Result of FASTA (omim) for pF1KE0094
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0094, 535 aa
  1>>>pF1KE0094 535 - 535 aa - 535 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2175+/-0.000458; mu= 20.2449+/- 0.028
 mean_var=85.9934+/-17.267, 0's: 0 Z-trim(111.6): 90  B-trim: 0 in 0/49
 Lambda= 0.138306
 statistics sampled from 20130 (20221) to 20130 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.599), E-opt: 0.2 (0.237), width:  16
 Scan time:  8.830

The best scores are:                                      opt bits E(85289)
NP_055415 (OMIM: 605891) EH domain-containing prot ( 535) 3558 720.4 3.4e-207
XP_011543041 (OMIM: 605888) PREDICTED: EH domain-c ( 534) 3188 646.6 5.6e-185
NP_006786 (OMIM: 605888) EH domain-containing prot ( 534) 3188 646.6 5.6e-185
NP_001269373 (OMIM: 605888) EH domain-containing p ( 534) 3188 646.6 5.6e-185
NP_001269374 (OMIM: 605888) EH domain-containing p ( 548) 3188 646.6 5.7e-185
NP_644670 (OMIM: 605892) EH domain-containing prot ( 541) 2748 558.8 1.5e-158
NP_055416 (OMIM: 605890) EH domain-containing prot ( 543) 2608 530.8 3.9e-150
XP_016877589 (OMIM: 605892) PREDICTED: EH domain-c ( 453) 2330 475.3 1.7e-133
XP_011531108 (OMIM: 605891) PREDICTED: EH domain-c ( 322) 2131 435.5 1.2e-121
NP_001310597 (OMIM: 604992) sarcalumenin isoform 2 ( 431)  755 161.0 6.6e-39
XP_016879017 (OMIM: 604992) PREDICTED: sarcalumeni ( 431)  755 161.0 6.6e-39
NP_001310596 (OMIM: 604992) sarcalumenin isoform 2 ( 431)  755 161.0 6.6e-39
XP_016879018 (OMIM: 604992) PREDICTED: sarcalumeni ( 431)  755 161.0 6.6e-39
NP_001092284 (OMIM: 604992) sarcalumenin isoform 1 ( 473)  755 161.1 7.1e-39
XP_016879016 (OMIM: 604992) PREDICTED: sarcalumeni ( 857)  755 161.3 1.1e-38
XP_016856106 (OMIM: 600051) PREDICTED: epidermal g ( 828)  332 76.9 2.7e-13
XP_016856105 (OMIM: 600051) PREDICTED: epidermal g ( 865)  332 76.9 2.8e-13
NP_001972 (OMIM: 600051) epidermal growth factor r ( 896)  332 76.9 2.9e-13
XP_016856104 (OMIM: 600051) PREDICTED: epidermal g ( 933)  332 76.9   3e-13
NP_001245305 (OMIM: 616826) epidermal growth facto ( 601)  327 75.8 4.3e-13
XP_016882581 (OMIM: 616826) PREDICTED: epidermal g ( 750)  327 75.8 5.1e-13
NP_001245304 (OMIM: 616826) epidermal growth facto ( 754)  327 75.8 5.1e-13
XP_016882580 (OMIM: 616826) PREDICTED: epidermal g ( 796)  327 75.9 5.3e-13
XP_016882579 (OMIM: 616826) PREDICTED: epidermal g ( 797)  327 75.9 5.3e-13
XP_016882578 (OMIM: 616826) PREDICTED: epidermal g ( 845)  327 75.9 5.5e-13
NP_067058 (OMIM: 616826) epidermal growth factor r ( 864)  327 75.9 5.6e-13
XP_016882577 (OMIM: 616826) PREDICTED: epidermal g ( 874)  327 75.9 5.7e-13
NP_001245303 (OMIM: 616826) epidermal growth facto ( 910)  327 75.9 5.8e-13
XP_016882576 (OMIM: 616826) PREDICTED: epidermal g ( 915)  327 75.9 5.8e-13
XP_016882575 (OMIM: 616826) PREDICTED: epidermal g ( 926)  327 75.9 5.9e-13
XP_011527995 (OMIM: 602442) PREDICTED: intersectin (1020)  257 62.0   1e-08
XP_016883930 (OMIM: 602442) PREDICTED: intersectin (1025)  257 62.0   1e-08
XP_011527994 (OMIM: 602442) PREDICTED: intersectin (1107)  257 62.0 1.1e-08
XP_016883929 (OMIM: 602442) PREDICTED: intersectin (1112)  257 62.0 1.1e-08
NP_001317940 (OMIM: 602442) intersectin-1 isoform  (1144)  257 62.0 1.1e-08
NP_001317937 (OMIM: 602442) intersectin-1 isoform  (1149)  257 62.0 1.1e-08
NP_001317941 (OMIM: 602442) intersectin-1 isoform  (1178)  257 62.1 1.1e-08
XP_016883927 (OMIM: 602442) PREDICTED: intersectin (1183)  257 62.1 1.1e-08
NP_001317938 (OMIM: 602442) intersectin-1 isoform  (1215)  257 62.1 1.1e-08
NP_001001132 (OMIM: 602442) intersectin-1 isoform  (1220)  257 62.1 1.2e-08
XP_016883925 (OMIM: 602442) PREDICTED: intersectin (1608)  257 62.2 1.4e-08
XP_016883924 (OMIM: 602442) PREDICTED: intersectin (1613)  257 62.2 1.4e-08
XP_016883923 (OMIM: 602442) PREDICTED: intersectin (1645)  257 62.2 1.4e-08
XP_016883922 (OMIM: 602442) PREDICTED: intersectin (1650)  257 62.2 1.4e-08
XP_016883921 (OMIM: 602442) PREDICTED: intersectin (1660)  257 62.2 1.4e-08
XP_016883920 (OMIM: 602442) PREDICTED: intersectin (1665)  257 62.2 1.4e-08
XP_016883919 (OMIM: 602442) PREDICTED: intersectin (1679)  257 62.2 1.5e-08
XP_016883918 (OMIM: 602442) PREDICTED: intersectin (1684)  257 62.2 1.5e-08
NP_001317939 (OMIM: 602442) intersectin-1 isoform  (1716)  257 62.2 1.5e-08
XP_016883917 (OMIM: 602442) PREDICTED: intersectin (1721)  257 62.2 1.5e-08


>>NP_055415 (OMIM: 605891) EH domain-containing protein   (535 aa)
 initn: 3558 init1: 3558 opt: 3558  Z-score: 3840.9  bits: 720.4 E(85289): 3.4e-207
Smith-Waterman score: 3558; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)

               10        20        30        40        50        60
pF1KE0 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 DQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 PFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSV
              430       440       450       460       470       480

              490       500       510       520       530     
pF1KE0 LGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
              490       500       510       520       530     

>>XP_011543041 (OMIM: 605888) PREDICTED: EH domain-conta  (534 aa)
 initn: 3220 init1: 3188 opt: 3188  Z-score: 3441.9  bits: 646.6 E(85289): 5.6e-185
Smith-Waterman score: 3188; 87.0% identity (97.2% similar) in 532 aa overlap (1-532:1-532)

               10        20        30        40        50        60
pF1KE0 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
       ::::.. : ::.:.::.::::.:::..:: .:::::::::::::::::::::::::::::
XP_011 MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKK
       ::::::::::::::::.:.::::::::::::::::::::::.:  ::..:::::::::..
XP_011 VLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAE
       ::::::::::::::::.:::::::::.:::.:::::::::::::::::::::::::::::
XP_011 PFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSL
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKR
       :::.:::::.:::::::::::::::::::::::::::::.::::::::::::::::::::
XP_011 GKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQ
       :::::::::::::::::::.::::..:::::::::.::: .:::::::::::::.:..::
XP_011 ARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 DQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHG
       . ::.::::::: :: :::..::::::.:::.:::.::::::  : :.::::::.::..:
XP_011 ELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 PFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSV
       ::::::::::::::::.::::..::: :::::::::::.:::::::::::::.:::::.:
XP_011 PFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTV
              430       440       450       460       470       480

              490       500       510       520       530     
pF1KE0 LGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       :::::::::.::::.:::.::::::::::::::::::: .:: ::.:::::.   
XP_011 LGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE 
              490       500       510       520       530     

>>NP_006786 (OMIM: 605888) EH domain-containing protein   (534 aa)
 initn: 3220 init1: 3188 opt: 3188  Z-score: 3441.9  bits: 646.6 E(85289): 5.6e-185
Smith-Waterman score: 3188; 87.0% identity (97.2% similar) in 532 aa overlap (1-532:1-532)

               10        20        30        40        50        60
pF1KE0 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
       ::::.. : ::.:.::.::::.:::..:: .:::::::::::::::::::::::::::::
NP_006 MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKK
       ::::::::::::::::.:.::::::::::::::::::::::.:  ::..:::::::::..
NP_006 VLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAE
       ::::::::::::::::.:::::::::.:::.:::::::::::::::::::::::::::::
NP_006 PFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSL
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_006 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKR
       :::.:::::.:::::::::::::::::::::::::::::.::::::::::::::::::::
NP_006 GKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQ
       :::::::::::::::::::.::::..:::::::::.::: .:::::::::::::.:..::
NP_006 ARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 DQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHG
       . ::.::::::: :: :::..::::::.:::.:::.::::::  : :.::::::.::..:
NP_006 ELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 PFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSV
       ::::::::::::::::.::::..::: :::::::::::.:::::::::::::.:::::.:
NP_006 PFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTV
              430       440       450       460       470       480

              490       500       510       520       530     
pF1KE0 LGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       :::::::::.::::.:::.::::::::::::::::::: .:: ::.:::::.   
NP_006 LGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE 
              490       500       510       520       530     

>>NP_001269373 (OMIM: 605888) EH domain-containing prote  (534 aa)
 initn: 3220 init1: 3188 opt: 3188  Z-score: 3441.9  bits: 646.6 E(85289): 5.6e-185
Smith-Waterman score: 3188; 87.0% identity (97.2% similar) in 532 aa overlap (1-532:1-532)

               10        20        30        40        50        60
pF1KE0 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
       ::::.. : ::.:.::.::::.:::..:: .:::::::::::::::::::::::::::::
NP_001 MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKK
       ::::::::::::::::.:.::::::::::::::::::::::.:  ::..:::::::::..
NP_001 VLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAE
       ::::::::::::::::.:::::::::.:::.:::::::::::::::::::::::::::::
NP_001 PFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSL
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKR
       :::.:::::.:::::::::::::::::::::::::::::.::::::::::::::::::::
NP_001 GKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQ
       :::::::::::::::::::.::::..:::::::::.::: .:::::::::::::.:..::
NP_001 ARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 DQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHG
       . ::.::::::: :: :::..::::::.:::.:::.::::::  : :.::::::.::..:
NP_001 ELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 PFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSV
       ::::::::::::::::.::::..::: :::::::::::.:::::::::::::.:::::.:
NP_001 PFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTV
              430       440       450       460       470       480

              490       500       510       520       530     
pF1KE0 LGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       :::::::::.::::.:::.::::::::::::::::::: .:: ::.:::::.   
NP_001 LGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE 
              490       500       510       520       530     

>>NP_001269374 (OMIM: 605888) EH domain-containing prote  (548 aa)
 initn: 3220 init1: 3188 opt: 3188  Z-score: 3441.8  bits: 646.6 E(85289): 5.7e-185
Smith-Waterman score: 3188; 87.0% identity (97.2% similar) in 532 aa overlap (1-532:15-546)

                             10        20        30        40      
pF1KE0               MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFH
                     ::::.. : ::.:.::.::::.:::..:: .:::::::::::::::
NP_001 MEQPGTAASPVSGSMFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFH
               10        20        30        40        50        60

         50        60        70        80        90       100      
pF1KE0 SPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDME
       ::::::::::::::::::::::::::::::.:.::::::::::::::::::::::.:  :
NP_001 SPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTE
               70        80        90       100       110       120

        110       120       130       140       150       160      
pF1KE0 GIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRIS
       :..:::::::::..::::::::::::::::.:::::::::.:::.:::::::::::::::
NP_001 GVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRIS
              130       140       150       160       170       180

        170       180       190       200       210       220      
pF1KE0 RGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIET
       :::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_001 RGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIET
              190       200       210       220       230       240

        230       240       250       260       270       280      
pF1KE0 QQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLP
       :::::::::::::::::.:::::.:::::::::::::::::::::::::::::.::::::
NP_001 QQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLP
              250       260       270       280       290       300

        290       300       310       320       330       340      
pF1KE0 RNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREH
       :::::::::::::::::::::::::::::::::.::::..:::::::::.::: .:::::
NP_001 RNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREH
              310       320       330       340       350       360

        350       360       370       380       390       400      
pF1KE0 QISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPI
       ::::::::.:..::. ::.::::::: :: :::..::::::.:::.:::.::::::  : 
NP_001 QISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPS
              370       380       390       400       410       420

        410       420       430       440       450       460      
pF1KE0 QMVKGGAFEGTLHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGAN
       :.::::::.::..:::::::::::::::::.::::..::: :::::::::::.:::::::
NP_001 QVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGAN
              430       440       450       460       470       480

        470       480       490       500       510       520      
pF1KE0 AKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLL
       ::::::.:::::.::::::::::.::::.:::.::::::::::::::::::: .:: ::.
NP_001 AKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLV
              490       500       510       520       530       540

        530     
pF1KE0 PPSKRKVAE
       :::::.   
NP_001 PPSKRRHE 
                

>>NP_644670 (OMIM: 605892) EH domain-containing protein   (541 aa)
 initn: 2751 init1: 2719 opt: 2748  Z-score: 2967.3  bits: 558.8 E(85289): 1.5e-158
Smith-Waterman score: 2748; 75.3% identity (90.7% similar) in 535 aa overlap (1-532:1-535)

                 10         20        30        40        50       
pF1KE0 MFSWLGTD--DRRRKD-PEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDN
       ::::.: .   :.:    .. :::. ::..::  :.::::: ::::::::::::::::.:
NP_644 MFSWMGRQAGGRERAGGADAVQTVTGGLRSLYLRKVLPLEEAYRFHEFHSPALEDADFEN
               10        20        30        40        50        60

        60        70        80        90       100       110       
pF1KE0 KPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVD
       :::.:::::::::::::::::::::::::::::::::::::::: :. ::  ::::::::
NP_644 KPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVD
               70        80        90       100       110       120

       120       130       140       150       160       170       
pF1KE0 PKKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEW
       ::::::::. :::::::::.:.:::: ::.::::::.:::::::::::::::::  ::.:
NP_644 PKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQW
              130       140       150       160       170       180

       180       190       200       210       220       230       
pF1KE0 FAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALM
       :::::::::::::::::::::::::.:::.....::.:::::::::..::::::::::::
NP_644 FAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALM
              190       200       210       220       230       240

       240       250       260       270       280       290       
pF1KE0 WSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDL
       :::::..:::::.::::::::..::   :::.::::: :::::::::::..::.::::::
NP_644 WSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDL
              250       260       270       280       290       300

       300       310       320       330       340       350       
pF1KE0 IKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLK
       ::::::::::::::: :::::::::::.:::.::.. : ::: ...::.::: ::::..:
NP_644 IKRARLAKVHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPEVK
              310       320       330       340       350       360

       360       370       380       390       400       410       
pF1KE0 RMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGT
        ::.::.  ::.::. :: ::.:.::.::.. :. :: :. :::.. : :.:.::::.::
NP_644 AMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEETSTPTQLVQGGAFDGT
              370       380       390       400       410       420

       420       430       440       450       460       470       
pF1KE0 LHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLP
        .:::..:::::: :: :. :::::.:::.:::.::::::..:::.:.::::::: ::::
NP_644 TEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLP
              430       440       450       460       470       480

       480       490       500       510       520       530       
pF1KE0 NSVLGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE  
       :::::::::::: : :::::..:::::.::::.::.:.:::. :: ::.:::.::     
NP_644 NSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRKSLPKA
              490       500       510       520       530       540

NP_644 D
        

>>NP_055416 (OMIM: 605890) EH domain-containing protein   (543 aa)
 initn: 2602 init1: 2142 opt: 2608  Z-score: 2816.3  bits: 530.8 E(85289): 3.9e-150
Smith-Waterman score: 2608; 71.7% identity (89.0% similar) in 537 aa overlap (1-532:1-537)

               10        20        30        40        50        60
pF1KE0 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
       :::::     : ..::...::. .::.::..:::::::::::  ::::::::::::.:::
NP_055 MFSWLKRGGARGQQPEAIRTVTSALKELYRTKLLPLEEHYRFGAFHSPALEDADFDGKPM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 VLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKK
       ::..::::::::.::.:::::. :: :.::::::: :.:::.:: :: .::::::::: :
NP_055 VLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGDTEGTVPGNALVVDPDK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAE
       :::::: :::.:::::.:::::: ::::::.::::::::: :::.:::::: :::.::::
NP_055 PFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSL
       ::: ::::::::::.:::::::.: ::..::::.::::::::..::::::::::::::.:
NP_055 RVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 GKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKR
       ::.:.::::.:::::::::.:::.::::.::: ::::::::::.:::.:::::::::.::
NP_055 GKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 ARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQ
       :::..::::::: :::::::::::.::::.:. .:  :...:. ::.:::::::. ..::
NP_055 ARLVRVHAYIISYLKKEMPSVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 DQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHG
       . :.:.::.::. :: ::::..:.::.::::.:: :.:::: .     :.:::::::  :
NP_055 ELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTEVGVQGGAFEGTHMG
              370       380       390       400       410       420

                  430        440       450       460       470     
pF1KE0 PF---GHGYG-EGAGEGIDD-AEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSK
       ::   :   . : . :: :: :::::..::  ::::::.:.:.:::..:..::  :: .:
NP_055 PFVERGPDEAMEDGEEGSDDEAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTK
              430       440       450       460       470       480

         480       490       500       510       520       530     
pF1KE0 LPNSVLGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       :::::::.::::.:.:.::::::.:::::.:::..::::: :: .:: .:.:::::.   
NP_055 LPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPANLPRRLVPPSKRRHKG
              490       500       510       520       530       540

NP_055 SAE
          

>>XP_016877589 (OMIM: 605892) PREDICTED: EH domain-conta  (453 aa)
 initn: 2330 init1: 2330 opt: 2330  Z-score: 2517.6  bits: 475.3 E(85289): 1.7e-133
Smith-Waterman score: 2330; 75.8% identity (91.7% similar) in 447 aa overlap (86-532:1-447)

          60        70        80        90       100       110     
pF1KE0 DNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALV
                                     :::::::::::::::: :. ::  ::::::
XP_016                               MRIGPEPTTDSFIAVMYGETEGSTPGNALV
                                             10        20        30

         120       130       140       150       160       170     
pF1KE0 VDPKKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVL
       ::::::::::. :::::::::.:.:::: ::.::::::.:::::::::::::::::  ::
XP_016 VDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVL
               40        50        60        70        80        90

         180       190       200       210       220       230     
pF1KE0 EWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGA
       .::::::::::::::::::::::::::.:::.....::.:::::::::..::::::::::
XP_016 QWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGA
              100       110       120       130       140       150

         240       250       260       270       280       290     
pF1KE0 LMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLN
       :::::::..:::::.::::::::..::   :::.::::: :::::::::::..::.::::
XP_016 LMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLN
              160       170       180       190       200       210

         300       310       320       330       340       350     
pF1KE0 DLIKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPN
       ::::::::::::::::: :::::::::::.:::.::.. : ::: ...::.::: ::::.
XP_016 DLIKRARLAKVHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPE
              220       230       240       250       260       270

         360       370       380       390       400       410     
pF1KE0 LKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFE
       .: ::.::.  ::.::. :: ::.:.::.::.. :. :: :. :::.. : :.:.::::.
XP_016 VKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEETSTPTQLVQGGAFD
              280       290       300       310       320       330

         420       430       440       450       460       470     
pF1KE0 GTLHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSK
       :: .:::..:::::: :: :. :::::.:::.:::.::::::..:::.:.::::::: ::
XP_016 GTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSK
              340       350       360       370       380       390

         480       490       500       510       520       530     
pF1KE0 LPNSVLGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       :::::::::::::: : :::::..:::::.::::.::.:.:::. :: ::.:::.::   
XP_016 LPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRKSLP
              400       410       420       430       440       450

XP_016 KAD
          

>>XP_011531108 (OMIM: 605891) PREDICTED: EH domain-conta  (322 aa)
 initn: 2131 init1: 2131 opt: 2131  Z-score: 2304.9  bits: 435.5 E(85289): 1.2e-121
Smith-Waterman score: 2131; 100.0% identity (100.0% similar) in 322 aa overlap (214-535:1-322)

           190       200       210       220       230       240   
pF1KE0 RIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSLGKI
                                     ::::::::::::::::::::::::::::::
XP_011                               MRVVLNKADQIETQQLMRVYGALMWSLGKI
                                             10        20        30

           250       260       270       280       290       300   
pF1KE0 VNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKRARL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKRARL
               40        50        60        70        80        90

           310       320       330       340       350       360   
pF1KE0 AKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQL
              100       110       120       130       140       150

           370       380       390       400       410       420   
pF1KE0 QAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHGPFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHGPFG
              160       170       180       190       200       210

           430       440       450       460       470       480   
pF1KE0 HGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGK
              220       230       240       250       260       270

           490       500       510       520       530     
pF1KE0 IWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
              280       290       300       310       320  

>>NP_001310597 (OMIM: 604992) sarcalumenin isoform 2 [Ho  (431 aa)
 initn: 551 init1: 385 opt: 755  Z-score: 819.4  bits: 161.0 E(85289): 6.6e-39
Smith-Waterman score: 755; 33.9% identity (69.6% similar) in 375 aa overlap (13-377:6-377)

               10        20        30        40        50        60
pF1KE0 MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPM
                   :  . ...: . :.:.:.:.. :::. :...:...  . :... .:::
NP_001        MLNEDKPSDDYSAVLQRLRKIYHSSIKPLEQSYKYNELRQHEITDGEITSKPM
                      10        20        30        40        50   

               70          80        90       100       110        
pF1KE0 VLLVGQYSTGKTTFIRYLL--EQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDP
       ::..: .:.::.:.: :::  :.    .  : ::::. : ..:.:     : : ....: 
NP_001 VLFLGPWSVGKSTMINYLLGLENTRYQLYTGAEPTTSEFTVLMHGPKLKTIEGIVMAADS
            60        70        80        90       100       110   

      120       130       140       150       160       170        
pF1KE0 KKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWF
        . :  :. ::. ::....  ..:. .:: .. .:::::. ..::.  ::: :  : .::
NP_001 ARSFSPLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPGIIENRKQQ-ERGYPFNDVCQWF
           120       130       140       150        160       170  

      180       190       200       210       220       230        
pF1KE0 AERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMW
        .:.: :...::  :::.. :.  ... ::..:...:..:::::.. ::.::::::::.:
NP_001 IDRADLIFVVFDPTKLDVGLELEMLFRQLKGRESQIRIILNKADNLATQMLMRVYGALFW
            180       190       200       210       220       230  

      240       250       260       270       280       290        
pF1KE0 SLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLI
       ::. ..:. :  :::..::: .      ...::  :: .:..:.... .:    :.  . 
NP_001 SLAPLINVTEPPRVYVSSFWPQEYKPDTHQELFLQEEISLLEDLNQVIENRLENKIAFIR
            240       250       260       270       280       290  

      300       310           320         330         340       350
pF1KE0 KRARLAKVHAYIIS----SLKKEMPSVFGKDNKK--KELVNNLAE--IYGRIEREHQISP
       ..:  ...:: ...    . : .:  .: .:..   :..:..  .  :.  :  . ..: 
NP_001 QHAIRVRIHALLVDRYLQTYKDKM--TFFSDGELVFKDIVEDPDKFYIFKTILAKTNVSK
            300       310         320       330       340       350

              360       370       380       390       400       410
pF1KE0 GDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVK
        :.:: . ..: .  . .:.:. :...                                 
NP_001 FDLPNREAYKDFFGINPISSFKLLSQQCSYMGGCFLEKIERAITQELPGLLGSLGLGKNP
              360       370       380       390       400       410




535 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 03:30:17 2016 done: Fri Nov  4 03:30:18 2016
 Total Scan time:  8.830 Total Display time:  0.090

Function used was FASTA [36.3.4 Apr, 2011]
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