Result of FASTA (omim) for pF1KB7325
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7325, 1649 aa
  1>>>pF1KB7325 1649 - 1649 aa - 1649 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.1836+/-0.000627; mu= -11.2101+/- 0.039
 mean_var=821.2858+/-183.127, 0's: 0 Z-trim(117.6): 62  B-trim: 0 in 0/53
 Lambda= 0.044754
 statistics sampled from 29661 (29710) to 29661 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.348), width:  16
 Scan time: 19.300

The best scores are:                                      opt bits E(85289)
NP_001013725 (OMIM: 234810,609280) eIF-2-alpha kin (1649) 10902 722.0  1e-206
XP_005254449 (OMIM: 234810,609280) PREDICTED: eIF- (1626) 10316 684.2 2.5e-195
XP_011519901 (OMIM: 234810,609280) PREDICTED: eIF- (1611) 10303 683.4 4.4e-195
XP_016877708 (OMIM: 234810,609280) PREDICTED: eIF- (1554) 8405 560.8 3.4e-158
XP_011519902 (OMIM: 234810,609280) PREDICTED: eIF- (1592) 8405 560.8 3.4e-158
NP_001276023 (OMIM: 142810,614504,616625) histidin ( 480)  525 51.3 2.4e-05
NP_002100 (OMIM: 142810,614504,616625) histidine-- ( 509)  525 51.3 2.5e-05
NP_001244969 (OMIM: 142810,614504,616625) histidin ( 469)  454 46.7 0.00057
NP_036340 (OMIM: 600783,614926) probable histidine ( 506)  445 46.2 0.00089
XP_016864778 (OMIM: 600783,614926) PREDICTED: prob ( 436)  443 46.0 0.00089
XP_016864777 (OMIM: 600783,614926) PREDICTED: prob ( 436)  443 46.0 0.00089
XP_011535921 (OMIM: 600783,614926) PREDICTED: prob ( 512)  445 46.2  0.0009
NP_001265660 (OMIM: 600783,614926) probable histid ( 481)  443 46.0 0.00095


>>NP_001013725 (OMIM: 234810,609280) eIF-2-alpha kinase   (1649 aa)
 initn: 10902 init1: 10902 opt: 10902  Z-score: 3832.2  bits: 722.0 E(85289): 1e-206
Smith-Waterman score: 10902; 100.0% identity (100.0% similar) in 1649 aa overlap (1-1649:1-1649)

               10        20        30        40        50        60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
             1570      1580      1590      1600      1610      1620

             1630      1640         
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
       :::::::::::::::::::::::::::::
NP_001 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
             1630      1640         

>>XP_005254449 (OMIM: 234810,609280) PREDICTED: eIF-2-al  (1626 aa)
 initn: 10301 init1: 10301 opt: 10316  Z-score: 3627.8  bits: 684.2 E(85289): 2.5e-195
Smith-Waterman score: 10713; 98.6% identity (98.6% similar) in 1649 aa overlap (1-1649:1-1626)

               10        20        30        40        50        60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
XP_005 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQV------
             1510      1520      1530      1540      1550          

             1570      1580      1590      1600      1610      1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
                        :::::::::::::::::::::::::::::::::::::::::::
XP_005 -----------------DLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
                          1560      1570      1580      1590       

             1630      1640         
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
       :::::::::::::::::::::::::::::
XP_005 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
      1600      1610      1620      

>>XP_011519901 (OMIM: 234810,609280) PREDICTED: eIF-2-al  (1611 aa)
 initn: 10296 init1: 10296 opt: 10303  Z-score: 3623.3  bits: 683.4 E(85289): 4.4e-195
Smith-Waterman score: 10592; 97.7% identity (97.7% similar) in 1649 aa overlap (1-1649:1-1611)

               10        20        30        40        50        60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
XP_011 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQ-------
             1510      1520      1530      1540      1550          

             1570      1580      1590      1600      1610      1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
                                      :::::::::::::::::::::::::::::
XP_011 -------------------------------WDADEQAFNTTVKQLLSRLPKQRYLKLVC
                                         1560      1570      1580  

             1630      1640         
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
       :::::::::::::::::::::::::::::
XP_011 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
           1590      1600      1610 

>>XP_016877708 (OMIM: 234810,609280) PREDICTED: eIF-2-al  (1554 aa)
 initn: 8771 init1: 8401 opt: 8405  Z-score: 2961.2  bits: 560.8 E(85289): 3.4e-158
Smith-Waterman score: 10109; 94.2% identity (94.2% similar) in 1649 aa overlap (1-1649:1-1554)

               10        20        30        40        50        60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
XP_016 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNS-------
             1210      1220      1230      1240      1250          

             1270      1280      1290      1300      1310      1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
                                                         ::::::::::
XP_016 --------------------------------------------------VLINLGLVYK
                                                            1260   

             1330      1340      1350      1360      1370      1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
          1270      1280      1290      1300      1310      1320   

             1390      1400      1410      1420      1430      1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
          1330      1340      1350      1360      1370      1380   

             1450      1460      1470      1480      1490      1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
          1390      1400      1410      1420      1430      1440   

             1510      1520      1530      1540      1550      1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
XP_016 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQ-------
          1450      1460      1470      1480      1490             

             1570      1580      1590      1600      1610      1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
                                      :::::::::::::::::::::::::::::
XP_016 -------------------------------WDADEQAFNTTVKQLLSRLPKQRYLKLVC
                                      1500      1510      1520     

             1630      1640         
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
       :::::::::::::::::::::::::::::
XP_016 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
        1530      1540      1550    

>>XP_011519902 (OMIM: 234810,609280) PREDICTED: eIF-2-al  (1592 aa)
 initn: 8401 init1: 8401 opt: 8405  Z-score: 2961.1  bits: 560.8 E(85289): 3.4e-158
Smith-Waterman score: 10419; 96.5% identity (96.5% similar) in 1649 aa overlap (1-1649:1-1592)

               10        20        30        40        50        60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
XP_011 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNS-------
             1210      1220      1230      1240      1250          

             1270      1280      1290      1300      1310      1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
                                                         ::::::::::
XP_011 --------------------------------------------------VLINLGLVYK
                                                            1260   

             1330      1340      1350      1360      1370      1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
          1270      1280      1290      1300      1310      1320   

             1390      1400      1410      1420      1430      1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
          1330      1340      1350      1360      1370      1380   

             1450      1460      1470      1480      1490      1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
          1390      1400      1410      1420      1430      1440   

             1510      1520      1530      1540      1550      1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
          1450      1460      1470      1480      1490      1500   

             1570      1580      1590      1600      1610      1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
          1510      1520      1530      1540      1550      1560   

             1630      1640         
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
       :::::::::::::::::::::::::::::
XP_011 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
          1570      1580      1590  

>>NP_001276023 (OMIM: 142810,614504,616625) histidine--t  (480 aa)
 initn: 363 init1: 139 opt: 525  Z-score: 216.9  bits: 51.3 E(85289): 2.4e-05
Smith-Waterman score: 525; 26.4% identity (63.4% similar) in 454 aa overlap (1055-1489:35-472)

         1030      1040      1050      1060      1070      1080    
pF1KB7 KAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLC
                                     ..: :   ....: ..::: ::::::  . 
NP_001 EVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVID
           10        20        30        40        50        60    

         1090      1100          1110      1120      1130      1140
pF1KB7 TPLLLPRNRQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::..  ..  . ...: . ..    :..: :. : .:: .:::::.: :.. :.::: : 
NP_001 TPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIA
           70        80        90       100       110       120    

               1150      1160      1170      1180      1190        
pF1KB7 RVFRPRK--LDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSI
       .:.:  .  . : . .:. .: :::. .. . ..: :: .  . ::..   .::  .. .
NP_001 KVYRRDNPAMTRGRYREFYQCDFDIA-GNFDPMIPDAECLKIMCEILS---SLQIGDFLV
          130       140       150        160       170          180

     1200      1210      1220      1230      1240       1250       
pF1KB7 YLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLS-LSSNSLCRL
        .:   .: ...  ::. ..:.  .   . : . .:.. .::. .. . . :. .   :.
NP_001 KVNDRRILDGMFAICGVSDSKFRTICSSV-DKL-DKVSWEEVKNEMVGEKGLAPEVADRI
              190       200        210        220       230        

      1260      1270      1280       1290      1300      1310      
pF1KB7 YKFIEQKGDLQDLMPTINSLIKQ-KTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLG
         ...:.: ..     ...:... : .  . .  :: ::. .   :  .::  .. ..:.
NP_001 GDYVQQHGGVS----LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLS
      240           250       260       270       280       290    

       1320      1330      1340           1350      1360      1370 
pF1KB7 LVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALGPVPTA
       :.  .. ..:.:.. : ...   .:  : :     ::::::: :. .:  :..   ::  
NP_001 LARGLDYYTGVIYEAV-LLQTPAQAGEEPLGVGSVAAGGRYDGLVGMF-DPKGR-KVPC-
          300       310        320       330       340         350 

            1380          1390      1400      1410      1420       
pF1KB7 IGVSIAIDKISAAVLN----MEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAE
       .:.::....: . : .    .::..  .  ..::.:. .  . . ..:...:: ::: ::
NP_001 VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAE
              360       370       380       390       400       410

      1430      1440      1450      1460        1470      1480     
pF1KB7 IMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFEKERQTEKRVLETELVDH
       ..:  . .  .  .::..  :  ::.....: .   .:..:  ...... :  . .::..
NP_001 LLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR--REDLVEE
              420       430       440       450       460          

        1490      1500      1510      1520      1530      1540     
pF1KB7 VLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSAS
       . ..                                                        
NP_001 IKRRTGQPLCIC                                                
      470       480                                                

>>NP_002100 (OMIM: 142810,614504,616625) histidine--tRNA  (509 aa)
 initn: 363 init1: 139 opt: 525  Z-score: 216.7  bits: 51.3 E(85289): 2.5e-05
Smith-Waterman score: 525; 26.4% identity (63.4% similar) in 454 aa overlap (1055-1489:64-501)

         1030      1040      1050      1060      1070      1080    
pF1KB7 KAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLC
                                     ..: :   ....: ..::: ::::::  . 
NP_002 EVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVID
            40        50        60        70        80        90   

         1090      1100          1110      1120      1130      1140
pF1KB7 TPLLLPRNRQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
       ::..  ..  . ...: . ..    :..: :. : .:: .:::::.: :.. :.::: : 
NP_002 TPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIA
           100       110       120       130       140       150   

               1150      1160      1170      1180      1190        
pF1KB7 RVFRPRK--LDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSI
       .:.:  .  . : . .:. .: :::. .. . ..: :: .  . ::..   .::  .. .
NP_002 KVYRRDNPAMTRGRYREFYQCDFDIA-GNFDPMIPDAECLKIMCEILS---SLQIGDFLV
           160       170        180       190       200            

     1200      1210      1220      1230      1240       1250       
pF1KB7 YLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLS-LSSNSLCRL
        .:   .: ...  ::. ..:.  .   . : . .:.. .::. .. . . :. .   :.
NP_002 KVNDRRILDGMFAICGVSDSKFRTICSSV-DKL-DKVSWEEVKNEMVGEKGLAPEVADRI
     210       220       230        240        250       260       

      1260      1270      1280       1290      1300      1310      
pF1KB7 YKFIEQKGDLQDLMPTINSLIKQ-KTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLG
         ...:.: ..     ...:... : .  . .  :: ::. .   :  .::  .. ..:.
NP_002 GDYVQQHGGVS----LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLS
       270           280       290       300       310       320   

       1320      1330      1340           1350      1360      1370 
pF1KB7 LVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALGPVPTA
       :.  .. ..:.:.. : ...   .:  : :     ::::::: :. .:  :..   ::  
NP_002 LARGLDYYTGVIYEAV-LLQTPAQAGEEPLGVGSVAAGGRYDGLVGMF-DPKGR-KVPC-
           330        340       350       360       370            

            1380          1390      1400      1410      1420       
pF1KB7 IGVSIAIDKISAAVLN----MEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAE
       .:.::....: . : .    .::..  .  ..::.:. .  . . ..:...:: ::: ::
NP_002 VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAE
     380       390       400       410       420       430         

      1430      1440      1450      1460        1470      1480     
pF1KB7 IMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFEKERQTEKRVLETELVDH
       ..:  . .  .  .::..  :  ::.....: .   .:..:  ...... :  . .::..
NP_002 LLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR--REDLVEE
     440       450       460       470       480       490         

        1490      1500      1510      1520      1530      1540     
pF1KB7 VLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSAS
       . ..                                                        
NP_002 IKRRTGQPLCIC                                                
       500                                                         

>>NP_001244969 (OMIM: 142810,614504,616625) histidine--t  (469 aa)
 initn: 312 init1: 141 opt: 454  Z-score: 192.3  bits: 46.7 E(85289): 0.00057
Smith-Waterman score: 454; 26.3% identity (63.4% similar) in 399 aa overlap (1106-1489:79-461)

        1080      1090      1100      1110      1120      1130     
pF1KB7 KRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLK
                                     :..: :. : .:: .:::::.: :.. :.:
NP_001 ESKQKFVLKTPKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIK
       50        60        70        80        90       100        

        1140        1150      1160      1170      1180      1190   
pF1KB7 RYCIERVFRPRK--LDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQE
       :: : .:.:  .  . : . .:. .: :::. .. . ..: :: .  . ::..   .:: 
NP_001 RYHIAKVYRRDNPAMTRGRYREFYQCDFDIA-GNFDPMIPDAECLKIMCEILS---SLQI
      110       120       130        140       150       160       

          1200      1210      1220      1230      1240       1250  
pF1KB7 RNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLS-LSSN
        .. . .:   .: ...  ::. ..:.  .   . : . .:.. .::. .. . . :. .
NP_001 GDFLVKVNDRRILDGMFAICGVSDSKFRTICSSV-DKL-DKVSWEEVKNEMVGEKGLAPE
          170       180       190        200        210       220  

           1260      1270      1280       1290      1300      1310 
pF1KB7 SLCRLYKFIEQKGDLQDLMPTINSLIKQ-KTGIAQLVKYGLKDLEEVVGLLKKLGIKLQV
          :.  ...:.: ..     ...:... : .  . .  :: ::. .   :  .::  ..
NP_001 VADRIGDYVQQHGGVS----LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKI
            230           240       250       260       270        

            1320      1330      1340           1350      1360      
pF1KB7 LINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALG
        ..:.:.  .. ..:.:.. : ...   .:  : :     ::::::: :. .:  :..  
NP_001 SFDLSLARGLDYYTGVIYEAV-LLQTPAQAGEEPLGVGSVAAGGRYDGLVGMF-DPKGR-
      280       290        300       310       320       330       

       1370      1380          1390      1400      1410      1420  
pF1KB7 PVPTAIGVSIAIDKISAAVLN----MEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTA
        ::  .:.::....: . : .    .::..  .  ..::.:. .  . . ..:...:: :
NP_001 KVPC-VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDA
          340       350       360       370       380       390    

           1430      1440      1450      1460        1470      1480
pF1KB7 GITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFEKERQTEKRVLET
       :: ::..:  . .  .  .::..  :  ::.....: .   .:..:  ...... :  . 
NP_001 GIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR--RE
          400       410       420       430       440       450    

             1490      1500      1510      1520      1530      1540
pF1KB7 ELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPE
       .::... ..                                                   
NP_001 DLVEEIKRRTGQPLCIC                                           
            460                                                    

>>NP_036340 (OMIM: 600783,614926) probable histidine--tR  (506 aa)
 initn: 309 init1: 104 opt: 445  Z-score: 188.8  bits: 46.2 E(85289): 0.00089
Smith-Waterman score: 445; 26.7% identity (59.3% similar) in 450 aa overlap (1053-1476:61-492)

           1030      1040      1050      1060        1070      1080
pF1KB7 DGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKM--QQHVCETIIRIFKRHGA
                                     ::. ..   .:  .... . .:  ::::::
NP_036 VRCQSQVAEAVLTSQLKAHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGA
               40        50        60        70        80        90

             1090      1100          1110      1120      1130      
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKR
         . :: .  ..    ...: . .:    :..: :. : .:: .:::::.: :.. ..::
NP_036 KGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKR
              100       110       120       130       140       150

       1140          1150      1160      1170      1180      1190  
pF1KB7 YCIERVFR---PRKLD-RFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQ
       : . .:.:   :  .. :.  .:. .: :::. .  . ..: :: .  . ::..   .::
NP_036 YHVGKVWRRESPTIVQGRY--REFCQCDFDIA-GQFDPMIPDAECLKIMCEILS---GLQ
              160         170       180        190       200       

           1200      1210      1220        1230      1240      1250
pF1KB7 ERNYSIYLNHTMLLKAILLHCGIPEDKLSQV--YIILYDAVTEKLTRREVEAKFCNLSLS
         .. : .:   .. ...  ::.::.:.  .   :   : .. : .:.:. .:    .:.
NP_036 LGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVK---KGLA
          210       220       230       240       250          260 

             1260        1270      1280      1290      1300        
pF1KB7 SNSLCRLYKFIEQKG--DLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIK
        .   :.  ... .:  .: . :     : ..: ..      :: ::. .   :  .:: 
NP_036 PEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALE-----GLGDLKLLFEYLTLFGIA
             270       280       290            300       310      

     1310      1320      1330      1340           1350      1360   
pF1KB7 LQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQ
        .. ..:.:.  .. ..:.:.. : ...   .:  : :     ::::::: :. .:  :.
NP_036 DKISFDLSLARGLDYYTGVIYEAV-LLQTPTQAGEEPLNVGSVAAGGRYDGLVGMF-DPK
        320       330       340        350       360       370     

          1370      1380          1390      1400      1410         
pF1KB7 ALGPVPTAIGVSIAIDKISAAVLN-ME---ESVTISSCDLLVVSVGQMSMSRAINLTQKL
       .   ::  .:.::....:   : . :.   :.:  .  ...:..  .  ... ..:  .:
NP_036 G-HKVPC-VGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAEL
           380        390       400       410       420       430  

    1420      1430      1440      1450      1460         1470      
pF1KB7 WTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFE-KERQTEKR
       : .:: ::..:  . .     .::.   :  :......: ..  .:..:   .:. . ::
NP_036 WDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKR
            440       450       460       470       480       490  

       1480      1490      1500      1510      1520      1530      
pF1KB7 VLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSV
                                                                   
NP_036 ENFVAEIQKRLSES                                              
            500                                                    

>>XP_016864778 (OMIM: 600783,614926) PREDICTED: probable  (436 aa)
 initn: 309 init1: 104 opt: 443  Z-score: 188.8  bits: 46.0 E(85289): 0.00089
Smith-Waterman score: 443; 26.7% identity (59.6% similar) in 438 aa overlap (1063-1476:3-422)

           1040      1050      1060      1070      1080      1090  
pF1KB7 QIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRN
                                     ..... . .:  ::::::  . :: .  ..
XP_016                             MVVREKILDLVISCFKRHGAKGMDTPAFELKE
                                           10        20        30  

           1100          1110      1120      1130      1140        
pF1KB7 RQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFR---P
           ...: . .:    :..: :. : .:: .:::::.: :.. ..::: . .:.:   :
XP_016 TLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESP
             40        50        60        70        80        90  

         1150      1160      1170      1180      1190      1200    
pF1KB7 RKLD-RFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTM
         .. :.  .:. .: :::. .  . ..: :: .  . ::..   .::  .. : .:   
XP_016 TIVQGRY--REFCQCDFDIA-GQFDPMIPDAECLKIMCEILS---GLQLGDFLIKVNDRR
              100       110        120       130          140      

         1210      1220        1230      1240      1250      1260  
pF1KB7 LLKAILLHCGIPEDKLSQV--YIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIE
       .. ...  ::.::.:.  .   :   : .. : .:.:. .:    .:. .   :.  ...
XP_016 IVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVK---KGLAPEVADRIGDYVQ
        150       160       170       180          190       200   

             1270      1280      1290      1300      1310      1320
pF1KB7 QKG--DLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
        .:  .: . :     : ..: ..      :: ::. .   :  .::  .. ..:.:.  
XP_016 CHGGVSLVEQMFQDPRLSQNKQALE-----GLGDLKLLFEYLTLFGIADKISFDLSLARG
           210       220            230       240       250        

             1330      1340           1350      1360      1370     
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALGPVPTAIGVS
       .. ..:.:.. : ...   .:  : :     ::::::: :. .:  :..   ::  .:.:
XP_016 LDYYTGVIYEAV-LLQTPTQAGEEPLNVGSVAAGGRYDGLVGMF-DPKG-HKVPC-VGLS
      260       270        280       290       300         310     

        1380          1390      1400      1410      1420      1430 
pF1KB7 IAIDKISAAVLN-ME---ESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYD
       :....:   : . :.   :.:  .  ...:..  .  ... ..:  .:: .:: ::..: 
XP_016 IGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYK
          320       330       340       350       360       370    

            1440      1450      1460         1470      1480        
pF1KB7 WSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFE-KERQTEKRVLETELVDHVLQ
        . .     .::.   :  :......: ..  .:..:   .:. . ::            
XP_016 NNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLS
          380       390       400       410       420       430    

     1490      1500      1510      1520      1530      1540        
pF1KB7 KLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRR
                                                                   
XP_016 ES                                                          
                                                                   




1649 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 02:43:02 2016 done: Sat Nov  5 02:43:05 2016
 Total Scan time: 19.300 Total Display time:  0.750

Function used was FASTA [36.3.4 Apr, 2011]
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