Result of FASTA (omim) for pF1KB9947
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9947, 531 aa
  1>>>pF1KB9947 531 - 531 aa - 531 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0660+/-0.000433; mu= 19.5101+/- 0.027
 mean_var=68.3804+/-13.737, 0's: 0 Z-trim(108.8): 36  B-trim: 713 in 1/52
 Lambda= 0.155099
 statistics sampled from 16851 (16880) to 16851 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.555), E-opt: 0.2 (0.198), width:  16
 Scan time:  9.240

The best scores are:                                      opt bits E(85289)
NP_002645 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 3465 785.1       0
XP_005254502 (OMIM: 179050) PREDICTED: pyruvate ki ( 531) 3465 785.1       0
XP_011519972 (OMIM: 179050) PREDICTED: pyruvate ki ( 566) 3465 785.1       0
XP_005254500 (OMIM: 179050) PREDICTED: pyruvate ki ( 591) 3465 785.2       0
XP_006720633 (OMIM: 179050) PREDICTED: pyruvate ki ( 605) 3465 785.2       0
XP_016877802 (OMIM: 179050) PREDICTED: pyruvate ki ( 531) 3325 753.8 2.9e-217
NP_872271 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 3325 753.8 2.9e-217
NP_872270 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 3325 753.8 2.9e-217
NP_001193728 (OMIM: 179050) pyruvate kinase PKM is ( 536) 3325 753.8 2.9e-217
NP_001303247 (OMIM: 179050) pyruvate kinase PKM is ( 566) 3325 753.8 3.1e-217
NP_001193725 (OMIM: 179050) pyruvate kinase PKM is ( 605) 3325 753.8 3.2e-217
NP_001193727 (OMIM: 179050) pyruvate kinase PKM is ( 516) 2923 663.8 3.4e-190
NP_001193726 (OMIM: 179050) pyruvate kinase PKM is ( 457) 2633 598.9 1.1e-170
NP_870986 (OMIM: 102900,266200,609712) pyruvate ki ( 543) 2547 579.7 7.5e-165
NP_000289 (OMIM: 102900,266200,609712) pyruvate ki ( 574) 2547 579.7 7.9e-165
XP_006711449 (OMIM: 102900,266200,609712) PREDICTE ( 510) 2484 565.6 1.3e-160
XP_011507942 (OMIM: 102900,266200,609712) PREDICTE ( 510) 2484 565.6 1.3e-160
XP_016856982 (OMIM: 102900,266200,609712) PREDICTE ( 383) 1557 358.1 2.8e-98


>>NP_002645 (OMIM: 179050) pyruvate kinase PKM isoform a  (531 aa)
 initn: 3465 init1: 3465 opt: 3465  Z-score: 4190.8  bits: 785.1 E(85289):    0
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 531 aa overlap (1-531:1-531)

               10        20        30        40        50        60
pF1KB9 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
              430       440       450       460       470       480

              490       500       510       520       530 
pF1KB9 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
              490       500       510       520       530 

>>XP_005254502 (OMIM: 179050) PREDICTED: pyruvate kinase  (531 aa)
 initn: 3465 init1: 3465 opt: 3465  Z-score: 4190.8  bits: 785.1 E(85289):    0
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 531 aa overlap (1-531:1-531)

               10        20        30        40        50        60
pF1KB9 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
              430       440       450       460       470       480

              490       500       510       520       530 
pF1KB9 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
              490       500       510       520       530 

>>XP_011519972 (OMIM: 179050) PREDICTED: pyruvate kinase  (566 aa)
 initn: 3465 init1: 3465 opt: 3465  Z-score: 4190.4  bits: 785.1 E(85289):    0
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 531 aa overlap (1-531:36-566)

                                             10        20        30
pF1KB9                               MSKPHSEAGTAFIQTQQLHAAMADTFLEHM
                                     ::::::::::::::::::::::::::::::
XP_011 ERGERLLTPGACSSEVPSAVPSRSGGTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLEHM
          10        20        30        40        50        60     

               40        50        60        70        80        90
pF1KB9 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
          70        80        90       100       110       120     

              100       110       120       130       140       150
pF1KB9 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
         130       140       150       160       170       180     

              160       170       180       190       200       210
pF1KB9 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
         190       200       210       220       230       240     

              220       230       240       250       260       270
pF1KB9 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
         250       260       270       280       290       300     

              280       290       300       310       320       330
pF1KB9 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
         310       320       330       340       350       360     

              340       350       360       370       380       390
pF1KB9 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
         370       380       390       400       410       420     

              400       410       420       430       440       450
pF1KB9 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
         430       440       450       460       470       480     

              460       470       480       490       500       510
pF1KB9 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
         490       500       510       520       530       540     

              520       530 
pF1KB9 VLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::
XP_011 VLTGWRPGSGFTNTMRVVPVP
         550       560      

>>XP_005254500 (OMIM: 179050) PREDICTED: pyruvate kinase  (591 aa)
 initn: 3465 init1: 3465 opt: 3465  Z-score: 4190.2  bits: 785.2 E(85289):    0
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 531 aa overlap (1-531:61-591)

                                             10        20        30
pF1KB9                               MSKPHSEAGTAFIQTQQLHAAMADTFLEHM
                                     ::::::::::::::::::::::::::::::
XP_005 LVRPRSHPEPKGEHYVTGSPTPENQRTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLEHM
               40        50        60        70        80        90

               40        50        60        70        80        90
pF1KB9 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
              100       110       120       130       140       150

              100       110       120       130       140       150
pF1KB9 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
              160       170       180       190       200       210

              160       170       180       190       200       210
pF1KB9 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
              220       230       240       250       260       270

              220       230       240       250       260       270
pF1KB9 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
              280       290       300       310       320       330

              280       290       300       310       320       330
pF1KB9 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
              340       350       360       370       380       390

              340       350       360       370       380       390
pF1KB9 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
              400       410       420       430       440       450

              400       410       420       430       440       450
pF1KB9 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
              460       470       480       490       500       510

              460       470       480       490       500       510
pF1KB9 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
              520       530       540       550       560       570

              520       530 
pF1KB9 VLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::
XP_005 VLTGWRPGSGFTNTMRVVPVP
              580       590 

>>XP_006720633 (OMIM: 179050) PREDICTED: pyruvate kinase  (605 aa)
 initn: 3465 init1: 3465 opt: 3465  Z-score: 4190.0  bits: 785.2 E(85289):    0
Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 531 aa overlap (1-531:75-605)

                                             10        20        30
pF1KB9                               MSKPHSEAGTAFIQTQQLHAAMADTFLEHM
                                     ::::::::::::::::::::::::::::::
XP_006 LVRPRSHPEPKGEHYVTGSPTPENQRTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLEHM
           50        60        70        80        90       100    

               40        50        60        70        80        90
pF1KB9 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
          110       120       130       140       150       160    

              100       110       120       130       140       150
pF1KB9 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
          170       180       190       200       210       220    

              160       170       180       190       200       210
pF1KB9 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
          230       240       250       260       270       280    

              220       230       240       250       260       270
pF1KB9 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
          290       300       310       320       330       340    

              280       290       300       310       320       330
pF1KB9 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
          350       360       370       380       390       400    

              340       350       360       370       380       390
pF1KB9 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
          410       420       430       440       450       460    

              400       410       420       430       440       450
pF1KB9 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
          470       480       490       500       510       520    

              460       470       480       490       500       510
pF1KB9 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
          530       540       550       560       570       580    

              520       530 
pF1KB9 VLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::
XP_006 VLTGWRPGSGFTNTMRVVPVP
          590       600     

>>XP_016877802 (OMIM: 179050) PREDICTED: pyruvate kinase  (531 aa)
 initn: 3325 init1: 3325 opt: 3325  Z-score: 4021.5  bits: 753.8 E(85289): 2.9e-217
Smith-Waterman score: 3325; 95.9% identity (98.3% similar) in 531 aa overlap (1-531:1-531)

               10        20        30        40        50        60
pF1KB9 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
       ::::::::::::::::::::::::::::..: .::::: : .  ..:  :: :.:.::::
XP_016 LSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEAS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
       .:: ..:.::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
              430       440       450       460       470       480

              490       500       510       520       530 
pF1KB9 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
              490       500       510       520       530 

>>NP_872271 (OMIM: 179050) pyruvate kinase PKM isoform b  (531 aa)
 initn: 3325 init1: 3325 opt: 3325  Z-score: 4021.5  bits: 753.8 E(85289): 2.9e-217
Smith-Waterman score: 3325; 95.9% identity (98.3% similar) in 531 aa overlap (1-531:1-531)

               10        20        30        40        50        60
pF1KB9 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
       ::::::::::::::::::::::::::::..: .::::: : .  ..:  :: :.:.::::
NP_872 LSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEAS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
       .:: ..:.::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_872 YKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
              430       440       450       460       470       480

              490       500       510       520       530 
pF1KB9 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
              490       500       510       520       530 

>>NP_872270 (OMIM: 179050) pyruvate kinase PKM isoform b  (531 aa)
 initn: 3325 init1: 3325 opt: 3325  Z-score: 4021.5  bits: 753.8 E(85289): 2.9e-217
Smith-Waterman score: 3325; 95.9% identity (98.3% similar) in 531 aa overlap (1-531:1-531)

               10        20        30        40        50        60
pF1KB9 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
       ::::::::::::::::::::::::::::..: .::::: : .  ..:  :: :.:.::::
NP_872 LSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEAS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
       .:: ..:.::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_872 YKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
              430       440       450       460       470       480

              490       500       510       520       530 
pF1KB9 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
              490       500       510       520       530 

>>NP_001193728 (OMIM: 179050) pyruvate kinase PKM isofor  (536 aa)
 initn: 3325 init1: 3325 opt: 3325  Z-score: 4021.5  bits: 753.8 E(85289): 2.9e-217
Smith-Waterman score: 3325; 95.9% identity (98.3% similar) in 531 aa overlap (1-531:6-536)

                    10        20        30        40        50     
pF1KB9      MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPAS
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPAS
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KB9 RSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTK
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KB9 GPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIY
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KB9 VDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQ
              190       200       210       220       230       240

         240       250       260       270       280       290     
pF1KB9 DVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARG
              250       260       270       280       290       300

         300       310       320       330       340       350     
pF1KB9 DLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDG
              310       320       330       340       350       360

         360       370       380       390       400       410     
pF1KB9 ADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVG
       :::::::::::::::::::::::::::::::::..: .::::: : .  ..:  :: :.:
NP_001 ADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMG
              370       380       390       400       410       420

         420       430       440       450       460       470     
pF1KB9 AVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCK
       .::::.:: ..:.::::.::::::::::::::::::::::::::::::::::::::::::
NP_001 SVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCK
              430       440       450       460       470       480

         480       490       500       510       520       530 
pF1KB9 DPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
              490       500       510       520       530      

>>NP_001303247 (OMIM: 179050) pyruvate kinase PKM isofor  (566 aa)
 initn: 3325 init1: 3325 opt: 3325  Z-score: 4021.1  bits: 753.8 E(85289): 3.1e-217
Smith-Waterman score: 3325; 95.9% identity (98.3% similar) in 531 aa overlap (1-531:36-566)

                                             10        20        30
pF1KB9                               MSKPHSEAGTAFIQTQQLHAAMADTFLEHM
                                     ::::::::::::::::::::::::::::::
NP_001 ERGERLLTPGACSSEVPSAVPSRSGGTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLEHM
          10        20        30        40        50        60     

               40        50        60        70        80        90
pF1KB9 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKN
          70        80        90       100       110       120     

              100       110       120       130       140       150
pF1KB9 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYME
         130       140       150       160       170       180     

              160       170       180       190       200       210
pF1KB9 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVN
         190       200       210       220       230       240     

              220       230       240       250       260       270
pF1KB9 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISK
         250       260       270       280       290       300     

              280       290       300       310       320       330
pF1KB9 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQM
         310       320       330       340       350       360     

              340       350       360       370       380       390
pF1KB9 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::..
NP_001 LESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMF
         370       380       390       400       410       420     

              400       410       420       430       440       450
pF1KB9 HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
       : .::::: : .  ..:  :: :.:.::::.:: ..:.::::.:::::::::::::::::
NP_001 HRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPI
         430       440       450       460       470       480     

              460       470       480       490       500       510
pF1KB9 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVI
         490       500       510       520       530       540     

              520       530 
pF1KB9 VLTGWRPGSGFTNTMRVVPVP
       :::::::::::::::::::::
NP_001 VLTGWRPGSGFTNTMRVVPVP
         550       560      




531 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 14:58:06 2016 done: Sat Nov  5 14:58:08 2016
 Total Scan time:  9.240 Total Display time:  0.120

Function used was FASTA [36.3.4 Apr, 2011]
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