Result of FASTA (omim) for pF1KB8011
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8011, 414 aa
  1>>>pF1KB8011     414 - 414 aa - 414 aa
Library: /omim/omim.rfq.tfa
  64092750 residues in 91774 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.7832+/-0.000411; mu= 14.2750+/- 0.025
 mean_var=89.0931+/-17.689, 0's: 0 Z-trim(113.1): 269  B-trim: 399 in 1/51
 Lambda= 0.135879
 statistics sampled from 22738 (23103) to 22738 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.252), width:  16
 Scan time:  3.960

The best scores are:                                      opt bits E(91774)
NP_057457 (OMIM: 133239,605131,614322,616211) WW d ( 414) 2794 558.3 1.4e-158
NP_001278926 (OMIM: 133239,605131,614322,616211) W ( 301) 2001 402.7 6.6e-112
NP_570607 (OMIM: 133239,605131,614322,616211) WW d ( 189) 1171 239.9 4.4e-63
NP_057110 (OMIM: 607849,616108) retinol dehydrogen ( 318)  539 116.2 1.3e-25
NP_689656 (OMIM: 608830,612712) retinol dehydrogen ( 316)  538 116.0 1.5e-25
NP_653284 (OMIM: 616157) dehydrogenase/reductase S ( 377)  518 112.1 2.6e-24
NP_065956 (OMIM: 616796) retinol dehydrogenase 14  ( 336)  517 111.9 2.7e-24
NP_001239579 (OMIM: 607849,616108) retinol dehydro ( 248)  299 69.0 1.6e-11
NP_001257353 (OMIM: 616163) dehydrogenase/reductas ( 317)  275 64.4 4.9e-10
XP_005260627 (OMIM: 606409,613385) E3 ubiquitin-pr ( 692)  257 61.1 1.1e-08
XP_011527381 (OMIM: 606409,613385) E3 ubiquitin-pr ( 692)  257 61.1 1.1e-08
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752)  257 61.1 1.1e-08
XP_016883580 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752)  257 61.1 1.1e-08
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862)  257 61.2 1.2e-08
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862)  257 61.2 1.2e-08
XP_016883579 (OMIM: 606409,613385) E3 ubiquitin-pr ( 900)  257 61.2 1.3e-08
XP_016883578 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903)  257 61.2 1.3e-08
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903)  257 61.2 1.3e-08
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903)  257 61.2 1.3e-08
XP_024307773 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903)  257 61.2 1.3e-08
XP_016868486 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 719)  229 55.6 4.9e-07
XP_016868484 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 743)  229 55.7   5e-07
XP_016868485 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 743)  229 55.7   5e-07
XP_024302824 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 898)  229 55.7 5.8e-07
XP_016868483 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 898)  229 55.7 5.8e-07
XP_016868482 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 921)  229 55.7 5.9e-07
XP_005250818 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 921)  229 55.7 5.9e-07
NP_008944 (OMIM: 602307) NEDD4-like E3 ubiquitin-p ( 922)  229 55.7 5.9e-07
XP_005250817 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 922)  229 55.7 5.9e-07
NP_001186776 (OMIM: 605568) E3 ubiquitin-protein l ( 728)  202 50.4 1.9e-05
NP_851994 (OMIM: 605568) E3 ubiquitin-protein liga ( 731)  202 50.4 1.9e-05
NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753)  174 44.9 0.00089
XP_011519927 (OMIM: 602278) E3 ubiquitin-protein l ( 849)  174 44.9 0.00097
XP_011519928 (OMIM: 602278) E3 ubiquitin-protein l ( 849)  174 44.9 0.00097
XP_011519926 (OMIM: 602278) E3 ubiquitin-protein l ( 875)  174 44.9   0.001
NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900)  174 44.9   0.001
NP_057329 (OMIM: 612831) estradiol 17-beta-dehydro ( 300)  167 43.2  0.0011
NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247)  174 45.0  0.0013
NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302)  174 45.0  0.0014
NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303)  174 45.0  0.0014
NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319)  174 45.0  0.0014
XP_016881165 (OMIM: 606384,617201) E3 ubiquitin-pr ( 856)  171 44.3  0.0015
NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-C ( 292)  161 42.0  0.0025
NP_078981 (OMIM: 616163) dehydrogenase/reductase S ( 242)  157 41.2  0.0037
NP_001026889 (OMIM: 616163) dehydrogenase/reductas ( 271)  157 41.2   0.004
XP_011508777 (OMIM: 612131) dehydrogenase/reductas ( 319)  156 41.1  0.0052
NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319)  156 41.1  0.0052
NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319)  156 41.1  0.0052
NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319)  156 41.1  0.0052
NP_001291442 (OMIM: 606756) 3-keto-steroid reducta ( 111)  149 39.4  0.0059


>>NP_057457 (OMIM: 133239,605131,614322,616211) WW domai  (414 aa)
 initn: 2794 init1: 2794 opt: 2794  Z-score: 2968.8  bits: 558.3 E(91774): 1.4e-158
Smith-Waterman score: 2794; 99.8% identity (100.0% similar) in 414 aa overlap (1-414:1-414)

               10        20        30        40        50        60
pF1KB8 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVETM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_057 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 QLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 ILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTV
              310       320       330       340       350       360

              370       380       390       400       410    
pF1KB8 YCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
              370       380       390       400       410    

>>NP_001278926 (OMIM: 133239,605131,614322,616211) WW do  (301 aa)
 initn: 2001 init1: 2001 opt: 2001  Z-score: 2130.6  bits: 402.7 E(91774): 6.6e-112
Smith-Waterman score: 2001; 99.7% identity (100.0% similar) in 301 aa overlap (114-414:1-301)

            90       100       110       120       130       140   
pF1KB8 TYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKS
                                     ::::::::::::::::::::::::::::::
NP_001                               MEILQGRDFTGKVVVVTGANSGIGFETAKS
                                             10        20        30

           150       160       170       180       190       200   
pF1KB8 FALHGAHVILACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVP
       :::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 FALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVP
               40        50        60        70        80        90

           210       220       230       240       250       260   
pF1KB8 LHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESH
              100       110       120       130       140       150

           270       280       290       300       310       320   
pF1KB8 RFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHP
              160       170       180       190       200       210

           330       340       350       360       370       380   
pF1KB8 GNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCM
              220       230       240       250       260       270

           390       400       410    
pF1KB8 PSPEAQSEETARTLWALSERLIQERLGSQSG
       :::::::::::::::::::::::::::::::
NP_001 PSPEAQSEETARTLWALSERLIQERLGSQSG
              280       290       300 

>>NP_570607 (OMIM: 133239,605131,614322,616211) WW domai  (189 aa)
 initn: 1171 init1: 1171 opt: 1171  Z-score: 1254.1  bits: 239.9 E(91774): 4.4e-63
Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172)

               10        20        30        40        50        60
pF1KB8 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_570 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_570 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVETM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
NP_570 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWKTKYHPPP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV
                                                                   
NP_570 EKCRIKIFH                                                   
                                                                   

>>NP_057110 (OMIM: 607849,616108) retinol dehydrogenase   (318 aa)
 initn: 656 init1: 390 opt: 539  Z-score: 581.4  bits: 116.2 E(91774): 1.3e-25
Smith-Waterman score: 661; 42.4% identity (67.4% similar) in 288 aa overlap (124-405:41-313)

           100       110       120       130       140       150   
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
                                     ::::::::::.::: :::: .: .::.: :
NP_057 LLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYL
               20        30        40        50        60        70

           160       170       180       190       200       210   
pF1KB8 ACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
       :::.. ..  ....:     . .: .  :::.  .:.. ::..: :..  ::::. ::..
NP_057 ACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGV
               80        90       100       110       120       130

           220       230       240       250       260       270   
pF1KB8 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
       .  :.: : ::.:  . ::::::: :..:: . : .:::.:.. ::: .:.       ::
NP_057 MMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHH-------LG
              140       150       160       170       180          

           280       290       300       310       320       330   
pF1KB8 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
       .. :  :.  :  : : ::: .::: ::::..:: :::.  :::. .::::...   ...
NP_057 RIHFHNLQGEKF-YNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH
           190        200       210       220       230       240  

                 340       350       360       370       380       
pF1KB8 S------WWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPE
       :      ::....       : :. :::: :...:: .  :: :.: .:..:     : .
NP_057 SSFMRWMWWLFSF-------FIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQ
            250              260       270       280       290     

       390       400       410    
pF1KB8 AQSEETARTLWALSERLIQERLGSQSG
       :..:  :: :: .:  :.         
NP_057 ARNETIARRLWDVSCDLLGLPID    
         300       310            

>>NP_689656 (OMIM: 608830,612712) retinol dehydrogenase   (316 aa)
 initn: 694 init1: 408 opt: 538  Z-score: 580.3  bits: 116.0 E(91774): 1.5e-25
Smith-Waterman score: 712; 41.6% identity (68.8% similar) in 308 aa overlap (101-408:20-314)

               80        90       100       110       120       130
pF1KB8 GQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVT
                                     :. :. . :..   ..    .. :::::.:
NP_689            MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNV----QLPGKVVVIT
                          10        20        30            40     

              140       150       160       170       180       190
pF1KB8 GANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSV
       :::.::: :::. .: .::.: .:::.. ..  :.:.:  . ....: .  :::.  .:.
NP_689 GANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSI
          50        60        70        80        90       100     

              200       210       220       230       240       250
pF1KB8 QHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRS
       . :::.: :..  ::.:. ::...  :.: : ::.:: . ::::::: :. :: . :  :
NP_689 RAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVS
         110       120       130       140       150       160     

              260       270       280       290       300       310
pF1KB8 APARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRR
       :::::. ::: .:.       .::. :  :.  :  :   .:: .::: :.::. :: .:
NP_689 APARVVNVSSVAHH-------IGKIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKR
         170              180       190        200       210       

              320       330       340       350       360       370
pF1KB8 LSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEG
       :.  :::. ::::: .. :.. :   .  ::. :  ::.:. ..:: :...:: .  :: 
NP_689 LQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEP
       220       230        240       250       260       270      

              380       390       400       410    
pF1KB8 LGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
       :.: ::..: :   ::.:....::. :: .: .:.  :      
NP_689 LSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE    
        280       290       300       310          

>>NP_653284 (OMIM: 616157) dehydrogenase/reductase SDR f  (377 aa)
 initn: 563 init1: 216 opt: 518  Z-score: 558.1  bits: 112.1 E(91774): 2.6e-24
Smith-Waterman score: 547; 38.7% identity (61.7% similar) in 287 aa overlap (121-404:33-310)

              100       110       120       130       140       150
pF1KB8 AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAH
                                     .. :...::::::::::  ::  .: .::.
NP_653 ALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGAR
             10        20        30        40        50        60  

              160       170       180       190       200       210
pF1KB8 VILACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCN
       :.::::.. :.  :.  . .:  . .:  :.:::: : ::. :: :: ...  : .:. :
NP_653 VVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHN
             70        80        90       100       110       120  

              220       230       240       250       260       270
pF1KB8 AATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDIND
       :.  .   . :.....  ..:::.: : :..::   :   ::.::.::.: .:       
NP_653 AGISSC--GRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAH-------
              130       140       150       160       170          

              280        290       300       310       320         
pF1KB8 SLGKLDFSRLS-PTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPG--NMM
         :.:::.::. :. .    . ::  .:: :.::. ::  .:   :::  :.:::  :  
NP_653 CRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSE
           180       190       200       210       220       230   

       330       340       350       360       370       380       
pF1KB8 YSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPE
           :   :.  ::  ::    .. . :: : .:::    .: :.: :: ::      : 
NP_653 LFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPA
           240       250       260       270       280       290   

       390       400       410                                     
pF1KB8 AQSEETARTLWALSERLIQERLGSQSG                                 
       :.....:. ::  :.::                                           
NP_653 ARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSP
           300       310       320       330       340       350   

>>NP_065956 (OMIM: 616796) retinol dehydrogenase 14 [Hom  (336 aa)
 initn: 666 init1: 259 opt: 517  Z-score: 557.7  bits: 111.9 E(91774): 2.7e-24
Smith-Waterman score: 632; 40.5% identity (65.9% similar) in 299 aa overlap (124-405:43-332)

           100       110       120       130       140       150   
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
                                     ::.:..::::::.:  ::  .   ::.::.
NP_065 LGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIM
             20        30        40        50        60        70  

           160       170                    180       190       200
pF1KB8 ACRNMARASEAVSRILEEWHKA-------------KVETMTLDLALLRSVQHFAEAFKAK
       .::. ::: ::.... .: ..:             .. .  :::: ::::. : . .  .
NP_065 GCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQE
             80        90       100       110       120       130  

              210       220       230       240       250       260
pF1KB8 NVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSS
       .  : ::. ::. :  :.  :.::.:  : ::::::: :..::  .:  :::.:..::::
NP_065 EPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS
            140       150       160       170       180       190  

              270       280       290       300       310       320
pF1KB8 ESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNA
       . ... :::       :. :. ....:   . :.:::: ::::. :: :::   .:: :.
NP_065 KLYKYGDIN-------FDDLN-SEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNV
            200               210       220       230       240    

              330       340           350       360       370      
pF1KB8 VHPGNMMYSNIHRSWWVYTL---LFTLAR-PFTKSMQQGAATTVYCAAVPELEGLGGMYF
       .::: .. .:. :   .  :   ::.:.   : :.  .:: :..: :. ::.::..: ::
NP_065 LHPG-IVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYF
           250       260       270       280       290       300   

        380       390       400       410    
pF1KB8 NNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
       ..: .    :.:..: .:: :: .:: ..         
NP_065 GDCKEEELLPKAMDESVARKLWDISEVMVGLLK     
           310       320       330           

>>NP_001239579 (OMIM: 607849,616108) retinol dehydrogena  (248 aa)
 initn: 482 init1: 299 opt: 299  Z-score: 328.6  bits: 69.0 E(91774): 1.6e-11
Smith-Waterman score: 326; 29.9% identity (49.3% similar) in 288 aa overlap (124-405:41-243)

           100       110       120       130       140       150   
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
                                     ::::::::::.::: :::: .: .::.: :
NP_001 LLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYL
               20        30        40        50        60        70

           160       170       180       190       200       210   
pF1KB8 ACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
       :::.. ..  ....:     . .: .  :::.  .:.. ::..: :..  ::::. ::..
NP_001 ACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGV
               80        90       100       110       120       130

           220       230       240       250       260       270   
pF1KB8 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
       .  :.: : ::.:  . :::::                                      
NP_001 MMCPYSKTADGFEMHIGVNHLGS-------------------------------------
              140       150                                        

           280       290       300       310       320       330   
pF1KB8 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
                                                :::. .::::...   ...
NP_001 -----------------------------------------GVTTYSVHPGTVQSELVRH
                                                    160       170  

                 340       350       360       370       380       
pF1KB8 S------WWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPE
       :      ::....       : :. :::: :...:: .  :: :.: .:..:     : .
NP_001 SSFMRWMWWLFSF-------FIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQ
            180              190       200       210       220     

       390       400       410    
pF1KB8 AQSEETARTLWALSERLIQERLGSQSG
       :..:  :: :: .:  :.         
NP_001 ARNETIARRLWDVSCDLLGLPID    
         230       240            

>>NP_001257353 (OMIM: 616163) dehydrogenase/reductase SD  (317 aa)
 initn: 257 init1: 143 opt: 275  Z-score: 301.7  bits: 64.4 E(91774): 4.9e-10
Smith-Waterman score: 285; 32.3% identity (62.7% similar) in 201 aa overlap (124-324:40-230)

           100       110       120       130       140       150   
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
                                     :.: .:::.:::::  ::  .: .:. : :
NP_001 FAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHL
      10        20        30        40        50        60         

           160       170       180       190       200       210   
pF1KB8 ACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
       .::..: : .: ..:..:  . ..    .::.  ... .:.: :: ..  ::::. ::. 
NP_001 VCRDQAPAEDARGEIIRESGNQNIFLHIVDLSDPKQIWKFVENFKQEH-KLHVLINNAGC
      70        80        90       100       110        120        

           220       230       240       250       260       270   
pF1KB8 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
       ..    ::.:::: .: .: :: . :.  :  :: .    :::.::: .         . 
NP_001 MVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGML-------VQ
      130       140       150       160       170              180 

           280       290       300       310       320       330   
pF1KB8 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
       ::. . :.  .. . . ..: ..:  ..... :   .  : ..  ...:::         
NP_001 KLNTNDLQSERTPFDGTMVYAQNKRQQVVLT-ERWAQGHP-AIHFSSMHPGWADTPGVRQ
             190       200       210        220        230         

           340       350       360       370       380       390   
pF1KB8 SWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEET
                                                                   
NP_001 AMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQDRKPVSTHLPLATASSSP
     240       250       260       270       280       290         

>>XP_005260627 (OMIM: 606409,613385) E3 ubiquitin-protei  (692 aa)
 initn: 497 init1: 150 opt: 257  Z-score: 277.8  bits: 61.1 E(91774): 1.1e-08
Smith-Waterman score: 257; 43.5% identity (67.1% similar) in 85 aa overlap (13-97:224-307)

                                 10        20        30        40  
pF1KB8                   MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKT
                                     :    ::::::.:: ..: ::..::. . :
XP_005 SQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRIT
           200       210       220       230       240       250   

             50        60        70        80        90       100  
pF1KB8 QWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPT
       ::: :.. . .     :: :::..   .:  .::::  . :::.::: . .. ::     
XP_005 QWEDPRS-QGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIA
           260        270       280       290       300       310  

            110       120       130       140       150       160  
pF1KB8 TRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARAS
                                                                   
XP_005 YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG
            320       330       340       350       360       370  

>--
 initn: 370 init1: 143 opt: 232  Z-score: 251.4  bits: 56.2 E(91774): 3.1e-07
Smith-Waterman score: 232; 33.3% identity (64.0% similar) in 111 aa overlap (14-124:113-210)

                                10        20        30        40   
pF1KB8                  MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQ
                                     ..  ::::::.:. . : :::..:.:..: 
XP_005 NTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTT
             90       100       110       120       130       140  

            50        60        70        80        90       100   
pF1KB8 WEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT
       :..:.          :: :::...:. :....:::... ::.  : :  .: .       
XP_005 WDRPEP---------LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE-SVRNYEQWQLQ
                     150       160       170       180        190  

           110       120       130       140       150       160   
pF1KB8 RQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASE
       :.. .:   ::. .. : . :                                       
XP_005 RSQLQG---AMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHN
               200       210       220       230       240         




414 residues in 1 query   sequences
64092750 residues in 91774 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Jul 16 15:40:44 2019 done: Tue Jul 16 15:40:45 2019
 Total Scan time:  3.960 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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