Result of FASTA (omim) for pF1KE0115
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0115, 228 aa
  1>>>pF1KE0115 228 - 228 aa - 228 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6906+/-0.00036; mu= 12.7359+/- 0.022
 mean_var=77.8623+/-16.105, 0's: 0 Z-trim(115.1): 62  B-trim: 1433 in 2/51
 Lambda= 0.145349
 statistics sampled from 25277 (25341) to 25277 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.297), width:  16
 Scan time:  6.600

The best scores are:                                      opt bits E(85289)
NP_113623 (OMIM: 612531) THAP domain-containing pr ( 228) 1515 326.8 1.9e-89
NP_612359 (OMIM: 612532) THAP domain-containing pr ( 175)  280 67.7 1.4e-11
XP_011540703 (OMIM: 612532) PREDICTED: THAP domain ( 148)  275 66.7 2.5e-11
NP_060575 (OMIM: 602629,609520) THAP domain-contai ( 213)  277 67.2 2.5e-11
XP_016858250 (OMIM: 612532) PREDICTED: THAP domain ( 168)  275 66.7 2.7e-11
NP_001182682 (OMIM: 612532) THAP domain-containing ( 239)  275 66.8 3.7e-11
XP_005263589 (OMIM: 612532) PREDICTED: THAP domain ( 238)  270 65.7 7.6e-11
NP_001182681 (OMIM: 612532) THAP domain-containing ( 238)  270 65.7 7.6e-11
NP_057047 (OMIM: 612533) THAP domain-containing pr ( 577)  247 61.1 4.5e-09
XP_005247073 (OMIM: 612533) PREDICTED: THAP domain ( 711)  247 61.2 5.3e-09
NP_001123947 (OMIM: 612534) THAP domain-containing ( 395)  230 57.5 3.9e-08
NP_001318031 (OMIM: 612536) THAP domain-containing ( 233)  225 56.3 5.2e-08
NP_689871 (OMIM: 612536) THAP domain-containing pr ( 274)  225 56.3 5.9e-08
NP_004696 (OMIM: 607374) 52 kDa repressor of the i ( 761)  229 57.4 7.7e-08
XP_011529968 (OMIM: 612535) PREDICTED: THAP domain ( 222)  220 55.2   1e-07
XP_011529969 (OMIM: 612535) PREDICTED: THAP domain ( 222)  220 55.2   1e-07
NP_653322 (OMIM: 612535) THAP domain-containing pr ( 222)  220 55.2   1e-07
XP_016859745 (OMIM: 612533) PREDICTED: THAP domain ( 601)  197 50.7 6.6e-06
XP_011509593 (OMIM: 612533) PREDICTED: THAP domain ( 628)  197 50.7 6.9e-06
NP_078948 (OMIM: 612537) DNA transposase THAP9 iso ( 903)  199 51.2 6.9e-06
XP_005262831 (OMIM: 612535) PREDICTED: THAP domain ( 160)  185 47.8 1.3e-05
NP_085050 (OMIM: 609518) THAP domain-containing pr ( 309)  179 46.7 5.2e-05
NP_001008695 (OMIM: 609518) THAP domain-containing ( 309)  179 46.7 5.2e-05
XP_016863290 (OMIM: 612535) PREDICTED: THAP domain ( 147)  169 44.4 0.00012
XP_006714172 (OMIM: 612535) PREDICTED: THAP domain ( 172)  169 44.5 0.00014
NP_001304720 (OMIM: 612535) THAP domain-containing ( 180)  169 44.5 0.00014
XP_016863289 (OMIM: 612535) PREDICTED: THAP domain ( 180)  169 44.5 0.00014
XP_005262829 (OMIM: 612535) PREDICTED: THAP domain ( 181)  169 44.5 0.00014
XP_016864092 (OMIM: 612537) PREDICTED: DNA transpo ( 916)  178 46.8 0.00015
NP_064532 (OMIM: 612538) THAP domain-containing pr ( 257)  153 41.2   0.002
NP_001318032 (OMIM: 612536) THAP domain-containing ( 231)  148 40.1  0.0037
NP_001318033 (OMIM: 612536) THAP domain-containing ( 231)  148 40.1  0.0037


>>NP_113623 (OMIM: 612531) THAP domain-containing protei  (228 aa)
 initn: 1515 init1: 1515 opt: 1515  Z-score: 1726.9  bits: 326.8 E(85289): 1.9e-89
Smith-Waterman score: 1515; 100.0% identity (100.0% similar) in 228 aa overlap (1-228:1-228)

               10        20        30        40        50        60
pF1KE0 MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEAS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 CFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 LLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 LLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANS
              130       140       150       160       170       180

              190       200       210       220        
pF1KE0 VLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTKSTFI
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_113 VLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTKSTFI
              190       200       210       220        

>>NP_612359 (OMIM: 612532) THAP domain-containing protei  (175 aa)
 initn: 257 init1: 185 opt: 280  Z-score: 329.0  bits: 67.7 E(85289): 1.4e-11
Smith-Waterman score: 280; 34.6% identity (63.9% similar) in 133 aa overlap (1-131:1-130)

               10         20         30        40        50        
pF1KE0 MPTNCAAAGCATTYN-KHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFE
       :: .:::  : . :. .. ...:::::.. :.  ::::  . : :: : .:: .::.::.
NP_612 MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFR
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE0 ASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQ
         ::.  :. . :: .::::.: :    .... ..    ...:. :    .. :..   .
NP_612 PECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSS---QKEKTSPCRS
               70        80        90       100          110       

      120       130       140       150       160       170        
pF1KE0 QVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEA
       ::: : . .  .:                                               
NP_612 QVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQAMLFNVENGTPASREALWLSEE  
       120       130       140       150       160       170       

>>XP_011540703 (OMIM: 612532) PREDICTED: THAP domain-con  (148 aa)
 initn: 257 init1: 185 opt: 275  Z-score: 324.5  bits: 66.7 E(85289): 2.5e-11
Smith-Waterman score: 275; 37.7% identity (67.0% similar) in 106 aa overlap (1-104:1-106)

               10         20         30        40        50        
pF1KE0 MPTNCAAAGCATTYN-KHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFE
       :: .:::  : . :. .. ...:::::.. :.  ::::  . : :: : .:: .::.::.
XP_011 MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFR
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE0 ASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQ
         ::.  :. . :: .::::.: :    .... ..    ...:. :              
XP_011 PECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKVLPEAGAGE
               70        80        90       100       110       120

      120       130       140       150       160       170        
pF1KE0 QVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEA
                                                                   
XP_011 DSPGRNMDTALEELQLPPNAEGHVKQIP                                
              130       140                                        

>>NP_060575 (OMIM: 602629,609520) THAP domain-containing  (213 aa)
 initn: 339 init1: 171 opt: 277  Z-score: 324.4  bits: 67.2 E(85289): 2.5e-11
Smith-Waterman score: 366; 35.3% identity (63.2% similar) in 201 aa overlap (1-185:1-197)

               10        20         30        40        50         
pF1KE0 MPTNCAAAGCATTYNKHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFEA
       :  .:.: :: . :.:   .:::.:::  :.  :::   :::::: : :.. .::.::  
NP_060 MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTP
               10        20        30        40        50        60

      60        70        80        90       100           110     
pF1KE0 SCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAG-P---SNLKSNI
       .::    ... :: .:::::: .::. ..   :...::. ...  :   :   :.. . :
NP_060 DCFKRECNNKLLKENAVPTIF-LCTEPHD---KKEDLLEPQEQLPPPPLPPPVSQVDAAI
               70        80            90       100       110      

                   120       130       140       150       160     
pF1KE0 S----------SQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRR
       .          . .:. .:.:. .. :. .::: .::... .::.:.::  :. ::  :.
NP_060 GLLMPPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQ
        120       130       140       150       160       170      

         170        180       190       200       210       220    
pF1KE0 WIKATCLVK-NLEANSVLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTK
         :   .:. . : ..:  .:                                       
NP_060 LEKLKEVVHFQKEKDDVSERGYVILPNDYFEIVEVPA                       
        180       190       200       210                          

>>XP_016858250 (OMIM: 612532) PREDICTED: THAP domain-con  (168 aa)
 initn: 257 init1: 185 opt: 275  Z-score: 323.6  bits: 66.7 E(85289): 2.7e-11
Smith-Waterman score: 275; 37.7% identity (67.0% similar) in 106 aa overlap (1-104:1-106)

               10         20         30        40        50        
pF1KE0 MPTNCAAAGCATTYN-KHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFE
       :: .:::  : . :. .. ...:::::.. :.  ::::  . : :: : .:: .::.::.
XP_016 MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFR
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE0 ASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQ
         ::.  :. . :: .::::.: :    .... ..    ...:. :              
XP_016 PECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKVLPEAGAGE
               70        80        90       100       110       120

      120       130       140       150       160       170        
pF1KE0 QVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEA
                                                                   
XP_016 DSPGRNMDTALEELQLPPNAEGHVKQAMLFNVENGTPASREALWLSEE            
              130       140       150       160                    

>>NP_001182682 (OMIM: 612532) THAP domain-containing pro  (239 aa)
 initn: 309 init1: 185 opt: 275  Z-score: 321.4  bits: 66.8 E(85289): 3.7e-11
Smith-Waterman score: 275; 37.7% identity (67.0% similar) in 106 aa overlap (1-104:1-106)

               10         20         30        40        50        
pF1KE0 MPTNCAAAGCATTYN-KHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFE
       :: .:::  : . :. .. ...:::::.. :.  ::::  . : :: : .:: .::.::.
NP_001 MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFR
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE0 ASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQ
         ::.  :. . :: .::::.: :    .... ..    ...:. :              
NP_001 PECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKVLPEAGAGE
               70        80        90       100       110       120

      120       130       140       150       160       170        
pF1KE0 QVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEA
                                                                   
NP_001 DSPGRNMDTALEELQLPPNAEGHVKQVSPRRPQATEAVGRPTGPAGLRRTPNKQPSDHSY
              130       140       150       160       170       180

>>XP_005263589 (OMIM: 612532) PREDICTED: THAP domain-con  (238 aa)
 initn: 309 init1: 185 opt: 270  Z-score: 315.7  bits: 65.7 E(85289): 7.6e-11
Smith-Waterman score: 270; 45.2% identity (70.2% similar) in 84 aa overlap (1-82:1-84)

               10         20         30        40        50        
pF1KE0 MPTNCAAAGCATTYN-KHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFE
       :: .:::  : . :. .. ...:::::.. :.  ::::  . : :: : .:: .::.::.
XP_005 MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFR
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE0 ASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQ
         ::.  :. . :: .::::.: :                                    
XP_005 PECFSAFGNRKNLKHNAVPTVFAFQDPTQVRENTDPASERGNASSSQKEKVLPEAGAGED
               70        80        90       100       110       120

>>NP_001182681 (OMIM: 612532) THAP domain-containing pro  (238 aa)
 initn: 309 init1: 185 opt: 270  Z-score: 315.7  bits: 65.7 E(85289): 7.6e-11
Smith-Waterman score: 270; 45.2% identity (70.2% similar) in 84 aa overlap (1-82:1-84)

               10         20         30        40        50        
pF1KE0 MPTNCAAAGCATTYN-KHINISFHRFPLD-PKRRKEWVRLVRRKNFVPGKHTFLCSKHFE
       :: .:::  : . :. .. ...:::::.. :.  ::::  . : :: : .:: .::.::.
NP_001 MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFR
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KE0 ASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQ
         ::.  :. . :: .::::.: :                                    
NP_001 PECFSAFGNRKNLKHNAVPTVFAFQDPTQVRENTDPASERGNASSSQKEKVLPEAGAGED
               70        80        90       100       110       120

>>NP_057047 (OMIM: 612533) THAP domain-containing protei  (577 aa)
 initn: 186 init1: 126 opt: 247  Z-score: 283.9  bits: 61.1 E(85289): 4.5e-09
Smith-Waterman score: 247; 34.5% identity (61.5% similar) in 148 aa overlap (1-143:1-146)

               10          20         30        40        50       
pF1KE0 MPTNCAAAGCATTYNK--HINISFHRFPL-DPKRRKEWVRLVRRKNFVPGKHTFLCSKHF
       :   :::..:..  .:  .  .::::::: : ::  .:.. :.: :..: :..::::.::
NP_057 MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHF
               10        20        30        40        50        60

        60          70        80        90       100       110     
pF1KE0 EASCFD--LTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNI
         . :.  :  : : ::  :::.:: .  . ..   ..:.  .:. : . .:  . .:  
NP_057 TKDSFSKRLEDQHRLLKPTAVPSIFHLTEKKRGAGGHGRTR-RKDASKATGGVRGHSSAA
               70        80        90       100        110         

         120       130       140       150       160       170     
pF1KE0 SSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKN
       .:. .      .  ::: :: .  .:..                                
NP_057 TSRGAAGWSPSSSGNPM-AKPESRRLKQAALQGEATPRAAQEAASQEQAQQALERTPGDG
     120       130        140       150       160       170        

>>XP_005247073 (OMIM: 612533) PREDICTED: THAP domain-con  (711 aa)
 initn: 166 init1: 126 opt: 247  Z-score: 282.6  bits: 61.2 E(85289): 5.3e-09
Smith-Waterman score: 247; 34.5% identity (61.5% similar) in 148 aa overlap (1-143:108-253)

                                             10          20        
pF1KE0                               MPTNCAAAGCATTYNK--HINISFHRFPL-
                                     :   :::..:..  .:  .  .::::::: 
XP_005 SPPRSLPRGGPRAGGRLGPGPGCAAGPRPAMVICCAAVNCSNRQGKGEKRAVSFHRFPLK
        80        90       100       110       120       130       

        30        40        50        60          70        80     
pF1KE0 DPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFD--LTGQTRRLKMDAVPTIFDFCTH
       : ::  .:.. :.: :..: :..::::.::  . :.  :  : : ::  :::.:: .  .
XP_005 DSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLTEK
       140       150       160       170       180       190       

          90       100       110       120       130       140     
pF1KE0 IKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQVLLEHSYAFRNPMEAKKRIIKLEKEI
        ..   ..:.  .:. : . .:  . .:  .:. .      .  ::: :: .  .:..  
XP_005 KRGAGGHGRTR-RKDASKATGGVRGHSSAATSRGAAGWSPSSSGNPM-AKPESRRLKQAA
       200        210       220       230       240        250     

         150       160       170       180       190       200     
pF1KE0 ASLRRKMKTCLQKERRATRRWIKATCLVKNLEANSVLPKGTSEHMLPTALSSLPLEDFKI
                                                                   
XP_005 LQGEATPRAAQEAASQEQAQQALERTPGDGLATMVAGSQGKAEASATDAGDESATSSIEG
         260       270       280       290       300       310     




228 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 02:28:17 2016 done: Fri Nov  4 02:28:18 2016
 Total Scan time:  6.600 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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