Result of FASTA (omim) for pF1KB4983
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4983, 509 aa
  1>>>pF1KB4983 509 - 509 aa - 509 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2604+/-0.000509; mu= 18.1644+/- 0.031
 mean_var=65.2055+/-13.274, 0's: 0 Z-trim(108.1): 47  B-trim: 629 in 2/48
 Lambda= 0.158830
 statistics sampled from 16179 (16213) to 16179 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.543), E-opt: 0.2 (0.19), width:  16
 Scan time:  8.680

The best scores are:                                      opt bits E(85289)
NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehy ( 509) 3324 771.2       0
NP_001276680 (OMIM: 238331,246900) dihydrolipoyl d ( 486) 2725 633.9 3.1e-181
NP_001276679 (OMIM: 238331,246900) dihydrolipoyl d ( 410) 2649 616.5 4.7e-176
NP_001276681 (OMIM: 238331,246900) dihydrolipoyl d ( 461) 2052 479.7 7.8e-135
NP_000628 (OMIM: 138300) glutathione reductase, mi ( 522)  644 157.1 1.1e-37
NP_001248375 (OMIM: 601112) thioredoxin reductase  ( 461)  601 147.2 9.6e-35
NP_877393 (OMIM: 601112) thioredoxin reductase 1,  ( 499)  601 147.2   1e-34
NP_877420 (OMIM: 601112) thioredoxin reductase 1,  ( 499)  601 147.2   1e-34
NP_877419 (OMIM: 601112) thioredoxin reductase 1,  ( 499)  601 147.2   1e-34
NP_001248374 (OMIM: 601112) thioredoxin reductase  ( 549)  601 147.3 1.1e-34
NP_003321 (OMIM: 601112) thioredoxin reductase 1,  ( 551)  601 147.3 1.1e-34
NP_001087240 (OMIM: 601112) thioredoxin reductase  ( 649)  601 147.3 1.3e-34
NP_006431 (OMIM: 606448) thioredoxin reductase 2,  ( 524)  569 139.9 1.7e-32
NP_443115 (OMIM: 606235) thioredoxin reductase 3 i ( 643)  563 138.6 5.3e-32
NP_001182031 (OMIM: 138300) glutathione reductase, ( 493)  356 91.1   8e-18
NP_001269441 (OMIM: 606448) thioredoxin reductase  ( 338)  326 84.1 6.9e-16
NP_001182033 (OMIM: 138300) glutathione reductase, ( 440)  311 80.8 9.3e-15
NP_001182032 (OMIM: 138300) glutathione reductase, ( 469)  307 79.9 1.9e-14
NP_001185625 (OMIM: 605159) apoptosis-inducing fac ( 373)  147 43.1  0.0017
NP_116186 (OMIM: 605159) apoptosis-inducing factor ( 373)  147 43.1  0.0017


>>NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehydrog  (509 aa)
 initn: 3324 init1: 3324 opt: 3324  Z-score: 4116.3  bits: 771.2 E(85289):    0
Smith-Waterman score: 3324; 99.8% identity (100.0% similar) in 509 aa overlap (1-509:1-509)

               10        20        30        40        50        60
pF1KB4 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
       ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_000 IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
              430       440       450       460       470       480

              490       500         
pF1KB4 ARVCHAHPTLSEAFREANLAASFGKSINF
       :::::::::::::::::::::::::::::
NP_000 ARVCHAHPTLSEAFREANLAASFGKSINF
              490       500         

>>NP_001276680 (OMIM: 238331,246900) dihydrolipoyl dehyd  (486 aa)
 initn: 2725 init1: 2725 opt: 2725  Z-score: 3374.8  bits: 633.9 E(85289): 3.1e-181
Smith-Waterman score: 3107; 95.3% identity (95.5% similar) in 509 aa overlap (1-509:1-486)

               10        20        30        40        50        60
pF1KB4 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
       ::::::                       :::::::::::::::::::::::::::::::
NP_001 AQLGFK-----------------------ALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
                                      70        80        90       

              130       140       150       160       170       180
pF1KB4 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB4 IATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
       ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
       160       170       180       190       200       210       

              250       260       270       280       290       300
pF1KB4 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
       220       230       240       250       260       270       

              310       320       330       340       350       360
pF1KB4 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
       280       290       300       310       320       330       

              370       380       390       400       410       420
pF1KB4 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
       340       350       360       370       380       390       

              430       440       450       460       470       480
pF1KB4 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
       400       410       420       430       440       450       

              490       500         
pF1KB4 ARVCHAHPTLSEAFREANLAASFGKSINF
       :::::::::::::::::::::::::::::
NP_001 ARVCHAHPTLSEAFREANLAASFGKSINF
       460       470       480      

>>NP_001276679 (OMIM: 238331,246900) dihydrolipoyl dehyd  (410 aa)
 initn: 2649 init1: 2649 opt: 2649  Z-score: 3281.8  bits: 616.5 E(85289): 4.7e-176
Smith-Waterman score: 2649; 99.8% identity (100.0% similar) in 410 aa overlap (100-509:1-410)

      70        80        90       100       110       120         
pF1KB4 IEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKST
                                     ::::::::::::::::::::::::::::::
NP_001                               MAHGKDFASRGIEMSEVRLNLDKMMEQKST
                                             10        20        30

     130       140       150       160       170       180         
pF1KB4 AVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTP
               40        50        60        70        80        90

     190       200       210       220       230       240         
pF1KB4 FPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVG
       :::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 FPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVG
              100       110       120       130       140       150

     250       260       270       280       290       300         
pF1KB4 GVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL
              160       170       180       190       200       210

     310       320       330       340       350       360         
pF1KB4 LVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDE
              220       230       240       250       260       270

     370       380       390       400       410       420         
pF1KB4 GIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRA
              280       290       300       310       320       330

     430       440       450       460       470       480         
pF1KB4 KTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPT
              340       350       360       370       380       390

     490       500         
pF1KB4 LSEAFREANLAASFGKSINF
       ::::::::::::::::::::
NP_001 LSEAFREANLAASFGKSINF
              400       410

>>NP_001276681 (OMIM: 238331,246900) dihydrolipoyl dehyd  (461 aa)
 initn: 2052 init1: 2052 opt: 2052  Z-score: 2541.7  bits: 479.7 E(85289): 7.8e-135
Smith-Waterman score: 2915; 90.4% identity (90.6% similar) in 509 aa overlap (1-509:1-461)

               10        20        30        40        50        60
pF1KB4 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
       ::::::::::::::::::::::::::                                  
NP_001 DKMMEQKSTAVKALTGGIAHLFKQNK----------------------------------
              130       140                                        

              190       200       210       220       230       240
pF1KB4 IATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
                     ::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 --------------IDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
                      150       160       170       180       190  

              250       260       270       280       290       300
pF1KB4 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
            200       210       220       230       240       250  

              310       320       330       340       350       360
pF1KB4 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
            260       270       280       290       300       310  

              370       380       390       400       410       420
pF1KB4 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
            320       330       340       350       360       370  

              430       440       450       460       470       480
pF1KB4 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
            380       390       400       410       420       430  

              490       500         
pF1KB4 ARVCHAHPTLSEAFREANLAASFGKSINF
       :::::::::::::::::::::::::::::
NP_001 ARVCHAHPTLSEAFREANLAASFGKSINF
            440       450       460 

>>NP_000628 (OMIM: 138300) glutathione reductase, mitoch  (522 aa)
 initn: 519 init1: 146 opt: 644  Z-score: 797.2  bits: 157.1 E(85289): 1.1e-37
Smith-Waterman score: 644; 30.5% identity (63.3% similar) in 463 aa overlap (43-492:66-516)

             20        30        40        50        60        70  
pF1KB4 KRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK
                                     :  :::.: :: ..: .::.:: ... .:.
NP_000 LTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVES
          40        50        60        70        80        90     

             80        90       100       110       120       130  
pF1KB4 NETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVK
       .. :::::.::::.:.:.. :.. . .. :  : :. :.   : ..:   . :.... :.
NP_000 HK-LGGTCVNVGCVPKKVMWNTAVHSEFMH--DHADYGFPSCEGKFNWRVIKEKRDAYVS
          100       110       120         130       140       150  

            140       150       160       170       180            
pF1KB4 ALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGS-EVTP--
        :..   . . ....  . :.. .:.  . :  ...:  .   . .::::::.   ::  
NP_000 RLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI-EVSG--KKYTAPHILIATGGMPSTPHE
            160       170       180          190       200         

       190       200       210       220       230       240       
pF1KB4 --FPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH
         .:: ..     ..: : ......: . :..::: :.::.... . ::. .. .    .
NP_000 SQIPGASLG----ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDK
     210           220       230       240       250       260     

       250       260       270       280       290       300       
pF1KB4 VGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT--
       :   ..:  :: :  . :.. : .  :. . .  .::. . ..::. .:  :.  :.:  
NP_000 VLR-SFDSMISTNCTEELENAGVEV-LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMI
          270       280        290       300       310       320   

           310       320       330       340       350       360   
pF1KB4 --CDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLA
          : ::  ::: : ::.:.:..:::. : .:.: :.   .:.. .:::.::: .  .:.
NP_000 PDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLT
           330       340       350       360       370       380   

           370         380       390       400        410          
pF1KB4 HKAEDEGIICVEGM--AGGAVHIDYNCVPSVIYTHPEVAWVGKSE-EQLKEEGIE-YKVG
         :   :   .. .       ..::: .:.:...:: .. :: .: : ... :::  :. 
NP_000 PVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTY
           390       400       410       420       430       440   

     420       430       440       450       460       470         
pF1KB4 KFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCED
       .  :.   .: :.  :  ..:..  .. ..:.: :. : :  ::..  :.:...::.  :
NP_000 STSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKAD
           450       460       470       480       490       500   

     480       490       500         
pF1KB4 IARVCHAHPTLSEAFREANLAASFGKSINF
       .  .   ::: ::                 
NP_000 FDNTVAIHPTSSEELVTLR           
           510       520             

>>NP_001248375 (OMIM: 601112) thioredoxin reductase 1, c  (461 aa)
 initn: 515 init1: 133 opt: 601  Z-score: 744.8  bits: 147.2 E(85289): 9.6e-35
Smith-Waterman score: 628; 30.3% identity (63.5% similar) in 446 aa overlap (76-507:17-454)

          50        60        70        80        90       100     
pF1KB4 VIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKD
                                     :::::.::::::.: :....    .:  .:
NP_001               MVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QD
                             10        20        30         40     

         110        120       130       140       150       160    
pF1KB4 FASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTA
         . : .. : :. . :.:.:  .. . .:. :    ....:::. :.::.. : ... :
NP_001 SRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKA
           50        60        70        80        90       100    

          170       180       190       200       210       220    
pF1KB4 TKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVI
       :.  :  .. ... .::::: :   . ::  :..  .::   .:.   : : .:.::. .
NP_001 TNNKGKEKIYSAERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYV
          110       120        130       140       150       160   

          230       240       250       260       270          280 
pF1KB4 GVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGA
       ..: ..    .: :::..  .  .   :.:....... . ....:.::    .  ::   
NP_001 ALECAGFLAGIGLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQI
           170       180         190       200       210       220 

             290       300         310       320       330         
pF1KB4 TKKSDGKIDVSIEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIP
          . :.. :   : : .. :.:  .  .... :::   :...::: .:.... . :.::
NP_001 EAGTPGRLRVV--AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIP
             230         240       250       260       270         

      340       350       360        370        380       390      
pF1KB4 VNTRFQTKIPNIYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTH
       :. . ::..: ::::::..   . :.  : . : . .. . ::..:. ::. ::....: 
NP_001 VTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTP
     280       290       300       310       320       330         

        400           410        420       430       440       450 
pF1KB4 PEVAWVGKSEEQ----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVL
        : .  : :::.    . ::.:: :.   .:.  .  .. :    . . : . :...::.
NP_001 LEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVV
     340       350       360       370       380        390        

             460       470       480       490       500           
pF1KB4 GAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF  
       : :.:::.:::...  : ::. : . ...  .   ::. .:.:   ...   : ::    
NP_001 GFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAG
      400       410       420       430       440       450        

NP_001 CCG
      460 

>>NP_877393 (OMIM: 601112) thioredoxin reductase 1, cyto  (499 aa)
 initn: 574 init1: 133 opt: 601  Z-score: 744.3  bits: 147.2 E(85289): 1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:6-492)

         10        20        30          40        50        60    
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
                                     : :   : :. .::.: :: .:: .::: :
NP_877                          MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
                                        10        20        30     

           70                80        90       100       110      
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
        :.. ..            :::::.::::::.: :....    .:  .:  . : .. : 
NP_877 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
          40        50        60         70        80         90   

         120       130       140       150       160       170     
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
       :. . :.:.:  .. . .:. :    ....:::. :.::.. : ... ::.  :  .. .
NP_877 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
           100       110       120       130       140       150   

         180       190       200       210       220       230     
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
       .. .::::: :   . ::  :..  .::   .:.   : : .:.::. ...: ..    .
NP_877 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
           160        170       180       190       200       210  

         240       250       260       270          280       290  
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
       : :::..  .  .   :.:....... . ....:.::    .  ::      . :.. : 
NP_877 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
              220       230       240       250       260       270

            300         310       320       330        340         
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
         : : .. :.:  .  .... :::   :...::: .:.... . :.:::. . ::..: 
NP_877 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
                280       290       300       310       320        

     350       360        370        380       390       400       
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
       ::::::..   . :.  : . : . .. . ::..:. ::. ::....:  : .  : :::
NP_877 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
      330       340       350       360       370       380        

           410        420       430       440       450       460  
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
       .    . ::.:: :.   .:.  .  .. :    . . : . :...::.: :.:::.:::
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
      390       400       410       420        430       440       

            470       480       490       500              
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF     
       ...  : ::. : . ...  .   ::. .:.:   ...   : ::       
NP_877 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
       450       460       470       480       490         

>>NP_877420 (OMIM: 601112) thioredoxin reductase 1, cyto  (499 aa)
 initn: 574 init1: 133 opt: 601  Z-score: 744.3  bits: 147.2 E(85289): 1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:6-492)

         10        20        30          40        50        60    
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
                                     : :   : :. .::.: :: .:: .::: :
NP_877                          MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
                                        10        20        30     

           70                80        90       100       110      
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
        :.. ..            :::::.::::::.: :....    .:  .:  . : .. : 
NP_877 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
          40        50        60         70        80         90   

         120       130       140       150       160       170     
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
       :. . :.:.:  .. . .:. :    ....:::. :.::.. : ... ::.  :  .. .
NP_877 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
           100       110       120       130       140       150   

         180       190       200       210       220       230     
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
       .. .::::: :   . ::  :..  .::   .:.   : : .:.::. ...: ..    .
NP_877 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
           160        170       180       190       200       210  

         240       250       260       270          280       290  
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
       : :::..  .  .   :.:....... . ....:.::    .  ::      . :.. : 
NP_877 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
              220       230       240       250       260       270

            300         310       320       330        340         
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
         : : .. :.:  .  .... :::   :...::: .:.... . :.:::. . ::..: 
NP_877 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
                280       290       300       310       320        

     350       360        370        380       390       400       
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
       ::::::..   . :.  : . : . .. . ::..:. ::. ::....:  : .  : :::
NP_877 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
      330       340       350       360       370       380        

           410        420       430       440       450       460  
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
       .    . ::.:: :.   .:.  .  .. :    . . : . :...::.: :.:::.:::
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
      390       400       410       420        430       440       

            470       480       490       500              
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF     
       ...  : ::. : . ...  .   ::. .:.:   ...   : ::       
NP_877 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
       450       460       470       480       490         

>>NP_877419 (OMIM: 601112) thioredoxin reductase 1, cyto  (499 aa)
 initn: 574 init1: 133 opt: 601  Z-score: 744.3  bits: 147.2 E(85289): 1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:6-492)

         10        20        30          40        50        60    
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
                                     : :   : :. .::.: :: .:: .::: :
NP_877                          MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
                                        10        20        30     

           70                80        90       100       110      
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
        :.. ..            :::::.::::::.: :....    .:  .:  . : .. : 
NP_877 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
          40        50        60         70        80         90   

         120       130       140       150       160       170     
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
       :. . :.:.:  .. . .:. :    ....:::. :.::.. : ... ::.  :  .. .
NP_877 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
           100       110       120       130       140       150   

         180       190       200       210       220       230     
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
       .. .::::: :   . ::  :..  .::   .:.   : : .:.::. ...: ..    .
NP_877 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
           160        170       180       190       200       210  

         240       250       260       270          280       290  
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
       : :::..  .  .   :.:....... . ....:.::    .  ::      . :.. : 
NP_877 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
              220       230       240       250       260       270

            300         310       320       330        340         
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
         : : .. :.:  .  .... :::   :...::: .:.... . :.:::. . ::..: 
NP_877 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
                280       290       300       310       320        

     350       360        370        380       390       400       
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
       ::::::..   . :.  : . : . .. . ::..:. ::. ::....:  : .  : :::
NP_877 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
      330       340       350       360       370       380        

           410        420       430       440       450       460  
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
       .    . ::.:: :.   .:.  .  .. :    . . : . :...::.: :.:::.:::
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
      390       400       410       420        430       440       

            470       480       490       500              
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF     
       ...  : ::. : . ...  .   ::. .:.:   ...   : ::       
NP_877 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
       450       460       470       480       490         

>>NP_001248374 (OMIM: 601112) thioredoxin reductase 1, c  (549 aa)
 initn: 592 init1: 133 opt: 601  Z-score: 743.6  bits: 147.3 E(85289): 1.1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:56-542)

         10        20        30          40        50        60    
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
                                     : :   : :. .::.: :: .:: .::: :
NP_001 KQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
          30        40        50        60        70        80     

           70                80        90       100       110      
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
        :.. ..            :::::.::::::.: :....    .:  .:  . : .. : 
NP_001 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
          90       100       110        120       130        140   

         120       130       140       150       160       170     
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
       :. . :.:.:  .. . .:. :    ....:::. :.::.. : ... ::.  :  .. .
NP_001 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
           150       160       170       180       190       200   

         180       190       200       210       220       230     
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
       .. .::::: :   . ::  :..  .::   .:.   : : .:.::. ...: ..    .
NP_001 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
           210        220       230       240       250       260  

         240       250       260       270          280       290  
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
       : :::..  .  .   :.:....... . ....:.::    .  ::      . :.. : 
NP_001 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
              270       280       290       300       310       320

            300         310       320       330        340         
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
         : : .. :.:  .  .... :::   :...::: .:.... . :.:::. . ::..: 
NP_001 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
                330       340       350       360       370        

     350       360        370        380       390       400       
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
       ::::::..   . :.  : . : . .. . ::..:. ::. ::....:  : .  : :::
NP_001 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
      380       390       400       410       420       430        

           410        420       430       440       450       460  
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
       .    . ::.:: :.   .:.  .  .. :    . . : . :...::.: :.:::.:::
NP_001 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
      440       450       460       470        480       490       

            470       480       490       500              
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF     
       ...  : ::. : . ...  .   ::. .:.:   ...   : ::       
NP_001 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
       500       510       520       530       540         




509 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 06:10:03 2016 done: Sat Nov  5 06:10:04 2016
 Total Scan time:  8.680 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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