Result of FASTA (omim) for pF1KF0141
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KF0141, 1319 aa
  1>>>pF1KF0141 1319 - 1319 aa - 1319 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 16.4352+/-0.000471; mu= -30.1585+/- 0.029
 mean_var=581.6718+/-120.477, 0's: 0 Z-trim(122.9): 59  B-trim: 604 in 1/57
 Lambda= 0.053178
 statistics sampled from 41839 (41901) to 41839 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.491), width:  16
 Scan time: 21.090

The best scores are:                                      opt bits E(85289)
NP_001138231 (OMIM: 612834) pleckstrin homology-li (1319) 8663 680.5 2.1e-194
XP_005271531 (OMIM: 612834) PREDICTED: pleckstrin  (1365) 8663 680.5 2.2e-194
XP_005271530 (OMIM: 612834) PREDICTED: pleckstrin  (1376) 8347 656.2 4.4e-187
XP_005271529 (OMIM: 612834) PREDICTED: pleckstrin  (1391) 6514 515.6 9.6e-145
XP_016872899 (OMIM: 612834) PREDICTED: pleckstrin  (1495) 6043 479.5 7.7e-134
XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin  (1543) 6008 476.8 5.1e-133
NP_001138230 (OMIM: 612834) pleckstrin homology-li (1377) 5996 475.9 8.7e-133
NP_055972 (OMIM: 612834) pleckstrin homology-like  (1377) 5996 475.9 8.7e-133
XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin  (1412) 5996 475.9 8.9e-133
XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin  (1423) 5996 475.9  9e-133
XP_005271526 (OMIM: 612834) PREDICTED: pleckstrin  (1427) 5996 475.9  9e-133
XP_005271525 (OMIM: 612834) PREDICTED: pleckstrin  (1438) 5996 475.9 9.1e-133
XP_016872896 (OMIM: 612834) PREDICTED: pleckstrin  (1542) 5991 475.5 1.3e-132
XP_016872898 (OMIM: 612834) PREDICTED: pleckstrin  (1503) 5363 427.3 3.9e-118
XP_011541012 (OMIM: 612834) PREDICTED: pleckstrin  (1529) 5360 427.1 4.7e-118
XP_006718866 (OMIM: 612834) PREDICTED: pleckstrin  (1408) 5321 424.1 3.5e-117
XP_006718865 (OMIM: 612834) PREDICTED: pleckstrin  (1419) 5321 424.1 3.5e-117
XP_006718864 (OMIM: 612834) PREDICTED: pleckstrin  (1434) 5321 424.1 3.5e-117
XP_006718863 (OMIM: 612834) PREDICTED: pleckstrin  (1455) 5321 424.1 3.6e-117
XP_006718862 (OMIM: 612834) PREDICTED: pleckstrin  (1466) 5321 424.1 3.6e-117
XP_006718861 (OMIM: 612834) PREDICTED: pleckstrin  (1481) 5321 424.1 3.6e-117
XP_016872897 (OMIM: 612834) PREDICTED: pleckstrin  (1512) 5321 424.1 3.7e-117
XP_006718860 (OMIM: 612834) PREDICTED: pleckstrin  (1538) 5321 424.1 3.7e-117
XP_011541010 (OMIM: 612834) PREDICTED: pleckstrin  (1540) 5321 424.1 3.7e-117
XP_011541011 (OMIM: 612834) PREDICTED: pleckstrin  (1540) 5321 424.1 3.7e-117
XP_011541008 (OMIM: 612834) PREDICTED: pleckstrin  (1560) 5321 424.1 3.8e-117
XP_011541007 (OMIM: 612834) PREDICTED: pleckstrin  (1571) 5321 424.1 3.8e-117
XP_011541006 (OMIM: 612834) PREDICTED: pleckstrin  (1575) 5321 424.1 3.8e-117
XP_011541005 (OMIM: 612834) PREDICTED: pleckstrin  (1586) 5321 424.1 3.8e-117
XP_006718859 (OMIM: 612834) PREDICTED: pleckstrin  (1539) 5304 422.8 9.2e-117
XP_005277737 (OMIM: 612834) PREDICTED: pleckstrin  (1585) 5304 422.8 9.5e-117
XP_011541016 (OMIM: 612834) PREDICTED: pleckstrin  ( 848) 5269 420.0 3.5e-116
XP_005271532 (OMIM: 612834) PREDICTED: pleckstrin  ( 858) 5263 419.5 4.9e-116
XP_016872900 (OMIM: 612834) PREDICTED: pleckstrin  ( 858) 5263 419.5 4.9e-116
XP_011541017 (OMIM: 612834) PREDICTED: pleckstrin  ( 721) 4558 365.4  8e-100
XP_011541013 (OMIM: 612834) PREDICTED: pleckstrin  (1420) 4509 361.8   2e-98
XP_011541015 (OMIM: 612834) PREDICTED: pleckstrin  (1419) 4492 360.5 4.9e-98
NP_665696 (OMIM: 610298) pleckstrin homology-like  (1210) 1419 124.7   4e-27
NP_001127909 (OMIM: 610298) pleckstrin homology-li (1237) 1419 124.7   4e-27
NP_001127910 (OMIM: 610298) pleckstrin homology-li (1253) 1366 120.6 6.8e-26
NP_001127911 (OMIM: 610298) pleckstrin homology-li (1253) 1366 120.6 6.8e-26


>>NP_001138231 (OMIM: 612834) pleckstrin homology-like d  (1319 aa)
 initn: 8663 init1: 8663 opt: 8663  Z-score: 3611.0  bits: 680.5 E(85289): 2.1e-194
Smith-Waterman score: 8663; 100.0% identity (100.0% similar) in 1319 aa overlap (1-1319:1-1319)

               10        20        30        40        50        60
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KF0 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KF0 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KF0 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KF0 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KF0 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KF0 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KF0 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KF0 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KF0 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KF0 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KF0 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KF0 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KF0 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KF0 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KF0 RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KF0 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KF0 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KF0 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KF0 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KF0 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310         
pF1KF0 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
             1270      1280      1290      1300      1310         

>>XP_005271531 (OMIM: 612834) PREDICTED: pleckstrin homo  (1365 aa)
 initn: 8663 init1: 8663 opt: 8663  Z-score: 3610.8  bits: 680.5 E(85289): 2.2e-194
Smith-Waterman score: 8663; 100.0% identity (100.0% similar) in 1319 aa overlap (1-1319:47-1365)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KF0 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
        980       990      1000      1010      1020      1030      

             1000      1010      1020      1030      1040      1050
pF1KF0 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
       1040      1050      1060      1070      1080      1090      

             1060      1070      1080      1090      1100      1110
pF1KF0 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
       1100      1110      1120      1130      1140      1150      

             1120      1130      1140      1150      1160      1170
pF1KF0 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
       1160      1170      1180      1190      1200      1210      

             1180      1190      1200      1210      1220      1230
pF1KF0 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
       1220      1230      1240      1250      1260      1270      

             1240      1250      1260      1270      1280      1290
pF1KF0 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLY
       1280      1290      1300      1310      1320      1330      

             1300      1310         
pF1KF0 YMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       :::::::::::::::::::::::::::::
XP_005 YMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       1340      1350      1360     

>>XP_005271530 (OMIM: 612834) PREDICTED: pleckstrin homo  (1376 aa)
 initn: 8347 init1: 8347 opt: 8347  Z-score: 3479.7  bits: 656.2 E(85289): 4.4e-187
Smith-Waterman score: 8631; 99.2% identity (99.2% similar) in 1330 aa overlap (1-1319:47-1376)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KF0 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
        980       990      1000      1010      1020      1030      

             1000      1010      1020      1030      1040      1050
pF1KF0 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
       1040      1050      1060      1070      1080      1090      

             1060      1070      1080      1090      1100      1110
pF1KF0 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
       1100      1110      1120      1130      1140      1150      

             1120      1130      1140      1150      1160      1170
pF1KF0 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
       1160      1170      1180      1190      1200      1210      

             1180      1190      1200      1210      1220      1230
pF1KF0 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
       1220      1230      1240      1250      1260      1270      

             1240      1250      1260      1270                    
pF1KF0 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNPAL
       :::::::::::::::::::::::::::::::::::::::::::           ::::::
XP_005 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPAL
       1280      1290      1300      1310      1320      1330      

    1280      1290      1300      1310         
pF1KF0 TFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       ::::::::::::::::::::::::::::::::::::::::
XP_005 TFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       1340      1350      1360      1370      

>>XP_005271529 (OMIM: 612834) PREDICTED: pleckstrin homo  (1391 aa)
 initn: 6792 init1: 6489 opt: 6514  Z-score: 2719.6  bits: 515.6 E(85289): 9.6e-145
Smith-Waterman score: 8591; 98.1% identity (98.1% similar) in 1345 aa overlap (1-1319:47-1391)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910       920       930
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
        920       930       940       950       960       970      

              940       950       960       970       980       990
pF1KF0 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
        980       990      1000      1010      1020      1030      

                            1000      1010      1020      1030     
pF1KF0 QQK---------------GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSG
       :::               ::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKVESLPAEPLPTDDPAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSG
       1040      1050      1060      1070      1080      1090      

        1040      1050      1060      1070      1080      1090     
pF1KF0 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG
       1100      1110      1120      1130      1140      1150      

        1100      1110      1120      1130      1140      1150     
pF1KF0 LDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQ
       1160      1170      1180      1190      1200      1210      

        1160      1170      1180      1190      1200      1210     
pF1KF0 QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGY
       1220      1230      1240      1250      1260      1270      

        1220      1230      1240      1250      1260      1270     
pF1KF0 LVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK--
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::  
XP_005 LVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKR
       1280      1290      1300      1310      1320      1330      

                   1280      1290      1300      1310         
pF1KF0 ---------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
                ::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
       1340      1350      1360      1370      1380      1390 

>>XP_016872899 (OMIM: 612834) PREDICTED: pleckstrin homo  (1495 aa)
 initn: 7830 init1: 5985 opt: 6043  Z-score: 2523.8  bits: 479.5 E(85289): 7.7e-134
Smith-Waterman score: 7825; 91.2% identity (91.2% similar) in 1351 aa overlap (1-1232:47-1397)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_016 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910                    
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_016 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEYVMLEQLKVMRGTSPMPP
        920       930       940       950       960       970      

                                                                   
pF1KF0 ------------------------------------------------------------
                                                                   
XP_016 APVPGLSPWASASRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAG
        980       990      1000      1010      1020      1030      

                                      920       930       940      
pF1KF0 --------------------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQ
                                 ::::::::::::::::::::::::::::::::::
XP_016 LGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQ
       1040      1050      1060      1070      1080      1090      

        950       960       970       980       990                
pF1KF0 LSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK-------------
       :::::::::::::::::::::::::::::::::::::::::::::::             
XP_016 LSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDD
       1100      1110      1120      1130      1140      1150      

            1000      1010      1020      1030      1040      1050 
pF1KF0 --GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAG
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAG
       1160      1170      1180      1190      1200      1210      

            1060      1070      1080      1090      1100      1110 
pF1KF0 RERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEA
       1220      1230      1240      1250      1260      1270      

            1120      1130      1140      1150      1160      1170 
pF1KF0 HAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQ
       1280      1290      1300      1310      1320      1330      

            1180      1190      1200      1210      1220      1230 
pF1KF0 ARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWF
       1340      1350      1360      1370      1380      1390      

            1240      1250      1260      1270      1280      1290 
pF1KF0 VFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYY
       :                                                           
XP_016 VFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALT
       1400      1410      1420      1430      1440      1450      

>--
 initn: 317 init1: 317 opt: 548  Z-score: 245.5  bits: 57.9 E(85289): 6.2e-07
Smith-Waterman score: 548; 88.8% identity (88.8% similar) in 98 aa overlap (1233-1319:1398-1495)

           1210      1220      1230      1240      1250      1260  
pF1KF0 LHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEE
                                     ::::::::::::::::::::::::::::::
XP_016 LHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEE
      1370      1380      1390      1400      1410      1420       

           1270                 1280      1290      1300      1310 
pF1KF0 VYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGA
       :::::::::::           ::::::::::::::::::::::::::::::::::::::
XP_016 VYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGA
      1430      1440      1450      1460      1470      1480       

               
pF1KF0 EGYTQFMN
       ::::::::
XP_016 EGYTQFMN
      1490     

>>XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin homo  (1543 aa)
 initn: 7830 init1: 5985 opt: 6008  Z-score: 2509.1  bits: 476.8 E(85289): 5.1e-133
Smith-Waterman score: 7391; 87.6% identity (87.6% similar) in 1351 aa overlap (1-1184:47-1397)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_011 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910                    
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_011 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKAL
        920       930       940       950       960       970      

                                                                   
pF1KF0 ------------------------------------------------------------
                                                                   
XP_011 GLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASA
        980       990      1000      1010      1020      1030      

                                                                   
pF1KF0 ------------------------------------------------------------
                                                                   
XP_011 SRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
       1040      1050      1060      1070      1080      1090      

                          920       930       940       950        
pF1KF0 --------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
                     ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
       1100      1110      1120      1130      1140      1150      

      960       970       980       990                     1000   
pF1KF0 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK---------------GQQVIEEQRR
       :::::::::::::::::::::::::::::::::::               ::::::::::
XP_011 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRR
       1160      1170      1180      1190      1200      1210      

          1010      1020      1030      1040      1050      1060   
pF1KF0 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       1220      1230      1240      1250      1260      1270      

          1070      1080      1090      1100      1110      1120   
pF1KF0 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       1280      1290      1300      1310      1320      1330      

          1130      1140      1150      1160      1170      1180   
pF1KF0 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       1340      1350      1360      1370      1380      1390      

          1190      1200      1210      1220      1230      1240   
pF1KF0 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       :                                                           
XP_011 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       1400      1410      1420      1430      1440      1450      

>--
 initn: 602 init1: 602 opt: 886  Z-score: 385.4  bits: 83.8 E(85289): 1e-14
Smith-Waterman score: 886; 92.5% identity (92.5% similar) in 146 aa overlap (1185-1319:1398-1543)

         1160      1170      1180      1190      1200      1210    
pF1KF0 QQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRG
                                     ::::::::::::::::::::::::::::::
XP_011 QQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRG
      1370      1380      1390      1400      1410      1420       

         1220      1230      1240      1250      1260      1270    
pF1KF0 YLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK-
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_011 YLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKK
      1430      1440      1450      1460      1470      1480       

                    1280      1290      1300      1310         
pF1KF0 ----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
                 ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
      1490      1500      1510      1520      1530      1540   

>>NP_001138230 (OMIM: 612834) pleckstrin homology-like d  (1377 aa)
 initn: 6290 init1: 5987 opt: 5996  Z-score: 2504.9  bits: 475.9 E(85289): 8.7e-133
Smith-Waterman score: 8353; 95.7% identity (95.7% similar) in 1351 aa overlap (1-1293:1-1351)

               10        20        30        40        50        60
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KF0 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KF0 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KF0 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KF0 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KF0 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KF0 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KF0 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KF0 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KF0 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KF0 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KF0 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KF0 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KF0 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KF0 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
              850       860       870       880       890       900

              910                                                  
pF1KF0 RPFPKTTSTLKE-----------------------------------------------V
       ::::::::::::                                               :
NP_001 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
              910       920       930       940       950       960

           920       930       940       950       960       970   
pF1KF0 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
              970       980       990      1000      1010      1020

           980       990      1000      1010      1020      1030   
pF1KF0 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
             1030      1040      1050      1060      1070      1080

          1040      1050      1060      1070      1080      1090   
pF1KF0 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
             1090      1100      1110      1120      1130      1140

          1100      1110      1120      1130      1140      1150   
pF1KF0 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
             1150      1160      1170      1180      1190      1200

          1160      1170      1180      1190      1200      1210   
pF1KF0 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
             1210      1220      1230      1240      1250      1260

          1220      1230      1240      1250      1260      1270   
pF1KF0 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
             1270      1280      1290      1300      1310      1320

                     1280      1290      1300      1310         
pF1KF0 -----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
                  ::::::::::::::::::::                          
NP_001 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
             1330      1340      1350      1360      1370       

>>NP_055972 (OMIM: 612834) pleckstrin homology-like doma  (1377 aa)
 initn: 6290 init1: 5987 opt: 5996  Z-score: 2504.9  bits: 475.9 E(85289): 8.7e-133
Smith-Waterman score: 8353; 95.7% identity (95.7% similar) in 1351 aa overlap (1-1293:1-1351)

               10        20        30        40        50        60
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KF0 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KF0 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KF0 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KF0 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KF0 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KF0 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KF0 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KF0 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KF0 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KF0 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KF0 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KF0 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KF0 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KF0 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
              850       860       870       880       890       900

              910                                                  
pF1KF0 RPFPKTTSTLKE-----------------------------------------------V
       ::::::::::::                                               :
NP_055 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
              910       920       930       940       950       960

           920       930       940       950       960       970   
pF1KF0 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
              970       980       990      1000      1010      1020

           980       990      1000      1010      1020      1030   
pF1KF0 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
             1030      1040      1050      1060      1070      1080

          1040      1050      1060      1070      1080      1090   
pF1KF0 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
             1090      1100      1110      1120      1130      1140

          1100      1110      1120      1130      1140      1150   
pF1KF0 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
             1150      1160      1170      1180      1190      1200

          1160      1170      1180      1190      1200      1210   
pF1KF0 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
             1210      1220      1230      1240      1250      1260

          1220      1230      1240      1250      1260      1270   
pF1KF0 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
             1270      1280      1290      1300      1310      1320

                     1280      1290      1300      1310         
pF1KF0 -----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
                  ::::::::::::::::::::                          
NP_055 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
             1330      1340      1350      1360      1370       

>>XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin homo  (1412 aa)
 initn: 5987 init1: 5987 opt: 5996  Z-score: 2504.7  bits: 475.9 E(85289): 8.9e-133
Smith-Waterman score: 8462; 96.5% identity (96.5% similar) in 1351 aa overlap (1-1304:47-1397)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910                    
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
        920       930       940       950       960       970      

                                         920       930       940   
pF1KF0 -----------------------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
                                    :::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
        980       990      1000      1010      1020      1030      

           950       960       970       980       990      1000   
pF1KF0 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       1040      1050      1060      1070      1080      1090      

          1010      1020      1030      1040      1050      1060   
pF1KF0 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       1100      1110      1120      1130      1140      1150      

          1070      1080      1090      1100      1110      1120   
pF1KF0 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       1160      1170      1180      1190      1200      1210      

          1130      1140      1150      1160      1170      1180   
pF1KF0 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       1220      1230      1240      1250      1260      1270      

          1190      1200      1210      1220      1230      1240   
pF1KF0 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       1280      1290      1300      1310      1320      1330      

          1250      1260      1270      1280      1290      1300   
pF1KF0 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIW
       1340      1350      1360      1370      1380      1390      

          1310         
pF1KF0 MDVIVTGAEGYTQFMN
       :               
XP_005 MDVIVTGAEGYTQFMN
       1400      1410  

>>XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin homo  (1423 aa)
 initn: 6290 init1: 5987 opt: 5996  Z-score: 2504.7  bits: 475.9 E(85289): 9e-133
Smith-Waterman score: 8353; 95.7% identity (95.7% similar) in 1351 aa overlap (1-1293:47-1397)

                                             10        20        30
pF1KF0                               MDALNRNQIGPGCQTQTMVQKGPLDLIETG
                                     ::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
         20        30        40        50        60        70      

               40        50        60        70        80        90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
         80        90       100       110       120       130      

              100       110       120       130       140       150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
        140       150       160       170       180       190      

              160       170       180       190       200       210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
        200       210       220       230       240       250      

              220       230       240       250       260       270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
        260       270       280       290       300       310      

              280       290       300       310       320       330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
        320       330       340       350       360       370      

              340       350       360       370       380       390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
        380       390       400       410       420       430      

              400       410       420       430       440       450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
        440       450       460       470       480       490      

              460       470       480       490       500       510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
        500       510       520       530       540       550      

              520       530       540       550       560       570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
        560       570       580       590       600       610      

              580       590       600       610       620       630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
        620       630       640       650       660       670      

              640       650       660       670       680       690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
        680       690       700       710       720       730      

              700       710       720       730       740       750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
        740       750       760       770       780       790      

              760       770       780       790       800       810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
        800       810       820       830       840       850      

              820       830       840       850       860       870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
        860       870       880       890       900       910      

              880       890       900       910                    
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
        920       930       940       950       960       970      

                                         920       930       940   
pF1KF0 -----------------------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
                                    :::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
        980       990      1000      1010      1020      1030      

           950       960       970       980       990      1000   
pF1KF0 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
       1040      1050      1060      1070      1080      1090      

          1010      1020      1030      1040      1050      1060   
pF1KF0 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
       1100      1110      1120      1130      1140      1150      

          1070      1080      1090      1100      1110      1120   
pF1KF0 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
       1160      1170      1180      1190      1200      1210      

          1130      1140      1150      1160      1170      1180   
pF1KF0 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
       1220      1230      1240      1250      1260      1270      

          1190      1200      1210      1220      1230      1240   
pF1KF0 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
       1280      1290      1300      1310      1320      1330      

          1250      1260      1270                 1280      1290  
pF1KF0 VDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYM
       ::::::::::::::::::::::::::::::           :::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
       1340      1350      1360      1370      1380      1390      

           1300      1310         
pF1KF0 VAPSAEAMRIWMDVIVTGAEGYTQFMN
       :                          
XP_005 VAPSAEAMRIWMDVIVTGAEGYTQFMN
       1400      1410      1420   




1319 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 06:35:42 2016 done: Sat Nov  5 06:35:45 2016
 Total Scan time: 21.090 Total Display time:  0.690

Function used was FASTA [36.3.4 Apr, 2011]
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