Result of FASTA (ccds) for pF1KB5356
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5356, 448 aa
  1>>>pF1KB5356 448 - 448 aa - 448 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.7129+/-0.000803; mu= 16.6642+/- 0.048
 mean_var=83.8769+/-16.984, 0's: 0 Z-trim(109.3): 14  B-trim: 364 in 1/52
 Lambda= 0.140040
 statistics sampled from 10800 (10810) to 10800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.332), width:  16
 Scan time:  2.840

The best scores are:                                      opt bits E(32554)
CCDS1556.1 PSEN2 gene_id:5664|Hs108|chr1           ( 448) 2979 611.5 5.5e-175
CCDS44324.1 PSEN2 gene_id:5664|Hs108|chr1          ( 447) 2961 607.9 6.8e-174
CCDS9813.1 PSEN1 gene_id:5663|Hs108|chr14          ( 463) 1309 274.1 2.1e-73
CCDS9812.1 PSEN1 gene_id:5663|Hs108|chr14          ( 467) 1309 274.1 2.1e-73


>>CCDS1556.1 PSEN2 gene_id:5664|Hs108|chr1                (448 aa)
 initn: 2979 init1: 2979 opt: 2979  Z-score: 3255.1  bits: 611.5 E(32554): 5.5e-175
Smith-Waterman score: 2979; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448)

               10        20        30        40        50        60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS15 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
              370       380       390       400       410       420

              430       440        
pF1KB5 TFGLIFYFSTDNLVRPFMDTLASHQLYI
       ::::::::::::::::::::::::::::
CCDS15 TFGLIFYFSTDNLVRPFMDTLASHQLYI
              430       440        

>>CCDS44324.1 PSEN2 gene_id:5664|Hs108|chr1               (447 aa)
 initn: 2164 init1: 2164 opt: 2961  Z-score: 3235.4  bits: 607.9 E(32554): 6.8e-174
Smith-Waterman score: 2961; 99.8% identity (99.8% similar) in 448 aa overlap (1-448:1-447)

               10        20        30        40        50        60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 DRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 YTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 FLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 LVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVW
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 TVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
       :::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
CCDS44 TVGMAKLDPSSQGALQLPYDPEME-DSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGV
              310       320        330       340       350         

              370       380       390       400       410       420
pF1KB5 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 KLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISI
     360       370       380       390       400       410         

              430       440        
pF1KB5 TFGLIFYFSTDNLVRPFMDTLASHQLYI
       ::::::::::::::::::::::::::::
CCDS44 TFGLIFYFSTDNLVRPFMDTLASHQLYI
     420       430       440       

>>CCDS9813.1 PSEN1 gene_id:5663|Hs108|chr14               (463 aa)
 initn: 1828 init1: 1291 opt: 1309  Z-score: 1431.4  bits: 274.1 E(32554): 2.1e-73
Smith-Waterman score: 1821; 65.3% identity (79.3% similar) in 464 aa overlap (24-448:3-463)

               10        20        30        40        50        60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
                              : :.: :  .. :  ::.. .    ...:.:  :.. 
CCDS98                      MTELPAPLSYFQNAQMSEDNHLSN---TNDNRERQEHND
                                    10        20           30      

                  70                   80        90       100      
pF1KB5 DRYVCSGVP---GRPPG-----------LEEELTLKYGAKHVIMLFVPVTLCMIVVVATI
        : .    :   ::: :            .:::::::::::::::::::::::.::::::
CCDS98 RRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI
         40        50        60        70        80        90      

        110       120       130       140       150       160      
pF1KB5 KSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYK
       ::: :::.:.:::::::::::: .:::: :.:.::. :::::::::::.:::::::::::
CCDS98 KSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYK
        100       110       120       130       140       150      

        170       180       190       200       210       220      
pF1KB5 FIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLV
        ::.:::.:::.:::.:..::::::.::::::.:: :. : .::::.:::. ::::::: 
CCDS98 VIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLR
        160       170       180       190       200       210      

        230       240       250       260       270       280      
pF1KB5 LQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNE
       ::::::::::::::::::::::::.::.::..::::::::::::::::::::::::::::
CCDS98 LQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNE
        220       230       240       250       260       270      

        290       300       310         320        330          340
pF1KB5 PIFPALIYSSAMVWTVGMAKLDPSSQGALQL--PYDPE-MEEDSYDSFGEPS---YPEVF
        .::::::::.::: :.::. :: .:  ..    :. :  :..: :. .: .   . : .
CCDS98 TLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEW
        280       290       300       310       320       330      

                          350              360       370       380 
pF1KB5 EPPLTGYPG------------EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAATG
       :    .. :            .::       :. ::::::::::::::::::::::.::.
CCDS98 EAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATA
        340       350       360       370       380       390      

             390       400       410       420       430       440 
pF1KB5 SGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTL
       :::::::.::::::::::::::::::.::::::::::::::::.:::.:: ::.:::: :
CCDS98 SGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQL
        400       410       420       430       440       450      

              
pF1KB5 ASHQLYI
       : ::.::
CCDS98 AFHQFYI
        460   

>>CCDS9812.1 PSEN1 gene_id:5663|Hs108|chr14               (467 aa)
 initn: 1864 init1: 1291 opt: 1309  Z-score: 1431.3  bits: 274.1 E(32554): 2.1e-73
Smith-Waterman score: 1841; 65.7% identity (79.4% similar) in 466 aa overlap (24-448:3-467)

               10        20        30        40        50        60
pF1KB5 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
                              : :.: :  .. :  ::.. .   :::..... .:  
CCDS98                      MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHN
                                    10        20        30         

                    70                   80        90       100    
pF1KB5 DRYVCSGVP-----GRPPG-----------LEEELTLKYGAKHVIMLFVPVTLCMIVVVA
       ::    : :     ::: :            .:::::::::::::::::::::::.::::
CCDS98 DRRSL-GHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVA
      40         50        60        70        80        90        

          110       120       130       140       150       160    
pF1KB5 TIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRC
       ::::: :::.:.:::::::::::: .:::: :.:.::. :::::::::::.:::::::::
CCDS98 TIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRC
      100       110       120       130       140       150        

          170       180       190       200       210       220    
pF1KB5 YKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGP
       :: ::.:::.:::.:::.:..::::::.::::::.:: :. : .::::.:::. ::::::
CCDS98 YKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGP
      160       170       180       190       200       210        

          230       240       250       260       270       280    
pF1KB5 LVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQER
       : ::::::::::::::::::::::::.::.::..::::::::::::::::::::::::::
CCDS98 LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQER
      220       230       240       250       260       270        

          290       300       310         320        330           
pF1KB5 NEPIFPALIYSSAMVWTVGMAKLDPSSQGALQL--PYDPE-MEEDSYDSFGEPS---YPE
       :: .::::::::.::: :.::. :: .:  ..    :. :  :..: :. .: .   . :
CCDS98 NETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSE
      280       290       300       310       320       330        

      340                   350              360       370         
pF1KB5 VFEPPLTGYPG------------EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAA
        .:    .. :            .::       :. ::::::::::::::::::::::.:
CCDS98 EWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASA
      340       350       360       370       380       390        

     380       390       400       410       420       430         
pF1KB5 TGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMD
       :.:::::::.::::::::::::::::::.::::::::::::::::.:::.:: ::.::::
CCDS98 TASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMD
      400       410       420       430       440       450        

     440        
pF1KB5 TLASHQLYI
        :: ::.::
CCDS98 QLAFHQFYI
      460       




448 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 21:48:57 2016 done: Fri Nov  4 21:48:58 2016
 Total Scan time:  2.840 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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