

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A Y     D  G+G DQ+ +++  +  NP+DRR+I +AWNP  L  MALPPCHM AQF+V
Sbjct: 358 ADYISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYV 417

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           +NGELSC +YQRS DMGLGVPFNIASYALLT ++A    L PG+ VH +GDAHVY NHV 
Sbjct: 418 SNGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVE 477

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           P ++QL  +P+PFP +    +K+ ++ F  +D +++ Y+P+
Sbjct: 478 PCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPY 518


>Q8MXB8_LEITR (tr|Q8MXB8) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania tropica GN=dhfr-ts PE=3 SV=1
          Length = 520

 Score =  431 bits (1107), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 230/526 (43%), Positives = 304/526 (57%), Gaps = 59/526 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFD----------IGTAEN--VVICGSIXXXXX 123
           GRKTWES+P+K+RPL GRLN+VL+   + +             AE   VV+ G +     
Sbjct: 80  GRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEEKRAAAEQDVVVVNGGLAEALR 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDST 179
                PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P     
Sbjct: 140 LLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP----- 194

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                   FP       +  A+    + S AE L               +FE+  +    
Sbjct: 195 --------FPPENAATAWDLASSQGRRKSEAEGL---------------EFEICKY---- 227

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
             + + HEE  YL LI  I+              +S FG QMRF+LR    PLLTTK+VF
Sbjct: 228 --VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRGNRLPLLTTKRVF 285

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNA +L +K IHIWDGN SRE+LDS GLTE +E DLGPVYGFQWR
Sbjct: 286 WRGVCEELLWFLRGETNAXLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWR 345

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y     +Y G+G DQ+  ++  IK NPNDRR++++AWNP  L+ MALPPCH+ AQ
Sbjct: 346 HFGADYKGFEANYDGEGVDQIRFIVETIKANPNDRRLLVTAWNPCALQKMALPPCHLLAQ 405

Query: 419 FFVA--NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVY 476
           F+V     ELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY
Sbjct: 406 FYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVY 465

Query: 477 HNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            NHV  L+ QL  +P  FPTL   +E++ ++ +   D +++ Y PH
Sbjct: 466 RNHVDALKAQLERVPHAFPTLIFKAERQFLEDYELTDMEVIDYVPH 511


>E9AKW4_LEIMU (tr|E9AKW4) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania mexicana (strain MHOM/GT/2001/U1103)
           GN=LMXM_06_0860 PE=3 SV=1
          Length = 520

 Score =  430 bits (1105), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 229/526 (43%), Positives = 301/526 (57%), Gaps = 59/526 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTDKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFD------------IGTAENVVICGSIXXXXX 123
           GRKTWES+P+K+RPL GRLNVVL+   + +                + VV+ G +     
Sbjct: 80  GRKTWESVPVKFRPLKGRLNVVLSSKATVEELLAPLPEEKRAAAAQDIVVVNGGLAAALR 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDST 179
                PYC SIE  + +GG Q++ + + +P  E    ++ T IH +   C  F P     
Sbjct: 140 LLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIHTTAPACTRFFP----- 194

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                   FP       +  A+    + SA                D L+FE+  +    
Sbjct: 195 --------FPPENAATAWDLASSQGRRKSAV---------------DGLEFEICKY---- 227

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
             + + HEE  YL LI  I+              LS FG QMRF+LR    PLLTTK+VF
Sbjct: 228 --VPRNHEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLRDNRLPLLTTKRVF 285

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNA++L +K IHIWDGN SRE+LDS GLTE  E DLGPVYGFQWR
Sbjct: 286 WRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENTEMDLGPVYGFQWR 345

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y  +  +Y G+G DQ+  ++  IK NPNDRR++ +AWNP  L  MALPPCH+ AQ
Sbjct: 346 HFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTAWNPCALHKMALPPCHLLAQ 405

Query: 419 FFV--ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVY 476
           F+V     ELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY
Sbjct: 406 FYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVY 465

Query: 477 HNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            +H+  L+ QL  +P  FPTL    E++ ++ +   D +++ Y PH
Sbjct: 466 RSHIGALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVIDYVPH 511


>Q8T5T9_TRYCR (tr|Q8T5T9) Dihydrofolate reductase-thymidylate synthase
           OS=Trypanosoma cruzi PE=3 SV=1
          Length = 521

 Score =  428 bits (1101), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 228/527 (43%), Positives = 301/527 (57%), Gaps = 65/527 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 140

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 183

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 184 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 225

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 226 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 285

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 286 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 345

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 346 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 405

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 406 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 465

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           Y NHV P  EQL  +P+ FP L    E++ ++ +   D +++ Y P+
Sbjct: 466 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPY 512


>Q8T5T8_TRYCR (tr|Q8T5T8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Trypanosoma cruzi GN=TCSYLVIO_001858 PE=1
           SV=1
          Length = 521

 Score =  428 bits (1101), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 228/527 (43%), Positives = 301/527 (57%), Gaps = 65/527 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 140

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 183

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 184 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 225

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 226 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 285

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 286 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 345

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 346 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 405

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 406 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 465

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           Y NHV P  EQL  +P+ FP L    E++ ++ +   D +++ Y P+
Sbjct: 466 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPY 512


>Q4DLS1_TRYCC (tr|Q4DLS1) Dihydrofolate reductase-thymidylate synthase, putative
           OS=Trypanosoma cruzi (strain CL Brener)
           GN=Tc00.1047053509153.90 PE=3 SV=1
          Length = 521

 Score =  427 bits (1099), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 228/527 (43%), Positives = 301/527 (57%), Gaps = 65/527 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 140

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 183

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 184 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 225

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 226 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 285

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 286 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 345

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 346 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 405

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 406 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 465

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           Y NHV P  EQL  +P+ FP L    E++ ++ +   D +++ Y P+
Sbjct: 466 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPY 512


>Q8MQV3_LEIIN (tr|Q8MQV3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Leishmania infantum GN=DHFR-TS PE=3 SV=1
          Length = 520

 Score =  427 bits (1097), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 228/526 (43%), Positives = 302/526 (57%), Gaps = 59/526 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFD------------IGTAENVVICGSIXXXXX 123
           GRKTWES+P+K+RPL GRLN+VL+   + +                + VV+ G +     
Sbjct: 80  GRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNGGLAEALR 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDST 179
                PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P     
Sbjct: 140 LLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP----- 194

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                   FP       +  A+    + S A               D L+FE+  +    
Sbjct: 195 --------FPPENTTTAWDLASSQGRRKSEA---------------DGLEFEICKY---- 227

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
             + + HEE  YL LI  I+              +S FG QMRF+LR    PLLTTK+VF
Sbjct: 228 --VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVF 285

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNA++L +K IHIWDGN SRE+LDS GLTE +E DLGPVYGFQWR
Sbjct: 286 WRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWR 345

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y     +Y G+G DQ+  ++  IK NPNDRR++ +AWNP  L+ MALPPCH+ AQ
Sbjct: 346 HFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQ 405

Query: 419 FFVA--NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVY 476
           F+V     ELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY
Sbjct: 406 FYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVY 465

Query: 477 HNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            NHV  L+ QL  +P  FPTL    E++ ++ +   D +++ Y PH
Sbjct: 466 RNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPH 511


>Q8MQV1_LEICH (tr|Q8MQV1) Dhfr-ts OS=Leishmania chagasi PE=3 SV=1
          Length = 520

 Score =  426 bits (1096), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 229/526 (43%), Positives = 303/526 (57%), Gaps = 59/526 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTA------------ENVVICGSIXXXXX 123
           GRKTWES+P+K+RPL GRLN+VL+   + +   A            + VV+ G +     
Sbjct: 80  GRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNGGLAEALR 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDST 179
                PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P     
Sbjct: 140 LLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP----- 194

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                   FP       +  A+    + S A               D L+FE+  +    
Sbjct: 195 --------FPPENTTTAWDLASSQGRRKSEA---------------DGLEFEICKY---- 227

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
             + + HEE  YL LI  I+              +S FG QMRF+LR    PLLTTK+VF
Sbjct: 228 --VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVF 285

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNA++L +K IHIWDGN SRE+LDS GLTE +E DLGPVYGFQWR
Sbjct: 286 WRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWR 345

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y     +Y G+G DQ+  ++  IK NPNDRR++ +AWNP  L+ MALPPCH+ AQ
Sbjct: 346 HFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQ 405

Query: 419 FFVA--NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVY 476
           F+V     ELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY
Sbjct: 406 FYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVY 465

Query: 477 HNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            NHV  L+ QL  +P  FPTL    E++ ++ +   D +++ Y PH
Sbjct: 466 RNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPH 511


>K2NID0_TRYCR (tr|K2NID0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Trypanosoma cruzi marinkellei GN=MOQ_000668
           PE=3 SV=1
          Length = 521

 Score =  426 bits (1096), Expect = e-117,   Method: Compositional matrix adjust.
 Identities = 230/521 (44%), Positives = 304/521 (58%), Gaps = 53/521 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + ++VA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLIVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLYADSIVAVNGGLEQALQLLA 140

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 182
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F    +S    
Sbjct: 141 SLNYTSSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFHVPES---- 196

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 242
               + P          A  +  Q    E++S+    L   N    K+      +  ++I
Sbjct: 197 ---GTEP----------AAGIEWQR---ETISEE---LTSANGSETKY------YFEKLI 231

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRG 301
            +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK+VFWRG
Sbjct: 232 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRG 291

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGFQWRHFG
Sbjct: 292 VCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFG 351

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+ AQF+V
Sbjct: 352 ADYTHHDANYDGQGVDQIKTIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYV 411

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           +NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY NHV 
Sbjct: 412 SNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVE 471

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           P +EQL  +P+ FP L    E++ ++ +   D +++ Y P+
Sbjct: 472 PCKEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYTPY 512


>H9AZH4_TRYCR (tr|H9AZH4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 508

 Score =  424 bits (1091), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 227/524 (43%), Positives = 299/524 (57%), Gaps = 65/524 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 19  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 78

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 79  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 138

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 139 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 181

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 182 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 223

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 224 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 283

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 284 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 343

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 344 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 403

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 404 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 463

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGY 519
           Y NHV P  EQL  +P+ FP L    E++ ++ +   D +++ Y
Sbjct: 464 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDY 507


>A4H4P8_LEIBR (tr|A4H4P8) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania braziliensis GN=LBRM_06_0830 PE=3 SV=1
          Length = 521

 Score =  424 bits (1090), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 226/527 (42%), Positives = 306/527 (58%), Gaps = 60/527 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + ++VA  +  GIG    +PW++  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RCFSIIVAVDEQHGIGDGKTIPWQVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFD------------IGTAENVVICGSIXXXXX 123
           GR+TWES+PLKYRPL GRLNVVL+   + D                + VV+ G +     
Sbjct: 80  GRQTWESVPLKYRPLKGRLNVVLSSKATVDELLAALPEGKRTAAAQDLVVVNGGLAEALH 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMP-PVDS 178
                P+C SIE  + +GG Q++ + + AP  E    ++ T I+A+  EC  F P P  +
Sbjct: 140 LLARPPHCSSIETAYCVGGAQVYSDAMTAPCVEKLQEVYLTRIYATAPECTRFYPFPPTN 199

Query: 179 TKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFL 238
                W         D+ +   T  R +S                 +  +++E++ +   
Sbjct: 200 AAAAAW---------DLAW---TQGRQRS----------------ETGGVEYEIRKY--- 228

Query: 239 PEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKV 297
              +   HEE  YL LI  I+              LS FG QMRF+LR    PLLTTK+V
Sbjct: 229 ---VPHNHEERQYLELIDRIMKTGIAKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRV 285

Query: 298 FWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQW 357
           FWRGV EELLWF+ G TNA++L +K IHIWDGN SRE+LDS GLT  +E DLGPVYGFQW
Sbjct: 286 FWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQW 345

Query: 358 RHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFA 417
           RHFGA+Y     +Y G+G DQ+  ++  IK NPNDRR++L+AWNP  L  MALPPCH+ A
Sbjct: 346 RHFGAQYKGFEANYDGEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLA 405

Query: 418 QFFVANG--ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
           QF+V     ELSC +YQRS DMGLGVPFNIASYALLT ++A    L PG+ VH +GDAHV
Sbjct: 406 QFYVNTDAKELSCMLYQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHV 465

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           Y NH+  L+ QL   P  FPTL    E++ ++ +  +D +++ Y P+
Sbjct: 466 YRNHIDALKVQLERTPNAFPTLVFKREREFLEDYELSDMEVIDYAPY 512


>H9AZH1_TRYCR (tr|H9AZH1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 508

 Score =  424 bits (1090), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 227/524 (43%), Positives = 299/524 (57%), Gaps = 65/524 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 19  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 78

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 79  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 138

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 139 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 181

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 182 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 223

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 224 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 283

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 284 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 343

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 344 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 403

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 404 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 463

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGY 519
           Y NHV P  EQL  +P+ FP L    E++ ++ +   D +++ Y
Sbjct: 464 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDY 507


>E9B8U9_LEIDB (tr|E9B8U9) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania donovani (strain BPK282A1) GN=LDBPK_060890
           PE=3 SV=1
          Length = 520

 Score =  424 bits (1089), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 228/526 (43%), Positives = 302/526 (57%), Gaps = 59/526 (11%)

Query: 21  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVM 75
            P+L R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VM
Sbjct: 21  FPSL-RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVM 79

Query: 76  GRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTA------------ENVVICGSIXXXXX 123
           GRKTWES+P+K+RPL GRLN+VL+   + +   A            + VV+   +     
Sbjct: 80  GRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNDGLAEALR 139

Query: 124 XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDST 179
                PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P     
Sbjct: 140 LLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP----- 194

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP 239
                   FP       +  A+    + S A               D L+FE+  +    
Sbjct: 195 --------FPPENTTTAWDLASSQGRRKSEA---------------DGLEFEICKY---- 227

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVF 298
             + + HEE  YL LI  I+              +S FG QMRF+LR    PLLTTK+VF
Sbjct: 228 --VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVF 285

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           WRGV EELLWF+ G TNA++L +K IHIWDGN SRE+LDS GLTE +E DLGPVYGFQWR
Sbjct: 286 WRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWR 345

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           HFGA Y     +Y G+G DQ+  ++  IK NPNDRR++ +AWNP  L+ MALPPCH+ AQ
Sbjct: 346 HFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQ 405

Query: 419 FFVA--NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVY 476
           F+V     ELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY
Sbjct: 406 FYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVY 465

Query: 477 HNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            NHV  L+ QL  +P  FPTL    E++ ++ +   D +++ Y PH
Sbjct: 466 RNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPH 511


>L0B0P3_BABEQ (tr|L0B0P3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Babesia equi GN=BEWA_008170 PE=3 SV=1
          Length = 511

 Score =  424 bits (1089), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 215/501 (42%), Positives = 306/501 (61%), Gaps = 17/501 (3%)

Query: 29  QVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEIT------TATSDPGKKNAIVMGRKTWE 81
           Q+VVA T   GIG    LPW  +  D  F   IT          D   +N ++ GR T+ 
Sbjct: 12  QIVVAVTPKNGIGLKNNLPWPHIKKDFLFLSRITNYIEHEVKKKDQNLQNVVIFGRNTYF 71

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           S+P    PL  R+NVV++++    +     V++  ++             +   K+F++G
Sbjct: 72  SLPPSAAPLKNRINVVISKT----VREIPGVLVYETLPLALKKIQEE---VKYNKIFILG 124

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           G  +++E +++  CE I+ T I  + E D F P +  + Y++   S     +D  + F  
Sbjct: 125 GSYLYKEAIDSGLCEKIYLTRIAKNYEADVFFPQLPDS-YEIVGISKTFGTDDTTFDFVI 183

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           Y + ++   ES   + D L     + L  E   +   P + ++ ++E  YL ++ +I++ 
Sbjct: 184 YEK-KNVNKESELPDLDKLI-LTGEKLTVETPLYKACPSLKIRYNQELQYLDILADILNN 241

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                       ++KFG QMRF+L  SFPLLTTKKVF RG++EEL+WFI GSTN   L E
Sbjct: 242 GTEKPNRTGINSIAKFGYQMRFDLSESFPLLTTKKVFLRGIIEELIWFIRGSTNGNELLE 301

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           K + IW+ N +RE+LD++G  +REE DLGPVYGFQWRHFGA+Y +MH DY+GQG DQL  
Sbjct: 302 KNVRIWELNGAREFLDNLGFVDREEHDLGPVYGFQWRHFGAKYVNMHTDYTGQGIDQLSI 361

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VI++IK+NPNDRR+I+ +WN  DL  MALPPCH+  QFFVA+G LSC M+QRS DMGLGV
Sbjct: 362 VIDRIKNNPNDRRLIVCSWNVSDLSKMALPPCHLLFQFFVADGRLSCMMHQRSCDMGLGV 421

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASYALLTCM+A +CEL PG+FVH +GDAH+Y NH+  ++EQ+  +P PFPTL++N 
Sbjct: 422 PFNIASYALLTCMMAQICELKPGEFVHNLGDAHIYSNHIDAMKEQISRIPYPFPTLRLNK 481

Query: 502 EKKDIDSFVAADFKLVGYNPH 522
           +   I+ F   D K+  Y  H
Sbjct: 482 DITRIEDFTLEDVKVENYLSH 502


>B5U9U8_BABGI (tr|B5U9U8) Dihydrofolate reductase-thymidylate synthase OS=Babesia
           gibsoni GN=Bgdhfr-ts PE=2 SV=1
          Length = 515

 Score =  423 bits (1087), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 223/501 (44%), Positives = 307/501 (61%), Gaps = 17/501 (3%)

Query: 29  QVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITT------ATSDPGKKNAIVMGRKTWE 81
           Q++VA   +  IGK+ ++PW  +  D +F   +TT         +P  KN ++ GRKT+E
Sbjct: 11  QIIVATALNRVIGKNNEIPWPHIRQDFRFLYWVTTFIEPEVKAKNPELKNVVIFGRKTYE 70

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 141
           SIP    PL GR+NV+++RS    I     V+   S+             +   K+F++G
Sbjct: 71  SIPQNVLPLKGRINVLISRS----IKEMPGVLTFSSLDAAIKELRA---SVPHNKIFILG 123

Query: 142 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 201
           G +I+R VL    C+ I+ T I+   E D F P +  T +++   S     + + Y F T
Sbjct: 124 GSEIYRLVLENDLCDKIYQTRINKDYEGDRFFPEIPDT-FEITGISKTFGTDFVTYDFVT 182

Query: 202 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 261
           Y + +S   +    + D L     +  K +V  +   P + ++ HEE+ YL ++ +++S 
Sbjct: 183 YEK-KSVVKDKPHPSMDELVLTGEEP-KVKVPQYVACPSVKIRYHEEFQYLDILADVLSN 240

Query: 262 XXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQE 321
                        SKFG QMRF+L +SFPLLTTKKV  R ++EELLWFI GSTN   L  
Sbjct: 241 GTLKQNRTGTDAYSKFGYQMRFDLSKSFPLLTTKKVALRSIIEELLWFIRGSTNGNDLLA 300

Query: 322 KGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLD 381
           K + IW+ N +R +LD++G T+REE DLGPVYGFQWRHFGA+Y DMH DYSGQG DQL  
Sbjct: 301 KNVRIWELNGARSFLDNLGFTDREEHDLGPVYGFQWRHFGAKYLDMHADYSGQGIDQLKT 360

Query: 382 VINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGV 441
           VI KIK NPNDRR+I+ +WN  DL  MALPPCH F QF+V +G+LSC M+QRS D+GLGV
Sbjct: 361 VIEKIKTNPNDRRLIVCSWNVADLGKMALPPCHCFFQFYVKDGKLSCLMHQRSCDLGLGV 420

Query: 442 PFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINS 501
           PFNIASY++LT MIA VC L  G+FVH + DAHVY +HV P++ Q+  +P PFP LK+N 
Sbjct: 421 PFNIASYSILTAMIAQVCGLQLGEFVHNLADAHVYVDHVEPVKLQMSRVPYPFPQLKLNP 480

Query: 502 EKKDIDSFVAADFKLVGYNPH 522
           + KDI+ F   D ++V Y  H
Sbjct: 481 DVKDIEGFTIDDIQVVNYVSH 501


>I6LEA2_TRYCR (tr|I6LEA2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  421 bits (1081), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 225/514 (43%), Positives = 295/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T+AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETHAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>I6LEA8_TRYCR (tr|I6LEA8) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  421 bits (1081), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 228/508 (44%), Positives = 297/508 (58%), Gaps = 53/508 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 182
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F          
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFF--------- 182

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 242
                 P+   +     A  +  Q    E++S+    L   N +  K+      +  ++I
Sbjct: 183 ----RVPEAGTEA----AAGIEWQR---ETISEE---LTSANGNETKY------YFEKLI 222

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRG 301
            +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK+VFWRG
Sbjct: 223 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRG 282

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGFQWRHFG
Sbjct: 283 VCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFG 342

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+ AQF+V
Sbjct: 343 AAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYV 402

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           +NGELSC +YQRS DMGLGVPFNIASYALLT +IA V  L PG+ VH +GDAHVY NHV 
Sbjct: 403 SNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKVTGLRPGELVHTLGDAHVYSNHVE 462

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           P  EQL  +P+ FP L    E++ ++ +
Sbjct: 463 PCNEQLKRVPRAFPYLVFRREREFLEDY 490


>Q963S7_9TRYP (tr|Q963S7) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma vespertilionis
           GN=DHFR-TS PE=3 SV=1
          Length = 491

 Score =  419 bits (1078), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 228/507 (44%), Positives = 299/507 (58%), Gaps = 51/507 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFFK++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFKDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLQDEEKRNLYADSIVAVNGGLEQALQLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS          +S+    
Sbjct: 131 SLNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------ESSCSVF 180

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMIL 243
           ++   P  E       A  +  Q    E++S+    L   N +  K+      +  ++I 
Sbjct: 181 FHVPEPGTEP------AAGIEWQR---ETISEE---LTSANGNETKY------YFEKLIP 222

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK+VFWRGV
Sbjct: 223 RNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGV 282

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
            EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGFQWRHFGA
Sbjct: 283 CEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGA 342

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+ AQF+V+
Sbjct: 343 AYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVS 402

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY NHV P
Sbjct: 403 NGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEP 462

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSF 509
            +EQL  +P+ FP L    E++ ++ +
Sbjct: 463 CKEQLKRVPRAFPYLVFRREREFLEDY 489


>Q95NI3_TRYCR (tr|Q95NI3) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  419 bits (1078), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/514 (43%), Positives = 294/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 275

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 276 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 335

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 336 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 395

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 396 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 455

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 456 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489


>Q0IK63_TRYCR (tr|Q0IK63) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  419 bits (1078), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/514 (43%), Positives = 294/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>I6LEA0_TRYCR (tr|I6LEA0) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  419 bits (1077), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 226/508 (44%), Positives = 294/508 (57%), Gaps = 53/508 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 182
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F    +S    
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGT-- 189

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 242
                  +    I +   T    ++SA              N +  K+      +  ++I
Sbjct: 190 -------EAAAGIEWQRETISEERTSA--------------NGNETKY------YFEKLI 222

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRG 301
            +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK+VFWRG
Sbjct: 223 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRG 282

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGFQWRHFG
Sbjct: 283 VCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFG 342

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+ AQF+V
Sbjct: 343 AAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYV 402

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           +NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY NHV 
Sbjct: 403 SNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVE 462

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           P  EQL  +P+ FP L    E++ ++ +
Sbjct: 463 PCNEQLKRVPRAFPYLVFRREREFLEDY 490


>Q95NS0_TRYCR (tr|Q95NS0) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  419 bits (1077), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/514 (43%), Positives = 294/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 275

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 276 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 335

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 336 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 395

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 396 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 455

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 456 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489


>I6LEA3_TRYCR (tr|I6LEA3) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  419 bits (1076), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/514 (43%), Positives = 294/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>Q95NX3_TRYCR (tr|Q95NX3) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  419 bits (1076), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/514 (43%), Positives = 294/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 275

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 276 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 335

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 336 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 395

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 396 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 455

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 456 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489


>D3JL87_TRYCR (tr|D3JL87) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  418 bits (1074), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/509 (44%), Positives = 291/509 (57%), Gaps = 65/509 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           Y NHV P  EQL  +P+ FP L    E++
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRERE 477


>D3JLA1_TRYCR (tr|D3JLA1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  418 bits (1074), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/509 (44%), Positives = 291/509 (57%), Gaps = 65/509 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           Y NHV P  EQL  +P+ FP L    E++
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRERE 477


>D3JL82_TRYCR (tr|D3JL82) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 478

 Score =  418 bits (1074), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/509 (44%), Positives = 291/509 (57%), Gaps = 65/509 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           Y NHV P  EQL  +P+ FP L    E++
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRERE 477


>Q95NY4_TRYCR (tr|Q95NY4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi marinkellei
           GN=DHFR-TS PE=3 SV=1
          Length = 491

 Score =  417 bits (1073), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 227/508 (44%), Positives = 298/508 (58%), Gaps = 53/508 (10%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + ++VA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLIVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLYADSIVAVNGGLEQALQLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 182
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F    +S    
Sbjct: 131 SLNYTSSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFHVPES---- 186

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 242
               + P          A  +  Q    E++S+    L   N    K+      +  ++I
Sbjct: 187 ---GTEP----------AAGIEWQR---ETISEE---LTSANGSETKY------YFEKLI 221

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRG 301
            +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK+VFWRG
Sbjct: 222 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRG 281

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGFQWRHFG
Sbjct: 282 VCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFG 341

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+ AQF+V
Sbjct: 342 ADYTHHDANYDGQGVDQIKTIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYV 401

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
           +NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY NHV 
Sbjct: 402 SNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVE 461

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           P +EQL  +P+ FP L  + E++ ++ +
Sbjct: 462 PCKEQLKRVPRAFPYLVFHREREFLEDY 489


>Q95NT2_TRYCR (tr|Q95NT2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  417 bits (1073), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 293/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 275

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 276 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 335

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 336 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 395

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYA LT +IA    L PG+ VH +GDAHV
Sbjct: 396 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYAFLTILIAKATGLRPGELVHTLGDAHV 455

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 456 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489


>D3JLB2_TRYCR (tr|D3JLB2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  417 bits (1073), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/508 (44%), Positives = 290/508 (57%), Gaps = 65/508 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 5   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 64

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 65  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 124

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 125 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 167

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 168 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 209

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 210 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 269

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 270 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 329

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 330 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 389

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 390 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 449

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           Y NHV P  EQL  +P+ FP L    E+
Sbjct: 450 YSNHVEPCNEQLKRVPRAFPYLVFRRER 477


>D3JL86_TRYCR (tr|D3JL86) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 476

 Score =  417 bits (1073), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/508 (44%), Positives = 290/508 (57%), Gaps = 65/508 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           Y NHV P  EQL  +P+ FP L    E+
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRER 476


>I6LEA6_TRYCR (tr|I6LEA6) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  417 bits (1073), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 294/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD + SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDSGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>D3JL83_TRYCR (tr|D3JL83) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 476

 Score =  417 bits (1073), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 225/508 (44%), Positives = 290/508 (57%), Gaps = 65/508 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEK 503
           Y NHV P  EQL  +P+ FP L    E+
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRER 476


>D3JL96_TRYCR (tr|D3JL96) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  417 bits (1072), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 226/509 (44%), Positives = 293/509 (57%), Gaps = 65/509 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSFD------------IGTAENVV-ICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +                 A+++V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNSHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           Y NHV P  EQL  +P+ FP L    E++
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRERE 477


>I6LE99_TRYCR (tr|I6LE99) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  417 bits (1071), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 293/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  I  E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRITREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>D3JLB1_TRYCR (tr|D3JLB1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 471

 Score =  416 bits (1070), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 224/502 (44%), Positives = 288/502 (57%), Gaps = 65/502 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTL 497
           Y NHV P  EQL  +P+ FP L
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYL 470


>I6LEA1_TRYCR (tr|I6LEA1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  416 bits (1070), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 293/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QW HFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWHHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>D3JLA6_TRYCR (tr|D3JLA6) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  416 bits (1069), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 224/509 (44%), Positives = 290/509 (56%), Gaps = 65/509 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE  + IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETFYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 268

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 269 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 328

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 329 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 388

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 389 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 448

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKK 504
           Y NHV P  EQL  +P+ FP L    E++
Sbjct: 449 YSNHVEPCNEQLKRVPRAFPYLVFRRERE 477


>I6LEA5_TRYCR (tr|I6LEA5) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  416 bits (1069), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 293/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SI  V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>Q963S8_TRYCR (tr|Q963S8) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  416 bits (1069), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 293/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 130

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SI  V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR +  PLLTTK
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTK 275

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 276 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 335

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 336 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 395

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 396 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 455

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 456 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 489


>I6LEA7_TRYCR (tr|I6LEA7) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  416 bits (1068), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 224/514 (43%), Positives = 293/514 (57%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTIIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS F  QMRF+LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFDAQMRFSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>R4KZ58_NEOCA (tr|R4KZ58) Bifunctional dihydrofolate reductase/thymidylate
           synthase OS=Neospora caninum PE=2 SV=1
          Length = 641

 Score =  415 bits (1066), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 237/607 (39%), Positives = 323/607 (53%), Gaps = 106/607 (17%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDPGKK----------- 70
           N+Q+   ++ A T   GIG +  LPW  L TD K F  +T  T+D   +           
Sbjct: 29  NMQKPVSLIAAMTPRRGIGVNNGLPWPHLATDFKHFSRVTKTTADEVSRLNAWLPKKIAK 88

Query: 71  ----------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAEN--- 111
                           NA+VMGRKTWES+PLK+RPL  RLN+V++ S   +   AE    
Sbjct: 89  TGDSGLPSPAFGVNRFNAVVMGRKTWESLPLKFRPLVDRLNIVVSSSLKEEDIAAEKPLV 148

Query: 112 -----VVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHAS 166
                V +C S+           Y  S+++++V+GG  ++ E L+      ++ T +   
Sbjct: 149 EGQQRVRVCDSLPAALRLVDEE-YRESVDQIYVVGGAGLYEEALSLGVVSHLYITRVARD 207

Query: 167 IECDTFMP--PVDS-----------------------------------TKYQLWYSSFP 189
             CD F P  P DS                                     Y+  + S  
Sbjct: 208 FPCDVFFPAFPGDSILSNKQAASASQPSAAAEPVFVPFCPQLGREKSNEASYRPIFISKT 267

Query: 190 KVENDIRYSFATYVRVQSSAAESLSQN------------TDPLFDNNSDSLKFEVQNFDF 237
             +N + Y F    + + + A S +++            T P     S S     Q   +
Sbjct: 268 YSDNGVPYDFVVLEKGRKADACSATESCELRGPWTSTGETSPETRLPSSSASAVAQVLAW 327

Query: 238 LPEMILQRHEEYMYLR-----------------LIQEIISEXXXXXXXXXXXXLSKFGCQ 280
           + +   ++ E+   +R                 LI +II+             +SKFGC 
Sbjct: 328 MADEDRKKCEKKEIIRAVPHVHFRGHEEFQYLDLIADIINNGATMDDRTGVGVISKFGCT 387

Query: 281 MRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIG 340
           MRF+L ++FPLLTTK+VFW+GV+EELLWFI G TNA  L EKG+ IWD N +RE+LDS  
Sbjct: 388 MRFSLDKAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRN 447

Query: 341 LTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAW 400
           L+ RE GD+GP YGFQWRHFGA Y DMH DY+GQG DQL  VIN ++ NP DRR++++AW
Sbjct: 448 LSHREVGDIGPGYGFQWRHFGATYKDMHTDYTGQGVDQLKKVINMLRTNPTDRRMLMTAW 507

Query: 401 NPVDLKLMALPPCHMFAQFFVANG-ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC 459
           NP  L  MALPPCH+  QF+V N  +LSC MYQRS D+GLGVPFNIASY+LLT M+AHVC
Sbjct: 508 NPAALDEMALPPCHLLCQFYVENDRDLSCVMYQRSCDVGLGVPFNIASYSLLTLMVAHVC 567

Query: 460 ELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKI-NSEK-KDIDSFVAADFKLV 517
            L P +F+H +G+ HVY NHV  L+EQL   P+PFP + I N E+ ++ID F A DF++V
Sbjct: 568 NLKPKEFIHFMGNTHVYSNHVEALKEQLRREPRPFPIVNILNKERIQEIDDFTAEDFEVV 627

Query: 518 GYNPHQK 524
           GY PH +
Sbjct: 628 GYVPHGR 634


>R7V2Q2_9ANNE (tr|R7V2Q2) Uncharacterized protein OS=Capitella teleta
           GN=CAPTEDRAFT_148645 PE=4 SV=1
          Length = 310

 Score =  414 bits (1064), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 195/298 (65%), Positives = 224/298 (75%), Gaps = 4/298 (1%)

Query: 231 EVQNFDFLPEMILQ---RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR 287
           E++  + +P  IL+   RH+E+ YL  I+EII              +S FG Q R++LR 
Sbjct: 6   EIRTTEQIPGKILKSVKRHDEFQYLEAIEEIIQRGTKKGNRTGIDTISIFGMQSRYSLRN 65

Query: 288 S-FPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREE 346
              PLLTTK+VFWRGV EELLWFI GSTNAK L EKG+HIWDGN SREYLD +G TEREE
Sbjct: 66  GVLPLLTTKRVFWRGVAEELLWFIKGSTNAKSLSEKGVHIWDGNGSREYLDKMGFTEREE 125

Query: 347 GDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLK 406
           GDLGPVYGFQWRHFGA Y DMH DY+GQG DQL DVI+KIK+NP DRRIIL AWNP DL 
Sbjct: 126 GDLGPVYGFQWRHFGAEYKDMHADYTGQGIDQLADVIDKIKNNPEDRRIILCAWNPKDLP 185

Query: 407 LMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDF 466
            MALPPCH F QF+VANGELSCQ+YQRSADMGLGVPFNIASYALLTCMIAHV +L PGDF
Sbjct: 186 QMALPPCHAFVQFYVANGELSCQLYQRSADMGLGVPFNIASYALLTCMIAHVTDLQPGDF 245

Query: 467 VHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           VH IGDAH+Y NH+  L+EQL   P+ FP LK   +   I+ F   DF+++GY PH K
Sbjct: 246 VHTIGDAHIYCNHMEALEEQLKREPREFPELKFKRKVTSIEDFTFEDFEVIGYKPHPK 303


>Q4A320_EHV8U (tr|Q4A320) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Emiliania huxleyi virus 86 (isolate United
           Kingdom/English Channel/1999) GN=EhV113 PE=3 SV=1
          Length = 480

 Score =  414 bits (1064), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 225/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++TT+TS P  +N ++MG KTW+SI  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTTSTSMPICENVVIMGTKTWQSIG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDNCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T       +  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYKATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNMPKTIFDVTSDDIILNDYKCHPK 473


>G4YAN7_9PHYC (tr|G4YAN7) Thymidylate synthase OS=Emiliania huxleyi virus 88
           GN=EOVG_00115 PE=3 SV=1
          Length = 480

 Score =  414 bits (1063), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 225/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++TT+TS P  +N ++MG KTW+SI  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTTSTSMPICENVVIMGTKTWQSIG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDNCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T       +  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYKATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLRRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNMPKTIFDVTSDDIILNDYKCHPK 473


>G3GPB6_9PHYC (tr|G3GPB6) Thymidylate synthase OS=Emiliania huxleyi virus 84
           GN=ENVG_00370 PE=3 SV=1
          Length = 480

 Score =  414 bits (1063), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 225/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++TT+TS P  +N ++MG KTW+SI  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTTSTSMPICENVVIMGTKTWQSIG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDNCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T       +  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYKATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLRRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNMPKTIFDVTSDDIILNDYKCHPK 473


>I6LEA4_TRYCR (tr|I6LEA4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  413 bits (1061), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 223/514 (43%), Positives = 292/514 (56%), Gaps = 65/514 (12%)

Query: 26  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 79
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 80  WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 126
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 183
              Y  SI  V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 184 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 236
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 237 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTK 295
           +  ++I +  EE  YL L+  II E            LS FG QMR +LR +  PLLTTK
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRSSLRNNRLPLLTTK 276

Query: 296 KVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGF 355
           +VFWRGV EELLWF+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGF
Sbjct: 277 RVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGF 336

Query: 356 QWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHM 415
           QWRHFGA Y+    +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+
Sbjct: 337 QWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHL 396

Query: 416 FAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHV 475
            AQF+V+NGELSC +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHV
Sbjct: 397 LAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHV 456

Query: 476 YHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSF 509
           Y NHV P  EQL  +P+ FP L    E++ ++ +
Sbjct: 457 YSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDY 490


>D2TF54_9PHYC (tr|D2TF54) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Emiliania huxleyi virus 99B1 GN=EhV113 PE=3
           SV=1
          Length = 480

 Score =  412 bits (1060), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 225/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++TT+TS P  +N ++MG KTW+SI  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTTSTSMPICENVVIMGAKTWQSIG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDNCDTF---------------FPFTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T       +  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYKATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHIMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNMPKTIFDVTSDDIILNDYKCHPK 473


>D8LBA4_ECTSI (tr|D8LBA4) Putative uncharacterized protein OS=Ectocarpus
           siliculosus GN=Esi_0000_0340 PE=3 SV=1
          Length = 581

 Score =  412 bits (1060), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 188/279 (67%), Positives = 218/279 (78%), Gaps = 1/279 (0%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVE 304
            EE  YL L+++I+              LSKFG QMRF+LR   FPLLTTK+VFWRGV E
Sbjct: 295 EEEMQYLNLVEDILDNGVRRGDRTGTGTLSKFGVQMRFSLREERFPLLTTKRVFWRGVAE 354

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWF++G TNA VL+E+GIHIWDGN SRE+LD +GLTEREEGDLGPVYGFQWRHFGA Y
Sbjct: 355 ELLWFVAGCTNANVLKERGIHIWDGNGSREFLDGLGLTEREEGDLGPVYGFQWRHFGAEY 414

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
           +DMH DY+G+G DQL + I KIK NP DRRI+LSAWNP DL  MALPPCHMF QF+VA G
Sbjct: 415 TDMHADYTGKGVDQLAECIQKIKTNPEDRRIVLSAWNPADLGKMALPPCHMFCQFYVAEG 474

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQMYQRSADMGLGVPFNIASYALLT ++A  C L  GDFVH IGDAHVY NHV  L+
Sbjct: 475 ELSCQMYQRSADMGLGVPFNIASYALLTRLVAQACGLKAGDFVHTIGDAHVYVNHVDALR 534

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
           EQL   P+PFPTL IN+++ DIDSF     ++ GY+P++
Sbjct: 535 EQLKRKPRPFPTLSINTDETDIDSFEYKHLEVKGYSPYK 573



 Score =  117 bits (293), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 72/206 (34%), Positives = 109/206 (52%), Gaps = 21/206 (10%)

Query: 22  PNLQRTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDP----------GKK 70
           P+  R++ V+VAAT   +GIGK+G LPWRL  D+ +FK  T+  +             K 
Sbjct: 10  PSTSRSFVVIVAATAGSLGIGKNGALPWRLAADMAYFKRCTSTPTTSSGTTTATTTTDKI 69

Query: 71  NAIVMGRKTWESIPLKYRPLPGRLNVVLTR--SGSFDIGTAENVVICGSIXXXXXXXXXX 128
           NA++MGRKTW+SIP ++RPL GR NVVL+R  +    +   ++V++ GS+          
Sbjct: 70  NAVIMGRKTWQSIPERFRPLAGRRNVVLSRNPAARDTLRLPKDVLLAGSL--TEALDLLS 127

Query: 129 PYCLS-IEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASI-----ECDTFMPPVDSTKYQ 182
           P   S ++KVFVIGGG ++ E + +  CE +  T +         +CDT  P +D   ++
Sbjct: 128 PAAASEVDKVFVIGGGSVYAEAVASELCEKVLLTSVTPPADGRFDDCDTHFPALDPDTFK 187

Query: 183 LWYSSFPKVENDIRYSFATYVRVQSS 208
           L      + E  +  SF  Y  V  S
Sbjct: 188 LVKKGEAQEEKGVELSFDEYESVNHS 213


>G4YD93_9PHYC (tr|G4YD93) Thymidylate synthase OS=Emiliania huxleyi virus 208
           GN=ERVG_00236 PE=3 SV=1
          Length = 480

 Score =  412 bits (1060), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 224/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++T +TS P  +N ++MG KTW+S+  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTASTSMPICENVVIMGAKTWQSMG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDTCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T      N+  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYNATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNIPKTIFDVTSDDIILNDYKCHPK 473


>G4YBY6_9PHYC (tr|G4YBY6) Thymidylate synthase OS=Emiliania huxleyi virus 207
           GN=EQVG_00246 PE=3 SV=1
          Length = 480

 Score =  412 bits (1060), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 224/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++T +TS P  +N ++MG KTW+S+  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTASTSMPICENVVIMGAKTWQSMG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDTCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T      N+  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYNATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNIPKTIFDVTSDDIILNDYKCHPK 473


>G3GPM8_9PHYC (tr|G3GPM8) Thymidylate synthase OS=Emiliania huxleyi virus 203
           GN=ELVG_00358 PE=3 SV=1
          Length = 480

 Score =  412 bits (1060), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 224/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++T +TS P  +N ++MG KTW+S+  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTASTSMPICENVVIMGAKTWQSMG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDTCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T      N+  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYNATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNIPKTIFDVTSDDIILNDYKCHPK 473


>G9E3L7_9PHYC (tr|G9E3L7) Thymidylate synthase OS=Emiliania huxleyi virus 201
           GN=EPVG_00111 PE=3 SV=1
          Length = 480

 Score =  412 bits (1059), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 224/507 (44%), Positives = 293/507 (57%), Gaps = 53/507 (10%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + K+PW    D+  F+++T +TS P  +N ++MG KTW+S+  
Sbjct: 8   IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTASTSMPICENVVIMGAKTWQSMG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             + LP R N+V++R+           NV I  SI               IE ++VIGG 
Sbjct: 67  --KRLPNRYNIVISRNKDARRVYNIPNNVGISSSIELAISELKTVS---DIETIYVIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 197
            I+++V++    + IH T +       A   CDTF               FP   ND+  
Sbjct: 122 YIYKDVIDLKIVDKIHMTFVSNQHDPGAFDTCDTF---------------FPLTVNDLES 166

Query: 198 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 257
           +F   ++ ++S     +  T      N+  +                 HEEY YL+LI +
Sbjct: 167 NF---IKSKTSYVTKEAHLTCSYHTYNATVI-----------------HEEYQYLQLISK 206

Query: 258 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAK 317
           ++              +S FG  MRFNL   FPLLTTK+ +W+G+VEELLWFI GSTNA 
Sbjct: 207 VLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNAN 266

Query: 318 VLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYD 377
            L  K + IWDGN SR++LDS+GL + EEGDLGPVYGFQWRHFGA Y  MH  Y  QG D
Sbjct: 267 ELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYYSQGTD 326

Query: 378 QLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADM 437
           QL +VI++IK+NP  RRII+SAWNP  L+ MALPPCH+  QF+V +G LSCQMYQRSAD+
Sbjct: 327 QLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADI 386

Query: 438 GLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTL 497
           GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY NH+  L+ QL   P  FPT+
Sbjct: 387 GLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTI 446

Query: 498 KINSEKKDIDSFVAADFKLVGYNPHQK 524
            IN+  K I    + D  L  Y  H K
Sbjct: 447 HINNIPKTIFDVTSDDIILNDYKCHPK 473


>E0DA52_NEOCA (tr|E0DA52) Dihydrofolate reductase OS=Neospora caninum GN=DHFR
           PE=2 SV=1
          Length = 612

 Score =  411 bits (1057), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 236/606 (38%), Positives = 322/606 (53%), Gaps = 106/606 (17%)

Query: 24  LQRTYQVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDPGKK------------ 70
           +Q+   ++ A T   GIG +  LPW  L TD K F  +T  T+D   +            
Sbjct: 1   MQKPVSLIAAMTPRRGIGVNNGLPWPHLATDFKHFSRVTKTTADEVSRLNAWLPKKIAKT 60

Query: 71  ---------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAEN---- 111
                          NA+VMGRKTWES+PLK+RPL  RLN+V++ S   +   AE     
Sbjct: 61  GDSGLPSPAFGVNRFNAVVMGRKTWESLPLKFRPLVDRLNIVVSSSLKEEDIAAEKPLVE 120

Query: 112 ----VVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASI 167
               V +C S+           Y  S+++++V+GG  ++ E L+      ++ T +    
Sbjct: 121 GQQRVRVCDSLPAALRLVDEE-YRESVDQIYVVGGAGLYEEALSLGVVSHLYITRVARDF 179

Query: 168 ECDTFMP--PVDS-----------------------------------TKYQLWYSSFPK 190
            CD F P  P DS                                     Y+  + S   
Sbjct: 180 PCDVFFPAFPGDSILSNKQAASASQPSAAAEPVFVPFCPQLGREKSNEASYRPIFISKTY 239

Query: 191 VENDIRYSFATYVRVQSSAAESLSQN------------TDPLFDNNSDSLKFEVQNFDFL 238
            +N + Y F    + + + A S +++            T P     S S     Q   ++
Sbjct: 240 SDNGVPYDFVVLEKGRKADACSATESCELRGPWTSTGETSPETRLPSSSASAVAQVLAWM 299

Query: 239 PEMILQRHEEYMYLR-----------------LIQEIISEXXXXXXXXXXXXLSKFGCQM 281
            +   ++ E+   +R                 LI +II+             +SKFGC M
Sbjct: 300 ADEDRKKCEKKEIIRAVPHVHFRGHEEFQYLDLIADIINNGATMDDRTGVGVISKFGCTM 359

Query: 282 RFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGL 341
           RF+L ++FPLLTTK+VFW+GV+EELLWFI G TNA  L EKG+ IWD N +RE+LDS  L
Sbjct: 360 RFSLDKAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNL 419

Query: 342 TEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWN 401
           + RE GD+GP YGFQWRHFGA Y DMH DY+GQG DQL  VIN ++ NP DRR++++AWN
Sbjct: 420 SHREVGDIGPGYGFQWRHFGATYKDMHTDYTGQGVDQLKKVINMLRTNPTDRRMLMTAWN 479

Query: 402 PVDLKLMALPPCHMFAQFFVANG-ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCE 460
           P  L  MALPPCH+  QF+V N  +LSC MYQRS D+GLGVPFNIASY+LLT M+AHVC 
Sbjct: 480 PAALDEMALPPCHLLCQFYVENDRDLSCVMYQRSCDVGLGVPFNIASYSLLTLMVAHVCN 539

Query: 461 LVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKI-NSEK-KDIDSFVAADFKLVG 518
           L P +F+H +G+ HVY NHV  L+EQL   P+PFP + I N E+ ++ID F A DF++VG
Sbjct: 540 LKPKEFIHFMGNTHVYSNHVEALKEQLRREPRPFPIVNILNKERIQEIDDFTAEDFEVVG 599

Query: 519 YNPHQK 524
           Y PH +
Sbjct: 600 YVPHGR 605


>G8DFJ0_9PHYC (tr|G8DFJ0) Thymidylate synthase OS=Emiliania huxleyi virus 202
           GN=EXVG_00185 PE=3 SV=1
          Length = 480

 Score =  411 bits (1057), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 226/510 (44%), Positives = 290/510 (56%), Gaps = 59/510 (11%)

Query: 30  VVVAATK----DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 85
           +VVA  K     + IG + ++PW    D+  F+++TT+T  P  +N ++MG KTW+SI  
Sbjct: 8   IVVAGAKCSDGRIAIGVNNRIPWNSKADMHNFRQLTTSTKLPICENVVIMGAKTWQSIG- 66

Query: 86  KYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 143
             R LP R N+V++R+           +V I  SI               +E +++IGG 
Sbjct: 67  --RRLPNRYNIVISRNKDARKVYNLPHDVGISSSIESAIDQLKTVS---DVETIYIIGGS 121

Query: 144 QIFREVLNAPGCEAIHFTEIH------ASIECDTFMP-PVDS--TKYQLWYSSFPKVEND 194
            I++  L+      IH T +       A    DTF P  VD   + +    SS+   EN 
Sbjct: 122 YIYKNALDLGIVSKIHMTFVSDARTPSAFDNSDTFFPLTVDELESNFIKSRSSYITKENH 181

Query: 195 IRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRL 254
           I  S+ TY              T  +                         HEEY YL+L
Sbjct: 182 ITCSYHTY--------------TGSVI------------------------HEEYQYLKL 203

Query: 255 IQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGST 314
           I +++              +S FG  MRF+L   FPLLTTK+ +W+G+VEELLWFI GST
Sbjct: 204 ISKVLEHGEYRHDRTGTGTVSLFGETMRFDLSTHFPLLTTKRTYWKGIVEELLWFIRGST 263

Query: 315 NAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQ 374
           NA  L  K + IWDGN SRE+L+SIGL + EEGDLGPVYGFQWRHFGA Y  MH  Y  Q
Sbjct: 264 NANELAAKNVKIWDGNGSREFLNSIGLNDNEEGDLGPVYGFQWRHFGAEYKTMHDSYDAQ 323

Query: 375 GYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRS 434
           G DQL DVI++IK+NP  RRII+SAWNP  LK MALPPCH+  QF+V +G+LSCQMYQRS
Sbjct: 324 GIDQLQDVIDQIKNNPTSRRIIMSAWNPSALKKMALPPCHLMCQFYVHDGKLSCQMYQRS 383

Query: 435 ADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPF 494
           AD+GLGVPFNIASYALLTC+IAH   L PG+F+HVIGDAHVY +H+  L+ QL   P  F
Sbjct: 384 ADIGLGVPFNIASYALLTCLIAHFTNLTPGEFIHVIGDAHVYTDHIDALKIQLTRKPYNF 443

Query: 495 PTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PT+ IN+  K I    + D  L  Y  H K
Sbjct: 444 PTITINNAPKTIFDVSSDDIVLTNYQCHSK 473


>D3JLA7_TRYCR (tr|D3JLA7) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 462

 Score =  410 bits (1055), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 221/495 (44%), Positives = 283/495 (57%), Gaps = 65/495 (13%)

Query: 39  GIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKTWESIPLKYRPLPG 92
           GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKTW+SIP K+RPLPG
Sbjct: 3   GIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPG 62

Query: 93  RLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFV 139
           RLNVVL+ + +              ++     V + G +           Y  SIE V+ 
Sbjct: 63  RLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLASPNYTPSIETVYC 122

Query: 140 IGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIR 196
           IGGG ++ E L  P     +AI+ T I AS                              
Sbjct: 123 IGGGSVYAEALRPPCVHLLQAIYRTTIRAS-----------------------------E 153

Query: 197 YSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEY 249
            S + + RV  S  E+ +         ++ L   N +  K+      +  ++I +  EE 
Sbjct: 154 SSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------YFEKLIPRNREEE 207

Query: 250 MYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLW 308
            YL L+  II E            LS FG QMRF+LR +  PLLTTK+VFWRGV EELLW
Sbjct: 208 QYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLW 267

Query: 309 FISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           F+ G T AK L +KG+HIWD N SR +LDS GLTE EE DLGPVYGFQWRHFGA Y+   
Sbjct: 268 FLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHD 327

Query: 369 KDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSC 428
            +Y GQG DQ+  ++  +K NP+DRR++ +AWNP  L  MALPPCH+ AQF+V+NGELSC
Sbjct: 328 ANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNGELSC 387

Query: 429 QMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLL 488
            +YQRS DMGLGVPFNIASYALLT +IA    L PG+ VH +GDAHVY NHV P  EQL 
Sbjct: 388 MLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLK 447

Query: 489 NLPKPFPTLKINSEK 503
            +P+ FP L    E+
Sbjct: 448 RVPRAFPYLVFRRER 462


>B6AE97_CRYMR (tr|B6AE97) Thymidylate synthase family protein OS=Cryptosporidium
           muris (strain RN66) GN=CMU_010300 PE=3 SV=1
          Length = 549

 Score =  410 bits (1054), Expect = e-112,   Method: Compositional matrix adjust.
 Identities = 224/529 (42%), Positives = 304/529 (57%), Gaps = 36/529 (6%)

Query: 24  LQRTYQVVVAA-TKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG----------KKNA 72
           LQ+   ++VAA TK+ GIGK   LPW +  DLKFF+EIT +T +            K NA
Sbjct: 18  LQKPVIIIVAASTKEKGIGKGNNLPWSIKEDLKFFREITCSTIEQSQDDKENTKIEKVNA 77

Query: 73  IVMGRKTWESIPLKYRPLPGRLNVVLTRS-GSFDIGTAENVVICGSIXXXXXXXXXXPYC 131
           I++GRKTW+S  +K  PL  R  +VL+R+    D      V I  S+             
Sbjct: 78  IILGRKTWDS--MKRIPLKNRKVIVLSRTLQRCDNKNDSGVSIVKSLDEAINLCNND--- 132

Query: 132 LSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASI-ECDTFMPPVDSTKYQLWYSSFPK 190
           +SI K+ + GG  I+RE +     E I+ T +  S  E DT+ P +  +   +  S    
Sbjct: 133 ISIHKIVICGGESIYRECIEKNIVETIYLTRVSTSKKEFDTYFPNIPESFVPILMSQ-TF 191

Query: 191 VENDIRYSFATY-----------VRVQSSAAESL---SQNTDPLFDNNSDSLKFEVQNFD 236
             NDI Y F  Y           +R  S  +E +       D +F     SL+ +V   D
Sbjct: 192 CCNDISYDFMIYENEILKPIKRNIRNTSCESEVIIPFENVLDKIFGERKISLRNKVPKDD 251

Query: 237 FL--PEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTT 294
            +  P +I++ H E+ YL ++  ++               S FG  MRF+LR SFPLLTT
Sbjct: 252 IISYPSIIIRDHPEFQYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFPLLTT 311

Query: 295 KKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYG 354
           K V  R + EEL+WFI G TN   L +K + IW GN S+EYL+ +GL  REE DLGP+YG
Sbjct: 312 KNVALRIIFEELMWFIKGDTNGNHLLDKKVFIWAGNGSKEYLNKVGLGYREENDLGPIYG 371

Query: 355 FQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCH 414
           FQWRHF A Y  MH +Y+GQG DQL ++I  +K NP DRR ILSAWNP  +K MALPPCH
Sbjct: 372 FQWRHFNAEYKTMHDNYNGQGVDQLANLIESLKKNPYDRRHILSAWNPSAVKYMALPPCH 431

Query: 415 MFAQFFV-ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDA 473
           + +QF+V  N  LSC +YQRS D+GLG PFNIASY+LL  MIAH+C   PG+F+H IGD 
Sbjct: 432 ILSQFYVDNNNRLSCSLYQRSCDLGLGCPFNIASYSLLCVMIAHICGYEPGEFIHFIGDV 491

Query: 474 HVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           H+Y NHV  L++Q+  LP+PFP L++  +   ++ F+  D +++GY PH
Sbjct: 492 HIYENHVEQLKQQIKRLPRPFPQLRLKRKVDKVEDFIWEDIEIIGYYPH 540


>F2ULJ1_SALS5 (tr|F2ULJ1) Thymidylate synthase OS=Salpingoeca sp. (strain ATCC
           50818) GN=PTSG_09625 PE=3 SV=1
          Length = 293

 Score =  407 bits (1047), Expect = e-111,   Method: Compositional matrix adjust.
 Identities = 187/283 (66%), Positives = 218/283 (77%)

Query: 242 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRG 301
           + Q H+E+ YLRL+Q I+              +S FG QMRF+LR  FPLLTTK+VFWRG
Sbjct: 4   VEQNHDEHEYLRLVQRILDTGKTRSDRTGTGTISLFGAQMRFSLREGFPLLTTKRVFWRG 63

Query: 302 VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFG 361
           V+EELLWFI+G TNA  L EK +HIWD N S+E+L+  GL  REEGDLGPVYGFQWRHFG
Sbjct: 64  VLEELLWFIAGDTNANHLAEKKVHIWDANGSKEFLEQRGLGHREEGDLGPVYGFQWRHFG 123

Query: 362 ARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFV 421
           A+Y+DMH DY G+G DQ+ +VI +IK NP+ RRII+SAWNPVDL  MALPPCH+ AQF+V
Sbjct: 124 AQYTDMHADYQGKGVDQIANVIEQIKTNPDSRRIIMSAWNPVDLPHMALPPCHVLAQFYV 183

Query: 422 ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVR 481
            +GELSCQ+YQRSADMGLGVPFNIASY+LLT MIAHVC L PGDFVH IGDAHVY NHV 
Sbjct: 184 QDGELSCQLYQRSADMGLGVPFNIASYSLLTVMIAHVCGLRPGDFVHTIGDAHVYSNHVD 243

Query: 482 PLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
            L+EQL   P+PFPTL I  +   ID F A DF+LVGY PH K
Sbjct: 244 ALKEQLTREPRPFPTLNIKRDVTSIDDFKAEDFELVGYKPHGK 286


>J4C4E3_THEOR (tr|J4C4E3) Bifunctional dihydrofolate reductase/thymidilate
           synthase OS=Theileria orientalis strain Shintoku
           GN=TOT_040000412 PE=3 SV=1
          Length = 512

 Score =  406 bits (1043), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 213/502 (42%), Positives = 297/502 (59%), Gaps = 18/502 (3%)

Query: 29  QVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDPGKK-------NAIVMGRKTW 80
           +++   T D GIG    LPW  +  D  +   +TT   DP  K       N +V+GRKT+
Sbjct: 12  KILAGITPDNGIGNTNGLPWPHIKRDFLYMFRLTTYV-DPSVKQNNSEIQNVVVIGRKTY 70

Query: 81  ESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVI 140
           +S+P    P   R++VV++R+    +       +  S+             L+  K+F++
Sbjct: 71  DSLPPNTFPFKNRISVVISRT----LSEVPGGFVFDSVPKALMYIKDN---LNYYKIFIL 123

Query: 141 GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFA 200
           GG  I+ EV+N P  + ++ T ++    CD F P +    Y +   S      D  Y F 
Sbjct: 124 GGSFIYNEVINMPVLDTLYITRVNKKYPCDVFFPKI-PEDYVITGISKTFTNGDTTYDFV 182

Query: 201 TYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIIS 260
           TY R      E   +    L     +    +   +   P + ++  +E  YL ++ +I++
Sbjct: 183 TYERKDQLREEPDHRTFHELL-LTGEKFANKPPLYKACPNLKVRYSQELQYLDILADILN 241

Query: 261 EXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQ 320
                         +KFG QMRF+L  SFPLLTTKKVF RG++EEL+WFI GSTN   L 
Sbjct: 242 NGVKKTNRTGVDCFAKFGYQMRFDLSESFPLLTTKKVFLRGIIEELIWFIRGSTNGNDLL 301

Query: 321 EKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLL 380
           +K + IW+ N +R +LD++G  +REE DLGPVYGFQWRHFGA+Y DMH DY+GQG DQL 
Sbjct: 302 KKNVKIWELNGARGFLDALGFYDREEHDLGPVYGFQWRHFGAKYVDMHTDYNGQGIDQLS 361

Query: 381 DVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLG 440
            +I+KIK+ PNDRR+I+ +WN  DL  MALPPCH+  QFFVA+G+LSC M+QRS DMGLG
Sbjct: 362 ILIDKIKNKPNDRRLIVCSWNVADLSKMALPPCHLLFQFFVADGKLSCMMHQRSCDMGLG 421

Query: 441 VPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKIN 500
           VPFNIASY+LLT MIA +C+L PG+FVH +GDAH+Y NHV  ++EQ+  +P PFP+LK+N
Sbjct: 422 VPFNIASYSLLTYMIAQICDLEPGEFVHNLGDAHIYCNHVDAVKEQISRVPYPFPSLKLN 481

Query: 501 SEKKDIDSFVAADFKLVGYNPH 522
            E K I+ F   D K+  Y  H
Sbjct: 482 KEIKRIEDFTLEDIKVENYISH 503


>Q7RGH7_PLAYO (tr|Q7RGH7) Thymidylate synthase, putative OS=Plasmodium yoelii
           yoelii GN=PY04370 PE=3 SV=1
          Length = 588

 Score =  406 bits (1043), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 216/546 (39%), Positives = 302/546 (55%), Gaps = 60/546 (10%)

Query: 39  GIGKDGKLPWRL-FTDLKFFKEITTATSDP-------------GKKN------------- 71
           G+G  G LPW+    D+ +F  +T+  ++              GK N             
Sbjct: 36  GLGNAGMLPWKYNLVDMNYFSSVTSYVNENNYIRLQWKRDKYMGKNNLKNNAELNNGELN 95

Query: 72  -----AIVMGRKTWESIPLKYRPLPGRLNVVLTRS-GSFDIGTAENVVI-CGSIXXXXXX 124
                 +VMG+++W+SIP K++PL  R+N++L+R+    DI   +N     G++      
Sbjct: 96  NNLQNVVVMGKRSWDSIPPKFKPLQNRINIILSRTLKKEDIANEDNKNNENGTVMIIKSV 155

Query: 125 XXXXPYCLSIE--KVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQ 182
               P   +I+  K F+IGG  +++E L+    + I+FT I+ S  CD   P ++   ++
Sbjct: 156 DDLFPILKAIKYYKCFIIGGSYVYKEFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFK 215

Query: 183 LWYSSFPKVENDIRYSFATYVR----------VQSSAAESLSQNTDPLFDNNSDSLKF-- 230
           +   S     N+    F  Y +          + +     L    +  FD+  D   F  
Sbjct: 216 ISSISDVYNSNNTTLDFIIYSKKTEKINSNKEISNDIFLGLCDEQNKNFDDEDDYTYFSF 275

Query: 231 ------------EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFG 278
                        V NF     +  + H EY YL +I +II              LSKFG
Sbjct: 276 NKNKENIKKNSEHVHNFKIYNSIKYKNHPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFG 335

Query: 279 CQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDS 338
             M+FNL + FPLLTTKK+F RG++EELLWFI G TN   L EK + IW+ N +RE+LD+
Sbjct: 336 YMMKFNLNQYFPLLTTKKLFVRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDN 395

Query: 339 IGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILS 398
             L  RE  DLGP+YGFQWRHFGA Y+DMH +Y  +G DQL ++IN IK++P  RRIIL 
Sbjct: 396 RKLFHREVNDLGPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNIINLIKNDPTCRRIILC 455

Query: 399 AWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHV 458
           AWN  DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA V
Sbjct: 456 AWNVKDLDKMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQV 515

Query: 459 CELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVG 518
           C L P +F+HV+G+AHVY+NH+  L+ QL   P PFPTLK+N + K+I+ F  +DF +  
Sbjct: 516 CNLQPAEFIHVLGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQN 575

Query: 519 YNPHQK 524
           Y  H K
Sbjct: 576 YVHHDK 581


>H2YU26_CIOSA (tr|H2YU26) Uncharacterized protein OS=Ciona savignyi GN=Csa.11299
           PE=3 SV=1
          Length = 313

 Score =  405 bits (1042), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 188/281 (66%), Positives = 217/281 (77%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVV 303
           +RH+E  YL LI++I+               S FGCQMRFNLR SFPLLTTK+VFWRGV 
Sbjct: 26  KRHDENCYLDLIRQILDSGNLKGDRTGTGTKSIFGCQMRFNLRTSFPLLTTKRVFWRGVA 85

Query: 304 EELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGAR 363
           EELLWFI GSTNAK L +K +HIWD N SR++LD +GLT+R+E DLGPVYGFQWRHFGA+
Sbjct: 86  EELLWFIRGSTNAKELADKKVHIWDKNGSRKFLDGLGLTDRDEFDLGPVYGFQWRHFGAQ 145

Query: 364 YSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN 423
           Y DMH DY+ QG DQL  VI+ I++NP+DRRII+ AWNPVD+ LMALPPCH   QF+V N
Sbjct: 146 YKDMHTDYTDQGVDQLRKVIDTIRNNPDDRRIIMCAWNPVDIPLMALPPCHALCQFYVCN 205

Query: 424 GELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPL 483
           GELSCQ+YQRSADMGLGVPFNIASY+LLT MIAHV  L PGDFVH +GDAHVY NH+ PL
Sbjct: 206 GELSCQLYQRSADMGLGVPFNIASYSLLTYMIAHVTGLKPGDFVHTLGDAHVYLNHIEPL 265

Query: 484 QEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           +EQL   P+PFPTLK   E  DID F   DF L GY PH+K
Sbjct: 266 EEQLSREPRPFPTLKFAREIHDIDDFTMDDFILEGYKPHRK 306


>Q95US9_PLAGA (tr|Q95US9) Dihydrofolate reductase/thymidylate synthase
           OS=Plasmodium gallinaceum GN=DHFR/TS PE=3 SV=1
          Length = 589

 Score =  405 bits (1042), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 216/550 (39%), Positives = 300/550 (54%), Gaps = 69/550 (12%)

Query: 39  GIGKDGKLPWRLF-TDLKFFKEITTATSDPGKK--------------------------- 70
           GIG  G LPW+    D+K+F  +TT  ++   K                           
Sbjct: 38  GIGNKGVLPWKSNPLDMKYFTTVTTYVNESKYKKLKYKREKYLEKTKDTKCLESIIQLSN 97

Query: 71  ---NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXX 127
              N +VMGR +WESIP ++RPL  R+NVVL+RS   +    + ++I             
Sbjct: 98  NLQNVVVMGRTSWESIPERFRPLVNRINVVLSRSLKKEDIKGDAILINNVDDLLLLLRKI 157

Query: 128 XPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSS 187
             Y     K F+IGG  ++ E L     + I+FT I+++ ECD F P +  T++++   S
Sbjct: 158 NYY-----KCFIIGGSVVYNEFLKRNLIKKIYFTRINSTYECDVFFPEIKETEFEIMSLS 212

Query: 188 FPKVENDIRYSFATYVRVQ-----------SSAAESLSQNTDPLF----------DNNSD 226
                N     F  Y R +           +  A+  SQ++   +          D++ D
Sbjct: 213 DVYSNNGATLDFVIYKRKKEILNNENPIENNKEADICSQDSPNNYFTGEDVYKNMDDDDD 272

Query: 227 SLKFEVQN------------FDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXL 274
            + F   N            F     +  + H EY YL +I ++I              +
Sbjct: 273 YVYFNFNNTKEKKNSEISDDFKIYNSLKYKYHPEYQYLNIIYDVIMNGNKQGDRTGVGVV 332

Query: 275 SKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASRE 334
           SKFG  M+FNL + FPLLTTKK+F RG++EELLWFI G TN   L  K + IW+ N +RE
Sbjct: 333 SKFGYMMKFNLNQYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTRE 392

Query: 335 YLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRR 394
           +LD   L +RE  DLGP+YGFQWRHFGA Y++MH +Y  +G DQL ++IN IK+ P  RR
Sbjct: 393 FLDKRKLFDREVNDLGPIYGFQWRHFGAEYTNMHDNYENKGVDQLKNIINLIKNEPTSRR 452

Query: 395 IILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCM 454
           IIL AWN  DL  MALPPCH+  QF+V + +LSC MYQRS D+GLGVPFNIASY++ T M
Sbjct: 453 IILCAWNVKDLDKMALPPCHILCQFYVFDNKLSCIMYQRSCDLGLGVPFNIASYSIFTYM 512

Query: 455 IAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADF 514
           IA VC L P  F+H++G+AHVY+NH+  L++QL  +P PFPTLK+N + K+I+ F  +DF
Sbjct: 513 IAQVCNLQPAQFIHILGNAHVYNNHIDSLKKQLNRIPYPFPTLKLNPDIKNIEDFKVSDF 572

Query: 515 KLVGYNPHQK 524
            +  Y  H K
Sbjct: 573 TIENYVHHDK 582


>Q4U9G5_THEAN (tr|Q4U9G5) Bifunctional dihydrofolate reductase/thymidilate
           synthase, putative OS=Theileria annulata GN=TA08775 PE=3
           SV=1
          Length = 523

 Score =  405 bits (1040), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 216/511 (42%), Positives = 302/511 (59%), Gaps = 25/511 (4%)

Query: 29  QVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITT------ATSDPGKKNAIVMGRKTWE 81
           +++VA T + GIG    LPW  +  D  F    TT          PG +N I++GR T++
Sbjct: 12  KILVAITPENGIGIKNGLPWPHIKRDFLFMFRATTYVDPEFKEKHPGAENVIIIGRNTYD 71

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXP-YCLSIEKVFVI 140
           S+P    PL  R+N+V++R+ +   G      I  +I            + + I  V V+
Sbjct: 72  SLPESVFPLKNRINIVISRNLTEVPGGLVFSSIPSAIRHVTENLNYYKIFIMGIFNVVVL 131

Query: 141 ---GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDS----TKYQLWYSSFPKVEN 193
              GG  ++REVLNA   + ++ T ++ + EC+ F P +      T     +SS      
Sbjct: 132 KYLGGSHVYREVLNAKIVDKMYVTRVNKNYECEVFFPKIPDDFVITGISKTFSS-----E 186

Query: 194 DIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQN--FDFLPEMILQRHEEYMY 251
           D  Y F  Y R          +  + +        KF V+       P + ++  +E  Y
Sbjct: 187 DTSYDFVLYERKDLIEEMKEKKTFEQMLLTGE---KFAVKEPLVKACPRLKVRYSQELQY 243

Query: 252 LRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFIS 311
           L ++ +I++             ++KFG QMRF+L +SFPLLTTKKVF RG++EEL+WFI 
Sbjct: 244 LEILADILNNGYHKKNRTGVDCIAKFGYQMRFDLSQSFPLLTTKKVFLRGIIEELIWFIR 303

Query: 312 GSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDY 371
           GSTN   L +K + IW+ N +R +LD++G  +REE DLGPVYGFQWRHFGA+Y DMH DY
Sbjct: 304 GSTNGNELLKKNVRIWELNGARSFLDNLGFYDREEQDLGPVYGFQWRHFGAKYIDMHADY 363

Query: 372 SGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMY 431
           + QG DQL  VI +IK+NP++RR+I+ +WN  DL  MALPPCH+  QFFVA+G LSC M+
Sbjct: 364 TDQGIDQLSLVIERIKNNPDNRRLIVCSWNVADLSKMALPPCHLLFQFFVADGTLSCMMH 423

Query: 432 QRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLP 491
           QRS DMGLGVPFNIASY+LLT MIAH+C L PG+FVH +GDAH+Y+NH+  ++EQ+  +P
Sbjct: 424 QRSCDMGLGVPFNIASYSLLTYMIAHICGLKPGEFVHNLGDAHIYNNHIDAIKEQISRVP 483

Query: 492 KPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            PFPTLK+N E   I+ F   D K+  Y  H
Sbjct: 484 YPFPTLKLNKEITRIEDFTIDDIKVENYRCH 514


>D3VZW1_9APIC (tr|D3VZW1) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium billbrayi GN=DHFR-TS PE=3 SV=1
          Length = 608

 Score =  404 bits (1039), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 220/568 (38%), Positives = 303/568 (53%), Gaps = 87/568 (15%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 39  GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETLNNVMDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXP 129
            N +VMGR +WESIP K++PL  R+NV+L+R+   +    E+V I   +           
Sbjct: 99  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKE-DIDEDVYIINKVEDLIVLLGKLN 157

Query: 130 YCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP 189
           Y     K F+IGG  +++E L     + I+FT I++S ECD F P ++  +YQ+   S  
Sbjct: 158 Y----YKCFIIGGSVVYKEFLEKKLIKKIYFTRINSSYECDVFFPEINENEYQIISVSDV 213

Query: 190 KVENDIRYSFATY------VRVQSSAAESLSQNTDPLFDN----------------NSDS 227
              N+    F  Y      V  +    +   +N D    N                N D 
Sbjct: 214 YTSNNTTLDFVIYKKKNNQVLNEKDCIKGEEENNDMSLKNDDKVTCHMKKLTEFYKNVDK 273

Query: 228 LKFEVQN-------------------------------FDFLPEMILQRHEEYMYLRLIQ 256
            K   +N                               F     +  + H EY YL +I 
Sbjct: 274 YKINYENDDDDEEEDDFVYFNFNKEKEEKNKNCVHPNDFKIYNSLKHKCHPEYQYLNIIY 333

Query: 257 EIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNA 316
           +II              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G TN 
Sbjct: 334 DIIMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNG 393

Query: 317 KVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGY 376
             L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++MH +Y  +G 
Sbjct: 394 NTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYENKGV 453

Query: 377 DQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSAD 436
           DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQRS D
Sbjct: 454 DQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCD 513

Query: 437 MGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPT 496
           +GLGVPFNIASY++ T MIA VC L P +F+HV+G+AHVY+NH+  L+ QL  +P PFPT
Sbjct: 514 LGLGVPFNIASYSIFTHMIAQVCNLQPAEFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPT 573

Query: 497 LKINSEKKDIDSFVAADFKLVGYNPHQK 524
           LK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 574 LKLNPDIKNIEDFTISDFTIQNYVHHEK 601


>Q4XXZ2_PLACH (tr|Q4XXZ2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Plasmodium chabaudi
           GN=PC000873.02.0 PE=3 SV=1
          Length = 498

 Score =  403 bits (1036), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 207/484 (42%), Positives = 281/484 (58%), Gaps = 33/484 (6%)

Query: 70  KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAE--NVVICGSIXXXXXXXXX 127
           +N +VMG+ +WESIP K++PL  R+N++L+R+   +    E  NV+I  S+         
Sbjct: 12  QNIVVMGKASWESIPSKFKPLQNRINIILSRTLKKEDLAKEYNNVIIINSVDDLFPILKS 71

Query: 128 XPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSS 187
             Y     K FVIGG  +++E L+    + I+FT I+ +  CD   P ++   +++   S
Sbjct: 72  IKY----YKCFVIGGASVYKEFLDRNLIKKIYFTRINNAYTCDVLFPDINEDLFKITSIS 127

Query: 188 FPKVENDIRYSFATYVRVQ-------------SSAAESLSQNTDPLFDNNSDSLKF---- 230
                N+    F  Y + +             ++A   +    +  FD+  D   F    
Sbjct: 128 DVYSSNNTTLDFVIYSKTKEIPEEINPNDEIFNNAFLGVCDEKNTNFDDEDDYTYFSFNK 187

Query: 231 ----------EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQ 280
                        +F     +  + H EY YL +I +II              LSKFG  
Sbjct: 188 HKDNIKKNSEHAHHFKIYNSIKYKHHPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFGYM 247

Query: 281 MRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIG 340
           M+FNL   FPLLTTKK+F RG++EELLWFI G TN   L EK + IW+ N +RE+LD+  
Sbjct: 248 MKFNLSEYFPLLTTKKLFVRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDNRK 307

Query: 341 LTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAW 400
           L  RE  DLGP+YGFQWRHFGA Y+DMH DY  +G DQL ++IN IK++P  RRIIL AW
Sbjct: 308 LFHREVNDLGPIYGFQWRHFGAEYTDMHADYKDKGVDQLKNIINLIKNDPTCRRIILCAW 367

Query: 401 NPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCE 460
           N  DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC 
Sbjct: 368 NVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCN 427

Query: 461 LVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYN 520
           L P +F+HV+G+AHVY+NHV  L+ QL   P PFPTLK+N E K+I+ F  +DF +  Y 
Sbjct: 428 LQPAEFIHVLGNAHVYNNHVESLKVQLNRTPYPFPTLKLNPEIKNIEDFTISDFTVQNYV 487

Query: 521 PHQK 524
            H K
Sbjct: 488 HHDK 491


>D3VZW2_9APIC (tr|D3VZW2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Plasmodium billbrayi GN=DHFR-TS
           PE=3 SV=1
          Length = 599

 Score =  403 bits (1035), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 221/571 (38%), Positives = 306/571 (53%), Gaps = 93/571 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 31  GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 90

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 91  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLL- 145

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              + L+  K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 146 ---WKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPAINENEYQIISX 202

Query: 187 SFPKVENDIRYSFATY------VRVQSSAAESLSQNTDPLFDN----------------N 224
           S     N+    F  Y      V  +    +   +N D    N                N
Sbjct: 203 SDVYTSNNTTLDFVIYKKKNNQVLNEKDCIKGEEENNDMSLKNDDKVTCHMKKLTEFYKN 262

Query: 225 SDSLKFEVQN-------------------------------FDFLPEMILQRHEEYMYLR 253
            D  K   +N                               F     +  + H EY YL 
Sbjct: 263 VDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNCVHPNDFKIYNSLKHKCHPEYQYLN 322

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGS 313
           +I +II              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G 
Sbjct: 323 IIYDIIMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 382

Query: 314 TNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSG 373
           TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++MH +Y  
Sbjct: 383 TNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYEN 442

Query: 374 QGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQR 433
           +G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQR
Sbjct: 443 KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQR 502

Query: 434 SADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKP 493
           S D+GLGVPFNIASY++ T MIA VC L P +F+HV+G+AHVY+NH+  L+ QL  +P P
Sbjct: 503 SCDLGLGVPFNIASYSIFTHMIAQVCNLQPAEFIHVLGNAHVYNNHIDSLKIQLNRIPYP 562

Query: 494 FPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           FPTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 563 FPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 593


>K1QYM1_CRAGI (tr|K1QYM1) Thymidylate synthase OS=Crassostrea gigas
           GN=CGI_10021031 PE=3 SV=1
          Length = 306

 Score =  403 bits (1035), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 186/280 (66%), Positives = 213/280 (76%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           +H+E +YL  +Q +I              LS FG QMR+NLR SFPLLTTK+VFWRGV E
Sbjct: 20  QHDEELYLEAVQRVIDHGRRKSNRTGIDTLSTFGMQMRYNLRDSFPLLTTKRVFWRGVAE 79

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWF+ G TN K L EKG+HIWD N SRE+LD++GL  REEGDLGPVYGFQWRHFGA Y
Sbjct: 80  ELLWFVQGCTNGKKLSEKGVHIWDANGSREFLDNLGLNHREEGDLGPVYGFQWRHFGAEY 139

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
            DMH DYSGQG DQL + I KIK+NP+DRRII+SAWNP DL  MALPPCH F QF+V +G
Sbjct: 140 KDMHTDYSGQGVDQLKNAIEKIKNNPDDRRIIISAWNPCDLDKMALPPCHAFIQFYVCDG 199

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELS Q+YQRS D+GLGVPFNIASY+LLT MIAHV  L PGDFVH +GDAHVY NH+ PL+
Sbjct: 200 ELSSQLYQRSGDIGLGVPFNIASYSLLTYMIAHVTGLKPGDFVHTLGDAHVYVNHIEPLK 259

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
            QL   P+PFP L I  E KDID F   DF++VGYNPH K
Sbjct: 260 IQLQRKPRPFPKLLIKREVKDIDDFKFEDFEIVGYNPHPK 299


>D9N170_PLAFA (tr|D9N170) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium falciparum GN=DHFR-TS PE=1 SV=1
          Length = 608

 Score =  402 bits (1034), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 219/571 (38%), Positives = 306/571 (53%), Gaps = 93/571 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F+ +TT  ++                         P  K  
Sbjct: 39  GLGNKGVLPWKCISLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR  WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 99  QNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F++GG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 155 KLNY----YKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210

Query: 187 SFPKVENDIRYSFATYVRV------QSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y +       + +  +   +N D PL               F  N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 270

Query: 225 SDSLKFEVQN-------------------------------FDFLPEMILQRHEEYMYLR 253
            D  K   +N                               F     +  + H EY YL 
Sbjct: 271 VDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLN 330

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGS 313
           +I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G 
Sbjct: 331 IIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 390

Query: 314 TNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSG 373
           TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  
Sbjct: 391 TNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN 450

Query: 374 QGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQR 433
           +G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQR
Sbjct: 451 KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQR 510

Query: 434 SADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKP 493
           S D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P P
Sbjct: 511 SCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYP 570

Query: 494 FPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           FPTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 571 FPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601


>C3S7P8_PLAFA (tr|C3S7P8) Dihydrofolate reductase/thymidylate synthase
           OS=Plasmodium falciparum GN=dhfr-ts PE=3 SV=1
          Length = 608

 Score =  402 bits (1033), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 220/571 (38%), Positives = 306/571 (53%), Gaps = 93/571 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F+ +TT  ++                         P  K  
Sbjct: 39  GLGNKGVLPWKCNSLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR  WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 99  QNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 155 KLNY----YKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210

Query: 187 SFPKVENDIRYSFATYVRV------QSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y +       + +  +   +N D PL               F  N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 270

Query: 225 SDSLKFEVQN-------------------------------FDFLPEMILQRHEEYMYLR 253
            D  K   +N                               F     +  + H EY YL 
Sbjct: 271 VDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLN 330

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGS 313
           +I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G 
Sbjct: 331 IIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 390

Query: 314 TNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSG 373
           TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  
Sbjct: 391 TNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN 450

Query: 374 QGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQR 433
           +G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQR
Sbjct: 451 KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQR 510

Query: 434 SADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKP 493
           S D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P P
Sbjct: 511 SCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYP 570

Query: 494 FPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           FPTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 571 FPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601


>Q19N46_PLAVI (tr|Q19N46) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  401 bits (1031), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 227/579 (39%), Positives = 309/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRVEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKCYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>A7UD79_PLAFA (tr|A7UD79) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium falciparum GN=DHFR-TS PE=1 SV=1
          Length = 608

 Score =  401 bits (1031), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 220/571 (38%), Positives = 306/571 (53%), Gaps = 93/571 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 39  GLGNKGVLPWKCNSLDMKYFYAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 99  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 155 KLNY----YKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210

Query: 187 SFPKVENDIRYSFATYVRV------QSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y +       + +  +   +N D PL               F  N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 270

Query: 225 SDSLKFEVQN-------------------------------FDFLPEMILQRHEEYMYLR 253
            D  K   +N                               F     +  + H EY YL 
Sbjct: 271 VDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLN 330

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGS 313
           +I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G 
Sbjct: 331 IIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 390

Query: 314 TNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSG 373
           TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  
Sbjct: 391 TNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN 450

Query: 374 QGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQR 433
           +G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQR
Sbjct: 451 KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQR 510

Query: 434 SADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKP 493
           S D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P P
Sbjct: 511 SCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYP 570

Query: 494 FPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           FPTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 571 FPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601


>Q8I1R6_PLAF7 (tr|Q8I1R6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium falciparum (isolate 3D7)
           GN=DHFR-TS PE=3 SV=1
          Length = 608

 Score =  401 bits (1030), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 220/571 (38%), Positives = 306/571 (53%), Gaps = 93/571 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 39  GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 99  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 155 KLNY----YKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210

Query: 187 SFPKVENDIRYSFATYVRV------QSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y +       + +  +   +N D PL               F  N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 270

Query: 225 SDSLKFEVQN-------------------------------FDFLPEMILQRHEEYMYLR 253
            D  K   +N                               F     +  + H EY YL 
Sbjct: 271 VDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLN 330

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGS 313
           +I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G 
Sbjct: 331 IIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 390

Query: 314 TNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSG 373
           TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  
Sbjct: 391 TNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN 450

Query: 374 QGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQR 433
           +G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQR
Sbjct: 451 KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQR 510

Query: 434 SADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKP 493
           S D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P P
Sbjct: 511 SCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYP 570

Query: 494 FPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           FPTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 571 FPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601


>K7J2X4_NASVI (tr|K7J2X4) Thymidylate synthase OS=Nasonia vitripennis PE=3 SV=1
          Length = 313

 Score =  401 bits (1030), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 186/282 (65%), Positives = 218/282 (77%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           + HEEY YL+LI+ II++               FG QMRF+LR   FPLLTTK V WR V
Sbjct: 25  EDHEEYQYLKLIERIIAKGAVKTDRTGVGTHFIFGTQMRFSLRDGIFPLLTTKNVLWRAV 84

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           VEELLWFI GSTNAK L +KG+ IW+ N+SRE+LDS G T+REEGDLGPVYGFQWRHFGA
Sbjct: 85  VEELLWFIKGSTNAKELADKGVKIWNANSSREFLDSCGFTDREEGDLGPVYGFQWRHFGA 144

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
           +Y +MH DY+GQG DQL DVINKIK+ P+DRRII+ AWNPVD+ +MALPPCH   QF VA
Sbjct: 145 KYVNMHTDYTGQGVDQLQDVINKIKNKPDDRRIIMCAWNPVDIPIMALPPCHALVQFCVA 204

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           +GELSCQ+YQRSADMGLGVPFNIASY+LLTCMIAH+  L PGDFVH +GD HVY NHV  
Sbjct: 205 DGELSCQLYQRSADMGLGVPFNIASYSLLTCMIAHITNLKPGDFVHTMGDCHVYRNHVPA 264

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           L+EQ+   PKPFPTLKI  + ++ID F + DF+L  Y PH K
Sbjct: 265 LKEQIARKPKPFPTLKITRKVENIDDFKSTDFELNNYKPHAK 306


>A7UD81_PLAFA (tr|A7UD81) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium falciparum GN=DHFR-TS PE=1 SV=1
          Length = 608

 Score =  401 bits (1030), Expect = e-109,   Method: Compositional matrix adjust.
 Identities = 220/571 (38%), Positives = 306/571 (53%), Gaps = 93/571 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 39  GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 99  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 155 KLNY----YKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210

Query: 187 SFPKVENDIRYSFATYVRV------QSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y +       + +  +   +N D PL               F  N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 270

Query: 225 SDSLKFEVQN-------------------------------FDFLPEMILQRHEEYMYLR 253
            D  K   +N                               F     +  + H EY YL 
Sbjct: 271 VDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLN 330

Query: 254 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGS 313
           +I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G 
Sbjct: 331 IIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 390

Query: 314 TNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSG 373
           TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  
Sbjct: 391 TNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN 450

Query: 374 QGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQR 433
           +G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQR
Sbjct: 451 KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQR 510

Query: 434 SADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKP 493
           S D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P P
Sbjct: 511 SCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYP 570

Query: 494 FPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           FPTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 571 FPTLKLNPDIKNIEDFTISDFTIQNYVHHEK 601


>E9GKZ0_DAPPU (tr|E9GKZ0) Putative uncharacterized protein OS=Daphnia pulex
           GN=DAPPUDRAFT_304293 PE=3 SV=1
          Length = 292

 Score =  399 bits (1026), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 186/281 (66%), Positives = 221/281 (78%), Gaps = 1/281 (0%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVV 303
           +HEE+ YL LI+ ++               S FG QMRF+LR   FPLLTTK+VFWRG++
Sbjct: 5   QHEEHQYLNLIKNLLQNGNVKGDRTGTGTRSIFGAQMRFSLRSGRFPLLTTKRVFWRGLM 64

Query: 304 EELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGAR 363
           EELLWF+ GSTNA  L+EK IHIWDGN+SRE+LDS+GL +REEGDLGP+YGFQWRHFGA 
Sbjct: 65  EELLWFVRGSTNANELREKDIHIWDGNSSREFLDSLGLKDREEGDLGPIYGFQWRHFGAN 124

Query: 364 YSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN 423
           Y +MH DYS QG DQL ++IN I+ NP+DRR+IL+AWNP  L LMALPPCH  AQF+VAN
Sbjct: 125 YDNMHSDYSCQGVDQLKNLINTIRTNPDDRRMILTAWNPSALPLMALPPCHCLAQFYVAN 184

Query: 424 GELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPL 483
           GELSCQMYQRSADMGLGVPFNIASY+LLTCMIAHV  L PG+F+H +GDAHVY+NH+  L
Sbjct: 185 GELSCQMYQRSADMGLGVPFNIASYSLLTCMIAHVTGLNPGEFIHTLGDAHVYNNHISAL 244

Query: 484 QEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           ++QL   P+PFPTLKI  +  DID F A DF L GY+PH K
Sbjct: 245 EKQLERQPRPFPTLKIIRKVSDIDDFKADDFVLEGYDPHPK 285


>Q19PB8_PLAVI (tr|Q19PB8) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  399 bits (1026), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/579 (39%), Positives = 309/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPERLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGAGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKSVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLENVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>D3VZV8_PLARE (tr|D3VZV8) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Plasmodium reichenowi GN=DHFR-TS
           PE=3 SV=1
          Length = 598

 Score =  399 bits (1026), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 221/570 (38%), Positives = 304/570 (53%), Gaps = 92/570 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 31  GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 90

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 91  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 146

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 147 KLNY----YKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPAINENEYQIISV 202

Query: 187 SFPKVENDIRYSFATY------VRVQSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y      V  +    +   +N D PL               F  N
Sbjct: 203 SDVYTSNNTTLDFIIYQKKDNKVLNEQDCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 262

Query: 225 SDSLKFEVQN------------------------------FDFLPEMILQRHEEYMYLRL 254
            D  K   +N                              F     +  + H EY YL +
Sbjct: 263 VDKYKINYENDDDDEEDDFVYFNFNKEKEEKNKNSVHPNDFQIYNSLKYKYHPEYQYLNI 322

Query: 255 IQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGST 314
           I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G T
Sbjct: 323 IYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGET 382

Query: 315 NAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQ 374
           N   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  +
Sbjct: 383 NGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENK 442

Query: 375 GYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRS 434
           G DQL ++IN IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQRS
Sbjct: 443 GVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRS 502

Query: 435 ADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPF 494
            D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P PF
Sbjct: 503 CDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPF 562

Query: 495 PTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PTLK+N + K+I+ F   DF +  Y  H+K
Sbjct: 563 PTLKLNPDIKNIEDFTILDFTIQNYVHHEK 592


>A8C2U7_PLABR (tr|A8C2U7) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium brasilianum PE=3 SV=1
          Length = 621

 Score =  399 bits (1025), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/601 (37%), Positives = 313/601 (52%), Gaps = 102/601 (16%)

Query: 21  LPNLQRTYQVVVAATKDM-GIGKDGKLPWRLFT-DLKFFKEITTATSDPGKK-------- 70
           +PN     +  + +TK   G+G  G LPW+  + D+K+F  +TT  ++   K        
Sbjct: 19  VPNHGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREK 78

Query: 71  ---------------------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGS 103
                                      N +VMGR +W SIP +Y+PLP R+NVVL+R+  
Sbjct: 79  YLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLK 138

Query: 104 FDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI 163
            +    E++ I  ++           Y     K F+IGG  +++E L     + I+FT I
Sbjct: 139 KE-DVKEDIFIINNMDQLVLLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRI 193

Query: 164 HASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV-----------QSSAAE- 211
           +   ECD F P VD   +Q+   S     N     F  + +            QSS ++ 
Sbjct: 194 NNVYECDVFFPEVDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALTQESLPHQSSGSDK 253

Query: 212 -----------SLSQNT-------------------------------DPL----FDNNS 225
                      ++S NT                               D L    F+NN 
Sbjct: 254 GSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDEEDDLVYFNFNNNK 313

Query: 226 DSLKF--EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRF 283
           +  K      +F     +  + H EY YL +I +II              LSKFG  M+F
Sbjct: 314 NEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKF 373

Query: 284 NLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTE 343
           NL + FPLLTTKK+F RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  
Sbjct: 374 NLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH 433

Query: 344 REEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPV 403
           RE  DLGP+YGFQWRHFGA Y++MH +Y  +G DQL ++I+ IK++P  RRIIL AWN  
Sbjct: 434 REVNDLGPIYGFQWRHFGAEYTNMHANYEDKGVDQLKNIIHLIKNDPTSRRIILCAWNVK 493

Query: 404 DLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P
Sbjct: 494 DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP 553

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
             F+H++G+AHVY+NH+  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H 
Sbjct: 554 AQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEIKNIEDFTISDFTIQNYVHHD 613

Query: 524 K 524
           K
Sbjct: 614 K 614


>E2C405_HARSA (tr|E2C405) Thymidylate synthase OS=Harpegnathos saltator
           GN=EAI_14522 PE=3 SV=1
          Length = 302

 Score =  399 bits (1024), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 187/286 (65%), Positives = 218/286 (76%), Gaps = 1/286 (0%)

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVF 298
           E   Q HEEY YLRLI+++I               S FG Q+RF LR   FPLLTTK+VF
Sbjct: 10  ETTKQEHEEYQYLRLIEKVIKSGTRKGNRTGVDTYSIFGTQLRFGLRDGVFPLLTTKRVF 69

Query: 299 WRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWR 358
           W+ VVEELLWFI GSTN+K L +KGIHIWD N SR +LDS G ++REEGDLGPVYGFQWR
Sbjct: 70  WKAVVEELLWFIKGSTNSKELADKGIHIWDKNGSRAFLDSCGFSDREEGDLGPVYGFQWR 129

Query: 359 HFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQ 418
           H+GA Y DMH DY+GQG DQL +VI+KIKH+P+DRRII+SAWNP D+  MALPPCH F Q
Sbjct: 130 HYGAEYKDMHTDYAGQGIDQLKEVIHKIKHSPDDRRIIMSAWNPTDIPKMALPPCHNFIQ 189

Query: 419 FFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHN 478
           F+V+NGELS Q+YQRSADMGLGVPFNIASY+LL  +IAHV  L PG+FVH +GD HVY N
Sbjct: 190 FYVSNGELSAQLYQRSADMGLGVPFNIASYSLLIYIIAHVTGLKPGEFVHTMGDCHVYIN 249

Query: 479 HVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           HV  L+EQ+   P+ FP LKI  E KDID FVA DF+L+ YNPH K
Sbjct: 250 HVSALEEQIQRKPRNFPKLKIIREIKDIDDFVAEDFELIDYNPHSK 295


>A8C2U4_PLAMA (tr|A8C2U4) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium malariae PE=3 SV=1
          Length = 621

 Score =  399 bits (1024), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 226/601 (37%), Positives = 313/601 (52%), Gaps = 102/601 (16%)

Query: 21  LPNLQRTYQVVVAATKDM-GIGKDGKLPWRLFT-DLKFFKEITTATSDPGKK-------- 70
           +PN     +  + +TK   G+G  G LPW+  + D+K+F  +TT  ++   K        
Sbjct: 19  VPNQGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREK 78

Query: 71  ---------------------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGS 103
                                      N +VMGR +W SIP +Y+PLP R+NVVL+R+  
Sbjct: 79  YLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLK 138

Query: 104 FDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI 163
            +    E++ I  ++           Y     K F+IGG  +++E L     + I+FT I
Sbjct: 139 KE-DVKEDIFIINNMDQLVLLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRI 193

Query: 164 HASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV-----------QSSAAE- 211
           +   ECD F P +D   +Q+   S     N     F  + +            QSS ++ 
Sbjct: 194 NNVYECDVFFPEIDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALTQESLPHQSSGSDK 253

Query: 212 -----------SLSQNT-------------------------------DPL----FDNNS 225
                      ++S NT                               D L    F+NN 
Sbjct: 254 GSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDEEDDLVYFNFNNNK 313

Query: 226 DSLKF--EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRF 283
           +  K      +F     +  + H EY YL +I +II              LSKFG  M+F
Sbjct: 314 NEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKF 373

Query: 284 NLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTE 343
           NL + FPLLTTKK+F RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  
Sbjct: 374 NLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH 433

Query: 344 REEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPV 403
           RE  DLGP+YGFQWRHFGA Y++MH +Y  +G DQL ++I+ IK++P  RRIIL AWN  
Sbjct: 434 REVNDLGPIYGFQWRHFGAEYTNMHANYENKGVDQLKNIIHLIKNDPTSRRIILCAWNVK 493

Query: 404 DLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P
Sbjct: 494 DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP 553

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
             F+H++G+AHVY+NH+  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H 
Sbjct: 554 AQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEIKNIEDFTISDFTIQNYVHHD 613

Query: 524 K 524
           K
Sbjct: 614 K 614


>Q19N43_PLAVI (tr|Q19N43) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  399 bits (1024), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/579 (39%), Positives = 309/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNKKLFHREVNDLGPIYGFQWRHFGAGYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>Q0IJY2_PLAMA (tr|Q0IJY2) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium malariae PE=3 SV=1
          Length = 621

 Score =  399 bits (1024), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 226/601 (37%), Positives = 313/601 (52%), Gaps = 102/601 (16%)

Query: 21  LPNLQRTYQVVVAATKDM-GIGKDGKLPWRLFT-DLKFFKEITTATSDPGKK-------- 70
           +PN     +  + +TK   G+G  G LPW+  + D+K+F  +TT  ++   K        
Sbjct: 19  VPNQGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREK 78

Query: 71  ---------------------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGS 103
                                      N +VMGR +W SIP +Y+PLP R+NVVL+R+  
Sbjct: 79  YLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLK 138

Query: 104 FDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI 163
            +    E++ I  ++           Y     K F+IGG  +++E L     + I+FT I
Sbjct: 139 KE-DVKEDIFIINNMDQLVLLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRI 193

Query: 164 HASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV-----------QSSAAE- 211
           +   ECD F P +D   +Q+   S     N     F  + +            QSS ++ 
Sbjct: 194 NNVYECDVFFPEIDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALTQESLPHQSSGSDK 253

Query: 212 -----------SLSQNT-------------------------------DPL----FDNNS 225
                      ++S NT                               D L    F+NN 
Sbjct: 254 GSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDEEDDLVYFNFNNNK 313

Query: 226 DSLKF--EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRF 283
           +  K      +F     +  + H EY YL +I +II              LSKFG  M+F
Sbjct: 314 NEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKF 373

Query: 284 NLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTE 343
           NL + FPLLTTKK+F RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  
Sbjct: 374 NLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH 433

Query: 344 REEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPV 403
           RE  DLGP+YGFQWRHFGA Y++MH +Y  +G DQL ++I+ IK++P  RRIIL AWN  
Sbjct: 434 REVNDLGPIYGFQWRHFGAEYTNMHANYEDKGVDQLKNIIHLIKNDPTSRRIILCAWNVK 493

Query: 404 DLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P
Sbjct: 494 DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP 553

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
             F+H++G+AHVY+NH+  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H 
Sbjct: 554 AQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEIKNIEDFTISDFTIQNYVHHD 613

Query: 524 K 524
           K
Sbjct: 614 K 614


>I1G066_AMPQE (tr|I1G066) Thymidylate synthase OS=Amphimedon queenslandica
           GN=LOC100639818 PE=3 SV=1
          Length = 318

 Score =  399 bits (1024), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 189/301 (62%), Positives = 218/301 (72%)

Query: 224 NSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRF 283
           N    K E  +   LP  +   H+E  YL L + I+               S FG QMRF
Sbjct: 11  NKLGTKTESVSSGVLPSPVTTNHDECQYLDLCRRILETGKVKEDRTGVGTKSIFGAQMRF 70

Query: 284 NLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTE 343
           +LR  FPLLTTK+VFWRGV EELLWFISG TNAK LQEK IHIWD N S+++L   GL  
Sbjct: 71  DLRDQFPLLTTKRVFWRGVAEELLWFISGCTNAKKLQEKNIHIWDANGSKDFLHKQGLGH 130

Query: 344 REEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPV 403
           REEGDLGPVYGFQWRHFGA+YSDMH DY GQG DQL  VI+ IK NP+ RRII+SAWNPV
Sbjct: 131 REEGDLGPVYGFQWRHFGAQYSDMHFDYDGQGVDQLAQVIHTIKTNPSCRRIIMSAWNPV 190

Query: 404 DLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           D+  MALPPCH F QF+V++GELSCQ+YQRS DMGLGVPFNIASY+LLT MIAHVC+L P
Sbjct: 191 DIPEMALPPCHAFVQFYVSDGELSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHVCDLKP 250

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
           GDFVH +GDAH+Y NH+ PL+EQL   P+ FPTL I+ E K+ID F   DF L GY P+ 
Sbjct: 251 GDFVHTLGDAHIYLNHIEPLKEQLTRTPRAFPTLTIDREVKNIDDFKFEDFSLTGYKPYP 310

Query: 524 K 524
           K
Sbjct: 311 K 311


>Q19N44_PLAVI (tr|Q19N44) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  398 bits (1023), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 225/579 (38%), Positives = 308/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR  WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSNWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNSDSLKFEV-----------------QNFDFLPEMILQR 245
                           P   NN+++ + ++                 Q F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQEFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>Q19N45_PLAVI (tr|Q19N45) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  398 bits (1023), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 223/579 (38%), Positives = 309/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNSDSLKFEV-----------------QNFDFLPEMILQR 245
                           P   NN+++ + ++                 Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREANDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ +K+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLVKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NH   L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHADSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>Q7Z0Z9_BABBO (tr|Q7Z0Z9) Dihydrofolate reductase/thymidilate synthase OS=Babesia
           bovis PE=3 SV=1
          Length = 511

 Score =  398 bits (1023), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 211/504 (41%), Positives = 295/504 (58%), Gaps = 25/504 (4%)

Query: 30  VVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITT------ATSDPGKKNAIVMGRKTWES 82
           + VA   +  IG   ++PW  +  D +F +  TT       + +P  +N ++ GRKT+ES
Sbjct: 13  IYVAIALNRVIGHQNQIPWPHIIHDFRFLRNGTTYIPPEVLSKNPNIQNVVIFGRKTYES 72

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP    PL  R+NV+++R       T + V  C                +   K+F++GG
Sbjct: 73  IPKASLPLKNRINVIISR-------TVKEVPGCLVYEDLSTAIRDLRANVPHNKIFILGG 125

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND-IRYSFAT 201
             +++EVL+   C+ I+ T I+     DTF P +  T +++   S P    D + Y F  
Sbjct: 126 SYLYKEVLDNGLCDKIYLTRINKEYPGDTFFPDIPDT-FEITAIS-PTFSTDFVSYDFVI 183

Query: 202 YVRVQSSAAESLSQNTDPLFDN---NSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEI 258
           Y R      +  +   DP FD        +      +   P + ++ HEE+ YL ++ ++
Sbjct: 184 YER-----KDCKTVFPDPPFDQLLLKGVDIIVPKPKYVACPGVRIRNHEEFQYLDILADV 238

Query: 259 ISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKV 318
           +S              SKFG QMRF+L RSFPLLTTKKV  R ++EELLWFI GSTN   
Sbjct: 239 LSHGVLKPNRTGTDAYSKFGYQMRFDLSRSFPLLTTKKVALRSIIEELLWFIKGSTNGND 298

Query: 319 LQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQ 378
           L  K + IW+ N  RE+LD  G TEREE DLGP+YGFQWRHFGA Y DMH DY+G+G DQ
Sbjct: 299 LLAKNVRIWELNGRREFLDKNGFTEREEHDLGPIYGFQWRHFGAEYLDMHADYTGKGIDQ 358

Query: 379 LLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMG 438
           L ++IN+IK NPNDRR+I+ +WN  DLK MALPPCH F QF+V++ +LSC M+QRS D+G
Sbjct: 359 LAEIINRIKTNPNDRRMIVCSWNVSDLKKMALPPCHCFFQFYVSDNKLSCMMHQRSCDLG 418

Query: 439 LGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLK 498
           LGVPFNIASY++LT M+A VC L  G+FVH + DAH+Y +HV  +  Q+  +P PFP L+
Sbjct: 419 LGVPFNIASYSILTAMVAQVCGLGLGEFVHNLADAHIYVDHVDAVTTQIARIPYPFPRLR 478

Query: 499 INSEKKDIDSFVAADFKLVGYNPH 522
           +N + K+I+ F   D  +  Y  H
Sbjct: 479 LNPDIKNIEDFTIDDIVVEDYVSH 502


>Q5CGA3_CRYHO (tr|Q5CGA3) Chain A, crystal structure of Dhfr OS=Cryptosporidium
           hominis GN=Chro.40506 PE=1 SV=1
          Length = 521

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 221/515 (42%), Positives = 291/515 (56%), Gaps = 33/515 (6%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 89
           VV A+    GIG +G+LPW +  DLKFF +IT    D  KKNA++MGRKTW+SI    RP
Sbjct: 9   VVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSI--GRRP 66

Query: 90  LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 149
           L  R+ VV++ S   D     NVV+  ++              SIE +FV GG  I+R+ 
Sbjct: 67  LKNRIIVVISSSLPQDEADP-NVVVFRNLEDSIENLMNDD---SIENIFVCGGESIYRDA 122

Query: 150 LNAPGCEAIHFTEIH-ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSS 208
           L     + I+ T +    IE DT+ P +  T   ++ S     +N I Y F  + + +  
Sbjct: 123 LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKN-ISYDFMIFEKQEKK 181

Query: 209 AAESLSQNTDPL------FDNNSDSL-------------KFEVQNFDFLPEMILQR-HEE 248
                 QN DP        D+  D L             KF  +     P +   R H E
Sbjct: 182 TL----QNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYE 237

Query: 249 YMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLW 308
           + YL L+  ++               S FG  MRF++R SFPLLTTKKV  R + EEL+W
Sbjct: 238 FQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIW 297

Query: 309 FISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           FI G TN   L EK ++IW GN S+EYL+ IGL  REE DLGP+YGFQWRH+   Y  MH
Sbjct: 298 FIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMH 357

Query: 369 KDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE-LS 427
            DY+G G DQL  +I  +K+NP DRR IL+AWNP  L  MALPPCH+ +Q++V N   LS
Sbjct: 358 DDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLS 417

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           C +YQRS D+GLG PFNIASYA+LT M+A VC   PG+    IGDAH+Y NH+  L+EQL
Sbjct: 418 CNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQL 477

Query: 488 LNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
              P+PFP LK   + ++I+ F   D +L+GY P+
Sbjct: 478 SRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPY 512


>Q27552_CRYPV (tr|Q27552) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Cryptosporidium parvum GN=DHFR-TS PE=1 SV=1
          Length = 521

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 221/515 (42%), Positives = 291/515 (56%), Gaps = 33/515 (6%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 89
           VV A+    GIG +G+LPW +  DLKFF +IT    D  KKNA++MGRKTW+SI    RP
Sbjct: 9   VVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSI--GRRP 66

Query: 90  LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 149
           L  R+ VV++ S   D     NVV+  ++              SIE +FV GG  I+R+ 
Sbjct: 67  LKNRIIVVISSSLPQDEADP-NVVVFRNLEDSIENLMNDD---SIENIFVCGGESIYRDA 122

Query: 150 LNAPGCEAIHFTEIH-ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSS 208
           L     + I+ T +    IE DT+ P +  T   ++ S     +N I Y F  + + +  
Sbjct: 123 LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKN-ISYDFMIFEKQEKK 181

Query: 209 AAESLSQNTDPL------FDNNSDSL-------------KFEVQNFDFLPEMILQR-HEE 248
                 QN DP        D+  D L             KF  +     P +   R H E
Sbjct: 182 TL----QNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYE 237

Query: 249 YMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLW 308
           + YL L+  ++               S FG  MRF++R SFPLLTTKKV  R + EEL+W
Sbjct: 238 FQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIW 297

Query: 309 FISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           FI G TN   L EK ++IW GN S+EYL+ IGL  REE DLGP+YGFQWRH+   Y  MH
Sbjct: 298 FIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMH 357

Query: 369 KDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE-LS 427
            DY+G G DQL  +I  +K+NP DRR IL+AWNP  L  MALPPCH+ +Q++V N   LS
Sbjct: 358 DDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLS 417

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           C +YQRS D+GLG PFNIASYA+LT M+A VC   PG+    IGDAH+Y NH+  L+EQL
Sbjct: 418 CNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQL 477

Query: 488 LNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
              P+PFP LK   + ++I+ F   D +L+GY P+
Sbjct: 478 SRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPY 512


>Q4N262_THEPA (tr|Q4N262) Dihydrofolate reductase-thymidylate synthase, putative
           OS=Theileria parva GN=TP04_0504 PE=3 SV=1
          Length = 522

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 210/515 (40%), Positives = 304/515 (59%), Gaps = 34/515 (6%)

Query: 29  QVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITT------ATSDPGKKNAIVMGRKTWE 81
           +++VA T + GIG    LPW  +  D  F    TT          PG +N I++GRKT++
Sbjct: 12  KLLVAITPENGIGISNGLPWPHIKRDFLFMFRATTYVDPEFKEKHPGAQNVIIIGRKTYD 71

Query: 82  SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFV-- 139
           S+P    PL  R+NVV++R+ +   G      +  +I             L+  K+F+  
Sbjct: 72  SLPEGTFPLKNRINVVISRNLTEVPGGLVFPSMPAAIRHVTEH-------LNYYKIFIMG 124

Query: 140 --------IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDS----TKYQLWYSS 187
                   +GG  ++R+ L+A   + ++ T ++ + +C+ F P +      T     +SS
Sbjct: 125 IFHLNIKHLGGSYVYRDALDARIVDKMYVTRVNKNYKCEVFFPKIPDDFVITGISKTFSS 184

Query: 188 FPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHE 247
                 D  Y F TY R      + + +  + +     +    + Q     P + ++  +
Sbjct: 185 -----EDTTYDFVTYERKDLIVDDRVKKTFEEML-LTGEKFATKDQLVKACPSLKVRYSQ 238

Query: 248 EYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELL 307
           E  YL ++ +I++             ++KFG QMRF+L  SFPLLTTKKVF RG++EEL+
Sbjct: 239 ELQYLEILADILNTGYHKKNRTGVDCIAKFGYQMRFDLSESFPLLTTKKVFLRGIIEELI 298

Query: 308 WFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDM 367
           WFI GSTN   L +K + IW+ N +R +LD++G  +REE DLGPVYGFQWRHFGA+Y DM
Sbjct: 299 WFIKGSTNGNELLKKNVRIWELNGARSFLDNLGFFDREEHDLGPVYGFQWRHFGAKYVDM 358

Query: 368 HKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELS 427
           H DYS QG DQL  VI++IK+NP++RR+I+ +WN  DL  MALPPCH+  QFFVA+G LS
Sbjct: 359 HTDYSNQGIDQLSLVIDRIKNNPDNRRLIVCSWNVADLSKMALPPCHLLFQFFVADGTLS 418

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           C M+QRS DMGLGVPFNIASY+LLT MIA +C L PG+FVH +GDAH+Y+NH+  ++EQ+
Sbjct: 419 CMMHQRSCDMGLGVPFNIASYSLLTYMIAQICGLKPGEFVHNLGDAHIYNNHIDAIKEQI 478

Query: 488 LNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
             +P PFPTL++N +   I+ F   D K+  Y  H
Sbjct: 479 SRVPYPFPTLRLNKDITRIEDFTIDDIKVENYRSH 513


>A8C2U6_PLAMA (tr|A8C2U6) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium malariae PE=3 SV=1
          Length = 621

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 226/601 (37%), Positives = 312/601 (51%), Gaps = 102/601 (16%)

Query: 21  LPNLQRTYQVVVAATKDM-GIGKDGKLPWRLFT-DLKFFKEITTATSDPGKK-------- 70
           +PN     +  + +TK   G+G  G LPW+  + D+K+F  +TT  ++   K        
Sbjct: 19  VPNQGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREK 78

Query: 71  ---------------------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGS 103
                                      N +VMGR +W SIP +Y+PLP R+NVVL+R+  
Sbjct: 79  YLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLK 138

Query: 104 FDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI 163
            +    E++ I  ++           Y     K F+IGG  +++E L     + I+FT I
Sbjct: 139 KE-DVKEDIFIINNMDQLVLLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRI 193

Query: 164 HASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV-----------QSSAAE- 211
           +   ECD F P +D   +Q+   S     N     F  + +            QSS ++ 
Sbjct: 194 NNVYECDVFFPEIDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALTQESLPHQSSGSDK 253

Query: 212 -----------SLSQNT-------------------------------DPL----FDNNS 225
                      ++S NT                               D L    F+NN 
Sbjct: 254 GSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDEEDDLVYFNFNNNK 313

Query: 226 DSLKF--EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRF 283
           +  K      +F     +  + H EY YL +I +II              LSKFG  M+F
Sbjct: 314 NEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKF 373

Query: 284 NLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTE 343
           NL + FPLLTTKK+F RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  
Sbjct: 374 NLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH 433

Query: 344 REEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPV 403
           RE  DLGP+YGFQWRHFGA Y++MH +Y  +G DQL ++I+ IK++P  RRIIL AWN  
Sbjct: 434 REVNDLGPIYGFQWRHFGAEYTNMHANYEDKGVDQLKNIIHLIKNDPTSRRIILCAWNVK 493

Query: 404 DLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P
Sbjct: 494 DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP 553

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
             F+H++G+AHVY NH+  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H 
Sbjct: 554 AQFIHILGNAHVYSNHIDSLKVQLNRIPYPFPTLKLNPEIKNIEDFTISDFTIQNYVHHD 613

Query: 524 K 524
           K
Sbjct: 614 K 614


>A8C2U2_PLAMA (tr|A8C2U2) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium malariae PE=3 SV=1
          Length = 621

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 226/601 (37%), Positives = 312/601 (51%), Gaps = 102/601 (16%)

Query: 21  LPNLQRTYQVVVAATKDM-GIGKDGKLPWRLFT-DLKFFKEITTATSDPGKK-------- 70
           +PN     +  + +TK   G+G  G LPW+  + D+K+F  +TT  ++   K        
Sbjct: 19  VPNQGEGKKNEIFSTKTFRGLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREK 78

Query: 71  ---------------------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGS 103
                                      N +VMGR +W SIP +Y+PLP R+NVVL+R+  
Sbjct: 79  YLEKEISNENSSTVFENISLLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLK 138

Query: 104 FDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI 163
            +    E++ I  ++           Y     K F+IGG  +++E L     + I+FT I
Sbjct: 139 KE-DVKEDIFIINNMDQLVLLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRI 193

Query: 164 HASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV-----------QSSAAE- 211
           +   ECD F P +D   +Q+   S     N     F  + +            QSS ++ 
Sbjct: 194 NNVYECDVFFPEIDENVFQITSVSDVYTSNCTSLDFVIFSKRKKALTQESLPHQSSGSDK 253

Query: 212 -----------SLSQNT-------------------------------DPL----FDNNS 225
                      ++S NT                               D L    F+NN 
Sbjct: 254 GSNTSSTISNGAMSSNTIRGSTTSSSGKGKGGGESIFEREYNFMGDEEDDLVYFNFNNNK 313

Query: 226 DSLKF--EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRF 283
           +  K      +F     +  + H EY YL +I +II              LSKFG  M+F
Sbjct: 314 NEYKNAENANDFKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKF 373

Query: 284 NLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTE 343
           NL + FPLLTTKK+F RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  
Sbjct: 374 NLNQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH 433

Query: 344 REEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPV 403
           RE  DLGP+YGFQWRHFGA Y++MH +Y  +G DQL ++I+ IK++P  RRIIL AWN  
Sbjct: 434 REVNDLGPIYGFQWRHFGAEYTNMHANYEDKGVDQLKNIIHLIKNDPTSRRIILCAWNVK 493

Query: 404 DLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVP 463
           DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P
Sbjct: 494 DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP 553

Query: 464 GDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQ 523
             F+H++G+AHVY+NH+  L+ QL  +P PFPTLK+N E K I+ F  +DF +  Y  H 
Sbjct: 554 AQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEIKSIEDFTISDFTIQNYVHHD 613

Query: 524 K 524
           K
Sbjct: 614 K 614


>Q19PC0_PLAVI (tr|Q19PC0) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  397 bits (1021), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/579 (39%), Positives = 308/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAGAEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG +EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGKIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>C3RUA6_PLAVI (tr|C3RUA6) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 624

 Score =  397 bits (1021), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/585 (38%), Positives = 309/585 (52%), Gaps = 104/585 (17%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F+ +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFRSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIX 119
                     +N +VMGR  WESIP +Y+PLP R+NVVL+++ + +    E V I  SI 
Sbjct: 98  THGGDNADKLQNVVVMGRSNWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSID 156

Query: 120 XXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDST 179
                       L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +
Sbjct: 157 DLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDES 212

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------ 218
           ++++   S           F  Y +V           S A+S S+N +            
Sbjct: 213 QFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAP 272

Query: 219 ----------------------PLFDNNS----DSLKF-------------EVQNFDFLP 239
                                 P   NN+    D L +              +Q+F    
Sbjct: 273 NCRSPNGGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYN 332

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFW 299
            + +++H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F 
Sbjct: 333 SLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFL 392

Query: 300 RGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRH 359
           RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRH
Sbjct: 393 RGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRH 452

Query: 360 FGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQF 419
           FGA Y++MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF
Sbjct: 453 FGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQF 512

Query: 420 FVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNH 479
           +V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NH
Sbjct: 513 YVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNH 572

Query: 480 VRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           V  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 VDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 617


>Q19N42_PLAVI (tr|Q19N42) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  397 bits (1021), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 226/579 (39%), Positives = 308/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG  ++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAHVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNTKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>E9IYA3_SOLIN (tr|E9IYA3) Thymidylate synthase (Fragment) OS=Solenopsis invicta
           GN=SINV_05432 PE=3 SV=1
          Length = 302

 Score =  397 bits (1021), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 186/282 (65%), Positives = 215/282 (76%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           + HEEY YLRLI+++I               S FG QMRF+LR   FPLLTTK+VFWR V
Sbjct: 14  EEHEEYQYLRLIEKVIKTGAKRGNRTGVDTYSIFGAQMRFSLRDGVFPLLTTKRVFWRAV 73

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           VEELLWFI GSTN+K L +KGIHIWD N SR +LDS G T REEGDLGPVYGFQWRHFGA
Sbjct: 74  VEELLWFIKGSTNSKELTDKGIHIWDENGSRAFLDSYGFTNREEGDLGPVYGFQWRHFGA 133

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y DMH DY+ QG DQL +VI+K+KH+P DRRII+SAWNPVD+  MALPPCH F QF+V 
Sbjct: 134 EYKDMHTDYTRQGIDQLKEVIHKVKHSPEDRRIIMSAWNPVDIPKMALPPCHTFVQFYVN 193

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELS Q+YQRSADMGLGVPFNIASY+LLT MIAHV  L PG+FVH +GD HVY NH+  
Sbjct: 194 NGELSAQLYQRSADMGLGVPFNIASYSLLTYMIAHVTGLKPGEFVHTMGDCHVYVNHISA 253

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           L+EQ+   P+ FP LKI  E KDID F+A DF+L+ Y P+ K
Sbjct: 254 LEEQVKREPREFPKLKIVREIKDIDDFIAEDFELIDYKPYAK 295


>C3RUA8_PLAVI (tr|C3RUA8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 624

 Score =  397 bits (1021), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/585 (38%), Positives = 309/585 (52%), Gaps = 104/585 (17%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIX 119
                     +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI 
Sbjct: 98  THGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSID 156

Query: 120 XXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDST 179
                       L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +
Sbjct: 157 DLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDES 212

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------ 218
           ++++   S           F  Y +V           S A+S S+N +            
Sbjct: 213 QFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAP 272

Query: 219 ----------------------PLFDNNS----DSLKF-------------EVQNFDFLP 239
                                 P   NN+    D L +              +Q+F    
Sbjct: 273 NCRSPNGGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYN 332

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFW 299
            + +++H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F 
Sbjct: 333 SLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFL 392

Query: 300 RGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRH 359
           RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRH
Sbjct: 393 RGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRH 452

Query: 360 FGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQF 419
           FGA Y++MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF
Sbjct: 453 FGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQF 512

Query: 420 FVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNH 479
           +V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NH
Sbjct: 513 YVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNH 572

Query: 480 VRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           V  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 VDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 617


>A5K620_PLAVS (tr|A5K620) Bifunctional dihydrofolate reductase-thymidylate
           synthase 1, putative OS=Plasmodium vivax (strain
           Salvador I) GN=PVX_089950 PE=3 SV=1
          Length = 624

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/585 (38%), Positives = 309/585 (52%), Gaps = 104/585 (17%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIX 119
                     +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI 
Sbjct: 98  THGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSID 156

Query: 120 XXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDST 179
                       L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +
Sbjct: 157 DLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDES 212

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------ 218
           ++++   S           F  Y +V           S A+S S+N +            
Sbjct: 213 QFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAP 272

Query: 219 ----------------------PLFDNNS----DSLKF-------------EVQNFDFLP 239
                                 P   NN+    D L +              +Q+F    
Sbjct: 273 NCRSPNGGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYN 332

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFW 299
            + +++H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F 
Sbjct: 333 SLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFL 392

Query: 300 RGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRH 359
           RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRH
Sbjct: 393 RGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRH 452

Query: 360 FGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQF 419
           FGA Y++MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF
Sbjct: 453 FGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQF 512

Query: 420 FVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNH 479
           +V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NH
Sbjct: 513 YVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNH 572

Query: 480 VRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           V  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 VDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 617


>C6GJB8_LITVA (tr|C6GJB8) Thymidylate synthase OS=Litopenaeus vannamei GN=TS PE=2
           SV=1
          Length = 289

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 186/281 (66%), Positives = 219/281 (77%), Gaps = 1/281 (0%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVV 303
           RH+EY YL LI++I+              +S FG QMR++LR   FPLLTTK+VFWRGV 
Sbjct: 2   RHDEYQYLDLIRQIMRTGNRKGDRTGTGTISMFGAQMRYSLRDGIFPLLTTKRVFWRGVA 61

Query: 304 EELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGAR 363
           EELLWF+ GSTNAK LQEK IHIWDGN+S+E+L+ +G  +REEGDLGPVYGFQWRHFGA 
Sbjct: 62  EELLWFVRGSTNAKELQEKDIHIWDGNSSKEFLNKMGFHDREEGDLGPVYGFQWRHFGAP 121

Query: 364 YSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN 423
           Y+DMH DY+GQG DQL  VI+ IK+NP+DRRII+ AWNPVD+  MALPPCH   QF+VAN
Sbjct: 122 YADMHTDYTGQGVDQLQQVIDTIKNNPDDRRIIMCAWNPVDVPKMALPPCHCLCQFYVAN 181

Query: 424 GELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPL 483
           GELSCQ+YQRSADMGLGVPFNIASYALLT MIAHV +L PGDFVH +GDAHVY NH   L
Sbjct: 182 GELSCQLYQRSADMGLGVPFNIASYALLTYMIAHVTDLKPGDFVHTLGDAHVYSNHCEAL 241

Query: 484 QEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           +EQL   P+PFP+LKI  + ++I  F   DF+L GY PH K
Sbjct: 242 EEQLKREPRPFPSLKIKRKVENISDFKFEDFELDGYKPHPK 282


>Q19PB9_PLAVI (tr|Q19PB9) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 226/579 (39%), Positives = 309/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q+FRE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVFRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  ++FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMVKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G T+   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETDGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>Q4YWH2_PLABA (tr|Q4YWH2) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative OS=Plasmodium berghei (strain Anka)
           GN=PB000415.02.0 PE=3 SV=1
          Length = 585

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 216/545 (39%), Positives = 297/545 (54%), Gaps = 61/545 (11%)

Query: 39  GIGKDGKLPWRL-FTDLKFFKEITT---------------------------------AT 64
           GIG  G LPW+    D+K+F  +T+                                  +
Sbjct: 36  GIGNAGVLPWKCNLIDMKYFSSVTSYINENNYIRLKWKRDKYMEKHNLKNNVELNTNIIS 95

Query: 65  SDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXX 124
           S    +N +VMG+K+WESIP K++PL  R+N++L+R+   +    EN     ++      
Sbjct: 96  STNNLQNIVVMGKKSWESIPKKFKPLQNRINIILSRTLKKEDIVNENNNENNNVIIIKSV 155

Query: 125 XXXXPY--CLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQ 182
               P   C    K F+IGG  +++E L+    + I+FT I+ S  CD   P ++   ++
Sbjct: 156 DDLFPILKCTKYYKCFIIGGSSVYKEFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFK 215

Query: 183 LWYSSFPKVENDIRYSFATYVRVQS-SAAESLSQNT--------DPLFDNNSDSLKF--- 230
           +   S     N+    F  Y + +  +  E +  NT        +  FD+  D   F   
Sbjct: 216 ITSISDVYNSNNTTLDFIIYSKTKEINPNEEVPNNTFLGVCDEQNKAFDDEDDYTYFSFN 275

Query: 231 -----------EVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGC 279
                         NF     +  + H EY YL +I ++I              LSKFG 
Sbjct: 276 KNKENIKKNSEHAHNFKIYNSIKYKNHHEYQYLNIIYDMIMHGNNQDDRTGGV-LSKFGY 334

Query: 280 QMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSI 339
            M+FNL   FPLLTTKK+F RG++EELLWFI G TN   L EK + IW+ N +RE+LD  
Sbjct: 335 MMKFNLNEYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDR- 393

Query: 340 GLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSA 399
            L  RE  DLGP+YGFQWRHFGA Y+DMH +Y  +G DQL ++IN IK++P  RRIIL A
Sbjct: 394 KLFHREVNDLGPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNIINLIKNDPTCRRIILCA 453

Query: 400 WNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVC 459
           WN  DL  MALPPCH+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC
Sbjct: 454 WNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVC 513

Query: 460 ELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGY 519
            L   +F+HV+G+AHVY+NH+  L+ QL   P PFPTLK+N + K+I+ F  +DF +  Y
Sbjct: 514 NLQAAEFIHVLGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQNY 573

Query: 520 NPHQK 524
             H K
Sbjct: 574 VHHDK 578


>Q5CPQ4_CRYPI (tr|Q5CPQ4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Cryptosporidium parvum (strain
           Iowa II) GN=cgd4_4460 PE=3 SV=1
          Length = 531

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 219/515 (42%), Positives = 292/515 (56%), Gaps = 33/515 (6%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 89
           VV A+    GIG +G+LPW +  DLKFF +IT+   D  KKNA++MGRKTW+SI    RP
Sbjct: 19  VVAASVLSRGIGINGQLPWSISEDLKFFSKITSNNCDSNKKNALIMGRKTWDSI--GRRP 76

Query: 90  LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 149
           L  R  VV++ S   D     NV++  ++              +IE +FV GG  I+R+ 
Sbjct: 77  LKNRKIVVISSSLPQDEADP-NVIVFRNLEDSIKNLMNDD---TIENIFVCGGESIYRDA 132

Query: 150 LNAPGCEAIHFTEIH-ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSS 208
           L     + I+ T +    IE DT+ P +  T   ++ S     +N I Y F  + + +  
Sbjct: 133 LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKN-ISYDFMVFEKQEKK 191

Query: 209 AAESLSQNTDPL------FDNNSDSL-------------KFEVQNFDFLPEMILQR-HEE 248
                 QN DP+       D+  D L             KF  +     P +   R H E
Sbjct: 192 TL----QNCDPVRGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYE 247

Query: 249 YMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLW 308
           + YL L+  ++               S FG  MRF++R SFPLLTTKKV  R + EEL+W
Sbjct: 248 FQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIW 307

Query: 309 FISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           FI G TN   L EK ++IW GN S+EYL+ IGL  REE DLGP+YGFQWRH+   Y  MH
Sbjct: 308 FIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMH 367

Query: 369 KDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE-LS 427
            DY+G G DQL  +I  +K+NP DRR IL+AWNP  L  MALPPCH+ +Q++V N   LS
Sbjct: 368 DDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLS 427

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           C +YQRS D+GLG PFNIASYA+LT M+A VC   PG+    IGDAH+Y NH+  L+EQL
Sbjct: 428 CNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQL 487

Query: 488 LNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
              P+PFP LK   + ++I+ F   D +L+GY P+
Sbjct: 488 SRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPY 522


>C3RUA7_PLAVI (tr|C3RUA7) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 624

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/585 (38%), Positives = 309/585 (52%), Gaps = 104/585 (17%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTHGGDN 97

Query: 70  ----------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIX 119
                     +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI 
Sbjct: 98  THGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSID 156

Query: 120 XXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDST 179
                       L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +
Sbjct: 157 DLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDES 212

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------ 218
           ++++   S           F  Y +V           S A+S S+N +            
Sbjct: 213 QFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAP 272

Query: 219 ----------------------PLFDNNS----DSLKF-------------EVQNFDFLP 239
                                 P   NN+    D L +              +Q+F    
Sbjct: 273 NCRSPNGGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYN 332

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFW 299
            + +++H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F 
Sbjct: 333 SLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFL 392

Query: 300 RGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRH 359
           RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRH
Sbjct: 393 RGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRH 452

Query: 360 FGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQF 419
           FGA Y++MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF
Sbjct: 453 FGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQF 512

Query: 420 FVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNH 479
           +V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NH
Sbjct: 513 YVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNH 572

Query: 480 VRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           V  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 VDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 617


>C3RUB1_PLAVI (tr|C3RUB1) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 624

 Score =  397 bits (1019), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 227/585 (38%), Positives = 308/585 (52%), Gaps = 104/585 (17%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIX 119
                     +N +VMGR  WESIP +Y+PLP R+NVVL+++ + +    E V I  SI 
Sbjct: 98  THGGDNADKLQNVVVMGRSNWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDSID 156

Query: 120 XXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDST 179
                       L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +
Sbjct: 157 DLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDES 212

Query: 180 KYQLWYSSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------ 218
           ++++   S           F  Y +V           S A+S S+N +            
Sbjct: 213 QFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAP 272

Query: 219 ----------------------PLFDNNS----DSLKF-------------EVQNFDFLP 239
                                 P   NN+    D L +              +Q+F    
Sbjct: 273 NCRSPNGGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYN 332

Query: 240 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFW 299
            + +++H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F 
Sbjct: 333 SLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFL 392

Query: 300 RGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRH 359
           RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRH
Sbjct: 393 RGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRH 452

Query: 360 FGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQF 419
           FGA Y++MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF
Sbjct: 453 FGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQF 512

Query: 420 FVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNH 479
           +V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NH
Sbjct: 513 YVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNH 572

Query: 480 VRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           V  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 VDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 617


>D2A1S6_TRICA (tr|D2A1S6) Putative uncharacterized protein GLEAN_07732
           OS=Tribolium castaneum GN=GLEAN_07732 PE=3 SV=1
          Length = 330

 Score =  396 bits (1018), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 196/326 (60%), Positives = 227/326 (69%), Gaps = 17/326 (5%)

Query: 204 RVQSSAAESLSQNT----DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEII 259
           +   S  E++S N     D   D  + SL  E            Q HEEY YL  I+ II
Sbjct: 10  QTDDSNKENISDNPLNIGDTCRDTKTSSLPLE------------QEHEEYQYLSHIKLII 57

Query: 260 SEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEELLWFISGSTNAKV 318
            +             S FG QMR++LR + FPLLTTK+VFWRGVVEELLWFI GSTNA  
Sbjct: 58  DKGVKKSDRTGVGTFSIFGAQMRYSLRDNVFPLLTTKRVFWRGVVEELLWFIKGSTNANE 117

Query: 319 LQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQ 378
           L+EK +HIWD N++RE+LDS+GL EREEGDLGPVYGFQWRHFGA Y  MH DY+ QG DQ
Sbjct: 118 LKEKNVHIWDANSTREFLDSVGLNEREEGDLGPVYGFQWRHFGAEYKGMHWDYANQGIDQ 177

Query: 379 LLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMG 438
           L  VI  I++ PNDRRII+ AWNPVD+  MALPPCH   QFFVANGELSC +YQRSADMG
Sbjct: 178 LAHVIETIRNKPNDRRIIMCAWNPVDIPEMALPPCHCLVQFFVANGELSCLLYQRSADMG 237

Query: 439 LGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLK 498
           LGVPFNIASY+LLT MIAHV  L PG+F+H +GD+HVY NHV PLQEQL   P+PFPTLK
Sbjct: 238 LGVPFNIASYSLLTYMIAHVTGLKPGEFIHTLGDSHVYLNHVEPLQEQLKRTPRPFPTLK 297

Query: 499 INSEKKDIDSFVAADFKLVGYNPHQK 524
           I  +   I+ FV  DF+L GY PH K
Sbjct: 298 IKRQVSSIEDFVFDDFELSGYEPHPK 323


>D3VZW0_9APIC (tr|D3VZW0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Plasmodium billcollinsi GN=DHFR-TS PE=3 SV=1
          Length = 607

 Score =  395 bits (1016), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 216/570 (37%), Positives = 301/570 (52%), Gaps = 92/570 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           GIG  G LPW+  + D+K+F  +TT  +                          P  K  
Sbjct: 39  GIGNKGVLPWKCNSLDMKYFCAVTTYVNASKYEKLKYKRCKYLNKETLDNVIDMPNSKKL 98

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   I        
Sbjct: 99  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKIEDLIVLLG 154

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + ++FT I+++ ECD F P ++  +YQ+   
Sbjct: 155 KLNY----YKCFIIGGSVVYKEFLEKKLIKKVYFTRINSTYECDVFFPEINENEYQIISV 210

Query: 187 SFPKVENDIRYSFATYVRV------QSSAAESLSQNTDPLFDN----------------N 224
           S     N+    F  Y +       +    +   +N D    N                N
Sbjct: 211 SDVYTSNNTTLDFIIYKKKNNKLLNEQDCIKGEEKNNDMSLKNDDKDTYNMKKLTDFYKN 270

Query: 225 SDSLKFEV------------------------------QNFDFLPEMILQRHEEYMYLRL 254
            D  K                                  +F     +  + H EY YL +
Sbjct: 271 VDKYKINYEDDDDDEEDDFVYFNFNKEKEEKNKNSVHPNDFQIYNSLKYKYHPEYQYLNI 330

Query: 255 IQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGST 314
           I +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G T
Sbjct: 331 IYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGET 390

Query: 315 NAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQ 374
           N   L  K + IW+ N +R++LD+  L  RE  DLGP+YGFQWRHFGA Y++MH +Y  +
Sbjct: 391 NGNTLLNKNVRIWEANGTRDFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYENK 450

Query: 375 GYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRS 434
           G DQL ++++ IK++P  RRI+L AWN  DL  MALPPCH+  QF+V +G+LSC MYQRS
Sbjct: 451 GVDQLKNIVDLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRS 510

Query: 435 ADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPF 494
            D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P PF
Sbjct: 511 CDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPF 570

Query: 495 PTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           PTLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 571 PTLKLNPDIKNIEDFTISDFTIQNYVHHEK 600


>D3VZV9_PLARE (tr|D3VZV9) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Plasmodium reichenowi GN=DHFR-TS
           PE=3 SV=1
          Length = 598

 Score =  395 bits (1016), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 219/569 (38%), Positives = 303/569 (53%), Gaps = 91/569 (15%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITTATSD-------------------------PGKK-- 70
           G+G  G LPW+  + D+K+F  +TT  ++                         P  K  
Sbjct: 31  GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLKKETVDNVNDMPNSKKL 90

Query: 71  -NAIVMGRKTWESIPLKYRPLPGRLNVVLTRS---GSFDIGTAENVVICGSIXXXXXXXX 126
            N +VMGR +WESIP K++PL  R+NV+L+R+     FD    E+V I   +        
Sbjct: 91  QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 146

Query: 127 XXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS 186
              Y     K F+IGG  +++E L     + I+FT I+++ ECD F P ++  +YQ+   
Sbjct: 147 KLNY----YKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPAINENEYQIISV 202

Query: 187 SFPKVENDIRYSFATY------VRVQSSAAESLSQNTD-PL---------------FDNN 224
           S     N+    F  Y      V  +    +   +N D PL               F  N
Sbjct: 203 SDVYTSNNTTLDFIIYQKKNNKVLNEQDCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 262

Query: 225 SDSLKFEVQN-----------------------------FDFLPEMILQRHEEYMYLRLI 255
            D  K   +N                             F     +  + H EY YL +I
Sbjct: 263 VDKYKINYENDDDGEDDFVYFNFNKEKEEKNKNSVHANDFQIYNSLKYKYHPEYQYLNII 322

Query: 256 QEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTN 315
            +I+              LSKFG  M+F+L + FPLLTTKK+F RG++EELLWFI G TN
Sbjct: 323 YDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETN 382

Query: 316 AKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQG 375
              L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y++M+ +Y  +G
Sbjct: 383 GNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKG 442

Query: 376 YDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSA 435
            DQL ++IN IK++P  RRI+L AWN  D   MAL PCH+  QF+V +G+LSC MYQRS 
Sbjct: 443 VDQLKNIINLIKNDPTSRRILLCAWNVKDFDQMALLPCHILCQFYVFDGKLSCIMYQRSC 502

Query: 436 DMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFP 495
           D+GLGVPFNIASY++ T MIA VC L P  F+HV+G+AHVY+NH+  L+ QL  +P PFP
Sbjct: 503 DLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFP 562

Query: 496 TLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           TLK+N + K+I+ F  +DF +  Y  H+K
Sbjct: 563 TLKLNPDIKNIEDFTISDFTIQNYVHHEK 591


>Q19N40_PLAVI (tr|Q19N40) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  395 bits (1016), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 226/579 (39%), Positives = 308/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I  SI       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-EVKEKVFIIDSIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SKFG  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MAL PCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALLPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>A7ASX7_BABBO (tr|A7ASX7) Dihydrofolate reductase/thymidylate synthase OS=Babesia
           bovis GN=BBOV_II000780 PE=1 SV=1
          Length = 511

 Score =  395 bits (1015), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 208/504 (41%), Positives = 293/504 (58%), Gaps = 25/504 (4%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFT-DLKFFKEITT------ATSDPGKKNAIVMGRKTWES 82
           + VA   +  IG   ++PW   T D +F +  TT       + +P  +N ++ GRKT+ES
Sbjct: 13  IFVAVALNKVIGHKNQIPWPHITHDFRFLRNGTTYIPPEVLSKNPDIQNVVIFGRKTYES 72

Query: 83  IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 142
           IP    PL  R+NV+L+R       T + V  C                +   K+F++GG
Sbjct: 73  IPKASLPLKNRINVILSR-------TVKEVPGCLVYEDLSTAIRDLRANVPHNKIFILGG 125

Query: 143 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND-IRYSFAT 201
             +++EVL+   C+ I+ T ++     DT+ P +  T +++   S P    D + Y F  
Sbjct: 126 SFLYKEVLDNGLCDKIYLTRLNKEYPGDTYFPDIPDT-FEITAIS-PTFSTDFVSYDFVI 183

Query: 202 YVRVQSSAAESLSQNTDPLFDN---NSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEI 258
           Y R             DP FD        +      +   P + ++ HEE+ YL ++ ++
Sbjct: 184 YERKDCKTVFP-----DPPFDQLLMTGTDISVPKPKYVACPGVRIRNHEEFQYLDILADV 238

Query: 259 ISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKV 318
           +S              SKFG QMRF+L RSFPLLTTKKV  R ++EELLWFI GSTN   
Sbjct: 239 LSHGVLKPNRTGTDAYSKFGYQMRFDLSRSFPLLTTKKVALRSIIEELLWFIKGSTNGND 298

Query: 319 LQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQ 378
           L  K + IW+ N  R++LD  G T+REE DLGP+YGFQWRHFGA Y DMH DY+G+G DQ
Sbjct: 299 LLAKNVRIWELNGRRDFLDKNGFTDREEHDLGPIYGFQWRHFGAEYLDMHADYTGKGIDQ 358

Query: 379 LLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQMYQRSADMG 438
           L ++IN+IK NPNDRR+I+ +WN  DLK MALPPCH F QF+V++ +LSC M+QRS D+G
Sbjct: 359 LAEIINRIKTNPNDRRLIVCSWNVSDLKKMALPPCHCFFQFYVSDNKLSCMMHQRSCDLG 418

Query: 439 LGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLK 498
           LGVPFNIASY++LT M+A VC L  G+FVH + DAH+Y +HV  +  Q+  +P PFP L+
Sbjct: 419 LGVPFNIASYSILTAMVAQVCGLGLGEFVHNLADAHIYVDHVDAVTTQIARIPHPFPRLR 478

Query: 499 INSEKKDIDSFVAADFKLVGYNPH 522
           +N + ++I+ F   D  +  Y  H
Sbjct: 479 LNPDIRNIEDFTIDDIVVEDYVSH 502


>H9HVD5_ATTCE (tr|H9HVD5) Uncharacterized protein OS=Atta cephalotes PE=3 SV=1
          Length = 317

 Score =  395 bits (1014), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 183/282 (64%), Positives = 216/282 (76%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           + HEEY YLRLI+++I               S FG QMRF+LR   FPLLTTK+VFWR V
Sbjct: 29  KEHEEYQYLRLIEKVIHSGAKKSNRTGVDIYSIFGTQMRFSLRDGVFPLLTTKQVFWRAV 88

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           +EELLWFI GSTN+K L +KGIHIWD N SR +LDS G T+REEGDLGPVYGFQWR+FGA
Sbjct: 89  IEELLWFIKGSTNSKELSDKGIHIWDENGSRAFLDSCGFTDREEGDLGPVYGFQWRYFGA 148

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y DMH +Y+GQG DQL +VI+KIKH+P DRRII+SAWNPVD+  MALPPCH   QF+V 
Sbjct: 149 EYKDMHTNYTGQGIDQLKEVIHKIKHSPEDRRIIMSAWNPVDIPKMALPPCHTLVQFYVN 208

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELS Q+YQRSADMGLGVPFNIASY+LLT MIAHV  L PG+FVH +GD HVY NH+  
Sbjct: 209 NGELSTQLYQRSADMGLGVPFNIASYSLLTYMIAHVTGLKPGEFVHTMGDCHVYVNHISA 268

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           L+EQ+   P+ FP L+I  E KDID F+  DF+L+ YNP+ K
Sbjct: 269 LEEQVKREPREFPKLRIVREVKDIDDFITEDFELINYNPYSK 310


>C3RUB2_PLAVI (tr|C3RUB2) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 630

 Score =  395 bits (1014), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 225/591 (38%), Positives = 310/591 (52%), Gaps = 110/591 (18%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----------------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVV 113
                           +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V 
Sbjct: 98  THGGDNTHGVDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVF 156

Query: 114 ICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFM 173
           I  SI             L   K F+IGG Q++RE L+    + I+FT I+ +  CD F 
Sbjct: 157 IIDSIDDLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFF 212

Query: 174 PPVDSTKYQLWYSSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------ 218
           P  D +++++   S           F  Y +V           S A+S S+N +      
Sbjct: 213 PEFDESQFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNA 272

Query: 219 ----------------------------PLFDNNSDSLKFEV-----------------Q 233
                                       P   NN+++ + ++                 Q
Sbjct: 273 PKCSAPNCRSPNGGTAQQGEWGKGPAACPWQKNNAEAEEDDLVYFSFNNKVGEKNPEHLQ 332

Query: 234 NFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLT 293
           +F     + +++H EY YL +I +II              +SKFG  M+FNL   FPLLT
Sbjct: 333 DFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLT 392

Query: 294 TKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVY 353
           TKK+F RG++EELLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+Y
Sbjct: 393 TKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIY 452

Query: 354 GFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPC 413
           GFQWRHFGA Y++MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPC
Sbjct: 453 GFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPC 512

Query: 414 HMFAQFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDA 473
           H+  QF+V +G+LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+A
Sbjct: 513 HILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNA 572

Query: 474 HVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           HVY+NHV  L+ QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 HVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 623


>A7RH38_NEMVE (tr|A7RH38) Predicted protein OS=Nematostella vectensis
           GN=v1g227987 PE=3 SV=1
          Length = 306

 Score =  395 bits (1014), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 185/282 (65%), Positives = 213/282 (75%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           +RH+E  YL +I+ I+               S FG QMRF+LR   FPLLTTK+VFWRGV
Sbjct: 18  KRHDELQYLDMIRYIMENGTVKTDRTGTGTKSVFGAQMRFSLRDGVFPLLTTKRVFWRGV 77

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
            EELLWF+ G TNAKVL +K IHIWD N SR +LD  GL+ REEGDLGPVYGFQWRHFGA
Sbjct: 78  AEELLWFVKGCTNAKVLADKNIHIWDANGSRGFLDRQGLSHREEGDLGPVYGFQWRHFGA 137

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
           +Y DMH DY+GQG DQL  VI+KIK+NP+DRRII+ AWNP D+ LMALPPCH F QF+VA
Sbjct: 138 KYVDMHTDYTGQGVDQLAQVIDKIKNNPDDRRIIMLAWNPSDIPLMALPPCHAFVQFYVA 197

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELSCQ+YQRS DMGLGVPFNIASY+LLT MIAHVC L PGDFVH +GDAHVY NH   
Sbjct: 198 NGELSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHVCGLKPGDFVHSLGDAHVYLNHFEA 257

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           L+EQL   P+ FP+L I  +  DID F   DF++VGY PH K
Sbjct: 258 LEEQLKREPRAFPSLVIKRQVDDIDQFTFDDFEIVGYKPHPK 299


>Q19N41_PLAVI (tr|Q19N41) Dihydrofolate reductase-thymidylate synthase
           OS=Plasmodium vivax GN=DHFR-TS PE=3 SV=1
          Length = 618

 Score =  394 bits (1013), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 225/579 (38%), Positives = 307/579 (53%), Gaps = 98/579 (16%)

Query: 39  GIGKDGKLPWRLFT-DLKFFKEITT---------------------ATSDPGK------- 69
           G+G  G LPW+  + D+K+F  +TT                     A+   G        
Sbjct: 38  GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97

Query: 70  ----KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXX 125
               +N +VMGR +WESIP +Y+PLP R+NVVL+++ + +    E V I   I       
Sbjct: 98  ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKE-DVKEKVFIIDRIDDLLLLL 156

Query: 126 XXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWY 185
                 L   K F+IGG Q++RE L+    + I+FT I+ +  CD F P  D +++++  
Sbjct: 157 KK----LKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS 212

Query: 186 SSFPKVENDIRYSFATYVRV---------QSSAAESLSQNTD------------------ 218
            S           F  Y +V           S A+S S+N +                  
Sbjct: 213 VSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSASENCNALNCNAPKCSAPNCRSPN 272

Query: 219 ----------------PLFDNNS----DSLKF-------------EVQNFDFLPEMILQR 245
                           P   NN+    D L +              +Q+F     + +++
Sbjct: 273 GGTAQQGEWGKGPAACPWQKNNAEAGEDDLVYFSFNNKVGEKNPEHLQDFKIYNSLKIKQ 332

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H EY YL +I +II              +SK G  M+FNL   FPLLTTKK+F RG++EE
Sbjct: 333 HPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKCGYMMKFNLSEYFPLLTTKKLFLRGIIEE 392

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI G TN   L  K + IW+ N +RE+LD+  L  RE  DLGP+YGFQWRHFGA Y+
Sbjct: 393 LLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYT 452

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           +MH +Y  +G DQL +VI+ IK+ P  RRIIL AWN  DL  MALPPCH+  QF+V +G+
Sbjct: 453 NMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGK 512

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSC MYQRS D+GLGVPFNIASY++ T MIA VC L P  F+H++G+AHVY+NHV  L+ 
Sbjct: 513 LSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKV 572

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           QL  +P PFPTLK+N E K+I+ F  +DF +  Y  H K
Sbjct: 573 QLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDK 611


>B3NAN1_DROER (tr|B3NAN1) GG24473 OS=Drosophila erecta GN=Dere\GG24473 PE=3 SV=1
          Length = 304

 Score =  393 bits (1009), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 184/280 (65%), Positives = 215/280 (76%), Gaps = 1/280 (0%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
            +E  YL L+ EI++             LS FGCQMRFN+R SFPLLTTK+VF+R V EE
Sbjct: 18  RDEMQYLDLLSEILANGEQRMDRTEVGTLSMFGCQMRFNMRESFPLLTTKRVFFRAVAEE 77

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWF++G T+AK+LQ K +HIWDGN+SRE+LDS+GLTER  GDLGPVYGFQWRHFGA Y+
Sbjct: 78  LLWFVAGKTDAKLLQAKNVHIWDGNSSREFLDSLGLTERSVGDLGPVYGFQWRHFGAEYA 137

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN-G 424
               DYSG+G DQL  VI+ IK+NP+DRRIILSAWNPVD+  M LPPCH  AQFFV+  G
Sbjct: 138 TCDDDYSGKGIDQLRRVIDTIKNNPSDRRIILSAWNPVDMPKMVLPPCHCLAQFFVSTRG 197

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRSADMGLGVPFNIASYALLT MIAHV  L PGDFVH +GD HVY NHV PL+
Sbjct: 198 ELSCQLYQRSADMGLGVPFNIASYALLTYMIAHVTGLKPGDFVHTMGDTHVYLNHVEPLK 257

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           EQL   P+PFP L I  + +DID F   DF++V YNP+ K
Sbjct: 258 EQLKRTPRPFPKLNIKRQVQDIDDFRFEDFEIVDYNPYPK 297


>F4X867_ACREC (tr|F4X867) Thymidylate synthase OS=Acromyrmex echinatior
           GN=G5I_14671 PE=3 SV=1
          Length = 513

 Score =  392 bits (1007), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 182/282 (64%), Positives = 215/282 (76%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           + HEEY YLRLI+++I               S FG QMRF+LR   FPLLTTK+VFWR V
Sbjct: 225 KEHEEYQYLRLIEKVIQSGAKKSNRTAMDTYSIFGAQMRFSLRDGVFPLLTTKQVFWRAV 284

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           +EELLWFI GSTN+K L +KGIHIWD N SR +LDS   T+REEGDLGPVYGFQWRHFGA
Sbjct: 285 IEELLWFIKGSTNSKELSDKGIHIWDENGSRAFLDSCDFTDREEGDLGPVYGFQWRHFGA 344

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y DMH DY+GQG DQL +VI+K+KH+P DRRII+SAWNP+D+  MALPPCH   QF+V 
Sbjct: 345 EYKDMHTDYTGQGIDQLKEVIHKVKHSPEDRRIIISAWNPIDIPKMALPPCHTLVQFYVN 404

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELS Q+YQRSADMGLGVPFNIASY+LLT MIAHV  L PG+FVH +GD HVY NH+  
Sbjct: 405 NGELSTQLYQRSADMGLGVPFNIASYSLLTYMIAHVTGLKPGEFVHTMGDCHVYVNHISA 464

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           L++Q+   P+ FP L+I  E KDID F+  DFKL+ YNP+ K
Sbjct: 465 LEKQVKREPREFPKLRIVREVKDIDDFITEDFKLIDYNPYSK 506


>F0VQW6_NEOCL (tr|F0VQW6) Bifunctional dihydrofolate reductase-thymidylate
           synthase, related OS=Neospora caninum (strain Liverpool)
           GN=NCLIV_065390 PE=3 SV=1
          Length = 690

 Score =  392 bits (1006), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 237/656 (36%), Positives = 323/656 (49%), Gaps = 155/656 (23%)

Query: 23  NLQRTYQVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDPGKK----------- 70
           N+Q+   ++ A T   GIG +  LPW  L TD K F  +T  T+D   +           
Sbjct: 29  NMQKPVSLIAAMTPRRGIGVNNGLPWPHLATDFKHFSRVTKTTADEVSRLNAWLPKKIAK 88

Query: 71  ----------------NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAEN--- 111
                           NA+VMGRKTWES+PLK+RPL  RLN+V++ S   +   AE    
Sbjct: 89  TGDSGLPSPAFGVNRFNAVVMGRKTWESLPLKFRPLVDRLNIVVSSSLKEEDIAAEKPLV 148

Query: 112 -----VVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHAS 166
                V +C S+           Y  S+++++V+GG  ++ E L+      ++ T +   
Sbjct: 149 EGQQRVRVCDSLPAALRLVDEE-YRESVDQIYVVGGAGLYEEALSLGVVSHLYITRVARD 207

Query: 167 IECDTFMP--PVDS-----------------------------------TKYQLWYSSFP 189
             CD F P  P DS                                     Y+  + S  
Sbjct: 208 FPCDVFFPAFPGDSILSNKQAASASQPSAAAEPVFVPFCPQLGREKSNEASYRPIFISKT 267

Query: 190 KVENDIRYSFATYVRVQSSAAESLSQN------------TDPLFDNNSDSLKFEVQNFDF 237
             +N + Y F    + + + A S +++            T P     S S     Q   +
Sbjct: 268 YSDNGVPYDFVVLEKGRKADACSATESCELRGPWTSTGETSPETRLPSSSASAVAQVLAW 327

Query: 238 LPEMILQRHEEYMYLR-----------------LIQEIISEXXXXXXXXXXXXLSKFGCQ 280
           + +   ++ E+   +R                 LI +II+             +SKFGC 
Sbjct: 328 MADEDRKKCEKKEIIRAVPHVHFRGHEEFQYLDLIADIINNGATMDDRTGVGVISKFGCT 387

Query: 281 MRFNLRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGI---------------- 324
           MRF+L ++FPLLTTK+VFW+GV+EELLWFI G TNA  L EKG+                
Sbjct: 388 MRFSLDKAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKASLQAPLLSFRLLRR 447

Query: 325 ---------------------------------HIWDGNASREYLDSIGLTEREEGDLGP 351
                                             IWD N +RE+LDS  L+ RE GD+GP
Sbjct: 448 LGAFLRGVTPPRLHAYIECTRLSSRPSAAFAGPRIWDKNVTREFLDSRNLSHREVGDIGP 507

Query: 352 VYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALP 411
            YGFQWRHFGA Y DMH DY+GQG DQL  VIN ++ NP DRR++++AWNP  L  MALP
Sbjct: 508 GYGFQWRHFGATYKDMHTDYTGQGVDQLKKVINMLRTNPTDRRMLMTAWNPAALDEMALP 567

Query: 412 PCHMFAQFFVANG-ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVI 470
           PCH+  QF+V N  +LSC MYQRS D+GLGVPFNIASY+LLT M+AHVC L P +F+H +
Sbjct: 568 PCHLLCQFYVENDRDLSCVMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFM 627

Query: 471 GDAHVYHNHVRPLQEQLLNLPKPFPTLKI-NSEK-KDIDSFVAADFKLVGYNPHQK 524
           G+ HVY NHV  L+EQL   P+PFP + I N E+ ++ID F A DF++VGY PH +
Sbjct: 628 GNTHVYSNHVEALKEQLRREPRPFPIVNILNKERIQEIDDFTAEDFEVVGYVPHGR 683


>D2W4C0_NAEGR (tr|D2W4C0) Predicted protein OS=Naegleria gruberi
           GN=NAEGRDRAFT_76251 PE=3 SV=1
          Length = 535

 Score =  390 bits (1001), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 228/538 (42%), Positives = 299/538 (55%), Gaps = 76/538 (14%)

Query: 30  VVVAATKDMGIGKDGKLPWR---LFTDLKFFKEITTATSDPGK----------------- 69
           VV       GIG +G LPW    L  D+K F  +T  +S+P K                 
Sbjct: 20  VVAVLLNSNGIGLNGNLPWLQDGLTEDMKHFVSVT-CSSEPLKFISPSMYKQSSSSSPIT 78

Query: 70  ---------------KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIG--TAENV 112
                           NA++MGRKTWESIP K++PL    + ++  S   D      E  
Sbjct: 79  SDNTNDNTTTINDQLMNAVIMGRKTWESIPSKFKPLSKNRHAIILSSKVNDDDQLMMERT 138

Query: 113 VICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI----HASIE 168
               ++           +     ++F+ GG  I++ +L  P    IH+T I      +I+
Sbjct: 139 TFVKNVDELFELLQNQKF----NRIFIAGGTSIYKLLL--PYTAVIHYTNIIEQKGVNIQ 192

Query: 169 CDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSL 228
            DT  P       +L  SS      D R      V + S+   ++ ++   L  NN    
Sbjct: 193 VDTRFP------IRLLPSS------DYRN-----VPINSNQFIAVDKSDKILPKNNERIS 235

Query: 229 KFEVQNFDFLPEMILQRHEEYMYLRLIQEII-SEXXXXXXXXXXXXLSKFGCQMRFNLRR 287
            +E   F+       +RHEE+ YL +I+E+I S+            +SKFG QM+++LR 
Sbjct: 236 HYEFITFE-------RRHEEFQYLDIIKELILSDINVREERTGVGTVSKFGYQMKYSLRN 288

Query: 288 S-FPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREE 346
           + FPLLTTK+VFW+GV +EL WFISGSTNAK+L E+ IHIWDGN SREYLDS+G   REE
Sbjct: 289 NVFPLLTTKRVFWKGVAKELFWFISGSTNAKILSEQDIHIWDGNGSREYLDSLGFENREE 348

Query: 347 GDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLK 406
            DLGPVYGFQWRH+G+ Y +MH DY+ +G DQL   I  +K+NP +RRIILSAWN  DL 
Sbjct: 349 MDLGPVYGFQWRHWGSSYENMHTDYTNKGVDQLKKCIETLKNNPTNRRIILSAWNVSDLP 408

Query: 407 LMALPPCHMFAQFFV--ANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPG 464
            MALPPCH+  QF+V     ELSCQMYQRS DMGLGVPFNIASYALLT ++A VC L PG
Sbjct: 409 NMALPPCHLMCQFWVDTDTNELSCQMYQRSCDMGLGVPFNIASYALLTRLMAQVCNLKPG 468

Query: 465 DFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           DF+H +GD HVY NH+ PL++Q+   PK FP L ++    +ID F      L  Y PH
Sbjct: 469 DFIHTLGDTHVYKNHIEPLKKQIERDPKHFPLLLLDPSITNIDDFKFEHLTLQNYEPH 526


>F7G371_MONDO (tr|F7G371) Thymidylate synthase OS=Monodelphis domestica
           GN=LOC100013725 PE=3 SV=2
          Length = 335

 Score =  388 bits (997), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 181/280 (64%), Positives = 211/280 (75%)

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGV 302
           LQ H E  YL+ I+ I+              +S FG Q R+NLR  FPLLTTK+VFW+GV
Sbjct: 47  LQMHGEKQYLQQIEHILQYGSKKNDRTGTGTMSVFGMQARYNLRGEFPLLTTKRVFWKGV 106

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           +EELLWFI G TN K L  KG+ IWD N SRE+LD++GLT+REEGDLGPVYGFQWRHFGA
Sbjct: 107 LEELLWFIRGCTNGKELSAKGVKIWDANGSREFLDNLGLTQREEGDLGPVYGFQWRHFGA 166

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y +M+ DYSGQG DQL  VI+KIK NP+DRR+I+ AWNP DL LMALPPCH   QF+VA
Sbjct: 167 EYKEMNTDYSGQGVDQLQKVIDKIKTNPDDRRLIMCAWNPKDLPLMALPPCHALCQFYVA 226

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELSCQ+YQRS DMGLGVPFNIASY+LLT MIAH+  L PGDFVH +GDAHVY NH+ P
Sbjct: 227 NGELSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHITGLKPGDFVHSLGDAHVYMNHIEP 286

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           L+ QL   P+PFP LKI  + + ID F A DF + GYNPH
Sbjct: 287 LKIQLQREPRPFPKLKILRKVESIDDFKAEDFLIEGYNPH 326


>H0VTN7_CAVPO (tr|H0VTN7) Uncharacterized protein OS=Cavia porcellus
           GN=LOC100720541 PE=3 SV=1
          Length = 314

 Score =  388 bits (996), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 179/280 (63%), Positives = 208/280 (74%)

Query: 243 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGV 302
           L  H E  YLR ++ I+              LS FG Q R++LR  FPLLTTK+VFW+G+
Sbjct: 26  LAPHGELQYLRQVEHILRSGFHKEDRTGTGTLSVFGMQARYSLRDQFPLLTTKRVFWKGI 85

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           +EELLWFI GSTNAK L  KG+ IWD N SR++LDS+G + R+EGDLGP+YGFQWRHFGA
Sbjct: 86  LEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSSRQEGDLGPIYGFQWRHFGA 145

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V 
Sbjct: 146 EYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHTLCQFYVV 205

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELSCQ+YQRS DMGLGVPFNIASYALLT MIAHV  L PGDFVH +GDAH+Y NH+ P
Sbjct: 206 NGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHVTGLQPGDFVHTLGDAHIYLNHIEP 265

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           L+ QL   P+PFP LKI  + + ID F A DF+L GYNPH
Sbjct: 266 LKTQLQREPRPFPKLKIVRKVEAIDDFTADDFRLEGYNPH 305


>M3ZJ50_XIPMA (tr|M3ZJ50) Thymidylate synthase OS=Xiphophorus maculatus GN=TYMS
           PE=3 SV=1
          Length = 321

 Score =  387 bits (995), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 178/276 (64%), Positives = 211/276 (76%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L + I+              LS FG Q+R+NLR  FPLLTTK+VFW+G++EEL
Sbjct: 37  DERGYLSLAEYIMEHGCKKGDRTGTGVLSLFGAQVRYNLRDQFPLLTTKRVFWKGILEEL 96

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWFI GSTNAK L EKG+ IWD N SR++LD++G TEREEGDLGPVYGFQWRHFGA Y D
Sbjct: 97  LWFIKGSTNAKELSEKGVKIWDANGSRDFLDNLGFTEREEGDLGPVYGFQWRHFGAEYKD 156

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DY+GQG DQL ++I+ IK NP DRRII+ AWNP DL +MALPPCH   QF+V +GEL
Sbjct: 157 MHTDYTGQGVDQLQNIIDTIKKNPEDRRIIMCAWNPKDLPIMALPPCHALCQFYVCDGEL 216

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQ+YQRSADMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAHVY NHV PL+ Q
Sbjct: 217 SCQLYQRSADMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHVYLNHVEPLKVQ 276

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           +    +PFPTLKI  + + I+ F A DF++ GYNPH
Sbjct: 277 VQREIRPFPTLKIKRKVESINDFQAEDFEICGYNPH 312


>B0WW05_CULQU (tr|B0WW05) Thymidylate synthase OS=Culex quinquefasciatus
           GN=CpipJ_CPIJ011359 PE=3 SV=1
          Length = 310

 Score =  387 bits (994), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 183/280 (65%), Positives = 211/280 (75%), Gaps = 1/280 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR-SFPLLTTKKVFWRGV 302
           Q  +E  YL L + II++            LS FG QMR+NLR  + PLLTTK+VF+RGV
Sbjct: 22  QNEDEMQYLELTRRIIAKGNKRLDRTGVGTLSIFGSQMRYNLRNNTLPLLTTKRVFFRGV 81

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
            EELLWFI G TNAK LQ+K IHIWDGN++RE+LDS G T+REEGDLGPVYGFQWRHFGA
Sbjct: 82  AEELLWFIRGRTNAKDLQQKNIHIWDGNSTREFLDSAGFTDREEGDLGPVYGFQWRHFGA 141

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
           +Y     DY+G+G DQL +VIN+IK NP DRRII+SAWNPVD+  MALPPCH  AQFFV+
Sbjct: 142 KYKTCDDDYTGEGIDQLAEVINRIKTNPTDRRIIMSAWNPVDIPQMALPPCHCLAQFFVS 201

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           +GELSCQ+YQRSADMGLGVPFNIASYALLT MIAHV  L PGDFVH  GD HVY NHV P
Sbjct: 202 DGELSCQLYQRSADMGLGVPFNIASYALLTHMIAHVTGLQPGDFVHTTGDTHVYLNHVEP 261

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           LQ QL+  PKPFPTL      + ID F   DF + GY+P+
Sbjct: 262 LQAQLMRKPKPFPTLHFKRVVQSIDDFQFEDFDVRGYDPY 301


>Q27551_CRYPV (tr|Q27551) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Cryptosporidium parvum GN=DHFR-TS
           PE=3 SV=1
          Length = 499

 Score =  386 bits (991), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 214/502 (42%), Positives = 284/502 (56%), Gaps = 33/502 (6%)

Query: 30  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 89
           VV A+    GIG +G+LPW +  DLKFF +IT+   D  KKNA++MGRKTW+SI    RP
Sbjct: 9   VVAASVLSRGIGINGQLPWSISEDLKFFSKITSNNCDSNKKNALIMGRKTWDSI--GRRP 66

Query: 90  LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 149
           L  R  VV++ S   D     NV++  ++              +IE +FV GG  I+R+ 
Sbjct: 67  LKNRKIVVISSSLPQDEADP-NVIVFRNLEDSIKNLMNDD---TIENIFVCGGESIYRDA 122

Query: 150 LNAPGCEAIHFTEIH-ASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSS 208
           L     + I+ T +    IE DT+ P +  T   ++ S     +N I Y F  + + +  
Sbjct: 123 LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKN-ISYDFMVFEKQEKK 181

Query: 209 AAESLSQNTDPL------FDNNSDSL-------------KFEVQNFDFLPEMILQR-HEE 248
                 QN DP+       D+  D L             KF  +     P +   R H E
Sbjct: 182 TL----QNCDPVRGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYE 237

Query: 249 YMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLW 308
           + YL L+  ++               S FG  MRF++R SFPLLTTKKV  R + EEL+W
Sbjct: 238 FQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIW 297

Query: 309 FISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMH 368
           FI G TN   L EK ++IW GN S+EYL+ IGL  REE DLGP+YGFQWRH+   Y  MH
Sbjct: 298 FIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMH 357

Query: 369 KDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE-LS 427
            DY+G G DQL  +I  +K+NP DRR IL+AWNP  L  MALPPCH+ +Q++V N   LS
Sbjct: 358 DDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLS 417

Query: 428 CQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQL 487
           C +YQRS D+GLG PFNIASYA+LT M+A VC   PG+    IGDAH+Y NH+  L+EQL
Sbjct: 418 CNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQL 477

Query: 488 LNLPKPFPTLKINSEKKDIDSF 509
              P+PFP LK   + ++I+ F
Sbjct: 478 SRTPRPFPQLKFKRKVENIEDF 499


>Q544L2_MOUSE (tr|Q544L2) Thymidylate synthase OS=Mus musculus GN=Tyms PE=2 SV=1
          Length = 307

 Score =  385 bits (989), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 178/278 (64%), Positives = 207/278 (74%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           RH E  YLR ++ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+E
Sbjct: 21  RHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWFI GSTNAK L  KG+ IWD N SR++LDS+G + R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81  ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 140

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
            DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NG
Sbjct: 141 KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNG 200

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+
Sbjct: 201 ELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLK 260

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            QL   P+PFP LKI  + + ID F   DF++ GYNPH
Sbjct: 261 IQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPH 298


>H2M5Y9_ORYLA (tr|H2M5Y9) Uncharacterized protein OS=Oryzias latipes
           GN=LOC101158062 PE=3 SV=1
          Length = 320

 Score =  384 bits (987), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 175/276 (63%), Positives = 209/276 (75%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L++ I+              LS FG Q+R++LR  FPLLTTK+VFW+G++EEL
Sbjct: 36  DERGYLDLVKHILQNGRRKGDRTGTGVLSVFGAQVRYSLRDQFPLLTTKRVFWKGILEEL 95

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWFI GST+AK L +KG+ IWD N SR +LD++G T+REEGDLGPVYGFQWRHFGA Y D
Sbjct: 96  LWFIKGSTSAKELSDKGVKIWDANGSRAFLDNLGFTDREEGDLGPVYGFQWRHFGAEYKD 155

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DY+G+G DQL ++I+ IK NP DRRII+ AWNP DL LMALPPCH   QF+V +GEL
Sbjct: 156 MHTDYTGKGVDQLQNIIDTIKKNPEDRRIIMCAWNPKDLPLMALPPCHALCQFYVCDGEL 215

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQ+YQRSADMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAHVY NH  PLQEQ
Sbjct: 216 SCQLYQRSADMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHVYVNHAEPLQEQ 275

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           L    +PFP LKI     +ID F A DF++ GY+PH
Sbjct: 276 LQRDVRPFPKLKIKRTVANIDDFTAEDFEICGYSPH 311


>K7J2H1_NASVI (tr|K7J2H1) Thymidylate synthase OS=Nasonia vitripennis PE=3 SV=1
          Length = 316

 Score =  384 bits (986), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 177/275 (64%), Positives = 211/275 (76%), Gaps = 1/275 (0%)

Query: 251 YLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR-SFPLLTTKKVFWRGVVEELLWF 309
           YL+LI+ I+ +             S FG QMRF+LR  + PLLTTK+VFWR V EEL WF
Sbjct: 35  YLKLIRLILDKGAVKDDRTGVGTHSVFGTQMRFSLRDGTLPLLTTKRVFWRAVAEELFWF 94

Query: 310 ISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHK 369
           I GSTNAK L  KG+ IWD NASRE+LD+ G  +REEGDLGPVYGFQWRHFGA+Y DMH 
Sbjct: 95  IRGSTNAKELSAKGVKIWDANASREFLDTCGFQDREEGDLGPVYGFQWRHFGAKYVDMHT 154

Query: 370 DYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQ 429
           DYSGQG+DQL DVI+K+K+NP+DRRII+SAWNPVD+  MALPPCH  AQF+V +GELSC 
Sbjct: 155 DYSGQGFDQLADVIDKVKNNPDDRRIIMSAWNPVDIPKMALPPCHSLAQFYVYDGELSCH 214

Query: 430 MYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLN 489
           +YQR+ DMGLGVPFNIASY+LLT MIAHV  L PG+FVH +GD HVY NHV  ++EQ+  
Sbjct: 215 LYQRAGDMGLGVPFNIASYSLLTIMIAHVANLKPGEFVHTMGDTHVYRNHVDAVKEQIKR 274

Query: 490 LPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
            P+PFP L+I  +  DID F  +DF+L GYNPH K
Sbjct: 275 EPRPFPKLRIKRQVTDIDDFQFSDFELEGYNPHPK 309


>Q6P045_DANRE (tr|Q6P045) Thymidylate synthase OS=Danio rerio GN=tyms PE=2 SV=1
          Length = 318

 Score =  384 bits (986), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 174/276 (63%), Positives = 208/276 (75%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L++ I+              +S FG Q R++LR  FPLLTTK+VFW+G++EEL
Sbjct: 34  DERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEEL 93

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWFI GSTNAK L EKG+ IWD N SRE+LD  G T+REEGDLGPVYGFQWRHFGA Y D
Sbjct: 94  LWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKD 153

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DYSG+G DQL  VI+ IK NP DRRII+ AWNP DL LMALPPCH   QF+V+NGEL
Sbjct: 154 MHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPLMALPPCHALCQFYVSNGEL 213

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQ+YQRS D+GLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+EQ
Sbjct: 214 SCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYTNHIEPLKEQ 273

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           +   P+PFP L+I  + + I+ F A DF++  YNPH
Sbjct: 274 IQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYNPH 309


>H0XYX0_OTOGA (tr|H0XYX0) Uncharacterized protein OS=Otolemur garnettii GN=TYMS
           PE=3 SV=1
          Length = 313

 Score =  383 bits (984), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 180/277 (64%), Positives = 207/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIEHILRCGFRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G ++REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSKREEGDLGPVYGFQWRHFGAEYK 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NGE
Sbjct: 148 DMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASY+LLT MIAH+  L PGDFVH +GDAH+Y NHV PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHITGLKPGDFVHTLGDAHIYLNHVEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DFK+ GYNPH
Sbjct: 268 QLQREPRPFPKLKILRKVETIDDFKAEDFKIEGYNPH 304


>Q8VDV6_MOUSE (tr|Q8VDV6) Tyms protein OS=Mus musculus GN=Tyms PE=2 SV=1
          Length = 307

 Score =  383 bits (984), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 177/278 (63%), Positives = 207/278 (74%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           +H E  YLR ++ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+E
Sbjct: 21  QHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWFI GSTNAK L  KG+ IWD N SR++LDS+G + R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81  ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 140

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
            DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NG
Sbjct: 141 KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNG 200

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+
Sbjct: 201 ELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLK 260

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            QL   P+PFP LKI  + + ID F   DF++ GYNPH
Sbjct: 261 IQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPH 298


>G1TZX9_RABIT (tr|G1TZX9) Thymidylate synthase (Fragment) OS=Oryctolagus
           cuniculus GN=LOC100347408 PE=3 SV=1
          Length = 308

 Score =  383 bits (984), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 180/277 (64%), Positives = 206/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 23  HGELQYLGQIEHILRCGFRKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 82

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD NASR++LDS+G + R+EGDLGPVYGFQWRHFGA Y 
Sbjct: 83  LLWFIKGSTNAKELSSKGVKIWDANASRDFLDSLGFSTRQEGDLGPVYGFQWRHFGAEYK 142

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           D   DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NGE
Sbjct: 143 DKDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGE 202

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAHV  L PGDFVH +GDAH+Y NH+ PL+ 
Sbjct: 203 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHVTGLKPGDFVHTLGDAHIYLNHIEPLKT 262

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF+L GYNPH
Sbjct: 263 QLQREPRPFPKLKILRKVETIDDFKAEDFQLEGYNPH 299


>F6TRC0_HORSE (tr|F6TRC0) Uncharacterized protein OS=Equus caballus GN=TYMS PE=3
           SV=1
          Length = 312

 Score =  383 bits (984), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 181/277 (65%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R+NLR  FPLLTTK+VFW+GV+EE
Sbjct: 27  HGELQYLGQIEHILRSGFRKEDRTGTGTLSVFGLQARYNLRDEFPLLTTKRVFWKGVLEE 86

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNA  L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 87  LLWFIKGSTNANELSCKGVKIWDANGSRDFLDSLGFSAREEGDLGPVYGFQWRHFGAEYK 146

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VIN IK NP+DRRIIL AWNP DL LMALPPCH   QF+V NGE
Sbjct: 147 DMDSDYSGQGVDQLQKVINTIKTNPDDRRIILCAWNPKDLPLMALPPCHALCQFYVVNGE 206

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+ 
Sbjct: 207 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIDPLKT 266

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF+L GY+PH
Sbjct: 267 QLQREPRPFPKLKILRKVETIDDFKAEDFQLEGYHPH 303


>G1SVL8_RABIT (tr|G1SVL8) Uncharacterized protein OS=Oryctolagus cuniculus
           GN=LOC100347408 PE=3 SV=1
          Length = 310

 Score =  383 bits (984), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 180/277 (64%), Positives = 206/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 25  HGELQYLGQIEHILRCGFRKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 84

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD NASR++LDS+G + R+EGDLGPVYGFQWRHFGA Y 
Sbjct: 85  LLWFIKGSTNAKELSSKGVKIWDANASRDFLDSLGFSTRQEGDLGPVYGFQWRHFGAEYK 144

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           D   DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NGE
Sbjct: 145 DKDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGE 204

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAHV  L PGDFVH +GDAH+Y NH+ PL+ 
Sbjct: 205 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHVTGLKPGDFVHTLGDAHIYLNHIEPLKT 264

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF+L GYNPH
Sbjct: 265 QLQREPRPFPKLKILRKVETIDDFKAEDFQLEGYNPH 301


>Q06BX0_9CILI (tr|Q06BX0) Dihydrofolate reductase-thymidylate synthase (Fragment)
           OS=Paramecium biaurelia PE=3 SV=1
          Length = 369

 Score =  383 bits (983), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 192/386 (49%), Positives = 246/386 (63%), Gaps = 30/386 (7%)

Query: 130 YCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP 189
           Y  S +K+F+IGG +IF E L    C  +H T I    +CD ++     + +++  +S  
Sbjct: 14  YNTSNQKMFLIGGKRIFEEGLATDKCSDVHLTRIGVETKCDVYLNKNIFSTFKVNKTSQT 73

Query: 190 KVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEY 249
           K EN+I Y +                    L + NS    +           I + H+E 
Sbjct: 74  KSENEINYDYQ------------------HLINKNSQEQSY-----------IDEEHQEN 104

Query: 250 MYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWF 309
            YL +I++I+ E            +S FG  MRFNL  SFPLLTTKKVF+RGVVEELLWF
Sbjct: 105 QYLDMIRKIMKEGVHKDDRTGVGTISIFGQTMRFNLAESFPLLTTKKVFFRGVVEELLWF 164

Query: 310 ISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHK 369
           + G TN K+L +KG+ IW+GN +REYLDSIGL+ R+E DLGPVYG+QWRHFGA Y D   
Sbjct: 165 LRGDTNGKILLDKGVKIWEGNGTREYLDSIGLSNRQEHDLGPVYGYQWRHFGAEYKDCQS 224

Query: 370 DYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQ 429
           DY+ QG DQ+ +VI  +K+NP+ RRIILSAWNP DLK MALPPCH+ +QFFVANG+LSC 
Sbjct: 225 DYNNQGVDQVKEVIQLLKNNPDSRRIILSAWNPSDLKQMALPPCHVMSQFFVANGKLSCM 284

Query: 430 MYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLN 489
           MYQRS D GLG+PFNIASYALLT M+A  C L  G+FVHV+GD H+Y NHV  L+ Q+  
Sbjct: 285 MYQRSCDFGLGIPFNIASYALLTQMLAKECNLNLGEFVHVLGDTHIYSNHVDALKRQIER 344

Query: 490 LPKPFPTLKINSEKKDIDSFVAADFK 515
           +P PFP LKI S+K   D +   DF+
Sbjct: 345 VPYPFPILKIKSKKSLFD-YTYEDFE 369


>F7GTE7_CALJA (tr|F7GTE7) Uncharacterized protein OS=Callithrix jacchus GN=TYMS
           PE=3 SV=1
          Length = 313

 Score =  383 bits (983), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 180/277 (64%), Positives = 206/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSAREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NGE
Sbjct: 148 DMDSDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNGE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DFK+ GYNPH
Sbjct: 268 QLQREPRPFPKLKILRKVEKIDDFKAEDFKVEGYNPH 304


>Q7ZUI7_DANRE (tr|Q7ZUI7) Tyms protein OS=Danio rerio GN=tyms PE=2 SV=1
          Length = 319

 Score =  382 bits (982), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 173/276 (62%), Positives = 208/276 (75%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L++ I+              +S FG Q R++LR  FPLLTTK+VFW+G++EEL
Sbjct: 35  DERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEEL 94

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWFI GSTNAK L EKG+ IWD N SRE+LD  G T+REEGDLGPVYGFQWRHFGA Y D
Sbjct: 95  LWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKD 154

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DYSG+G DQL  VI+ IK NP DRRII+ AWNP DL LMALPPCH   QF+V+NGEL
Sbjct: 155 MHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPLMALPPCHALCQFYVSNGEL 214

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQ+YQRS D+GLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+EQ
Sbjct: 215 SCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYTNHIEPLKEQ 274

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           +   P+PFP L+I  + + I+ F A DF++  Y+PH
Sbjct: 275 IQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYDPH 310


>Q9DGH5_DANRE (tr|Q9DGH5) Thymidylate synthase OS=Danio rerio GN=tyms PE=2 SV=1
          Length = 319

 Score =  382 bits (981), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 173/276 (62%), Positives = 208/276 (75%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L++ I+              +S FG Q R++LR  FPLLTTK+VFW+G++EEL
Sbjct: 35  DERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEEL 94

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWFI GSTNAK L EKG+ IWD N SRE+LD  G T+REEGDLGPVYGFQWRHFGA Y D
Sbjct: 95  LWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKD 154

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DYSG+G DQL  VI+ IK NP DRRII+ AWNP DL LMALPPCH   QF+V+NGEL
Sbjct: 155 MHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPLMALPPCHALCQFYVSNGEL 214

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQ+YQRS D+GLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+EQ
Sbjct: 215 SCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYTNHIEPLKEQ 274

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           +   P+PFP L+I  + + I+ F A DF++  Y+PH
Sbjct: 275 IQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYDPH 310


>E3XAX1_ANODA (tr|E3XAX1) Uncharacterized protein OS=Anopheles darlingi
           GN=AND_18288 PE=3 SV=1
          Length = 295

 Score =  382 bits (981), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 178/280 (63%), Positives = 215/280 (76%), Gaps = 1/280 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR-SFPLLTTKKVFWRGV 302
           +  +E  YL+LI++I+S+            LS FG Q+R++LR  +FPLLTTKKVF+RG+
Sbjct: 7   ENKDEQGYLQLIRDIVSKGNKRSDRTGVGTLSIFGTQLRYSLRDGTFPLLTTKKVFFRGI 66

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
            EELLWFI GSTNAK LQ KG+ IWDGN++RE+LDS G T+REEGDLGPVYGFQWRHFGA
Sbjct: 67  AEELLWFIRGSTNAKELQAKGVRIWDGNSTREFLDSCGFTDREEGDLGPVYGFQWRHFGA 126

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y   H DY+G+G DQL ++I+K+K+NP DRRIILSAWNPVD+ +MALPPCH   QF+VA
Sbjct: 127 TYGTCHDDYTGKGKDQLAEIIDKLKNNPTDRRIILSAWNPVDIPIMALPPCHCLVQFYVA 186

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELSCQMYQRSAD+GLGVPFNIASY+LLT MIAHV  L  G+F+H +GD H+Y NHV  
Sbjct: 187 NGELSCQMYQRSADVGLGVPFNIASYSLLTHMIAHVTGLKAGEFIHTMGDTHIYLNHVDA 246

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           L+EQL   PKPFPTL I  +   ID F   DF +  YNPH
Sbjct: 247 LKEQLQREPKPFPTLTIKRQVASIDDFQYEDFAINDYNPH 286


>Q9D0H1_MOUSE (tr|Q9D0H1) Putative uncharacterized protein OS=Mus musculus
           GN=Tyms PE=2 SV=1
          Length = 307

 Score =  382 bits (981), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 177/278 (63%), Positives = 206/278 (74%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           RH E  YLR ++ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+E
Sbjct: 21  RHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWFI GSTNAK L  KG+ IWD N SR++LDS+G + R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81  ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 140

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
            DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NG
Sbjct: 141 KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNG 200

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+
Sbjct: 201 ELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLK 260

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            QL   P+PF  LKI  + + ID F   DF++ GYNPH
Sbjct: 261 IQLQREPRPFQKLKILRKVETIDDFKVEDFQIEGYNPH 298


>Q16JK1_AEDAE (tr|Q16JK1) AAEL013305-PA OS=Aedes aegypti GN=AAEL013305 PE=3 SV=1
          Length = 313

 Score =  381 bits (978), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 178/277 (64%), Positives = 210/277 (75%), Gaps = 1/277 (0%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVEE 305
           EE  YL  IQ II              LS FG QMR++LR +  PLLTTK+VF+RGV EE
Sbjct: 28  EEMQYLEAIQRIIDTGDKRVDRTGVGTLSIFGTQMRYSLRDNVIPLLTTKRVFFRGVAEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK LQ K +HIWDGN++RE+LD+ G T+R+EGDLGPVYGFQWRHFGA+Y 
Sbjct: 88  LLWFIRGSTNAKDLQAKNVHIWDGNSTREFLDASGFTDRDEGDLGPVYGFQWRHFGAKYK 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
             + DY+GQG DQL +VIN+IK NP DRRII+SAWNP+D+  MALPPCH  AQFFVANGE
Sbjct: 148 TCNDDYTGQGIDQLAEVINRIKTNPTDRRIIMSAWNPIDIPQMALPPCHCLAQFFVANGE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRSADMGLGVPFNIASYALLT M+AHV  L  G+F+H  GD HVY NHV PL+E
Sbjct: 208 LSCQLYQRSADMGLGVPFNIASYALLTHMMAHVTGLKAGEFIHTTGDTHVYLNHVEPLKE 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL  +PK FPTL+     + ID F   DF++ GY+P+
Sbjct: 268 QLQRVPKRFPTLQFKRHVQSIDEFEMGDFEVCGYDPY 304


>Q06BX2_9CILI (tr|Q06BX2) Dihydrofolate reductase-thymidylate synthase (Fragment)
           OS=Paramecium biaurelia PE=3 SV=1
          Length = 369

 Score =  380 bits (977), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 188/378 (49%), Positives = 242/378 (64%), Gaps = 29/378 (7%)

Query: 130 YCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP 189
           Y  S +K+F+IGG +IF E L    C  +H T I    +CD ++     + +++  +S  
Sbjct: 14  YNTSNQKMFLIGGKRIFEEGLATDKCSDVHLTRIGVETKCDVYLNKNIFSTFKVNKTSQT 73

Query: 190 KVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEY 249
           K EN+I Y +                    L + NS    +           I + H+E 
Sbjct: 74  KSENEINYDYQ------------------HLINKNSQEQSY-----------IDEEHQEN 104

Query: 250 MYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEELLWF 309
            YL +I++I+ E            +S FG  MRFNL  SFPLLTTKKVF+RG VEELLWF
Sbjct: 105 QYLDMIRKIMKEGVHKDDRTGVGTISIFGQTMRFNLAESFPLLTTKKVFFRGAVEELLWF 164

Query: 310 ISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSDMHK 369
           + G TN K+L +KG+ IW+GN +REYLDSIGL+ R+E DLGPVYG+QWRHFGA Y D   
Sbjct: 165 LRGDTNGKILLDKGVKIWEGNGTREYLDSIGLSNRQEHDLGPVYGYQWRHFGAEYKDCQS 224

Query: 370 DYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGELSCQ 429
           DY+ QG DQ+ +VI  +K+NP+ RRIILSAWNP DL+ MALPPCH+ +QFFVANG+LSC 
Sbjct: 225 DYNNQGVDQVKEVIQLLKNNPDSRRIILSAWNPSDLEQMALPPCHVMSQFFVANGKLSCM 284

Query: 430 MYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQLLN 489
           MYQRS D+GLG+PFNIASYALLT M+A  C L  G+FVHV+GD H+Y NHV  L+ Q+  
Sbjct: 285 MYQRSCDLGLGIPFNIASYALLTQMLAKECNLNLGEFVHVLGDTHIYSNHVDALKRQIER 344

Query: 490 LPKPFPTLKINSEKKDID 507
           +P PFP LKI S+K   D
Sbjct: 345 VPYPFPILKIKSQKSLFD 362


>G3IFY1_CRIGR (tr|G3IFY1) Thymidylate synthase OS=Cricetulus griseus
           GN=I79_022656 PE=3 SV=1
          Length = 307

 Score =  380 bits (977), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 177/278 (63%), Positives = 206/278 (74%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           RH E  YL  ++ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+E
Sbjct: 21  RHGELQYLGQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWFI GSTNAK L  KG+ IWD N SR++LDS+G + R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81  ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADY 140

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
            DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NG
Sbjct: 141 KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVENG 200

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+
Sbjct: 201 ELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEPLK 260

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            QL   P+PFP LKI  + + ID F   DF++ GYNPH
Sbjct: 261 IQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPH 298


>G3TE40_LOXAF (tr|G3TE40) Thymidylate synthase (Fragment) OS=Loxodonta africana
           GN=LOC100663392 PE=3 SV=1
          Length = 305

 Score =  380 bits (977), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 177/277 (63%), Positives = 206/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  IQ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 20  HGELQYLGQIQHILRCGVRKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 79

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA+Y 
Sbjct: 80  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSAREEGDLGPVYGFQWRHFGAKYK 139

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM+ DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL  MALPPCH   QF+V NGE
Sbjct: 140 DMNSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLAQMALPPCHALCQFYVVNGE 199

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASY+LLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+ 
Sbjct: 200 LSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEPLKV 259

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP L I  +   ID+F A DF++ GYNPH
Sbjct: 260 QLQREPRPFPKLNILRKVDTIDAFKAEDFQIEGYNPH 296


>I3JFM1_ORENI (tr|I3JFM1) Thymidylate synthase OS=Oreochromis niloticus
           GN=LOC100709669 PE=3 SV=1
          Length = 325

 Score =  380 bits (976), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 174/276 (63%), Positives = 208/276 (75%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L++ I+              LS FG Q+R++LR  FPLLTTK+VFWRG++EEL
Sbjct: 41  DEQGYLSLVEHILENGRLKGDRTNTGVLSLFGAQVRYSLRDQFPLLTTKRVFWRGILEEL 100

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWFI GSTN+K L EKG+ IWD N SR++LD++G T+REEGDLGPVYGFQWRHFGA Y+D
Sbjct: 101 LWFIRGSTNSKELSEKGVKIWDANGSRDFLDNLGFTDREEGDLGPVYGFQWRHFGAEYTD 160

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGEL 426
           MH DY+GQG DQL  VI+ IK NP DRRII+ AWNP DL  MALPPCH   QF+V +GEL
Sbjct: 161 MHADYTGQGVDQLQKVIDTIKTNPEDRRIIMCAWNPKDLPRMALPPCHALCQFYVCDGEL 220

Query: 427 SCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQEQ 486
           SCQ+YQRSADMGLGVPFNIASY+LLT MIAH+  L PGDFVH +GDAHVY NH  PL+EQ
Sbjct: 221 SCQLYQRSADMGLGVPFNIASYSLLTYMIAHITGLKPGDFVHTLGDAHVYLNHTEPLKEQ 280

Query: 487 LLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           L    +PFP L+I  + + ID F   DF++  YNPH
Sbjct: 281 LQREIRPFPKLRILRKVEKIDDFRTEDFEIYDYNPH 316


>E2B1J5_CAMFO (tr|E2B1J5) Thymidylate synthase OS=Camponotus floridanus
           GN=EAG_01925 PE=3 SV=1
          Length = 298

 Score =  380 bits (976), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 177/282 (62%), Positives = 214/282 (75%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           + H+EY YLRL++++I               S FG Q+RF+LR   FPLLTTK+VFWR V
Sbjct: 10  EEHDEYQYLRLVEKVIRTGAKRNNRTGVDTYSIFGTQIRFSLRDGVFPLLTTKRVFWRAV 69

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           VEELLWFI GSTN+K L +KG+HIWD N SR +LDS G T+REEGDLGPVYGFQWRHFGA
Sbjct: 70  VEELLWFIKGSTNSKELSDKGVHIWDENGSRAFLDSCGFTDREEGDLGPVYGFQWRHFGA 129

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y D+  DY+GQG DQL +VI+KIKH P+DRRII+S WNPVD+  MALPPCH+  QF+V 
Sbjct: 130 EYKDIRTDYTGQGIDQLKEVIHKIKHCPDDRRIIMSNWNPVDIPEMALPPCHVLVQFYVN 189

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
           NGELS Q+YQRSAD+GLGVPFNIASY+LLT MIAHV  L PG+FVH +GD HVY NH+  
Sbjct: 190 NGELSAQLYQRSADIGLGVPFNIASYSLLTYMIAHVTGLKPGEFVHTMGDCHVYVNHISA 249

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           L+EQ+   P+ FP L+I  E K+ID FVA D +L+ Y P+ K
Sbjct: 250 LEEQIKREPREFPKLRIVREIKNIDDFVAEDLELIDYKPYPK 291


>D7EIA1_TRICA (tr|D7EIA1) Putative uncharacterized protein OS=Tribolium castaneum
           GN=TcasGA2_TC004238 PE=3 SV=1
          Length = 313

 Score =  380 bits (975), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 179/282 (63%), Positives = 211/282 (74%), Gaps = 1/282 (0%)

Query: 244 QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGV 302
           + HEEY YL  I++I+ +            LS FG QMR++LR + FPLLTTK+VFWR V
Sbjct: 25  RNHEEYQYLSHIRQILEKGVQRMDRTRIGTLSIFGVQMRYSLRDNVFPLLTTKRVFWRAV 84

Query: 303 VEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 362
           VEELLWFI GSTN+  L+EK +HIWD N+SR +LDS+GL E EEGDLGP+YGFQWRHFGA
Sbjct: 85  VEELLWFIKGSTNSNDLKEKNVHIWDANSSRAFLDSVGLEEYEEGDLGPIYGFQWRHFGA 144

Query: 363 RYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVA 422
            Y  +  DY+ +G DQL  VI+ I+ NPNDRRII+SAWNP DL  MALPPCH  AQFFVA
Sbjct: 145 EYKGVQGDYTNEGVDQLARVIHTIRTNPNDRRIIMSAWNPKDLHKMALPPCHCLAQFFVA 204

Query: 423 NGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRP 482
            GELSC +YQR+ DMGLGVPFNIASYALLT MIAHV  L PG+F+H IGD+HVY NHV P
Sbjct: 205 EGELSCLLYQRAGDMGLGVPFNIASYALLTRMIAHVTGLKPGEFIHSIGDSHVYLNHVEP 264

Query: 483 LQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           ++EQL  +P+ FPTL I      ID F   DF+LVGYNPH K
Sbjct: 265 IKEQLTRVPRAFPTLNIKRPVSSIDDFTFEDFELVGYNPHPK 306


>F6ZR77_MACMU (tr|F6ZR77) Thymidylate synthase OS=Macaca mulatta GN=TYMS PE=2
           SV=1
          Length = 313

 Score =  379 bits (974), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 178/277 (64%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSAREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 148 DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF++ GYNPH
Sbjct: 268 QLQREPRPFPKLKILRKVEKIDDFKAEDFQIEGYNPH 304


>F1PU23_CANFA (tr|F1PU23) Uncharacterized protein OS=Canis familiaris GN=TYMS
           PE=3 SV=1
          Length = 314

 Score =  379 bits (974), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 175/277 (63%), Positives = 204/277 (73%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YLR ++ I+S             LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 29  HGELQYLRQVEHILSCGARKHDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 88

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  +G+ IWD N SR++LDS+G   REEGDLGP+YGFQWRHFGA Y 
Sbjct: 89  LLWFIKGSTNAKELSSRGVKIWDANGSRDFLDSLGFANREEGDLGPIYGFQWRHFGAEYK 148

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           D   DYSGQG DQL  VI+ IK NP+DRRIIL  WNP DL LMALPPCH   QF+V NGE
Sbjct: 149 DKDSDYSGQGVDQLQKVIDTIKTNPDDRRIILCGWNPKDLPLMALPPCHALCQFYVVNGE 208

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 209 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 268

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP L+I    + ID F A DF++ GYNPH
Sbjct: 269 QLQREPRPFPKLRILRRVEKIDDFKAEDFQIEGYNPH 305


>Q53Y97_HUMAN (tr|Q53Y97) Thymidylate synthase OS=Homo sapiens GN=TYMS PE=2 SV=1
          Length = 313

 Score =  379 bits (974), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 177/277 (63%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  IQ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 148 DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP L+I  + + ID F A DF++ GYNPH
Sbjct: 268 QLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304


>G2HEY4_PANTR (tr|G2HEY4) Thymidylate synthase OS=Pan troglodytes GN=TYMS PE=2
           SV=1
          Length = 313

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 177/277 (63%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 148 DMESDYSGQGVDQLQRVIDTIKSNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF++ GYNPH
Sbjct: 268 QLQREPRPFPKLKILRKVEKIDDFKAEDFQIEGYNPH 304


>B4KHK2_DROMO (tr|B4KHK2) GI10845 OS=Drosophila mojavensis GN=Dmoj\GI10845 PE=3
           SV=1
          Length = 310

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 182/302 (60%), Positives = 220/302 (72%), Gaps = 2/302 (0%)

Query: 225 SDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFN 284
            +    E +N +  P   L+  +E  YL LI+ II               S FG QMRFN
Sbjct: 2   DEECSLEKRNKENSPIEKLRNKDEEQYLDLIKRIIENGDERMDRTKVGTRSIFGAQMRFN 61

Query: 285 LRRSFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTER 344
           LR SFPLLTTK+VF+RGV EEL+WFI+G T+AK+LQEK IHIWDGN++RE+LD  G T+R
Sbjct: 62  LRDSFPLLTTKRVFFRGVAEELIWFIAGQTDAKILQEKNIHIWDGNSTREFLDKCGHTDR 121

Query: 345 EEGDLGPVYGFQWRHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVD 404
           E GDLGPVYGFQWRHFGA+Y     DY+GQG DQL  VI+ I+++P DRRII+SAWNP+D
Sbjct: 122 EVGDLGPVYGFQWRHFGAKYGKCTDDYTGQGIDQLKQVIDTIRNDPADRRIIMSAWNPLD 181

Query: 405 LKLMALPPCHMFAQFFVAN--GELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELV 462
           +  MALPPCH  AQF+V+   GELSCQ+YQRSADMGLGVPFNIASYALLT MIAHV  L 
Sbjct: 182 IPQMALPPCHCLAQFYVSQSRGELSCQLYQRSADMGLGVPFNIASYALLTYMIAHVTGLK 241

Query: 463 PGDFVHVIGDAHVYHNHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           PGDFVH +GDAHVY+NHV PL EQ+   P+PFP L    +  +I+ F   DF++VGYNP+
Sbjct: 242 PGDFVHTLGDAHVYNNHVNPLLEQMKREPRPFPKLVFKRQVTNIEDFRYEDFEIVGYNPY 301

Query: 523 QK 524
            K
Sbjct: 302 GK 303


>H2NVZ8_PONAB (tr|H2NVZ8) Uncharacterized protein (Fragment) OS=Pongo abelii
           GN=TYMS PE=3 SV=2
          Length = 338

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 177/277 (63%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 53  HGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 112

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 113 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 172

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 173 DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 232

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 233 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 292

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF++ GYNPH
Sbjct: 293 QLQREPRPFPKLKILRKVEKIDDFKAEDFQIEGYNPH 329


>A8K9A5_HUMAN (tr|A8K9A5) cDNA FLJ78114, highly similar to Homo sapiens
           thymidylate synthetase, mRNA OS=Homo sapiens PE=2 SV=1
          Length = 313

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 177/277 (63%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  IQ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 148 DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSRDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP L+I  + + ID F A DF++ GYNPH
Sbjct: 268 QLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304


>J3JUF8_9CUCU (tr|J3JUF8) Uncharacterized protein OS=Dendroctonus ponderosae PE=2
           SV=1
          Length = 320

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 174/280 (62%), Positives = 213/280 (76%), Gaps = 1/280 (0%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FPLLTTKKVFWRGVVE 304
           HEE+ YL  I+ I+ +             S FG QMR++LR + FPLLTTK+VFWR VVE
Sbjct: 34  HEEHQYLNHIKLILEKGVKTADRTGVGTYSIFGAQMRYSLRDNIFPLLTTKRVFWRAVVE 93

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWFI GSTNA  L++K +HIWD N++RE+LDS+ L +REEGDLGP+YGFQWRHFGA Y
Sbjct: 94  ELLWFIRGSTNAFELKDKNVHIWDANSTREFLDSVSLKDREEGDLGPIYGFQWRHFGAEY 153

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
             M  DY  +G DQL  VIN I++ P DRR+I+ AWNPVD+  MALPPCH   QF+VANG
Sbjct: 154 KGMRADYKNKGIDQLAHVINTIRNKPTDRRMIMCAWNPVDIPEMALPPCHCLVQFYVANG 213

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRSADMGLGVPFNIASYALLT MIAH+  L PG+F+H +GD+HVY NHV PL+
Sbjct: 214 ELSCQLYQRSADMGLGVPFNIASYALLTYMIAHITNLQPGEFIHSLGDSHVYLNHVEPLK 273

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           EQ+   P+PFPTL+I  + + I+ F A DF++VGYNPH K
Sbjct: 274 EQIEREPRPFPTLQIKRKVETIEDFTAEDFEIVGYNPHPK 313


>K7EU16_PONAB (tr|K7EU16) Thymidylate synthase OS=Pongo abelii GN=TYMS PE=3 SV=1
          Length = 313

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 177/277 (63%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 148 DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP LKI  + + ID F A DF++ GYNPH
Sbjct: 268 QLQREPRPFPKLKILRKVEKIDDFKAEDFQIEGYNPH 304


>B4NXB1_DROYA (tr|B4NXB1) GE14974 OS=Drosophila yakuba GN=Dyak\GE14974 PE=3 SV=1
          Length = 321

 Score =  379 bits (972), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 176/280 (62%), Positives = 215/280 (76%), Gaps = 2/280 (0%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L+++II+             LS FG QMRF++R+SFPLLTTK+VF+R V EEL
Sbjct: 35  DEMQYLDLLRQIIANGEQRMDRTQVGTLSLFGSQMRFDMRQSFPLLTTKRVFFRAVAEEL 94

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWF++G T+AK+LQ K +HIWDGN++RE+LD +G TER  GDLGPVYGFQWRHFGA Y+ 
Sbjct: 95  LWFVAGKTDAKLLQAKNVHIWDGNSTREFLDKLGFTERAVGDLGPVYGFQWRHFGAEYAT 154

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN--G 424
              DYSG+G DQL  VI+ IK+NP+DRRII+SAWNP+D+  MALPPCH  AQF+V+   G
Sbjct: 155 CDDDYSGKGIDQLRQVIDTIKNNPSDRRIIMSAWNPLDIPKMALPPCHCLAQFYVSQTRG 214

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQ+YQRSADMGLGVPFNIASYALLT MIAHV  L PGDFVH +GD HVY NHV PL+
Sbjct: 215 ELSCQLYQRSADMGLGVPFNIASYALLTHMIAHVTGLKPGDFVHTMGDTHVYLNHVEPLK 274

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           EQL   P+PFP L I  + +DI+ F   DF++V YNP+ K
Sbjct: 275 EQLQRTPRPFPKLIIKRQVQDIEDFRFEDFEIVDYNPYPK 314


>B3RLB4_TRIAD (tr|B3RLB4) Putative uncharacterized protein OS=Trichoplax
           adhaerens GN=TRIADDRAFT_18453 PE=3 SV=1
          Length = 317

 Score =  379 bits (972), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 180/278 (64%), Positives = 205/278 (73%), Gaps = 1/278 (0%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFPLLTTKKVFWRGVVE 304
           HEEY YLRLIQ I++E             S FG QMRF+LR    PLLTTK+ FWRG+ E
Sbjct: 31  HEEYQYLRLIQRIMNEGNFKGDRTGTGTKSIFGAQMRFSLRDNQMPLLTTKRTFWRGIAE 90

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWF+ GSTNA  L EKGI  W+ N SRE+LDS GL ERE GDLGP+YGFQWRHFGA+Y
Sbjct: 91  ELLWFVKGSTNANQLNEKGIKFWNANGSREFLDSRGLHEREVGDLGPIYGFQWRHFGAKY 150

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
           ++MH DY+GQG DQL +VI+KIK +PNDRRIILSAWNP DL  MALPPCH F QF+V +G
Sbjct: 151 TNMHADYTGQGVDQLAEVIHKIKTSPNDRRIILSAWNPPDLPEMALPPCHAFVQFYVCDG 210

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
            LSCQ+YQRS DMGLGVPFNIASY+LLT MIAH+C+L   DFVH IGDAHVY NH   LQ
Sbjct: 211 RLSCQLYQRSGDMGLGVPFNIASYSLLTHMIAHICDLEAEDFVHTIGDAHVYLNHFDALQ 270

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           EQL+  PK FP L    +  DID F   DF+L  Y  H
Sbjct: 271 EQLMREPKKFPKLNFKRKISDIDDFKYEDFELQDYQFH 308


>C3ZXJ5_BRAFL (tr|C3ZXJ5) Putative uncharacterized protein OS=Branchiostoma
           floridae GN=BRAFLDRAFT_77468 PE=3 SV=1
          Length = 294

 Score =  378 bits (971), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 175/287 (60%), Positives = 210/287 (73%)

Query: 238 LPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKV 297
           +P    ++H+EY YL L++ I+              LS FG Q R++LR  FPLLTTK+V
Sbjct: 1   MPSRPARKHDEYQYLDLVRHILDCGQRKDDRTGTGTLSVFGAQCRYSLRGQFPLLTTKRV 60

Query: 298 FWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQW 357
           FWRGV EELLWF+ G TN K L +K +HIWD N SR++LD  GL+  EEGDLGPVYGFQW
Sbjct: 61  FWRGVAEELLWFVRGCTNGKELSDKKVHIWDANGSRDFLDKRGLSHYEEGDLGPVYGFQW 120

Query: 358 RHFGARYSDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFA 417
           RHFGA Y D + DY+GQG DQL  VI+ IK +P++RRII+SAWNP DL  MALPPCH F 
Sbjct: 121 RHFGAEYKDRYTDYTGQGVDQLAQVIHTIKTDPDNRRIIMSAWNPPDLPKMALPPCHAFV 180

Query: 418 QFFVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYH 477
           QF+V NGELSCQ+YQRS D GLGVPFNIASY+LLT MIAH+  L PGDFVH +GDAHVY 
Sbjct: 181 QFYVCNGELSCQLYQRSGDTGLGVPFNIASYSLLTYMIAHITGLKPGDFVHTLGDAHVYV 240

Query: 478 NHVRPLQEQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           NHV  L+EQL   P+PFPTL I  + ++ID F   DF++VGY PH K
Sbjct: 241 NHVDALKEQLKREPRPFPTLNIKRQVENIDDFKMEDFEIVGYKPHPK 287


>B4JCJ9_DROGR (tr|B4JCJ9) GH10649 OS=Drosophila grimshawi GN=Dgri\GH10649 PE=3
           SV=1
          Length = 329

 Score =  378 bits (971), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 177/280 (63%), Positives = 212/280 (75%), Gaps = 2/280 (0%)

Query: 247 EEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEEL 306
           +E  YL L++ II              LS FG QMRF+LR SFPLLTTK+VF+RGV EEL
Sbjct: 43  DEQQYLDLLKRIIKTGDQRIDRTAVGTLSIFGTQMRFDLRDSFPLLTTKRVFFRGVAEEL 102

Query: 307 LWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYSD 366
           LWF++G TNAK+LQ K +HIWD N++RE+LD  G T+R+EGDLGPVYGFQWRHFGA Y  
Sbjct: 103 LWFVAGKTNAKLLQAKKVHIWDFNSTREFLDKCGHTDRDEGDLGPVYGFQWRHFGAEYRG 162

Query: 367 MHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVAN--G 424
              DY+GQG DQL  VI+ I++NP DRRII+SAWNP+D+  MALPPCH   QFFV+   G
Sbjct: 163 CDDDYTGQGVDQLQQVIDTIRNNPADRRIIMSAWNPLDIPKMALPPCHCLVQFFVSQSRG 222

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQMYQRSADMGLGVPFNIASYALLT MIAHV  L PGDFVH +GD HVY NHV PLQ
Sbjct: 223 ELSCQMYQRSADMGLGVPFNIASYALLTYMIAHVTGLKPGDFVHTMGDTHVYLNHVEPLQ 282

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPHQK 524
           EQ+  +P+PFP L+I  + + I+ F   DF++V YNP++K
Sbjct: 283 EQMKRVPRPFPKLRIKRQVEKIEDFCYDDFEVVDYNPYEK 322


>Q53FB7_HUMAN (tr|Q53FB7) Thymidylate synthase (Fragment) OS=Homo sapiens PE=2
           SV=1
          Length = 313

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 176/277 (63%), Positives = 205/277 (74%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  IQ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V N E
Sbjct: 148 DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPF+IASYALLT MIAH+  L PGDF+H +GDAH+Y NH+ PL+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFDIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
           QL   P+PFP L+I  + + ID F A DF++ GYNPH
Sbjct: 268 QLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPH 304


>Q9E202_9ALPH (tr|Q9E202) Thymidylate synthetase OS=Cercopithecine herpesvirus 9
           PE=3 SV=1
          Length = 295

 Score =  377 bits (968), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 179/278 (64%), Positives = 203/278 (73%)

Query: 245 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVE 304
           +H EY YL  +  I+              LS FG Q R+NLR  FPLLTTK+VFW+GVVE
Sbjct: 9   KHSEYQYLEQVNFILHNGVQKTDRTGTGTLSVFGMQSRYNLRNEFPLLTTKRVFWKGVVE 68

Query: 305 ELLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARY 364
           ELLWFI GSTN+  L EKG+ IW  + S+++L S G   R+EGDLGPVYGFQWRHFGA Y
Sbjct: 69  ELLWFIKGSTNSTELVEKGVKIWSAHGSKQFLHSNGFDNRQEGDLGPVYGFQWRHFGAEY 128

Query: 365 SDMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANG 424
            DM+ +Y GQG DQL +VIN IK NPNDRRIIL AWN  D+ LMALPPCHM  QF+VAN 
Sbjct: 129 VDMNTNYFGQGVDQLQNVINLIKTNPNDRRIILCAWNAKDVPLMALPPCHMLCQFYVANN 188

Query: 425 ELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQ 484
           ELSCQMYQRSADMGLGVPFNIASYALLT MIAHV +L  GD VH IGDAH+Y NH+ PL+
Sbjct: 189 ELSCQMYQRSADMGLGVPFNIASYALLTYMIAHVTDLKTGDLVHTIGDAHIYLNHIEPLK 248

Query: 485 EQLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            QL   PK FPTL+I    KDI+ F A DF L GYNPH
Sbjct: 249 LQLTRQPKQFPTLRITRTVKDINDFKADDFVLEGYNPH 286


>F7GTH3_CALJA (tr|F7GTH3) Uncharacterized protein OS=Callithrix jacchus GN=TYMS
           PE=3 SV=1
          Length = 313

 Score =  377 bits (968), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 178/277 (64%), Positives = 204/277 (73%)

Query: 246 HEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFPLLTTKKVFWRGVVEE 305
           H E  YL  I+ I+              LS FG Q R++LR  FPLLTTK+VFW+GV+EE
Sbjct: 28  HGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87

Query: 306 LLWFISGSTNAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGARYS 365
           LLWFI GSTNAK L  KG+ IWD N SR++LDS+G + REEGDLGPVYGFQWRHFGA Y 
Sbjct: 88  LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSAREEGDLGPVYGFQWRHFGAEYR 147

Query: 366 DMHKDYSGQGYDQLLDVINKIKHNPNDRRIILSAWNPVDLKLMALPPCHMFAQFFVANGE 425
           DM  DYSGQG DQL  VI+ IK NP+DRRII+ AWNP DL LMALPPCH   QF+V NGE
Sbjct: 148 DMDSDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNGE 207

Query: 426 LSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCELVPGDFVHVIGDAHVYHNHVRPLQE 485
           LSCQ+YQRS DMGLGVPFNIASYALLT MIAH+  L PGDFVH +GDAH+Y NH+  L+ 
Sbjct: 208 LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEILKV 267

Query: 486 QLLNLPKPFPTLKINSEKKDIDSFVAADFKLVGYNPH 522
            L   P+PFP LKI  + + ID F A DFK+ GYNPH
Sbjct: 268 TLQREPRPFPKLKILRKVEKIDDFKAEDFKVEGYNPH 304