Result of FASTA (omim) for pF1KB7223
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7223, 505 aa
  1>>>pF1KB7223 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4925+/-0.000443; mu= 16.8105+/- 0.027
 mean_var=73.1421+/-14.646, 0's: 0 Z-trim(111.0): 53  B-trim: 39 in 1/49
 Lambda= 0.149965
 statistics sampled from 19378 (19431) to 19378 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.597), E-opt: 0.2 (0.228), width:  16
 Scan time:  8.960

The best scores are:                                      opt bits E(85289)
NP_059115 (OMIM: 616693) acid-sensing ion channel  ( 505) 3416 749.0 7.6e-216
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 1843 408.6  2e-113
NP_001085 (OMIM: 601784) acid-sensing ion channel  ( 512)  791 181.0   7e-45
NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562)  753 172.8 2.3e-42
NP_061144 (OMIM: 606715) acid-sensing ion channel  ( 666)  675 156.0 3.1e-37
NP_001086 (OMIM: 602866) acid-sensing ion channel  ( 528)  643 149.0 3.1e-35
XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529)  635 147.3   1e-34
NP_899233 (OMIM: 601784) acid-sensing ion channel  ( 563)  613 142.5   3e-33
XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559)  578 135.0 5.6e-31
XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560)  570 133.2 1.9e-30
NP_064423 (OMIM: 602866) acid-sensing ion channel  ( 574)  542 127.2 1.3e-28
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320)  457 108.7 2.7e-23
NP_004760 (OMIM: 611741) acid-sensing ion channel  ( 531)  440 105.1 5.3e-22
NP_064718 (OMIM: 611741) acid-sensing ion channel  ( 543)  440 105.1 5.4e-22
NP_064717 (OMIM: 611741) acid-sensing ion channel  ( 549)  440 105.1 5.4e-22
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640)  304 75.7 4.4e-13
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646)  304 75.7 4.4e-13
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651)  304 75.7 4.5e-13
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659)  304 75.7 4.5e-13
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669)  299 74.7 9.7e-13
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692)  299 74.7   1e-12
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728)  299 74.7   1e-12
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623)  288 72.3 4.8e-12
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649)  287 72.1 5.7e-12
NP_878267 (OMIM: 606715) acid-sensing ion channel  ( 647)  269 68.2 8.5e-11
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638)  259 66.0 3.8e-10
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638)  259 66.0 3.8e-10
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696)  259 66.0   4e-10
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704)  259 66.0 4.1e-10
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732)  259 66.0 4.2e-10
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736)  259 66.0 4.2e-10
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749)  259 66.0 4.3e-10
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757)  259 66.0 4.3e-10
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760)  259 66.0 4.3e-10
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764)  259 66.0 4.4e-10
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795)  259 66.0 4.5e-10
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802)  259 66.0 4.5e-10
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810)  259 66.0 4.6e-10
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816)  259 66.1 4.6e-10
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827)  259 66.1 4.6e-10
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846)  259 66.1 4.7e-10
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851)  259 66.1 4.8e-10
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859)  259 66.1 4.8e-10
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895)  259 66.1   5e-10
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895)  259 66.1   5e-10


>>NP_059115 (OMIM: 616693) acid-sensing ion channel 5 [H  (505 aa)
 initn: 3416 init1: 3416 opt: 3416  Z-score: 3996.1  bits: 749.0 E(85289): 7.6e-216
Smith-Waterman score: 3416; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)

               10        20        30        40        50        60
pF1KB7 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
              430       440       450       460       470       480

              490       500     
pF1KB7 KISEMTQWTPPPQNHLGNKNRIEEC
       :::::::::::::::::::::::::
NP_059 KISEMTQWTPPPQNHLGNKNRIEEC
              490       500     

>>XP_016863780 (OMIM: 616693) PREDICTED: acid-sensing io  (463 aa)
 initn: 1843 init1: 1843 opt: 1843  Z-score: 2157.4  bits: 408.6 E(85289): 2e-113
Smith-Waterman score: 3041; 91.7% identity (91.7% similar) in 505 aa overlap (1-505:1-463)

               10        20        30        40        50        60
pF1KB7 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
       :::::::::::::::                                          :::
XP_016 TLLDCEFFGKPCSPK------------------------------------------EAF
              190                                                  

              250       260       270       280       290       300
pF1KB7 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
      200       210       220       230       240       250        

              310       320       330       340       350       360
pF1KB7 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
      260       270       280       290       300       310        

              370       380       390       400       410       420
pF1KB7 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
      320       330       340       350       360       370        

              430       440       450       460       470       480
pF1KB7 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
      380       390       400       410       420       430        

              490       500     
pF1KB7 KISEMTQWTPPPQNHLGNKNRIEEC
       :::::::::::::::::::::::::
XP_016 KISEMTQWTPPPQNHLGNKNRIEEC
      440       450       460   

>>NP_001085 (OMIM: 601784) acid-sensing ion channel 2 is  (512 aa)
 initn: 639 init1: 264 opt: 791  Z-score: 926.7  bits: 181.0 E(85289): 7e-45
Smith-Waterman score: 791; 32.1% identity (63.9% similar) in 446 aa overlap (41-468:20-455)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
                                     :: ....::: : .: .   :::::: :. 
NP_001            MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAF
                          10        20        30        40         

      70        80        90       100       110            120    
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLN-----RFQTDAVAK
       .::..:.  .   :.  ::..  .:...   .... :::::.::::     :. :. . .
NP_001 VGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYH
      50        60        70        80        90       100         

          130         140       150       160        170       180 
pF1KB7 FGVIFFLWHIVSKVL--HLQEITANSTGSREATDFAASH-QNFSIVEFIRNKGFYLNNST
        : .. :  .  ..   :: . ..   . :. ..:   . ..::..::..  :  :..  
NP_001 AGELLALLDVNLQIPDPHLADPSV-LEALRQKANFKHYKPKQFSMLEFLHRVGHDLKD-M
     110       120       130        140       150       160        

             190       200       210          220       230        
pF1KB7 LLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGET---LQAKRKVSVSGRGLSLLFNVNQE
       .: :.: :. :. .::. :::.::.:. :: ::    : .  : . .: :: ......:.
NP_001 MLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGG-TGNGLEIMLDIQQD
       170       180       190       200       210        220      

      240       250            260       270       280       290   
pF1KB7 AFTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEY
        .   :  : ..     ::.   ::: .. : .. ::.    :... :. .. . ..   
NP_001 EYL--PIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP
          230       240       250       260       270       280    

            300       310       320       330       340       350  
pF1KB7 PWGEC-NPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVS
       ::::: . .. :. :  :: ..:  .:....: ..:.:    .:: .  :  ...  :. 
NP_001 PWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAE
          290       300       310       320       330       340    

            360       370       380       390       400       410  
pF1KB7 PVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIR
       :.:  .  ::     ..   : . :.  .:   .:. ..::. . ::: ::.:.:.::: 
NP_001 PALGLLAEKD-----SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS
          350            360       370       380       390         

            420       430       440       450       460       470  
pF1KB7 ENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFY
       ::.. ..: .  :::.  .:.::  :. ::.:.:::.::: :::..::.:...:..    
NP_001 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK
     400       410       420       430       440       450         

            480       490       500                         
pF1KB7 WICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC                    
                                                            
NP_001 EKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
     460       470       480       490       500       510  

>>NP_001243759 (OMIM: 602866) acid-sensing ion channel 1  (562 aa)
 initn: 683 init1: 250 opt: 753  Z-score: 881.7  bits: 172.8 E(85289): 2.3e-42
Smith-Waterman score: 753; 30.3% identity (62.4% similar) in 439 aa overlap (41-468:67-492)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNI-VQNRSKIRRVLWLVVV
                                     :: : ..:: ..: :..    :.::: :. 
NP_001 SESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAF
         40        50        60        70        80        90      

      70        80        90       100       110       120         
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
       . ...    :.  :.  :...: .: ..   . .. :::::.:: :  . . ..   ...
NP_001 VLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLY
        100       110       120       130       140       150      

     130       140       150       160       170       180         
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFG
       .     . .: :.:    ..        : : . :.. .:  :.. .  .. :: : . :
NP_001 L-----APMLGLDESDDPGVPLAPPGPEAFSGEPFNLHRFY-NRSCHRLEDMLLYCSYQG
             160       170       180       190        200       210

     190       200       210       220         230       240       
pF1KB7 KPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKV--SVSGRGLSLLFNVNQEAFTDNPALG
        ::.:..:. :::.::.:.::: :.  . . :.  . .: :: ......:. .   :. :
NP_001 GPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWG
              220       230       240       250       260          

       250            260       270       280       290       300  
pF1KB7 FVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP--
        .:     :::   :::  . : .: ::.    :... :. .. . ..   ::: :.   
NP_001 ETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVT
      270       280       290       300       310       320        

               310       320       330       340       350         
pF1KB7 -NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIE
        .  :. :.::: ..:  .:..... ..:.:    .:: .  :  ..:  :..:.:: . 
NP_001 MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLV
      330       340       350       360       370       380        

     360       370       380       390       400       410         
pF1KB7 FKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIE
        ::      .   : . :.  .:   .:. ..::. . :::.::.:.:..:: ::.. ..
NP_001 EKD-----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLD
      390            400       410       420       430       440   

     420       430       440       450       460       470         
pF1KB7 INYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFL
       : .  :::.  .:.::  .. ::.:.:::.::: :::..:..:...: .           
NP_001 IFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRG
           450       460       470       480       490       500   

     480       490       500                                      
pF1KB7 LKISEMTQWTPPPQNHLGNKNRIEEC                                 
                                                                  
NP_001 KCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
           510       520       530       540       550       560  

>>NP_061144 (OMIM: 606715) acid-sensing ion channel 4 is  (666 aa)
 initn: 492 init1: 276 opt: 675  Z-score: 789.4  bits: 156.0 E(85289): 3.1e-37
Smith-Waterman score: 675; 28.5% identity (60.9% similar) in 442 aa overlap (41-468:172-593)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIV-QNRSKIRRVLWLVVV
                                     :: ....::.      .   .::.:: ...
NP_061 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL
             150       160       170       180       190       200 

      70        80        90       100        110       120        
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKME-FPAVTFCNLNRFQTDAVAKFGVI
       : :..   .:      .:.: :  ....      .  :::::.::.:::. .:..     
NP_061 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSD----
             210       220       230       240       250           

      130       140       150        160       170       180       
pF1KB7 FFLWHIVSKVLHLQEITANSTGSREATDFAA-SHQNFSIVEFIRNKGFYLNNSTLLDCEF
              . ..:: ..:.    .:..   :.  . . ..:...   :  : .  : .:.:
NP_061 -------ADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLAD-MLKSCNF
              260       270       280       290       300          

       190       200       210       220       230       240       
pF1KB7 FGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFT----DN
        :. :: ..:. :.:.::.:.:::     .   ...  : :: ......:: .     ..
NP_061 SGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRET
     310       320       330       340       350       360         

           250       260       270        280       290       300  
pF1KB7 PALGFVDAGIIFVIHSPKKVPQFDGLGL-LSPVGMHARVTIRQVKTVHQEYPWGECNPNI
          .: .:::   ::: .. : .  ::. .:: :... :. .. . ..   :::.:  . 
NP_061 NETSF-EAGIRVQIHSQEEPPYIHQLGFGVSP-GFQTFVSCQEQRLTYLPQPWGNCRAES
     370        380       390       400        410       420       

                 310       320       330       340       350       
pF1KB7 KL-----QNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH
       .:     :..:.::.:.:  .:. . . ..: :    .::    :  . :. :.. .:: 
NP_061 ELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDS
       430       440       450       460       470       480       

       360       370        380       390       400       410      
pF1KB7 IEFKDLCTVGTHNSS-CPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLV
       .        : ..   ::. :.  .:   ::.  .:.. . .::..: :... :::::..
NP_061 L------GGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFL
             490       500       510       520       530       540 

        420       430       440       450       460       470      
pF1KB7 KIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICI
        ... .  :. .  .:. : ..: ::.:::::.::: :::..:..::..:..        
NP_061 VLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLK
             550       560       570       580       590       600 

        480       490       500                                    
pF1KB7 FFLLKISEMTQWTPPPQNHLGNKNRIEEC                               
                                                                   
NP_061 RVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSRGRVEGGGVSSLLPNHHHPHGPPGGLF
             610       620       630       640       650       660 

>>NP_001086 (OMIM: 602866) acid-sensing ion channel 1 is  (528 aa)
 initn: 723 init1: 250 opt: 643  Z-score: 753.5  bits: 149.0 E(85289): 3.1e-35
Smith-Waterman score: 781; 30.6% identity (63.3% similar) in 447 aa overlap (41-468:21-458)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
                                     :: :...::. : .  .: ...:.:: .  
NP_001           MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
                         10        20        30        40        50

      70        80        90       100       110       120         
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
       :::....      :.  :: .  .:...   . .. :::::.::::.:. . :.: . ..
NP_001 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
               60        70        80        90       100          

     130       140       150       160               170       180 
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
          .... . .  ::  .. ....  ..  .. ::        .. ::    :  . .  
NP_001 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
     110       120       130       140       150       160         

             190       200       210       220         230         
pF1KB7 LLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKV--SVSGRGLSLLFNVNQEA
       ::.:.: :. :: .::  :::.::.:.::: :.  . . :.  . .: :: ......:. 
NP_001 LLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDE
      170       180       190       200       210       220        

     240       250            260       270       280       290    
pF1KB7 FTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYP
       .   :. : .:     :::   :::  . : .: ::.    :... :. .. . ..   :
NP_001 YL--PVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPP
      230         240       250       260       270       280      

          300          310       320       330       340       350 
pF1KB7 WGECNP---NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCV
       :: :.    .  :. :.::: ..:  .:..... ..:.:    .:: .  :  ..:  :.
NP_001 WGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECA
        290       300       310       320       330       340      

             360       370       380       390       400       410 
pF1KB7 SPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYI
       .:.:: .  ::      .   : . :.  .:   .:. ..::. . :::.::.:.:..::
NP_001 DPALDFLVEKD-----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYI
        350            360       370       380       390       400 

             420       430       440       450       460       470 
pF1KB7 RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNF
        ::.. ..: .  :::.  .:.::  .. ::.:.:::.::: :::..:..:...: .   
NP_001 GENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVI
             410       420       430       440       450       460 

             480       490       500                               
pF1KB7 YWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC                          
                                                                   
NP_001 KHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARG
             470       480       490       500       510       520 

>>XP_011536654 (OMIM: 602866) PREDICTED: acid-sensing io  (529 aa)
 initn: 724 init1: 250 opt: 635  Z-score: 744.1  bits: 147.3 E(85289): 1e-34
Smith-Waterman score: 773; 30.8% identity (63.2% similar) in 448 aa overlap (41-468:21-459)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
                                     :: :...::. : .  .: ...:.:: .  
XP_011           MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
                         10        20        30        40        50

      70        80        90       100       110       120         
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
       :::....      :.  :: .  .:...   . .. :::::.::::.:. . :.: . ..
XP_011 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
               60        70        80        90       100          

     130       140       150       160               170       180 
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
          .... . .  ::  .. ....  ..  .. ::        .. ::    :  . .  
XP_011 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
     110       120       130       140       150       160         

             190       200       210       220         230         
pF1KB7 LLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKV--SVSGRGLSLLFNVNQEA
       ::.:.: :. :: .::  :::.::.:.::: :.  . . :.  . .: :: ......:. 
XP_011 LLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDE
      170       180       190       200       210       220        

     240       250            260       270       280        290   
pF1KB7 FTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIR-QVKTVHQEY
       .   :. : .:     :::   :::  . : .: ::.    :... :. . : . ..   
XP_011 YL--PVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRQLIYLPP
      230         240       250       260       270       280      

           300          310       320       330       340       350
pF1KB7 PWGECNP---NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSC
       ::: :.    .  :. :.::: ..:  .:..... ..:.:    .:: .  :  ..:  :
XP_011 PWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKEC
        290       300       310       320       330       340      

              360       370       380       390       400       410
pF1KB7 VSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKY
       ..:.:: .  ::      .   : . :.  .:   .:. ..::. . :::.::.:.:..:
XP_011 ADPALDFLVEKD-----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQY
        350            360       370       380       390       400 

              420       430       440       450       460       470
pF1KB7 IRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTN
       : ::.. ..: .  :::.  .:.::  .. ::.:.:::.::: :::..:..:...: .  
XP_011 IGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEV
             410       420       430       440       450       460 

              480       490       500                              
pF1KB7 FYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC                         
                                                                   
XP_011 IKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPAR
             470       480       490       500       510       520 

>>NP_899233 (OMIM: 601784) acid-sensing ion channel 2 is  (563 aa)
 initn: 611 init1: 264 opt: 613  Z-score: 718.0  bits: 142.5 E(85289): 3e-33
Smith-Waterman score: 714; 30.0% identity (61.0% similar) in 454 aa overlap (47-468:66-506)

         20        30        40        50        60             70 
pF1KB7 EKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI-----RRVLWLVVVLG
                                     .::....  .:.       ::.::...   
NP_899 GQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCT
          40        50        60        70        80        90     

               80        90       100       110       120       130
pF1KB7 SVSLV-TWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFF
       : .:. .:.   ::: ....:. : .. .. ... ::::: :: : ..   ..: : ...
NP_899 SFGLLLSWSSN-RLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSK-GDLYY
         100        110       120       130       140        150   

                           140       150           160       170   
pF1KB7 LWH-------------IVSKVLHLQEITANSTGSREATDF----AASHQNFSIVEFIRNK
         :             .::..:. .:        :. .::       : .   . :.   
NP_899 AGHWLGLLLPNRTARPLVSELLRGDE--PRRQWFRKLADFRLFLPPRHFEGISAAFMDRL
           160       170         180       190       200       210 

           180       190       200       210          220       230
pF1KB7 GFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGET---LQAKRKVSVSGRGLS
       :  :..  ::.:.. :. :.:..:. :::.::.:. :: ::    : .  : . .: :: 
NP_899 GHQLED-MLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGG-TGNGLE
              220       230       240       250       260          

              240       250            260       270       280     
pF1KB7 LLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQ
       ......:. .   :  : ..     ::.   ::: .. : .. ::.    :... :. ..
NP_899 IMLDIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQE
     270       280         290       300       310       320       

         290        300       310       320       330       340    
pF1KB7 VKTVHQEYPWGEC-NPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDL
        . ..   ::::: . .. :. :  :: ..:  .:....: ..:.:    .:: .  :  
NP_899 QRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTP
       330       340       350       360       370       380       

          350       360       370       380       390       400    
pF1KB7 QKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKL
       ...  :. :.:  .  ::     ..   : . :.  .:   .:. ..::. . ::: ::.
NP_899 EQHKECAEPALGLLAEKD-----SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKF
       390       400            410       420       430       440  

          410       420       430       440       450       460    
pF1KB7 NQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEII
       :.:.::: ::.. ..: .  :::.  .:.::  :. ::.:.:::.::: :::..::.:..
NP_899 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF
            450       460       470       480       490       500  

          470       480       490       500                        
pF1KB7 EYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC                   
       .:..                                                        
NP_899 DYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIA
            510       520       530       540       550       560  

>>XP_011536653 (OMIM: 602866) PREDICTED: acid-sensing io  (559 aa)
 initn: 721 init1: 250 opt: 578  Z-score: 677.1  bits: 135.0 E(85289): 5.6e-31
Smith-Waterman score: 714; 28.7% identity (59.4% similar) in 478 aa overlap (41-468:21-489)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
                                     :: :...::. : .  .: ...:.:: .  
XP_011           MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
                         10        20        30        40        50

      70        80        90       100       110       120         
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
       :::....      :.  :: .  .:...   . .. :::::.::::.:. . :.: . ..
XP_011 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
               60        70        80        90       100          

     130       140       150       160               170       180 
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
          .... . .  ::  .. ....  ..  .. ::        .. ::    :  . .  
XP_011 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
     110       120       130       140       150       160         

             190                                      200       210
pF1KB7 LLDCEFFGKPCSPKDFA-------------------------------HVFTEYGNCFTF
       ::.:.: :. :: .::                                .:::.::.:.::
XP_011 LLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTF
      170       180       190       200       210       220        

              220         230       240       250            260   
pF1KB7 NHGETLQAKRKV--SVSGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKV
       : :.  . . :.  . .: :: ......:. .   :. : .:     :::   :::  . 
XP_011 NSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEP
      230       240       250       260         270       280      

           270       280       290       300          310       320
pF1KB7 PQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKECK
       : .: ::.    :... :. .. . ..   ::: :.    .  :. :.::: ..:  .:.
XP_011 PFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCE
        290       300       310       320       330       340      

              330       340       350       360       370       380
pF1KB7 AQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEI
       .... ..:.:    .:: .  :  ..:  :..:.:: .  ::      .   : . :.  
XP_011 TRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNLT
        350       360       370       380            390       400 

              390       400       410       420       430       440
pF1KB7 EYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSE
       .:   .:. ..::. . :::.::.:.:..:: ::.. ..: .  :::.  .:.::  .. 
XP_011 RYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAG
             410       420       430       440       450       460 

              450       460       470       480       490       500
pF1KB7 LLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKN
       ::.:.:::.::: :::..:..:...: .                                
XP_011 LLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDD
             470       480       490       500       510       520 

>>XP_011536652 (OMIM: 602866) PREDICTED: acid-sensing io  (560 aa)
 initn: 706 init1: 250 opt: 570  Z-score: 667.7  bits: 133.2 E(85289): 1.9e-30
Smith-Waterman score: 706; 28.8% identity (59.3% similar) in 479 aa overlap (41-468:21-490)

               20        30        40        50         60         
pF1KB7 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGI-HNIVQNRSKIRRVLWLVVV
                                     :: :...::. : .  .: ...:.:: .  
XP_011           MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF
                         10        20        30        40        50

      70        80        90       100       110       120         
pF1KB7 LGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIF
       :::....      :.  :: .  .:...   . .. :::::.::::.:. . :.: . ..
XP_011 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSK-NDLY
               60        70        80        90       100          

     130       140       150       160               170       180 
pF1KB7 FLWHIVSKVLHLQEITANSTGSREATDFAASHQNF--------SIVEFIRNKGFYLNNST
          .... . .  ::  .. ....  ..  .. ::        .. ::    :  . .  
XP_011 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRD-M
     110       120       130       140       150       160         

             190                                      200       210
pF1KB7 LLDCEFFGKPCSPKDFA-------------------------------HVFTEYGNCFTF
       ::.:.: :. :: .::                                .:::.::.:.::
XP_011 LLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTF
      170       180       190       200       210       220        

              220         230       240       250            260   
pF1KB7 NHGETLQAKRKV--SVSGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKV
       : :.  . . :.  . .: :: ......:. .   :. : .:     :::   :::  . 
XP_011 NSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEP
      230       240       250       260         270       280      

           270       280        290       300          310         
pF1KB7 PQFDGLGLLSPVGMHARVTIR-QVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKEC
       : .: ::.    :... :. . : . ..   ::: :.    .  :. :.::: ..:  .:
XP_011 PFIDQLGFGVAPGFQTFVACQEQRQLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDC
        290       300       310       320       330       340      

     320       330       340       350       360       370         
pF1KB7 KAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEE
       ..... ..:.:    .:: .  :  ..:  :..:.:: .  ::      .   : . :. 
XP_011 ETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNL
        350       360       370       380            390       400 

     380       390       400       410       420       430         
pF1KB7 IEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVS
        .:   .:. ..::. . :::.::.:.:..:: ::.. ..: .  :::.  .:.::  ..
XP_011 TRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIA
             410       420       430       440       450       460 

     440       450       460       470       480       490         
pF1KB7 ELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNK
        ::.:.:::.::: :::..:..:...: .                               
XP_011 GLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLD
             470       480       490       500       510       520 




505 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 09:43:09 2016 done: Sat Nov  5 09:43:11 2016
 Total Scan time:  8.960 Total Display time:  0.090

Function used was FASTA [36.3.4 Apr, 2011]
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