Result of FASTA (omim) for pF1KE0996
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0996, 659 aa
  1>>>pF1KE0996     659 - 659 aa - 659 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.4809+/-0.000551; mu= -2.8817+/- 0.034
 mean_var=719.4331+/-162.037, 0's: 0 Z-trim(118.6): 1356  B-trim: 1846 in 1/57
 Lambda= 0.047817
 statistics sampled from 31394 (33089) to 31394 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.358), width:  16
 Scan time:  5.620

The best scores are:                                      opt bits E(92320)
NP_000052 (OMIM: 300300,300755,307200) tyrosine-pr ( 659) 4462 324.4 9.2e-88
NP_001274273 (OMIM: 300300,300755,307200) tyrosine ( 693) 4462 324.4 9.4e-88
NP_001274274 (OMIM: 300300,300755,307200) tyrosine ( 483) 2360 179.1 3.5e-44
XP_016864058 (OMIM: 600583) tyrosine-protein kinas ( 515) 1981 153.0 2.7e-36
XP_011512039 (OMIM: 600583) tyrosine-protein kinas ( 595) 1981 153.1 2.9e-36
XP_024309961 (OMIM: 600583) tyrosine-protein kinas ( 631) 1981 153.2   3e-36
NP_003206 (OMIM: 600583) tyrosine-protein kinase T ( 631) 1981 153.2   3e-36
NP_003319 (OMIM: 600058) tyrosine-protein kinase T ( 527) 1933 149.7 2.7e-35
XP_024309968 (OMIM: 600058) tyrosine-protein kinas ( 530) 1917 148.6 5.8e-35
XP_016864070 (OMIM: 600058) tyrosine-protein kinas ( 502) 1915 148.5 6.2e-35
XP_016864932 (OMIM: 186973,613011) tyrosine-protei ( 495) 1790 139.8 2.4e-32
NP_005537 (OMIM: 186973,613011) tyrosine-protein k ( 620) 1790 140.0 2.7e-32
NP_001307795 (OMIM: 300101) cytoplasmic tyrosine-p ( 674) 1722 135.4 7.4e-31
NP_001712 (OMIM: 300101) cytoplasmic tyrosine-prot ( 675) 1722 135.4 7.4e-31
NP_975010 (OMIM: 300101) cytoplasmic tyrosine-prot ( 675) 1722 135.4 7.4e-31
XP_011512049 (OMIM: 600058) tyrosine-protein kinas ( 508) 1659 130.8 1.3e-29
XP_016864071 (OMIM: 600058) tyrosine-protein kinas ( 338) 1466 117.2 1.1e-25
XP_011512050 (OMIM: 600058) tyrosine-protein kinas ( 289) 1303 105.8 2.4e-22
XP_011512043 (OMIM: 600583) tyrosine-protein kinas ( 466) 1236 101.6 7.6e-21
NP_005148 (OMIM: 189980,608232,617602) tyrosine-pr (1130) 1171 97.7 2.6e-19
NP_009297 (OMIM: 189980,608232,617602) tyrosine-pr (1149) 1171 97.7 2.7e-19
NP_001129472 (OMIM: 164690) tyrosine-protein kinas (1064) 1153 96.4 6.1e-19
NP_005149 (OMIM: 164690) tyrosine-protein kinase A (1167) 1153 96.5 6.3e-19
NP_001129473 (OMIM: 164690) tyrosine-protein kinas ( 542) 1142 95.2 7.3e-19
XP_024302814 (OMIM: 153390,615758) tyrosine-protei ( 567) 1142 95.2 7.5e-19
XP_024302815 (OMIM: 153390,615758) tyrosine-protei ( 567) 1142 95.2 7.5e-19
NP_001161709 (OMIM: 164690) tyrosine-protein kinas (1079) 1147 96.0 8.1e-19
NP_009298 (OMIM: 164690) tyrosine-protein kinase A (1182) 1147 96.1 8.5e-19
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 1138 94.9 8.6e-19
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 1138 94.9 8.6e-19
XP_016856524 (OMIM: 164690) tyrosine-protein kinas (1182) 1146 96.0 8.9e-19
NP_001161711 (OMIM: 164690) tyrosine-protein kinas (1043) 1142 95.7   1e-18
NP_001161710 (OMIM: 164690) tyrosine-protein kinas (1058) 1142 95.7   1e-18
XP_005245145 (OMIM: 164690) tyrosine-protein kinas (1146) 1142 95.7 1.1e-18
NP_001161708 (OMIM: 164690) tyrosine-protein kinas (1161) 1142 95.7 1.1e-18
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 1133 94.5 1.1e-18
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 1133 94.5 1.1e-18
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 1131 94.4 1.2e-18
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 1131 94.4 1.2e-18
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 1131 94.4 1.2e-18
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 1131 94.4 1.2e-18
XP_005266937 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_011533957 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_016866134 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_011533955 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1117 93.4 2.3e-18
XP_005266938 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_011533956 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
XP_005266939 (OMIM: 606573) tyrosine-protein kinas ( 505) 1117 93.4 2.3e-18
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 1114 93.2 2.7e-18


>>NP_000052 (OMIM: 300300,300755,307200) tyrosine-protei  (659 aa)
 initn: 4462 init1: 4462 opt: 4462  Z-score: 1697.3  bits: 324.4 E(92320): 9.2e-88
Smith-Waterman score: 4462; 100.0% identity (100.0% similar) in 659 aa overlap (1-659:1-659)

               10        20        30        40        50        60
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
              550       560       570       580       590       600

              610       620       630       640       650         
pF1KE0 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
              610       620       630       640       650         

>>NP_001274273 (OMIM: 300300,300755,307200) tyrosine-pro  (693 aa)
 initn: 4462 init1: 4462 opt: 4462  Z-score: 1697.1  bits: 324.4 E(92320): 9.4e-88
Smith-Waterman score: 4462; 100.0% identity (100.0% similar) in 659 aa overlap (1-659:35-693)

                                             10        20        30
pF1KE0                               MAAVILESIFLKRSQQKKKTSPLNFKKRLF
                                     ::::::::::::::::::::::::::::::
NP_001 SIQQMVIGCPLCGRHCSGGEHTGELQKEEAMAAVILESIFLKRSQQKKKTSPLNFKKRLF
           10        20        30        40        50        60    

               40        50        60        70        80        90
pF1KE0 LLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEME
           70        80        90       100       110       120    

              100       110       120       130       140       150
pF1KE0 QISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDG
          130       140       150       160       170       180    

              160       170       180       190       200       210
pF1KE0 QYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAP
          190       200       210       220       230       240    

              220       230       240       250       260       270
pF1KE0 VSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT
          250       260       270       280       290       300    

              280       290       300       310       320       330
pF1KE0 EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGV
          310       320       330       340       350       360    

              340       350       360       370       380       390
pF1KE0 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGL
          370       380       390       400       410       420    

              400       410       420       430       440       450
pF1KE0 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMM
          430       440       450       460       470       480    

              460       470       480       490       500       510
pF1KE0 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME
          490       500       510       520       530       540    

              520       530       540       550       560       570
pF1KE0 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM
          550       560       570       580       590       600    

              580       590       600       610       620       630
pF1KE0 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM
          610       620       630       640       650       660    

              640       650         
pF1KE0 YSCWHEKADERPTFKILLSNILDVMDEES
       :::::::::::::::::::::::::::::
NP_001 YSCWHEKADERPTFKILLSNILDVMDEES
          670       680       690   

>>NP_001274274 (OMIM: 300300,300755,307200) tyrosine-pro  (483 aa)
 initn: 2402 init1: 2360 opt: 2360  Z-score: 914.8  bits: 179.1 E(92320): 3.5e-44
Smith-Waterman score: 2915; 73.3% identity (73.3% similar) in 659 aa overlap (1-659:1-483)

               10        20        30        40        50        60
pF1KE0 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
       :::::::::::::::::::::::::::::::::::::::::::::::             
NP_001 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLA-------------
              310       320       330       340                    

              370       380       390       400       410       420
pF1KE0 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              430       440       450       460       470       480
pF1KE0 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              490       500       510       520       530       540
pF1KE0 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
                                                  :::::::::::::::::
NP_001 -------------------------------------------ARNCLVNDQGVVKVSDF
                                                  350       360    

              550       560       570       580       590       600
pF1KE0 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
          370       380       390       400       410       420    

              610       620       630       640       650         
pF1KE0 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
          430       440       450       460       470       480   

>>XP_016864058 (OMIM: 600583) tyrosine-protein kinase Te  (515 aa)
 initn: 2090 init1: 1469 opt: 1981  Z-score: 773.2  bits: 153.0 E(92320): 2.7e-36
Smith-Waterman score: 2087; 56.4% identity (82.1% similar) in 521 aa overlap (141-658:3-510)

              120       130       140       150       160       170
pF1KE0 LYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILEN
                                     :::: :: ::.: :: :: : : ::.  . 
XP_016                             MIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNL
                                           10        20        30  

              180       190       200       210       220       230
pF1KE0 RNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNA
        ..:..         : :::.::  .  ..: :: :     .. :.  :::.::..  ..
XP_016 FESSIR---------KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEG
                      40          50        60          70         

              240       250       260       270        280         
pF1KE0 NDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRS
       .::.:..:.::.:::.... ::::::: :.:::::::::: .  .....:::: ..:.::
XP_016 HDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRS
      80        90       100       110       120       130         

     290       300       310       320       330       340         
pF1KE0 QAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLA
       .:::::..: :::::.:::::. : ::::...:  :. .. .::: .  :  :  .::::
XP_016 KAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLA
     140       150       160       170       180       190         

       350       360       370       380       390       400       
pF1KE0 EKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKE
       ::: :..:::.:.::.::.:::..::.:::: ..::::.:::..: .:::.:..:::..:
XP_016 EKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRE
     200       210       220       230       240       250         

       410       420       430       440       450       460       
pF1KE0 LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ
       ::.: ::::. ::::.:: :::: :.::.: :..:::::::::.:.: ::::::::::.:
XP_016 LGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQ
     260       270       280       290       300       310         

       470       480       490       500       510       520       
pF1KE0 RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNC
       .::.:.::.:  :::::.::. . .:. . :: ::.::::.::::: ..:.:::::::::
XP_016 KPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNC
     320       330       340       350       360       370         

       530       540       550       560       570       580       
pF1KE0 LVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLM
       ::.. :::::::::..::::::.:::: :.::::.: ::::. ::.::::::.:.:::::
XP_016 LVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLM
     380       390       400       410       420       430         

       590       600       610       620       630       640       
pF1KE0 WEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKIL
       ::... :.::.:..:: :..  ...: :::.:.:::. :: .:  ::.:: . ::.:. :
XP_016 WEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDL
     440       450       460       470       480       490         

       650             
pF1KE0 LSNILDVMDEES    
       : .: .... :     
XP_016 LRTIDELVECEETFGR
     500       510     

>>XP_011512039 (OMIM: 600583) tyrosine-protein kinase Te  (595 aa)
 initn: 2018 init1: 1469 opt: 1981  Z-score: 772.7  bits: 153.1 E(92320): 2.9e-36
Smith-Waterman score: 2242; 53.4% identity (78.7% similar) in 610 aa overlap (52-658:14-590)

              30        40        50        60        70        80 
pF1KE0 PLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPR
                                     .:: ::: :: ::: :   ::   .  :: 
XP_011                  MKSGNSIHHQKKYRKGFIDVSKIKCVEIV---KN--DDGVIPC
                                10        20           30          

              90       100       110       120       130       140 
pF1KE0 RGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQK
       ...               ::::::.: . ::.:.:. . :  :...::. :. :.... :
XP_011 QNK---------------YPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK
       40                       50        60        70        80   

             150       160       170       180       190       200 
pF1KE0 YHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKP
       ::: :: ::.: :: :: : : ::.  .  ..:..         : :::.::  .  ..:
XP_011 YHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR---------KALPPAPETKK--RRP
            90       100       110                120         130  

             210       220       230       240       250       260 
pF1KE0 LPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQE
        :: :     .. :.  :::.::..  ...::.:..:.::.:::.... ::::::: :.:
XP_011 PPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNE
            140         150       160       170       180       190

             270        280       290       300       310       320
pF1KE0 GYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVF
       ::::::::: .  .....:::: ..:.::.:::::..: :::::.:::::. : ::::..
XP_011 GYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLY
              200       210       220       230       240       250

              330       340         350       360       370        
pF1KE0 AKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVS
       .:  :. .. .::: .  :  :  .::::::: :..:::.:.::.::.:::..::.::::
XP_011 TKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVS
              260       270       280       290       300       310

      380       390       400       410       420       430        
pF1KE0 QQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMS
        ..::::.:::..: .:::.:..:::..:::.: ::::. ::::.:: :::: :.::.: 
XP_011 VKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMC
              320       330       340       350       360       370

      440       450       460       470       480       490        
pF1KE0 EDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQL
       :..:::::::::.:.: ::::::::::.:.::.:.::.:  :::::.::. . .:. . :
XP_011 EEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVL
              380       390       400       410       420       430

      500       510       520       530       540       550        
pF1KE0 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK
       : ::.::::.::::: ..:.:::::::::::.. :::::::::..::::::.:::: :.:
XP_011 LSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK
              440       450       460       470       480       490

      560       570       580       590       600       610        
pF1KE0 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR
       :::.: ::::. ::.::::::.:.:::::::... :.::.:..:: :..  ...: :::.
XP_011 FPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQ
              500       510       520       530       540       550

      620       630       640       650             
pF1KE0 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES    
       :.:::. :: .:  ::.:: . ::.:. :: .: .... :     
XP_011 PKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR
              560       570       580       590     

>>XP_024309961 (OMIM: 600583) tyrosine-protein kinase Te  (631 aa)
 initn: 2174 init1: 1469 opt: 1981  Z-score: 772.4  bits: 153.2 E(92320): 3e-36
Smith-Waterman score: 2399; 53.9% identity (78.7% similar) in 657 aa overlap (5-658:6-626)

                10        20        30        40        50         
pF1KE0  MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVE
            ::: :..:::::::::::::.:.:::.::   :.:::    :...  .:: ::: 
XP_024 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVS
               10        20        30        40           50       

      60        70        80        90       100       110         
pF1KE0 KITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEE
       :: ::: :   ::   .  :: ...               ::::::.: . ::.:.:. .
XP_024 KIKCVEIV---KN--DDGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQ
        60             70                       80        90       

     120       130       140       150       160       170         
pF1KE0 LRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGS
        :  :...::. :. :.... :::: :: ::.: :: :: : : ::.  .  ..:..   
XP_024 SRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR---
       100       110       120       130       140       150       

     180       190       200       210       220       230         
pF1KE0 SHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGD
             : :::.::  .  ..: :: :     .. :.  :::.::..  ...::.:..:.
XP_024 ------KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQ
                160         170       180         190       200    

     240       250       260       270        280       290        
pF1KE0 EYFILEESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQE
       ::.:::.... ::::::: :.:::::::::: .  .....:::: ..:.::.:::::..:
XP_024 EYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSE
          210       220       230       240       250       260    

      300       310       320       330       340         350      
pF1KE0 GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIP
        :::::.:::::. : ::::...:  :. .. .::: .  :  :  .::::::: :..::
XP_024 DKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIP
          270       280       290       300       310       320    

        360       370       380       390       400       410      
pF1KE0 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVV
       :.:.::.::.:::..::.:::: ..::::.:::..: .:::.:..:::..:::.: ::::
XP_024 EIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVV
          330       340       350       360       370       380    

        420       430       440       450       460       470      
pF1KE0 KYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEY
       . ::::.:: :::: :.::.: :..:::::::::.:.: ::::::::::.:.::.:.::.
XP_024 RLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEF
          390       400       410       420       430       440    

        480       490       500       510       520       530      
pF1KE0 MANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVK
       :  :::::.::. . .:. . :: ::.::::.::::: ..:.:::::::::::.. ::::
XP_024 MERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVK
          450       460       470       480       490       500    

        540       550       560       570       580       590      
pF1KE0 VSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKM
       :::::..::::::.:::: :.::::.: ::::. ::.::::::.:.:::::::... :.:
XP_024 VSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRM
          510       520       530       540       550       560    

        600       610       620       630       640       650      
pF1KE0 PYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD
       :.:..:: :..  ...: :::.:.:::. :: .:  ::.:: . ::.:. :: .: ....
XP_024 PFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE
          570       580       590       600       610       620    

              
pF1KE0 EES    
        :     
XP_024 CEETFGR
          630 

>>NP_003206 (OMIM: 600583) tyrosine-protein kinase Tec [  (631 aa)
 initn: 2174 init1: 1469 opt: 1981  Z-score: 772.4  bits: 153.2 E(92320): 3e-36
Smith-Waterman score: 2399; 53.9% identity (78.7% similar) in 657 aa overlap (5-658:6-626)

                10        20        30        40        50         
pF1KE0  MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVE
            ::: :..:::::::::::::.:.:::.::   :.:::    :...  .:: ::: 
NP_003 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVS
               10        20        30        40           50       

      60        70        80        90       100       110         
pF1KE0 KITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEE
       :: ::: :   ::   .  :: ...               ::::::.: . ::.:.:. .
NP_003 KIKCVEIV---KN--DDGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQ
        60             70                       80        90       

     120       130       140       150       160       170         
pF1KE0 LRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGS
        :  :...::. :. :.... :::: :: ::.: :: :: : : ::.  .  ..:..   
NP_003 SRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR---
       100       110       120       130       140       150       

     180       190       200       210       220       230         
pF1KE0 SHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGD
             : :::.::  .  ..: :: :     .. :.  :::.::..  ...::.:..:.
NP_003 ------KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQ
                160         170       180         190       200    

     240       250       260       270        280       290        
pF1KE0 EYFILEESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQE
       ::.:::.... ::::::: :.:::::::::: .  .....:::: ..:.::.:::::..:
NP_003 EYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSE
          210       220       230       240       250       260    

      300       310       320       330       340         350      
pF1KE0 GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIP
        :::::.:::::. : ::::...:  :. .. .::: .  :  :  .::::::: :..::
NP_003 DKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIP
          270       280       290       300       310       320    

        360       370       380       390       400       410      
pF1KE0 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVV
       :.:.::.::.:::..::.:::: ..::::.:::..: .:::.:..:::..:::.: ::::
NP_003 EIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVV
          330       340       350       360       370       380    

        420       430       440       450       460       470      
pF1KE0 KYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEY
       . ::::.:: :::: :.::.: :..:::::::::.:.: ::::::::::.:.::.:.::.
NP_003 RLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEF
          390       400       410       420       430       440    

        480       490       500       510       520       530      
pF1KE0 MANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVK
       :  :::::.::. . .:. . :: ::.::::.::::: ..:.:::::::::::.. ::::
NP_003 MERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVK
          450       460       470       480       490       500    

        540       550       560       570       580       590      
pF1KE0 VSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKM
       :::::..::::::.:::: :.::::.: ::::. ::.::::::.:.:::::::... :.:
NP_003 VSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRM
          510       520       530       540       550       560    

        600       610       620       630       640       650      
pF1KE0 PYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD
       :.:..:: :..  ...: :::.:.:::. :: .:  ::.:: . ::.:. :: .: ....
NP_003 PFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE
          570       580       590       600       610       620    

              
pF1KE0 EES    
        :     
NP_003 CEETFGR
          630 

>>NP_003319 (OMIM: 600058) tyrosine-protein kinase TXK [  (527 aa)
 initn: 1928 init1: 1657 opt: 1933  Z-score: 755.3  bits: 149.7 E(92320): 2.7e-35
Smith-Waterman score: 1933; 52.9% identity (80.5% similar) in 512 aa overlap (154-656:17-525)

           130       140       150       160       170       180   
pF1KE0 WIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRK
                                     :: .. :  :  ::  . .  :    ..:.
NP_003               MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRR
                             10        20        30        40      

                  190       200       210        220       230     
pF1KE0 -------TKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELK-KVVALYDYMPMNANDLQL
              ..:    : . .   .::::: :   :  ..: : .: ::::..: .  .: :
NP_003 RPWLSQLSNKKQSNTGRVQPSKRKPLPPLP---PSEVAEEKIQVKALYDFLPREPCNLAL
         50        60        70           80        90       100   

         240       250       260       270        280       290    
pF1KE0 RKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAE-DSIEMYEWYSKHMTRSQAEQL
       :...::.:::. :  ::.:::. :.:: :::::::: .  ..:.:::: ...::.:::.:
NP_003 RRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHL
           110       120       130       140       150       160   

          300       310       320       330       340       350    
pF1KE0 LKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFST
       :.::.:::.:::::: . :.::.:::  .  . ...:.:: . .. ..:.:.::.: :..
NP_003 LRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQS
           170       180       190       200       210       220   

          360       370       380       390       400       410    
pF1KE0 IPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFG
       ::::: :::::.:::..::.:::. ...  :.:::..: .:::::..:.:.::.:.::::
NP_003 IPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFG
           230       240       250       260       270       280   

          420       430       440       450       460       470    
pF1KE0 VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIIT
       ::. :.::.. .:::: :.::::::..:::::::::.::: ::::::::: ...:..:.:
NP_003 VVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVT
           290       300       310       320       330       340   

          480       490       500       510       520       530    
pF1KE0 EYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV
       :.: :::::::::: . ... ..:: .:.:.::.::::: . ..:::::::::::..  .
NP_003 EFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCI
           350       360       370       380       390       400   

          540       550       560       570       580       590    
pF1KE0 VKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG
       ::.::::..::::::::.:: :.:::..::::::....:.:::::.:.:::::::... :
NP_003 VKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEG
           410       420       430       440       450       460   

          600       610       620       630       640       650    
pF1KE0 KMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDV
       :::.:  .: ...: :..:.::::::::  ..: .:::::::: . ::::  ::  . ..
NP_003 KMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI
           470       480       490       500       510       520   

            
pF1KE0 MDEES
        .   
NP_003 AETW 
            

>>XP_024309968 (OMIM: 600058) tyrosine-protein kinase TX  (530 aa)
 initn: 1899 init1: 1657 opt: 1917  Z-score: 749.3  bits: 148.6 E(92320): 5.8e-35
Smith-Waterman score: 1917; 52.3% identity (80.5% similar) in 518 aa overlap (144-656:15-528)

           120       130       140       150       160          170
pF1KE0 FSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKN---AMGCQILEN
                                     ::..:  ..    :   .   .   .. :.
XP_024                 MVELGFKLLFLITIPCLFITKRHHQMRQMRTQISLSTDEELPEK
                               10        20        30        40    

              180       190       200       210        220         
pF1KE0 RNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELK-KVVALYDYMPMN
        .   .:  :. ..::    : . .   .::::: :   :  ..: : .: ::::..: .
XP_024 YTQRRRPWLSQLSNKKQ-SNTGRVQPSKRKPLPPLP---PSEVAEEKIQVKALYDFLPRE
           50        60         70           80        90       100

     230       240       250       260       270        280        
pF1KE0 ANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAE-DSIEMYEWYSKHMTR
         .: ::...::.:::. :  ::.:::. :.:: :::::::: .  ..:.:::: ...::
XP_024 PCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITR
              110       120       130       140       150       160

      290       300       310       320       330       340        
pF1KE0 SQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAE
       .:::.::.::.:::.:::::: . :.::.:::  .  . ...:.:: . .. ..:.:.::
XP_024 NQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAE
              170       180       190       200       210       220

      350       360       370       380       390       400        
pF1KE0 KHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKEL
       .: :..::::: :::::.:::..::.:::. ...  :.:::..: .:::::..:.:.::.
XP_024 RHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEI
              230       240       250       260       270       280

      410       420       430       440       450       460        
pF1KE0 GTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR
       :.::::::. :.::.. .:::: :.::::::..:::::::::.::: ::::::::: ...
XP_024 GSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRK
              290       300       310       320       330       340

      470       480       490       500       510       520        
pF1KE0 PIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCL
       :..:.::.: :::::::::: . ... ..:: .:.:.::.::::: . ..::::::::::
XP_024 PLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCL
              350       360       370       380       390       400

      530       540       550       560       570       580        
pF1KE0 VNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMW
       :..  .::.::::..::::::::.:: :.:::..::::::....:.:::::.:.::::::
XP_024 VSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMW
              410       420       430       440       450       460

      590       600       610       620       630       640        
pF1KE0 EIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILL
       :... ::::.:  .: ...: :..:.::::::::  ..: .:::::::: . ::::  ::
XP_024 EVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELL
              470       480       490       500       510       520

      650         
pF1KE0 SNILDVMDEES
         . .. .   
XP_024 RAVTEIAETW 
              530 

>>XP_016864070 (OMIM: 600058) tyrosine-protein kinase TX  (502 aa)
 initn: 1899 init1: 1657 opt: 1915  Z-score: 748.7  bits: 148.5 E(92320): 6.2e-35
Smith-Waterman score: 1915; 56.7% identity (85.0% similar) in 460 aa overlap (199-656:44-500)

      170       180       190       200       210        220       
pF1KE0 ENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELK-KVVALYDYMP
                                     .::::: :   :  ..: : .: ::::..:
XP_016 PEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLP---PSEVAEEKIQVKALYDFLP
            20        30        40        50           60        70

       230       240       250       260       270        280      
pF1KE0 MNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAE-DSIEMYEWYSKHM
        .  .: ::...::.:::. :  ::.:::. :.:: :::::::: .  ..:.:::: ...
XP_016 REPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNI
               80        90       100       110       120       130

        290       300       310       320       330       340      
pF1KE0 TRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYL
       ::.:::.::.::.:::.:::::: . :.::.:::  .  . ...:.:: . .. ..:.:.
XP_016 TRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYV
              140       150       160       170       180       190

        350       360       370       380       390       400      
pF1KE0 AEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLK
       ::.: :..::::: :::::.:::..::.:::. ...  :.:::..: .:::::..:.:.:
XP_016 AERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIK
              200       210       220       230       240       250

        410       420       430       440       450       460      
pF1KE0 ELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTK
       :.:.::::::. :.::.. .:::: :.::::::..:::::::::.::: ::::::::: .
XP_016 EIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQ
              260       270       280       290       300       310

        470       480       490       500       510       520      
pF1KE0 QRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN
       ..:..:.::.: :::::::::: . ... ..:: .:.:.::.::::: . ..::::::::
XP_016 RKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARN
              320       330       340       350       360       370

        530       540       550       560       570       580      
pF1KE0 CLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVL
       :::..  .::.::::..::::::::.:: :.:::..::::::....:.:::::.:.::::
XP_016 CLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVL
              380       390       400       410       420       430

        590       600       610       620       630       640      
pF1KE0 MWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKI
       :::... ::::.:  .: ...: :..:.::::::::  ..: .:::::::: . ::::  
XP_016 MWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAE
              440       450       460       470       480       490

        650         
pF1KE0 LLSNILDVMDEES
       ::  . .. .   
XP_016 LLRAVTEIAETW 
              500   




659 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:27:16 2019 done: Thu Oct 24 21:27:17 2019
 Total Scan time:  5.620 Total Display time:  0.100

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com