Miyakogusa Predicted Gene

Lj0g3v0069809.1
Show Alignment: 

BLASTP 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= Lj0g3v0069809.1 tr|B9H4K8|B9H4K8_POPTR DNA topoisomerase
OS=Populus trichocarpa GN=POPTRDRAFT_861019 PE=3
SV=1,79.24,0,PRTPISMRASEI,DNA topoisomerase, type IA;
TOPOISOMERASE_I_PROK,DNA topoisomerase, type IA, active
sit,CUFF.3360.1
         (452 letters)

Database: trembl 
           41,451,118 sequences; 13,208,986,710 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

K7KV90_SOYBN (tr|K7KV90) DNA topoisomerase OS=Glycine max PE=3 SV=1   752   0.0  
B9H4K8_POPTR (tr|B9H4K8) DNA topoisomerase OS=Populus trichocarp...   703   0.0  
B9SN22_RICCO (tr|B9SN22) DNA topoisomerase (Fragment) OS=Ricinus...   701   0.0  
K7KV93_SOYBN (tr|K7KV93) Uncharacterized protein OS=Glycine max ...   699   0.0  
D7U4C0_VITVI (tr|D7U4C0) Putative uncharacterized protein OS=Vit...   667   0.0  
M0T393_MUSAM (tr|M0T393) DNA topoisomerase OS=Musa acuminata sub...   659   0.0  
Q9LVP1_ARATH (tr|Q9LVP1) DNA topoisomerase OS=Arabidopsis thalia...   655   0.0  
M4ET14_BRARP (tr|M4ET14) DNA topoisomerase OS=Brassica rapa subs...   655   0.0  
R0GNU4_9BRAS (tr|R0GNU4) Uncharacterized protein OS=Capsella rub...   654   0.0  
D7MQJ2_ARALL (tr|D7MQJ2) DNA topoisomerase OS=Arabidopsis lyrata...   651   0.0  
J3LKB1_ORYBR (tr|J3LKB1) DNA topoisomerase OS=Oryza brachyantha ...   646   0.0  
M0WQP1_HORVD (tr|M0WQP1) DNA topoisomerase OS=Hordeum vulgare va...   640   0.0  
M0WQP4_HORVD (tr|M0WQP4) DNA topoisomerase OS=Hordeum vulgare va...   639   0.0  
M0WQP3_HORVD (tr|M0WQP3) DNA topoisomerase OS=Hordeum vulgare va...   639   0.0  
K4A5R4_SETIT (tr|K4A5R4) DNA topoisomerase OS=Setaria italica GN...   637   e-180
C5WWW3_SORBI (tr|C5WWW3) DNA topoisomerase OS=Sorghum bicolor GN...   635   e-179
M0WQP5_HORVD (tr|M0WQP5) DNA topoisomerase OS=Hordeum vulgare va...   634   e-179
C7J0A2_ORYSJ (tr|C7J0A2) DNA topoisomerase OS=Oryza sativa subsp...   632   e-179
I1H9D9_BRADI (tr|I1H9D9) DNA topoisomerase OS=Brachypodium dista...   629   e-178
I1P7W6_ORYGL (tr|I1P7W6) DNA topoisomerase OS=Oryza glaberrima P...   628   e-177
A9U3P7_PHYPA (tr|A9U3P7) DNA topoisomerase OS=Physcomitrella pat...   562   e-157
N1R4S4_AEGTA (tr|N1R4S4) DNA topoisomerase 3-alpha OS=Aegilops t...   556   e-156
B8BDG8_ORYSI (tr|B8BDG8) DNA topoisomerase OS=Oryza sativa subsp...   555   e-155
D8RIM2_SELML (tr|D8RIM2) DNA topoisomerase OS=Selaginella moelle...   534   e-149
Q8S5U5_ORYSJ (tr|Q8S5U5) DNA topoisomerase OS=Oryza sativa subsp...   534   e-149
B9FBH7_ORYSJ (tr|B9FBH7) DNA topoisomerase OS=Oryza sativa subsp...   533   e-149
B8ANX5_ORYSI (tr|B8ANX5) DNA topoisomerase OS=Oryza sativa subsp...   533   e-149
D8SP39_SELML (tr|D8SP39) DNA topoisomerase OS=Selaginella moelle...   521   e-145
M0WQP2_HORVD (tr|M0WQP2) DNA topoisomerase OS=Hordeum vulgare va...   488   e-135
M5WY32_PRUPE (tr|M5WY32) Uncharacterized protein (Fragment) OS=P...   422   e-115
G7JC55_MEDTR (tr|G7JC55) DNA topoisomerase OS=Medicago truncatul...   414   e-113
Q5NCT0_MOUSE (tr|Q5NCT0) DNA topoisomerase 3-alpha OS=Mus muscul...   379   e-102
Q8CDI8_MOUSE (tr|Q8CDI8) DNA topoisomerase (Fragment) OS=Mus mus...   377   e-102
Q5NCT2_MOUSE (tr|Q5NCT2) Topoisomerase (DNA) III alpha OS=Mus mu...   377   e-102
Q3V3P1_MOUSE (tr|Q3V3P1) DNA topoisomerase OS=Mus musculus GN=To...   377   e-102
Q3TBE3_MOUSE (tr|Q3TBE3) DNA topoisomerase OS=Mus musculus GN=To...   376   e-102
L8YCR4_TUPCH (tr|L8YCR4) DNA topoisomerase OS=Tupaia chinensis G...   375   e-101
Q6GPC0_XENLA (tr|Q6GPC0) DNA topoisomerase OS=Xenopus laevis GN=...   374   e-101
R0JZT4_ANAPL (tr|R0JZT4) DNA topoisomerase 3-alpha (Fragment) OS...   373   e-101
M7BIP5_CHEMY (tr|M7BIP5) DNA topoisomerase 3-alpha OS=Chelonia m...   372   e-100
L5KY49_PTEAL (tr|L5KY49) DNA topoisomerase OS=Pteropus alecto GN...   371   e-100
I3MP50_SPETR (tr|I3MP50) DNA topoisomerase OS=Spermophilus tride...   371   e-100
I3JP28_ORENI (tr|I3JP28) DNA topoisomerase (Fragment) OS=Oreochr...   371   e-100
H3AKB8_LATCH (tr|H3AKB8) DNA topoisomerase OS=Latimeria chalumna...   370   e-100
I3JP29_ORENI (tr|I3JP29) DNA topoisomerase OS=Oreochromis niloti...   370   e-100
H9GF12_ANOCA (tr|H9GF12) DNA topoisomerase OS=Anolis carolinensi...   370   e-100
G1SQY7_RABIT (tr|G1SQY7) DNA topoisomerase OS=Oryctolagus cunicu...   370   e-100
G3SN49_LOXAF (tr|G3SN49) DNA topoisomerase OS=Loxodonta africana...   370   e-100
Q4W5X0_CHICK (tr|Q4W5X0) DNA topoisomerase OS=Gallus gallus GN=T...   370   e-100
F1P1F3_CHICK (tr|F1P1F3) DNA topoisomerase OS=Gallus gallus GN=T...   369   1e-99
E2RIS5_CANFA (tr|E2RIS5) DNA topoisomerase OS=Canis familiaris G...   369   1e-99
G3VJM6_SARHA (tr|G3VJM6) DNA topoisomerase OS=Sarcophilus harris...   369   1e-99
F6QP60_MONDO (tr|F6QP60) DNA topoisomerase OS=Monodelphis domest...   369   2e-99
A0JN73_BOVIN (tr|A0JN73) DNA topoisomerase OS=Bos taurus GN=TOP3...   369   2e-99
F1MGY1_BOVIN (tr|F1MGY1) DNA topoisomerase OS=Bos taurus GN=TOP3...   369   2e-99
L8J1J2_BOSMU (tr|L8J1J2) DNA topoisomerase OS=Bos grunniens mutu...   369   2e-99
G5BMX8_HETGA (tr|G5BMX8) DNA topoisomerase OS=Heterocephalus gla...   368   2e-99
K7GGN4_PELSI (tr|K7GGN4) DNA topoisomerase OS=Pelodiscus sinensi...   368   3e-99
K7GGM4_PELSI (tr|K7GGM4) DNA topoisomerase OS=Pelodiscus sinensi...   368   3e-99
M3XLT6_MUSPF (tr|M3XLT6) DNA topoisomerase OS=Mustela putorius f...   367   5e-99
F6YMD1_HORSE (tr|F6YMD1) DNA topoisomerase (Fragment) OS=Equus c...   367   5e-99
F6Z6P9_MACMU (tr|F6Z6P9) DNA topoisomerase OS=Macaca mulatta PE=...   367   7e-99
M3ZNA2_XIPMA (tr|M3ZNA2) DNA topoisomerase OS=Xiphophorus macula...   367   7e-99
H9Z0Q7_MACMU (tr|H9Z0Q7) DNA topoisomerase OS=Macaca mulatta GN=...   367   8e-99
H9EWR7_MACMU (tr|H9EWR7) DNA topoisomerase OS=Macaca mulatta GN=...   366   8e-99
G7PTT8_MACFA (tr|G7PTT8) DNA topoisomerase (Fragment) OS=Macaca ...   366   9e-99
G3GVI0_CRIGR (tr|G3GVI0) DNA topoisomerase OS=Cricetulus griseus...   366   1e-98
G1RUU7_NOMLE (tr|G1RUU7) DNA topoisomerase OS=Nomascus leucogeny...   366   1e-98
G1N063_MELGA (tr|G1N063) DNA topoisomerase OS=Meleagris gallopav...   366   1e-98
F6Z0N0_ORNAN (tr|F6Z0N0) DNA topoisomerase (Fragment) OS=Ornitho...   365   1e-98
G3NY50_GASAC (tr|G3NY50) DNA topoisomerase (Fragment) OS=Gastero...   365   2e-98
G1LDT8_AILME (tr|G1LDT8) DNA topoisomerase OS=Ailuropoda melanol...   365   2e-98
F7A1S4_XENTR (tr|F7A1S4) DNA topoisomerase (Fragment) OS=Xenopus...   365   2e-98
B4DK80_HUMAN (tr|B4DK80) DNA topoisomerase OS=Homo sapiens GN=TO...   365   2e-98
H2R419_PANTR (tr|H2R419) DNA topoisomerase OS=Pan troglodytes GN...   365   2e-98
G3QKQ6_GORGO (tr|G3QKQ6) DNA topoisomerase OS=Gorilla gorilla go...   365   2e-98
K9J3S6_DESRO (tr|K9J3S6) DNA topoisomerase (Fragment) OS=Desmodu...   364   4e-98
G7NJ30_MACMU (tr|G7NJ30) DNA topoisomerase OS=Macaca mulatta GN=...   364   4e-98
K9INH6_DESRO (tr|K9INH6) DNA topoisomerase OS=Desmodus rotundus ...   363   5e-98
H0Z9W6_TAEGU (tr|H0Z9W6) DNA topoisomerase (Fragment) OS=Taeniop...   363   1e-97
H0X7X3_OTOGA (tr|H0X7X3) DNA topoisomerase OS=Otolemur garnettii...   363   1e-97
H0VEI8_CAVPO (tr|H0VEI8) DNA topoisomerase OS=Cavia porcellus GN...   362   2e-97
H2SSS8_TAKRU (tr|H2SSS8) DNA topoisomerase (Fragment) OS=Takifug...   361   4e-97
F1R242_DANRE (tr|F1R242) DNA topoisomerase (Fragment) OS=Danio r...   360   4e-97
H3CL93_TETNG (tr|H3CL93) DNA topoisomerase (Fragment) OS=Tetraod...   360   7e-97
M3WMK3_FELCA (tr|M3WMK3) DNA topoisomerase OS=Felis catus GN=TOP...   358   2e-96
C3Z742_BRAFL (tr|C3Z742) Putative uncharacterized protein (Fragm...   356   8e-96
H2Z239_CIOSA (tr|H2Z239) DNA topoisomerase (Fragment) OS=Ciona s...   354   5e-95
G1NSV2_MYOLU (tr|G1NSV2) DNA topoisomerase OS=Myotis lucifugus P...   353   1e-94
H2Z235_CIOSA (tr|H2Z235) DNA topoisomerase (Fragment) OS=Ciona s...   353   1e-94
H2MFK0_ORYLA (tr|H2MFK0) DNA topoisomerase (Fragment) OS=Oryzias...   353   1e-94
D8TMQ9_VOLCA (tr|D8TMQ9) DNA topoisomerase OS=Volvox carteri GN=...   348   2e-93
E9H1M6_DAPPU (tr|E9H1M6) DNA topoisomerase OS=Daphnia pulex GN=D...   347   5e-93
R7TJU1_9ANNE (tr|R7TJU1) Uncharacterized protein OS=Capitella te...   347   6e-93
I0ZA53_9CHLO (tr|I0ZA53) DNA topoisomerase OS=Coccomyxa subellip...   340   5e-91
H2NSY8_PONAB (tr|H2NSY8) DNA topoisomerase (Fragment) OS=Pongo a...   336   9e-90
G3NY56_GASAC (tr|G3NY56) DNA topoisomerase (Fragment) OS=Gastero...   331   3e-88
H2SSS7_TAKRU (tr|H2SSS7) DNA topoisomerase OS=Takifugu rubripes ...   324   5e-86
Q3TPE4_MOUSE (tr|Q3TPE4) Putative uncharacterized protein OS=Mus...   323   9e-86
M0WQP6_HORVD (tr|M0WQP6) Uncharacterized protein OS=Hordeum vulg...   321   5e-85
H9JC36_BOMMO (tr|H9JC36) DNA topoisomerase OS=Bombyx mori PE=3 SV=1   320   5e-85
J9K335_ACYPI (tr|J9K335) DNA topoisomerase OS=Acyrthosiphon pisu...   320   6e-85
I1FRL5_AMPQE (tr|I1FRL5) DNA topoisomerase OS=Amphimedon queensl...   319   1e-84
Q4SVN5_TETNG (tr|Q4SVN5) DNA topoisomerase (Fragment) OS=Tetraod...   319   1e-84
A7S883_NEMVE (tr|A7S883) Predicted protein (Fragment) OS=Nematos...   316   1e-83
K7IZC3_NASVI (tr|K7IZC3) DNA topoisomerase OS=Nasonia vitripenni...   315   2e-83
H2Z236_CIOSA (tr|H2Z236) DNA topoisomerase (Fragment) OS=Ciona s...   315   2e-83
B4FWE9_MAIZE (tr|B4FWE9) Uncharacterized protein OS=Zea mays PE=...   315   2e-83
K1QMX0_CRAGI (tr|K1QMX0) DNA topoisomerase OS=Crassostrea gigas ...   315   3e-83
B0QZI1_MOUSE (tr|B0QZI1) DNA topoisomerase 3-alpha OS=Mus muscul...   312   2e-82
D4A6J4_RAT (tr|D4A6J4) Protein Top3a OS=Rattus norvegicus GN=Top...   312   2e-82
F2UQ44_SALS5 (tr|F2UQ44) DNA topoisomerase OS=Salpingoeca sp. (s...   304   5e-80
H9HDQ6_ATTCE (tr|H9HDQ6) DNA topoisomerase OS=Atta cephalotes PE...   303   8e-80
F4X1K5_ACREC (tr|F4X1K5) DNA topoisomerase OS=Acromyrmex echinat...   303   8e-80
H9K4U5_APIME (tr|H9K4U5) DNA topoisomerase OS=Apis mellifera GN=...   302   2e-79
G7JC54_MEDTR (tr|G7JC54) DNA topoisomerase OS=Medicago truncatul...   301   5e-79
N6UAY1_9CUCU (tr|N6UAY1) Uncharacterized protein (Fragment) OS=D...   299   1e-78
Q171C3_AEDAE (tr|Q171C3) DNA topoisomerase OS=Aedes aegypti GN=A...   298   3e-78
B0WGC0_CULQU (tr|B0WGC0) DNA topoisomerase OS=Culex quinquefasci...   296   1e-77
B4PAZ8_DROYA (tr|B4PAZ8) DNA topoisomerase OS=Drosophila yakuba ...   293   7e-77
E2A6W4_CAMFO (tr|E2A6W4) DNA topoisomerase OS=Camponotus florida...   293   1e-76
D6WYH2_TRICA (tr|D6WYH2) DNA topoisomerase OS=Tribolium castaneu...   292   2e-76
B4KIW5_DROMO (tr|B4KIW5) DNA topoisomerase OS=Drosophila mojaven...   291   3e-76
B4Q9Z3_DROSI (tr|B4Q9Z3) DNA topoisomerase OS=Drosophila simulan...   291   3e-76
L1K3I3_GUITH (tr|L1K3I3) Uncharacterized protein OS=Guillardia t...   291   4e-76
B4JCW0_DROGR (tr|B4JCW0) DNA topoisomerase OS=Drosophila grimsha...   291   5e-76
B4I5W5_DROSE (tr|B4I5W5) DNA topoisomerase OS=Drosophila sechell...   290   8e-76
K4BYJ2_SOLLC (tr|K4BYJ2) Uncharacterized protein OS=Solanum lyco...   290   1e-75
E2BS26_HARSA (tr|E2BS26) DNA topoisomerase OS=Harpegnathos salta...   289   1e-75
B4M8K0_DROVI (tr|B4M8K0) DNA topoisomerase OS=Drosophila virilis...   288   3e-75
B4GWY2_DROPE (tr|B4GWY2) DNA topoisomerase OS=Drosophila persimi...   288   4e-75
Q29K61_DROPS (tr|Q29K61) DNA topoisomerase OS=Drosophila pseudoo...   286   1e-74
F4PXY0_DICFS (tr|F4PXY0) DNA topoisomerase III OS=Dictyostelium ...   285   2e-74
B4MYR0_DROWI (tr|B4MYR0) DNA topoisomerase OS=Drosophila willist...   285   2e-74
B3MN55_DROAN (tr|B3MN55) DNA topoisomerase OS=Drosophila ananass...   285   2e-74
F7CBA4_CALJA (tr|F7CBA4) DNA topoisomerase OS=Callithrix jacchus...   278   2e-72
D7FUP7_ECTSI (tr|D7FUP7) DNA topoisomerase OS=Ectocarpus silicul...   278   3e-72
E9IAV6_SOLIN (tr|E9IAV6) DNA topoisomerase (Fragment) OS=Solenop...   278   3e-72
F7BHS6_CALJA (tr|F7BHS6) DNA topoisomerase OS=Callithrix jacchus...   277   8e-72
E3WTA7_ANODA (tr|E3WTA7) DNA topoisomerase OS=Anopheles darlingi...   276   9e-72
D3BRX9_POLPA (tr|D3BRX9) Ribose-phosphate pyrophosphokinase OS=P...   274   4e-71
H2Z240_CIOSA (tr|H2Z240) DNA topoisomerase (Fragment) OS=Ciona s...   274   4e-71
E0VPP3_PEDHC (tr|E0VPP3) DNA topoisomerase OS=Pediculus humanus ...   273   1e-70
H2Z237_CIOSA (tr|H2Z237) DNA topoisomerase (Fragment) OS=Ciona s...   271   3e-70
H3J0J4_STRPU (tr|H3J0J4) DNA topoisomerase OS=Strongylocentrotus...   271   4e-70
H2Z238_CIOSA (tr|H2Z238) DNA topoisomerase (Fragment) OS=Ciona s...   270   6e-70
K3WHB4_PYTUL (tr|K3WHB4) Uncharacterized protein OS=Pythium ulti...   270   1e-69
B9PMP6_TOXGO (tr|B9PMP6) DNA topoisomerase OS=Toxoplasma gondii ...   270   1e-69
B6KEM8_TOXGO (tr|B6KEM8) DNA topoisomerase OS=Toxoplasma gondii ...   270   1e-69
H3G7Y5_PHYRM (tr|H3G7Y5) Uncharacterized protein (Fragment) OS=P...   269   2e-69
I1QMB1_ORYGL (tr|I1QMB1) DNA topoisomerase OS=Oryza glaberrima P...   266   1e-68
G4YKY0_PHYSP (tr|G4YKY0) Putative uncharacterized protein OS=Phy...   266   1e-68
F0WXN1_9STRA (tr|F0WXN1) DNA topoisomerase putative OS=Albugo la...   265   2e-68
F0WXN6_9STRA (tr|F0WXN6) DNA topoisomerase putative OS=Albugo la...   265   2e-68
F0WXN7_9STRA (tr|F0WXN7) DNA topoisomerase putative OS=Albugo la...   265   2e-68
F0WXN8_9STRA (tr|F0WXN8) DNA topoisomerase putative OS=Albugo la...   265   2e-68
F0WXP0_9STRA (tr|F0WXP0) DNA topoisomerase putative OS=Albugo la...   265   2e-68
F0WXN4_9STRA (tr|F0WXN4) DNA topoisomerase putative OS=Albugo la...   265   3e-68
H2Z241_CIOSA (tr|H2Z241) DNA topoisomerase (Fragment) OS=Ciona s...   264   6e-68
D2VSX3_NAEGR (tr|D2VSX3) Predicted protein OS=Naegleria gruberi ...   263   8e-68
K0TAA4_THAOC (tr|K0TAA4) Uncharacterized protein (Fragment) OS=T...   263   8e-68
B3RSB2_TRIAD (tr|B3RSB2) Putative uncharacterized protein OS=Tri...   263   9e-68
J9J536_9SPIT (tr|J9J536) DNA topoisomerase OS=Oxytricha trifalla...   263   1e-67
I4YDJ6_WALSC (tr|I4YDJ6) DNA topoisomerase OS=Wallemia sebi (str...   263   2e-67
F4PE38_BATDJ (tr|F4PE38) Putative uncharacterized protein (Fragm...   261   3e-67
L7LY29_9ACAR (tr|L7LY29) DNA topoisomerase OS=Rhipicephalus pulc...   261   3e-67
H2Z243_CIOSA (tr|H2Z243) DNA topoisomerase (Fragment) OS=Ciona s...   260   6e-67
L1LDB1_BABEQ (tr|L1LDB1) DNA topoisomerase OS=Babesia equi GN=BE...   259   1e-66
J9FV51_9SPIT (tr|J9FV51) DNA topoisomerase OS=Oxytricha trifalla...   259   1e-66
E5SGH1_TRISP (tr|E5SGH1) DNA topoisomerase OS=Trichinella spiral...   258   4e-66
B8BZX1_THAPS (tr|B8BZX1) DNA topoisomerase (Fragment) OS=Thalass...   258   5e-66
K9HST2_AGABB (tr|K9HST2) DNA topoisomerase OS=Agaricus bisporus ...   257   9e-66
K5WXT1_AGABU (tr|K5WXT1) DNA topoisomerase OS=Agaricus bisporus ...   256   1e-65
B7G3B1_PHATC (tr|B7G3B1) DNA topoisomerase OS=Phaeodactylum tric...   256   1e-65
Q01CA7_OSTTA (tr|Q01CA7) DNA topoisomerase III alpha, putative (...   256   1e-65
J9J1U5_9SPIT (tr|J9J1U5) DNA topoisomerase OS=Oxytricha trifalla...   255   2e-65
H2Z242_CIOSA (tr|H2Z242) DNA topoisomerase (Fragment) OS=Ciona s...   255   2e-65
F8PV61_SERL3 (tr|F8PV61) DNA topoisomerase OS=Serpula lacrymans ...   255   2e-65
R9AS06_WALIC (tr|R9AS06) DNA topoisomerase 3 OS=Wallemia ichthyo...   255   3e-65
Q55KM2_CRYNB (tr|Q55KM2) DNA topoisomerase OS=Cryptococcus neofo...   255   3e-65
E6R530_CRYGW (tr|E6R530) DNA topoisomerase OS=Cryptococcus gatti...   254   4e-65
E9CIX7_CAPO3 (tr|E9CIX7) DNA topoisomerase OS=Capsaspora owczarz...   254   7e-65
F0ZSL6_DICPU (tr|F0ZSL6) Putative uncharacterized protein OS=Dic...   253   8e-65
G7YVP7_CLOSI (tr|G7YVP7) DNA topoisomerase (Fragment) OS=Clonorc...   253   9e-65
G4VM01_SCHMA (tr|G4VM01) Putative prokaryotic DNA topoisomerase ...   253   9e-65
F0WXN9_9STRA (tr|F0WXN9) DNA topoisomerase putative OS=Albugo la...   253   2e-64
J9W0N6_CRYNH (tr|J9W0N6) DNA topoisomerase OS=Cryptococcus neofo...   253   2e-64
F0WXN5_9STRA (tr|F0WXN5) DNA topoisomerase putative OS=Albugo la...   252   2e-64
F0WXN3_9STRA (tr|F0WXN3) DNA topoisomerase putative OS=Albugo la...   252   2e-64
B6K7U4_SCHJY (tr|B6K7U4) DNA topoisomerase OS=Schizosaccharomyce...   252   2e-64
F0WXN2_9STRA (tr|F0WXN2) DNA topoisomerase putative OS=Albugo la...   252   2e-64
B6A9W0_CRYMR (tr|B6A9W0) DNA topoisomerase OS=Cryptosporidium mu...   252   2e-64
A0CUH3_PARTE (tr|A0CUH3) Chromosome undetermined scaffold_28, wh...   251   3e-64
M7XAM1_RHOTO (tr|M7XAM1) DNA topoisomerase III OS=Rhodosporidium...   251   5e-64
J4CDC9_THEOR (tr|J4CDC9) DNA topoisomerase III OS=Theileria orie...   250   7e-64
M2RFS6_CERSU (tr|M2RFS6) DNA topoisomerase OS=Ceriporiopsis subv...   250   9e-64
Q4PAW5_USTMA (tr|Q4PAW5) DNA topoisomerase OS=Ustilago maydis (s...   249   1e-63
I7LVW6_TETTS (tr|I7LVW6) DNA topoisomerase OS=Tetrahymena thermo...   249   2e-63
M1WBC5_CLAPU (tr|M1WBC5) Related to DNA topoisomerase III OS=Cla...   249   2e-63
C1DZI4_MICSR (tr|C1DZI4) DNA topoisomerase (Fragment) OS=Micromo...   248   3e-63
Q4UB92_THEAN (tr|Q4UB92) DNA topoisomerase iii, putative OS=Thei...   248   3e-63
A9V1D2_MONBE (tr|A9V1D2) DNA topoisomerase OS=Monosiga brevicoll...   248   3e-63
Q7Q111_ANOGA (tr|Q7Q111) DNA topoisomerase OS=Anopheles gambiae ...   248   4e-63
Q6C0R0_YARLI (tr|Q6C0R0) DNA topoisomerase OS=Yarrowia lipolytic...   248   5e-63
A0DEK9_PARTE (tr|A0DEK9) Chromosome undetermined scaffold_48, wh...   247   5e-63
D0NZ98_PHYIT (tr|D0NZ98) DNA topoisomerase, putative OS=Phytopht...   247   6e-63
F1L3P3_ASCSU (tr|F1L3P3) DNA topoisomerase OS=Ascaris suum PE=2 ...   246   1e-62
A0DS57_PARTE (tr|A0DS57) Chromosome undetermined scaffold_61, wh...   245   3e-62
F4RET6_MELLP (tr|F4RET6) Putative uncharacterized protein (Fragm...   245   3e-62
Q5KAU9_CRYNJ (tr|Q5KAU9) DNA topoisomerase OS=Cryptococcus neofo...   244   4e-62
B3L8C2_PLAKH (tr|B3L8C2) DNA topoisomerase III, putative OS=Plas...   244   4e-62
H6BXA1_EXODN (tr|H6BXA1) DNA topoisomerase OS=Exophiala dermatit...   244   4e-62
A5K8A9_PLAVS (tr|A5K8A9) DNA topoisomerase III alpha, putative O...   244   4e-62
K6ULC5_9APIC (tr|K6ULC5) DNA topoisomerase III alpha OS=Plasmodi...   244   5e-62
F9XBA1_MYCGM (tr|F9XBA1) DNA topoisomerase OS=Mycosphaerella gra...   243   9e-62
A7AMD4_BABBO (tr|A7AMD4) DNA topoisomerase family protein OS=Bab...   243   1e-61
G7E0M5_MIXOS (tr|G7E0M5) Uncharacterized protein OS=Mixia osmund...   243   1e-61
I2G1E9_USTH4 (tr|I2G1E9) DNA topoisomerase OS=Ustilago hordei (s...   243   1e-61
C1GBF3_PARBD (tr|C1GBF3) DNA topoisomerase OS=Paracoccidioides b...   243   1e-61
C5GXA3_AJEDR (tr|C5GXA3) DNA topoisomerase OS=Ajellomyces dermat...   243   1e-61
Q8IDM7_PLAF7 (tr|Q8IDM7) DNA topoisomerase III, putative OS=Plas...   243   2e-61
C0S9B3_PARBP (tr|C0S9B3) DNA topoisomerase OS=Paracoccidioides b...   242   2e-61
F2TP38_AJEDA (tr|F2TP38) DNA topoisomerase OS=Ajellomyces dermat...   242   2e-61
C5JDG2_AJEDS (tr|C5JDG2) DNA topoisomerase OS=Ajellomyces dermat...   242   2e-61
A4RUT1_OSTLU (tr|A4RUT1) Predicted protein (Fragment) OS=Ostreoc...   242   2e-61
B4DSJ0_HUMAN (tr|B4DSJ0) DNA topoisomerase 3-alpha OS=Homo sapie...   242   3e-61
E7A0Y6_SPORE (tr|E7A0Y6) DNA topoisomerase OS=Sporisorium reilia...   241   3e-61
G4TIC8_PIRID (tr|G4TIC8) Related to DNA topoisomerase III alpha ...   241   3e-61
M9MAK8_9BASI (tr|M9MAK8) DNA topoisomerase III alpha OS=Pseudozy...   241   5e-61
G0NRK3_CAEBE (tr|G0NRK3) DNA topoisomerase OS=Caenorhabditis bre...   240   7e-61
C1H2W6_PARBA (tr|C1H2W6) DNA topoisomerase OS=Paracoccidioides b...   240   7e-61
B9Q815_TOXGO (tr|B9Q815) DNA topoisomerase OS=Toxoplasma gondii ...   240   1e-60
G6DDL0_DANPL (tr|G6DDL0) DNA topoisomerase OS=Danaus plexippus G...   239   1e-60
K8F3E9_9CHLO (tr|K8F3E9) DNA topoisomerase OS=Bathycoccus prasin...   239   2e-60
Q4MYZ9_THEPA (tr|Q4MYZ9) DNA topoisomerase III, putative OS=Thei...   239   2e-60
K4BYJ3_SOLLC (tr|K4BYJ3) DNA topoisomerase OS=Solanum lycopersic...   238   3e-60
F0XZ97_AURAN (tr|F0XZ97) DNA topoisomerase (Fragment) OS=Aureoco...   238   3e-60
A8XHL1_CAEBR (tr|A8XHL1) DNA topoisomerase OS=Caenorhabditis bri...   238   4e-60
R9NXV4_9BASI (tr|R9NXV4) Uncharacterized protein OS=Pseudozyma h...   238   4e-60
A6R6R2_AJECN (tr|A6R6R2) DNA topoisomerase OS=Ajellomyces capsul...   238   5e-60
B6HC62_PENCW (tr|B6HC62) DNA topoisomerase OS=Penicillium chryso...   237   6e-60
E4YMV5_OIKDI (tr|E4YMV5) DNA topoisomerase OS=Oikopleura dioica ...   237   7e-60
E4YXQ0_OIKDI (tr|E4YXQ0) DNA topoisomerase OS=Oikopleura dioica ...   237   8e-60
Q751B3_ASHGO (tr|Q751B3) DNA topoisomerase OS=Ashbya gossypii (s...   236   1e-59
M9N124_ASHGS (tr|M9N124) FAGL101Cp OS=Ashbya gossypii FDAG1 GN=F...   236   1e-59
Q0CHD1_ASPTN (tr|Q0CHD1) DNA topoisomerase OS=Aspergillus terreu...   236   1e-59
C0NGZ5_AJECG (tr|C0NGZ5) DNA topoisomerase OS=Ajellomyces capsul...   236   1e-59
C6H6Z0_AJECH (tr|C6H6Z0) DNA topoisomerase OS=Ajellomyces capsul...   236   1e-59
B8PK31_POSPM (tr|B8PK31) DNA topoisomerase OS=Postia placenta (s...   236   2e-59
Q2UEI0_ASPOR (tr|Q2UEI0) DNA topoisomerase OS=Aspergillus oryzae...   235   2e-59
I8A9T8_ASPO3 (tr|I8A9T8) DNA topoisomerase OS=Aspergillus oryzae...   235   2e-59
B8NFR2_ASPFN (tr|B8NFR2) DNA topoisomerase OS=Aspergillus flavus...   235   2e-59
E4XGA0_OIKDI (tr|E4XGA0) DNA topoisomerase OS=Oikopleura dioica ...   235   2e-59
A2QNT8_ASPNC (tr|A2QNT8) DNA topoisomerase OS=Aspergillus niger ...   235   3e-59
D5GBK2_TUBMM (tr|D5GBK2) DNA topoisomerase OS=Tuber melanosporum...   235   3e-59
G7XEX1_ASPKW (tr|G7XEX1) DNA topoisomerase OS=Aspergillus kawach...   234   4e-59
C4JSQ6_UNCRE (tr|C4JSQ6) DNA topoisomerase OS=Uncinocarpus reesi...   234   4e-59
E9AT98_LEIMU (tr|E9AT98) DNA topoisomerase OS=Leishmania mexican...   234   5e-59
L2GB63_COLGN (tr|L2GB63) DNA topoisomerase OS=Colletotrichum glo...   234   5e-59
E9DRL7_METAQ (tr|E9DRL7) DNA topoisomerase III OS=Metarhizium ac...   234   6e-59
J4GIB6_FIBRA (tr|J4GIB6) DNA topoisomerase OS=Fibroporia radicul...   234   6e-59
E9NQ03_LEIDO (tr|E9NQ03) DNA topoisomerase OS=Leishmania donovan...   234   7e-59
G3XZ45_ASPNA (tr|G3XZ45) DNA topoisomerase OS=Aspergillus niger ...   234   7e-59
Q7RQG4_PLAYO (tr|Q7RQG4) DNA topoisomerase iii OS=Plasmodium yoe...   234   7e-59
E9F187_METAR (tr|E9F187) DNA topoisomerase III OS=Metarhizium an...   233   8e-59
H2WE23_CAEJA (tr|H2WE23) DNA topoisomerase OS=Caenorhabditis jap...   233   8e-59
Q4Z7C4_PLABA (tr|Q4Z7C4) DNA topoisomerase OS=Plasmodium berghei...   233   1e-58
J9MH64_FUSO4 (tr|J9MH64) Uncharacterized protein OS=Fusarium oxy...   233   1e-58
K9G3X9_PEND1 (tr|K9G3X9) DNA topoisomerase OS=Penicillium digita...   233   1e-58
K9FJW5_PEND2 (tr|K9FJW5) DNA topoisomerase OS=Penicillium digita...   233   1e-58
Q5B4H5_EMENI (tr|Q5B4H5) DNA topoisomerase OS=Emericella nidulan...   233   2e-58
G4URA7_NEUT9 (tr|G4URA7) Prokaryotic type I DNA topoisomerase OS...   232   2e-58
F8MMA1_NEUT8 (tr|F8MMA1) Putative uncharacterized protein OS=Neu...   232   2e-58
M4C198_HYAAE (tr|M4C198) Uncharacterized protein OS=Hyaloperonos...   232   2e-58
N4TL54_FUSOX (tr|N4TL54) DNA topoisomerase 3 OS=Fusarium oxyspor...   232   2e-58
N1RC68_FUSOX (tr|N1RC68) DNA topoisomerase 3 OS=Fusarium oxyspor...   232   2e-58
A5DM60_PICGU (tr|A5DM60) Putative uncharacterized protein OS=Mey...   232   2e-58
R8BQ02_9PEZI (tr|R8BQ02) Putative dna topoisomerase iii protein ...   231   3e-58
G8JT78_ERECY (tr|G8JT78) DNA topoisomerase OS=Eremothecium cymba...   231   4e-58
A4IDA8_LEIIN (tr|A4IDA8) DNA topoisomerase OS=Leishmania infantu...   231   5e-58
F9FBF1_FUSOF (tr|F9FBF1) Uncharacterized protein OS=Fusarium oxy...   231   5e-58
Q4WI92_ASPFU (tr|Q4WI92) DNA topoisomerase OS=Neosartorya fumiga...   231   5e-58
B0XU08_ASPFC (tr|B0XU08) DNA topoisomerase OS=Neosartorya fumiga...   231   5e-58
E1FR69_LOALO (tr|E1FR69) DNA topoisomerase III OS=Loa loa GN=LOA...   231   6e-58
L8G1W2_GEOD2 (tr|L8G1W2) Uncharacterized protein OS=Geomyces des...   230   7e-58
I1BRB7_RHIO9 (tr|I1BRB7) DNA topoisomerase OS=Rhizopus delemar (...   230   9e-58
I7I9L7_BABMI (tr|I7I9L7) Chromosome III, complete sequence OS=Ba...   230   1e-57
A1CYW8_NEOFI (tr|A1CYW8) DNA topoisomerase OS=Neosartorya fische...   229   1e-57
G8YNR8_PICSO (tr|G8YNR8) Piso0_001663 protein OS=Pichia sorbitop...   229   1e-57
A8QH57_BRUMA (tr|A8QH57) DNA topoisomerase III, putative OS=Brug...   229   1e-57
E9BU44_LEIDB (tr|E9BU44) DNA topoisomerase OS=Leishmania donovan...   229   1e-57
C5PFM2_COCP7 (tr|C5PFM2) DNA topoisomerase OS=Coccidioides posad...   229   1e-57
J3KKC0_COCIM (tr|J3KKC0) DNA topoisomerase OS=Coccidioides immit...   229   2e-57
E9DAG1_COCPS (tr|E9DAG1) DNA topoisomerase OS=Coccidioides posad...   229   2e-57
Q4Q199_LEIMA (tr|Q4Q199) DNA topoisomerase OS=Leishmania major G...   229   2e-57
J9FBN9_WUCBA (tr|J9FBN9) DNA topoisomerase OS=Wuchereria bancrof...   229   2e-57
E3RFU2_PYRTT (tr|E3RFU2) DNA topoisomerase OS=Pyrenophora teres ...   229   2e-57
R7YNU0_9EURO (tr|R7YNU0) Uncharacterized protein OS=Coniosporium...   229   2e-57
N4VN06_COLOR (tr|N4VN06) DNA topoisomerase OS=Colletotrichum orb...   229   2e-57
Q0U0G1_PHANO (tr|Q0U0G1) DNA topoisomerase OS=Phaeosphaeria nodo...   228   3e-57
E3KC11_PUCGT (tr|E3KC11) DNA topoisomerase OS=Puccinia graminis ...   228   3e-57
C1MJC0_MICPC (tr|C1MJC0) Predicted protein (Fragment) OS=Micromo...   228   4e-57
M5G9P4_DACSP (tr|M5G9P4) Prokaryotic type I DNA topoisomerase OS...   228   4e-57
A4HPI6_LEIBR (tr|A4HPI6) DNA topoisomerase OS=Leishmania brazili...   228   5e-57
Q4Y492_PLACH (tr|Q4Y492) DNA topoisomerase III, putative OS=Plas...   227   6e-57
M7TEL2_9PEZI (tr|M7TEL2) Putative dna topoisomerase iii protein ...   227   7e-57
D8LV10_BLAHO (tr|D8LV10) Singapore isolate B (sub-type 7) whole ...   227   7e-57
G7KA29_MEDTR (tr|G7KA29) DNA topoisomerase OS=Medicago truncatul...   227   7e-57
C7YNQ3_NECH7 (tr|C7YNQ3) Predicted protein OS=Nectria haematococ...   227   7e-57
G1X646_ARTOA (tr|G1X646) DNA topoisomerase OS=Arthrobotrys oligo...   227   8e-57
G9N9J3_HYPVG (tr|G9N9J3) Uncharacterized protein OS=Hypocrea vir...   227   8e-57
A1CF66_ASPCL (tr|A1CF66) DNA topoisomerase OS=Aspergillus clavat...   227   9e-57
G8YLD9_PICSO (tr|G8YLD9) Piso0_001663 protein OS=Pichia sorbitop...   226   1e-56
R0IZF2_SETTU (tr|R0IZF2) Uncharacterized protein OS=Setosphaeria...   226   2e-56
A7TSV2_VANPO (tr|A7TSV2) DNA topoisomerase OS=Vanderwaltozyma po...   226   2e-56
Q4DNR5_TRYCC (tr|Q4DNR5) DNA topoisomerase OS=Trypanosoma cruzi ...   226   2e-56
C5DKW7_LACTC (tr|C5DKW7) DNA topoisomerase OS=Lachancea thermoto...   226   2e-56
D8Q3K1_SCHCM (tr|D8Q3K1) DNA topoisomerase OS=Schizophyllum comm...   225   2e-56
H3FCH9_PRIPA (tr|H3FCH9) DNA topoisomerase OS=Pristionchus pacif...   225   2e-56
B2VRD7_PYRTR (tr|B2VRD7) DNA topoisomerase OS=Pyrenophora tritic...   225   2e-56
Q5I6D5_TRYCR (tr|Q5I6D5) DNA topoisomerase OS=Trypanosoma cruzi ...   225   3e-56
I1RRJ1_GIBZE (tr|I1RRJ1) Uncharacterized protein OS=Gibberella z...   225   3e-56
Q4DJB7_TRYCC (tr|Q4DJB7) DNA topoisomerase OS=Trypanosoma cruzi ...   225   3e-56
K0KF76_WICCF (tr|K0KF76) DNA topoisomerase OS=Wickerhamomyces ci...   225   3e-56
K3VUV2_FUSPC (tr|K3VUV2) Uncharacterized protein OS=Fusarium pse...   225   3e-56
K2MRY5_TRYCR (tr|K2MRY5) DNA topoisomerase OS=Trypanosoma cruzi ...   224   4e-56
C5DT16_ZYGRC (tr|C5DT16) DNA topoisomerase OS=Zygosaccharomyces ...   224   4e-56
K5W649_PHACS (tr|K5W649) DNA topoisomerase OS=Phanerochaete carn...   224   7e-56
C5M7X1_CANTT (tr|C5M7X1) Putative uncharacterized protein OS=Can...   223   9e-56
M5E9U0_MALSM (tr|M5E9U0) Genomic scaffold, msy_sf_10 OS=Malassez...   223   9e-56
G3AQP6_SPAPN (tr|G3AQP6) DNA topoisomerase OS=Spathaspora passal...   223   9e-56
M3JWC9_CANMA (tr|M3JWC9) Uncharacterized protein OS=Candida malt...   223   1e-55
Q383X7_TRYB2 (tr|Q383X7) DNA topoisomerase OS=Trypanosoma brucei...   223   2e-55
D0A8E9_TRYB9 (tr|D0A8E9) DNA topoisomerase OS=Trypanosoma brucei...   223   2e-55
A4URT1_TRYBB (tr|A4URT1) DNA topoisomerase OS=Trypanosoma brucei...   223   2e-55
J7RTA4_KAZNA (tr|J7RTA4) DNA topoisomerase OS=Kazachstania nagan...   222   3e-55
A7F4Y0_SCLS1 (tr|A7F4Y0) Putative uncharacterized protein OS=Scl...   221   4e-55
R7Q6W3_CHOCR (tr|R7Q6W3) Stackhouse genomic scaffold, scaffold_1...   220   7e-55
B8M6R0_TALSN (tr|B8M6R0) DNA topoisomerase OS=Talaromyces stipit...   220   7e-55
B6Q6V1_PENMQ (tr|B6Q6V1) DNA topoisomerase OS=Penicillium marnef...   219   1e-54
Q6CJ79_KLULA (tr|Q6CJ79) DNA topoisomerase OS=Kluyveromyces lact...   219   1e-54
B0D1N0_LACBS (tr|B0D1N0) DNA topoisomerase OS=Laccaria bicolor (...   219   1e-54
K1VYW4_TRIAC (tr|K1VYW4) Uncharacterized protein OS=Trichosporon...   219   2e-54
N1J751_ERYGR (tr|N1J751) DNA topoisomerase III OS=Blumeria grami...   219   2e-54
B5RUS0_DEBHA (tr|B5RUS0) DEHA2G13376p OS=Debaryomyces hansenii (...   219   2e-54
F9WNV5_TRYVY (tr|F9WNV5) DNA topoisomerase (Fragment) OS=Trypano...   219   2e-54
E3MI31_CAERE (tr|E3MI31) DNA topoisomerase OS=Caenorhabditis rem...   218   4e-54
F9WNR1_TRYVY (tr|F9WNR1) DNA topoisomerase, putative OS=Trypanos...   218   4e-54
L0P8R6_PNEJ8 (tr|L0P8R6) DNA topoisomerase OS=Pneumocystis jirov...   218   5e-54
K2HPK8_ENTNP (tr|K2HPK8) DNA topoisomerase domain containing pro...   218   5e-54
N9V6M2_ENTHI (tr|N9V6M2) DNA topoisomerase 3-alpha, putative OS=...   218   6e-54
M7X249_ENTHI (tr|M7X249) DNA topoisomerase 3-alpha, putative OS=...   218   6e-54
M3TZI6_ENTHI (tr|M3TZI6) DNA topoisomerase domain containing pro...   218   6e-54
M2RJ45_ENTHI (tr|M2RJ45) DNA topoisomerase alpha, putative OS=En...   218   6e-54
C4LZR4_ENTHI (tr|C4LZR4) DNA topoisomerase III, putative OS=Enta...   218   6e-54
E7R471_PICAD (tr|E7R471) DNA topoisomerase OS=Pichia angusta (st...   217   6e-54
F2QNW2_PICP7 (tr|F2QNW2) DNA topoisomerase III OS=Komagataella p...   217   6e-54
C4QWI9_PICPG (tr|C4QWI9) DNA Topoisomerase III, conserved protei...   217   6e-54
G2QE36_THIHA (tr|G2QE36) Uncharacterized protein OS=Thielavia he...   216   1e-53
N1QCT5_9PEZI (tr|N1QCT5) Uncharacterized protein OS=Pseudocercos...   216   1e-53
R1EAR5_9PEZI (tr|R1EAR5) Putative dna topoisomerase iii protein ...   216   2e-53
G8ZXK5_TORDC (tr|G8ZXK5) DNA topoisomerase OS=Torulaspora delbru...   215   3e-53
B0EMC7_ENTDS (tr|B0EMC7) DNA topoisomerase 3-alpha, putative OS=...   215   3e-53
G3J7X2_CORMM (tr|G3J7X2) DNA topoisomerase III OS=Cordyceps mili...   215   4e-53
M7NTA1_9ASCO (tr|M7NTA1) Uncharacterized protein OS=Pneumocystis...   214   4e-53
C4Y396_CLAL4 (tr|C4Y396) DNA topoisomerase OS=Clavispora lusitan...   214   5e-53
K2SJX0_MACPH (tr|K2SJX0) DNA topoisomerase OS=Macrophomina phase...   214   5e-53
G0S5Y3_CHATD (tr|G0S5Y3) DNA topoisomerase-like protein OS=Chaet...   214   5e-53
G0RCU8_HYPJQ (tr|G0RCU8) DNA topoisomerase OS=Hypocrea jecorina ...   214   6e-53
G2YR43_BOTF4 (tr|G2YR43) DNA topoisomerase OS=Botryotinia fuckel...   214   6e-53
M7U3M0_BOTFU (tr|M7U3M0) Putative dna topoisomerase iii protein ...   214   8e-53
H2AZ37_KAZAF (tr|H2AZ37) DNA topoisomerase OS=Kazachstania afric...   214   8e-53
B2AX46_PODAN (tr|B2AX46) Predicted CDS Pa_7_9280 OS=Podospora an...   214   8e-53
C5GWY5_AJEDR (tr|C5GWY5) DNA topoisomerase OS=Ajellomyces dermat...   213   2e-52
E5R045_ARTGP (tr|E5R045) DNA topoisomerase OS=Arthroderma gypseu...   213   2e-52
F2SEP2_TRIRC (tr|F2SEP2) DNA topoisomerase OS=Trichophyton rubru...   212   2e-52
G0WDX5_NAUDC (tr|G0WDX5) DNA topoisomerase OS=Naumovozyma dairen...   212   2e-52
G2WJ61_YEASK (tr|G2WJ61) DNA topoisomerase OS=Saccharomyces cere...   212   2e-52
A7A1B9_YEAS7 (tr|A7A1B9) DNA topoisomerase OS=Saccharomyces cere...   212   2e-52
Q5ANG9_CANAL (tr|Q5ANG9) Likely DNA topoisomerase III OS=Candida...   212   2e-52
C4YQM8_CANAW (tr|C4YQM8) Putative uncharacterized protein OS=Can...   212   3e-52
J4KN74_BEAB2 (tr|J4KN74) DNA topoisomerase OS=Beauveria bassiana...   212   3e-52
G0VCQ8_NAUCC (tr|G0VCQ8) DNA topoisomerase OS=Naumovozyma castel...   212   3e-52
I2H8A8_TETBL (tr|I2H8A8) DNA topoisomerase OS=Tetrapisispora bla...   211   3e-52
F2S5G3_TRIT1 (tr|F2S5G3) DNA topoisomerase OS=Trichophyton tonsu...   211   4e-52
G9P528_HYPAI (tr|G9P528) Putative uncharacterized protein OS=Hyp...   211   4e-52
G3B9F7_CANTC (tr|G3B9F7) DNA topoisomerase OS=Candida tenuis (st...   211   5e-52
C9SVD2_VERA1 (tr|C9SVD2) DNA topoisomerase OS=Verticillium albo-...   211   5e-52
H0GKF7_9SACH (tr|H0GKF7) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
E7LXR9_YEASV (tr|E7LXR9) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
E7KRV8_YEASL (tr|E7KRV8) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
E7KFQ8_YEASA (tr|E7KFQ8) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
C8ZDJ8_YEAS8 (tr|C8ZDJ8) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
C7GR00_YEAS2 (tr|C7GR00) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
B3RHC1_YEAS1 (tr|B3RHC1) DNA topoisomerase OS=Saccharomyces cere...   211   5e-52
F2THD6_AJEDA (tr|F2THD6) DNA topoisomerase OS=Ajellomyces dermat...   211   5e-52
C4IYJ8_MAIZE (tr|C4IYJ8) Uncharacterized protein OS=Zea mays PE=...   211   5e-52
F7VKC6_SORMK (tr|F7VKC6) DNA topoisomerase OS=Sordaria macrospor...   211   6e-52
B5VNF1_YEAS6 (tr|B5VNF1) DNA topoisomerase (Fragment) OS=Sacchar...   211   6e-52
F2PIT5_TRIEC (tr|F2PIT5) DNA topoisomerase OS=Trichophyton equin...   211   7e-52
A8N7S6_COPC7 (tr|A8N7S6) Putative uncharacterized protein OS=Cop...   210   8e-52
G2X7R0_VERDV (tr|G2X7R0) DNA topoisomerase OS=Verticillium dahli...   210   1e-51
F9WKC3_TRYVY (tr|F9WKC3) DNA topoisomerase OS=Trypanosoma vivax ...   210   1e-51
G8BAX5_CANPC (tr|G8BAX5) Putative uncharacterized protein OS=Can...   209   1e-51
A5DZW1_LODEL (tr|A5DZW1) Putative uncharacterized protein OS=Lod...   209   1e-51
Q7RX69_NEUCR (tr|Q7RX69) Putative uncharacterized protein OS=Neu...   209   2e-51
C5JXE5_AJEDS (tr|C5JXE5) DNA topoisomerase OS=Ajellomyces dermat...   209   2e-51
H8X2J6_CANO9 (tr|H8X2J6) Top3 protein OS=Candida orthopsilosis (...   209   2e-51
N1NZV2_YEASX (tr|N1NZV2) Top3p OS=Saccharomyces cerevisiae CEN.P...   209   2e-51
B9WE65_CANDC (tr|B9WE65) DNA topoisomerase III, putative OS=Cand...   208   3e-51
G8BZY0_TETPH (tr|G8BZY0) DNA topoisomerase OS=Tetrapisispora pha...   208   3e-51
G2RC61_THITE (tr|G2RC61) Putative uncharacterized protein OS=Thi...   208   3e-51
A3GHH1_PICST (tr|A3GHH1) DNA topoisomerase OS=Scheffersomyces st...   208   4e-51
A8Q3Y0_MALGO (tr|A8Q3Y0) DNA topoisomerase OS=Malassezia globosa...   208   4e-51
H0GYF0_9SACH (tr|H0GYF0) DNA topoisomerase OS=Saccharomyces cere...   208   4e-51
J8PKR0_SACAR (tr|J8PKR0) DNA topoisomerase OS=Saccharomyces arbo...   208   4e-51
G4MUA4_MAGO7 (tr|G4MUA4) DNA topoisomerase OS=Magnaporthe oryzae...   207   5e-51
L7JG16_MAGOR (tr|L7JG16) DNA topoisomerase OS=Magnaporthe oryzae...   206   1e-50
L7IMH5_MAGOR (tr|L7IMH5) DNA topoisomerase OS=Magnaporthe oryzae...   206   1e-50
M4G6R8_MAGP6 (tr|M4G6R8) DNA topoisomerase OS=Magnaporthe poae (...   206   1e-50
A3FQH8_CRYPI (tr|A3FQH8) DNA topoisomerase III, putative OS=Cryp...   206   2e-50
A2DNF5_TRIVA (tr|A2DNF5) DNA topoisomerase OS=Trichomonas vagina...   206   2e-50
F2SZF7_TRIRC (tr|F2SZF7) DNA topoisomerase OS=Trichophyton rubru...   206   2e-50
F0XQ46_GROCL (tr|F0XQ46) DNA topoisomerase OS=Grosmannia clavige...   205   3e-50
A2FIZ8_TRIVA (tr|A2FIZ8) DNA topoisomerase OS=Trichomonas vagina...   205   4e-50
E5AA49_LEPMJ (tr|E5AA49) DNA topoisomerase OS=Leptosphaeria macu...   204   5e-50
G0V1K6_TRYCI (tr|G0V1K6) DNA topoisomerase OS=Trypanosoma congol...   204   6e-50
J3NKL3_GAGT3 (tr|J3NKL3) DNA topoisomerase OS=Gaeumannomyces gra...   203   9e-50
M2W229_GALSU (tr|M2W229) DNA topoisomerase OS=Galdieria sulphura...   203   1e-49
E3Q8J2_COLGM (tr|E3Q8J2) DNA topoisomerase OS=Colletotrichum gra...   201   3e-49
Q4X726_PLACH (tr|Q4X726) Putative uncharacterized protein (Fragm...   201   4e-49
E4V4B0_ARTGP (tr|E4V4B0) DNA topoisomerase OS=Arthroderma gypseu...   199   2e-48
N1Q2F9_MYCPJ (tr|N1Q2F9) Uncharacterized protein OS=Dothistroma ...   199   2e-48
Q6FSR2_CANGA (tr|Q6FSR2) DNA topoisomerase OS=Candida glabrata (...   197   5e-48
N4XLP8_COCHE (tr|N4XLP8) Uncharacterized protein OS=Bipolaris ma...   197   7e-48
M2UQN7_COCHE (tr|M2UQN7) DNA topoisomerase OS=Bipolaris maydis C...   197   7e-48
E0S6Q9_ENCIT (tr|E0S6Q9) DNA topoisomerase III OS=Encephalitozoo...   197   8e-48
M1JIJ8_ENCCN (tr|M1JIJ8) DNA topoisomerase III OS=Encephalitozoo...   197   8e-48
Q8SS31_ENCCU (tr|Q8SS31) DNA TOPOISOMERASE III OS=Encephalitozoo...   197   1e-47
J5Q6M3_TRIAS (tr|J5Q6M3) DNA topoisomerase 3-beta OS=Trichosporo...   196   2e-47
K1WRC8_MARBU (tr|K1WRC8) DNA topoisomerase OS=Marssonina brunnea...   195   3e-47
M2SU74_COCSA (tr|M2SU74) DNA topoisomerase OS=Bipolaris sorokini...   195   3e-47
D4DCV0_TRIVH (tr|D4DCV0) DNA topoisomerase OS=Trichophyton verru...   193   9e-47
I6UL40_ENCHA (tr|I6UL40) Topoisomerase IA OS=Encephalitozoon hel...   193   1e-46
N1QMM7_9PEZI (tr|N1QMM7) DNA topoisomerase OS=Mycosphaerella pop...   193   1e-46
C5LX61_PERM5 (tr|C5LX61) DNA topoisomerase III, putative (Fragme...   190   1e-45
E0VDP5_PEDHC (tr|E0VDP5) DNA topoisomerase OS=Pediculus humanus ...   190   1e-45
C5FLE2_ARTOC (tr|C5FLE2) DNA topoisomerase III OS=Arthroderma ot...   189   2e-45
I7AR84_ENCRO (tr|I7AR84) DNA topoisomerase II OS=Encephalitozoon...   189   3e-45
M2NMF1_9PEZI (tr|M2NMF1) DNA topoisomerase OS=Baudoinia compniac...   188   5e-45
B6ADG7_CRYMR (tr|B6ADG7) DNA topoisomerase OS=Cryptosporidium mu...   187   8e-45
L2GKR2_VITCO (tr|L2GKR2) Uncharacterized protein OS=Vittaforma c...   187   8e-45
D4B2Z5_ARTBC (tr|D4B2Z5) DNA topoisomerase OS=Arthroderma benham...   186   1e-44
R0MEX3_NOSBO (tr|R0MEX3) DNA topoisomerase 3-alpha OS=Nosema bom...   186   2e-44
C7NPP6_HALUD (tr|C7NPP6) DNA topoisomerase OS=Halorhabdus utahen...   184   6e-44
R1G787_EMIHU (tr|R1G787) Uncharacterized protein OS=Emiliania hu...   184   8e-44
F7PNB3_9EURY (tr|F7PNB3) DNA topoisomerase OS=Halorhabdus tiamat...   182   2e-43
R0M9K0_NOSBO (tr|R0M9K0) DNA topoisomerase 3-alpha OS=Nosema bom...   181   4e-43
F7ADD1_CALJA (tr|F7ADD1) DNA topoisomerase OS=Callithrix jacchus...   180   9e-43
G1T303_RABIT (tr|G1T303) DNA topoisomerase OS=Oryctolagus cunicu...   179   2e-42
E1ZIK6_CHLVA (tr|E1ZIK6) DNA topoisomerase OS=Chlorella variabil...   179   3e-42
C4VAL6_NOSCE (tr|C4VAL6) Putative uncharacterized protein OS=Nos...   178   4e-42
D4B4S3_ARTBC (tr|D4B4S3) Putative uncharacterized protein OS=Art...   178   4e-42
H2R4A2_PANTR (tr|H2R4A2) DNA topoisomerase OS=Pan troglodytes GN...   177   6e-42
E2BPS8_HARSA (tr|E2BPS8) DNA topoisomerase OS=Harpegnathos salta...   177   7e-42
H0Y6W0_HUMAN (tr|H0Y6W0) DNA topoisomerase (Fragment) OS=Homo sa...   177   7e-42
H0XH52_OTOGA (tr|H0XH52) DNA topoisomerase OS=Otolemur garnettii...   177   9e-42
D4A9Z2_RAT (tr|D4A9Z2) DNA topoisomerase OS=Rattus norvegicus GN...   176   2e-41
I3NC26_SPETR (tr|I3NC26) DNA topoisomerase OS=Spermophilus tride...   176   2e-41
A8J6M3_CHLRE (tr|A8J6M3) DNA topoisomerase (Fragment) OS=Chlamyd...   176   2e-41
H9EST7_MACMU (tr|H9EST7) DNA topoisomerase OS=Macaca mulatta GN=...   176   2e-41
G5BKF9_HETGA (tr|G5BKF9) DNA topoisomerase OS=Heterocephalus gla...   176   2e-41
G7PHB7_MACFA (tr|G7PHB7) DNA topoisomerase OS=Macaca fasciculari...   176   2e-41
F7GH88_MACMU (tr|F7GH88) DNA topoisomerase OS=Macaca mulatta GN=...   176   2e-41
F6QNQ6_MACMU (tr|F6QNQ6) DNA topoisomerase OS=Macaca mulatta GN=...   176   2e-41
Q7YYF5_CRYPV (tr|Q7YYF5) DNA topoisomerase OS=Cryptosporidium pa...   176   2e-41
A3FPU5_CRYPI (tr|A3FPU5) DNA topoisomerase OS=Cryptosporidium pa...   176   2e-41
H2P4Z3_PONAB (tr|H2P4Z3) DNA topoisomerase OS=Pongo abelii GN=TO...   175   3e-41
Q3UJF5_MOUSE (tr|Q3UJF5) DNA topoisomerase OS=Mus musculus GN=To...   175   3e-41
D7E725_METEZ (tr|D7E725) DNA topoisomerase OS=Methanohalobium ev...   175   3e-41
E1QRL6_VULDI (tr|E1QRL6) DNA topoisomerase OS=Vulcanisaeta distr...   175   3e-41
G1TFH8_RABIT (tr|G1TFH8) DNA topoisomerase OS=Oryctolagus cunicu...   174   4e-41
M0K7F5_9EURY (tr|M0K7F5) DNA topoisomerase OS=Haloarcula amyloly...   174   5e-41
A8K4N2_HUMAN (tr|A8K4N2) DNA topoisomerase OS=Homo sapiens PE=2 ...   174   5e-41
F6SDD7_MOUSE (tr|F6SDD7) DNA topoisomerase (Fragment) OS=Mus mus...   174   6e-41
M3VYV1_FELCA (tr|M3VYV1) DNA topoisomerase OS=Felis catus GN=TOP...   174   6e-41
G8F1W3_MACMU (tr|G8F1W3) DNA topoisomerase OS=Macaca mulatta GN=...   174   6e-41
C3Z1Q7_BRAFL (tr|C3Z1Q7) DNA topoisomerase OS=Branchiostoma flor...   174   8e-41
G3HFY0_CRIGR (tr|G3HFY0) DNA topoisomerase OS=Cricetulus griseus...   174   8e-41
L8X3P3_9HOMO (tr|L8X3P3) DNA topoisomerase type I OS=Rhizoctonia...   174   9e-41
M3XVK3_MUSPF (tr|M3XVK3) DNA topoisomerase OS=Mustela putorius f...   173   1e-40
M5XLX9_PRUPE (tr|M5XLX9) Uncharacterized protein OS=Prunus persi...   173   1e-40
G9KUN5_MUSPF (tr|G9KUN5) DNA topoisomerase (Fragment) OS=Mustela...   173   1e-40
G1LLS2_AILME (tr|G1LLS2) DNA topoisomerase OS=Ailuropoda melanol...   173   1e-40
K3WPG6_PYTUL (tr|K3WPG6) DNA topoisomerase OS=Pythium ultimum GN...   173   1e-40
I0YWU4_9CHLO (tr|I0YWU4) DNA topoisomerase OS=Coccomyxa subellip...   173   1e-40
D2I7M2_AILME (tr|D2I7M2) DNA topoisomerase (Fragment) OS=Ailurop...   173   1e-40
E2R770_CANFA (tr|E2R770) DNA topoisomerase OS=Canis familiaris G...   173   1e-40
Q384B1_TRYB2 (tr|Q384B1) DNA topoisomerase III, putative OS=Tryp...   173   1e-40
D0A8A5_TRYB9 (tr|D0A8A5) DNA topoisomerase III, putative OS=Tryp...   173   1e-40

>K7KV90_SOYBN (tr|K7KV90) DNA topoisomerase OS=Glycine max PE=3 SV=1
          Length = 913

 Score =  752 bits (1942), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 354/421 (84%), Positives = 382/421 (90%), Gaps = 2/421 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LH IVQEQQGHPEWGIYAQRL+DPEAGLWRNP
Sbjct: 321 MKVAEELYQAGFISYPRTETDSFSPGTDLHTIVQEQQGHPEWGIYAQRLMDPEAGLWRNP 380

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           RGGGHDDKAHPPI+PTKFS GESGWSQ+HRKLYELVVRHFLACVSKPA+GAETTVEI+IA
Sbjct: 381 RGGGHDDKAHPPIYPTKFSTGESGWSQDHRKLYELVVRHFLACVSKPALGAETTVEINIA 440

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GELFSACGRVILEKNYLDVY +E+WGGS+IPTYT GQQF PT LTL+SGVTRPPPLLSEA
Sbjct: 441 GELFSACGRVILEKNYLDVYRYESWGGSMIPTYTNGQQFNPTKLTLESGVTRPPPLLSEA 500

Query: 192 DLLSCMDKE--GIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           DLLS MD+E   IGTDATM DHIKK+LDR YATKD+STRFTPTNLGEALV+GYDDI+M Y
Sbjct: 501 DLLSYMDREEAKIGTDATMQDHIKKMLDRSYATKDSSTRFTPTNLGEALVLGYDDIDMTY 560

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
           KLWKP+LRS ME  M  V +G K K  VL T L KM+ACFL ARLNKVKLLEAM+IFF+R
Sbjct: 561 KLWKPDLRSEMEKKMDDVKKGDKSKAEVLVTILQKMEACFLEARLNKVKLLEAMAIFFER 620

Query: 310 SNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
           S RS+ DELHATGEVVRRCGLCQESDM+L+KNRDGNFMVGC+G+PQCRNAVWLPGSVSEA
Sbjct: 621 STRSSSDELHATGEVVRRCGLCQESDMLLRKNRDGNFMVGCMGYPQCRNAVWLPGSVSEA 680

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPRMP 429
            VTTN CNFCTPGPVY IQ KFR+LEIPPNY+ NHLGCIGGCDEIL QLTEICG GPRMP
Sbjct: 681 VVTTNTCNFCTPGPVYLIQFKFRRLEIPPNYSPNHLGCIGGCDEILAQLTEICGRGPRMP 740

Query: 430 G 430
            
Sbjct: 741 A 741


>B9H4K8_POPTR (tr|B9H4K8) DNA topoisomerase OS=Populus trichocarpa
           GN=POPTRDRAFT_861019 PE=3 SV=1
          Length = 910

 Score =  703 bits (1814), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 335/419 (79%), Positives = 358/419 (85%), Gaps = 2/419 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAE+LYQ GFISYPRTETDSFS RT+LH IVQE Q HP WG YAQRLLDP AGLWRNP
Sbjct: 321 MKVAEDLYQAGFISYPRTETDSFSSRTDLHTIVQEHQEHPVWGSYAQRLLDPGAGLWRNP 380

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGES WSQ+H +LYELVVRHFLACVS+PAVGAET VEIDIA
Sbjct: 381 SNGGHDDKAHPPIHPTKFSAGESRWSQDHHRLYELVVRHFLACVSQPAVGAETVVEIDIA 440

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA GRVIL KNYLDVY FE+WG S+IPTY  GQQF P  LTLDSGVTRPPPLLSEA
Sbjct: 441 GERFSASGRVILAKNYLDVYRFESWGDSMIPTYLQGQQFIPATLTLDSGVTRPPPLLSEA 500

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDRFY TKDA+TRF+PTNLGEALVMGYDD  M Y+L
Sbjct: 501 DLLSCMDKAGIGTDATMHDHIKKLLDRFYVTKDANTRFSPTNLGEALVMGYDD--MGYEL 558

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME DMK VS G K K  VLAT L +MKACFL A++NKVKLLEAM+IFF RS+
Sbjct: 559 WKPNLRSLMECDMKEVSVGNKSKAEVLATCLQQMKACFLDAKVNKVKLLEAMAIFFNRSD 618

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           RS GD+  A GE VR CGLCQE++MVLKKNRDGNFMVGC GFPQCRNAVWLPG V EA +
Sbjct: 619 RSNGDDSSALGENVRPCGLCQEANMVLKKNRDGNFMVGCSGFPQCRNAVWLPGPVLEATI 678

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPRMPG 430
           T N CN CTPGPVY IQ KFRQLEIPP +N+NHLGCIGGCDE LRQL EICGTG R+ G
Sbjct: 679 TNNICNSCTPGPVYLIQFKFRQLEIPPGFNVNHLGCIGGCDETLRQLIEICGTGSRVQG 737


>B9SN22_RICCO (tr|B9SN22) DNA topoisomerase (Fragment) OS=Ricinus communis
           GN=RCOM_1519060 PE=3 SV=1
          Length = 833

 Score =  701 bits (1809), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 322/417 (77%), Positives = 368/417 (88%), Gaps = 2/417 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAE+LYQ+GFISYPRTETD FS RT+LH IV++QQ HP WG YAQRLLDP  GLWRNP
Sbjct: 323 MKVAEDLYQSGFISYPRTETDGFSSRTDLHTIVRDQQAHPIWGSYAQRLLDPGTGLWRNP 382

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+GWSQ+H ++YELVVRHFLACVS+PAVGAETTVEIDIA
Sbjct: 383 STGGHDDKAHPPIHPTKFSPGETGWSQDHHRVYELVVRHFLACVSQPAVGAETTVEIDIA 442

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA GRVIL KNYLDVY FE+WGGS+IPTY  GQQF PT LTLDSGVTRPPPLLSE+
Sbjct: 443 GEQFSASGRVILAKNYLDVYRFESWGGSMIPTYVHGQQFMPTTLTLDSGVTRPPPLLSES 502

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDRFYATKDA+TRF+PTNLGEALVMGYDD  M Y+L
Sbjct: 503 DLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDANTRFSPTNLGEALVMGYDD--MGYEL 560

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME DMK VS G K K  VL T L +MK CFL AR+NKVKLLEAM++FF+RS+
Sbjct: 561 WKPNLRSMMEYDMKEVSMGHKSKAEVLETCLQQMKTCFLDARINKVKLLEAMAVFFERSD 620

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           RS+G++ HAT ++VR+CGLC+E++MVL++NRDGNFMVGC+G+PQCRNA+WLPG + EA V
Sbjct: 621 RSSGNDNHATVDIVRQCGLCRETNMVLRRNRDGNFMVGCMGYPQCRNAIWLPGPIIEATV 680

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPRM 428
           TT+ CN+CTPGPVY IQ KFRQLEIPP +++NHLGCIGGCD+ LRQLT+ICGTG R+
Sbjct: 681 TTSVCNYCTPGPVYLIQFKFRQLEIPPGFSVNHLGCIGGCDDTLRQLTDICGTGSRV 737


>K7KV93_SOYBN (tr|K7KV93) Uncharacterized protein OS=Glycine max PE=3 SV=1
          Length = 885

 Score =  699 bits (1804), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 328/393 (83%), Positives = 355/393 (90%), Gaps = 2/393 (0%)

Query: 40  LHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQN 99
           +  IVQEQQGHPEWGIYAQRL+DPEAGLWRNPRGGGHDDKAHPPI+PTKFS GESGWSQ+
Sbjct: 321 MKTIVQEQQGHPEWGIYAQRLMDPEAGLWRNPRGGGHDDKAHPPIYPTKFSTGESGWSQD 380

Query: 100 HRKLYELVVRHFLACVSKPAVGAETTVEIDIAGELFSACGRVILEKNYLDVYPFETWGGS 159
           HRKLYELVVRHFLACVSKPA+GAETTVEI+IAGELFSACGRVILEKNYLDVY +E+WGGS
Sbjct: 381 HRKLYELVVRHFLACVSKPALGAETTVEINIAGELFSACGRVILEKNYLDVYRYESWGGS 440

Query: 160 LIPTYTVGQQFTPTALTLDSGVTRPPPLLSEADLLSCMDKE--GIGTDATMHDHIKKLLD 217
           +IPTYT GQQF PT LTL+SGVTRPPPLLSEADLLS MD+E   IGTDATM DHIKK+LD
Sbjct: 441 MIPTYTNGQQFNPTKLTLESGVTRPPPLLSEADLLSYMDREEAKIGTDATMQDHIKKMLD 500

Query: 218 RFYATKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAV 277
           R YATKD+STRFTPTNLGEALV+GYDDI+M YKLWKP+LRS ME  M  V +G K K  V
Sbjct: 501 RSYATKDSSTRFTPTNLGEALVLGYDDIDMTYKLWKPDLRSEMEKKMDDVKKGDKSKAEV 560

Query: 278 LATSLDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGDELHATGEVVRRCGLCQESDMV 337
           L T L KM+ACFL ARLNKVKLLEAM+IFF+RS RS+ DELHATGEVVRRCGLCQESDM+
Sbjct: 561 LVTILQKMEACFLEARLNKVKLLEAMAIFFERSTRSSSDELHATGEVVRRCGLCQESDML 620

Query: 338 LKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIP 397
           L+KNRDGNFMVGC+G+PQCRNAVWLPGSVSEA VTTN CNFCTPGPVY IQ KFR+LEIP
Sbjct: 621 LRKNRDGNFMVGCMGYPQCRNAVWLPGSVSEAVVTTNTCNFCTPGPVYLIQFKFRRLEIP 680

Query: 398 PNYNINHLGCIGGCDEILRQLTEICGTGPRMPG 430
           PNY+ NHLGCIGGCDEIL QLTEICG GPRMP 
Sbjct: 681 PNYSPNHLGCIGGCDEILAQLTEICGRGPRMPA 713


>D7U4C0_VITVI (tr|D7U4C0) Putative uncharacterized protein OS=Vitis vinifera
           GN=VIT_04s0044g01570 PE=3 SV=1
          Length = 589

 Score =  667 bits (1722), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 311/387 (80%), Positives = 345/387 (89%), Gaps = 2/387 (0%)

Query: 42  AIVQEQQGHPEWGIYAQRLLDPEAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHR 101
            IVQEQ GHP WG YAQRLLDP AGLWRNP  GGHDDKAHPPIHPTKFSAGESGWSQ+H+
Sbjct: 25  GIVQEQLGHPIWGSYAQRLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHQ 84

Query: 102 KLYELVVRHFLACVSKPAVGAETTVEIDIAGELFSACGRVILEKNYLDVYPFETWGGSLI 161
           +LYELVVRHFLACVS+PAVGAET VEIDIAGE FS+ GRVI+ KNYLDVY FE+WGGS+I
Sbjct: 85  RLYELVVRHFLACVSQPAVGAETIVEIDIAGESFSSSGRVIIAKNYLDVYRFESWGGSMI 144

Query: 162 PTYTVGQQFTPTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA 221
           PTY  GQQF PT LTLDSGVTRPPPLLSEADLL+CMDK GIGTDATMHDHIKKLLDRFYA
Sbjct: 145 PTYVFGQQFIPTTLTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRFYA 204

Query: 222 TKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATS 281
           TKD++TRF+PTNLGEALVMGYDD  M Y+LWKP LRS ME DMK+VS GTK ++ VL T 
Sbjct: 205 TKDSNTRFSPTNLGEALVMGYDD--MGYELWKPYLRSMMECDMKAVSIGTKRRNEVLTTC 262

Query: 282 LDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKN 341
           L++MKACFL ARLNKVKLLEAM++FF+RSNRS+GDE H  G+VVR+C LCQESDMVL++ 
Sbjct: 263 LEQMKACFLDARLNKVKLLEAMALFFERSNRSSGDEQHEVGDVVRQCTLCQESDMVLRRK 322

Query: 342 RDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYN 401
            DGNFMVGCLG+PQCRN VWLPGS+SEAA+TT  CN CTPGPVY+IQ KFR+LEIPPNYN
Sbjct: 323 PDGNFMVGCLGYPQCRNVVWLPGSISEAAITTISCNHCTPGPVYKIQFKFRRLEIPPNYN 382

Query: 402 INHLGCIGGCDEILRQLTEICGTGPRM 428
           I+HLGC+ GCDEILRQLTEICGTG R+
Sbjct: 383 IDHLGCVCGCDEILRQLTEICGTGSRI 409


>M0T393_MUSAM (tr|M0T393) DNA topoisomerase OS=Musa acuminata subsp. malaccensis
           PE=3 SV=1
          Length = 929

 Score =  659 bits (1700), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 317/422 (75%), Positives = 357/422 (84%), Gaps = 7/422 (1%)

Query: 4   VAYTLFKFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDP 63
           V Y    FL +AEELYQ GFISYPRTETD FS  T+LHAIV+EQ  HP WG YAQ+LLD 
Sbjct: 333 VRYKHSCFL-IAEELYQAGFISYPRTETDGFSVNTDLHAIVREQVTHPIWGSYAQQLLDV 391

Query: 64  EAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAE 123
           EA LWRNP  GGHDDKAHPPIHPTKFSAGE+GWSQ+H +LYELVVRHFLACVS+PAVGAE
Sbjct: 392 EARLWRNPSNGGHDDKAHPPIHPTKFSAGETGWSQDHNRLYELVVRHFLACVSQPAVGAE 451

Query: 124 TTVEIDIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTR 183
           TTVEIDIAGE FSA GRVI+ KNYLDVY FE+WGG+++PTYT+GQQF PT+LTLDSGVTR
Sbjct: 452 TTVEIDIAGEQFSASGRVIIAKNYLDVYRFESWGGNIVPTYTIGQQFIPTSLTLDSGVTR 511

Query: 184 PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYD 243
           PPPLLSEADLLSCMDK GIGTDATMHDHIKKLLDR YATKD++TRF+PTNLGEALVMGYD
Sbjct: 512 PPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRCYATKDSNTRFSPTNLGEALVMGYD 571

Query: 244 DIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAM 303
             EM Y+LWKP LR+ ME DMK+VS GTK K  VL + L +MKACFL AR NKVKLLEAM
Sbjct: 572 --EMGYELWKPYLRAMMECDMKAVSIGTKRKSEVLESCLQQMKACFLDARRNKVKLLEAM 629

Query: 304 SIFFQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLP 363
            +FF+   RSAGD  H  GE VR C LC E+DMVLK+  +G++MVGCL FP CRN VWLP
Sbjct: 630 GLFFE---RSAGDA-HNVGETVRPCSLCSEADMVLKRRLNGDYMVGCLRFPNCRNVVWLP 685

Query: 364 GSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICG 423
           GS+SEAAVT + C+ C PGPVY++Q KFR+LEIPPNY+++HLGCIGGCD ILR+L EICG
Sbjct: 686 GSISEAAVTNHVCSSCAPGPVYKVQFKFRRLEIPPNYDVDHLGCIGGCDVILRELIEICG 745

Query: 424 TG 425
           TG
Sbjct: 746 TG 747


>Q9LVP1_ARATH (tr|Q9LVP1) DNA topoisomerase OS=Arabidopsis thaliana GN=TOP3A PE=2
           SV=1
          Length = 926

 Score =  655 bits (1691), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 307/416 (73%), Positives = 344/416 (82%), Gaps = 2/416 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFS RT+L A+V+EQ  HP WG YAQRLL+PE GLWRNP
Sbjct: 328 MKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNP 387

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS+GES WS++H  +YELVVRH+LACVS+PAV AETTVEIDIA
Sbjct: 388 ANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIA 447

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA GR IL KNYL+VY FE+WGGS+IP Y  GQQF PT LTLD+ VTRPPPLL EA
Sbjct: 448 GERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEA 507

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYDD  M Y+L
Sbjct: 508 DLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDD--MGYEL 565

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME DM  VS G K K  VL T L +MKACFL AR+ K KLLEAM+IFF+RSN
Sbjct: 566 WKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSN 625

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
            +   E    GEVVRRC LC ESDM L+KNRDGNFMVGC+ +PQCRNAVWLPG   EA+V
Sbjct: 626 NTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASV 685

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
           TTN C  C PGPVY+I  KFRQ+ IPP +++NHLGC+GGCD+IL+QL +ICGTG R
Sbjct: 686 TTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSR 741


>M4ET14_BRARP (tr|M4ET14) DNA topoisomerase OS=Brassica rapa subsp. pekinensis
           GN=Bra031944 PE=3 SV=1
          Length = 921

 Score =  655 bits (1691), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 306/416 (73%), Positives = 345/416 (82%), Gaps = 2/416 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFS RT+L A+V+EQ  HP WG YAQRLL+PE GLWRNP
Sbjct: 329 MKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGPYAQRLLEPEGGLWRNP 388

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS+GES WS++H  +YELVVRH+LACVS+PAV AETTVEIDIA
Sbjct: 389 GNGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIA 448

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA GR IL KNYL+VY FE+WGGS+IP Y  GQQF PT LTLDS VTRPPPLL EA
Sbjct: 449 GERFSASGRAILAKNYLEVYRFESWGGSMIPVYEKGQQFIPTRLTLDSAVTRPPPLLCEA 508

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYDD  M Y+L
Sbjct: 509 DLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDD--MGYEL 566

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME DM  VS G K K  VL T L +MKACFL AR+ K KLLEAM+IFF+RSN
Sbjct: 567 WKPNLRAIMEHDMNEVSVGNKTKAEVLETCLQQMKACFLDARVKKTKLLEAMTIFFERSN 626

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
            S   E    GEVVRRC LC ESDM L+KN+DGNFMVGC+ +PQCRNAVWLPG   EA+V
Sbjct: 627 NSDEGENQTAGEVVRRCNLCHESDMALRKNQDGNFMVGCMSYPQCRNAVWLPGPTLEASV 686

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
           TT+ C  C PGPVY+I+ KFRQ+ IPP +++NHLGC+GGCD++L+QL +ICGTG R
Sbjct: 687 TTDTCQSCGPGPVYKIRFKFRQIRIPPGFDVNHLGCVGGCDDVLKQLIDICGTGSR 742


>R0GNU4_9BRAS (tr|R0GNU4) Uncharacterized protein OS=Capsella rubella
           GN=CARUB_v10025845mg PE=4 SV=1
          Length = 919

 Score =  654 bits (1688), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 307/416 (73%), Positives = 344/416 (82%), Gaps = 2/416 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FS RT+L A+V+EQ  HPEWG YAQRLL+PE GLWRNP
Sbjct: 328 MKVAEELYQAGFISYPRTETDAFSSRTDLRAMVEEQTRHPEWGAYAQRLLEPEGGLWRNP 387

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS+GES WS++H  +YELVVRH+LACVS+PAV AETTVEIDI+
Sbjct: 388 GNGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIS 447

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA GR IL KNYL+VY FE+WGGS+IP Y  GQQF PT+LTLDS VTRPPPLL EA
Sbjct: 448 GERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTSLTLDSAVTRPPPLLCEA 507

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYDD  M Y+L
Sbjct: 508 DLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDD--MGYEL 565

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME DM  VS G K K  VL T L +MKACFL AR+ K KLLEAM+IFF+RSN
Sbjct: 566 WKPNLRAIMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSN 625

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
            +   E    GEVVRRC LC ESDM L+KNRDGNFMVGC+ +PQCRNAVWLPG   EA+V
Sbjct: 626 NTDEGENQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASV 685

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
           TTN C  C PGPVY+I  KFRQ+ IPP + +NHLGC+GGCD IL+QL +ICGTG R
Sbjct: 686 TTNVCQSCGPGPVYKILFKFRQIGIPPGFEVNHLGCVGGCDGILKQLIDICGTGSR 741


>D7MQJ2_ARALL (tr|D7MQJ2) DNA topoisomerase OS=Arabidopsis lyrata subsp. lyrata
           GN=ARALYDRAFT_496584 PE=3 SV=1
          Length = 923

 Score =  651 bits (1680), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 306/416 (73%), Positives = 344/416 (82%), Gaps = 2/416 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFS RT+L A+V+EQ+ HP WG YAQRLL+PE GLWRNP
Sbjct: 328 MKVAEELYQAGFISYPRTETDSFSSRTDLCAMVEEQRRHPAWGSYAQRLLEPEGGLWRNP 387

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS+GES WS++H  +YELVVRH+LACVS+PA  AETTVEIDIA
Sbjct: 388 GNGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAKAAETTVEIDIA 447

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA GR IL KNYL+VY FE+WGGS+IP Y  GQQF PT LTLDS VTRPPPLL EA
Sbjct: 448 GERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTTLTLDSAVTRPPPLLCEA 507

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYDD  M Y+L
Sbjct: 508 DLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDD--MGYEL 565

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME DM  VS G K K  VL T L +MKACFL AR+ K KLLEAM+IFF+RSN
Sbjct: 566 WKPNLRALMERDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSN 625

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
            +   E    GEV+RRC LC ESDM L+KNRDGNFMVGC+ +PQCRNAVWLPG   EA+V
Sbjct: 626 NTDESESQTAGEVIRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASV 685

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
           TT+ C  C PGPVY+I  KFRQ+ IPP +++NHLGCIGGCD+IL+QL +ICGTG R
Sbjct: 686 TTDVCQTCGPGPVYKILFKFRQIGIPPGFDVNHLGCIGGCDDILKQLIDICGTGSR 741


>J3LKB1_ORYBR (tr|J3LKB1) DNA topoisomerase OS=Oryza brachyantha GN=OB03G14870
           PE=3 SV=1
          Length = 925

 Score =  646 bits (1667), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 307/414 (74%), Positives = 346/414 (83%), Gaps = 3/414 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LH+IVQEQ  HP WG YAQRLLDPEA LWRNP
Sbjct: 330 MKVAEELYQAGFISYPRTETDNFSPNTDLHSIVQEQTAHPVWGTYAQRLLDPEARLWRNP 389

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ WS NH+KLYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 390 SNGGHDDKAHPPIHPTKFSAGETNWSDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIA 449

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTYT+GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 450 GEQFNASGRVVLSKNYLDVYRFDSWGGTLLPTYTIGQQFIPTTLTLDSGVTRPPPLLAEA 509

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 510 DLLSCMDKAGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYD--EMGYEL 567

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF RS+
Sbjct: 568 WKPYLRSMMEADMKSVSIGTKSKAEVLENCLQQMKACFLDARANKVKLFDAMGAFFARSS 627

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   + E VR C  C ES+MVLK+   G FMVGC GFPQCRN VWLPGS+SEA+V
Sbjct: 628 RPI-NETQNSIEAVRPCAACNESEMVLKRRPTGEFMVGCRGFPQCRNVVWLPGSLSEASV 686

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           T   C  C PGPVY+IQ KFR+ +IPP+++++HLGCIGGCD+IL++LTEI   G
Sbjct: 687 TDQVCPTCAPGPVYKIQFKFRRRDIPPSFDVDHLGCIGGCDDILKELTEISRFG 740


>M0WQP1_HORVD (tr|M0WQP1) DNA topoisomerase OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 854

 Score =  640 bits (1650), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 299/410 (72%), Positives = 346/410 (84%), Gaps = 3/410 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LHAIV+EQ  HP+WG YAQRLL+PE  LWRNP
Sbjct: 326 MKVAEELYQAGFISYPRTETDSFSPNTDLHAIVREQADHPDWGTYAQRLLNPEERLWRNP 385

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H+KLYELVVRHFLAC S+PAVGAETTVE+DIA
Sbjct: 386 SNGGHDDKAHPPIHPTKFSTGENNWSPDHKKLYELVVRHFLACCSQPAVGAETTVEVDIA 445

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 446 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 505

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNLGEALVMGYD  EM Y+L
Sbjct: 506 DLLSCMDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLGEALVMGYD--EMGYEL 563

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RSN
Sbjct: 564 WKPYLRAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFARSN 623

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   T EVVR CG C ES+M+LK+  +G FMVGC GFPQCRN VWLPGSV+EAAV
Sbjct: 624 RPI-NETQTTIEVVRPCGACNESEMLLKRRPNGGFMVGCRGFPQCRNVVWLPGSVAEAAV 682

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           T   C  C PGPVY+IQ KF + +IPP+++++HLGC+GGCD++L++LTE+
Sbjct: 683 TQQICPTCVPGPVYKIQFKFNRRDIPPSFDVDHLGCVGGCDDVLKELTEM 732


>M0WQP4_HORVD (tr|M0WQP4) DNA topoisomerase OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 915

 Score =  639 bits (1647), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 299/410 (72%), Positives = 346/410 (84%), Gaps = 3/410 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LHAIV+EQ  HP+WG YAQRLL+PE  LWRNP
Sbjct: 326 MKVAEELYQAGFISYPRTETDSFSPNTDLHAIVREQADHPDWGTYAQRLLNPEERLWRNP 385

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H+KLYELVVRHFLAC S+PAVGAETTVE+DIA
Sbjct: 386 SNGGHDDKAHPPIHPTKFSTGENNWSPDHKKLYELVVRHFLACCSQPAVGAETTVEVDIA 445

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 446 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 505

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNLGEALVMGYD  EM Y+L
Sbjct: 506 DLLSCMDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLGEALVMGYD--EMGYEL 563

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RSN
Sbjct: 564 WKPYLRAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFARSN 623

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   T EVVR CG C ES+M+LK+  +G FMVGC GFPQCRN VWLPGSV+EAAV
Sbjct: 624 RPI-NETQTTIEVVRPCGACNESEMLLKRRPNGGFMVGCRGFPQCRNVVWLPGSVAEAAV 682

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           T   C  C PGPVY+IQ KF + +IPP+++++HLGC+GGCD++L++LTE+
Sbjct: 683 TQQICPTCVPGPVYKIQFKFNRRDIPPSFDVDHLGCVGGCDDVLKELTEM 732


>M0WQP3_HORVD (tr|M0WQP3) DNA topoisomerase OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 917

 Score =  639 bits (1647), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 299/410 (72%), Positives = 346/410 (84%), Gaps = 3/410 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LHAIV+EQ  HP+WG YAQRLL+PE  LWRNP
Sbjct: 326 MKVAEELYQAGFISYPRTETDSFSPNTDLHAIVREQADHPDWGTYAQRLLNPEERLWRNP 385

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H+KLYELVVRHFLAC S+PAVGAETTVE+DIA
Sbjct: 386 SNGGHDDKAHPPIHPTKFSTGENNWSPDHKKLYELVVRHFLACCSQPAVGAETTVEVDIA 445

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 446 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 505

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNLGEALVMGYD  EM Y+L
Sbjct: 506 DLLSCMDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLGEALVMGYD--EMGYEL 563

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RSN
Sbjct: 564 WKPYLRAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFARSN 623

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   T EVVR CG C ES+M+LK+  +G FMVGC GFPQCRN VWLPGSV+EAAV
Sbjct: 624 RPI-NETQTTIEVVRPCGACNESEMLLKRRPNGGFMVGCRGFPQCRNVVWLPGSVAEAAV 682

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           T   C  C PGPVY+IQ KF + +IPP+++++HLGC+GGCD++L++LTE+
Sbjct: 683 TQQICPTCVPGPVYKIQFKFNRRDIPPSFDVDHLGCVGGCDDVLKELTEM 732


>K4A5R4_SETIT (tr|K4A5R4) DNA topoisomerase OS=Setaria italica GN=Si034218m.g
           PE=3 SV=1
          Length = 862

 Score =  637 bits (1644), Expect = e-180,   Method: Compositional matrix adjust.
 Identities = 302/416 (72%), Positives = 345/416 (82%), Gaps = 3/416 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LHAIV+EQ  HP WG YA RLL PE  LWRNP
Sbjct: 328 MKVAEELYQAGFISYPRTETDNFSPNTDLHAIVREQVEHPVWGAYAHRLLTPEERLWRNP 387

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H +LYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 388 SNGGHDDKAHPPIHPTKFSRGENNWSPDHNRLYELVVRHFLACCSQPAVGAETTVEIDIA 447

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 448 GEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 507

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKD +TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 508 DLLSCMDKAGIGTDATMHDHIKKLLDRCYATKDENTRFSPTNLGEALVMGYD--EMGYEL 565

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL + L +MKACFL AR+NK KLL+AM  FF RSN
Sbjct: 566 WKPYLRSMMEADMKSVSIGTKSKSQVLESCLQQMKACFLDARVNKAKLLDAMGTFFARSN 625

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E     EVVR C  C+ES+MVLK+ ++G FMVGC  +PQCRN VWLPGS+SEA+V
Sbjct: 626 RPV-NETQNPIEVVRPCAACRESEMVLKQKQNGEFMVGCRSYPQCRNVVWLPGSLSEASV 684

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
           T   C  CTPGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++LTEI   G R
Sbjct: 685 TNQVCPICTPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELTEISRFGSR 740


>C5WWW3_SORBI (tr|C5WWW3) DNA topoisomerase OS=Sorghum bicolor GN=Sb01g046210
           PE=3 SV=1
          Length = 860

 Score =  635 bits (1638), Expect = e-179,   Method: Compositional matrix adjust.
 Identities = 302/416 (72%), Positives = 342/416 (82%), Gaps = 3/416 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LHAIV+EQ  HP WG YAQRLL+PEA LWRNP
Sbjct: 327 MKVAEELYQAGFISYPRTETDNFSPNTDLHAIVREQVNHPVWGAYAQRLLNPEARLWRNP 386

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE  WS +H +LYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 387 SNGGHDDKAHPPIHPTKFSEGERNWSPDHIRLYELVVRHFLACCSQPAVGAETTVEIDIA 446

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRVIL KNYLDVY F++WGG+L+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 447 GEQFNASGRVILAKNYLDVYRFDSWGGTLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 506

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMHDHIKKLLDR YATKD +TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 507 DLLSCMDKAGIGTDATMHDHIKKLLDRCYATKDENTRFSPTNLGEALVMGYD--EMGYEL 564

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL + L +MKACFL AR+NK KLL+AM  FF RSN
Sbjct: 565 WKPYLRSMMEADMKSVSMGTKSKSEVLESCLQQMKACFLDARVNKAKLLDAMGTFFARSN 624

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E     EVVR CG C  S+MVLK+   G FMVGC  +PQCRN VWLPGS+SEAAV
Sbjct: 625 RPI-NETQNPVEVVRPCGACNGSEMVLKRRVTGEFMVGCRSYPQCRNVVWLPGSLSEAAV 683

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
           T   C  C PGPVY+IQ KFR+ +IPPN++++HLGC+GGCD+IL++L E+   G R
Sbjct: 684 TNQVCPICAPGPVYKIQFKFRRRDIPPNFDVDHLGCVGGCDDILKELMELSRFGSR 739


>M0WQP5_HORVD (tr|M0WQP5) DNA topoisomerase OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 918

 Score =  634 bits (1635), Expect = e-179,   Method: Compositional matrix adjust.
 Identities = 299/411 (72%), Positives = 346/411 (84%), Gaps = 4/411 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LHAIV+EQ  HP+WG YAQRLL+PE  LWRNP
Sbjct: 326 MKVAEELYQAGFISYPRTETDSFSPNTDLHAIVREQADHPDWGTYAQRLLNPEERLWRNP 385

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H+KLYELVVRHFLAC S+PAVGAETTVE+DIA
Sbjct: 386 SNGGHDDKAHPPIHPTKFSTGENNWSPDHKKLYELVVRHFLACCSQPAVGAETTVEVDIA 445

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 446 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 505

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNL-GEALVMGYDDIEMAYK 250
           DLLSCMDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNL GEALVMGYD  EM Y+
Sbjct: 506 DLLSCMDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLVGEALVMGYD--EMGYE 563

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           LWKP LR+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RS
Sbjct: 564 LWKPYLRAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFARS 623

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
           NR   +E   T EVVR CG C ES+M+LK+  +G FMVGC GFPQCRN VWLPGSV+EAA
Sbjct: 624 NRPI-NETQTTIEVVRPCGACNESEMLLKRRPNGGFMVGCRGFPQCRNVVWLPGSVAEAA 682

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           VT   C  C PGPVY+IQ KF + +IPP+++++HLGC+GGCD++L++LTE+
Sbjct: 683 VTQQICPTCVPGPVYKIQFKFNRRDIPPSFDVDHLGCVGGCDDVLKELTEM 733


>C7J0A2_ORYSJ (tr|C7J0A2) DNA topoisomerase OS=Oryza sativa subsp. japonica
           GN=Os03g0165000 PE=3 SV=1
          Length = 928

 Score =  632 bits (1630), Expect = e-179,   Method: Compositional matrix adjust.
 Identities = 299/414 (72%), Positives = 339/414 (81%), Gaps = 3/414 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LH+IV EQ  HP WG YAQRLLDPEA LWRNP
Sbjct: 330 MKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNP 389

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 390 SNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIA 449

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQF PT LTLDSG+TRPPPLL+EA
Sbjct: 450 GEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQFVPTTLTLDSGMTRPPPLLAEA 509

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLL CMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 510 DLLGCMDKAGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYD--EMGYEL 567

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF RS+
Sbjct: 568 WKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARSS 627

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   + E VR C  C ES+M LK+   G FMVGC GFPQCRN VWLP S+S AAV
Sbjct: 628 RPV-NETQNSIETVRPCAACNESEMFLKQRPTGEFMVGCRGFPQCRNVVWLPRSLSGAAV 686

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           T   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L E+   G
Sbjct: 687 TDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMELSRFG 740


>I1H9D9_BRADI (tr|I1H9D9) DNA topoisomerase OS=Brachypodium distachyon
           GN=BRADI1G74120 PE=3 SV=1
          Length = 924

 Score =  629 bits (1623), Expect = e-178,   Method: Compositional matrix adjust.
 Identities = 298/410 (72%), Positives = 342/410 (83%), Gaps = 3/410 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LHAI  EQ  HP WG YAQRLL+PE  LWRNP
Sbjct: 329 MKVAEELYQAGFISYPRTETDNFSPNTDLHAIAHEQVPHPVWGSYAQRLLNPEERLWRNP 388

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKF+AGES WSQ+H K+YELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 389 SNGGHDDKAHPPIHPTKFTAGESNWSQDHHKVYELVVRHFLACCSQPAVGAETTVEIDIA 448

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTYT+GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 449 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYTIGQQFVPTTLTLDSGVTRPPPLLAEA 508

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNLGEALVMGYD  EM Y+L
Sbjct: 509 DLLSCMDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLGEALVMGYD--EMGYEL 566

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME+DMK+VS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RSN
Sbjct: 567 WKPYLRAMMEADMKAVSIGTKSKLEVLEGCLQQMKACFLDARSNKVKLLDAMGTFFARSN 626

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E     EVVR CG C +S+M+LK+  +G FMVGC  FPQCRN VWLPGS+SEAAV
Sbjct: 627 RPL-NETQNPMEVVRPCGACNDSEMLLKRKPNGGFMVGCRSFPQCRNVVWLPGSLSEAAV 685

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           T   C  C PGPVY+IQ KF + +IPPN++++HLGCIGGCD++L++L EI
Sbjct: 686 TEQICPTCVPGPVYKIQFKFNRRDIPPNFDVDHLGCIGGCDDVLKELIEI 735


>I1P7W6_ORYGL (tr|I1P7W6) DNA topoisomerase OS=Oryza glaberrima PE=3 SV=1
          Length = 880

 Score =  628 bits (1619), Expect = e-177,   Method: Compositional matrix adjust.
 Identities = 302/431 (70%), Positives = 342/431 (79%), Gaps = 7/431 (1%)

Query: 11  FLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRN 70
            L VAEELYQ GFISYPRTETD+FSP T+LH+IV EQ  HP WG YAQRLLDPEA LWRN
Sbjct: 336 ILFVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRN 395

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           P  GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEIDI
Sbjct: 396 PSNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDI 455

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           A E F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQF PT LTLDSG+TRPPPLL+E
Sbjct: 456 ASEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQFVPTTLTLDSGMTRPPPLLAE 515

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADLL CMDK GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYD  EM Y+
Sbjct: 516 ADLLGCMDKAGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYD--EMGYE 573

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           LWKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF RS
Sbjct: 574 LWKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARS 633

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
           +R   +E   + E VR C  C ES+M LK+   G FMVGC GFPQCRN VWLP S+S AA
Sbjct: 634 SRPV-NETQNSIETVRPCAACNESEMFLKQRPTGEFMVGCRGFPQCRNVVWLPRSLSGAA 692

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR--- 427
           VT   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L E+   G     
Sbjct: 693 VTDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMELSRFGSHSQT 752

Query: 428 -MPGLYERLSC 437
             PG  +  SC
Sbjct: 753 ATPGQVQCTSC 763


>A9U3P7_PHYPA (tr|A9U3P7) DNA topoisomerase OS=Physcomitrella patens subsp.
           patens GN=PHYPADRAFT_155610 PE=3 SV=1
          Length = 915

 Score =  562 bits (1448), Expect = e-157,   Method: Compositional matrix adjust.
 Identities = 268/416 (64%), Positives = 318/416 (76%), Gaps = 5/416 (1%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           +FL+VAEELYQ GFISYPRTETD FS   +L +IV EQ GH  WG YAQRLLDP+  LW+
Sbjct: 329 QFLQVAEELYQAGFISYPRTETDKFSENQDLQSIVNEQIGHSAWGQYAQRLLDPQQQLWK 388

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            P  GGHDDKAHPPIHPT+FS GE  W+ +H ++YELVVRHFLACVS+PA+G  TT  ID
Sbjct: 389 QPGDGGHDDKAHPPIHPTRFSEGEGNWTNDHARIYELVVRHFLACVSQPAIGYGTTATID 448

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE F+A G +I  KNYLDVY F+ WG S IP + VGQQF PT LTL+ G T+PPPLLS
Sbjct: 449 IAGERFTATGLMITAKNYLDVYRFDNWGTSTIPKFEVGQQFIPTRLTLEVGRTQPPPLLS 508

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EADL+S MDK GIGTDATMHDHIKKLLDR YATKDA+TRF PT LGEALVMGYD   M +
Sbjct: 509 EADLISLMDKAGIGTDATMHDHIKKLLDRCYATKDANTRFCPTTLGEALVMGYD--SMGH 566

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
           +LWKP+LR+ MESDMK+VS+G K K  VL  +L+ MK+ F+ AR  K KLL+AM IFF+R
Sbjct: 567 ELWKPDLRALMESDMKAVSDGRKTKPQVLEAALEGMKSLFISARTQKEKLLDAMGIFFER 626

Query: 310 SNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
           S  + GDE    GE VR C LCQ++ M+L+K  DG FMVGC G+P CRN VWLPG   EA
Sbjct: 627 S--AGGDEQRQAGERVRLCPLCQQNTMILRKKPDGKFMVGCSGYPNCRNVVWLPGPAIEA 684

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           +VT  PC  C PG V +I LKFR+ EIPPN+++ H GC+ GCD ++++L EICGT 
Sbjct: 685 SVTNQPCISCGPGQVLKIYLKFRRGEIPPNFDVEHTGCV-GCDRVIKELIEICGTA 739


>N1R4S4_AEGTA (tr|N1R4S4) DNA topoisomerase 3-alpha OS=Aegilops tauschii
           GN=F775_23159 PE=4 SV=1
          Length = 745

 Score =  556 bits (1434), Expect = e-156,   Method: Compositional matrix adjust.
 Identities = 268/410 (65%), Positives = 314/410 (76%), Gaps = 38/410 (9%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LHAIV+EQ  HP+WG YAQRLL+PE  LWRNP
Sbjct: 295 MKVAEELYQAGFISYPRTETDSFSPNTDLHAIVREQVDHPDWGTYAQRLLNPEERLWRNP 354

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H+K+YELVVRHFLAC S+PAVGAETTVE+DIA
Sbjct: 355 SNGGHDDKAHPPIHPTKFSTGENNWSPDHKKVYELVVRHFLACCSQPAVGAETTVEVDIA 414

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTYT+GQ F PT+LTLDSGVTRPPPLL+EA
Sbjct: 415 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYTIGQTFVPTSLTLDSGVTRPPPLLAEA 474

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK                                   GEALVMGYD  EM Y+L
Sbjct: 475 DLLSCMDK-----------------------------------GEALVMGYD--EMGYEL 497

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LR+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RSN
Sbjct: 498 WKPYLRAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFARSN 557

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   T EVVR CG C +S+M+LK+  +G FMVGC GFPQCRN VWLPGS++EAAV
Sbjct: 558 RPI-NETQNTIEVVRPCGACNDSEMLLKRRPNGGFMVGCRGFPQCRNVVWLPGSLAEAAV 616

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           T   C  C PGPVY+IQ KF + +IPP+++++HLGCIGGCD++L++LTE+
Sbjct: 617 TQQICPTCVPGPVYKIQFKFNRRDIPPSFDVDHLGCIGGCDDVLKELTEM 666


>B8BDG8_ORYSI (tr|B8BDG8) DNA topoisomerase OS=Oryza sativa subsp. indica
           GN=OsI_30540 PE=3 SV=1
          Length = 897

 Score =  555 bits (1429), Expect = e-155,   Method: Compositional matrix adjust.
 Identities = 271/414 (65%), Positives = 311/414 (75%), Gaps = 34/414 (8%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP  +LH+IV EQ  HP  GIYAQRLLDPEA LWRNP
Sbjct: 330 MKVAEELYQAGFISYPRTETDNFSPNIDLHSIVHEQVAHPNRGIYAQRLLDPEARLWRNP 389

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEI+IA
Sbjct: 390 SNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEINIA 449

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQ                      
Sbjct: 450 GEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQ---------------------- 487

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
                    GIGTDATMHDHIKKLLDR YATK+A+TRF+PTNLGEALVMGY+  EM Y+L
Sbjct: 488 --------AGIGTDATMHDHIKKLLDRCYATKNANTRFSPTNLGEALVMGYN--EMGYEL 537

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS  TK K  VL   L +MKACFL AR NKVKL +AM  FF RS+
Sbjct: 538 WKPYLRSVMEADMKSVSICTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARSS 597

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +  +   E VR C  C ES+M LK+   G FMVGC GFPQCRNAVWLP S+SEAAV
Sbjct: 598 RPVNETQNV--ETVRPCAACNESEMFLKQRPTGEFMVGCRGFPQCRNAVWLPRSLSEAAV 655

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           T   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L EI   G
Sbjct: 656 TDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMEISRFG 709


>D8RIM2_SELML (tr|D8RIM2) DNA topoisomerase OS=Selaginella moellendorffii
           GN=SELMODRAFT_94303 PE=3 SV=1
          Length = 794

 Score =  534 bits (1375), Expect = e-149,   Method: Compositional matrix adjust.
 Identities = 257/425 (60%), Positives = 303/425 (71%), Gaps = 8/425 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AEELYQ GFISYPRTETD FS  T+L  +V+EQ  HP WG YA RL+DP   LWR+P
Sbjct: 320 MKAAEELYQQGFISYPRTETDYFSENTDLRRMVEEQTRHPVWGNYAHRLVDPRENLWRHP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPT+FS GE  W  +H+ +YELVVRHFLACVS+PAVG  T   IDIA
Sbjct: 380 SNGGHDDKAHPPIHPTRFSDGEPQWRNDHKAVYELVVRHFLACVSQPAVGYATKAMIDIA 439

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA G ++  +NYL+VY +E W  S +P + +GQQF PT LTLD+G T+PPPLLSEA
Sbjct: 440 GEQFSANGLMVTARNYLEVYRYENWAASTLPNFDLGQQFIPTRLTLDAGRTQPPPLLSEA 499

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDKEGIGTDATMHDHIKKLLDR YATKDA TRF PTNLGEALVMGYD   M Y+L
Sbjct: 500 DLIALMDKEGIGTDATMHDHIKKLLDRRYATKDAQTRFCPTNLGEALVMGYD--TMGYEL 557

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR----LNKVKLLEAMSIFF 307
           WKP LRS ME DMK+VS+G K K+ VL T L +MK CFL  +    L    +   +S + 
Sbjct: 558 WKPHLRSIMERDMKAVSDGIKVKENVLETCLQQMKTCFLDRQWVFSLRGKHVFFGISFYL 617

Query: 308 QRSNRSAGD--ELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGS 365
            RSNRS     E    G +VRRC +C+E+DMVLK+  D  FMVGC  FPQC+N VWLP  
Sbjct: 618 DRSNRSQNQVPEAVQVGGIVRRCPMCREADMVLKRRPDSKFMVGCRNFPQCKNVVWLPSV 677

Query: 366 VSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           V EA VT + CN C P PVY+I  KF++ EIPP Y+I H GC+GGCD +L  +  I    
Sbjct: 678 VMEATVTAHTCNSCIPAPVYKIDFKFKRAEIPPQYSIYHTGCVGGCDIVLNDIMNIYRAP 737

Query: 426 PRMPG 430
           P   G
Sbjct: 738 PAPSG 742


>Q8S5U5_ORYSJ (tr|Q8S5U5) DNA topoisomerase OS=Oryza sativa subsp. japonica
           GN=OJ1123F12.5 PE=3 SV=1
          Length = 912

 Score =  534 bits (1375), Expect = e-149,   Method: Compositional matrix adjust.
 Identities = 264/414 (63%), Positives = 302/414 (72%), Gaps = 46/414 (11%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LH+IV EQ  HP WG YAQRLLDPEA LWRNP
Sbjct: 428 MKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNP 487

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 488 SNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIA 547

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQ                      
Sbjct: 548 GEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQ---------------------- 585

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
                    GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 586 --------AGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYD--EMGYEL 635

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF RS+
Sbjct: 636 WKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARSS 695

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   + E VR C  C ES+M LK+               CRN VWLP S+S AAV
Sbjct: 696 RPV-NETQNSIETVRPCAACNESEMFLKQR-------------PCRNVVWLPRSLSGAAV 741

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           T   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L E+   G
Sbjct: 742 TDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMELSRFG 795


>B9FBH7_ORYSJ (tr|B9FBH7) DNA topoisomerase OS=Oryza sativa subsp. japonica
           GN=OsJ_09535 PE=3 SV=1
          Length = 983

 Score =  533 bits (1374), Expect = e-149,   Method: Compositional matrix adjust.
 Identities = 264/414 (63%), Positives = 302/414 (72%), Gaps = 46/414 (11%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LH+IV EQ  HP WG YAQRLLDPEA LWRNP
Sbjct: 428 MKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNP 487

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 488 SNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIA 547

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQ                      
Sbjct: 548 GEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQ---------------------- 585

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
                    GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 586 --------AGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYD--EMGYEL 635

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF RS+
Sbjct: 636 WKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARSS 695

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   + E VR C  C ES+M LK+               CRN VWLP S+S AAV
Sbjct: 696 RPV-NETQNSIETVRPCAACNESEMFLKQR-------------PCRNVVWLPRSLSGAAV 741

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           T   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L E+   G
Sbjct: 742 TDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMELSRFG 795


>B8ANX5_ORYSI (tr|B8ANX5) DNA topoisomerase OS=Oryza sativa subsp. indica
           GN=OsI_10148 PE=3 SV=1
          Length = 981

 Score =  533 bits (1373), Expect = e-149,   Method: Compositional matrix adjust.
 Identities = 264/414 (63%), Positives = 302/414 (72%), Gaps = 46/414 (11%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP T+LH+IV EQ  HP WG YAQRLLDPEA LWRNP
Sbjct: 428 MKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNP 487

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEIDIA
Sbjct: 488 SNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIA 547

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY F++WGG+L+PTY +GQQ                      
Sbjct: 548 GEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQ---------------------- 585

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
                    GIGTDATMHDHIKKLLDR YATKDA+TRF+PTNLGEALVMGYD  EM Y+L
Sbjct: 586 --------AGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYD--EMGYEL 635

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF RS+
Sbjct: 636 WKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARSS 695

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           R   +E   + E VR C  C ES+M LK+               CRN VWLP S+S AAV
Sbjct: 696 RPV-NETQNSIETVRPCAACNESEMFLKQR-------------PCRNVVWLPRSLSGAAV 741

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           T   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L E+   G
Sbjct: 742 TDQVCPTCAPGPVYKIQSKFRRRDIPPNFDVDHLGCIGGCDDILKELMELSRFG 795


>D8SP39_SELML (tr|D8SP39) DNA topoisomerase OS=Selaginella moellendorffii
           GN=SELMODRAFT_121488 PE=3 SV=1
          Length = 791

 Score =  521 bits (1341), Expect = e-145,   Method: Compositional matrix adjust.
 Identities = 254/422 (60%), Positives = 300/422 (71%), Gaps = 5/422 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AEELYQ GFISYPRTETD FS  T+L  +V+EQ  HP WG YA RLLD    LWR+P
Sbjct: 320 MKAAEELYQQGFISYPRTETDYFSENTDLRRMVEEQTRHPVWGNYAHRLLDSRENLWRHP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPT+FS GE  W  +H+ +YELVVRHFLACVS+PAVG  T   IDIA
Sbjct: 380 SNGGHDDKAHPPIHPTRFSDGEPQWRNDHKAVYELVVRHFLACVSQPAVGYATKAMIDIA 439

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FSA G ++  +NYL+VY +E W  S +P + +GQQF PT LTLD+G T+PPPLLSEA
Sbjct: 440 GEQFSANGLMVTARNYLEVYRYENWAASTLPNFDLGQQFIPTRLTLDAGRTQPPPLLSEA 499

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDKEGIGTDATMHDHIKKLLDR YATKDA TRF PTNLGEALVMGYD   M Y+L
Sbjct: 500 DLIALMDKEGIGTDATMHDHIKKLLDRRYATKDAQTRFCPTNLGEALVMGYDT--MGYEL 557

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
           WKP LRS ME DMK+V +G K K+ VL T L +MK CFL       +LL    IF   S 
Sbjct: 558 WKPHLRSIMERDMKAVGDGIKVKENVLETCLQQMKTCFLDVGFKAFQLLLYFLIFLIFSR 617

Query: 312 RSAGDELH---ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
             + +++      G +VRRC +C+E+DMVLK+  D  FMVGC  FPQC+N VWLP  V E
Sbjct: 618 LESQNQVPEAVQVGGIVRRCPMCREADMVLKRRPDSKFMVGCRNFPQCKNVVWLPSVVME 677

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPRM 428
           A VTT+ CN C P PVY+I  KF++ EIPP Y+I H GC+GGCD +L  +  I    P  
Sbjct: 678 ATVTTHTCNSCIPAPVYKIDFKFKRAEIPPQYSIYHTGCVGGCDIVLNDIMNIYRAPPAP 737

Query: 429 PG 430
            G
Sbjct: 738 SG 739


>M0WQP2_HORVD (tr|M0WQP2) DNA topoisomerase OS=Hordeum vulgare var. distichum
           PE=3 SV=1
          Length = 626

 Score =  488 bits (1256), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 231/298 (77%), Positives = 258/298 (86%), Gaps = 2/298 (0%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFSP T+LHAIV+EQ  HP+WG YAQRLL+PE  LWRNP
Sbjct: 326 MKVAEELYQAGFISYPRTETDSFSPNTDLHAIVREQADHPDWGTYAQRLLNPEERLWRNP 385

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFS GE+ WS +H+KLYELVVRHFLAC S+PAVGAETTVE+DIA
Sbjct: 386 SNGGHDDKAHPPIHPTKFSTGENNWSPDHKKLYELVVRHFLACCSQPAVGAETTVEVDIA 445

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A GRV+L KNYLDVY +++WGGSL+PTY +GQQF PT LTLDSGVTRPPPLL+EA
Sbjct: 446 GEQFNASGRVVLAKNYLDVYRYDSWGGSLLPTYNIGQQFVPTTLTLDSGVTRPPPLLAEA 505

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DLLSCMDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNLGEALVMGYD  EM Y+L
Sbjct: 506 DLLSCMDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLGEALVMGYD--EMGYEL 563

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
           WKP LR+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF R
Sbjct: 564 WKPYLRAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFAR 621


>M5WY32_PRUPE (tr|M5WY32) Uncharacterized protein (Fragment) OS=Prunus persica
           GN=PRUPE_ppa020488mg PE=4 SV=1
          Length = 542

 Score =  422 bits (1086), Expect = e-115,   Method: Compositional matrix adjust.
 Identities = 197/223 (88%), Positives = 208/223 (93%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETDSFS RTNLHAIVQEQQGHP WG YAQRLLDP +GLWRNP
Sbjct: 320 MKVAEELYQAGFISYPRTETDSFSERTNLHAIVQEQQGHPGWGSYAQRLLDPASGLWRNP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R GGHDDKAHPPIHPTKFS+GESGWSQ+H +LYELVVRHFLACVS+PAVGAETTVEIDIA
Sbjct: 380 RNGGHDDKAHPPIHPTKFSSGESGWSQDHHRLYELVVRHFLACVSQPAVGAETTVEIDIA 439

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GELF A GRVI+ KNYLDVY FE+WGGSL+PTY VGQQF PT LTLDSGVTRPPPLLSEA
Sbjct: 440 GELFFASGRVIVAKNYLDVYRFESWGGSLLPTYEVGQQFVPTTLTLDSGVTRPPPLLSEA 499

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNL 234
           DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD+S RF+PTNL
Sbjct: 500 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDSSMRFSPTNL 542


>G7JC55_MEDTR (tr|G7JC55) DNA topoisomerase OS=Medicago truncatula
           GN=MTR_3g096640 PE=3 SV=1
          Length = 587

 Score =  414 bits (1063), Expect = e-113,   Method: Compositional matrix adjust.
 Identities = 201/261 (77%), Positives = 217/261 (83%), Gaps = 25/261 (9%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +KVAEELYQ GFISYPRTETD+FS RT+LHAIVQEQQGHPEWGIYAQRLLDP AGLWR
Sbjct: 323 RTMKVAEELYQGGFISYPRTETDNFSSRTDLHAIVQEQQGHPEWGIYAQRLLDPGAGLWR 382

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           NPRGGGHDD+AHPPIHPTKFSAGESGWSQ+HRKLYELVVRHFLACVSKPA+GAETTVEID
Sbjct: 383 NPRGGGHDDQAHPPIHPTKFSAGESGWSQDHRKLYELVVRHFLACVSKPALGAETTVEID 442

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQ--------------------- 168
           IAGE FSACGRVILE+NYLD+Y ++ W GS+IP Y +G+                     
Sbjct: 443 IAGERFSACGRVILERNYLDIYIYDRWDGSMIPNYAIGEQYPKSQIPDGILHQTNPGIPE 502

Query: 169 ----QFTPTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD 224
               QF PT LTLD G T PPPLLSEADLLS MDKE IGTDATMHDHIKKLLDRFYATKD
Sbjct: 503 LLLLQFIPTTLTLDPGKTNPPPLLSEADLLSRMDKECIGTDATMHDHIKKLLDRFYATKD 562

Query: 225 ASTRFTPTNLGEALVMGYDDI 245
           A+  FTPTNLGEALVMGYDD+
Sbjct: 563 ANMCFTPTNLGEALVMGYDDM 583


>Q5NCT0_MOUSE (tr|Q5NCT0) DNA topoisomerase 3-alpha OS=Mus musculus GN=Top3a PE=2
           SV=2
          Length = 773

 Score =  379 bits (973), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 190/409 (46%), Positives = 265/409 (64%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 323 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++G  G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 380 RNGSKSDQAHPPIHPTKYTSGLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIA 436

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 437 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 496

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 497 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 554

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 555 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 614

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR+AVW P SV EA
Sbjct: 615 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEA 673

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 674 SRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEI 722


>Q8CDI8_MOUSE (tr|Q8CDI8) DNA topoisomerase (Fragment) OS=Mus musculus GN=Top3a
           PE=2 SV=1
          Length = 839

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 190/409 (46%), Positives = 265/409 (64%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 233 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 289

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++G  G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 290 RNGSKSDQAHPPIHPTKYTSGLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIA 346

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 347 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 406

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 407 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 464

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 465 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 524

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR+AVW P SV EA
Sbjct: 525 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEA 583

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 584 SRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEI 632


>Q5NCT2_MOUSE (tr|Q5NCT2) Topoisomerase (DNA) III alpha OS=Mus musculus GN=Top3a
           PE=2 SV=1
          Length = 1003

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 190/409 (46%), Positives = 265/409 (64%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++G  G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGSKSDQAHPPIHPTKYTSGLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 639

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR+AVW P SV EA
Sbjct: 640 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 699 SRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEI 747


>Q3V3P1_MOUSE (tr|Q3V3P1) DNA topoisomerase OS=Mus musculus GN=Top3a PE=2 SV=1
          Length = 954

 Score =  377 bits (969), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 190/409 (46%), Positives = 265/409 (64%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++G  G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGSKSDQAHPPIHPTKYTSGLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 639

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR+AVW P SV EA
Sbjct: 640 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 699 SRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEI 747


>Q3TBE3_MOUSE (tr|Q3TBE3) DNA topoisomerase OS=Mus musculus GN=Top3a PE=2 SV=1
          Length = 773

 Score =  376 bits (966), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 189/409 (46%), Positives = 264/409 (64%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 323 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 380 RNGSKSDQAHPPIHPTKYTSSLQG---DDRRLYEFIVRHFLACCSQGAQGQETTVEIDIA 436

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 437 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 496

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 497 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 554

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 555 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 614

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR+AVW P SV EA
Sbjct: 615 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEA 673

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 674 SRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEI 722


>L8YCR4_TUPCH (tr|L8YCR4) DNA topoisomerase OS=Tupaia chinensis
           GN=TREES_T100005658 PE=3 SV=1
          Length = 967

 Score =  375 bits (963), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 191/412 (46%), Positives = 264/412 (64%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL A+V +Q   P WG +A+ +L+       NP
Sbjct: 328 MRIAEKLYTQGFISYPRTETNIFPKDLNLTALVDQQTQDPRWGAFARSILERGGP---NP 384

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 385 RNGNKSDQAHPPIHPTKYASNLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 441

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   L+P Y  G +F P+A+ +  G T PP LL+EA
Sbjct: 442 QERFVAHGLVILARNYLDVYPYDHWSDKLLPVYERGSRFQPSAVEMVDGETSPPQLLTEA 501

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 502 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 559

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F  A     KL EA+S +F +R+
Sbjct: 560 SKPDLRAELEADLKLICEGKKDKHVVLRQQVQKYKQVFTEAVAKAKKLDEALSQYFGERA 619

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                +E++ A  E +R+C  C + DMVL+  + G F + C GFP+CR+AVW P SV EA
Sbjct: 620 EVVQQEEMYPAMPEPIRKCPQCNK-DMVLRTKKTGGFYLSCTGFPECRSAVWFPDSVLEA 678

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 679 SRDGSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLREILDL 730


>Q6GPC0_XENLA (tr|Q6GPC0) DNA topoisomerase OS=Xenopus laevis GN=top3a PE=2 SV=1
          Length = 1022

 Score =  374 bits (959), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 189/412 (45%), Positives = 262/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE+LY  GFISYPRTET+ F    NL ++V++Q   P+WG +AQR+L+        P
Sbjct: 353 MKTAEKLYTQGFISYPRTETNIFPKDLNLTSLVEQQTHDPQWGGFAQRILERGGP---TP 409

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N +++YE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 410 RNGNKTDQAHPPIHPTKYTNNLQG---NEQRIYEFIVRHFLACCSQDAQGQETTVEIDIA 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +I+ +NYLDVYP++ W   +IP Y +G QF PT + +  G T PP LL+EA
Sbjct: 467 AERFVAHGLMIIARNYLDVYPYDKWNTKIIPVYEMGAQFQPTTVEMVDGETSPPQLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M +++
Sbjct: 527 DLIALMEKHGIGTDATHAEHIETIKSRSYVGLTPEQRFLPGELGMGLVEGYDS--MGFQM 584

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +ESD+K + EG K K  VL   + K K  F+ A     KL EA+S +F Q +
Sbjct: 585 SKPDLRAELESDLKLICEGKKDKFTVLRLQIQKYKQVFVEAAAKATKLDEALSQYFGQAA 644

Query: 311 NRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                 E++A   + VR+C  C   DMVLK  RDG F + C+G+P C+++VW P SV E 
Sbjct: 645 EAVPQQEIYAETPLPVRKCPQCNR-DMVLKTKRDGGFFLSCVGYPSCKSSVWFPSSVLEV 703

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C+ C P PV++++LKF++  IPP   +  +GCIGGCDE LR++ ++
Sbjct: 704 SRDESICSTCRPHPVHKLKLKFKRGSIPPLMPLEFVGCIGGCDETLREILDL 755


>R0JZT4_ANAPL (tr|R0JZT4) DNA topoisomerase 3-alpha (Fragment) OS=Anas
           platyrhynchos GN=Anapl_13460 PE=4 SV=1
          Length = 1020

 Score =  373 bits (958), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 193/412 (46%), Positives = 262/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    NL A+VQ+Q   P WG +AQR+LD + G    P
Sbjct: 350 MKIAEKLYTQGFISYPRTETNIFPKELNLSALVQQQTQDPNWGAFAQRILD-QGG--PTP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++A   G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RSGTKSDQAHPPIHPTKYTANLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYL+VYP+E W   +IP Y  G +F PT + +  G T PP LLSEA
Sbjct: 464 NERFIAQGLMILARNYLEVYPYEKWSDKVIPVYQKGSRFQPTTVEMVDGETSPPLLLSEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL +A++ +F  + 
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKSVVLQQQVQKYKQVFIEAVARANKLDQALAQYFGEAT 641

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  + +R+C  C  +DMVLK  R+G F + C+G+P C+ AVW P  V + 
Sbjct: 642 EIAEQEEVYPAMPDPIRKCPQCN-NDMVLKTKRNGGFYLSCMGYPACKTAVWFPDFVLDV 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           A   + C  C P PV+R++ KF++  +PP   +  +GCIGGCDE+LR+L ++
Sbjct: 701 AKDESICAECGPHPVHRLKFKFKRGSVPPVMPLEFVGCIGGCDEMLRELLDL 752


>M7BIP5_CHEMY (tr|M7BIP5) DNA topoisomerase 3-alpha OS=Chelonia mydas
           GN=UY3_07306 PE=4 SV=1
          Length = 906

 Score =  372 bits (954), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 187/412 (45%), Positives = 262/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F    NL ++VQ+Q   P WG +AQR+LD        P
Sbjct: 237 MKIAEKLYTQGYISYPRTETNIFPKDLNLTSLVQQQTQDPSWGAFAQRILDRGGP---TP 293

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 294 RNGTKSDQAHPPIHPTKYTCNLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 350

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP+E W   ++P Y  G +F PT + +  G T PP LL+EA
Sbjct: 351 NERFVAHGLMILARNYLDVYPYEKWSDKVLPVYERGSRFQPTTVEMVDGETSPPQLLTEA 410

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 411 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTPDQRFLPGHLGMGLVEGYDS--MGYEM 468

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   ++K +  F  A     KL +A+S +F + +
Sbjct: 469 SKPDLRAELEADLKLICEGKKDKFVVLRQQIEKYQKVFTEAVAKANKLDQALSQYFGEVT 528

Query: 311 NRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++    V +R+C  C  SDMVLK  ++G F +GC+ +P C+ AVW P SV E 
Sbjct: 529 ALAQQEEIYPAMPVSIRKCPQCN-SDMVLKSKKNGGFYLGCMNYPNCKAAVWFPESVLEV 587

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PV+R++ KF++  +PP   +  +GCIGGCDE+LR++ ++
Sbjct: 588 SKDDSVCAVCKPHPVHRLKFKFKRGSVPPLLPLEFVGCIGGCDEMLREILDL 639


>L5KY49_PTEAL (tr|L5KY49) DNA topoisomerase OS=Pteropus alecto
           GN=PAL_GLEAN10008620 PE=3 SV=1
          Length = 1007

 Score =  371 bits (953), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 192/412 (46%), Positives = 259/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L  E G+   P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTALVEQQIPDPRWGAFAQSIL--ERGV-PTP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G  Q   +LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTSSLQGEEQ---RLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W    +P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLVILARNYLDVYPYDRWSDKTLPVYERGSRFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARTYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F  A     KL EA+S +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFVVLRQQVQKYKQVFTEAVAKAKKLDEALSQYFGEGA 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  + G F + C+GFP+CR+AVW P SV EA
Sbjct: 640 EVAQQEAIYPAVPEPIRKCPQCNK-DMVLKTKKSGGFYLSCVGFPECRSAVWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 699 SRDESVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLREILDL 750


>I3MP50_SPETR (tr|I3MP50) DNA topoisomerase OS=Spermophilus tridecemlineatus
           GN=TOP3A PE=3 SV=1
          Length = 1008

 Score =  371 bits (952), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 186/409 (45%), Positives = 263/409 (64%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLMALVEQQTPDPHWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTSNLQG---DERRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDHWSDKLLPVYEQGSRFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F + +
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGA 639

Query: 311 NRSAGDELHAT-GEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ T  E +++C  C   DMVLK  + G F + C GFP+CR+A+W P SV EA
Sbjct: 640 EVAQQEEIYPTMPEPIQKCPQCNR-DMVLKTKKSGGFYLSCTGFPECRSAIWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 699 SRDGSVCSVCQPPPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLKEI 747


>I3JP28_ORENI (tr|I3JP28) DNA topoisomerase (Fragment) OS=Oreochromis niloticus
           GN=top3a PE=3 SV=1
          Length = 1005

 Score =  371 bits (952), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 192/413 (46%), Positives = 260/413 (62%), Gaps = 11/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F P   L  +V++Q   P WG +AQR+LD   G   NP
Sbjct: 347 MKIAEKLYTQGFISYPRTETNIFPPNLALTPLVEQQTHSPVWGAFAQRVLDQPGG--PNP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G + D+AHPPIHPTKF+    G   N  ++YE +VRHFLACVS+ A+G ET V+IDIA
Sbjct: 405 RQGKNSDQAHPPIHPTKFTNALQG---NEGRVYEFIVRHFLACVSQDALGQETVVDIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G +I+ +NYLDVYP++ W   +IP Y  G QF P+A+ +  G T PP LL+EA
Sbjct: 462 QEKFSASGLMIIARNYLDVYPYDRWSTKVIPVYEQGSQFQPSAIEMVDGQTSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RFTP  LG  LV GY+   M Y++
Sbjct: 522 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFTPGELGMGLVEGYNS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K K  F+ +     KL EA+S +   ++
Sbjct: 580 SKPNLRAELEADLKLVSEGQKDKQSVLQHHIQKYKTVFIESVRKAKKLDEALSPYLGAAH 639

Query: 312 R--SAGDELHATGEVVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSE 368
               A  +       VR+C  C   DMVLKK R+GN   + C+GFP C+ AVW P  V E
Sbjct: 640 EIPEAEQQDMEIPLPVRKCPNCGR-DMVLKKKREGNGKYLSCVGFPACKTAVWFPDVVLE 698

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            +   + C  C P P++ ++ KFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 699 VSRDESICPTCQPHPIHMLKFKFRRGSLPPMMPLEFVGCIGGCDETLREVLDL 751


>H3AKB8_LATCH (tr|H3AKB8) DNA topoisomerase OS=Latimeria chalumnae PE=3 SV=1
          Length = 999

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 186/412 (45%), Positives = 258/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F P  NL ++VQ+Q G   WG +AQ +LD        P
Sbjct: 342 MKIAEKLYTQGYISYPRTETNMFPPDLNLSSLVQQQTGDQRWGAFAQGILDRGGP---TP 398

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ET VEIDIA
Sbjct: 399 RSGNKSDQAHPPIHPTKYTNALQG---NEQRLYEFIVRHFLACCSQDAQGQETIVEIDIA 455

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +I+ +NYLDVYP++ W   +IP Y +G +F PT + +  G T PP LL+EA
Sbjct: 456 KERFVAHGLMIIARNYLDVYPYDKWNAKVIPVYEMGSRFQPTTIEMLDGETSPPQLLTEA 515

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y++
Sbjct: 516 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTPEQRFLPGELGMGLVEGYDS--MGYEM 573

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K +SEG K K  VL   + K K  F+ A     KL EA+S++F + S
Sbjct: 574 SKPDLRAELEADLKLISEGKKDKFTVLRQHVQKYKQVFVEAVAKAKKLDEALSLYFGEAS 633

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E+       VR+C  C   DM+LK  +DG F + C+G+P C+ AVW P SV E 
Sbjct: 634 QVTQIEEMQMEIPRPVRKCPQCNR-DMILKTKKDGGFYLSCMGYPSCKTAVWFPSSVLEV 692

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           ++  + C  C P PV+ ++ KF++  +P    +  +GCIGGCDE LR++ ++
Sbjct: 693 SIDDSVCPTCKPHPVHGLKFKFKRGSLPATMPLEFVGCIGGCDETLREVLDL 744


>I3JP29_ORENI (tr|I3JP29) DNA topoisomerase OS=Oreochromis niloticus GN=top3a
           PE=3 SV=1
          Length = 1037

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 192/413 (46%), Positives = 260/413 (62%), Gaps = 11/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F P   L  +V++Q   P WG +AQR+LD   G   NP
Sbjct: 365 MKIAEKLYTQGFISYPRTETNIFPPNLALTPLVEQQTHSPVWGAFAQRVLDQPGG--PNP 422

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G + D+AHPPIHPTKF+    G   N  ++YE +VRHFLACVS+ A+G ET V+IDIA
Sbjct: 423 RQGKNSDQAHPPIHPTKFTNALQG---NEGRVYEFIVRHFLACVSQDALGQETVVDIDIA 479

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G +I+ +NYLDVYP++ W   +IP Y  G QF P+A+ +  G T PP LL+EA
Sbjct: 480 QEKFSASGLMIIARNYLDVYPYDRWSTKVIPVYEQGSQFQPSAIEMVDGQTSPPQLLTEA 539

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RFTP  LG  LV GY+   M Y++
Sbjct: 540 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFTPGELGMGLVEGYNS--MGYEM 597

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K K  F+ +     KL EA+S +   ++
Sbjct: 598 SKPNLRAELEADLKLVSEGQKDKQSVLQHHIQKYKTVFIESVRKAKKLDEALSPYLGAAH 657

Query: 312 R--SAGDELHATGEVVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSE 368
               A  +       VR+C  C   DMVLKK R+GN   + C+GFP C+ AVW P  V E
Sbjct: 658 EIPEAEQQDMEIPLPVRKCPNCGR-DMVLKKKREGNGKYLSCVGFPACKTAVWFPDVVLE 716

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            +   + C  C P P++ ++ KFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 717 VSRDESICPTCQPHPIHMLKFKFRRGSLPPMMPLEFVGCIGGCDETLREVLDL 769


>H9GF12_ANOCA (tr|H9GF12) DNA topoisomerase OS=Anolis carolinensis GN=TOP3A PE=3
           SV=2
          Length = 997

 Score =  370 bits (951), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 192/412 (46%), Positives = 262/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F    NL  +VQ Q   P WG +AQR+LD + G    P
Sbjct: 352 MKIAEKLYTQGYISYPRTETNIFPKDLNLPNLVQLQTLDPRWGAFAQRILD-QGGP--TP 408

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +    G   N ++LYE +VRHFLAC S+ A G ETTVEID+A
Sbjct: 409 RSGTKSDQAHPPIHPTKHATNLQG---NDQRLYEFIVRHFLACCSQDAKGQETTVEIDVA 465

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYL+VYP+E W   +IP Y  G +F P+ + +  G T PP LL+EA
Sbjct: 466 NERFVAHGLMILARNYLEVYPYEKWSDKVIPVYEKGSRFQPSTVEMVEGETSPPQLLTEA 525

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y++
Sbjct: 526 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTPDQRFVPGELGMGLVEGYDS--MGYEM 583

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E D+K + EG KGK  VL   + K K  F+ A     KL EA++ +F Q +
Sbjct: 584 SKPDLRAELEHDLKLICEGKKGKAVVLREQVQKYKRVFIEAVQKAKKLDEALAQYFGQGA 643

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  + VR+C  C  SDMVLK  + G F + CLG+P C++AVW P SV E 
Sbjct: 644 PLTQEEEIYPALPDPVRKCPQCN-SDMVLKTKKSGGFYLSCLGYPSCKSAVWFPDSVLEV 702

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C+ C P PV+R++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 703 SKDDSVCDVCRPHPVHRLKLKFKRGGLPPMMPLEFVGCIGGCDETLREVLDL 754


>G1SQY7_RABIT (tr|G1SQY7) DNA topoisomerase OS=Oryctolagus cuniculus PE=3 SV=1
          Length = 993

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 187/412 (45%), Positives = 262/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+       +P
Sbjct: 349 MRIAEKLYTQGYISYPRTETNIFPKDLNLTALVEQQTQDPRWGAFAQSILERGGP---SP 405

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEI+IA
Sbjct: 406 RNGNKSDQAHPPIHPTKYASSLQG---DDQRLYEFIVRHFLACCSQDAQGQETTVEINIA 462

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   L+P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 463 QERFVAHGLVILARNYLDVYPYDHWSDKLLPIYEQGSRFQPSTVEMVDGETSPPQLLTEA 522

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 523 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 580

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 581 SKPDLRAELEADLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGT 640

Query: 312 RSA-GDELHAT-GEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  +EL+ +  E +R+C  C + DMVLK  + G F + C GFP+CR+AVW P SV EA
Sbjct: 641 EVAQQEELYPSLPEPIRKCPQCHK-DMVLKAKKHGGFYLSCTGFPECRSAVWFPDSVLEA 699

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++ KF++  +PP   +  +GC+GGCDE LR++ ++
Sbjct: 700 SRDESVCPVCQPHPVYRVKFKFKRGSLPPTMPLEFVGCVGGCDETLREILDL 751


>G3SN49_LOXAF (tr|G3SN49) DNA topoisomerase OS=Loxodonta africana GN=TOP3A PE=3
           SV=1
          Length = 1008

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 188/412 (45%), Positives = 261/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 350 MRIAERLYTQGYISYPRTETNIFPKDLNLTALVEQQIQDPRWGAFAQSILERGGP---TP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK ++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGNKSDQAHPPIHPTKHTSNLQG---DEQRLYEFIVRHFLACCSQNAQGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G ++L +NYLDVYP++ W   +IP Y  G  F P+ + +  G T PP LL+EA
Sbjct: 464 QERFLASGLMVLARNYLDVYPYDHWSDKIIPVYERGSSFQPSTVEMVDGETSPPQLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F + +
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKCVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGA 641

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                +E++ A  E +R+C  C + DMVLK  + G F + C+GFP+CR+A+W P SV EA
Sbjct: 642 EVPQQEEIYPAMPEPIRKCPQCNK-DMVLKTRKSGGFYLSCVGFPKCRSAIWFPDSVLEA 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF+   IPP   +  +GCIGGCDE LR++ ++
Sbjct: 701 SRDESVCPVCQPQPVYRLKLKFKPGSIPPTMPLEFVGCIGGCDETLREILDL 752


>Q4W5X0_CHICK (tr|Q4W5X0) DNA topoisomerase OS=Gallus gallus GN=TOP3A PE=2 SV=1
          Length = 1020

 Score =  370 bits (950), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 187/412 (45%), Positives = 259/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL A+VQ Q   P WG +AQR+LD + G    P
Sbjct: 350 MRIAEKLYTQGFISYPRTETNIFPKELNLSALVQHQTQDPNWGAFAQRILD-QGG--PTP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++A   G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGTKSDQAHPPIHPTKYTANLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYL+VYP+E W   +IP Y  G +F PT + +  G T PP LL+EA
Sbjct: 464 NERFVAQGLMILARNYLEVYPYEKWSDKVIPLYQKGSRFQPTTVEMVDGETSPPLLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL +A++ +F  + 
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKSIVLHQQVQKYKQVFIEAVARANKLDQALAQYFGEAT 641

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                E    A    +R+C  C  +DMVLK  ++G F + C G+P C+ AVW P  V + 
Sbjct: 642 EIVEQEEVYPAMPVSIRKCPQCN-NDMVLKTKKNGGFYLSCTGYPACKTAVWFPDFVLDV 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           A   + C  C P PV+R++ KF++  +PP   ++ +GCIGGCD++L++L ++
Sbjct: 701 AKDESICAVCKPHPVHRLKFKFKRGSVPPTMPLDFVGCIGGCDQMLKELLDL 752


>F1P1F3_CHICK (tr|F1P1F3) DNA topoisomerase OS=Gallus gallus GN=TOP3A PE=3 SV=1
          Length = 1020

 Score =  369 bits (948), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 187/412 (45%), Positives = 258/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL A+VQ Q   P WG +AQR+LD + G    P
Sbjct: 350 MRIAEKLYTQGFISYPRTETNIFPKELNLSALVQHQTQDPNWGAFAQRILD-QGG--PTP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++A   G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGTKSDQAHPPIHPTKYTANLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYL+VYP+E W   +IP Y  G +F PT + +  G T PP LL+EA
Sbjct: 464 NERFVAQGLMILARNYLEVYPYEKWSDKVIPLYQKGSRFQPTTVEMVDGETSPPLLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL +A++ +F  + 
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKSIVLHQQVQKYKQVFIEAVARANKLDQALAQYFGEAT 641

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                E    A    +R+C  C  +DMVLK  ++G F + C G+P C+ AVW P  V + 
Sbjct: 642 EIVEQEEVYPAMPVSIRKCPQCN-NDMVLKTKKNGGFYLSCTGYPACKTAVWFPDFVLDV 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           A   + C  C P PV+R++ KF++  +PP   +  +GCIGGCD++L++L ++
Sbjct: 701 AKDESICAVCKPHPVHRLKFKFKRGSVPPTMPLEFVGCIGGCDQMLKELLDL 752


>E2RIS5_CANFA (tr|E2RIS5) DNA topoisomerase OS=Canis familiaris GN=TOP3A PE=3
           SV=1
          Length = 989

 Score =  369 bits (948), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 258/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    +L  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLDLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTSSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYERGSHFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    +  E +++C  C + DMVLK  ++G F + C GFP+CR+AVW P SV EA
Sbjct: 640 EVAQQEAIYPSMPEPIKKCPQCNK-DMVLKTKKNGGFYLSCTGFPECRSAVWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 699 SRDDSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLREILDL 750


>G3VJM6_SARHA (tr|G3VJM6) DNA topoisomerase OS=Sarcophilus harrisii GN=TOP3A PE=3
           SV=1
          Length = 897

 Score =  369 bits (947), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 189/420 (45%), Positives = 264/420 (62%), Gaps = 14/420 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F    NL  +VQ+Q    +WG +AQR+LD        P
Sbjct: 250 MKIAEKLYTQGYISYPRTETNIFPKDLNLTTLVQQQTHDQQWGAFAQRILDRGGP---TP 306

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A+G ETTVEIDIA
Sbjct: 307 RNGKKSDQAHPPIHPTKYTCNLQG---NEKRLYEFIVRHFLACCSEDALGQETTVEIDIA 363

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVY ++ W   +IP Y     F PT + +  G T PP LL+EA
Sbjct: 364 QERFVAHGLMILARNYLDVYIYDKWSDKVIPIYEKDSCFQPTTIEMVDGETSPPQLLTEA 423

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 424 DLIALMEKHGIGTDATHAEHIETIKSRMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 481

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A  +  KL EA+S +F + +
Sbjct: 482 SKPDLRAELEADLKLICEGKKDKHVVLRQQIQKYKQVFIEAVAHANKLDEALSQYFGEMA 541

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                +EL+ A  E +R+C  C + DMVLK+ ++G F + C+G+P CR A+W P SV E 
Sbjct: 542 TAVEQEELYPAMPETIRKCPQCNK-DMVLKRKKNGGFYISCMGYPDCRKAIWFPDSVLEV 600

Query: 370 AVTTNPCNFCTPGPVY--RIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI-CGTGP 426
           +   + C  C P PVY  R++LKF++  +PP   +  +GC+GGCDE L Q+ ++   +GP
Sbjct: 601 SKDESVCPVCKPHPVYRTRLKLKFKRGSVPPTMPLEFVGCVGGCDETLSQILDLRSSSGP 660


>F6QP60_MONDO (tr|F6QP60) DNA topoisomerase OS=Monodelphis domestica GN=TOP3A
           PE=3 SV=2
          Length = 904

 Score =  369 bits (946), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 190/412 (46%), Positives = 261/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F    NL A+VQ+Q    +WG +AQR+LD        P
Sbjct: 265 MKIAEKLYTQGYISYPRTETNIFPKDLNLTALVQQQIHDQQWGAFAQRILDRGGP---TP 321

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 322 RNGKKSDQAHPPIHPTKYTCNLQG---NEQRLYEFIVRHFLACCSEDAQGQETTVEIDIA 378

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL KNYL+VY ++ W   +IP Y  G +F PT + +  G T PP LL+EA
Sbjct: 379 QERFVAHGLMILAKNYLEVYLYDRWSDKIIPVYEKGSRFQPTTVEMVDGETSPPQLLTEA 438

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 439 DLIALMEKHGIGTDATHAEHIETIKSRMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 496

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A  +  KL EA+S +F + +
Sbjct: 497 SKPDLRAELEADLKLICEGKKDKHVVLRQQIQKYKQVFIEAVAHANKLDEALSQYFGEMA 556

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                +E++ A  E +R+C  C   DMVLK+ ++G F + C+G+P CR AVW P  V EA
Sbjct: 557 TAVRQEEIYPAMPETIRKCPQCHR-DMVLKRRKNGGFYLSCVGYPDCRKAVWFPDFVLEA 615

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF++  IPP   +  +GC+GGCDE L Q+ ++
Sbjct: 616 SKDGSVCPVCKPHPVYRLKLKFKRGSIPPAMPLELVGCVGGCDESLVQILDL 667


>A0JN73_BOVIN (tr|A0JN73) DNA topoisomerase OS=Bos taurus GN=TOP3A PE=2 SV=1
          Length = 1002

 Score =  369 bits (946), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 188/408 (46%), Positives = 256/408 (62%), Gaps = 10/408 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    +L A+V++Q   P WG +A+ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYEL+VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTDSLQG---DEQRLYELIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F  + 
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAAT 639

Query: 312 RSA-GDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             A  D L A  E +R+C  C   DMVLK  + G F +GC GFP+CR+AVW P SV EA+
Sbjct: 640 EVAPQDALPAVPEPIRKCPQCSR-DMVLKTRKSGGFYLGCTGFPECRSAVWFPDSVLEAS 698

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
              + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE LR++
Sbjct: 699 RDVSVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFVGCIGGCDETLREI 746


>F1MGY1_BOVIN (tr|F1MGY1) DNA topoisomerase OS=Bos taurus GN=TOP3A PE=3 SV=1
          Length = 1002

 Score =  369 bits (946), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 188/408 (46%), Positives = 256/408 (62%), Gaps = 10/408 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    +L A+V++Q   P WG +A+ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYEL+VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTDSLQG---DEQRLYELIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F  + 
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAAT 639

Query: 312 RSA-GDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             A  D L A  E +R+C  C   DMVLK  + G F +GC GFP+CR+AVW P SV EA+
Sbjct: 640 EVAPQDALPAVPEPIRKCPQCSR-DMVLKTRKSGGFYLGCTGFPECRSAVWFPDSVLEAS 698

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
              + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE LR++
Sbjct: 699 RDVSVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFVGCIGGCDETLREI 746


>L8J1J2_BOSMU (tr|L8J1J2) DNA topoisomerase OS=Bos grunniens mutus GN=M91_01740
           PE=3 SV=1
          Length = 1002

 Score =  369 bits (946), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 188/408 (46%), Positives = 256/408 (62%), Gaps = 10/408 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    +L A+V++Q   P WG +A+ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLDLAALVEQQTPDPRWGAFARNILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYEL+VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTDSLQG---DEQRLYELIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYEQGTCFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F  + 
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKLVVLHQQVQKYKQVFIEAVAKARKLDEALSQYFGAAT 639

Query: 312 RSA-GDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             A  D L A  E +R+C  C   DMVLK  + G F +GC GFP+CR+AVW P SV EA+
Sbjct: 640 EVAPQDALPAVPEPIRKCPQCSR-DMVLKTRKSGGFYLGCTGFPECRSAVWFPDSVLEAS 698

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
              + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE LR++
Sbjct: 699 RDVSVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFVGCIGGCDETLREI 746


>G5BMX8_HETGA (tr|G5BMX8) DNA topoisomerase OS=Heterocephalus glaber GN=GW7_07661
           PE=3 SV=1
          Length = 991

 Score =  368 bits (945), Expect = 2e-99,   Method: Compositional matrix adjust.
 Identities = 185/409 (45%), Positives = 256/409 (62%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P+WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLMALVEQQTQDPDWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYEL+VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTSNLQG---DEQRLYELIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G QF P+ + +  G T PP LL+EA
Sbjct: 462 QERFVARGLMILARNYLDVYPYDRWSDKLLPVYEEGSQFQPSTIEMLDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
            +   E    A  E +R+C  C + D+VLK  + G F +GC  FP+CR A+W P SV E 
Sbjct: 640 ETPQQEEIYPAMPEPIRKCPQCNK-DIVLKTKKSGGFYLGCTSFPECRLAMWFPDSVLEV 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE L ++
Sbjct: 699 SRDESVCPVCQPAPVYRLKFKFKRGSLPPTIPLEFVGCIGGCDETLNEI 747


>K7GGN4_PELSI (tr|K7GGN4) DNA topoisomerase OS=Pelodiscus sinensis GN=TOP3A PE=3
           SV=1
          Length = 1016

 Score =  368 bits (944), Expect = 3e-99,   Method: Compositional matrix adjust.
 Identities = 188/412 (45%), Positives = 261/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           ++VAE+LY  G+ISYPRTET+ F    NL ++VQ+Q  +  WG +AQR+LD + G    P
Sbjct: 350 MRVAEKLYTQGYISYPRTETNIFPKDLNLTSLVQQQTQNINWGAFAQRILD-QGGP--TP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGTKSDQAHPPIHPTKYTGDLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP+E W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 464 NERFVAHGLMILARNYLDVYPYEKWSDKVLPVYERGSRFQPSTVEMVDGETSPPQLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 524 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTPDQRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F  A     KL +A+S +F + +
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKSVVLRQQVAKYKHVFTEAVAKANKLDQALSQYFGEVT 641

Query: 311 NRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++    V +R+C  C  SDMVLK  ++G F +GC+ +P CR AVW P  V E 
Sbjct: 642 ELAQQEEIYPAMPVPIRKCPRCG-SDMVLKSRKNGGFYLGCMNYPNCRAAVWFPDCVLEV 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 701 SKDDSVCAVCKPHPVYRLKFKFKRGSVPPLLPLEFVGCIGGCDETLREILDL 752


>K7GGM4_PELSI (tr|K7GGM4) DNA topoisomerase OS=Pelodiscus sinensis GN=TOP3A PE=3
           SV=1
          Length = 1038

 Score =  368 bits (944), Expect = 3e-99,   Method: Compositional matrix adjust.
 Identities = 188/412 (45%), Positives = 261/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           ++VAE+LY  G+ISYPRTET+ F    NL ++VQ+Q  +  WG +AQR+LD + G    P
Sbjct: 350 MRVAEKLYTQGYISYPRTETNIFPKDLNLTSLVQQQTQNINWGAFAQRILD-QGGP--TP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGTKSDQAHPPIHPTKYTGDLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP+E W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 464 NERFVAHGLMILARNYLDVYPYEKWSDKVLPVYERGSRFQPSTVEMVDGETSPPQLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 524 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTPDQRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F  A     KL +A+S +F + +
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKSVVLRQQVAKYKHVFTEAVAKANKLDQALSQYFGEVT 641

Query: 311 NRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++    V +R+C  C  SDMVLK  ++G F +GC+ +P CR AVW P  V E 
Sbjct: 642 ELAQQEEIYPAMPVPIRKCPRCG-SDMVLKSRKNGGFYLGCMNYPNCRAAVWFPDCVLEV 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 701 SKDDSVCAVCKPHPVYRLKFKFKRGSVPPLLPLEFVGCIGGCDETLREILDL 752


>M3XLT6_MUSPF (tr|M3XLT6) DNA topoisomerase OS=Mustela putorius furo GN=Top3a
           PE=3 SV=1
          Length = 994

 Score =  367 bits (942), Expect = 5e-99,   Method: Compositional matrix adjust.
 Identities = 186/412 (45%), Positives = 258/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLTVLVEQQIPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S  A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTGSLQG---DEQRLYEFIVRHFLACCSHDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W    +P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLVILARNYLDVYPYDHWSDKTLPVYERGARFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKWVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGEGA 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A +E    +  E +++C  C + DMVLK  ++G F + C GFP+CR+AVW P SV EA
Sbjct: 640 EVAQEEAIYPSMPEPIKKCPQCNK-DMVLKTKKNGGFYLSCTGFPECRSAVWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 699 SRDASVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLREILDL 750


>F6YMD1_HORSE (tr|F6YMD1) DNA topoisomerase (Fragment) OS=Equus caballus GN=TOP3A
           PE=3 SV=1
          Length = 988

 Score =  367 bits (942), Expect = 5e-99,   Method: Compositional matrix adjust.
 Identities = 188/412 (45%), Positives = 256/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 329 MRIAEKLYTQGYISYPRTETNIFPRDLNLTALVEQQTPDPRWGAFAQSILERGGP---TP 385

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 386 RNGNKSDQAHPPIHPTKYTSNLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 442

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 443 QERFVAHGLVILARNYLDVYPYDHWSNKTLPVYERGFCFQPSTVEMVDGETSPPQLLTEA 502

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 503 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDS--MGYEM 560

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 561 SKPDLRAELEADLKLICEGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGA 620

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                E       E +R+C  C + DMVLK  + G F + C GFP+CR+AVW P SV EA
Sbjct: 621 EVPQQEAIYPTVPEPIRKCPQCNK-DMVLKTKKSGGFYLSCTGFPECRSAVWFPSSVLEA 679

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 680 SRDGSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLREILDL 731


>F6Z6P9_MACMU (tr|F6Z6P9) DNA topoisomerase OS=Macaca mulatta PE=3 SV=1
          Length = 1003

 Score =  367 bits (941), Expect = 7e-99,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 260/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 350 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 464 QERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 582 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 641

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+A+WLP SV EA
Sbjct: 642 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAMWLPDSVLEA 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 701 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 752


>M3ZNA2_XIPMA (tr|M3ZNA2) DNA topoisomerase OS=Xiphophorus maculatus GN=TOP3A
           PE=3 SV=1
          Length = 1023

 Score =  367 bits (941), Expect = 7e-99,   Method: Compositional matrix adjust.
 Identities = 193/418 (46%), Positives = 259/418 (61%), Gaps = 21/418 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G ISYPRTET+ F     L  +V++Q   PEWG +AQR+LD   G   NP
Sbjct: 363 MKIAEKLYTRGLISYPRTETNIFPANLPLAPLVEQQAQSPEWGTFAQRVLDQPGG--PNP 420

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G + D+AHPPIHPTK++    G   N  ++YE +VRHFLACVS+ A+G ET VEI+IA
Sbjct: 421 RQGKNSDQAHPPIHPTKYTNTLQG---NEARVYEFIVRHFLACVSQDALGHETVVEIEIA 477

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FS  G +I+ +NYLDVYP+E W   LIP Y  G QF P+A+ +  G T PP LL+EA
Sbjct: 478 QEKFSTSGLMIIARNYLDVYPYERWSTKLIPVYEQGSQFQPSAIEMVDGQTSPPQLLTEA 537

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RF P  LG  LV GY+   M Y++
Sbjct: 538 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFLPGELGMGLVEGYNS--MGYEM 595

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K KA F+ +     KL EA+S +     
Sbjct: 596 SKPNLRAELEADLKLVSEGRKDKRSVLQHHIQKYKAVFIESVRKAKKLDEALSPYL---- 651

Query: 312 RSAGDELHATGEV-------VRRCGLCQESDMVLKKNRDGNF-MVGCLGFPQCRNAVWLP 363
             A  EL    ++       VR+C  C   DMVLKK R+GN   + C+GFP C+ AVW P
Sbjct: 652 -GAALELPDAEQLDMEVPLPVRKCPNCGR-DMVLKKKREGNSRFLACVGFPACKTAVWFP 709

Query: 364 GSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            +V E +     C  C P P++ ++ KFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 710 DAVLEVSRDDGVCPTCQPSPIHLLKFKFRRGSVPPMMPLEFVGCIGGCDETLREVLDL 767


>H9Z0Q7_MACMU (tr|H9Z0Q7) DNA topoisomerase OS=Macaca mulatta GN=TOP3A PE=2 SV=1
          Length = 1001

 Score =  367 bits (941), Expect = 8e-99,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 260/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 580 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+A+WLP SV EA
Sbjct: 640 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAMWLPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 699 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 750


>H9EWR7_MACMU (tr|H9EWR7) DNA topoisomerase OS=Macaca mulatta GN=TOP3A PE=2 SV=1
          Length = 1001

 Score =  366 bits (940), Expect = 8e-99,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 260/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 580 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+A+WLP SV EA
Sbjct: 640 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAMWLPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 699 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 750


>G7PTT8_MACFA (tr|G7PTT8) DNA topoisomerase (Fragment) OS=Macaca fascicularis
           GN=EGM_07494 PE=3 SV=1
          Length = 839

 Score =  366 bits (940), Expect = 9e-99,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 260/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 186 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 242

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 243 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 299

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 300 QERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEA 359

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 360 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 417

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 418 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 477

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+A+WLP SV EA
Sbjct: 478 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAMWLPDSVLEA 536

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 537 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 588


>G3GVI0_CRIGR (tr|G3GVI0) DNA topoisomerase OS=Cricetulus griseus GN=I79_001720
           PE=3 SV=1
          Length = 1004

 Score =  366 bits (940), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 188/409 (45%), Positives = 254/409 (62%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTLDPHWGAFAQNILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AH PIHPTK+++   G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHSPIHPTKYTSNLQG---DERRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFIAHGLVILARNYLDVYPYDHWSDKLLPVYEQGFSFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +     
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGEGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                E    A  E VR+C  C + DMVLK  + G F + C GFP+CR AVW P SV EA
Sbjct: 640 EVVQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCTGFPECRAAVWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +  +  C+ C P PVYR++LKF++  +PP   +  +GCIGGCDE L+++
Sbjct: 699 SRDSTVCSICQPPPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLKEI 747


>G1RUU7_NOMLE (tr|G1RUU7) DNA topoisomerase OS=Nomascus leucogenys GN=TOP3A PE=3
           SV=1
          Length = 1001

 Score =  366 bits (940), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 263/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDI 
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIT 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G VIL +NYLDVYP++ W   ++P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLVILARNYLDVYPYDHWSDKILPIYERGSCFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F  R+
Sbjct: 580 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNRT 639

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+AVWLP SV EA
Sbjct: 640 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 699 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 750


>G1N063_MELGA (tr|G1N063) DNA topoisomerase OS=Meleagris gallopavo GN=TOP3A PE=3
           SV=1
          Length = 1020

 Score =  366 bits (939), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 188/412 (45%), Positives = 259/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL A+VQ Q   P WG +AQR+LD + G    P
Sbjct: 350 MRIAEKLYTQGFISYPRTETNIFPKELNLSALVQHQTQDPNWGAFAQRILD-QGG--PTP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++A   G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGTKSDQAHPPIHPTKYTANLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYL+VYP+E W   +IP Y  G +F PT + +  G T PP LL+EA
Sbjct: 464 NERFIAQGLMILARNYLEVYPYEKWSDKVIPLYQKGSRFQPTTVEMVDGETSPPLLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL +A++ +F    
Sbjct: 582 SKPDLRAELEADLKLICEGKKDKSIVLQQQVQKYKQVFIEAVARANKLDQALAQYFGEGT 641

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A    +R+C  C  +DMVLK  ++G F + C+G+P C+ AVW P  V + 
Sbjct: 642 EIAEQEEVYPAMPVSIRKCPQCN-NDMVLKTKKNGGFYLSCMGYPACKTAVWFPDFVLDV 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           A   + C  C P PV+R++ KF++  +PP   +  +GCIGGCD++L++L ++
Sbjct: 701 AKDESICAVCKPHPVHRLKFKFKRGSVPPTMPLEFVGCIGGCDQMLKELLDL 752


>F6Z0N0_ORNAN (tr|F6Z0N0) DNA topoisomerase (Fragment) OS=Ornithorhynchus
           anatinus GN=TOP3A PE=3 SV=1
          Length = 940

 Score =  365 bits (938), Expect = 1e-98,   Method: Compositional matrix adjust.
 Identities = 189/413 (45%), Positives = 262/413 (63%), Gaps = 12/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+VQ+Q     WG +AQR+LD        P
Sbjct: 288 MRIAEKLYTHGYISYPRTETNIFPKDLNLVALVQQQTQDQHWGDFAQRILDRGGP---TP 344

Query: 72  RGGGHDDKAHPPIHPTKFSAG-ESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           R G   D+AHPPIHPTK++   + G   + ++LYE +VRHFLAC S+ A G ETTVEIDI
Sbjct: 345 RNGNKSDQAHPPIHPTKYTCNLQQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDI 401

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           A E F A G +IL +NYL+VYP++ W   +IP Y  G +F PT + +  G T PP LL+E
Sbjct: 402 AHERFVAHGLMILARNYLEVYPYDRWSDKVIPIYEKGFRFQPTTVEMVEGETSPPQLLTE 461

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL+S M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y+
Sbjct: 462 ADLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADKRFLPGHLGMGLVEGYD--AMGYE 519

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QR 309
           + KP LR+ +E+D+K + EG K K  VL   + K +  F+ A     KL EA+S +F + 
Sbjct: 520 MSKPNLRAELEADLKLICEGKKDKFVVLTQQVQKYRQVFIEAAAKANKLDEALSQYFGEA 579

Query: 310 SNRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           +  S  +E++    V +R+C  C + DMVLK  ++G F +GCLG+P C+ AVW P SV E
Sbjct: 580 AEVSQQEEIYPAMPVPIRKCPQCNK-DMVLKTKKNGGFYLGCLGYPACKAAVWFPDSVLE 638

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            +   + C  C P PVY+++ KF++  IPP   +  +GCIGGCDE LR++ ++
Sbjct: 639 VSKDDSVCPDCVPHPVYKLKFKFKRGSIPPTMPLEFVGCIGGCDETLREILDL 691


>G3NY50_GASAC (tr|G3NY50) DNA topoisomerase (Fragment) OS=Gasterosteus aculeatus
           GN=TOP3A PE=3 SV=1
          Length = 964

 Score =  365 bits (938), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 190/413 (46%), Positives = 258/413 (62%), Gaps = 11/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F     L  +V++Q   P WG +AQR++D   G   NP
Sbjct: 319 MKIAEKLYTQGYISYPRTETNIFPTTLALGPLVEQQTQSPVWGTFAQRVIDQPGG--PNP 376

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK S+   G   N  +LYE +VRHFLACVS+ A+G ET V+IDIA
Sbjct: 377 RQGKKSDQAHPPIHPTKHSSTLQG---NEGRLYEFIVRHFLACVSQDALGQETVVDIDIA 433

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FS  G +I+ +NYLDVYP++ W   +IP Y  G QF P+A+ +  G T PP LL+EA
Sbjct: 434 QENFSTSGLMIIARNYLDVYPYDRWSAKVIPVYEQGSQFQPSAIEMADGQTSPPQLLTEA 493

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RF P  LG  LV GY+   M Y++
Sbjct: 494 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFLPGELGMGLVEGYNS--MGYEM 551

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K K  F+ +     KL EA+S +   + 
Sbjct: 552 SKPNLRAELEADLKLVSEGRKDKQSVLQNHIQKYKTVFIESVRKAKKLDEALSQYLGAAQ 611

Query: 312 RSAGDELHATGE--VVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSE 368
             A  E         VR+C  C++ DMVLKK R+GN   + C G+P C+ AVW P +V E
Sbjct: 612 EIAEAEQQDMEMPLPVRKCPNCRQ-DMVLKKKREGNGKYLSCSGYPACKTAVWFPDTVLE 670

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            +   + C  C P PV+ ++LKFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 671 VSRDDSICPTCQPHPVHMLKLKFRRGSLPPMMPLEFVGCIGGCDETLREVLDL 723


>G1LDT8_AILME (tr|G1LDT8) DNA topoisomerase OS=Ailuropoda melanoleuca
           GN=LOC100472522 PE=3 SV=1
          Length = 959

 Score =  365 bits (937), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 185/412 (44%), Positives = 256/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLTVLVEQQTQDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTGSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDHWSDKTLPVYERGACFQPSTVAMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTADKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKWVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGEGA 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    +  E +R+C  C + DMVLK  ++G F + C GFP+CR+A+W P SV EA
Sbjct: 640 EVAQQEAIYPSLPEPIRKCPQCNK-DMVLKTKKNGGFYLSCTGFPECRSAMWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +     C  C P PVYR++LKF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 699 SRDGTVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVGCIGGCDETLREILDL 750


>F7A1S4_XENTR (tr|F7A1S4) DNA topoisomerase (Fragment) OS=Xenopus tropicalis
           GN=top3a PE=3 SV=1
          Length = 1021

 Score =  365 bits (937), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 187/413 (45%), Positives = 263/413 (63%), Gaps = 12/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAE+LY  GFISYPRTET+ F    NL ++V++Q    +WG +AQR+L+        P
Sbjct: 352 MKVAEKLYTQGFISYPRTETNIFPKDLNLTSLVEQQTHDHQWGGFAQRILERGGP---TP 408

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N +++YE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 409 RNGNKTDQAHPPIHPTKYTNSLQG---NEQRIYEFIVRHFLACCSQDAQGQETTVEIDIA 465

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +I+ +NYLDVYP++ W   +IP Y +G +F P+ + +  G T PP LL+EA
Sbjct: 466 AERFVAHGLMIIARNYLDVYPYDKWNTKIIPVYEMGARFQPSTVEMVDGETSPPQLLTEA 525

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M +++
Sbjct: 526 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTPEQRFLPGELGMGLVEGYDS--MGFEM 583

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +ESD+K + EG K K +VL   + K K  F+ A     KL EA+S +F Q +
Sbjct: 584 SKPDLRAELESDLKLICEGKKDKFSVLRLQVQKYKQVFVEAAAKATKLDEALSQYFGQAA 643

Query: 311 NRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                +E++A   + VR+C  C + DMVLK  RDG F + C+G+P C+++VW P  V E 
Sbjct: 644 QPVPQEEIYADTPLPVRKCPQCNK-DMVLKTKRDGGFFLSCVGYPGCKSSVWFPSFVLEV 702

Query: 370 AVTTNPCNFCTPGPVY-RIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVY R+++KF++  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 703 SRDESICGTCKPHPVYNRLKMKFKRGSVPPLMPLEFVGCIGGCDETLREILDL 755


>B4DK80_HUMAN (tr|B4DK80) DNA topoisomerase OS=Homo sapiens GN=TOP3A PE=2 SV=1
          Length = 906

 Score =  365 bits (936), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 185/416 (44%), Positives = 261/416 (62%), Gaps = 11/416 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 253 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 309

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 310 RNGNKSDQAHPPIHPTKYTNNLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 366

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 367 QERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEA 426

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 427 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 484

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 485 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 544

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+AVWLP SV EA
Sbjct: 545 ELAQQEDIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEA 603

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCD+ LR++ ++  +G
Sbjct: 604 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSG 659


>H2R419_PANTR (tr|H2R419) DNA topoisomerase OS=Pan troglodytes GN=TOP3A PE=2 SV=1
          Length = 1001

 Score =  365 bits (936), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 184/412 (44%), Positives = 259/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 580 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+AVWLP SV EA
Sbjct: 640 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCD+ LR++ ++
Sbjct: 699 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDL 750


>G3QKQ6_GORGO (tr|G3QKQ6) DNA topoisomerase OS=Gorilla gorilla gorilla GN=TOP3A
           PE=3 SV=1
          Length = 1002

 Score =  365 bits (936), Expect = 2e-98,   Method: Compositional matrix adjust.
 Identities = 184/412 (44%), Positives = 259/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 349 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 405

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 406 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 462

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 463 QERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEA 522

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 523 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 580

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 581 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 640

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+AVWLP SV EA
Sbjct: 641 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEA 699

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCD+ LR++ ++
Sbjct: 700 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDL 751


>K9J3S6_DESRO (tr|K9J3S6) DNA topoisomerase (Fragment) OS=Desmodus rotundus PE=2
           SV=1
          Length = 837

 Score =  364 bits (934), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 185/409 (45%), Positives = 254/409 (62%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 186 MRIAEKLYTQGYISYPRTETNVFPKDLNLTALVEQQTPDPHWGSFAQSILERGGP---TP 242

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 243 RNGNKSDQAHPPIHPTKYTSSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 299

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 300 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYERGSRFQPSTMQMVDGETSPPQLLTEA 359

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 360 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYD--AMGYEM 417

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 418 SKPDLRAELEADLKLICEGKKDKCVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGA 477

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E VR+C  C + DMVLK  + G F + C GFP+CR+ +W P SV EA
Sbjct: 478 EVAQQEAIYPAMLEPVRKCPQCNK-DMVLKTKKSGGFYLSCTGFPECRSVMWFPDSVLEA 536

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE L+++
Sbjct: 537 SRDASVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFIGCIGGCDETLKEI 585


>G7NJ30_MACMU (tr|G7NJ30) DNA topoisomerase OS=Macaca mulatta GN=EGK_08270 PE=3
           SV=1
          Length = 1001

 Score =  364 bits (934), Expect = 4e-98,   Method: Compositional matrix adjust.
 Identities = 184/412 (44%), Positives = 259/412 (62%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A   VIL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHSLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F    
Sbjct: 580 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+A+WLP SV EA
Sbjct: 640 ELAQQEEIYPAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAMWLPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  ++ C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 699 SRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 750


>K9INH6_DESRO (tr|K9INH6) DNA topoisomerase OS=Desmodus rotundus PE=2 SV=1
          Length = 999

 Score =  363 bits (933), Expect = 5e-98,   Method: Compositional matrix adjust.
 Identities = 185/409 (45%), Positives = 254/409 (62%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNVFPKDLNLTALVEQQTPDPHWGSFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTSSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYERGSRFQPSTMQMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYD--AMGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKCVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGA 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E VR+C  C + DMVLK  + G F + C GFP+CR+ +W P SV EA
Sbjct: 640 EVAQQEAIYPAMLEPVRKCPQCNK-DMVLKTKKSGGFYLSCTGFPECRSVMWFPDSVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE L+++
Sbjct: 699 SRDASVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFIGCIGGCDETLKEI 747


>H0Z9W6_TAEGU (tr|H0Z9W6) DNA topoisomerase (Fragment) OS=Taeniopygia guttata
           GN=TOP3A PE=3 SV=1
          Length = 980

 Score =  363 bits (931), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 188/417 (45%), Positives = 264/417 (63%), Gaps = 11/417 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE+LY  GFISYPRTET+ F    NL A+V++Q   P WG +AQR+LD + G    P
Sbjct: 332 MTIAEKLYTKGFISYPRTETNIFPKELNLSALVEQQTQDPNWGGFAQRILD-QGG--PTP 388

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   N ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 389 RSGTKSDQAHPPIHPTKYTSNLQG---NEQRLYEFIVRHFLACCSQDAKGQETTVEIDIA 445

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYL+VYP++ W   +IP Y  G +F PT + +  G T PP LL+EA
Sbjct: 446 NEQFIAQGLMILARNYLEVYPYDKWSDKVIPLYHKGSRFQPTTVEMVDGETSPPLLLTEA 505

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    A  RF P  LG  LV GYD   M Y++
Sbjct: 506 DLIALMEKHGIGTDATHAEHIETIKTRMYVGLTADQRFLPGQLGMGLVEGYDS--MGYEM 563

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL +A++ +  + +
Sbjct: 564 SKPDLRAELEADLKLICEGKKDKSVVLQQQVQKYKQVFIEAVARANKLDQALAQYLGEAA 623

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                DE++ AT   VR+C  C  SDMVLK  ++G F + C+G+P C+ AVW P  V + 
Sbjct: 624 EIPEQDEVYPATPVSVRKCPQCN-SDMVLKTRKNGGFYLSCMGYPACKTAVWFPDFVVDV 682

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGP 426
               + C+ C P PV+R++ KF++  +PP   +  +GCIGGCDE+L++L ++  + P
Sbjct: 683 TRDESICDVCKPHPVHRLKFKFKKGSVPPVMPLEFVGCIGGCDEMLKELLDLKSSQP 739


>H0X7X3_OTOGA (tr|H0X7X3) DNA topoisomerase OS=Otolemur garnettii GN=TOP3A PE=3
           SV=1
          Length = 1002

 Score =  363 bits (931), Expect = 1e-97,   Method: Compositional matrix adjust.
 Identities = 183/412 (44%), Positives = 261/412 (63%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTALVEQQTQDPHWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ET+VEIDIA
Sbjct: 405 RNGSKSDQAHPPIHPTKYTSSLEG---DEQRLYEFIVRHFLACCSQDAQGQETSVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 RERFVAQGLMILARNYLDVYPYDRWSDKILPVYEQGSRFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA++ +F + +
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGEGA 639

Query: 311 NRSAGDELHAT-GEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             +  +E++ T  E VR+C  C + DMVLK  + G F + C+GFP+CR A+W P SV E 
Sbjct: 640 EVAQQEEIYPTMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCIGFPECRAALWFPDSVLEV 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +   + C  C P PVYR++ KF++  +PP   +  +GCIGGCDE LR+  ++
Sbjct: 699 SRDGSVCPVCHPQPVYRLKFKFKRGSLPPTMPLEFVGCIGGCDETLRETLDL 750


>H0VEI8_CAVPO (tr|H0VEI8) DNA topoisomerase OS=Cavia porcellus GN=LOC100733021
           PE=3 SV=1
          Length = 1002

 Score =  362 bits (929), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 182/409 (44%), Positives = 252/409 (61%), Gaps = 11/409 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLMALVEQQTQDPHWGPFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGNKSDQAHPPIHPTKYTSNLQG---DERRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G  IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 RERFVANGLTILARNYLDVYPYDRWSDKLLPVYEEGSHFQPSTIEMLDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +F    
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGT 639

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
            +   E    A  E + +C  C + D+VLK  + G F + C GFP+CR A+W P SV E 
Sbjct: 640 ETLQQEEIYPAMPEPILKCPQCNK-DLVLKTKKSGGFYLSCTGFPECRLAMWFPDSVLEV 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           +   + C  C P PVYR++ +F++  +PP   +  +GCIGGCDE L+++
Sbjct: 699 SRDGSVCPVCQPAPVYRLKFRFKRGSLPPTMPLEFVGCIGGCDETLKEI 747


>H2SSS8_TAKRU (tr|H2SSS8) DNA topoisomerase (Fragment) OS=Takifugu rubripes
           GN=LOC101078908 PE=3 SV=1
          Length = 966

 Score =  361 bits (926), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 190/414 (45%), Positives = 258/414 (62%), Gaps = 13/414 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F P   L  +V+EQ     WG +AQR+L+   G   NP
Sbjct: 319 MKIAEKLYTRGFISYPRTETNIFPPNLALGPLVEEQTQSSVWGAFAQRVLEQPGG--PNP 376

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK S+   G   N  +LYE +VRHFLACVS+ A+G ET V++DIA
Sbjct: 377 RQGKKSDQAHPPIHPTKHSSSLQG---NEGRLYEFIVRHFLACVSQDALGQETVVDVDIA 433

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FS  G +I  +NYLDVYP++ W   LIP Y  G QF PTA+ +  G T PP LL+EA
Sbjct: 434 QEKFSTSGLMITARNYLDVYPYDRWTTKLIPVYEQGSQFQPTAIEMVDGQTSPPQLLTEA 493

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P  LG  LV GY+   M Y++
Sbjct: 494 DLIALMEKHGIGTDATHAEHIETIKSRMYVGLTSDQRFLPGELGMGLVEGYNS--MGYEM 551

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K K  F+ +     KL EA+S +   + 
Sbjct: 552 SKPNLRAELEADLKLVSEGRKDKWSVLQHHIQKYKTVFIESVHKAKKLDEALSPYLG-AA 610

Query: 312 RSAGDELHATGEV---VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVS 367
           +   +E     E+   +R+C  C   DMVLKK R+GN   + C+G+P C+ AVW P  V 
Sbjct: 611 QEIPEEQQQDMEIPLPIRKCPHCGR-DMVLKKKREGNGKYLTCVGYPACKTAVWFPDMVL 669

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           E +   + C  C P PV+ ++LKFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 670 EVSRDQSICPTCRPAPVHMLKLKFRRGSLPPMMPLEFVGCIGGCDETLREVLDL 723


>F1R242_DANRE (tr|F1R242) DNA topoisomerase (Fragment) OS=Danio rerio GN=top3a
           PE=3 SV=1
          Length = 1009

 Score =  360 bits (925), Expect = 4e-97,   Method: Compositional matrix adjust.
 Identities = 191/414 (46%), Positives = 260/414 (62%), Gaps = 14/414 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    NL  +V++Q    EWG +AQR+L  E+G    P
Sbjct: 346 MKIAEKLYTQGFISYPRTETNMFPQNLNLTRLVEQQTQDQEWGNFAQRIL--ESG-GPTP 402

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++ G  G   N ++LYE +VRHFLAC SK A G E TVEIDIA
Sbjct: 403 RNGNKSDQAHPPIHPTKYTNGLQG---NEKRLYEFIVRHFLACCSKDAQGQEVTVEIDIA 459

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G  I+ +NYL+VYP++ W   +IP+Y+    F PTA+ +  G T PP LL+EA
Sbjct: 460 EERFSASGLTIIARNYLEVYPYDKWYNKVIPSYSPNTTFQPTAIEMVEGQTSPPQLLTEA 519

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RF P  LG  LV GY+   M Y++
Sbjct: 520 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFLPGELGMGLVEGYNS--MGYEM 577

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K VSEG K K +VL+  + K KA F+ +     KL EA+S +   + 
Sbjct: 578 SKPDLRAELEADLKLVSEGRKNKASVLSYHVAKYKAVFIESVRKAKKLDEALSNYLGPAQ 637

Query: 312 RSAGDELHATGEV---VRRCGLCQESDMVLKKNRDGNFM-VGCLGFPQCRNAVWLPGSVS 367
             A  E     E+   VR+C  C   DMVLKK +D   M + CLG+P C+ AVW P +V 
Sbjct: 638 EIAEQE-QVELEIPLPVRKCPQCNR-DMVLKKKKDSTGMLLSCLGYPACKAAVWFPDTVL 695

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           E +   + C  C P PV+ ++ KF++  +PP   +  +GCIGGCD+ LR++  +
Sbjct: 696 EVSRDESICPTCRPHPVHMLKFKFKRGSLPPMMPLEFVGCIGGCDDTLREVLNL 749


>H3CL93_TETNG (tr|H3CL93) DNA topoisomerase (Fragment) OS=Tetraodon nigroviridis
           GN=TOP3A (1 of 2) PE=3 SV=1
          Length = 953

 Score =  360 bits (923), Expect = 7e-97,   Method: Compositional matrix adjust.
 Identities = 189/414 (45%), Positives = 261/414 (63%), Gaps = 14/414 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F     L ++V+EQ     WG +AQR+LD   G   +P
Sbjct: 316 MKIAEKLYTQGFISYPRTETNIFPKTLALGSLVEEQTQSSVWGTFAQRVLDQPGG--PSP 373

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPT+ S+   G   N  +LYE +VRHFLACVS+ A+G ET V++DIA
Sbjct: 374 RQGKKSDQAHPPIHPTRHSSSLQG---NEGRLYEFIVRHFLACVSQDALGQETVVDVDIA 430

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G +I+ +NYLDVYP++ W   +IP Y  G QF PTA+ +  G T PP LL+EA
Sbjct: 431 QEKFSASGLMIIARNYLDVYPYDRWSTKVIPVYEQGSQFQPTAIEMVDGQTSPPQLLTEA 490

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT H HI+ +  R Y    +  RF P  LG  LV GY+   M Y++
Sbjct: 491 DLIALMEKHGIGTDAT-HAHIETIKSRMYVGLTSDQRFLPGELGMGLVEGYNS--MGYEM 547

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K K  F+ +     KL EA+S +   + 
Sbjct: 548 SKPNLRAELEADLKLVSEGRKDKRSVLGHHIQKYKTVFIESVQKAKKLDEALSPYLG-AA 606

Query: 312 RSAGDELHATGEV---VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVS 367
           +   +E     E+   VR+C  C   DMVLKK R+GN   + C+G+P C++AVW P +V 
Sbjct: 607 QEITEEQQQDMEIPLPVRKCPHCGR-DMVLKKKREGNGKYLTCVGYPACKSAVWFPDTVL 665

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           E +   + C  C P PV+ ++ KFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 666 EVSRDESVCPTCQPAPVHMLKFKFRRGSLPPVMPLEFVGCIGGCDETLREVLDL 719


>M3WMK3_FELCA (tr|M3WMK3) DNA topoisomerase OS=Felis catus GN=TOP3A PE=3 SV=1
          Length = 989

 Score =  358 bits (920), Expect = 2e-96,   Method: Compositional matrix adjust.
 Identities = 182/412 (44%), Positives = 252/412 (61%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 350 MRIAEKLYTQGYISYPRTETNIFPKDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 407 RNGNKSDQAHPPIHPTKYTSSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 463

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 464 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYERGSRFQPSTVEMVDGETSPPQLLTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 524 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K + EG K K  VL   + K K  F  A     KL EA+S +F    
Sbjct: 582 SKPNLRAELEADLKLICEGKKDKLVVLRQQVQKYKQVFTEAVAKAKKLDEALSQYFGEGA 641

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +++C  C + DMVL+  + G F + C GFP+CR+A+W P SV EA
Sbjct: 642 EVAQQEAIYPAMPEPIKKCPQCNK-DMVLRTKKSGGFYLSCTGFPECRSAMWFPDSVLEA 700

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +     C  C P PVYR++ KF++  +PP   +  +GC+GGCDE L +L ++
Sbjct: 701 SRDGTVCPVCQPHPVYRLKFKFKRGSLPPTMPLEFVGCVGGCDETLMELLDL 752


>C3Z742_BRAFL (tr|C3Z742) Putative uncharacterized protein (Fragment)
           OS=Branchiostoma floridae GN=BRAFLDRAFT_64736 PE=3 SV=1
          Length = 684

 Score =  356 bits (914), Expect = 8e-96,   Method: Compositional matrix adjust.
 Identities = 181/398 (45%), Positives = 245/398 (61%), Gaps = 12/398 (3%)

Query: 23  FISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNPRGGGHDDKAHP 82
           FISYPRTET+ FS  T+L  +VQ Q   P+WG +A  +L        NPR G   D AHP
Sbjct: 1   FISYPRTETNKFSKDTDLQGLVQLQTVDPDWGGFAAGVLQ----RGPNPRNGNKTDNAHP 56

Query: 83  PIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIAGELFSACGRVI 142
           PIHPTK++    G   N ++LYE +VRHFLAC+S+ A G ETTVEIDI GE F+A G +I
Sbjct: 57  PIHPTKYTDNLQG---NEKRLYEFIVRHFLACLSQDAQGQETTVEIDINGEKFTAQGLMI 113

Query: 143 LEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEADLLSCMDKEGI 202
           + +NYLDVYP++ W   +IP +  G+ F P+A+ +  G T PPPLL+EADL++ MDK GI
Sbjct: 114 IARNYLDVYPYDKWNAKVIPVFNQGETFQPSAIEMLQGQTSPPPLLTEADLIALMDKHGI 173

Query: 203 GTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPELRSAMES 262
           GTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y++ KP LR+ +E+
Sbjct: 174 GTDATHAEHIETIKSRMYVGVQQDGRFVPGELGMGLVEGYD--AMGYEMSKPHLRAELEA 231

Query: 263 DMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGDELH--A 320
           D+K + EG K    VLA  + K K  F+ A    +KL EA+  +F  +   A  +++   
Sbjct: 232 DLKLICEGRKDPKVVLAEQVQKYKQVFIEACAQALKLDEALGTYFGEAQPFAEQDMNPVQ 291

Query: 321 TGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFCT 380
               VR C  C ES MV+K  +DG  M+ C+G+P CR   W P +V EA      C  C 
Sbjct: 292 VSPPVRPCPQCGES-MVIKTRKDGGLMLSCMGYPDCRAVAWFPANVLEATRDEAICTRCQ 350

Query: 381 PGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           PGPV++I+ KF++  +PP   +++LGCIGGCDE + +L
Sbjct: 351 PGPVHKIKFKFKRGSVPPIIPLDYLGCIGGCDETVCEL 388


>H2Z239_CIOSA (tr|H2Z239) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 950

 Score =  354 bits (908), Expect = 5e-95,   Method: Compositional matrix adjust.
 Identities = 186/422 (44%), Positives = 256/422 (60%), Gaps = 13/422 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 322 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGGP--QP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 380 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 436

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T   PLL+EA
Sbjct: 437 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRT-TAPLLTEA 495

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 496 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 553

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A     KL EA+S +F  + 
Sbjct: 554 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEAIQKADKLDEALSAYFGDAT 613

Query: 312 RSAGDEL---HATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           R  G  L         VR C  C + DM+LKK RDG FM+ C G+P CRNA++LP SV +
Sbjct: 614 RVEGSNLLNPSGASPPVRPCPRCGK-DMILKKKRDGGFMLSCTGYPNCRNALFLPSSVLD 672

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPRM 428
             V ++ C  C P PV+++ +K     IP  ++ + + CIGGCD+ +  +  +   G R 
Sbjct: 673 ITVDSSVCPNCQPSPVHQVNVKLNPRSIPAYFSSDQIICIGGCDDDVTNVLVLGSRGAR- 731

Query: 429 PG 430
           PG
Sbjct: 732 PG 733


>G1NSV2_MYOLU (tr|G1NSV2) DNA topoisomerase OS=Myotis lucifugus PE=3 SV=1
          Length = 1004

 Score =  353 bits (905), Expect = 1e-94,   Method: Compositional matrix adjust.
 Identities = 182/412 (44%), Positives = 254/412 (61%), Gaps = 11/412 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTALVEQQTPDPRWGPFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDI+
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIS 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W    +P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDRWSDKTLPVYERGSCFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F  A     KL EA+S +F +R+
Sbjct: 580 SKPDLRAELEADLKLICEGRKDKSVVLRQQIQKYKTVFTEAVAKAKKLDEALSQYFGERA 639

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                + ++ A    VR+C  C + DMVLK  + G F + C GFP+CR+ +WLP  V EA
Sbjct: 640 EVPQEEAIYPAVPAPVRKCPQCNK-DMVLKTKKSGGFYLSCTGFPECRSVMWLPDFVLEA 698

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
               + C  C P PV+R++LK ++  +PP   +  +GCIGGCDE LR++  +
Sbjct: 699 CRDESVCPVCQPHPVHRLKLKCKRGSLPPTMPLEFVGCIGGCDETLREILNL 750


>H2Z235_CIOSA (tr|H2Z235) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 1011

 Score =  353 bits (905), Expect = 1e-94,   Method: Compositional matrix adjust.
 Identities = 182/405 (44%), Positives = 249/405 (61%), Gaps = 12/405 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 358 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGGP--QP 415

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 416 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 472

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T   PLL+EA
Sbjct: 473 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRT-TAPLLTEA 531

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 532 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 589

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A     KL EA+S +F  + 
Sbjct: 590 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEAIQKADKLDEALSAYFGDAT 649

Query: 312 RSAGDEL---HATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           R  G  L         VR C  C + DM+LKK RDG FM+ C G+P CRNA++LP SV +
Sbjct: 650 RVEGSNLLNPSGASPPVRPCPRCGK-DMILKKKRDGGFMLSCTGYPNCRNALFLPSSVLD 708

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDE 413
             V ++ C  C P PV+++ +K     IP  ++ + + CIGGCD+
Sbjct: 709 ITVDSSVCPNCQPSPVHQVNVKLNPRSIPAYFSSDQIICIGGCDD 753


>H2MFK0_ORYLA (tr|H2MFK0) DNA topoisomerase (Fragment) OS=Oryzias latipes
           GN=LOC101168371 PE=3 SV=1
          Length = 985

 Score =  353 bits (905), Expect = 1e-94,   Method: Compositional matrix adjust.
 Identities = 184/413 (44%), Positives = 253/413 (61%), Gaps = 11/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F     L  +V++Q     WG +AQR+LD   G   NP
Sbjct: 316 MKIAEKLYTQGFISYPRTETNIFPANLVLAPLVEQQTHSSTWGTFAQRVLDQPGG--PNP 373

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++   G   N  ++YE +VRHFLACVS+ A+G ET V+IDIA
Sbjct: 374 RQGKKSDQAHPPIHPTKYTSSLQG---NEARVYEFIVRHFLACVSQDALGQETVVDIDIA 430

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FS  G +I+ +NYLDVYP++ W   +IP Y    QF P+A+ +  G T PP LL+EA
Sbjct: 431 QEKFSTSGLMIIARNYLDVYPYDKWNAKVIPVYEEDSQFQPSAIEMVDGQTSPPQLLTEA 490

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RF P  LG  LV GY+   M Y++
Sbjct: 491 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFLPGELGMGLVEGYNS--MGYEM 548

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LRS +E+D+K VSEG K K  VL   + K K  F+ +     KL EA+S +   + 
Sbjct: 549 SKPNLRSELEADLKLVSEGRKDKRGVLQHHIQKYKTVFIESVRKAKKLDEALSAYLGAAL 608

Query: 312 R--SAGDELHATGEVVRRCGLCQESDMVLKKNRDGNF-MVGCLGFPQCRNAVWLPGSVSE 368
               A  +       VR+C  C   DMVLK+ R+G+   + C+G+P C+ AVW P  V +
Sbjct: 609 EIPEAQQQDLEMPLPVRKCPNCGR-DMVLKRKREGSSKFLTCVGYPACKTAVWFPDMVLD 667

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            +   + C  C P PV+ ++ KFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 668 VSRDESICPTCQPSPVHMLKFKFRRGSLPPMMPLEFVGCIGGCDETLREVLDL 720


>D8TMQ9_VOLCA (tr|D8TMQ9) DNA topoisomerase OS=Volvox carteri GN=VOLCADRAFT_79791
           PE=3 SV=1
          Length = 936

 Score =  348 bits (894), Expect = 2e-93,   Method: Compositional matrix adjust.
 Identities = 187/400 (46%), Positives = 246/400 (61%), Gaps = 14/400 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +K+AEELYQ GFISYPRTETD F P  +L  IV E  G P WG +AQR+L  E  LWR
Sbjct: 332 RIMKLAEELYQAGFISYPRTETDVFDPGMDLQGIVTEHTGDPRWGRHAQRILSGE--LWR 389

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR GGHDDKAHPPIHPT+ S GE  WS + R+LYE VVRHFLAC SK AVG+ET VEID
Sbjct: 390 QPRPGGHDDKAHPPIHPTRHSLGEHDWSHDKRQLYEFVVRHFLACCSKDAVGSETQVEID 449

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPPLL 188
           I GE F   G ++LE+N+LDVYP+  WGG+  +P  TVGQ F P+ + L +G T PPP L
Sbjct: 450 IGGERFRTTGLMVLERNWLDVYPYSGWGGNDNLPKLTVGQSFVPSEMRLRTGSTEPPPRL 509

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD-ASTRFTPTNLGEALVMGYDDIEM 247
           SE DL++ M+  GIGTDAT+ +HI+K L+R YA KD  +  F PT LGEAL+ GY  + +
Sbjct: 510 SERDLIAKMEAYGIGTDATVAEHIQKQLERGYAEKDEGALTFWPTPLGEALISGYCRMGL 569

Query: 248 AYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF 307
              LWKP+LR  +E+ ++ V+ G   KD VL  ++   +A FL A+     L   M+ F 
Sbjct: 570 D-DLWKPDLRGKIEASIRDVAAGRVSKDQVLQEAIQFFRADFLTAQQRAGMLAAEMARFL 628

Query: 308 QRSNRSAGDELHATGEVVRR-----CGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWL 362
             +    G      G          C  C  S +VL +  +G ++  C     C   + L
Sbjct: 629 PTAGGGGGGGGGGGGPPPVGPLLGTCQSCGGSSLVLTRGSEGRYVAVCSSTSVCGYRLAL 688

Query: 363 PGSVSEAAVTTNPCNFCT----PGPVYRIQLKFRQLEIPP 398
           P +V++A+V++ PC  C      GP+ R  L+FR  ++PP
Sbjct: 689 PRAVADASVSSQPCGRCALSGGGGPLMRADLRFRMGQMPP 728


>E9H1M6_DAPPU (tr|E9H1M6) DNA topoisomerase OS=Daphnia pulex GN=DAPPUDRAFT_324341
           PE=3 SV=1
          Length = 1025

 Score =  347 bits (891), Expect = 5e-93,   Method: Compositional matrix adjust.
 Identities = 189/422 (44%), Positives = 248/422 (58%), Gaps = 16/422 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    +L  +VQ Q   P WG +AQR+LD   GL  NP
Sbjct: 319 MKIAEKLYTQGFISYPRTETNIFPKELDLTPLVQCQTVDPAWGGFAQRVLD--EGL--NP 374

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++   S  ++N RKLYE +VRHFLACVSK A G ET  EI+I 
Sbjct: 375 RQGKKSDQAHPPIHPTKYAGNLS--NENERKLYEFIVRHFLACVSKDAQGYETVAEIEIQ 432

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G  I+ +NYL+VYP+E W    +P    GQ+F PT++T+D G T PP LLSEA
Sbjct: 433 EEGFVASGLQIVARNYLEVYPYERWSDRSLPQLNEGQRFIPTSITMDEGETSPPQLLSEA 492

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  DHI+ +  R YA      RF P +LG  LV GYD   M   L
Sbjct: 493 DLISLMEKHGIGTDATHADHIETIKSRQYAGVQGDGRFLPCSLGMGLVQGYD--AMGIAL 550

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K V +G +  + VL   +++ +  F+ A    +K+ EA+S FF    
Sbjct: 551 SKPNLRAELEADLKRVCDGERNPNDVLREQIERYRRVFVQAMEQVIKIDEALSTFFNEER 610

Query: 312 RSAGDELHATGEVV----RRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVS 367
           + A   +   G       R+C  C   DM L++ +D  F   C+GFP+C+ AVWLP +V 
Sbjct: 611 QEAPPMIPEGGPDANLPYRKCPACN-LDMTLRRKKDNGFFFSCMGFPECKTAVWLPSAVQ 669

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI--CGTG 425
           +  V    CN C   P   ++ +F      P Y   H GCIGGCD    +L  I    T 
Sbjct: 670 QVEVDAEKCNACPSHPSL-VRFQFTPGIYAPFYPDTHRGCIGGCDPNFMELLGIRPLATQ 728

Query: 426 PR 427
           PR
Sbjct: 729 PR 730


>R7TJU1_9ANNE (tr|R7TJU1) Uncharacterized protein OS=Capitella teleta
           GN=CAPTEDRAFT_193082 PE=4 SV=1
          Length = 934

 Score =  347 bits (889), Expect = 6e-93,   Method: Compositional matrix adjust.
 Identities = 181/413 (43%), Positives = 245/413 (59%), Gaps = 12/413 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    NL  ++Q+Q    +WG +A  +L+       NP
Sbjct: 317 MKIAEKLYTQGFISYPRTETNIFPKDLNLRNLIQQQVNDQDWGEFAGHILEDGP----NP 372

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++ G  G   N +++YE VVRHFLAC SK A G ETTV+I I 
Sbjct: 373 RNGNKTDQAHPPIHPTKYTNGLQG---NEKRVYEFVVRHFLACCSKDAQGQETTVDISIN 429

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G +I+ +NYLDVYP++ W G ++PT   G QFTP  + ++ G T  P LL+EA
Sbjct: 430 DEYFSASGLMIIARNYLDVYPYDKWTGKILPTMEEGAQFTPRTIEMNQGETSAPSLLTEA 489

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       +F P  LG  LV GYD   M + +
Sbjct: 490 DLISLMDKHGIGTDATHAEHIETIKARLYVGLTNDQKFIPGELGMGLVEGYD--AMGFHM 547

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K + EG K +D VLA  + K K  F+ A     K+  A++  F    
Sbjct: 548 SKPHLRAELENDLKLICEGKKNRDVVLADQIRKYKEVFVEACTQAEKIDTALAEHFGAPQ 607

Query: 312 R-SAGDELHATGE--VVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           + S  D L AT     V+ C  C     +  K  +  F +GC G+P CR  +WLP  V +
Sbjct: 608 QLSNQDLLQATAMAITVKPCSKCGMQMSLRTKKDNKGFFIGCSGYPTCREVIWLPDYVLK 667

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           A VT   C  C PGPV RI+ +F++  +PP    ++ GCIGGCD  L +  +I
Sbjct: 668 AEVTEEVCPHCQPGPVNRIRFQFKRGSVPPFIPNDYTGCIGGCDNNLMETLQI 720


>I0ZA53_9CHLO (tr|I0ZA53) DNA topoisomerase OS=Coccomyxa subellipsoidea C-169
           GN=COCSUDRAFT_11483 PE=3 SV=1
          Length = 919

 Score =  340 bits (873), Expect = 5e-91,   Method: Compositional matrix adjust.
 Identities = 180/425 (42%), Positives = 254/425 (59%), Gaps = 14/425 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +K+AEELYQ GFISYPRTETD F P  +L A+V+E      WG +AQR+   E  +W 
Sbjct: 323 RMMKLAEELYQEGFISYPRTETDVFDPAYDLKALVREHVNDARWGQHAQRIDSGE--MWA 380

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGES--GWSQNHRKLYELVVRHFLACVSKPAVGAETTVE 127
            PRGGGHDD AHPPIHPT++SA ++  GW  N R+LYE +VR FLA  SKPAVG ET VE
Sbjct: 381 APRGGGHDDHAHPPIHPTRWSAPDANQGWDPNKRRLYEFIVRSFLASCSKPAVGFETQVE 440

Query: 128 IDIAGELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPP 186
           + IA E F   G ++ E+N+++V+P+  WGG+  +P + V Q F PT L L  G+T+PPP
Sbjct: 441 VTIAAETFRTTGLMVKERNWMEVFPWARWGGNDNLPVFAVNQTFMPTELLLKDGMTQPPP 500

Query: 187 LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIE 246
            +SE DL+S M++ GIGTDAT+ DHI+K LDR YA KDA+  F+PT LGEALV  Y  + 
Sbjct: 501 KMSERDLISAMERHGIGTDATVADHIQKQLDRGYALKDAAQLFSPTALGEALVASYHKMG 560

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           ++  LW+P LR A+E ++  V+ G + K  VL  ++   +  ++ A   +  +LE +  F
Sbjct: 561 LS-NLWQPTLRGAIEHNITEVARGLRPKQEVLDEAVQHFRGDYIAAAGKQAMMLEEVGRF 619

Query: 307 FQRSNRSAGDELHAT----GEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWL 362
           F       G          G+ +  C  C   +++L +  +G   V C G P CR  V+ 
Sbjct: 620 FGPRAGGGGPGEAGGALPPGDPIGACASCG-LNLMLCQPAEGTPFVACSGAPLCRQRVYF 678

Query: 363 PGSVSEAAVTTNPCNFCT--PGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTE 420
           P     A ++  PC  C    G + +I  + R+  IPP +  + + C+  CD+  + L E
Sbjct: 679 PRPTLAADISDQPCATCQLDRGGLRKISFRLRRAAIPPGFEADMVACV-LCDQRFKDLCE 737

Query: 421 ICGTG 425
            CGT 
Sbjct: 738 ACGTA 742


>H2NSY8_PONAB (tr|H2NSY8) DNA topoisomerase (Fragment) OS=Pongo abelii GN=TOP3A
           PE=3 SV=1
          Length = 728

 Score =  336 bits (862), Expect = 9e-90,   Method: Compositional matrix adjust.
 Identities = 173/390 (44%), Positives = 239/390 (61%), Gaps = 11/390 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 344 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 400

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   + ++LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 401 RNGNKSDQAHPPIHPTKYTNSLQG---DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 457

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 458 QERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSRFQPSTVEMVDGETSPPKLLTEA 517

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++
Sbjct: 518 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDS--MGYEM 575

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LR+ +E+D+K + +G K K  VL   + K K  F+ A     K   A++ +F    
Sbjct: 576 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKYGRALAQYFGNGT 635

Query: 312 RSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
             A  E    A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+AVWLP SV EA
Sbjct: 636 ELAQQEEIYPAKPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEA 694

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPN 399
           +  ++ C  C P PVYRI     +  IPP+
Sbjct: 695 SRDSSVCPVCQPHPVYRISSSVTRGSIPPS 724


>G3NY56_GASAC (tr|G3NY56) DNA topoisomerase (Fragment) OS=Gasterosteus aculeatus
           GN=TOP3A PE=3 SV=1
          Length = 730

 Score =  331 bits (849), Expect = 3e-88,   Method: Compositional matrix adjust.
 Identities = 174/377 (46%), Positives = 232/377 (61%), Gaps = 11/377 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G+ISYPRTET+ F     L  +V++Q   P WG +AQR++D   G   NP
Sbjct: 315 MKIAEKLYTQGYISYPRTETNIFPTTLALGPLVEQQTQSPVWGTFAQRVIDQPGG--PNP 372

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK S+   G   N  +LYE +VRHFLACVS+ A+G ET V+IDIA
Sbjct: 373 RQGKKSDQAHPPIHPTKHSSTLQG---NEGRLYEFIVRHFLACVSQDALGQETVVDIDIA 429

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FS  G +I+ +NYLDVYP++ W   +IP Y  G QF P+A+ +  G T PP LL+EA
Sbjct: 430 QENFSTSGLMIIARNYLDVYPYDRWSAKVIPVYEQGSQFQPSAIEMADGQTSPPQLLTEA 489

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+ +  R Y    A  RF P  LG  LV GY+   M Y++
Sbjct: 490 DLISLMEKHGIGTDATHAEHIETIKSRMYVGLTADQRFLPGELGMGLVEGYNS--MGYEM 547

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K VSEG K K +VL   + K K  F+ +     KL EA+S +   + 
Sbjct: 548 SKPNLRAELEADLKLVSEGRKDKQSVLQNHIQKYKTVFIESVRKAKKLDEALSQYLGAAQ 607

Query: 312 RSAGDELHATGE--VVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSE 368
             A  E         VR+C  C++ DMVLKK R+GN   + C G+P C+ AVW P +V E
Sbjct: 608 EIAEAEQQDMEMPLPVRKCPNCRQ-DMVLKKKREGNGKYLSCSGYPACKTAVWFPDTVLE 666

Query: 369 AAVTTNPCNFCTPGPVY 385
            +   + C  C P PV+
Sbjct: 667 VSRDDSICPTCQPHPVH 683


>H2SSS7_TAKRU (tr|H2SSS7) DNA topoisomerase OS=Takifugu rubripes GN=LOC101078908
           PE=3 SV=1
          Length = 964

 Score =  324 bits (830), Expect = 5e-86,   Method: Compositional matrix adjust.
 Identities = 189/465 (40%), Positives = 260/465 (55%), Gaps = 64/465 (13%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F P   L  +V+EQ     WG +AQR+L+   G   NP
Sbjct: 266 MKIAEKLYTRGFISYPRTETNIFPPNLALGPLVEEQTQSSVWGAFAQRVLEQPGG--PNP 323

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK S+   G   N  +LYE +VRHFLACVS+ A+G ET V++DIA
Sbjct: 324 RQGKKSDQAHPPIHPTKHSSSLQG---NEGRLYEFIVRHFLACVSQDALGQETVVDVDIA 380

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FS  G +I  +NYLDVYP++ W   LIP Y  G QF PTA+ +  G T PP LL+EA
Sbjct: 381 QEKFSTSGLMITARNYLDVYPYDRWTTKLIPVYEQGSQFQPTAIEMVDGQTSPPQLLTEA 440

Query: 192 DLLSCMDKEGIGTDAT--MHD----HIKKLLDRFYATKDASTRFTPTNLGEALV------ 239
           DL++ M+K GIG   +  +H     HI+ +  R Y    +  RF P  LG  LV      
Sbjct: 441 DLIALMEKHGIGEVQSLFLHGCNPCHIETIKSRMYVGLTSDQRFLPGELGMGLVEGTHRC 500

Query: 240 ----------------MGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLD 283
                           +GY+   M Y++ KP LR+ +E+D+K VSEG K K +VL   + 
Sbjct: 501 IPAPERLVMQLFNHICLGYNS--MGYEMSKPNLRAELEADLKLVSEGRKDKWSVLQHHIQ 558

Query: 284 KMKACFLHARLNKVK----------LLEAMSIFFQ---RSNRSAGDELHATGEV------ 324
           K K  F+ + ++K K          LL   ++ F    R + +    L A  E+      
Sbjct: 559 KYKTVFIES-VHKAKKWVNIRTAGWLLTTTTVIFYCFLRLDEALSPYLGAAQEIPEEQQQ 617

Query: 325 -------VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSEAAVTTNPC 376
                  +R+C  C   DMVLKK R+GN   + C+G+P C+ AVW P  V E +   + C
Sbjct: 618 DMEIPLPIRKCPHCGR-DMVLKKKREGNGKYLTCVGYPACKTAVWFPDMVLEVSRDQSIC 676

Query: 377 NFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
             C P PV+ ++LKFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 677 PTCRPAPVHMLKLKFRRGSLPPMMPLEFVGCIGGCDETLREVLDL 721


>Q3TPE4_MOUSE (tr|Q3TPE4) Putative uncharacterized protein OS=Mus musculus
           GN=Top3a PE=2 SV=1
          Length = 694

 Score =  323 bits (828), Expect = 9e-86,   Method: Compositional matrix adjust.
 Identities = 165/354 (46%), Positives = 227/354 (64%), Gaps = 11/354 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++G  G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 405 RNGSKSDQAHPPIHPTKYTSGLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIA 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 522 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 579

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 580 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 639

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLP 363
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR+AVW P
Sbjct: 640 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECRSAVWFP 692


>M0WQP6_HORVD (tr|M0WQP6) Uncharacterized protein OS=Hordeum vulgare var.
           distichum PE=3 SV=1
          Length = 333

 Score =  321 bits (822), Expect = 5e-85,   Method: Compositional matrix adjust.
 Identities = 152/225 (67%), Positives = 181/225 (80%), Gaps = 3/225 (1%)

Query: 197 MDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPEL 256
           MDK GIGTDATMH+HIKKLLDR YATKDA++RF+PTNLGEALVMGYD  EM Y+LWKP L
Sbjct: 1   MDKAGIGTDATMHEHIKKLLDRCYATKDANSRFSPTNLGEALVMGYD--EMGYELWKPYL 58

Query: 257 RSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGD 316
           R+ ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKLL+AM  FF RSNR   +
Sbjct: 59  RAMMEADMKSVSVGTKSKAQVLEGCLQQMKACFLDARANKVKLLDAMGTFFARSNRPI-N 117

Query: 317 ELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPC 376
           E   T EVVR CG C ES+M+LK+  +G FMVGC GFPQCRN VWLPGSV+EAAVT   C
Sbjct: 118 ETQTTIEVVRPCGACNESEMLLKRRPNGGFMVGCRGFPQCRNVVWLPGSVAEAAVTQQIC 177

Query: 377 NFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
             C PGPVY+IQ KF + +IPP+++++HLGC+GGCD++L++LTE+
Sbjct: 178 PTCVPGPVYKIQFKFNRRDIPPSFDVDHLGCVGGCDDVLKELTEM 222


>H9JC36_BOMMO (tr|H9JC36) DNA topoisomerase OS=Bombyx mori PE=3 SV=1
          Length = 928

 Score =  320 bits (821), Expect = 5e-85,   Method: Compositional matrix adjust.
 Identities = 181/419 (43%), Positives = 240/419 (57%), Gaps = 23/419 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL  +V +Q G P WG +AQ++LD        P
Sbjct: 258 MQLAEKLYTQGFISYPRTETNEFPKEMNLAQLVGQQTGDPNWGTFAQKILDNGGP---TP 314

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   DKAHPPIHPTK++   SG   N ++LYE +VR FLAC SK A G ET V IDI 
Sbjct: 315 RQGKKSDKAHPPIHPTKYTNNLSG---NEKRLYEFIVRSFLACCSKDAQGQETIVNIDIG 371

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G VI E NYL+VY +E W    I  Y  GQ F+PT++ + SG T PP LL+EA
Sbjct: 372 REKFSANGLVITELNYLEVYIYEKWSSKEIHVYQEGQIFSPTSIDIVSGTTSPPSLLTEA 431

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S M+K GIGTDAT  +HI+K+  R Y        F P  LG  LV GYD   M  ++
Sbjct: 432 DLISLMEKHGIGTDATHAEHIEKIKSRSYVALADEKYFVPGVLGMGLVEGYD--AMGLEM 489

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +ESD+K + EG K  +AVL+  + K K  ++ A     K+  A++   +R N
Sbjct: 490 SKPHLRAQLESDLKEIIEGRKQPEAVLSEQIAKYKEVYIKASAEAEKIDRALA---ERLN 546

Query: 312 R------SAGDELHATGEVVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQCRNAVWLP 363
                  ++GD L        +C  C  SDM++  KKN    + +GC+ FP C+N VWLP
Sbjct: 547 EQPAAPPASGDTLPVDMPAALKCPKCG-SDMIVRQKKNNPTEYYIGCMSFPNCKNVVWLP 605

Query: 364 GSVSEAAVTTNPCNFCTPGPVYR-IQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
             V    V  + C  C  GP Y+ ++ ++R   I   Y   + GCIGGCD    +   I
Sbjct: 606 NIVKSLQVLPDTCTEC--GPDYKMMKFEWRNNSISHIYAPPYTGCIGGCDRTFLEYLNI 662


>J9K335_ACYPI (tr|J9K335) DNA topoisomerase OS=Acyrthosiphon pisum PE=3 SV=1
          Length = 839

 Score =  320 bits (821), Expect = 6e-85,   Method: Compositional matrix adjust.
 Identities = 172/414 (41%), Positives = 243/414 (58%), Gaps = 14/414 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    NL  +VQ       WG +AQ +L         P
Sbjct: 315 MKIAEKLYSQGFISYPRTETNIFPKELNLSNLVQLHVQDNNWGDFAQSVLINGP----TP 370

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++   +G     RK+YE VVRHFLAC+SK A G ET V I+I 
Sbjct: 371 RQGKKSDQAHPPIHPTKYT---NGLQDRERKVYEYVVRHFLACLSKDAEGEETIVNIEIN 427

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  I+  NYL+VYP++ W    I  Y  GQ F PT L +  G T PP LL+EA
Sbjct: 428 GEKFLANGLRIIALNYLEVYPYDKWSNKQIHNYDQGQSFMPTGLEIVDGQTSPPNLLTEA 487

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y   + +  F P  LG  LV GYD+  M +++
Sbjct: 488 DLISLMDKHGIGTDATHAEHIETIKSRLYVGLENNKYFVPGELGIGLVEGYDN--MGFEM 545

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K + EGTK    VL   + K K  F+       KL +++  + +   
Sbjct: 546 SKPHLRAELEADLKKICEGTKSPLVVLREQIAKYKDVFIKTTEQVEKLDQSLGKYLRTQP 605

Query: 312 RS-AGDELHATGEV--VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVS 367
            +   +  H +  V  +R+C +C+++++VLKK ++   F + C GFP CRN  WLP SV 
Sbjct: 606 VAFLNNAQHESMAVKNIRKCPVCKQTNLVLKKKQNNQGFFISCTGFPTCRNTYWLPPSVI 665

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +A V+ N C+ C+ G +  ++ +F    + P+Y   + GCI GCD  L ++ ++
Sbjct: 666 DAQVSDNICSECS-GGIKLVKFQFSARSMRPHYPDTYEGCINGCDSTLCEILQV 718


>I1FRL5_AMPQE (tr|I1FRL5) DNA topoisomerase OS=Amphimedon queenslandica PE=3 SV=1
          Length = 924

 Score =  319 bits (818), Expect = 1e-84,   Method: Compositional matrix adjust.
 Identities = 174/405 (42%), Positives = 235/405 (58%), Gaps = 14/405 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    +L ++++EQ     WG +A  +L     +   P
Sbjct: 323 MKIAEKLYTQGFISYPRTETNIFPESFDLVSLIREQTQDHRWGGFAGNVL----SVGPTP 378

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D AHPPIHP K++   +G   N ++LYE VVRHFLAC SK A G ETTVEI+I 
Sbjct: 379 RNGQKTDNAHPPIHPVKYTNSLTG---NEQRLYEFVVRHFLACCSKNAEGNETTVEIEIG 435

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G VI  +NYLDVY ++ W    +P Y +   F P+A+ +  G T PP LL EA
Sbjct: 436 GERFIAKGLVITARNYLDVYIYDKWADKTLPQYQLNGTFLPSAIEMIEGETNPPSLLQEA 495

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDK GIGTDAT  +HI+ +  R Y    +   F P  LG  LV GYD   M Y+L
Sbjct: 496 DLIALMDKHGIGTDATHAEHIETIKTRSYVGVQSDGSFVPGELGIGLVEGYDS--MGYQL 553

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS- 310
            KP+LR+ +E  +K + +G   KD V+   LDK K  F+ A+    KL  ++S +F  + 
Sbjct: 554 SKPKLRAELEDKLKRICDGYCTKDDVVREMLDKYKRVFVQAKQQARKLDLSLSKYFGEAR 613

Query: 311 --NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
             N     +     + VRRC  C+E DMV+K+ +DG +M+ CLGFP CR+  + P SV E
Sbjct: 614 DFNEQEQTQEPLLSDAVRRCPFCKEKDMVVKRKKDGGYMLSCLGFPHCRSLQFFPSSVIE 673

Query: 369 AAV-TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCD 412
           A    T  CN C P PV  +  KF++   P   +  + GC   CD
Sbjct: 674 AKPHPTQRCNNCYPPPVSYLSFKFQRGSTPHFMSDEYTGC-STCD 717


>Q4SVN5_TETNG (tr|Q4SVN5) DNA topoisomerase (Fragment) OS=Tetraodon nigroviridis
           GN=GSTENG00011897001 PE=3 SV=1
          Length = 984

 Score =  319 bits (817), Expect = 1e-84,   Method: Compositional matrix adjust.
 Identities = 183/469 (39%), Positives = 259/469 (55%), Gaps = 68/469 (14%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F     L ++V+EQ     WG +AQR+LD   G   +P
Sbjct: 266 MKIAEKLYTQGFISYPRTETNIFPKTLALGSLVEEQTQSSVWGTFAQRVLDQPGG--PSP 323

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPT+ S+   G   N  +LYE +VRHFLACVS+ A+G ET V++DIA
Sbjct: 324 RQGKKSDQAHPPIHPTRHSSSLQG---NEGRLYEFIVRHFLACVSQDALGQETVVDVDIA 380

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G +I+ +NYLDVYP++ W   +IP Y  G QF PTA+ +  G T PP LL+EA
Sbjct: 381 QEKFSASGLMIIARNYLDVYPYDRWSTKVIPVYEQGSQFQPTAIEMVDGQTSPPQLLTEA 440

Query: 192 DLLSCMDKEGIGTDATMH-------DHIKKLLDRFYATKDASTRFTPTNLGEALV----- 239
           DL++ M+K GIG    +         HI+ +  R Y    +  RF P  LG  LV     
Sbjct: 441 DLIALMEKHGIGRLQWLFLHGCNPCGHIETIKSRMYVGLTSDQRFLPGELGMGLVEGAYA 500

Query: 240 -------------------MGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLAT 280
                              +GY+   M Y++ KP LR+ +E+D+K VSEG K K +VL  
Sbjct: 501 LRGTKTGLVWLVQMLTRIGLGYNS--MGYEMSKPNLRAELEADLKLVSEGRKDKRSVLGH 558

Query: 281 SLDKMKACFLHARLN------------------------KVKLLEAMSIFFQRSNRSAGD 316
            + K K  F+ +                            ++L EA+S +   + +   +
Sbjct: 559 HIQKYKTVFIESVQKAKKWVVVTDVGQTEAGMLSDLVCCSLRLDEALSPYLG-AAQEITE 617

Query: 317 ELHATGEV---VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSEAAVT 372
           E     E+   VR+C  C   DMVLKK R+GN   + C+G+P C++AVW P +V E +  
Sbjct: 618 EQQQDMEIPLPVRKCPHCGR-DMVLKKKREGNGKYLTCVGYPACKSAVWFPDTVLEVSRD 676

Query: 373 TNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            + C  C P PV+ ++ KFR+  +PP   +  +GCIGGCDE LR++ ++
Sbjct: 677 ESVCPTCQPAPVHMLKFKFRRGSLPPVMPLEFVGCIGGCDETLREVLDL 725


>A7S883_NEMVE (tr|A7S883) Predicted protein (Fragment) OS=Nematostella vectensis
           GN=v1g108642 PE=3 SV=1
          Length = 940

 Score =  316 bits (809), Expect = 1e-83,   Method: Compositional matrix adjust.
 Identities = 169/418 (40%), Positives = 244/418 (58%), Gaps = 23/418 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G  S   TET +F+   ++ + ++   G      +A  +L        NP
Sbjct: 315 MKIAEKLYTQGRYSVTGTETTTFNAVESMISYIEFVTG------FASDVL----ANGPNP 364

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D AHPPIHPT+++    G   N ++LYE +VRHFLAC S+ A G ET+VEIDIA
Sbjct: 365 RQGSKTDNAHPPIHPTQYTNNLQG---NDKRLYEFIVRHFLACCSQDAQGRETSVEIDIA 421

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A G +I  +NYLDVYP++ W   +IP Y   ++F PT++ +  G T PPPLL+EA
Sbjct: 422 GEKFTATGLMITARNYLDVYPYDRWSTKVIPVYETNEEFQPTSIEMVDGETTPPPLLTEA 481

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  DHI+ +  R Y        F P  LG  LV GYD   M ++ 
Sbjct: 482 DLIALMEKHGIGTDATHADHIETIKSRSYVGVQGDGTFLPGQLGMGLVEGYD--LMHFEF 539

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP+LRS +E+D+K + +GTK    VL   + K K  F+ A    +KL +A+S +F    
Sbjct: 540 SKPKLRSGLEADLKRICDGTKSGAVVLREQIAKYKENFIQAAQEAIKLDQALSNYFGDPA 599

Query: 312 RSAGDELH--ATGEVVRRCGLCQESDMVLKKNRDGN------FMVGCLGFPQCRNAVWLP 363
                EL   A   +VR C  C++  M L+K ++G       +M+GC GFPQCR +++LP
Sbjct: 600 DFIEQELDPLAADPIVRPCPRCEQHQMTLRKTKEGRQVKLSFYMIGCQGFPQCRASIFLP 659

Query: 364 GSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            SV    V  + C  C P  V+ ++  F++  +PP   + ++GCIGGCDE+L +  +I
Sbjct: 660 KSVLALTVDESVCPVCRPRDVHMLRFTFKRGSVPPMTPLQYVGCIGGCDEMLTETLDI 717


>K7IZC3_NASVI (tr|K7IZC3) DNA topoisomerase OS=Nasonia vitripennis PE=3 SV=1
          Length = 1078

 Score =  315 bits (808), Expect = 2e-83,   Method: Compositional matrix adjust.
 Identities = 175/415 (42%), Positives = 243/415 (58%), Gaps = 17/415 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL  +VQ+Q  + +WG +AQR+LD   G+   P
Sbjct: 316 MQIAEKLYTGGFISYPRTETNIFPKEMNLSTLVQQQTANGDWGGFAQRVLD--EGI--TP 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTKF+    G   N  ++YE VVRHFLAC+SK A G ET VEIDIA
Sbjct: 372 RQGKKSDQAHPPIHPTKFTDTLRG---NEARVYEYVVRHFLACLSKNAEGHETIVEIDIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  IL KNYL+V+ +E W    I  Y  GQ F PT++ +    T PP LL+EA
Sbjct: 429 GEKFVATGLQILAKNYLEVFIYEKWNAKEIHIYERGQTFMPTSIEMLEETTSPPNLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDK GIGTDAT  +HI+ +  R Y     +    P  LG  LVMGYD   M +++
Sbjct: 489 DLIALMDKHGIGTDATHAEHIETIKSRQYVGLRDNKYLIPGKLGIGLVMGYD--RMGFQM 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K + +G K  D V  + ++K +  F  A L K  +++A    +    
Sbjct: 547 SKPHLRAELENDLKLICDGVKTPDEVRQSMINKYREVFREA-LVKANMIDAALAQYLDEQ 605

Query: 312 RSAGDELHATGEV----VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSV 366
             A ++      V    + RC  C  S+MV+K  R GN   +GC+G+P C N +WLP SV
Sbjct: 606 PEAIEQADIAVPVEDVPILRCPKCN-SNMVVKTKRQGNGKYIGCMGYPTCNNVIWLPESV 664

Query: 367 SEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            E  +    CN C    + +I+++  +  I P +  ++  CIGGCD++   L  I
Sbjct: 665 EEVEILDEGCNQCPDNILKKIKVRLTR-NIFPQFGTSYTACIGGCDDMFNNLMGI 718


>H2Z236_CIOSA (tr|H2Z236) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 970

 Score =  315 bits (807), Expect = 2e-83,   Method: Compositional matrix adjust.
 Identities = 184/463 (39%), Positives = 252/463 (54%), Gaps = 70/463 (15%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 272 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGGP--QP 329

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 330 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 386

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T   PLL+EA
Sbjct: 387 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRT-TAPLLTEA 445

Query: 192 DLLSCMDKEGIG--------TDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMG-- 241
           DL+S MDK GIG        TDAT  +HI+ +  R Y       RF P  LG  LV G  
Sbjct: 446 DLISLMDKHGIGLFLFPTLCTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGGI 505

Query: 242 ------------------------YDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAV 277
                                   YD   M Y + +PELR+ +E+D++ + +GT  K+ V
Sbjct: 506 RFIARQAKKPLASLVLLDSLIGKRYD--LMGYAMSRPELRAELEADLRRICDGTANKNDV 563

Query: 278 LATSL--------------DKMKACFLHARLN----KVKLLEAMSIFFQRSNRSAGDEL- 318
           L   +              DK    FL   +N      +L EA+S +F  + R  G  L 
Sbjct: 564 LQRHISTYRSVFQEAIQKADKWVWVFLQIEINFHFESHRLDEALSAYFGDATRVEGSNLL 623

Query: 319 --HATGEVVRRCGLCQESDMVLKKNRDG------NFMVGCLGFPQCRNAVWLPGSVSEAA 370
                   VR C  C + DM+LKK RDG      +FM+ C G+P CRNA++LP SV +  
Sbjct: 624 NPSGASPPVRPCPRCGK-DMILKKKRDGGLTSPHSFMLSCTGYPNCRNALFLPSSVLDIT 682

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDE 413
           V ++ C  C P PV+++ +K     IP  ++ + + CIGGCD+
Sbjct: 683 VDSSVCPNCQPSPVHQVNVKLNPRSIPAYFSSDQIICIGGCDD 725


>B4FWE9_MAIZE (tr|B4FWE9) Uncharacterized protein OS=Zea mays PE=2 SV=1
          Length = 404

 Score =  315 bits (807), Expect = 2e-83,   Method: Compositional matrix adjust.
 Identities = 153/231 (66%), Positives = 177/231 (76%), Gaps = 3/231 (1%)

Query: 197 MDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPEL 256
           MDK GIGTDATMHDHIKKLLDR YATKD +TRF+PTNLGEALVMGYD  EM Y+LWKP L
Sbjct: 1   MDKAGIGTDATMHDHIKKLLDRCYATKDENTRFSPTNLGEALVMGYD--EMGYELWKPYL 58

Query: 257 RSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGD 316
           RS ME+DMKSVS GTK K  VL + L +MKACFL AR+ K KLL+AM  FF RSNR   +
Sbjct: 59  RSMMEADMKSVSVGTKSKSEVLESCLQQMKACFLDARVKKAKLLDAMGTFFARSNRPI-N 117

Query: 317 ELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPC 376
           E     EVVR CG C  S+M+LK+   G FMVGC  +PQCRN VWLPGS+SEAAVT   C
Sbjct: 118 ETQNPVEVVRPCGACNGSEMLLKRRASGEFMVGCRSYPQCRNVVWLPGSLSEAAVTNQVC 177

Query: 377 NFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPR 427
             C PGPVY+IQ KFR+ +IPPN++++HLGC+GGCD+IL+ L EI   G R
Sbjct: 178 PICAPGPVYKIQFKFRRRDIPPNFDVDHLGCVGGCDDILKDLMEISRFGSR 228


>K1QMX0_CRAGI (tr|K1QMX0) DNA topoisomerase OS=Crassostrea gigas GN=CGI_10006872
           PE=3 SV=1
          Length = 1950

 Score =  315 bits (806), Expect = 3e-83,   Method: Compositional matrix adjust.
 Identities = 169/417 (40%), Positives = 236/417 (56%), Gaps = 40/417 (9%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTET+ F    +L A+VQEQ   P WG +A  +L        NP
Sbjct: 266 MRIAENLYTKGFISYPRTETNIFPKDLDLAALVQEQSRDPNWGGFASGILQDRP----NP 321

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHP K++A   G   N  +LYE +VRHFLA  SK A G ETTV I+IA
Sbjct: 322 RNGNKSDQAHPPIHPIKYTATLQG---NDARLYEFIVRHFLATCSKDAQGQETTVTINIA 378

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E+F+A G +I+ +NYLDVYP++ W    IP Y  G  F P ++ +    T PPPLL+EA
Sbjct: 379 DEMFTAQGLMIIARNYLDVYPYDRWNAKTIPVYQEGDSFQPNSIDMLFSETSPPPLLTEA 438

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y   +   RF P  LG  LV GYD   M Y++
Sbjct: 439 DLIALMEKHGIGTDATHAEHIETIKTRMYIGVNNDGRFVPGQLGMGLVEGYD--AMGYEM 496

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LRS +E+D+K + EG K K+ VL   + K +  F  A    +K+ +A+S +   + 
Sbjct: 497 SKPHLRSELEADLKRICEGKKDKNVVLTQQVAKYRDVFKVACEQALKIDQALSQYLGEAK 556

Query: 312 R-SAGDELHATGEV-VRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
               G+EL     V V++C  C   +M LK  + G F +GC G+P CR+A+W P  V +A
Sbjct: 557 EIPVGEELERLSVVPVKKCSNCG-LEMTLKTKKSGGFYIGCQGYPSCRSAIWFPDFVLDA 615

Query: 370 AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGP 426
           +V+                            ++ + GC+ GCDE+L +  +I  + P
Sbjct: 616 SVS----------------------------DVKYAGCVAGCDELLAESLQINHSAP 644


>B0QZI1_MOUSE (tr|B0QZI1) DNA topoisomerase 3-alpha OS=Mus musculus GN=Top3a PE=2
           SV=1
          Length = 670

 Score =  312 bits (799), Expect = 2e-82,   Method: Compositional matrix adjust.
 Identities = 161/348 (46%), Positives = 222/348 (63%), Gaps = 11/348 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL A+V++Q   P WG +AQ +L+        P
Sbjct: 323 MRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGP---TP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+++G  G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA
Sbjct: 380 RNGSKSDQAHPPIHPTKYTSGLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIA 436

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   L+P Y  G  F P+ + +  G T PP LL+EA
Sbjct: 437 QERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEA 496

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++
Sbjct: 497 DLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEM 554

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP+LR+ +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+
Sbjct: 555 SKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERT 614

Query: 311 NRSAGDELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCR 357
             +  +E++ A  E VR+C  C + DMVLK  + G F + C+GFP+CR
Sbjct: 615 EMAQQEEIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCMGFPECR 661


>D4A6J4_RAT (tr|D4A6J4) Protein Top3a OS=Rattus norvegicus GN=Top3a PE=2 SV=2
          Length = 1003

 Score =  312 bits (799), Expect = 2e-82,   Method: Compositional matrix adjust.
 Identities = 158/343 (46%), Positives = 221/343 (64%), Gaps = 8/343 (2%)

Query: 78  DKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIAGELFSA 137
           D    PIHPTK+++   G   + R+LYE +VRHFLAC S+ A G ETTVEIDIA E F A
Sbjct: 411 DGTQIPIHPTKYTSSLQG---DDRRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 467

Query: 138 CGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEADLLSCM 197
            G +IL +NYLDVYP++ W   L+P Y  G +F P+ + +  G T PP LL+EADL++ M
Sbjct: 468 HGLIILARNYLDVYPYDHWSDKLLPVYEQGFRFQPSTVEMVDGETSPPQLLTEADLIALM 527

Query: 198 DKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPELR 257
           +K GIGTDAT  +HI+ +  R Y    +  RF P +LG  LV GYD   M Y++ KP LR
Sbjct: 528 EKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDS--MGYEMSKPNLR 585

Query: 258 SAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRSNRSAGD 316
           + +E+D+K + EG K K  VL   + K K  F+ A     KL EA+S +  +R+  +  +
Sbjct: 586 AELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERTEVAQQE 645

Query: 317 ELH-ATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNP 375
           E++ A  E VR+C  C + DMVLK  + G F + C GFP+CR+AVW P SV EA+  ++ 
Sbjct: 646 EIYPAMPEPVRKCPQCNK-DMVLKTKKSGGFYLSCTGFPECRSAVWFPDSVLEASRDSSV 704

Query: 376 CNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQL 418
           C+ C P PVYR++LKF++  +PP+  +  +GCIGGCDE L+++
Sbjct: 705 CSVCQPAPVYRLKLKFKRGSLPPSMPLEFVGCIGGCDETLKEI 747


>F2UQ44_SALS5 (tr|F2UQ44) DNA topoisomerase OS=Salpingoeca sp. (strain ATCC
           50818) GN=PTSG_10697 PE=3 SV=1
          Length = 1137

 Score =  304 bits (779), Expect = 5e-80,   Method: Compositional matrix adjust.
 Identities = 170/388 (43%), Positives = 224/388 (57%), Gaps = 12/388 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           L  AE LYQ G ISYPRTETD F    NL  +V+    H EWG +AQ L+ P      +P
Sbjct: 273 LSTAESLYQKGLISYPRTETDMFDKSINLTRLVENLTAHTEWGAFAQTLVPPNGAP--SP 330

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G + D+AHPPIHPTK  A  +  S   RK+YELV RHFLACVS+ A G ETTV I  A
Sbjct: 331 RNGRNTDEAHPPIHPTKNIAPAALASDKERKIYELVCRHFLACVSRNAKGRETTVTITAA 390

Query: 132 GELFSACGRVILEKNYLDVY-PFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           GE F A G  I ++ YL+VY PF++W G +IP Y+VGQQF P    + SG T  P LLSE
Sbjct: 391 GETFVAKGLAIHDRGYLEVYHPFDSWKGKMIPDYSVGQQFEPD-FQMQSGETVAPKLLSE 449

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADLL+ M K  IGTDATM +HI+ +  R Y          PT LG ALV GYD +     
Sbjct: 450 ADLLTLMAKYEIGTDATMAEHIRTIQQRHYVELTPQRELVPTTLGIALVNGYDAMSFTIS 509

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           + +P+LR  ME++MK +  G   KD V+   ++K +  F   +    KL  AM+      
Sbjct: 510 VSRPDLRREMEANMKRICRGQISKDDVIRDGIEKYRNVFSVVKREVHKLDAAMAEQLGPP 569

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
           N   G+   A    VRRC  C ++D VL++   G +M+GC  +P CR +VWL  +++E A
Sbjct: 570 NGRPGEVPVA----VRRCPACNQADQVLRRTAQGKYMIGCTRYPACRASVWLQ-NLAECA 624

Query: 371 VTTNPCNFCTPGPVYRIQLKFRQLEIPP 398
           V  + C  C      ++++KF+   +PP
Sbjct: 625 VDADTCARCG---ATKLKMKFKPNTLPP 649


>H9HDQ6_ATTCE (tr|H9HDQ6) DNA topoisomerase OS=Atta cephalotes PE=3 SV=1
          Length = 1033

 Score =  303 bits (777), Expect = 8e-80,   Method: Compositional matrix adjust.
 Identities = 169/414 (40%), Positives = 238/414 (57%), Gaps = 18/414 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTET+ F    NL ++V++Q  + EWG +AQ LL  E+G+   P
Sbjct: 316 MRIAERLYTQGFISYPRTETNIFPKELNLRSLVEQQINNQEWGNFAQNLL--ESGI--TP 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHP K++    G   N  K+YE VVRHFLAC+SK A G ETTVEIDIA
Sbjct: 372 RQGKKSDQAHPPIHPIKYTDNLYG---NEAKVYEFVVRHFLACLSKNAEGRETTVEIDIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  I+ KNYLDVY +E W    I +Y   Q F PT++ +    T  P LL+EA
Sbjct: 429 GEKFKANGLEIITKNYLDVYIYEKWSNKQIHSYEQRQVFRPTSIDMVEEKTSAPNLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L++ MDK GIGTDAT  DHI  +  R Y     +  F P  LG  LVMGYD+  M +++
Sbjct: 489 ELIALMDKHGIGTDATHADHIDTIKSRQYVGLTDTQHFMPGKLGIGLVMGYDN--MGFQM 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E D++ + E  K  + VL   ++K +  F  A + +  L++     +    
Sbjct: 547 SKPHLRADLEKDLQLICESKKNPNEVLQNQINKYREVFQVA-IERANLIDDSLAHYLNER 605

Query: 312 RSAGDELHATGEVVR---RCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVS 367
               +++     V+    +C  C  SDMVLK+ R G    + C G+P+C N +W P +V 
Sbjct: 606 PLQTEQIQLNTPVISTIFKCPKCG-SDMVLKQRRQGRGKYITCTGYPECTNVIWFPETVE 664

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  V    CN CT   +++++ K  +  + P Y  +H  CI GCD I  ++  I
Sbjct: 665 DVEVLNETCNRCTEN-IHKLKFKLVR-NVIPMYGTSHTTCI-GCDTIFNEMLNI 715


>F4X1K5_ACREC (tr|F4X1K5) DNA topoisomerase OS=Acromyrmex echinatior GN=G5I_12166
           PE=3 SV=1
          Length = 1005

 Score =  303 bits (777), Expect = 8e-80,   Method: Compositional matrix adjust.
 Identities = 169/414 (40%), Positives = 239/414 (57%), Gaps = 18/414 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTET+ F    NL ++V++Q  + EWG +AQ LL  E+G+   P
Sbjct: 266 MRIAERLYTQGFISYPRTETNIFPKELNLRSLVEQQVNNQEWGNFAQNLL--ESGI--TP 321

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHP K++    G   N  K+YE VVRHFLAC+SK A G ETTVEIDIA
Sbjct: 322 RQGKKSDQAHPPIHPIKYTDNLYG---NEAKVYEFVVRHFLACLSKNAEGRETTVEIDIA 378

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  I+ KNYLDVY +E W    I +Y   Q F PT++ +    T  P LL+EA
Sbjct: 379 GEKFKANGLEIITKNYLDVYIYEKWNNKQIHSYEQRQVFRPTSIDMVEEKTSAPNLLTEA 438

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L++ MDK GIGTDAT  DHI  +  R Y     +  F P  LG  LVMGYD+  M +++
Sbjct: 439 ELIALMDKHGIGTDATHADHIDTIKSRQYVGLTDTQHFMPGKLGIGLVMGYDN--MGFQM 496

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E D++ + E  K  + VL + ++K +  F  A + +  L++     +    
Sbjct: 497 SKPHLRADLEKDLQLICESKKNPNEVLQSQINKYREVFQVA-IERANLIDDSLAHYLDER 555

Query: 312 RSAGDELHATGEVVR---RCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVS 367
               +++     V+    +C  C  S MVLK+ R G    + C+G+P+C N +W P +V 
Sbjct: 556 PLQTEQIQLNTPVISTIFKCPKCG-SGMVLKQRRQGRGKYITCMGYPECTNVIWFPEAVE 614

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           +  V    CN CT   +Y+++ K  +  + P Y  +H  CI GCD I  ++  I
Sbjct: 615 DVEVLNETCNQCTEN-IYKLKFKLVR-NVIPMYGTSHTTCI-GCDTIFNEMLNI 665


>H9K4U5_APIME (tr|H9K4U5) DNA topoisomerase OS=Apis mellifera GN=LOC410571 PE=3
           SV=1
          Length = 1012

 Score =  302 bits (773), Expect = 2e-79,   Method: Compositional matrix adjust.
 Identities = 165/417 (39%), Positives = 238/417 (57%), Gaps = 18/417 (4%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +++AE+LY  G ISYPRTET+ F    NL ++V +Q  +P WG +AQ+LL  E G+  
Sbjct: 314 EIMRIAEKLYTQGLISYPRTETNIFPKELNLISLVNQQINNPAWGNFAQQLL--EKGV-- 369

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           NPR G   D+AHPPIHP K+    +G   N  K+YE VVRHFLAC+S  A+G +  VEID
Sbjct: 370 NPRKGKKSDQAHPPIHPIKYCDNLNG---NEAKVYEFVVRHFLACLSSNAIGHQVIVEID 426

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE F+A G  ++EKNYLDVY +E W    I  Y  GQ F PT++ +    T PP LL+
Sbjct: 427 IAGEKFNANGLQVIEKNYLDVYIYEKWNEQKIHNYREGQVFKPTSIEMIEEKTSPPQLLT 486

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EADL++ MDK GIGTDAT  +HI  +  R Y          P  LG  LV+GYD+  M +
Sbjct: 487 EADLITLMDKHGIGTDATHAEHIDTIKSRQYVGLVDEKYLIPGKLGIGLVLGYDN--MGF 544

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLE-AMSIFFQ 308
           ++ KP LR+ +E D+K + E  K    VL   ++K +  F    + +  L++ A++ +F 
Sbjct: 545 QMSKPGLRAELERDLKLICEQRKNAKEVLENQINKYRDLF-KISMERANLIDNALADYFD 603

Query: 309 RSN---RSAGDELHATGEVVRRCGLCQESDMVLKKNRDG-NFMVGCLGFPQCRNAVWLPG 364
                 +   +   +    + +C  C   DM LK  + G    +GC+G+P C N +W P 
Sbjct: 604 EQPTKIQELENNFPSQDIAIFKCPKCG-LDMTLKDRKQGMGKYIGCIGYPTCNNVIWFPQ 662

Query: 365 SVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
            + +  +T N C+ C PG ++ ++ K R+   P  Y  ++  CIGGCD    +L  I
Sbjct: 663 YIEDVEITDNICSRC-PGNIHELKFKLRKNAYPI-YGTDYKTCIGGCDPTFNELLNI 717


>G7JC54_MEDTR (tr|G7JC54) DNA topoisomerase OS=Medicago truncatula
           GN=MTR_3g096630 PE=4 SV=1
          Length = 432

 Score =  301 bits (770), Expect = 5e-79,   Method: Compositional matrix adjust.
 Identities = 140/182 (76%), Positives = 153/182 (84%)

Query: 249 YKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQ 308
           YKLWKP+LR+ ME DMKSVSEG K K  VL TSL +MK CFL ARLNKVKLLEAM+IFF+
Sbjct: 36  YKLWKPDLRAVMERDMKSVSEGNKSKAEVLDTSLQQMKTCFLDARLNKVKLLEAMAIFFE 95

Query: 309 RSNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           R NR   DE + TG VVRRC LCQESDMVLKKNRDGNFMVGC  +PQCR+ VWLPGS+SE
Sbjct: 96  RLNRVGSDEQNGTGVVVRRCRLCQESDMVLKKNRDGNFMVGCRSYPQCRSVVWLPGSISE 155

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTGPRM 428
           A VTTN CN CTPGPVY IQ KF+QL+IPP+YN+NHLGCIGGCDEIL QLTEICGTG RM
Sbjct: 156 AVVTTNACNNCTPGPVYLIQFKFQQLKIPPSYNVNHLGCIGGCDEILTQLTEICGTGSRM 215

Query: 429 PG 430
           P 
Sbjct: 216 PA 217


>N6UAY1_9CUCU (tr|N6UAY1) Uncharacterized protein (Fragment) OS=Dendroctonus
           ponderosae GN=YQE_05695 PE=4 SV=1
          Length = 753

 Score =  299 bits (766), Expect = 1e-78,   Method: Compositional matrix adjust.
 Identities = 172/417 (41%), Positives = 245/417 (58%), Gaps = 19/417 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+SF    NL  +V++QQ   +WG +A+R++  E G    P
Sbjct: 315 MKIAEKLYTQGFISYPRTETNSFPKELNLANLVEQQQNDNQWGPFARRVM-AEGG--PTP 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N +++YE +VRHFLACV K A G ET V +DIA
Sbjct: 372 RQGKKSDQAHPPIHPTKYADNLQG---NEKRVYEYIVRHFLACVHKDAQGFETVVNVDIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A G +ILEKNYLDVY +E W    I  Y  G  F PT L L    T PP LL+EA
Sbjct: 429 GEKFTAKGLIILEKNYLDVYIYEKWNAKEINNYEQGDTFDPTVLELVESKTAPPKLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI  +  R Y        F P NLG  LV GY+DI +   L
Sbjct: 489 DLIALMEKHGIGTDATHAEHIDTIKSREYVGLH-DIYFVPGNLGMGLVEGYNDIGLEVSL 547

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLE-AMSIFFQRS 310
            KP LR+  E D+K + +G K  + V    ++K KA F+     K++L++ +++      
Sbjct: 548 AKPTLRADFEKDLKLICDGLKNPEVVRREQVEKYKAVFMTV-AEKMRLIDNSLANRLDDR 606

Query: 311 NRSAGDELHA-TGEVVR---RCGLCQESDMVLKKNRDGNF-MVGCLGFPQCRNAVWLPGS 365
            ++  D + A  G+  +   +C  C + DM+++  ++G+   + CLG+P C+N+ W P  
Sbjct: 607 PQNVPDAVVAGNGQDFKPALKCPKCGQ-DMIVRTKKNGSSKFLSCLGYPDCKNSAWFPSM 665

Query: 366 VSEAAVTTNPCNFCTPGPVYR-IQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           V    VT   C  C  GP ++ +++ FR    P   N N++ CIGGCD  + ++  I
Sbjct: 666 VKNIDVTDEYCPEC--GPDFKLLRITFRPNPFPGEPNPNNV-CIGGCDPNVIEMLNI 719


>Q171C3_AEDAE (tr|Q171C3) DNA topoisomerase OS=Aedes aegypti GN=AAEL007683 PE=3
           SV=1
          Length = 1021

 Score =  298 bits (764), Expect = 3e-78,   Method: Compositional matrix adjust.
 Identities = 177/427 (41%), Positives = 247/427 (57%), Gaps = 36/427 (8%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR-N 70
           + +AE+LY  G ISYPRTET+ F+    L  +V+ Q  +PEWG +AQ++L      W  N
Sbjct: 339 MTIAEKLYTQGIISYPRTETNMFTNDMKLAPLVEMQTDNPEWGGFAQKVLQ-----WGPN 393

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK+ +  +G   + +++YELVVRHFLAC+SK AVG+ET V   +
Sbjct: 394 PRNGKKSDQAHPPIHPTKYVSNLTG---DEKRIYELVVRHFLACISKDAVGSETVVNAVL 450

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           A E F+A G  ILE+NYL+VYP++ W    I  Y VG  F PT L+L  G T  P +L+E
Sbjct: 451 ADEEFTASGLCILERNYLEVYPYDRWNSREIHPYQVGHTFEPTELSLHQGSTTAPNMLTE 510

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y  +       P  LG  LV GY+ +E+   
Sbjct: 511 ADLIALMEKHGIGTDATHAEHINTIKERGYIGEAEGRYLVPGTLGMGLVEGYEAMELT-- 568

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L +PELR+ +E+D+K + EG K    VLA  + K K  +         L +AMS   QR 
Sbjct: 569 LAQPELRAGLEADLKLICEGRKDPKVVLAEQIQKYKEAYRVITQKARALDQAMS---QRL 625

Query: 311 NRSAGD----ELHATG----EVVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVW 361
           N +  D    +  +TG    + V +C  C +  M LKK +DGN + +GCLGFP CRN VW
Sbjct: 626 NEAPKDAPTNQFASTGNNPLQEVCKCPKCSQM-MALKKKKDGNSYYLGCLGFPDCRNTVW 684

Query: 362 LPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYN-INHLG------CIGGCDEI 414
              ++ EA+ T   C  C  G   ++ +KF+Q+     Y  +NH+       CI  CD  
Sbjct: 685 FDENIKEASGTDEICPRCG-GSNKKMTIKFKQIRF---YGLLNHMSADAYKTCI-VCDNK 739

Query: 415 LRQLTEI 421
            R++  I
Sbjct: 740 FREVLGI 746


>B0WGC0_CULQU (tr|B0WGC0) DNA topoisomerase OS=Culex quinquefasciatus
           GN=CpipJ_CPIJ006288 PE=3 SV=1
          Length = 992

 Score =  296 bits (758), Expect = 1e-77,   Method: Compositional matrix adjust.
 Identities = 170/416 (40%), Positives = 241/416 (57%), Gaps = 22/416 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR-N 70
           + +AE+LY  G ISYPRTET+ F+    L  +V+ Q GHPEWG +AQ+++      W  N
Sbjct: 315 MTIAEKLYTQGIISYPRTETNMFTHDMKLAPLVEMQAGHPEWGDFAQKVMQ-----WGPN 369

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTKF    SG   + +++YELVVRHFLACVSK AVGAET V   +
Sbjct: 370 PRNGKKSDQAHPPIHPTKFVTNLSG---DEKRVYELVVRHFLACVSKDAVGAETIVNAVL 426

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           A E F+A G  ILE+NYL+VYP++ W    I  Y +G  F PT L L  G T  P +L+E
Sbjct: 427 AEEEFTASGLCILERNYLEVYPYDRWNSKEIHAYQMGNTFEPTELGLHEGSTTAPNMLTE 486

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y  +       P  LG  LV GY+ +E+   
Sbjct: 487 ADLIALMEKHGIGTDATHAEHINTIKERGYIGEADRGFLVPGTLGMGLVEGYESMELP-- 544

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L +P+LR+ +E D+K + EG +    VL   + K K  +         L +AM    Q++
Sbjct: 545 LAQPKLRAGLEEDLKRICEGQRDPKVVLQEQIQKYKEAYRVITEKARALDQAMGQRLQQT 604

Query: 311 NRSA-GDELHATG----EVVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPG 364
            R A  ++ +A G    + V +C  C +  M LK  +D + + +GCLGFP C+N+VW   
Sbjct: 605 PRDAPTNQFNAAGPSSIQEVCKCPKCSQM-MCLKTKKDNSGYYLGCLGFPDCKNSVWFDD 663

Query: 365 SVSEAAVTTNPCNFCTPG-PVYRIQLKFRQLEIPPNY--NINHLGCIGGCDEILRQ 417
           ++ EA+ TT  C+ C  G     ++ KF +     N+  N ++  CI  CD+  R+
Sbjct: 664 NIKEASATTEVCSKCATGNKKLEVKFKFSRYYAMLNHTNNESYKTCI-VCDDKFRE 718


>B4PAZ8_DROYA (tr|B4PAZ8) DNA topoisomerase OS=Drosophila yakuba GN=Dyak\GE13263
           PE=3 SV=1
          Length = 1229

 Score =  293 bits (751), Expect = 7e-77,   Method: Compositional matrix adjust.
 Identities = 170/397 (42%), Positives = 226/397 (56%), Gaps = 34/397 (8%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLW-RN 70
           + VAE+LY  GFISYPRTET+ FS    L  +V+ Q GH +WG +AQR+++     W  N
Sbjct: 317 MTVAEKLYSKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK +    G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPTKLAENLQG---NEARVYELVVRHFLACVSKDAVGSETLVHIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE F+A G VI E+NYLDVY +E W    I  Y  GQ+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFTANGLVIHERNYLDVYVYEKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+   
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELT-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF-------------LHARLNKV 297
           L KP+LR+  ESD+K + +G K    VL   + K K  +             + AR+N+ 
Sbjct: 547 LAKPKLRAEFESDLKLICQGQKDPKIVLTEQIAKYKQSYQQITEKITAMDAKISARINET 606

Query: 298 KLLEAMSIFFQRSNRSAGDELHATGEVVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQ 355
               +      +     G     T + + +C  C E+ + L  KKN+ G + +GC  FP 
Sbjct: 607 PTANSSG----QVGEDGGGPSQGTMQSIFQCPKCNEAPLALKPKKNQQG-WYIGCNNFPD 661

Query: 356 CRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           C+N VWLP    + +V +  C  C  G  YR+ LKFR
Sbjct: 662 CKNVVWLPTECKDVSVLSECCPTCGDG--YRM-LKFR 695


>E2A6W4_CAMFO (tr|E2A6W4) DNA topoisomerase OS=Camponotus floridanus GN=EAG_02503
           PE=3 SV=1
          Length = 1044

 Score =  293 bits (749), Expect = 1e-76,   Method: Compositional matrix adjust.
 Identities = 164/413 (39%), Positives = 241/413 (58%), Gaps = 16/413 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  GFISYPRTET+ F    NL  +V++Q  H  WG +A+ LL  E+G+   P
Sbjct: 316 MRIAEKLYTQGFISYPRTETNIFPKELNLVPLVEQQVNHEAWGDFARGLL--ESGI--TP 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N  ++YE +VRHFLAC+SK A G ETTVEIDIA
Sbjct: 372 RQGKKSDQAHPPIHPTKYTDSLQG---NEARVYEFIVRHFLACLSKNAEGRETTVEIDIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+  G  I+ KNYLDVY ++ W    I +Y   Q F PT++ +    T  P LL+EA
Sbjct: 429 GEKFTTNGLEIIAKNYLDVYIYDKWNNKQIHSYEQRQVFRPTSIDMVEEKTSAPNLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L++ MDK GIGTDAT  DHI  +  R Y     S  F P  LG  LVMGYD+  M +++
Sbjct: 489 ELIALMDKHGIGTDATHADHIDTIKSRQYVGLTDSQHFMPGKLGIGLVMGYDN--MGFQM 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-QRS 310
            KP LR+++E+D+K + E  K  + VL   +D  +  F  A      + +A++ +  +R 
Sbjct: 547 SKPHLRASLENDLKLICERRKDPNEVLQNQIDTYREVFKVAMERANLIDDALAQYLDERP 606

Query: 311 NRSAGDELHATGEV-VRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPGSVSE 368
            +S   +     +V + +C  C  S+MVLK+ + G    + C+G+P C N +W P +V +
Sbjct: 607 TQSEQIQFPLVTDVAIFKCPKCG-SNMVLKERKQGKGKYISCMGYPTCLNVIWFPEAVKD 665

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
             +    CN CT G +++++    +  + P Y  ++  CI GCD    ++  I
Sbjct: 666 VEILNEICNQCT-GNIHKLKFTLVR-NVLPLYGTSYTTCI-GCDNAFNEILNI 715


>D6WYH2_TRICA (tr|D6WYH2) DNA topoisomerase OS=Tribolium castaneum
           GN=TcasGA2_TC006688 PE=3 SV=1
          Length = 951

 Score =  292 bits (747), Expect = 2e-76,   Method: Compositional matrix adjust.
 Identities = 171/405 (42%), Positives = 227/405 (56%), Gaps = 14/405 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G ISYPRTET+ F    NL  +V  QQ    WG +A R+++ E G    P
Sbjct: 315 MKIAEKLYTQGLISYPRTETNIFPKELNLANLVTLQQNDQRWGAFAHRIMN-EGGPA--P 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N +++YE +VRHFLACV K A G ET V  DIA
Sbjct: 372 RQGKKSDQAHPPIHPTKHADNLTG---NEQRVYEYIVRHFLACVHKDAQGFETVVTADIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+A G +ILEKNYL+VY +E W    I +Y  G  F P+ L L  G T PP LL+EA
Sbjct: 429 GEKFTAKGLIILEKNYLEVYTYEKWNAKEIHSYQQGDTFIPSVLELYEGATAPPKLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI  +  R Y     +  F P  LG  LV GY++I +   L
Sbjct: 489 DLIALMEKHGIGTDATHAEHIDTIKTREYVGLHENIYFVPGTLGMGLVEGYNNIGLEVSL 548

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+  E D+K + +G K  + V    + K +A F        ++ E ++       
Sbjct: 549 AKPILRADFEKDLKLICDGLKDPEVVRREQIQKYRAVFETVVEKMRQIDECLANRLADRP 608

Query: 312 RSAGDELHATGEV--VRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQCRNAVWLPGSVS 367
           +   DE +   EV  V +C  C  +DM +  KKN  G F + C G+P CRNA+WL  +V 
Sbjct: 609 QVVEDEHYENVEVRPVLKCPKCG-NDMTIRNKKNNAGKF-ISCTGYPDCRNAIWLSQNVE 666

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCD 412
              V    C  C P  V  +++KF+Q       N N L CIGGCD
Sbjct: 667 TIEVLDESCPQCGPN-VKLVKMKFKQNVFVGEPNPNTL-CIGGCD 709


>B4KIW5_DROMO (tr|B4KIW5) DNA topoisomerase OS=Drosophila mojavensis
           GN=Dmoj\GI18230 PE=3 SV=1
          Length = 1279

 Score =  291 bits (746), Expect = 3e-76,   Method: Compositional matrix adjust.
 Identities = 168/387 (43%), Positives = 224/387 (57%), Gaps = 22/387 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR-N 70
           + +AE+LY  GFISYPRTET+ FS    L  +V++Q GH  WG +AQR+L+     W  N
Sbjct: 317 MTIAEKLYSKGFISYPRTETNQFSKEFELTPLVEQQTGHEAWGAFAQRVLE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK  +   G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPTKLVSNLQG---NEARVYELVVRHFLACVSKDAVGSETIVSIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE FSA G VI E+NYLDVY ++ W    I  Y  GQ+F PT + L  G T  PPLL+E
Sbjct: 429 AGEKFSASGLVIHERNYLDVYVYDKWSAKQIHNYQQGQRFEPTEIMLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+   
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVVEKGALVPGVIGMGLYEGYDAMELT-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+  E+D+K +  G K    VL   + K K  +    ++K+  ++      QR 
Sbjct: 547 LAKPLLRAEFEADLKRICLGEKDPKLVLREQIAKYKTAYQQI-MDKITAMD--DKIAQRI 603

Query: 311 NR--SAGDELHATGEV--VRRCGLCQESDMVLK-KNRDGNFMVGCLGFPQCRNAVWLPGS 365
           N   +A     ++G V  +  C  C+++ + LK K    +F +GCL FP C+N +WLP  
Sbjct: 604 NETPTAATANPSSGLVHELFPCPKCEQAPLALKPKKNQTSFFIGCLNFPDCKNVIWLPEE 663

Query: 366 VSEAAVTTNPCNFCTPGPVYRIQLKFR 392
             E  V    C  C  G  Y++ LKF+
Sbjct: 664 CKELTVLDECCPTCGDG--YKM-LKFK 687


>B4Q9Z3_DROSI (tr|B4Q9Z3) DNA topoisomerase OS=Drosophila simulans
           GN=Dsim\GD24215 PE=3 SV=1
          Length = 857

 Score =  291 bits (746), Expect = 3e-76,   Method: Compositional matrix adjust.
 Identities = 180/432 (41%), Positives = 240/432 (55%), Gaps = 36/432 (8%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLW-RN 70
           + +AE+LY  GFISYPRTET+ FS    L  +V+ Q GH +WG +AQR+++     W  N
Sbjct: 317 MTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK +    G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPTKLAENLQG---NEARVYELVVRHFLACVSKDAVGSETLVHIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE F+A G VI E+NYLDVY ++ W    I  Y  GQ+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP+LR+  E D+K + +G K    VL   + K K  +     +K+  ++A      R 
Sbjct: 547 LAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQSYQQI-TDKITAMDAK--ISARI 603

Query: 311 NRSAGDELHATG------------EVVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQC 356
           N +        G            + + +C  C E+ + L  KKN+ G + +GC  FP C
Sbjct: 604 NETPPANSAGQGGADGSGPSQGIIQSIFQCPKCNEAPLALKPKKNQQG-WYIGCNNFPDC 662

Query: 357 RNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILR 416
           +NAVWLP    +A+V    C  C  G  YR+ LKFR L  P  Y         GC +  R
Sbjct: 663 KNAVWLPTECKDASVLDECCPTCGDG--YRM-LKFR-LSTP--YYRGVFSTPSGCQQPAR 716

Query: 417 QLTEICGTGPRM 428
           Q T +   GP +
Sbjct: 717 QNT-VRRNGPNL 727


>L1K3I3_GUITH (tr|L1K3I3) Uncharacterized protein OS=Guillardia theta CCMP2712
           GN=GUITHDRAFT_156833 PE=3 SV=1
          Length = 652

 Score =  291 bits (744), Expect = 4e-76,   Method: Compositional matrix adjust.
 Identities = 156/333 (46%), Positives = 207/333 (62%), Gaps = 11/333 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AEELY  GFISYPRTET+ F   TNL  ++ +Q     WG YA  LL   AG ++ P
Sbjct: 319 MQIAEELYNKGFISYPRTETEKFKEGTNLQELISKQCESGHWGNYANELL---AGSFQWP 375

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G +DD+AHPPIHPT+F+   SG      +LYELVVRHFLAC SK A+GAETTVEI I 
Sbjct: 376 RAGQNDDQAHPPIHPTQFTNSLSG---KQAQLYELVVRHFLACCSKNAIGAETTVEISIG 432

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F + G +I E N+L VYP+E W    IP +T G+QF PT L +  G T+ PPLLSEA
Sbjct: 433 VEQFVSKGLMIKELNWLKVYPYERWSDKDIPIFTEGEQFEPTELAMTEGRTQAPPLLSEA 492

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MD  GIGTDAT+ +HI K+  R YA K  S +F+PT+LG++LV  Y+ I    +L
Sbjct: 493 DLISLMDSHGIGTDATIAEHITKVQQRDYAIKSDSQQFSPTSLGKSLVTSYEAI--GLEL 550

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +P  R+ ME DM  ++ G      V+   ++ MK  F      + ++ + MS+FFQ  N
Sbjct: 551 ARPHFRARMEQDMTKIASGQTSARVVIEEWMEIMKPIFQRCIAGQTQMAQEMSVFFQPLN 610

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDG 344
            S+  +       V +CG+C    M LKK R+G
Sbjct: 611 ASSWSQTLQRN--VSQCGVC-SGLMDLKKQRNG 640


>B4JCW0_DROGR (tr|B4JCW0) DNA topoisomerase OS=Drosophila grimshawi
           GN=Dgri\GH11108 PE=3 SV=1
          Length = 1269

 Score =  291 bits (744), Expect = 5e-76,   Method: Compositional matrix adjust.
 Identities = 175/392 (44%), Positives = 221/392 (56%), Gaps = 27/392 (6%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR-N 70
           + +AE+LY  G ISYPRTET+ FS    L  IV +Q  H  WG +AQR+L+     W  N
Sbjct: 317 MTIAEKLYSQGIISYPRTETNQFSKEFELAPIVAQQTSHEAWGAFAQRVLE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHP K   G  G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGTKSDQAHPPIHPIKLVTGLQG---NEARVYELVVRHFLACVSKDAVGSETIVNIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE FSA G VI E+NYLDVY +E W    I  Y  GQ+F PT + L  G T  PPLL+E
Sbjct: 429 AGEKFSANGLVIHERNYLDVYVYENWSAKQIHNYERGQRFEPTEIMLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  +  R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTVKKRGYIGVVDKGALVPGIIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+  E+D+K +  G K    VL+  + K K  +    ++K+  ++A     QR 
Sbjct: 547 LAKPLLRAEFEADLKRICLGEKDPRLVLSEQIVKYKQAYQQI-MDKITAMDAK--ISQRL 603

Query: 311 NR-----SAGDELHA-TGEVVRR---CGLCQESDMVLK-KNRDGNFMVGCLGFPQCRNAV 360
           N      SA D     T  +VR    C  C ++ + LK K    +F +GCL FP C+N V
Sbjct: 604 NETPAVPSATDNPSGQTSGMVRELFPCPQCDQAQLALKPKKNQTSFFIGCLNFPDCKNVV 663

Query: 361 WLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           WLP    E +V    C  C  G  Y + LKFR
Sbjct: 664 WLPEECKEYSVLDECCPNCGDG--YHM-LKFR 692


>B4I5W5_DROSE (tr|B4I5W5) DNA topoisomerase OS=Drosophila sechellia
           GN=Dsec\GM17356 PE=3 SV=1
          Length = 1251

 Score =  290 bits (742), Expect = 8e-76,   Method: Compositional matrix adjust.
 Identities = 170/396 (42%), Positives = 227/396 (57%), Gaps = 32/396 (8%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLW-RN 70
           + +AE+LY  GFISYPRTET+ FS    L  +V+ Q GH +WG +AQR+++     W  N
Sbjct: 317 MTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK +    G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPTKLAENLQG---NEARVYELVVRHFLACVSKDAVGSETLVHIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE F+A G VI E+NYLDVY ++ W    I  Y  GQ+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVLEKGFLVPGVIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP+LR+  E D+K + +G K    VL   + K K  +     +K+  ++A      R 
Sbjct: 547 LAKPQLRAEFELDLKLICQGQKDPKVVLTEQIVKYKQSYQQI-TDKITAMDAK--ISARI 603

Query: 311 NRSAGDELHATG------------EVVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQC 356
           N +        G            + + +C  C E+ + L  KKN+ G + +GC  FP C
Sbjct: 604 NETPAANSAGQGGADGSGPSLGIIQSIFQCPKCNEAPLALKPKKNQQG-WYIGCNNFPDC 662

Query: 357 RNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           +NAVWLP    +A+V    C  C  G  YR+ LKFR
Sbjct: 663 KNAVWLPTECKDASVLDECCPTCGDG--YRM-LKFR 695


>K4BYJ2_SOLLC (tr|K4BYJ2) Uncharacterized protein OS=Solanum lycopersicum
           GN=Solyc05g014730.1 PE=3 SV=1
          Length = 212

 Score =  290 bits (741), Expect = 1e-75,   Method: Compositional matrix adjust.
 Identities = 142/187 (75%), Positives = 155/187 (82%), Gaps = 2/187 (1%)

Query: 169 QFTPTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR 228
           QFTPT LTLDSGV RPPPLLSEADLL CMDK GIGTDATMHDHIKKLLDRFYA KD++TR
Sbjct: 4   QFTPTTLTLDSGVIRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYAIKDSNTR 63

Query: 229 FTPTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKAC 288
           F+PT LGEALVMGYDD  M Y+LWKP LR+ ME DMK+VS GTK K  VL T L +MKAC
Sbjct: 64  FSPTKLGEALVMGYDD--MGYELWKPYLRAMMECDMKAVSTGTKRKAEVLETCLQQMKAC 121

Query: 289 FLHARLNKVKLLEAMSIFFQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMV 348
           F  AR NK KLLEAM+IFF+RSNRS+  E  A G VVRRCGLC ESDMVL++  DGNFMV
Sbjct: 122 FSDARTNKEKLLEAMAIFFERSNRSSSGEQQAVGAVVRRCGLCLESDMVLRQKPDGNFMV 181

Query: 349 GCLGFPQ 355
           GCLG+PQ
Sbjct: 182 GCLGYPQ 188


>E2BS26_HARSA (tr|E2BS26) DNA topoisomerase OS=Harpegnathos saltator GN=EAI_11470
           PE=3 SV=1
          Length = 1049

 Score =  289 bits (740), Expect = 1e-75,   Method: Compositional matrix adjust.
 Identities = 168/426 (39%), Positives = 241/426 (56%), Gaps = 24/426 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  G ISYPRTET+ F    NL A+V++Q  +  WG +A+ LL  E+G+   P
Sbjct: 316 MRIAERLYTQGLISYPRTETNIFPKELNLAALVEQQVNNQAWGNFARGLL--ESGII--P 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N  K+YE VVRHFLACVSK A G ETTVEIDIA
Sbjct: 372 RQGKKSDQAHPPIHPTKYTDNLQG---NEAKVYEFVVRHFLACVSKNAEGQETTVEIDIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F+  G  +L KNYLDVY +E W    I +Y   Q F PT++ +    T PP LL+EA
Sbjct: 429 GEKFTTNGLEVLAKNYLDVYIYEKWNDKEIHSYQPRQVFRPTSIDMVEEKTSPPNLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L++ MDK GIGTDAT  +HI  +  R Y     +  F P  LG  LVMGYD+  M +++
Sbjct: 489 ELIALMDKHGIGTDATHAEHIDTIKSRQYVGLTDTQHFMPGKLGIGLVMGYDN--MGFQM 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLL-EAMSIFFQRS 310
            KP LR+ +E D++ + +  K  + VL + ++K +  F  A + +  L+ +A++ +    
Sbjct: 547 SKPNLRADLEKDLQLICQRQKDPNEVLQSQINKYREVFKIA-IERANLIDDALARYLDER 605

Query: 311 NRSAGDELHATGEVVR-----RCGLCQESDMVLKKNRDGN-FMVGCLGFPQCRNAVWLPG 364
               G+ L    E V      RCG    S+M+LK  + G    + C G+P C N +WL  
Sbjct: 606 PIENGETLSRFVEDVSIFKCPRCG----SNMILKNRKQGRGKYISCAGYPACTNVIWLSE 661

Query: 365 SVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGT 424
           ++ +  V +  CN CT   + +++ K  +  + P Y  ++  CI GCD    ++  I   
Sbjct: 662 AIEDVEVLSETCNQCTEN-IRKLKFKLVR-NVVPLYGTSYTTCI-GCDSTFNEMLNIKND 718

Query: 425 GPRMPG 430
             R  G
Sbjct: 719 CIRQTG 724


>B4M8K0_DROVI (tr|B4M8K0) DNA topoisomerase OS=Drosophila virilis GN=Dvir\GJ18138
           PE=3 SV=1
          Length = 1355

 Score =  288 bits (738), Expect = 3e-75,   Method: Compositional matrix adjust.
 Identities = 170/396 (42%), Positives = 219/396 (55%), Gaps = 35/396 (8%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR-N 70
           + +AE+LY  GFISYPRTET+ FS    L  +V++  GH  WG +AQR+L+     W  N
Sbjct: 317 MTIAEKLYSKGFISYPRTETNQFSKEFELAPLVEQHTGHEAWGAFAQRVLE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK      G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPTKMVTNLQG---NEARVYELVVRHFLACVSKDAVGSETIVSIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE FSA G VI E+NYLDVY ++ W    I  Y  GQ+F PT + L  G T  PPLL+E
Sbjct: 429 AGEKFSANGLVIHERNYLDVYVYDKWSAKQIHNYEQGQRFEPTEIVLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVVDKGALVPGVIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF-------------LHARLNKV 297
           L KP LR+  E+D+K +  G K    VL   + K K  +             +  R+N+ 
Sbjct: 547 LAKPLLRAEFEADLKRICLGEKDPKLVLREQIAKYKQAYQQIMEKITAMDAKIAQRINET 606

Query: 298 KLLEAMSIFFQRSNRSAGDELHATGEVVRRCGLCQESDMVLK-KNRDGNFMVGCLGFPQC 356
               A S   Q  + +   EL        +C  C+ + +VLK K    +F +GCL FP C
Sbjct: 607 PAAAATSDASQEQSINIPRELF-------QCPKCELAPLVLKPKKVQTSFFIGCLNFPDC 659

Query: 357 RNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           +N +WLP    E  V    C  C  G  Y + LKFR
Sbjct: 660 KNVIWLPEDCKEYCVLDECCPSCGEG--YHM-LKFR 692


>B4GWY2_DROPE (tr|B4GWY2) DNA topoisomerase OS=Drosophila persimilis
           GN=Dper\GL21219 PE=3 SV=1
          Length = 1178

 Score =  288 bits (736), Expect = 4e-75,   Method: Compositional matrix adjust.
 Identities = 170/391 (43%), Positives = 226/391 (57%), Gaps = 25/391 (6%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLW-RN 70
           + +AE+LY  GFISYPRTET+ FS    L  +VQ Q GH +WG +AQR+LD     W  N
Sbjct: 317 MTIAEKLYSKGFISYPRTETNQFSKEFELAPLVQLQAGHSDWGAFAQRVLD-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK +    G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGSKSDQAHPPIHPTKSADNLQG---NEARVYELVVRHFLACVSKDAVGSETVVNIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE F+A G VI E+NYLDVY ++ W    I  Y   Q+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFTANGLVIHERNYLDVYVYDKWSAKRIHHYERDQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGALVPGVIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEA-MSIFFQR 309
           L KP+LR+  E+D+K +  G K    VL   + K K  +     +K+  ++A +S     
Sbjct: 547 LAKPQLRAEFEADLKLICLGQKDPQLVLTEQIAKYKLSYQQI-TDKITAMDAKISARINE 605

Query: 310 S------NRSAGDELHATGEVVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQCRNAVW 361
           +       + A      T + + +C  C E+ + L  KKN+ G + +GC  FP C+N VW
Sbjct: 606 APAATPPGQPAVGHNQLTMQTLFQCPKCDEAPLALKPKKNQQG-WYIGCNNFPDCKNVVW 664

Query: 362 LPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           LP    E +V    C  C  G  +R+ LKFR
Sbjct: 665 LPEECKEVSVLDECCPTCGAG--HRM-LKFR 692


>Q29K61_DROPS (tr|Q29K61) DNA topoisomerase OS=Drosophila pseudoobscura
           pseudoobscura GN=Dpse\GA10090 PE=3 SV=2
          Length = 1178

 Score =  286 bits (732), Expect = 1e-74,   Method: Compositional matrix adjust.
 Identities = 169/391 (43%), Positives = 226/391 (57%), Gaps = 25/391 (6%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLW-RN 70
           + +AE+LY  GFISYPRTET+ FS    L  +VQ Q GH +WG +A+R+LD     W  N
Sbjct: 317 MTIAEKLYSKGFISYPRTETNQFSKEFELAPLVQLQAGHSDWGAFARRVLD-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK +    G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGSKSDQAHPPIHPTKSADNLQG---NEARVYELVVRHFLACVSKDAVGSETVVNIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE F+A G VI E+NYLDVY ++ W    I  Y   Q+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFTANGLVIHERNYLDVYVYDKWSAKRIHHYERDQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGALVPGVIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEA-MSIFFQR 309
           L KP+LR+  E+D+K +  G K    VL   + K K  +     +K+  ++A +S     
Sbjct: 547 LAKPQLRAEFEADLKLICLGQKDPQLVLTEQIAKYKLSYQQI-TDKITAMDAKISARINE 605

Query: 310 S------NRSAGDELHATGEVVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQCRNAVW 361
           +       + A      T + + +C  C E+ + L  KKN+ G + +GC  FP C+N VW
Sbjct: 606 APAATPPGQPAVGHNQLTMQTLFQCPKCDEAPLALKPKKNQQG-WYIGCNNFPDCKNVVW 664

Query: 362 LPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           LP    E +V    C  C  G  +R+ LKFR
Sbjct: 665 LPEECKEVSVLDECCPTCGAG--HRM-LKFR 692


>F4PXY0_DICFS (tr|F4PXY0) DNA topoisomerase III OS=Dictyostelium fasciculatum
           (strain SH3) GN=top3 PE=3 SV=1
          Length = 812

 Score =  285 bits (730), Expect = 2e-74,   Method: Compositional matrix adjust.
 Identities = 157/370 (42%), Positives = 219/370 (59%), Gaps = 16/370 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AEELY  GFISYPRTET  F   T+   ++  Q G P+WG YA RLL+   G ++ P
Sbjct: 336 MKIAEELYNKGFISYPRTETSQFIDGTDFQGLIGLQTGDPQWGQYATRLLN---GEFKRP 392

Query: 72  RGGGHDDKAHPPIHPTKF-SAGESGWSQ-NHRKLYELVVRHFLACVSKPAVGAETTVEID 129
             G  +D +HPPIHPT F   G +G      R+LYE +VRHFLAC S  ++ A+TTV ID
Sbjct: 393 NDGRTNDHSHPPIHPTNFLPPGAAGAKDPKARELYEFIVRHFLACCSPESIIAKTTVSID 452

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           +AGE FS  G +I+ + YL+VY +E     +IPTY VG+QFTPT + L+SG T  P  LS
Sbjct: 453 VAGEKFSESGSMIIRRGYLEVYKYEKRNDKIIPTYEVGEQFTPTDIKLESGRTVSPRPLS 512

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           E +LLS MD   IGTDATM  HI+K+++R Y  KDA   F PTNLG+AL++GYD   M +
Sbjct: 513 EPELLSAMDSNQIGTDATMAQHIQKIIERGYVIKDADQLFVPTNLGKALIVGYDS--MGF 570

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
           +  KP LR+++E+D++ +  G + K+ VL  +++K K  F+ A+ N+ ++L+   + F +
Sbjct: 571 EFSKPALRASIEADIQKIGLGQRTKEQVLRDTIEKYKTLFIQAQ-NQTQMLD---VAFSK 626

Query: 310 SNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
              S G           +CG C    M LKK      ++ C     C  +  LP    E 
Sbjct: 627 HFASKGQTYQTLKANFSKCGKCNNL-MDLKKTNGDRKILNC---STCNTSYNLPQK-GEF 681

Query: 370 AVTTNPCNFC 379
            V  + C  C
Sbjct: 682 IVNAHTCPLC 691


>B4MYR0_DROWI (tr|B4MYR0) DNA topoisomerase OS=Drosophila willistoni
           GN=Dwil\GK18189 PE=3 SV=1
          Length = 1234

 Score =  285 bits (729), Expect = 2e-74,   Method: Compositional matrix adjust.
 Identities = 179/432 (41%), Positives = 236/432 (54%), Gaps = 41/432 (9%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLW-RN 70
           + +AE+LY  GFISYPRTET+ F+   NL  +V+  + H +WG +AQR+LD     W  N
Sbjct: 317 MTIAEKLYSKGFISYPRTETNQFTKEFNLVPLVELHKDHNDWGAFAQRVLD-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHP K +    G   N  ++YE+VVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPIKAAINLQG---NEARVYEMVVRHFLACVSKDAVGSETIVNIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE FSA G VI E+NYLDVY +E W    I  Y   Q+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFSANGLVIHERNYLDVYVYEKWNAKQIHHYERDQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ MDK GIGTDAT  +HI  + +R Y          P  +G  L  GYD +E+A  
Sbjct: 489 ADLIALMDKHGIGTDATHAEHISTIKERGYIGVIDKGFLVPGVIGMGLYEGYDAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+  ESD+K +  G K    VL+  + K K  +     +K+  ++       R 
Sbjct: 547 LAKPLLRAEFESDLKLICLGQKDPKVVLSEQIAKYKVAYQQI-TDKITAMD--DKIAHRI 603

Query: 311 NRS-------------AGDELHATGEVVRRCGLCQESDMVLK--KNRDGNFMVGCLGFPQ 355
           N +               + +    + + +C  C E+ + LK  KN+ G F +GCL FP 
Sbjct: 604 NETPAANNAAAGNGNDGQENVSNMQQELSQCPKCDEAPLALKARKNQQGWF-IGCLNFPD 662

Query: 356 CRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPN---YNINH---LGCIG 409
           C+N VWLP    E  V    C  C  G  +R+ LKFR L  P     +N  H     C+ 
Sbjct: 663 CKNVVWLPSECKEITVLDECCPTCGDG--HRM-LKFR-LSTPYYRGLFNTPHGWYKTCL- 717

Query: 410 GCDEILRQLTEI 421
            CDE+ R    I
Sbjct: 718 PCDELFRNTFNI 729


>B3MN55_DROAN (tr|B3MN55) DNA topoisomerase OS=Drosophila ananassae
           GN=Dana\GF14242 PE=3 SV=1
          Length = 1209

 Score =  285 bits (729), Expect = 2e-74,   Method: Compositional matrix adjust.
 Identities = 167/393 (42%), Positives = 226/393 (57%), Gaps = 26/393 (6%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR-N 70
           + +AE+LY  GFISYPRTET+ FS    L  +V+ Q G+  WG +AQR+++     W  N
Sbjct: 317 MTIAEKLYSKGFISYPRTETNQFSKEFELLPLVEMQTGNAAWGPFAQRVVE-----WGPN 371

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G   D+AHPPIHPTK +    G   N  ++YELVVRHFLACVSK AVG+ET V IDI
Sbjct: 372 PRNGNKSDQAHPPIHPTKAADNLQG---NEARVYELVVRHFLACVSKDAVGSETLVNIDI 428

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           AGE F+A G VI E+NYLDVY ++ W    I  Y   Q+F PT ++L  G T  PPLL+E
Sbjct: 429 AGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYERNQRFEPTEVSLHEGATTAPPLLTE 488

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
           ADL++ M+K GIGTDAT  +HI  + +R Y          P  +G  L  GY  +E+A  
Sbjct: 489 ADLIALMEKHGIGTDATHAEHINTIKERGYIGMVDKGALVPGVIGMGLYEGYGAMELA-- 546

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF--LHARLNKVKLLEAMSIFFQ 308
           L KP+LR+  E D+K + +G K   AVLA  + K K  +  +  ++  +    A  I   
Sbjct: 547 LAKPQLRAEFELDLKLICQGQKDPKAVLADQITKYKQSYQQITDKITAMDAKIAARINEM 606

Query: 309 RSNRSAGDELHATGE-------VVRRCGLCQESDMVL--KKNRDGNFMVGCLGFPQCRNA 359
            +  ++G E     E        + +C  C  + + L  KKN+ G + +GC  FP C+NA
Sbjct: 607 PAENTSGQEGAQGSEQNQPAMQTLFQCPKCNVAPLALKAKKNQQG-WYIGCTNFPDCKNA 665

Query: 360 VWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFR 392
           VWLP    +  VT   C+ C  G  +R+ LKFR
Sbjct: 666 VWLPSECKDVTVTNESCSRC--GDSHRL-LKFR 695


>F7CBA4_CALJA (tr|F7CBA4) DNA topoisomerase OS=Callithrix jacchus PE=3 SV=1
          Length = 990

 Score =  278 bits (712), Expect = 2e-72,   Method: Compositional matrix adjust.
 Identities = 158/413 (38%), Positives = 231/413 (55%), Gaps = 24/413 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ETTVEIDI+
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---NEQRLYEFIVRHFLACCSQDAQGQETTVEIDIS 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGFRFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMG-YDDIEMAYK 250
           DL++ M+K GI   A    H K       + K +  +  P   G    MG          
Sbjct: 522 DLIALMEKHGI---AAPKPHSKT----SESVKGSPVQGRPEE-GHGSRMGLVSHTNSLGH 573

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           + +  L+ + ++ + S  E    ++      L  +  C L       +L EA++ +F   
Sbjct: 574 MGRKILKRSFQAGIDSFHEKWDVREQESNCRLMGVYLCLL------FRLDEALAQYFGNG 627

Query: 311 NRSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
              A  E    A  E +R+C  C + DMVLK  ++G   + C GFP+CR+A+W P SV E
Sbjct: 628 TEVAQQEDIYPAMPEPIRKCPQCNK-DMVLKTKKNGGLYLSCTGFPECRSAIWFPDSVLE 686

Query: 369 AAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           A+   + C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 687 ASRDGSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 739


>D7FUP7_ECTSI (tr|D7FUP7) DNA topoisomerase OS=Ectocarpus siliculosus
           GN=Esi_0276_0016 PE=3 SV=1
          Length = 759

 Score =  278 bits (711), Expect = 3e-72,   Method: Compositional matrix adjust.
 Identities = 156/351 (44%), Positives = 215/351 (61%), Gaps = 12/351 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + + VAE LYQ G ISYPRTET+ F    +++ ++ + + +P +G Y   LLD    LW 
Sbjct: 127 RTMHVAEALYQRGIISYPRTETEKFKREFDINTLLGDFRDNPRFGNYVGGLLDNGGFLW- 185

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  DD AHPPIHPTK S   +    + +K+YELV +HFLAC SK AVG +T V  +
Sbjct: 186 -PREGRGDDSAHPPIHPTK-SVDPNSLQADEKKIYELVTKHFLACCSKDAVGHQTKVLAN 243

Query: 130 IAGELFSACGRVILEKNYLDVY-PFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLL 188
             GE F+A G ++ E+N+LDVY PFE W G  IP +  GQ+F P+ L +D G T+ PPLL
Sbjct: 244 CGGEDFTATGLMVTERNWLDVYEPFERWTGRNIPEFFQGQEFVPSVLVMDEGRTQAPPLL 303

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMA 248
           SE+DL+  MD++GIGTDAT+ +HI+K+  R YA K+   RF PT LG ALV GYD+I   
Sbjct: 304 SESDLIGLMDQKGIGTDATIAEHIQKIQQRKYAVKNEQDRFYPTTLGLALVDGYDNI--G 361

Query: 249 YKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQ 308
           +++  P LR+AME D   +S G   K+AV+   + KMK CF   +    KL +A+++ F+
Sbjct: 362 FQMSAPTLRAAMELDCTRISRGEDTKEAVVERCISKMKECFQTCQALAHKLDDAVAMHFR 421

Query: 309 RSNRSAGDELHAT-GEVVRRCGLCQESDMVLKKNRDGNFMVGC----LGFP 354
               S G+      G    RCG+C  + M LKK+  G  ++ C     GFP
Sbjct: 422 PLGSSGGESRTVRGGRGFSRCGVCGTA-MDLKKSSSGRPLLFCGVCDTGFP 471


>E9IAV6_SOLIN (tr|E9IAV6) DNA topoisomerase (Fragment) OS=Solenopsis invicta
           GN=SINV_07705 PE=3 SV=1
          Length = 1052

 Score =  278 bits (711), Expect = 3e-72,   Method: Compositional matrix adjust.
 Identities = 161/416 (38%), Positives = 234/416 (56%), Gaps = 21/416 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTETD F    NL ++VQ+Q  + +WG +A+ LL  E+G+   P
Sbjct: 316 MRIAERLYTQGFISYPRTETDIFPKEMNLTSLVQQQVPNRDWGDFARNLL--ESGV--TP 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N  K+YE VVRHFLAC+SK A G ETTV+I+IA
Sbjct: 372 RQGKKSDQAHPPIHPTKYTDSLQG---NEAKVYEFVVRHFLACLSKNAEGRETTVDINIA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+A G  I+ KNYL+VY +E W    I +Y   Q F PT++ +    T PP LL+EA
Sbjct: 429 NERFTANGLEIIAKNYLEVYIYEKWNNKQIHSYQQRQVFRPTSIEMIEEKTSPPKLLTEA 488

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L++ MDK GIGTDAT  +HI  +  R Y     +  F P  LG  LVMGYD+  M +++
Sbjct: 489 ELIALMDKHGIGTDATHAEHIDTIKSRQYVGLTNTQHFMPGKLGIGLVMGYDN--MGFQM 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLL-EAMSIFFQR- 309
            KP LR+ +E D++ + +  K  + VL   ++K +  F  A + +  L+ E+++ +    
Sbjct: 547 SKPHLRADLEKDLQLICQRQKNPNEVLQNQINKYREVFEVA-IERANLIDESLAQYLDER 605

Query: 310 --SNRSAGDELHATGEVVRRCGLCQESDMVLKKNRD-GNFMVGCLGFPQCRNAVWLPGSV 366
                     L      + +C  C  S+M L+  R  G   + C+G+P C+N VW P ++
Sbjct: 606 PLQTEQIAPLLPPQQVAIFKCPKCG-SNMTLQNRRQGGGKFISCMGYPTCKNVVWFPEAI 664

Query: 367 SEAAVTTNPCNFCTPGPVYRIQLKFRQL-EIPPNYNINHLGCIGGCDEILRQLTEI 421
            +  V    C  CT       +LKF  +  + P Y  ++  CI  CD    ++  I
Sbjct: 665 KDIEVLNETCTQCTEN---MRKLKFTLVRNVIPLYGTSYTTCI-SCDTQFNEMLNI 716


>F7BHS6_CALJA (tr|F7BHS6) DNA topoisomerase OS=Callithrix jacchus PE=3 SV=1
          Length = 996

 Score =  277 bits (708), Expect = 8e-72,   Method: Compositional matrix adjust.
 Identities = 158/414 (38%), Positives = 232/414 (56%), Gaps = 20/414 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE+LY  G+ISYPRTET+ F    NL  +V++Q   P WG +AQ +L+        P
Sbjct: 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP---TP 404

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK++    G   N ++LYE +VRHFLAC S+ A G ETTVEIDI+
Sbjct: 405 RNGNKSDQAHPPIHPTKYTNSLQG---NEQRLYEFIVRHFLACCSQDAQGQETTVEIDIS 461

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G +IL +NYLDVYP++ W   ++P Y  G +F P+ + +  G T PP LL+EA
Sbjct: 462 QERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGFRFQPSTVEMVDGETSPPKLLTEA 521

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIG  +     ++ LL   +       +F   N G   +  +   E+   L
Sbjct: 522 DLIALMEKHGIGQSSGYLISLEHLLCTRHRFPLVFKQF--CNAGTISLSPFYSSEVK-NL 578

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKA--CFLHARLNKVKLLEAMSIFFQR 309
            K      +   + ++ E        L ++   M    C L       +L EA++ +F  
Sbjct: 579 PKVSRARWLTPVIPALWEAEAECCRCLCSNCRLMGVYLCLL------FRLDEALAQYFGN 632

Query: 310 SNRSAGDE--LHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVS 367
               A  E    A  E +R+C  C + DMVLK  ++G   + C GFP+CR+A+W P SV 
Sbjct: 633 GTEVAQQEDIYPAMPEPIRKCPQCNK-DMVLKTKKNGGLYLSCTGFPECRSAIWFPDSVL 691

Query: 368 EAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           EA+   + C  C P PVYR++LKF++  +PP   +  + CIGGCDE LR++ ++
Sbjct: 692 EASRDGSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDETLREILDL 745


>E3WTA7_ANODA (tr|E3WTA7) DNA topoisomerase OS=Anopheles darlingi GN=AND_06414 PE=3
            SV=1
          Length = 1456

 Score =  276 bits (707), Expect = 9e-72,   Method: Compositional matrix adjust.
 Identities = 169/429 (39%), Positives = 236/429 (55%), Gaps = 36/429 (8%)

Query: 12   LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
            + +AE+LY  G ISYPRTET+ F+   NL  +VQ Q  + +WG +A+++L  E G+  NP
Sbjct: 771  MTIAEKLYTQGIISYPRTETNMFTSDMNLVPLVQAQVANQQWGSFAEKVL--EWGV--NP 826

Query: 72   RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
            R G   D+AHPPIHPTK     SG   +  ++YEL+ RHFLACVS+ A G+ET V + +A
Sbjct: 827  RNGKKSDQAHPPIHPTKLPTNLSG---DEWRVYELIARHFLACVSRDATGSETIVNVVVA 883

Query: 132  GEL-FSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
             E  F+A G  I E+NYL+VYP++ W    I  Y VG  F PT L L  G T  P +L+E
Sbjct: 884  DEEEFTASGLCIYERNYLEVYPYDRWNAKEIHVYRVGHTFEPTELGLHEGSTTAPNMLTE 943

Query: 191  ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYK 250
            ADL++ M+K GIGTDAT  +HI  + +R Y  +       P  LG  LV GY+ +E+  +
Sbjct: 944  ADLIALMEKHGIGTDATHAEHINTIKERGYIGERDRGFLVPGTLGMGLVEGYEMMEL--R 1001

Query: 251  LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
            L  PELR+ +E+D+K + EG K   AVLA  + K K  +   R+   K         QR 
Sbjct: 1002 LAHPELRAGLEADLKLICEGRKDPAAVLAEQVSKYKEVY---RIMSRKAQALDRALGQRL 1058

Query: 311  NRSAGD-------------ELHATGEVVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQC 356
            N++  D                A+ + V +C  C E  M L++ RDGN + +GC+ FP C
Sbjct: 1059 NQTPRDPPPDGGGGGGAIAIGGASLKEVCKCPKCGEK-MCLRQKRDGNGYHLGCVAFPNC 1117

Query: 357  RNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLE----IPPNYNINHLGCIGGCD 412
            +N+VW   S+ EA VT + C  C      +I +KFR +     +       +  CI  CD
Sbjct: 1118 KNSVWFDDSIREATVTDDACARCGSK---KITVKFRNMHYYGLLQSTSMTEYRTCI-VCD 1173

Query: 413  EILRQLTEI 421
               R L  I
Sbjct: 1174 SKFRGLLNI 1182


>D3BRX9_POLPA (tr|D3BRX9) Ribose-phosphate pyrophosphokinase OS=Polysphondylium
           pallidum GN=top3 PE=3 SV=1
          Length = 1103

 Score =  274 bits (701), Expect = 4e-71,   Method: Compositional matrix adjust.
 Identities = 151/369 (40%), Positives = 214/369 (57%), Gaps = 18/369 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AEELY  GFISYPRTETDSF P T+   +++ Q  + +WG YAQ LL+   G +  P
Sbjct: 647 MKLAEELYNKGFISYPRTETDSFLPETDFMGLIRLQTDNQKWGGYAQSLLN---GGFVRP 703

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           + G H+D +HPPIHPT  +   SG   N   LYE + R FLAC SK ++  +TTV IDIA
Sbjct: 704 KEGKHNDNSHPPIHPTGAANALSGKQAN---LYEFICRRFLACCSKESIYGQTTVTIDIA 760

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E FSA G +++++ YL+VYP++     ++PTY VG+ FTP+ L L+   T  P  LSE 
Sbjct: 761 DETFSATGSMMIQQGYLEVYPYDKRYDKILPTYVVGETFTPSRLELNKSRTVAPKPLSEP 820

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +LLS MD   IGTDATM  HIKK++DR Y  K+   RF PT+LG+AL++GYD   M +  
Sbjct: 821 ELLSEMDNNKIGTDATMAQHIKKIIDRNYVIKNEENRFIPTDLGKALIIGYD--SMGFGF 878

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+  ++ G + K+ VL  ++ + K  F+ AR    ++     I F    
Sbjct: 879 SKPALRAKIEADVHKIATGNRKKEDVLKDTIQQYKTLFIQAR----EMSHMFDITFSNYF 934

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLP--GSVSEA 369
           R  G +       + +CG C  + + LK   D   ++ C     C  +  LP  G +   
Sbjct: 935 RPYGSQFRILQANLSKCGKCN-NKLDLKSTDDARRVLQC---KTCLASHMLPKVGDIVPY 990

Query: 370 AVTTNPCNF 378
             T   CNF
Sbjct: 991 DGTCPLCNF 999


>H2Z240_CIOSA (tr|H2Z240) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 753

 Score =  274 bits (701), Expect = 4e-71,   Method: Compositional matrix adjust.
 Identities = 142/307 (46%), Positives = 191/307 (62%), Gaps = 8/307 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 322 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGGP--QP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 380 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 436

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T   PLL+EA
Sbjct: 437 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRT-TAPLLTEA 495

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 496 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 553

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A     KL EA+S +F  + 
Sbjct: 554 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEAIQKADKLDEALSAYFGDAT 613

Query: 312 RSAGDEL 318
           R  G  L
Sbjct: 614 RVEGSNL 620


>E0VPP3_PEDHC (tr|E0VPP3) DNA topoisomerase OS=Pediculus humanus subsp. corporis
           GN=Phum_PHUM362520 PE=3 SV=1
          Length = 901

 Score =  273 bits (697), Expect = 1e-70,   Method: Compositional matrix adjust.
 Identities = 148/404 (36%), Positives = 223/404 (55%), Gaps = 15/404 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           LK AE+LY  G+ISYPRTET+ F    +L  +VQ Q     WG +A ++L        NP
Sbjct: 316 LKTAEKLYTQGYISYPRTETNIFPKELDLRPLVQRQTTDSNWGEFALKVLVDGP----NP 371

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             G   D+AHPPIHP K+++  +G  +N   +YEL+VRHFLAC+SK A G ET VEID+A
Sbjct: 372 NQGTKSDQAHPPIHPIKYASNLTGVEKN---IYELIVRHFLACLSKNAEGIETAVEIDLA 428

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E+F+A G +I  +NYLDVYP++ W    I  Y VG  F P A++L  G T PP LL+EA
Sbjct: 429 NEIFTAKGLMITARNYLDVYPYDVWNAKEINLYNVGDVFKP-AVSLVEGKTNPPELLTEA 487

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  DHI+ +  RFY        F P  LG  LV GY+++   +++
Sbjct: 488 DLIALMEKHGIGTDATHADHIETIKARFYVGLKNDKYFVPRTLGMGLVEGYNNV--GFEM 545

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+ S++   K    VL   ++K K  F   + N   L E ++ + Q +N
Sbjct: 546 AKPNLRAELEADLSSITRNEKMPQDVLNKHINKYKNIFEVVKTNSKNLFEIINSYIQGNN 605

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
             + ++ +   +    C  C   + ++K+ ++      C    QC N + +  +V +  +
Sbjct: 606 PISSEKENNVPKSPMNCREC--GNPMIKEIKNNKISFSCSNKSQCLNVINISNTVKDVEI 663

Query: 372 TTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEIL 415
           T + C  C             + +     ++  +GC+ GCD+ L
Sbjct: 664 TNDSCPKCGSNSKLLKFNFKNKNKN---RSVKDIGCLNGCDKNL 704


>H2Z237_CIOSA (tr|H2Z237) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 645

 Score =  271 bits (694), Expect = 3e-70,   Method: Compositional matrix adjust.
 Identities = 140/304 (46%), Positives = 189/304 (62%), Gaps = 8/304 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 350 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGG--PQP 407

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 408 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 464

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T  P  L+EA
Sbjct: 465 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRTTAPS-LTEA 523

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 524 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 581

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A     KL EA+S +F  + 
Sbjct: 582 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEAIQKADKLDEALSAYFGDAT 641

Query: 312 RSAG 315
           R  G
Sbjct: 642 RVEG 645


>H3J0J4_STRPU (tr|H3J0J4) DNA topoisomerase OS=Strongylocentrotus purpuratus PE=3
           SV=1
          Length = 626

 Score =  271 bits (693), Expect = 4e-70,   Method: Compositional matrix adjust.
 Identities = 140/302 (46%), Positives = 186/302 (61%), Gaps = 9/302 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    NL  ++++Q    +WG +A  LL        +P
Sbjct: 321 MKIAEKLYTQGFISYPRTETNIFPKELNLVPLIEKQTQDAQWGAFAGNLLQQGP----HP 376

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D AHPPIHPTK++    G   N +K+YEL+VRHFLAC S+ A G ET V I IA
Sbjct: 377 RQGKKTDHAHPPIHPTKYNGNLQG---NEQKVYELIVRHFLACCSQDAQGKETIVNITIA 433

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+A G +I+ +NYLDVYP+E W   +IP Y  GQ F PT+L +  G T+ PPLL+EA
Sbjct: 434 EEEFTATGLMIIARNYLDVYPYEKWNAKIIPVYDRGQTFEPTSLEMVDGQTQAPPLLTEA 493

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDK GIGTDAT  +HI+ +  R Y       RF P  LG  L  GYD+  M Y+L
Sbjct: 494 DLITLMDKHGIGTDATHAEHIETIKSRLYVGVRPDGRFVPGELGMGLCEGYDN--MGYEL 551

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +ESD+K +S+G K  + VLA  +DK K  F+ A      L  A+  +  +  
Sbjct: 552 SKPNLRAELESDLKRISDGQKNPEDVLAEQVDKYKQVFIEAARKATMLDSALEQYLGQPA 611

Query: 312 RS 313
           +S
Sbjct: 612 QS 613


>H2Z238_CIOSA (tr|H2Z238) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 650

 Score =  270 bits (691), Expect = 6e-70,   Method: Compositional matrix adjust.
 Identities = 139/301 (46%), Positives = 188/301 (62%), Gaps = 8/301 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 356 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGG--PQP 413

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 414 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 470

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T  P  L+EA
Sbjct: 471 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRTTAPS-LTEA 529

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 530 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 587

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A     KL EA+S +F  + 
Sbjct: 588 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEAIQKADKLDEALSAYFGDAT 647

Query: 312 R 312
           R
Sbjct: 648 R 648


>K3WHB4_PYTUL (tr|K3WHB4) Uncharacterized protein OS=Pythium ultimum
           GN=PYU1_G004346 PE=3 SV=1
          Length = 788

 Score =  270 bits (689), Expect = 1e-69,   Method: Compositional matrix adjust.
 Identities = 147/317 (46%), Positives = 197/317 (62%), Gaps = 10/317 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIY-AQRLLDPEAGLWRN 70
           +K AE LY  GF+SYPRTET+ F   T+L  +V+  +G+ +WG Y +Q+LL   AG +  
Sbjct: 320 MKAAESLYNKGFLSYPRTETNKFKEGTDLMGLVEMHEGNQQWGQYVSQQLLG--AGKYEP 377

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR GG DD+AHPPIHPTK  A  S      +K+YE V  HFLAC SK A G +T V++ I
Sbjct: 378 PRQGGADDQAHPPIHPTKSVALSSISDDIEKKVYEFVTLHFLACCSKDAKGHQTNVQMRI 437

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
             E F+A G +I E+NYLD+Y +E W  S IP Y  G  F P+ L + +G T PPPLLSE
Sbjct: 438 VDERFTASGLMIEERNYLDIYKYEKWNASAIPVYQQGDTFEPSTLMMTAGETAPPPLLSE 497

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAY 249
           ADL+S MD  GIGTDAT+ +HIK +L R YA K + +T+F PT LG ALV+ Y+  +M  
Sbjct: 498 ADLISKMDSNGIGTDATIAEHIKTILKREYAEKVNNNTQFKPTTLGLALVVSYE--QMGL 555

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-- 307
            L KP LR+AME+D K++S G K    V+   +++MK  FL+   N   L +  +  F  
Sbjct: 556 DLAKPALRAAMENDCKAISLGQKDCRQVVQACMNQMKEIFLNVNRNADVLDQTFAEHFNQ 615

Query: 308 --QRSNRSAGDELHATG 322
              +SN +  D+    G
Sbjct: 616 PVNKSNDNPRDQTETCG 632


>B9PMP6_TOXGO (tr|B9PMP6) DNA topoisomerase OS=Toxoplasma gondii GN=TGGT1_081640
           PE=3 SV=1
          Length = 677

 Score =  270 bits (689), Expect = 1e-69,   Method: Compositional matrix adjust.
 Identities = 137/281 (48%), Positives = 179/281 (63%), Gaps = 6/281 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE LYQ G ISYPRTET+ FSP  +L ++++   G   WG YAQ+L+D +  LW  P
Sbjct: 326 MSIAESLYQRGIISYPRTETEVFSPTMDLLSLIRVHIGSTAWGTYAQKLVDGDF-LW--P 382

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             G  DDKAHPPIHP K     S   +   KLYE V RHFLAC S+ A G ET VEIDIA
Sbjct: 383 SDGARDDKAHPPIHPLKL-MQRSELEEEEWKLYEFVTRHFLACCSEDAFGFETRVEIDIA 441

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  +LE+ +LDVYP+E W G+ +P + V ++  P+++ +    T PPPLL+EA
Sbjct: 442 GEGFYATGLTVLERRWLDVYPYEQWSGNRLPRFLVNERVMPSSILMSERQTEPPPLLTEA 501

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIE--MAY 249
           DL+  MDK GIGTDATMHDHI+ + DR Y  K+ + +F PT+LG AL  G+  +      
Sbjct: 502 DLIDLMDKNGIGTDATMHDHIRTIQDRHYCYKNENMQFVPTDLGVALYQGFKRLAEVSGV 561

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFL 290
            L  P+LR+ ME+DM  V+ G K K  VL   + +MK  FL
Sbjct: 562 DLSLPDLRARMEADMALVARGAKTKQEVLDLHVSEMKRVFL 602


>B6KEM8_TOXGO (tr|B6KEM8) DNA topoisomerase OS=Toxoplasma gondii GN=TGME49_026480
           PE=3 SV=1
          Length = 677

 Score =  270 bits (689), Expect = 1e-69,   Method: Compositional matrix adjust.
 Identities = 137/281 (48%), Positives = 179/281 (63%), Gaps = 6/281 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE LYQ G ISYPRTET+ FSP  +L ++++   G   WG YAQ+L+D +  LW  P
Sbjct: 326 MSIAESLYQRGIISYPRTETEVFSPTMDLLSLIRVHIGSTAWGTYAQKLVDGDF-LW--P 382

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             G  DDKAHPPIHP K     S   +   KLYE V RHFLAC S+ A G ET VEIDIA
Sbjct: 383 SDGARDDKAHPPIHPLKL-MQRSELEEEEWKLYEFVTRHFLACCSEDAFGFETRVEIDIA 441

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  +LE+ +LDVYP+E W G+ +P + V ++  P+++ +    T PPPLL+EA
Sbjct: 442 GEGFYATGLTVLERRWLDVYPYEQWSGNRLPRFLVNERVMPSSILMSERQTEPPPLLTEA 501

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIE--MAY 249
           DL+  MDK GIGTDATMHDHI+ + DR Y  K+ + +F PT+LG AL  G+  +      
Sbjct: 502 DLIDLMDKNGIGTDATMHDHIRTIQDRHYCYKNENMQFVPTDLGVALYQGFKRLAEVSGV 561

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFL 290
            L  P+LR+ ME+DM  V+ G K K  VL   + +MK  FL
Sbjct: 562 DLSLPDLRARMEADMALVARGAKTKQEVLDLHVSEMKRVFL 602


>H3G7Y5_PHYRM (tr|H3G7Y5) Uncharacterized protein (Fragment) OS=Phytophthora
           ramorum GN=gwEuk.87.105.1 PE=3 SV=1
          Length = 628

 Score =  269 bits (687), Expect = 2e-69,   Method: Compositional matrix adjust.
 Identities = 145/306 (47%), Positives = 193/306 (63%), Gaps = 7/306 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQR-LLDPEAGLWRN 70
           +K AE LY  GFISYPRTET  F   T+L ++V+  + H +WG Y  R LLD   G +  
Sbjct: 321 MKAAESLYNKGFISYPRTETSKFKEGTDLMSLVRLHETHQQWGNYVTRQLLD--GGKYEA 378

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G  DD+AHPPIHPTK     +    N +K+YE V  HFLAC S+ A G++T+V + I
Sbjct: 379 PRHGNSDDQAHPPIHPTKSIDVNTLRDPNEKKVYEFVALHFLACCSRDAKGSQTSVVMKI 438

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
            GE F+A G ++ E+NYLD+Y +E W  S IP Y  G  F P+ + + SG T PPPLLSE
Sbjct: 439 LGESFTASGLMVEERNYLDIYKYEKWNASAIPVYQRGDVFRPSTVVMLSGETNPPPLLSE 498

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAY 249
           ADL+S MD  GIGTDAT+ +HIK +L R Y+ K +  T+F PT LG ALV+ Y+   M  
Sbjct: 499 ADLISKMDSNGIGTDATIAEHIKTILKREYSIKVNNDTQFKPTTLGLALVLSYE--HMGL 556

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF-Q 308
           +L KP LR+AME+D K++S G K    V+ + +D+MK+ FL    +   L +  S  F Q
Sbjct: 557 ELAKPVLRAAMENDCKAISLGQKDVQQVVQSCMDQMKSIFLEVTRSASVLDQTFSEQFGQ 616

Query: 309 RSNRSA 314
            +N SA
Sbjct: 617 PANESA 622


>I1QMB1_ORYGL (tr|I1QMB1) DNA topoisomerase OS=Oryza glaberrima PE=3 SV=1
          Length = 1343

 Score =  266 bits (681), Expect = 1e-68,   Method: Compositional matrix adjust.
 Identities = 120/153 (78%), Positives = 135/153 (88%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +KVAEELYQ GFISYPRTETD+FSP  +LH+IV EQ  HP WGIYAQRLLDPEA LWRNP
Sbjct: 511 MKVAEELYQAGFISYPRTETDNFSPNIDLHSIVHEQVAHPNWGIYAQRLLDPEARLWRNP 570

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             GGHDDKAHPPIHPTKFSAGE+ W+ NH+KLYELVVRHFLAC S+PAVGAETTVEI+IA
Sbjct: 571 SNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEINIA 630

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTY 164
           GE F+A G V+L KNYLDVY F++WGG+L+PTY
Sbjct: 631 GEQFNASGLVVLAKNYLDVYRFDSWGGTLLPTY 663



 Score =  225 bits (573), Expect = 4e-56,   Method: Compositional matrix adjust.
 Identities = 108/176 (61%), Positives = 128/176 (72%), Gaps = 2/176 (1%)

Query: 250  KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
            +LWKP LRS ME+DMKSVS GTK K  VL   L +MKACFL AR NKVKL +AM  FF R
Sbjct: 982  ELWKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFAR 1041

Query: 310  SNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
            S+R   +  +   E VR C  C ES+M LK+   G FMVGC GFPQCRNAVWLP S+SEA
Sbjct: 1042 SSRPVNETQNV--ETVRPCAACNESEMFLKQRPTGEFMVGCRGFPQCRNAVWLPRSLSEA 1099

Query: 370  AVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEICGTG 425
            AVT   C  C PGPVY+IQ KFR+ +IPPN++++HLGCIGGCD+IL++L EI   G
Sbjct: 1100 AVTDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMEISRFG 1155


>G4YKY0_PHYSP (tr|G4YKY0) Putative uncharacterized protein OS=Phytophthora sojae
           (strain P6497) GN=PHYSODRAFT_470148 PE=3 SV=1
          Length = 916

 Score =  266 bits (680), Expect = 1e-68,   Method: Compositional matrix adjust.
 Identities = 147/314 (46%), Positives = 197/314 (62%), Gaps = 11/314 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIY-AQRLLDPEAGLWRN 70
           +K AE LY  GFISYPRTET  F   T+L ++V+  + H +WG Y AQ+LLD   G +  
Sbjct: 324 MKAAESLYNKGFISYPRTETSKFKEGTDLMSLVRLHENHQQWGNYVAQQLLD--GGKYEA 381

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G  DD+AHPPIHPTK     +    N +K+YE V RHFLAC S+ A G++T+V + +
Sbjct: 382 PRHGNSDDQAHPPIHPTKSVNVNTLSDPNEKKVYEFVTRHFLACCSRDAKGSQTSVVMRM 441

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
            GE F+A G ++ E+NYLD+Y +E W  S IP Y  G  F P+ + + SG T PPPLLSE
Sbjct: 442 LGESFTASGLMVEERNYLDIYKYEKWNASAIPVYQRGDVFHPSTVVMLSGETNPPPLLSE 501

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAY 249
           ADL++ MD  GIGTDAT+ +HIK +L R YA K +  T+F PT LG ALV+ Y+   M  
Sbjct: 502 ADLIAKMDSNGIGTDATIAEHIKTILKREYAIKVNNDTQFKPTTLGLALVLSYE--HMGL 559

Query: 250 KLWKPELRSA----MESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMS- 304
           +L KP LR+A    ME+D K++S G K    V+ + +D+MK+ FL    +   L +  S 
Sbjct: 560 ELAKPVLRAAVSRMMENDCKAISLGRKEIQQVVRSCMDQMKSIFLEVTRSAAVLDQTFSE 619

Query: 305 IFFQRSNRSAGDEL 318
            F Q  N+SA   L
Sbjct: 620 QFGQPVNQSAAPRL 633


>F0WXN1_9STRA (tr|F0WXN1) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2419

 Score =  265 bits (678), Expect = 2e-68,   Method: Compositional matrix adjust.
 Identities = 145/370 (39%), Positives = 209/370 (56%), Gaps = 10/370 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +   + +MKA F   + +     +A +  F+R+
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAIEACMQQMKAIFSSIQQSANVFDQAFTQVFRRN 644

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             +      +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   +A
Sbjct: 645 EPNLDSITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQISA 700

Query: 371 VTTN--PCNF 378
                  CNF
Sbjct: 701 YNYKCPLCNF 710


>F0WXN6_9STRA (tr|F0WXN6) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2383

 Score =  265 bits (678), Expect = 2e-68,   Method: Compositional matrix adjust.
 Identities = 145/370 (39%), Positives = 209/370 (56%), Gaps = 10/370 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +   + +MKA F   + +     +A +  F+R+
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAIEACMQQMKAIFSSIQQSANVFDQAFTQVFRRN 644

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             +      +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   +A
Sbjct: 645 EPNLDSITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQISA 700

Query: 371 VTTN--PCNF 378
                  CNF
Sbjct: 701 YNYKCPLCNF 710


>F0WXN7_9STRA (tr|F0WXN7) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2417

 Score =  265 bits (678), Expect = 2e-68,   Method: Compositional matrix adjust.
 Identities = 145/370 (39%), Positives = 209/370 (56%), Gaps = 10/370 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +   + +MKA F   + +     +A +  F+R+
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAIEACMQQMKAIFSSIQQSANVFDQAFTQVFRRN 644

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             +      +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   +A
Sbjct: 645 EPNLDSITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQISA 700

Query: 371 VTTN--PCNF 378
                  CNF
Sbjct: 701 YNYKCPLCNF 710


>F0WXN8_9STRA (tr|F0WXN8) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2392

 Score =  265 bits (677), Expect = 2e-68,   Method: Compositional matrix adjust.
 Identities = 145/370 (39%), Positives = 209/370 (56%), Gaps = 10/370 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +   + +MKA F   + +     +A +  F+R+
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAIEACMQQMKAIFSSIQQSANVFDQAFTQVFRRN 644

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             +      +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   +A
Sbjct: 645 EPNLDSITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQISA 700

Query: 371 VTTN--PCNF 378
                  CNF
Sbjct: 701 YNYKCPLCNF 710


>F0WXP0_9STRA (tr|F0WXP0) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2356

 Score =  265 bits (677), Expect = 2e-68,   Method: Compositional matrix adjust.
 Identities = 145/370 (39%), Positives = 209/370 (56%), Gaps = 10/370 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +   + +MKA F   + +     +A +  F+R+
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAIEACMQQMKAIFSSIQQSANVFDQAFTQVFRRN 644

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             +      +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   +A
Sbjct: 645 EPNLDSITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQISA 700

Query: 371 VTTN--PCNF 378
                  CNF
Sbjct: 701 YNYKCPLCNF 710


>F0WXN4_9STRA (tr|F0WXN4) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2390

 Score =  265 bits (677), Expect = 3e-68,   Method: Compositional matrix adjust.
 Identities = 145/370 (39%), Positives = 209/370 (56%), Gaps = 10/370 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +   + +MKA F   + +     +A +  F+R+
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAIEACMQQMKAIFSSIQQSANVFDQAFTQVFRRN 644

Query: 311 NRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAA 370
             +      +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   +A
Sbjct: 645 EPNLDSITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQISA 700

Query: 371 VTTN--PCNF 378
                  CNF
Sbjct: 701 YNYKCPLCNF 710


>H2Z241_CIOSA (tr|H2Z241) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 755

 Score =  264 bits (674), Expect = 6e-68,   Method: Compositional matrix adjust.
 Identities = 136/301 (45%), Positives = 187/301 (62%), Gaps = 12/301 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 322 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGGP--QP 379

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 380 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 436

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T   PLL+EA
Sbjct: 437 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRT-TAPLLTEA 495

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 496 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 553

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A    ++  +   +  Q+S 
Sbjct: 554 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEA----IQKADNQPVVSQQSQ 609

Query: 312 R 312
           R
Sbjct: 610 R 610


>D2VSX3_NAEGR (tr|D2VSX3) Predicted protein OS=Naegleria gruberi
           GN=NAEGRDRAFT_81118 PE=3 SV=1
          Length = 1015

 Score =  263 bits (673), Expect = 8e-68,   Method: Compositional matrix adjust.
 Identities = 156/371 (42%), Positives = 209/371 (56%), Gaps = 20/371 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSP--RTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           +KVAE LY  GFISYPRTET++++     +L  +V E   +P WG YA  LL+   G ++
Sbjct: 343 MKVAESLYNKGFISYPRTETNNYNQFQDDDLKRLVNEHTSNPTWGGYASDLLN---GGYQ 399

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            P  G  DDKAHPPIHP K     +      + LYEL+ RHFLAC SK AVGAET V I 
Sbjct: 400 KPPSGKQDDKAHPPIHPLKGDCNSN--DSKEQALYELIARHFLACCSKDAVGAETKVIIS 457

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IA E F+  G ++ +KN+L+++ ++ W    IP +  GQ+F PT+L +D G TRPPP LS
Sbjct: 458 IANEEFTCSGLMVEQKNFLEIWKYDRWSDKSIPVFNAGQEFIPTSLLMDHGETRPPPHLS 517

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           E+DL+S MD  GIGTDAT+  HIK + +R Y  K  + RF  TNLG AL+ GYD I   Y
Sbjct: 518 ESDLISAMDSNGIGTDATVAQHIKTIQERGYVIKKGN-RFEATNLGMALLQGYDLI--GY 574

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
           +L  P LRS ME DM S+S+G + K+AV+  SL   K  ++    +   L +A+   F  
Sbjct: 575 ELSTPNLRSKMEKDMLSISKGEQSKEAVIHQSLSMYKHVYIQICKSAYLLDKAVQQHFPT 634

Query: 310 SNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEA 369
                   L       R   LC   + +  K +DGN  + C     C ++  LP S SE 
Sbjct: 635 LGEGQSRVLG------RGFSLCSCKNPMDLKEQDGNNFLHC---KNCSDSYPLP-SKSEY 684

Query: 370 AVTTNPCNFCT 380
               + C  C 
Sbjct: 685 ESIEDVCPICN 695



 Score = 76.6 bits (187), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 37/93 (39%), Positives = 55/93 (59%), Gaps = 4/93 (4%)

Query: 324 VVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFCT--P 381
           VVR+C  C  + +V ++  D +  +GC GFP C++AVWLP S+ +A +TT  CN C+   
Sbjct: 752 VVRKCQKCSNNLVVRQRKNDTSLYIGCKGFPNCKSAVWLPKSIEKADLTTEKCNRCSTRS 811

Query: 382 GPVYRIQLKFRQ-LEIPPNYNINHLGCIGGCDE 413
             VYR++  F Q   +PP  N  H  C+  CD+
Sbjct: 812 DTVYRLKFTFAQGTLLPPGVNREHTTCV-FCDQ 843


>K0TAA4_THAOC (tr|K0TAA4) Uncharacterized protein (Fragment) OS=Thalassiosira
           oceanica GN=THAOC_03864 PE=3 SV=1
          Length = 948

 Score =  263 bits (673), Expect = 8e-68,   Method: Compositional matrix adjust.
 Identities = 150/336 (44%), Positives = 200/336 (59%), Gaps = 10/336 (2%)

Query: 11  FLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQG-HPEWGIYAQRLLDPEAGLWR 69
            ++ AE LY  G+ISYPRTET+ F P  N H ++Q     + E G YAQ LL      ++
Sbjct: 406 LMQKAESLYNNGYISYPRTETERFRPEFNHHDLIQSFHAVNGELGNYAQLLLSNNN--FQ 463

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           NPR G +DD AHPPI P K    E       R +Y LVV+H+LAC S+ AVG ET + + 
Sbjct: 464 NPRAGPNDDNAHPPITPAKAVNPEEIADPIERNIYSLVVKHYLACCSRDAVGRETELTLK 523

Query: 130 IAGELFSACGRVILEKNYLDVY-PFETW--GGSLIPTYTVGQQFTPTALTLDSGVTRPPP 186
           IA E FSA G +ILE+N+L++Y P+E W  G  ++P   VG + TPT+L +  G T PP 
Sbjct: 524 IASEEFSAKGLMILERNWLEIYHPWEKWSTGQGVLPKARVGTRITPTSLMMRDGATAPPN 583

Query: 187 LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIE 246
           L+SE +L+S MDK GIGTDAT+  HI  +LDR Y  KDAS RF P  LG ALV GY+   
Sbjct: 584 LISEVELISAMDKNGIGTDATIAQHITTILDRGYCVKDASQRFNPNPLGIALVEGYNS-- 641

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           M ++L KP+LR +ME++  ++++G K K+AVL + + +M  CF  A     KL EAM   
Sbjct: 642 MGHQLNKPDLRRSMEAECNAIADGRKTKEAVLGSVVLQMLQCFNEANAKAAKLDEAMERH 701

Query: 307 FQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKNR 342
           F R   +   +         RCG C    M LK+ R
Sbjct: 702 FGRLG-TGNSQYSVLQGNFSRCGNC-NGMMTLKQVR 735


>B3RSB2_TRIAD (tr|B3RSB2) Putative uncharacterized protein OS=Trichoplax
           adhaerens GN=TRIADDRAFT_22834 PE=3 SV=1
          Length = 625

 Score =  263 bits (672), Expect = 9e-68,   Method: Compositional matrix adjust.
 Identities = 137/296 (46%), Positives = 186/296 (62%), Gaps = 10/296 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  GFISYPRTET+ F    NL  +++ Q    EWG +A+ L+  E G    P
Sbjct: 317 MKIAEKLYNRGFISYPRTETNQFPSSMNLRQLIEYQTESSEWGDFAKSLV--ERG--PTP 372

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D AHPPIHPTKF+    G   N +++YELVVRHFLAC S+ A G+ET VEI IA
Sbjct: 373 RWGKKTDNAHPPIHPTKFTNTLQG---NEKRIYELVVRHFLACCSQDAEGSETIVEITIA 429

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            ELF+  G +I+ KNYL+VYP++ W    +P +  GQQF PT +++  G T PPPLL+E+
Sbjct: 430 RELFAVQGLIIIAKNYLEVYPYDRWSDKPLPAFVEGQQFQPTNISMVEGRTEPPPLLTES 489

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L+  MDK GIGTDAT  +HI+ +  R Y     + RF P  LG  LV GYD   M +++
Sbjct: 490 NLIDLMDKNGIGTDATHAEHIETIKARKYVAVQ-NGRFVPGELGIGLVEGYDS--MGFEM 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF 307
            KP+LR+ +E+ +K + EGT+ K  VL   + K K  F+ A     KL  A+S + 
Sbjct: 547 SKPKLRAELEAGLKRICEGTRNKTEVLQEQITKYKEVFVKAAAEATKLDVALSKYL 602


>J9J536_9SPIT (tr|J9J536) DNA topoisomerase OS=Oxytricha trifallax
           GN=OXYTRI_17611 PE=3 SV=1
          Length = 894

 Score =  263 bits (671), Expect = 1e-67,   Method: Compositional matrix adjust.
 Identities = 142/416 (34%), Positives = 226/416 (54%), Gaps = 53/416 (12%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           ++  E+LY+  +ISYPRTET+ + P  NL  I+QE     ++  + ++LL  E   +  P
Sbjct: 274 MEYMEDLYRKAYISYPRTETNVYHPTINLRRIIQELNNDKDYSGFTKKLL--ELNNYGGP 331

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWS--QNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           R G  DDKAHPPIHP +F   E   +   N  K+Y+++ RHFLA VSK AV  ET V+I 
Sbjct: 332 RNGKQDDKAHPPIHPVRFMKEEDKVNLPPNQVKVYDMICRHFLASVSKDAVAQETVVKIQ 391

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           I  E     G ++ +KNYL+++PF+TW  +L+P + VG+Q T  +L +    T+PP  LS
Sbjct: 392 IGEEQLQTQGLIVEKKNYLEIFPFDTWDSTLLPDFKVGEQITYDSLKVAKTTTKPPQYLS 451

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           E+DL+  MD+ GIGTDAT+H+HIKK+ +R YA      +F PT LG++L+  Y+  E+  
Sbjct: 452 ESDLIDTMDQNGIGTDATIHEHIKKIQERQYAMVQGK-KFKPTLLGQSLIDAYE--EIGV 508

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF--LHARLNKVK--------- 298
            + KP LR+ ME +M+ ++EG K KD  L  +L +M+  +  +  +++++K         
Sbjct: 509 DIHKPYLRAQMEREMRLIAEGKKSKDEFLKETLTQMEGVYDQVSGKVDQIKNYLQVNYKQ 568

Query: 299 --------------------LLEAMSIFFQRSNRSA--------------GDELHATGEV 324
                               L ++ ++ F +  +                G++       
Sbjct: 569 QFDDMYTLDEKEGVFRFSGDLGDSQNLNFNQEKKQQEIVKQVLGENSQERGNKNSIANTK 628

Query: 325 VRRCGLCQESDMVLK-KNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFC 379
           + +C  C ++DMV+    + GN   GC GFP+C N + +P S+ +A V+   C  C
Sbjct: 629 ICKCYKCNKNDMVMMISGKTGNPFFGCQGFPKCINPLPVPRSILKAEVSNESCPSC 684


>I4YDJ6_WALSC (tr|I4YDJ6) DNA topoisomerase OS=Wallemia sebi (strain ATCC
           MYA-4683 / CBS 633.66) GN=WALSEDRAFT_51054 PE=3 SV=1
          Length = 797

 Score =  263 bits (671), Expect = 2e-67,   Method: Compositional matrix adjust.
 Identities = 133/296 (44%), Positives = 188/296 (63%), Gaps = 9/296 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           +  K+AE+LYQ GF+SYPRTETD + P  + H+++ +Q     WG YA+ L D  +G  +
Sbjct: 283 RVTKIAEKLYQKGFLSYPRTETDQYDPSFDFHSLIDKQANDGVWGSYARSLTD--SGFDK 340

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT  ++G +G   N +++YE + R FLA  S+ A G  T  E++
Sbjct: 341 -PREGKKNDKAHPPIHPTAHASGLTG---NDKRVYEYITRRFLASCSRDAKGKNTNAEVE 396

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE+F A G V+LEKNYL+V+P++ W    IP +TVGQ FTP+   L  G T PP LL+
Sbjct: 397 IAGEIFKASGSVLLEKNYLNVFPYDKWSSHTIPNFTVGQVFTPSVCELREGKTTPPNLLT 456

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT--KDASTRF-TPTNLGEALVMGYDDIE 246
           EADL+S MDK GIGTDAT+ +HI K++DR Y    K  +T++  P+ LG ALV GY+ + 
Sbjct: 457 EADLVSLMDKHGIGTDATIAEHIHKIIDREYVMEHKQGNTKYLVPSTLGVALVEGYNKMN 516

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEA 302
           +   + KP+LR   E  M  + EG   K  VL  S+D+ K  ++ +      L+E+
Sbjct: 517 LEKSVSKPQLRRENEERMNRIGEGLVEKTDVLIESIDQYKDIYIRSARQFQVLVES 572


>F4PE38_BATDJ (tr|F4PE38) Putative uncharacterized protein (Fragment)
           OS=Batrachochytrium dendrobatidis (strain JAM81 / FGSC
           10211) GN=BATDEDRAFT_14853 PE=3 SV=1
          Length = 612

 Score =  261 bits (668), Expect = 3e-67,   Method: Compositional matrix adjust.
 Identities = 129/298 (43%), Positives = 198/298 (66%), Gaps = 7/298 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + ++VAE LY  G +SYPRTETD F  + +L  ++++Q    EWG YA  LL+   G + 
Sbjct: 305 RVMQVAEALYNRGIVSYPRTETDCFDDKFDLMPLIEKQTQSQEWGSYAASLLN---GKFT 361

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++D+AHPPIHP + +   SG   + +K+++ + R FLAC S  A G ET V+++
Sbjct: 362 KPRKGKNNDQAHPPIHPVRAAFDLSG---DEKKVFDYITRRFLACCSAAARGQETVVDLE 418

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           ++ E F++ G +ILE+NYL+V+P+E W  S IPT++VG++  P+ L +  G T  P +L+
Sbjct: 419 LSQEKFTSSGLMILERNYLEVFPYEKWSDSDIPTFSVGERVEPSLLEMREGSTTRPTMLT 478

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EADL++ MDK GIGTDAT+H+HIKK+LDR YA K+ +  F PT LG ALV  YD++++  
Sbjct: 479 EADLITLMDKSGIGTDATIHEHIKKILDREYARKE-NIYFFPTTLGMALVTAYDEMDIDL 537

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF 307
            L +P LRS  E++MK + +G + ++ V++ S++  K  F+ A     KL E+ + FF
Sbjct: 538 SLSRPFLRSLTEANMKKICDGARQREDVVSESIELYKNVFIAAFGQASKLHESCAKFF 595


>L7LY29_9ACAR (tr|L7LY29) DNA topoisomerase OS=Rhipicephalus pulchellus PE=2 SV=1
          Length = 669

 Score =  261 bits (668), Expect = 3e-67,   Method: Compositional matrix adjust.
 Identities = 143/324 (44%), Positives = 192/324 (59%), Gaps = 11/324 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           ++VAE+LY  GFISYPRTET  F P  NL  +V+ Q   P WG +A+RLL  + GL   P
Sbjct: 318 MQVAEKLYTDGFISYPRTETTKFPPDLNLRPLVEAQAQDPRWGDFARRLL--QDGL--TP 373

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHP K + G  G   N +++YELVVRHFLAC+SK A G ETTVE+D+ 
Sbjct: 374 RQGNKTDQAHPPIHPVKSAPGLDG---NAKRVYELVVRHFLACLSKDAEGKETTVEVDLN 430

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G VI  +NYL+VY ++ W G  IP+Y  G+ F P ++ +  G T PPPLL EA
Sbjct: 431 GERFIATGLVIFARNYLEVYIYDKWNGKEIPSYQEGECFVPDSVKMAEGETTPPPLLREA 490

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ M+K GIGTDAT  +HI+ + +R Y          P  LG  LV GYD   M  ++
Sbjct: 491 DLIALMEKHGIGTDATHAEHIETVKNRLYVALTGDGYLVPGELGMGLVEGYDS--MGLEM 548

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KP LR+ +E+D+K + EG K    VL   ++  +  F  +     KL EA+  +     
Sbjct: 549 SKPHLRAELEADLKKICEGVKNAKDVLRHQVNLYRDVFYDSERQIKKLGEALKRYLGTGQ 608

Query: 312 RSAGDELHATGEVVRRCGLCQESD 335
           RS+     A  +   R G  Q+S+
Sbjct: 609 RSSSPP--APRQNNARAGSVQDSN 630


>H2Z243_CIOSA (tr|H2Z243) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 633

 Score =  260 bits (665), Expect = 6e-67,   Method: Compositional matrix adjust.
 Identities = 132/281 (46%), Positives = 178/281 (63%), Gaps = 8/281 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 210 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGGP--QP 267

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 268 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 324

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T  P  L+EA
Sbjct: 325 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRTTAPS-LTEA 383

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 384 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 441

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHA 292
            +PELR+ +E+D++ + +GT  K+ VL   +   ++ F  A
Sbjct: 442 SRPELRAELEADLRRICDGTANKNDVLQRHISTYRSVFQEA 482


>L1LDB1_BABEQ (tr|L1LDB1) DNA topoisomerase OS=Babesia equi GN=BEWA_052950 PE=3
           SV=1
          Length = 622

 Score =  259 bits (663), Expect = 1e-66,   Method: Compositional matrix adjust.
 Identities = 132/296 (44%), Positives = 183/296 (61%), Gaps = 4/296 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTET+ F    +L +++     HP +G YA+RL+D   G +  P
Sbjct: 314 MQLAESLYSKGFISYPRTETNIFPQSIDLMSLINSLSNHPTFGEYAKRLVD---GDFCVP 370

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             G  +D+AHPPIHP K        S  H +LYE + R FLAC SK AVG E+ + +D++
Sbjct: 371 VMGKKNDEAHPPIHPVKSMTSSEAESPLHWQLYEYITRRFLACCSKAAVGDESMIFLDVS 430

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F   G VI E N+LD+Y +E W G ++P ++ GQ+ TPT +TL +G T PP LLSEA
Sbjct: 431 GEGFHTKGMVIREYNWLDIYTYEKWEGRIVPNFSQGQEITPTKITLKNGKTNPPALLSEA 490

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDD-IEMAYK 250
           +L+  M+K GIGTDATMH+HI+K+ DR YA K+   RF PTNLG+AL   + +    +  
Sbjct: 491 NLIDLMNKNGIGTDATMHEHIQKIQDRHYAVKNEKLRFIPTNLGKALYNAFKEYTASSID 550

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           L KP LR+ ME DM  ++ G K K+ V+    D M+  +L          +AMS+ 
Sbjct: 551 LTKPALRAHMERDMSDIACGLKNKEDVVRVYADLMRDIYLEIANQPDYFNDAMSML 606


>J9FV51_9SPIT (tr|J9FV51) DNA topoisomerase OS=Oxytricha trifallax
           GN=OXYTRI_20606 PE=3 SV=1
          Length = 955

 Score =  259 bits (663), Expect = 1e-66,   Method: Compositional matrix adjust.
 Identities = 133/289 (46%), Positives = 184/289 (63%), Gaps = 13/289 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++ E+LYQ G +SYPRTET++F+P  NL  IV E      +G +AQR+ D    +W  P
Sbjct: 325 MEIMEKLYQRGILSYPRTETNTFNPTINLRNIVNELCKSEVFGDFAQRISD--GSMWGGP 382

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           + G  DDKAHPPIHP KF A +     +  ++YELV RHFLA +SK A+GAET +E+   
Sbjct: 383 KNGKQDDKAHPPIHPVKF-ASKQDLGFDEWRVYELVARHFLATISKDAIGAETCIEVSCG 441

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQF--TPTALTLDSGVTRPPPLLS 189
           GE F   G +I E+N+L+V+P+E W  S +P    G+ F      L +  G TRPPPLL+
Sbjct: 442 GEQFQTKGLIIEEQNWLEVFPYEKWSDSYLPQLNKGESFEVNNQNLKIQDGETRPPPLLT 501

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EADL++ MD+ GIGTDAT+H+HIK + +R YA K   T F P+ LG  LV  Y+   +  
Sbjct: 502 EADLITKMDQNGIGTDATIHEHIKHIQERQYAYKQGQT-FLPSPLGTNLVEAYE--HLGI 558

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVK 298
           +L+KP LR+ ME DMK ++EG K KD VL   +++M+  F     N+VK
Sbjct: 559 ELYKPYLRAQMEKDMKMIAEGIKSKDQVLRDCVNEMRRIF-----NRVK 602


>E5SGH1_TRISP (tr|E5SGH1) DNA topoisomerase OS=Trichinella spiralis GN=Tsp_06572
           PE=3 SV=1
          Length = 870

 Score =  258 bits (659), Expect = 4e-66,   Method: Compositional matrix adjust.
 Identities = 156/399 (39%), Positives = 220/399 (55%), Gaps = 27/399 (6%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + VAE+LY  G+ISYPRTET+ F    +L ++V++     +WG +A R+L         P
Sbjct: 312 MAVAEKLYTQGYISYPRTETNFFPKEIDLVSLVKQHVNDSQWGTFANRVLSQGV----QP 367

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D AHPPIHP +    E    Q HR+LYE VVRHFLAC+S  A G +TTVEI++A
Sbjct: 368 RQGNKTDNAHPPIHPIRHVDLEQFQHQQHRRLYEFVVRHFLACISADAQGLQTTVEIEVA 427

Query: 132 GELFSACGRVILEKNYLDVY-PFETWG-GSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
            E FSA G ++ E+NYL+VY P+E W    L   Y VG +F    + + +G T+PP LL+
Sbjct: 428 DEQFSASGLIVTERNYLEVYHPYENWSEKQLDVAYAVGDRFD-VQVEMVTGETKPPNLLT 486

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EADL+  M+K GIGTDAT  +HI+ +  R Y    A  R  P  LG  LV GYD I    
Sbjct: 487 EADLIGLMEKFGIGTDATHAEHIETIQKRLYVGLTADKRLLPGFLGLGLVDGYDAI--GC 544

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
           +L KP+LR+  E++++ +++G++ K  VL     K    F+       +L +A+S +F  
Sbjct: 545 QLAKPDLRADFETELRRIADGSRSKQDVLGEYKAKYWHVFMQVTAMAERLDQALSAYFDS 604

Query: 310 --------------SNRSA-GDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFP 354
                         +N SA   E      V  RC  C  S M LK+ R+G + VGC  +P
Sbjct: 605 GTGPSTVAVSGPSDNNYSARRQEQRQLDNVCTRCLSCGNS-MRLKQTRNGIYFVGCENYP 663

Query: 355 QCRNAVWLPG--SVSEAAVTTNPCNFCTPGPVYRIQLKF 391
            C+ A+WL     +  A+V  + C++CT      I+LK 
Sbjct: 664 SCKEAIWLDQRERIQFASVLADRCDWCTLRQTRLIELKL 702


>B8BZX1_THAPS (tr|B8BZX1) DNA topoisomerase (Fragment) OS=Thalassiosira
           pseudonana GN=top3a PE=3 SV=1
          Length = 672

 Score =  258 bits (658), Expect = 5e-66,   Method: Compositional matrix adjust.
 Identities = 146/338 (43%), Positives = 198/338 (58%), Gaps = 9/338 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQG-HPEWGIYAQRLLDPEAGLW 68
           + ++ AEELYQ GFISYPRTET+ F P  + HA++Q  Q    E+G YA  LL      +
Sbjct: 340 ELMQKAEELYQQGFISYPRTETEKFRPEFDHHALIQSFQAVQGEFGNYATSLLSNSN--F 397

Query: 69  RNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEI 128
           +NPR G +DD AHPPI P K    ++      RK+Y LVV+H+LAC S+ AVG ET + +
Sbjct: 398 QNPRAGQNDDNAHPPITPAKAVDPQTIADPIQRKVYTLVVKHYLACCSRDAVGRETELTL 457

Query: 129 DIAGELFSACGRVILEKNYLDVY-PFETW--GGSLIPTYTVGQQFTPTALTLDSGVTRPP 185
            IA E F A G +ILE+N+L++Y PFE W  G   +P   VG +  PT L ++ G T  P
Sbjct: 458 KIASEEFVAKGLMILERNWLEIYQPFERWSTGQGELPKVRVGSRIVPTTLVMNEGQTSAP 517

Query: 186 PLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI 245
             +SE +L+S MD+ GIGTDAT+  HI  + +R YA KD + RF PT LG ALV GY+  
Sbjct: 518 TPISEVELISLMDRNGIGTDATIAQHITTICEREYAKKDQNQRFHPTKLGIALVEGYNS- 576

Query: 246 EMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSI 305
            M Y+L KP+LR  ME++  +V+ G K KD +L   + KM  CF  A     KL  A++ 
Sbjct: 577 -MGYQLNKPDLRREMEAECSAVAAGRKTKDQILGPVIAKMLHCFRTANAEVEKLDTAVAR 635

Query: 306 FFQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKNRD 343
            F +   +  +E          CG C    M LK+ R+
Sbjct: 636 HFDKLGSNRNNEYSVLQADFSVCGTCNRM-MTLKEQRN 672


>K9HST2_AGABB (tr|K9HST2) DNA topoisomerase OS=Agaricus bisporus var. bisporus
           (strain H97 / ATCC MYA-4626 / FGSC 10389)
           GN=AGABI2DRAFT_154568 PE=3 SV=1
          Length = 703

 Score =  257 bits (656), Expect = 9e-66,   Method: Compositional matrix adjust.
 Identities = 133/283 (46%), Positives = 180/283 (63%), Gaps = 9/283 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L +AE+LYQ GF+SYPRTETD F P+ +  +++Q+Q+    WG +AQ L   E G + 
Sbjct: 314 KVLDIAEKLYQQGFVSYPRTETDQFDPQFDFMSLIQKQKADTNWGNFAQSL---EQGGFT 370

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           +PR G HDDKAHPPIHPT  +   +G   + +++YE + R FLAC SK A G +TTVE+ 
Sbjct: 371 SPRKGKHDDKAHPPIHPTAHAGNLTG---DEKRVYEYIARRFLACCSKDAEGWQTTVEVV 427

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             GE F A G VIL+ NYLDVYP++ W    IP Y  G+ F PT   + SG T  P LL+
Sbjct: 428 CGGEFFHATGLVILKTNYLDVYPYDKWSDHPIPEYKEGESFRPTCCEMRSGKTSKPQLLT 487

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK--DASTRF-TPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+  HI+ ++DR Y  +  + ST++  P+ LG ALV GYD I 
Sbjct: 488 EADLVTLMDKNGIGTDATIAQHIQTIVDREYVIERMEGSTKYLVPSTLGVALVEGYDQIG 547

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
           +   + KP+LR   E  M  V + T  K A+L  +L++ K  F
Sbjct: 548 LDRSVSKPQLRRETERRMVLVGQRTITKQAMLDQALEQYKEMF 590


>K5WXT1_AGABU (tr|K5WXT1) DNA topoisomerase OS=Agaricus bisporus var. burnettii
           (strain JB137-S8 / ATCC MYA-4627 / FGSC 10392)
           GN=AGABI1DRAFT_46203 PE=3 SV=1
          Length = 852

 Score =  256 bits (655), Expect = 1e-65,   Method: Compositional matrix adjust.
 Identities = 134/289 (46%), Positives = 182/289 (62%), Gaps = 9/289 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L +AE+LYQ GF+SYPRTETD F P+ +  +++Q+Q+    WG +AQ L   E G + 
Sbjct: 314 KVLDIAEKLYQQGFVSYPRTETDQFDPQFDFMSLIQKQKADTNWGNFAQSL---EQGGFT 370

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           +PR G HDDKAHPPIHPT  +   +G   + +++YE + R FLAC SK A G +TTVE+ 
Sbjct: 371 SPRKGKHDDKAHPPIHPTAHAGNLTG---DEKRVYEYIARRFLACCSKDAEGWQTTVEVV 427

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             GE F A G VIL+ NYLDVYP++ W    IP Y  G+ F PT   + SG T  P LL+
Sbjct: 428 CGGEFFHATGLVILKTNYLDVYPYDKWSDHPIPEYKEGESFRPTCCEMRSGKTSKPQLLT 487

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK--DASTRF-TPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+  HI+ ++DR Y  +  + ST++  P+ LG ALV GYD I 
Sbjct: 488 EADLVTVMDKNGIGTDATIAQHIQTIVDREYVIERMEGSTKYLVPSTLGVALVEGYDQIG 547

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
           +   + KP+LR   E  M  V + T  K A+L  +L++ K  F   + N
Sbjct: 548 LDRSVSKPQLRRETERRMVLVGQRTITKQAMLDQALEQYKEMFRVVKGN 596


>B7G3B1_PHATC (tr|B7G3B1) DNA topoisomerase OS=Phaeodactylum tricornutum (strain
           CCAP 1055/1) GN=PHATRDRAFT_47417 PE=3 SV=1
          Length = 1009

 Score =  256 bits (654), Expect = 1e-65,   Method: Compositional matrix adjust.
 Identities = 145/340 (42%), Positives = 204/340 (60%), Gaps = 12/340 (3%)

Query: 11  FLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQG-HPEWGIYAQRLLDPEAGLWR 69
            +  AEELYQ G+ISYPRTET+ F P      ++Q+      E+G YA +LL+ E G ++
Sbjct: 395 LMSAAEELYQQGYISYPRTETERFRPEFEHRPLIQQFSSLQGEFGAYASKLLN-ENG-FQ 452

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  DD+AHPPI P K     +   Q  RK+Y L+V+H+LAC S+ AVG  TT+ + 
Sbjct: 453 IPRAGKSDDQAHPPITPAKAVDPNTIQDQIQRKIYSLIVKHYLACCSRDAVGRGTTLTVR 512

Query: 130 IAGELFSACGRVILEKNYLDVY-PFETWGGSL--IPTYTVGQQFTPTALTLDSGVTRPPP 186
           +  E F+A G +++EKN+L++Y P+E WG     +P   VG +  PT+  +  G + PP 
Sbjct: 513 MGTEEFNATGLMVIEKNWLEIYSPWERWGSGQGELPPLQVGSRIRPTSFLMKEGRSGPPQ 572

Query: 187 LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIE 246
            +SE +L+S MD+ GIGTDAT+  HI  +LDR YA KD   +F PT LG ALV GY+   
Sbjct: 573 PISEVELISLMDRNGIGTDATIAQHISTILDREYARKDGRQKFLPTPLGIALVEGYNS-- 630

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           M Y+L KP+LR  ME++   V+ G K K+ ++   L KMK+C+  AR    KL EA++  
Sbjct: 631 MGYQLNKPDLRREMEAECNEVASGRKTKEEIMVPILAKMKSCYETARAEARKLDEAVARH 690

Query: 307 FQRSNRSAGDEL-HATGEVVRRCGLCQESDMVLKKNRDGN 345
           F R    AG+       E    CG+C+ S M LK+ R+ N
Sbjct: 691 FPRLG--AGESTSQVVEESFSECGVCRNS-MALKQERENN 727


>Q01CA7_OSTTA (tr|Q01CA7) DNA topoisomerase III alpha, putative (ISS)
           OS=Ostreococcus tauri GN=Ot03g03950 PE=3 SV=1
          Length = 842

 Score =  256 bits (654), Expect = 1e-65,   Method: Compositional matrix adjust.
 Identities = 164/457 (35%), Positives = 234/457 (51%), Gaps = 55/457 (12%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +K+AE+LY  GFISYPRTETD F    N    +++   HP++G Y  +L++   G +R
Sbjct: 323 QIMKIAEDLYNDGFISYPRTETDKFPADFNYDGTLRDLHPHPQFGFYVDQLIN--GGRFR 380

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGW------SQNHRKLYELVVRHFLACVSKPAVGAE 123
            P GGG DDKAHPPI+PTK  A E+ +      +Q+  K+YE VVRHFLA  S PA+  +
Sbjct: 381 QPPGGGKDDKAHPPIYPTKL-ASEAQYQQMRAKNQHAPKVYEFVVRHFLATCSHPAIAMK 439

Query: 124 TTVEIDIAGELFSACGRVILEKNYLDVY------------PFETWGGSLIPTYTVGQQFT 171
           T V+I +AGE F A G +I E+NYLD+Y             ++ WG S +P YT G+QF 
Sbjct: 440 THVDIVVAGETFRATGVMIRERNYLDIYGPGPPEGPRLAPAYDNWGNSTLPLYTPGEQFV 499

Query: 172 PTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLL-DRFYATKDASTRFT 230
           P AL+L  G TRPP  LSE DLLS M+   IGTDAT   HI+K++ +R YA K    R T
Sbjct: 500 P-ALSLHEGQTRPPDYLSEVDLLSLMESHMIGTDATQAQHIEKVVGERGYARKVGDNRLT 558

Query: 231 PTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFL 290
           PT LGEALV+ YD + +A  +W P  R+ ME+D+ +V++     +A L   L  M   + 
Sbjct: 559 PTQLGEALVLAYDRMGVA-DMWLPTKRAKMEADVDAVAKNRLDPNAGLRAHLQAMLDAYD 617

Query: 291 HARLNKVKLLEAMSIFFQRSNRSA----------GDELHATGE--------VVR-RCGLC 331
               + + L   +  F    + +A          G++++  G         V+R  C  C
Sbjct: 618 RVAADGLTLTTTVGAFMNGQDNAANGVGHRPMPPGNDINGNGADAFGDLIGVIRDTCPSC 677

Query: 332 QESDMVLKKN--RDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQL 389
           Q    +      R+    +     P C + + +P    +  +    C  C       +  
Sbjct: 678 QGESTLRSAPGVRNSKSFIASCAVPHCMSRIAMPSCTRDIKIEQEGCGRCQG---RLLTF 734

Query: 390 KFRQLEIPPNYNINHL----GCIGGCDEILRQLTEIC 422
           KF  L +P  Y   H+    GCI  CD   + L   C
Sbjct: 735 KFSTLYLPVGY--QHMQRWSGCI-FCDAEFQNLLRAC 768


>J9J1U5_9SPIT (tr|J9J1U5) DNA topoisomerase OS=Oxytricha trifallax
           GN=OXYTRI_11120 PE=3 SV=1
          Length = 1033

 Score =  255 bits (652), Expect = 2e-65,   Method: Compositional matrix adjust.
 Identities = 129/281 (45%), Positives = 180/281 (64%), Gaps = 8/281 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +++AE+LYQ G+ISYPRTET+ F P  NL  IV++   +  +G YA+++L     L+ 
Sbjct: 434 KAMEIAEKLYQRGYISYPRTETNIF-PAMNLQEIVKDLTKNTTFGGYAKKILS--GNLYG 490

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  DDKAHPPIHP K +A +     +  ++YE++ +HFLAC+SK A G ET +E++
Sbjct: 491 TPRKGKQDDKAHPPIHPVK-NANKMDLKHDEWRIYEIICKHFLACLSKDATGNETKIEVE 549

Query: 130 IAGELFSACGRVILEKNYLDVY-PFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLL 188
           I GE F   G VI+E N+L++Y P+E W  + +P +  G QFTP+ + +    T+PP LL
Sbjct: 550 IGGETFKTRGLVIVESNWLEIYQPYEKWADNTLPNFQEGDQFTPSLIQMQESQTQPPKLL 609

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMA 248
           SEADL+S MDK GIGTDAT+H+HIK + DR YA K     F PT LG  LV  YD +   
Sbjct: 610 SEADLISRMDKNGIGTDATIHEHIKTIQDRGYALKQGQ-HFIPTQLGLNLVNAYDHV--G 666

Query: 249 YKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
            +L+KP LRS +E  +K +  G + K  VL   L +M+  F
Sbjct: 667 IELFKPNLRSQVERQLKEIEYGNRNKKEVLKECLREMRRIF 707


>H2Z242_CIOSA (tr|H2Z242) DNA topoisomerase (Fragment) OS=Ciona savignyi PE=3
           SV=1
          Length = 584

 Score =  255 bits (652), Expect = 2e-65,   Method: Compositional matrix adjust.
 Identities = 129/267 (48%), Positives = 172/267 (64%), Gaps = 8/267 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE LY  G+ISYPRTET+SF    NL  +VQEQ  HP+WG +A RLL    G    P
Sbjct: 319 MKIAESLYTQGYISYPRTETNSFPKDFNLERLVQEQTSHPDWGGFASRLLGLNGG--PQP 376

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK +   +G   N+ ++YEL+ RHFLAC  + A G ET+VEI++ 
Sbjct: 377 RNGHKSDQAHPPIHPTKAAPHLTG---NNARIYELITRHFLACCHRDAKGQETSVEIEVG 433

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE FS  G +I+E+NYL+VY ++ W G +I  Y +G QF PT + + SG T  P   +EA
Sbjct: 434 GESFSVQGLMIIERNYLEVYHYDRWNGKIIAVYEIGDQFEPTDVRMTSGRTTAPS-HTEA 492

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MDK GIGTDAT  +HI+ +  R Y       RF P  LG  LV GYD   M Y +
Sbjct: 493 DLISLMDKHGIGTDATHAEHIETIKQRMYVGLTNDQRFLPGELGMGLVEGYD--LMGYAM 550

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVL 278
            +PELR+ +E+D++ + +GT  K+ VL
Sbjct: 551 SRPELRAELEADLRRICDGTANKNDVL 577


>F8PV61_SERL3 (tr|F8PV61) DNA topoisomerase OS=Serpula lacrymans var. lacrymans
           (strain S7.3) GN=SERLA73DRAFT_52441 PE=3 SV=1
          Length = 875

 Score =  255 bits (652), Expect = 2e-65,   Method: Compositional matrix adjust.
 Identities = 131/304 (43%), Positives = 188/304 (61%), Gaps = 9/304 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L +AE+LYQ GF+SYPRTETD F P+ +   ++ +Q   P WG +A  L   + G + 
Sbjct: 314 KVLDIAEKLYQQGFLSYPRTETDQFDPQFDFMHLIAKQTADPAWGGFATSL---QEGGFN 370

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++DKAHPPIHPT   A  +G   + +K+YE + R FLAC SK A G+ETTV+++
Sbjct: 371 VPRKGKNNDKAHPPIHPTAHVANLAG---DEKKVYEYIARRFLACCSKDAEGSETTVDVE 427

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             GE F   G VIL++NYL+VYP++ W    IP +  G++F PT   +  G T  P LL+
Sbjct: 428 YGGEQFYVTGLVILQRNYLEVYPYDKWSSKEIPEFREGEEFGPTVCEVREGQTSAPSLLT 487

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK--DASTR-FTPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+  HI+ ++DR Y  +  + ST+   P+ LG  L+ GY+ I 
Sbjct: 488 EADLVTLMDKNGIGTDATIAQHIQTIVDREYVIERMEGSTKHLIPSTLGIGLIEGYNQIG 547

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
               L KP+LR   E  M  V EG K K  +LA S+D+ K  F+ A+    K++ ++  +
Sbjct: 548 FDRSLSKPQLRRQTERSMAQVCEGNKSKGDMLAESIDQYKEMFITAKREFEKVVASVRRY 607

Query: 307 FQRS 310
            +R+
Sbjct: 608 IERN 611


>R9AS06_WALIC (tr|R9AS06) DNA topoisomerase 3 OS=Wallemia ichthyophaga EXF-994
           GN=J056_003403 PE=4 SV=1
          Length = 887

 Score =  255 bits (651), Expect = 3e-65,   Method: Compositional matrix adjust.
 Identities = 130/305 (42%), Positives = 185/305 (60%), Gaps = 9/305 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L +AE+LYQ GF+SYPRTETD + P  N  +++++Q  +  WG YAQ L   +   + 
Sbjct: 322 QVLDIAEKLYQQGFLSYPRTETDQYDPSFNFESLIEKQTANSTWGEYAQSL---QFDRFD 378

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT  +   SG   N +++YEL+ R FLA  SK A G  TT E++
Sbjct: 379 RPRNGKKNDKAHPPIHPTAHAPSLSG---NEKRVYELITRRFLASCSKDAKGKNTTAELE 435

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           +AGE+F A G V++EKNYL+VY +E W    IP +  G+ F P+   L  G T PP LL+
Sbjct: 436 MAGEIFKASGSVLIEKNYLEVYIYEKWSNQTIPNFEQGEVFQPSICELREGKTTPPTLLT 495

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT--KDASTRF-TPTNLGEALVMGYDDIE 246
           EADL+S MDK GIGTDAT+ +HI K++DR Y    K  ST++  P+ LG ALV GY+ + 
Sbjct: 496 EADLVSLMDKNGIGTDATIAEHIHKIIDREYVMEHKLGSTKYLVPSTLGVALVEGYNKMN 555

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
                 KP+LR   E  M  + EG   K  VL  S+++ +  +  + L    L+ ++  +
Sbjct: 556 FDKSFAKPQLRRENEEKMNMIGEGIAQKSDVLLESINQYRDIYNRSALQFATLVNSVKHY 615

Query: 307 FQRSN 311
            Q ++
Sbjct: 616 LQNAD 620


>Q55KM2_CRYNB (tr|Q55KM2) DNA topoisomerase OS=Cryptococcus neoformans var.
           neoformans serotype D (strain B-3501A) GN=CNBJ3110 PE=3
           SV=1
          Length = 1059

 Score =  255 bits (651), Expect = 3e-65,   Method: Compositional matrix adjust.
 Identities = 125/287 (43%), Positives = 179/287 (62%), Gaps = 9/287 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L +AE+LYQ G +SYPRTETD + P+ + ++++Q+Q    +WG YAQ+LLD   G ++
Sbjct: 322 RILDLAEKLYQKGIVSYPRTETDQYDPKFDFNSLIQKQTLDNQWGAYAQKLLD---GAFQ 378

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT  +    G   + R+++EL+ R FLA  S  A G  TTVEI 
Sbjct: 379 KPRNGRKNDKAHPPIHPTAHAGNLEG---DERRVFELITRRFLASCSTNAEGQNTTVEIS 435

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IA E+FS  G V+L +NYL+VYP++ W    +P +  G+ F P  + L  G T  P LL+
Sbjct: 436 IADEIFSTTGLVVLRRNYLEVYPYDKWATHALPNFEEGEVFIPDVIDLKEGTTSRPSLLT 495

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR---FTPTNLGEALVMGYDDIE 246
           EADL+  MDK GIGTDAT+ +HI K+++R Y T+    R     P+ LG  LV G++ I 
Sbjct: 496 EADLVGLMDKNGIGTDATIAEHIAKIIERGYVTEKQEARIKYLVPSTLGIGLVEGFNAIG 555

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR 293
               L KP LR   E  M+ + +G +GK  +L T++++ K  F+ AR
Sbjct: 556 FDRSLSKPHLRRETEHRMQLICDGVRGKREILQTTIEEYKEVFVKAR 602


>E6R530_CRYGW (tr|E6R530) DNA topoisomerase OS=Cryptococcus gattii serotype B
           (strain WM276 / ATCC MYA-4071) GN=CGB_D9400W PE=3 SV=1
          Length = 923

 Score =  254 bits (649), Expect = 4e-65,   Method: Compositional matrix adjust.
 Identities = 126/287 (43%), Positives = 179/287 (62%), Gaps = 9/287 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L +AE+LYQ G +SYPRTETD + P+ + ++++Q+Q    +WG YAQ+LLD   G ++
Sbjct: 322 RILDLAEKLYQRGIVSYPRTETDQYDPKFDFNSLIQKQTLDNQWGAYAQKLLD---GAFQ 378

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT  +    G   + R+++EL+ R FLA  S  A G  TTVEI 
Sbjct: 379 KPRNGRKNDKAHPPIHPTAHAGNLDG---DERRVFELITRRFLASCSTNAEGQNTTVEIS 435

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IA E+FS  G V+L +NYL+VYP++ W    +P +  G+ F P  + L  G T  P LL+
Sbjct: 436 IADEIFSTTGLVVLRRNYLEVYPYDKWATHALPNFEEGEVFIPDVVDLKEGTTSRPSLLT 495

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR---FTPTNLGEALVMGYDDIE 246
           EADL+  MDK GIGTDAT+ +HI K+++R Y T+    R     P+ LG  LV G++ I 
Sbjct: 496 EADLVGLMDKNGIGTDATIAEHIAKIIERGYVTEKQEARIKYLVPSTLGVGLVEGFNAIG 555

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR 293
               L KP LR   E  M+ + +G +GK  +L T+L++ K  F+ AR
Sbjct: 556 FDRSLSKPHLRRETEHRMQLICDGVRGKGEILQTTLEEYKEVFVKAR 602


>E9CIX7_CAPO3 (tr|E9CIX7) DNA topoisomerase OS=Capsaspora owczarzaki (strain ATCC
           30864) GN=CAOG_08067 PE=3 SV=1
          Length = 874

 Score =  254 bits (648), Expect = 7e-65,   Method: Compositional matrix adjust.
 Identities = 134/293 (45%), Positives = 182/293 (62%), Gaps = 7/293 (2%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           LK AE LY  GF+SYPRT+TD F    +L A+   Q  HPEWG +  + +        NP
Sbjct: 288 LKTAESLYTQGFLSYPRTDTDVFPETMDLTALANMQANHPEWGSFVHQYILARGP---NP 344

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G ++D+AHPPIHPTK  A  S  + + +KLYELV R FLA +S  A G  T VEID+A
Sbjct: 345 RKGKNNDEAHPPIHPTK-PAPASFQNADEKKLYELVTRSFLATLSSDAQGHLTNVEIDVA 403

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  ILE+NYL VYP++ W    +P +  G +F P  + +D+G T PPPLL+E+
Sbjct: 404 GERFRANGLAILERNYLLVYPYDVWSNHTLPPFREGDRFQPAEVRMDAGSTTPPPLLTES 463

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
            LL+ M + GIGTDATMH+HIKK+L+R YA       F PTNLG  L+ GYD   M  ++
Sbjct: 464 ALLTLMHQHGIGTDATMHEHIKKVLERKYAEMRGQM-FLPTNLGLGLIEGYD--SMGLEM 520

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMS 304
            KP +R+ ME++M  +  G + K  V+ ++LD     F+ A   +  L++A+S
Sbjct: 521 SKPHMRARMEAEMLKICSGQQTKAQVIRSTLDLYLPAFMDACRQRRMLVDALS 573


>F0ZSL6_DICPU (tr|F0ZSL6) Putative uncharacterized protein OS=Dictyostelium
           purpureum GN=DICPUDRAFT_37309 PE=3 SV=1
          Length = 831

 Score =  253 bits (647), Expect = 8e-65,   Method: Compositional matrix adjust.
 Identities = 141/365 (38%), Positives = 208/365 (56%), Gaps = 11/365 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE+LY  G ISYPRTETD+F   T+   ++  Q  HP+WG YAQRL +   G ++ P
Sbjct: 330 MAIAEDLYNKGLISYPRTETDTFQQGTDFRGLIGIQGSHPQWGQYAQRLNN---GEFKYP 386

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G ++D +HPPIHPT  +A  S      +K+YE + R FLAC S  +V   T+V I+I 
Sbjct: 387 RSGTNNDNSHPPIHPT--AACPSTLPDRSKKVYEFITRRFLACCSTESVLGNTSVTIEIE 444

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F   G ++ E  YL+VYP++      IP Y  G++F    + L +G T+PP  L+E+
Sbjct: 445 GEQFVETGVMVKEWGYLEVYPYDKRSNKTIPKYRKGERFQVKRIELYNGTTQPPHFLTES 504

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +LLS MDK  IGTDATM  HI+ + DR Y  K+  ++F PT LG +LV  Y+   M ++ 
Sbjct: 505 ELLSAMDKNKIGTDATMATHIQTIQDRGYVIKNQESQFEPTKLGISLVASYE--LMGFQF 562

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSN 311
            KPELR+ +ESD+  +S+G K K+ VL T++++ K  F  A  N      + + F+Q + 
Sbjct: 563 SKPELRAQIESDVNEISKGRKQKEEVLRTTIERYKELFEIAFQNTDCFDRSFTQFYQLAE 622

Query: 312 RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAV 371
           +      H     +  CG C  + M  K +R+       L  P C+++  LP      A+
Sbjct: 623 QRTN--FHIEKPQLVLCGKCN-NKMDFKSDRNQETPKRILSCPTCKDSFDLPVKGEIGAL 679

Query: 372 T-TNP 375
           T T+P
Sbjct: 680 TETDP 684


>G7YVP7_CLOSI (tr|G7YVP7) DNA topoisomerase (Fragment) OS=Clonorchis sinensis
           GN=CLF_112022 PE=3 SV=1
          Length = 1106

 Score =  253 bits (647), Expect = 9e-65,   Method: Compositional matrix adjust.
 Identities = 154/417 (36%), Positives = 215/417 (51%), Gaps = 67/417 (16%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTET+ F P  +L  +V+ Q     W  +A R+L    G+  NP
Sbjct: 288 MQLAERLYTRGFISYPRTETNIFPPNLDLAELVRVQTHDNRWSDFASRIL--RTGV--NP 343

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   DKAHPPIHP K  AG  G   +  +L+EL+ RHFLAC+S  A GAET V + + 
Sbjct: 344 RNGKSTDKAHPPIHPLKAGAGLQG---DEARLFELITRHFLACISADAQGAETLVRLCVG 400

Query: 132 ------------------GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPT 173
                             GE+F A G VIL+ NYL+VY ++ W    +P + +G    PT
Sbjct: 401 KPSVPDASSRSTLLSSEDGEIFDAKGLVILQSNYLEVYIYDRWVERDMPDFQLGAWLLPT 460

Query: 174 ALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTN 233
            + + SG T PPPLL+EADL++ MD+ GIGTDAT  +HI+ +  R Y   +      P  
Sbjct: 461 NIEILSGQTSPPPLLTEADLIALMDRHGIGTDATHAEHIETIKQRLYVGLEQGKFLVPGQ 520

Query: 234 LGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR 293
           LG  LV GYD   M +++ KP LR+ +E+D++ + +G K KD VL   L+K K  F  A 
Sbjct: 521 LGMGLVEGYD--SMGFEMSKPHLRAELEADLRLICDGRKTKDEVLHRHLEKYKRLFQQAV 578

Query: 294 LNKVKLLEAMSIFFQRSNRSAGDELHATGEV---------------VRRCGLCQESDMVL 338
               +L +A+++  ++   +  D   + GE+               V  C  C  + +VL
Sbjct: 579 AQAFRLDQALAVRLEQPAENVSDMTGSIGEISAISGQHSCDTLTSHVTTCPSCSRA-VVL 637

Query: 339 KKNR------------DGNF------------MVGCLGFPQCRNAVWLPGSVSEAAV 371
           K+ R            D NF             + C G+P CR AVW P SV  A V
Sbjct: 638 KQKRSPQHPLSEVPSNDSNFSSRSDTGRANSWFLSCTGYPLCRYAVWFPDSVVHARV 694


>G4VM01_SCHMA (tr|G4VM01) Putative prokaryotic DNA topoisomerase OS=Schistosoma
           mansoni GN=Smp_158140 PE=3 SV=1
          Length = 1058

 Score =  253 bits (647), Expect = 9e-65,   Method: Compositional matrix adjust.
 Identities = 157/420 (37%), Positives = 217/420 (51%), Gaps = 63/420 (15%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  GFISYPRTET  F P  +L ++V  Q     W  +A R+L  E G   NP
Sbjct: 340 MQLAERLYNKGFISYPRTETKIFPPDLDLKSLVHVQINDSRWSDFATRIL--ERG--PNP 395

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           + G   DKAHPPIHP K      G   +  +LYELV RHFLAC+S  A GAET V + I 
Sbjct: 396 KNGKSSDKAHPPIHPLKVGDSLQG---DEARLYELVTRHFLACLSTDAEGAETIVRLCID 452

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GELF + G +IL  NYL+VY ++ W    +P + +G+   P  + + +G T PPPLL+EA
Sbjct: 453 GELFESKGLMILALNYLEVYIYDRWAEKDMPVFQLGEWILPDNIQVLTGQTCPPPLLTEA 512

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL+S MD+ GIGTDAT  +HI+ +  R Y   + +    P  LG  LV GYD   M +++
Sbjct: 513 DLISLMDRHGIGTDATHAEHIETIKQRLYVGLEQNKFLVPGQLGMGLVEGYD--SMGFEM 570

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLE-AMSIFFQRS 310
            KP LRS  E+D+K + EG K K+ VL   L+K K  F  A LN+   L+ A+++  ++ 
Sbjct: 571 SKPNLRSEFEADLKLICEGRKTKEEVLHHHLNKYKELFRLA-LNQASFLDRALALRLEQE 629

Query: 311 NRSAGDELHATGE----------------------VVRRCGLCQESDMVLKKNR------ 342
             +  +   + GE                      VV  C  C  S +VL++ R      
Sbjct: 630 AENVQNISGSVGEMASFAASNNTIDGHNQSNVLNPVVAFCPTCH-SGLVLRQKRSALRPL 688

Query: 343 -------------------DGNFMVGCLGFPQCRNAVWLPGSVSEAAVTT----NPCNFC 379
                              +G + + C G+P CR A+W P SV    V +    N CN C
Sbjct: 689 TTSSNLSNNSGSNEVNQTSNGGWFLSCSGYPNCRYAIWFPDSVIHVRVLSETNENTCNRC 748


>F0WXN9_9STRA (tr|F0WXN9) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2385

 Score =  253 bits (645), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 144/372 (38%), Positives = 204/372 (54%), Gaps = 19/372 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +       +AC    R  +      M  F   S
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAI-------EACMQQVRPPRCFGTNLMDSFVDES 637

Query: 311 N--RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           +  +   +   +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   
Sbjct: 638 DILKHTTNITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQI 693

Query: 369 AAVTTN--PCNF 378
           +A       CNF
Sbjct: 694 SAYNYKCPLCNF 705


>J9W0N6_CRYNH (tr|J9W0N6) DNA topoisomerase OS=Cryptococcus neoformans var.
           grubii serotype A (strain H99 / ATCC 208821 / CBS 10515
           / FGSC 9487) GN=CNAG_04600 PE=3 SV=1
          Length = 959

 Score =  253 bits (645), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 125/287 (43%), Positives = 177/287 (61%), Gaps = 9/287 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L +AE+LYQ G +SYPRTETD + P+   + ++Q+Q    +WG YAQ+LLD   G ++
Sbjct: 322 QILDLAEKLYQKGIVSYPRTETDQYDPKFEFNPLIQKQTLDNQWGAYAQKLLD---GAFQ 378

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT  +    G   + R+++EL+ R FLA  S  A G  TTVEI 
Sbjct: 379 RPRNGRKNDKAHPPIHPTAHAGNLEG---DERRVFELITRRFLASCSANAEGQNTTVEIS 435

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IA E+FS  G V+L +NYL+VYP++ W    +P +  G+ F P  + L  G T  P LL+
Sbjct: 436 IADEIFSTTGLVVLRRNYLEVYPYDKWATHALPNFEEGEVFIPNVIDLKEGTTSRPSLLT 495

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR---FTPTNLGEALVMGYDDIE 246
           EADL+  MDK GIGTDAT+ +HI K+++R Y T+    R     P+ LG  LV G++ I 
Sbjct: 496 EADLVGLMDKNGIGTDATIAEHIAKIIERGYVTEKQEARIKYLVPSTLGVGLVEGFNAIG 555

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR 293
               L KP LR   E  M+ + +G +GK  +L T++++ K  F+ AR
Sbjct: 556 FDRSLSKPHLRRETEHRMQLICDGVRGKREILQTTIEEYKEVFVKAR 602


>F0WXN5_9STRA (tr|F0WXN5) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2387

 Score =  252 bits (644), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 144/372 (38%), Positives = 204/372 (54%), Gaps = 19/372 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +       +AC    R  +      M  F   S
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAI-------EACMQQVRPPRCFGTNLMDSFVDES 637

Query: 311 N--RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           +  +   +   +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   
Sbjct: 638 DILKHTTNITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQI 693

Query: 369 AAVTTN--PCNF 378
           +A       CNF
Sbjct: 694 SAYNYKCPLCNF 705


>F0WXN3_9STRA (tr|F0WXN3) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2412

 Score =  252 bits (644), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 144/372 (38%), Positives = 204/372 (54%), Gaps = 19/372 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +       +AC    R  +      M  F   S
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAI-------EACMQQVRPPRCFGTNLMDSFVDES 637

Query: 311 N--RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           +  +   +   +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   
Sbjct: 638 DILKHTTNITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQI 693

Query: 369 AAVTTN--PCNF 378
           +A       CNF
Sbjct: 694 SAYNYKCPLCNF 705


>B6K7U4_SCHJY (tr|B6K7U4) DNA topoisomerase OS=Schizosaccharomyces japonicus
           (strain yFS275 / FY16936) GN=SJAG_04816 PE=3 SV=1
          Length = 621

 Score =  252 bits (644), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 126/290 (43%), Positives = 173/290 (59%), Gaps = 13/290 (4%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L++AE LY  GF+SYPRTETD F P  +L  ++ +Q   P WG +A  LL   +G +R
Sbjct: 314 KTLEIAEHLYTNGFVSYPRTETDQFDPGMDLQTLISKQTSDPSWGTFASDLL---SGNFR 370

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
           NPR G H+DKAHPPIHP       +  SQ+H K+Y+ + R FLAC S  A GAET VE+ 
Sbjct: 371 NPRSGSHNDKAHPPIHPIAHVTQNALPSQDHWKVYQFITRRFLACCSDHARGAETIVEVT 430

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
           +  E FS  G  +LE NYLDVY +E W  S  +P Y +  +F P  + +  G T  P  L
Sbjct: 431 MGDEQFSQSGLTVLEHNYLDVYIYEKWNSSAQLPVYEMNDEFVPRQVNIIEGATTSPTYL 490

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDAS---------TRFTPTNLGEALV 239
           +E +L+S MD  GIGTDATM +HI+K+ +R Y  K            + F PT+LG ALV
Sbjct: 491 TEPELISLMDANGIGTDATMAEHIEKVQEREYVLKRKRKGKGSGAGVSEFVPTSLGVALV 550

Query: 240 MGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
            GYD+I + + L KP LR  ME  +K++ +G   K+ ++  +L + +  F
Sbjct: 551 KGYDEIGLEWSLTKPFLRREMEVQLKNIEKGQSSKNVLVEVTLTQFRDVF 600


>F0WXN2_9STRA (tr|F0WXN2) DNA topoisomerase putative OS=Albugo laibachii Nc14
           GN=AlNc14C359G10974 PE=3 SV=1
          Length = 2414

 Score =  252 bits (644), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 144/372 (38%), Positives = 204/372 (54%), Gaps = 19/372 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K AE LY  GFISYPRTET  F   T+L  +++    H  WG Y    L  +   +  P
Sbjct: 348 MKAAENLYNKGFISYPRTETSKFKEGTDLINLIKLHSNHSSWGRYVTEEL-IQGNKYERP 406

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  DD+AHPPIHPTK +   S      +K+YEL+V HFLAC SK A G +T V + + 
Sbjct: 407 RNGTTDDEAHPPIHPTKAAELNSLNEMAEKKVYELIVLHFLACCSKDAKGFQTNVTMQMH 466

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F+  G +I E+NYL++Y FE W  S IP Y + +QF P  + ++SG T PP LL+EA
Sbjct: 467 MEEFTTSGLMITERNYLEIYRFEKWSNSSIPVYALREQFIPNCIRMESGETTPPSLLTEA 526

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYK 250
           DL++ MD  GIGTDAT+ +HIK +L R YA K + +  F PT LG ALV  Y  ++M + 
Sbjct: 527 DLIAKMDSNGIGTDATIAEHIKTILKREYAVKINGNMHFKPTQLGLALVQAY--VQMGFD 584

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L KP LR+AME+D K++S G K     +       +AC    R  +      M  F   S
Sbjct: 585 LAKPRLRAAMEADCKAISSGYKDPKTAI-------EACMQQVRPPRCFGTNLMDSFVDES 637

Query: 311 N--RSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSE 368
           +  +   +   +    +  CG+C +S M+L++ ++ +  + C     C    +LP +   
Sbjct: 638 DILKHTTNITSSISRALSSCGIC-DSKMILQQVQNRSTQLTC---HTCCQTYFLPAAQQI 693

Query: 369 AAVTTN--PCNF 378
           +A       CNF
Sbjct: 694 SAYNYKCPLCNF 705


>B6A9W0_CRYMR (tr|B6A9W0) DNA topoisomerase OS=Cryptosporidium muris (strain
           RN66) GN=CMU_040700 PE=3 SV=1
          Length = 843

 Score =  252 bits (643), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 132/325 (40%), Positives = 189/325 (58%), Gaps = 30/325 (9%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE LYQ G+ISYPRTET+SF    +L  I++EQ  H  WG YA  L+  +   + NP
Sbjct: 376 MNIAENLYQKGYISYPRTETNSFPESMDLKVIIREQINHQTWGRYASLLISNDK--YCNP 433

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D++HPPIHP K        S    KLYEL+ RHFLA  S  A+G E+ V +DIA
Sbjct: 434 RCGNSSDESHPPIHPVKCLDQNEATSAEEWKLYELITRHFLAVCSDDAIGQESVVILDIA 493

Query: 132 GELFSACGRVILEKNYLDVY-PFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           GE F A G V+LE+N+LD+Y P+E W G+++P +  G + TP ++ L    T PP L++E
Sbjct: 494 GEQFKAKGLVVLEENWLDIYKPYERWCGNVLPEFNQGDKLTPYSIFLSQSKTEPPHLITE 553

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI----- 245
           A+L+  MDK GIGTDATMH+HI+K+  R Y  K+  ++  PT+LG AL +G+++I     
Sbjct: 554 AELIDLMDKNGIGTDATMHEHIEKIQTRQYVIKNPRSQLIPTSLGYALALGFEEISKEAN 613

Query: 246 --------------------EMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKM 285
                               +    L +P LRSAME  MK +S G   +  V+A  LD M
Sbjct: 614 KIEQRDGLLLASDSSRNSICKFDKNLIRPNLRSAMEFSMKEISGGILNRSTVVAEILDSM 673

Query: 286 KACFLHARLNKVKLLE-AMSIFFQR 309
           K  +    ++ ++ L+ +  ++F R
Sbjct: 674 KYIY-QTMVHSIRFLDNSFKLYFPR 697


>A0CUH3_PARTE (tr|A0CUH3) Chromosome undetermined scaffold_28, whole genome
           shotgun sequence OS=Paramecium tetraurelia
           GN=GSPATT00010640001 PE=3 SV=1
          Length = 947

 Score =  251 bits (642), Expect = 3e-64,   Method: Compositional matrix adjust.
 Identities = 124/276 (44%), Positives = 171/276 (61%), Gaps = 7/276 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +++AE+LY  GFISYPRTET+ F P  NL  I+++Q  HP WG +AQ L++     + 
Sbjct: 318 KAMELAEKLYNRGFISYPRTETNKFPPTINLQNIIRDQVNHPVWGEFAQSLINCN---FD 374

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  DDKAHPPIHP K        +Q   ++Y+L+ RHFLAC SK A G+ETTV + 
Sbjct: 375 QPRAGNKDDKAHPPIHPVKMMRESDAQTQQEWEIYQLITRHFLACCSKNAKGSETTVNLQ 434

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           +  E F   G VILEKNYL++YP++ W  S +P Y  G     T L + +G T PP  ++
Sbjct: 435 VQEESFYKQGLVILEKNYLEIYPYDEWSQSQVPNYKKGDMIQIT-LKIQNGKTSPPKPMT 493

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           E++L+  MDK GIGTDAT+H+HI  + +R YA K       PT LG ALV  Y+   + +
Sbjct: 494 ESELIGLMDKNGIGTDATIHEHINTIQEREYAIKKGQI-IKPTKLGLALVESYE--MLGF 550

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKM 285
            L KP LR+ ME  M  V++GTK K  ++  ++ +M
Sbjct: 551 TLHKPHLRAVMEQRMNEVAQGTKQKKQIVEATIAEM 586


>M7XAM1_RHOTO (tr|M7XAM1) DNA topoisomerase III OS=Rhodosporidium toruloides NP11
           GN=RHTO_02390 PE=4 SV=1
          Length = 1011

 Score =  251 bits (641), Expect = 5e-64,   Method: Compositional matrix adjust.
 Identities = 130/302 (43%), Positives = 181/302 (59%), Gaps = 8/302 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L++AE LY  G +SYPRTETD F    N H ++ + +G   WG +A  LLD   G + 
Sbjct: 319 RVLEIAESLYHKGILSYPRTETDQFDRDFNFHELITQHKGDNAWGTFATNLLD--NGGFE 376

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT+     +G   + +++Y+LVVR FL C SK A G ETT EI+
Sbjct: 377 RPRNGKKNDKAHPPIHPTQHVNNLTG---DDKRVYDLVVRRFLGCCSKNAKGLETTCEIE 433

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE FSA G VI E+NYLDVY ++ W G+ +P + VG++F P  L+L  G+T  P LL+
Sbjct: 434 IAGEAFSAKGLVIRERNYLDVYIYDKWTGNHLPEFQVGERFEPDELSLKEGMTTQPSLLT 493

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYA--TKDASTRF-TPTNLGEALVMGYDDIE 246
           EADL+S MDK GIGTDAT+ +HI K++DR Y    K+ S  +  P+ LG  LV  YD + 
Sbjct: 494 EADLVSLMDKNGIGTDATIAEHISKIIDREYVIKQKEGSVEYLVPSTLGIGLVKAYDALG 553

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           +   L KP LR   E  +  + EG K K  V+  SL++ +      +      +  +  +
Sbjct: 554 LENSLSKPHLRRLTEERLVQICEGKKNKADVITQSLNEYREVLFRTQQQMAAFVATVRQY 613

Query: 307 FQ 308
            +
Sbjct: 614 VE 615


>J4CDC9_THEOR (tr|J4CDC9) DNA topoisomerase III OS=Theileria orientalis strain
           Shintoku GN=TOT_030000183 PE=3 SV=1
          Length = 619

 Score =  250 bits (639), Expect = 7e-64,   Method: Compositional matrix adjust.
 Identities = 126/283 (44%), Positives = 178/283 (62%), Gaps = 8/283 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +++AE LY  G+ISYPRTET+ F    N+  I++      E+  YA  LL+   G +R
Sbjct: 311 KCMQLAEALYNKGYISYPRTETNCFPSSINVKTIIRMLSTVQEFSGYANTLLN---GGFR 367

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            P  G  +D+AHPPIHP K  +     S+ H +LYE + R FLAC SK ++G ++ V +D
Sbjct: 368 EPIKGRKNDEAHPPIHPVKCLSRYEADSEEHWQLYEYIARRFLACCSKASIGHQSIVILD 427

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           ++GE+F+  G +I E+N+L++Y + TW G LIP +   QQ  P A+ L  G T PP LLS
Sbjct: 428 VSGEMFNLKGLIIHERNWLNIYTYSTWEGKLIPNFHENQQIMPDAILLKDGRTTPPSLLS 487

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EA+L+  M++ GIGTDATMH+HI+K+ DR Y  KD + RF PTNLG+A+  G+   E  Y
Sbjct: 488 EANLIDLMNRNGIGTDATMHEHIQKIQDRHYCVKDQNLRFIPTNLGKAIYHGFK--EYNY 545

Query: 250 K---LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
           +   L KP LR+ ME DM  +S G K K+ V+    + MK+ F
Sbjct: 546 RNIDLTKPILRAKMEKDMSDISVGIKDKNQVIVKYSNIMKSIF 588


>M2RFS6_CERSU (tr|M2RFS6) DNA topoisomerase OS=Ceriporiopsis subvermispora B
           GN=CERSUDRAFT_50044 PE=3 SV=1
          Length = 1000

 Score =  250 bits (638), Expect = 9e-64,   Method: Compositional matrix adjust.
 Identities = 134/324 (41%), Positives = 191/324 (58%), Gaps = 16/324 (4%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L +AE LYQ GF+SYPRTETD F P+ +   ++ +Q   P WG +A  L   + G + 
Sbjct: 364 KVLDIAERLYQQGFLSYPRTETDQFDPKFDFATLIGKQAADPAWGGFATAL---QGGGFS 420

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  DDKAHPPIHPT  +A  +G   + +++YE + R FLAC SK A+G ETTVE+D
Sbjct: 421 PPRKGKKDDKAHPPIHPTAHAANLAG---DEKRVYEYITRRFLACCSKDALGWETTVEVD 477

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             GE F+A G  + E+NYL+V+ ++ W    +P +  G++F PT   L  G T  P LL+
Sbjct: 478 YGGEEFTATGLTVRERNYLNVFHYDKWADKELPNFEQGEEFVPTVCELREGKTSKPNLLT 537

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK--DASTRF-TPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+  HI+ ++DR Y  +    ST++  P+ LG  LV GYD I 
Sbjct: 538 EADLVTLMDKNGIGTDATIAQHIQTIVDRQYVIERMQGSTKYLVPSTLGIGLVEGYDAIG 597

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLH-----ARLNKVKLLE 301
               L KP+LR   E  M  + EGTK K+ +L  S+++ K  F       AR+  V ++ 
Sbjct: 598 FDRSLSKPQLRRETERRMVEICEGTKTKNDMLTESIEQYKDMFTRTQMEFARIVTVSVMP 657

Query: 302 AM--SIFFQRSNRSAGDELHATGE 323
           +M   +     ++  G+ L   G+
Sbjct: 658 SMPKHVTLIDHDQCVGNRLQGNGQ 681


>Q4PAW5_USTMA (tr|Q4PAW5) DNA topoisomerase OS=Ustilago maydis (strain 521 / FGSC
           9021) GN=UM02748.1 PE=3 SV=1
          Length = 1325

 Score =  249 bits (637), Expect = 1e-63,   Method: Compositional matrix adjust.
 Identities = 132/316 (41%), Positives = 189/316 (59%), Gaps = 15/316 (4%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L VAE LYQ GF+SYPRTETD +    +  +++ +Q     WG  AQRLLD   G + 
Sbjct: 425 RILDVAESLYQKGFLSYPRTETDEYDKDLDFTSLIAKQTADSAWGNVAQRLLD---GAFE 481

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++DKAHPPIHPT  ++G +G   + +++Y+ V R FLA     A+G +T+V I 
Sbjct: 482 RPRNGKNNDKAHPPIHPTSHASGLTG---DDKRVYDYVTRRFLASCWTDAIGNQTSVAIS 538

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE F A G VIL++NYL+V+ ++ W G+L+P +  G+ F PT L +  G T PP LL+
Sbjct: 539 IAGEKFHASGLVILQRNYLEVFTYDKWEGNLLPPFVRGETFRPTRLEMKEGATSPPKLLT 598

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK---DASTRFTPTNLGEALVMGYDDIE 246
           EADL+S MDK GIGTDAT+ DHI K+++R Y  +     +T   P+ LG  LV GY+ + 
Sbjct: 599 EADLVSLMDKNGIGTDATIADHIAKVVERRYVMQVKEGKTTYLVPSTLGIGLVEGYNQLN 658

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF--LHARLNKVKLLEAMS 304
           M   L KP LR   E  M  +  G + K   +A SLD+ +  F   H   +++    A +
Sbjct: 659 MEKSLSKPLLRRETEFRMSLICAGQRSKAETIAESLDEYRQVFALTHREFDRI----AAT 714

Query: 305 IFFQRSNRSAGDELHA 320
           +    ++ +AG E  A
Sbjct: 715 VVHYLTDPNAGQEARA 730


>I7LVW6_TETTS (tr|I7LVW6) DNA topoisomerase OS=Tetrahymena thermophila (strain
           SB210) GN=TTHERM_00216140 PE=3 SV=1
          Length = 1049

 Score =  249 bits (636), Expect = 2e-63,   Method: Compositional matrix adjust.
 Identities = 132/328 (40%), Positives = 190/328 (57%), Gaps = 10/328 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRT----NLHAIVQEQQGHPEWGIYAQRLLDPEA 65
           K +  AE+LYQ+G+ISYPRTET+ + P T     L  +V+ Q+   EWG Y+  L+D   
Sbjct: 312 KIMHTAEQLYQSGYISYPRTETNKY-PDTFQNGQLMDLVRNQKQSDEWGFYSSNLID--Q 368

Query: 66  GLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETT 125
           G ++ PR G  DDKAHPPIHP K  A ++       K+YE + RHFLA   K AVGA+T 
Sbjct: 369 GNFQRPRAGKQDDKAHPPIHPIKL-ANKNQLKPEEWKVYEFITRHFLASCGKDAVGAKTE 427

Query: 126 VEIDIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPP 185
           VE+    E F+  G V+ EKNYL+++ +E W  S++P    GQ   P  + L  G T PP
Sbjct: 428 VEVKFNDESFNIDGLVVKEKNYLEIWTYEKWNDSIVPPLQPGQVIIPQKILLQEGKTTPP 487

Query: 186 PLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI 245
             L+E++L+  M+K GIGTDATMHDHI  +  R YA K+    FTPT LG AL   YD  
Sbjct: 488 KPLTESELIDMMNKNGIGTDATMHDHILTIQKRGYAVKNQHLMFTPTPLGLALCHAYD-- 545

Query: 246 EMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSI 305
           ++   L KP+LR+ ME  M  V+EG   ++A++   +++MK+ +     NK   ++++  
Sbjct: 546 QLGLTLSKPDLRAKMERLMSDVAEGKTTREAIITQIMEEMKSIYKTVEQNKQLFIKSVGE 605

Query: 306 FFQRSNRSAGDELHATGEVVRRCGLCQE 333
             +    SA    ++  +    CG CQ+
Sbjct: 606 QLKEQENSASTLNNSNIQPGSECGKCQK 633


>M1WBC5_CLAPU (tr|M1WBC5) Related to DNA topoisomerase III OS=Claviceps purpurea
           20.1 GN=CPUR_04834 PE=3 SV=1
          Length = 689

 Score =  249 bits (635), Expect = 2e-63,   Method: Compositional matrix adjust.
 Identities = 139/341 (40%), Positives = 190/341 (55%), Gaps = 53/341 (15%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE LY  GFISYPRTETD F    NL A+VQ+Q     WG +AQ L++   G ++ P
Sbjct: 316 MTIAEGLYNKGFISYPRTETDRFDKGMNLKALVQKQTPDERWGQFAQGLVN---GAFKQP 372

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G HDDKAHPPIHP  ++A  S  S +  +LYE VVR FLAC S+ AVG+ TTV++   
Sbjct: 373 REGRHDDKAHPPIHPITYAA-PSVLSSDEGRLYEYVVRRFLACCSEDAVGSATTVDLQYG 431

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
            E+F+ACG ++LE+NYL+VY +E+W  +  +P +T G+ F PT   +  G T PP  L+E
Sbjct: 432 SEVFTACGVIVLERNYLEVYIYESWNNTKELPKFTRGETFQPTEALMTEGKTSPPSYLTE 491

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT---------------------------- 222
           ADL++ MD  GIGTDATM +HI+K+ DR YA                             
Sbjct: 492 ADLIALMDANGIGTDATMAEHIQKIQDREYAATINMGGQQAAGEVDETHTETQSARGGRG 551

Query: 223 ------------------KDASTR-FTPTNLGEALVMGYDDIEMAYKLWKPELRSAMESD 263
                             +   TR F PT LG AL++GYD +     L KP LR  ME  
Sbjct: 552 RGRGRGTGTRGASSTSGGRRGGTRVFVPTQLGVALILGYDRMNFETSLGKPFLRKEMELK 611

Query: 264 MKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMS 304
           MK++ EG   K  VL  S+ + +  F+  +  ++ +L A+S
Sbjct: 612 MKAICEGQTTKAVVLRESIGQYRQVFMQTQ-ERLDVLRAVS 651


>C1DZI4_MICSR (tr|C1DZI4) DNA topoisomerase (Fragment) OS=Micromonas sp. (strain
           RCC299 / NOUM17) GN=MICPUN_79030 PE=3 SV=1
          Length = 639

 Score =  248 bits (634), Expect = 3e-63,   Method: Compositional matrix adjust.
 Identities = 138/315 (43%), Positives = 186/315 (59%), Gaps = 22/315 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +K+AEELYQ GFISYPRTETD F    +    +++   HP++G +A  L     G +R
Sbjct: 329 QIMKLAEELYQAGFISYPRTETDKFPHDFDYRTSIEQLHPHPKFGFHAINL---SGGRFR 385

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGE--SGWSQNHRKL---YELVVRHFLACVSKPAVGAET 124
            P GGGHDDKAHPPI+PTK ++ +  + W   + +L   YE V RHFLA  S PAV  +T
Sbjct: 386 QPPGGGHDDKAHPPIYPTKLASTQDYASWRNRNSRLIDVYEFVCRHFLASCSLPAVAHKT 445

Query: 125 TVEIDIAGELFSACGRVILEKNYLDVY------------PFETWGGSLIPTYTVGQQFTP 172
           TVEID+ GE F A G +I E NYL+VY             ++ W  + IP+Y VGQ+F P
Sbjct: 446 TVEIDMGGERFKATGNMIKELNYLEVYGKGPAGGPVLQPSYDGWSSNTIPSYVVGQRFQP 505

Query: 173 TALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLL-DRFYATKDASTRFTP 231
           T L+L  G T+PPPLLSE DLLS M+   IGTDAT   HI+K++ +R YA K    R  P
Sbjct: 506 TELSLRPGRTQPPPLLSETDLLSKMEAHQIGTDATQAQHIEKVVGERGYARKVGDNRLMP 565

Query: 232 TNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLH 291
           T LGEAL  GY  + +A  +W P LR+  E+D   V+ G       L  ++      +  
Sbjct: 566 TELGEALCEGYARMGLA-GMWLPHLRAETEADTGRVARGEMNATVALRNAIGPAIDAYRG 624

Query: 292 ARLNKVKLLEAMSIF 306
              NK +L++A++ F
Sbjct: 625 LEANKQRLVDAVTEF 639


>Q4UB92_THEAN (tr|Q4UB92) DNA topoisomerase iii, putative OS=Theileria annulata
           GN=TA17755 PE=3 SV=1
          Length = 607

 Score =  248 bits (633), Expect = 3e-63,   Method: Compositional matrix adjust.
 Identities = 119/281 (42%), Positives = 175/281 (62%), Gaps = 3/281 (1%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +++AE LY  GFISYPRTET+ F    +L +I+ +    PE+  Y   LL+ +   + 
Sbjct: 298 KCMQLAEGLYNKGFISYPRTETNVFPSSIDLKSIIGKLSSVPEFSEYTNTLLNEDG--FH 355

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            P  G ++D+AHPPIHP      +   S+ H  LYE + R FLAC SK ++G ++ V ++
Sbjct: 356 EPTKGNNNDEAHPPIHPVNSLTRDRAESEEHWLLYEYITRRFLACCSKDSIGHQSNVILE 415

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           I+GELF+  G +I E+N+L++Y + TW   LIP ++  Q+  P  + L  G T+PP LLS
Sbjct: 416 ISGELFNLKGLIIQERNWLNIYKYTTWEAKLIPNFSENQEILPNEIILKDGATQPPDLLS 475

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIE-MA 248
           E++L+  M+K  IGTDATMH+HI+K+ DRFY  KD   RF PTNLG+A+  G+ +     
Sbjct: 476 ESNLIDLMNKNAIGTDATMHEHIQKIQDRFYCIKDDKLRFVPTNLGKAIYYGFKEYNYQN 535

Query: 249 YKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
             L KP LR+ ME DM  +S G K KD V+   ++ +++ F
Sbjct: 536 IDLTKPILRANMERDMSDISIGIKDKDQVVLNYVNLLRSIF 576


>A9V1D2_MONBE (tr|A9V1D2) DNA topoisomerase OS=Monosiga brevicollis GN=32733 PE=3
           SV=1
          Length = 1562

 Score =  248 bits (633), Expect = 3e-63,   Method: Compositional matrix adjust.
 Identities = 155/443 (34%), Positives = 227/443 (51%), Gaps = 49/443 (11%)

Query: 1   MFSVAYTLFKF-----LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGI 55
           M  +A   FK      L  AE+LYQ G +SYPRTET+ F    +L  +V+    H  +G 
Sbjct: 284 MQKIASRRFKIAPADSLSAAEKLYQQGILSYPRTETNKFDSSIDLRPMVEVFAQHSLYGA 343

Query: 56  YAQRLLDPEAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACV 115
           +A  LL+   G    PR G   D+AHPPIHPTK     SG  Q   ++Y+LV RHFLAC 
Sbjct: 344 FASSLLE---GQGPTPRNGNKSDEAHPPIHPTKSVNNLSGREQ---QIYDLVTRHFLACC 397

Query: 116 SKPAVGAETTVEIDIAGELFSACGRVILEKNYLDVY-PFETWGGS--------------- 159
           S+ A G ETTV +    E+F+A G VI ++ YL++Y P++ WGG                
Sbjct: 398 SRDARGEETTVTVHKGDEVFTAKGLVIRDRGYLEIYHPYDNWGGKVGFSKKIWPGQSFGY 457

Query: 160 ---------LIPTYTVGQQFTPTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHD 210
                    ++P YTVGQ+  P    +  G T  P LL+EADLLS M +  IGTDATM +
Sbjct: 458 MRQKEGDDGMLPPYTVGQEL-PANCEVLVGETSAPALLTEADLLSLMARYEIGTDATMAE 516

Query: 211 HIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSE 269
           HIK +L+R Y  K +A     PT LG ALV  YDD+     + +P+LR  ME+DM+ V  
Sbjct: 517 HIKNILEREYVCKQEAGQSLVPTTLGIALVNAYDDMSFEISVARPDLRREMEADMQRVCA 576

Query: 270 GTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGDELHATGEVVRRCG 329
           G + K  V+A  + + +  F        +   A   F  +   ++G     +GE  R C 
Sbjct: 577 GERSKAQVVARVISQYREVFQVVCREMDRFDNA---FVHQFGEASGAPPMVSGEAWRTCP 633

Query: 330 LCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQL 389
            C+++    K  +D  +++ C G+P+CR + WL    S + +  +    CT      +++
Sbjct: 634 ECKKAAQAFKTTKDKKWLLSCRGYPKCRASQWLDNCQSISVLDRH----CTRCHERLVRI 689

Query: 390 KFRQLEIPPNYNIN----HLGCI 408
           +FR   +P   +++    H GC+
Sbjct: 690 EFRAGALPAYLHVDGSSVHEGCL 712


>Q7Q111_ANOGA (tr|Q7Q111) DNA topoisomerase OS=Anopheles gambiae GN=AGAP010028
           PE=3 SV=3
          Length = 1025

 Score =  248 bits (633), Expect = 4e-63,   Method: Compositional matrix adjust.
 Identities = 158/436 (36%), Positives = 231/436 (52%), Gaps = 33/436 (7%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + + +AE+LY  G ISYPRTET+ F+    L  +VQ Q    +WG +A+++L  + G+  
Sbjct: 341 QVMTIAEKLYTQGIISYPRTETNMFTGDMKLAPLVQAQVASDQWGSFAEKVL--QWGV-- 396

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAET-TVEI 128
           NPR G   D+AHPPIHPTK     SG   +  ++YEL+ RHFLACVS+ A G+ET    +
Sbjct: 397 NPRNGKKSDQAHPPIHPTKLPTNLSG---DEWRVYELIARHFLACVSRDATGSETIVNVV 453

Query: 129 DIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLL 188
               E F+A G  I E+NYL+VYP++ W    I +Y VG  F PT L L  G T  P +L
Sbjct: 454 VAEEEEFTASGLCIHERNYLEVYPYDRWNAKEIHSYQVGHTFEPTELGLHEGSTTAPNML 513

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMA 248
           +EADL++ M+K GIGTDAT  +HI  + +R Y  +       P  LG  LV GY+ +E+ 
Sbjct: 514 TEADLIALMEKHGIGTDATHAEHINTIKERGYIGERDRGFLVPGTLGMGLVEGYEMMEL- 572

Query: 249 YKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQ 308
            +L  PELR+ +E+D+K V EG K  + VLA  + K K  +         L  AM    Q
Sbjct: 573 -RLAHPELRAGLEADLKLVCEGRKNPNDVLAEQIAKYKEVYRIMSQKARALDRAMG---Q 628

Query: 309 RSNRSAGD------------ELHATGEVVRRCGLCQESDMVLKKNRDGN-FMVGCLGFPQ 355
           R N++  +               A    V +C  C    M L+  RD + + +GC+ FP+
Sbjct: 629 RLNQTPQEPPPDAGASAATATGSAPMREVCKCPKCGHK-MCLRTKRDSSGYYLGCVAFPE 687

Query: 356 CRNAVWLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLE---IPPNYNINHLGCIGGCD 412
           CRN +W   S+ E  V  + C  C      ++ +KFR +    +  + +++       CD
Sbjct: 688 CRNNIWFDDSMREINVLDDTCARCGSK---KMTVKFRSVRFYALLQSTDMDEYQFCIVCD 744

Query: 413 EILRQLTEICGTGPRM 428
           +  R L  I  +  R+
Sbjct: 745 DKFRNLFNINESSVRV 760


>Q6C0R0_YARLI (tr|Q6C0R0) DNA topoisomerase OS=Yarrowia lipolytica (strain CLIB
           122 / E 150) GN=YALI0F22495g PE=3 SV=1
          Length = 620

 Score =  248 bits (632), Expect = 5e-63,   Method: Compositional matrix adjust.
 Identities = 139/305 (45%), Positives = 185/305 (60%), Gaps = 17/305 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           LK+AEELYQ  FISYPRTETD FS   +L  ++ +Q+  P WG YA  L+D +A  +  P
Sbjct: 315 LKLAEELYQQSFISYPRTETDQFSNDIDLMPLLAKQKNSPTWGDYASTLVDGDA--FSPP 372

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G H+DKAHPPIHP    A     S +H+++YEL+ RHF+AC SK A G ++ V++D  
Sbjct: 373 RWGRHNDKAHPPIHPIAHCANFK--SNDHKRVYELIARHFMACCSKDAKGQQSNVDVDWY 430

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGS--LIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           GE FSA G VILE N+LD+YP+  W GS  L     VG++       L  G T PP LL+
Sbjct: 431 GEQFSATGLVILETNFLDIYPYVKWTGSGELPAGLEVGKELPIVESMLAEGTTTPPSLLT 490

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTR----------FTPTNLGEAL 238
           E +LLS MD  GIGTDATM +HI  +++R Y  + +A  R          FTP+ LG+AL
Sbjct: 491 EPELLSLMDMNGIGTDATMAEHISTVVNREYILRCNAQGRPVQGRAKAEYFTPSPLGQAL 550

Query: 239 VMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVK 298
           V GYD I +   L KP +R  +ES +  V++G   KDAV+ ++L   K  F   +   VK
Sbjct: 551 VEGYDSIGLDRSLTKPFIRRDLESQLGQVAKGEASKDAVVESALIAFKDMFDLTKTEIVK 610

Query: 299 LLEAM 303
           L  A+
Sbjct: 611 LERAI 615


>A0DEK9_PARTE (tr|A0DEK9) Chromosome undetermined scaffold_48, whole genome
           shotgun sequence OS=Paramecium tetraurelia
           GN=GSPATT00016302001 PE=3 SV=1
          Length = 859

 Score =  247 bits (631), Expect = 5e-63,   Method: Compositional matrix adjust.
 Identities = 124/276 (44%), Positives = 167/276 (60%), Gaps = 7/276 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +++AE LY  G+ISYPRTET+ F P  NL  I+++QQ HP WG YA  LL+     + 
Sbjct: 318 KAMELAERLYNKGYISYPRTETNKFPPTINLQTIIRDQQNHPVWGEYATNLLN---FAFE 374

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            P+ G  DDKAHPPIHP K        ++    +Y+L+ RHFLAC SK A G+ETT+ + 
Sbjct: 375 YPKAGNKDDKAHPPIHPVKMMIENEAQNKQEWDVYQLITRHFLACCSKNAKGSETTITLQ 434

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           I  E FS  G VI EKNYL++Y +E W  S +P Y  G       LTL  G T PP  ++
Sbjct: 435 INDETFSKSGLVIKEKNYLEIYIYEEWSQSQVPNYQQGDSIK-IKLTLQKGSTSPPKPMT 493

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EA+L+  MDK GIGTDAT+H+HI  + DR YATK       PT +G ALV  Y+   + +
Sbjct: 494 EAELIGLMDKNGIGTDATIHEHINTIQDREYATKRGQI-IKPTKIGLALVESYEI--LGF 550

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKM 285
            L +P LR+ ME  M  V+ G K K  ++  ++++M
Sbjct: 551 TLHQPFLRAVMEQRMNEVALGKKEKSQIVQATINEM 586


>D0NZ98_PHYIT (tr|D0NZ98) DNA topoisomerase, putative OS=Phytophthora infestans
           (strain T30-4) GN=PITG_18634 PE=3 SV=1
          Length = 907

 Score =  247 bits (631), Expect = 6e-63,   Method: Compositional matrix adjust.
 Identities = 137/302 (45%), Positives = 183/302 (60%), Gaps = 10/302 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQR-LLDPEAGLWRN 70
           +K AE LY  G ISYPRTET  F   T+L ++V+  + H +WG Y  R LLD   G +  
Sbjct: 324 MKAAESLYNKGLISYPRTETSKFKEGTDLMSLVRAHETHQQWGNYVTRQLLD--GGKYEA 381

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G  DD+AHPPIHPTK     +    + +K+YE V  HFLAC S+ A G++T+V + +
Sbjct: 382 PRHGNSDDQAHPPIHPTKSVDLNTLPDPDEKKVYEFVSLHFLACCSRDAKGSQTSVVMAM 441

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
             E F A G ++ E+NYLD+Y +E W  S IP Y  G  F P+ L + SG T PPPLLSE
Sbjct: 442 LNERFIASGLMVEERNYLDIYKYEKWNASAIPVYKHGDVFRPSTLVMLSGDTNPPPLLSE 501

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK-DASTRFTPTNLGEALVMGYDDIEMAY 249
           ADL++ MD  GIGTDAT+ +HIK +L R YA K +  T+F PT LG ALV+ Y+   M  
Sbjct: 502 ADLIAKMDSNGIGTDATIAEHIKTILKREYAIKVNNETQFKPTTLGLALVLSYE--HMGL 559

Query: 250 KLWKPELRSA----MESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSI 305
           +L KP LR+A    ME+D K++S G K    V+ + + +MK  FL    +   L +  S 
Sbjct: 560 ELAKPVLRAAVSLIMENDCKAISLGQKALRQVVDSCMAQMKGIFLEVTRSATVLDQTFSE 619

Query: 306 FF 307
            F
Sbjct: 620 QF 621


>F1L3P3_ASCSU (tr|F1L3P3) DNA topoisomerase OS=Ascaris suum PE=2 SV=1
          Length = 469

 Score =  246 bits (628), Expect = 1e-62,   Method: Compositional matrix adjust.
 Identities = 134/293 (45%), Positives = 179/293 (61%), Gaps = 16/293 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + VAE+LY  GFISYPRTET+ F    +L+ ++++Q  + EWG +AQ +L+  A    NP
Sbjct: 7   MAVAEKLYSKGFISYPRTETNKFPSNLDLNPLIEQQVANAEWGEFAQEVLNRGA----NP 62

Query: 72  RGGGHDDKAHPPIHPTKFSAGES----GWSQNHRKLYELVVRHFLACVSKPAVGAETTVE 127
           R G   D+AHPPIHP KF+         WS     +YELVVRHFLACVS  A G ET V+
Sbjct: 63  RNGTKSDEAHPPIHPLKFALPSELVGYEWS-----IYELVVRHFLACVSIDARGQETKVQ 117

Query: 128 IDIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPL 187
           I +  E F+A G V+ E  YL VY +E WG   +P Y  G+     A+T+  G T+PPPL
Sbjct: 118 IKMGDESFTATGLVVEELGYLKVYKYEKWGDKTLPQYREGEVLHNCAVTMSEGHTQPPPL 177

Query: 188 LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEM 247
           LSEADL++ MDK GIGTDAT  +HI+ +  R YA  +A  RF P  LG ALV GYD   M
Sbjct: 178 LSEADLIALMDKYGIGTDATHAEHIETIKQRRYAALNAEKRFVPGYLGLALVDGYD--RM 235

Query: 248 AYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLL 300
            Y + KP +R+ +ES +K +  G + K+ VLA  + + +  F    + KV +L
Sbjct: 236 GYAMSKPHMRADLESQLKLICLGQRTKEEVLAEQIARYRRIFEQTEM-KVTML 287


>A0DS57_PARTE (tr|A0DS57) Chromosome undetermined scaffold_61, whole genome
           shotgun sequence OS=Paramecium tetraurelia
           GN=GSPATT00019578001 PE=3 SV=1
          Length = 895

 Score =  245 bits (625), Expect = 3e-62,   Method: Compositional matrix adjust.
 Identities = 120/299 (40%), Positives = 174/299 (58%), Gaps = 7/299 (2%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K + +AE+LY  G+ISYPRTET+ F P  NL  I+++Q  HP WG YAQ L+      + 
Sbjct: 318 KAMDLAEKLYNRGYISYPRTETNKFPPTINLQNIIRDQINHPVWGQYAQNLIHSN---FD 374

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  DDKAHPPIHP K  +     +     +Y+L+ RHFLAC SK A G+ETT+ + 
Sbjct: 375 QPRAGNKDDKAHPPIHPVKMMSESDAQTTQEWDIYQLITRHFLACCSKNAKGSETTINLQ 434

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           +  E F   G +I EKN+L++YP++ W  S +P Y +G       L + +G T PP  L+
Sbjct: 435 VKEESFYKQGLIITEKNFLEIYPYDEWSQSSVPKYNIG-DIIQINLKVQNGKTSPPKPLT 493

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAY 249
           EA+L+  MDK GIGTDAT+H+HI  + +R YA K       PT LG ALV  Y+   + +
Sbjct: 494 EAELIGMMDKNGIGTDATIHEHINTIQERDYAIKKGQI-IKPTKLGLALVESYE--VLGF 550

Query: 250 KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQ 308
            L KP LR+ ME  M  V++G K K+ ++  ++ +M       +  K  +++    + +
Sbjct: 551 TLHKPHLRALMEQRMNEVAQGVKQKNEIVEATIKEMSGILQELQQKKNLIIQTFGQYLE 609


>F4RET6_MELLP (tr|F4RET6) Putative uncharacterized protein (Fragment)
           OS=Melampsora larici-populina (strain 98AG31 / pathotype
           3-4-7) GN=MELLADRAFT_34533 PE=3 SV=1
          Length = 749

 Score =  245 bits (625), Expect = 3e-62,   Method: Compositional matrix adjust.
 Identities = 121/287 (42%), Positives = 185/287 (64%), Gaps = 8/287 (2%)

Query: 11  FLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRN 70
            L +AE+LY  G +SYPRTETD F P  +  A++++Q     WG +A RL +   G ++ 
Sbjct: 313 ILDIAEKLYIRGLVSYPRTETDQFDPAFDHQALIEKQINDASWGGFASRLKN--EGAFQL 370

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G  +DKAHPPIHPT   A  +  + + +++YEL+ R +LAC SK A+G  TT+++ I
Sbjct: 371 PRNGKKNDKAHPPIHPT---AHANDLASDEKRVYELITRRYLACCSKNAIGKTTTIDVLI 427

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
           A E F+A G VILE+NYL+VY ++ W G+ +P + VG++F P+   L+ G T  P LL+E
Sbjct: 428 AEEEFTATGLVILERNYLEVYIYDKWSGNTLPDFQVGEKFLPSVCELNEGTTTRPNLLTE 487

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYA--TKDASTRF-TPTNLGEALVMGYDDIEM 247
           ADL+  MDK GIGTDAT+ +HI +++DR Y   +++ + ++  P+ LG  LV GY+ I +
Sbjct: 488 ADLVGLMDKNGIGTDATIAEHIARIIDRSYVFKSREGNVQYLLPSTLGIGLVEGYNAIGL 547

Query: 248 AYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARL 294
              L KP+LR   E  M  + EG+K K  VL  ++++ +  F+ ++L
Sbjct: 548 DKSLSKPQLRRETEHRMSQICEGSKSKHEVLHQTIEEYREVFMRSKL 594


>Q5KAU9_CRYNJ (tr|Q5KAU9) DNA topoisomerase OS=Cryptococcus neoformans var.
           neoformans serotype D (strain JEC21 / ATCC MYA-565)
           GN=CNJ00400 PE=3 SV=1
          Length = 828

 Score =  244 bits (624), Expect = 4e-62,   Method: Compositional matrix adjust.
 Identities = 121/287 (42%), Positives = 173/287 (60%), Gaps = 15/287 (5%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L +AE+LYQ G +SYPRTETD + P+ + ++++Q+Q    +WG YAQ+          
Sbjct: 322 RILDLAEKLYQKGIVSYPRTETDQYDPKFDFNSLIQKQTLDNQWGAYAQK---------S 372

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT  +    G   + R+++EL+ R FLA  S  A G  TTVEI 
Sbjct: 373 KPRNGRKNDKAHPPIHPTAHAGNLEG---DERRVFELITRRFLASCSTNAEGQNTTVEIS 429

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IA E+FS  G V+L +NYL+VYP++ W    +P +  G+ F P  + L  G T  P LL+
Sbjct: 430 IADEIFSTTGLVVLRRNYLEVYPYDKWATHALPNFEEGEVFIPDVIDLKEGTTSRPSLLT 489

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR---FTPTNLGEALVMGYDDIE 246
           EADL+  MDK GIGTDAT+ +HI K+++R Y T+    R     P+ LG  LV G++ I 
Sbjct: 490 EADLVGLMDKNGIGTDATIAEHIAKIIERGYVTEKQEARIKYLVPSTLGIGLVEGFNAIG 549

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR 293
               L KP LR   E  M+ + +G +GK  +L T++++ K  F+ AR
Sbjct: 550 FDRSLSKPHLRRETEHRMQLICDGVRGKREILQTTIEEYKEVFVKAR 596


>B3L8C2_PLAKH (tr|B3L8C2) DNA topoisomerase III, putative OS=Plasmodium knowlesi
           (strain H) GN=PKH_120680 PE=3 SV=1
          Length = 661

 Score =  244 bits (624), Expect = 4e-62,   Method: Compositional matrix adjust.
 Identities = 129/314 (41%), Positives = 180/314 (57%), Gaps = 14/314 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE+LY  GFISYPRTET+SF    NL +IV E + +  +G YA +L   +   ++ P
Sbjct: 358 MNIAEKLYNKGFISYPRTETNSFPISMNLRSIVSELKKNNIFGSYANKLC--QGNNFKEP 415

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  +DKAHPPIHP K      G  +    +YE + RHFLA  S+ A+G  + V   I 
Sbjct: 416 RKGKLNDKAHPPIHPVKNMQKTDGVEEKEWIIYEFICRHFLAVCSEDAIGFNSKVVATIG 475

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F   G  I++KNYL++Y +E W    IP + V Q+F P +L ++ G+T+PP  LSE+
Sbjct: 476 KEEFFCKGLKIVKKNYLEIYIYEKWNNKNIPPFEVNQEFHPYSLLVEEGITQPPKYLSES 535

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI-EMAYK 250
           DLLS MDK GIGTDATMH+HI+ +  R Y  K++   F PTNLG ALV+ Y    ++   
Sbjct: 536 DLLSLMDKYGIGTDATMHEHIENIQKRNYVFKNSKNLFIPTNLGIALVLSYKKFKDIGID 595

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L  P LR+ ME DM  V+ GTK K+  +   +D MK  +     N++  L+    ++   
Sbjct: 596 LTDPSLRAKMEKDMTLVASGTKNKEETIRNYIDIMKYIY-QEMFNRIDFLDEQIKYY--- 651

Query: 311 NRSAGDELHATGEV 324
                  LH   EV
Sbjct: 652 -------LHNAAEV 658


>H6BXA1_EXODN (tr|H6BXA1) DNA topoisomerase OS=Exophiala dermatitidis (strain
           ATCC 34100 / CBS 525.76 / NIH/UT8656)
           GN=HMPREF1120_04295 PE=3 SV=1
          Length = 625

 Score =  244 bits (624), Expect = 4e-62,   Method: Compositional matrix adjust.
 Identities = 130/309 (42%), Positives = 181/309 (58%), Gaps = 13/309 (4%)

Query: 7   TLFKFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAG 66
           T  + + VAE+LY  GFISYPRTETD F        I++ Q     WG YAQ LLD   G
Sbjct: 314 TSHQVMSVAEKLYTKGFISYPRTETDQFPQGFGFQPIIERQTRDDRWGRYAQGLLD---G 370

Query: 67  LWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTV 126
            +R PR G H+D+AHPPIHP  ++A  S   Q+ +K+YE V R FLAC S+ A G  T +
Sbjct: 371 GFRTPRSGSHNDQAHPPIHPVNYAA-PSALDQHEKKVYEFVTRRFLACCSEDAKGEATDI 429

Query: 127 EIDIAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPP 185
           E+    E+F   G ++ E+NYLDVY ++ W  S  +P +TVG+ F PT   +  G T  P
Sbjct: 430 ELLWGTEMFHTHGLLVRERNYLDVYVYDKWESSQQLPIFTVGETFEPTEANMAEGKTTAP 489

Query: 186 PLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT--------KDASTRFTPTNLGEA 237
             L+E +L++ MD  GIGTDATM +HI K+ DR Y          +++   F PT LG A
Sbjct: 490 GYLTEPELITLMDANGIGTDATMAEHIAKIKDRSYVDTRPRSGGGRNSVQEFIPTTLGVA 549

Query: 238 LVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKV 297
           L+ GYD++ +   + KP LR  ME  MK++SEG K +  V+  SLD+ +  F+  +    
Sbjct: 550 LIEGYDNVGLDVSVSKPFLRKEMELKMKAISEGRKSRTEVVQESLDQYREVFIKTQREIN 609

Query: 298 KLLEAMSIF 306
            L EA++ +
Sbjct: 610 VLKEAVTKY 618


>A5K8A9_PLAVS (tr|A5K8A9) DNA topoisomerase III alpha, putative OS=Plasmodium
           vivax (strain Salvador I) GN=PVX_083255 PE=3 SV=1
          Length = 666

 Score =  244 bits (624), Expect = 4e-62,   Method: Compositional matrix adjust.
 Identities = 130/305 (42%), Positives = 177/305 (58%), Gaps = 4/305 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE+LY  GFISYPRTET+ F    NL +IV E +    +G YA++L   E   +R P
Sbjct: 363 MNIAEKLYNRGFISYPRTETNYFPSSMNLRSIVAELKKSKVFGSYAKKLC--EGNNFREP 420

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  +D+AHPPIHP K         +    +YEL+ RHFLA  S  A+G  + V   I 
Sbjct: 421 RKGRLNDQAHPPIHPVKNMHRTDKVEEREWAIYELICRHFLAVCSDDAIGFNSKVVATIG 480

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F   G  I++KNYL++Y +E W   ++P + V Q+F P +L +D G+T+PP  LSE 
Sbjct: 481 KEEFFCKGLKIVKKNYLEIYIYEKWNDKILPPFQVNQEFYPYSLLVDEGMTQPPKYLSEC 540

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI-EMAYK 250
           DLLS MDK GIGTDATMH+HI+ +  R Y  K+    F PTNLG ALV+ Y    ++   
Sbjct: 541 DLLSLMDKYGIGTDATMHEHIENIQKRNYVFKNKKNLFIPTNLGIALVLSYKKFKDIGVD 600

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRS 310
           L +P LR+ ME DM  V+ GTK KD  +   +D MK  +     N++ LL+     +  S
Sbjct: 601 LTEPSLRAKMEKDMTLVASGTKEKDETIRNYIDIMKYIYQEI-YNRIDLLDEQIKHYLNS 659

Query: 311 NRSAG 315
              AG
Sbjct: 660 AEGAG 664


>K6ULC5_9APIC (tr|K6ULC5) DNA topoisomerase III alpha OS=Plasmodium cynomolgi
           strain B GN=PCYB_121660 PE=3 SV=1
          Length = 646

 Score =  244 bits (623), Expect = 5e-62,   Method: Compositional matrix adjust.
 Identities = 126/297 (42%), Positives = 176/297 (59%), Gaps = 4/297 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE+LY  GFISYPRTET+ F    NL +IV E +    +G YA++L   E   ++ P
Sbjct: 343 MNIAEKLYNKGFISYPRTETNYFPSSMNLRSIVGELKKSKAFGSYAKKL--SEGNNFKEP 400

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  +D+AHPPIHP K         +    +YEL+ RHFLA  S  A+G  + V   I 
Sbjct: 401 RKGKLNDQAHPPIHPVKNMHKTDKVEEKEWIIYELICRHFLAVCSDDAIGFNSKVVATIG 460

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F   G  I++KNYL++Y +E W   +IP + V Q+F P +L ++ G+T+PP  LSE 
Sbjct: 461 KEEFFCKGLKIVKKNYLEIYIYEKWNDKIIPPFQVNQEFYPYSLLIEEGITQPPKYLSEC 520

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI-EMAYK 250
           DLLS MDK GIGTDATMH+HI+ +  R Y  K++   F PTNLG ALV+ Y    ++   
Sbjct: 521 DLLSLMDKYGIGTDATMHEHIENIQKRNYVFKNSKNLFVPTNLGIALVLSYKKFKDIGVD 580

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFF 307
           L +P LR+ ME DM  V+ GTK KD  +   +D MK  +     N++ LL+    ++
Sbjct: 581 LTEPSLRAKMEKDMTLVASGTKEKDETIRNYIDIMKYIYQEI-YNRIDLLDEQIKYY 636


>F9XBA1_MYCGM (tr|F9XBA1) DNA topoisomerase OS=Mycosphaerella graminicola (strain
           CBS 115943 / IPO323) GN=MYCGRDRAFT_71866 PE=3 SV=1
          Length = 636

 Score =  243 bits (621), Expect = 9e-62,   Method: Compositional matrix adjust.
 Identities = 128/309 (41%), Positives = 184/309 (59%), Gaps = 18/309 (5%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +++AE+LYQ GFISYPRTETD F   T+L+ I+ +Q   P+WG +AQ L +   G + 
Sbjct: 320 RVMQIAEKLYQDGFISYPRTETDQFDRNTDLNTIIDKQIQSPDWGNFAQGLRN---GGFS 376

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++DKAHPPIHP  F A  +     HR++YE +VR FLAC SK A G +T + I 
Sbjct: 377 WPRMGRNNDKAHPPIHPVNFVAN-NALDHEHRRVYEFIVRRFLACCSKDAQGTKTDIGIL 435

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E F+A G ++LE+NYLDVYP++ W  S  +P + VG+ F PT   +  G T PP  L
Sbjct: 436 YGAETFNASGLMVLERNYLDVYPYDKWTSSQELPIFAVGETFVPTEARMHEGETTPPGYL 495

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR------------FTPTNLGE 236
           +E +L+  MD  GIGTDATM +HI K+ +R Y       R            F PT LG 
Sbjct: 496 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVMARPRGRVQPQAGNGGVQEFIPTTLGV 555

Query: 237 ALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNK 296
           AL+ GY+ +     L KP LR  ME  MK++ EG K +  V+  ++++ +  ++  +  +
Sbjct: 556 ALIEGYESMGFEISLAKPFLRKEMELKMKAICEGRKTRRQVVEETIEQYRDVYMRTQ-RQ 614

Query: 297 VKLLEAMSI 305
           + LL A+S+
Sbjct: 615 LGLLRAVSL 623


>A7AMD4_BABBO (tr|A7AMD4) DNA topoisomerase family protein OS=Babesia bovis
           GN=BBOV_III001510 PE=3 SV=1
          Length = 633

 Score =  243 bits (620), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 125/281 (44%), Positives = 171/281 (60%), Gaps = 5/281 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  G++SYPRTET+ F    NL  +V     HP +G YA RLL  E      P
Sbjct: 325 MRLAESLYNKGYVSYPRTETNVFPSSMNLRDLVGMFSSHPLFGEYANRLLQGEII----P 380

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  +D+AHPPIHP K    E   S     LY  + R FLAC S  AVG E+ V +DI+
Sbjct: 381 RKGNKNDEAHPPIHPVKPLRREEAESPQSWDLYVYITRRFLACCSPAAVGDESIVFLDIS 440

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G V+ E+N+LD+YP+ +W G+ IP    GQ+  P+ + L  G TRPP LL+E 
Sbjct: 441 GEGFHAKGLVVRERNWLDIYPYASWNGTPIPAMEEGQELMPSRILLSDGCTRPPGLLTET 500

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDD-IEMAYK 250
           DL+  M+K GIGTDATMH+HI+K+ DR Y  K+++    PTNLG+AL   +         
Sbjct: 501 DLIDLMNKHGIGTDATMHEHIQKVQDRRYVKKESNFTLIPTNLGKALYNAFKSYAHQQID 560

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLH 291
           L KP LR+ MESD+ +++EG++ K  V+     +M+  +LH
Sbjct: 561 LTKPNLRALMESDICAIAEGSQDKGDVVNKYSQQMRQIYLH 601


>G7E0M5_MIXOS (tr|G7E0M5) Uncharacterized protein OS=Mixia osmundae (strain CBS
           9802 / IAM 14324 / JCM 22182 / KY 12970) GN=Mo03052 PE=3
           SV=1
          Length = 882

 Score =  243 bits (620), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 126/300 (42%), Positives = 177/300 (59%), Gaps = 10/300 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L++A+ LYQ G +SYPRTETD F P  N   ++++Q     WG +AQRL     G + 
Sbjct: 315 KVLEIADALYQRGILSYPRTETDQFDPHFNFQELIEKQTQDTRWGPFAQRL---HRGEFE 371

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PRGG  +D AHPPIHPT      +    +  ++YELV R FLAC  K A G +TTV + 
Sbjct: 372 RPRGGRKNDHAHPPIHPT----AHANLQGDEARVYELVTRRFLACCHKNATGRQTTVRVS 427

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IA E F+A G ++LE+NYLDVYP++ W G+ +P + + + F P    L  G T  P LL+
Sbjct: 428 IAREEFNASGLIVLERNYLDVYPYDRWEGNALPDFHLNETFLPATCELKEGKTTGPSLLT 487

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDA---STRFTPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+ +HI+ LL+R Y +++    ST   PT LG  LV GY+ + 
Sbjct: 488 EADLVNLMDKNGIGTDATIAEHIEHLLERDYISREKDGRSTVLVPTTLGIGLVEGYNRLG 547

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           +   L KP LR   E  M  +  G + +  V+  +LD+ +  F+ AR     L + +  F
Sbjct: 548 LDNSLSKPHLRRMTEHRMSLICTGQRTQQDVIEETLDEYREMFIVARRQWQTLTDTVREF 607


>I2G1E9_USTH4 (tr|I2G1E9) DNA topoisomerase OS=Ustilago hordei (strain Uh4875-4)
           GN=UHOR_04384 PE=3 SV=1
          Length = 986

 Score =  243 bits (620), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 130/321 (40%), Positives = 192/321 (59%), Gaps = 12/321 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L +AE LYQ GF+SYPRTETD +    + + ++ +Q     W   AQRLLD   G + 
Sbjct: 330 RILDIAESLYQKGFLSYPRTETDQYDKDFDFNTLIAKQTADGAWSGIAQRLLD---GAFE 386

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++DKAHPPIHPT  + G SG   + +++Y+ V R FLA     A+G++TTV ID
Sbjct: 387 RPRNGKNNDKAHPPIHPTAHAGGLSG---DDKRVYDYVTRRFLASCWSDAIGSQTTVAID 443

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE F A G VIL++NYL+V+ ++ W G+L+P +  G++ TPT L +  G T PP LL+
Sbjct: 444 IAGEKFHASGLVILQRNYLEVFTYDKWEGNLLPPFVRGERLTPTRLEMKQGCTSPPKLLT 503

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYA--TKDASTRF-TPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+ +HI K+++R Y    K+  T +  P+ LG  LV GY+ + 
Sbjct: 504 EADLVNLMDKNGIGTDATIAEHIAKVIERQYVMQVKEGKTNYLVPSTLGIGLVEGYNQLN 563

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           +   L KP LR   E  M  +  G + K   +  SL++ +  F        ++ + +  +
Sbjct: 564 LEKSLSKPLLRRETEYRMSLICAGQRTKTETIQESLEEYREVFALTSRQFGRIADTVLQY 623

Query: 307 FQRSNRSAGDELHATGEVVRR 327
              +N +AG E  A  E++ R
Sbjct: 624 L--TNPNAGQEARAV-ELIER 641


>C1GBF3_PARBD (tr|C1GBF3) DNA topoisomerase OS=Paracoccidioides brasiliensis
           (strain Pb18) GN=PADG_04954 PE=3 SV=1
          Length = 632

 Score =  243 bits (619), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 134/308 (43%), Positives = 183/308 (59%), Gaps = 19/308 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  +V++Q    +WG YAQRL+D   G + 
Sbjct: 317 KVMKIAEGLYTKGFISYPRTETDQFDKGIDLKKLVEKQISSEDWGQYAQRLMD---GAFT 373

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+D AHPPIHP  ++A  +  S++ R++YE V R FLAC S+ A G  T +EI 
Sbjct: 374 QPRAGRHNDNAHPPIHPVIYAAPAALSSEDERRVYEFVSRRFLACCSEDAKGESTEIEIK 433

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F A G ++LE+NYLDVY ++ W  S  +P +TVG+ F PT   +  G T  P  L
Sbjct: 434 YGDEIFHAHGLLVLERNYLDVYVYDKWESSQEMPVFTVGEVFEPTEAKITDGKTVAPGYL 493

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATKDAS---------TRFTPTNLGEAL 238
           +E +L+  MD  GIGTDATM +HI K+ +R Y AT+  S           F PT LG AL
Sbjct: 494 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVATRPRSGGGRGNNTVQEFIPTQLGVAL 553

Query: 239 VMGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARL 294
           V GYD++         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H + 
Sbjct: 554 VKGYDNVVNGLPDSPSLSKPFLRKEMELRMREICAGTKSKTEVVNESLHMYREVFIHTQ- 612

Query: 295 NKVKLLEA 302
            ++++L+A
Sbjct: 613 QRIEVLKA 620


>C5GXA3_AJEDR (tr|C5GXA3) DNA topoisomerase OS=Ajellomyces dermatitidis (strain
           ER-3 / ATCC MYA-2586) GN=BDCG_09090 PE=3 SV=1
          Length = 632

 Score =  243 bits (619), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 139/319 (43%), Positives = 185/319 (57%), Gaps = 21/319 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  +V++Q     WG YAQRL++   G + 
Sbjct: 319 KVMKIAEALYTKGFISYPRTETDQFDKGIDLKKLVEKQIPSENWGQYAQRLMN---GAFT 375

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  F+A  S  + + R +YE V R FLAC S+ A G  T VEI 
Sbjct: 376 QPRAGRHNDKAHPPIHPVIFAA-PSALNADERAVYEFVTRRFLACCSEDAKGESTEVEIK 434

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F   G ++LE+NYLDVY ++ W  S  IP +T+G+ F PT   L  G T  P  L
Sbjct: 435 YGDEMFHTNGLLVLERNYLDVYIYDKWESSQEIPPFTLGEAFEPTEAKLTDGKTVAPGYL 494

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATK--------DASTRFTPTNLGEALV 239
           +E +L+  MD  GIGTDATM +HI K+ +R Y AT+        ++   F PT+LG ALV
Sbjct: 495 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVATRPRGSGGGSNSVQEFIPTHLGVALV 554

Query: 240 MGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
            GYDD+         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H +  
Sbjct: 555 EGYDDVVNGLPDSPSLSKPFLRKEMEVRMREICAGTKTKTEVVNESLQMYREVFVHTQ-Q 613

Query: 296 KVKLLEAM--SIFFQRSNR 312
           ++ +L+A      F+  NR
Sbjct: 614 RIDVLKAACRKYIFEEGNR 632


>Q8IDM7_PLAF7 (tr|Q8IDM7) DNA topoisomerase III, putative OS=Plasmodium
           falciparum (isolate 3D7) GN=PF13_0251 PE=3 SV=1
          Length = 710

 Score =  243 bits (619), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 122/291 (41%), Positives = 173/291 (59%), Gaps = 4/291 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE+LY  G+ISYPRTET+ F    NLH I+ E + +  +G YA +L   E   ++ P
Sbjct: 407 MMLAEKLYNKGYISYPRTETNYFPDSMNLHKIINELRKNDNFGWYANKLC--EEHKYQKP 464

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G  +DKAHPPIHP K         +   KLYE + +HFLA  S  A+G  T V   I 
Sbjct: 465 RKGKMNDKAHPPIHPVKNMNKSLKVEEKEWKLYEFICKHFLAVCSNDAIGYNTKVTAKIQ 524

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F   G  I EKNYL++Y +E W   +IP++ V  +F PT+L ++ G+T+PP  LSE+
Sbjct: 525 EEQFFCKGLKIKEKNYLEIYTYEKWNDKIIPSFQVDDEFYPTSLLIEEGITQPPKYLSES 584

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDI-EMAYK 250
           +LL+ MDK  IGTDATMH+HI+ +  R Y  K++ + F PTNLG ALV  Y    ++   
Sbjct: 585 NLLTLMDKFSIGTDATMHEHIENIQKRNYVIKNSKSLFIPTNLGIALVQSYKKFKDIGID 644

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLE 301
           L  P LR+ ME DM  V+ G K K+ ++   +D MK  +     N++ +L+
Sbjct: 645 LTDPSLRAKMEKDMSLVASGVKQKNEIIRNYIDIMKYIY-QEIYNRIDVLD 694


>C0S9B3_PARBP (tr|C0S9B3) DNA topoisomerase OS=Paracoccidioides brasiliensis
           (strain Pb03) GN=PABG_04556 PE=3 SV=1
          Length = 710

 Score =  242 bits (618), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 134/308 (43%), Positives = 182/308 (59%), Gaps = 19/308 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  +V++Q     WG YAQRL+D   G + 
Sbjct: 312 KVMKIAEGLYTKGFISYPRTETDQFDKGIDLKKLVEKQISSENWGQYAQRLID---GAFT 368

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+D AHPPIHP  ++A  +  S++ R++YE V R FLAC S+ A G  T +EI 
Sbjct: 369 QPRAGRHNDNAHPPIHPVIYAAPAALSSEDERRVYEFVSRRFLACCSEDAKGESTEIEIK 428

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F A G ++LE+NYLDVY ++ W  S  +P +TVG+ F PT   +  G T  P  L
Sbjct: 429 YGDEIFHAHGLLVLERNYLDVYVYDKWESSQEMPVFTVGEVFEPTEAKITDGKTVAPGYL 488

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATKDAS---------TRFTPTNLGEAL 238
           +E +L+  MD  GIGTDATM +HI K+ +R Y AT+  S           F PT LG AL
Sbjct: 489 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVATRPRSGGGRGNNTVQEFIPTQLGVAL 548

Query: 239 VMGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARL 294
           V GYD++         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H + 
Sbjct: 549 VKGYDNVVNGLPDSPSLSKPFLRKEMELRMREICAGTKSKTEVVNESLHMYREVFIHTQ- 607

Query: 295 NKVKLLEA 302
            ++++L+A
Sbjct: 608 QRIEVLKA 615


>F2TP38_AJEDA (tr|F2TP38) DNA topoisomerase OS=Ajellomyces dermatitidis (strain
           ATCC 18188 / CBS 674.68) GN=BDDG_07946 PE=3 SV=1
          Length = 630

 Score =  242 bits (618), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 139/319 (43%), Positives = 185/319 (57%), Gaps = 21/319 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  +V++Q     WG YAQRL++   G + 
Sbjct: 317 KVMKIAEALYTKGFISYPRTETDQFDKGIDLKKLVEKQIPSENWGQYAQRLMN---GAFT 373

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  F+A  S  + + R +YE V R FLAC S+ A G  T VEI 
Sbjct: 374 QPRAGRHNDKAHPPIHPVIFAA-PSALNADERAVYEFVTRRFLACCSEDAKGESTEVEIK 432

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F   G ++LE+NYLDVY ++ W  S  IP +T+G+ F PT   L  G T  P  L
Sbjct: 433 YGDEMFHTNGLLVLERNYLDVYIYDKWESSQEIPPFTLGEAFEPTEAKLTDGKTVAPGYL 492

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATK--------DASTRFTPTNLGEALV 239
           +E +L+  MD  GIGTDATM +HI K+ +R Y AT+        ++   F PT+LG ALV
Sbjct: 493 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVATRPRGSGGGSNSVQEFIPTHLGVALV 552

Query: 240 MGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
            GYDD+         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H +  
Sbjct: 553 EGYDDVVNGLPDSPSLSKPFLRKEMEVRMREICAGTKTKTEVVNESLQMYREVFVHTQ-Q 611

Query: 296 KVKLLEAM--SIFFQRSNR 312
           ++ +L+A      F+  NR
Sbjct: 612 RIDVLKAACRKYIFEEGNR 630


>C5JDG2_AJEDS (tr|C5JDG2) DNA topoisomerase OS=Ajellomyces dermatitidis (strain
           SLH14081) GN=BDBG_00396 PE=3 SV=1
          Length = 632

 Score =  242 bits (617), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 139/319 (43%), Positives = 185/319 (57%), Gaps = 21/319 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  +V++Q     WG YAQRL++   G + 
Sbjct: 319 KVMKIAEALYTKGFISYPRTETDQFDKGIDLKKLVEKQIPSENWGQYAQRLMN---GAFI 375

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  F+A  S  + + R +YE V R FLAC S+ A G  T VEI 
Sbjct: 376 QPRAGRHNDKAHPPIHPVIFAA-PSALNADERAVYEFVTRRFLACCSEDAKGESTEVEIK 434

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F   G ++LE+NYLDVY ++ W  S  IP +T+G+ F PT   L  G T  P  L
Sbjct: 435 YGDEMFHTNGLLVLERNYLDVYIYDKWESSQEIPPFTLGEAFEPTEAKLTDGKTVAPGYL 494

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATK--------DASTRFTPTNLGEALV 239
           +E +L+  MD  GIGTDATM +HI K+ +R Y AT+        ++   F PT+LG ALV
Sbjct: 495 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVATRPRGSGGGSNSVQEFIPTHLGVALV 554

Query: 240 MGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
            GYDD+         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H +  
Sbjct: 555 EGYDDVVNGLPDSPSLSKPFLRKEMEVRMREICAGTKTKTEVVNESLQMYREVFVHTQ-Q 613

Query: 296 KVKLLEAM--SIFFQRSNR 312
           ++ +L+A      F+  NR
Sbjct: 614 RIDVLKAACRKYIFEEGNR 632


>A4RUT1_OSTLU (tr|A4RUT1) Predicted protein (Fragment) OS=Ostreococcus
           lucimarinus (strain CCE9901) GN=OSTLU_33842 PE=3 SV=1
          Length = 641

 Score =  242 bits (617), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 136/299 (45%), Positives = 179/299 (59%), Gaps = 24/299 (8%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + +K+AE+LY  GFISYPRTETD F    +    ++E   HP++G Y +RL     G +R
Sbjct: 330 QIMKIAEDLYNDGFISYPRTETDKFPNDFDYDGTLREMHQHPQFGFYVERLT--TGGQFR 387

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQ----NHR--KLYELVVRHFLACVSKPAVGAE 123
            P GG  DDKAHPPI+PTK  A ++ ++Q    NH   K+YE V RHFLA  S PAV  +
Sbjct: 388 RPPGGTKDDKAHPPIYPTKL-ATDAQYAQMRNKNHNAPKVYEFVCRHFLATCSYPAVALK 446

Query: 124 TTVEIDIAGELFSACGRVILEKNYLDVY------------PFETWGGSLIPTYTVGQQFT 171
           T V++DIAGE F A G +I E+NYLD+Y             ++ WG S +P YT G+QF 
Sbjct: 447 THVDVDIAGETFRATGVMIRERNYLDIYGPGPPEGPRLAPTYDNWGNSTLPVYTPGEQFV 506

Query: 172 PTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLL-DRFYATKDASTRFT 230
           PT L L  G TRPP  LSE DLLS M+   IGTDAT   HI+K++ +R YA K    R  
Sbjct: 507 PT-LNLHEGSTRPPDYLSEVDLLSLMESHMIGTDATQAQHIEKVVGERGYARKVGDNRLM 565

Query: 231 PTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
           PT LGEALV+ YD + +A  +W P  R+ ME+D+ +V+      +A L   L  M   +
Sbjct: 566 PTELGEALVLAYDRMGVA-DMWLPTKRAKMEADVDAVAHNRMDPNAGLRLHLQTMLQAY 623


>B4DSJ0_HUMAN (tr|B4DSJ0) DNA topoisomerase 3-alpha OS=Homo sapiens GN=TOP3A PE=2
           SV=1
          Length = 531

 Score =  242 bits (617), Expect = 3e-61,   Method: Compositional matrix adjust.
 Identities = 120/283 (42%), Positives = 175/283 (61%), Gaps = 5/283 (1%)

Query: 141 VILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEADLLSCMDKE 200
           +IL +NYLDVYP++ W   ++P Y  G  F P+ + +  G T PP LL+EADL++ M+K 
Sbjct: 1   MILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKH 60

Query: 201 GIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKLWKPELRSAM 260
           GIGTDAT  +HI+ +  R Y       RF P +LG  LV GYD   M Y++ KP+LR+ +
Sbjct: 61  GIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYD--SMGYEMSKPDLRAEL 118

Query: 261 ESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQRSNRSAGDE--L 318
           E+D+K + +G K K  VL   + K K  F+ A     KL EA++ +F      A  E   
Sbjct: 119 EADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIY 178

Query: 319 HATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAVWLPGSVSEAAVTTNPCNF 378
            A  E +R+C  C + DMVLK  ++G F + C+GFP+CR+AVWLP SV EA+  ++ C  
Sbjct: 179 PAMPEPIRKCPQCNK-DMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPV 237

Query: 379 CTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTEI 421
           C P PVYR++LKF++  +PP   +  + CIGGCD+ LR++ ++
Sbjct: 238 CQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDL 280


>E7A0Y6_SPORE (tr|E7A0Y6) DNA topoisomerase OS=Sporisorium reilianum (strain
           SRZ2) GN=sr13804 PE=3 SV=1
          Length = 998

 Score =  241 bits (616), Expect = 3e-61,   Method: Compositional matrix adjust.
 Identities = 131/314 (41%), Positives = 187/314 (59%), Gaps = 11/314 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L VAE LYQ GF+SYPRTETD +    +  +++ +Q     WG  AQRLLD   G + 
Sbjct: 330 RILDVAESLYQKGFLSYPRTETDQYDKDFDFTSLIAKQTADGAWGNIAQRLLD---GDFE 386

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++DKAHPPIHPT  + G +G   + +++Y+ V R FLA   K A+G +TTV I 
Sbjct: 387 RPRNGKNNDKAHPPIHPTSHANGLTG---DDKRVYDYVTRRFLASCWKDAIGTQTTVSIS 443

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE F A G VIL++NYL+V+ ++ W G+L+P +  G+ F PT   +  G T PP LL+
Sbjct: 444 IAGERFHASGLVILQRNYLEVFTYDKWEGNLLPPFVRGETFRPTRFEMKEGSTSPPKLLT 503

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK---DASTRFTPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+ +HI K+++R Y  +     +T   P+ LG  LV GY+ + 
Sbjct: 504 EADLVNLMDKNGIGTDATIAEHIAKVIERRYVMQVKEGKTTYLVPSTLGIGLVEGYNQLN 563

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           +   L KP LR   E  M  +  G + K   +A SL++ +  F  A  N+     A ++ 
Sbjct: 564 LEKSLSKPLLRRETEFRMSLICAGQRSKAETIAESLEEYREVF--ALTNREFDRIATTVV 621

Query: 307 FQRSNRSAGDELHA 320
              ++ SAG E  A
Sbjct: 622 QYLTDPSAGQEARA 635


>G4TIC8_PIRID (tr|G4TIC8) Related to DNA topoisomerase III alpha
           OS=Piriformospora indica (strain DSM 11827)
           GN=PIIN_05011 PE=3 SV=1
          Length = 632

 Score =  241 bits (616), Expect = 3e-61,   Method: Compositional matrix adjust.
 Identities = 128/319 (40%), Positives = 188/319 (58%), Gaps = 11/319 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L  A+ LYQ G +SYPRTETD +  + +    +Q+Q   PEWG +A RL     G + 
Sbjct: 288 QILDTADALYQRGILSYPRTETDQYDDQFDFGQYIQKQTSSPEWGAFATRL---RQGEFS 344

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G  +DKAHPPIHPT ++   +G   N +K+YE V R FLA  SK A G +TT+ + 
Sbjct: 345 KPRKGKKNDKAHPPIHPTAYAGNLAG---NEKKVYEYVTRRFLASCSKDAEGFQTTITVA 401

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           + GE FSA G ++LE+NYL+V+P++ W    +P +  G++F PT   L  G T  P LL+
Sbjct: 402 VNGEEFSASGLLVLERNYLEVFPYDKWSSHELPPFEEGEEFMPTICELREGETTRPSLLT 461

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK--DASTRF-TPTNLGEALVMGYDDIE 246
           EADL+S MDK GIGTDAT+  HI  +++R Y  +  + +T++  P+ LG  LV GY+ I 
Sbjct: 462 EADLVSLMDKNGIGTDATIAQHINTIVEREYVMERLEGNTKYLVPSTLGVGLVHGYNQIG 521

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHAR--LNKVKLLEAMS 304
           +   L KP+LR   E  M  V +  K KD +L  S+++ K  F+ AR   N +   +  S
Sbjct: 522 LEKSLSKPQLRRETERSMVQVCDRIKTKDDMLQESIEQYKEVFILARREFNLIINKDQAS 581

Query: 305 IFFQRSNRSAGDELHATGE 323
           +   ++ ++  DE+    E
Sbjct: 582 LKVHKALKTVADEVEGMVE 600


>M9MAK8_9BASI (tr|M9MAK8) DNA topoisomerase III alpha OS=Pseudozyma antarctica T-34
            GN=PANT_5c00028 PE=4 SV=1
          Length = 1780

 Score =  241 bits (614), Expect = 5e-61,   Method: Compositional matrix adjust.
 Identities = 127/315 (40%), Positives = 186/315 (59%), Gaps = 11/315 (3%)

Query: 10   KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
            + L +AE LYQ GF+SYPRTETD F    + +A++ +Q     WG  AQRLLD   G + 
Sbjct: 1135 RILDIAESLYQKGFLSYPRTETDQFDKEFDFNALIAKQTADGAWGGVAQRLLD---GAFE 1191

Query: 70   NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
             PR G ++DKAHPPIHPT  ++  +G   + +++Y+ V R FL      A+G +TTV + 
Sbjct: 1192 RPRNGRNNDKAHPPIHPTSHASNLTG---DDKRVYDYVTRRFLGSCWTDAIGTQTTVNVS 1248

Query: 130  IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
            +AGE F A G VIL++NYL+V+ ++ W G+L+P +  G+ FTPT L +  G T  P LL+
Sbjct: 1249 VAGEKFHASGLVILQRNYLEVFTYDKWDGNLLPPFVRGETFTPTRLEMKQGATTAPKLLT 1308

Query: 190  EADLLSCMDKEGIGTDATMHDHIKKLLDRFY--ATKDASTRF-TPTNLGEALVMGYDDIE 246
            EADL+S MDK GIGTDAT+ +HI K+++R Y  + K+  T +  P+ LG  LV GY+ + 
Sbjct: 1309 EADLVSLMDKNGIGTDATIAEHIAKVIERQYVMSVKEGKTSYLVPSTLGVGLVEGYNQLN 1368

Query: 247  MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
            +   L KP LR   E  M  +  G + K   +A S+++ +  F        ++ E +  +
Sbjct: 1369 LEKSLCKPVLRRETEFRMSLICAGERTKAETIAESVNEYREVFALTNRQFGRIAETVLSY 1428

Query: 307  FQRSNRSAGDELHAT 321
                N  AG E  A 
Sbjct: 1429 LTDPN--AGQEARAV 1441


>G0NRK3_CAEBE (tr|G0NRK3) DNA topoisomerase OS=Caenorhabditis brenneri
           GN=Cbn-top-3 PE=3 SV=1
          Length = 763

 Score =  240 bits (613), Expect = 7e-61,   Method: Compositional matrix adjust.
 Identities = 132/298 (44%), Positives = 180/298 (60%), Gaps = 11/298 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           ++VAE+LY  G+ISYPRTET+ F    +L  +VQ+Q     WG +A  +L  + G+  NP
Sbjct: 320 MQVAEKLYSKGYISYPRTETNKFPAGLDLRPLVQQQTNSGIWGDFANEVL--QNGI--NP 375

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHP  F    +    +  K+YELVVRHFLACVS+ A G ET V + I 
Sbjct: 376 RNGRKSDEAHPPIHPLSF-VDRTQLQGDDWKVYELVVRHFLACVSQDAQGEETMVNLRIG 434

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F + G  I +  YL VY +E WG  L+PTY  G++F+   L +  G T+PP LL+EA
Sbjct: 435 GEKFHSSGLRIRDMGYLKVYIYERWGNRLLPTYVEGERFSDYNLRIGDGKTQPPELLTEA 494

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDK GIGTDAT  +HI+K+  R Y       +  P+ LG ALV GYDD  M + +
Sbjct: 495 DLIALMDKFGIGTDATHAEHIEKIKTREYIGVKPDGKLIPSFLGLALVDGYDD--MGFAM 552

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
            KP+LR+ +E  +K + EG + K  VL   + K KA F+ +  N    +E +S   QR
Sbjct: 553 SKPDLRANLEIGLKEICEGRRQKQQVLDEQIGKYKAIFVESERN----IEVLSQSLQR 606


>C1H2W6_PARBA (tr|C1H2W6) DNA topoisomerase OS=Paracoccidioides brasiliensis
           (strain ATCC MYA-826 / Pb01) GN=PAAG_05109 PE=3 SV=1
          Length = 632

 Score =  240 bits (613), Expect = 7e-61,   Method: Compositional matrix adjust.
 Identities = 135/308 (43%), Positives = 181/308 (58%), Gaps = 19/308 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  +V++Q     WG  AQRL+D   G + 
Sbjct: 317 KVMKIAEGLYTKGFISYPRTETDQFDKGIDLKKLVEKQIPSENWGQNAQRLMD---GAFT 373

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  ++A  +  S++ R++YE V R FLAC S+ A G  T +EI 
Sbjct: 374 QPRAGRHNDKAHPPIHPVIYAAPAALSSEDERRVYEFVSRRFLACCSEDAKGESTEIEIK 433

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F A G ++LE+NYLDVY ++ W  S  +P +TVG+ F PT   +  G T  P  L
Sbjct: 434 YGDEIFHAHGLLVLERNYLDVYVYDKWESSQEMPIFTVGEVFEPTEAKITDGKTVAPGYL 493

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATKDAS---------TRFTPTNLGEAL 238
           +E +L+  MD  GIGTDATM +HI K+ +R Y AT+  S           F PT LG AL
Sbjct: 494 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVATRPRSGGGRGNNTVQEFIPTQLGVAL 553

Query: 239 VMGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARL 294
           V GYDD+         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H + 
Sbjct: 554 VKGYDDVVNGLPDSPSLSKPFLRKEMELRMREICAGTKSKTEVVNESLHMYREVFIHTQ- 612

Query: 295 NKVKLLEA 302
            +++ L+A
Sbjct: 613 QRIEALKA 620


>B9Q815_TOXGO (tr|B9Q815) DNA topoisomerase OS=Toxoplasma gondii GN=TGVEG_067560
           PE=3 SV=1
          Length = 291

 Score =  240 bits (612), Expect = 1e-60,   Method: Compositional matrix adjust.
 Identities = 118/227 (51%), Positives = 152/227 (66%), Gaps = 4/227 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           + +AE LYQ G ISYPRTET+ FSP  +L ++++   G   WG YAQ+L+D +  LW  P
Sbjct: 47  MSIAESLYQRGIISYPRTETEVFSPTMDLLSLIRVHIGSTAWGTYAQKLVDGDF-LW--P 103

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             G  DDKAHPPIHP K     S   +   KLYE V RHFLAC S+ A G ET VEIDIA
Sbjct: 104 SDGARDDKAHPPIHPLKL-MQRSELEEEEWKLYEFVTRHFLACCSEDAFGFETRVEIDIA 162

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GE F A G  +LE+ +LDVYP+E W G+ +P + V ++  P+++ +    T PPPLL+EA
Sbjct: 163 GEGFYATGLTVLERRWLDVYPYEQWSGNRLPRFLVNERVMPSSILMSERQTEPPPLLTEA 222

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEAL 238
           DL+  MDK GIGTDATMHDHI+ + DR Y  K+ + +F PT+LG AL
Sbjct: 223 DLIDLMDKNGIGTDATMHDHIRTIQDRHYCYKNENMQFVPTDLGVAL 269


>G6DDL0_DANPL (tr|G6DDL0) DNA topoisomerase OS=Danaus plexippus GN=KGM_05417 PE=3
           SV=1
          Length = 734

 Score =  239 bits (610), Expect = 1e-60,   Method: Compositional matrix adjust.
 Identities = 125/289 (43%), Positives = 174/289 (60%), Gaps = 10/289 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +K+AE+LY  G ISYPRTET+ FS   NL  +++  +  P WG +AQ +L        NP
Sbjct: 317 MKIAEKLYTAGIISYPRTETNQFSNDINLVKLIELHKDDPSWGTFAQNVLSQGP----NP 372

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHPTK+    +      R++YE +VR FLAC SK AVG ETTV + +A
Sbjct: 373 RRGNKSDQAHPPIHPTKYV---TNLVNMERRVYEFIVRTFLACCSKDAVGKETTVRLTVA 429

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F A G ++ E+NYLDVYP++ W    I  Y VG  FT T + +    T PP LL+EA
Sbjct: 430 DEGFHASGLIVTERNYLDVYPYDKWTSKHIHDYQVGDTFTATKVEMIESETSPPELLTEA 489

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           +L++ M+K GIGTDAT  DHI+ +  R Y   + + +F PT LG  LV GYD + +   +
Sbjct: 490 NLITLMEKHGIGTDATHADHIETIKIRNYVVIEGN-KFKPTELGRGLVEGYDMLSLP--M 546

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLL 300
            KP LR+  E+D+K + +  K  DAVL   +++ K  +    L + KL+
Sbjct: 547 SKPHLRANFEADLKLICDRKKSADAVLRDQIEEYKKLYDKMLLEQNKLI 595


>K8F3E9_9CHLO (tr|K8F3E9) DNA topoisomerase OS=Bathycoccus prasinos
           GN=Bathy09g04290 PE=3 SV=1
          Length = 751

 Score =  239 bits (610), Expect = 2e-60,   Method: Compositional matrix adjust.
 Identities = 130/319 (40%), Positives = 186/319 (58%), Gaps = 22/319 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +KVAEELYQ GFISYPRTETD F    N    +     H  +G YA+ L++ +   +R
Sbjct: 403 KIMKVAEELYQKGFISYPRTETDRFPDSFNFLENIALFYNHDTFGPYARELVERDG--FR 460

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGE--SGWSQNHRKLYELVVRHFLACVSKPAVGAETTVE 127
            P GG  DDKAHPPI+P K +     +GW + ++++Y+ V+RHFLA  SKPAVG +TTVE
Sbjct: 461 KPPGGHRDDKAHPPIYPAKLATAHEYNGWKRENQQVYDFVLRHFLATCSKPAVGYKTTVE 520

Query: 128 IDIAGELFSACGRVILEKNYLDVYP---------------FETW-GGSLIPTYTVGQQFT 171
           +D AGE F A G +I ++ YL +Y                F+ W     +PT+  G++F 
Sbjct: 521 VDCAGEGFKANGLMIADRAYLRIYGPGPIFPPDGPRLNPYFDNWTAQEELPTFEDGERFQ 580

Query: 172 PTALTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLL-DRFYATKDASTRFT 230
           P+   L    T  P +LSE DLL+ M+K GIGTDAT   HI K++ +R YA K    R  
Sbjct: 581 PSHRNLRDSETVKPQMLSEVDLLTLMEKNGIGTDATQAQHIDKVVGERGYAKKVGENRLV 640

Query: 231 PTNLGEALVMGYDDIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFL 290
           PTN+GEALV GYD +++ + +W+P  R+ ME D+ +V  G+  K+  +  +++ M   F 
Sbjct: 641 PTNIGEALVAGYDSLQLGF-MWQPTKRAEMEKDVDNVHRGSITKEDAIRKNIEPMLRAFA 699

Query: 291 HARLNKVKLLEAMSIFFQR 309
               N+  L+  +  F +R
Sbjct: 700 KCESNEQDLIRIVKRFVER 718


>Q4MYZ9_THEPA (tr|Q4MYZ9) DNA topoisomerase III, putative OS=Theileria parva
           GN=TP03_0692 PE=3 SV=1
          Length = 531

 Score =  239 bits (610), Expect = 2e-60,   Method: Compositional matrix adjust.
 Identities = 115/279 (41%), Positives = 172/279 (61%), Gaps = 12/279 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           +++AE LY  G+ISYPRTET++F    NL +I+      PE+  Y   LL+   G ++ P
Sbjct: 233 MQLAESLYNKGYISYPRTETNAFPSSINLKSIIHNLSSVPEFSQYTHNLLN--EGGFKEP 290

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
             G ++D+AHPPIHP      +   S+ H  LYE + R FLAC SK A+G ++ + ++I+
Sbjct: 291 TKGKNNDEAHPPIHPVNSLTRDRAESEQHWLLYEYITRRFLACCSKDAIGHQSNIILEIS 350

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
           GELF+  G VI E+N+L++Y + +W G ++P +   Q+          G TRPP LLSE+
Sbjct: 351 GELFNLKGLVIKERNWLNIYKYSSWEGKIVPEFQENQE---------DGATRPPDLLSES 401

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEM-AYK 250
           +L+  M+K GIGTDATMH+HI+K+ DR Y  KD   RF PTNLG+A+  G+ +       
Sbjct: 402 NLIDLMNKNGIGTDATMHEHIQKIQDRHYCVKDDKLRFVPTNLGKAIYYGFKEYNYHNID 461

Query: 251 LWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF 289
           L KP LR+ ME DM  +S G K K+ V+   ++ +++ +
Sbjct: 462 LTKPSLRANMEKDMSDISVGIKRKEQVVLNYVNLLRSIY 500


>K4BYJ3_SOLLC (tr|K4BYJ3) DNA topoisomerase OS=Solanum lycopersicum
           GN=Solyc05g014740.1 PE=3 SV=1
          Length = 296

 Score =  238 bits (608), Expect = 3e-60,   Method: Compositional matrix adjust.
 Identities = 106/129 (82%), Positives = 118/129 (91%)

Query: 41  HAIVQEQQGHPEWGIYAQRLLDPEAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNH 100
           H +VQEQ+GHP WG YAQRLLDP++GLWRNP GGGHDDKAHPPIHPTKFSAGE+ WSQ+H
Sbjct: 165 HTMVQEQEGHPVWGTYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDH 224

Query: 101 RKLYELVVRHFLACVSKPAVGAETTVEIDIAGELFSACGRVILEKNYLDVYPFETWGGSL 160
            ++YELVVRHFLACVS+PAVGAET VEIDIAGE FSACGRVIL KNYLDVY FE+WGGS+
Sbjct: 225 HRVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSV 284

Query: 161 IPTYTVGQQ 169
           IPTY+ GQQ
Sbjct: 285 IPTYSFGQQ 293


>F0XZ97_AURAN (tr|F0XZ97) DNA topoisomerase (Fragment) OS=Aureococcus
           anophagefferens GN=AURANDRAFT_20044 PE=3 SV=1
          Length = 627

 Score =  238 bits (608), Expect = 3e-60,   Method: Compositional matrix adjust.
 Identities = 137/300 (45%), Positives = 182/300 (60%), Gaps = 13/300 (4%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLD--PE---AG 66
           ++VAE LYQ G++SYPRTET+ F    ++  +V  Q+    +G +A +LLD  P+   A 
Sbjct: 330 MEVAEALYQRGYVSYPRTETELFRDTCDVRELVDRQRPDGRFGTFAAQLLDLPPDDRRAF 389

Query: 67  LWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTV 126
           LW  PR G  DD+AHPPIHPTK  A          K++EL+ RHFLAC ++ A G +T  
Sbjct: 390 LW--PRQGAKDDEAHPPIHPTKAVAANE-LQGKEAKVFELIARHFLACCARDARGRQTNA 446

Query: 127 EIDIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQF-TPTALTLDSGVTRPP 185
              + GE F A G ++ E+NYLDVYP+E+W  + +P +  G     P+AL L    T+PP
Sbjct: 447 TAQLGGERFDARGLMVDERNYLDVYPYESWSTATLPPFFAGDALPRPSALNLARSRTQPP 506

Query: 186 PLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR--FTPTNLGEALVMGYD 243
             L+EADLLS MD  GIGTDATM DHIK +L R YA +D +    F PT LG ALV  YD
Sbjct: 507 RGLTEADLLSKMDAHGIGTDATMADHIKTVLTRDYALRDNAPPHVFRPTPLGSALVEAYD 566

Query: 244 DIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAM 303
            + M   L  P+LR+A+E+D+  V+ G K KDAVLA  L  M+  F     +  KL +AM
Sbjct: 567 AMGMRLNL--PQLRAALEADVALVASGAKSKDAVLADCLRTMRDSFDAVSRDVAKLDDAM 624


>A8XHL1_CAEBR (tr|A8XHL1) DNA topoisomerase OS=Caenorhabditis briggsae GN=top-3
           PE=3 SV=2
          Length = 774

 Score =  238 bits (607), Expect = 4e-60,   Method: Compositional matrix adjust.
 Identities = 130/298 (43%), Positives = 181/298 (60%), Gaps = 11/298 (3%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
           ++VAE+LY  GFISYPRTET+ F P  NL  +V++Q     WG +A  +L  + G+   P
Sbjct: 334 MQVAEKLYSKGFISYPRTETNKFPPGLNLTPLVEQQVQSTTWGDFATEVL--QKGV--TP 389

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G   D+AHPPIHP  F A ++    +  K+YELVVRHFLACVS+ A G ET V + + 
Sbjct: 390 RNGHKSDEAHPPIHPLTF-ADKNTLHGDDWKVYELVVRHFLACVSQDAQGEETMVNLRVG 448

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLSEA 191
            E F + G  I +  YL VY +E WG  L+PTY  G++F+   L +  G T+PP LL+EA
Sbjct: 449 SEKFHSSGLRIRDMGYLKVYVYEKWGNRLLPTYNQGERFSDYKLKIGDGKTQPPDLLTEA 508

Query: 192 DLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYDDIEMAYKL 251
           DL++ MDK GIGTDAT  +HI+K+  R Y       +  P+ LG ALV GYDD  M + +
Sbjct: 509 DLIALMDKFGIGTDATHAEHIEKIKTREYIGVKPDGKLIPSFLGLALVDGYDD--MGFAM 566

Query: 252 WKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIFFQR 309
            KP+LR+ +E  +K + +G + K  VL   + K K+ F+ +  N    +E +S   QR
Sbjct: 567 SKPDLRANLEMGLKDICDGRRQKQEVLDEQIGKYKSIFVESERN----IEVLSQSLQR 620


>R9NXV4_9BASI (tr|R9NXV4) Uncharacterized protein OS=Pseudozyma hubeiensis SY62
           GN=PHSY_001006 PE=4 SV=1
          Length = 992

 Score =  238 bits (607), Expect = 4e-60,   Method: Compositional matrix adjust.
 Identities = 128/314 (40%), Positives = 186/314 (59%), Gaps = 11/314 (3%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           + L VAE LYQ GF+SYPRTETD +    +  +++ +Q     WG  AQRLLD   G + 
Sbjct: 330 RILDVAESLYQKGFLSYPRTETDQYDKDFDFTSLIAKQTADGAWGNVAQRLLD---GAFE 386

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G ++DKAHPPIHPT  + G +G   + +++YE V R FLA     A+G +T+V I 
Sbjct: 387 RPRNGKNNDKAHPPIHPTSHANGLTG---DDKRVYEYVTRRFLASCWTDAIGNQTSVAIV 443

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
           IAGE F A G VIL++NYL+V+ ++ W G+L+P +  G+ F PT   +  G T PP LL+
Sbjct: 444 IAGEKFHASGLVILQRNYLEVFTYDKWEGNLLPPFVRGETFRPTRFEMKEGATSPPKLLT 503

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK---DASTRFTPTNLGEALVMGYDDIE 246
           EADL++ MDK GIGTDAT+ +HI K+++R Y  +     +T   P+ LG  LV GY+ + 
Sbjct: 504 EADLVNLMDKNGIGTDATIAEHIAKVVERRYVMQVKEGKTTYLVPSTLGIGLVEGYNQLN 563

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
           +   L KP LR   E  M  +  G + K   +A S+++ +  F  A  N+     A ++ 
Sbjct: 564 LEKSLSKPLLRRETEFRMSLICAGQRSKAETMAESIEEYRQVF--ALTNRQFDRIAATVL 621

Query: 307 FQRSNRSAGDELHA 320
              ++ +AG E  A
Sbjct: 622 QYLTDPNAGQEARA 635


>A6R6R2_AJECN (tr|A6R6R2) DNA topoisomerase OS=Ajellomyces capsulata (strain NAm1
           / WU24) GN=HCAG_05320 PE=3 SV=1
          Length = 632

 Score =  238 bits (606), Expect = 5e-60,   Method: Compositional matrix adjust.
 Identities = 135/307 (43%), Positives = 180/307 (58%), Gaps = 19/307 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  ++++Q     WG YAQRL++   G + 
Sbjct: 319 KVMKIAETLYTKGFISYPRTETDQFDKGIDLKKLIEKQIPSENWGQYAQRLIN---GSFT 375

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  F+A  +  S + R +YE V R FLAC S+ A G  T VEI 
Sbjct: 376 QPRAGHHNDKAHPPIHPVIFAA-PTVLSNDERLVYEFVTRRFLACCSEDAKGESTEVEIK 434

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F   G ++LE+NYLDVY ++ W  S  IP +T+G+ F PT   +  G T  P  L
Sbjct: 435 YGDEIFHTHGLLVLERNYLDVYVYDKWESSQEIPPFTLGEVFEPTEAKITDGKTVAPGYL 494

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATK--------DASTRFTPTNLGEALV 239
           +E +L+  MD  GIGTDATM DHI K+ +R Y AT+        +A   F PT LG ALV
Sbjct: 495 TEPELIGLMDANGIGTDATMADHIAKIKEREYVATRPRGGGRGNNAVQEFIPTQLGVALV 554

Query: 240 MGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
            GYD++         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H +  
Sbjct: 555 EGYDNVVNGLPDSPSLSKPFLRKEMELRMREICVGTKSKTEVVNESLQMYREVFVHTQ-Q 613

Query: 296 KVKLLEA 302
           ++ +L+A
Sbjct: 614 RIDMLKA 620


>B6HC62_PENCW (tr|B6HC62) DNA topoisomerase OS=Penicillium chrysogenum (strain
           ATCC 28089 / DSM 1075 / Wisconsin 54-1255) GN=Pc18g05420
           PE=3 SV=1
          Length = 628

 Score =  237 bits (605), Expect = 6e-60,   Method: Compositional matrix adjust.
 Identities = 130/302 (43%), Positives = 172/302 (56%), Gaps = 18/302 (5%)

Query: 11  FLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRN 70
            +KVAE LY  GFISYPRTETD F    +L  +V++Q     WG YA+ L+D   G +R 
Sbjct: 318 IMKVAEALYTKGFISYPRTETDQFDKGIDLKKLVEKQYPDNSWGQYARELID---GKFRT 374

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G H+DKAHPPIHP  +    +  + N +K+YE VVR FLAC S  A G  T +EI  
Sbjct: 375 PRSGRHNDKAHPPIHPVSW-VSPNQLNANEKKVYEFVVRRFLACCSDDAKGQSTEIEIQY 433

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             E F   G ++LE+NYLDVY ++ W  S  +P +  G+ F PT   +  G T PP  L+
Sbjct: 434 GDEFFHTNGLIVLERNYLDVYVYDKWESSQQLPNFERGELFEPTEANIFDGKTTPPNYLT 493

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT-------KDASTRFTPTNLGEALVMGY 242
           E +L+  MD  GIGTDATM +HI K+ +R Y         + +   F PT LG ALV GY
Sbjct: 494 EPELIGLMDANGIGTDATMAEHIAKIKEREYVAINQRGGGRSSVQEFIPTRLGVALVEGY 553

Query: 243 DDI----EMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHA--RLNK 296
           D++      +  L KP LR  ME  M  +  GTK +  V+  SLD  +  F+H   R+N 
Sbjct: 554 DNVVEGLPNSVSLSKPFLRKEMELRMVEICSGTKTRQEVVQQSLDMYREVFIHTQRRINM 613

Query: 297 VK 298
           +K
Sbjct: 614 LK 615


>E4YMV5_OIKDI (tr|E4YMV5) DNA topoisomerase OS=Oikopleura dioica
           GN=GSOID_T00029850001 PE=3 SV=1
          Length = 929

 Score =  237 bits (604), Expect = 7e-60,   Method: Compositional matrix adjust.
 Identities = 149/421 (35%), Positives = 224/421 (53%), Gaps = 17/421 (4%)

Query: 4   VAYTLFKFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDP 63
           +  T  + + VAE+LY  G+ISYPRTET+ F    +L  +V+ QQ    +  +A  +L  
Sbjct: 305 LGLTAKEIMSVAEKLYLKGYISYPRTETNIFPKSLDLRPMVEAQQRDNRFTTFASDIL-- 362

Query: 64  EAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAE 123
           + GL  NPR G   D+AHPPIHP K  AG  G      K++E + R FLAC+S+ A G E
Sbjct: 363 QNGL--NPRNGKKTDEAHPPIHPLKEGAGLVG---PEAKVHEFISRRFLACLSRDATGFE 417

Query: 124 TTVEIDIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTR 183
           TT +I++A E F+A G +I ++ YL++YP++ W    +P+Y   ++F  T   L    T 
Sbjct: 418 TTCKIEVAEEEFTAKGLLISDRGYLEIYPYDKWSDKTLPSYRFNEEFMITNAELCESSTS 477

Query: 184 PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYD 243
            P  LSE DL+  MDK GIGTDAT  DHI  +  R Y +     RF P++LG  LV  Y+
Sbjct: 478 APLYLSEPDLIGLMDKYGIGTDATHADHIATIQSRGYISLTREKRFIPSSLGIGLVTAYE 537

Query: 244 DIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF--LHARLNKVKLLE 301
           D+ +   L    LRS +E D+  +  G K +  VL T +   +  +      LN+   + 
Sbjct: 538 DLSIP--LANHLLRSGLEKDLVRIENGEKTRAEVLRTQITAYREAYKKTEENLNRFSDVI 595

Query: 302 AMSIF-FQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAV 360
           A S+    R++       +A    V RC  CQ   MV+K   +G+  V C G+P+C+ + 
Sbjct: 596 AESLGDIPRNDEPFELPRNAADTSVARCPRCQ-CPMVVKTIPNGSVCVSCTGYPECKTSG 654

Query: 361 WLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTE 420
           +LP          + CN C+ G  Y+++  F    +P +    + GC+ GCD+ L+Q+  
Sbjct: 655 FLPRG-GRMVTRMHSCN-CSDG-FYKVKWNFESGSVPGHMTGEYEGCL-GCDDDLKQVIR 710

Query: 421 I 421
           I
Sbjct: 711 I 711


>E4YXQ0_OIKDI (tr|E4YXQ0) DNA topoisomerase OS=Oikopleura dioica
           GN=GSOID_T00022213001 PE=3 SV=1
          Length = 914

 Score =  237 bits (604), Expect = 8e-60,   Method: Compositional matrix adjust.
 Identities = 149/421 (35%), Positives = 224/421 (53%), Gaps = 17/421 (4%)

Query: 4   VAYTLFKFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDP 63
           +  T  + + VAE+LY  G+ISYPRTET+ F    +L  +V+ QQ    +  +A  +L  
Sbjct: 305 LGLTAKEIMSVAEKLYLKGYISYPRTETNIFPKSLDLRPMVEAQQRDNRFTTFASDIL-- 362

Query: 64  EAGLWRNPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAE 123
           + GL  NPR G   D+AHPPIHP K  AG  G      K++E + R FLAC+S+ A G E
Sbjct: 363 QNGL--NPRNGKKTDEAHPPIHPLKEGAGLVG---PEAKVHEFISRRFLACLSRDATGFE 417

Query: 124 TTVEIDIAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTR 183
           TT +I++A E F+A G +I ++ YL++YP++ W    +P+Y   ++F  T   L    T 
Sbjct: 418 TTCKIEVAEEEFTAKGLLISDRGYLEIYPYDKWSDKTLPSYRFNEEFMITNAELCESSTS 477

Query: 184 PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTRFTPTNLGEALVMGYD 243
            P  LSE DL+  MDK GIGTDAT  DHI  +  R Y +     RF P++LG  LV  Y+
Sbjct: 478 APLYLSEPDLIGLMDKYGIGTDATHADHIATIQSRGYISLTREKRFIPSSLGIGLVTAYE 537

Query: 244 DIEMAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACF--LHARLNKVKLLE 301
           D+ +   L    LRS +E D+  +  G K +  VL T +   +  +      LN+   + 
Sbjct: 538 DLSIP--LANHLLRSGLEKDLVRIENGEKTRAEVLRTQITAYREAYKKTEENLNRFSDVI 595

Query: 302 AMSIF-FQRSNRSAGDELHATGEVVRRCGLCQESDMVLKKNRDGNFMVGCLGFPQCRNAV 360
           A S+    R++       +A    V RC  CQ   MV+K   +G+  V C G+P+C+ + 
Sbjct: 596 AESLGDIPRNDEPFELPRNAADTSVARCPRCQ-CPMVVKTIPNGSVCVSCTGYPECKTSG 654

Query: 361 WLPGSVSEAAVTTNPCNFCTPGPVYRIQLKFRQLEIPPNYNINHLGCIGGCDEILRQLTE 420
           +LP          + CN C+ G  Y+++  F    +P +    + GC+ GCD+ L+Q+  
Sbjct: 655 FLPRG-GRMVTRMHSCN-CSDG-FYKVKWNFESGSVPGHMTGEYEGCL-GCDDDLKQVIR 710

Query: 421 I 421
           I
Sbjct: 711 I 711


>Q751B3_ASHGO (tr|Q751B3) DNA topoisomerase OS=Ashbya gossypii (strain ATCC 10895
           / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=AGL101C PE=3
           SV=1
          Length = 631

 Score =  236 bits (603), Expect = 1e-59,   Method: Compositional matrix adjust.
 Identities = 119/274 (43%), Positives = 173/274 (63%), Gaps = 5/274 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPE-AGLWRN 70
           L  AE+LYQ GFISYPRTETD FS + NL  +VQ+Q  H +WG YA +LL  E +  ++ 
Sbjct: 328 LDAAEKLYQKGFISYPRTETDVFSKQANLQGLVQQQTEHSQWGAYASKLLSGEGSNRFQW 387

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G HDD+AHPPIHP   +  ++  S + +++YE VVRHFLAC S+ A G  + +++  
Sbjct: 388 PREGKHDDQAHPPIHPVLCAQPDANLSVDEKRVYEYVVRHFLACCSQDAKGRSSKIKLKW 447

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             E FSA G  + E+N+L++Y ++ W  S  +PT  +  Q       + SG T PP  ++
Sbjct: 448 HTEEFSATGLQVHEENFLEIYTYQKWTSSEQLPTLPLNSQVEFAKAEMKSGKTSPPKYIT 507

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR---FTPTNLGEALVMGYDDIE 246
           E++L+  MD  GIGTDAT+ +HI+K+ +R Y   + + +   F PT LG +LV G++DI 
Sbjct: 508 ESELIMLMDANGIGTDATIAEHIEKIQERQYIKAEGTAKNKVFKPTMLGRSLVHGFEDIG 567

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLAT 280
           +     KP LR  ME D+K + EGTK +++VLA 
Sbjct: 568 LEESFAKPFLRRDMELDLKRICEGTKDRNSVLAN 601


>M9N124_ASHGS (tr|M9N124) FAGL101Cp OS=Ashbya gossypii FDAG1 GN=FAGOS_FAGL101C
           PE=4 SV=1
          Length = 631

 Score =  236 bits (603), Expect = 1e-59,   Method: Compositional matrix adjust.
 Identities = 119/274 (43%), Positives = 173/274 (63%), Gaps = 5/274 (1%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPE-AGLWRN 70
           L  AE+LYQ GFISYPRTETD FS + NL  +VQ+Q  H +WG YA +LL  E +  ++ 
Sbjct: 328 LDAAEKLYQKGFISYPRTETDVFSKQANLQGLVQQQTEHSQWGAYASKLLSGEGSNRFQW 387

Query: 71  PRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDI 130
           PR G HDD+AHPPIHP   +  ++  S + +++YE VVRHFLAC S+ A G  + +++  
Sbjct: 388 PREGKHDDQAHPPIHPVLCAQPDANLSVDEKRVYEYVVRHFLACCSQDAKGRSSKIKLKW 447

Query: 131 AGELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             E FSA G  + E+N+L++Y ++ W  S  +PT  +  Q       + SG T PP  ++
Sbjct: 448 HTEEFSATGLQVHEENFLEIYTYQKWTSSEQLPTLPLNSQVEFAKAEMKSGKTSPPKYIT 507

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDASTR---FTPTNLGEALVMGYDDIE 246
           E++L+  MD  GIGTDAT+ +HI+K+ +R Y   + + +   F PT LG +LV G++DI 
Sbjct: 508 ESELIMLMDANGIGTDATIAEHIEKIQERQYIKAEGTAKNKVFKPTMLGRSLVHGFEDIG 567

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLAT 280
           +     KP LR  ME D+K + EGTK +++VLA 
Sbjct: 568 LEESFAKPFLRRDMELDLKRICEGTKDRNSVLAN 601


>Q0CHD1_ASPTN (tr|Q0CHD1) DNA topoisomerase OS=Aspergillus terreus (strain NIH
           2624 / FGSC A1156) GN=ATEG_06911 PE=3 SV=1
          Length = 588

 Score =  236 bits (603), Expect = 1e-59,   Method: Compositional matrix adjust.
 Identities = 131/301 (43%), Positives = 178/301 (59%), Gaps = 18/301 (5%)

Query: 12  LKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWRNP 71
            +VAE LY  GFISYPRTETD F    +L  +V++Q     WG YA+ LLD   G +R P
Sbjct: 280 FQVAEALYTKGFISYPRTETDQFDKGIDLKKLVEKQLPDSNWGQYARGLLD---GGFRTP 336

Query: 72  RGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEIDIA 131
           R G H+D+AHPPIHP  +    S  S + +K+YE VVR FLAC S+ A G  T VEI+  
Sbjct: 337 RAGRHNDRAHPPIHPICW-VSPSTLSADEKKVYEFVVRRFLACCSEDAKGQSTEVEIEYG 395

Query: 132 GELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPPLLSE 190
            E+F A G ++LE+NYLDVY ++ W  S  +P + +G+ F PT   +  G T PP  L+E
Sbjct: 396 DEMFHAKGLIVLERNYLDVYVYDKWESSQTLPPFQMGETFEPTEAKIFDGKTTPPNYLTE 455

Query: 191 ADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT-------KDASTRFTPTNLGEALVMGYD 243
            +L+  MD  GIGTDATM +HI K+  R Y         ++A     PT LG ALV GYD
Sbjct: 456 PELIGLMDANGIGTDATMAEHIAKVKTRQYVAVHSRGSGRNAVKELIPTRLGIALVEGYD 515

Query: 244 DIEM----AYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHA--RLNKV 297
           ++      +  L KP LR  ME+ M+ +  G+K +  V+  SL+K +  F+H   R+N +
Sbjct: 516 NVVAGLSDSISLSKPFLRKEMEARMREICAGSKTRQQVVHESLEKYREVFIHTQRRINIL 575

Query: 298 K 298
           K
Sbjct: 576 K 576


>C0NGZ5_AJECG (tr|C0NGZ5) DNA topoisomerase OS=Ajellomyces capsulata (strain
           G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) GN=HCBG_02617
           PE=3 SV=1
          Length = 630

 Score =  236 bits (602), Expect = 1e-59,   Method: Compositional matrix adjust.
 Identities = 134/307 (43%), Positives = 180/307 (58%), Gaps = 19/307 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  ++++Q     WG YAQRL++   G + 
Sbjct: 317 KVMKIAETLYTKGFISYPRTETDQFDKGIDLKKLIEKQIPSENWGQYAQRLIN---GSFT 373

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  F+A  +  S + R +YE V R FLAC S+ A G  T VEI 
Sbjct: 374 QPRAGHHNDKAHPPIHPVIFAA-PTVLSNDERLVYEFVTRRFLACCSEDAKGESTEVEIK 432

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F   G ++LE+NYLDVY ++ W  S  IP +T+G+ F PT   +  G T  P  L
Sbjct: 433 YGDEIFHTHGLLVLERNYLDVYVYDKWESSQEIPPFTLGEVFEPTEAKIMDGKTVAPGYL 492

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATK--------DASTRFTPTNLGEALV 239
           +E +L+  MD  GIGTDATM DHI ++ +R Y AT+        +A   F PT LG ALV
Sbjct: 493 TEPELIGLMDANGIGTDATMADHIARIKEREYVATRPRGGGRGNNAVQEFIPTQLGVALV 552

Query: 240 MGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
            GYD++         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H +  
Sbjct: 553 EGYDNVVNGLPDSPSLSKPFLRKEMELRMREICVGTKSKTEVVNESLQMYREVFVHTQ-Q 611

Query: 296 KVKLLEA 302
           ++ +L+A
Sbjct: 612 RIDILKA 618


>C6H6Z0_AJECH (tr|C6H6Z0) DNA topoisomerase OS=Ajellomyces capsulata (strain
           H143) GN=HCDG_02191 PE=3 SV=1
          Length = 630

 Score =  236 bits (602), Expect = 1e-59,   Method: Compositional matrix adjust.
 Identities = 134/307 (43%), Positives = 180/307 (58%), Gaps = 19/307 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +K+AE LY  GFISYPRTETD F    +L  ++++Q     WG YAQRL++   G + 
Sbjct: 317 KVMKIAETLYTKGFISYPRTETDQFDKGIDLKKLIEKQIPSENWGQYAQRLIN---GSFT 373

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+DKAHPPIHP  F+A  +  S + R +YE V R FLAC S+ A G  T VEI 
Sbjct: 374 QPRAGHHNDKAHPPIHPVIFAA-PTVLSNDERLVYEFVTRRFLACCSEDAKGESTEVEIK 432

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSL-IPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F   G ++LE+NYLDVY ++ W  S  IP +T+G+ F PT   +  G T  P  L
Sbjct: 433 YGDEIFHTHGLLVLERNYLDVYVYDKWESSQEIPPFTLGEVFEPTEAKITDGKTVAPGYL 492

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFY-ATK--------DASTRFTPTNLGEALV 239
           +E +L+  MD  GIGTDATM DHI ++ +R Y AT+        +A   F PT LG ALV
Sbjct: 493 TEPELIGLMDANGIGTDATMADHIARIKEREYVATRPRGGGRGNNAVQEFIPTQLGVALV 552

Query: 240 MGYDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLN 295
            GYD++         L KP LR  ME  M+ +  GTK K  V+  SL   +  F+H +  
Sbjct: 553 EGYDNVVNGLPDSPSLSKPFLRKEMELRMREICVGTKSKMEVVNESLQMYREVFVHTQ-Q 611

Query: 296 KVKLLEA 302
           ++ +L+A
Sbjct: 612 RIDILKA 618


>B8PK31_POSPM (tr|B8PK31) DNA topoisomerase OS=Postia placenta (strain ATCC 44394
           / Madison 698-R) GN=POSPLDRAFT_88435 PE=3 SV=1
          Length = 707

 Score =  236 bits (601), Expect = 2e-59,   Method: Compositional matrix adjust.
 Identities = 122/306 (39%), Positives = 179/306 (58%), Gaps = 19/306 (6%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K L +AE LYQ GF+SYPRTETD F P+ +   ++Q+Q   P WG +A            
Sbjct: 308 KILDIAEHLYQQGFLSYPRTETDRFDPQFDFMTLLQKQTVDPAWGPFAHM---------- 357

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
               G  DDKAHPPIHPT ++   +G   + +++YE + R FLAC SK A+G +TTV+++
Sbjct: 358 ---QGKKDDKAHPPIHPTAYAGNLAG---DEKRVYEYITRRFLACCSKDALGWQTTVDVE 411

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGSLIPTYTVGQQFTPTALTLDSGVTRPPPLLS 189
             GE F A G  + E+NYL+V+P++ W    +P +T G+QF PT   L  G T  P LL+
Sbjct: 412 YGGEEFYATGLTVRERNYLEVFPYDKWSDKELPHFTQGEQFVPTVCELREGQTTRPALLT 471

Query: 190 EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATK--DASTRF-TPTNLGEALVMGYDDIE 246
           E+DL+S MDK GIGTDAT+  HI+ ++DR Y  +    ST++  P+ LG  LV GYD + 
Sbjct: 472 ESDLVSMMDKNGIGTDATIAQHIQTIIDRNYVIERMQGSTKYLVPSTLGIGLVEGYDAMG 531

Query: 247 MAYKLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHARLNKVKLLEAMSIF 306
               L +P+LR   E  M  + EGT+ K  +L  S+++ K  ++  +    +L+  +   
Sbjct: 532 FERSLSRPQLRRETERRMVEICEGTRTKADMLTESVEQYKEIYMRTKQEFERLVNCVGQR 591

Query: 307 FQRSNR 312
            Q + R
Sbjct: 592 LQGNGR 597


>Q2UEI0_ASPOR (tr|Q2UEI0) DNA topoisomerase OS=Aspergillus oryzae (strain ATCC
           42149 / RIB 40) GN=AO090026000611 PE=3 SV=1
          Length = 629

 Score =  235 bits (600), Expect = 2e-59,   Method: Compositional matrix adjust.
 Identities = 129/303 (42%), Positives = 177/303 (58%), Gaps = 18/303 (5%)

Query: 10  KFLKVAEELYQTGFISYPRTETDSFSPRTNLHAIVQEQQGHPEWGIYAQRLLDPEAGLWR 69
           K +KVAE LY  GFISYPRTETD F    +L  ++++Q     WG YA+ LLD   G +R
Sbjct: 318 KIMKVAEALYTKGFISYPRTETDQFDKGIDLKKLIEKQFPDTNWGQYARGLLD---GGYR 374

Query: 70  NPRGGGHDDKAHPPIHPTKFSAGESGWSQNHRKLYELVVRHFLACVSKPAVGAETTVEID 129
            PR G H+D+AHPPIHP  +    +  S + +K+YE VVR FLAC S+ A G  + VEI 
Sbjct: 375 TPRAGRHNDQAHPPIHPICW-VSPTALSADEKKVYEFVVRRFLACCSEDAKGQTSEVEIQ 433

Query: 130 IAGELFSACGRVILEKNYLDVYPFETWGGS-LIPTYTVGQQFTPTALTLDSGVTRPPPLL 188
              E+F A G ++LE+NYLDVY ++ W  S  +P + +G+ F PT   +  G T PP  L
Sbjct: 434 YGDEMFHAKGLIVLERNYLDVYVYDKWESSQQLPNFQMGELFEPTEAKIFDGKTTPPNYL 493

Query: 189 SEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAT-------KDASTRFTPTNLGEALVMG 241
           +E +L+  MD  GIGTDATM +HI K+ +R Y         ++A     PT LG ALV G
Sbjct: 494 TEPELIGLMDANGIGTDATMAEHIAKIKEREYVAVHSRGSGRNAVKELIPTRLGVALVEG 553

Query: 242 YDDIEMAY----KLWKPELRSAMESDMKSVSEGTKGKDAVLATSLDKMKACFLHA--RLN 295
           YD++         L KP LR  ME  M+ +  G+K +  V+  SL+  +  F+H   R+N
Sbjct: 554 YDNVVTGLPDSPSLSKPFLRKEMELRMREICAGSKSRTEVVQQSLEMYREVFIHTQRRIN 613

Query: 296 KVK 298
            +K
Sbjct: 614 MLK 616