Result of FASTA (omim) for pF1KE0245
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0245, 240 aa
  1>>>pF1KE0245 240 - 240 aa - 240 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.3718+/-0.000299; mu= 19.3048+/- 0.019
 mean_var=59.6811+/-12.109, 0's: 0 Z-trim(116.3): 27  B-trim: 0 in 0/52
 Lambda= 0.166018
 statistics sampled from 27279 (27306) to 27279 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.32), width:  16
 Scan time:  7.120

The best scores are:                                      opt bits E(85289)
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 1611 393.8 1.4e-109
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 1611 393.8 1.4e-109
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 1126 277.6 1.2e-74
XP_016882907 (OMIM: 604520) PREDICTED: tumor necro ( 128)  672 168.6 4.5e-42
NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281)  295 78.6 1.2e-14
NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233)  234 64.0 2.7e-10
NP_001191273 (OMIM: 604052) tumor necrosis factor  ( 192)  222 61.0 1.7e-09
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251)  222 61.1 2.1e-09
NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281)  189 53.3 5.3e-07
XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244)  179 50.8 2.5e-06
XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244)  179 50.8 2.5e-06
NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244)  179 50.8 2.5e-06
XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263)  179 50.8 2.7e-06
NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317)  179 50.9 3.1e-06
XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205)  170 48.6   1e-05
XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205)  170 48.6   1e-05
NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205)  170 48.6   1e-05
NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205)  170 48.6   1e-05
XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205)  170 48.6   1e-05
XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205)  170 48.6   1e-05
NP_003802 (OMIM: 606182) tumor necrosis factor lig ( 254)  162 46.8 4.4e-05


>>XP_016882906 (OMIM: 604520) PREDICTED: tumor necrosis   (240 aa)
 initn: 1611 init1: 1611 opt: 1611  Z-score: 2088.2  bits: 393.8 E(85289): 1.4e-109
Smith-Waterman score: 1611; 100.0% identity (100.0% similar) in 240 aa overlap (1-240:1-240)

               10        20        30        40        50        60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
              190       200       210       220       230       240

>>NP_003798 (OMIM: 604520) tumor necrosis factor ligand   (240 aa)
 initn: 1611 init1: 1611 opt: 1611  Z-score: 2088.2  bits: 393.8 E(85289): 1.4e-109
Smith-Waterman score: 1611; 100.0% identity (100.0% similar) in 240 aa overlap (1-240:1-240)

               10        20        30        40        50        60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
              190       200       210       220       230       240

>>NP_742011 (OMIM: 604520) tumor necrosis factor ligand   (204 aa)
 initn: 1121 init1: 1121 opt: 1126  Z-score: 1461.3  bits: 277.6 E(85289): 1.2e-74
Smith-Waterman score: 1285; 85.0% identity (85.0% similar) in 240 aa overlap (1-240:1-204)

               10        20        30        40        50        60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
       :::::::::::::::::::::::::::::::::::::                       
NP_742 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVAR-----------------------
               10        20        30                              

               70        80        90       100       110       120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
                    :::::::::::::::::::::::::::::::::::::::::::::::
NP_742 -------------DGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
                     40        50        60        70        80    

              130       140       150       160       170       180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
           90       100       110       120       130       140    

              190       200       210       220       230       240
pF1KE0 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
          150       160       170       180       190       200    

>>XP_016882907 (OMIM: 604520) PREDICTED: tumor necrosis   (128 aa)
 initn: 672 init1: 672 opt: 672  Z-score: 876.3  bits: 168.6 E(85289): 4.5e-42
Smith-Waterman score: 672; 100.0% identity (100.0% similar) in 99 aa overlap (1-99:1-99)

               10        20        30        40        50        60
pF1KE0 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
       :::::::::::::::::::::::::::::::::::::::                     
XP_016 LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTVTTFGGHSEIRHRVKSGPVPG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
                                                                   
XP_016 SPGQTASL                                                    
                                                                   

>>NP_000630 (OMIM: 134638,211980,601859) tumor necrosis   (281 aa)
 initn: 196 init1: 146 opt: 295  Z-score: 383.8  bits: 78.6 E(85289): 1.2e-14
Smith-Waterman score: 295; 29.2% identity (62.8% similar) in 226 aa overlap (20-238:70-279)

                          10        20        30        40         
pF1KE0            MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGA
                                     :. . : .:    : ..   . .:. :.: 
NP_000 PGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRG-NHSTGLCLLVMFFM-VLVALVGL
      40        50        60        70         80         90       

      50         60        70         80            90       100   
pF1KE0 GLAVQGWF-LLQLHWRLGEMVTRLPD-GPAGSWEQLIQER----RSHEVNPAAHLTGANS
       ::   : : :..:. .:.:.     .   :.: :. : .     ...:.  .::::: ..
NP_000 GL---GMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSN
          100       110       120       130       140       150    

           110       120       130       140       150       160   
pF1KE0 SLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTIT
       : .    :: ::   :...: :..:. :.::....: :..:::: . : .:       ..
NP_000 SRSM---PLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCN---NLPLS
             160       170       180       190       200           

           170       180        190       200       210       220  
pF1KE0 HGLYKRTPRYPEELELLVSQQ-SPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDE
       : .: :. .::..: .. ... : :    .....:  ::.::.: .: ..... : : . 
NP_000 HKVYMRNSKYPQDLVMMEGKMMSYC----TTGQMWARSSYLGAVFNLTSADHLYVNVSEL
      210       220       230           240       250       260    

            230       240
pF1KE0 RLVRLRDGTRSYFGAFMV
        :: ... ....:: .  
NP_000 SLVNFEE-SQTFFGLYKL
          270        280 

>>NP_000585 (OMIM: 157300,191160,600807,611162) tumor ne  (233 aa)
 initn: 233 init1:  99 opt: 234  Z-score: 305.9  bits: 64.0 E(85289): 2.7e-10
Smith-Waterman score: 234; 30.7% identity (60.1% similar) in 153 aa overlap (88-236:82-229)

        60        70        80        90       100       110       
pF1KE0 LLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQ
                                     :.   .:.::.. :: .  :.   : : ..
NP_000 HFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVV-ANPQAEGQ---LQWLNR
              60        70        80        90        100          

       120        130       140       150       160       170      
pF1KE0 LGLAFL-RGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEE
        . :.:  :.  .:. ::: . : : :::.: . : ::: .    .:: . . .  :  .
NP_000 RANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCP-STHVLLTHTISRIAVSYQTK
       110       120       130       140        150       160      

        180       190          200       210       220       230   
pF1KE0 LELLVSQQSPCGRAT---SSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRS
       ..:: . .::: : :   . .. :..  .:::: .:: :... ...     . . .. . 
NP_000 VNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQV
        170       180       190       200       210       220      

           240
pF1KE0 YFGAFMV
       :::    
NP_000 YFGIIAL
        230   

>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga  (192 aa)
 initn: 192 init1:  88 opt: 222  Z-score: 291.5  bits: 61.0 E(85289): 1.7e-09
Smith-Waterman score: 229; 32.1% identity (58.6% similar) in 162 aa overlap (94-240:36-192)

            70        80        90       100          110          
pF1KE0 RLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTG---SGGPLL-WETQLG
                                     : :::: . .. :    .  : : :: .::
NP_001 GRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG
          10        20        30        40        50        60     

     120        130       140       150                 160        
pF1KE0 LAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV----------GCPLGLASTITHGLYK
       ::: .. ..: .  :.. ..: :.:::.: . :.          : : .  ..::  . :
NP_001 LAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRP-NKPDSITVVITK
          70        80        90       100       110        120    

      170       180       190       200       210       220        
pF1KE0 RTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLR
        :  :::  .::.. .: :  ...    :..  .::..  :. :.:..: : :  ::   
NP_001 VTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGAMFSLQEGDKLMVNVSDISLVDYT
          130       140           150       160       170       180

      230       240
pF1KE0 DGTRSYFGAFMV
          ...::::..
NP_001 KEDKTFFGAFLL
              190  

>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand   (251 aa)
 initn: 191 init1:  88 opt: 222  Z-score: 290.0  bits: 61.1 E(85289): 2.1e-09
Smith-Waterman score: 246; 28.2% identity (54.6% similar) in 238 aa overlap (20-240:26-251)

                     10        20        30        40          50  
pF1KE0       MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGL--GLLLLLMGAGLA
                                : .: . ..   .: .. . .  ::   :. . : 
NP_005 MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR
               10        20        30        40        50        60

             60        70        80        90       100            
pF1KE0 VQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTG---SG
       .::   .:..   :.         : : .:.    :.   .: :::: . .. :    . 
NP_005 AQGEACVQFQALKGQEF-------APSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQ
               70               80        90       100       110   

     110        120        130       140       150                 
pF1KE0 GPLL-WETQLGLAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV----------GCPLG
        : : :: .::::: .. ..: .  :.. ..: :.:::.: . :.          : : .
NP_005 FPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRP-N
           120       130       140       150       160       170   

       160       170       180       190       200       210       
pF1KE0 LASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVV
         ..::  . : :  :::  .::.. .: :  ...    :..  .::..  :. :.:..:
NP_005 KPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGAMFSLQEGDKLMV
            180       190       200           210       220        

       220       230       240
pF1KE0 RVLDERLVRLRDGTRSYFGAFMV
        : :  ::      ...::::..
NP_005 NVSDISLVDYTKEDKTFFGAFLL
      230       240       250 

>>NP_003801 (OMIM: 603598) tumor necrosis factor ligand   (281 aa)
 initn: 134 init1:  90 opt: 189  Z-score: 246.6  bits: 53.3 E(85289): 5.3e-07
Smith-Waterman score: 202; 26.2% identity (55.3% similar) in 206 aa overlap (60-240:79-280)

      30        40        50        60        70        80         
pF1KE0 RQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRS
                                     :..:.: ..: ..    .    . .::...
NP_003 YSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQ
       50        60        70        80        90       100        

      90                100                 110          120       
pF1KE0 H------EVNP---AAHLTGA----------NSSLTGSGGPLL--WET-QLGLAFLRGLS
       .      : .:   :::.::.          ::.   . :  .  ::. . : .:: .: 
NP_003 NISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLH
      110       120       130       140       150       160        

       130       140       150          160       170       180    
pF1KE0 YHDGALVVTKAGYYYIYSKVQLG---GVGCPLGLASTITHGLYKRTPRYPEELELLVSQQ
        ..: ::. . :.:::::.. .     .       . ... .:: :  ::. . :. : .
NP_003 LRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTS-YPDPILLMKSAR
      170       180       190       200       210        220       

          190       200       210       220       230       240 
pF1KE0 SPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV 
       . :    .   ..  : . ::. .:. .... : : .:.:. . :   :.::::.: 
NP_003 NSCWSKDAEYGLY--SIYQGGIFELKENDRIFVSVTNEHLIDM-DHEASFFGAFLVG
       230       240         250       260        270       280 

>>XP_016876292 (OMIM: 259710,602642) PREDICTED: tumor ne  (244 aa)
 initn: 104 init1:  49 opt: 179  Z-score: 234.5  bits: 50.8 E(85289): 2.5e-06
Smith-Waterman score: 179; 26.0% identity (54.6% similar) in 196 aa overlap (52-240:49-240)

              30        40        50        60        70         80
pF1KE0 TRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPA-GSW
                                     : ::    .:.  .: .  :   . . :::
XP_016 RLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSW
       20        30        40        50        60        70        

               90       100        110         120       130       
pF1KE0 EQLIQERRSHEVNPAAHLTGANSSL-TGSGGPLL--WETQLGLAFLRGLSYHDGALVVTK
        .: . : . :..: ::::   ... .::    :  :  . : : . .... .: :.:..
XP_016 LDLAK-RSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQ
       80         90       100       110       120       130       

       140       150       160          170       180       190    
pF1KE0 AGYYYIYSKVQLGGVGCPLGLASTITHGLY---KRTPRYPEELELLVSQQSPCGRATSSS
        :.::.:... .        ::.   . .    : . . :    :. . ..     ...:
XP_016 DGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTK--YWSGNS
       140       150       160       170       180         190     

          200       210       220       230       240    
pF1KE0 RVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV    
       .  . :  .::  .:..::.. ..: .  :.   :   .::::: :    
XP_016 EFHFYSINVGGFFKLRSGEEISIEVSNPSLLD-PDQDATYFGAFKVRDID
         200       210       220        230       240    




240 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 19:31:05 2016 done: Thu Nov  3 19:31:06 2016
 Total Scan time:  7.120 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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