Miyakogusa Predicted Gene

Lj1g3v3381400.1
Show Alignment: 

BLASTP 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= Lj1g3v3381400.1 tr|I1K753|I1K753_SOYBN Bifunctional dihydrofolate
reductase-thymidylate synthase OS=Glycine max GN=G,82.29,0,seg,NULL;
Dihydrofolate reductase-like,Dihydrofolate reductase-like domain;
Thymidylate synthase/dCM,CUFF.30578.1
         (328 letters)

Database: trembl 
           41,451,118 sequences; 13,208,986,710 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

I1K754_SOYBN (tr|I1K754) Bifunctional dihydrofolate reductase-th...   473   e-131
I1K753_SOYBN (tr|I1K753) Bifunctional dihydrofolate reductase-th...   435   e-119
G7J766_MEDTR (tr|G7J766) Dihydrofolate reductase-thymidylate syn...   423   e-116
G7J765_MEDTR (tr|G7J765) Dihydrofolate reductase-thymidylate syn...   423   e-116
G7J767_MEDTR (tr|G7J767) Bifunctional dihydrofolate reductase-th...   423   e-116
K7KHI6_SOYBN (tr|K7KHI6) Bifunctional dihydrofolate reductase-th...   422   e-116
Q8L6F0_PEA (tr|Q8L6F0) Dihydrofolate reductase-thymidylate synth...   417   e-114
K7LP84_SOYBN (tr|K7LP84) Bifunctional dihydrofolate reductase-th...   407   e-111
K7LSY4_SOYBN (tr|K7LSY4) Bifunctional dihydrofolate reductase-th...   402   e-110
M5VK78_PRUPE (tr|M5VK78) Uncharacterized protein OS=Prunus persi...   398   e-108
I1LQ11_SOYBN (tr|I1LQ11) Bifunctional dihydrofolate reductase-th...   397   e-108
F6I0M2_VITVI (tr|F6I0M2) Putative uncharacterized protein OS=Vit...   392   e-107
B9H0T4_POPTR (tr|B9H0T4) Dihydrofolate reductase-thymidylate syn...   388   e-105
B0BLI5_LOTJA (tr|B0BLI5) CM0216.390.nc protein OS=Lotus japonicu...   377   e-102
M0ZJD1_SOLTU (tr|M0ZJD1) Bifunctional dihydrofolate reductase-th...   373   e-101
K4B3J6_SOLLC (tr|K4B3J6) Bifunctional dihydrofolate reductase-th...   372   e-101
B9RH79_RICCO (tr|B9RH79) Bifunctional dihydrofolate reductase-th...   372   e-101
Q39687_DAUCA (tr|Q39687) Dihydrofolate reductase-thymidylate syn...   370   e-100
G7JHF2_MEDTR (tr|G7JHF2) Bifunctional dihydrofolate reductase-th...   370   e-100
B9GCZ3_ORYSJ (tr|B9GCZ3) Putative uncharacterized protein OS=Ory...   369   1e-99
C5Y2E9_SORBI (tr|C5Y2E9) Putative uncharacterized protein Sb05g0...   365   1e-98
K3ZSB7_SETIT (tr|K3ZSB7) Bifunctional dihydrofolate reductase-th...   364   2e-98
K3ZSR0_SETIT (tr|K3ZSR0) Bifunctional dihydrofolate reductase-th...   364   3e-98
J3ND79_ORYBR (tr|J3ND79) Uncharacterized protein OS=Oryza brachy...   359   7e-97
B8BKI9_ORYSI (tr|B8BKI9) Putative uncharacterized protein OS=Ory...   359   7e-97
Q2R481_ORYSJ (tr|Q2R481) Bifunctional dihydrofolate reductase-th...   358   2e-96
K3ZI20_SETIT (tr|K3ZI20) Bifunctional dihydrofolate reductase-th...   358   2e-96
B9GAQ2_ORYSJ (tr|B9GAQ2) Putative uncharacterized protein OS=Ory...   358   2e-96
B6UD82_MAIZE (tr|B6UD82) Bifunctional dihydrofolate reductase-th...   357   4e-96
K7UAA2_MAIZE (tr|K7UAA2) Bifunctional dihydrofolate reductase-th...   357   4e-96
I1R077_ORYGL (tr|I1R077) Bifunctional dihydrofolate reductase-th...   357   4e-96
J3MF38_ORYBR (tr|J3MF38) Bifunctional dihydrofolate reductase-th...   357   4e-96
I1IIJ7_BRADI (tr|I1IIJ7) Bifunctional dihydrofolate reductase-th...   350   3e-94
M7YZH3_TRIUA (tr|M7YZH3) Putative bifunctional dihydrofolate red...   349   9e-94
B8BPG2_ORYSI (tr|B8BPG2) Putative uncharacterized protein OS=Ory...   344   2e-92
B7FA29_ORYSJ (tr|B7FA29) cDNA, clone: J100037K11, full insert se...   344   2e-92
R7WB22_AEGTA (tr|R7WB22) Putative bifunctional dihydrofolate red...   344   3e-92
F6H1I8_VITVI (tr|F6H1I8) Putative uncharacterized protein OS=Vit...   343   4e-92
I1R663_ORYGL (tr|I1R663) Bifunctional dihydrofolate reductase-th...   343   7e-92
B9R7Y4_RICCO (tr|B9R7Y4) Bifunctional dihydrofolate reductase-th...   340   5e-91
M0YHZ0_HORVD (tr|M0YHZ0) Bifunctional dihydrofolate reductase-th...   339   7e-91
D7L1V0_ARALL (tr|D7L1V0) Dihydrofolate reductase-thymidylate syn...   339   9e-91
F2DUZ4_HORVD (tr|F2DUZ4) Bifunctional dihydrofolate reductase-th...   338   1e-90
M4D9B9_BRARP (tr|M4D9B9) Bifunctional dihydrofolate reductase-th...   335   1e-89
R0HKJ0_9BRAS (tr|R0HKJ0) Uncharacterized protein (Fragment) OS=C...   333   4e-89
D7MEC7_ARALL (tr|D7MEC7) Predicted protein OS=Arabidopsis lyrata...   328   2e-87
R0F3G9_9BRAS (tr|R0F3G9) Uncharacterized protein OS=Capsella rub...   322   1e-85
K7TWH4_MAIZE (tr|K7TWH4) Uncharacterized protein OS=Zea mays GN=...   318   2e-84
M4D4Y6_BRARP (tr|M4D4Y6) Bifunctional dihydrofolate reductase-th...   315   1e-83
B9H4E7_POPTR (tr|B9H4E7) Dihydrofolate reductase-thymidylate syn...   307   3e-81
M4DMC9_BRARP (tr|M4DMC9) Bifunctional dihydrofolate reductase-th...   287   4e-75
M0S7X1_MUSAM (tr|M0S7X1) Uncharacterized protein OS=Musa acumina...   287   4e-75
B9H4E4_POPTR (tr|B9H4E4) Dihydrofolate reductase-thymidylate syn...   285   2e-74
R0FWL1_9BRAS (tr|R0FWL1) Uncharacterized protein OS=Capsella rub...   283   6e-74
Q9SIK4_ARATH (tr|Q9SIK4) Bifunctional dihydrofolate reductase-th...   282   1e-73
D7LBE8_ARALL (tr|D7LBE8) Predicted protein OS=Arabidopsis lyrata...   274   4e-71
D8SA97_SELML (tr|D8SA97) Putative uncharacterized protein OS=Sel...   260   4e-67
D8QVP4_SELML (tr|D8QVP4) Putative uncharacterized protein OS=Sel...   259   1e-66
M4C8Q3_BRARP (tr|M4C8Q3) Uncharacterized protein OS=Brassica rap...   257   5e-66
A9RXS0_PHYPA (tr|A9RXS0) Predicted protein OS=Physcomitrella pat...   233   1e-58
Q01FK1_OSTTA (tr|Q01FK1) Bifunctional dihydrofolate reductase-th...   222   1e-55
A4RXM1_OSTLU (tr|A4RXM1) Predicted protein OS=Ostreococcus lucim...   221   4e-55
B9HRK6_POPTR (tr|B9HRK6) Dihydrofolate reductase-thymidylate syn...   216   1e-53
I0YVC8_9CHLO (tr|I0YVC8) Bifunctional dihydrofolate reductase-th...   213   7e-53
E1ZCI9_CHLVA (tr|E1ZCI9) Putative uncharacterized protein OS=Chl...   212   2e-52
C1MMA6_MICPC (tr|C1MMA6) Bifunctional dihydrofolate reductase-th...   206   8e-51
C1E6F7_MICSR (tr|C1E6F7) Bifunctional dihydrofolate reductase-th...   197   4e-48
K8ECA8_9CHLO (tr|K8ECA8) Bifunctional dihydrofolate reductase-th...   191   3e-46
A8JD96_CHLRE (tr|A8JD96) Predicted protein OS=Chlamydomonas rein...   191   3e-46
D8UB22_VOLCA (tr|D8UB22) Putative uncharacterized protein OS=Vol...   182   1e-43
L1JGV3_GUITH (tr|L1JGV3) Bifunctional dihydrofolate reductase-th...   156   9e-36
D8LWN8_BLAHO (tr|D8LWN8) Thymidylate synthase OS=Blastocystis ho...   149   1e-33
K2CJT4_9BACT (tr|K2CJT4) Bifunctional dihydrofolate reductase-th...   147   4e-33
C3Z0P2_BRAFL (tr|C3Z0P2) Putative uncharacterized protein OS=Bra...   147   5e-33
R1BUZ9_EMIHU (tr|R1BUZ9) Uncharacterized protein OS=Emiliania hu...   147   5e-33
H8ZWN9_9EUKA (tr|H8ZWN9) Dihydrofolate reductase-thymidylate syn...   145   1e-32
G4YSZ0_PHYSP (tr|G4YSZ0) Putative uncharacterized protein OS=Phy...   145   2e-32
F0W9B4_9STRA (tr|F0W9B4) Bifunctional dihydrofolate reductasethy...   142   2e-31
R4G4F4_RHOPR (tr|R4G4F4) Putative dihydrofolate reductase OS=Rho...   142   2e-31
M4BX13_HYAAE (tr|M4BX13) Bifunctional dihydrofolate reductase-th...   141   3e-31
H3GWN7_PHYRM (tr|H3GWN7) Uncharacterized protein OS=Phytophthora...   140   7e-31
N6T381_9CUCU (tr|N6T381) Uncharacterized protein (Fragment) OS=D...   137   4e-30
F0YJX9_AURAN (tr|F0YJX9) Putative uncharacterized protein OS=Aur...   137   5e-30
J3JTN2_9CUCU (tr|J3JTN2) Uncharacterized protein OS=Dendroctonus...   136   1e-29
F2U1R1_SALS5 (tr|F2U1R1) Putative uncharacterized protein OS=Sal...   136   1e-29
A7SCT0_NEMVE (tr|A7SCT0) Predicted protein OS=Nematostella vecte...   135   2e-29
K1P8X7_CRAGI (tr|K1P8X7) Viral dihydrofolate reductase OS=Crasso...   134   4e-29
A8XF85_CAEBR (tr|A8XF85) Protein CBG12356 OS=Caenorhabditis brig...   133   7e-29
Q22KR8_TETTS (tr|Q22KR8) Bifunctional dihydrofolate reductase-th...   133   9e-29
D3PJE0_9MAXI (tr|D3PJE0) Dihydrofolate reductase OS=Lepeophtheir...   132   2e-28
I7IGH8_BABMI (tr|I7IGH8) Chromosome II, complete genome OS=Babes...   132   2e-28
E9AKW4_LEIMU (tr|E9AKW4) Dihydrofolate reductase-thymidylate syn...   131   4e-28
Q172I3_AEDAE (tr|Q172I3) AAEL007370-PA OS=Aedes aegypti GN=AAEL0...   130   5e-28
L7MJG0_9ACAR (tr|L7MJG0) Putative dihydrofolate reductase (Fragm...   130   8e-28
K7IQX8_NASVI (tr|K7IQX8) Uncharacterized protein OS=Nasonia vitr...   130   8e-28
M2Y9L6_GALSU (tr|M2Y9L6) Thymidylate synthase/dihydrofolate redu...   130   9e-28
C5LQI2_PERM5 (tr|C5LQI2) Dihydrofolate reductase-thymidylate syn...   129   1e-27
Q6BTR6_DEBHA (tr|Q6BTR6) DEHA2C16456p OS=Debaryomyces hansenii (...   129   1e-27
B9WKH7_CANDC (tr|B9WKH7) Dihydrofolate reductase, putative OS=Ca...   129   2e-27
J7GQW2_BOMMO (tr|J7GQW2) Dihydrofolate reductase OS=Bombyx mori ...   129   2e-27
Q6WEA6_HARCA (tr|Q6WEA6) Dihydrofolate reductase OS=Hartmannella...   129   2e-27
A4H4P8_LEIBR (tr|A4H4P8) Dihydrofolate reductase-thymidylate syn...   129   2e-27
C5MGL9_CANTT (tr|C5MGL9) Dihydrofolate reductase OS=Candida trop...   129   2e-27
C5KZ80_PERM5 (tr|C5KZ80) Dihydrofolate reductase/thymidilate syn...   128   2e-27
H9JUX7_BOMMO (tr|H9JUX7) Uncharacterized protein OS=Bombyx mori ...   128   2e-27
A3LSL9_PICST (tr|A3LSL9) Dihydrofolate reductase OS=Scheffersomy...   128   2e-27
Q5A5E0_CANAL (tr|Q5A5E0) Putative uncharacterized protein DFR1 O...   128   3e-27
G1UAH9_CANAX (tr|G1UAH9) Putative uncharacterized protein CaJ7.0...   128   3e-27
B4K681_DROMO (tr|B4K681) GI23507 OS=Drosophila mojavensis GN=Dmo...   127   4e-27
K0T9B5_THAOC (tr|K0T9B5) Uncharacterized protein OS=Thalassiosir...   127   4e-27
Q8MXB7_LEITR (tr|Q8MXB7) Dihydrofolate reductase-thymidylate syn...   127   5e-27
Q8MXB8_LEITR (tr|Q8MXB8) Dihydrofolate reductase-thymidylate syn...   127   5e-27
G0UQH6_TRYCI (tr|G0UQH6) Putative uncharacterized protein TCIL30...   127   6e-27
A5B4I5_VITVI (tr|A5B4I5) Putative uncharacterized protein OS=Vit...   127   6e-27
G0TZ26_TRYVY (tr|G0TZ26) Putative dihydrofolate reductase-thymid...   126   8e-27
Q6WEA4_HARCA (tr|Q6WEA4) Dihydrofolate reductase OS=Hartmannella...   126   1e-26
B7FQJ9_PHATC (tr|B7FQJ9) Predicted protein (Fragment) OS=Phaeoda...   126   1e-26
Q6WEA8_HARCA (tr|Q6WEA8) Dihydrofolate reductase OS=Hartmannella...   126   1e-26
B5YMV7_THAPS (tr|B5YMV7) Possible thymidylate synthase (Fragment...   125   2e-26
I1BWH0_RHIO9 (tr|I1BWH0) Dihydrofolate reductase OS=Rhizopus del...   125   3e-26
B4M4D4_DROVI (tr|B4M4D4) GJ10259 OS=Drosophila virilis GN=Dvir\G...   125   3e-26
H2XNW6_CIOIN (tr|H2XNW6) Uncharacterized protein OS=Ciona intest...   124   5e-26
A2BGQ1_DANRE (tr|A2BGQ1) Uncharacterized protein OS=Danio rerio ...   124   5e-26
C1C2C0_9MAXI (tr|C1C2C0) Dihydrofolate reductase OS=Caligus clem...   124   6e-26
Q6IQS4_DANRE (tr|Q6IQS4) Dihydrofolate reductase OS=Danio rerio ...   123   8e-26
H3IEF6_STRPU (tr|H3IEF6) Uncharacterized protein OS=Strongylocen...   123   8e-26
Q6WEA2_HARCA (tr|Q6WEA2) Dihydrofolate reductase OS=Hartmannella...   123   9e-26
B0X4N3_CULQU (tr|B0X4N3) Dihydrofolate reductase OS=Culex quinqu...   122   1e-25
Q8MQV3_LEIIN (tr|Q8MQV3) Bifunctional dihydrofolate reductase-th...   122   1e-25
Q8MQV1_LEICH (tr|Q8MQV1) Dhfr-ts OS=Leishmania chagasi PE=3 SV=1      122   1e-25
Q7Q0L5_ANOGA (tr|Q7Q0L5) AGAP010278-PA OS=Anopheles gambiae GN=A...   122   2e-25
H9HTP5_ATTCE (tr|H9HTP5) Uncharacterized protein OS=Atta cephalo...   121   3e-25
G8Y630_PICSO (tr|G8Y630) Piso0_004662 protein OS=Pichia sorbitop...   121   3e-25
Q98TR9_DANRE (tr|Q98TR9) Dihydrofolate reductase (Fragment) OS=D...   121   3e-25
R7Q5X1_CHOCR (tr|R7Q5X1) Bifunctional dihydrofolate reductase (D...   121   3e-25
H0XKH0_OTOGA (tr|H0XKH0) Uncharacterized protein OS=Otolemur gar...   121   4e-25
Q1LWC6_DANRE (tr|Q1LWC6) Novel protein similar to vertebrate dih...   120   5e-25
G3MHL1_9ACAR (tr|G3MHL1) Putative uncharacterized protein (Fragm...   120   5e-25
Q582G3_TRYB2 (tr|Q582G3) Bifunctional dihydrofolate reductase-th...   120   5e-25
C3KIX5_ANOFI (tr|C3KIX5) Dihydrofolate reductase OS=Anoplopoma f...   120   5e-25
Q8T5T9_TRYCR (tr|Q8T5T9) Dihydrofolate reductase-thymidylate syn...   120   5e-25
C9ZTK8_TRYB9 (tr|C9ZTK8) Dihydrofolate reductase-thymidylate syn...   120   5e-25
D3JL87_TRYCR (tr|D3JL87) Bifunctional dihydrofolate reductase-th...   120   6e-25
I6LEA0_TRYCR (tr|I6LEA0) Bifunctional dihydrofolate reductase-th...   120   6e-25
D3JLB1_TRYCR (tr|D3JLB1) Bifunctional dihydrofolate reductase-th...   120   6e-25
D3JLB2_TRYCR (tr|D3JLB2) Bifunctional dihydrofolate reductase-th...   120   6e-25
Q963S7_9TRYP (tr|Q963S7) Bifunctional dihydrofolate reductase-th...   120   6e-25
J4TW37_SACK1 (tr|J4TW37) DFR1-like protein OS=Saccharomyces kudr...   120   6e-25
H9AZH4_TRYCR (tr|H9AZH4) Bifunctional dihydrofolate reductase-th...   120   6e-25
D3JL83_TRYCR (tr|D3JL83) Bifunctional dihydrofolate reductase-th...   120   7e-25
D6CJT7_9BACT (tr|D6CJT7) Dihydrofolate reductase OS=uncultured b...   120   7e-25
B0BMV8_RAT (tr|B0BMV8) Dihydrofolate reductase OS=Rattus norvegi...   120   7e-25
Q296C6_DROPS (tr|Q296C6) GA13324 OS=Drosophila pseudoobscura pse...   120   7e-25
F1QRU7_DANRE (tr|F1QRU7) Uncharacterized protein OS=Danio rerio ...   120   7e-25
Q95NI3_TRYCR (tr|Q95NI3) Bifunctional dihydrofolate reductase-th...   120   7e-25
Q8T5T8_TRYCR (tr|Q8T5T8) Bifunctional dihydrofolate reductase-th...   120   7e-25
D3JLA1_TRYCR (tr|D3JLA1) Bifunctional dihydrofolate reductase-th...   120   7e-25
D3JL82_TRYCR (tr|D3JL82) Bifunctional dihydrofolate reductase-th...   120   7e-25
I6LEA8_TRYCR (tr|I6LEA8) Bifunctional dihydrofolate reductase-th...   120   8e-25
Q4DLS1_TRYCC (tr|Q4DLS1) Dihydrofolate reductase-thymidylate syn...   120   8e-25
D3JL86_TRYCR (tr|D3JL86) Bifunctional dihydrofolate reductase-th...   120   8e-25
E9B8U9_LEIDB (tr|E9B8U9) Dihydrofolate reductase-thymidylate syn...   120   9e-25
Q95NX3_TRYCR (tr|Q95NX3) Bifunctional dihydrofolate reductase-th...   120   1e-24
Q0IK63_TRYCR (tr|Q0IK63) Bifunctional dihydrofolate reductase-th...   120   1e-24
I6LEA6_TRYCR (tr|I6LEA6) Bifunctional dihydrofolate reductase-th...   120   1e-24
I6LEA1_TRYCR (tr|I6LEA1) Bifunctional dihydrofolate reductase-th...   120   1e-24
H9AZH1_TRYCR (tr|H9AZH1) Bifunctional dihydrofolate reductase-th...   120   1e-24
B3M2T2_DROAN (tr|B3M2T2) GF18503 OS=Drosophila ananassae GN=Dana...   120   1e-24
I6LEA2_TRYCR (tr|I6LEA2) Bifunctional dihydrofolate reductase-th...   120   1e-24
Q95NT2_TRYCR (tr|Q95NT2) Bifunctional dihydrofolate reductase-th...   120   1e-24
Q95NS0_TRYCR (tr|Q95NS0) Bifunctional dihydrofolate reductase-th...   120   1e-24
A9VA22_MONBE (tr|A9VA22) Predicted protein OS=Monosiga brevicoll...   120   1e-24
I6LEA3_TRYCR (tr|I6LEA3) Bifunctional dihydrofolate reductase-th...   120   1e-24
M3X0Q6_FELCA (tr|M3X0Q6) Uncharacterized protein (Fragment) OS=F...   119   1e-24
F6GYC9_VITVI (tr|F6GYC9) Putative uncharacterized protein OS=Vit...   119   1e-24
H9K575_APIME (tr|H9K575) Uncharacterized protein OS=Apis mellife...   119   1e-24
F6PUB9_HORSE (tr|F6PUB9) Uncharacterized protein OS=Equus caball...   119   1e-24
H0XQ29_OTOGA (tr|H0XQ29) Uncharacterized protein OS=Otolemur gar...   119   1e-24
I4DP20_PAPXU (tr|I4DP20) Dihydrofolate reductase (Fragment) OS=P...   119   1e-24
D3JL96_TRYCR (tr|D3JL96) Bifunctional dihydrofolate reductase-th...   119   1e-24
G1MB80_AILME (tr|G1MB80) Uncharacterized protein OS=Ailuropoda m...   119   1e-24
F7A9L9_MONDO (tr|F7A9L9) Uncharacterized protein OS=Monodelphis ...   119   1e-24
G0NUX7_CAEBE (tr|G0NUX7) Putative uncharacterized protein OS=Cae...   119   2e-24
H8XAD5_CANO9 (tr|H8XAD5) Dfr1 trimethoprim resistant dihydrofola...   119   2e-24
B4GFC1_DROPE (tr|B4GFC1) GL22182 OS=Drosophila persimilis GN=Dpe...   119   2e-24
Q2MH30_CRIGR (tr|Q2MH30) Dihydrofolate reductase OS=Cricetulus g...   119   2e-24
G9I0D7_9VIRU (tr|G9I0D7) Dihydrofolate reductase OS=Helicoverpa ...   119   2e-24
R7UK12_9ANNE (tr|R7UK12) Uncharacterized protein OS=Capitella te...   119   2e-24
Q8JKV3_9VIRU (tr|Q8JKV3) Dihydrofolate reductase OS=Heliothis ze...   119   2e-24
Q75BZ5_ASHGO (tr|Q75BZ5) ACR124Wp OS=Ashbya gossypii (strain ATC...   118   2e-24
H0H1D7_9SACH (tr|H0H1D7) Dfr1p OS=Saccharomyces cerevisiae x Sac...   118   2e-24
L9L4C5_TUPCH (tr|L9L4C5) Dihydrofolate reductase OS=Tupaia chine...   118   3e-24
M1VHU6_CYAME (tr|M1VHU6) Fusion protein of dihydrofolate reducta...   118   3e-24
E0W1C2_PEDHC (tr|E0W1C2) Dihydrofolate reductase, putative OS=Pe...   118   3e-24
F4X717_ACREC (tr|F4X717) Dihydrofolate reductase OS=Acromyrmex e...   118   3e-24
K2NID0_TRYCR (tr|K2NID0) Bifunctional dihydrofolate reductase-th...   118   3e-24
H9YW18_MACMU (tr|H9YW18) Dihydrofolate reductase OS=Macaca mulat...   118   3e-24
M9N265_ASHGS (tr|M9N265) FACR124Wp OS=Ashbya gossypii FDAG1 GN=F...   118   3e-24
E3LVK9_CAERE (tr|E3LVK9) CRE-DHFR-1 protein OS=Caenorhabditis re...   118   3e-24
Q95NY4_TRYCR (tr|Q95NY4) Bifunctional dihydrofolate reductase-th...   118   3e-24
D3JLA6_TRYCR (tr|D3JLA6) Bifunctional dihydrofolate reductase-th...   118   4e-24
I6LE99_TRYCR (tr|I6LE99) Bifunctional dihydrofolate reductase-th...   118   4e-24
A7TKP4_VANPO (tr|A7TKP4) Putative uncharacterized protein OS=Van...   117   4e-24
G1QES9_MYOLU (tr|G1QES9) Uncharacterized protein OS=Myotis lucif...   117   4e-24
E3TFQ6_ICTPU (tr|E3TFQ6) Dihydrofolate reductase OS=Ictalurus pu...   117   4e-24
H0Z9R7_TAEGU (tr|H0Z9R7) Uncharacterized protein OS=Taeniopygia ...   117   5e-24
Q544T5_MOUSE (tr|Q544T5) Dihydrofolate reductase OS=Mus musculus...   117   6e-24
G7MZ91_MACMU (tr|G7MZ91) Putative uncharacterized protein OS=Mac...   117   6e-24
H2QR61_PANTR (tr|H2QR61) Dihydrofolate reductase OS=Pan troglody...   117   6e-24
Q78EH1_9RODE (tr|Q78EH1) Dihydrofolate reductase OS=Cricetulus s...   117   6e-24
G7P7V4_MACFA (tr|G7P7V4) Putative uncharacterized protein (Fragm...   117   6e-24
I6LEA5_TRYCR (tr|I6LEA5) Bifunctional dihydrofolate reductase-th...   117   6e-24
Q963S8_TRYCR (tr|Q963S8) Bifunctional dihydrofolate reductase-th...   117   6e-24
Q78EE3_9RODE (tr|Q78EE3) Dihydrofolate reductase OS=Cricetulus s...   117   7e-24
C4WVU0_ACYPI (tr|C4WVU0) ACYPI002804 protein OS=Acyrthosiphon pi...   117   7e-24
B0YJ76_HUMAN (tr|B0YJ76) Dihydrofolate reductase OS=Homo sapiens...   117   7e-24
F6SNN4_MACMU (tr|F6SNN4) Uncharacterized protein OS=Macaca mulat...   117   8e-24
H9EWZ9_MACMU (tr|H9EWZ9) Dihydrofolate reductase OS=Macaca mulat...   116   9e-24
D8LBA4_ECTSI (tr|D8LBA4) Putative uncharacterized protein OS=Ect...   116   1e-23
M4A4Q9_XIPMA (tr|M4A4Q9) Uncharacterized protein OS=Xiphophorus ...   116   1e-23
H2W5E7_CAEJA (tr|H2W5E7) Uncharacterized protein OS=Caenorhabdit...   116   1e-23
E3QCI8_COLGM (tr|E3QCI8) Dihydrofolate reductase OS=Colletotrich...   116   1e-23
K7HWT8_CAEJA (tr|K7HWT8) Uncharacterized protein OS=Caenorhabdit...   116   1e-23
G3RQF8_GORGO (tr|G3RQF8) Uncharacterized protein OS=Gorilla gori...   116   1e-23
F7IFS4_CALJA (tr|F7IFS4) Uncharacterized protein OS=Callithrix j...   116   1e-23
B5U9U8_BABGI (tr|B5U9U8) Dihydrofolate reductase-thymidylate syn...   116   1e-23
I6LEA7_TRYCR (tr|I6LEA7) Bifunctional dihydrofolate reductase-th...   116   1e-23
B4PQL2_DROYA (tr|B4PQL2) GE24403 OS=Drosophila yakuba GN=Dyak\GE...   116   1e-23
E2BDW3_HARSA (tr|E2BDW3) Dihydrofolate reductase OS=Harpegnathos...   116   1e-23
F7IE26_CALJA (tr|F7IE26) Uncharacterized protein OS=Callithrix j...   116   1e-23
B4JFC4_DROGR (tr|B4JFC4) GH19291 OS=Drosophila grimshawi GN=Dgri...   115   2e-23
B3P134_DROER (tr|B3P134) GG17010 OS=Drosophila erecta GN=Dere\GG...   115   2e-23
B0X1Y0_CULQU (tr|B0X1Y0) Dihydrofolate reductase OS=Culex quinqu...   115   2e-23
F7HK25_MACMU (tr|F7HK25) Uncharacterized protein OS=Macaca mulat...   115   2e-23
F8UVS0_9BACT (tr|F8UVS0) Dihydrofolate reductase OS=uncultured b...   115   2e-23
M3YBC7_MUSPF (tr|M3YBC7) Uncharacterized protein OS=Mustela puto...   115   2e-23
K7HWT7_CAEJA (tr|K7HWT7) Uncharacterized protein OS=Caenorhabdit...   115   2e-23
Q548M5_PNECA (tr|Q548M5) Dihydrofolate reductase OS=Pneumocystis...   115   2e-23
R4XAK4_9ASCO (tr|R4XAK4) Dihydrofolate reductase OS=Taphrina def...   115   3e-23
L8I321_BOSMU (tr|L8I321) Dihydrofolate reductase OS=Bos grunnien...   114   3e-23
H2PG01_PONAB (tr|H2PG01) Uncharacterized protein OS=Pongo abelii...   114   4e-23
J8Q1T3_SACAR (tr|J8Q1T3) Dfr1p OS=Saccharomyces arboricola (stra...   114   4e-23
B6AE97_CRYMR (tr|B6AE97) Thymidylate synthase family protein OS=...   114   5e-23
G3BED0_CANTC (tr|G3BED0) Dihydrofolate reductase OS=Candida tenu...   114   5e-23
L5KJI5_PTEAL (tr|L5KJI5) Dihydrofolate reductase OS=Pteropus ale...   114   5e-23
I3JW88_ORENI (tr|I3JW88) Uncharacterized protein OS=Oreochromis ...   114   5e-23
M3XI69_LATCH (tr|M3XI69) Uncharacterized protein OS=Latimeria ch...   114   6e-23
I6LEA4_TRYCR (tr|I6LEA4) Bifunctional dihydrofolate reductase-th...   114   6e-23
B3RI81_TRIAD (tr|B3RI81) Putative uncharacterized protein OS=Tri...   114   7e-23
G4LU61_DROME (tr|G4LU61) FI15873p1 OS=Drosophila melanogaster GN...   114   7e-23
I3N257_SPETR (tr|I3N257) Uncharacterized protein OS=Spermophilus...   114   7e-23
D0LYN1_HALO1 (tr|D0LYN1) Dihydrofolate reductase OS=Haliangium o...   114   7e-23
B4IBU7_DROSE (tr|B4IBU7) GM15163 OS=Drosophila sechellia GN=Dsec...   113   8e-23
K6ZWI5_PANTR (tr|K6ZWI5) Dihydrofolate reductase OS=Pan troglody...   113   8e-23
B4QX21_DROSI (tr|B4QX21) GD19106 OS=Drosophila simulans GN=Dsim\...   113   9e-23
F7IE22_CALJA (tr|F7IE22) Uncharacterized protein OS=Callithrix j...   113   9e-23
B5XG28_SALSA (tr|B5XG28) Dihydrofolate reductase OS=Salmo salar ...   113   1e-22
D3JLA7_TRYCR (tr|D3JLA7) Bifunctional dihydrofolate reductase-th...   113   1e-22
Q86ZU9_COPCI (tr|Q86ZU9) Dihydrofolate reductase OS=Coprinopsis ...   113   1e-22
E7R791_PICAD (tr|E7R791) Dihydrofolate reductase OS=Pichia angus...   113   1e-22
M7SVA6_9PEZI (tr|M7SVA6) Uncharacterized protein OS=Eutypa lata ...   112   1e-22
G5BK75_HETGA (tr|G5BK75) Dihydrofolate reductase OS=Heterocephal...   112   1e-22
J9P092_CANFA (tr|J9P092) Uncharacterized protein (Fragment) OS=C...   112   2e-22
G2WNA5_YEASK (tr|G2WNA5) K7_Dfr1p OS=Saccharomyces cerevisiae (s...   112   2e-22
C7GWF0_YEAS2 (tr|C7GWF0) Dfr1p OS=Saccharomyces cerevisiae (stra...   112   2e-22
N1P3I2_YEASX (tr|N1P3I2) Dfr1p OS=Saccharomyces cerevisiae CEN.P...   112   2e-22
C8ZGZ0_YEAS8 (tr|C8ZGZ0) Dfr1p OS=Saccharomyces cerevisiae (stra...   112   2e-22
B3LJQ7_YEAS1 (tr|B3LJQ7) Dihydrofolate reductase OS=Saccharomyce...   112   2e-22
G1SN91_RABIT (tr|G1SN91) Uncharacterized protein (Fragment) OS=O...   112   2e-22
A6ZP76_YEAS7 (tr|A6ZP76) Dihydrofolate reductase OS=Saccharomyce...   112   2e-22
Q5CGA3_CRYHO (tr|Q5CGA3) Chain A, crystal structure of Dhfr OS=C...   112   2e-22
Q27552_CRYPV (tr|Q27552) Bifunctional dihydrofolate reductase-th...   112   2e-22
K1XL58_9BACT (tr|K1XL58) Dihydrofolate reductase OS=uncultured b...   112   2e-22
E1FRE1_LOALO (tr|E1FRE1) Dihydrofolate reductase OS=Loa loa GN=L...   112   2e-22
R7Z284_9EURO (tr|R7Z284) Dihydrofolate reductase OS=Coniosporium...   112   2e-22
K4FSM0_CALMI (tr|K4FSM0) Dihydrofolate reductase OS=Callorhynchu...   112   2e-22
G0VBB0_NAUCC (tr|G0VBB0) Uncharacterized protein OS=Naumovozyma ...   112   2e-22
L0P7T1_PNEJ8 (tr|L0P7T1) I WGS project CAKM00000000 data, strain...   112   2e-22
G3UJS8_LOXAF (tr|G3UJS8) Uncharacterized protein OS=Loxodonta af...   112   3e-22
G8ZMU1_TORDC (tr|G8ZMU1) Uncharacterized protein OS=Torulaspora ...   111   3e-22
L2G5J2_COLGN (tr|L2G5J2) Dihydrofolate reductase OS=Colletotrich...   111   3e-22
A5DKQ5_PICGU (tr|A5DKQ5) Putative uncharacterized protein OS=Mey...   111   3e-22
F1RF10_PIG (tr|F1RF10) Dihydrofolate reductase OS=Sus scrofa GN=...   111   3e-22
H0GNU8_9SACH (tr|H0GNU8) Dfr1p OS=Saccharomyces cerevisiae x Sac...   111   3e-22
Q27551_CRYPV (tr|Q27551) Bifunctional dihydrofolate reductase-th...   111   4e-22
E1ZW71_CAMFO (tr|E1ZW71) Dihydrofolate reductase OS=Camponotus f...   111   4e-22
Q5CPQ4_CRYPI (tr|Q5CPQ4) Bifunctional dihydrofolate reductase-th...   111   4e-22
H0VYF1_CAVPO (tr|H0VYF1) Uncharacterized protein OS=Cavia porcel...   111   4e-22
Q96V60_PNECA (tr|Q96V60) Dihydrofolate reductase (Fragment) OS=P...   111   4e-22
G3AV57_SPAPN (tr|G3AV57) Dihydrofolate reductase OS=Spathaspora ...   110   5e-22
Q6FPH0_CANGA (tr|Q6FPH0) Strain CBS138 chromosome J complete seq...   110   5e-22
A1UTA4_BARBK (tr|A1UTA4) Dihydrofolate reductase OS=Bartonella b...   110   6e-22
K8PLF8_BARBA (tr|K8PLF8) Dihydrofolate reductase OS=Bartonella b...   110   6e-22
G8BVS6_TETPH (tr|G8BVS6) Uncharacterized protein OS=Tetrapisispo...   110   8e-22
B5X910_SALSA (tr|B5X910) Dihydrofolate reductase OS=Salmo salar ...   110   9e-22
Q96V61_PNECA (tr|Q96V61) Dihydrofolate reductase (Fragment) OS=P...   110   9e-22
J9FQF0_9SPIT (tr|J9FQF0) Bifunctional dihydrofolate reductase-th...   110   9e-22
Q7VUE2_BORPE (tr|Q7VUE2) Dihydrofolate reductase OS=Bordetella p...   110   1e-21
J7RID2_BORP1 (tr|J7RID2) Dihydrofolate reductase OS=Bordetella p...   110   1e-21
F4LBK8_BORPC (tr|F4LBK8) Dihydrofolate reductase OS=Bordetella p...   110   1e-21
K1X891_MARBU (tr|K1X891) Dihydrofolate reductase OS=Marssonina b...   110   1e-21
M3KH97_9RHIZ (tr|M3KH97) Dihydrofolate reductase OS=Ochrobactrum...   109   1e-21
H3EN70_PRIPA (tr|H3EN70) Uncharacterized protein OS=Pristionchus...   109   1e-21
J0RGK6_9RHIZ (tr|J0RGK6) Dihydrofolate reductase OS=Bartonella t...   109   1e-21
J0QS16_9RHIZ (tr|J0QS16) Dihydrofolate reductase OS=Bartonella t...   109   1e-21
H3AFF7_LATCH (tr|H3AFF7) Uncharacterized protein OS=Latimeria ch...   109   1e-21
K0MMP7_BORBM (tr|K0MMP7) Dihydrofolate reductase OS=Bordetella b...   109   1e-21
K4TIS3_BORBO (tr|K4TIS3) Dihydrofolate reductase OS=Bordetella b...   109   1e-21
K4T4L7_BORBO (tr|K4T4L7) Dihydrofolate reductase OS=Bordetella b...   109   1e-21
Q4SM73_TETNG (tr|Q4SM73) Chromosome 13 SCAF14555, whole genome s...   109   1e-21
H3CSF7_TETNG (tr|H3CSF7) Uncharacterized protein OS=Tetraodon ni...   109   1e-21
H2P9Z5_PONAB (tr|H2P9Z5) Uncharacterized protein OS=Pongo abelii...   109   1e-21
C5DEY6_LACTC (tr|C5DEY6) KLTH0D10802p OS=Lachancea thermotoleran...   109   1e-21
I3XAS7_RHIFR (tr|I3XAS7) Dihydrofolate reductase OS=Sinorhizobiu...   109   1e-21
M7NWY1_9ASCO (tr|M7NWY1) Dihydrofolate reductase OS=Pneumocystis...   109   1e-21
F8QC10_SERL3 (tr|F8QC10) Putative uncharacterized protein OS=Ser...   109   2e-21
F8PBC3_SERL9 (tr|F8PBC3) Putative uncharacterized protein OS=Ser...   109   2e-21
H2MP65_ORYLA (tr|H2MP65) Uncharacterized protein OS=Oryzias lati...   109   2e-21
G3J7I8_CORMM (tr|G3J7I8) Dihydrofolate reductase OS=Cordyceps mi...   109   2e-21
G2R8V7_THITE (tr|G2R8V7) Putative uncharacterized protein OS=Thi...   108   2e-21
K7GA32_PELSI (tr|K7GA32) Uncharacterized protein OS=Pelodiscus s...   108   2e-21
K1VN14_TRIAC (tr|K1VN14) Dihydrofolate reductase OS=Trichosporon...   108   2e-21
C1JLF0_RABIT (tr|C1JLF0) Dihydrofolate reductase OS=Oryctolagus ...   108   2e-21
L9KL07_TUPCH (tr|L9KL07) Dihydrofolate reductase (Fragment) OS=T...   108   2e-21
A0EPW7_PNEJI (tr|A0EPW7) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   108   2e-21
G9A878_RHIFH (tr|G9A878) Dihydrofolate reductase OS=Rhizobium fr...   108   2e-21
I1RSS7_GIBZE (tr|I1RSS7) Uncharacterized protein OS=Gibberella z...   108   2e-21
H3ADL5_LATCH (tr|H3ADL5) Uncharacterized protein OS=Latimeria ch...   108   3e-21
N4X332_COCHE (tr|N4X332) Uncharacterized protein OS=Bipolaris ma...   108   3e-21
M2TVB6_COCHE (tr|M2TVB6) Uncharacterized protein OS=Bipolaris ma...   108   3e-21
C4XYS3_CLAL4 (tr|C4XYS3) Putative uncharacterized protein OS=Cla...   108   3e-21
C1BZA4_ESOLU (tr|C1BZA4) Dihydrofolate reductase OS=Esox lucius ...   108   3e-21
J5TAU2_TRIAS (tr|J5TAU2) Dihydrofolate reductase OS=Trichosporon...   108   3e-21
D3TQQ1_GLOMM (tr|D3TQQ1) Dihydrofolate reductase OS=Glossina mor...   108   3e-21
K4QLZ5_BORBO (tr|K4QLZ5) Dihydrofolate reductase OS=Bordetella b...   108   4e-21
F1LGH0_ASCSU (tr|F1LGH0) Dihydrofolate reductase (Fragment) OS=A...   108   4e-21
F4QJU5_9CAUL (tr|F4QJU5) Dihydrofolate reductase OS=Asticcacauli...   107   5e-21
Q6CRP4_KLULA (tr|Q6CRP4) KLLA0D07458p OS=Kluyveromyces lactis (s...   107   5e-21
A3RKL3_CHICK (tr|A3RKL3) Dihydrofolate reductase OS=Gallus gallu...   107   5e-21
H2AN61_KAZAF (tr|H2AN61) Uncharacterized protein OS=Kazachstania...   107   5e-21
G4VJD6_SCHMA (tr|G4VJD6) Dihydrofolate reductase OS=Schistosoma ...   107   6e-21
M7AXP5_CHEMY (tr|M7AXP5) Dihydrofolate reductase OS=Chelonia myd...   107   6e-21
R6F0T7_9FIRM (tr|R6F0T7) Dihydrofolate reductase OS=Firmicutes b...   107   8e-21
J1J9P7_BARDO (tr|J1J9P7) Dihydrofolate reductase OS=Bartonella d...   107   8e-21
F4QYC2_BREDI (tr|F4QYC2) Dihydrofolate reductase OS=Brevundimona...   107   8e-21
Q7WP14_BORBR (tr|Q7WP14) Dihydrofolate reductase OS=Bordetella b...   106   9e-21
K4KLF7_SIMAS (tr|K4KLF7) Dihydrofolate reductase OS=Simiduia aga...   106   1e-20
K4TYB3_BORBO (tr|K4TYB3) Dihydrofolate reductase OS=Bordetella b...   106   1e-20
C5DXQ4_ZYGRC (tr|C5DXQ4) ZYRO0F06930p OS=Zygosaccharomyces rouxi...   106   1e-20
Q7W1B0_BORPA (tr|Q7W1B0) Dihydrofolate reductase OS=Bordetella p...   106   1e-20
A3J0E0_9FLAO (tr|A3J0E0) Dihydrofolate reductase OS=Flavobacteri...   106   1e-20
C6XT74_PEDHD (tr|C6XT74) Dihydrofolate reductase OS=Pedobacter h...   106   1e-20
C3MEC3_RHISN (tr|C3MEC3) Dihydrofolate reductase OS=Rhizobium sp...   106   1e-20
Q05GI2_ECOLX (tr|Q05GI2) Dihydrofolate reductase OS=Escherichia ...   106   1e-20
B0CPS0_LACBS (tr|B0CPS0) Predicted protein OS=Laccaria bicolor (...   106   1e-20
Q28J42_XENTR (tr|Q28J42) Dihydrofolate reductase OS=Xenopus trop...   106   1e-20
B4W5U5_9CAUL (tr|B4W5U5) Dihydrofolate reductase OS=Brevundimona...   106   1e-20
A0SIB3_PNEJI (tr|A0SIB3) Dihydrofolate reductase OS=Pneumocystis...   106   1e-20
K0MBI9_BORPB (tr|K0MBI9) Dihydrofolate reductase OS=Bordetella p...   106   1e-20
D3NQH5_AZOS1 (tr|D3NQH5) Dihydrofolate reductase OS=Azospirillum...   105   2e-20
R0ABK3_CLOBU (tr|R0ABK3) Uncharacterized protein OS=Clostridium ...   105   2e-20
M8JYM0_CLOBU (tr|M8JYM0) Dihydrofolate reductase OS=Clostridium ...   105   2e-20
G3UMZ7_LOXAF (tr|G3UMZ7) Uncharacterized protein OS=Loxodonta af...   105   2e-20
A0EPX5_PNEJI (tr|A0EPX5) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   105   2e-20
C4IMY7_CLOBU (tr|C4IMY7) Dihydrofolate reductase OS=Clostridium ...   105   2e-20
B1QY68_CLOBU (tr|B1QY68) Dihydrofolate reductase OS=Clostridium ...   105   2e-20
H2S6U1_TAKRU (tr|H2S6U1) Uncharacterized protein OS=Takifugu rub...   105   2e-20
J7S268_KAZNA (tr|J7S268) Uncharacterized protein OS=Kazachstania...   105   2e-20
Q9DSS3_SHV2 (tr|Q9DSS3) Dihydrofolate reductase OS=Saimiriine he...   105   2e-20
A0EPW5_PNEJI (tr|A0EPW5) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   105   2e-20
I2GYN0_TETBL (tr|I2GYN0) Uncharacterized protein OS=Tetrapisispo...   105   2e-20
J1JNN6_9RHIZ (tr|J1JNN6) Dihydrofolate reductase OS=Bartonella w...   105   2e-20
B4NBB6_DROWI (tr|B4NBB6) GK11864 OS=Drosophila willistoni GN=Dwi...   105   2e-20
G1RR95_NOMLE (tr|G1RR95) Uncharacterized protein OS=Nomascus leu...   105   2e-20
A0EPY5_PNEJI (tr|A0EPY5) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   105   2e-20
A0EPY9_PNEJI (tr|A0EPY9) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   105   3e-20
L8FWM8_GEOD2 (tr|L8FWM8) Dihydrofolate reductase OS=Geomyces des...   105   3e-20
A0EPX1_PNEJI (tr|A0EPX1) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   105   3e-20
Q68KH6_PNEJI (tr|Q68KH6) Dihydrofolate reductase OS=Pneumocystis...   105   3e-20
C7SAR2_PNEJI (tr|C7SAR2) Dihydrofolate reductase OS=Pneumocystis...   105   3e-20
Q9UUP5_PNEJI (tr|Q9UUP5) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   105   3e-20
Q68KH4_PNEJI (tr|Q68KH4) Dihydrofolate reductase OS=Pneumocystis...   105   3e-20
I2FY93_USTH4 (tr|I2FY93) Related to Dihydrofolate reductase OS=U...   105   3e-20
G3PJP3_GASAC (tr|G3PJP3) Uncharacterized protein OS=Gasterosteus...   105   3e-20
A0SIB4_PNEJI (tr|A0SIB4) Dihydrofolate reductase OS=Pneumocystis...   105   3e-20
Q55L31_CRYNB (tr|Q55L31) Putative uncharacterized protein OS=Cry...   105   3e-20
A6WZV5_OCHA4 (tr|A6WZV5) Dihydrofolate reductase OS=Ochrobactrum...   105   3e-20
Q68KH7_PNEJI (tr|Q68KH7) Dihydrofolate reductase OS=Pneumocystis...   105   3e-20
A0EPY3_PNEJI (tr|A0EPY3) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   104   3e-20
A0EPY1_PNEJI (tr|A0EPY1) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   104   3e-20
D3TND9_GLOMM (tr|D3TND9) Dihydrofolate reductase OS=Glossina mor...   104   4e-20
C6AEH4_BARGA (tr|C6AEH4) Dihydrofolate reductase OS=Bartonella g...   104   4e-20
J9VT85_CRYNH (tr|J9VT85) Dihydrofolate reductase OS=Cryptococcus...   104   4e-20
A0SIB6_PNEJI (tr|A0SIB6) Dihydrofolate reductase OS=Pneumocystis...   104   4e-20
N7TM33_BRUAO (tr|N7TM33) Uncharacterized protein OS=Brucella abo...   104   4e-20
Q7Z0Z9_BABBO (tr|Q7Z0Z9) Dihydrofolate reductase/thymidilate syn...   104   4e-20
Q68KG9_PNEJI (tr|Q68KG9) Dihydrofolate reductase OS=Pneumocystis...   104   4e-20
A7T5F9_NEMVE (tr|A7T5F9) Predicted protein (Fragment) OS=Nematos...   104   4e-20
L1QL14_BREDI (tr|L1QL14) Dihydrofolate reductase OS=Brevundimona...   104   4e-20
K5XDG7_PHACS (tr|K5XDG7) Uncharacterized protein OS=Phanerochaet...   104   4e-20
J7LRG0_9MICC (tr|J7LRG0) Dihydrofolate reductase FolA OS=Arthrob...   104   5e-20
K4IGS1_PSYTT (tr|K4IGS1) Dihydrofolate reductase OS=Psychroflexu...   104   5e-20
A6EGV0_9SPHI (tr|A6EGV0) Dihydrofolate reductase OS=Pedobacter s...   104   5e-20
M4AXY9_XIPMA (tr|M4AXY9) Uncharacterized protein OS=Xiphophorus ...   104   5e-20
A0EQ07_PNEJI (tr|A0EQ07) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   104   5e-20
A7ASX7_BABBO (tr|A7ASX7) Dihydrofolate reductase/thymidylate syn...   104   6e-20
Q68KI2_PNEJI (tr|Q68KI2) Dihydrofolate reductase OS=Pneumocystis...   103   6e-20
D6LNG9_9RHIZ (tr|D6LNG9) Dihydrofolate reductase OS=Brucella sp....   103   6e-20
K7GA37_PELSI (tr|K7GA37) Uncharacterized protein OS=Pelodiscus s...   103   6e-20
Q7RGH7_PLAYO (tr|Q7RGH7) Thymidylate synthase, putative OS=Plasm...   103   6e-20
R6A6D6_9PROT (tr|R6A6D6) Dihydrofolate reductase OS=Proteobacter...   103   7e-20
A1R8Y8_ARTAT (tr|A1R8Y8) Dihydrofolate reductase OS=Arthrobacter...   103   7e-20
J1JJZ4_BAREL (tr|J1JJZ4) Dihydrofolate reductase OS=Bartonella e...   103   7e-20
J0R955_BAREL (tr|J0R955) Dihydrofolate reductase OS=Bartonella e...   103   7e-20
N8LL73_BRUML (tr|N8LL73) Uncharacterized protein OS=Brucella mel...   103   7e-20
N8EKE0_BRUML (tr|N8EKE0) Uncharacterized protein OS=Brucella mel...   103   7e-20
N7NG59_BRUML (tr|N7NG59) Uncharacterized protein OS=Brucella mel...   103   7e-20
N7MRG1_BRUML (tr|N7MRG1) Uncharacterized protein OS=Brucella mel...   103   7e-20
D1F9R4_BRUML (tr|D1F9R4) Dihydrofolate reductase OS=Brucella mel...   103   7e-20
E0DY33_9RHIZ (tr|E0DY33) Dihydrofolate reductase OS=Brucella sp....   103   7e-20
D1CYY5_9RHIZ (tr|D1CYY5) Dihydrofolate reductase OS=Brucella sp....   103   7e-20
A0SIB5_PNEJI (tr|A0SIB5) Dihydrofolate reductase (Fragment) OS=P...   103   8e-20
N8FZC5_9RHIZ (tr|N8FZC5) Uncharacterized protein OS=Brucella sp....   103   8e-20
M2SM79_COCSA (tr|M2SM79) Uncharacterized protein OS=Bipolaris so...   103   8e-20
A0EPX9_PNEJI (tr|A0EPX9) DHFR OS=Pneumocystis jiroveci GN=DHFR P...   103   8e-20
Q68KH1_PNEJI (tr|Q68KH1) Dihydrofolate reductase OS=Pneumocystis...   103   9e-20
C7YNN0_NECH7 (tr|C7YNN0) Predicted protein OS=Nectria haematococ...   103   9e-20
G9N9M2_HYPVG (tr|G9N9M2) Uncharacterized protein OS=Hypocrea vir...   103   1e-19
Q8YI36_BRUME (tr|Q8YI36) Dihydrofolate reductase OS=Brucella mel...   103   1e-19
Q8FZS4_BRUSU (tr|Q8FZS4) Dihydrofolate reductase OS=Brucella sui...   103   1e-19
Q57CB0_BRUAB (tr|Q57CB0) Dihydrofolate reductase OS=Brucella abo...   103   1e-19
Q2YS23_BRUA2 (tr|Q2YS23) Dihydrofolate reductase OS=Brucella abo...   103   1e-19
F2HV16_BRUMM (tr|F2HV16) Dihydrofolate reductase OS=Brucella mel...   103   1e-19
F2GQ95_BRUM5 (tr|F2GQ95) Dihydrofolate reductase OS=Brucella mel...   103   1e-19
C9TX34_BRUPB (tr|C9TX34) Dihydrofolate reductase OS=Brucella pin...   103   1e-19
C7LCZ1_BRUMC (tr|C7LCZ1) Dihydrofolate reductase OS=Brucella mic...   103   1e-19
C0RE37_BRUMB (tr|C0RE37) Dihydrofolate reductase OS=Brucella mel...   103   1e-19
B2S6M2_BRUA1 (tr|B2S6M2) Dihydrofolate reductase OS=Brucella abo...   103   1e-19
B0CHI6_BRUSI (tr|B0CHI6) Dihydrofolate reductase OS=Brucella sui...   103   1e-19
R8WDB6_BRUAO (tr|R8WDB6) Uncharacterized protein OS=Brucella abo...   103   1e-19
R8W7R1_BRUAO (tr|R8W7R1) Uncharacterized protein OS=Brucella abo...   103   1e-19
N8LGQ9_BRUAO (tr|N8LGQ9) Uncharacterized protein OS=Brucella abo...   103   1e-19
N8KW63_BRUSS (tr|N8KW63) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8KNS6_BRUSS (tr|N8KNS6) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8K5N2_BRUSS (tr|N8K5N2) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8JTQ7_BRUML (tr|N8JTQ7) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8JQK5_BRUSS (tr|N8JQK5) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8JND6_BRUSS (tr|N8JND6) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8JE14_BRUSS (tr|N8JE14) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8JA02_BRUSS (tr|N8JA02) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8IYQ7_BRUSS (tr|N8IYQ7) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8IL41_BRUSS (tr|N8IL41) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8HUS1_BRUSS (tr|N8HUS1) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8HGL2_9RHIZ (tr|N8HGL2) Uncharacterized protein OS=Brucella sp....   103   1e-19
N8HFV4_BRUSS (tr|N8HFV4) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8H5S0_BRUSS (tr|N8H5S0) Uncharacterized protein OS=Brucella sui...   103   1e-19
N8GVB5_9RHIZ (tr|N8GVB5) Uncharacterized protein OS=Brucella sp....   103   1e-19
N8GCM9_9RHIZ (tr|N8GCM9) Uncharacterized protein OS=Brucella sp....   103   1e-19
N8G3U5_9RHIZ (tr|N8G3U5) Uncharacterized protein OS=Brucella sp....   103   1e-19
N8FLW7_9RHIZ (tr|N8FLW7) Uncharacterized protein OS=Brucella sp....   103   1e-19
N8EXY6_BRUML (tr|N8EXY6) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8EG34_BRUML (tr|N8EG34) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8ECH6_9RHIZ (tr|N8ECH6) Uncharacterized protein OS=Brucella sp....   103   1e-19
N8E3J2_BRUML (tr|N8E3J2) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8CGT6_BRUML (tr|N8CGT6) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8BMU3_BRUML (tr|N8BMU3) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8BHP3_BRUML (tr|N8BHP3) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8ATT4_BRUML (tr|N8ATT4) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8AT99_BRUAO (tr|N8AT99) Uncharacterized protein OS=Brucella abo...   103   1e-19
N8AQZ5_BRUAO (tr|N8AQZ5) Uncharacterized protein OS=Brucella abo...   103   1e-19
N8AK89_BRUML (tr|N8AK89) Uncharacterized protein OS=Brucella mel...   103   1e-19
N8AAS5_BRUAO (tr|N8AAS5) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7ZWX2_BRUAO (tr|N7ZWX2) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7ZU49_BRUAO (tr|N7ZU49) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7ZMU6_BRUAO (tr|N7ZMU6) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7ZD67_BRUAO (tr|N7ZD67) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7Z3P2_BRUAO (tr|N7Z3P2) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7YNY1_BRUAO (tr|N7YNY1) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7Y1W8_BRUAO (tr|N7Y1W8) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7XUX3_BRUAO (tr|N7XUX3) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7X8X2_BRUAO (tr|N7X8X2) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7X8F5_BRUAO (tr|N7X8F5) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7X786_BRUAO (tr|N7X786) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7X1N2_BRUAO (tr|N7X1N2) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7WP94_BRUAO (tr|N7WP94) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7WC96_BRUAO (tr|N7WC96) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7W8A0_BRUAO (tr|N7W8A0) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7VK42_BRUAO (tr|N7VK42) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7V0R8_BRUAO (tr|N7V0R8) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7UQZ9_BRUAO (tr|N7UQZ9) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7U9I3_BRUAO (tr|N7U9I3) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7TSZ6_BRUAO (tr|N7TSZ6) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7TSF5_BRUAO (tr|N7TSF5) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7TQW3_BRUAO (tr|N7TQW3) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7T9Y3_BRUAO (tr|N7T9Y3) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7T569_BRUAO (tr|N7T569) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7T249_BRUAO (tr|N7T249) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7SY59_BRUAO (tr|N7SY59) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7SXC1_BRUAO (tr|N7SXC1) Uncharacterized protein OS=Brucella abo...   103   1e-19
N7SKZ2_BRUSS (tr|N7SKZ2) Uncharacterized protein OS=Brucella sui...   103   1e-19

>I1K754_SOYBN (tr|I1K754) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 568

 Score =  473 bits (1217), Expect = e-131,   Method: Compositional matrix adjust.
 Identities = 232/325 (71%), Positives = 256/325 (78%)

Query: 4   SYSRLWKIPLQFPKNRPCSPCFQTVSSSFCRFLSSMMTGDSFVVXXXXXXXXXXPLPNLQ 63
           S+     I L FPKN  CSPCFQT S S+CR LSS+M  DS V+          PLPNLQ
Sbjct: 3   SFCSFLTISLHFPKNWLCSPCFQTPSLSYCRRLSSIMPSDSSVISNGHSNGSVNPLPNLQ 62

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           RTYQVVVAAT+D GIGKDGKLPWRL TDLKFFKEIT  TSDPGKKNAIVMGRKTWESIPL
Sbjct: 63  RTYQVVVAATQDWGIGKDGKLPWRLPTDLKFFKEITMKTSDPGKKNAIVMGRKTWESIPL 122

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           +YRPL GRLNVVLTRSGSFDI TAENVVICGS+          PY LSIEKVFVIGGGQI
Sbjct: 123 EYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSSALELLAASPYSLSIEKVFVIGGGQI 182

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
           FRE LN PGCEAIH TEI +SIECDTFMPPVD T ++ WYSSFPKVEN+IRYSF TYVRV
Sbjct: 183 FREALNVPGCEAIHLTEIQSSIECDTFMPPVDFTIFRPWYSSFPKVENNIRYSFTTYVRV 242

Query: 244 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 303
           +SSAAES  QN DPL DNNS+S+KFEV++F FLP+MI +RHEEY+YL+L+Q+II+E    
Sbjct: 243 RSSAAESAGQNIDPLLDNNSESMKFEVKDFSFLPKMISERHEEYLYLKLVQDIIAEGTTK 302

Query: 304 XXXXXXXXLSKFGCQMRFNLRRSFP 328
                   LSKFGCQMRFNLR +FP
Sbjct: 303 GDRTGTGTLSKFGCQMRFNLRGNFP 327


>I1K753_SOYBN (tr|I1K753) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 530

 Score =  435 bits (1118), Expect = e-119,   Method: Compositional matrix adjust.
 Identities = 211/289 (73%), Positives = 232/289 (80%)

Query: 40  MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 99
           M  DS V+          PLPNLQRTYQVVVAAT+D GIGKDGKLPWRL TDLKFFKEIT
Sbjct: 1   MPSDSSVISNGHSNGSVNPLPNLQRTYQVVVAATQDWGIGKDGKLPWRLPTDLKFFKEIT 60

Query: 100 TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 159
             TSDPGKKNAIVMGRKTWESIPL+YRPL GRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 61  MKTSDPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSSA 120

Query: 160 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 219
                  PY LSIEKVFVIGGGQIFRE LN PGCEAIH TEI +SIECDTFMPPVD T +
Sbjct: 121 LELLAASPYSLSIEKVFVIGGGQIFREALNVPGCEAIHLTEIQSSIECDTFMPPVDFTIF 180

Query: 220 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           + WYSSFPKVEN+IRYSF TYVRV+SSAAES  QN DPL DNNS+S+KFEV++F FLP+M
Sbjct: 181 RPWYSSFPKVENNIRYSFTTYVRVRSSAAESAGQNIDPLLDNNSESMKFEVKDFSFLPKM 240

Query: 280 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           I +RHEEY+YL+L+Q+II+E            LSKFGCQMRFNLR +FP
Sbjct: 241 ISERHEEYLYLKLVQDIIAEGTTKGDRTGTGTLSKFGCQMRFNLRGNFP 289


>G7J766_MEDTR (tr|G7J766) Dihydrofolate reductase-thymidylate synthase
           OS=Medicago truncatula GN=MTR_3g117080 PE=3 SV=1
          Length = 558

 Score =  423 bits (1088), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 217/321 (67%), Positives = 240/321 (74%), Gaps = 7/321 (2%)

Query: 10  KIPLQFPKNRPCSPCFQ-TVSSSFCR-FLSSMMTGDSFVVXXXXXXXXXXPLPNLQRTYQ 67
           +I L F KN  CSP F    S S CR FLSS M GDS  +             NLQRTYQ
Sbjct: 2   EIALHFQKNWLCSPYFHPNQSLSLCRRFLSSTMAGDSSAIFNGNGNGSI----NLQRTYQ 57

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           VVVAATK+MGIGKDGKLPWRL TDLKFFKEITT TS+PGKKNAIVMGRKTWESIPL++RP
Sbjct: 58  VVVAATKEMGIGKDGKLPWRLPTDLKFFKEITTTTSEPGKKNAIVMGRKTWESIPLQFRP 117

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GRLNVVLTRSG+FDI  AENVVIC S+          PY  SIEK+FVIGGG+IFRE 
Sbjct: 118 LLGRLNVVLTRSGTFDIAAAENVVICRSMSSALELLAASPYHTSIEKIFVIGGGEIFREA 177

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSA 247
           LNAP CEAIH TEI ++IECDTFMPP+D+T +Q WYSSF KVEN+IRYSF TYVRV+SSA
Sbjct: 178 LNAPECEAIHLTEIQSNIECDTFMPPIDTTIFQPWYSSFTKVENNIRYSFTTYVRVRSSA 237

Query: 248 AESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXX 307
           AE   +NTD  FD+NS S KFEVQNF FLP+MI +RH EYMYL L+QEIIS+        
Sbjct: 238 AE-YPKNTDSFFDSNSASKKFEVQNFSFLPKMIFERHAEYMYLNLVQEIISQGTTKGDRT 296

Query: 308 XXXXLSKFGCQMRFNLRRSFP 328
               LS FGCQMRFNLRR FP
Sbjct: 297 GTGTLSAFGCQMRFNLRRGFP 317


>G7J765_MEDTR (tr|G7J765) Dihydrofolate reductase-thymidylate synthase
           OS=Medicago truncatula GN=MTR_3g117080 PE=3 SV=1
          Length = 569

 Score =  423 bits (1087), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 217/320 (67%), Positives = 239/320 (74%), Gaps = 7/320 (2%)

Query: 11  IPLQFPKNRPCSPCFQ-TVSSSFCR-FLSSMMTGDSFVVXXXXXXXXXXPLPNLQRTYQV 68
           I L F KN  CSP F    S S CR FLSS M GDS  +             NLQRTYQV
Sbjct: 14  IALHFQKNWLCSPYFHPNQSLSLCRRFLSSTMAGDSSAIFNGNGNGSI----NLQRTYQV 69

Query: 69  VVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPL 128
           VVAATK+MGIGKDGKLPWRL TDLKFFKEITT TS+PGKKNAIVMGRKTWESIPL++RPL
Sbjct: 70  VVAATKEMGIGKDGKLPWRLPTDLKFFKEITTTTSEPGKKNAIVMGRKTWESIPLQFRPL 129

Query: 129 PGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVL 188
            GRLNVVLTRSG+FDI  AENVVIC S+          PY  SIEK+FVIGGG+IFRE L
Sbjct: 130 LGRLNVVLTRSGTFDIAAAENVVICRSMSSALELLAASPYHTSIEKIFVIGGGEIFREAL 189

Query: 189 NAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAA 248
           NAP CEAIH TEI ++IECDTFMPP+D+T +Q WYSSF KVEN+IRYSF TYVRV+SSAA
Sbjct: 190 NAPECEAIHLTEIQSNIECDTFMPPIDTTIFQPWYSSFTKVENNIRYSFTTYVRVRSSAA 249

Query: 249 ESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXX 308
           E   +NTD  FD+NS S KFEVQNF FLP+MI +RH EYMYL L+QEIIS+         
Sbjct: 250 E-YPKNTDSFFDSNSASKKFEVQNFSFLPKMIFERHAEYMYLNLVQEIISQGTTKGDRTG 308

Query: 309 XXXLSKFGCQMRFNLRRSFP 328
              LS FGCQMRFNLRR FP
Sbjct: 309 TGTLSAFGCQMRFNLRRGFP 328


>G7J767_MEDTR (tr|G7J767) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Medicago truncatula GN=MTR_3g117080 PE=3
           SV=1
          Length = 504

 Score =  423 bits (1087), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 217/321 (67%), Positives = 239/321 (74%), Gaps = 7/321 (2%)

Query: 10  KIPLQFPKNRPCSPCFQ-TVSSSFCR-FLSSMMTGDSFVVXXXXXXXXXXPLPNLQRTYQ 67
            I L F KN  CSP F    S S CR FLSS M GDS  +             NLQRTYQ
Sbjct: 13  NIALHFQKNWLCSPYFHPNQSLSLCRRFLSSTMAGDSSAIFNGNGNGSI----NLQRTYQ 68

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           VVVAATK+MGIGKDGKLPWRL TDLKFFKEITT TS+PGKKNAIVMGRKTWESIPL++RP
Sbjct: 69  VVVAATKEMGIGKDGKLPWRLPTDLKFFKEITTTTSEPGKKNAIVMGRKTWESIPLQFRP 128

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GRLNVVLTRSG+FDI  AENVVIC S+          PY  SIEK+FVIGGG+IFRE 
Sbjct: 129 LLGRLNVVLTRSGTFDIAAAENVVICRSMSSALELLAASPYHTSIEKIFVIGGGEIFREA 188

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSA 247
           LNAP CEAIH TEI ++IECDTFMPP+D+T +Q WYSSF KVEN+IRYSF TYVRV+SSA
Sbjct: 189 LNAPECEAIHLTEIQSNIECDTFMPPIDTTIFQPWYSSFTKVENNIRYSFTTYVRVRSSA 248

Query: 248 AESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXX 307
           AE   +NTD  FD+NS S KFEVQNF FLP+MI +RH EYMYL L+QEIIS+        
Sbjct: 249 AE-YPKNTDSFFDSNSASKKFEVQNFSFLPKMIFERHAEYMYLNLVQEIISQGTTKGDRT 307

Query: 308 XXXXLSKFGCQMRFNLRRSFP 328
               LS FGCQMRFNLRR FP
Sbjct: 308 GTGTLSAFGCQMRFNLRRGFP 328


>K7KHI6_SOYBN (tr|K7KHI6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 530

 Score =  422 bits (1085), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 206/289 (71%), Positives = 228/289 (78%)

Query: 40  MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 99
           M GDS V+          PL NL+RTYQV+VAAT+D GIGKDGKLPWRL TDLKFFK+IT
Sbjct: 1   MAGDSSVMSNGYSKGSVNPLTNLRRTYQVLVAATQDWGIGKDGKLPWRLPTDLKFFKDIT 60

Query: 100 TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 159
             TSDPGKKNAIVMGRKTWESIPL+YRPL GRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 61  VKTSDPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSSA 120

Query: 160 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 219
                  PY LSIEKVFVIGGGQIFRE LNAPGCEAIH TEI +SIECDTFMPPVD T +
Sbjct: 121 LELLAASPYSLSIEKVFVIGGGQIFREALNAPGCEAIHLTEIQSSIECDTFMPPVDFTMF 180

Query: 220 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           + WYSSFPKVEN+IRY F TYVRV+SSA ES  QN D L DNNS+S+KFEV+ F FLP+M
Sbjct: 181 RPWYSSFPKVENNIRYCFTTYVRVRSSAPESPGQNIDQLLDNNSESMKFEVKEFSFLPKM 240

Query: 280 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           I +RHEEY+YL+L+Q+II+E            LSKFGCQMRFNL  SFP
Sbjct: 241 ISERHEEYLYLKLVQDIIAEGTTKDDRTGTGTLSKFGCQMRFNLHGSFP 289


>Q8L6F0_PEA (tr|Q8L6F0) Dihydrofolate reductase-thymidylate synthase OS=Pisum
           sativum GN=dhfrts1 PE=2 SV=1
          Length = 530

 Score =  417 bits (1072), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 202/289 (69%), Positives = 223/289 (77%)

Query: 40  MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 99
           M  DS V+          P+PNLQRTYQVVVAATKDMGIGKDGKLPWRL TDLKFFKE+T
Sbjct: 1   MAADSSVMFNGNGNGSINPMPNLQRTYQVVVAATKDMGIGKDGKLPWRLPTDLKFFKELT 60

Query: 100 TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 159
           T T + GKKNAIVMGRKTWESIPL++RPLPGRLNVVLTRSGSFD   AENVVICGS+   
Sbjct: 61  TTTFETGKKNAIVMGRKTWESIPLQFRPLPGRLNVVLTRSGSFDAKAAENVVICGSMSSA 120

Query: 160 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 219
                  PYC SIEK+FVIGGG+IFR+ LN P CEAIH TEIH S ECDTFMPP+D T +
Sbjct: 121 LELLAASPYCTSIEKIFVIGGGEIFRDALNVPECEAIHITEIHTSFECDTFMPPIDFTTF 180

Query: 220 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           + WYSSFPKVEN+IRYSF TYVRV+SS AESL+Q+T    DN   S KFEVQNF FLP+M
Sbjct: 181 RPWYSSFPKVENNIRYSFTTYVRVRSSVAESLNQSTVSPLDNKPASKKFEVQNFSFLPKM 240

Query: 280 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           I +RHEEYMYL L+QEIIS+            LSKFGCQMRFNLRR FP
Sbjct: 241 IFERHEEYMYLNLVQEIISQGTSKGDRTGTGTLSKFGCQMRFNLRRGFP 289


>K7LP84_SOYBN (tr|K7LP84) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Glycine max PE=3 SV=1
          Length = 618

 Score =  407 bits (1047), Expect = e-111,   Method: Compositional matrix adjust.
 Identities = 198/303 (65%), Positives = 225/303 (74%), Gaps = 2/303 (0%)

Query: 26  QTVSSSFCRFLSSMMTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLP 85
           +  S    R LS +M  DS V+          P P  QRTYQ VV AT+DMGI KD KLP
Sbjct: 77  ENSSRKIFRLLSPIMASDSLVISNGNGNSKSEPHP--QRTYQAVVVATRDMGISKDEKLP 134

Query: 86  WRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIG 145
           W L TDL FF+EITT TSDPGKKNA+VMGRKTWESIP + RPLPGRLNVVLTRSGSFDI 
Sbjct: 135 WTLPTDLNFFEEITTTTSDPGKKNAVVMGRKTWESIPPENRPLPGRLNVVLTRSGSFDIA 194

Query: 146 TAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASI 205
           TAENV+ICGS+          PYCLSIEKVF+ GGG+IFRE LNAPGCEA H TEI ASI
Sbjct: 195 TAENVLICGSVSSAMELLASSPYCLSIEKVFLTGGGEIFREALNAPGCEAAHITEIEASI 254

Query: 206 ECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDS 265
           ECDTFMP V+++ +Q WYSSFP VE+++RYSF TYVRV+S   ES  QN DP FDNNSD+
Sbjct: 255 ECDTFMPRVNTSVFQTWYSSFPLVEDNLRYSFTTYVRVRSFPPESPDQNADPFFDNNSDA 314

Query: 266 LKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR 325
           LKFEV+ F FLP+M+ +RHEE+ YLRL+QEIISE            LSKFGCQMRFNLRR
Sbjct: 315 LKFEVKKFSFLPKMVYERHEEFKYLRLVQEIISEGTTKDDRTGTGTLSKFGCQMRFNLRR 374

Query: 326 SFP 328
           +FP
Sbjct: 375 NFP 377


>K7LSY4_SOYBN (tr|K7LSY4) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=1
          Length = 580

 Score =  402 bits (1034), Expect = e-110,   Method: Compositional matrix adjust.
 Identities = 196/303 (64%), Positives = 223/303 (73%)

Query: 26  QTVSSSFCRFLSSMMTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLP 85
           +  S    R LS +M  D+ V+             + QRTYQVVV AT+DMGI KD KLP
Sbjct: 41  ENSSRKIFRLLSPIMATDALVISNGNGNGNAKSELHPQRTYQVVVVATRDMGISKDAKLP 100

Query: 86  WRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIG 145
           W L T+LKFF+EITT TSDPGKKNA+VMGRKTWESIP + RPLPGRLNVVLTRSGSFDI 
Sbjct: 101 WTLPTELKFFEEITTTTSDPGKKNAVVMGRKTWESIPPENRPLPGRLNVVLTRSGSFDIA 160

Query: 146 TAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASI 205
           TAENV+ICGS+          PYCLSIEKVF+ GGG+IFRE LNAPGCEA H TEI ASI
Sbjct: 161 TAENVLICGSMASAMELLASSPYCLSIEKVFLTGGGEIFREALNAPGCEAAHITEIEASI 220

Query: 206 ECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDS 265
           ECDTFMP VD+  +Q WYSSFP VE+++RYSF TY RV+SS  E L QN DP F NNSDS
Sbjct: 221 ECDTFMPRVDTNVFQTWYSSFPLVEDNLRYSFTTYARVRSSPPEFLDQNADPFFYNNSDS 280

Query: 266 LKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRR 325
            KFEV+ F FLP+M+ +RHEE+ YLRL+QEIISE            LSKFGCQMRFNLRR
Sbjct: 281 FKFEVKKFSFLPKMVYERHEEFKYLRLVQEIISEGTTKDDRTGTGTLSKFGCQMRFNLRR 340

Query: 326 SFP 328
           +FP
Sbjct: 341 NFP 343


>M5VK78_PRUPE (tr|M5VK78) Uncharacterized protein OS=Prunus persica
           GN=PRUPE_ppa004093mg PE=4 SV=1
          Length = 530

 Score =  398 bits (1022), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 187/269 (69%), Positives = 217/269 (80%)

Query: 60  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 119
           PN QRTYQVVVAAT++MGIGKDGKLPWRL +DLKFFKE+T  TSDPGKKNA+VMGRKTWE
Sbjct: 21  PNPQRTYQVVVAATREMGIGKDGKLPWRLPSDLKFFKEVTVTTSDPGKKNAVVMGRKTWE 80

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           SI  ++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSI+KVF+IG
Sbjct: 81  SIAPEHRPLPGRLNVVLTRSGSFDIATAENVVICGSMASALELLAASPYCLSIDKVFIIG 140

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
           GGQI RE LNAPGC+AIH TEI   IECDTF+P +DS+ +Q WYSSFPKVEN IR+SF T
Sbjct: 141 GGQILREALNAPGCDAIHITEIETDIECDTFIPAIDSSVFQPWYSSFPKVENSIRHSFTT 200

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           YVRV SSA ESL QN D +  + SDS+K EV+NF FLP+MI ++HEE++YL L++EI+S+
Sbjct: 201 YVRVSSSAVESLCQNNDLISSSKSDSVKCEVKNFSFLPKMIFEKHEEHIYLSLVREILSD 260

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       LSKFGCQMRFNLRR+FP
Sbjct: 261 GTSKDDRTGTGTLSKFGCQMRFNLRRTFP 289


>I1LQ11_SOYBN (tr|I1LQ11) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Glycine max PE=3 SV=2
          Length = 530

 Score =  397 bits (1020), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 192/289 (66%), Positives = 217/289 (75%)

Query: 40  MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 99
           M  D+ V+             + QRTYQVVV AT+DMGI KD KLPW L T+LKFF+EIT
Sbjct: 1   MATDALVISNGNGNGNAKSELHPQRTYQVVVVATRDMGISKDAKLPWTLPTELKFFEEIT 60

Query: 100 TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 159
           T TSDPGKKNA+VMGRKTWESIP + RPLPGRLNVVLTRSGSFDI TAENV+ICGS+   
Sbjct: 61  TTTSDPGKKNAVVMGRKTWESIPPENRPLPGRLNVVLTRSGSFDIATAENVLICGSMASA 120

Query: 160 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 219
                  PYCLSIEKVF+ GGG+IFRE LNAPGCEA H TEI ASIECDTFMP VD+  +
Sbjct: 121 MELLASSPYCLSIEKVFLTGGGEIFREALNAPGCEAAHITEIEASIECDTFMPRVDTNVF 180

Query: 220 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           Q WYSSFP VE+++RYSF TY RV+SS  E L QN DP F NNSDS KFEV+ F FLP+M
Sbjct: 181 QTWYSSFPLVEDNLRYSFTTYARVRSSPPEFLDQNADPFFYNNSDSFKFEVKKFSFLPKM 240

Query: 280 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           + +RHEE+ YLRL+QEIISE            LSKFGCQMRFNLRR+FP
Sbjct: 241 VYERHEEFKYLRLVQEIISEGTTKDDRTGTGTLSKFGCQMRFNLRRNFP 289


>F6I0M2_VITVI (tr|F6I0M2) Putative uncharacterized protein OS=Vitis vinifera
           GN=VIT_03s0038g04500 PE=3 SV=1
          Length = 630

 Score =  392 bits (1008), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 198/318 (62%), Positives = 231/318 (72%), Gaps = 6/318 (1%)

Query: 11  IPLQFPKNRPCSPCFQTVSSSFCRFLSSMMTGDSFVVXXXXXXXXXXPLPNLQRTYQVVV 70
           + L F K+  CS  FQ+ S S      S+M  D+ VV          P P  QRTYQVVV
Sbjct: 78  VLLHFCKSWLCSLSFQSTSLSLHWVQDSIMASDT-VVSLPNGNANIQPDP--QRTYQVVV 134

Query: 71  AATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPG 130
           AAT+DMGIGKDGKLPWRL +D+K FK+IT   +D  KKNA++MGRKTWESIPL++RPLPG
Sbjct: 135 AATRDMGIGKDGKLPWRLPSDMKIFKDITMTVADTVKKNAVIMGRKTWESIPLEHRPLPG 194

Query: 131 RLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNA 190
           RLNVVLTRSGSFDI TAENVVICGS+          PYCLSIEKVFVIGGGQI RE LNA
Sbjct: 195 RLNVVLTRSGSFDIATAENVVICGSMASALELLAASPYCLSIEKVFVIGGGQILREALNA 254

Query: 191 PGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAES 250
           PGC+AIH TEI  S ECDTF+P +DS  +Q WYSSFP VEN+IRYSF TYVRV+SSA ES
Sbjct: 255 PGCDAIHITEIETSFECDTFIPAIDSLVFQPWYSSFPLVENNIRYSFMTYVRVRSSADES 314

Query: 251 LSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXX 310
             QN     D+  +S+KFEV+ F FLP+MI +RHEEY+YLRL+++IIS            
Sbjct: 315 QIQNNG---DSGLESIKFEVKKFSFLPKMIFERHEEYIYLRLVEDIISNGVQRDDRTGTG 371

Query: 311 XLSKFGCQMRFNLRRSFP 328
            LSKFGCQMRFNLR++FP
Sbjct: 372 TLSKFGCQMRFNLRKTFP 389


>B9H0T4_POPTR (tr|B9H0T4) Dihydrofolate reductase-thymidylate synthase OS=Populus
           trichocarpa GN=DHFR-TS-1 PE=2 SV=1
          Length = 528

 Score =  388 bits (996), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 185/289 (64%), Positives = 219/289 (75%), Gaps = 2/289 (0%)

Query: 40  MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 99
           M+GDS               P  ++TYQVVVAATKDMGIGKDGKLPW+L +DLKFFK++T
Sbjct: 1   MSGDSVANLSNGNANTQQSDP--RKTYQVVVAATKDMGIGKDGKLPWKLPSDLKFFKDLT 58

Query: 100 TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 159
             T D GKKNA++MGRKTWESIPL++RPLPGRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 59  LTTMDSGKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGSMGSA 118

Query: 160 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 219
                  PYCLSIEKVFVIGGGQI RE LNAPGC+AIH TEI    +CDTF+P +D++ +
Sbjct: 119 LELLAASPYCLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVF 178

Query: 220 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           Q WYSSFPKVENDIR+ F TYVRV+SS  ES SQN     D NS++ KFEV+ F FLP+M
Sbjct: 179 QPWYSSFPKVENDIRHCFTTYVRVRSSTIESHSQNNGENSDGNSENSKFEVKKFSFLPKM 238

Query: 280 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           + +RHEEY+YLR++Q+IIS+            LSKFGCQMRFNLR++FP
Sbjct: 239 VFERHEEYLYLRMVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRKNFP 287


>B0BLI5_LOTJA (tr|B0BLI5) CM0216.390.nc protein OS=Lotus japonicus
           GN=CM0216.390.nc PE=3 SV=1
          Length = 528

 Score =  377 bits (967), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 197/289 (68%), Positives = 218/289 (75%), Gaps = 2/289 (0%)

Query: 40  MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEIT 99
           M  DS V+            P  QRTYQ VV AT DMGI KDGKLPW L TD KFF+EIT
Sbjct: 1   MASDSLVISNGHDNGNLELSP--QRTYQAVVIATPDMGISKDGKLPWALPTDQKFFEEIT 58

Query: 100 TATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXX 159
           T TSDPGKKNA+VMGRK+WE+IP + RPL GRLNVVLTRSGSFDI TAENVVICGS+   
Sbjct: 59  TKTSDPGKKNAVVMGRKSWEAIPPEKRPLCGRLNVVLTRSGSFDIATAENVVICGSVSSA 118

Query: 160 XXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY 219
                  PY +SIEKVF+ GGG+IFRE LNAPGCEA+H TEI ASIECDTFMP VD + +
Sbjct: 119 MELLASSPYSMSIEKVFLTGGGEIFREALNAPGCEAVHITEIEASIECDTFMPRVDFSVF 178

Query: 220 QLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
             WYSSFP VEN+IRYSF TYVRV+SSA ESL QNTDP FD++SDSLKFEV+ F FLP+M
Sbjct: 179 HPWYSSFPLVENNIRYSFNTYVRVRSSAEESLGQNTDPSFDSDSDSLKFEVKKFSFLPKM 238

Query: 280 ILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           I + HEEY YLRL+QEIISE            LSKFGCQMRFNLRRSFP
Sbjct: 239 IFESHEEYKYLRLVQEIISEGTVKDDRTGTGTLSKFGCQMRFNLRRSFP 287


>M0ZJD1_SOLTU (tr|M0ZJD1) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Solanum tuberosum GN=PGSC0003DMG400000736
           PE=3 SV=1
          Length = 527

 Score =  373 bits (957), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 172/266 (64%), Positives = 210/266 (78%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QRTYQVVVAAT++MGIGK+GKLPWRL TDLKFFK IT  T+DP K+NA+VMGRKTWESIP
Sbjct: 21  QRTYQVVVAATQNMGIGKEGKLPWRLPTDLKFFKGITGTTTDPTKRNAVVMGRKTWESIP 80

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSIE VFVIGGG+
Sbjct: 81  IEHRPLPGRLNVVLTRSGSFDIATAENVVICGSLGSALQLLAASPYCLSIENVFVIGGGE 140

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           IFR+ LNA GC+A+H TEI   I CDTF P +D++ ++ WYSSFP +EN IRYSF TYVR
Sbjct: 141 IFRDSLNADGCDAVHITEIETDIACDTFTPAIDTSVFRPWYSSFPVIENKIRYSFTTYVR 200

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V++S  E+++Q+   + +N SDS   EV++F FLP+M+ ++HEE+MYLRL++EIIS    
Sbjct: 201 VKNSGVETVNQSNSEIPENGSDSSNIEVKSFSFLPKMVFEKHEEFMYLRLVEEIISNGML 260

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMR+NLRRSFP
Sbjct: 261 KDDRTGTGTLSKFGCQMRYNLRRSFP 286


>K4B3J6_SOLLC (tr|K4B3J6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Solanum lycopersicum GN=Solyc01g109830.2
           PE=3 SV=1
          Length = 527

 Score =  372 bits (956), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 173/266 (65%), Positives = 209/266 (78%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QRTYQVVVAAT+ MGIGK+GKLPWRL TDLKFFK IT  T+DP K+NA+VMGRKTWESIP
Sbjct: 21  QRTYQVVVAATQSMGIGKEGKLPWRLPTDLKFFKGITGTTTDPTKRNAVVMGRKTWESIP 80

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +++RPLPGRLNVVLTRSGSFDI TAENVVICGS+          PYCLSIE VFVIGGG+
Sbjct: 81  IEHRPLPGRLNVVLTRSGSFDIATAENVVICGSLGSALQLLASSPYCLSIENVFVIGGGE 140

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           IFR+ LNA GC+A+H TEI   I CDTF P +D++ ++ WYSSFP +EN IRYSF TYVR
Sbjct: 141 IFRDSLNAHGCDAVHITEIETDIACDTFTPAIDTSVFRPWYSSFPVIENKIRYSFTTYVR 200

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V++S  E+++Q+   + +N SDS   EV++F FLP+MI ++HEEYMYLRL+++IIS    
Sbjct: 201 VKNSGVETVNQSNSEIPENGSDSSDIEVKSFSFLPKMIFEKHEEYMYLRLVEDIISNGML 260

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMR+NLRRSFP
Sbjct: 261 KDDRTGTGTLSKFGCQMRYNLRRSFP 286


>B9RH79_RICCO (tr|B9RH79) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative OS=Ricinus communis GN=RCOM_1447960
           PE=3 SV=1
          Length = 528

 Score =  372 bits (955), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 174/266 (65%), Positives = 213/266 (80%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           +RTYQVVVAAT+DMGIGKDGKLPWRL +DLKFFK++T  T+D GKKNA++MGRKTWESIP
Sbjct: 22  RRTYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKDVTLTTTDSGKKNAVIMGRKTWESIP 81

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           L++RPLPGRLNVVLTRSGSFDI TAENVV+CGS           PYCLSIEKV+VIGGGQ
Sbjct: 82  LEHRPLPGRLNVVLTRSGSFDIATAENVVMCGSFASALELLAASPYCLSIEKVYVIGGGQ 141

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           I RE LNAPGC+A+H TEI  S +CDTF+P +DS+ +  WY SFP VEN+IRYSFATYVR
Sbjct: 142 ILREALNAPGCDAVHITEIETSFDCDTFIPAIDSSIFHPWYLSFPMVENNIRYSFATYVR 201

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+SSA ES   ++    +++S++ KF+V+ F FLP+M+  RHEE++YLRL+QEIIS+   
Sbjct: 202 VRSSAVESNGHDSGLSSESSSENSKFDVKKFSFLPKMVFDRHEEFLYLRLVQEIISDGIL 261

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQ+RFNLR++FP
Sbjct: 262 KDDRTGTGTLSKFGCQVRFNLRKTFP 287


>Q39687_DAUCA (tr|Q39687) Dihydrofolate reductase-thymidylate synthetase
           (Precursor) OS=Daucus carota GN=DHFR-TS PE=3 SV=2
          Length = 577

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 172/269 (63%), Positives = 208/269 (77%)

Query: 60  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 119
           P+ QRTYQVVVAAT++MGIGKDGKLPWRL +D+KFFK++T  TSDP K+NA++MGRKTWE
Sbjct: 67  PDPQRTYQVVVAATQNMGIGKDGKLPWRLPSDMKFFKDVTMTTSDPLKRNAVIMGRKTWE 126

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           SIP+++RPLPGRLNVVLTRSGSFDI T ENVVICGS+          PYC+S+EKVFVIG
Sbjct: 127 SIPIQHRPLPGRLNVVLTRSGSFDIATVENVVICGSMISALELLAGSPYCVSVEKVFVIG 186

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
           GGQI+RE LNAPGC+A+H TEI   IECDTF+P +D + +Q WYSSFP VEN IRY F T
Sbjct: 187 GGQIYREALNAPGCDAVHITEIEEHIECDTFIPLLDESVFQPWYSSFPLVENKIRYCFTT 246

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           YVRV++S AE  SQ      D+ SDS  FE+QNF FLP+ + ++HEEY+YL L++ IIS 
Sbjct: 247 YVRVRNSVAELTSQTNGCSSDSKSDSGNFEIQNFSFLPKTVFEKHEEYLYLGLVENIISN 306

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       +S FGCQMRFNLR+SFP
Sbjct: 307 GVTKNDRTRTGTVSIFGCQMRFNLRKSFP 335


>G7JHF2_MEDTR (tr|G7JHF2) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Medicago truncatula GN=MTR_4g070670 PE=3
           SV=1
          Length = 528

 Score =  370 bits (949), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 175/269 (65%), Positives = 209/269 (77%)

Query: 60  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 119
           PN QRTYQVVV AT+DMGI KDGKLPW L  D KFF++ITT TSDPGKKNA+VMGRK+WE
Sbjct: 19  PNPQRTYQVVVIATRDMGIAKDGKLPWTLPIDQKFFEDITTVTSDPGKKNAVVMGRKSWE 78

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           +IP + RPL GRLN++LTRSGSF+I TA+NV+ICGS+          PYC SIEKVF+ G
Sbjct: 79  AIPPENRPLRGRLNIILTRSGSFEIATADNVLICGSVSSAMELLASSPYCQSIEKVFLTG 138

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
           G +IFRE L+APGCEAIH TEI ASIECDTFMP +D + +  WY+SFP VEN IRYSF T
Sbjct: 139 GAEIFREALHAPGCEAIHITEIEASIECDTFMPRIDFSVFHPWYTSFPLVENGIRYSFNT 198

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           YVRV+SS  ES   NTDP+  +NS+ LKFE+++F FLP++I +RHEEY YL+L++EIISE
Sbjct: 199 YVRVRSSTEESQGLNTDPVLYDNSNPLKFEIKDFTFLPKIIFERHEEYKYLKLVEEIISE 258

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       LSKFG +MRFNLRRSFP
Sbjct: 259 GTVKDDRTGTGTLSKFGSKMRFNLRRSFP 287


>B9GCZ3_ORYSJ (tr|B9GCZ3) Putative uncharacterized protein OS=Oryza sativa subsp.
           japonica GN=OsJ_35972 PE=3 SV=1
          Length = 521

 Score =  369 bits (946), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 169/268 (63%), Positives = 206/268 (76%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           NL+R+YQVVV+AT+DMGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWES
Sbjct: 13  NLKRSYQVVVSATRDMGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWES 72

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IPLK+RPLPGRLNV+LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGG
Sbjct: 73  IPLKFRPLPGRLNVILTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGG 132

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           G+I R+ LNAP CEAIH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++
Sbjct: 133 GEILRQSLNAPACEAIHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISF 192

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV  S AE+   +   L  N+S  +KFE++NF FLP+MI +RHEEY YL L+Q+II   
Sbjct: 193 VRVTKSIAEANDSSGKELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNG 252

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      +SKFGCQMRFNLRR+FP
Sbjct: 253 AKKNDRTGTGTVSKFGCQMRFNLRRNFP 280


>C5Y2E9_SORBI (tr|C5Y2E9) Putative uncharacterized protein Sb05g016730 OS=Sorghum
           bicolor GN=Sb05g016730 PE=3 SV=1
          Length = 521

 Score =  365 bits (937), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 168/266 (63%), Positives = 202/266 (75%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  TSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLTTSDPAKKNAVIMGRKTWESIP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFV+GGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMNSALELLASTPYCLSIEKVFVVGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEAIH T+I +SIECDTF+PPVD + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ S AE+   N     + ++ + KFE++NF FLPEM+  RHEEY YL L+++II     
Sbjct: 195 VRKSVAETHESNGKESTEVDTKNDKFEIENFSFLPEMVYDRHEEYQYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    +SKFGCQMRFNLR++FP
Sbjct: 255 KNDRTGTGTMSKFGCQMRFNLRKNFP 280


>K3ZSB7_SETIT (tr|K3ZSB7) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Setaria italica GN=Si029497m.g PE=3 SV=1
          Length = 521

 Score =  364 bits (935), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 170/266 (63%), Positives = 202/266 (75%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T ATSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLATSDPAKKNAVIMGRKTWESIP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEAIH T+I +SIECDTF+PP+D + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNRPACEAIHLTDIQSSIECDTFIPPIDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ S AE+   N     + ++ + KFE +NF FLP+MI  RHEEY YL L+++II     
Sbjct: 195 VRKSLAETHESNGKESTEVDTKNDKFETENFSFLPKMIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR++FP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRKNFP 280


>K3ZSR0_SETIT (tr|K3ZSR0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Setaria italica GN=Si029497m.g PE=3 SV=1
          Length = 489

 Score =  364 bits (934), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 170/266 (63%), Positives = 202/266 (75%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T ATSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLATSDPAKKNAVIMGRKTWESIP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEAIH T+I +SIECDTF+PP+D + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNRPACEAIHLTDIQSSIECDTFIPPIDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ S AE+   N     + ++ + KFE +NF FLP+MI  RHEEY YL L+++II     
Sbjct: 195 VRKSLAETHESNGKESTEVDTKNDKFETENFSFLPKMIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR++FP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRKNFP 280


>J3ND79_ORYBR (tr|J3ND79) Uncharacterized protein OS=Oryza brachyantha
           GN=OB12G19370 PE=3 SV=1
          Length = 917

 Score =  359 bits (922), Expect = 7e-97,   Method: Compositional matrix adjust.
 Identities = 165/268 (61%), Positives = 201/268 (75%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           NLQ  YQVVVAAT DMGIGKDG LPW+L +DLKFFK+IT  TS+P KKNA+VMGRKTWES
Sbjct: 403 NLQTRYQVVVAATSDMGIGKDGVLPWKLPSDLKFFKDITMTTSNPSKKNAVVMGRKTWES 462

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP+++RPLPGRLN++LTRSGSFD  TAENVV CGS+          PYC ++EK+FVIGG
Sbjct: 463 IPIQFRPLPGRLNIILTRSGSFDFATAENVVTCGSLDSALELLSTTPYCSTVEKIFVIGG 522

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           G++ R+ LNAP CEAIH T+I +SI+CDTF+PP+D + +  WYSS+P VEN IR+SF T+
Sbjct: 523 GEVLRQSLNAPACEAIHLTDIESSIQCDTFIPPIDLSVFHPWYSSYPVVENSIRHSFITF 582

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV  S AE+   +   L  N+S   KFE++NF FLP++I QRHEEY YL L+Q+II   
Sbjct: 583 VRVTKSIAEANDSSGKELTGNDSKKNKFEIENFSFLPKVIFQRHEEYQYLNLVQDIIRNG 642

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       SKFGCQMRFNLRRSFP
Sbjct: 643 AKKNDRTGTGTTSKFGCQMRFNLRRSFP 670


>B8BKI9_ORYSI (tr|B8BKI9) Putative uncharacterized protein OS=Oryza sativa subsp.
           indica GN=OsI_36122 PE=4 SV=1
          Length = 404

 Score =  359 bits (922), Expect = 7e-97,   Method: Compositional matrix adjust.
 Identities = 165/266 (62%), Positives = 198/266 (74%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEA+H T+I +SIECDTF+PP+D + +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR SFP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFP 280


>Q2R481_ORYSJ (tr|Q2R481) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative, expressed OS=Oryza sativa subsp.
           japonica GN=LOC_Os11g29390 PE=2 SV=1
          Length = 521

 Score =  358 bits (918), Expect = 2e-96,   Method: Compositional matrix adjust.
 Identities = 165/266 (62%), Positives = 198/266 (74%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEA+H T+I +SIECDTF+PP+D + +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR SFP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFP 280


>K3ZI20_SETIT (tr|K3ZI20) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Setaria italica GN=Si026222m.g PE=3 SV=1
          Length = 521

 Score =  358 bits (918), Expect = 2e-96,   Method: Compositional matrix adjust.
 Identities = 166/266 (62%), Positives = 199/266 (74%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T +TSDP KKNA++MGRKTWESIP
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKEVTLSTSDPAKKNAVIMGRKTWESIP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYC+SIEKVFVIGGGQ
Sbjct: 75  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCVSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEAIH T++ +SIECDTF+PP+D + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 135 VLREYLNGPACEAIHLTDVQSSIECDTFIPPIDFSVFQPWYSSFPVVESNIRHSFVTFVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ S  E+   N     + ++ + KFE +NF FLP+MI  RHEEY YL L ++II     
Sbjct: 195 VRKSLEETHVSNGKESTEVDTKNDKFETENFSFLPKMIFDRHEEYHYLNLAEDIIKSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR+ FP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRKIFP 280


>B9GAQ2_ORYSJ (tr|B9GAQ2) Putative uncharacterized protein OS=Oryza sativa subsp.
           japonica GN=OsJ_33908 PE=2 SV=1
          Length = 574

 Score =  358 bits (918), Expect = 2e-96,   Method: Compositional matrix adjust.
 Identities = 165/266 (62%), Positives = 198/266 (74%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEA+H T+I +SIECDTF+PP+D + +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR SFP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFP 280


>B6UD82_MAIZE (tr|B6UD82) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Zea mays PE=2 SV=1
          Length = 523

 Score =  357 bits (916), Expect = 4e-96,   Method: Compositional matrix adjust.
 Identities = 167/266 (62%), Positives = 200/266 (75%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT DMGIGK G LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWESIP
Sbjct: 17  QRNYQVVVAATCDMGIGKGGVLPWKLLGDLKFFKELTLTTTDPAKKNAVIMGRKTWESIP 76

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 77  VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 136

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + R+ LN P CEAIH T+I +SIECDTF+PPVD + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 137 VLRDYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNIRHSFVTFVR 196

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ S AE+   N   L + ++ + KFE++NF FLP+M+  RHEEY YL L+++II     
Sbjct: 197 VRKSVAETHESNGKELTEIDTKNDKFEIENFSFLPKMVHDRHEEYQYLNLVEDIIRFGAQ 256

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR+ FP
Sbjct: 257 KNDRTGTGTLSKFGCQMRFNLRKIFP 282


>K7UAA2_MAIZE (tr|K7UAA2) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Zea mays GN=ZEAMMB73_916665 PE=3 SV=1
          Length = 562

 Score =  357 bits (915), Expect = 4e-96,   Method: Compositional matrix adjust.
 Identities = 165/266 (62%), Positives = 201/266 (75%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGK G +PW+L  DLKFFKE+T  T+DP KKNA++MGRKTWESIP
Sbjct: 56  QRNYQVVVAATRDMGIGKGGVMPWKLLGDLKFFKELTLTTTDPAKKNAVIMGRKTWESIP 115

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 116 VKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIEKVFVIGGGQ 175

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEAIH T+I +SIECDTF+PPVD + +Q WYSSFP VE++IR+SF T+VR
Sbjct: 176 VLREYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNIRHSFVTFVR 235

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ S AE+   N     + ++ + KFE++NF FLP+++  RHEEY YL L+++II     
Sbjct: 236 VRKSVAETHESNGKESTEIDTKNDKFEIENFSFLPKIVYDRHEEYQYLNLVEDIIRFGAQ 295

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR++FP
Sbjct: 296 KNDRTGTGTLSKFGCQMRFNLRKNFP 321


>I1R077_ORYGL (tr|I1R077) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Oryza glaberrima PE=3 SV=1
          Length = 521

 Score =  357 bits (915), Expect = 4e-96,   Method: Compositional matrix adjust.
 Identities = 165/266 (62%), Positives = 197/266 (74%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAAT+DMGIGKDG LPW+L  DLKFFKE+T  T+DP KKNA++MGRKTWES+P
Sbjct: 15  QRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLP 74

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           LK RPLPGRLN++LTRSGSF+  T ENVVICGS+          PYCLSIEKVFVIGGGQ
Sbjct: 75  LKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQ 134

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LN P CEA+H T+I +SIECDTF+PP+D   +Q WYSS P VE++IR+SF TYVR
Sbjct: 135 VLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLLVFQPWYSSLPVVESNIRHSFVTYVR 194

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+ + AE+   N     ++   S KFE +NF FLP++I  RHEEY YL L+++II     
Sbjct: 195 VRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYHYLNLVEDIIRSGAQ 254

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR SFP
Sbjct: 255 KNDRTGTGTLSKFGCQMRFNLRNSFP 280


>J3MF38_ORYBR (tr|J3MF38) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Oryza brachyantha GN=OB06G26320 PE=3 SV=1
          Length = 521

 Score =  357 bits (915), Expect = 4e-96,   Method: Compositional matrix adjust.
 Identities = 162/268 (60%), Positives = 203/268 (75%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           N+Q  YQVVVAAT+DMGIGKDG LPW++ +DLKFFK+IT  TS+P KKNA+VMGRKTWES
Sbjct: 13  NVQTRYQVVVAATRDMGIGKDGVLPWKVPSDLKFFKDITMTTSNPSKKNAVVMGRKTWES 72

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP+++RPLPGRLN++LTRSGSFD  TAENVV CGS+          PYC ++EK+FVIGG
Sbjct: 73  IPIQFRPLPGRLNIILTRSGSFDFATAENVVTCGSLDSALELLSTTPYCSTVEKIFVIGG 132

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           G++ R+ LNAP CEAIH T+I +S+ECDTF+PP+D + +  WYSS+P VEN IR+SF T+
Sbjct: 133 GEVLRQSLNAPACEAIHLTDIESSVECDTFIPPIDLSVFHPWYSSYPVVENSIRHSFITF 192

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV  S AE+   +   L  N+S   KFE++NF FLP++I +RHEEY YL L+Q+II   
Sbjct: 193 VRVTKSIAEANDSSGKELTGNDSKKNKFEIENFSFLPKVIFERHEEYQYLNLVQDIIRNG 252

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      +SKFGCQMRFNLRRSFP
Sbjct: 253 AKKNDRTGTGTISKFGCQMRFNLRRSFP 280


>I1IIJ7_BRADI (tr|I1IIJ7) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brachypodium distachyon GN=BRADI4G07810 PE=3
           SV=1
          Length = 517

 Score =  350 bits (899), Expect = 3e-94,   Method: Compositional matrix adjust.
 Identities = 161/269 (59%), Positives = 200/269 (74%), Gaps = 5/269 (1%)

Query: 60  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 119
           P+++R YQVVVAAT +MGIGKDG LPW+L +DL FFKE+T ATSDP KKNA++MGRKTWE
Sbjct: 13  PDIRRNYQVVVAATHEMGIGKDGALPWKLPSDLNFFKELTMATSDPSKKNAVIMGRKTWE 72

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           SIP K+RPLPGRLNV+LTRSGSFD  T ENVVICGS+          PY L+IEK F+IG
Sbjct: 73  SIPAKFRPLPGRLNVILTRSGSFDFATVENVVICGSLDSSLELLASTPYSLTIEKAFLIG 132

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
           GGQ+ R+ LNAP CEAIH T+I ++IECDT++PP+D + +  WYSSFP VEN+IR+SF T
Sbjct: 133 GGQVLRDSLNAPACEAIHLTDIESTIECDTYIPPIDLSVFHPWYSSFPVVENNIRHSFVT 192

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           +VRV+    E    N      N++   +FE++NF FLP+MI +RH+EY YL L+Q+II  
Sbjct: 193 FVRVRKPVTEVNDSNG-----NDAKKERFEIKNFSFLPKMIFERHDEYQYLNLVQDIIQS 247

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       LSKFGCQMRFNLRR+FP
Sbjct: 248 GARKNDRTGTGTLSKFGCQMRFNLRRNFP 276


>M7YZH3_TRIUA (tr|M7YZH3) Putative bifunctional dihydrofolate
           reductase-thymidylate synthase OS=Triticum urartu
           GN=TRIUR3_06844 PE=4 SV=1
          Length = 520

 Score =  349 bits (895), Expect = 9e-94,   Method: Compositional matrix adjust.
 Identities = 159/268 (59%), Positives = 200/268 (74%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T AT+DP KKNA++MGRKTWES
Sbjct: 12  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATADPSKKNAVIMGRKTWES 71

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP K+RPLPGRLNV+LTRSGS D  T ENVV CGS+          PY  +IEK F+IGG
Sbjct: 72  IPTKFRPLPGRLNVILTRSGSSDYATVENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 131

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           GQ+ RE LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 132 GQVLRESLNASACEAIHLTDIESTIECDTFIPPIDPLVFHPWYSSSPVVENNIRHSFATF 191

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV+ SA E+   N   L  N++   KFE+QNF FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 192 VRVRKSAEEANDSNPSELTSNDAKKEKFEIQNFSFLPKMIFEKHDEYQYLNLVQDILRSG 251

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      +SKFGCQMRFNLR++FP
Sbjct: 252 ARKNDRTGTGTISKFGCQMRFNLRKNFP 279


>B8BPG2_ORYSI (tr|B8BPG2) Putative uncharacterized protein OS=Oryza sativa subsp.
           indica GN=OsI_38205 PE=3 SV=1
          Length = 494

 Score =  344 bits (883), Expect = 2e-92,   Method: Compositional matrix adjust.
 Identities = 158/253 (62%), Positives = 191/253 (75%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWESIPLK+RPLPGRLNV+
Sbjct: 1   MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGGG+I R+ LNAP CEA
Sbjct: 61  LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120

Query: 196 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 255
           IH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++VRV  S AE+   + 
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180

Query: 256 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 315
             L  N+S  +KFE++NF FLP+MI +RHEEY YL L+Q+II              +SKF
Sbjct: 181 KELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240

Query: 316 GCQMRFNLRRSFP 328
           GCQMRFNLRR+FP
Sbjct: 241 GCQMRFNLRRNFP 253


>B7FA29_ORYSJ (tr|B7FA29) cDNA, clone: J100037K11, full insert sequence OS=Oryza
           sativa subsp. japonica PE=2 SV=1
          Length = 494

 Score =  344 bits (883), Expect = 2e-92,   Method: Compositional matrix adjust.
 Identities = 158/253 (62%), Positives = 191/253 (75%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWESIPLK+RPLPGRLNV+
Sbjct: 1   MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGGG+I R+ LNAP CEA
Sbjct: 61  LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120

Query: 196 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 255
           IH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++VRV  S AE+   + 
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180

Query: 256 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 315
             L  N+S  +KFE++NF FLP+MI +RHEEY YL L+Q+II              +SKF
Sbjct: 181 KELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240

Query: 316 GCQMRFNLRRSFP 328
           GCQMRFNLRR+FP
Sbjct: 241 GCQMRFNLRRNFP 253


>R7WB22_AEGTA (tr|R7WB22) Putative bifunctional dihydrofolate
           reductase-thymidylate synthase OS=Aegilops tauschii
           GN=F775_09243 PE=4 SV=1
          Length = 520

 Score =  344 bits (882), Expect = 3e-92,   Method: Compositional matrix adjust.
 Identities = 157/268 (58%), Positives = 199/268 (74%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T AT+DP KKNA++MGRKTWES
Sbjct: 12  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATADPSKKNAVIMGRKTWES 71

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP K+RPLPGRLNV+LTRS S D  T ENVV CGS+          PY  +IEK F+IGG
Sbjct: 72  IPTKFRPLPGRLNVILTRSDSSDYATVENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 131

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           GQ+ RE+LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 132 GQVLRELLNASACEAIHLTDIESTIECDTFIPPIDPLVFHPWYSSSPVVENNIRHSFATF 191

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV+ SA E+   N   L  N++   KFE+Q F FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 192 VRVRKSAEEANDSNLSELTSNDAKKKKFEIQIFSFLPKMIFEKHDEYQYLNLVQDILRSG 251

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      +SKFGCQMRFNLR++FP
Sbjct: 252 ARKNDRTGTGTISKFGCQMRFNLRKNFP 279


>F6H1I8_VITVI (tr|F6H1I8) Putative uncharacterized protein OS=Vitis vinifera
           GN=VIT_18s0001g12940 PE=3 SV=1
          Length = 502

 Score =  343 bits (881), Expect = 4e-92,   Method: Compositional matrix adjust.
 Identities = 164/253 (64%), Positives = 192/253 (75%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIGKDGKLPW L +DLKFFKE+T  TSDPGKKNA+VMGRKTWESIPL YRPLPGRLNVV
Sbjct: 1   MGIGKDGKLPWNLPSDLKFFKELTMTTSDPGKKNAVVMGRKTWESIPLNYRPLPGRLNVV 60

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           LTRSGSFD  T ENVVICGS+          PYCLSI+KVFVIGGGQI RE LNAPGC+A
Sbjct: 61  LTRSGSFDNATVENVVICGSMPSALKLLAESPYCLSIDKVFVIGGGQILREALNAPGCDA 120

Query: 196 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 255
           IH T+I  SIECDTF+P +D++ +  WYSS P +EN+I YSF TYVRV+SSA ES + ++
Sbjct: 121 IHITKIETSIECDTFIPTIDTSVFHPWYSSVPLLENNILYSFVTYVRVRSSALESFALSS 180

Query: 256 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 315
              F+  S   K ++Q F FLP+MI +RH+E+MYLR ++EIIS             +SKF
Sbjct: 181 GVNFNGGSVPNKLKIQGFTFLPKMIFERHDEFMYLRQLKEIISSGAHKADKTGTGTVSKF 240

Query: 316 GCQMRFNLRRSFP 328
           GCQMRFNLR SFP
Sbjct: 241 GCQMRFNLRLSFP 253


>I1R663_ORYGL (tr|I1R663) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Oryza glaberrima PE=3 SV=1
          Length = 494

 Score =  343 bits (879), Expect = 7e-92,   Method: Compositional matrix adjust.
 Identities = 157/253 (62%), Positives = 191/253 (75%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIGKDG LPW+L  DLKFFK+IT  TSDP KKNA+VMGRKTWESIPLK+RPLPGRLNV+
Sbjct: 1   MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           LTRSGSFD  TAENVVICGS+          PYCL++EK F+IGGG+I R+ LNAP CEA
Sbjct: 61  LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120

Query: 196 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 255
           IH T+I +SIECDTF+PP+D + +  WYSSFP VEN I++SF ++VRV  S AE+   + 
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSIFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180

Query: 256 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 315
             L  N+S  +KF+++NF FLP+MI +RHEEY YL L+Q+II              +SKF
Sbjct: 181 KELTGNDSKKVKFQIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240

Query: 316 GCQMRFNLRRSFP 328
           GCQMRFNLRR+FP
Sbjct: 241 GCQMRFNLRRNFP 253


>B9R7Y4_RICCO (tr|B9R7Y4) Bifunctional dihydrofolate reductase-thymidylate
           synthase, putative OS=Ricinus communis GN=RCOM_1595270
           PE=3 SV=1
          Length = 591

 Score =  340 bits (872), Expect = 5e-91,   Method: Compositional matrix adjust.
 Identities = 165/266 (62%), Positives = 198/266 (74%), Gaps = 2/266 (0%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
            R YQVVVAAT+DMGIGKDGKLPWRL +DLKFFKE+T  TS PGK+NA+VMGRKTWESIP
Sbjct: 84  NRRYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKELTLTTSSPGKRNAVVMGRKTWESIP 143

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           LKYRPLPGRLN+VLT SG  DI TAE+V+ CGSI          PY   IEKVF IGGGQ
Sbjct: 144 LKYRPLPGRLNIVLTCSGGCDITTAEDVLTCGSIPSALELLAEAPYSFLIEKVFFIGGGQ 203

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           I R+ +NAPGC+AIH TEI  SIECDTF+P +D + +  WYSS P VEN++RYSFATYVR
Sbjct: 204 ILRKTINAPGCDAIHITEIETSIECDTFIPVIDFSLFHPWYSSLPIVENNVRYSFATYVR 263

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V++S   +LS++     + N  S  FEV+NF FLP +I ++H+EYMYLRL ++IIS    
Sbjct: 264 VKNSENGTLSKSASA--NGNLSSNTFEVKNFTFLPSIIYKKHDEYMYLRLAEQIISNGTL 321

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFG QM++NLR+SFP
Sbjct: 322 KDDRTGTGTLSKFGGQMQYNLRKSFP 347


>M0YHZ0_HORVD (tr|M0YHZ0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Hordeum vulgare var. distichum PE=3 SV=1
          Length = 572

 Score =  339 bits (870), Expect = 7e-91,   Method: Compositional matrix adjust.
 Identities = 158/268 (58%), Positives = 198/268 (73%), Gaps = 5/268 (1%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T ATSDP KKNA++MGRKTWES
Sbjct: 69  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATSDPSKKNAVIMGRKTWES 128

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP K+RPLPGRLNV+LTRSGS D   AENVV CGS+          PY  +IEK F+IGG
Sbjct: 129 IPTKFRPLPGRLNVILTRSGSSDYAKAENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 188

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           GQ+ RE LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 189 GQVLRESLNASACEAIHLTDIESTIECDTFIPPIDPLIFHPWYSSSPVVENNIRHSFATF 248

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV+ SA E+   N      N++   KFE+Q F FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 249 VRVRKSAEEANDPNV-----NDTKKEKFEIQIFSFLPKMIFEKHDEYQYLNLVQDILRTG 303

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      +SKFGCQMRFNLR++FP
Sbjct: 304 ARKNDRTGTGTISKFGCQMRFNLRKNFP 331


>D7L1V0_ARALL (tr|D7L1V0) Dihydrofolate reductase-thymidylate synthase
           OS=Arabidopsis lyrata subsp. lyrata GN=ARALYDRAFT_480800
           PE=3 SV=1
          Length = 515

 Score =  339 bits (869), Expect = 9e-91,   Method: Compositional matrix adjust.
 Identities = 164/266 (61%), Positives = 193/266 (72%), Gaps = 10/266 (3%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QRTYQVVVAATK+MGIGKDGKLPW L TDLKFFK+IT  TSD  KKNA+VMGRKTWE+IP
Sbjct: 19  QRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSDSSKKNAVVMGRKTWEAIP 78

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +K+RPL GRLNVVLTRSG FDI   ENVV C S+          PYCLSIE+VFVIGGG 
Sbjct: 79  IKHRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLAAPPYCLSIERVFVIGGGD 138

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           I RE LN P C+AIH TEI  SIECDTF+P VD++ YQ W SSFP  EN +R+ F T+VR
Sbjct: 139 ILREALNRPSCDAIHLTEIDTSIECDTFIPAVDTSVYQPWCSSFPVTENGLRFCFTTFVR 198

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           V+SS  ES          N S SL+F+ + F FLP+M+  +HEE++YL ++++IIS    
Sbjct: 199 VKSSTDES----------NVSQSLQFDGKKFLFLPKMVFDQHEEFLYLNMVEDIISNGNA 248

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQM+FNLRRSFP
Sbjct: 249 KNDRTGTGTLSKFGCQMKFNLRRSFP 274


>F2DUZ4_HORVD (tr|F2DUZ4) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Hordeum vulgare var. distichum PE=2 SV=1
          Length = 516

 Score =  338 bits (868), Expect = 1e-90,   Method: Compositional matrix adjust.
 Identities = 158/268 (58%), Positives = 198/268 (73%), Gaps = 5/268 (1%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           ++QR YQVVVAAT++MGIGKDG LPW+L +DLKFFK++T ATSDP KKNA++MGRKTWES
Sbjct: 13  DIQRKYQVVVAATREMGIGKDGALPWKLPSDLKFFKDLTMATSDPSKKNAVIMGRKTWES 72

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP K+RPLPGRLNV+LTRSGS D   AENVV CGS+          PY  +IEK F+IGG
Sbjct: 73  IPTKFRPLPGRLNVILTRSGSSDYAKAENVVTCGSLDSSLELLASAPYSSTIEKAFLIGG 132

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           GQ+ RE LNA  CEAIH T+I ++IECDTF+PP+D   +  WYSS P VEN+IR+SFAT+
Sbjct: 133 GQVLRESLNASACEAIHLTDIESTIECDTFIPPIDPLIFHPWYSSSPVVENNIRHSFATF 192

Query: 241 VRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           VRV+ SA E+   N      N++   KFE+Q F FLP+MI ++H+EY YL L+Q+I+   
Sbjct: 193 VRVRKSAEEANDPNV-----NDTKKEKFEIQIFSFLPKMIFEKHDEYQYLNLVQDILRTG 247

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      +SKFGCQMRFNLR++FP
Sbjct: 248 ARKNDRTGTGTISKFGCQMRFNLRKNFP 275


>M4D9B9_BRARP (tr|M4D9B9) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brassica rapa subsp. pekinensis GN=Bra013079
           PE=3 SV=1
          Length = 618

 Score =  335 bits (860), Expect = 1e-89,   Method: Compositional matrix adjust.
 Identities = 163/269 (60%), Positives = 190/269 (70%), Gaps = 6/269 (2%)

Query: 60  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 119
           P+ QRTYQVVVAATK MGIGKDGKLPW L TDLKFFK+IT  TSDP KKNA+VMGRKTWE
Sbjct: 12  PDPQRTYQVVVAATKQMGIGKDGKLPWNLPTDLKFFKDITQTTSDPTKKNAVVMGRKTWE 71

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           +IP K+RPLPGRLNVVLTRSG FDI   ENVV C S+          PYCLSIE+VFVIG
Sbjct: 72  AIPTKHRPLPGRLNVVLTRSGGFDIANTENVVTCSSVDSALHLLAAPPYCLSIERVFVIG 131

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
           GG I RE LN P C+AIH TEI  SIECDTF+P VD+  YQ W SS P  EN +R+ F +
Sbjct: 132 GGDILREALNMPSCDAIHLTEIDTSIECDTFIPEVDTCVYQPWCSSVPVTENGLRFRFTS 191

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           +VRV+SSA ES S  +          L+F+ + F FLP+M+  +HEE+ YL ++ +IIS 
Sbjct: 192 FVRVKSSADESSSNGS------QQSPLQFDGKRFSFLPKMVFDQHEEFRYLNMVGDIISN 245

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       LSKFG QM+FNLRRSFP
Sbjct: 246 GNVKNDRTGTGTLSKFGTQMKFNLRRSFP 274


>R0HKJ0_9BRAS (tr|R0HKJ0) Uncharacterized protein (Fragment) OS=Capsella rubella
           GN=CARUB_v10013341mg PE=4 SV=1
          Length = 569

 Score =  333 bits (855), Expect = 4e-89,   Method: Compositional matrix adjust.
 Identities = 164/270 (60%), Positives = 197/270 (72%), Gaps = 6/270 (2%)

Query: 59  LPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTW 118
           +P  QRTYQVVVAATK+MGIGKDG LPW L TDLKFFK++T  TSD  KKNA+VMGRKTW
Sbjct: 65  VPEPQRTYQVVVAATKEMGIGKDGNLPWNLPTDLKFFKDVTLTTSDSSKKNAVVMGRKTW 124

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVI 178
           ESIP+K+RPL GRLNVVLTRSG FDI   ENVV C S+          PYCLSIE+VFVI
Sbjct: 125 ESIPIKHRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLALPPYCLSIERVFVI 184

Query: 179 GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFA 238
           GGG I RE LN P C+AIH TEI  SIECDTF+P +D++ YQ WYSSFP  EN +R+ F 
Sbjct: 185 GGGDILREALNRPSCDAIHLTEIDTSIECDTFIPAIDTSVYQPWYSSFPITENGLRFCFT 244

Query: 239 TYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIIS 298
           T+VRV+SSA ES  ++      N   SL+F+ + F FLP+M+  +HEE++YL ++++IIS
Sbjct: 245 TFVRVRSSADESSDES------NGLQSLQFDGKKFSFLPKMVFDQHEEFLYLNMVEDIIS 298

Query: 299 EXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                        LSKFGCQM+FNLRRSFP
Sbjct: 299 NGNIKNDRTGTGTLSKFGCQMKFNLRRSFP 328


>D7MEC7_ARALL (tr|D7MEC7) Predicted protein OS=Arabidopsis lyrata subsp. lyrata
           GN=ARALYDRAFT_656540 PE=3 SV=1
          Length = 565

 Score =  328 bits (840), Expect = 2e-87,   Method: Compositional matrix adjust.
 Identities = 165/267 (61%), Positives = 189/267 (70%), Gaps = 6/267 (2%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           Q TYQVVVAATK+MGIGKDGKLPW L TDLKFFK++T  TSD  KKNA+VMGRKTWESIP
Sbjct: 63  QSTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDLTLTTSDSAKKNAVVMGRKTWESIP 122

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            KYRPL GRLNVVLTRS   DI   ENVV C SI          P+ LSIEKVFVIGGG 
Sbjct: 123 TKYRPLSGRLNVVLTRSSGVDIANTENVVTCSSIDSALDLLAAPPFSLSIEKVFVIGGGD 182

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           I RE LN P CEAIH TEI  SI+CDTF+P VD++ YQ W SSFP  EN +R+SF TYVR
Sbjct: 183 ILREALNGPSCEAIHLTEIDTSIDCDTFIPAVDTSAYQPWCSSFPICENGLRFSFTTYVR 242

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNF-DFLPEMILQRHEEYMYLRLIQEIISEXX 301
           V+SS+A   S  +D      S  L+ + + F  FLP+MI  RHEE++YL L++EIIS   
Sbjct: 243 VKSSSACESSDVSD-----GSKVLQVDWKKFSSFLPKMIFDRHEEFLYLNLVKEIISNGN 297

Query: 302 XXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                     LSKFGCQM+FNLRR+FP
Sbjct: 298 LKGDRTGTGTLSKFGCQMKFNLRRNFP 324


>R0F3G9_9BRAS (tr|R0F3G9) Uncharacterized protein OS=Capsella rubella
           GN=CARUB_v10004370mg PE=4 SV=1
          Length = 628

 Score =  322 bits (824), Expect = 1e-85,   Method: Compositional matrix adjust.
 Identities = 162/268 (60%), Positives = 190/268 (70%), Gaps = 7/268 (2%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           LQRTYQVVVAATK+MGIGKDGKLPW L +DLKFFK++T  TSD  KKNA+VMGRKTWESI
Sbjct: 126 LQRTYQVVVAATKEMGIGKDGKLPWNLPSDLKFFKDLTLTTSDSAKKNAVVMGRKTWESI 185

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P KYRPL GRLN+VLTRS   +I   ENVV C SI          PY +SI+KVFVIGGG
Sbjct: 186 PSKYRPLCGRLNIVLTRSSGSNIANTENVVTCSSIDSALDLLAAPPYSMSIDKVFVIGGG 245

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
            I RE LN P CEAIH TEI  SI+CDTF+PP+D++ YQ WYSSFP  EN +RYSF T+V
Sbjct: 246 DILRESLNRPRCEAIHLTEIDKSIDCDTFIPPIDTSAYQPWYSSFPICENGLRYSFTTFV 305

Query: 242 RVQSSAA-ESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEX 300
           RV+SS+A ES  +  +      S +L    +   FLP+MI  RHEE +YL L++EIIS  
Sbjct: 306 RVKSSSAGESFKERAE------SHALVDWKKFSSFLPKMIFDRHEELLYLNLVKEIISNG 359

Query: 301 XXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       SKFGCQM+FNLRR+FP
Sbjct: 360 NLKNDRTGTGTFSKFGCQMKFNLRRNFP 387


>K7TWH4_MAIZE (tr|K7TWH4) Uncharacterized protein OS=Zea mays GN=ZEAMMB73_826351
           PE=4 SV=1
          Length = 300

 Score =  318 bits (814), Expect = 2e-84,   Method: Compositional matrix adjust.
 Identities = 149/253 (58%), Positives = 182/253 (71%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIGKDG LPW+L  DLKFFKE+T  TSD  KKNA++M RKTWESIP+K RPLPGRLNV+
Sbjct: 1   MGIGKDGVLPWKLPGDLKFFKELTLTTSDLVKKNAVIMERKTWESIPVKSRPLPGRLNVI 60

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           LTRSG+FD  T ENVVICGS+          PYCLSIEKVFVIGGGQ+ RE L  P CEA
Sbjct: 61  LTRSGTFDFATVENVVICGSMESALELLASTPYCLSIEKVFVIGGGQVLREYLKGPACEA 120

Query: 196 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNT 255
           IH T+I +SIEC TF+PPVD + +Q WYSSFP +E++IR+ F ++VRV+ S AE+   N 
Sbjct: 121 IHLTDIQSSIECVTFIPPVDFSVFQPWYSSFPVIESNIRHLFVSFVRVRKSVAETHESNG 180

Query: 256 DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKF 315
               + ++ + KFE +NF FLP+M+  RHEEY YL L+++II              LSKF
Sbjct: 181 KESTEVDTKNDKFEKENFSFLPKMVYDRHEEYQYLNLVEDIIRSGAQKNDRTGTGTLSKF 240

Query: 316 GCQMRFNLRRSFP 328
           GCQMRFNLR+  P
Sbjct: 241 GCQMRFNLRKKIP 253


>M4D4Y6_BRARP (tr|M4D4Y6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brassica rapa subsp. pekinensis GN=Bra011543
           PE=3 SV=1
          Length = 499

 Score =  315 bits (808), Expect = 1e-83,   Method: Compositional matrix adjust.
 Identities = 158/267 (59%), Positives = 184/267 (68%), Gaps = 15/267 (5%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QR YQVVVAATK+MGIGKDGKLPW L TDLKFFKE+T  TSD  KKNA+VMGRKTWESIP
Sbjct: 6   QRAYQVVVAATKEMGIGKDGKLPWSLPTDLKFFKELTLTTSDSSKKNAVVMGRKTWESIP 65

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            KY+PL GRLNVVLTRS  FDI  AENVV C SI          PY LSIEKVFVIGGG+
Sbjct: 66  TKYKPLSGRLNVVLTRSSGFDIANAENVVTCRSIDSALDLLAGPPYRLSIEKVFVIGGGE 125

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + R+ LN P CEAIH TEI  S+ECDTF+P +DS+ YQ W SS P  EN +R+SF TYVR
Sbjct: 126 VLRDSLNGPRCEAIHLTEIDTSVECDTFVPEIDSSAYQPWCSSLPVCENGLRFSFTTYVR 185

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNF-DFLPEMILQRHEEYMYLRLIQEIISEXX 301
           V+S              D + ++L  + + F   LP+ + +RHEE++YL ++ EIIS   
Sbjct: 186 VKS--------------DESKEALGVDWRKFSSLLPKKVFERHEEFLYLNMVNEIISSGN 231

Query: 302 XXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                     LSKFGCQM FNLRRSFP
Sbjct: 232 VKNDRTGTGTLSKFGCQMTFNLRRSFP 258


>B9H4E7_POPTR (tr|B9H4E7) Dihydrofolate reductase-thymidylate synthase OS=Populus
           trichocarpa GN=DHFR-TS-3b PE=3 SV=1
          Length = 283

 Score =  307 bits (786), Expect = 3e-81,   Method: Compositional matrix adjust.
 Identities = 148/227 (65%), Positives = 178/227 (78%), Gaps = 3/227 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R+YQVVVAAT+DMGIGKDGKLPWRL +DLKFFKE+T ATSDPGK+NAI+MGRKTWESIP+
Sbjct: 53  RSYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKEVTLATSDPGKQNAILMGRKTWESIPI 112

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           KYRPLP RLNVVLTRS  F+I   ENV+ CGSI          PYC SI+KVFVIGGGQI
Sbjct: 113 KYRPLPDRLNVVLTRS--FEIEDEENVITCGSISSALELLAETPYCFSIDKVFVIGGGQI 170

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
            RE LN PGC+AIH TEI +S+ECDTF+P +D +K+Q WYSS P VEN  RYSF TYV V
Sbjct: 171 LRETLNGPGCDAIHVTEIESSVECDTFIPSIDFSKFQPWYSSPPLVENGFRYSFVTYVHV 230

Query: 244 QSSAAESLSQNT-DPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMY 289
           ++S  E+++  T     D  S+S +FEV++F FLP+MI ++ EEYM+
Sbjct: 231 RNSENETIAGKTGGKCNDVKSNSNRFEVKDFSFLPKMIFEKGEEYMH 277


>M4DMC9_BRARP (tr|M4DMC9) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Brassica rapa subsp. pekinensis GN=Bra017662
           PE=3 SV=1
          Length = 504

 Score =  287 bits (734), Expect = 4e-75,   Method: Compositional matrix adjust.
 Identities = 150/266 (56%), Positives = 182/266 (68%), Gaps = 16/266 (6%)

Query: 65  TYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-KKNAIVMGRKTWESIPL 123
           +YQVVVAATK+MGIGKDGKLPW L TDLKFFK++T  TSD   KKNA+VMGR+TWESIP 
Sbjct: 12  SYQVVVAATKEMGIGKDGKLPWTLPTDLKFFKDLTLTTSDSTTKKNAVVMGRRTWESIPA 71

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           K+RPL GRLNVVLTRS  F+I  AENVV C S+          PY LSIEKVFVIGGG++
Sbjct: 72  KHRPLSGRLNVVLTRSSGFEIANAENVVTCRSLDSALELLAGPPYSLSIEKVFVIGGGEV 131

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
            R+ LN   CEAIH TEI   IECDTF+P VD++ YQ W SS P  EN +R++F TYVRV
Sbjct: 132 LRDSLNGARCEAIHLTEIDTCIECDTFVPAVDASAYQPWCSSLPMCENGVRFAFTTYVRV 191

Query: 244 QSSAAESLSQNTDPLFDNNSDSLKFEVQNF-DFLPEMILQRHEEYMYLRLIQEIISEXXX 302
           +S              D + ++L+ + + F   LP+ + +RHEE++YL L+ EIIS    
Sbjct: 192 KS--------------DESKEALQVDWKKFSSLLPKKVFERHEEFLYLNLVDEIISSGNL 237

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    +SKFGCQM FNLRRSFP
Sbjct: 238 KNDRTGTGTVSKFGCQMTFNLRRSFP 263


>M0S7X1_MUSAM (tr|M0S7X1) Uncharacterized protein OS=Musa acuminata subsp.
           malaccensis PE=4 SV=1
          Length = 505

 Score =  287 bits (734), Expect = 4e-75,   Method: Compositional matrix adjust.
 Identities = 129/181 (71%), Positives = 151/181 (83%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           QRTYQVVVAAT+DMGIGKDG LPW+L +DLKFFKE+T  TSDP K+NA++MGRKTWESIP
Sbjct: 19  QRTYQVVVAATRDMGIGKDGNLPWKLPSDLKFFKEVTMTTSDPSKRNAVIMGRKTWESIP 78

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            + RPLPGRLNVVLTRSGSFDI TAEN+++CGS+          PYCLSIE+VFVIGGGQ
Sbjct: 79  PRNRPLPGRLNVVLTRSGSFDIATAENILMCGSLNSALELLAATPYCLSIERVFVIGGGQ 138

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + RE LNAPGCEAIH T+I  S +CDTF+PPVD + ++ WYSSFP +EN IRYSF TYVR
Sbjct: 139 VLREALNAPGCEAIHLTDIETSFQCDTFIPPVDCSVFRPWYSSFPLLENSIRYSFVTYVR 198

Query: 243 V 243
           +
Sbjct: 199 I 199


>B9H4E4_POPTR (tr|B9H4E4) Dihydrofolate reductase-thymidylate synthase OS=Populus
           trichocarpa GN=DHFR-TS-3a PE=3 SV=1
          Length = 252

 Score =  285 bits (728), Expect = 2e-74,   Method: Compositional matrix adjust.
 Identities = 140/208 (67%), Positives = 162/208 (77%), Gaps = 3/208 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R+YQVVVAAT+DMGIGKDGKLPWRL  DLKFFKEIT ATSDPGK+NAI+MGRKTWESIP+
Sbjct: 18  RSYQVVVAATRDMGIGKDGKLPWRLPCDLKFFKEITLATSDPGKQNAILMGRKTWESIPI 77

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           KYRPLPGRLNVVLTRS  F+I   ENV+ CGSI          PYC SI+KVFVIGGGQI
Sbjct: 78  KYRPLPGRLNVVLTRS--FEIEDEENVITCGSISSALELLAEAPYCFSIDKVFVIGGGQI 135

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
            RE LN PGC+AIH TEI  S+ECDTF+P +D +K+Q WYSS P VEN IRYSF TYV V
Sbjct: 136 LRETLNGPGCDAIHVTEIETSVECDTFIPSIDFSKFQPWYSSPPLVENGIRYSFVTYVHV 195

Query: 244 QSSAAESLSQNT-DPLFDNNSDSLKFEV 270
           ++S  E+++  T     D  S+S +FE+
Sbjct: 196 RNSENETIAGKTGGKCNDGKSNSNRFEI 223


>R0FWL1_9BRAS (tr|R0FWL1) Uncharacterized protein OS=Capsella rubella
           GN=CARUB_v10023109mg PE=4 SV=1
          Length = 483

 Score =  283 bits (724), Expect = 6e-74,   Method: Compositional matrix adjust.
 Identities = 139/266 (52%), Positives = 179/266 (67%), Gaps = 12/266 (4%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           +R+YQVV+AAT+DMG+G D KLPW L  + +FF+ +TT TSDP K+NA +MGRKTW+S P
Sbjct: 19  RRSYQVVIAATRDMGLGMDMKLPWDLPMEYEFFQGVTTKTSDPKKRNATIMGRKTWDSTP 78

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           L++RPL GRLNVVLT S   DIG  +NV++C ++          PY LSIE VFVIGGG+
Sbjct: 79  LEFRPLLGRLNVVLTSSSCLDIGADDNVLVCSTMESALELLATAPYSLSIETVFVIGGGE 138

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + R  +NAP CEAIH TEI  S+ CD F P VD++ Y  WYSSFP++EN  RYSF TYVR
Sbjct: 139 LLRNYMNAPDCEAIHLTEIDISVPCDAFAPRVDTSLYHPWYSSFPRMENGTRYSFNTYVR 198

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
            ++    S  + +    D       F+ Q + FLP+M+ +RHEE+ YL L+Q IIS    
Sbjct: 199 RKNHIFGSGEKKSVVGSD-------FK-QYYSFLPKMVFERHEEFGYLNLVQNIIS---- 246

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR++FP
Sbjct: 247 TGDMNDNTTLSKFGCQMRFNLRKTFP 272


>Q9SIK4_ARATH (tr|Q9SIK4) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Arabidopsis thaliana GN=AT2G21550 PE=3 SV=1
          Length = 492

 Score =  282 bits (721), Expect = 1e-73,   Method: Compositional matrix adjust.
 Identities = 136/266 (51%), Positives = 181/266 (68%), Gaps = 13/266 (4%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           +R+YQVV+AAT+DMG+G D KLPW L ++ +FF+++TT TSDP K+NA +MGRK+WES P
Sbjct: 21  RRSYQVVIAATRDMGLGMDMKLPWDLPSEYQFFQDVTTRTSDPTKRNATIMGRKSWESTP 80

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           L+ RPLPGRLN+VLT+S   +I   ENV++  S+          PY LSIEKVFVIGGG+
Sbjct: 81  LEIRPLPGRLNIVLTKSSCHNIAIDENVLVSSSMESALELLATEPYSLSIEKVFVIGGGE 140

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + R  +NA  C+AIH TEI  S+ CD F P VD++ Y+ WYSSFP VEN IRYSF TYVR
Sbjct: 141 LLRNYMNASICDAIHLTEIDISVPCDAFAPRVDTSLYRPWYSSFPVVENGIRYSFNTYVR 200

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
            + +   S  + +           + +++ + FLP+M+ +RHEE+ YL L+Q IIS    
Sbjct: 201 RKDAIVGSGEKKS---------VAESDLKEYSFLPKMVFERHEEFGYLNLVQNIISS--- 248

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    LSKFGCQMRFNLR++FP
Sbjct: 249 -GDMNDNSTLSKFGCQMRFNLRKTFP 273


>D7LBE8_ARALL (tr|D7LBE8) Predicted protein OS=Arabidopsis lyrata subsp. lyrata
           GN=ARALYDRAFT_667353 PE=4 SV=1
          Length = 490

 Score =  274 bits (700), Expect = 4e-71,   Method: Compositional matrix adjust.
 Identities = 137/266 (51%), Positives = 180/266 (67%), Gaps = 13/266 (4%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           +R+YQVV+AAT+DMG+G D KLPW L TD +FF ++TT T+DP ++NA +MGRK+WES P
Sbjct: 19  RRSYQVVIAATRDMGLGMDMKLPWDLPTDSQFFHDVTTRTTDPTRRNATIMGRKSWESTP 78

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           L+ RPLPGRLN+VLT+S   +I   ENV++C S+          PY LSIEKVFVIGGG+
Sbjct: 79  LEIRPLPGRLNIVLTKSSCHNIAIDENVLVCDSMESALELLATEPYSLSIEKVFVIGGGE 138

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + R  +NAP C+AIH TEI  S+ CD F P VD++ Y  WYSSFP VEN IRYSF TYVR
Sbjct: 139 LLRNYMNAPSCDAIHLTEIDISVPCDAFAPRVDTSLYHPWYSSFPIVENGIRYSFNTYVR 198

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
            + +   S  + +         +   + + + FLP+M+ +RH+E+ YL LIQ IIS    
Sbjct: 199 RKDAVVGSGEKKS---------AAGSDFKEYSFLPKMVFERHDEFGYLNLIQNIISS--- 246

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    L+KFGCQMRFNLR++FP
Sbjct: 247 -GDMNDNNTLTKFGCQMRFNLRKTFP 271


>D8SA97_SELML (tr|D8SA97) Putative uncharacterized protein OS=Selaginella
           moellendorffii GN=SELMODRAFT_233517 PE=3 SV=1
          Length = 509

 Score =  260 bits (665), Expect = 4e-67,   Method: Compositional matrix adjust.
 Identities = 128/265 (48%), Positives = 173/265 (65%), Gaps = 20/265 (7%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R +QVVVAAT D+GIGK+GKLPW + +D+ FFK IT+  +D  KKNA+VMGR+TWESIP 
Sbjct: 24  RAFQVVVAATTDLGIGKEGKLPWSVPSDMAFFKRITSEAADARKKNAVVMGRRTWESIPA 83

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           K+RPLPGR+NVVL+R+G  ++G  +  ++C S+          P+  S+E VFVIGGG++
Sbjct: 84  KFRPLPGRVNVVLSRAG-LELG--DKAIVCSSLDSALGILAAPPFDSSVEAVFVIGGGEV 140

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
           FRE + +P C AIH TEI    ECDTFMP +D T ++LWY+S P   N++R+SF TYVR 
Sbjct: 141 FREAMVSPLCTAIHLTEIQTFFECDTFMPALDLTCFRLWYASSPATVNNVRHSFHTYVRN 200

Query: 244 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 303
           ++    +++          + SL         +PE + +RHEEY YL LI++II      
Sbjct: 201 KALDVRNVA---------GTSSLP--------IPEFVRERHEEYQYLNLIKDIIETGNTK 243

Query: 304 XXXXXXXXLSKFGCQMRFNLRRSFP 328
                   +SKFGCQMRFNLR SFP
Sbjct: 244 SDRTGTGTISKFGCQMRFNLRNSFP 268


>D8QVP4_SELML (tr|D8QVP4) Putative uncharacterized protein OS=Selaginella
           moellendorffii GN=SELMODRAFT_404548 PE=3 SV=1
          Length = 502

 Score =  259 bits (662), Expect = 1e-66,   Method: Compositional matrix adjust.
 Identities = 128/265 (48%), Positives = 173/265 (65%), Gaps = 20/265 (7%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R +QVVVAAT+D+GIGK+GKLPW + +D+ FFK IT+  +D  KKNA+VMGR+TWESIP 
Sbjct: 17  RAFQVVVAATRDLGIGKEGKLPWSVPSDMAFFKRITSEAADARKKNAVVMGRRTWESIPA 76

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           K+RPLPGR+NVVL+R+G  ++G  +  ++C S+          P+  S+E VFVIGGG++
Sbjct: 77  KFRPLPGRVNVVLSRAG-LELG--DKAIVCSSLDSALGILAAPPFDSSVEAVFVIGGGEV 133

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
           FRE + +P C AIH TEI    ECDTFMP +D T ++LWY+S P   N++R+SF TYVR 
Sbjct: 134 FREAMVSPLCTAIHLTEIQTFFECDTFMPALDLTCFRLWYASSPATVNNVRHSFHTYVRN 193

Query: 244 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 303
           ++    +++            SL         +PE + +RHEEY YL LI++II      
Sbjct: 194 KALDVRNVAGTC---------SLP--------IPEFVRERHEEYQYLNLIKDIIETGNTR 236

Query: 304 XXXXXXXXLSKFGCQMRFNLRRSFP 328
                   +SKFGCQMRFNLR SFP
Sbjct: 237 SDRTGTGTISKFGCQMRFNLRNSFP 261


>M4C8Q3_BRARP (tr|M4C8Q3) Uncharacterized protein OS=Brassica rapa subsp.
           pekinensis GN=Bra000581 PE=4 SV=1
          Length = 452

 Score =  257 bits (656), Expect = 5e-66,   Method: Compositional matrix adjust.
 Identities = 129/260 (49%), Positives = 167/260 (64%), Gaps = 20/260 (7%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           +R+YQVV+AAT+DMGIG D KLPW L  + +FF+++T+ TSDP K+NA +MGRK+WE+ P
Sbjct: 8   RRSYQVVIAATRDMGIGIDMKLPWDLPNEFQFFQDVTSRTSDPRKRNATIMGRKSWEATP 67

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGT-AENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           L++RPLP RLNVVLTRS    I T  +NV++CGS+          PY  SIEKVF IGGG
Sbjct: 68  LEFRPLPDRLNVVLTRSNCHSIPTDDDNVMVCGSMESALELLAKPPYSFSIEKVFFIGGG 127

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           ++ R  +NAP C+AIH TE+  ++ CDTF P VD+  Y  WYSS P VEN IRY F TYV
Sbjct: 128 ELLRHYMNAPSCDAIHLTEVDITVPCDTFAPRVDTCLYHPWYSSLPVVENGIRYCFNTYV 187

Query: 242 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXX 301
           R +           D +F +       E + + FLP+M+ +RHEE+ YL L+Q IIS   
Sbjct: 188 RRK-----------DLIFGSG-----VEAEQYSFLPKMVFERHEEFGYLNLVQNIISN-- 229

Query: 302 XXXXXXXXXXLSKFGCQMRF 321
                     LSKFGCQ  F
Sbjct: 230 -GDMNDNNTLLSKFGCQKVF 248


>A9RXS0_PHYPA (tr|A9RXS0) Predicted protein OS=Physcomitrella patens subsp.
           patens GN=PHYPADRAFT_120817 PE=3 SV=1
          Length = 520

 Score =  233 bits (593), Expect = 1e-58,   Method: Compositional matrix adjust.
 Identities = 127/269 (47%), Positives = 165/269 (61%), Gaps = 20/269 (7%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R +Q+VVAAT++ GIGK G LPW+L TD+KFFK +T+ T+   KKNA++MGR TWESIP 
Sbjct: 27  RGFQIVVAATRERGIGKQGHLPWKLPTDMKFFKTVTSVTTSSSKKNAVIMGRHTWESIPE 86

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           K+RPLPGRLNV+LTRSG     T   VV+  S+           Y   +E VFVIGGGQ+
Sbjct: 87  KFRPLPGRLNVILTRSGIKS--TPAGVVVSESLQSALALIATPSYSSHVESVFVIGGGQL 144

Query: 184 F----REVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
                 E + +P CE IH TE+   +ECDT+MP VD+  +++W +S P VEN +R SF T
Sbjct: 145 VSTVCSEAMASPLCEVIHLTEVEGDVECDTYMPAVDTDIFRIWSASIPIVENGLRISFLT 204

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           YVR   S   S+ Q      DN   ++         LP+ +L+ H+EY YL LI +II  
Sbjct: 205 YVR--GSLTSSIKQT-----DNGETTV-------GLLPKYLLEAHDEYQYLNLIDDIIKT 250

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       +SKFGCQMRFNLR+SFP
Sbjct: 251 GAVKGDRTGTGTISKFGCQMRFNLRKSFP 279


>Q01FK1_OSTTA (tr|Q01FK1) Bifunctional dihydrofolate reductase-thymidylate
           synthase 2 / DHFR-TS (ISS) OS=Ostreococcus tauri
           GN=Ot01g05780 PE=3 SV=1
          Length = 751

 Score =  222 bits (566), Expect = 1e-55,   Method: Compositional matrix adjust.
 Identities = 119/273 (43%), Positives = 151/273 (55%), Gaps = 26/273 (9%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R +QVVVAAT D GIGKD  LPW+L  D+  FK++T+ T D    NA+VMGRKTWESIP 
Sbjct: 256 RAFQVVVAATVDGGIGKDNGLPWKLTKDMGHFKKLTSETRDANAVNAVVMGRKTWESIPA 315

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLS--------IEKV 175
           K+RPLPGRLNVVL+RSG       EN     ++             LS        +EK 
Sbjct: 316 KFRPLPGRLNVVLSRSGVLAEANDENNNGAETLPEGVLVRKTIDDALSAISSSEKRVEKT 375

Query: 176 FVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRY 235
           FVIGG QI+ E L +  CEA+H TE+    ECD F+P +D+ K++L+  S P  EN  RY
Sbjct: 376 FVIGGAQIYEEALKSERCEAVHLTEVEGDFECDVFIPKIDADKFKLYGQSKPITENGARY 435

Query: 236 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 295
            F TYV                    +S+S KF     + LP     +HEE+ YL +I+E
Sbjct: 436 QFLTYV------------------TKDSESGKFRPIAGELLPAGCDVKHEEHQYLDMIRE 477

Query: 296 IISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           II +            +S FG QMRF+LRRSFP
Sbjct: 478 IIDQGAVKGDRTGTGTISTFGNQMRFDLRRSFP 510


>A4RXM1_OSTLU (tr|A4RXM1) Predicted protein OS=Ostreococcus lucimarinus (strain
           CCE9901) GN=OSTLU_49676 PE=3 SV=1
          Length = 499

 Score =  221 bits (562), Expect = 4e-55,   Method: Compositional matrix adjust.
 Identities = 116/271 (42%), Positives = 154/271 (56%), Gaps = 26/271 (9%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           +QVVVAAT++ GIG++  LPWRL  D+ +FK+IT+ T D    NA+VMGRKTWESIP K+
Sbjct: 6   FQVVVAATREGGIGRENALPWRLAGDMGYFKKITSETRDGDAMNAVVMGRKTWESIPGKF 65

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLS--------IEKVFV 177
           RPLPGRLN+VL+RSG       EN     ++             LS        IEK FV
Sbjct: 66  RPLPGRLNIVLSRSGGLAEANDENNNGAETLPEGVLVRKSIDDALSAISSSEKRIEKTFV 125

Query: 178 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSF 237
           IGG QI+ E L +  CEA+H TE+    ECD F+P +D+TK++L+  S P +E   R+ F
Sbjct: 126 IGGAQIYEEALQSEKCEAVHLTEVEGEFECDAFIPKIDATKFKLYGQSKPMIEKGTRFQF 185

Query: 238 ATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEII 297
            TYV                    +++S KF  +  + LP     +HEEY YL +I+EII
Sbjct: 186 LTYVTA------------------DAESGKFRPKADEVLPAGCSIKHEEYQYLEMIREII 227

Query: 298 SEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
            +            +S FG QMRF+LRRSFP
Sbjct: 228 DQGAVKGDRTGTGTISTFGNQMRFDLRRSFP 258


>B9HRK6_POPTR (tr|B9HRK6) Dihydrofolate reductase-thymidylate synthase OS=Populus
           trichocarpa GN=DHFR-TS-2 PE=3 SV=1
          Length = 414

 Score =  216 bits (550), Expect = 1e-53,   Method: Compositional matrix adjust.
 Identities = 101/162 (62%), Positives = 123/162 (75%)

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSF 226
           PY LSIEKVFVIGGGQI RE LNAPGC+AIH TEI    +CDTF+P +D++ +Q W SSF
Sbjct: 12  PYFLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVFQPWCSSF 71

Query: 227 PKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEE 286
           PK+ENDIRY F TYVRV+SSA ES SQ      D NS++ KFEV+ F FLP+M+ +RHEE
Sbjct: 72  PKMENDIRYCFTTYVRVRSSAIESHSQKNGVSSDGNSENSKFEVKKFSFLPKMVFERHEE 131

Query: 287 YMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           Y+YLRL+Q+II++            LSKFGCQMRFNLR++FP
Sbjct: 132 YLYLRLVQDIITDGNLKDGRAGTGTLSKFGCQMRFNLRKTFP 173


>I0YVC8_9CHLO (tr|I0YVC8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Coccomyxa subellipsoidea C-169
           GN=COCSUDRAFT_37014 PE=3 SV=1
          Length = 479

 Score =  213 bits (542), Expect = 7e-53,   Method: Compositional matrix adjust.
 Identities = 112/266 (42%), Positives = 149/266 (56%), Gaps = 34/266 (12%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           Q T+Q+VVAAT+ +GIGK G +PW+L  D+ +FKE+TT T+DP  +NA+VMGRKTWESIP
Sbjct: 7   QLTFQIVVAATRKLGIGKGGTMPWKLPGDMAYFKELTTRTADPNNQNAVVMGRKTWESIP 66

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K+RPLPGR+NVVL+R               GS+           +   IE VFVIGGG+
Sbjct: 67  PKFRPLPGRVNVVLSRGS------------VGSLEAAMALLGETSFKERIETVFVIGGGK 114

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           ++ E L +P C A+HFT I A IECDTF P +   K++LW  S P+   D+RYSF  YV 
Sbjct: 115 VYEEALPSPLCSAVHFTAIEADIECDTFFPEMSLDKWRLWSESAPRRNGDMRYSFQCYVP 174

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
             +S++ S                             +  +HEE  YL ++ +II     
Sbjct: 175 ASASSSSSPPALP----------------------PAVAAQHEELQYLNMVDDIIRNGVF 212

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                     +KFGCQMRFNLR +FP
Sbjct: 213 RGDRTGTGTFTKFGCQMRFNLRHTFP 238


>E1ZCI9_CHLVA (tr|E1ZCI9) Putative uncharacterized protein OS=Chlorella
           variabilis GN=CHLNCDRAFT_30873 PE=3 SV=1
          Length = 508

 Score =  212 bits (539), Expect = 2e-52,   Method: Compositional matrix adjust.
 Identities = 112/286 (39%), Positives = 151/286 (52%), Gaps = 45/286 (15%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           +RT Q+VVAATK  GIGK G LPW L  D+K+F+E+T+ T+DP K+N ++MGRKTWESIP
Sbjct: 7   RRTIQIVVAATKQWGIGKGGSLPWSLPGDMKYFRELTSRTADPAKQNVVIMGRKTWESIP 66

Query: 123 LKYRPLPGRLNVVLTR----------------SGSFDIGTAENVVICGSIXXXXXXXXXX 166
            K+RPL GR+NVVLTR                +   +   AE V I  S+          
Sbjct: 67  AKFRPLAGRINVVLTRGAVAGDENASAPGNATAALAEASKAEGVHISSSLDSALEMLSGP 126

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFT----EIHASIECDTFMPPVDSTKYQLW 222
            +   +E VFVIGGGQ+++E + +P   AIH T    E   +  CDTFMPPVD ++++LW
Sbjct: 127 EFDSRVESVFVIGGGQVYKECMESPLLSAIHLTLVEGEAAEAANCDTFMPPVDESRFRLW 186

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
            +S P+     RYSF  Y R                            +    LP  +  
Sbjct: 187 SASAPRSVGGTRYSFLCYTRAGQ-------------------------EGLPALPPTVAS 221

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           RHEE+ YL +I+++++              SKFG  MRFNLR SFP
Sbjct: 222 RHEEHQYLEMIEDVMANGVFRGDRTGTGTYSKFGATMRFNLRHSFP 267


>C1MMA6_MICPC (tr|C1MMA6) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Micromonas pusilla (strain CCMP1545)
           GN=DHFR-TS PE=3 SV=1
          Length = 524

 Score =  206 bits (525), Expect = 8e-51,   Method: Compositional matrix adjust.
 Identities = 116/292 (39%), Positives = 161/292 (55%), Gaps = 45/292 (15%)

Query: 64  RTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R +QVVVAATK DMGIG DG LPWRL  D+ +FK +T   ++PGK+NA++MGRKTWESIP
Sbjct: 10  RPFQVVVAATKGDMGIGLDGALPWRLPKDMAYFKSVTATVAEPGKRNAVIMGRKTWESIP 69

Query: 123 LKYRPLPGRLNVVLTRSGSF-----------DIGTAEN-----VVICGSIXXXXXXXXXX 166
            K+RPLPGRLNVVL++SG+              GT  N     V++  S+          
Sbjct: 70  AKFRPLPGRLNVVLSKSGALVESTGSENAAPANGTPSNVLPPSVLLQPSLEAALATLGAG 129

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHA------SIECDTFMPPVDSTKYQ 220
            +  ++EK+FV+GG Q++ E + +P C+A+H TE+        + +CDT MPPVD  K++
Sbjct: 130 EHAENVEKIFVVGGAQVYAEAMASPACQAVHITEVTPPKDTPDAFKCDTHMPPVDMEKFK 189

Query: 221 LWYSSFPKVEND-IRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           L+ S+ P  E +  +  F +YV   ++                    KF +     LP  
Sbjct: 190 LYASAPPVNEKEGAKIQFLSYVAKDAATG------------------KFRIPGSVSLPPG 231

Query: 280 ILQ---RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
            +    RHEE  YL LI++II              +SKFG  MRF+LRRSFP
Sbjct: 232 AVANGVRHEELQYLDLIRDIIESGNVKGDRTGTGTISKFGTSMRFDLRRSFP 283


>C1E6F7_MICSR (tr|C1E6F7) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Micromonas sp. (strain RCC299 / NOUM17)
           GN=DHFR-TS PE=3 SV=1
          Length = 523

 Score =  197 bits (501), Expect = 4e-48,   Method: Compositional matrix adjust.
 Identities = 117/292 (40%), Positives = 155/292 (53%), Gaps = 45/292 (15%)

Query: 64  RTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R +QVVVAATK +MGIG  G LPW L  D+ +FK +T+  ++PG KNA+VMGRKTWESIP
Sbjct: 9   RPFQVVVAATKGEMGIGYQGGLPWNLPKDMAYFKAVTSQVNEPGTKNAVVMGRKTWESIP 68

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAEN----------------VVICGSIXXXXXXXXXX 166
            K+RPLPGR+NVVL+R  +     +EN                V +  S+          
Sbjct: 69  AKFRPLPGRVNVVLSRGHTLVEAGSENSAPVNGGGKPEVLPEGVFLRPSLEAALELLSAP 128

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIE------CDTFMPPVDSTKYQ 220
            +   +EKVFVIGG Q++ E + +P C+A+H TE+    +      CD F+P +D  K++
Sbjct: 129 EHEAGVEKVFVIGGAQVYAEAMASPHCQALHLTEVTPPADEPEKYKCDAFLPQIDPAKFK 188

Query: 221 LWYSSFPKVEND-IRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEM 279
           L+ S+ P  E D     F TY  V            DP       + KF       LP  
Sbjct: 189 LYASAKPLREKDGATIQFLTYFGV------------DP------GTGKFRSPGSKVLPAG 230

Query: 280 ILQ---RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
            +    RHEE  YL LI+EI+ E            +SKFGCQMRF+LRRSFP
Sbjct: 231 AVAKGVRHEEMQYLDLIKEIMEEGNVKGDRTGTGTISKFGCQMRFDLRRSFP 282


>K8ECA8_9CHLO (tr|K8ECA8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Bathycoccus prasinos GN=Bathy03g03500 PE=3
           SV=1
          Length = 528

 Score =  191 bits (485), Expect = 3e-46,   Method: Compositional matrix adjust.
 Identities = 117/301 (38%), Positives = 156/301 (51%), Gaps = 48/301 (15%)

Query: 58  PLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKT 117
           P  +  + +QVVVA+ +  GIGK+  LPW+L  ++K FK +T   S P  +NA++MGRKT
Sbjct: 5   PTKDDLKKFQVVVASDELGGIGKNQTLPWKLSKEMKHFKSLTADVSKPMTQNAVIMGRKT 64

Query: 118 WESIPLKYRPLPGRLNVVLTRSGS-FDIGTAEN------------------VVICGSIXX 158
           WESIP K+RPLPGRLNVVL+ SG  ++    EN                  V+   SI  
Sbjct: 65  WESIPEKFRPLPGRLNVVLSASGRVYEKSNKENGGPGEDDAEGGAKCLPEGVLARASIEE 124

Query: 159 XXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEI--------HASIECDTF 210
                    Y   IEKVFVIGG +++ E L +  CEA+H TE+             CD F
Sbjct: 125 ALETLSTGEYKDIIEKVFVIGGAKVYEEALKSEQCEAVHLTEVKPPAGKDPKEHFACDAF 184

Query: 211 MP-PVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFE 269
           +P P+DS K++L+ SS    + +  Y+  TYV                    N  + KF 
Sbjct: 185 IPLPLDSEKFRLYSSSKLVKDGECSYTTLTYVA------------------QNGPAGKFR 226

Query: 270 VQNFDFLPEMIL--QRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSF 327
           V+    LP  IL  Q+HEE  YL LI+EII E            +SKFGC MR++LRRSF
Sbjct: 227 VEAEKILPPKILKEQKHEEMQYLELIREIIDEGNVKGDRTGTGTISKFGCSMRYDLRRSF 286

Query: 328 P 328
           P
Sbjct: 287 P 287


>A8JD96_CHLRE (tr|A8JD96) Predicted protein OS=Chlamydomonas reinhardtii
           GN=CHLREDRAFT_139742 PE=3 SV=1
          Length = 478

 Score =  191 bits (485), Expect = 3e-46,   Method: Compositional matrix adjust.
 Identities = 102/267 (38%), Positives = 144/267 (53%), Gaps = 35/267 (13%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLP-WRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           ++ +Q+V+AAT  +GIGK+GKLP W+L  D+ +FKE+T+ T D    NA++MGRKTWESI
Sbjct: 5   RKGFQLVIAATPSLGIGKNGKLPDWQLPGDMAYFKELTSRTRDGAHTNAVIMGRKTWESI 64

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P K+RPL GRLN+VL+RS + D    E+ +                    +E VF+IGGG
Sbjct: 65  PAKFRPLKGRLNIVLSRSFADDADLLESALSLLEHKELKG---------GVEGVFIIGGG 115

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           Q++ E L  P C A+H T++    ECDTF+P +D   + +W SS P  EN+ RYSF  Y 
Sbjct: 116 QVYAEALAHPNCTAVHLTQVEKEYECDTFLPALDPAVWGVWSSSEPVTENNTRYSFVCYT 175

Query: 242 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXX 301
           R  +  A                           LP  +  RH+E  YL L++E+I+   
Sbjct: 176 RRGTEQAPE-------------------------LPPCMASRHDEQQYLELVRELITSGV 210

Query: 302 XXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      S+FG   R+NLR +FP
Sbjct: 211 FRPDRTGTGTYSRFGRTSRYNLRHTFP 237


>D8UB22_VOLCA (tr|D8UB22) Putative uncharacterized protein OS=Volvox carteri
           GN=VOLCADRAFT_66296 PE=3 SV=1
          Length = 483

 Score =  182 bits (463), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 95/267 (35%), Positives = 141/267 (52%), Gaps = 29/267 (10%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLP-WRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
            + +Q+VVAAT  +GIGK+G LP W+L  D+ +F+E+T+ T +P  +N  +MGRKTWESI
Sbjct: 4   HKGFQLVVAATPSLGIGKNGTLPGWKLPGDMAYFRELTSRTREPSCQNVAIMGRKTWESI 63

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P K+RPL GR+N++  R+G+       +V+ C S+               ++ VFVIGG 
Sbjct: 64  PNKFRPLKGRINIIARRNGA---QFGPDVLGCSSLGAALELLEDEKLKRDVDFVFVIGGA 120

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           Q++ E L  P C A+H T++    +CD  +PP+D + + +W +S P  END RYSF  Y 
Sbjct: 121 QVYAEALRHPSCTAVHLTKVEKEFDCDAHLPPLDPSVFGVWSASEPFQENDTRYSFVCYT 180

Query: 242 RVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXX 301
           R   S                             LP  +  RH+E  YL L++E+I+   
Sbjct: 181 RRGLSPPPE-------------------------LPPGMASRHDEIQYLELVRELITSGT 215

Query: 302 XXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                      S+FG   R+NLR +FP
Sbjct: 216 FRPDRTGTGTYSRFGRTARYNLRHTFP 242


>L1JGV3_GUITH (tr|L1JGV3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Guillardia theta CCMP2712
           GN=GUITHDRAFT_69716 PE=3 SV=1
          Length = 478

 Score =  156 bits (395), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 96/270 (35%), Positives = 137/270 (50%), Gaps = 44/270 (16%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATS--DPGKKNAIVMGRKTWESIPLKY 125
           ++VA TK+ GIG+DGKLPW L  D+ +FK++TT  S   P   NA++MGRKTWESIP  +
Sbjct: 1   MIVACTKNGGIGRDGKLPWNLKEDMAWFKKVTTEASADKPEGCNAVIMGRKTWESIPPSF 60

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPL GR+N+VL+RS    +   + VV+  S+               I + FVIGGG+++R
Sbjct: 61  RPLSGRVNIVLSRSPD-SMSVPDGVVLSKSLADAMQVVDSRD---DISQCFVIGGGELYR 116

Query: 186 EVLNAPG-CEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPK------VENDIRYSFA 238
           E +N+   C+ I  T +H   ECDTF+P              PK       +  I+Y F 
Sbjct: 117 EAMNSDRLCKVIFRTLVHGEFECDTFIP-----------CEIPKGFIRDTEDKGIQYEFQ 165

Query: 239 TYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIIS 298
            +VR  ++ + S S+    + +  +                    HEEY YL LI++I+ 
Sbjct: 166 IFVRPATAGSNSHSEMNSHVSNGVA--------------------HEEYQYLNLIRDILQ 205

Query: 299 EXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                        + KFG  MRFNLR SFP
Sbjct: 206 TGIRKGDRTGTGTIGKFGASMRFNLRESFP 235


>D8LWN8_BLAHO (tr|D8LWN8) Thymidylate synthase OS=Blastocystis hominis
           GN=GSBLH_T00000592001 PE=3 SV=1
          Length = 495

 Score =  149 bits (377), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 88/262 (33%), Positives = 127/262 (48%), Gaps = 33/262 (12%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + +V A T   GIG +G LPWR+  D+KFF ++TT T+D  K+NA+++G+ T+ S P K+
Sbjct: 6   FSIVAAMTTKRGIGLNGGLPWRIKQDMKFFVDLTTTTTDSEKQNAVIIGKNTYFSFPEKF 65

Query: 126 RPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           RPL  R+N +++            ++V IC S+               IE +FVIGGGQI
Sbjct: 66  RPLKNRINFIISHDKELREKHNIPDSVYICSSVDEALILMQEEELKRKIENIFVIGGGQI 125

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
           +++ +N P CE ++ TE+ A I CDTF P +    Y+    S    EN+ ++ FA Y R+
Sbjct: 126 YKKAINLPECEKLYLTEVDADISCDTFFPEI-PLAYKKTKESETFEENNFKFRFAEYTRL 184

Query: 244 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLP--EMILQRHEEYMYLRLIQEIISEXX 301
             +                            FLP     LQ HEE  YL LI+ I+    
Sbjct: 185 PMT----------------------------FLPPYRTSLQEHEELQYLNLIRYILDHGA 216

Query: 302 XXXXXXXXXXLSKFGCQMRFNL 323
                      S FG QMRF L
Sbjct: 217 LRTDRTNTGTRSVFGTQMRFLL 238


>K2CJT4_9BACT (tr|K2CJT4) Bifunctional dihydrofolate reductase-thymidylate
           synthase 2 / DHFR-TS (ISS) OS=uncultured bacterium
           GN=ACD_28C00163G0011 PE=3 SV=1
          Length = 204

 Score =  147 bits (372), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 77/189 (40%), Positives = 109/189 (57%), Gaps = 7/189 (3%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKK-NAIVMGRKTWESI 121
           ++ + +VVA  +  GIGKDG LPW L +DLK F  IT  TS      NA++MGRKTW S+
Sbjct: 20  RQMFSIVVAMDEARGIGKDGVLPWHLPSDLKHFAHITKTTSSVHNAVNAVIMGRKTWGSL 79

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P ++RPLPGRLN+VL+R  + D+     V++  S+              + E++FVIGGG
Sbjct: 80  PERFRPLPGRLNIVLSRQQNHDL--PRGVLLADSLDEAILKAKKA----NAEQLFVIGGG 133

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           ++F E L+ P CE ++ T I    ECDTF+P  D   ++    S    EN I + F TY 
Sbjct: 134 RVFEEALHDPHCEKLYITRIKGDFECDTFLPRWDENTFEKIEESGLHQENGIDFQFQTYR 193

Query: 242 RVQSSAAES 250
           R +S +  S
Sbjct: 194 RKESHSLTS 202


>C3Z0P2_BRAFL (tr|C3Z0P2) Putative uncharacterized protein OS=Branchiostoma
           floridae GN=BRAFLDRAFT_268308 PE=3 SV=1
          Length = 185

 Score =  147 bits (371), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 73/183 (39%), Positives = 110/183 (60%), Gaps = 5/183 (2%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           +   +VVAA  +MGIG DGK+PW L  D+KFF  +T+ T + GK+NA+VMGRKTW SIP 
Sbjct: 4   KKLSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTSGTEEAGKQNAVVMGRKTWFSIPD 63

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           ++RPLP RLNVVL+R+ +     A +  + GS+              +I+KVF+IGG  +
Sbjct: 64  RFRPLPKRLNVVLSRNLTTPPEGAHH--LAGSLEEAVKMLTETTVADTIDKVFIIGGNSV 121

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP---KVENDIRYSFATY 240
           +++ L+ P C  ++ T ++  + CDTF P +D T   +   + P   + EN I Y +  Y
Sbjct: 122 YKDALSHPCCHRVYLTRVYKDVHCDTFFPNMDDTFKLVSDPTIPSEMQEENGIEYKYEVY 181

Query: 241 VRV 243
            +V
Sbjct: 182 EKV 184


>R1BUZ9_EMIHU (tr|R1BUZ9) Uncharacterized protein OS=Emiliania huxleyi CCMP1516
           GN=EMIHUDRAFT_451981 PE=4 SV=1
          Length = 495

 Score =  147 bits (371), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 97/311 (31%), Positives = 140/311 (45%), Gaps = 72/311 (23%)

Query: 58  PLPNLQRTYQVVVAATKD-MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRK 116
           P     R + VVVAA K   GIG   +LPWRL  D+++FK++T +T DP K+NA++MGRK
Sbjct: 6   PAKEGGRRFSVVVAACKQSRGIGVSNQLPWRLRGDMQYFKQLTRSTRDPTKQNAVIMGRK 65

Query: 117 TWESIPLKYRPLPGRLNVVLTRSGSFD--IGTAENVVICGSIXXXXXXXXXXPYCLSIEK 174
           TWESIP K RPL  RLNVV++ + +     G  + V++  S+           Y  S+E 
Sbjct: 66  TWESIPEKMRPLGDRLNVVISANPAARELYGMGDKVLLATSLGDALQQLCEGDYAASVES 125

Query: 175 VFVIGGGQIFREVLNAPG-CEAIHFTEI--HASIE------------------------- 206
           VFVIGG  ++ E ++ P  CE +++TE+  HA +                          
Sbjct: 126 VFVIGGSSVYAEAVDLPQLCERVYYTEVSKHAPLRDANGAAPPAAAAAVGPATEAAAAGC 185

Query: 207 ---------CDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDP 257
                    CDT  PP+ +  ++   +S P+ EN + Y F  +   +S  A +       
Sbjct: 186 VGGSDDPFGCDTHFPPLPADTWRQASASAPRDENGLSYRFLAFESRESPPAAA------- 238

Query: 258 LFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGC 317
                                     HEE  YL L++E+I                KFG 
Sbjct: 239 -------------------------PHEELQYLDLVREVIESGVSRPDRTGIGTRGKFGA 273

Query: 318 QMRFNLRRSFP 328
           QMRF+LR  FP
Sbjct: 274 QMRFSLRDRFP 284


>H8ZWN9_9EUKA (tr|H8ZWN9) Dihydrofolate reductase-thymidylate synthase (Fragment)
           OS=Collodictyon triciliatum PE=2 SV=1
          Length = 385

 Score =  145 bits (367), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 85/234 (36%), Positives = 120/234 (51%), Gaps = 28/234 (11%)

Query: 95  FKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICG 154
           F+  T+A +D  K+NA++MGRKTW+SIP   RPL  RLNV+++ S   +     N+ +  
Sbjct: 1   FRTKTSALNDSSKRNALIMGRKTWDSIPQNRRPLANRLNVIVS-STFVNTEKNPNIEVVS 59

Query: 155 SIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPV 214
           +            Y   IE VFVIGGGQI++E + +P C++I  T++ A IECDTF P +
Sbjct: 60  TFEDAHELVSLGKYKREIENVFVIGGGQIYKEAIESPYCKSISLTKVFADIECDTFFPKI 119

Query: 215 DSTKYQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFD 274
           +   ++   SS  K EN IRY      R+ +    SL  NT                   
Sbjct: 120 NPDIFKTSTSSDIKEENSIRYQITQLERI-TQPQTSLVINT------------------- 159

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                  QRHEE+ YL L++ I++E            +S FG QMRF+LR SFP
Sbjct: 160 -------QRHEEHQYLDLVRRILTEGVFKSDRTGVGTVSLFGAQMRFSLRESFP 206


>G4YSZ0_PHYSP (tr|G4YSZ0) Putative uncharacterized protein OS=Phytophthora sojae
           (strain P6497) GN=PHYSODRAFT_555231 PE=3 SV=1
          Length = 491

 Score =  145 bits (365), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 96/275 (34%), Positives = 138/275 (50%), Gaps = 37/275 (13%)

Query: 63  QRTYQVVVAATKDMG-IGKDGKLPWRLFTDLKFFKEITTA--TSDPGKKNAIVMGRKTWE 119
           +R+ +VVVAA +  G IG   ++PWRL +D+K FK +TTA  +S    ++A++MGRKTWE
Sbjct: 3   ERSVRVVVAALEATGGIGLRQQIPWRLPSDMKHFKALTTAPSSSSSSAQHAVIMGRKTWE 62

Query: 120 SIPLKYRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFV 177
           S+P K RP+P R NVVLTR  S+    G  E+V +  S                +++VFV
Sbjct: 63  SLPAKVRPMPQRYNVVLTRDASYRQSQGVPESVGVAASFREALELVQQQ--GDEVDQVFV 120

Query: 178 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVD-STKYQLWYSSFPKVENDIRYS 236
           IGGG ++ E L   GC  +H T +  + ECD F P       +++   S  K EN +++ 
Sbjct: 121 IGGGAVYAEALAYVGCSKVHLTRVKGAFECDAFFPLEQLEQNFEVTSESELKEENGVQFQ 180

Query: 237 FATYVRV--QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQ 294
           F    R   QS    +L+  T P                          HEE  YL LI+
Sbjct: 181 FVELERKTEQSVETTTLADATTP--------------------------HEEMQYLDLIR 214

Query: 295 EIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FP 328
           +I+++            LS FG QMRF+LR + FP
Sbjct: 215 KILTQGAKRGDRTGTGTLSVFGAQMRFSLRDNVFP 249


>F0W9B4_9STRA (tr|F0W9B4) Bifunctional dihydrofolate reductasethymidylate
           synthase 2 putative OS=Albugo laibachii Nc14
           GN=AlNc14C39G3381 PE=3 SV=1
          Length = 494

 Score =  142 bits (358), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 95/278 (34%), Positives = 132/278 (47%), Gaps = 42/278 (15%)

Query: 64  RTYQVVVAATKD-MGIGKDGKLPWRLFTDLKFFKEITTAT------SDPGKKNAIVMGRK 116
           RT  +VVAAT+D  GIG    +PW+L  DLK F+++TT T      +    +NA++MGRK
Sbjct: 3   RTISIVVAATEDCWGIGWRQSIPWKLAKDLKHFRDLTTRTFSFNGCNSQNMRNAVIMGRK 62

Query: 117 TWESIPLKYRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEK 174
           TWES+P  Y+PLP R N +LTR+ ++  D     +V I  S+               I +
Sbjct: 63  TWESLPPSYQPLPNRYNHILTRTTNYRIDHSVPHDVGISSSLADALEEIERQE---DIGR 119

Query: 175 VFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPP-VDSTKYQLWYSSFPKVENDI 233
           VF+IGG +++   L    C+ I+ T + A+ +CDTF P  +    +QL   S    EN+I
Sbjct: 120 VFIIGGQKVYEAALECTSCDRIYLTTVKATYQCDTFFPSNLKDRGFQLVSESDEMEENEI 179

Query: 234 RYSFATYVR--VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLR 291
           R+ F    R  V  +    L  N  P                          HEEY YL 
Sbjct: 180 RFHFRELSRPIVTITKHSGLYTNEKP--------------------------HEEYQYLN 213

Query: 292 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FP 328
           LI+ I++              S FG QMRFNLR   FP
Sbjct: 214 LIRNIVANGVEKQDRTGVGTKSIFGVQMRFNLRNDMFP 251


>R4G4F4_RHOPR (tr|R4G4F4) Putative dihydrofolate reductase OS=Rhodnius prolixus
           PE=2 SV=1
          Length = 184

 Score =  142 bits (357), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 70/180 (38%), Positives = 109/180 (60%), Gaps = 5/180 (2%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + V+VAA ++ GIG  G LPWRL  ++ +F ++T+ T++P KKNA++MGRKTWESIP K+
Sbjct: 5   FNVIVAACENNGIGIKGDLPWRLKNEMAYFTKMTSQTTNPEKKNAVIMGRKTWESIPPKF 64

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           +PL GRLNVVL++  +      E+ VI  ++          PY  +IE  +VIGG  +++
Sbjct: 65  KPLKGRLNVVLSK--TLKETNYEDAVIFDNLSNAMSQLIHPPYSNNIENFWVIGGASVYK 122

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP---KVENDIRYSFATYVR 242
           E + +  C  I+ T+I+   +CDTF P + ST  Q+     P   + E D+ Y F  + +
Sbjct: 123 EAVLSDMCHRIYLTQINKCFDCDTFFPDIPSTFLQVSDKEVPDDVQEEKDLTYQFKVFEK 182


>M4BX13_HYAAE (tr|M4BX13) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Hyaloperonospora arabidopsidis (strain
           Emoy2) PE=3 SV=1
          Length = 494

 Score =  141 bits (356), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 94/275 (34%), Positives = 138/275 (50%), Gaps = 36/275 (13%)

Query: 64  RTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKK-NAIVMGRKTWESI 121
           R   V+VAA + + GIG   K+PW L TD+K F+ +TT+  DP K+ +A++MGRKTWES+
Sbjct: 4   RALSVIVAALETNGGIGLQQKIPWHLPTDMKHFRALTTSRCDPLKQQHAVIMGRKTWESL 63

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENV--VICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           P   RPLP R NV+LTR  S+   T EN+   +  +                +++VFVIG
Sbjct: 64  PTAVRPLPKRYNVILTRDLSYR--TRENIPDTVGVAASFSEALKLVELQGEKVDQVFVIG 121

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMP-PVDSTKYQLWYSSFPKVENDIRYSFA 238
           G  ++ E L    C+ +  T +    +CD F P  +   K+ +   S  K END+ + F 
Sbjct: 122 GSAVYAESLAHSECKKVFLTRVKGEFKCDAFFPLELLKQKFTVTNESEIKKENDVEFQFV 181

Query: 239 TYVRVQS----SAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQ 294
            + R  +    +A E+L+     + DN +                    HEE  YL LIQ
Sbjct: 182 EWARNDTEEVIAAVETLA-----MADNTTS-------------------HEEMQYLDLIQ 217

Query: 295 EIISEXXXXXXXXXXXXLSKFGCQMRFNLR-RSFP 328
           +I+S+            LS FG QMRF+LR  +FP
Sbjct: 218 KILSQGVQRTDRTGTGTLSVFGAQMRFSLRNNAFP 252


>H3GWN7_PHYRM (tr|H3GWN7) Uncharacterized protein OS=Phytophthora ramorum PE=3
           SV=1
          Length = 493

 Score =  140 bits (353), Expect = 7e-31,   Method: Compositional matrix adjust.
 Identities = 93/278 (33%), Positives = 137/278 (49%), Gaps = 42/278 (15%)

Query: 63  QRTYQVVVAATKDMG-IGKDGKLPWRLFTDLKFFKEITTATSDPGK-KNAIVMGRKTWES 120
           +R+ +VVVAA +  G IG   ++PWRL +D+K F+ +TTA+  P   ++A++MGRKTWES
Sbjct: 4   ERSIRVVVAALESTGGIGLSQQIPWRLPSDMKRFRSLTTASPSPSSAQHAVIMGRKTWES 63

Query: 121 IPLKYRPLPGRLNVVLTRSGSF----DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVF 176
           +P K RP+P R NV+LTR  S+    D+   E V +  S                +++VF
Sbjct: 64  LPAKVRPMPKRYNVILTRDTSYRQRQDV--PEAVGVAASFHEALELVQQQ--EQEVDQVF 119

Query: 177 VIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVD-STKYQLWYSSFPKVENDIRY 235
           VIGGG ++ E L   GC  +H T +    ECD F P    +  +Q+ + S    EN +++
Sbjct: 120 VIGGGAVYGEALAYSGCHKVHLTRVKGQFECDAFFPSAQLAQNFQVTHESELMEENGVQF 179

Query: 236 SFATYVR----VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLR 291
            F  + R    V      +L   T P                          HEE  YL 
Sbjct: 180 QFVEWERKTEAVNGVGKTALVDATRP--------------------------HEEMQYLD 213

Query: 292 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FP 328
           LI++I+++            LS FG QMRF+LR + FP
Sbjct: 214 LIRKILTQGAKRGDRTGTGTLSVFGAQMRFSLRENVFP 251


>N6T381_9CUCU (tr|N6T381) Uncharacterized protein (Fragment) OS=Dendroctonus
           ponderosae GN=YQE_11309 PE=4 SV=1
          Length = 185

 Score =  137 bits (346), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 66/179 (36%), Positives = 105/179 (58%), Gaps = 10/179 (5%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           ++VAA+++ GIGK+G LPW+L  ++ FF+ +T+AT D  KKN ++MGR+TWESIP +++P
Sbjct: 7   LIVAASENWGIGKNGTLPWKLKKEMAFFRTMTSATEDKSKKNVVIMGRRTWESIPAQFKP 66

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LP R+N VL+RSG  ++    N     S            +    E V++IGG  +++E 
Sbjct: 67  LPNRINFVLSRSG-LNLDQYSNTQSFTSFREALDKLEESAFRQLYENVWIIGGSSLYKET 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATY 240
             +P    ++ T+IH   +CDTF+P +     ++   S P V      ENDI Y+F  +
Sbjct: 126 FRSPHFHRLYLTKIHKEFDCDTFLPALPGNLKEI---SDPAVTEDIQEENDIEYTFQVF 181


>F0YJX9_AURAN (tr|F0YJX9) Putative uncharacterized protein OS=Aureococcus
           anophagefferens GN=AURANDRAFT_38942 PE=3 SV=1
          Length = 510

 Score =  137 bits (345), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 94/278 (33%), Positives = 127/278 (45%), Gaps = 25/278 (8%)

Query: 58  PLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKT 117
           P  +L +   +V A     GIGKDG LPW+L  D+K+FK++T+A  + GK NA VMGRKT
Sbjct: 10  PTNDLPQLTCIVAAVAGSYGIGKDGTLPWKLAGDMKYFKKVTSAAPE-GKTNACVMGRKT 68

Query: 118 WESIPLKYRPLPGRLNVVLTR--SGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKV 175
           W SIP K+RPL GR NVVL+R  +   ++G   +V +C S+               + +V
Sbjct: 69  WLSIPPKFRPLGGRKNVVLSRNPNAREELGLPPDVFVCPSLDAAVDALAGE---ADLGEV 125

Query: 176 FVIGGGQIFREVLNAPGCEAIHFTEIH----ASIECDTFMPPVDSTKYQLWYSSFPKVEN 231
           FVIGGGQ++   L    C  +  T I     A  +CD   P      +    S    VEN
Sbjct: 126 FVIGGGQVYASALADARCTKVLLTSIDDAAGAFADCDAVFPDPAKAGFASAASGEALVEN 185

Query: 232 DIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLR 291
            + Y F T  R              PL ++N               +     HEE  YL 
Sbjct: 186 GVAYRFETLTR---------PAKKPPLRESNGPPAPPPANE-----KPAAPNHEEKQYLD 231

Query: 292 LIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRS-FP 328
           LI EI+              +S FG +M F+LR   FP
Sbjct: 232 LIAEILDRGVRRGDRTGTGTISIFGARMSFSLRNDRFP 269


>J3JTN2_9CUCU (tr|J3JTN2) Uncharacterized protein OS=Dendroctonus ponderosae PE=2
           SV=1
          Length = 185

 Score =  136 bits (342), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 66/180 (36%), Positives = 104/180 (57%), Gaps = 10/180 (5%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
            ++VAA+++ GIGK+G LPW+L  ++ FF+ +T+AT D  KKN ++MGR+TWESIP +++
Sbjct: 6   NLIVAASENWGIGKNGTLPWKLKKEMAFFRTMTSATEDKSKKNVVIMGRRTWESIPAQFK 65

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PLP R+N VL+RSG  ++    N     S            +    E V++IGG  ++ E
Sbjct: 66  PLPNRINFVLSRSG-LNLDQYSNTQSFTSFREALDKLEESTFRQLYENVWIIGGSSLYNE 124

Query: 187 VLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATY 240
              +P    ++ T+IH   +CDTF+P +     ++   S P V      ENDI Y+F  +
Sbjct: 125 TFRSPHFHRLYLTKIHKEFDCDTFLPALPGNLKEI---SDPAVTEDIQEENDIEYTFQVF 181


>F2U1R1_SALS5 (tr|F2U1R1) Putative uncharacterized protein OS=Salpingoeca sp.
           (strain ATCC 50818) GN=PTSG_02278 PE=3 SV=1
          Length = 187

 Score =  136 bits (342), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 69/163 (42%), Positives = 99/163 (60%), Gaps = 5/163 (3%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           VVVAAT   GIG+DG LPW+L  D+K F+++TT  + PGK+NA+++GR T+ESIP K+RP
Sbjct: 8   VVVAATLQWGIGRDGTLPWKLRGDMKHFRKVTTEAA-PGKRNAVIVGRATYESIPEKFRP 66

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L  R N+VL+ + +F      +V  C S                I+++ VIGG +  +E 
Sbjct: 67  LKNRWNIVLSSNTAFRDSLPADVASCSSFEDAVRLCQDKE---DIDRIMVIGGARCIKEA 123

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVE 230
           L  P C+ I FT + A + CDTF+ P+D   +Q    +FPKVE
Sbjct: 124 LQRPDCQHIFFTRVKAEVPCDTFIEPIDDKTFQE-NPAFPKVE 165


>A7SCT0_NEMVE (tr|A7SCT0) Predicted protein OS=Nematostella vectensis
           GN=v1g210271 PE=3 SV=1
          Length = 187

 Score =  135 bits (340), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 70/183 (38%), Positives = 97/183 (53%), Gaps = 7/183 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           +  +VA     GIGK+  LPW++  D+KFF E T+     GK+NA++MGRK WESIP K+
Sbjct: 8   FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPL GRLN+VL+R+ S      +   +C S           PY   IE VFV GG  +++
Sbjct: 68  RPLKGRLNIVLSRTLS---EPPQGAQLCRSFEQALTILSTDPYTKKIENVFVCGGSALYK 124

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS-SFPKVEND---IRYSFATYV 241
           + +    C  I+ T I    +CD F P  D   Y L      P V+++   I+Y F  Y 
Sbjct: 125 DAMAHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLVEDPDVPSVQHEEKGIKYKFCVYD 184

Query: 242 RVQ 244
           R Q
Sbjct: 185 RCQ 187


>K1P8X7_CRAGI (tr|K1P8X7) Viral dihydrofolate reductase OS=Crassostrea gigas
           GN=CGI_10006692 PE=3 SV=1
          Length = 197

 Score =  134 bits (338), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 69/188 (36%), Positives = 108/188 (57%), Gaps = 19/188 (10%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
            +VVAA  D GIGKDG+LPWRL  D++FFK++TT T +P KKN ++MGRKTW SIP K+R
Sbjct: 6   NLVVAACNDWGIGKDGQLPWRLKKDMEFFKKMTTQTDNPDKKNVVIMGRKTWNSIPEKFR 65

Query: 127 PLPGRLNVVLTR------SGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           PLP R+N++L++      +G++  G+ E  +                    +E + +IGG
Sbjct: 66  PLPKRINIILSKTMTHAPTGAYLAGSLEEAI--------SMVTDKGDLADKVEGIHIIGG 117

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS--SFPK---VENDIRY 235
             +++  + +     I+ T + A  +CDTF+P +DS  ++   +    PK    ENDI +
Sbjct: 118 SSVYKAAMESDFPCRIYLTRVLADFDCDTFLPQIDSNVFEKIDNCKEVPKGTVTENDIDF 177

Query: 236 SFATYVRV 243
            F  Y ++
Sbjct: 178 VFEVYDKI 185


>A8XF85_CAEBR (tr|A8XF85) Protein CBG12356 OS=Caenorhabditis briggsae GN=CBG12356
           PE=3 SV=1
          Length = 189

 Score =  133 bits (335), Expect = 7e-29,   Method: Compositional matrix adjust.
 Identities = 63/168 (37%), Positives = 94/168 (55%), Gaps = 2/168 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R   ++VA   + GIGK+G LPWR+  D+++F  +T   SDP K+NA++MGRK WESIP 
Sbjct: 2   RKMNMIVAMDTEGGIGKNGVLPWRIRKDMQYFAAVTKKVSDPAKRNAVLMGRKCWESIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPLPGRLN+VL+R    +    +N+++  S+          P+  SIE ++ IGG +I
Sbjct: 62  SRRPLPGRLNIVLSR--QLEKQNTDNLIVVNSLESALKLLSEAPFVDSIETIWNIGGAEI 119

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEN 231
           +   L     + IH T IH + E D  +  +D  K +    +    EN
Sbjct: 120 YDLALRENLVDEIHLTRIHKNFEADVHLKSLDFNKLKKIIDAEASSEN 167


>Q22KR8_TETTS (tr|Q22KR8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Tetrahymena thermophila (strain SB210)
           GN=TTHERM_00312120 PE=3 SV=1
          Length = 485

 Score =  133 bits (334), Expect = 9e-29,   Method: Compositional matrix adjust.
 Identities = 83/266 (31%), Positives = 127/266 (47%), Gaps = 28/266 (10%)

Query: 64  RTYQVVVAAT-KDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R + +V+A T K  GIG    LPWRL  +LK FK+ITT T + G +NA++MG+ TWE++P
Sbjct: 4   RHFDIVLAQTLKKQGIGYKNSLPWRLPNELKNFKKITTETKNKGLQNAVIMGKNTWEALP 63

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K +PL  RLN+V++ +   +   A++   C S+               I+   VIGG +
Sbjct: 64  KKQQPLKDRLNIVISTTMQ-EGQIADHSYACKSLDSALNFLEQQN---QIQDALVIGGAK 119

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           + ++ L+      IH T +   +ECD FM       + +   S  + EN++ Y F  Y  
Sbjct: 120 LCQQALSDQRLRQIHLTRVGVEVECDVFMQKDYLKNFDMIEVSETQSENNLNYDFTRYFN 179

Query: 243 VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXX 302
                 ++     DP                  L + + + H+EY YL LI EII     
Sbjct: 180 ------KNYKGQVDP-----------------SLFKKMYKPHQEYQYLELIDEIIKNGHV 216

Query: 303 XXXXXXXXXLSKFGCQMRFNLRRSFP 328
                    +S+FG  MRF+L +SFP
Sbjct: 217 KTDRTGTGTISQFGKLMRFDLSKSFP 242


>D3PJE0_9MAXI (tr|D3PJE0) Dihydrofolate reductase OS=Lepeophtheirus salmonis
           GN=DYR PE=2 SV=1
          Length = 180

 Score =  132 bits (332), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 76/181 (41%), Positives = 105/181 (58%), Gaps = 14/181 (7%)

Query: 65  TYQVVVAATKDM-GIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           T  V+ AA +   GIGK+  LPW L TDLK+FK  TT +S P  K A++MGR+TWESIP 
Sbjct: 7   TLHVIAAACRPTNGIGKNNTLPWNLPTDLKYFK--TTTSSTPDSKVAVIMGRRTWESIPS 64

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLS-IEKVFVIGGGQ 182
           K RPL  R+NVVLT + +F    AE  ++  S+            C+   +K+++IGG  
Sbjct: 65  KPRPLKNRINVVLTTNSNF---VAEGAILASSLEEGIKS------CMDQADKIWIIGGAN 115

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVR 242
           +++E +    C+ I  TEI    ECDTF P +DSTKY+    S   VEN I + F  + R
Sbjct: 116 LYKEAMQYYKCQ-IFLTEIDKEFECDTFFPSIDSTKYKEVSVSEDHVENGITFRFKRFER 174

Query: 243 V 243
           +
Sbjct: 175 L 175


>I7IGH8_BABMI (tr|I7IGH8) Chromosome II, complete genome OS=Babesia microti
           strain RI GN=BBM_II03680 PE=3 SV=1
          Length = 507

 Score =  132 bits (331), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 88/265 (33%), Positives = 137/265 (51%), Gaps = 17/265 (6%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATS-DPGKKNAIVMGRKTWESIPLKYR 126
           + A+T + GIG +GKLPW+ L  DLK  ++ITTA   D   +N ++MGRKT+ SIP   R
Sbjct: 9   IYASTPNGGIGNEGKLPWKTLPRDLKHLQDITTAYGPDHSVQNVVIMGRKTYISIPKSSR 68

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PL  R+N+VL+ S S D G  + V+   S+             +   K+F+IGG  +++E
Sbjct: 69  PLKDRINIVLSSSVS-DFG--DGVIAAKSMQDAFDKLEK----MKFNKIFIIGGSSVYKE 121

Query: 187 VLNAPGCEAIHFTEIHASIECDTFM---PPVDSTKYQLWYSSFPKVENDIRYSFATYVRV 243
             +    E ++ T ++  +  DTF+   PP+    +++   S     NDI + F  Y+  
Sbjct: 122 AYDLGIVEKVYVTRVNKELPADTFVTSVPPI----FEIVGISRTFSYNDIPFDFIIYMLK 177

Query: 244 QSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXX 303
            S A  ++  + D       +   F+ Q F  LP + +++HEE  YL +I +I+S     
Sbjct: 178 DSRATSNVCVDIDDYLLTEHEIRDFKYQ-FKALPNVTIRKHEEIQYLDIIADILSSGSEN 236

Query: 304 XXXXXXXXLSKFGCQMRFNLRRSFP 328
                   LSKFG +M FNL  SFP
Sbjct: 237 DDRTGVGVLSKFGYKMEFNLDESFP 261


>E9AKW4_LEIMU (tr|E9AKW4) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania mexicana (strain MHOM/GT/2001/U1103)
           GN=LMXM_06_0860 PE=3 SV=1
          Length = 520

 Score =  131 bits (329), Expect = 4e-28,   Method: Compositional matrix adjust.
 Identities = 88/282 (31%), Positives = 128/282 (45%), Gaps = 55/282 (19%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTW 118
           R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VMGRKTW
Sbjct: 25  RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTDKKRNAVVMGRKTW 84

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFD-----------IGTAENVVIC-GSIXXXXXXXXXX 166
           ES+P+K+RPL GRLNVVL+   + +              A+++V+  G +          
Sbjct: 85  ESVPVKFRPLKGRLNVVLSSKATVEELLAPLPEEKRAAAAQDIVVVNGGLAAALRLLARP 144

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDSTKYQLW 222
           PYC SIE  + +GG Q++ + + +P  E    ++ T IH +   C  F P          
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIHTTAPACTRFFP---------- 194

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
              FP       +  A+    + SA                D L+FE+  +      + +
Sbjct: 195 ---FPPENAATAWDLASSQGRRKSAV---------------DGLEFEICKY------VPR 230

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            HEE  YL LI  I+              LS FG QMRF+LR
Sbjct: 231 NHEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLR 272


>Q172I3_AEDAE (tr|Q172I3) AAEL007370-PA OS=Aedes aegypti GN=AAEL007370 PE=3 SV=1
          Length = 186

 Score =  130 bits (328), Expect = 5e-28,   Method: Compositional matrix adjust.
 Identities = 64/185 (34%), Positives = 107/185 (57%), Gaps = 7/185 (3%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           + + ++VA   + GIG  G LPWRL  +LK+F  +T   +D  K+NAI+MGRKT+  +P 
Sbjct: 2   KKFSLIVAVCANGGIGIKGDLPWRLRQELKYFSRMTKKITDTSKRNAIIMGRKTYFGVPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPLP RLN++LTR  S +   + +V++C S+          P    IEK++++GG  +
Sbjct: 62  SKRPLPERLNIILTRDPSANTYPS-DVMVCKSMQEALTKLDESPLANEIEKIWIVGGNAV 120

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP-----KVENDIRYSFA 238
           ++E + +  C  I+ TEI  + ECD F P + ++++QL  +        + EN I+Y + 
Sbjct: 121 YKEAMQSERCHRIYLTEIKETYECDAFFPEI-TSEFQLVKNDDDVPEEIQEENGIQYQYR 179

Query: 239 TYVRV 243
            Y ++
Sbjct: 180 IYEKL 184


>L7MJG0_9ACAR (tr|L7MJG0) Putative dihydrofolate reductase (Fragment)
           OS=Rhipicephalus pulchellus PE=2 SV=1
          Length = 214

 Score =  130 bits (326), Expect = 8e-28,   Method: Compositional matrix adjust.
 Identities = 69/182 (37%), Positives = 106/182 (58%), Gaps = 8/182 (4%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
            +VA  ++ GIG +  LPWRL  +L +F  +T   ++ GK+NA+VMGR TWES+P K RP
Sbjct: 37  AIVAMCRNRGIGVNNSLPWRLKKELAYFTRLTKEAAE-GKQNAVVMGRLTWESLPPKSRP 95

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L  R+N+V++++ + +I    +VV   S                ++KVFVIGG Q++RE+
Sbjct: 96  LSDRINIVVSKTLT-EIPEGHHVV--RSFADAVQTLQNLVDAGKVDKVFVIGGAQLYREL 152

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSF----PKVENDIRYSFATYVRV 243
           + +P C  I+ TEI    ECD F P  D+++++L         P+ E DI Y F  Y RV
Sbjct: 153 IESPHCSRIYLTEIDKEFECDVFFPEFDTSRFRLVKEEGVPEEPQQEGDITYHFRVYERV 212

Query: 244 QS 245
           ++
Sbjct: 213 KN 214


>K7IQX8_NASVI (tr|K7IQX8) Uncharacterized protein OS=Nasonia vitripennis PE=3
           SV=1
          Length = 184

 Score =  130 bits (326), Expect = 8e-28,   Method: Compositional matrix adjust.
 Identities = 62/187 (33%), Positives = 108/187 (57%), Gaps = 6/187 (3%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           +Q   +++ AA ++MGIG +G LPWRL  ++ FF ++T+ T D  KKN ++MGR+TWESI
Sbjct: 1   MQVKLKLIAAACENMGIGVNGDLPWRLRKEMDFFTKMTSTTKDENKKNVVLMGRRTWESI 60

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P K++PL  R+N+VLT S   D+G  E+ ++C ++          P    +E+V+VIGG 
Sbjct: 61  PKKFKPLSNRINMVLT-SQPLDLG--EDAIVCKNLPEAIEKISQSPLKDKVEQVWVIGGS 117

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP---KVENDIRYSFA 238
            +++  + +P    ++ T +    +CD F P + +    +     P   + E DI++ + 
Sbjct: 118 LVYKTSMESPNFYRLYLTRVKKDFKCDAFFPEIPNDYILVKDPEVPEGIQEEKDIKFEYE 177

Query: 239 TYVRVQS 245
            Y + Q+
Sbjct: 178 VYEKKQN 184


>M2Y9L6_GALSU (tr|M2Y9L6) Thymidylate synthase/dihydrofolate reductase
           OS=Galdieria sulphuraria GN=Gasu_03410 PE=3 SV=1
          Length = 503

 Score =  130 bits (326), Expect = 9e-28,   Method: Compositional matrix adjust.
 Identities = 90/283 (31%), Positives = 134/283 (47%), Gaps = 56/283 (19%)

Query: 67  QVVVAATKDM-GIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           ++VVA T++  GIG  GK+PW+L  DL+FFKE+T         N ++MGRKTWES+P   
Sbjct: 13  RIVVALTRNARGIGLLGKMPWKLKKDLQFFKELTLG-------NPVIMGRKTWESLPTAS 65

Query: 126 RPLPGRLNVVLTRSGSF------------DIGTAENVVI-CGSIXXXXXXXXXXPYCLSI 172
           +PL  RLNVVLT + +             D    E + + C S+           + ++ 
Sbjct: 66  KPLKKRLNVVLTSNPTLFQKNYLETLTDEDRTEEEGLCLACNSLESALNMLRLRSFPVA- 124

Query: 173 EKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND 232
              ++IGG Q+F E L  P C  ++ T I+    CDTF P + +  +QL  +S    EN 
Sbjct: 125 ---YIIGGRQVFEEALVNPACSRVYLTRIYEDFACDTFFPCLPNY-FQLVSNSEIFEENG 180

Query: 233 IRYSFATYVR-------VQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHE 285
           I++ F  Y R       +  ++A    QN +P                        + HE
Sbjct: 181 IKFEFLEYRRDMYLTTGMNENSAHGKRQNINP-----------------------SRPHE 217

Query: 286 EYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
           EY YL L+++I+ +            LS FG QMRF+L+  FP
Sbjct: 218 EYQYLELVRKIVEQGVFKNDRTGVGTLSLFGHQMRFSLQGQFP 260


>C5LQI2_PERM5 (tr|C5LQI2) Dihydrofolate reductase-thymidylate synthase, putative
           OS=Perkinsus marinus (strain ATCC 50983 / TXsc)
           GN=Pmar_PMAR025126 PE=3 SV=1
          Length = 492

 Score =  129 bits (325), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 91/260 (35%), Positives = 122/260 (46%), Gaps = 26/260 (10%)

Query: 68  VVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATS-DPGKKNAIVMGRKTWESIPLKY 125
           V+VA T   GIGKDG+LPW+ L  D+K FK+ITT    +   KN  +MGRKTWESIP ++
Sbjct: 8   VIVAHTCKWGIGKDGQLPWKSLPEDMKRFKKITTGGHCNDNVKNVCIMGRKTWESIPERF 67

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPL  R+NVV++ + S        V IC S+             + I ++FVIGG  +  
Sbjct: 68  RPLRDRINVVISSTTS-PTDYPPGVRICPSLLDSLASLQQGE--VEIGEIFVIGGASLIT 124

Query: 186 EVLNAPGCEAIHFTEIHAS-IECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQ 244
           E +  P C  ++ T +     ECD FM  +D   ++    S     +DI Y F  Y R +
Sbjct: 125 EAMQLPQCRTLYTTRVGTDPWECDVFMEKIDEKIWEPIAVSRTFRHSDIPYDFVDYKRRE 184

Query: 245 SSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXX 304
            S    LS              KF+              H EY YLRLI+EII       
Sbjct: 185 GSDKTELS------LAERCPRGKFQ--------------HGEYEYLRLIEEIIENGEDAD 224

Query: 305 XXXXXXXLSKFGCQMRFNLR 324
                   + F C MRF+LR
Sbjct: 225 DRTGVGTKTIFSCHMRFSLR 244


>Q6BTR6_DEBHA (tr|Q6BTR6) DEHA2C16456p OS=Debaryomyces hansenii (strain ATCC
           36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
           GN=DEHA2C16456g PE=3 SV=2
          Length = 206

 Score =  129 bits (325), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 61/146 (41%), Positives = 94/146 (64%), Gaps = 4/146 (2%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V A   ++GIG  GK+PWRL  ++K+FK +TT T DP   NA++MGRKTWESIP K+RP
Sbjct: 15  IVAALLPELGIGIKGKMPWRLRQEIKYFKNVTTTTKDPNGINAVIMGRKTWESIPTKFRP 74

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LPGRLN+VL+RS        E++++  SI           Y   +EK+FVIGG +++ ++
Sbjct: 75  LPGRLNIVLSRSYVSHGSNDEDIILTNSIENALAKVEE--YSKPVEKIFVIGGSELYNKL 132

Query: 188 LNAPGCEAIHFTEIHAS--IECDTFM 211
           ++    + +  TEI ++  +E DT++
Sbjct: 133 ISHEKVQHLLITEIKSTRPVEVDTWL 158


>B9WKH7_CANDC (tr|B9WKH7) Dihydrofolate reductase, putative OS=Candida
           dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 /
           NCPF 3949 / NRRL Y-17841) GN=DFR1 PE=3 SV=1
          Length = 192

 Score =  129 bits (324), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 69/159 (43%), Positives = 101/159 (63%), Gaps = 13/159 (8%)

Query: 68  VVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           ++VAA K  +GIG  GK+PWRL  ++++FK++TT T+ PG +NA++MGRKTWESIP K+R
Sbjct: 8   IIVAALKPALGIGYQGKMPWRLRKEIRYFKDVTTKTTRPGTRNAVIMGRKTWESIPQKFR 67

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PLP RLN++L+RS   +I   +N+V   SI               +E+VF+IGG +I+ E
Sbjct: 68  PLPDRLNIILSRSYKNEI-IDDNIVHASSIESSLN------LVSDVERVFIIGGAEIYNE 120

Query: 187 VLNAPGCEAIHFTEIH----ASIECDTFMP-PVDSTKYQ 220
           ++N      +  TEI      SIE DTF+  P++S   Q
Sbjct: 121 LINNSLVTHLLITEIEHPDPESIEMDTFLKFPLESWTKQ 159


>J7GQW2_BOMMO (tr|J7GQW2) Dihydrofolate reductase OS=Bombyx mori PE=2 SV=1
          Length = 185

 Score =  129 bits (323), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 64/182 (35%), Positives = 100/182 (54%), Gaps = 8/182 (4%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
            ++ AA ++MGIG +G LPW+L  ++ +F  +TT+ SD  K NA++MGR+TW+ IP+KYR
Sbjct: 7   NLIAAACENMGIGINGTLPWKLKKEMAYFTTMTTSVSDKNKVNAVIMGRRTWDCIPIKYR 66

Query: 127 PLPGRLNVVLTRSGSF-DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           PL  R+N+VLT +  +      E V++   +               IE  +VIGG  I++
Sbjct: 67  PLSNRINIVLTHNVDYVKKQVPEGVIVVPGLDEAIDHIDSRS---DIESTWVIGGSSIYK 123

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS----SFPKVENDIRYSFATYV 241
             +  P C  I+ TEI  S +CDTF P ++  ++ L          + E DI Y +  Y 
Sbjct: 124 AAMEHPNCGKIYLTEIQKSFDCDTFFPDINQQQFHLVNEEEVPGEKQSEGDINYYYRIYK 183

Query: 242 RV 243
           R+
Sbjct: 184 RL 185


>Q6WEA6_HARCA (tr|Q6WEA6) Dihydrofolate reductase OS=Hartmannella cantabrigiensis
           GN=DHFR PE=3 SV=1
          Length = 182

 Score =  129 bits (323), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 69/182 (37%), Positives = 104/182 (57%), Gaps = 7/182 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
           + +VVA TK MGIG  G LPW  +  D+ FFK+IT+ T D  K+NA+VMGRKT+  IP K
Sbjct: 4   FALVVAVTKTMGIGNKGGLPWSSIRGDMNFFKKITSETKDAAKQNAVVMGRKTYVGIPAK 63

Query: 125 YRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +RPL  R+N+V++ + +   +    ++V I  S           P   +IE VFVIGG  
Sbjct: 64  FRPLSNRVNIVISTNANLRKEESIPDSVHIVDSFDLAVTKAYNLP---NIENVFVIGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHA-SIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           ++ E +  P C+ I++T I      CDTF P ++ + +++   S  + E +  Y F TY 
Sbjct: 121 VYAEAMKHPQCKTIYYTNILTPDFTCDTFFPKIEESVFKVTSRSDLQQEGETSYEFLTYY 180

Query: 242 RV 243
           R+
Sbjct: 181 RI 182


>A4H4P8_LEIBR (tr|A4H4P8) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania braziliensis GN=LBRM_06_0830 PE=3 SV=1
          Length = 521

 Score =  129 bits (323), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 96/320 (30%), Positives = 144/320 (45%), Gaps = 70/320 (21%)

Query: 28  VSSSFCRFLSSM-MTGDSFVVXXXXXXXXXXPLPNLQRTYQVVVAATKDMGIGKDGKLPW 86
           +S +  RF   M +T DSF              P+L R + ++VA  +  GIG    +PW
Sbjct: 1   MSRAAARFKIPMSVTKDSFA------------FPSL-RCFSIIVAVDEQHGIGDGKTIPW 47

Query: 87  RLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGS 141
           ++  D+ FFK+ TT   +       K+NA+VMGR+TWES+PLKYRPL GRLNVVL+   +
Sbjct: 48  QVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRQTWESVPLKYRPLKGRLNVVLSSKAT 107

Query: 142 FD------------IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLN 189
            D                + VV+ G +          P+C SIE  + +GG Q++ + + 
Sbjct: 108 VDELLAALPEGKRTAAAQDLVVVNGGLAEALHLLARPPHCSSIETAYCVGGAQVYSDAMT 167

Query: 190 APGCEA---IHFTEIHASI-ECDTFMP-PVDSTKYQLWYSSFPKVENDIRYSFATYVRVQ 244
           AP  E    ++ T I+A+  EC  F P P  +     W         D+ +   T  R +
Sbjct: 168 APCVEKLQEVYLTRIYATAPECTRFYPFPPTNAAAAAW---------DLAW---TQGRQR 215

Query: 245 SSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXX 304
           S                 +  +++E++ +      +   HEE  YL LI  I+       
Sbjct: 216 SE----------------TGGVEYEIRKY------VPHNHEERQYLELIDRIMKTGIAKE 253

Query: 305 XXXXXXXLSKFGCQMRFNLR 324
                  LS FG QMRF+LR
Sbjct: 254 DRTGVGILSLFGAQMRFSLR 273


>C5MGL9_CANTT (tr|C5MGL9) Dihydrofolate reductase OS=Candida tropicalis (strain
           ATCC MYA-3404 / T1) GN=CTRG_05212 PE=3 SV=1
          Length = 194

 Score =  129 bits (323), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 61/149 (40%), Positives = 97/149 (65%), Gaps = 12/149 (8%)

Query: 68  VVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           ++VAA K  +GIG +GK+PWRL  ++++FK++T+ T+    +NA++MGRKTWESIP+K+R
Sbjct: 9   IIVAALKPSLGIGNNGKMPWRLRKEIRYFKDVTSKTTVENSRNAVIMGRKTWESIPVKFR 68

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PLP RLN++L+RS        EN +I  +I           +  +I++VF+IGG +I+ +
Sbjct: 69  PLPDRLNIILSRS-------YENEIIDENIIHANSVESSLSFMSNIDRVFIIGGAEIYND 121

Query: 187 VLNAPGCEAIHFTEIH----ASIECDTFM 211
           ++N P    +  TEI      S+E DTF+
Sbjct: 122 LINNPLVTQLLITEIEHSNPESVEMDTFL 150


>C5KZ80_PERM5 (tr|C5KZ80) Dihydrofolate reductase/thymidilate synthase, putative
           OS=Perkinsus marinus (strain ATCC 50983 / TXsc)
           GN=Pmar_PMAR018231 PE=4 SV=1
          Length = 422

 Score =  128 bits (322), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 93/269 (34%), Positives = 125/269 (46%), Gaps = 30/269 (11%)

Query: 59  LPNLQRTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATS-DPGKKNAIVMGRK 116
           LP L     V+VA T   GIGKDG+LPW+ L  D+K FK ITT    +   KN  +MGRK
Sbjct: 3   LPQLS----VIVAHTCKWGIGKDGQLPWKSLPEDMKRFKTITTGGHCNDDVKNVCIMGRK 58

Query: 117 TWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVF 176
           TWESIP ++RPL  R+NVV++ + S      + V IC S+             + I ++F
Sbjct: 59  TWESIPERFRPLKDRINVVISSTTS-PADYPQGVRICPSLLDSLASLQQGE--VKIGEIF 115

Query: 177 VIGGGQIFREVLNAPGCEAIHFTEIHAS-IECDTFMPPVDSTKYQLWYSSFPKVENDIRY 235
           VIGG  +  E +  P C  ++ T +     ECD FM  +D   ++    S     +DI +
Sbjct: 116 VIGGASLITEAMQLPQCRTLYTTRVGTDPWECDVFMEKIDEEIWEPIAVSRTFRHSDIPF 175

Query: 236 SFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQE 295
            F  Y R +              FD    SL        F       +H EY YLRLI+E
Sbjct: 176 DFVDYKRREG-------------FDKTELSLAERCPRGKF-------QHGEYEYLRLIEE 215

Query: 296 IISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           II               + F C MRF+LR
Sbjct: 216 IIENGEDADDRTGVGTKTIFSCHMRFSLR 244


>H9JUX7_BOMMO (tr|H9JUX7) Uncharacterized protein OS=Bombyx mori PE=3 SV=1
          Length = 185

 Score =  128 bits (322), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 64/182 (35%), Positives = 100/182 (54%), Gaps = 8/182 (4%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
            ++ AA ++MGIG +G LPW+L  ++ +F  +TT+ SD  K NA++MGR+TW+ IP+KYR
Sbjct: 7   NLIAAACENMGIGINGTLPWKLKKEMAYFTTMTTSVSDKKKVNAVIMGRRTWDCIPIKYR 66

Query: 127 PLPGRLNVVLTRSGSF-DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           PL  R+N+VLT +  +      E V++   +               IE  +VIGG  I++
Sbjct: 67  PLSNRINIVLTHNVDYVKKQVPEGVIVVPGLDEAIDHIDSRS---DIESTWVIGGSSIYK 123

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS----SFPKVENDIRYSFATYV 241
             +  P C  I+ TEI  S +CDTF P ++  ++ L          + E DI Y +  Y 
Sbjct: 124 AAMEHPNCGKIYLTEIQKSFDCDTFFPDINKQRFHLVNEEEVPGEKQSEGDINYYYRIYK 183

Query: 242 RV 243
           R+
Sbjct: 184 RL 185


>A3LSL9_PICST (tr|A3LSL9) Dihydrofolate reductase OS=Scheffersomyces stipitis
           (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
           Y-11545) GN=DFR1 PE=3 SV=2
          Length = 203

 Score =  128 bits (322), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 75/180 (41%), Positives = 109/180 (60%), Gaps = 17/180 (9%)

Query: 59  LPNLQRTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKT 117
           +  ++ T  ++VAA K D+ IG  GK+PWRL  ++++FK++TT TSDP K NA+VMGRKT
Sbjct: 1   MSEIKPTIAIIVAALKPDLAIGFQGKMPWRLRKEIRYFKDVTTKTSDPSKINAVVMGRKT 60

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFDIGTAE-NVVICGSIXXXXXXXXXXPYCLSIEKVF 176
           W+SIP ++RPLP R+N+VL+R  SF   T + NV+   SI              ++E+VF
Sbjct: 61  WDSIPARFRPLPDRINIVLSR--SFQNETVDTNVIHANSIANSLSQLQP-----NVERVF 113

Query: 177 VIGGGQIFREVLNAPGCEAIHFTEIHAS-----IECDTFMP-PVDSTKYQLWYSSFPKVE 230
           VIGG +I+ E++N      +  TEI  +     I  DTF+  P+ ST  Q  +   PK E
Sbjct: 114 VIGGAEIYNELINDSRVTHLLLTEIENTNEDNQIAVDTFLKFPLYSTDSQ--WRKQPKSE 171


>Q5A5E0_CANAL (tr|Q5A5E0) Putative uncharacterized protein DFR1 OS=Candida
           albicans (strain SC5314 / ATCC MYA-2876) GN=DFR1 PE=3
           SV=1
          Length = 192

 Score =  128 bits (321), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 67/159 (42%), Positives = 98/159 (61%), Gaps = 13/159 (8%)

Query: 68  VVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           ++VAA K  +GIG  GK+PWRL  ++++FK++TT T+ P  +NA++MGRKTWESIP K+R
Sbjct: 8   IIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFR 67

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PLP RLN++L+RS        EN +I  +I               +E+VF+IGG +I+ E
Sbjct: 68  PLPDRLNIILSRS-------YENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE 120

Query: 187 VLNAPGCEAIHFTEIH----ASIECDTFMP-PVDSTKYQ 220
           ++N      +  TEI      SIE DTF+  P++S   Q
Sbjct: 121 LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQ 159


>G1UAH9_CANAX (tr|G1UAH9) Putative uncharacterized protein CaJ7.0360 OS=Candida
           albicans GN=DFR1 PE=3 SV=1
          Length = 192

 Score =  128 bits (321), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 67/159 (42%), Positives = 98/159 (61%), Gaps = 13/159 (8%)

Query: 68  VVVAATK-DMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           ++VAA K  +GIG  GK+PWRL  ++++FK++TT T+ P  +NA++MGRKTWESIP K+R
Sbjct: 8   IIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFR 67

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PLP RLN++L+RS        EN +I  +I               +E+VF+IGG +I+ E
Sbjct: 68  PLPDRLNIILSRS-------YENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE 120

Query: 187 VLNAPGCEAIHFTEIH----ASIECDTFMP-PVDSTKYQ 220
           ++N      +  TEI      SIE DTF+  P++S   Q
Sbjct: 121 LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQ 159


>B4K681_DROMO (tr|B4K681) GI23507 OS=Drosophila mojavensis GN=Dmoj\GI23507 PE=3
           SV=1
          Length = 188

 Score =  127 bits (320), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 5/176 (2%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           Y ++VA  ++ GIG  G LPWRL ++LK+F   T   +DP K+N ++MGRKT+  +P   
Sbjct: 4   YNLIVAVCENFGIGFKGDLPWRLKSELKYFSRRTKRINDPSKRNVVIMGRKTYFGVPPSK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPLP RLN+VL+ + +      E V++CGS+          P C  +E ++++GG  ++ 
Sbjct: 64  RPLPDRLNIVLSTTLT-QKELPEGVLLCGSLDEAMQTLEKKPLCDQVENIWIVGGSGVYA 122

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP----KVENDIRYSF 237
           E + +P C  ++ T+I    ECDTF P + ++ +++  +       + EN I++ +
Sbjct: 123 EAMESPRCHRLYITKIQERFECDTFFPHIPASFHEVELTEDTPHGVQEENGIKFEY 178


>K0T9B5_THAOC (tr|K0T9B5) Uncharacterized protein OS=Thalassiosira oceanica
           GN=THAOC_04721 PE=3 SV=1
          Length = 1016

 Score =  127 bits (320), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 86/276 (31%), Positives = 128/276 (46%), Gaps = 41/276 (14%)

Query: 73  TKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRL 132
           +K  GIG  G+LPWRL  D+K FK++TT     G  NA++MGRKTWESIP K+RPL GR+
Sbjct: 85  SKSRGIGHKGELPWRLPGDMKHFKKVTTTPPSAGLTNAVIMGRKTWESIPSKFRPLDGRI 144

Query: 133 NVVLTRSGSFD----IGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVL 188
           NV+L+RSGS      +  +  V++  S+               +   FVIGGG+I+ + +
Sbjct: 145 NVILSRSGSAAPPERLSESSPVIVATSLEQAMARIEARS---DVGSTFVIGGGEIYNQAV 201

Query: 189 NAPGCEAIHFTEIHA---SIECDTFMPPVDSTKYQLWYSSFP-----------KVE---- 230
            +     + +T +       E D F P +   +++      P           KVE    
Sbjct: 202 ESGLVSRVVYTNVKGLPDDAEFDAFFPEMGEGEWECVPYCAPGEDGERAPKKAKVEEQTD 261

Query: 231 --NDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYM 288
             + +RY F  YVR  +  A ++S  ++                 D +PE      EE  
Sbjct: 262 AKSGLRYEFLEYVRRDADIAPAVSMESE--------------TTEDAIPEGPEVNPEEMQ 307

Query: 289 YLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           YL + ++II               SKFG QMR++LR
Sbjct: 308 YLDICRDIIENGVQRGDRTGTGTKSKFGVQMRYSLR 343


>Q8MXB7_LEITR (tr|Q8MXB7) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania tropica GN=dhfr-ts PE=3 SV=1
          Length = 520

 Score =  127 bits (320), Expect = 5e-27,   Method: Compositional matrix adjust.
 Identities = 85/282 (30%), Positives = 126/282 (44%), Gaps = 55/282 (19%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTW 118
           R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VMGRKTW
Sbjct: 25  RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRKTW 84

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFD------------IGTAENVVICGSIXXXXXXXXXX 166
           ES+P+K+RPL GRLN+VL+   + +                + VV+ G +          
Sbjct: 85  ESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEEKRAAAEQDVVVVNGGLAEALRLLARP 144

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDSTKYQLW 222
           PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P          
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 194

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
              FP       +  A+    + S AE                L+FE+  +      + +
Sbjct: 195 ---FPPENAATAWDLASSQGRRKSEAE---------------GLEFEICKY------VPR 230

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            HEE  YL LI  I+              +S FG QMRF+LR
Sbjct: 231 NHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLR 272


>Q8MXB8_LEITR (tr|Q8MXB8) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania tropica GN=dhfr-ts PE=3 SV=1
          Length = 520

 Score =  127 bits (320), Expect = 5e-27,   Method: Compositional matrix adjust.
 Identities = 85/282 (30%), Positives = 126/282 (44%), Gaps = 55/282 (19%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTW 118
           R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VMGRKTW
Sbjct: 25  RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRKTW 84

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFD------------IGTAENVVICGSIXXXXXXXXXX 166
           ES+P+K+RPL GRLN+VL+   + +                + VV+ G +          
Sbjct: 85  ESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEEKRAAAEQDVVVVNGGLAEALRLLARP 144

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDSTKYQLW 222
           PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P          
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 194

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
              FP       +  A+    + S AE                L+FE+  +      + +
Sbjct: 195 ---FPPENAATAWDLASSQGRRKSEAE---------------GLEFEICKY------VPR 230

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            HEE  YL LI  I+              +S FG QMRF+LR
Sbjct: 231 NHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLR 272


>G0UQH6_TRYCI (tr|G0UQH6) Putative uncharacterized protein TCIL3000_7_4510
           (Fragment) OS=Trypanosoma congolense (strain IL3000)
           GN=TCIL3000_7_4510 PE=4 SV=1
          Length = 343

 Score =  127 bits (319), Expect = 6e-27,   Method: Compositional matrix adjust.
 Identities = 92/286 (32%), Positives = 136/286 (47%), Gaps = 51/286 (17%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGR 115
           + R + +VVAA ++ GIG++G +PW +  D+K FK +TT      A     ++NA+VMGR
Sbjct: 25  VMRPFSIVVAADENGGIGENGTIPWEIPEDMKHFKNLTTKIRGKNAKPSLTRRNAVVMGR 84

Query: 116 KTWESIPLKYRPLPGRLNVVLTRSGSFDI-----------GTAEN--VVICGSIXXXXXX 162
           KTW+S+P K+RPL  RLNVVL+RS + +              AEN  +VI G +      
Sbjct: 85  KTWDSLPAKFRPLSNRLNVVLSRSATKEKLLAEIPEPSKREAAENDILVINGGLSDALKV 144

Query: 163 XXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIH-ASIECDTFMPPVDSTK 218
               PY  SIE V+ IGGG ++ E +++P  EA   +H T +  AS  C+ F        
Sbjct: 145 LVQSPYISSIETVYCIGGGTLYSEAISSPCVEALQAVHRTVVRPASESCNVFF------- 197

Query: 219 YQLWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPE 278
                   P   ++   S    VR      ES+   T+    +     K++ +       
Sbjct: 198 ------KLPTTHSNESESAMELVR------ESV---TEERVSSGCGGRKYQFE------R 236

Query: 279 MILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           ++ +  EE  YL L+  II              LS FG QMRF+LR
Sbjct: 237 LVPRNREEEQYLNLVDRIIKTGHSKCDRTGVGTLSIFGAQMRFSLR 282


>A5B4I5_VITVI (tr|A5B4I5) Putative uncharacterized protein OS=Vitis vinifera
            GN=VITISV_038665 PE=3 SV=1
          Length = 1562

 Score =  127 bits (319), Expect = 6e-27,   Method: Compositional matrix adjust.
 Identities = 62/98 (63%), Positives = 72/98 (73%), Gaps = 1/98 (1%)

Query: 103  SDPGK-KNAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXX 161
            SDP + KN ++MGRKTWESIPL++ PL  RLNV+LTR  SFDI TAENVVIC S+     
Sbjct: 1465 SDPRRTKNVVIMGRKTWESIPLEHWPLRNRLNVILTRPRSFDIATAENVVICRSMAAALE 1524

Query: 162  XXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEAIHFT 199
                 PYCLSIEKVFVIG GQI +E L+APG +AIH  
Sbjct: 1525 LLATSPYCLSIEKVFVIGSGQILKEGLDAPGRDAIHIA 1562


>G0TZ26_TRYVY (tr|G0TZ26) Putative dihydrofolate reductase-thymidylate synthase
           OS=Trypanosoma vivax (strain Y486) GN=TVY486_0705520
           PE=3 SV=1
          Length = 527

 Score =  126 bits (317), Expect = 8e-27,   Method: Compositional matrix adjust.
 Identities = 91/287 (31%), Positives = 131/287 (45%), Gaps = 58/287 (20%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + V+VA  ++ GIG    +PW L  D++FFK+ TT      AT  P K+NA+VMGRKT
Sbjct: 27  RAFSVIVATDENGGIGDGTSIPWNLPEDMQFFKKTTTRLRGKNATPSPQKRNAVVMGRKT 86

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFDI-------------GTAENVVICGSIXXXXXXXX 164
           WES+P K+RPL  RLNVVL+R+ + +                ++ +V+ G +        
Sbjct: 87  WESLPAKFRPLSNRLNVVLSRAATKEQLLAGIPSPSKRQEAESDVLVVNGGLSDALKLLV 146

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIE-CDTFMPPVDSTKYQ 220
             PY  S+E V+ IGGG I+ E +  P     +AI+ T +    E C+ F          
Sbjct: 147 QPPYTSSVETVYCIGGGSIYAEAIQQPCVDVLQAIYRTLVRTRAESCNVF---------- 196

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAES---LSQNTDPLFDNNSDSLKFEVQNFDFLP 277
                           F    +  S+AAE        T+ L    S   K++ +      
Sbjct: 197 ----------------FHLPSKGTSNAAEREWVRESITEELTSTGSSGTKYQFE------ 234

Query: 278 EMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 235 KLIPRNTEEEQYLNLVSRIIKEGNVKEDRTGVGTLSLFGAQMRFSLR 281


>Q6WEA4_HARCA (tr|Q6WEA4) Dihydrofolate reductase OS=Hartmannella cantabrigiensis
           GN=DHFR PE=3 SV=1
          Length = 182

 Score =  126 bits (317), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 69/182 (37%), Positives = 101/182 (55%), Gaps = 7/182 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
           + +VVA TK MGIG  G LPW  +  D+ FFK+IT+ T D  K+NA++MGRKT+  IP K
Sbjct: 4   FALVVAVTKTMGIGNKGGLPWSSIRGDMNFFKKITSETKDAAKQNAVIMGRKTYVGIPAK 63

Query: 125 YRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +RPL  R+N+V+  + +   +    ++V I  S           P   +IE VFVIGG  
Sbjct: 64  FRPLSNRVNIVIFTNANLRKEESIPDSVHIVDSFELAVTKAYSLP---NIENVFVIGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHA-SIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           ++ E +  P C+ I +T I      CDTF P ++   +++   S  + E +  Y F TY 
Sbjct: 121 VYAEAMKHPQCKTIFYTNILTPDFTCDTFFPKIEENVFKVTSRSDLQXEGETSYEFLTYS 180

Query: 242 RV 243
           RV
Sbjct: 181 RV 182


>B7FQJ9_PHATC (tr|B7FQJ9) Predicted protein (Fragment) OS=Phaeodactylum
           tricornutum (strain CCAP 1055/1) GN=PHATRDRAFT_1690 PE=3
           SV=1
          Length = 495

 Score =  126 bits (316), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 88/282 (31%), Positives = 123/282 (43%), Gaps = 58/282 (20%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           VV AA    GIG  G LPWRL  DL+ F+ +TT   + G  NA++MGRKTW+SIP ++RP
Sbjct: 1   VVAAAASHRGIGYQGSLPWRLPGDLRHFQAVTTQPPETGGTNAVIMGRKTWDSIPDRFRP 60

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LPGR+NVVLTR     +    + V+  +           P   ++  VFVIGGGQ++ + 
Sbjct: 61  LPGRINVVLTRHPERTL--WPDGVLTATSLADAAALLAQP-TRAVGHVFVIGGGQVYEQA 117

Query: 188 LNAPGCEAIHFTEIH---ASIECDTFMPPVDSTKYQ----------------------LW 222
           L       + +TE+    A  + D F PP+   ++Q                       W
Sbjct: 118 LREKFVNRVVYTEVANLPADSKFDAFFPPLPDAEWQAQPWQTSTTATNKENGNAPETGAW 177

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
           ++  P   + I Y F  Y R  +S          P  D N+                   
Sbjct: 178 HTDGP---SGITYRFLEYTRKVASV------TVQPPTDGNA------------------- 209

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
             EE  YL L + I+              LS+FG QMRF+LR
Sbjct: 210 --EERQYLDLCRHILDHGVRRGDRTGTGTLSQFGTQMRFSLR 249


>Q6WEA8_HARCA (tr|Q6WEA8) Dihydrofolate reductase OS=Hartmannella cantabrigiensis
           GN=DHFR PE=3 SV=1
          Length = 182

 Score =  126 bits (316), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 67/182 (36%), Positives = 102/182 (56%), Gaps = 7/182 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
           + +VVA TK MGIG  G LPW  +  D+ F K+IT+ T D  K+NA++MGRKT+  IP K
Sbjct: 4   FALVVAVTKTMGIGNKGGLPWSSIRGDMNFLKKITSETKDAAKQNAVIMGRKTYVGIPAK 63

Query: 125 YRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +RPL  R+N+V++ + +   +    ++V I  S           P   +IE VFVIGG  
Sbjct: 64  FRPLSNRVNIVISTNANLRKEESIPDSVHIVDSFDLAVTKAYNLP---NIENVFVIGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHA-SIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           ++ E +  P C+ I++T I      CDTF P ++   +++   S  + E +  Y F TY 
Sbjct: 121 VYAEAMKHPQCKTIYYTNILTPDFTCDTFFPKIEENVFKVTSRSDLQQEGETSYEFLTYY 180

Query: 242 RV 243
           R+
Sbjct: 181 RI 182


>B5YMV7_THAPS (tr|B5YMV7) Possible thymidylate synthase (Fragment)
           OS=Thalassiosira pseudonana GN=TMS1 PE=3 SV=1
          Length = 516

 Score =  125 bits (314), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 86/279 (30%), Positives = 131/279 (46%), Gaps = 35/279 (12%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           VV AA    GIG  GKLPWRL  D+  FK++TT    PG  NA++MGRKTW+SIP K+RP
Sbjct: 1   VVAAAAGSRGIGHQGKLPWRLPGDMNHFKKVTTTPPSPGLTNAVIMGRKTWDSIPSKFRP 60

Query: 128 LPGRLNVVLTRSGSFDI-------------GTAENVVICGSIXXXXXXXXXXPYCLSIEK 174
           L GR+NV+L+R  +  +               AE+V++  S+              S   
Sbjct: 61  LDGRVNVILSRKSAAGVEGVPMSTDDNNNNNNAEDVLVASSLEEAMQKLDGRANHGS--- 117

Query: 175 VFVIGGGQIFREVLNAPGCEAIHFTEIHASIE---CDTFMPPVDSTKYQLWYSSFPKVEN 231
            F+IGGG+I+ + + +   + + +T +    E    D F P +  ++++      PK   
Sbjct: 118 TFIIGGGEIYSQGIKSGLVKRVIYTNVKGLAEDAKLDAFFPELTDSEWEC-VPFTPKDNA 176

Query: 232 DIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEV------QNFDFLPEMILQRHE 285
           +   +   +V  ++  AE          ++    LK+E        N D +PE      E
Sbjct: 177 ENEETENNHVSKKAKVAEE--------HEDAKSGLKYEFLEYIRRDNVD-IPEGADVNPE 227

Query: 286 EYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           E  YL + ++II              LSKFG QMR++LR
Sbjct: 228 EMQYLEICRDIIENGVRRGDRTGTGTLSKFGVQMRYSLR 266


>I1BWH0_RHIO9 (tr|I1BWH0) Dihydrofolate reductase OS=Rhizopus delemar (strain RA
           99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)
           GN=RO3G_05255 PE=3 SV=1
          Length = 195

 Score =  125 bits (313), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 60/160 (37%), Positives = 93/160 (58%), Gaps = 5/160 (3%)

Query: 63  QRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTAT-SDPGKKNAIVMGRKTWESI 121
           QR   ++ AAT+++GIG+ G LPW L  DL++F+++TT        +N ++MGR TWESI
Sbjct: 3   QRKLALIAAATEELGIGRKGDLPWHLPRDLRYFRDVTTKIPKGNSAQNVVIMGRVTWESI 62

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAE-NVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           P KYRPL  R N+V++R+ ++D+ T + N ++  S               +  +VFV+GG
Sbjct: 63  PPKYRPLDNRFNIVVSRNPNYDLQTTDPNAILVTSFEEALEKIDATK---TNPRVFVVGG 119

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQ 220
            Q++   +    C  I  T+I A IECD F P +D   Y+
Sbjct: 120 AQLYSHAIKRADCTDILLTKIKAKIECDAFFPKIDEHVYR 159


>B4M4D4_DROVI (tr|B4M4D4) GJ10259 OS=Drosophila virilis GN=Dvir\GJ10259 PE=3 SV=1
          Length = 186

 Score =  125 bits (313), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 65/178 (36%), Positives = 100/178 (56%), Gaps = 7/178 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           Y ++VA  ++ GIG  G LPWRL ++LK+F   T  T DP K+N ++MGRKT+  +P   
Sbjct: 4   YNLIVAVCENFGIGLKGDLPWRLKSELKYFSRTTKRTRDPAKRNVVIMGRKTYFGVPPSK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXX--XXXXXPYCLSIEKVFVIGGGQI 183
           RPLP RLN+VL+ + S       +V++C S+            P+C  IE ++++GG  +
Sbjct: 64  RPLPDRLNIVLSTTMS-RAELPNDVLLCRSLEEAMKMLESESEPWCDQIENIWIVGGSGV 122

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMP--PVDSTKYQLWYSSFPKV--ENDIRYSF 237
           + E + +P C  ++ T+I    ECDTF P  P D  +  L   +   V  EN I+Y +
Sbjct: 123 YEEAMASPRCYRLYITKIQEQFECDTFFPNIPADFHEVPLDEDTPHGVQEENGIKYEY 180


>H2XNW6_CIOIN (tr|H2XNW6) Uncharacterized protein OS=Ciona intestinalis
           GN=LOC100182410 PE=3 SV=1
          Length = 194

 Score =  124 bits (311), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 65/181 (35%), Positives = 104/181 (57%), Gaps = 11/181 (6%)

Query: 69  VVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDP--GKKNAIVMGRKTWESIPLKYR 126
           VVA   + GIG  G+LPWRL  ++K+FK ITT   +   G++N +++GRKTWESIP  ++
Sbjct: 11  VVACCNNGGIGFKGRLPWRLPKEMKYFKRITTGEVEEFGGRRNVVIIGRKTWESIPKSFK 70

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PL  R+N+V++R+   D    + VV   S+          P+C  I +VF IGG +I++ 
Sbjct: 71  PLKDRINIVISRTLDKDCEGPDLVV--NSLDELIDLLHSKPWCDKINQVFNIGGNEIYKL 128

Query: 187 VLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV-------ENDIRYSFAT 239
           + N+  C  I+ T + A ++CDTF+  +D    +L    FP+V       +ND+++    
Sbjct: 129 IHNSQYCGKIYLTRVLADLQCDTFLENLDDNFTKLPTEGFPEVPQGIQMDKNDLQWKVEV 188

Query: 240 Y 240
           Y
Sbjct: 189 Y 189


>A2BGQ1_DANRE (tr|A2BGQ1) Uncharacterized protein OS=Danio rerio GN=dhfr PE=3
           SV=1
          Length = 190

 Score =  124 bits (311), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 71/202 (35%), Positives = 108/202 (53%), Gaps = 32/202 (15%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKTW 118
           + R    +VA   DMGIGK+G LPW   RL  +LK F+++T   SD GKKN ++MGRKTW
Sbjct: 1   MSRILNCIVAVCPDMGIGKNGNLPWHPIRLSNELKHFQKMTMTPSDEGKKNVVIMGRKTW 60

Query: 119 ESIPLKYRPLPGRLNVVLTR------SGSF----DIGTAENVVICGSIXXXXXXXXXXPY 168
            SIP  +RPL  R+N+VL+R       G+     D  +A +++  G +            
Sbjct: 61  FSIPAAHRPLKNRINIVLSRELKTAPEGAHYLASDFSSALHLLDSGELEKL--------- 111

Query: 169 CLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPK 228
              +++V++IGG  +++EV+   G   +  T I    +CDTF+P  D  KY+L    FP 
Sbjct: 112 ---VDQVWIIGGSSLYKEVMERSGHRRLFVTRILKQFDCDTFIPNFDMDKYKL-LPEFPG 167

Query: 229 V------ENDIRYSFATYVRVQ 244
           V      +N ++Y F  Y  ++
Sbjct: 168 VPVGLQEDNGVQYVFEVYESIE 189


>C1C2C0_9MAXI (tr|C1C2C0) Dihydrofolate reductase OS=Caligus clemensi GN=DYR PE=2
           SV=1
          Length = 178

 Score =  124 bits (310), Expect = 6e-26,   Method: Compositional matrix adjust.
 Identities = 68/175 (38%), Positives = 99/175 (56%), Gaps = 12/175 (6%)

Query: 67  QVVVAATKD-MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
            V+ AA K   GIGKD  LPW+L TD+K+F+E T +T++   +  ++MGR+TWES+P K+
Sbjct: 10  NVIAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEI--RVGVIMGRRTWESVPPKF 67

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RP   R NVVLT    F+   A+  VI  ++              +++ ++VIGG  ++ 
Sbjct: 68  RPFKNRFNVVLTSREDFE---AKGAVIARTLEDAVKKCSN-----NVDSIWVIGGSGVYA 119

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATY 240
           E LN   C  ++ TEI    +CD F PP+D  KY+L   S    ENDI + F  Y
Sbjct: 120 EALNKYPCR-VYLTEIDKEFDCDAFFPPLDEKKYKLASVSPDHQENDITFRFKVY 173


>Q6IQS4_DANRE (tr|Q6IQS4) Dihydrofolate reductase OS=Danio rerio GN=dhfr PE=2
           SV=1
          Length = 190

 Score =  123 bits (309), Expect = 8e-26,   Method: Compositional matrix adjust.
 Identities = 71/202 (35%), Positives = 108/202 (53%), Gaps = 32/202 (15%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKTW 118
           + R    +VA   DMGIGK+G LPW   RL  +LK F+++T   SD GKKN ++MGRKTW
Sbjct: 1   MSRILNCIVAVCPDMGIGKNGNLPWHPIRLSNELKHFQKMTMTPSDEGKKNVVIMGRKTW 60

Query: 119 ESIPLKYRPLPGRLNVVLTR------SGSF----DIGTAENVVICGSIXXXXXXXXXXPY 168
            SIP  +RPL  R+N+VL+R       G+     D  +A +++  G +            
Sbjct: 61  FSIPAAHRPLKNRINIVLSRELKTAPEGAHYLASDFSSALHLLDSGELEKL--------- 111

Query: 169 CLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPK 228
              +++V++IGG  +++EV+   G   +  T I    +CDTF+P  D  KY+L    FP 
Sbjct: 112 ---VDQVWIIGGSSLYKEVMERSGHRRLFVTRILKQFDCDTFIPNFDMDKYKL-LPEFPG 167

Query: 229 V------ENDIRYSFATYVRVQ 244
           V      +N ++Y F  Y  ++
Sbjct: 168 VPVGLQEDNGVQYLFEVYESIK 189


>H3IEF6_STRPU (tr|H3IEF6) Uncharacterized protein OS=Strongylocentrotus
           purpuratus PE=3 SV=1
          Length = 189

 Score =  123 bits (309), Expect = 8e-26,   Method: Compositional matrix adjust.
 Identities = 63/171 (36%), Positives = 99/171 (57%), Gaps = 10/171 (5%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIG +G LPWRL  ++ +F+ +T      G KNA++MGRKTW+SIP K+RPL  R+NVV
Sbjct: 19  MGIGINGNLPWRLRQEMAYFERLTKTAQMEGMKNAVIMGRKTWDSIPEKFRPLKDRVNVV 78

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           L+ S +     A++  +C S+          P   +++ V++ GG  ++++ +++P C  
Sbjct: 79  LSNSLTECPPGADH--LCSSLNEAVKLFSSPPLSETVDMVWITGGSAVYKDGIDSPHCHR 136

Query: 196 IHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND------IRYSFATY 240
           I+ T I   IECDTF P  D  +++L   + P V+ D      I+Y F  Y
Sbjct: 137 IYLTRIMKEIECDTFFPEFDLDRFKL--VTDPAVDQDTQEEKGIQYKFEIY 185


>Q6WEA2_HARCA (tr|Q6WEA2) Dihydrofolate reductase OS=Hartmannella cantabrigiensis
           GN=DHFR PE=3 SV=1
          Length = 182

 Score =  123 bits (308), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 68/182 (37%), Positives = 100/182 (54%), Gaps = 7/182 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
           + +VVA TK MGIG  G LPW  +  D+ FFK+IT+ T D  K+NA+ MGRKT+  IP K
Sbjct: 4   FALVVAVTKTMGIGNKGGLPWSSIRGDMNFFKKITSETKDAAKQNAVTMGRKTYVGIPAK 63

Query: 125 YRPLPGRLNVVLTRSGSF--DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           +RPL  R+N+V++ + +   +    ++V I  S           P   +IE VFVIGG  
Sbjct: 64  FRPLSNRVNIVISTNANLRKEESIPDSVHIVDSFELAVTKAYSLP---NIENVFVIGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHA-SIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYV 241
           ++ E +  P C+ I +T I      CDTF P ++   +++   S  + E +  Y F TY 
Sbjct: 121 VYAEAMKHPQCKTIFYTNILTPDFTCDTFFPKIEENVFKVTSRSDLQQEGETSYEFLTYS 180

Query: 242 RV 243
            V
Sbjct: 181 GV 182


>B0X4N3_CULQU (tr|B0X4N3) Dihydrofolate reductase OS=Culex quinquefasciatus
           GN=CpipJ_CPIJ014417 PE=3 SV=1
          Length = 182

 Score =  122 bits (307), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 65/182 (35%), Positives = 102/182 (56%), Gaps = 12/182 (6%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           + + ++VA   + GIG  G LPWRL ++L+ F  +T   +DPGK+NAI+MGRKT+  IP 
Sbjct: 2   KKFSLIVAVCSNGGIGIKGDLPWRLRSELRHFARMTKRVADPGKRNAIIMGRKTYFGIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPLP RLNVVLTR  + +    E V++C S+               +E +++IGG  +
Sbjct: 62  GRRPLPDRLNVVLTRDPASNT-YPEGVLVCTSLEDALAKIQDL-----VENIWIIGGSAV 115

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP-----KVENDIRYSFA 238
           ++E + +  C  I+ TEI A  ECD F P +   +++L  +        + EN +R+ + 
Sbjct: 116 YKEAMESRHCHRIYLTEILAPFECDAFFPEI-GKEFRLVGNDADLAEEVQEENGVRFQYK 174

Query: 239 TY 240
            Y
Sbjct: 175 IY 176


>Q8MQV3_LEIIN (tr|Q8MQV3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Leishmania infantum GN=DHFR-TS PE=3 SV=1
          Length = 520

 Score =  122 bits (307), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 86/282 (30%), Positives = 127/282 (45%), Gaps = 55/282 (19%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTW 118
           R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VMGRKTW
Sbjct: 25  RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRKTW 84

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFDIGTA------------ENVVICGSIXXXXXXXXXX 166
           ES+P+K+RPL GRLN+VL+   + +   A            + VV+ G +          
Sbjct: 85  ESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNGGLAEALRLLARP 144

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDSTKYQLW 222
           PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P          
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 194

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
              FP       +  A+    + S A               D L+FE+  +      + +
Sbjct: 195 ---FPPENTTTAWDLASSQGRRKSEA---------------DGLEFEICKY------VPR 230

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            HEE  YL LI  I+              +S FG QMRF+LR
Sbjct: 231 NHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLR 272


>Q8MQV1_LEICH (tr|Q8MQV1) Dhfr-ts OS=Leishmania chagasi PE=3 SV=1
          Length = 520

 Score =  122 bits (307), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 86/282 (30%), Positives = 127/282 (45%), Gaps = 55/282 (19%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTW 118
           R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VMGRKTW
Sbjct: 25  RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRKTW 84

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFDIGTA------------ENVVICGSIXXXXXXXXXX 166
           ES+P+K+RPL GRLN+VL+   + +   A            + VV+ G +          
Sbjct: 85  ESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNGGLAEALRLLARP 144

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDSTKYQLW 222
           PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P          
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 194

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
              FP       +  A+    + S A               D L+FE+  +      + +
Sbjct: 195 ---FPPENTTTAWDLASSQGRRKSEA---------------DGLEFEICKY------VPR 230

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            HEE  YL LI  I+              +S FG QMRF+LR
Sbjct: 231 NHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLR 272


>Q7Q0L5_ANOGA (tr|Q7Q0L5) AGAP010278-PA OS=Anopheles gambiae GN=AGAP010278 PE=3
           SV=3
          Length = 187

 Score =  122 bits (307), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 61/187 (32%), Positives = 102/187 (54%), Gaps = 5/187 (2%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           + + +  +VA  ++ GIG +G LPW+L  +LK+F   T   +D  K+NA++MGRKT+  +
Sbjct: 1   MSKKFSCIVAVCENRGIGINGDLPWKLKQELKYFSHTTKKVNDADKRNAVIMGRKTYFGV 60

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P   RPLP RLN+VLTR+ +       +V++CGS+           +   IE ++V+GG 
Sbjct: 61  PESKRPLPERLNIVLTRNAAA-YTFPPDVLVCGSLQEALHKLDSTDHGEHIENIWVVGGN 119

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYS----SFPKVENDIRYSF 237
            +++E + +  C  I+ TEI    +CD F P + ++   +       S  + EN I+Y +
Sbjct: 120 SVYKEAMESDRCHRIYLTEIKKQFDCDAFFPEIPNSFMVIDNDPDTPSGVQEENGIQYVY 179

Query: 238 ATYVRVQ 244
             Y   Q
Sbjct: 180 KIYENKQ 186


>H9HTP5_ATTCE (tr|H9HTP5) Uncharacterized protein OS=Atta cephalotes PE=3 SV=1
          Length = 180

 Score =  121 bits (304), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 63/179 (35%), Positives = 101/179 (56%), Gaps = 8/179 (4%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           +++ AA ++MGIG +G LPWRL  ++ +F  +TT T +  K+N ++MGR+TWE IP KYR
Sbjct: 6   ELIAAACENMGIGVNGNLPWRLKAEMAYFTRMTTNTRNKNKRNVVLMGRRTWECIPEKYR 65

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PL  R+N+VLT S S + G  ++ + C SI               +E+V+VIGG  +++ 
Sbjct: 66  PLKDRINMVLT-SQSLNYG--DDAIACKSILHALDVISEMQN--EVERVWVIGGSSVYKS 120

Query: 187 VLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP---KVENDIRYSFATYVR 242
            + +P    ++ T I    ECDTF P + +    +  S+ P   + E  I + +  Y R
Sbjct: 121 AMESPHFGRLYLTRIKKKFECDTFFPSIPNDLVLIEDSTVPQGIQEEKGIEFVYEVYER 179


>G8Y630_PICSO (tr|G8Y630) Piso0_004662 protein OS=Pichia sorbitophila (strain
           ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 /
           NRRL Y-12695) GN=Piso0_004662 PE=3 SV=1
          Length = 211

 Score =  121 bits (304), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 58/142 (40%), Positives = 90/142 (63%), Gaps = 3/142 (2%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V A   +MGIG  GK+PWRL  ++ +F+++TT T+D    NA++MGRKTW+SIP K+RP
Sbjct: 18  IVAALVPEMGIGLKGKMPWRLKNEMAYFRKVTTTTTDNEAINAVIMGRKTWQSIPEKFRP 77

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LP RLN+VL+RS   + G  + V+ C S+           Y   +EK+F++GGG+++ + 
Sbjct: 78  LPKRLNIVLSRSQHENDGD-DAVLFCTSLEEALSKAKK--YSKPVEKIFIMGGGELYNQA 134

Query: 188 LNAPGCEAIHFTEIHASIECDT 209
            N+     +  TEI A+ E +T
Sbjct: 135 YNSGQVGHLLLTEIRANKEVET 156


>Q98TR9_DANRE (tr|Q98TR9) Dihydrofolate reductase (Fragment) OS=Danio rerio
           GN=dhfr PE=2 SV=1
          Length = 191

 Score =  121 bits (304), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 70/195 (35%), Positives = 106/195 (54%), Gaps = 32/195 (16%)

Query: 69  VVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           +VA   DMGIGK+G LPW   RL  +LK F+++T   SD GKKN ++MGRKTW SIP  +
Sbjct: 9   IVAVCPDMGIGKNGNLPWHPIRLSNELKHFQKMTMTPSDEGKKNVVIMGRKTWFSIPAAH 68

Query: 126 RPLPGRLNVVLTR------SGSF----DIGTAENVVICGSIXXXXXXXXXXPYCLSIEKV 175
           RPL  R+N+VL+R       G+     D  +A +++  G +               +++V
Sbjct: 69  RPLKNRINIVLSRELKTAPEGAHYLASDFSSALHLLDSGELEKL------------VDQV 116

Query: 176 FVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ 229
           ++IGG  +++EV+   G   +  T I    +CDTF+P  D  KY+L    FP V      
Sbjct: 117 WIIGGSSLYKEVMERSGHRRLFVTRILKQFDCDTFIPNFDMDKYKL-LPEFPGVPVGLQE 175

Query: 230 ENDIRYSFATYVRVQ 244
           +N ++Y F  Y  ++
Sbjct: 176 DNGVQYLFEVYESIE 190


>R7Q5X1_CHOCR (tr|R7Q5X1) Bifunctional dihydrofolate reductase (DHFR) and
           thymidylate synthase (TS) OS=Chondrus crispus
           GN=CHC_T00010030001 PE=4 SV=1
          Length = 515

 Score =  121 bits (304), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 87/269 (32%), Positives = 123/269 (45%), Gaps = 42/269 (15%)

Query: 65  TYQVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           T  ++ A +   GIG  G LPW RL +DL+ FK +T          A++MG  T+ES+P 
Sbjct: 44  TSLILAACSPSRGIGLAGALPWPRLPSDLRNFKTLTLGA-------AVLMGAATYESLPE 96

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPLPGRLNVVL+R    ++   ++V+I GS                +E  FVIGG  +
Sbjct: 97  AVRPLPGRLNVVLSRRSRPELLVPDDVLIAGSFDAAEELLKSK----GVENCFVIGGESV 152

Query: 184 FREVLNAPG-CEAIHFTEIHASIECDTFMPPVDSTK---YQLWYSSFPKVENDIRYSFAT 239
           +RE +  P   + +++TEI    + D F P VD  K   + L   S    E+ +RY    
Sbjct: 153 YREAIKIPAWSQRVYYTEIDKEFKADRFFP-VDLAKEPAFSLLSVSGDIEESGVRYRIKE 211

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           YVRV                D+   S             ++   HEE  YL L++ I+  
Sbjct: 212 YVRVSP--------------DDEPSSRA-----------VVCPPHEEEQYLDLVRHILER 246

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                       +S FG QMRF+LR SFP
Sbjct: 247 GVSKGDRTGVGTISVFGAQMRFDLRHSFP 275


>H0XKH0_OTOGA (tr|H0XKH0) Uncharacterized protein OS=Otolemur garnettii PE=3 SV=1
          Length = 187

 Score =  121 bits (303), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 66/186 (35%), Positives = 99/186 (53%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW  L  +  +F+ +T  +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDLPWPPLRNEFNYFQRMTKTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKESPQGAH--FLAKSLDDALKLIEEPELANKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    ECDTF P +D  KY+L  S +P V      E  I+Y 
Sbjct: 121 VYKEAMNQPGHVKLFVTRIMQDFECDTFFPEIDLKKYKL-LSEYPGVLSDVQEEKGIKYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>Q1LWC6_DANRE (tr|Q1LWC6) Novel protein similar to vertebrate dihydrofolate
           reductase (DHFR) OS=Danio rerio GN=DKEY-174I19.3-001
           PE=2 SV=1
          Length = 195

 Score =  120 bits (302), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 64/190 (33%), Positives = 103/190 (54%), Gaps = 9/190 (4%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           +++  +++ AA +DMGIGKDG++PW L  + +F  +  TA S PGKKN IV GR  W S 
Sbjct: 9   MRKPIRLIAAACRDMGIGKDGQIPWCLPKEFQFLLDTITAVSAPGKKNLIVWGRICWFSC 68

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P    PL   +N+VL+R        A    +C             P C ++E ++++GG 
Sbjct: 69  PETVFPLANCINLVLSRKMISVPPHAH--YLCKDFDSIIRLVSEPPLCHTVEVIWILGGT 126

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRY 235
           ++++E L  P C+ I+ T+I A+ ECD F P  D   ++    SFP V      EN I++
Sbjct: 127 EVYKESLEHPWCDLIYLTDIMANFECDVFFPEFDPNIFRK-QKSFPGVPDEIIEENGIKF 185

Query: 236 SFATYVRVQS 245
            F  + ++++
Sbjct: 186 QFQVFKKIKN 195


>G3MHL1_9ACAR (tr|G3MHL1) Putative uncharacterized protein (Fragment)
           OS=Amblyomma maculatum PE=2 SV=1
          Length = 234

 Score =  120 bits (302), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 100/181 (55%), Gaps = 8/181 (4%)

Query: 69  VVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPL 128
           + A  ++ GIG    LPWRL  ++ FFK +T+  ++ GK+NA+VMGR TWESIP K+RPL
Sbjct: 58  IAAMCRNRGIGFKNALPWRLKKEMAFFKRMTSEAAE-GKQNAVVMGRNTWESIPPKFRPL 116

Query: 129 PGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVL 188
             R+NVV++++ +      E   +  S                ++KVF++GG Q++RE L
Sbjct: 117 NNRINVVVSKTLT---EVPEGHHVASSFPAALQLLQTLVDTGKVDKVFLVGGAQLYREAL 173

Query: 189 NAPGCEAIHFTEIHASIECDTFMPPVDSTKY----QLWYSSFPKVENDIRYSFATYVRVQ 244
            +  C  I+ TE+    ECD F P  D++ +    +      P+ E+ + + F  Y RVQ
Sbjct: 174 ESGHCTRIYLTEVDKDFECDVFFPEFDNSVFSPVEEEGVPQEPQQEDGVTFRFRVYERVQ 233

Query: 245 S 245
           +
Sbjct: 234 N 234


>Q582G3_TRYB2 (tr|Q582G3) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Trypanosoma brucei brucei (strain 927/4
           GUTat10.1) GN=Tb927.7.5480 PE=3 SV=1
          Length = 527

 Score =  120 bits (302), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 90/284 (31%), Positives = 129/284 (45%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + VVVA+ +  GIG  G +PW +  D+++F+ +TT          P K+NA+VMGRKT
Sbjct: 27  RPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKT 86

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFD---------IGTAEN----VVICGSIXXXXXXXX 164
           W+S+P K+RPL  RLNVVL+RS + +         I  AE     V + G +        
Sbjct: 87  WDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLV 146

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIH-ASIECDTFMPPVDSTKYQ 220
              +  SIE VF IGGG I+++ L AP     +AIH T +  AS  C  F          
Sbjct: 147 SKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFF--------- 197

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
                      DI  +    +       ES+   TD      +   K++ +      +++
Sbjct: 198 -----------DIPAAGTKTLEGLELVRESI---TDERVSTGAGGKKYQFE------KLV 237

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E             S FG QMRF+LR
Sbjct: 238 PRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLR 281


>C3KIX5_ANOFI (tr|C3KIX5) Dihydrofolate reductase OS=Anoplopoma fimbria GN=DYR
           PE=2 SV=1
          Length = 189

 Score =  120 bits (302), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 66/193 (34%), Positives = 101/193 (52%), Gaps = 13/193 (6%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKTW 118
           + R    +VA   D+GIG++G LPW   RL  + K F+ +T+  S  GK+N ++MGRKTW
Sbjct: 1   MSRVLNAIVAVCPDLGIGRNGDLPWHPVRLNNEFKHFRRMTSTPSVEGKQNVVIMGRKTW 60

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVI 178
            SIP K RPL  R+N+VL+R        A ++                     +++V+VI
Sbjct: 61  FSIPEKNRPLNNRINIVLSRELKTPPAGAHHL---AQDFNSALRLVDMKLAEQVDQVWVI 117

Query: 179 GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------END 232
           GG  +++E++ + G   +  T+I    ECDTF+P +   KY+L    FP V      EN 
Sbjct: 118 GGSSLYKELMESQGIRRLFVTQILKQFECDTFLPKISPDKYRL-LPEFPGVPQELQEENG 176

Query: 233 IRYSFATYVRVQS 245
           I+Y F  Y  ++ 
Sbjct: 177 IQYRFEVYESIEQ 189


>Q8T5T9_TRYCR (tr|Q8T5T9) Dihydrofolate reductase-thymidylate synthase
           OS=Trypanosoma cruzi PE=3 SV=1
          Length = 521

 Score =  120 bits (302), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 140

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 183

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 184 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 225

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 226 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 275


>C9ZTK8_TRYB9 (tr|C9ZTK8) Dihydrofolate reductase-thymidylate synthase
           OS=Trypanosoma brucei gambiense (strain
           MHOM/CI/86/DAL972) GN=TbgDal_VII6360 PE=3 SV=1
          Length = 527

 Score =  120 bits (302), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 90/284 (31%), Positives = 129/284 (45%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + VVVA+ +  GIG  G +PW +  D+++F+ +TT          P K+NA+VMGRKT
Sbjct: 27  RPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKT 86

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFD---------IGTAEN----VVICGSIXXXXXXXX 164
           W+S+P K+RPL  RLNVVL+RS + +         I  AE     V + G +        
Sbjct: 87  WDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLV 146

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIH-ASIECDTFMPPVDSTKYQ 220
              +  SIE VF IGGG I+++ L AP     +AIH T +  AS  C  F          
Sbjct: 147 SKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFF--------- 197

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
                      DI  +    +       ES+   TD      +   K++ +      +++
Sbjct: 198 -----------DIPAAGTKTLEGLELVRESI---TDERVSTGAGGKKYQFE------KLV 237

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E             S FG QMRF+LR
Sbjct: 238 PRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLR 281


>D3JL87_TRYCR (tr|D3JL87) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  120 bits (302), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>I6LEA0_TRYCR (tr|I6LEA0) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (302), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 89/284 (31%), Positives = 127/284 (44%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 220
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F    +S    
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGT-- 189

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
                  +    I +   T    ++SA              N +  K+      +  ++I
Sbjct: 190 -------EAAAGIEWQRETISEERTSA--------------NGNETKY------YFEKLI 222

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 223 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>D3JLB1_TRYCR (tr|D3JLB1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 471

 Score =  120 bits (301), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>D3JLB2_TRYCR (tr|D3JLB2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  120 bits (301), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 5   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 64

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 65  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 124

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 125 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 167

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 168 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 209

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 210 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 259


>Q963S7_9TRYP (tr|Q963S7) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma vespertilionis
           GN=DHFR-TS PE=3 SV=1
          Length = 491

 Score =  120 bits (301), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 92/284 (32%), Positives = 130/284 (45%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFFK++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFKDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLQDEEKRNLYADSIVAVNGGLEQALQLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 220
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F          
Sbjct: 131 SLNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVF---------- 180

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
            ++   P  E       A  +  Q    E++S+    L   N +  K+      +  ++I
Sbjct: 181 -FHVPEPGTEP------AAGIEWQR---ETISEE---LTSANGNETKY------YFEKLI 221

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 222 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>J4TW37_SACK1 (tr|J4TW37) DFR1-like protein OS=Saccharomyces kudriavzevii (strain
           ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC
           2889) GN=YOR236W PE=3 SV=1
          Length = 211

 Score =  120 bits (301), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 70/191 (36%), Positives = 107/191 (56%), Gaps = 28/191 (14%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     DMGIG  G LPWRL  ++KFF+++T++T D  KKNA+VMGRKTWESIP K+RP
Sbjct: 11  IVACLQPDMGIGFQGGLPWRLSKEMKFFRQVTSSTKDANKKNAVVMGRKTWESIPPKFRP 70

Query: 128 LPGRLNVVLTRS--GSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           LP R+NVV++RS    F     E+++   S+           +  S+EK++VIGGG+++ 
Sbjct: 71  LPNRMNVVISRSFKDGFVHDEEESIIKSNSLANALTNLQNK-FQESLEKIYVIGGGEVYN 129

Query: 186 EVLNAPGCEAIHFTEIH-----ASIECDTFMPPVDSTKYQLWYS---------------S 225
           ++   P  +    T+IH     A+   DTF+   D+ + +  +S                
Sbjct: 130 QIF--PITDHWLITKIHSLDNEAAPAMDTFL---DAKRLKEAFSEQDPAQLKEFLPPKVD 184

Query: 226 FPKVENDIRYS 236
            P+ ++D RYS
Sbjct: 185 LPETDSDQRYS 195


>H9AZH4_TRYCR (tr|H9AZH4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 508

 Score =  120 bits (301), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 19  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 78

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 79  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 138

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 139 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 181

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 182 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 223

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 224 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 273


>D3JL83_TRYCR (tr|D3JL83) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 476

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>D6CJT7_9BACT (tr|D6CJT7) Dihydrofolate reductase OS=uncultured bacterium GN=folA
           PE=3 SV=1
          Length = 179

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 60/151 (39%), Positives = 84/151 (55%), Gaps = 6/151 (3%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + V+VA  ++ GIG+  +LPW L  DLK F+E+T    +   +NA++MGRKTWES+P  Y
Sbjct: 7   FTVIVAMDENRGIGRANELPWHLPEDLKHFREVTCQVENRDNQNAVIMGRKTWESLPQAY 66

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPLP R N+VL+R     + +   V+                    IEK+FVIGGGQ+F 
Sbjct: 67  RPLPHRKNIVLSRK---HLNSPPEVMAFSDFDAAIRSLSAMD---RIEKIFVIGGGQVFE 120

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPVDS 216
             +    C+ I  TEI  S +CD F P + S
Sbjct: 121 TAIRHSQCQEILVTEIQDSFKCDVFFPDISS 151


>B0BMV8_RAT (tr|B0BMV8) Dihydrofolate reductase OS=Rattus norvegicus GN=Dhfr
           PE=2 SV=1
          Length = 187

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 67/184 (36%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLF-TDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW L   + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+V+GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKEPPQGAH--FLAKSLDDALKLIEQPELASKVDMVWVVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKL-LPEYPGVLSEIQEEKGIKYK 179

Query: 237 FATY 240
           F  Y
Sbjct: 180 FEVY 183


>Q296C6_DROPS (tr|Q296C6) GA13324 OS=Drosophila pseudoobscura pseudoobscura
           GN=Dpse\GA13324 PE=3 SV=2
          Length = 185

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 64/179 (35%), Positives = 102/179 (56%), Gaps = 11/179 (6%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + ++VA +++ GIG  G LPWRL ++LK+F   T  TSDP K+N ++MGRKT+  +P   
Sbjct: 4   FNLIVAVSENFGIGLKGDLPWRLKSELKYFSRTTKRTSDPNKRNVVIMGRKTYFGVPASK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAE---NVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           RPLP RLN+VL+ +    +  AE   +VV+C S+               IE V+++GG  
Sbjct: 64  RPLPERLNIVLSTT----LKPAELPSDVVLCHSLEEAMKHLEEETLRDQIENVWIVGGSG 119

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPV-DSTKYQLWYSSFP---KVENDIRYSF 237
           ++ E + +  C  ++ T+I  + ECDTF P + DS +     +  P   + EN I+Y +
Sbjct: 120 VYEEAMASSRCNRLYITKIQQNFECDTFFPSIPDSFREVPPDADTPVGVQEENGIKYEY 178


>F1QRU7_DANRE (tr|F1QRU7) Uncharacterized protein OS=Danio rerio GN=zgc:153031
           PE=3 SV=1
          Length = 195

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 64/190 (33%), Positives = 102/190 (53%), Gaps = 9/190 (4%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           +++  +++ AA +DMGIGKDG++PW L  + +F  +  TA S PGKKN IV GR  W S 
Sbjct: 9   MRKPIRLIAAACRDMGIGKDGQIPWCLPKEFQFLLDTITAVSAPGKKNLIVWGRICWFSC 68

Query: 122 PLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGG 181
           P    PL   +N+VL+R        A    +C             P C ++E ++++GG 
Sbjct: 69  PETVFPLANCINLVLSRKMISVPPHAH--YLCKDFDSIIRLVSEPPLCHTVEVIWILGGT 126

Query: 182 QIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRY 235
           ++++E L  P C+ I+ T I A+ ECD F P  D   ++    SFP V      EN I++
Sbjct: 127 EVYKESLEHPWCDLIYLTNIMANFECDVFFPEFDPNIFRK-QKSFPGVPDEIIEENGIKF 185

Query: 236 SFATYVRVQS 245
            F  + ++++
Sbjct: 186 QFQVFKKIKN 195


>Q95NI3_TRYCR (tr|Q95NI3) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>Q8T5T8_TRYCR (tr|Q8T5T8) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Trypanosoma cruzi GN=TCSYLVIO_001858 PE=1
           SV=1
          Length = 521

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 140

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 183

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 184 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 225

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 226 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 275


>D3JLA1_TRYCR (tr|D3JLA1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>D3JL82_TRYCR (tr|D3JL82) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 478

 Score =  120 bits (301), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>I6LEA8_TRYCR (tr|I6LEA8) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (300), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 90/284 (31%), Positives = 129/284 (45%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 220
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F          
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFF--------- 182

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
                 P+   +     A  +  Q    E++S+    L   N +  K+      +  ++I
Sbjct: 183 ----RVPEAGTEA----AAGIEWQR---ETISEE---LTSANGNETKY------YFEKLI 222

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 223 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>Q4DLS1_TRYCC (tr|Q4DLS1) Dihydrofolate reductase-thymidylate synthase, putative
           OS=Trypanosoma cruzi (strain CL Brener)
           GN=Tc00.1047053509153.90 PE=3 SV=1
          Length = 521

 Score =  120 bits (300), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 140

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 183

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 184 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 225

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 226 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 275


>D3JL86_TRYCR (tr|D3JL86) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 476

 Score =  120 bits (300), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>E9B8U9_LEIDB (tr|E9B8U9) Dihydrofolate reductase-thymidylate synthase
           OS=Leishmania donovani (strain BPK282A1) GN=LDBPK_060890
           PE=3 SV=1
          Length = 520

 Score =  120 bits (300), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 85/282 (30%), Positives = 126/282 (44%), Gaps = 55/282 (19%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG-----KKNAIVMGRKTW 118
           R + +VVA  K  GIG    +PWR+  D+ FFK+ TT   +       K+NA+VMGRKTW
Sbjct: 25  RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRKTW 84

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFDIGTA------------ENVVICGSIXXXXXXXXXX 166
           ES+P+K+RPL GRLN+VL+   + +   A            + VV+   +          
Sbjct: 85  ESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNDGLAEALRLLARP 144

Query: 167 PYCLSIEKVFVIGGGQIFREVLNAPGCEA---IHFTEIHASI-ECDTFMPPVDSTKYQLW 222
           PYC SIE  + +GG Q++ + + +P  E    ++ T I+ +   C  F P          
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 194

Query: 223 YSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQ 282
              FP       +  A+    + S A               D L+FE+  +      + +
Sbjct: 195 ---FPPENTTTAWDLASSQGRRKSEA---------------DGLEFEICKY------VPR 230

Query: 283 RHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            HEE  YL LI  I+              +S FG QMRF+LR
Sbjct: 231 NHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLR 272


>Q95NX3_TRYCR (tr|Q95NX3) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>Q0IK63_TRYCR (tr|Q0IK63) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>I6LEA6_TRYCR (tr|I6LEA6) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>I6LEA1_TRYCR (tr|I6LEA1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>H9AZH1_TRYCR (tr|H9AZH1) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 508

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 19  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 78

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 79  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 138

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 139 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 181

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 182 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 223

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 224 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 273


>B3M2T2_DROAN (tr|B3M2T2) GF18503 OS=Drosophila ananassae GN=Dana\GF18503 PE=3
           SV=1
          Length = 183

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 56/151 (37%), Positives = 92/151 (60%), Gaps = 4/151 (2%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R + ++VA ++++GIG  G LPWR+ ++LK+F   T  TSDP K+NA++MGRKT+  +P 
Sbjct: 2   RRFSLIVAVSENLGIGIKGDLPWRIKSELKYFSRTTKRTSDPSKRNAVIMGRKTYFGVPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPLP RLN+VL+ +   +    ++V++C ++               IE V+V+GG  +
Sbjct: 62  SKRPLPNRLNIVLSTTLQPE-DLPKDVMLCPNLEAAMKHLEGDD---QIENVWVVGGSGV 117

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPV 214
           + E +++  C  ++ T IH   ECDTF P +
Sbjct: 118 YAEAMDSNRCHRLYITRIHQKFECDTFFPTI 148


>I6LEA2_TRYCR (tr|I6LEA2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>Q95NT2_TRYCR (tr|Q95NT2) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>Q95NS0_TRYCR (tr|Q95NS0) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>A9VA22_MONBE (tr|A9VA22) Predicted protein OS=Monosiga brevicollis GN=29079 PE=3
           SV=1
          Length = 205

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 61/145 (42%), Positives = 83/145 (57%), Gaps = 3/145 (2%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VVAATK  GIG  G+LPW L  D++ F++ITT T  P   NA++MGRKT+ESIP K+RP
Sbjct: 5   LVVAATKAGGIGHQGQLPWHLKADMQHFRDITTKTEQPAAINAVIMGRKTFESIPDKFRP 64

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GRLNVVL+      +     V++  S+          P    IE  ++IGG  ++ E 
Sbjct: 65  LHGRLNVVLSTQKPATLNYPPGVLVASSLQEAFEFLDISPEV--IETAYIIGGASVYNEA 122

Query: 188 LNAPG-CEAIHFTEIHASIECDTFM 211
           L  P     I  T++H  + CDT M
Sbjct: 123 LAKPEYSHYIFMTKVHKDVLCDTVM 147


>I6LEA3_TRYCR (tr|I6LEA3) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  120 bits (300), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 88/290 (30%), Positives = 127/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>M3X0Q6_FELCA (tr|M3X0Q6) Uncharacterized protein (Fragment) OS=Felis catus
           GN=DHFR PE=3 SV=1
          Length = 188

 Score =  119 bits (299), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 67/184 (36%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW  L  + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 4   RPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIP 63

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+V+GG  
Sbjct: 64  EKNRPLKDRINIVLSRDLKEPPQGAH--FLAKSLDDALELTEQPELAHKVDMVWVVGGSS 121

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 122 VYKEAMNRPGHVRLFVTRIMQEFESDTFFPEIDLEKYKL-LPEYPGVLSDIQEEKSIKYK 180

Query: 237 FATY 240
           F  Y
Sbjct: 181 FEVY 184


>F6GYC9_VITVI (tr|F6GYC9) Putative uncharacterized protein OS=Vitis vinifera
           GN=VIT_18s0075g01010 PE=3 SV=1
          Length = 87

 Score =  119 bits (299), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 57/85 (67%), Positives = 64/85 (75%)

Query: 113 MGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSI 172
           MGRKTWESIPL++ PL  RLNV+LTR  SFDI TAENVVIC S+          PYCLSI
Sbjct: 1   MGRKTWESIPLEHWPLRNRLNVILTRPRSFDIATAENVVICRSMAAALELLATSPYCLSI 60

Query: 173 EKVFVIGGGQIFREVLNAPGCEAIH 197
           EKVFVIG GQI +E L+APG +AIH
Sbjct: 61  EKVFVIGSGQILKEGLDAPGRDAIH 85


>H9K575_APIME (tr|H9K575) Uncharacterized protein OS=Apis mellifera GN=Dhfr PE=3
           SV=1
          Length = 178

 Score =  119 bits (299), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 64/179 (35%), Positives = 100/179 (55%), Gaps = 8/179 (4%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
            ++ A  + MGIG  G LPW+L ++L FF  +TT T +P K+N ++MGR+TWESIP + R
Sbjct: 4   HLIAATCEGMGIGIKGTLPWKLKSELAFFTYMTTNTKNPNKRNVVLMGRRTWESIPKENR 63

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PL  R+N+VLT S S D G   +V++C +I               IE ++V GG  +++E
Sbjct: 64  PLKNRINIVLT-SQSLDYGN--DVIVCKNIPHAFEVIEKIKD--RIENIWVTGGSSVYKE 118

Query: 187 VLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFP---KVENDIRYSFATYVR 242
            + +P    ++ T I    ECDTF P + +        + P   + ENDI++ +  Y +
Sbjct: 119 AMESPNFYRLYLTRIKKYFECDTFFPTIPNDFVLTEDPNIPQGIQEENDIQFVYEVYKK 177


>F6PUB9_HORSE (tr|F6PUB9) Uncharacterized protein OS=Equus caballus
           GN=LOC100073256 PE=3 SV=1
          Length = 187

 Score =  119 bits (299), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW  L  + K+F+ +TTA+S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTASSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINLVLSRELKEPPQGAH--FLAKSLDDALSLLEQPELANKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNKPGHLRLFVTRIMQEFESDTFFPEIDFEKYKL-LPEYPGVLSDIQEEKGIKYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>H0XQ29_OTOGA (tr|H0XQ29) Uncharacterized protein OS=Otolemur garnettii PE=3 SV=1
          Length = 187

 Score =  119 bits (299), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 64/179 (35%), Positives = 97/179 (54%), Gaps = 10/179 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           ++A +++ GIGK+G LPW  L  +  +F+ +TT +S  GK+N ++MGRKTW SIP K RP
Sbjct: 8   IIAVSQNRGIGKNGDLPWPPLRNEFNYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L  R+N+VL+R        A    +  S+               ++ V+++GG  +++E 
Sbjct: 68  LKDRINIVLSRELKESSQGAH--FLAKSLDDALKHIEEPELANKVDMVWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATY 240
           +N PG   +  T I    ECDTF P +D  KY+L  S +P V      E  I+Y F  Y
Sbjct: 126 MNQPGHVKLFVTRIMQDFECDTFFPEIDLKKYKL-LSEYPGVLSDVQEEKGIKYRFEVY 183


>I4DP20_PAPXU (tr|I4DP20) Dihydrofolate reductase (Fragment) OS=Papilio xuthus
           PE=2 SV=1
          Length = 173

 Score =  119 bits (299), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 58/158 (36%), Positives = 87/158 (55%), Gaps = 4/158 (2%)

Query: 65  TYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
           T  ++ AA ++MGIG +G LPW+L  ++ +F  +T    D  K NA++MGR+TW+ IP K
Sbjct: 5   TLNLIAAACENMGIGVNGTLPWKLKKEMAYFTTMTMKVKDESKLNAVIMGRRTWDCIPDK 64

Query: 125 YRPLPGRLNVVLTRS-GSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
           YRPL  R+N+V+TR          E VV+  S+               IE  +VIGG  I
Sbjct: 65  YRPLNDRVNIVMTRHVDEVKTKVPEGVVVVPSLDEAVKYIEGRE---DIESTWVIGGSSI 121

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQL 221
           ++  +    C  I+ TEI  S +CD F P +D+ ++ L
Sbjct: 122 YKAAMEHENCGKIYLTEIQKSFDCDAFFPNIDTQQFHL 159


>D3JL96_TRYCR (tr|D3JL96) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  119 bits (299), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 89/290 (30%), Positives = 129/290 (44%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFDI------------GTAENVV-ICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +                 A+++V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNSHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>G1MB80_AILME (tr|G1MB80) Uncharacterized protein OS=Ailuropoda melanoleuca
           GN=LOC100472337 PE=3 SV=1
          Length = 187

 Score =  119 bits (298), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           RT   + A +++MGIGK+G LPW  L  + KFF+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RTLNCIAAVSQNMGIGKNGDLPWPPLRNEFKFFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINLVLSRDLKEPPQGAH--FLAKSLDDALKLIEQPELANKVDIVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND------IRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V +D      I+Y 
Sbjct: 121 VYKEAMNKPGHLRLFVTRIMQEFESDTFFPEIDLDKYKL-LPEYPGVPSDVQEEKGIKYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>F7A9L9_MONDO (tr|F7A9L9) Uncharacterized protein OS=Monodelphis domestica
           GN=LOC100012354 PE=3 SV=1
          Length = 187

 Score =  119 bits (298), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 66/186 (35%), Positives = 98/186 (52%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLF-TDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    + A +K+MGIGKDG LPW L   + K+F+++TT  S  GK+N ++MG+KTW SIP
Sbjct: 3   RQLNCIAAVSKNMGIGKDGDLPWPLLRNEFKYFQKMTTTPSVEGKQNLVIMGKKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+NVVL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKCRPLKDRINVVLSRELKEPPQGAH--YLASSLDNALNLLELPELADKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG + +  T I    E DTF P +D  KY+     +P V      E  I+Y 
Sbjct: 121 VYKEAMNKPGHQRLFITRILQEFESDTFFPEIDLKKYKQ-LQDYPGVSPDVQEEKGIQYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>G0NUX7_CAEBE (tr|G0NUX7) Putative uncharacterized protein OS=Caenorhabditis
           brenneri GN=CAEBREN_10184 PE=3 SV=1
          Length = 189

 Score =  119 bits (298), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 60/168 (35%), Positives = 92/168 (54%), Gaps = 2/168 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R   ++VA   + GIGK+G+LPWR+  D+++F  +T   SDP K+NA++MGRK WESIP 
Sbjct: 2   RKMNLIVAIDSEGGIGKNGELPWRIKKDMQYFAAVTKKVSDPSKRNAVLMGRKCWESIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPL GRLNVVL+R        +EN++I  S+           +  SIE ++ IGG +I
Sbjct: 62  SRRPLVGRLNVVLSR--QLVEQKSENLIISNSLESALKTLSEPQFVDSIETIWNIGGAEI 119

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEN 231
           +   L     + +H T +  +   D  +  ++  K +   +S    EN
Sbjct: 120 YDLALQGNLIKEVHLTRVFKNFAADVHLKSLNFDKMEKIVTSEISSEN 167


>H8XAD5_CANO9 (tr|H8XAD5) Dfr1 trimethoprim resistant dihydrofolate reductase
           (DHFR)e OS=Candida orthopsilosis (strain 90-125)
           GN=CORT_0G04350 PE=3 SV=1
          Length = 194

 Score =  119 bits (298), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 61/149 (40%), Positives = 94/149 (63%), Gaps = 10/149 (6%)

Query: 68  VVVAATKDM-GIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           ++VAA K + GIG  G LPWRL  ++ +FK +TT TSDP  +NA++MGRKTW+SIP K+R
Sbjct: 8   IIVAALKPLYGIGYQGSLPWRLRKEMAYFKRVTTRTSDPSLRNAVIMGRKTWDSIPSKFR 67

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PLP RLN++L+RS   ++   EN++   S+              +IE+V+VIGG +I+ E
Sbjct: 68  PLPSRLNIILSRSFDNEV-IDENLLHAKSVQDSLQLVKDK----NIERVYVIGGAEIYNE 122

Query: 187 VLNAPGCEAIHFTEIHAS----IECDTFM 211
            + +   + +  TEI  +    ++ DTF+
Sbjct: 123 FIKSGLVDNVLLTEIEHTETEKLDMDTFL 151


>B4GFC1_DROPE (tr|B4GFC1) GL22182 OS=Drosophila persimilis GN=Dper\GL22182 PE=3
           SV=1
          Length = 185

 Score =  119 bits (297), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 57/152 (37%), Positives = 90/152 (59%), Gaps = 7/152 (4%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + ++VA +++ GIG  G LPWRL ++LK+F   T  TSDP K+N ++MGRKT+  +P   
Sbjct: 4   FNLIVAVSENFGIGLKGDLPWRLKSELKYFSRTTKRTSDPNKRNVVIMGRKTYFGVPASK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAE---NVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
           RPLP RLN+VL+ +    +  AE   +VV+C S+               IE V+++GG  
Sbjct: 64  RPLPERLNIVLSTT----LQPAELPSDVVLCPSLEEAMKHLEEETLRDQIENVWIVGGSG 119

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPV 214
           ++ E + +  C  ++ T+I  + ECDTF P +
Sbjct: 120 VYEEAMASSRCNRLYITKIQQNFECDTFFPSI 151


>Q2MH30_CRIGR (tr|Q2MH30) Dihydrofolate reductase OS=Cricetulus griseus GN=DHFR
           PE=3 SV=1
          Length = 187

 Score =  119 bits (297), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 65/184 (35%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLF-TDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW +   + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDLPWPMLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKEPPQGAH--FLAKSLDDALKLIEQPELADKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKL-LPEYPGVLSEVQEEKGIKYK 179

Query: 237 FATY 240
           F  Y
Sbjct: 180 FEVY 183


>G9I0D7_9VIRU (tr|G9I0D7) Dihydrofolate reductase OS=Helicoverpa zea nudivirus 2
           GN=orf111 PE=3 SV=1
          Length = 214

 Score =  119 bits (297), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 93/181 (51%), Gaps = 7/181 (3%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     +MGIG +  LPW L  ++  F + TT  + P K NA++MGR TWESIP ++RP
Sbjct: 40  IVAVCENNMGIGMNNSLPWHLKREMAHFTKTTTTATHPNK-NAVIMGRLTWESIPKRFRP 98

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LPGR+N+VLT     D   A  V                     IE  +VIGG  ++   
Sbjct: 99  LPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRG------DIETAWVIGGASVYAAA 152

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSA 247
           +  P C  IH T I    EC+ F P +D+T+++L   +    E D++YS+  Y +  + A
Sbjct: 153 MTHPNCHQIHLTAIKKYYECNVFFPKIDTTRFELISETPCTREGDVQYSYKVYQQRNTHA 212

Query: 248 A 248
           +
Sbjct: 213 S 213


>R7UK12_9ANNE (tr|R7UK12) Uncharacterized protein OS=Capitella teleta
           GN=CAPTEDRAFT_228287 PE=4 SV=1
          Length = 379

 Score =  119 bits (297), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 72/192 (37%), Positives = 100/192 (52%), Gaps = 21/192 (10%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
            +VVAA  + GIG DG+LPW +  D+ FF++IT+ TSDPGK+N ++MGRKTWESIP K+R
Sbjct: 7   NLVVAACTNKGIGVDGRLPWTIRGDMAFFRKITSETSDPGKQNVVLMGRKTWESIPAKHR 66

Query: 127 PLPGRLNVVLTRS------GSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           PLP R+NVVL+ S      GS  I   E++                     I ++FVIGG
Sbjct: 67  PLPNRINVVLSASLKEAPQGSLLIRNFEDIF---------PLMESSDLKDKINELFVIGG 117

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDS--TKYQ---LWYSSFPK-VENDIR 234
             ++     +     +  T +     CDTF+P +D    KYQ     +    K  EN I 
Sbjct: 118 SSLYTMSFKSSHPVRVFLTTVLQEFHCDTFLPEMDDILNKYQKIEFAHEDIGKRTENGIP 177

Query: 235 YSFATYVRVQSS 246
           Y    Y ++  S
Sbjct: 178 YQIEVYDKLNMS 189


>Q8JKV3_9VIRU (tr|Q8JKV3) Dihydrofolate reductase OS=Heliothis zea virus 1
           GN=orf7 PE=3 SV=1
          Length = 264

 Score =  119 bits (297), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 93/181 (51%), Gaps = 7/181 (3%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     +MGIG +  LPW L  ++  F + TT  + P K NA++MGR TWESIP ++RP
Sbjct: 90  IVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNK-NAVIMGRLTWESIPKRFRP 148

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LPGR+N+VLT     D   A  V                     IE  +VIGG  ++   
Sbjct: 149 LPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRG------DIETAWVIGGASVYAAA 202

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFATYVRVQSSA 247
           +  P C  IH T I    EC+ F P +D+T+++L   +    E D++YS+  Y +  + A
Sbjct: 203 MTHPNCHQIHLTAIKKYYECNVFFPKIDTTRFELISETPCTREGDVQYSYKVYQQRNTHA 262

Query: 248 A 248
           +
Sbjct: 263 S 263


>Q75BZ5_ASHGO (tr|Q75BZ5) ACR124Wp OS=Ashbya gossypii (strain ATCC 10895 / CBS
           109.51 / FGSC 9923 / NRRL Y-1056) GN=ACR124W PE=3 SV=1
          Length = 211

 Score =  118 bits (296), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 58/151 (38%), Positives = 92/151 (60%), Gaps = 9/151 (5%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     + GIG  G+LPWRL  ++K+F++ TTAT DP K+NA+VMGRKTWESIP ++RP
Sbjct: 11  IVACLLPEYGIGYQGQLPWRLAREMKYFRQATTATFDPTKRNAVVMGRKTWESIPARWRP 70

Query: 128 LPGRLNVVLTRSGSFDIGTAEN--VVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           LPGRLNVV++R+ +      EN  V+   S+             L +E+++++GG +I+ 
Sbjct: 71  LPGRLNVVVSRTYTSPWAHDENGHVITSNSLQQCVRQLQEQARALGVERIYIMGGAEIYN 130

Query: 186 EVLNAPGCEAIHFTEIHA-----SIECDTFM 211
           +  +   C+ +  TE+       ++  DTF+
Sbjct: 131 QSYDL--CDHLLVTELQVAPDGPAVLLDTFL 159


>H0H1D7_9SACH (tr|H0H1D7) Dfr1p OS=Saccharomyces cerevisiae x Saccharomyces
           kudriavzevii VIN7 GN=VIN7_10063 PE=3 SV=1
          Length = 193

 Score =  118 bits (296), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 68/183 (37%), Positives = 104/183 (56%), Gaps = 28/183 (15%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIG  G LPWRL  ++KFF+++T++T D  KKNA+VMGRKTWESIP K+RPLP R+NVV
Sbjct: 1   MGIGFQGGLPWRLSKEMKFFRQVTSSTKDANKKNAVVMGRKTWESIPSKFRPLPNRMNVV 60

Query: 136 LTRS--GSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGC 193
           ++RS    F     E+++   S+           +  S+EK++VIGGG+++ ++   P  
Sbjct: 61  ISRSFKDGFVHDEEESIIKSNSLVNALTNLQNK-FQESLEKIYVIGGGEVYNQIF--PIT 117

Query: 194 EAIHFTEIH-----ASIECDTFMPPVDSTKYQLWYS---------------SFPKVENDI 233
           +    T+IH     A+   DTF+   D+ + +  +S                 P+ ++D 
Sbjct: 118 DHWLITKIHSLDNEAAPAMDTFL---DAKRLKETFSEQDPAQLKEFLPPKVDLPETDSDQ 174

Query: 234 RYS 236
           RYS
Sbjct: 175 RYS 177


>L9L4C5_TUPCH (tr|L9L4C5) Dihydrofolate reductase OS=Tupaia chinensis
           GN=TREES_T100019308 PE=3 SV=1
          Length = 187

 Score =  118 bits (296), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 66/186 (35%), Positives = 99/186 (53%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW  L  + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNIVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINLVLSRELKEPPQGAH--FLAKSLNDALKLIEQPELANQVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNQPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>M1VHU6_CYAME (tr|M1VHU6) Fusion protein of dihydrofolate reductase and
           thymidylate synthase OS=Cyanidioschyzon merolae strain
           10D GN=CYME_CMS462C PE=3 SV=1
          Length = 535

 Score =  118 bits (296), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 89/294 (30%), Positives = 127/294 (43%), Gaps = 38/294 (12%)

Query: 59  LPNLQRTYQVVVAA-TKDMGIGKDGKLPW-RLFTDLKFFKEITT----ATSDP----GKK 108
           +PN+Q   ++VVA    D GIG +G+LPW  +  DL  FK +TT    ++ D     G K
Sbjct: 6   IPNVQLPLRIVVAVQAADWGIGYNGQLPWPHIAEDLAHFKRVTTRNCRSSEDESAVVGGK 65

Query: 109 NAIVMGRKTWESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPY 168
            A++MGR TW SIP + RPL GRLN+VLTR     +  A +      +            
Sbjct: 66  PAVIMGRHTWLSIPPERRPLSGRLNIVLTRQKPI-VNEASDAFAGAYLANSLNEACSLAA 124

Query: 169 CLSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIH------ASIECDTFMPPVDSTKY--- 219
                  +VIGG  +FRE L  P C+ I+ T I       A   CD FMP + S +Y   
Sbjct: 125 LHGARVAYVIGGASVFRETLAHPACDRIYLTRIRRLDPQRAPYPCDVFMPAIPSDEYVED 184

Query: 220 -----QLWYSSFPKVENDIRYSFATYVRVQ----SSAAESLSQNTDPLFDNNSDSLKFEV 270
                        +    +   F  Y R +    S + E     +D    +N+ +++  V
Sbjct: 185 GPSNKHCVSVCVDERAEQLEVEFLVYRRQERIPMSHSPERERVASDAKPSSNTKTIERPV 244

Query: 271 QNFDFLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
              +         HEE  YL L++ +I              LS FG  MRF+LR
Sbjct: 245 LECN---------HEEQQYLDLVRSVIGHGYRKADRTGVGTLSLFGAMMRFSLR 289


>E0W1C2_PEDHC (tr|E0W1C2) Dihydrofolate reductase, putative OS=Pediculus humanus
           subsp. corporis GN=Phum_PHUM574420 PE=3 SV=1
          Length = 190

 Score =  118 bits (296), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 68/191 (35%), Positives = 97/191 (50%), Gaps = 10/191 (5%)

Query: 65  TYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
            + ++ A   + GIG  G LPW L  +L++F  +T    +P KKNA++MGRKTW+S+P  
Sbjct: 4   NFNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHN 63

Query: 125 YRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIF 184
           ++PLPGR N VLT + S ++  A   V+C  +           Y   IE  +VIGG +++
Sbjct: 64  WKPLPGRYNFVLT-TQSLNLDGA---VVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVY 119

Query: 185 REVLNAPGCEAIHFTEIHASIECDTFMPPVDSTK--YQLWYSSFPK---VENDIRYSFAT 239
             VL    C   + T I    ECD F    D TK   ++     PK    EN+I Y F  
Sbjct: 120 ESVLKYGLCHRFYLTRIKKEFECDCFF-NYDFTKDFKEVSDDRVPKGVQKENEIEYVFHV 178

Query: 240 YVRVQSSAAES 250
           Y +V  S   S
Sbjct: 179 YEKVNESKDSS 189


>F4X717_ACREC (tr|F4X717) Dihydrofolate reductase OS=Acromyrmex echinatior
           GN=G5I_14307 PE=3 SV=1
          Length = 181

 Score =  118 bits (296), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 59/148 (39%), Positives = 89/148 (60%), Gaps = 5/148 (3%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           +++ AA ++MGIG +G LPWRL T++ +F  +TT T    K+N I+MGR+TWE IP KYR
Sbjct: 6   ELIAAACENMGIGVNGDLPWRLKTEMAYFTRMTTNTMCKNKRNVILMGRRTWECIPEKYR 65

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PL  R+N+VLT S   D G  ++ ++C SI               +E+V+VIGG  +++ 
Sbjct: 66  PLKDRINMVLT-SQLLDYG--DDAIVCKSIPHALDVISGMQN--EVERVWVIGGSNVYKS 120

Query: 187 VLNAPGCEAIHFTEIHASIECDTFMPPV 214
            + +P    ++ T I    ECDTF P +
Sbjct: 121 AMESPHFGRLYLTRIKKKFECDTFFPSI 148


>K2NID0_TRYCR (tr|K2NID0) Bifunctional dihydrofolate reductase-thymidylate
           synthase OS=Trypanosoma cruzi marinkellei GN=MOQ_000668
           PE=3 SV=1
          Length = 521

 Score =  118 bits (295), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 90/284 (31%), Positives = 129/284 (45%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + ++VA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 21  RAFSLIVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 81  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLYADSIVAVNGGLEQALQLLA 140

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 220
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F    +S    
Sbjct: 141 SLNYTSSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFHVPES---- 196

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
               + P          A  +  Q    E++S+    L   N    K+      +  ++I
Sbjct: 197 ---GTEP----------AAGIEWQR---ETISEE---LTSANGSETKY------YFEKLI 231

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 232 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 275


>H9YW18_MACMU (tr|H9YW18) Dihydrofolate reductase OS=Macaca mulatta GN=DHFR PE=2
           SV=1
          Length = 187

 Score =  118 bits (295), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 100/181 (55%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ ++++GG  +++E 
Sbjct: 68  LKGRINLVLSRELKEPPQGAH--FLARSLDDALKLTEQPELANKVDMIWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF+P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFLPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 242 R 242
           +
Sbjct: 185 K 185


>M9N265_ASHGS (tr|M9N265) FACR124Wp OS=Ashbya gossypii FDAG1 GN=FAGOS_FACR124W
           PE=4 SV=1
          Length = 211

 Score =  118 bits (295), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 58/151 (38%), Positives = 92/151 (60%), Gaps = 9/151 (5%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     + GIG  G+LPWRL  ++K+F++ TTAT DP K+NA+VMGRKTWESIP ++RP
Sbjct: 11  IVACLLPEYGIGYQGQLPWRLAREMKYFRQATTATFDPTKRNAVVMGRKTWESIPARWRP 70

Query: 128 LPGRLNVVLTRSGSFDIGTAEN--VVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           LPGRLNVV++R+ +      EN  V+   S+             L +E+++++GG +I+ 
Sbjct: 71  LPGRLNVVVSRTYTSPWAHDENGHVITSNSLQQCVRQLQEQARALGVERIYIMGGAEIYN 130

Query: 186 EVLNAPGCEAIHFTEIHA-----SIECDTFM 211
           +  +   C+ +  TE+       ++  DTF+
Sbjct: 131 QSYDL--CDHLLVTELQVAPGGPAVLLDTFL 159


>E3LVK9_CAERE (tr|E3LVK9) CRE-DHFR-1 protein OS=Caenorhabditis remanei
           GN=Cre-dhfr-1 PE=3 SV=1
          Length = 186

 Score =  118 bits (295), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 58/168 (34%), Positives = 90/168 (53%), Gaps = 2/168 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R   ++VA   + GIGK+G LPWR+  D+++F  +T   +DP K+NA++MGRK WESIP 
Sbjct: 2   RRMNLIVAMDSEGGIGKNGTLPWRIKKDMQYFASVTKQVTDPSKRNAVLMGRKCWESIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPL GRLN+VL+R         +N++   S+          P+  +IE ++ IGG +I
Sbjct: 62  SRRPLAGRLNIVLSR--QLPEQKTDNLIFVNSLEAALKLLAEPPFVETIETIWNIGGAEI 119

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEN 231
           +   L     + I+ T +  + E D  +  +D  K +   S     EN
Sbjct: 120 YDLALREKLVDEIYLTRVFKNFEADVHLKSLDINKMEKIISGEVSSEN 167


>Q95NY4_TRYCR (tr|Q95NY4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi marinkellei
           GN=DHFR-TS PE=3 SV=1
          Length = 491

 Score =  118 bits (295), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 90/284 (31%), Positives = 129/284 (45%), Gaps = 52/284 (18%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + ++VA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLIVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLYADSIVAVNGGLEQALQLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHAS-IECDTFMPPVDSTKYQ 220
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS   C  F    +S    
Sbjct: 131 SLNYTSSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFHVPES---- 186

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMI 280
               + P          A  +  Q    E++S+    L   N    K+      +  ++I
Sbjct: 187 ---GTEP----------AAGIEWQR---ETISEE---LTSANGSETKY------YFEKLI 221

Query: 281 LQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
            +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 222 PRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>D3JLA6_TRYCR (tr|D3JLA6) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 477

 Score =  118 bits (295), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 87/290 (30%), Positives = 126/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 4   RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 64  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE  + IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 124 SPNYTPSIETFYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 166

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 167 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 208

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 209 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 258


>I6LE99_TRYCR (tr|I6LE99) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  118 bits (295), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 87/290 (30%), Positives = 126/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  I  E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRITREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>A7TKP4_VANPO (tr|A7TKP4) Putative uncharacterized protein OS=Vanderwaltozyma
           polyspora (strain ATCC 22028 / DSM 70294)
           GN=Kpol_1072p26 PE=3 SV=1
          Length = 221

 Score =  117 bits (294), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 63/154 (40%), Positives = 95/154 (61%), Gaps = 8/154 (5%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     + GIG  G LPWRL  ++KFF+++T++T D GK+NA++MGRKTWESIP K+RP
Sbjct: 9   IVACLLPEFGIGLQGTLPWRLAKEMKFFRQVTSSTFDSGKQNAVIMGRKTWESIPAKFRP 68

Query: 128 LPGRLNVVLTRSGSFDIGTAEN--VVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           LP R NVV++RS + D+  +++   + C S+           Y   IE+V++IGGG+I++
Sbjct: 69  LPNRTNVVISRSFTADLVLSDDNSYLKCNSLYDSIEKLNSS-YKDKIERVYIIGGGEIYK 127

Query: 186 EVLNAPGCEAIHFTEI---HASIECDTFMPPVDS 216
           E LN   C+    T+I       + D   P VD+
Sbjct: 128 ESLNL--CDYWLITKIVPLETGSDDDVPPPKVDT 159


>G1QES9_MYOLU (tr|G1QES9) Uncharacterized protein OS=Myotis lucifugus PE=3 SV=1
          Length = 187

 Score =  117 bits (294), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 65/186 (34%), Positives = 99/186 (53%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           RT   + A +++MGIGK+G LPW  L  + K+F+ +TT +S   KKN ++MGRKTW SIP
Sbjct: 3   RTLNCIAAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSAKDKKNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  KKNRPLKDRINLVLSRELKEPPKGAH--FLAKSLDDALKLIEEPELTNQVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E ++ PG + +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMSKPGHQRLFVTRIMQEFESDTFFPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>E3TFQ6_ICTPU (tr|E3TFQ6) Dihydrofolate reductase OS=Ictalurus punctatus GN=DYR
           PE=2 SV=1
          Length = 192

 Score =  117 bits (294), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 67/193 (34%), Positives = 98/193 (50%), Gaps = 3/193 (1%)

Query: 58  PLPNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKT 117
           P   +Q+  ++V AA ++MGIGKDG+LPW L T+ +FF    TA    GKKN I+ G+ +
Sbjct: 3   PRNEVQKPIRLVAAACRNMGIGKDGRLPWNLPTEFQFFLNTITAVCKSGKKNLIIWGKYS 62

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFV 177
           W S P    PL   L+VVL++        A  V  C             P    IE +++
Sbjct: 63  WFSCPESVFPLANSLHVVLSKKLMSVPKRAHYV--CEDFVSAVKLASHPPLNDLIETIWI 120

Query: 178 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSF 237
           +GG Q+++E L  P C+ I+ T+I A  +C+ F P  D   Y+   + FP V N+I+   
Sbjct: 121 LGGTQVYKEALEHPWCDLIYLTDIMADFDCNVFFPSFDQKFYRK-QNKFPGVPNEIQEEN 179

Query: 238 ATYVRVQSSAAES 250
               R Q    ES
Sbjct: 180 GIKFRFQVFMKES 192


>H0Z9R7_TAEGU (tr|H0Z9R7) Uncharacterized protein OS=Taeniopygia guttata PE=3
           SV=1
          Length = 190

 Score =  117 bits (293), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 10/186 (5%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           + R+   +VA +++MGIGKDG+LPW  L  D K+F+ +T+A+   GKKNA++MGRKTW S
Sbjct: 1   MPRSLNSIVAISQNMGIGKDGRLPWPPLRNDYKYFQRMTSASPVEGKKNAVIMGRKTWFS 60

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP K RPL  R+N+VL+R        A    +  S+               +  V+++GG
Sbjct: 61  IPEKNRPLKDRINIVLSRELKEAPKGAH--YLSKSLDDALALLDSPELQSKVCMVWIVGG 118

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIR 234
             +++E +  P    +  T I    E DTF P +D   Y+L  + +P V      EN I+
Sbjct: 119 SSVYKEAMEKPIHHRLFVTRILKEFESDTFFPEIDHKDYKL-LTEYPGVPADIQEENGIQ 177

Query: 235 YSFATY 240
           Y F  Y
Sbjct: 178 YKFEVY 183


>Q544T5_MOUSE (tr|Q544T5) Dihydrofolate reductase OS=Mus musculus GN=Dhfr PE=2
           SV=1
          Length = 187

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 66/184 (35%), Positives = 98/184 (53%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW  L  + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKEPPRGAH--FLAKSLDDALRLIEQPELASKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKL-LPEYPGVLSEVQEEKGIKYK 179

Query: 237 FATY 240
           F  Y
Sbjct: 180 FEVY 183


>G7MZ91_MACMU (tr|G7MZ91) Putative uncharacterized protein OS=Macaca mulatta
           GN=EGK_18909 PE=3 SV=1
          Length = 187

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 63/186 (33%), Positives = 101/186 (54%), Gaps = 10/186 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R+   +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW  IP
Sbjct: 3   RSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFFIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL GR+N+VL+R        A    +  S+               ++ ++++GG  
Sbjct: 63  EKNRPLKGRINLVLSRELKEPPQGAH--FLARSLDDALKLTEQPELANKVDMIWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF+P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNHPGHLKLFVTRIMQDFESDTFLPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYK 179

Query: 237 FATYVR 242
           F  Y +
Sbjct: 180 FEVYEK 185


>H2QR61_PANTR (tr|H2QR61) Dihydrofolate reductase OS=Pan troglodytes GN=DHFR PE=2
           SV=1
          Length = 187

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 64/181 (35%), Positives = 99/181 (54%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ V+++GG  +++E 
Sbjct: 68  LKGRINLVLSRELKEPPQGAH--FLSRSLDDALKLTEQPELASKVDMVWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 242 R 242
           +
Sbjct: 185 K 185


>Q78EH1_9RODE (tr|Q78EH1) Dihydrofolate reductase OS=Cricetulus sp. PE=2 SV=1
          Length = 187

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 64/184 (34%), Positives = 97/184 (52%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLF-TDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G  PW +   + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDFPWPMLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKEPPQGAH--FLAKSLDNALKLIEQPELADKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKL-LPEYPGVLSEVQEEKGIKYK 179

Query: 237 FATY 240
           F  Y
Sbjct: 180 FEVY 183


>G7P7V4_MACFA (tr|G7P7V4) Putative uncharacterized protein (Fragment) OS=Macaca
           fascicularis GN=EGM_15198 PE=3 SV=1
          Length = 187

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 100/181 (55%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 8   LVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ ++++GG  +++E 
Sbjct: 68  LKGRINLVLSRELKEPPQGAH--FLARSLDDALKRTEQPELANKVDMIWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF+P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFLPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 242 R 242
           +
Sbjct: 185 K 185


>I6LEA5_TRYCR (tr|I6LEA5) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 87/290 (30%), Positives = 126/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SI  V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 266


>Q963S8_TRYCR (tr|Q963S8) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 491

 Score =  117 bits (293), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 87/290 (30%), Positives = 126/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 11  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 70

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 71  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 130

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SI  V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 131 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 173

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 174 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 215

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMRF+LR
Sbjct: 216 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLR 265


>Q78EE3_9RODE (tr|Q78EE3) Dihydrofolate reductase OS=Cricetulus sp. PE=2 SV=1
          Length = 187

 Score =  117 bits (292), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 64/184 (34%), Positives = 97/184 (52%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLF-TDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G  PW +   + K+F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGDFPWPMLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKEPPQGAH--FLAKSLDDALKLIEQPELADKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKL-LPEYPGVLSEVQEEKGIKYK 179

Query: 237 FATY 240
           F  Y
Sbjct: 180 FEVY 183


>C4WVU0_ACYPI (tr|C4WVU0) ACYPI002804 protein OS=Acyrthosiphon pisum
           GN=ACYPI002804 PE=2 SV=1
          Length = 184

 Score =  117 bits (292), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 63/188 (33%), Positives = 105/188 (55%), Gaps = 10/188 (5%)

Query: 60  PNLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWE 119
           P     Y V+ A +K+ GIG  G LPW++  ++++F  +TT  +  G +NA++MGR TW+
Sbjct: 3   PTDDMVYSVIAAVSKNGGIGYKGNLPWKIKKEMEYFNLMTTRVNLKGVQNAVIMGRCTWQ 62

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           SIP KYRPL GR+NVV++++ +      E V++   +               IE ++VIG
Sbjct: 63  SIPDKYRPLKGRINVVISKTLN---SVPEGVLLYPKLEEALKSLYLND---RIENLWVIG 116

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKY-QLWYSSFPK---VENDIRY 235
           G  +++E +N   C+ +  T+I     CDTF P  D+ K+ +   ++ PK    +N I+Y
Sbjct: 117 GSGLYKEAVNDKNCKKLFITKIDQEYLCDTFFPDFDTKKFEETSEANVPKGIQEDNGIKY 176

Query: 236 SFATYVRV 243
            F  + R+
Sbjct: 177 EFKVFKRL 184


>B0YJ76_HUMAN (tr|B0YJ76) Dihydrofolate reductase OS=Homo sapiens GN=DYR PE=2
           SV=1
          Length = 187

 Score =  117 bits (292), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 64/181 (35%), Positives = 99/181 (54%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ V+++GG  +++E 
Sbjct: 68  LKGRINLVLSRELKEPPQGAH--FLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 242 R 242
           +
Sbjct: 185 K 185


>F6SNN4_MACMU (tr|F6SNN4) Uncharacterized protein OS=Macaca mulatta PE=3 SV=1
          Length = 187

 Score =  117 bits (292), Expect = 8e-24,   Method: Compositional matrix adjust.
 Identities = 63/184 (34%), Positives = 100/184 (54%), Gaps = 10/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R+   +VA +++MGI K+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP
Sbjct: 3   RSLNCIVAVSQNMGIRKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL GR+N+VL+R        A    +  S+               ++ ++++GG  
Sbjct: 63  EKNRPLKGRINLVLSRELKEPPQGAH--FLARSLDDALKLTEQPELANKVDMIWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E +N PG   +  T I    E DTF+P +D  KY+L    +P V      E  I+Y 
Sbjct: 121 VYKEAMNHPGHLKLFVTRIMQDFESDTFLPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYK 179

Query: 237 FATY 240
           F  Y
Sbjct: 180 FEVY 183


>H9EWZ9_MACMU (tr|H9EWZ9) Dihydrofolate reductase OS=Macaca mulatta GN=DHFR PE=2
           SV=1
          Length = 187

 Score =  116 bits (291), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 60/167 (35%), Positives = 97/167 (58%), Gaps = 4/167 (2%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MGRKTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ ++++GG  +++E 
Sbjct: 68  LKGRINLVLSRELKEPPQGAH--FLARSLDDALKLTEQPELANKVDMIWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIR 234
           +N PG   +  T I    E DTF+P +D  KY+L    +P V +D++
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFLPEIDLEKYKL-LPEYPGVLSDVQ 171


>D8LBA4_ECTSI (tr|D8LBA4) Putative uncharacterized protein OS=Ectocarpus
           siliculosus GN=Esi_0000_0340 PE=3 SV=1
          Length = 581

 Score =  116 bits (291), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 75/206 (36%), Positives = 111/206 (53%), Gaps = 21/206 (10%)

Query: 60  PNLQRTYQVVVAATK-DMGIGKDGKLPWRLFTDLKFFKE----------ITTATSDPGKK 108
           P+  R++ V+VAAT   +GIGK+G LPWRL  D+ +FK            TTAT+   K 
Sbjct: 10  PSTSRSFVVIVAATAGSLGIGKNGALPWRLAADMAYFKRCTSTPTTSSGTTTATTTTDKI 69

Query: 109 NAIVMGRKTWESIPLKYRPLPGRLNVVLTR--SGSFDIGTAENVVICGSIXXXXXXXXXX 166
           NA++MGRKTW+SIP ++RPL GR NVVL+R  +    +   ++V++ GS+          
Sbjct: 70  NAVIMGRKTWQSIPERFRPLAGRRNVVLSRNPAARDTLRLPKDVLLAGSL--TEALDLLS 127

Query: 167 PYCLS-IEKVFVIGGGQIFREVLNAPGCEAIHFTEIHASI-----ECDTFMPPVDSTKYQ 220
           P   S ++KVFVIGGG ++ E + +  CE +  T +         +CDT  P +D   ++
Sbjct: 128 PAAASEVDKVFVIGGGSVYAEAVASELCEKVLLTSVTPPADGRFDDCDTHFPALDPDTFK 187

Query: 221 LWYSSFPKVENDIRYSFATYVRVQSS 246
           L      + E  +  SF  Y  V  S
Sbjct: 188 LVKKGEAQEEKGVELSFDEYESVNHS 213


>M4A4Q9_XIPMA (tr|M4A4Q9) Uncharacterized protein OS=Xiphophorus maculatus
           GN=DHFR PE=3 SV=1
          Length = 184

 Score =  116 bits (291), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 60/164 (36%), Positives = 90/164 (54%), Gaps = 6/164 (3%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKT 117
           ++ R    +VA   ++GIGKDG LPW   RL  +   F+++T   S  G+KN +VMGRKT
Sbjct: 21  SMSRVLNGIVAVCPNLGIGKDGNLPWHPIRLSNEFAHFRKMTATPSIAGRKNVVVMGRKT 80

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFV 177
           W SIP K RPL GR+N+VL+R        A  +    S                 ++V+V
Sbjct: 81  WFSIPEKNRPLKGRINIVLSREYKVPPAGAHYL---ASDFSSALTLVDTELAEQADQVWV 137

Query: 178 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQL 221
           IGG  +++E++ +PG   +  T++    +CDTF+P +   KYQL
Sbjct: 138 IGGSSLYKELMESPGTRRLFVTQVLQQFDCDTFLPEIVPEKYQL 181


>H2W5E7_CAEJA (tr|H2W5E7) Uncharacterized protein OS=Caenorhabditis japonica
           GN=WBGene00129639 PE=3 SV=2
          Length = 183

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 55/148 (37%), Positives = 86/148 (58%), Gaps = 2/148 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R   ++VA   D GIGK+G LPW +  D+++F + T    +P K+NA++MGRK WESIP 
Sbjct: 2   RKMSLIVAMDADGGIGKNGTLPWSIKKDMQYFVKTTKKVENPEKRNAVLMGRKCWESIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPL GRLN+VL+R  +     + +++I  S           P+  SIE ++ IGG +I
Sbjct: 62  SRRPLAGRLNIVLSRQLAEQ--KSNDLIITNSFESALKMLAEPPFVDSIETIWNIGGAEI 119

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFM 211
           ++  +N    + IH T+I+ S + D  +
Sbjct: 120 YQLAINEKLVDEIHITKIYKSFDADVHL 147


>E3QCI8_COLGM (tr|E3QCI8) Dihydrofolate reductase OS=Colletotrichum graminicola
           (strain M1.001 / M2 / FGSC 10212) GN=GLRG_03720 PE=3
           SV=1
          Length = 213

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 63/157 (40%), Positives = 90/157 (57%), Gaps = 12/157 (7%)

Query: 68  VVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITT---ATSDPGKKNAIVMGRKTWESIPL 123
           ++VAAT++MGIG  G LPW  L  ++ +F  +T    + + P  +NA++MGRKTWESIP 
Sbjct: 7   LIVAATRNMGIGAKGGLPWAGLKKEMAYFARVTKRLPSQAPPNARNAVIMGRKTWESIPP 66

Query: 124 KYRPLPGRLNVVLTRSG-SFDIGTA-------ENVVICGSIXXXXXXXXXXPYCLSIEKV 175
           K+RPL GRLN+V++RS  ++D  +A       E  V  GS+               + +V
Sbjct: 67  KFRPLKGRLNIVISRSHPAWDPASAPATPDADEEPVKVGSLEQALAYLRADGVASRLGRV 126

Query: 176 FVIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMP 212
           FVIGG QI+   L AP    +  T++ A  ECD F P
Sbjct: 127 FVIGGAQIYDATLRAPEARRVLLTKVLAEFECDAFFP 163


>K7HWT8_CAEJA (tr|K7HWT8) Uncharacterized protein OS=Caenorhabditis japonica
           GN=WBGene00211751 PE=3 SV=1
          Length = 183

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 55/148 (37%), Positives = 86/148 (58%), Gaps = 2/148 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R   ++VA   D GIGK+G LPW +  D+++F + T    +P K+NA++MGRK WESIP 
Sbjct: 2   RKMSLIVAMDADGGIGKNGTLPWSIKKDMQYFVKTTKKVENPEKRNAVLMGRKCWESIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPL GRLN+VL+R  +     + +++I  S           P+  SIE ++ IGG +I
Sbjct: 62  SRRPLAGRLNIVLSRQLAEQ--KSNDLIITNSFESALKMLSEPPFVDSIETIWNIGGAEI 119

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFM 211
           ++  +N    + IH T+I+ S + D  +
Sbjct: 120 YQLAINEKLVDEIHITKIYKSFDADVHL 147


>G3RQF8_GORGO (tr|G3RQF8) Uncharacterized protein OS=Gorilla gorilla gorilla
           GN=DHFR PE=3 SV=1
          Length = 187

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 64/181 (35%), Positives = 99/181 (54%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGVLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ V+++GG  +++E 
Sbjct: 68  LKGRINLVLSRELKEPPQGAH--FLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 242 R 242
           +
Sbjct: 185 K 185


>F7IFS4_CALJA (tr|F7IFS4) Uncharacterized protein OS=Callithrix jacchus
           GN=LOC100407633 PE=3 SV=1
          Length = 186

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 62/181 (34%), Positives = 100/181 (55%), Gaps = 11/181 (6%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G+LPW  L  + ++F+ +TT +S   K+N ++MGRKTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGELPWPPLRNEFRYFQRMTTTSSVEDKQNLVIMGRKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L  R+NVVL+R         +  ++  S+               ++ +++IGG  +++E 
Sbjct: 68  LKDRINVVLSRELK---EPPQGALLARSLDDALKLTEQPELANKVDMIWIIGGSSVYKEA 124

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND------IRYSFATYV 241
           ++ PG   +  T I    E DTF P +D  KY+L    +P V +D      I+Y F  Y 
Sbjct: 125 MDHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPQYPGVPSDDQEEKGIKYKFEVYE 183

Query: 242 R 242
           +
Sbjct: 184 K 184


>B5U9U8_BABGI (tr|B5U9U8) Dihydrofolate reductase-thymidylate synthase OS=Babesia
           gibsoni GN=Bgdhfr-ts PE=2 SV=1
          Length = 515

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 80/269 (29%), Positives = 132/269 (49%), Gaps = 17/269 (6%)

Query: 67  QVVVAATKDMGIGKDGKLPW-RLFTDLKFFKEITT------ATSDPGKKNAIVMGRKTWE 119
           Q++VA   +  IGK+ ++PW  +  D +F   +TT         +P  KN ++ GRKT+E
Sbjct: 11  QIIVATALNRVIGKNNEIPWPHIRQDFRFLYWVTTFIEPEVKAKNPELKNVVIFGRKTYE 70

Query: 120 SIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIG 179
           SIP    PL GR+NV+++RS    I     V+   S+             +   K+F++G
Sbjct: 71  SIPQNVLPLKGRINVLISRS----IKEMPGVLTFSSLDAAIKELRA---SVPHNKIFILG 123

Query: 180 GGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVENDIRYSFAT 239
           G +I+R VL    C+ I+ T I+   E D F P +  T +++   S     + + Y F T
Sbjct: 124 GSEIYRLVLENDLCDKIYQTRINKDYEGDRFFPEIPDT-FEITGISKTFGTDFVTYDFVT 182

Query: 240 YVRVQSSAAESLSQNTDPLFDNNSDSLKFEVQNFDFLPEMILQRHEEYMYLRLIQEIISE 299
           Y + +S   +    + D L     +  K +V  +   P + ++ HEE+ YL ++ +++S 
Sbjct: 183 YEK-KSVVKDKPHPSMDELVLTGEEP-KVKVPQYVACPSVKIRYHEEFQYLDILADVLSN 240

Query: 300 XXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
                        SKFG QMRF+L +SFP
Sbjct: 241 GTLKQNRTGTDAYSKFGYQMRFDLSKSFP 269


>I6LEA7_TRYCR (tr|I6LEA7) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 87/290 (30%), Positives = 126/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SIE V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTIIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS F  QMRF+LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFDAQMRFSLR 266


>B4PQL2_DROYA (tr|B4PQL2) GE24403 OS=Drosophila yakuba GN=Dyak\GE24403 PE=3 SV=1
          Length = 181

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 60/177 (33%), Positives = 101/177 (57%), Gaps = 8/177 (4%)

Query: 65  TYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLK 124
           ++ ++VA  ++ GIG +G LPWR+ ++LK+F   T  TSDP K NA+VMGRKT+  +P  
Sbjct: 3   SFNLIVAVCENFGIGINGNLPWRIRSELKYFSRTTKRTSDPSKHNAVVMGRKTYFGVPEG 62

Query: 125 YRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIF 184
            RPLP RLN+VL+ +   +    + V++C ++               +E ++++GG  ++
Sbjct: 63  KRPLPDRLNIVLSTTLQ-ENELPKGVLLCRNLEAAMKALEDKN---EVENIWIVGGSGVY 118

Query: 185 REVLNAPGCEAIHFTEIHASIECDTFMPPV-DSTKYQLWYSSFP---KVENDIRYSF 237
            E + +  C  ++ T+IH   ECDTF P + DS +     S  P   + EN I++ +
Sbjct: 119 EEAMASTRCHRLYITKIHEKFECDTFFPAIPDSFREVAPDSDTPLGLQEENGIKFEY 175


>E2BDW3_HARSA (tr|E2BDW3) Dihydrofolate reductase OS=Harpegnathos saltator
           GN=EAI_13642 PE=3 SV=1
          Length = 166

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 55/139 (39%), Positives = 83/139 (59%), Gaps = 5/139 (3%)

Query: 76  MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRLNVV 135
           MGIG  G LPWRL T++++F  +TT T D  KKN ++MGR+TW+ +P  YRPL  R+N+V
Sbjct: 1   MGIGIKGDLPWRLKTEMEYFTRMTTETKDKNKKNVVLMGRRTWDCLPETYRPLRNRINMV 60

Query: 136 LTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPGCEA 195
           LT   S  +   +  ++C SI               +E+V+VIGG ++++E + +P    
Sbjct: 61  LT---SQLMNYGDKAIVCTSIPNALEIITKIQN--EVERVWVIGGSKVYKEAMESPYFGR 115

Query: 196 IHFTEIHASIECDTFMPPV 214
           ++ T I    ECDTF PP+
Sbjct: 116 LYLTRIRKRFECDTFFPPI 134


>F7IE26_CALJA (tr|F7IE26) Uncharacterized protein OS=Callithrix jacchus PE=3 SV=1
          Length = 186

 Score =  116 bits (290), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 62/182 (34%), Positives = 100/182 (54%), Gaps = 11/182 (6%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G+LPW  L  + ++F+ +TT +S   K+N ++MGRKTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGELPWPPLRNEFRYFQRMTTTSSVEDKQNLVIMGRKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L  R+NVVL+R         +  ++  S+               ++ +++IGG  +++E 
Sbjct: 68  LKDRINVVLSRELK---EPPQGALLARSLDDALKLTEQPELANKVDMIWIIGGSSVYKEA 124

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKVEND------IRYSFATYV 241
           ++ PG   +  T I    E DTF P +D  KY+L    +P V +D      I+Y F  Y 
Sbjct: 125 MDHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPQYPGVPSDDQEEKGIKYKFELYT 183

Query: 242 RV 243
            +
Sbjct: 184 TI 185


>B4JFC4_DROGR (tr|B4JFC4) GH19291 OS=Drosophila grimshawi GN=Dgri\GH19291 PE=3
           SV=1
          Length = 184

 Score =  115 bits (289), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 51/149 (34%), Positives = 86/149 (57%), Gaps = 1/149 (0%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + ++VA  ++ GIG  G LPW L ++LK+F   T    DP K+N ++MGR T+  +P   
Sbjct: 4   FNLIVAVCENFGIGFKGNLPWNLKSELKYFSRTTKRVCDPSKRNVVIMGRNTYMGVPPSK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPLP RLN+VL+ + S      + V++C S+           +C  +E V+++GG +++ 
Sbjct: 64  RPLPDRLNIVLSTTMS-AADLPKEVLLCRSLNEAMETIESPEWCKQVENVWIVGGSRVYA 122

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPV 214
           E +++     ++ T+IH   ECDTF P +
Sbjct: 123 EAMDSERFHRLYLTKIHEKFECDTFFPEI 151


>B3P134_DROER (tr|B3P134) GG17010 OS=Drosophila erecta GN=Dere\GG17010 PE=3 SV=1
          Length = 183

 Score =  115 bits (289), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 62/176 (35%), Positives = 99/176 (56%), Gaps = 8/176 (4%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + ++VA  ++ GIG  G LPWR+ ++LK+F  IT  T+DP K NA+VMGRKT+  +P   
Sbjct: 4   FNLIVAVGENFGIGYKGDLPWRIKSELKYFSRITKRTNDPSKHNAVVMGRKTYFGVPESK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPL  RLNVVL+ +   +    E V++C ++               +E V+++GG  +++
Sbjct: 64  RPLSNRLNVVLSTTLQ-ENELPEGVLLCSNLETALKVLENKN---DVENVWIVGGSGVYK 119

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPV-DSTKYQLWYSSFP---KVENDIRYSF 237
           E + +P C  ++ T+I    ECDTF P + DS +     S  P   + EN I + +
Sbjct: 120 EAMASPRCHRLYITKILHKFECDTFFPAIPDSFREVAPDSDIPLGVQEENGIHFEY 175


>B0X1Y0_CULQU (tr|B0X1Y0) Dihydrofolate reductase OS=Culex quinquefasciatus
           GN=CpipJ_CPIJ013529 PE=3 SV=1
          Length = 184

 Score =  115 bits (289), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 57/181 (31%), Positives = 95/181 (52%), Gaps = 5/181 (2%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           +   ++ A  ++ GIG  G LPW L  +LK+F  +T   +D  K+NAI+MGRKT+  +P 
Sbjct: 2   KKLSLIAAVCQNGGIGIKGDLPWHLKAELKYFSRMTKKVNDSAKRNAIIMGRKTYFGVPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPL  RLN+VLTR  + ++  A  V++C S+          P    IE ++++GG  +
Sbjct: 62  AKRPLSERLNIVLTRDPTANVYPA-GVMVCTSMQEALDRLDQSPLVDEIETIWIVGGNAV 120

Query: 184 FREVLNAPGCEAIHFTEIHASIECDTFMPPVDS----TKYQLWYSSFPKVENDIRYSFAT 239
           ++E + +  C  ++ T++  +  CD F P + S     K         + EN I+Y +  
Sbjct: 121 YKEAMESDRCHRLYITDVKGTFNCDAFFPEITSDFKLVKNDADVPEEIQEENGIQYQYKI 180

Query: 240 Y 240
           Y
Sbjct: 181 Y 181


>F7HK25_MACMU (tr|F7HK25) Uncharacterized protein OS=Macaca mulatta GN=DHFR PE=3
           SV=1
          Length = 262

 Score =  115 bits (288), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 100/181 (55%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 83  IVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 142

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L GR+N+VL+R        A    +  S+               ++ ++++GG  +++E 
Sbjct: 143 LKGRINLVLSRELKEPPQGAH--FLARSLDDALKLTEQPELANKVDMIWIVGGSSVYKEA 200

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF+P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 201 MNHPGHLKLFVTRIMQDFESDTFLPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 259

Query: 242 R 242
           +
Sbjct: 260 K 260


>F8UVS0_9BACT (tr|F8UVS0) Dihydrofolate reductase OS=uncultured bacterium PE=3
           SV=1
          Length = 181

 Score =  115 bits (288), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 56/148 (37%), Positives = 87/148 (58%), Gaps = 4/148 (2%)

Query: 67  QVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYR 126
           +++VA  ++  IG +  +PW L  +L++  ++T  T+DP ++NAIVMGR+TWESIP K R
Sbjct: 8   KIIVAYGRNHEIGYENGMPWHLPNELRWVSKVTRHTTDPQRRNAIVMGRRTWESIPAKLR 67

Query: 127 PLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFRE 186
           PL GRLNVV++      + + EN++ C S+           +   IE VF+ GG  I+++
Sbjct: 68  PLKGRLNVVVSHKSPQRLAS-ENLLYCNSLEEALSQLR---HHALIETVFIFGGSTIYKQ 123

Query: 187 VLNAPGCEAIHFTEIHASIECDTFMPPV 214
            L     + IH TE+  S   DTF P +
Sbjct: 124 ALELGVVDEIHATELQESFTADTFFPQI 151


>M3YBC7_MUSPF (tr|M3YBC7) Uncharacterized protein OS=Mustela putorius furo
           GN=Dhfr PE=3 SV=1
          Length = 162

 Score =  115 bits (288), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 60/159 (37%), Positives = 89/159 (55%), Gaps = 3/159 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           RT   + A +++MGIGK+G LPW  L  + KFF+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RTLNCIAAVSQNMGIGKNGDLPWPPLRNEFKFFQRMTTTSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINLVLSRDLKEPPQGAH--FLAKSLDDALKLIEQPELANKVDMVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQL 221
           +++E +N PG   +  T I    E DTF P +D  KY+L
Sbjct: 121 VYKEAMNKPGHLRLFVTRIMQEFESDTFFPEIDLEKYKL 159


>K7HWT7_CAEJA (tr|K7HWT7) Uncharacterized protein OS=Caenorhabditis japonica
           GN=WBGene00211751 PE=3 SV=1
          Length = 257

 Score =  115 bits (288), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 55/145 (37%), Positives = 84/145 (57%), Gaps = 2/145 (1%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPL 123
           R   ++VA   D GIGK+G LPW +  D+++F + T    +P K+NA++MGRK WESIP 
Sbjct: 2   RKMSLIVAMDADGGIGKNGTLPWSIKKDMQYFVKTTKKVENPEKRNAVLMGRKCWESIPE 61

Query: 124 KYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQI 183
             RPL GRLN+VL+R        + +++I  S           P+  SIE ++ IGG +I
Sbjct: 62  SRRPLAGRLNIVLSR--QLAEQKSNDLIITNSFESALKMLSEPPFVDSIETIWNIGGAEI 119

Query: 184 FREVLNAPGCEAIHFTEIHASIECD 208
           ++  +N    + IH T+I+ S + D
Sbjct: 120 YQLAINEKLVDEIHITKIYKSFDAD 144


>Q548M5_PNECA (tr|Q548M5) Dihydrofolate reductase OS=Pneumocystis carinii GN=DHFR
           PE=3 SV=1
          Length = 206

 Score =  115 bits (288), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 58/156 (37%), Positives = 89/156 (57%), Gaps = 4/156 (2%)

Query: 61  NLQRTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT--ATSDPGKK-NAIVMGRKT 117
           N Q++  ++VA T   GIG+   LPW+L  ++ +FK +T+   T D  +  N ++MGRKT
Sbjct: 2   NQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKT 61

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSFDIGTA-ENVVICGSIXXXXXXXXXXPYCLSIEKVF 176
           WESIPL++RPL GR+NVV+TR+ S D+G    +                    + I ++F
Sbjct: 62  WESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIF 121

Query: 177 VIGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMP 212
           VIGG Q+++  ++ P  + I  T I+  I CD F P
Sbjct: 122 VIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFP 157


>R4XAK4_9ASCO (tr|R4XAK4) Dihydrofolate reductase OS=Taphrina deformans PYCC 5710
           GN=TAPDE_001153 PE=4 SV=1
          Length = 440

 Score =  115 bits (287), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 57/155 (36%), Positives = 95/155 (61%), Gaps = 7/155 (4%)

Query: 63  QRTYQVVVAATKD-MGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESI 121
           +R+   +VAAT++ +GIGKDG LPWRL  ++++F ++TTA  + G++N ++MGR +W SI
Sbjct: 221 RRSCTAIVAATENGLGIGKDGGLPWRLKKEMRYFADVTTAAPE-GRQNVVIMGRNSWTSI 279

Query: 122 PLKYRPLPGRLNVVLTRSGSFDI-GTA---ENVVICGSIXXXXXXXXXXPYCLSIEKVFV 177
           P K+RPL GR+N+++T    F++ GTA   ++  +  S+           +     +VF+
Sbjct: 280 PPKFRPLKGRINIIVTSDPGFELTGTAVKSQHNALATSLDDALLQVEKQ-FADVAHRVFI 338

Query: 178 IGGGQIFREVLNAPGCEAIHFTEIHASIECDTFMP 212
           IGG Q++R  L+ P  + I +T I +   CD   P
Sbjct: 339 IGGAQLYRAALSHPALDRILYTAIRSDFACDVHFP 373


>L8I321_BOSMU (tr|L8I321) Dihydrofolate reductase OS=Bos grunniens mutus
           GN=M91_17055 PE=3 SV=1
          Length = 187

 Score =  114 bits (286), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 64/183 (34%), Positives = 97/183 (53%), Gaps = 8/183 (4%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R    +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MGRKTW SIP
Sbjct: 3   RPLNCIVAVSQNMGIGKNGNLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIP 62

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 63  EKNRPLKDRINIVLSRELKEPPKGAH--FLAKSLDDALELIEDPELTNKVDVVWIVGGSS 120

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLW--YSSFP---KVENDIRYSF 237
           +++E +N PG   +  T I    E D F P +D  KY+L   Y   P   + E  I+Y F
Sbjct: 121 VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF 180

Query: 238 ATY 240
             Y
Sbjct: 181 EVY 183


>H2PG01_PONAB (tr|H2PG01) Uncharacterized protein OS=Pongo abelii GN=DHFR PE=3
           SV=1
          Length = 187

 Score =  114 bits (286), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 98/181 (54%), Gaps = 10/181 (5%)

Query: 69  VVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +VA +++MGIGK+G LPW  L  + ++F+ +TT +S  GK+N ++MG+KTW SIP K RP
Sbjct: 8   IVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRP 67

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           L  R+N+VL+R        A    +  S+               ++ V+++GG  +++E 
Sbjct: 68  LKDRINLVLSRELKEPPQGAH--FLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEA 125

Query: 188 LNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYV 241
           +N PG   +  T I    E DTF P +D  KY+L    +P V      E  I+Y F  Y 
Sbjct: 126 MNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKL-LPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 242 R 242
           +
Sbjct: 185 K 185


>J8Q1T3_SACAR (tr|J8Q1T3) Dfr1p OS=Saccharomyces arboricola (strain H-6 / AS
           2.3317 / CBS 10644) GN=SU7_3332 PE=3 SV=1
          Length = 211

 Score =  114 bits (285), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 54/124 (43%), Positives = 81/124 (65%), Gaps = 5/124 (4%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           +V     DMGIG  G LPWRL  ++K+F+++T++T D  KKNA++MGRKTWESIP K+RP
Sbjct: 11  IVACLQPDMGIGFQGGLPWRLPKEMKYFRQVTSSTKDSNKKNAVIMGRKTWESIPPKFRP 70

Query: 128 LPGRLNVVLTRSGSFDIG---TAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIF 184
           LP R+NVV++R  SFD G     E  +I  +            +  S+E+++VIGGG+++
Sbjct: 71  LPNRMNVVISR--SFDDGFDHDKEKSIIRSNSLANALTNLQNKFQDSLERIYVIGGGEVY 128

Query: 185 REVL 188
            ++ 
Sbjct: 129 NQIF 132


>B6AE97_CRYMR (tr|B6AE97) Thymidylate synthase family protein OS=Cryptosporidium
           muris (strain RN66) GN=CMU_010300 PE=3 SV=1
          Length = 549

 Score =  114 bits (285), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 93/296 (31%), Positives = 136/296 (45%), Gaps = 35/296 (11%)

Query: 62  LQRTYQVVVAA-TKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPG----------KKNA 110
           LQ+   ++VAA TK+ GIGK   LPW +  DLKFF+EIT +T +            K NA
Sbjct: 18  LQKPVIIIVAASTKEKGIGKGNNLPWSIKEDLKFFREITCSTIEQSQDDKENTKIEKVNA 77

Query: 111 IVMGRKTWESIPLKYRPLPGRLNVVLTRS-GSFDIGTAENVVICGSIXXXXXXXXXXPYC 169
           I++GRKTW+S  +K  PL  R  +VL+R+    D      V I  S+             
Sbjct: 78  IILGRKTWDS--MKRIPLKNRKVIVLSRTLQRCDNKNDSGVSIVKSLDEAINLCNND--- 132

Query: 170 LSIEKVFVIGGGQIFREVLNAPGCEAIHFTEIHAS-IECDTFMPPVDSTKYQLWYSSFPK 228
           +SI K+ + GG  I+RE +     E I+ T +  S  E DT+ P +  +   +  S    
Sbjct: 133 ISIHKIVICGGESIYRECIEKNIVETIYLTRVSTSKKEFDTYFPNIPESFVPILMSQ-TF 191

Query: 229 VENDIRYSFATY-----------VRVQSSAAESL---SQNTDPLFDNNSDSLKFEVQNFD 274
             NDI Y F  Y           +R  S  +E +       D +F     SL+ +V   D
Sbjct: 192 CCNDISYDFMIYENEILKPIKRNIRNTSCESEVIIPFENVLDKIFGERKISLRNKVPKDD 251

Query: 275 FL--PEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLRRSFP 328
            +  P +I++ H E+ YL ++  ++               S FG  MRF+LR SFP
Sbjct: 252 IISYPSIIIRDHPEFQYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFP 307


>G3BED0_CANTC (tr|G3BED0) Dihydrofolate reductase OS=Candida tenuis (strain ATCC
           10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
           NRRL Y-1498 / VKM Y-70) GN=CANTEDRAFT_116581 PE=3 SV=1
          Length = 188

 Score =  114 bits (285), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 59/146 (40%), Positives = 89/146 (60%), Gaps = 8/146 (5%)

Query: 68  VVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRP 127
           VV A   ++GIG  GKLPWRL  ++  FK IT   +D  K+NA++MGRKTWESIP K++P
Sbjct: 7   VVAALMPNLGIGYKGKLPWRLSKEIINFKNITCKAAD-NKRNAVIMGRKTWESIPKKFKP 65

Query: 128 LPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREV 187
           LP RLN+VLTR+ + +    ++++                   SI+KVF+IGG +++  +
Sbjct: 66  LPDRLNIVLTRTITEEHTNTDDLIYLNDFNKISSVIDD-----SIDKVFLIGGSELYNHL 120

Query: 188 LNAPGCEAIHFTEIHA--SIECDTFM 211
             +   ++I  TE+H   S+E DTF+
Sbjct: 121 FKSNVIDSIILTELHTENSVEIDTFL 146


>L5KJI5_PTEAL (tr|L5KJI5) Dihydrofolate reductase OS=Pteropus alecto
           GN=PAL_GLEAN10024944 PE=3 SV=1
          Length = 186

 Score =  114 bits (285), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 65/184 (35%), Positives = 101/184 (54%), Gaps = 11/184 (5%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWR-LFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIP 122
           R+   +VA +++MGIGK+G LPW  L  + K+F+ +TT +S+ GK+N ++MGRKTW SIP
Sbjct: 3   RSLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSE-GKRNLVIMGRKTWFSIP 61

Query: 123 LKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQ 182
            K RPL  R+N+VL+R        A    +  S+               ++ V+++GG  
Sbjct: 62  KKNRPLKDRINLVLSRELKEPPKGAH--FLAKSLDDALKLIEQPELRSKVDMVWIVGGSS 119

Query: 183 IFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYS 236
           +++E ++ PG   +  T+I    E DTF P +D  KY+L    +P V      E  I+Y 
Sbjct: 120 VYKEAMSKPGHIKLFVTKIMQEFESDTFFPEIDLGKYKL-LPEYPGVLSDVQEEKGIKYK 178

Query: 237 FATY 240
           F  Y
Sbjct: 179 FEVY 182


>I3JW88_ORENI (tr|I3JW88) Uncharacterized protein OS=Oreochromis niloticus
           GN=LOC100695790 PE=3 SV=1
          Length = 189

 Score =  114 bits (285), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 66/192 (34%), Positives = 96/192 (50%), Gaps = 13/192 (6%)

Query: 62  LQRTYQVVVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKTW 118
           + R    +VA   D GIG  G LPW   RL  +   F+++T   S  GK+N ++MG+KTW
Sbjct: 1   MPRVLNAIVAVCPDRGIGNKGNLPWHPIRLSKEFAHFRKMTATPSVKGKQNVVIMGKKTW 60

Query: 119 ESIPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVI 178
            SIP K RPL  R+N+VL+R        A  +    S                 ++V+VI
Sbjct: 61  YSIPEKNRPLSNRINIVLSRECKVPPAGAHYL---ASDFSSALRLIDTELADQADQVWVI 117

Query: 179 GGGQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------END 232
           GG  +++E++ + G   +  T+I    ECDTF+P +   KY+L    FP V      EN 
Sbjct: 118 GGSSLYKEMMGSTGMRRLFVTQILKQFECDTFLPEISLDKYRL-LPEFPDVPQELQEENG 176

Query: 233 IRYSFATYVRVQ 244
           I+Y F  Y  +Q
Sbjct: 177 IQYRFKVYESIQ 188


>M3XI69_LATCH (tr|M3XI69) Uncharacterized protein OS=Latimeria chalumnae PE=3
           SV=1
          Length = 193

 Score =  114 bits (284), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 64/186 (34%), Positives = 97/186 (52%), Gaps = 12/186 (6%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPW---RLFTDLKFFKEITTATSDPGKKNAIVMGRKTWES 120
           R    +VA   ++GIGKDG LPW   RL  + ++F+++TT  +  GK+N ++MGRKTW S
Sbjct: 5   RLLNSIVAVCPNLGIGKDGNLPWHPKRLSNEFRYFQKMTTTPTVEGKQNVVIMGRKTWFS 64

Query: 121 IPLKYRPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGG 180
           IP K RPL GR+NVVL+R        A    +   +               ++ V++IGG
Sbjct: 65  IPEKNRPLKGRVNVVLSRELQEAPEGAH--YLARDLDSALKLLESPELADRVDLVWIIGG 122

Query: 181 GQIFREVLNAPGCEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIR 234
             +++E L  P    +  T +    ECDT++P ++  K+ L    FP V      E+ I+
Sbjct: 123 SALYKEALEHPSQHRLFVTRVLQQFECDTYLPEINFNKFTL-LPEFPGVSSAIQEESGIQ 181

Query: 235 YSFATY 240
           Y F  Y
Sbjct: 182 YKFEVY 187


>I6LEA4_TRYCR (tr|I6LEA4) Bifunctional dihydrofolate reductase-thymidylate
           synthase (Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=3
           SV=1
          Length = 493

 Score =  114 bits (284), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 86/290 (29%), Positives = 125/290 (43%), Gaps = 64/290 (22%)

Query: 64  RTYQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITT------ATSDPGKKNAIVMGRKT 117
           R + +VVA  +  GIG    +PW +  D+KFF+++TT          P K+NA+VMGRKT
Sbjct: 12  RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 71

Query: 118 WESIPLKYRPLPGRLNVVLTRSGSF-------------DIGTAENVVICGSIXXXXXXXX 164
           W+SIP K+RPLPGRLNVVL+ + +              ++     V + G +        
Sbjct: 72  WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 131

Query: 165 XXPYCLSIEKVFVIGGGQIFREVLNAPGC---EAIHFTEIHASIECDTFMPPVDSTKYQL 221
              Y  SI  V+ IGGG ++ E L  P     +AI+ T I AS                 
Sbjct: 132 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS----------------- 174

Query: 222 WYSSFPKVENDIRYSFATYVRVQSSAAESLS-------QNTDPLFDNNSDSLKFEVQNFD 274
                         S + + RV  S  E+ +         ++ L   N +  K+      
Sbjct: 175 ------------ESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKY------ 216

Query: 275 FLPEMILQRHEEYMYLRLIQEIISEXXXXXXXXXXXXLSKFGCQMRFNLR 324
           +  ++I +  EE  YL L+  II E            LS FG QMR +LR
Sbjct: 217 YFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRSSLR 266


>B3RI81_TRIAD (tr|B3RI81) Putative uncharacterized protein OS=Trichoplax
           adhaerens GN=TRIADDRAFT_52382 PE=3 SV=1
          Length = 174

 Score =  114 bits (284), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 61/176 (34%), Positives = 95/176 (53%), Gaps = 10/176 (5%)

Query: 73  TKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKYRPLPGRL 132
           T+D GIG    LPW+L  + K+F  +TT+T D  KKNA++MGR TW SIP K RPL  R+
Sbjct: 2   TRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNRI 61

Query: 133 NVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFREVLNAPG 192
           N+V++     +    E V +  SI               +E V+++GG  +++  ++ P 
Sbjct: 62  NIVISSQLRAE-EVPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYKGFMSHPQ 120

Query: 193 CEAIHFTEIHASIECDTFMPPVDSTKYQLWYSSFPKV------ENDIRYSFATYVR 242
           C+ I+ T++ A+ ECD F P +     ++   S P V      EN ++Y+F  Y R
Sbjct: 121 CDRIYLTKLDANYECDVFFPEMSDDFKEI---SDPDVSQEVQEENGLKYTFHVYQR 173


>G4LU61_DROME (tr|G4LU61) FI15873p1 OS=Drosophila melanogaster GN=Dhfr-RB PE=2
           SV=1
          Length = 182

 Score =  114 bits (284), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 59/176 (33%), Positives = 100/176 (56%), Gaps = 8/176 (4%)

Query: 66  YQVVVAATKDMGIGKDGKLPWRLFTDLKFFKEITTATSDPGKKNAIVMGRKTWESIPLKY 125
           + ++VA  ++ GIG  G LPWR+ ++LK+F   T  TSDP K+NA+VMGRKT+  +P   
Sbjct: 4   FNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTTKRTSDPTKQNAVVMGRKTYFGVPESK 63

Query: 126 RPLPGRLNVVLTRSGSFDIGTAENVVICGSIXXXXXXXXXXPYCLSIEKVFVIGGGQIFR 185
           RPLP RLN+VL+ +   +    + V++C ++               +E ++++GG  ++ 
Sbjct: 64  RPLPDRLNIVLSTTLQ-ESDLPKGVLLCPNLETAMKILEEQN---EVENIWIVGGSGVYE 119

Query: 186 EVLNAPGCEAIHFTEIHASIECDTFMPPV-DSTKYQLWYSSFP---KVENDIRYSF 237
           E + +P C  ++ T+I    +CDTF P + DS +     S  P   + EN I++ +
Sbjct: 120 EAMASPRCHRLYITKIMQKFDCDTFFPAIPDSFREVAPDSDMPLGVQEENGIKFEY 175