Result of FASTA (omim) for pF1KB6588
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6588, 406 aa
  1>>>pF1KB6588 406 - 406 aa - 406 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.6052+/-0.000391; mu= 10.7122+/- 0.024
 mean_var=101.2428+/-20.518, 0's: 0 Z-trim(114.3): 183  B-trim: 336 in 2/53
 Lambda= 0.127465
 statistics sampled from 23814 (24005) to 23814 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.281), width:  16
 Scan time:  8.550

The best scores are:                                      opt bits E(85289)
NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 2613 491.2 1.9e-138
NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 2557 480.9 2.3e-135
NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 1168 225.5 1.9e-58
NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 1161 224.2 4.8e-58
XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 1156 223.3 7.7e-58
NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 1156 223.3 7.7e-58
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 1141 220.5 5.7e-57
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 1055 204.8 3.5e-52
NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 1052 204.2 4.9e-52
NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 1051 204.0 5.3e-52
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 1008 196.0 9.8e-50
XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461)  995 193.7 7.7e-49
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730)  713 142.0 4.6e-33
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797)  713 142.0   5e-33
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806)  689 137.6 1.1e-31
NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795)  634 127.5 1.2e-28
XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809)  634 127.5 1.2e-28
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695)  631 126.9 1.5e-28
XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790)  631 126.9 1.7e-28
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819)  631 126.9 1.8e-28
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892)  631 126.9 1.9e-28
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893)  631 126.9 1.9e-28
XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561)  626 125.9 2.4e-28
XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618)  626 125.9 2.6e-28
NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892)  627 126.2 3.1e-28
XP_011512963 (OMIM: 601498,614862,614863,616617) P ( 952)  627 126.2 3.3e-28
NP_000278 (OMIM: 601498,614862,614863,616617) pero ( 980)  627 126.2 3.4e-28
NP_001240795 (OMIM: 607472) ATP-dependent zinc met ( 683)  619 124.7   7e-28
NP_055078 (OMIM: 607472) ATP-dependent zinc metall ( 716)  619 124.7 7.2e-28
XP_011517602 (OMIM: 607472) PREDICTED: ATP-depende ( 740)  619 124.7 7.4e-28
NP_647473 (OMIM: 607472) ATP-dependent zinc metall ( 773)  619 124.7 7.7e-28
XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593)  607 122.4 2.9e-27
XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953)  610 123.1 2.9e-27
XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260)  610 123.2 3.7e-27
NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390)  610 123.2   4e-27
XP_016863318 (OMIM: 613940,616577) PREDICTED: sper ( 765)  603 121.8 5.9e-27
XP_016863316 (OMIM: 613940,616577) PREDICTED: sper ( 823)  603 121.8 6.3e-27
XP_016863315 (OMIM: 613940,616577) PREDICTED: sper ( 859)  603 121.8 6.5e-27
XP_011529980 (OMIM: 613940,616577) PREDICTED: sper ( 916)  603 121.8 6.9e-27
XP_016863314 (OMIM: 613940,616577) PREDICTED: sper ( 917)  603 121.8 6.9e-27
XP_016867808 (OMIM: 214100,234580,601539,602136) P ( 700)  597 120.6 1.2e-26
NP_001269607 (OMIM: 214100,234580,601539,602136) p (1075)  597 120.7 1.7e-26
NP_001269606 (OMIM: 214100,234580,601539,602136) p (1226)  597 120.8 1.9e-26
NP_000457 (OMIM: 214100,234580,601539,602136) pero (1283)  597 120.8   2e-26
XP_011531234 (OMIM: 615347) PREDICTED: ATPase fami ( 791)  581 117.7   1e-25
XP_011531233 (OMIM: 615347) PREDICTED: ATPase fami ( 837)  581 117.7   1e-25
XP_011531232 (OMIM: 615347) PREDICTED: ATPase fami ( 841)  581 117.7 1.1e-25
XP_011531231 (OMIM: 615347) PREDICTED: ATPase fami ( 843)  581 117.7 1.1e-25
XP_011531230 (OMIM: 615347) PREDICTED: ATPase fami ( 849)  581 117.7 1.1e-25
XP_006712094 (OMIM: 615347) PREDICTED: ATPase fami (1067)  581 117.8 1.3e-25


>>NP_002796 (OMIM: 601681) 26S protease regulatory subun  (406 aa)
 initn: 2613 init1: 2613 opt: 2613  Z-score: 2606.7  bits: 491.2 E(85289): 1.9e-138
Smith-Waterman score: 2613; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406)

               10        20        30        40        50        60
pF1KB6 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
              310       320       330       340       350       360

              370       380       390       400      
pF1KB6 GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
              370       380       390       400      

>>NP_001186092 (OMIM: 601681) 26S protease regulatory su  (398 aa)
 initn: 2557 init1: 2557 opt: 2557  Z-score: 2551.2  bits: 480.9 E(85289): 2.3e-135
Smith-Waterman score: 2557; 100.0% identity (100.0% similar) in 398 aa overlap (9-406:1-398)

               10        20        30        40        50        60
pF1KB6 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
               ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001         MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
                       10        20        30        40        50  

               70        80        90       100       110       120
pF1KB6 EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
             60        70        80        90       100       110  

              130       140       150       160       170       180
pF1KB6 YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
            120       130       140       150       160       170  

              190       200       210       220       230       240
pF1KB6 AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
            180       190       200       210       220       230  

              250       260       270       280       290       300
pF1KB6 HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
            240       250       260       270       280       290  

              310       320       330       340       350       360
pF1KB6 LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
            300       310       320       330       340       350  

              370       380       390       400      
pF1KB6 GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
            360       370       380       390        

>>NP_002794 (OMIM: 154365) 26S protease regulatory subun  (433 aa)
 initn: 1149 init1: 1149 opt: 1168  Z-score: 1170.2  bits: 225.5 E(85289): 1.9e-58
Smith-Waterman score: 1168; 50.8% identity (73.9% similar) in 372 aa overlap (22-392:53-418)

                        10        20        30        40        50 
pF1KB6          MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNE
                                     :  :.::.::  :   : ..         .
NP_002 RALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGI---KESDTGLAPPALWD
             30        40        50        60           70         

              60        70         80        90       100       110
pF1KB6 LNAKVRLLREELQLLQEQGSYVGEVVRA-MDKKKVLVKVHPEGKFVVDVDKNIDINDVTP
       : :  . :. :  :   : .   ... :  .  : ...:.  .:::::.. ..  .:.  
NP_002 LAADKQTLQSEQPL---QVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEE
      80        90          100       110       120       130      

              120       130       140       150       160       170
pF1KB6 NCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVK
       . ::..  ..: .:  :: :.:: :..:.::. :: ::  .::  .::....::.: :. 
NP_002 GMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLL
        140       150       160       170       180       190      

              180       190       200       210       220       230
pF1KB6 HPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARM
       ::: :  :::  ::::::.::::::::: :::::..::  :::: :::::::..::::::
NP_002 HPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARM
        200       210       220       230       240       250      

              240       250       260       270       280       290
pF1KB6 VRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIK
       ::::: ::: .   .::.::::.::..:.. :.:::.:::::::::.::::::.   :::
NP_002 VRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIK
        260       270       280       290       300       310      

              300       310       320       330       340       350
pF1KB6 VIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAEL
       :.::::: : :: ::.::::.::::::  :. :.:  :.:::.:.:.. : : .. .:.:
NP_002 VLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARL
        320       330       340       350       360       370      

              360       370       380       390       400       
pF1KB6 MPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 
        :...:::...:::::::.:.: ::  .:..::  :: ::..               
NP_002 CPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
        380       390       400       410       420       430   

>>NP_002793 (OMIM: 602706) 26S protease regulatory subun  (440 aa)
 initn: 1096 init1: 1073 opt: 1161  Z-score: 1163.1  bits: 224.2 E(85289): 4.8e-58
Smith-Waterman score: 1161; 46.3% identity (74.8% similar) in 393 aa overlap (4-396:44-432)

                                          10        20        30   
pF1KB6                            MALDGPEQMELEEGKAGSGLRQYYLSKIEELQL
                                     :.  .. :   ..   :.   : .:..  :
NP_002 GKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLL
            20        30        40        50        60        70   

            40        50        60        70        80        90   
pF1KB6 IVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEG
       .     ... : : : . :. : .  : ... :.     :: . . .: ....:..   .
NP_002 M----EEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGS
                80        90       100       110       120         

           100       110       120       130       140       150   
pF1KB6 KFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGG
       .  :.. . .: . . :.: : : .  ...  .: . .::::..: :::.:. ::  :::
NP_002 EHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGG
     130       140       150       160       170       180         

           160       170       180       190       200       210   
pF1KB6 LDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIR
       ::.::.:::: .:::. ::: .: .::  ::::.:::::::::::::.:::..:. ::.:
NP_002 LDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLR
     190       200       210       220       230       240         

           220       230       240       250       260       270   
pF1KB6 VSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTM
       : ::::.::..:.: ..::::: .:.::::::.:.::::.::..: ...:::. :.::::
NP_002 VVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTM
     250       260       270       280       290       300         

           280       290       300       310       320       330   
pF1KB6 LELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHS
       ::::::::::..  ..:::::::::. :: ::.:::::::::::: :.:...  :..::.
NP_002 LELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHT
     310       320       330       340       350       360         

           340       350       360       370       380       390   
pF1KB6 RKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQK
        .:.:.  ..:  .       :::..:..:::::..::::::..::.:::. .  .:. :
NP_002 SRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYK
     370       380       390       400       410       420         

           400      
pF1KB6 DSEKNMSIKKLWK
        .:          
NP_002 KQEGTPEGLYL  
     430       440  

>>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re  (367 aa)
 initn: 1096 init1: 1073 opt: 1156  Z-score: 1159.4  bits: 223.3 E(85289): 7.7e-58
Smith-Waterman score: 1156; 49.9% identity (77.9% similar) in 353 aa overlap (44-396:7-359)

            20        30        40        50        60        70   
pF1KB6 GKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYV
                                     : : : . :. : .  : ... :.     :
XP_016                         MEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSV
                                       10        20        30      

            80        90       100       110       120       130   
pF1KB6 GEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDP
       : . . .: ....:..   ..  :.. . .: . . :.: : : .  ...  .: . .::
XP_016 GTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDP
         40        50        60        70        80        90      

           140       150       160       170       180       190   
pF1KB6 LVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPG
       ::..: :::.:. ::  :::::.::.:::: .:::. ::: .: .::  ::::.::::::
XP_016 LVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPG
        100       110       120       130       140       150      

           200       210       220       230       240       250   
pF1KB6 TGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDS
       :::::::.:::..:. ::.:: ::::.::..:.: ..::::: .:.::::::.:.::::.
XP_016 TGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDA
        160       170       180       190       200       210      

           260       270       280       290       300       310   
pF1KB6 IGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDR
       ::..: ...:::. :.::::::::::::::..  ..:::::::::. :: ::.:::::::
XP_016 IGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDR
        220       230       240       250       260       270      

           320       330       340       350       360       370   
pF1KB6 KIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE
       ::::: :.:...  :..::. .:.:.  ..:  .       :::..:..:::::..::::
XP_016 KIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE
        280       290       300       310       320       330      

           380       390       400      
pF1KB6 RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
       ::..::.:::. .  .:. : .:          
XP_016 RRMKVTNEDFKKSKENVLYKKQEGTPEGLYL  
        340       350       360         

>>NP_001317141 (OMIM: 602706) 26S protease regulatory su  (367 aa)
 initn: 1096 init1: 1073 opt: 1156  Z-score: 1159.4  bits: 223.3 E(85289): 7.7e-58
Smith-Waterman score: 1156; 49.9% identity (77.9% similar) in 353 aa overlap (44-396:7-359)

            20        30        40        50        60        70   
pF1KB6 GKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYV
                                     : : : . :. : .  : ... :.     :
NP_001                         MEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSV
                                       10        20        30      

            80        90       100       110       120       130   
pF1KB6 GEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDP
       : . . .: ....:..   ..  :.. . .: . . :.: : : .  ...  .: . .::
NP_001 GTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDP
         40        50        60        70        80        90      

           140       150       160       170       180       190   
pF1KB6 LVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPG
       ::..: :::.:. ::  :::::.::.:::: .:::. ::: .: .::  ::::.::::::
NP_001 LVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPG
        100       110       120       130       140       150      

           200       210       220       230       240       250   
pF1KB6 TGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDS
       :::::::.:::..:. ::.:: ::::.::..:.: ..::::: .:.::::::.:.::::.
NP_001 TGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDA
        160       170       180       190       200       210      

           260       270       280       290       300       310   
pF1KB6 IGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDR
       ::..: ...:::. :.::::::::::::::..  ..:::::::::. :: ::.:::::::
NP_001 IGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDR
        220       230       240       250       260       270      

           320       330       340       350       360       370   
pF1KB6 KIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE
       ::::: :.:...  :..::. .:.:.  ..:  .       :::..:..:::::..::::
NP_001 KIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE
        280       290       300       310       320       330      

           380       390       400      
pF1KB6 RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
       ::..::.:::. .  .:. : .:          
NP_001 RRMKVTNEDFKKSKENVLYKKQEGTPEGLYL  
        340       350       360         

>>NP_002797 (OMIM: 602708) 26S protease regulatory subun  (403 aa)
 initn: 1136 init1: 1136 opt: 1141  Z-score: 1143.8  bits: 220.5 E(85289): 5.7e-57
Smith-Waterman score: 1141; 50.3% identity (76.1% similar) in 356 aa overlap (42-397:40-393)

              20        30        40        50        60        70 
pF1KB6 EEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGS
                                     :..:. : .::. . .  ...:. ::  :.
NP_002 RRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQ
      10        20        30        40        50        60         

              80        90       100       110       120       130 
pF1KB6 YVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKV
        ::::.. . ..: .::.    ..::   ...: . . :. ::::   . :. . :: .:
NP_002 IVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREV
      70        80        90       100       110       120         

             140       150       160       170       180       190 
pF1KB6 DPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGP
       ::::  :  :   . .:  ::::..::.:..::::::. .::::. .::  ::: :::::
NP_002 DPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGP
     130       140       150       160       170       180         

             200       210       220       230       240       250 
pF1KB6 PGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEI
       ::::::::::::: . ::.:..: .: .:.:.:::.::..::.: .::.: : :::::::
NP_002 PGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEI
     190       200       210       220       230       240         

             260       270       280       290       300       310 
pF1KB6 DSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRI
       :.::. :.  :...: :.:::..:::::.:::.. . .:.:::::: : :: :::::::.
NP_002 DAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRL
     250       260       270       280       290       300         

             320       330       340       350       360       370 
pF1KB6 DRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYAL
       ::::..  :::.:::::::::.  ..    :. . :..:  : .::....:::::::.:.
NP_002 DRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAI
     310       320       330       340       350       360         

             380       390       400       
pF1KB6 RERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 
       :  .  :.::::  :: ::   ::.:          
NP_002 RADHDFVVQEDFMKAVRKVA--DSKKLESKLDYKPV
     370       380         390       400   

>>NP_002795 (OMIM: 186852) 26S protease regulatory subun  (439 aa)
 initn: 1041 init1: 1019 opt: 1055  Z-score: 1057.8  bits: 204.8 E(85289): 3.5e-52
Smith-Waterman score: 1055; 45.1% identity (73.7% similar) in 377 aa overlap (20-393:55-430)

                          10        20        30        40         
pF1KB6            MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQR
                                     ...  :   .::: . .  ..: .......
NP_002 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK
           30        40        50        60        70        80    

      50           60        70        80        90       100      
pF1KB6 NE---LNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDIN
       .    ..  ..::  . .  .:.:. . ..      : ...:.  .  . . :   .: .
NP_002 TLPYLVSNVIELLDVDPNDQEEDGANI-DLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAE
           90       100       110        120       130       140   

        110       120       130       140       150       160      
pF1KB6 DVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIE
        . :.  :.. .::: . . ::.. :  :. : :.. :   :  ::::::::.:. :.: 
NP_002 KLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIV
           150       160       170       180       190       200   

        170       180       190       200       210       220      
pF1KB6 LPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGE
       ::..: : :: :::  :::::.:::::::::::::: : .:  ::....: .::: :::.
NP_002 LPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGD
           210       220       230       240       250       260   

        230       240       250       260       270       280      
pF1KB6 GARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEAT
       ::..::. :..:.:.::::::.::.:.::..:... ..:: ::::::::::::::::. .
NP_002 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN
           270       280       290       300       310       320   

        290       300       310       320       330       340      
pF1KB6 KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRK
        ..::: ::::.:::: :::: ::.::::::: ::::::  :..:::::::..  .: ..
NP_002 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEE
           330       340       350       360       370       380   

        350       360       370       380       390       400      
pF1KB6 IAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
       .:.     .::. :.::.:::: :::.  ...:.::.  .. .:. :             
NP_002 LARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA    
           390       400       410       420       430             

>>NP_006494 (OMIM: 602707) 26S protease regulatory subun  (418 aa)
 initn: 1045 init1: 1003 opt: 1052  Z-score: 1055.1  bits: 204.2 E(85289): 4.9e-52
Smith-Waterman score: 1073; 42.5% identity (71.4% similar) in 398 aa overlap (1-398:27-414)

                                         10        20        30    
pF1KB6                           MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLI
                                 ... :::  .::.  .     :  :  .:  .  
NP_006 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
               10        20        30        40        50        60

           40        50        60        70        80        90    
pF1KB6 VNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGK
       ..:...::..     . :.:.     ::.. .:     .:. ..:.:.. ..:     ..
NP_006 IKDEQKNLKK-----EFLHAQ-----EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSN
               70                  80        90       100       110

          100       110       120       130       140       150    
pF1KB6 FVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGL
       . : . ..:: . . ::  :::.. : .:  .:: ..:  . ..  .. ::  :  :::.
NP_006 YYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGM
              120       130       140       150       160       170

          160       170       180       190       200       210    
pF1KB6 DKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRV
       : : .:..:..:::. : ::.. .::  :.:::.::::: :::.::.::::::  .::::
NP_006 DIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRV
              180       190       200       210       220       230

          220       230       240       250       260       270    
pF1KB6 SGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTML
        :::.:::..::: ::::..: .:.:.::.:::.::::.:...:... .:.: :::: .:
NP_006 VGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILL
              240       250       260       270       280       290

          280       290       300       310       320       330    
pF1KB6 ELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSR
       :::::.:::. . :.:::::::: : :: :::::::.::::::: :... .  :..  . 
NP_006 ELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITS
              300       310       320       330       340       350

          340       350       360       370       380       390    
pF1KB6 KMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKD
       ::::.. ..:.  .      :::.....: :.:: :.:: :  :  .::: :   :..::
NP_006 KMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKD
              360       370       380       390       400       410

          400      
pF1KB6 SEKNMSIKKLWK
        ...        
NP_006 EQEHEFYK    
                   

>>NP_694546 (OMIM: 602707) 26S protease regulatory subun  (387 aa)
 initn: 1026 init1: 1003 opt: 1051  Z-score: 1054.7  bits: 204.0 E(85289): 5.3e-52
Smith-Waterman score: 1051; 44.0% identity (72.7% similar) in 366 aa overlap (33-398:18-383)

             10        20        30        40        50        60  
pF1KB6 LDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREE
                                     : :.  . .:  :  . ..:.      .::
NP_694              MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKEE
                            10        20        30        40       

             70        80        90       100       110       120  
pF1KB6 LQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYT
       .. .:     .:. ..:.:.. ..:     ... : . ..:: . . ::  :::.. : .
NP_694 VKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNA
        50        60        70        80        90       100       

            130       140       150       160       170       180  
pF1KB6 LHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQ
       :  .:: ..:  . ..  .. ::  :  :::.: : .:..:..:::. : ::.. .::  
NP_694 LVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDP
       110       120       130       140       150       160       

            190       200       210       220       230       240  
pF1KB6 PKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHA
       :.:::.::::: :::.::.::::::  .:::: :::.:::..::: ::::..: .:.:.:
NP_694 PRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENA
       170       180       190       200       210       220       

            250       260       270       280       290       300  
pF1KB6 PSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILD
       :.:::.::::.:...:... .:.: :::: .::::::.:::. . :.:::::::: : ::
NP_694 PAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLD
       230       240       250       260       270       280       

            310       320       330       340       350       360  
pF1KB6 SALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGV
        :::::::.::::::: :... .  :..  . ::::.. ..:.  .      :::.....
NP_694 PALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSI
       290       300       310       320       330       340       

            370       380       390       400      
pF1KB6 CTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
       : :.:: :.:: :  :  .::: :   :..:: ...        
NP_694 CQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK    
       350       360       370       380           




406 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 23:23:41 2016 done: Fri Nov  4 23:23:42 2016
 Total Scan time:  8.550 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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