Result of FASTA (omim) for pF1KE0266
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0266, 450 aa
  1>>>pF1KE0266 450 - 450 aa - 450 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.7781+/-0.00032; mu= 12.1788+/- 0.020
 mean_var=119.3758+/-23.912, 0's: 0 Z-trim(119.6): 160  B-trim: 0 in 0/55
 Lambda= 0.117386
 statistics sampled from 33577 (33760) to 33577 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.396), width:  16
 Scan time: 10.700

The best scores are:                                      opt bits E(85289)
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 3067 530.1 4.5e-150
XP_011518536 (OMIM: 606372) PREDICTED: neuronal ac ( 244) 1664 292.3 9.3e-79
NP_001289964 (OMIM: 606372) neuronal acetylcholine ( 244) 1664 292.3 9.3e-79
NP_001289963 (OMIM: 606372) neuronal acetylcholine ( 244) 1664 292.3 9.3e-79
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 1560 274.9 3.2e-73
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1074 192.6   2e-48
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1074 192.7 2.1e-48
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1015 182.6 1.9e-45
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1014 182.5 2.2e-45
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1014 182.5 2.3e-45
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1004 180.8 6.9e-45
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494)  997 179.6 1.6e-44
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529)  989 178.3 4.4e-44
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529)  989 178.3 4.4e-44
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529)  989 178.3 4.4e-44
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380)  976 176.0 1.6e-43
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458)  967 174.5 5.2e-43
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627)  968 174.8   6e-43
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486)  965 174.2 6.9e-43
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449)  953 172.1 2.7e-42
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462)  953 172.1 2.7e-42
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463)  953 172.1 2.7e-42
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498)  953 172.1 2.9e-42
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495)  932 168.6 3.4e-41
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495)  932 168.6 3.4e-41
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468)  924 167.2 8.3e-41
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468)  924 167.2 8.3e-41
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438)  917 166.0 1.8e-40
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514)  909 164.7 5.2e-40
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502)  907 164.4 6.4e-40
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468)  899 163.0 1.6e-39
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482)  871 158.2 4.3e-38
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489)  871 158.3 4.3e-38
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546)  854 155.4 3.5e-37
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479)  847 154.2 7.1e-37
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424)  827 150.8 6.7e-36
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424)  827 150.8 6.7e-36
NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 484)  776 142.2   3e-33
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463)  771 141.3 5.2e-33
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401)  754 138.4 3.4e-32
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412)  750 137.7 5.5e-32
NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412)  750 137.7 5.5e-32
XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440)  750 137.7 5.8e-32
XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441)  750 137.7 5.9e-32
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370)  660 122.4   2e-27
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370)  660 122.4   2e-27
XP_011520457 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 290)  653 121.2 3.7e-27
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556)  640 119.2 2.9e-26
NP_998786 (OMIM: 182139) 5-hydroxytryptamine recep ( 516)  637 118.6 3.8e-26
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329)  627 116.8 8.6e-26


>>NP_065135 (OMIM: 606372) neuronal acetylcholine recept  (450 aa)
 initn: 3067 init1: 3067 opt: 3067  Z-score: 2815.3  bits: 530.1 E(85289): 4.5e-150
Smith-Waterman score: 3067; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)

               10        20        30        40        50        60
pF1KE0 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
              370       380       390       400       410       420

              430       440       450
pF1KE0 RLARVMDRFFLAIFFSMALVMSLLVLVQAL
       ::::::::::::::::::::::::::::::
NP_065 RLARVMDRFFLAIFFSMALVMSLLVLVQAL
              430       440       450

>>XP_011518536 (OMIM: 606372) PREDICTED: neuronal acetyl  (244 aa)
 initn: 1664 init1: 1664 opt: 1664  Z-score: 1535.0  bits: 292.3 E(85289): 9.3e-79
Smith-Waterman score: 1664; 100.0% identity (100.0% similar) in 244 aa overlap (207-450:1-244)

        180       190       200       210       220       230      
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA
                                     ::::::::::::::::::::::::::::::
XP_011                               MPARRRVLTYGCCSEPYPDVTFTLLLRRRA
                                             10        20        30

        240       250       260       270       280       290      
pF1KE0 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
               40        50        60        70        80        90

        300       310       320       330       340       350      
pF1KE0 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
              100       110       120       130       140       150

        360       370       380       390       400       410      
pF1KE0 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
              160       170       180       190       200       210

        420       430       440       450
pF1KE0 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
       ::::::::::::::::::::::::::::::::::
XP_011 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
              220       230       240    

>>NP_001289964 (OMIM: 606372) neuronal acetylcholine rec  (244 aa)
 initn: 1664 init1: 1664 opt: 1664  Z-score: 1535.0  bits: 292.3 E(85289): 9.3e-79
Smith-Waterman score: 1664; 100.0% identity (100.0% similar) in 244 aa overlap (207-450:1-244)

        180       190       200       210       220       230      
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA
                                     ::::::::::::::::::::::::::::::
NP_001                               MPARRRVLTYGCCSEPYPDVTFTLLLRRRA
                                             10        20        30

        240       250       260       270       280       290      
pF1KE0 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
               40        50        60        70        80        90

        300       310       320       330       340       350      
pF1KE0 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
              100       110       120       130       140       150

        360       370       380       390       400       410      
pF1KE0 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
              160       170       180       190       200       210

        420       430       440       450
pF1KE0 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
       ::::::::::::::::::::::::::::::::::
NP_001 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
              220       230       240    

>>NP_001289963 (OMIM: 606372) neuronal acetylcholine rec  (244 aa)
 initn: 1664 init1: 1664 opt: 1664  Z-score: 1535.0  bits: 292.3 E(85289): 9.3e-79
Smith-Waterman score: 1664; 100.0% identity (100.0% similar) in 244 aa overlap (207-450:1-244)

        180       190       200       210       220       230      
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA
                                     ::::::::::::::::::::::::::::::
NP_001                               MPARRRVLTYGCCSEPYPDVTFTLLLRRRA
                                             10        20        30

        240       250       260       270       280       290      
pF1KE0 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVP
               40        50        60        70        80        90

        300       310       320       330       340       350      
pF1KE0 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEP
              100       110       120       130       140       150

        360       370       380       390       400       410      
pF1KE0 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCH
              160       170       180       190       200       210

        420       430       440       450
pF1KE0 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
       ::::::::::::::::::::::::::::::::::
NP_001 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
              220       230       240    

>>NP_060051 (OMIM: 605116) neuronal acetylcholine recept  (479 aa)
 initn: 1707 init1: 1540 opt: 1560  Z-score: 1435.6  bits: 274.9 E(85289): 3.2e-73
Smith-Waterman score: 1668; 55.4% identity (77.5% similar) in 453 aa overlap (25-449:26-478)

                10        20        30        40        50         
pF1KE0  MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTL
                                :.:. : ::: ::: .:..::::: :::..:::::
NP_060 MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KE0 EVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLY
       ..::::: :::::::.:: :::::: : :::: :: . : :::.:::::.::::::::::
NP_060 QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KE0 NKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGG
       :::: .    ..::::::.:: . :::::::.::: :::. :::: :.:.:::::::..:
NP_060 NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KE0 HQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAY
       .:.:.     ...:.::.:.:::.: :::: . :..:::::::::::::::::.::.. :
NP_060 NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
              190       200       210       220       230       240

     240       250       260       270       280       290         
pF1KE0 VCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIG
       . :::.::::::.::::.:.::: ::::::::::.:::.:::::..:: :: .:.:::::
NP_060 IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
              250       260       270       280       290       300

     300       310       320       330       340       350         
pF1KE0 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPC--
       :::.:::...: ::::::..::.:.::  .:::: :::...: ...: : : . :: :  
NP_060 KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
              310       320       330       340       350       360

        360            370                          380       390  
pF1KE0 -GQSRPPE-----LSPSPQSPEGGA-------------------GPPAGPCHEPRCLCRQ
         .::  .      :  :.:   .:                   :  .   .: .  : :
NP_060 PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
              370       380       390       400       410       420

             400       410       420       430       440       450
pF1KE0 -EALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
        ..: ...  ::. ...:.:..    .::..:.:.::::. ::: :..::..:....: 
NP_060 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
              430       440       450       460       470         

>>NP_000737 (OMIM: 118511,612001) neuronal acetylcholine  (502 aa)
 initn: 758 init1: 536 opt: 1074  Z-score: 990.5  bits: 192.6 E(85289): 2e-48
Smith-Waterman score: 1079; 40.6% identity (65.1% similar) in 456 aa overlap (26-434:22-475)

               10        20        30        40        50        60
pF1KE0 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
                                .:..  ::...:  ::.   ::::. .: :.: . 
NP_000     MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFS
                   10        20        30        40        50      

               70        80        90       100       110       120
pF1KE0 VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
       ..: ::.:.::.:::::  .:... ::: ::.:. . : :. ..:.:.. .:.:::.:::
NP_000 LSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYN
         60        70        80        90       100       110      

              130       140       150       160       170       180
pF1KE0 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
       .:: .  ..  :::..  .:  ..  :.: .::: .::  ::::.::: : ::::..:: 
NP_000 SADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGW
        120       130       140       150       160       170      

              190       200       210       220       230       240
pF1KE0 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
       .::.. .   :... .. : :: ..:.:..:    : ::.:::::::::. .:::.  : 
NP_000 SLDLQMQ--EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYG
        180         190       200       210       220       230    

              250       260       270       280       290          
pF1KE0 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP-AESVPLIG
        :::.:::::: :: :.: ::::::::.:::.::::.::::.::.:: ::  ..:::::.
NP_000 LNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIA
          240       250       260       270       280       290    

     300       310       320       330       340       350         
pF1KE0 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE----
       .:. .:: .: .:...:..... :.  :.   .: :.:..::.  :  : ... ::    
NP_000 QYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVR
          300       310       320       330       340       350    

         360                 370                     380           
pF1KE0 PCGQSRPP-------ELS---PSPQSP--------EGGAG------PPAGP-CHEPRCL-
       :  : .         :.:   : : :         .:  :      : .:  : .  :  
NP_000 PACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSP
          360       370       380       390       400       410    

     390                       400       410       420       430   
pF1KE0 CRQEALLH----------------HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAI
        ..: :::                .:  ::: :: .  ..    .::  : :.::. :  
NP_000 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA
          420       430       440       450       460       470    

           440       450           
pF1KE0 FFSMALVMSLLVLVQAL           
       :                           
NP_000 FSVFTIICTIGILMSAPNFVEAVSKDFA
          480       490       500  

>>NP_001177384 (OMIM: 118511,612001) neuronal acetylchol  (531 aa)
 initn: 758 init1: 536 opt: 1074  Z-score: 990.1  bits: 192.7 E(85289): 2.1e-48
Smith-Waterman score: 1079; 40.6% identity (65.1% similar) in 456 aa overlap (26-434:51-504)

                    10        20        30        40        50     
pF1KE0      MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTL
                                     .:..  ::...:  ::.   ::::. .: :
NP_001 ATASPPSTPPWDPGHIPGASVRPAPGPVSLQGEFQRKLYKELVKNYNPLERPVANDSQPL
               30        40        50        60        70        80

          60        70        80        90       100       110     
pF1KE0 NVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPD
       .: . ..: ::.:.::.:::::  .:... ::: ::.:. . : :. ..:.:.. .:.::
NP_001 TVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPD
               90       100       110       120       130       140

         120       130       140       150       160       170     
pF1KE0 IVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSW
       :.:::.:: .  ..  :::..  .:  ..  :.: .::: .::  ::::.::: : ::::
NP_001 ILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSW
              150       160       170       180       190       200

         180       190       200       210       220       230     
pF1KE0 THGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRR
       ..:: .::.. .   :... .. : :: ..:.:..:    : ::.:::::::::. .:::
NP_001 SYGGWSLDLQMQ--EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRR
              210         220       230       240       250        

         240       250       260       270       280       290     
pF1KE0 AAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP-AES
       .  :  :::.:::::: :: :.: ::::::::.:::.::::.::::.::.:: ::  ..:
NP_001 TLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDS
      260       270       280       290       300       310        

          300       310       320       330       340       350    
pF1KE0 VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERG
       ::::..:. .:: .: .:...:..... :.  :.   .: :.:..::.  :  : ... :
NP_001 VPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG
      320       330       340       350       360       370        

              360                 370                     380      
pF1KE0 E----PCGQSRPP-------ELS---PSPQSP--------EGGAG------PPAGP-CHE
       :    :  : .         :.:   : : :         .:  :      : .:  : .
NP_001 EDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR
      380       390       400       410       420       430        

          390                       400       410       420        
pF1KE0 PRCL-CRQEALLH----------------HVATIANTFRSHRAAQRCHEDWKRLARVMDR
         :   ..: :::                .:  ::: :: .  ..    .::  : :.::
NP_001 MACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR
      440       450       460       470       480       490        

      430       440       450           
pF1KE0 FFLAIFFSMALVMSLLVLVQAL           
       . :  :                           
NP_001 LCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
      500       510       520       530 

>>NP_000070 (OMIM: 100690,253290,601462,608930) acetylch  (457 aa)
 initn: 1005 init1: 569 opt: 1015  Z-score: 937.1  bits: 182.6 E(85289): 1.9e-45
Smith-Waterman score: 1015; 35.5% identity (68.1% similar) in 451 aa overlap (12-450:6-450)

               10        20            30        40        50      
pF1KE0 MGLRSHHLSLGLLLLFLLPAE--CLGAEG--RLALKLFRDLFANYTSALRPVADTDQTLN
                  ::::: : .    ::.:   ::. :::.:    :.:..::: :  :...
NP_000       MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKD----YSSVVRPVEDHRQVVE
                     10        20        30            40        50

         60        70        80        90       100       110      
pF1KE0 VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDI
       ::. . : :.:..:: ::..:  . ..:.:.:  :.:.:. :::.  :.:::  .::::.
NP_000 VTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDL
               60        70        80        90       100       110

        120       130       140       150       160       170      
pF1KE0 VLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWT
       ::::.::..      :.:.:.. : . :  ::: .: :.. :. :::: :.:.. .:.::
NP_000 VLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWT
              120       130       140       150       160       170

        180       190       200       210       220        230     
pF1KE0 HGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSE-PYPDVTFTLLLRRR
       . :  . . :..   .:..:.:. :: .    . .. .::.:: . :: :.:. ....: 
NP_000 YDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRL
              180       190       200       210       220       230

         240       250       260       270       280       290     
pF1KE0 AAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAES-
          .. :...::.:.:.:. :.:.::.:::::..:...:::.:::: :...: .: . : 
NP_000 PLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSA
              240       250       260       270       280       290

          300       310       320       330       340       350    
pF1KE0 VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERG
       :::::::.. ::..:  :  .:....: :. .::.. .: :.: ...  .   .      
NP_000 VPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMK
              300       310       320       330       340       350

          360          370       380       390          400        
pF1KE0 EPCGQSRPPELSPSP---QSPEGGAGPPAGPCHEPRCLCRQ---EALLHHVATIANTFRS
       .:  ...  ..       ..  :  :::    : :  : ..   .. .. .  ::.:..:
NP_000 RPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSP--LIKHPEVKSAIEGIKYIAETMKS
              360       370       380         390       400        

      410       420       430       440       450       
pF1KE0 HRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL       
        . ..    .:: .: :::...:..:. . .. .: :..  :       
NP_000 DQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
      410       420       430       440       450       

>>NP_001160166 (OMIM: 118503,612052) neuronal acetylchol  (489 aa)
 initn: 1013 init1: 858 opt: 1014  Z-score: 935.7  bits: 182.5 E(85289): 2.2e-45
Smith-Waterman score: 1018; 39.3% identity (70.3% similar) in 394 aa overlap (10-392:18-407)

                       10         20        30        40        50 
pF1KE0         MGLRSHHLSLGLLLLFLLP-AECLGAEGRLALKLFRDLFANYTSALRPVADT
                        : :::: ::: :.   :: :    ::. :: .:.  .::::..
NP_001 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHR----LFERLFEDYNEIIRPVANV
               10        20        30            40        50      

              60        70        80        90       100       110 
pF1KE0 DQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLV
       .. . . .::..::.. .:: ::..   ::..: :.:  :.:.:. ::: . .:.:.. .
NP_001 SDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKI
         60        70        80        90       100       110      

             120       130       140       150       160       170 
pF1KE0 WRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLT
       :.:::::::.: ..   . .:...:.. : : :  ::: .:::..::. :::: :.: . 
NP_001 WKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMK
        120       130       140       150       160       170      

             180       190       200       210       220       230 
pF1KE0 FGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLL
       ::::..   ..:.   :.. .: :. :. :: ..  :. .. . :.:: : :::.:..: 
NP_001 FGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLY
        180       190       200       210       220       230      

             240       250       260       270       280       290 
pF1KE0 LRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP
       .::    :. ::..::.:::.:. :.:.::.: ::::.: ..:::.:::: :...:..: 
NP_001 IRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPS
        240       250       260       270       280       290      

              300       310       320       330       340       350
pF1KE0 AESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV
       .  : ::::.: . :: .::.: ..:....:.::  :... .:.:.....:. : : . .
NP_001 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFM
        300       310       320       330       340       350      

              360              370       380         390       400 
pF1KE0 RERGEPCGQSRPP------ELSP-SPQSPEGGAGPPAG-PCHEPRC-LCRQEALLHHVAT
        .     :... :      :::  .  :   . :   : ::..  :  :..         
NP_001 TRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFS
        360       370       380       390       400       410      

             410       420       430       440       450           
pF1KE0 IANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL           
                                                                   
NP_001 ANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEEQKAQEIQQLKRK
        420       430       440       450       460       470      

>>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine  (505 aa)
 initn: 1096 init1: 858 opt: 1014  Z-score: 935.5  bits: 182.5 E(85289): 2.3e-45
Smith-Waterman score: 1045; 36.8% identity (65.7% similar) in 470 aa overlap (10-434:18-483)

                       10         20        30        40        50 
pF1KE0         MGLRSHHLSLGLLLLFLLP-AECLGAEGRLALKLFRDLFANYTSALRPVADT
                        : :::: ::: :.   :: ::    :. :: .:.  .::::..
NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRL----FERLFEDYNEIIRPVANV
               10        20        30            40        50      

              60        70        80        90       100       110 
pF1KE0 DQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLV
       .. . . .::..::.. .:: ::..   ::..: :.:  :.:.:. ::: . .:.:.. .
NP_000 SDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKI
         60        70        80        90       100       110      

             120       130       140       150       160       170 
pF1KE0 WRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLT
       :.:::::::.: ..   . .:...:.. : : :  ::: .:::..::. :::: :.: . 
NP_000 WKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMK
        120       130       140       150       160       170      

             180       190       200       210       220       230 
pF1KE0 FGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLL
       ::::..   ..:.   :.. .: :. :. :: ..  :. .. . :.:: : :::.:..: 
NP_000 FGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLY
        180       190       200       210       220       230      

             240       250       260       270       280       290 
pF1KE0 LRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP
       .::    :. ::..::.:::.:. :.:.::.: ::::.: ..:::.:::: :...:..: 
NP_000 IRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPS
        240       250       260       270       280       290      

              300       310       320       330       340       350
pF1KE0 AESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV
       .  : ::::.: . :: .::.: ..:....:.::  :... .:.:.....:. : : . .
NP_000 TSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFM
        300       310       320       330       340       350      

              360                  370       380                   
pF1KE0 RERGEPCGQSRPP------ELS-----PSPQSPEGGAGPPA-----GPCHEPRC------
        .     :... :      :::        .:     : :      : ::. :       
NP_000 TRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFS
        360       370       380       390       400       410      

        390                          400       410       420       
pF1KE0 --LCRQ------EALL-------------HHVATIANTFRSHRAAQRCHEDWKRLARVMD
         : :.      .:.:             . :  ::......  :.. ..::: .: :.:
NP_000 ANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVID
        420       430       440       450       460       470      

       430       440       450      
pF1KE0 RFFLAIFFSMALVMSLLVLVQAL      
       :.:: .:                      
NP_000 RIFLWVFTLVCILGTAGLFLQPLMAREDA
        480       490       500     




450 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 18:19:44 2016 done: Thu Nov  3 18:19:46 2016
 Total Scan time: 10.700 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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