Result of FASTA (omim) for pF1KE1246
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE1246, 482 aa
  1>>>pF1KE1246 482 - 482 aa - 482 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6043+/-0.000374; mu= 16.0641+/- 0.023
 mean_var=67.4981+/-13.781, 0's: 0 Z-trim(113.4): 178  B-trim: 327 in 1/49
 Lambda= 0.156109
 statistics sampled from 22602 (22780) to 22602 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.267), width:  16
 Scan time:  9.410

The best scores are:                                      opt bits E(85289)
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 3237 738.2 1.2e-212
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 3144 717.2 2.5e-206
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 2578 589.7 5.5e-168
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 2578 589.8 5.6e-168
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 1164 271.3 3.9e-72
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1164 271.3 4.3e-72
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1164 271.3 4.4e-72
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1165 271.6 4.6e-72
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1163 271.1 5.5e-72
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1127 263.0 1.4e-69
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1117 260.7 6.7e-69
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1113 259.8 1.3e-68
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1113 259.8 1.3e-68
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1113 259.8 1.3e-68
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1110 259.2 2.1e-68
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1106 258.2 3.5e-68
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1032 241.6 3.7e-63
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502)  976 229.0 2.4e-59
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556)  975 228.8 3.1e-59
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424)  964 226.2 1.4e-58
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424)  964 226.2 1.4e-58
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449)  964 226.2 1.4e-58
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462)  964 226.2 1.5e-58
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463)  964 226.3 1.5e-58
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468)  964 226.3 1.5e-58
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468)  964 226.3 1.5e-58
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495)  964 226.3 1.6e-58
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495)  964 226.3 1.6e-58
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498)  964 226.3 1.6e-58
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329)  886 208.6 2.1e-53
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370)  882 207.7 4.4e-53
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370)  882 207.7 4.4e-53
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450)  871 205.3 2.9e-52
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486)  845 199.5 1.8e-50
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502)  845 199.5 1.9e-50
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531)  845 199.5   2e-50
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479)  835 197.2 8.5e-50
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451)  757 179.6 1.6e-44
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451)  757 179.6 1.6e-44
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331)  719 171.0 4.5e-42
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331)  719 171.0 4.5e-42
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380)  698 166.3 1.4e-40
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401)  697 166.1 1.7e-40
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440)  693 165.2 3.4e-40
XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441)  693 165.2 3.4e-40
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412)  692 165.0 3.7e-40
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412)  692 165.0 3.7e-40
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332)  612 146.9 8.1e-35
XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316)  580 139.7 1.1e-32
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463)  559 135.0 4.3e-31


>>NP_001034612 (OMIM: 100690,253290,601462,608930) acety  (482 aa)
 initn: 3237 init1: 3237 opt: 3237  Z-score: 3938.6  bits: 738.2 E(85289): 1.2e-212
Smith-Waterman score: 3237; 100.0% identity (100.0% similar) in 482 aa overlap (1-482:1-482)

               10        20        30        40        50        60
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE1 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE1 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE1 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE1 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE1 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE1 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
              430       440       450       460       470       480

         
pF1KE1 QG
       ::
NP_001 QG
         

>>XP_016858745 (OMIM: 100690,253290,601462,608930) PREDI  (489 aa)
 initn: 3144 init1: 3144 opt: 3144  Z-score: 3825.3  bits: 717.2 E(85289): 2.5e-206
Smith-Waterman score: 3144; 98.9% identity (99.4% similar) in 476 aa overlap (7-482:14-489)

                      10        20        30        40        50   
pF1KE1        MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
                    .:. :  ::::::::::::::::::::::::::::::::::::::::
XP_016 MFMCLEGGEKNLTVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KE1 GLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWN
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KE1 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
              130       140       150       160       170       180

           180       190       200       210       220       230   
pF1KE1 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
              190       200       210       220       230       240

           240       250       260       270       280       290   
pF1KE1 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
              250       260       270       280       290       300

           300       310       320       330       340       350   
pF1KE1 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
              310       320       330       340       350       360

           360       370       380       390       400       410   
pF1KE1 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
              370       380       390       400       410       420

           420       430       440       450       460       470   
pF1KE1 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
              430       440       450       460       470       480

           480  
pF1KE1 RLIELNQQG
       :::::::::
XP_016 RLIELNQQG
                

>>NP_000070 (OMIM: 100690,253290,601462,608930) acetylch  (457 aa)
 initn: 2567 init1: 2567 opt: 2578  Z-score: 3136.8  bits: 589.7 E(85289): 5.5e-168
Smith-Waterman score: 3000; 94.8% identity (94.8% similar) in 482 aa overlap (1-482:1-457)

               10        20        30        40        50        60
pF1KE1 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE1 INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
       ::::::::::::::::::                         :::::::::::::::::
NP_000 INVDEVNQIVTTNVRLKQ-------------------------QWVDYNLKWNPDDYGGV
               70                                 80        90     

              130       140       150       160       170       180
pF1KE1 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
         100       110       120       130       140       150     

              190       200       210       220       230       240
pF1KE1 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
         160       170       180       190       200       210     

              250       260       270       280       290       300
pF1KE1 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
         220       230       240       250       260       270     

              310       320       330       340       350       360
pF1KE1 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
         280       290       300       310       320       330     

              370       380       390       400       410       420
pF1KE1 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
         340       350       360       370       380       390     

              430       440       450       460       470       480
pF1KE1 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
         400       410       420       430       440       450     

         
pF1KE1 QG
       ::
NP_000 QG
         

>>XP_016858746 (OMIM: 100690,253290,601462,608930) PREDI  (464 aa)
 initn: 2567 init1: 2567 opt: 2578  Z-score: 3136.7  bits: 589.8 E(85289): 5.6e-168
Smith-Waterman score: 2907; 93.7% identity (94.1% similar) in 476 aa overlap (7-482:14-464)

                      10        20        30        40        50   
pF1KE1        MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
                    .:. :  ::::::::::::::::::::::::::::::::::::::::
XP_016 MFMCLEGGEKNLTVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTV
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KE1 GLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWN
       :::::::::::::::::::::::::                         ::::::::::
XP_016 GLQLIQLINVDEVNQIVTTNVRLKQ-------------------------QWVDYNLKWN
               70        80                                 90     

           120       130       140       150       160       170   
pF1KE1 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYC
         100       110       120       130       140       150     

           180       190       200       210       220       230   
pF1KE1 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSV
         160       170       180       190       200       210     

           240       250       260       270       280       290   
pF1KE1 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSIS
         220       230       240       250       260       270     

           300       310       320       330       340       350   
pF1KE1 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVM
         280       290       300       310       320       330     

           360       370       380       390       400       410   
pF1KE1 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIK
         340       350       360       370       380       390     

           420       430       440       450       460       470   
pF1KE1 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG
         400       410       420       430       440       450     

           480  
pF1KE1 RLIELNQQG
       :::::::::
XP_016 RLIELNQQG
         460    

>>XP_006720445 (OMIM: 118503,612052) PREDICTED: neuronal  (438 aa)
 initn: 1431 init1: 583 opt: 1164  Z-score: 1416.0  bits: 271.3 E(85289): 3.9e-72
Smith-Waterman score: 1322; 47.0% identity (70.3% similar) in 455 aa overlap (59-471:3-428)

       30        40        50        60        70        80        
pF1KE1 AKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPS
                                     ::..:::::::. ::. :::          
XP_006                             MSQLVKVDEVNQIMETNLWLKQ----------
                                           10        20            

       90       100       110       120       130       140        
pF1KE1 CVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIV
                       : ::.:::::.::::.. ...:..:::.::.:::::: ::: . 
XP_006 ---------------IWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVD
                            30        40        50        60       

      150       160       170       180       190       200        
pF1KE1 KFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESD
         ::.::.:::..:: ::::::: :.: ::.:::: :::.::.:.:.:: . . .   ..
XP_006 DKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGS
        70        80        90       100       110       120       

      210       220       230       240       250       260        
pF1KE1 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL
       . .:... :::::.: .. :.::.. :.:: .  : :::: . ..::::.. .:.:::::
XP_006 SMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLIIPCL
       130       140       150       160        170       180      

      270       280       290       300       310       320        
pF1KE1 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV
       :.:::: ::::::.: :::.:: ::::::::::::::.: ::::: ..::::.:.::::.
XP_006 LISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMI
        190       200       210       220       230       240      

      330       340       350       360       370       380        
pF1KE1 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE----KQDK
       ::  ::.:::.:.:.:.:.:.::.::.::. ::.. .: .::   : ::. .    .. .
XP_006 FVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMF---MTRPTSNEGNAQKPR
        250       260       270       280          290       300   

          390                 400         410                      
pF1KE1 KIFTEDI-DISDIS---------GKPGPPPM-GF-HSPLIK-------------------
        ..  .. ... .:         : :    : :. :   ::                   
XP_006 PLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA
           310       320       330       340       350       360   

                  420       430       440       450       460      
pF1KE1 -------HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIG
               ::.: ::...:::::.::...:...   .:::::::.:.:.: :: ::::.:
XP_006 VLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILG
           370       380       390       400       410       420   

        470       480  
pF1KE1 TLAVFAGRLIELNQQG
       : ..:           
XP_006 TAGLFLQPLMAREDA 
           430         

>>NP_001160166 (OMIM: 118503,612052) neuronal acetylchol  (489 aa)
 initn: 1394 init1: 583 opt: 1164  Z-score: 1415.3  bits: 271.3 E(85289): 4.3e-72
Smith-Waterman score: 1290; 44.7% identity (68.3% similar) in 479 aa overlap (1-437:12-461)

                          10        20        30        40         
pF1KE1            MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVV
                  . :  ::::. :    .. .:: : ::  .::.::. ..::: .  . :
NP_001 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
               10        20        30        40        50        60

      50        60        70        80        90       100         
pF1KE1 EVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYN
        .   ... ::..:::::::. ::. :::                          : ::.
NP_001 IIHFEVSMSQLVKVDEVNQIMETNLWLKQ-------------------------IWNDYK
               70        80                                 90     

     110       120       130       140       150       160         
pF1KE1 LKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIF
       :::::.::::.. ...:..:::.::.:::::: ::: .   ::.::.:::..:: :::::
NP_001 LKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIF
         100       110       120       130       140       150     

     170       180       190       200       210       220         
pF1KE1 KSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGW
       :: :.: ::.:::: :::.::.:.:.:: . . .   ... .:... :::::.: .. :.
NP_001 KSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGY
         160       170       180       190       200       210     

     230       240       250       260       270       280         
pF1KE1 KHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMT
       ::.. :.:: .  : :::: . ..::::.. .:.::::::.:::: ::::::.: :::.:
NP_001 KHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT
         220        230       240       250       260       270    

     290       300       310       320       330       340         
pF1KE1 LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
       : ::::::::::::::.: ::::: ..::::.:.::::.::  ::.:::.:.:.:.:.:.
NP_001 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT
          280       290       300       310       320       330    

     350       360       370       380           390               
pF1KE1 THVMPNWVRKVFIDTIPNIMFFSTMKRPSRE----KQDKKIFTEDI-DISDIS-------
       ::.::.::. ::.. .: .::   : ::. .    .. . ..  .. ... .:       
NP_001 THTMPSWVKTVFLNLLPRVMF---MTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGC
          340       350          360       370       380       390 

         400         410                                 420       
pF1KE1 --GKPGPPPM-GF-HSPLIK--------------------------HPEVKSAIEGIKYI
         : :    : :. :   ::                           ::.: ::...:::
NP_001 KEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYI
             400       410       420       430       440       450 

       430       440       450       460       470       480  
pF1KE1 AETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
       ::.::...:.                                             
NP_001 AENMKAQNEAKEEQKAQEIQQLKRKEKSTETSDQEPGL                 
             460       470       480                          

>>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine  (505 aa)
 initn: 1523 init1: 583 opt: 1164  Z-score: 1415.1  bits: 271.3 E(85289): 4.4e-72
Smith-Waterman score: 1419; 45.4% identity (69.2% similar) in 513 aa overlap (1-471:12-495)

                          10        20        30        40         
pF1KE1            MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVV
                  . :  ::::. :    .. .:: : ::  .::.::. ..::: .  . :
NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
               10        20        30        40        50        60

      50        60        70        80        90       100         
pF1KE1 EVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYN
        .   ... ::..:::::::. ::. :::                          : ::.
NP_000 IIHFEVSMSQLVKVDEVNQIMETNLWLKQ-------------------------IWNDYK
               70        80                                 90     

     110       120       130       140       150       160         
pF1KE1 LKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIF
       :::::.::::.. ...:..:::.::.:::::: ::: .   ::.::.:::..:: :::::
NP_000 LKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIF
         100       110       120       130       140       150     

     170       180       190       200       210       220         
pF1KE1 KSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGW
       :: :.: ::.:::: :::.::.:.:.:: . . .   ... .:... :::::.: .. :.
NP_000 KSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGY
         160       170       180       190       200       210     

     230       240       250       260       270       280         
pF1KE1 KHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMT
       ::.. :.:: .  : :::: . ..::::.. .:.::::::.:::: ::::::.: :::.:
NP_000 KHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT
         220        230       240       250       260       270    

     290       300       310       320       330       340         
pF1KE1 LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
       : ::::::::::::::.: ::::: ..::::.:.::::.::  ::.:::.:.:.:.:.:.
NP_000 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT
          280       290       300       310       320       330    

     350       360       370       380           390               
pF1KE1 THVMPNWVRKVFIDTIPNIMFFSTMKRPSRE----KQDKKIFTEDI-DISDIS-------
       ::.::.::. ::.. .: .::   : ::. .    .. . ..  .. ... .:       
NP_000 THTMPSWVKTVFLNLLPRVMF---MTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGC
          340       350          360       370       380       390 

         400         410                                 420       
pF1KE1 --GKPGPPPM-GF-HSPLIK--------------------------HPEVKSAIEGIKYI
         : :    : :. :   ::                           ::.: ::...:::
NP_000 KEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYI
             400       410       420       430       440       450 

       430       440       450       460       470       480  
pF1KE1 AETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
       ::.::...:...   .:::::::.:.:.: :: ::::.:: ..:           
NP_000 AENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA 
             460       470       480       490       500      

>>NP_000735 (OMIM: 118504,188890,600513) neuronal acetyl  (627 aa)
 initn: 1283 init1: 587 opt: 1165  Z-score: 1414.8  bits: 271.6 E(85289): 4.6e-72
Smith-Waterman score: 1283; 50.4% identity (71.6% similar) in 409 aa overlap (5-406:14-390)

                        10        20               30        40    
pF1KE1          MEPWPLLLLFSLCSAGLVLGSEH-------ETRLVAKLFKDYSSVVRPVED
                    :::::.   ..::. .: :       : ::. :::. :..  ::: .
NP_000 MELGGPGAPRLLPPLLLLL---GTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVAN
               10           20        30        40        50       

           50        60        70        80        90       100    
pF1KE1 HRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQ
         .:: :  ::.. :::.::: ::..:::: .::                         .
NP_000 ISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQ-------------------------E
        60        70        80        90                           

          110       120       130       140       150       160    
pF1KE1 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWT
       : ::.:.:.: :: .: .:.:::: :::::.:::::::::::....::. : . :.. ::
NP_000 WHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWT
            100       110       120       130       140       150  

          170       180       190       200       210       220    
pF1KE1 PPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIK
       ::::.:: : : :: ::::.:::.::.:.:::: . . .    .. :  .: ::::::: 
NP_000 PPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIV
            160       170       180       190       200       210  

          230       240       250       260       270       280    
pF1KE1 ESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS
       .. :  ..  : :: .  : :::: ::..::::.. .:.::::::.: :: ::::::.. 
NP_000 DAVGTYNTRKYECCAEI-YPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSEC
            220        230       240       250       260       270 

          290       300       310       320       330       340    
pF1KE1 GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTH
       :::.:: ::::::::::::.:.:.::::: ..::::.:.::::.::  ::.:::.:.:.:
NP_000 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH
             280       290       300       310       320       330 

          350       360       370       380       390       400    
pF1KE1 HRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPP
       :::: ::.::.:::.::.: .: ...   :::::  :.. . . :..     . .  : :
NP_000 HRSPRTHTMPTWVRRVFLDIVPRLLL---MKRPSVVKDNCRRLIESMHKMASAPRFWPEP
             340       350          360       370       380        

          410       420       430       440       450       460    
pF1KE1 MGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI
        :                                                          
NP_000 EGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGP
      390       400       410       420       430       440        

>--
 initn: 221 init1: 173 opt: 211  Z-score: 253.6  bits: 56.7 E(85289): 2.2e-07
Smith-Waterman score: 211; 42.9% identity (77.1% similar) in 70 aa overlap (402-471:554-618)

             380       390       400       410       420       430 
pF1KE1 STMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETM
                                     :::   : ::   : .  :.::..:::. .
NP_000 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPP---HLPL--SPALTRAVEGVQYIADHL
           530       540       550          560         570        

             440       450       460       470       480  
pF1KE1 KSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
       :... . ..  .:::::::.:.:.: .:..::..::...:           
NP_000 KAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI  
      580       590       600       610       620         

>>XP_016883113 (OMIM: 118504,188890,600513) PREDICTED: n  (546 aa)
 initn: 1283 init1: 587 opt: 1163  Z-score: 1413.3  bits: 271.1 E(85289): 5.5e-72
Smith-Waterman score: 1163; 55.3% identity (78.6% similar) in 304 aa overlap (103-406:10-309)

             80        90       100       110       120       130  
pF1KE1 NVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWR
                                     ..: ::.:.:.: :: .: .:.:::: :::
XP_016                      MMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
                                    10        20        30         

            140       150       160       170       180       190  
pF1KE1 PDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLG
       ::.:::::::::::....::. : . :.. ::::::.:: : : :: ::::.:::.::.:
XP_016 PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
      40        50        60        70        80        90         

            200       210       220       230       240       250  
pF1KE1 TWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVM
       .:::: . . .    .. :  .: ::::::: .. :  ..  : :: .  : :::: ::.
XP_016 SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEI-YPDITYAFVI
     100       110       120       130       140        150        

            260       270       280       290       300       310  
pF1KE1 QRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPST
       .::::.. .:.::::::.: :: ::::::.. :::.:: ::::::::::::.:.:.::::
XP_016 RRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPST
      160       170       180       190       200       210        

            320       330       340       350       360       370  
pF1KE1 SSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFS
       : ..::::.:.::::.::  ::.:::.:.:.::::: ::.::.:::.::.: .: ...  
XP_016 SLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLL--
      220       230       240       250       260       270        

            380       390       400       410       420       430  
pF1KE1 TMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMK
        :::::  :.. . . :..     . .  : : :                          
XP_016 -MKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPA
         280       290       300       310       320       330     

            440       450       460       470       480            
pF1KE1 SDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG          
                                                                   
XP_016 EPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGE
         340       350       360       370       380       390     

>--
 initn: 221 init1: 173 opt: 211  Z-score: 254.6  bits: 56.7 E(85289): 1.9e-07
Smith-Waterman score: 211; 42.9% identity (77.1% similar) in 70 aa overlap (402-471:473-537)

             380       390       400       410       420       430 
pF1KE1 STMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETM
                                     :::   : ::   : .  :.::..:::. .
XP_016 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPP---HLPL--SPALTRAVEGVQYIADHL
            450       460       470            480       490       

             440       450       460       470       480  
pF1KE1 KSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
       :... . ..  .:::::::.:.:.: .:..::..::...:           
XP_016 KAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI  
       500       510       520       530       540        

>>NP_001186208 (OMIM: 606888) neuronal acetylcholine rec  (479 aa)
 initn: 1369 init1: 565 opt: 1127  Z-score: 1370.4  bits: 263.0 E(85289): 1.4e-69
Smith-Waterman score: 1267; 45.3% identity (74.3% similar) in 413 aa overlap (87-471:58-468)

         60        70        80        90       100       110      
pF1KE1 LIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDD
                                     :  : . : . ..: :  : ::.:.:.: .
NP_001 CVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAI-TQLANVIWNDYKLRWDPME
        30        40        50        60         70        80      

        120       130       140       150       160       170      
pF1KE1 YGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEII
       : :.. ...:..:::.::.:::::: ::: .   ::.::.:.: ::::::::::: : . 
NP_001 YDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMD
         90       100       110       120       130       140      

        180       190       200       210       220       230      
pF1KE1 VTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYS
       .: ::::.::::.:.:.:::: . . .   ... :...: :..:: : .. :.::.. :.
NP_001 ITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYN
        150       160       170       180       190       200      

        240       250       260       270       280       290      
pF1KE1 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL
       :: .  : :::: : ..:::... .:.:::::..:::: ::::::.: :::.:: :::::
NP_001 CCEEI-YTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLL
        210        220       230       240       250       260     

        300       310       320       330       340       350      
pF1KE1 SLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNW
       :::::::::.: ::::: .:::.:.:.::::.::  ::..::.:.: :.:.:.::.:: :
NP_001 SLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRW
         270       280       290       300       310       320     

        360       370                        380                   
pF1KE1 VRKVFIDTIPNIMFF-----------------STMKRPSREK--------QDKKIFT--E
       :. ::.  .:.....                 .  .::.. :        . :. :   .
NP_001 VKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHK
         330       340       350       360       370       380     

     390       400       410        420       430       440        
pF1KE1 DIDISDISGKPGPPPMGFHSPLIKH-PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVA
       . ...  . . .  :. .     .: :::...:.....:::.::: .:....  .:::::
NP_001 SNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVA
         390       400       410       420       430       440     

      450       460       470       480  
pF1KE1 MVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
       ::.:...: ::..::..:: ..:           
NP_001 MVVDRVFLWVFIIVCVFGTAGLFLQPLLGNTGKS
         450       460       470         




482 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 18:11:49 2016 done: Sun Nov  6 18:11:50 2016
 Total Scan time:  9.410 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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