Result of FASTA (omim) for pF1KB3264
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3264, 847 aa
  1>>>pF1KB3264 847 - 847 aa - 847 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.3400+/-0.000663; mu= 1.5651+/- 0.040
 mean_var=386.6401+/-83.565, 0's: 0 Z-trim(114.5): 325  B-trim: 33 in 1/51
 Lambda= 0.065226
 statistics sampled from 24044 (24386) to 24044 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.286), width:  16
 Scan time: 12.710

The best scores are:                                      opt bits E(85289)
NP_006104 (OMIM: 605541) guanine nucleotide exchan ( 847) 5737 555.9 2.8e-157
XP_016855543 (OMIM: 605541) PREDICTED: guanine nuc ( 783) 5297 514.4 7.8e-145
XP_016855544 (OMIM: 605541) PREDICTED: guanine nuc ( 751) 4992 485.7 3.3e-136
XP_005270417 (OMIM: 605541) PREDICTED: guanine nuc ( 753) 4986 485.1 4.9e-136
XP_005270418 (OMIM: 605541) PREDICTED: guanine nuc ( 621) 3994 391.7 5.5e-108
XP_016855542 (OMIM: 605541) PREDICTED: guanine nuc ( 823) 3828 376.2 3.3e-103
NP_005419 (OMIM: 164875) proto-oncogene vav isofor ( 845) 3429 338.7 6.8e-92
XP_005259699 (OMIM: 164875) PREDICTED: proto-oncog ( 821) 3004 298.7 7.3e-80
XP_016855545 (OMIM: 605541) PREDICTED: guanine nuc ( 407) 2823 281.3 6.3e-75
NP_001127870 (OMIM: 600428) guanine nucleotide exc ( 878) 2675 267.8 1.6e-70
NP_001245135 (OMIM: 164875) proto-oncogene vav iso ( 823) 2674 267.6 1.6e-70
NP_001245136 (OMIM: 164875) proto-oncogene vav iso ( 813) 2416 243.3 3.3e-63
NP_003362 (OMIM: 600428) guanine nucleotide exchan ( 839) 2290 231.5 1.2e-59
XP_005272270 (OMIM: 600428) PREDICTED: guanine nuc ( 868) 2290 231.5 1.3e-59
XP_016870601 (OMIM: 600428) PREDICTED: guanine nuc ( 844) 2280 230.6 2.4e-59
XP_016870599 (OMIM: 600428) PREDICTED: guanine nuc ( 873) 2280 230.6 2.4e-59
XP_016870598 (OMIM: 600428) PREDICTED: guanine nuc ( 891) 1958 200.3 3.3e-50
XP_016870600 (OMIM: 600428) PREDICTED: guanine nuc ( 867) 1948 199.3 6.2e-50
XP_016870597 (OMIM: 600428) PREDICTED: guanine nuc ( 896) 1948 199.4 6.3e-50
NP_001073343 (OMIM: 605541) guanine nucleotide exc ( 287) 1914 195.5 2.9e-49
XP_016870602 (OMIM: 600428) PREDICTED: guanine nuc ( 620) 1767 182.1 6.7e-45
NP_001273724 (OMIM: 613324) spermatogenesis-associ ( 574)  363 50.0 3.8e-05
NP_001273723 (OMIM: 613324) spermatogenesis-associ ( 596)  363 50.0 3.9e-05
NP_694568 (OMIM: 613324) spermatogenesis-associate ( 652)  363 50.0 4.1e-05
XP_005263745 (OMIM: 605216) PREDICTED: rho guanine ( 483)  358 49.4 4.7e-05
XP_011509578 (OMIM: 605216) PREDICTED: rho guanine ( 483)  358 49.4 4.7e-05
XP_005263746 (OMIM: 605216) PREDICTED: rho guanine ( 483)  358 49.4 4.7e-05
XP_011509579 (OMIM: 605216) PREDICTED: rho guanine ( 483)  358 49.4 4.7e-05
XP_005263744 (OMIM: 605216) PREDICTED: rho guanine ( 567)  358 49.5 5.2e-05
NP_127462 (OMIM: 605216) rho guanine nucleotide ex ( 670)  358 49.6 5.8e-05
NP_056135 (OMIM: 605216) rho guanine nucleotide ex ( 690)  358 49.6 5.9e-05
NP_001159743 (OMIM: 613324) spermatogenesis-associ (1277)  363 50.4 6.2e-05
NP_001273721 (OMIM: 613324) spermatogenesis-associ (1339)  363 50.4 6.4e-05
XP_011509576 (OMIM: 605216) PREDICTED: rho guanine (1870)  358 50.2 0.00011
XP_005263738 (OMIM: 605216) PREDICTED: rho guanine (1876)  358 50.2 0.00011
XP_011529194 (OMIM: 300429,300607) PREDICTED: rho  ( 456)  340 47.7 0.00015
NP_001166950 (OMIM: 300429,300607) rho guanine nuc ( 463)  340 47.7 0.00015
XP_016884862 (OMIM: 300429,300607) PREDICTED: rho  ( 414)  335 47.1 0.00019
NP_001166951 (OMIM: 300429,300607) rho guanine nuc ( 414)  335 47.1 0.00019
NP_001273722 (OMIM: 613324) spermatogenesis-associ ( 512)  329 46.7 0.00032
XP_016874112 (OMIM: 617043) PREDICTED: rho guanine (1057)  322 46.4  0.0008
NP_055601 (OMIM: 617043) rho guanine nucleotide ex (2063)  323 46.9  0.0011
XP_006723397 (OMIM: 611893,616763) PREDICTED: plec (1327)  304 44.9   0.003
XP_005259220 (OMIM: 611893,616763) PREDICTED: plec (1386)  304 44.9   0.003
NP_073746 (OMIM: 611893,616763) pleckstrin homolog (1386)  304 44.9   0.003
XP_011525534 (OMIM: 611893,616763) PREDICTED: plec (1387)  304 44.9   0.003
XP_016882640 (OMIM: 611893,616763) PREDICTED: plec (1371)  302 44.7  0.0034
XP_016882639 (OMIM: 611893,616763) PREDICTED: plec (1374)  302 44.7  0.0034
XP_016884869 (OMIM: 300429,300607) PREDICTED: rho  ( 305)  285 42.3  0.0042
NP_002652 (OMIM: 600220,614468,614878) 1-phosphati (1265)  298 44.3  0.0043


>>NP_006104 (OMIM: 605541) guanine nucleotide exchange f  (847 aa)
 initn: 5737 init1: 5737 opt: 5737  Z-score: 2944.6  bits: 555.9 E(85289): 2.8e-157
Smith-Waterman score: 5737; 99.9% identity (100.0% similar) in 847 aa overlap (1-847:1-847)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
NP_006 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
              790       800       810       820       830       840

              
pF1KB3 TYVEEDE
       :::::::
NP_006 TYVEEDE
              

>>XP_016855543 (OMIM: 605541) PREDICTED: guanine nucleot  (783 aa)
 initn: 5297 init1: 5297 opt: 5297  Z-score: 2721.2  bits: 514.4 E(85289): 7.8e-145
Smith-Waterman score: 5297; 99.9% identity (100.0% similar) in 783 aa overlap (1-783:1-783)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
       :::                                                         
XP_016 GNS                                                         
                                                                   

>>XP_016855544 (OMIM: 605541) PREDICTED: guanine nucleot  (751 aa)
 initn: 4992 init1: 4992 opt: 4992  Z-score: 2566.3  bits: 485.7 E(85289): 3.3e-136
Smith-Waterman score: 4992; 99.9% identity (100.0% similar) in 741 aa overlap (107-847:11-751)

         80        90       100       110       120       130      
pF1KB3 TFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESIN
                                     ::::::::::::::::::::::::::::::
XP_016                     MMMRMMTMTTKVIETLSRLSRTPIALATGIRPFPTEESIN
                                   10        20        30        40

        140       150       160       170       180       190      
pF1KB3 DEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCC
               50        60        70        80        90       100

        200       210       220       230       240       250      
pF1KB3 LAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSI
              110       120       130       140       150       160

        260       270       280       290       300       310      
pF1KB3 VNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNG
       :::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_016 VNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNG
              170       180       190       200       210       220

        320       330       340       350       360       370      
pF1KB3 KFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNE
              230       240       250       260       270       280

        380       390       400       410       420       430      
pF1KB3 TLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKG
              290       300       310       320       330       340

        440       450       460       470       480       490      
pF1KB3 DNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQ
              350       360       370       380       390       400

        500       510       520       530       540       550      
pF1KB3 FEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECL
              410       420       430       440       450       460

        560       570       580       590       600       610      
pF1KB3 GRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPP
              470       480       490       500       510       520

        620       630       640       650       660       670      
pF1KB3 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA
              530       540       550       560       570       580

        680       690       700       710       720       730      
pF1KB3 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF
              590       600       610       620       630       640

        740       750       760       770       780       790      
pF1KB3 KSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIAR
              650       660       670       680       690       700

        800       810       820       830       840       
pF1KB3 YDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
              710       720       730       740       750 

>>XP_005270417 (OMIM: 605541) PREDICTED: guanine nucleot  (753 aa)
 initn: 4986 init1: 4986 opt: 4986  Z-score: 2563.2  bits: 485.1 E(85289): 4.9e-136
Smith-Waterman score: 4986; 99.9% identity (100.0% similar) in 740 aa overlap (108-847:14-753)

        80        90       100       110       120       130       
pF1KB3 FLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESIND
                                     ::::::::::::::::::::::::::::::
XP_005                  MQLPDCPCRAHLPVIETLSRLSRTPIALATGIRPFPTEESIND
                                10        20        30        40   

       140       150       160       170       180       190       
pF1KB3 EDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCL
            50        60        70        80        90       100   

       200       210       220       230       240       250       
pF1KB3 AEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIV
           110       120       130       140       150       160   

       260       270       280       290       300       310       
pF1KB3 NKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGK
       ::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_005 NKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGK
           170       180       190       200       210       220   

       320       330       340       350       360       370       
pF1KB3 FTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNET
           230       240       250       260       270       280   

       380       390       400       410       420       430       
pF1KB3 LREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGD
           290       300       310       320       330       340   

       440       450       460       470       480       490       
pF1KB3 NYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQF
           350       360       370       380       390       400   

       500       510       520       530       540       550       
pF1KB3 EMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLG
           410       420       430       440       450       460   

       560       570       580       590       600       610       
pF1KB3 RVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPL
           470       480       490       500       510       520   

       620       630       640       650       660       670       
pF1KB3 QLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAM
           530       540       550       560       570       580   

       680       690       700       710       720       730       
pF1KB3 ERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFK
           590       600       610       620       630       640   

       740       750       760       770       780       790       
pF1KB3 SLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARY
           650       660       670       680       690       700   

       800       810       820       830       840       
pF1KB3 DFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
           710       720       730       740       750   

>>XP_005270418 (OMIM: 605541) PREDICTED: guanine nucleot  (621 aa)
 initn: 4060 init1: 3994 opt: 3994  Z-score: 2059.6  bits: 391.7 E(85289): 5.5e-108
Smith-Waterman score: 3994; 99.5% identity (99.8% similar) in 595 aa overlap (1-595:1-595)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_005 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
       :::::::::::::::::::::::::::::::::::::::::::::::::::: .:     
XP_005 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPDVPCLLHF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
                                                                   
XP_005 FISMAPATRSIVKSQKKNKKF                                       
              610       620                                        

>>XP_016855542 (OMIM: 605541) PREDICTED: guanine nucleot  (823 aa)
 initn: 5562 init1: 3823 opt: 3828  Z-score: 1973.9  bits: 376.2 E(85289): 3.3e-103
Smith-Waterman score: 5518; 97.0% identity (97.2% similar) in 847 aa overlap (1-847:1-823)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
       ::::::::::::::::::::::::::::                        ::::::::
XP_016 GYLCFKCGARAHKECLGRVDNCGRVNSG------------------------GLPKMQVI
              550       560                               570      

              610       620       630       640       650       660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
        580       590       600       610       620       630      

              670       680       690       700       710       720
pF1KB3 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
        640       650       660       670       680       690      

              730       740       750       760       770       780
pF1KB3 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
        700       710       720       730       740       750      

              790       800       810       820       830       840
pF1KB3 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
        760       770       780       790       800       810      

              
pF1KB3 TYVEEDE
       :::::::
XP_016 TYVEEDE
        820   

>>NP_005419 (OMIM: 164875) proto-oncogene vav isoform 1   (845 aa)
 initn: 3081 init1: 1631 opt: 3429  Z-score: 1770.8  bits: 338.7 E(85289): 6.8e-92
Smith-Waterman score: 3429; 58.7% identity (82.6% similar) in 849 aa overlap (1-846:1-840)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       :: :.::..:::.:.::: .::::::.::: .:::.::::::::::::::  :.:::.:.
NP_005 MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       :::::::::::::::::::..::: ::...::::::::::::.:::::: ::: :: :::
NP_005 NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
               70        80        90       100       110       120

              130        140       150       160        170        
pF1KB3 ALATGIRPFPTEE-SINDEDIYKGLPDLIDETLVEDEEDLYDCVYGED-EGGEVYEDLMK
       :   :: :::::: :..:::::.:: : ::.: ::..::::::: .:. :: :.:::::.
NP_005 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDT-VEEDEDLYDCVENEEAEGDEIYEDLMR
              130       140       150        160       170         

      180        190       200       210       220       230       
pF1KB3 AEEAHQP-KCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN
       .: . .: :  : : : ::: ::.:::::::.:: ::...:. ::.:::   ... .:::
NP_005 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFIN
     180       190       200       210       220       230         

       240       250       260       270       280       290       
pF1KB3 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK
       : .:...: ....:..... . .  :::::::.::::...::.::: :::: . :: .. 
NP_005 IEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAA
     240       250       260       270       280       290         

       300       310       320       330       340       350       
pF1KB3 SKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA
       ..:::..::::::.:::::.:::::::.:::::::::::::::::::: .  :: ::.::
NP_005 AREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLA
     300       310       320       330       340       350         

       360       370       380       390       400       410       
pF1KB3 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK
       ::::.:::: ::::::::::::.: .::::::::.: .  .:::. :::..::......:
NP_005 LDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSK
     360       370       380       390       400       410         

       420       430       440       450       460       470       
pF1KB3 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ
       ..:. ::.: :...:::.::.:..:....:..... .. . :..:::::. : ::. :: 
NP_005 MDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGA
     420       430       440       450       460       470         

       480       490       500       510       520       530       
pF1KB3 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT
       .: :.. ::..:::::.::::::.::: :. : .: :::.: .: ..::::.::::::::
NP_005 QGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGT
     480       490       500       510       520       530         

       540       550       560       570       580       590       
pF1KB3 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM
       ::::: : .: : :::::::::  ::: ..   ::.:  . . .   .  :. . :::::
NP_005 FYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMK--KDKLHRRAQDKKRNELGLPKM
     540       550       560       570         580       590       

       600       610       620       630       640       650       
pF1KB3 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP
       .:...: : :::    :: :.:. :: ::: :..:.. .:.::: ...:.:.:: . :::
NP_005 EVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKP
       600       610       620       630       640       650       

       660       670       680       690       700       710       
pF1KB3 CPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAK
           : : : : . :::: :::  ::. : :: ..:.:::.:.:...:.::::::: :.:
NP_005 YVHGP-PQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVK
       660        670       680       690       700       710      

       720       730       740       750       760       770       
pF1KB3 HIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG
       ::::.: .:...:.:.. :..: ::::.:...:::. :..::::::::.::::. . .: 
NP_005 HIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRP
        720       730       740       750       760       770      

       780       790       800       810       820       830       
pF1KB3 NRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGW
            .. : : .: : :::::::::  :::: .::..:: .: . .::::::. :::::
NP_005 -----AVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGW
             780       790       800       810       820       830 

       840           
pF1KB3 FPSTYVEEDE    
       ::..:::::     
NP_005 FPANYVEEDYSEYC
             840     

>>XP_005259699 (OMIM: 164875) PREDICTED: proto-oncogene   (821 aa)
 initn: 2633 init1: 1631 opt: 3004  Z-score: 1554.8  bits: 298.7 E(85289): 7.3e-80
Smith-Waterman score: 3004; 58.8% identity (83.0% similar) in 742 aa overlap (1-739:1-738)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       :: :.::..:::.:.::: .::::::.::: .:::.::::::::::::::  :.:::.:.
XP_005 MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       :::::::::::::::::::..::: ::...::::::::::::.:::::: ::: :: :::
XP_005 NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
               70        80        90       100       110       120

              130        140       150       160        170        
pF1KB3 ALATGIRPFPTEE-SINDEDIYKGLPDLIDETLVEDEEDLYDCVYGED-EGGEVYEDLMK
       :   :: :::::: :..:::::.:: : ::.: ::..::::::: .:. :: :.:::::.
XP_005 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDT-VEEDEDLYDCVENEEAEGDEIYEDLMR
              130       140       150        160       170         

      180        190       200       210       220       230       
pF1KB3 AEEAHQP-KCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN
       .: . .: :  : : : ::: ::.:::::::.:: ::...:. ::.:::   ... .:::
XP_005 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFIN
     180       190       200       210       220       230         

       240       250       260       270       280       290       
pF1KB3 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK
       : .:...: ....:..... . .  :::::::.::::...::.::: :::: . :: .. 
XP_005 IEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAA
     240       250       260       270       280       290         

       300       310       320       330       340       350       
pF1KB3 SKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA
       ..:::..::::::.:::::.:::::::.:::::::::::::::::::: .  :: ::.::
XP_005 AREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLA
     300       310       320       330       340       350         

       360       370       380       390       400       410       
pF1KB3 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK
       ::::.:::: ::::::::::::.: .::::::::.: .  .:::. :::..::......:
XP_005 LDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSK
     360       370       380       390       400       410         

       420       430       440       450       460       470       
pF1KB3 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ
       ..:. ::.: :...:::.::.:..:....:..... .. . :..:::::. : ::. :: 
XP_005 MDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGA
     420       430       440       450       460       470         

       480       490       500       510       520       530       
pF1KB3 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT
       .: :.. ::..:::::.::::::.::: :. : .: :::.: .: ..::::.::::::::
XP_005 QGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGT
     480       490       500       510       520       530         

       540       550       560       570       580       590       
pF1KB3 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM
       ::::: : .: : :::::::::  ::: ..   ::.:  . . .   .  :. . :::::
XP_005 FYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMK--KDKLHRRAQDKKRNELGLPKM
     540       550       560       570         580       590       

       600       610       620       630       640       650       
pF1KB3 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP
       .:...: : :::    :: :.:. :: ::: :..:.. .:.::: ...:.:.:: . :::
XP_005 EVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKP
       600       610       620       630       640       650       

       660       670       680       690       700       710       
pF1KB3 CPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAK
           : : : : . :::: :::  ::. : :: ..:.:::.:.:...:.::::::: :.:
XP_005 YVHGP-PQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVK
       660        670       680       690       700       710      

       720       730       740       750       760       770       
pF1KB3 HIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG
       ::::.: .:...:.:.. :..:                                      
XP_005 HIKIMTAEGLYRITEKKAFRGLTWEAQSILAQPKPAMTSAPETDQSCRSRRVTSSRSLTR
        720       730       740       750       760       770      

>>XP_016855545 (OMIM: 605541) PREDICTED: guanine nucleot  (407 aa)
 initn: 2823 init1: 2823 opt: 2823  Z-score: 1466.1  bits: 281.3 E(85289): 6.3e-75
Smith-Waterman score: 2823; 100.0% identity (100.0% similar) in 407 aa overlap (441-847:1-407)

              420       430       440       450       460       470
pF1KB3 TLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFY
                                     ::::::::::::::::::::::::::::::
XP_016                               MKEIIDLQQYKIANNPTTDKENKKWSYGFY
                                             10        20        30

              480       490       500       510       520       530
pF1KB3 LIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVC
               40        50        60        70        80        90

              540       550       560       570       580       590
pF1KB3 QMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQV
              100       110       120       130       140       150

              600       610       620       630       640       650
pF1KB3 DPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFF
              160       170       180       190       200       210

              660       670       680       690       700       710
pF1KB3 PSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISI
              220       230       240       250       260       270

              720       730       740       750       760       770
pF1KB3 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPE
              280       290       300       310       320       330

              780       790       800       810       820       830
pF1KB3 HSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGE
              340       350       360       370       380       390

              840       
pF1KB3 VNGRVGWFPSTYVEEDE
       :::::::::::::::::
XP_016 VNGRVGWFPSTYVEEDE
              400       

>>NP_001127870 (OMIM: 600428) guanine nucleotide exchang  (878 aa)
 initn: 2588 init1: 766 opt: 2675  Z-score: 1387.2  bits: 267.8 E(85289): 1.6e-70
Smith-Waterman score: 3105; 52.1% identity (76.8% similar) in 898 aa overlap (1-846:1-875)

               10        20        30        40        50        60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
       :: :.::..::: ::::: ::::.: :: ::::::.:::::::::::.::   ::.::.:
NP_001 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
       :.::::::::::::::::: .: . ::.:.::::. ::::::::::::: ..::::   :
NP_001 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
               70        80        90       100       110       120

              130        140       150       160       170         
pF1KB3 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA
       :   ::::::.::.  ::.:.:..: .: ::   .  ::.::::  :: : ..:::..:.
NP_001 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV
              130       140       150         160       170        

     180               190       200       210       220       230 
pF1KB3 EEAHQPKC--------PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEF
       : ..::           :.: :.::: ::..:: :: .:::.::: .:.::.  :. :..
NP_001 E-VQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADM
       180       190       200       210       220       230       

             240       250       260       270       280       290 
pF1KB3 DSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISS
        .::::. .:.:.:..... : :  :  . ..: .::...::::.:::.::: .: : ..
NP_001 AAVFINLEDLIKVHHSFLRAI-DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT
       240       250        260       270       280       290      

             300       310       320       330       340       350 
pF1KB3 LDYISKSKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK
       :. .  :.:: . :.:::. ....::: :.:::::::::::::::::.::..:...  :.
NP_001 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPER
        300       310       320       330       340       350      

             360       370       380       390       400       410 
pF1KB3 ANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITT
        .:: ::.::.:::.:.::::::.::::.:..:: :::::.  .  ::::. :::... .
NP_001 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS
        360       370       380       390       400       410      

             420       430       440       450       460           
pF1KB3 LDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKK-----WS
       . .::::.:..:::: .:::::::: .::.::::.:  .:....: ..:. ::     ::
NP_001 IVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWS
        420       430       440       450       460       470      

        470       480       490       500       510       520      
pF1KB3 YGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTS
       ::::::: ::..:..:.:::.:.:.::.::::::.:::.:: :..: :.:.:.:: ..:.
NP_001 YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTN
        480       490       500       510       520       530      

        530       540       550       560       570       580      
pF1KB3 CKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRT
       ::.:.:.:::::::::.: :::. ::::::  .  :               : :.     
NP_001 CKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPC---------------KFTSPADLD
        540       550       560       570                      580 

        590       600       610        620       630       640     
pF1KB3 PKQVDPGLPKMQVIRNYSGTPPPALHEGPP-LQLQAGDTVELLKGDAHSLFWQGRNLASG
        . . :: ::: ...:: :.: :    : : : .:.::..:::.:: .: .:.:: . . 
NP_001 ASGAGPG-PKMVAMQNYHGNPAPP---GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTR
              590       600          610       620       630       

         650       660                670       680       690      
pF1KB3 EVGFFPSDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLV
       . :.:::..:::::   .:         .::.  ::.:: ::: :... : .....:::.
NP_001 KSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLI
       640       650       660       670       680       690       

        700       710       720       730       740       750      
pF1KB3 RHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFR
       :.:  :. ..:::::.:.:.::::.. .:...::.: .:: ::.::::::. :::::.:.
NP_001 RERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFK
       700       710       720       730       740       750       

        760       770       780                                    
pF1KB3 TLDTTLQFPYKEPEHSAGQRGNRAGNS---------------------------LLSPKV
        :::::..:::  :.::.. ..:.  :                           ...:.:
NP_001 QLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRV
       760       770       780       790       800       810       

     790       800       810       820        830       840        
pF1KB3 LGIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPSTYVEEDE 
       .: :.:::.: ::::::::: .::::.::...... :::.::.:::.::::::::::.  
NP_001 IGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGI
       820       830       840       850       860       870       

NP_001 Q
        




847 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 01:05:16 2016 done: Sat Nov  5 01:05:18 2016
 Total Scan time: 12.710 Total Display time:  0.280

Function used was FASTA [36.3.4 Apr, 2011]
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