Result of FASTA (omim) for pF1KE0968
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0968, 520 aa
  1>>>pF1KE0968 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.3652+/-0.000681; mu= -5.4810+/- 0.041
 mean_var=633.3475+/-141.318, 0's: 0 Z-trim(114.1): 1105  B-trim: 33 in 1/55
 Lambda= 0.050963
 statistics sampled from 22334 (23837) to 22334 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.279), width:  16
 Scan time:  9.500

The best scores are:                                      opt bits E(85289)
NP_003836 (OMIM: 609181) dual specificity tyrosine ( 520) 3481 272.3 2.5e-72
NP_001269214 (OMIM: 609181) dual specificity tyros ( 234) 1596 133.2 8.6e-31
NP_001269215 (OMIM: 609181) dual specificity tyros ( 233) 1579 131.9   2e-30
NP_003574 (OMIM: 603496) dual specificity tyrosine ( 528) 1312 112.8 2.5e-24
XP_016875521 (OMIM: 603496) PREDICTED: dual specif ( 528) 1312 112.8 2.5e-24
NP_006473 (OMIM: 603496) dual specificity tyrosine ( 601) 1312 112.9 2.7e-24
XP_011508363 (OMIM: 603497) PREDICTED: dual specif ( 553) 1237 107.3 1.2e-22
XP_005273372 (OMIM: 603497) PREDICTED: dual specif ( 568) 1237 107.4 1.2e-22
NP_001004023 (OMIM: 603497) dual specificity tyros ( 568) 1237 107.4 1.2e-22
NP_003573 (OMIM: 603497) dual specificity tyrosine ( 588) 1237 107.4 1.2e-22
NP_006475 (OMIM: 604556,615812) dual specificity t ( 601)  982 88.7 5.5e-17
NP_006474 (OMIM: 604556,615812) dual specificity t ( 589)  943 85.8   4e-16
XP_005259455 (OMIM: 604556,615812) PREDICTED: dual ( 629)  935 85.2 6.2e-16
NP_004705 (OMIM: 604556,615812) dual specificity t ( 629)  935 85.2 6.2e-16
XP_011527787 (OMIM: 600855,614104) PREDICTED: dual ( 725)  934 85.3   7e-16
XP_016883774 (OMIM: 600855,614104) PREDICTED: dual ( 754)  934 85.3 7.1e-16
XP_016883773 (OMIM: 600855,614104) PREDICTED: dual ( 754)  934 85.3 7.1e-16
NP_569120 (OMIM: 600855,614104) dual specificity t ( 754)  934 85.3 7.1e-16
XP_006724042 (OMIM: 600855,614104) PREDICTED: dual ( 754)  934 85.3 7.1e-16
XP_011527786 (OMIM: 600855,614104) PREDICTED: dual ( 761)  934 85.3 7.2e-16
NP_569122 (OMIM: 600855,614104) dual specificity t ( 529)  927 84.5 8.4e-16
NP_567824 (OMIM: 600855,614104) dual specificity t ( 584)  927 84.6 8.9e-16
XP_016883775 (OMIM: 600855,614104) PREDICTED: dual ( 734)  927 84.7   1e-15
XP_006724041 (OMIM: 600855,614104) PREDICTED: dual ( 763)  927 84.8   1e-15
NP_001387 (OMIM: 600855,614104) dual specificity t ( 763)  927 84.8   1e-15
XP_006724040 (OMIM: 600855,614104) PREDICTED: dual ( 763)  927 84.8   1e-15
XP_006724039 (OMIM: 600855,614104) PREDICTED: dual ( 763)  927 84.8   1e-15
XP_011527785 (OMIM: 600855,614104) PREDICTED: dual ( 763)  927 84.8   1e-15
XP_011527784 (OMIM: 600855,614104) PREDICTED: dual ( 770)  927 84.8   1e-15
XP_016856095 (OMIM: 608003) PREDICTED: homeodomain ( 605)  697 67.7 1.1e-10
NP_689909 (OMIM: 608003) homeodomain-interacting p (1075)  697 68.1 1.5e-10
XP_016856094 (OMIM: 608003) PREDICTED: homeodomain (1209)  697 68.2 1.6e-10
NP_938009 (OMIM: 608003) homeodomain-interacting p (1210)  697 68.2 1.6e-10
XP_005270670 (OMIM: 608003) PREDICTED: homeodomain (1210)  697 68.2 1.6e-10
XP_005270669 (OMIM: 608003) PREDICTED: homeodomain (1210)  697 68.2 1.6e-10
XP_006710506 (OMIM: 608003) PREDICTED: homeodomain (1247)  697 68.2 1.6e-10
XP_005270668 (OMIM: 608003) PREDICTED: homeodomain (1256)  697 68.2 1.6e-10
XP_005270667 (OMIM: 608003) PREDICTED: homeodomain (1280)  697 68.2 1.7e-10
XP_005270666 (OMIM: 608003) PREDICTED: homeodomain (1281)  697 68.2 1.7e-10
NP_001106710 (OMIM: 606868) homeodomain-interactin (1171)  695 68.0 1.8e-10
XP_016867558 (OMIM: 606868) PREDICTED: homeodomain (1191)  695 68.0 1.8e-10
XP_006715998 (OMIM: 606868) PREDICTED: homeodomain (1191)  695 68.0 1.8e-10
NP_073577 (OMIM: 606868) homeodomain-interacting p (1198)  695 68.0 1.8e-10
XP_011514383 (OMIM: 606868) PREDICTED: homeodomain (1206)  695 68.0 1.8e-10
XP_011514382 (OMIM: 606868) PREDICTED: homeodomain (1349)  695 68.1 1.9e-10
XP_011514381 (OMIM: 606868) PREDICTED: homeodomain (1350)  695 68.1 1.9e-10
XP_011514380 (OMIM: 606868) PREDICTED: homeodomain (1376)  695 68.1 1.9e-10
XP_011514379 (OMIM: 606868) PREDICTED: homeodomain (1377)  695 68.1 1.9e-10
XP_005260990 (OMIM: 600855,614104) PREDICTED: dual ( 535)  683 66.6 2.1e-10
XP_016872566 (OMIM: 604424) PREDICTED: homeodomain (1194)  681 67.0 3.6e-10


>>NP_003836 (OMIM: 609181) dual specificity tyrosine-pho  (520 aa)
 initn: 3481 init1: 3481 opt: 3481  Z-score: 1419.6  bits: 272.3 E(85289): 2.5e-72
Smith-Waterman score: 3481; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)

               10        20        30        40        50        60
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
              430       440       450       460       470       480

              490       500       510       520
pF1KE0 QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
       ::::::::::::::::::::::::::::::::::::::::
NP_003 QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
              490       500       510       520

>>NP_001269214 (OMIM: 609181) dual specificity tyrosine-  (234 aa)
 initn: 1596 init1: 1596 opt: 1596  Z-score: 673.8  bits: 133.2 E(85289): 8.6e-31
Smith-Waterman score: 1596; 100.0% identity (100.0% similar) in 234 aa overlap (287-520:1-234)

        260       270       280       290       300       310      
pF1KE0 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI
                                     ::::::::::::::::::::::::::::::
NP_001                               MWSLGCITAELYTGYPLFPGENEVEQLACI
                                             10        20        30

        320       330       340       350       360       370      
pF1KE0 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
               40        50        60        70        80        90

        380       390       400       410       420       430      
pF1KE0 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
              100       110       120       130       140       150

        440       450       460       470       480       490      
pF1KE0 SSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
              160       170       180       190       200       210

        500       510       520
pF1KE0 VSMTSPGQSKNFSLKNTNVLPPIV
       ::::::::::::::::::::::::
NP_001 VSMTSPGQSKNFSLKNTNVLPPIV
              220       230    

>>NP_001269215 (OMIM: 609181) dual specificity tyrosine-  (233 aa)
 initn: 1075 init1: 1075 opt: 1579  Z-score: 667.1  bits: 131.9 E(85289): 2e-30
Smith-Waterman score: 1579; 99.6% identity (99.6% similar) in 234 aa overlap (287-520:1-233)

        260       270       280       290       300       310      
pF1KE0 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI
                                     ::::::::::::::::::::::::::::::
NP_001                               MWSLGCITAELYTGYPLFPGENEVEQLACI
                                             10        20        30

        320       330       340       350       360       370      
pF1KE0 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
               40        50        60        70        80        90

        380       390       400       410       420       430      
pF1KE0 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
              100       110       120       130       140       150

        440       450       460       470       480       490      
pF1KE0 SSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
       :::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSRK-DEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
               160       170       180       190       200         

        500       510       520
pF1KE0 VSMTSPGQSKNFSLKNTNVLPPIV
       ::::::::::::::::::::::::
NP_001 VSMTSPGQSKNFSLKNTNVLPPIV
     210       220       230   

>>NP_003574 (OMIM: 603496) dual specificity tyrosine-pho  (528 aa)
 initn: 1450 init1: 1307 opt: 1312  Z-score: 557.6  bits: 112.8 E(85289): 2.5e-24
Smith-Waterman score: 1467; 53.4% identity (77.8% similar) in 414 aa overlap (23-419:68-476)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :. :   : . . .:  .:.: . ..:. .
NP_003 LTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAF
        40        50        60        70        80        90       

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..::::.::: .      .. ..::..: :..: :::.:::::::..:::
NP_003 EHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK
       100       110       120       130       140       150       

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       ::::::.:  ::: .. ::::..::.::::.::  :..::: :::.:::::.::.:: . 
NP_003 GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLEN
       160       170       180       190       200       210       

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : ::::.:.:::::..:::::.:.:.:::::: .::.:. :.:.::. :  ..:::::::
NP_003 FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLK
       220       230       240       250       260       270       

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: :.:....:::::::::::::.:::::::::::.::::::  : . ::::::::
NP_003 PENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGC
       280       290       300       310       320       330       

            300       310       320       330       340            
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT----
       : ::: :::::.:::.: .::::..:.::.:   ......: ..: .:::.:.  :    
NP_003 ILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTL
       340       350       360       370       380       390       

                 350        360       370        380       390     
pF1KE0 -----------NNRGKKRYP-DSKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                  . ::: : : .:..   .::  :   :::::..:: :.:..:::: :::
NP_003 SDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL
       400       410       420       430       440       450       

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :..  : :   :.: : .:..                                    
NP_003 RHPWLR--RRL---PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTD
       460            470       480       490       500       510  

>>XP_016875521 (OMIM: 603496) PREDICTED: dual specificit  (528 aa)
 initn: 1450 init1: 1307 opt: 1312  Z-score: 557.6  bits: 112.8 E(85289): 2.5e-24
Smith-Waterman score: 1467; 53.4% identity (77.8% similar) in 414 aa overlap (23-419:68-476)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :. :   : . . .:  .:.: . ..:. .
XP_016 LTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAF
        40        50        60        70        80        90       

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..::::.::: .      .. ..::..: :..: :::.:::::::..:::
XP_016 EHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK
       100       110       120       130       140       150       

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       ::::::.:  ::: .. ::::..::.::::.::  :..::: :::.:::::.::.:: . 
XP_016 GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLEN
       160       170       180       190       200       210       

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : ::::.:.:::::..:::::.:.:.:::::: .::.:. :.:.::. :  ..:::::::
XP_016 FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLK
       220       230       240       250       260       270       

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: :.:....:::::::::::::.:::::::::::.::::::  : . ::::::::
XP_016 PENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGC
       280       290       300       310       320       330       

            300       310       320       330       340            
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT----
       : ::: :::::.:::.: .::::..:.::.:   ......: ..: .:::.:.  :    
XP_016 ILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTL
       340       350       360       370       380       390       

                 350        360       370        380       390     
pF1KE0 -----------NNRGKKRYP-DSKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                  . ::: : : .:..   .::  :   :::::..:: :.:..:::: :::
XP_016 SDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL
       400       410       420       430       440       450       

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :..  : :   :.: : .:..                                    
XP_016 RHPWLR--RRL---PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTD
       460            470       480       490       500       510  

>>NP_006473 (OMIM: 603496) dual specificity tyrosine-pho  (601 aa)
 initn: 1450 init1: 1307 opt: 1312  Z-score: 557.1  bits: 112.9 E(85289): 2.7e-24
Smith-Waterman score: 1467; 53.4% identity (77.8% similar) in 414 aa overlap (23-419:141-549)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :. :   : . . .:  .:.: . ..:. .
NP_006 LTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAF
              120       130       140       150       160       170

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..::::.::: .      .. ..::..: :..: :::.:::::::..:::
NP_006 EHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK
              180       190       200       210       220       230

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       ::::::.:  ::: .. ::::..::.::::.::  :..::: :::.:::::.::.:: . 
NP_006 GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLEN
              240       250       260       270       280       290

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : ::::.:.:::::..:::::.:.:.:::::: .::.:. :.:.::. :  ..:::::::
NP_006 FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLK
              300       310       320       330       340       350

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: :.:....:::::::::::::.:::::::::::.::::::  : . ::::::::
NP_006 PENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGC
              360       370       380       390       400       410

            300       310       320       330       340            
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT----
       : ::: :::::.:::.: .::::..:.::.:   ......: ..: .:::.:.  :    
NP_006 ILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTL
              420       430       440       450       460       470

                 350        360       370        380       390     
pF1KE0 -----------NNRGKKRYP-DSKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                  . ::: : : .:..   .::  :   :::::..:: :.:..:::: :::
NP_006 SDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL
              480       490       500       510       520       530

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :..  : :   :.: : .:..                                    
NP_006 RHPWLR--RRL---PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTD
                   540       550       560       570       580     

>>XP_011508363 (OMIM: 603497) PREDICTED: dual specificit  (553 aa)
 initn: 1395 init1: 1237 opt: 1237  Z-score: 527.6  bits: 107.3 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:93-496)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :.. .:   . : ::  .::: .:..:. :
XP_011 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
             70        80        90       100       110       120  

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..:.: .:::   .    .. ..::  : :..: .::.:::::::. :::
XP_011 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
            130       140       150       160       170       180  

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       :::::::.  :::  . ::::..::.::::.::  :..::: :.:.:: ...::.:: . 
XP_011 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
            190       200       210       220       230       240  

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. :  .::::::::
XP_011 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
            250       260       270       280       290       300  

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: ..:..:.:::::::::.:.::.::::::::::.::.:::  :.. ::.::.::
XP_011 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
            310       320       330       340       350       360  

            300       310       320       330       340         350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
       : ::: :: ::::::.: .::::.::.::.::  ... ..: . :..:::.:.  ..:..
XP_011 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
            370       380       390       400       410       420  

                            360       370        380       390     
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                    ::::: :  :::   .::  :   :..::.::: :.:: :.:: :::
XP_011 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
            430       440       450       460       470       480  

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :: .:      ::: :                                         
XP_011 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
            490            500       510       520       530       

>>XP_005273372 (OMIM: 603497) PREDICTED: dual specificit  (568 aa)
 initn: 1395 init1: 1237 opt: 1237  Z-score: 527.5  bits: 107.4 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:108-511)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :.. .:   . : ::  .::: .:..:. :
XP_005 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
        80        90       100       110       120       130       

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..:.: .:::   .    .. ..::  : :..: .::.:::::::. :::
XP_005 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
       140       150       160       170       180       190       

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       :::::::.  :::  . ::::..::.::::.::  :..::: :.:.:: ...::.:: . 
XP_005 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
       200       210       220       230       240       250       

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. :  .::::::::
XP_005 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
       260       270       280       290       300       310       

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: ..:..:.:::::::::.:.::.::::::::::.::.:::  :.. ::.::.::
XP_005 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
       320       330       340       350       360       370       

            300       310       320       330       340         350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
       : ::: :: ::::::.: .::::.::.::.::  ... ..: . :..:::.:.  ..:..
XP_005 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
       380       390       400       410       420       430       

                            360       370        380       390     
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                    ::::: :  :::   .::  :   :..::.::: :.:: :.:: :::
XP_005 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
       440       450       460       470       480       490       

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :: .:      ::: :                                         
XP_005 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
       500            510       520       530       540       550  

>>NP_001004023 (OMIM: 603497) dual specificity tyrosine-  (568 aa)
 initn: 1395 init1: 1237 opt: 1237  Z-score: 527.5  bits: 107.4 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:108-511)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :.. .:   . : ::  .::: .:..:. :
NP_001 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
        80        90       100       110       120       130       

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..:.: .:::   .    .. ..::  : :..: .::.:::::::. :::
NP_001 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
       140       150       160       170       180       190       

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       :::::::.  :::  . ::::..::.::::.::  :..::: :.:.:: ...::.:: . 
NP_001 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
       200       210       220       230       240       250       

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. :  .::::::::
NP_001 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
       260       270       280       290       300       310       

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: ..:..:.:::::::::.:.::.::::::::::.::.:::  :.. ::.::.::
NP_001 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
       320       330       340       350       360       370       

            300       310       320       330       340         350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
       : ::: :: ::::::.: .::::.::.::.::  ... ..: . :..:::.:.  ..:..
NP_001 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
       380       390       400       410       420       430       

                            360       370        380       390     
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                    ::::: :  :::   .::  :   :..::.::: :.:: :.:: :::
NP_001 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
       440       450       460       470       480       490       

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :: .:      ::: :                                         
NP_001 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
       500            510       520       530       540       550  

>>NP_003573 (OMIM: 603497) dual specificity tyrosine-pho  (588 aa)
 initn: 1395 init1: 1237 opt: 1237  Z-score: 527.4  bits: 107.4 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:128-531)

                       10        20        30        40        50  
pF1KE0         MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
                                     :.. .:   . : ::  .::: .:..:. :
NP_003 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
       100       110       120       130       140       150       

             60        70        80        90       100       110  
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
       :. ::..: :..:.: .:::   .    .. ..::  : :..: .::.:::::::. :::
NP_003 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
       160       170       180       190       200       210       

            120       130       140       150       160       170  
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
       :::::::.  :::  . ::::..::.::::.::  :..::: :.:.:: ...::.:: . 
NP_003 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
       220       230       240       250       260       270       

            180       190       200       210       220       230  
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
       : :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. :  .::::::::
NP_003 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
       280       290       300       310       320       330       

            240       250       260       270       280       290  
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
       ::::.: ..:..:.:::::::::.:.::.::::::::::.::.:::  :.. ::.::.::
NP_003 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
       340       350       360       370       380       390       

            300       310       320       330       340         350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
       : ::: :: ::::::.: .::::.::.::.::  ... ..: . :..:::.:.  ..:..
NP_003 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
       400       410       420       430       440       450       

                            360       370        380       390     
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
                    ::::: :  :::   .::  :   :..::.::: :.:: :.:: :::
NP_003 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
       460       470       480       490       500       510       

         400       410       420       430       440       450     
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
       .: :: .:      ::: :                                         
NP_003 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
       520            530       540       550       560       570  




520 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 04:45:45 2016 done: Sat Nov  5 04:45:47 2016
 Total Scan time:  9.500 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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