FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8910, 208 aa 1>>>pF1KB8910 208 - 208 aa - 208 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3746+/-0.000329; mu= 13.1876+/- 0.020 mean_var=69.1491+/-13.898, 0's: 0 Z-trim(115.7): 74 B-trim: 290 in 1/52 Lambda= 0.154234 statistics sampled from 26300 (26388) to 26300 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.309), width: 16 Scan time: 6.250 The best scores are: opt bits E(85289) NP_003815 (OMIM: 602457,613759) FAS-associated dea ( 208) 1347 308.3 5.6e-84 XP_016866893 (OMIM: 603453) PREDICTED: receptor-in ( 382) 154 43.0 0.00076 XP_016866892 (OMIM: 603453) PREDICTED: receptor-in ( 508) 154 43.1 0.00096 NP_001303990 (OMIM: 603453) receptor-interacting s ( 508) 154 43.1 0.00096 XP_005249514 (OMIM: 603453) PREDICTED: receptor-in ( 671) 154 43.2 0.0012 NP_003795 (OMIM: 603453) receptor-interacting seri ( 671) 154 43.2 0.0012 XP_006712856 (OMIM: 114480,114550,211980,601763,60 ( 235) 147 41.3 0.0015 NP_203522 (OMIM: 114480,114550,211980,601763,60727 ( 235) 147 41.3 0.0015 XP_005246952 (OMIM: 114480,114550,211980,601763,60 ( 279) 147 41.4 0.0017 XP_005246950 (OMIM: 114480,114550,211980,601763,60 ( 294) 147 41.4 0.0018 XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 147 41.5 0.0026 NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 147 41.5 0.0026 NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 147 41.5 0.0026 XP_005246947 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 XP_005246943 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 147 41.5 0.0027 XP_005246945 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 147 41.5 0.0027 NP_001219 (OMIM: 114480,114550,211980,601763,60727 ( 496) 147 41.5 0.0028 XP_005246942 (OMIM: 114480,114550,211980,601763,60 ( 523) 147 41.5 0.0029 NP_001073594 (OMIM: 114480,114550,211980,601763,60 ( 538) 147 41.6 0.003 NP_001293012 (OMIM: 601762,603909,605027,613659) c ( 247) 142 40.2 0.0034 XP_011510292 (OMIM: 601762,603909,605027,613659) P ( 272) 142 40.3 0.0036 NP_116758 (OMIM: 601762,603909,605027,613659) casp ( 273) 142 40.3 0.0036 NP_001193453 (OMIM: 601762,603909,605027,613659) c ( 455) 142 40.4 0.0056 NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 142 40.4 0.0058 NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 142 40.4 0.0058 XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 142 40.4 0.0062 NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 142 40.4 0.0062 NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 142 40.4 0.0062 >>NP_003815 (OMIM: 602457,613759) FAS-associated death d (208 aa) initn: 1347 init1: 1347 opt: 1347 Z-score: 1628.6 bits: 308.3 E(85289): 5.6e-84 Smith-Waterman score: 1347; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KB8 MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEV 130 140 150 160 170 180 190 200 pF1KB8 QQARDLQNRSGAMSPMSWNSDASTSEAS :::::::::::::::::::::::::::: NP_003 QQARDLQNRSGAMSPMSWNSDASTSEAS 190 200 >>XP_016866893 (OMIM: 603453) PREDICTED: receptor-intera (382 aa) initn: 127 init1: 82 opt: 154 Z-score: 190.1 bits: 43.0 E(85289): 0.00076 Smith-Waterman score: 154; 35.8% identity (69.1% similar) in 81 aa overlap (104-181:301-381) 80 90 100 110 120 130 pF1KB8 DLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRY : .:.:: :. ::.: ....:: :. : XP_016 TNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDY 280 290 300 310 320 330 140 150 160 170 180 190 pF1KB8 PRN-LTERVRESLRIWKNTEK-ENATVAHLVGALRSC-QMNLVADLVQEVQQARDLQNRS :. : :.: . :. : : ..:::..:. ::..: ...:...:. : XP_016 ERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN 340 350 360 370 380 200 pF1KB8 GAMSPMSWNSDASTSEAS >>XP_016866892 (OMIM: 603453) PREDICTED: receptor-intera (508 aa) initn: 129 init1: 82 opt: 154 Z-score: 188.2 bits: 43.1 E(85289): 0.00096 Smith-Waterman score: 154; 35.8% identity (69.1% similar) in 81 aa overlap (104-181:427-507) 80 90 100 110 120 130 pF1KB8 DLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRY : .:.:: :. ::.: ....:: :. : XP_016 TNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDY 400 410 420 430 440 450 140 150 160 170 180 190 pF1KB8 PRN-LTERVRESLRIWKNTEK-ENATVAHLVGALRSC-QMNLVADLVQEVQQARDLQNRS :. : :.: . :. : : ..:::..:. ::..: ...:...:. : XP_016 ERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN 460 470 480 490 500 200 pF1KB8 GAMSPMSWNSDASTSEAS >>NP_001303990 (OMIM: 603453) receptor-interacting serin (508 aa) initn: 129 init1: 82 opt: 154 Z-score: 188.2 bits: 43.1 E(85289): 0.00096 Smith-Waterman score: 154; 35.8% identity (69.1% similar) in 81 aa overlap (104-181:427-507) 80 90 100 110 120 130 pF1KB8 DLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRY : .:.:: :. ::.: ....:: :. : NP_001 TNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDY 400 410 420 430 440 450 140 150 160 170 180 190 pF1KB8 PRN-LTERVRESLRIWKNTEK-ENATVAHLVGALRSC-QMNLVADLVQEVQQARDLQNRS :. : :.: . :. : : ..:::..:. ::..: ...:...:. : NP_001 ERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN 460 470 480 490 500 200 pF1KB8 GAMSPMSWNSDASTSEAS >>XP_005249514 (OMIM: 603453) PREDICTED: receptor-intera (671 aa) initn: 109 init1: 82 opt: 154 Z-score: 186.4 bits: 43.2 E(85289): 0.0012 Smith-Waterman score: 154; 35.8% identity (69.1% similar) in 81 aa overlap (104-181:590-670) 80 90 100 110 120 130 pF1KB8 DLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRY : .:.:: :. ::.: ....:: :. : XP_005 TNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDY 560 570 580 590 600 610 140 150 160 170 180 190 pF1KB8 PRN-LTERVRESLRIWKNTEK-ENATVAHLVGALRSC-QMNLVADLVQEVQQARDLQNRS :. : :.: . :. : : ..:::..:. ::..: ...:...:. : XP_005 ERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN 620 630 640 650 660 670 200 pF1KB8 GAMSPMSWNSDASTSEAS >>NP_003795 (OMIM: 603453) receptor-interacting serine/t (671 aa) initn: 109 init1: 82 opt: 154 Z-score: 186.4 bits: 43.2 E(85289): 0.0012 Smith-Waterman score: 154; 35.8% identity (69.1% similar) in 81 aa overlap (104-181:590-670) 80 90 100 110 120 130 pF1KB8 DLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRY : .:.:: :. ::.: ....:: :. : NP_003 TNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDY 560 570 580 590 600 610 140 150 160 170 180 190 pF1KB8 PRN-LTERVRESLRIWKNTEK-ENATVAHLVGALRSC-QMNLVADLVQEVQQARDLQNRS :. : :.: . :. : : ..:::..:. ::..: ...:...:. : NP_003 ERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN 620 630 640 650 660 670 200 pF1KB8 GAMSPMSWNSDASTSEAS >>XP_006712856 (OMIM: 114480,114550,211980,601763,607271 (235 aa) initn: 146 init1: 146 opt: 147 Z-score: 184.8 bits: 41.3 E(85289): 0.0015 Smith-Waterman score: 147; 39.5% identity (67.1% similar) in 76 aa overlap (1-76:1-75) 10 20 30 40 50 60 pF1KB8 MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHT :: : :.... .:.: .:. :::: : . .:: : ....: ::. : :. :: .. XP_006 MD-FSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 ELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLK .:.::: . : ::: XP_006 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 60 70 80 90 100 110 >>NP_203522 (OMIM: 114480,114550,211980,601763,607271) c (235 aa) initn: 146 init1: 146 opt: 147 Z-score: 184.8 bits: 41.3 E(85289): 0.0015 Smith-Waterman score: 147; 39.5% identity (67.1% similar) in 76 aa overlap (1-76:1-75) 10 20 30 40 50 60 pF1KB8 MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHT :: : :.... .:.: .:. :::: : . .:: : ....: ::. : :. :: .. NP_203 MD-FSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 ELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLK .:.::: . : ::: NP_203 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 60 70 80 90 100 110 >>XP_005246952 (OMIM: 114480,114550,211980,601763,607271 (279 aa) initn: 146 init1: 146 opt: 147 Z-score: 183.7 bits: 41.4 E(85289): 0.0017 Smith-Waterman score: 147; 39.5% identity (67.1% similar) in 76 aa overlap (1-76:60-134) 10 20 30 pF1KB8 MDPFLVLLHSVSSSLSSSELTELKFLCLGR :: : :.... .:.: .:. :::: : XP_005 HVELGRLGDSETAMVPGKGGADYILLPFKKMD-FSRNLYDIGEQLDSEDLASLKFLSLDY 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB8 VGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGA . .:: : ....: ::. : :. :: .. .:.::: . : ::: XP_005 IPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB8 APGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKN XP_005 LQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKR 150 160 170 180 190 200 >>XP_005246950 (OMIM: 114480,114550,211980,601763,607271 (294 aa) initn: 146 init1: 146 opt: 147 Z-score: 183.3 bits: 41.4 E(85289): 0.0018 Smith-Waterman score: 147; 39.5% identity (67.1% similar) in 76 aa overlap (1-76:60-134) 10 20 30 pF1KB8 MDPFLVLLHSVSSSLSSSELTELKFLCLGR :: : :.... .:.: .:. :::: : XP_005 HVELGRLGDSETAMVPGKGGADYILLPFKKMD-FSRNLYDIGEQLDSEDLASLKFLSLDY 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB8 VGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGA . .:: : ....: ::. : :. :: .. .:.::: . : ::: XP_005 IPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB8 APGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKN XP_005 LQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKR 150 160 170 180 190 200 208 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:00:35 2016 done: Sat Nov 5 20:00:36 2016 Total Scan time: 6.250 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]