Result of FASTA (omim) for pF1KB5710
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5710, 717 aa
  1>>>pF1KB5710 717 - 717 aa - 717 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.2738+/-0.000592; mu= -18.2261+/- 0.036
 mean_var=613.8010+/-129.043, 0's: 0 Z-trim(118.8): 222  B-trim: 0 in 0/56
 Lambda= 0.051768
 statistics sampled from 31854 (32077) to 31854 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.376), width:  16
 Scan time: 13.230

The best scores are:                                      opt bits E(85289)
NP_001093646 (OMIM: 607824) protein Hook homolog 2 ( 717) 4668 364.7 7.2e-100
NP_037444 (OMIM: 607824) protein Hook homolog 2 is ( 719) 4654 363.6 1.5e-99
XP_005259931 (OMIM: 607824) PREDICTED: protein Hoo ( 716) 4651 363.4 1.7e-99
XP_005259930 (OMIM: 607824) PREDICTED: protein Hoo ( 718) 4637 362.4 3.6e-99
XP_016882210 (OMIM: 607824) PREDICTED: protein Hoo ( 644) 4154 326.3 2.4e-88
XP_011526247 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_005259934 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_011526246 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_016882209 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_011526248 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_005259933 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_011526245 (OMIM: 607824) PREDICTED: protein Hoo ( 646) 4140 325.2   5e-88
XP_011526249 (OMIM: 607824) PREDICTED: protein Hoo ( 584) 3734 294.8 6.3e-79
NP_115786 (OMIM: 607825) protein Hook homolog 3 [H ( 718) 2272 185.7 5.3e-46
NP_056972 (OMIM: 607820) protein Hook homolog 1 [H ( 728) 2119 174.3 1.5e-42
XP_011539864 (OMIM: 607820) PREDICTED: protein Hoo ( 686) 1967 162.9 3.7e-39
XP_011539865 (OMIM: 607820) PREDICTED: protein Hoo ( 559) 1690 142.2 5.5e-33
XP_006710739 (OMIM: 607820) PREDICTED: protein Hoo ( 560) 1690 142.2 5.5e-33
XP_016856913 (OMIM: 607820) PREDICTED: protein Hoo ( 451) 1285 111.8   6e-24
XP_005264483 (OMIM: 260565,609736) PREDICTED: gird (1311)  402 46.4 0.00089
NP_001241872 (OMIM: 260565,609736) girdin isoform  (1796)  402 46.5  0.0011
XP_011531270 (OMIM: 260565,609736) PREDICTED: gird (1797)  402 46.5  0.0011
XP_016859970 (OMIM: 260565,609736) PREDICTED: gird (1797)  402 46.5  0.0011
NP_060554 (OMIM: 260565,609736) girdin isoform 2 [ (1843)  402 46.5  0.0011
XP_011531269 (OMIM: 260565,609736) PREDICTED: gird (1843)  402 46.5  0.0011
XP_005264478 (OMIM: 260565,609736) PREDICTED: gird (1844)  402 46.5  0.0011
NP_001129069 (OMIM: 260565,609736) girdin isoform  (1870)  402 46.5  0.0011
XP_011531267 (OMIM: 260565,609736) PREDICTED: gird (1871)  402 46.5  0.0011
XP_011531268 (OMIM: 260565,609736) PREDICTED: gird (1871)  402 46.5  0.0011
XP_016859968 (OMIM: 260565,609736) PREDICTED: gird (1972)  402 46.5  0.0012
XP_016859967 (OMIM: 260565,609736) PREDICTED: gird (1999)  402 46.5  0.0012
XP_016859966 (OMIM: 260565,609736) PREDICTED: gird (2000)  402 46.5  0.0012
XP_016859965 (OMIM: 260565,609736) PREDICTED: gird (2026)  402 46.6  0.0012
XP_005264475 (OMIM: 260565,609736) PREDICTED: gird (2027)  402 46.6  0.0012


>>NP_001093646 (OMIM: 607824) protein Hook homolog 2 iso  (717 aa)
 initn: 4668 init1: 4668 opt: 4668  Z-score: 1913.9  bits: 364.7 E(85289): 7.2e-100
Smith-Waterman score: 4668; 100.0% identity (100.0% similar) in 717 aa overlap (1-717:1-717)

               10        20        30        40        50        60
pF1KB5 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL
              610       620       630       640       650       660

              670       680       690       700       710       
pF1KB5 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
              670       680       690       700       710       

>>NP_037444 (OMIM: 607824) protein Hook homolog 2 isofor  (719 aa)
 initn: 4830 init1: 3474 opt: 4654  Z-score: 1908.2  bits: 363.6 E(85289): 1.5e-99
Smith-Waterman score: 4654; 99.7% identity (99.7% similar) in 719 aa overlap (1-717:1-719)

               10        20        30        40        50        60
pF1KB5 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
              430       440       450       460       470       480

              490       500       510       520       530          
pF1KB5 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED--SILLK
       :::::::::::::::::::::::::::::::::::::::::::::::::::::  :::::
NP_037 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK
              490       500       510       520       530       540

      540       550       560       570       580       590        
pF1KB5 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
              550       560       570       580       590       600

      600       610       620       630       640       650        
pF1KB5 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
              610       620       630       640       650       660

      660       670       680       690       700       710       
pF1KB5 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
              670       680       690       700       710         

>>XP_005259931 (OMIM: 607824) PREDICTED: protein Hook ho  (716 aa)
 initn: 3893 init1: 3724 opt: 4651  Z-score: 1907.1  bits: 363.4 E(85289): 1.7e-99
Smith-Waterman score: 4651; 99.9% identity (99.9% similar) in 717 aa overlap (1-717:1-716)

               10        20        30        40        50        60
pF1KB5 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR
       ::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_005 LEEHLQKLHEADLELQRKREYIEELEPPTDSST-RRIEELQHNLQKKDADLRAMEERYRR
              550       560       570        580       590         

              610       620       630       640       650       660
pF1KB5 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL
     600       610       620       630       640       650         

              670       680       690       700       710       
pF1KB5 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
     660       670       680       690       700       710      

>>XP_005259930 (OMIM: 607824) PREDICTED: protein Hook ho  (718 aa)
 initn: 4475 init1: 3474 opt: 4637  Z-score: 1901.4  bits: 362.4 E(85289): 3.6e-99
Smith-Waterman score: 4637; 99.6% identity (99.6% similar) in 719 aa overlap (1-717:1-718)

               10        20        30        40        50        60
pF1KB5 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
              430       440       450       460       470       480

              490       500       510       520       530          
pF1KB5 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED--SILLK
       :::::::::::::::::::::::::::::::::::::::::::::::::::::  :::::
XP_005 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK
              490       500       510       520       530       540

      540       550       560       570       580       590        
pF1KB5 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
       ::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
XP_005 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSST-RRIEELQHNLQKKDADLRAMEERY
              550       560       570        580       590         

      600       610       620       630       640       650        
pF1KB5 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
     600       610       620       630       640       650         

      660       670       680       690       700       710       
pF1KB5 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
     660       670       680       690       700       710        

>>XP_016882210 (OMIM: 607824) PREDICTED: protein Hook ho  (644 aa)
 initn: 4154 init1: 4154 opt: 4154  Z-score: 1707.0  bits: 326.3 E(85289): 2.4e-88
Smith-Waterman score: 4154; 100.0% identity (100.0% similar) in 644 aa overlap (74-717:1-644)

            50        60        70        80        90       100   
pF1KB5 IDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                     ::::::::::::::::::::::::::::::
XP_016                               MVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                             10        20        30

           110       120       130       140       150       160   
pF1KB5 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
               40        50        60        70        80        90

           170       180       190       200       210       220   
pF1KB5 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
              100       110       120       130       140       150

           230       240       250       260       270       280   
pF1KB5 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
              160       170       180       190       200       210

           290       300       310       320       330       340   
pF1KB5 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
              220       230       240       250       260       270

           350       360       370       380       390       400   
pF1KB5 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
              280       290       300       310       320       330

           410       420       430       440       450       460   
pF1KB5 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
              340       350       360       370       380       390

           470       480       490       500       510       520   
pF1KB5 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
              400       410       420       430       440       450

           530       540       550       560       570       580   
pF1KB5 LQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHN
              460       470       480       490       500       510

           590       600       610       620       630       640   
pF1KB5 LQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHL
              520       530       540       550       560       570

           650       660       670       680       690       700   
pF1KB5 EMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPL
              580       590       600       610       620       630

           710       
pF1KB5 GRLASLNLRPTDKH
       ::::::::::::::
XP_016 GRLASLNLRPTDKH
              640    

>>XP_011526247 (OMIM: 607824) PREDICTED: protein Hook ho  (646 aa)
 initn: 4316 init1: 2960 opt: 4140  Z-score: 1701.4  bits: 325.2 E(85289): 5e-88
Smith-Waterman score: 4140; 99.7% identity (99.7% similar) in 646 aa overlap (74-717:1-646)

            50        60        70        80        90       100   
pF1KB5 IDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                     ::::::::::::::::::::::::::::::
XP_011                               MVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                             10        20        30

           110       120       130       140       150       160   
pF1KB5 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
               40        50        60        70        80        90

           170       180       190       200       210       220   
pF1KB5 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
              100       110       120       130       140       150

           230       240       250       260       270       280   
pF1KB5 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
              160       170       180       190       200       210

           290       300       310       320       330       340   
pF1KB5 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
              220       230       240       250       260       270

           350       360       370       380       390       400   
pF1KB5 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
              280       290       300       310       320       330

           410       420       430       440       450       460   
pF1KB5 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
              340       350       360       370       380       390

           470       480       490       500       510       520   
pF1KB5 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
              400       410       420       430       440       450

           530         540       550       560       570       580 
pF1KB5 LQEQGGKTED--SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
              460       470       480       490       500       510

             590       600       610       620       630       640 
pF1KB5 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
              520       530       540       550       560       570

             650       660       670       680       690       700 
pF1KB5 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
              580       590       600       610       620       630

             710       
pF1KB5 PLGRLASLNLRPTDKH
       ::::::::::::::::
XP_011 PLGRLASLNLRPTDKH
              640      

>>XP_005259934 (OMIM: 607824) PREDICTED: protein Hook ho  (646 aa)
 initn: 4316 init1: 2960 opt: 4140  Z-score: 1701.4  bits: 325.2 E(85289): 5e-88
Smith-Waterman score: 4140; 99.7% identity (99.7% similar) in 646 aa overlap (74-717:1-646)

            50        60        70        80        90       100   
pF1KB5 IDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                     ::::::::::::::::::::::::::::::
XP_005                               MVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                             10        20        30

           110       120       130       140       150       160   
pF1KB5 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
               40        50        60        70        80        90

           170       180       190       200       210       220   
pF1KB5 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
              100       110       120       130       140       150

           230       240       250       260       270       280   
pF1KB5 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
              160       170       180       190       200       210

           290       300       310       320       330       340   
pF1KB5 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
              220       230       240       250       260       270

           350       360       370       380       390       400   
pF1KB5 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
              280       290       300       310       320       330

           410       420       430       440       450       460   
pF1KB5 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
              340       350       360       370       380       390

           470       480       490       500       510       520   
pF1KB5 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
              400       410       420       430       440       450

           530         540       550       560       570       580 
pF1KB5 LQEQGGKTED--SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
              460       470       480       490       500       510

             590       600       610       620       630       640 
pF1KB5 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
              520       530       540       550       560       570

             650       660       670       680       690       700 
pF1KB5 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
              580       590       600       610       620       630

             710       
pF1KB5 PLGRLASLNLRPTDKH
       ::::::::::::::::
XP_005 PLGRLASLNLRPTDKH
              640      

>>XP_011526246 (OMIM: 607824) PREDICTED: protein Hook ho  (646 aa)
 initn: 4316 init1: 2960 opt: 4140  Z-score: 1701.4  bits: 325.2 E(85289): 5e-88
Smith-Waterman score: 4140; 99.7% identity (99.7% similar) in 646 aa overlap (74-717:1-646)

            50        60        70        80        90       100   
pF1KB5 IDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                     ::::::::::::::::::::::::::::::
XP_011                               MVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                             10        20        30

           110       120       130       140       150       160   
pF1KB5 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
               40        50        60        70        80        90

           170       180       190       200       210       220   
pF1KB5 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
              100       110       120       130       140       150

           230       240       250       260       270       280   
pF1KB5 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
              160       170       180       190       200       210

           290       300       310       320       330       340   
pF1KB5 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
              220       230       240       250       260       270

           350       360       370       380       390       400   
pF1KB5 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
              280       290       300       310       320       330

           410       420       430       440       450       460   
pF1KB5 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
              340       350       360       370       380       390

           470       480       490       500       510       520   
pF1KB5 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
              400       410       420       430       440       450

           530         540       550       560       570       580 
pF1KB5 LQEQGGKTED--SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
              460       470       480       490       500       510

             590       600       610       620       630       640 
pF1KB5 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
              520       530       540       550       560       570

             650       660       670       680       690       700 
pF1KB5 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
              580       590       600       610       620       630

             710       
pF1KB5 PLGRLASLNLRPTDKH
       ::::::::::::::::
XP_011 PLGRLASLNLRPTDKH
              640      

>>XP_016882209 (OMIM: 607824) PREDICTED: protein Hook ho  (646 aa)
 initn: 4316 init1: 2960 opt: 4140  Z-score: 1701.4  bits: 325.2 E(85289): 5e-88
Smith-Waterman score: 4140; 99.7% identity (99.7% similar) in 646 aa overlap (74-717:1-646)

            50        60        70        80        90       100   
pF1KB5 IDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                     ::::::::::::::::::::::::::::::
XP_016                               MVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                             10        20        30

           110       120       130       140       150       160   
pF1KB5 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
               40        50        60        70        80        90

           170       180       190       200       210       220   
pF1KB5 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
              100       110       120       130       140       150

           230       240       250       260       270       280   
pF1KB5 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
              160       170       180       190       200       210

           290       300       310       320       330       340   
pF1KB5 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
              220       230       240       250       260       270

           350       360       370       380       390       400   
pF1KB5 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
              280       290       300       310       320       330

           410       420       430       440       450       460   
pF1KB5 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
              340       350       360       370       380       390

           470       480       490       500       510       520   
pF1KB5 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
              400       410       420       430       440       450

           530         540       550       560       570       580 
pF1KB5 LQEQGGKTED--SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
              460       470       480       490       500       510

             590       600       610       620       630       640 
pF1KB5 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
              520       530       540       550       560       570

             650       660       670       680       690       700 
pF1KB5 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
              580       590       600       610       620       630

             710       
pF1KB5 PLGRLASLNLRPTDKH
       ::::::::::::::::
XP_016 PLGRLASLNLRPTDKH
              640      

>>XP_011526248 (OMIM: 607824) PREDICTED: protein Hook ho  (646 aa)
 initn: 4316 init1: 2960 opt: 4140  Z-score: 1701.4  bits: 325.2 E(85289): 5e-88
Smith-Waterman score: 4140; 99.7% identity (99.7% similar) in 646 aa overlap (74-717:1-646)

            50        60        70        80        90       100   
pF1KB5 IDPSWFNEAWLQGISEDPGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                     ::::::::::::::::::::::::::::::
XP_011                               MVLRSLVEYSQDVLAHPVSEEHLPDVSLIG
                                             10        20        30

           110       120       130       140       150       160   
pF1KB5 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS
               40        50        60        70        80        90

           170       180       190       200       210       220   
pF1KB5 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG
              100       110       120       130       140       150

           230       240       250       260       270       280   
pF1KB5 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQAL
              160       170       180       190       200       210

           290       300       310       320       330       340   
pF1KB5 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE
              220       230       240       250       260       270

           350       360       370       380       390       400   
pF1KB5 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE
              280       290       300       310       320       330

           410       420       430       440       450       460   
pF1KB5 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR
              340       350       360       370       380       390

           470       480       490       500       510       520   
pF1KB5 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA
              400       410       420       430       440       450

           530         540       550       560       570       580 
pF1KB5 LQEQGGKTED--SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
       ::::::::::  ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQ
              460       470       480       490       500       510

             590       600       610       620       630       640 
pF1KB5 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR
              520       530       540       550       560       570

             650       660       670       680       690       700 
pF1KB5 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRG
              580       590       600       610       620       630

             710       
pF1KB5 PLGRLASLNLRPTDKH
       ::::::::::::::::
XP_011 PLGRLASLNLRPTDKH
              640      




717 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 16:09:43 2016 done: Sat Nov  5 16:09:45 2016
 Total Scan time: 13.230 Total Display time:  0.210

Function used was FASTA [36.3.4 Apr, 2011]
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