Result of FASTA (omim) for pF1KE0095
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0095, 1261 aa
  1>>>pF1KE0095 1261 - 1261 aa - 1261 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.6271+/-0.000467; mu= 13.1201+/- 0.029
 mean_var=180.1553+/-37.632, 0's: 0 Z-trim(116.2): 131  B-trim: 2860 in 2/53
 Lambda= 0.095554
 statistics sampled from 27075 (27215) to 27075 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.319), width:  16
 Scan time: 15.980

The best scores are:                                      opt bits E(85289)
NP_899200 (OMIM: 600293,606703) adenylate cyclase  (1261) 8381 1169.1       0
XP_005247134 (OMIM: 600293,606703) PREDICTED: aden (1286) 6523 913.0       0
NP_001186571 (OMIM: 600293,606703) adenylate cycla ( 911) 5862 821.7       0
NP_056085 (OMIM: 600294,616287) adenylate cyclase  (1168) 5051 710.0 2.3e-203
XP_006719273 (OMIM: 600294,616287) PREDICTED: aden (1168) 5051 710.0 2.3e-203
XP_005247135 (OMIM: 600293,606703) PREDICTED: aden ( 936) 4004 565.6 5.4e-160
XP_016861127 (OMIM: 600293,606703) PREDICTED: aden ( 920) 4001 565.2 7.1e-160
XP_011510662 (OMIM: 600293,606703) PREDICTED: aden ( 923) 4000 565.1 7.8e-160
XP_006713546 (OMIM: 600293,606703) PREDICTED: aden ( 919) 3998 564.8 9.5e-160
XP_016861128 (OMIM: 600293,606703) PREDICTED: aden ( 920) 3998 564.8 9.5e-160
XP_011510661 (OMIM: 600293,606703) PREDICTED: aden ( 953) 3996 564.5 1.2e-159
XP_011510663 (OMIM: 600293,606703) PREDICTED: aden ( 845) 3581 507.3 1.8e-142
XP_016861129 (OMIM: 600293,606703) PREDICTED: aden ( 845) 3581 507.3 1.8e-142
XP_006713547 (OMIM: 600293,606703) PREDICTED: aden ( 845) 3581 507.3 1.8e-142
XP_016874232 (OMIM: 600294,616287) PREDICTED: aden (1067) 2669 381.6 1.5e-104
NP_001105 (OMIM: 600385) adenylate cyclase type 7  (1080) 1809 263.1 7.4e-69
XP_016878384 (OMIM: 600385) PREDICTED: adenylate c (1080) 1809 263.1 7.4e-69
NP_065433 (OMIM: 103071) adenylate cyclase type 2  (1091) 1767 257.3 4.1e-67
NP_001185497 (OMIM: 600292) adenylate cyclase type (1077) 1761 256.5 7.2e-67
NP_640340 (OMIM: 600292) adenylate cyclase type 4  (1077) 1761 256.5 7.2e-67
NP_001185521 (OMIM: 600292) adenylate cyclase type (1077) 1761 256.5 7.2e-67
XP_016878385 (OMIM: 600385) PREDICTED: adenylate c ( 886) 1703 248.4 1.6e-64
XP_016878386 (OMIM: 600385) PREDICTED: adenylate c ( 886) 1703 248.4 1.6e-64
XP_011521139 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
XP_011521141 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
XP_011521144 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
XP_011521138 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
XP_011521142 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
XP_011521137 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
XP_011521140 (OMIM: 600385) PREDICTED: adenylate c (1086) 1703 248.5 1.9e-64
NP_001106 (OMIM: 103070) adenylate cyclase type 8  (1251) 1601 234.5 3.5e-60
NP_004027 (OMIM: 600291) adenylate cyclase type 3  (1144) 1590 232.9 9.4e-60
NP_001307542 (OMIM: 600291) adenylate cyclase type (1145) 1589 232.8   1e-59
XP_005250826 (OMIM: 103070) PREDICTED: adenylate c (1221) 1586 232.4 1.4e-59
XP_016858682 (OMIM: 600291) PREDICTED: adenylate c ( 903) 1510 221.8 1.7e-56
XP_016858681 (OMIM: 600291) PREDICTED: adenylate c ( 904) 1509 221.7 1.8e-56
XP_016868496 (OMIM: 103070) PREDICTED: adenylate c ( 646) 1378 203.5 3.9e-51
XP_016868495 (OMIM: 103070) PREDICTED: adenylate c (1155) 1382 204.2 4.1e-51
XP_006716564 (OMIM: 103070) PREDICTED: adenylate c (1185) 1382 204.3 4.1e-51
XP_005249642 (OMIM: 103072,610154,610154) PREDICTE ( 563) 1325 196.1 5.6e-49
XP_005249641 (OMIM: 103072,610154,610154) PREDICTE ( 979) 1327 196.6 6.9e-49
NP_066939 (OMIM: 103072,610154,610154) adenylate c (1119) 1327 196.7 7.6e-49
XP_016858678 (OMIM: 600291) PREDICTED: adenylate c (1139) 1227 182.9 1.1e-44
XP_011530795 (OMIM: 600291) PREDICTED: adenylate c (1140) 1226 182.7 1.2e-44
NP_001268697 (OMIM: 103072,610154,610154) adenylat ( 338) 1179 175.8 4.4e-43
XP_016858679 (OMIM: 600291) PREDICTED: adenylate c (1098) 1074 161.8 2.4e-38
XP_016858676 (OMIM: 600291) PREDICTED: adenylate c (1163) 1062 160.1 7.8e-38
XP_011530793 (OMIM: 600291) PREDICTED: adenylate c (1164) 1062 160.1 7.8e-38
XP_011530796 (OMIM: 600291) PREDICTED: adenylate c (1120)  908 138.9 1.9e-31
XP_016858677 (OMIM: 600291) PREDICTED: adenylate c (1149)  908 138.9 1.9e-31


>>NP_899200 (OMIM: 600293,606703) adenylate cyclase type  (1261 aa)
 initn: 8381 init1: 8381 opt: 8381  Z-score: 6252.7  bits: 1169.1 E(85289):    0
Smith-Waterman score: 8381; 100.0% identity (100.0% similar) in 1261 aa overlap (1-1261:1-1261)

               10        20        30        40        50        60
pF1KE0 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE0 AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE0 RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE0 GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE0 TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE0 TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE0 WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE0 LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE0 QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE0 SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE0 DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE0 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
             1210      1220      1230      1240      1250      1260

        
pF1KE0 S
       :
NP_899 S
        

>>XP_005247134 (OMIM: 600293,606703) PREDICTED: adenylat  (1286 aa)
 initn: 6523 init1: 6523 opt: 6523  Z-score: 4868.3  bits: 913.0 E(85289):    0
Smith-Waterman score: 8311; 98.1% identity (98.1% similar) in 1286 aa overlap (1-1261:1-1286)

               10        20        30        40        50        60
pF1KE0 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE0 AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE0 RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE0 GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE0 TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE0 TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE0 WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
              910       920       930       940       950       960

              970                                980       990     
pF1KE0 LVTANAIDFFNNGTSQ---C----------------------PEHATKVALKVVTPIIIS
       ::::::::::::::::   :                      ::::::::::::::::::
XP_005 LVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIIS
              970       980       990      1000      1010      1020

        1000      1010      1020      1030      1040      1050     
pF1KE0 VFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLAR
             1030      1040      1050      1060      1070      1080

        1060      1070      1080      1090      1100      1110     
pF1KE0 ERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDR
             1090      1100      1110      1120      1130      1140

        1120      1130      1140      1150      1160      1170     
pF1KE0 FRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQM
             1150      1160      1170      1180      1190      1200

        1180      1190      1200      1210      1220      1230     
pF1KE0 KIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQL
             1210      1220      1230      1240      1250      1260

        1240      1250      1260 
pF1KE0 ECRGVVKVKGKGEMMTYFLNGGPPLS
       ::::::::::::::::::::::::::
XP_005 ECRGVVKVKGKGEMMTYFLNGGPPLS
             1270      1280      

>>NP_001186571 (OMIM: 600293,606703) adenylate cyclase t  (911 aa)
 initn: 5858 init1: 5858 opt: 5862  Z-score: 4377.8  bits: 821.7 E(85289):    0
Smith-Waterman score: 5862; 98.4% identity (99.4% similar) in 898 aa overlap (364-1261:14-911)

           340       350       360       370       380       390   
pF1KE0 FFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVG
                                     ....:.   ..  ..:::::::::::::::
NP_001                  MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
                                10        20        30        40   

           400       410       420       430       440       450   
pF1KE0 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
            50        60        70        80        90       100   

           460       470       480       490       500       510   
pF1KE0 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
           110       120       130       140       150       160   

           520       530       540       550       560       570   
pF1KE0 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
           170       180       190       200       210       220   

           580       590       600       610       620       630   
pF1KE0 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
           230       240       250       260       270       280   

           640       650       660       670       680       690   
pF1KE0 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
           290       300       310       320       330       340   

           700       710       720       730       740       750   
pF1KE0 KRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY
           350       360       370       380       390       400   

           760       770       780       790       800       810   
pF1KE0 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCV
           410       420       430       440       450       460   

           820       830       840       850       860       870   
pF1KE0 KLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISA
           470       480       490       500       510       520   

           880       890       900       910       920       930   
pF1KE0 SQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKL
           530       540       550       560       570       580   

           940       950       960       970       980       990   
pF1KE0 VLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPII
           590       600       610       620       630       640   

          1000      1010      1020      1030      1040      1050   
pF1KE0 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL
           650       660       670       680       690       700   

          1060      1070      1080      1090      1100      1110   
pF1KE0 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE
           710       720       730       740       750       760   

          1120      1130      1140      1150      1160      1170   
pF1KE0 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF
           770       780       790       800       810       820   

          1180      1190      1200      1210      1220      1230   
pF1KE0 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTY
           830       840       850       860       870       880   

          1240      1250      1260 
pF1KE0 QLECRGVVKVKGKGEMMTYFLNGGPPLS
       ::::::::::::::::::::::::::::
NP_001 QLECRGVVKVKGKGEMMTYFLNGGPPLS
           890       900       910 

>>NP_056085 (OMIM: 600294,616287) adenylate cyclase type  (1168 aa)
 initn: 4661 init1: 2353 opt: 5051  Z-score: 3772.2  bits: 710.0 E(85289): 2.3e-203
Smith-Waterman score: 5051; 68.0% identity (83.7% similar) in 1165 aa overlap (100-1258:16-1166)

      70        80        90       100       110       120         
pF1KE0 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
                                     :.:: ::.:.     .: .:::. .::   
NP_056                MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
                              10        20             30        40

     130       140       150       160       170       180         
pF1KE0 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
           .    .   . . .:    : . .. .  :::    . ::   ::  :  . .  .
NP_056 PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
               50        60        70          80        90        

     190       200       210        220       230       240        
pF1KE0 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
       .: . . ..: ::   :  :   :.:.:.::.: : :::::::::::..::::::.::::
NP_056 TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
      100       110       120       130       140       150        

      250       260       270       280       290       300        
pF1KE0 LVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAV
       :::.  :.::::::    :  :.:.:: :..... . :.::: .:.:: : .. :.....
NP_056 LVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGI
      160       170       180       190       200       210        

      310       320       330       340       350       360        
pF1KE0 VLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRT
       . :::: : :  .::: : :.:  :::.:  :::::.:::::::::. ::.::: .: . 
NP_056 LAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQL
      220       230       240       250       260       270        

      370       380       390       400       410       420        
pF1KE0 NAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQ
       :  : :: ::: .:::.: :::..:.::::::::::::::::::  :::::: :.::.::
NP_056 NRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQ
      280       290       300       310       320       330        

      430       440       450       460       470       480        
pF1KE0 ERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ
       :::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::::
NP_056 ERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ
      340       350       360       370       380       390        

      490       500       510       520       530       540        
pF1KE0 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_056 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAI
      400       410       420       430       440       450        

      550       560       570       580       590       600        
pF1KE0 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITK
       :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::.
NP_056 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITR
      460       470       480       490       500       510        

      610       620       630       640       650       660        
pF1KE0 ATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIG
       :::.::::::::::: ::::::::::. :::::::  .:::::::::.::..: :.::. 
NP_056 ATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSME
      520       530       540       550       560       570        

      670       680       690       700         710       720      
pF1KE0 HNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDA
          :.:  .: :      .. :: ...::..:  :: ...:.. ::::::::::.:::::
NP_056 GLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDA
      580       590           600       610       620       630    

        730       740       750       760       770       780      
pF1KE0 RSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHS
       ::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :::
NP_056 RSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHS
          640       650       660       670       680       690    

        790       800       810       820       830       840      
pF1KE0 IFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVF
        .::..: .  ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :::
NP_056 TLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVF
          700       710       720       730       740       750    

        850       860       870       880       890       900      
pF1KE0 LAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNF
        .:..::::::   . .: :.  :.. ....:::. .  .::::: .  .: .  :.:.:
NP_056 TSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ--LNYSLGLDAPLCEGTMPTCSF
          760       770       780       790         800       810  

        910       920       930       940        950       960     
pF1KE0 PEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTAN
       ::::  ..:::::: ::::.:: ::::...... ::: ::..  : .:.::: :::. ..
NP_056 PEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVH
            820       830       840       850       860       870  

         970         980       990      1000      1010      1020   
pF1KE0 AIDFFNNGTS--QCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQAT
       ..   :.  .  .::  : .:::: .::.:. ::.:::::::::::::::::::::::::
NP_056 GLASSNETFDGLDCPA-AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT
            880        890       900       910       920       930 

          1030      1040      1050      1060      1070      1080   
pF1KE0 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF
        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF
             940       950       960       970       980       990 

          1090      1100      1110      1120      1130      1140   
pF1KE0 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV
       ::::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::.:
NP_056 YVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQV
            1000      1010      1020      1030      1040      1050 

          1150      1160      1170      1180      1190      1200   
pF1KE0 GKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTV
       :..:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::::
NP_056 GRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTV
            1060      1070      1080      1090      1100      1110 

          1210      1220      1230      1240      1250      1260 
pF1KE0 NVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       ::.:::::::::::::::::.::::::. ::::::::::::::::: ::::::::   
NP_056 NVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
            1120      1130      1140      1150      1160         

>>XP_006719273 (OMIM: 600294,616287) PREDICTED: adenylat  (1168 aa)
 initn: 4661 init1: 2353 opt: 5051  Z-score: 3772.2  bits: 710.0 E(85289): 2.3e-203
Smith-Waterman score: 5051; 68.0% identity (83.7% similar) in 1165 aa overlap (100-1258:16-1166)

      70        80        90       100       110       120         
pF1KE0 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
                                     :.:: ::.:.     .: .:::. .::   
XP_006                MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
                              10        20             30        40

     130       140       150       160       170       180         
pF1KE0 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
           .    .   . . .:    : . .. .  :::    . ::   ::  :  . .  .
XP_006 PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
               50        60        70          80        90        

     190       200       210        220       230       240        
pF1KE0 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
       .: . . ..: ::   :  :   :.:.:.::.: : :::::::::::..::::::.::::
XP_006 TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
      100       110       120       130       140       150        

      250       260       270       280       290       300        
pF1KE0 LVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAV
       :::.  :.::::::    :  :.:.:: :..... . :.::: .:.:: : .. :.....
XP_006 LVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGI
      160       170       180       190       200       210        

      310       320       330       340       350       360        
pF1KE0 VLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRT
       . :::: : :  .::: : :.:  :::.:  :::::.:::::::::. ::.::: .: . 
XP_006 LAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQL
      220       230       240       250       260       270        

      370       380       390       400       410       420        
pF1KE0 NAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQ
       :  : :: ::: .:::.: :::..:.::::::::::::::::::  :::::: :.::.::
XP_006 NRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQ
      280       290       300       310       320       330        

      430       440       450       460       470       480        
pF1KE0 ERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ
       :::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::::
XP_006 ERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ
      340       350       360       370       380       390        

      490       500       510       520       530       540        
pF1KE0 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAI
       :::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_006 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAI
      400       410       420       430       440       450        

      550       560       570       580       590       600        
pF1KE0 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITK
       :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::.
XP_006 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITR
      460       470       480       490       500       510        

      610       620       630       640       650       660        
pF1KE0 ATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIG
       :::.::::::::::: ::::::::::. :::::::  .:::::::::.::..: :.::. 
XP_006 ATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSME
      520       530       540       550       560       570        

      670       680       690       700         710       720      
pF1KE0 HNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDA
          :.:  .: :      .. :: ...::..:  :: ...:.. ::::::::::.:::::
XP_006 GLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDA
      580       590           600       610       620       630    

        730       740       750       760       770       780      
pF1KE0 RSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHS
       ::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :::
XP_006 RSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHS
          640       650       660       670       680       690    

        790       800       810       820       830       840      
pF1KE0 IFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVF
        .::..: .  ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :::
XP_006 TLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVF
          700       710       720       730       740       750    

        850       860       870       880       890       900      
pF1KE0 LAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNF
        .:..::::::   . .: :.  :.. ....:::. .  .::::: .  .: .  :.:.:
XP_006 TSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ--LNYSLGLDAPLCEGTMPTCSF
          760       770       780       790         800       810  

        910       920       930       940        950       960     
pF1KE0 PEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTAN
       ::::  ..:::::: ::::.:: ::::...... ::: ::..  : .:.::: :::. ..
XP_006 PEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVH
            820       830       840       850       860       870  

         970         980       990      1000      1010      1020   
pF1KE0 AIDFFNNGTS--QCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQAT
       ..   :.  .  .::  : .:::: .::.:. ::.:::::::::::::::::::::::::
XP_006 GLASSNETFDGLDCPA-AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT
            880        890       900       910       920       930 

          1030      1040      1050      1060      1070      1080   
pF1KE0 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF
        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF
             940       950       960       970       980       990 

          1090      1100      1110      1120      1130      1140   
pF1KE0 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV
       ::::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::.:
XP_006 YVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQV
            1000      1010      1020      1030      1040      1050 

          1150      1160      1170      1180      1190      1200   
pF1KE0 GKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTV
       :..:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::::
XP_006 GRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTV
            1060      1070      1080      1090      1100      1110 

          1210      1220      1230      1240      1250      1260 
pF1KE0 NVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       ::.:::::::::::::::::.::::::. ::::::::::::::::: ::::::::   
XP_006 NVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 
            1120      1130      1140      1150      1160         

>>XP_005247135 (OMIM: 600293,606703) PREDICTED: adenylat  (936 aa)
 initn: 4000 init1: 4000 opt: 4004  Z-score: 2993.4  bits: 565.6 E(85289): 5.4e-160
Smith-Waterman score: 5792; 95.8% identity (96.7% similar) in 923 aa overlap (364-1261:14-936)

           340       350       360       370       380       390   
pF1KE0 FFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVG
                                     ....:.   ..  ..:::::::::::::::
XP_005                  MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
                                10        20        30        40   

           400       410       420       430       440       450   
pF1KE0 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
            50        60        70        80        90       100   

           460       470       480       490       500       510   
pF1KE0 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
           110       120       130       140       150       160   

           520       530       540       550       560       570   
pF1KE0 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
           170       180       190       200       210       220   

           580       590       600       610       620       630   
pF1KE0 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
           230       240       250       260       270       280   

           640       650       660       670       680       690   
pF1KE0 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
           290       300       310       320       330       340   

           700       710       720       730       740       750   
pF1KE0 KRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY
           350       360       370       380       390       400   

           760       770       780       790       800       810   
pF1KE0 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCV
           410       420       430       440       450       460   

           820       830       840       850       860       870   
pF1KE0 KLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISA
           470       480       490       500       510       520   

           880       890       900       910       920       930   
pF1KE0 SQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKL
           530       540       550       560       570       580   

           940       950       960       970                       
pF1KE0 VLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQ---C-------------
       :::::::::::::::::::::::::::::::::::::::::::   :             
XP_005 VLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTY
           590       600       610       620       630       640   

                980       990      1000      1010      1020        
pF1KE0 ---------PEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEE
                :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEE
           650       660       670       680       690       700   

     1030      1040      1050      1060      1070      1080        
pF1KE0 MEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE
           710       720       730       740       750       760   

     1090      1100      1110      1120      1130      1140        
pF1KE0 ANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHI
           770       780       790       800       810       820   

     1150      1160      1170      1180      1190      1200        
pF1KE0 KALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASR
           830       840       850       860       870       880   

     1210      1220      1230      1240      1250      1260 
pF1KE0 MDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
           890       900       910       920       930      

>>XP_016861127 (OMIM: 600293,606703) PREDICTED: adenylat  (920 aa)
 initn: 3997 init1: 3997 opt: 4001  Z-score: 2991.2  bits: 565.2 E(85289): 7.1e-160
Smith-Waterman score: 5789; 96.0% identity (96.7% similar) in 923 aa overlap (364-1261:1-920)

           340       350       360       370       380       390   
pF1KE0 FFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVG
                                     ..:.:. . .:   .:::::::::::::::
XP_016                               MGLKTQWRHSF---RLVSNVLIFSCTNIVG
                                             10           20       

           400       410       420       430       440       450   
pF1KE0 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
        30        40        50        60        70        80       

           460       470       480       490       500       510   
pF1KE0 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
        90       100       110       120       130       140       

           520       530       540       550       560       570   
pF1KE0 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
       150       160       170       180       190       200       

           580       590       600       610       620       630   
pF1KE0 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
       210       220       230       240       250       260       

           640       650       660       670       680       690   
pF1KE0 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
       270       280       290       300       310       320       

           700       710       720       730       740       750   
pF1KE0 KRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY
       330       340       350       360       370       380       

           760       770       780       790       800       810   
pF1KE0 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCV
       390       400       410       420       430       440       

           820       830       840       850       860       870   
pF1KE0 KLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISA
       450       460       470       480       490       500       

           880       890       900       910       920       930   
pF1KE0 SQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKL
       510       520       530       540       550       560       

           940       950       960       970                       
pF1KE0 VLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQ---C-------------
       :::::::::::::::::::::::::::::::::::::::::::   :             
XP_016 VLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTY
       570       580       590       600       610       620       

                980       990      1000      1010      1020        
pF1KE0 ---------PEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEE
                :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEE
       630       640       650       660       670       680       

     1030      1040      1050      1060      1070      1080        
pF1KE0 MEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE
       690       700       710       720       730       740       

     1090      1100      1110      1120      1130      1140        
pF1KE0 ANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHI
       750       760       770       780       790       800       

     1150      1160      1170      1180      1190      1200        
pF1KE0 KALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASR
       810       820       830       840       850       860       

     1210      1220      1230      1240      1250      1260 
pF1KE0 MDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       870       880       890       900       910       920

>>XP_011510662 (OMIM: 600293,606703) PREDICTED: adenylat  (923 aa)
 initn: 4000 init1: 4000 opt: 4000  Z-score: 2990.5  bits: 565.1 E(85289): 7.8e-160
Smith-Waterman score: 5788; 97.1% identity (97.1% similar) in 910 aa overlap (377-1261:14-923)

        350       360       370       380       390       400      
pF1KE0 MRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQ
                                     : ::::::::::::::::::::::::::::
XP_011                  MLLIRLRDFPSIPKLLVSNVLIFSCTNIVGVCTHYPAEVSQRQ
                                10        20        30        40   

        410       420       430       440       450       460      
pF1KE0 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHD
            50        60        70        80        90       100   

        470       480       490       500       510       520      
pF1KE0 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
           110       120       130       140       150       160   

        530       540       550       560       570       580      
pF1KE0 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
           170       180       190       200       210       220   

        590       600       610       620       630       640      
pF1KE0 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCT
           230       240       250       260       270       280   

        650       660       670       680       690       700      
pF1KE0 QKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNA
           290       300       310       320       330       340   

        710       720       730       740       750       760      
pF1KE0 QESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVA
           350       360       370       380       390       400   

        770       780       790       800       810       820      
pF1KE0 CASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRK
           410       420       430       440       450       460   

        830       840       850       860       870       880      
pF1KE0 IVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAV
           470       480       490       500       510       520   

        890       900       910       920       930       940      
pF1KE0 NYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLI
           530       540       550       560       570       580   

        950       960       970                                980 
pF1KE0 VEVPGVTLFDNADLLVTANAIDFFNNGTSQ---C----------------------PEHA
       ::::::::::::::::::::::::::::::   :                      ::::
XP_011 VEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHA
           590       600       610       620       630       640   

             990      1000      1010      1020      1030      1040 
pF1KE0 TKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLH
           650       660       670       680       690       700   

            1050      1060      1070      1080      1090      1100 
pF1KE0 NILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLN
           710       720       730       740       750       760   

            1110      1120      1130      1140      1150      1160 
pF1KE0 EIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQ
           770       780       790       800       810       820   

            1170      1180      1190      1200      1210      1220 
pF1KE0 MKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT
           830       840       850       860       870       880   

            1230      1240      1250      1260 
pF1KE0 TDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       ::::::::::::::::::::::::::::::::::::::::
XP_011 TDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
           890       900       910       920   

>>XP_006713546 (OMIM: 600293,606703) PREDICTED: adenylat  (919 aa)
 initn: 3998 init1: 3998 opt: 3998  Z-score: 2989.0  bits: 564.8 E(85289): 9.5e-160
Smith-Waterman score: 5786; 97.1% identity (97.2% similar) in 909 aa overlap (378-1261:11-919)

       350       360       370       380       390       400       
pF1KE0 RAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQA
                                     .:::::::::::::::::::::::::::::
XP_006                     MAPSRFRTQLELVSNVLIFSCTNIVGVCTHYPAEVSQRQA
                                   10        20        30        40

       410       420       430       440       450       460       
pF1KE0 FQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDN
               50        60        70        80        90       100

       470       480       490       500       510       520       
pF1KE0 VSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP
              110       120       130       140       150       160

       530       540       550       560       570       580       
pF1KE0 EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSN
              170       180       190       200       210       220

       590       600       610       620       630       640       
pF1KE0 DVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQ
              230       240       250       260       270       280

       650       660       670       680       690       700       
pF1KE0 KRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQ
              290       300       310       320       330       340

       710       720       730       740       750       760       
pF1KE0 ESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVAC
              350       360       370       380       390       400

       770       780       790       800       810       820       
pF1KE0 ASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKI
              410       420       430       440       450       460

       830       840       850       860       870       880       
pF1KE0 VRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVN
              470       480       490       500       510       520

       890       900       910       920       930       940       
pF1KE0 YSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIV
              530       540       550       560       570       580

       950       960       970                                980  
pF1KE0 EVPGVTLFDNADLLVTANAIDFFNNGTSQ---C----------------------PEHAT
       :::::::::::::::::::::::::::::   :                      :::::
XP_006 EVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHAT
              590       600       610       620       630       640

            990      1000      1010      1020      1030      1040  
pF1KE0 KVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHN
              650       660       670       680       690       700

           1050      1060      1070      1080      1090      1100  
pF1KE0 ILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNE
              710       720       730       740       750       760

           1110      1120      1130      1140      1150      1160  
pF1KE0 IIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQM
              770       780       790       800       810       820

           1170      1180      1190      1200      1210      1220  
pF1KE0 KYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT
              830       840       850       860       870       880

           1230      1240      1250      1260 
pF1KE0 DMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       :::::::::::::::::::::::::::::::::::::::
XP_006 DMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
              890       900       910         

>>XP_016861128 (OMIM: 600293,606703) PREDICTED: adenylat  (920 aa)
 initn: 3998 init1: 3998 opt: 3998  Z-score: 2989.0  bits: 564.8 E(85289): 9.5e-160
Smith-Waterman score: 5786; 97.1% identity (97.2% similar) in 909 aa overlap (378-1261:12-920)

       350       360       370       380       390       400       
pF1KE0 RAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQA
                                     .:::::::::::::::::::::::::::::
XP_016                    MQTSACCPEWAKLVSNVLIFSCTNIVGVCTHYPAEVSQRQA
                                  10        20        30        40 

       410       420       430       440       450       460       
pF1KE0 FQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDN
              50        60        70        80        90       100 

       470       480       490       500       510       520       
pF1KE0 VSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP
             110       120       130       140       150       160 

       530       540       550       560       570       580       
pF1KE0 EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSN
             170       180       190       200       210       220 

       590       600       610       620       630       640       
pF1KE0 DVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQ
             230       240       250       260       270       280 

       650       660       670       680       690       700       
pF1KE0 KRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQ
             290       300       310       320       330       340 

       710       720       730       740       750       760       
pF1KE0 ESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVAC
             350       360       370       380       390       400 

       770       780       790       800       810       820       
pF1KE0 ASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKI
             410       420       430       440       450       460 

       830       840       850       860       870       880       
pF1KE0 VRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVN
             470       480       490       500       510       520 

       890       900       910       920       930       940       
pF1KE0 YSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIV
             530       540       550       560       570       580 

       950       960       970                                980  
pF1KE0 EVPGVTLFDNADLLVTANAIDFFNNGTSQ---C----------------------PEHAT
       :::::::::::::::::::::::::::::   :                      :::::
XP_016 EVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHAT
             590       600       610       620       630       640 

            990      1000      1010      1020      1030      1040  
pF1KE0 KVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHN
             650       660       670       680       690       700 

           1050      1060      1070      1080      1090      1100  
pF1KE0 ILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNE
             710       720       730       740       750       760 

           1110      1120      1130      1140      1150      1160  
pF1KE0 IIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQM
             770       780       790       800       810       820 

           1170      1180      1190      1200      1210      1220  
pF1KE0 KYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT
             830       840       850       860       870       880 

           1230      1240      1250      1260 
pF1KE0 DMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
       :::::::::::::::::::::::::::::::::::::::
XP_016 DMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
             890       900       910       920




1261 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 03:27:41 2016 done: Fri Nov  4 03:27:43 2016
 Total Scan time: 15.980 Total Display time:  0.440

Function used was FASTA [36.3.4 Apr, 2011]
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