FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6419, 309 aa 1>>>pF1KB6419 309 - 309 aa - 309 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7037+/-0.000413; mu= 0.9885+/- 0.026 mean_var=234.7155+/-48.171, 0's: 0 Z-trim(119.0): 11 B-trim: 44 in 1/55 Lambda= 0.083715 statistics sampled from 32491 (32502) to 32491 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.381), width: 16 Scan time: 7.350 The best scores are: opt bits E(85289) NP_002422 (OMIM: 602659) CDK-activating kinase ass ( 309) 2058 261.2 1.9e-69 XP_005267744 (OMIM: 602659) PREDICTED: CDK-activat ( 309) 2058 261.2 1.9e-69 XP_016876821 (OMIM: 602659) PREDICTED: CDK-activat ( 294) 1837 234.5 2e-61 XP_005267745 (OMIM: 602659) PREDICTED: CDK-activat ( 278) 1788 228.5 1.2e-59 NP_001171434 (OMIM: 602659) CDK-activating kinase ( 267) 1244 162.8 6.9e-40 XP_016876823 (OMIM: 602659) PREDICTED: CDK-activat ( 188) 1225 160.4 2.6e-39 XP_016876822 (OMIM: 602659) PREDICTED: CDK-activat ( 188) 1225 160.4 2.6e-39 >>NP_002422 (OMIM: 602659) CDK-activating kinase assembl (309 aa) initn: 2058 init1: 2058 opt: 2058 Z-score: 1367.6 bits: 261.2 E(85289): 1.9e-69 Smith-Waterman score: 2058; 100.0% identity (100.0% similar) in 309 aa overlap (1-309:1-309) 10 20 30 40 50 60 pF1KB6 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA 250 260 270 280 290 300 pF1KB6 FSGLFWQPS ::::::::: NP_002 FSGLFWQPS >>XP_005267744 (OMIM: 602659) PREDICTED: CDK-activating (309 aa) initn: 2058 init1: 2058 opt: 2058 Z-score: 1367.6 bits: 261.2 E(85289): 1.9e-69 Smith-Waterman score: 2058; 100.0% identity (100.0% similar) in 309 aa overlap (1-309:1-309) 10 20 30 40 50 60 pF1KB6 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA 250 260 270 280 290 300 pF1KB6 FSGLFWQPS ::::::::: XP_005 FSGLFWQPS >>XP_016876821 (OMIM: 602659) PREDICTED: CDK-activating (294 aa) initn: 1837 init1: 1837 opt: 1837 Z-score: 1223.6 bits: 234.5 E(85289): 2e-61 Smith-Waterman score: 1837; 100.0% identity (100.0% similar) in 279 aa overlap (31-309:16-294) 10 20 30 40 50 60 pF1KB6 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV :::::::::::::::::::::::::::::: XP_016 MQIRSCSVAQTGVHCCESCVDLLFVRGAGNCPECGTPLRKSNFRV 10 20 30 40 70 80 90 100 110 120 pF1KB6 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA 230 240 250 260 270 280 pF1KB6 FSGLFWQPS ::::::::: XP_016 FSGLFWQPS 290 >>XP_005267745 (OMIM: 602659) PREDICTED: CDK-activating (278 aa) initn: 1815 init1: 1788 opt: 1788 Z-score: 1192.0 bits: 228.5 E(85289): 1.2e-59 Smith-Waterman score: 1788; 98.2% identity (99.3% similar) in 275 aa overlap (1-275:1-275) 10 20 30 40 50 60 pF1KB6 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA :::::::::::::::::::::::::::::: .. . XP_005 LEEALYEYQPLQIETYGPHVPELEMLGRLGGFDTISLI 250 260 270 pF1KB6 FSGLFWQPS >>NP_001171434 (OMIM: 602659) CDK-activating kinase asse (267 aa) initn: 1241 init1: 1241 opt: 1244 Z-score: 837.1 bits: 162.8 E(85289): 6.9e-40 Smith-Waterman score: 1697; 86.4% identity (86.4% similar) in 309 aa overlap (1-309:1-267) 10 20 30 40 50 60 pF1KB6 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK ::::::: ::::::::::: NP_001 QAFLDEL------------------------------------------GQHISLAPIHK 190 250 260 270 280 290 300 pF1KB6 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA 200 210 220 230 240 250 pF1KB6 FSGLFWQPS ::::::::: NP_001 FSGLFWQPS 260 >>XP_016876823 (OMIM: 602659) PREDICTED: CDK-activating (188 aa) initn: 1225 init1: 1225 opt: 1225 Z-score: 826.7 bits: 160.4 E(85289): 2.6e-39 Smith-Waterman score: 1225; 100.0% identity (100.0% similar) in 188 aa overlap (122-309:1-188) 100 110 120 130 140 150 pF1KB6 LREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEAL :::::::::::::::::::::::::::::: XP_016 MEIYQKENKDVIQKNKLKLTREQEELEEAL 10 20 30 160 170 180 190 200 210 pF1KB6 EVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQ 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 LEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGY 100 110 120 130 140 150 280 290 300 pF1KB6 LNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS :::::::::::::::::::::::::::::::::::::: XP_016 LNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS 160 170 180 >>XP_016876822 (OMIM: 602659) PREDICTED: CDK-activating (188 aa) initn: 1225 init1: 1225 opt: 1225 Z-score: 826.7 bits: 160.4 E(85289): 2.6e-39 Smith-Waterman score: 1225; 100.0% identity (100.0% similar) in 188 aa overlap (122-309:1-188) 100 110 120 130 140 150 pF1KB6 LREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEAL :::::::::::::::::::::::::::::: XP_016 MEIYQKENKDVIQKNKLKLTREQEELEEAL 10 20 30 160 170 180 190 200 210 pF1KB6 EVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQ 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 LEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGY 100 110 120 130 140 150 280 290 300 pF1KB6 LNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS :::::::::::::::::::::::::::::::::::::: XP_016 LNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS 160 170 180 309 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:52:57 2016 done: Fri Nov 4 20:52:58 2016 Total Scan time: 7.350 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]