Result of FASTA (ccds) for pF1KB8499
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8499, 932 aa
  1>>>pF1KB8499 932 - 932 aa - 932 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.6848+/-0.00142; mu= 9.4829+/- 0.084
 mean_var=121.7960+/-24.331, 0's: 0 Z-trim(101.7): 69  B-trim: 44 in 1/48
 Lambda= 0.116214
 statistics sampled from 6575 (6617) to 6575 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.53), E-opt: 0.2 (0.203), width:  16
 Scan time:  4.260

The best scores are:                                      opt bits E(32554)
CCDS2302.1 PMS1 gene_id:5378|Hs108|chr2            ( 932) 6068 1029.8       0
CCDS74615.1 PMS1 gene_id:5378|Hs108|chr2           ( 756) 4962 844.4       0
CCDS46474.1 PMS1 gene_id:5378|Hs108|chr2           ( 893) 4593 782.5       0
CCDS46473.1 PMS1 gene_id:5378|Hs108|chr2           ( 770) 4003 683.6 3.9e-196
CCDS82544.1 PMS1 gene_id:5378|Hs108|chr2           ( 181)  884 160.4 2.8e-39
CCDS82543.1 PMS1 gene_id:5378|Hs108|chr2           ( 165)  882 160.1 3.3e-39
CCDS5343.1 PMS2 gene_id:5395|Hs108|chr7            ( 862)  468 90.9 1.1e-17
CCDS2663.1 MLH1 gene_id:4292|Hs108|chr3            ( 756)  380 76.1 2.8e-13


>>CCDS2302.1 PMS1 gene_id:5378|Hs108|chr2                 (932 aa)
 initn: 6068 init1: 6068 opt: 6068  Z-score: 5504.5  bits: 1029.8 E(32554):    0
Smith-Waterman score: 6068; 100.0% identity (100.0% similar) in 932 aa overlap (1-932:1-932)

               10        20        30        40        50        60
pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
              850       860       870       880       890       900

              910       920       930  
pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
       ::::::::::::::::::::::::::::::::
CCDS23 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
              910       920       930  

>>CCDS74615.1 PMS1 gene_id:5378|Hs108|chr2                (756 aa)
 initn: 4962 init1: 4962 opt: 4962  Z-score: 4503.8  bits: 844.4 E(32554):    0
Smith-Waterman score: 4962; 100.0% identity (100.0% similar) in 756 aa overlap (177-932:1-756)

        150       160       170       180       190       200      
pF1KB8 RLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDH
                                     ::::::::::::::::::::::::::::::
CCDS74                               MSFGILKPDLRIVFVHNKAVIWQKSRVSDH
                                             10        20        30

        210       220       230       240       250       260      
pF1KB8 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP
               40        50        60        70        80        90

        270       280       290       300       310       320      
pF1KB8 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL
              100       110       120       130       140       150

        330       340       350       360       370       380      
pF1KB8 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS
              160       170       180       190       200       210

        390       400       410       420       430       440      
pF1KB8 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW
              220       230       240       250       260       270

        450       460       470       480       490       500      
pF1KB8 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN
              280       290       300       310       320       330

        510       520       530       540       550       560      
pF1KB8 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL
              340       350       360       370       380       390

        570       580       590       600       610       620      
pF1KB8 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK
              400       410       420       430       440       450

        630       640       650       660       670       680      
pF1KB8 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI
              460       470       480       490       500       510

        690       700       710       720       730       740      
pF1KB8 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML
              520       530       540       550       560       570

        750       760       770       780       790       800      
pF1KB8 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST
              580       590       600       610       620       630

        810       820       830       840       850       860      
pF1KB8 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY
              640       650       660       670       680       690

        870       880       890       900       910       920      
pF1KB8 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT
              700       710       720       730       740       750

        930  
pF1KB8 YLPETT
       ::::::
CCDS74 YLPETT
             

>>CCDS46474.1 PMS1 gene_id:5378|Hs108|chr2                (893 aa)
 initn: 4593 init1: 4593 opt: 4593  Z-score: 4168.3  bits: 782.5 E(32554):    0
Smith-Waterman score: 5728; 95.8% identity (95.8% similar) in 932 aa overlap (1-932:1-893)

               10        20        30        40        50        60
pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
       ::::::::::::::                                       :::::::
CCDS46 ILKPDLRIVFVHNK---------------------------------------IYLSGFL
              190                                              200 

              250       260       270       280       290       300
pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
             210       220       230       240       250       260 

              310       320       330       340       350       360
pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
             270       280       290       300       310       320 

              370       380       390       400       410       420
pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
             330       340       350       360       370       380 

              430       440       450       460       470       480
pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
             390       400       410       420       430       440 

              490       500       510       520       530       540
pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
             450       460       470       480       490       500 

              550       560       570       580       590       600
pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
             510       520       530       540       550       560 

              610       620       630       640       650       660
pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW
             570       580       590       600       610       620 

              670       680       690       700       710       720
pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE
             630       640       650       660       670       680 

              730       740       750       760       770       780
pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE
             690       700       710       720       730       740 

              790       800       810       820       830       840
pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
             750       760       770       780       790       800 

              850       860       870       880       890       900
pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
             810       820       830       840       850       860 

              910       920       930  
pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
       ::::::::::::::::::::::::::::::::
CCDS46 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
             870       880       890   

>>CCDS46473.1 PMS1 gene_id:5378|Hs108|chr2                (770 aa)
 initn: 4999 init1: 4003 opt: 4003  Z-score: 3634.7  bits: 683.6 E(32554): 3.9e-196
Smith-Waterman score: 4679; 82.5% identity (82.6% similar) in 932 aa overlap (1-932:1-770)

               10        20        30        40        50        60
pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW
       ::::::::::::::::::                                          
CCDS46 ATLQIEELWKTLSEEEKL------------------------------------------
              610                                                  

              670       680       690       700       710       720
pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE
                                                                   
CCDS46 ------------------------------------------------------------
                                                                   

              730       740       750       760       770       780
pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE
                                                                   
CCDS46 ------------------------------------------------------------
                                                                   

              790       800       810       820       830       840
pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 NLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
      620       630       640       650       660       670        

              850       860       870       880       890       900
pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
      680       690       700       710       720       730        

              910       920       930  
pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
       ::::::::::::::::::::::::::::::::
CCDS46 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
      740       750       760       770

>>CCDS82544.1 PMS1 gene_id:5378|Hs108|chr2                (181 aa)
 initn: 883 init1: 883 opt: 884  Z-score: 818.6  bits: 160.4 E(32554): 2.8e-39
Smith-Waterman score: 884; 94.1% identity (96.1% similar) in 152 aa overlap (1-152:1-149)

               10        20        30        40        50        60
pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
       ::::::::::::::::::::  :.   :. :.                            
CCDS82 YVLDGSGHILSQKPSHLGQGKKVA---LYTNILYLFCLNCWFKKKKLLGEYKYIALGLVL
              130       140          150       160       170       

              190       200       210       220       230       240
pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
                                                                   
CCDS82 IKAS                                                        
       180                                                         

>>CCDS82543.1 PMS1 gene_id:5378|Hs108|chr2                (165 aa)
 initn: 882 init1: 882 opt: 882  Z-score: 817.5  bits: 160.1 E(32554): 3.3e-39
Smith-Waterman score: 882; 99.3% identity (100.0% similar) in 141 aa overlap (1-141:1-141)

               10        20        30        40        50        60
pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
       ::::::::::::::::::::.                                       
CCDS82 YVLDGSGHILSQKPSHLGQGSHSVTQAGLQWHHLGSLQPLPPRLK               
              130       140       150       160                    

>>CCDS5343.1 PMS2 gene_id:5395|Hs108|chr7                 (862 aa)
 initn: 623 init1: 441 opt: 468  Z-score: 430.8  bits: 90.9 E(32554): 1.1e-17
Smith-Waterman score: 625; 26.4% identity (57.9% similar) in 632 aa overlap (1-580:15-625)

                             10        20        30        40      
pF1KB8               MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLEN
                     .: .   .:. . :.:.. :. ..::::.:::::::::..:.::..
CCDS53 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD
               10        20        30        40        50        60

         50        60        70        80        90       100      
pF1KB8 YGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEV
       :: : ::: ::: :..  .   ...:..::::.   :: .. :.:::::::.:.: ...:
CCDS53 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV
               70        80        90       100       110       120

        110       120       130       140       150        160     
pF1KB8 LITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVR-KQFYSTAKKC
        :.:  :. . .:. ..: .:.:... :    .::::.. .::..:::: :.:  . :: 
CCDS53 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKK-
              130       140       150       160       170          

         170       180       190       200            210       220
pF1KB8 KDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDH-----KMALMSVLGTAVMN
         :  :. ..: .. :..  .:.  ... .   ..  :        :  . ::.:   ..
CCDS53 --EYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQ
       180       190       200       210       220       230       

               230                      240       250       260    
pF1KB8 NMESF-QYHSEES---------------QIYLSGFLPKCDADHSFTSLSTPERSFIFINS
       ..  : :    .:                .:.:::. .:   :. .. :. .:.:.::: 
CCDS53 SLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCT--HG-VGRSSTDRQFFFINR
       240       250       260       270          280       290    

          270       280       290       300       310       320    
pF1KB8 RPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKES
       ::     . .:. . :..     . . ::   :.:.: .  ::.:.:::: :.::: .:.
CCDS53 RPCDPAKVCRLVNEVYHMY----NRHQYPFVVLNISVDSECVDINVTPDKRQILLQ-EEK
          300       310           320       330       340          

          330       340       350            360       370         
pF1KB8 VLIALENLMTTCYGPLPSTNSYENNKTDVSAADIV-----LSKTAETDVLFNKVESSGKN
       .:.:.  : :.  : . :    . :: .::   ..     : :   .:.    ::.. ..
CCDS53 LLLAV--LKTSLIGMFDS----DVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQS
     350         360           370       380       390       400   

     380             390       400       410       420       430   
pF1KB8 YS------NVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTK
        :      . :.:.    . ...  : ..: .   :. .  .   .  ... . ....:.
CCDS53 PSLRTGEEKKDVSI----SRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTS
           410           420       430       440       450         

           440       450       460       470       480       490   
pF1KB8 NAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEI
       .:..: ..   . :  .. .. .   . ..  .. . ..  .:  : .  ..: . ::: 
CCDS53 GAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEY
     460       470       480       490       500       510         

               500           510       520           530           
pF1KB8 SA----DEWSRGNILKN----SVGENIEPVKILVPEKSLPCKV----SNNNYPIP-----
       .:    :. :. .. ..    .. ...  :     ...  ::     . .:   :     
CCDS53 AASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRF
     520       530       540       550       560       570         

          540       550       560       570       580       590    
pF1KB8 --EQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENP
         :..  . : :.:  :. : ....: .   ....:.   .: :.:              
CCDS53 KKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQS
     580       590       600       610       620       630         

          600       610       620       630       640       650    
pF1KB8 KTSLEDATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKI
                                                                   
CCDS53 EGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVD
     640       650       660       670       680       690         

>>CCDS2663.1 MLH1 gene_id:4292|Hs108|chr3                 (756 aa)
 initn: 373 init1: 324 opt: 380  Z-score: 352.0  bits: 76.1 E(32554): 2.8e-13
Smith-Waterman score: 439; 22.0% identity (55.7% similar) in 738 aa overlap (1-675:8-727)

                      10        20        30        40        50   
pF1KB8        MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIE
              ...:  ..:  ......:   ....::.::: ::: .::..: ... :.  :.
CCDS26 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KB8 VRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTA
       ..::: ::.  :  ..  .. :::..: ::: ...:::::::::.::  .:.: :::.::
CCDS26 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTA
               70        80        90       100       110       120

           120       130        140       150       160       170  
pF1KB8 ADNFSTQYVLDGSGHILSQ-KPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKI
        :.  .  .  ..:.. .  ::   .::: .:.  :: :. .:..   . :. ..:  ::
CCDS26 -DGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRK---ALKNPSEEYGKI
               130       140       150       160          170      

            180       190       200         210       220       230
pF1KB8 QDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDHKMA--LMSVLGTAVMNNMESFQYHSE
        ...  ... .  . .   ..  .. .   . . . .  . :..:.::  ..  .  ...
CCDS26 LEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDK
        180       190       200       210       220       230      

              240       250       260       270       280       290
pF1KB8 ESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTR
          . ..:..   .:..:  .       ..::: : :.. .. : :.  :     :..  
CCDS26 TLAFKMNGYIS--NANYSVKKCIF----LLFINHRLVESTSLRKAIETVYAAYLPKNT--
        240         250           260       270       280          

              300       310       320       330                    
pF1KB8 LYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALEN-------------------
        .: ..:....   .::::. : : .: . ..::.:  ...                   
CCDS26 -HPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQT
       290       300       310       320       330       340       

                 340       350       360       370           380   
pF1KB8 LMTTCYGP----LPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESS----GKNYSNV
       :.    ::    . ::.:  ...:. :.  .   . ..::   .:...     .:  :. 
CCDS26 LLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQ
       350       360       370       380       390       400       

           390        400                 410       420            
pF1KB8 DTSVIPF-QNDMHNDESGKNTDDCLN----------HQISIGDFGYGHCSSEISN----I
         ...   ..:. . .. .. .. :.          .:   ::   :  .::.:.     
CCDS26 PQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKG--TSEMSEKRGPT
       410       420       430       440       450         460     

      430       440       450              460       470           
pF1KB8 DKNTKNAFQDISMSNVSWENSQTEYSKTCF-------ISSVKHTQSENGNKDH--IDESG
       ..: ..  .. :  ..  ..:. :.. .:        ..::   : : ... :  . :  
CCDS26 SSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREML
         470       480       490       500       510       520     

     480       490       500        510       520        530       
pF1KB8 ENEEEAGLENSSEISADEWSRGNILKNS-VGENIEPVKILVPE-KSLPCKVSNNNYPIPE
       .:.  .:  : .   :.. ..  .:... ..:..   .::. .  ..     ..  :. .
CCDS26 HNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELF-YQILIYDFANFGVLRLSEPAPLFD
         530       540       550       560        570       580    

       540       550       560       570        580             590
pF1KB8 QMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKP-MSASALFVQ-DHRPQF-----L
          :  ::   .:.  .. . :    . . . . ::  : :. . .. :.. ..     :
CCDS26 LAMLALDS--PESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLL
          590         600       610       620       630       640  

              600       610       620       630       640       650
pF1KB8 IENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDG
       :.:    ::   . : .:   .. .:. .  :. .:.   . :  :. : .:: .: ...
CCDS26 IDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQS
            650       660       670       680       690       700  

              660       670       680       690       700       710
pF1KB8 RKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINF
       .   .  ..:. . .: .  .: ..                                   
CCDS26 EVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC      
            710       720       730       740       750            




932 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 18:09:55 2016 done: Sun Nov  6 18:09:56 2016
 Total Scan time:  4.260 Total Display time:  0.190

Function used was FASTA [36.3.4 Apr, 2011]
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