Result of FASTA (omim) for pF1KB5891
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5891, 498 aa
  1>>>pF1KB5891 498 - 498 aa - 498 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 17.3978+/-0.00053; mu= -35.2086+/- 0.033
 mean_var=1009.4299+/-206.726, 0's: 0 Z-trim(125.9): 196  B-trim: 0 in 0/61
 Lambda= 0.040368
 statistics sampled from 50417 (50674) to 50417 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.823), E-opt: 0.2 (0.594), width:  16
 Scan time: 11.660

The best scores are:                                      opt bits E(85289)
NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome  ( 498) 3525 220.6 8.6e-57
NP_001188333 (OMIM: 605875) wiskott-Aldrich syndro ( 281) 1841 122.2 1.9e-27
NP_001278894 (OMIM: 605068) wiskott-Aldrich syndro ( 499) 1690 113.7 1.3e-24
XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 1590 107.9 7.2e-23
XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 1590 107.9 7.2e-23
NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome  ( 502) 1590 107.9 7.2e-23
XP_016866929 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866933 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_011534537 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866932 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866930 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866928 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866931 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_011534535 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_001020105 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1240 87.5 1.1e-16
XP_005267264 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_011534536 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_001020107 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1240 87.5 1.1e-16
XP_005267263 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_003922 (OMIM: 605035) wiskott-Aldrich syndrome  ( 559) 1240 87.5 1.1e-16
XP_016866927 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_016866926 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_005267260 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_001020106 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1240 87.5 1.1e-16
XP_005267262 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102)  507 45.1  0.0012
XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102)  507 45.1  0.0012
XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159)  507 45.2  0.0013
XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360)  507 45.2  0.0014
XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384)  507 45.2  0.0014
XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417)  507 45.2  0.0015
NP_003932 (OMIM: 605056) neural Wiskott-Aldrich sy ( 505)  489 43.7  0.0015
NP_064450 (OMIM: 606373,616193) formin-2 isoform 2 (1722)  507 45.3  0.0017
NP_001292353 (OMIM: 606373,616193) formin-2 isofor (1726)  507 45.3  0.0017
NP_001026884 (OMIM: 610982,613237,614455) inverted (1240)  463 42.6  0.0078
NP_071934 (OMIM: 610982,613237,614455) inverted fo (1249)  463 42.6  0.0078
XP_005268062 (OMIM: 610982,613237,614455) PREDICTE (1272)  463 42.6  0.0079
XP_005268061 (OMIM: 610982,613237,614455) PREDICTE (1281)  463 42.6   0.008
XP_016877084 (OMIM: 610982,613237,614455) PREDICTE (1281)  463 42.6   0.008
NP_001300936 (OMIM: 124900,602121,616632) protein  (1250)  462 42.6  0.0082
XP_011535875 (OMIM: 124900,602121,616632) PREDICTE (1250)  462 42.6  0.0082
XP_011535874 (OMIM: 124900,602121,616632) PREDICTE (1260)  462 42.6  0.0082
NP_001073280 (OMIM: 124900,602121,616632) protein  (1263)  462 42.6  0.0082
NP_005210 (OMIM: 124900,602121,616632) protein dia (1272)  462 42.6  0.0083


>>NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome prot  (498 aa)
 initn: 3525 init1: 3525 opt: 3525  Z-score: 1140.6  bits: 220.6 E(85289): 8.6e-57
Smith-Waterman score: 3525; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498)

               10        20        30        40        50        60
pF1KB5 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE
              430       440       450       460       470       480

              490        
pF1KB5 YSDSEDDSSEFDEDDWSD
       ::::::::::::::::::
NP_008 YSDSEDDSSEFDEDDWSD
              490        

>>NP_001188333 (OMIM: 605875) wiskott-Aldrich syndrome p  (281 aa)
 initn: 1841 init1: 1841 opt: 1841  Z-score: 613.7  bits: 122.2 E(85289): 1.9e-27
Smith-Waterman score: 1841; 99.3% identity (99.6% similar) in 276 aa overlap (1-276:1-276)

               10        20        30        40        50        60
pF1KB5 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
       :::::::::::::::::::::::::::::::::: .                        
NP_001 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFRFSAAQG                   
              250       260       270       280                    

              310       320       330       340       350       360
pF1KB5 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD

>>NP_001278894 (OMIM: 605068) wiskott-Aldrich syndrome p  (499 aa)
 initn: 1190 init1: 1190 opt: 1690  Z-score: 563.0  bits: 113.7 E(85289): 1.3e-24
Smith-Waterman score: 1690; 53.5% identity (71.5% similar) in 512 aa overlap (1-498:1-499)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
NP_001 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:  :..:: .:.::: :::::::   :::::: :: .:::.:::.:::.. ..::.: :
NP_001 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       : . ::  : ::::: ::::::: :..::::::::::::::::::::::.:  ::::...
NP_001 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
              130       140       150       160       170       180

     180        190        200       210       220       230       
pF1KB5 KEK-KDNPNRGN-VNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGC
       .:: : ::::.. :: ::..:::::::. ::: ::. . .::  .:        .::   
NP_001 REKHKLNPNRNQQVNVRKVRTRKEEWERRKMGIEFMSDAKKLEQAGSAKEDRVPSGS--H
              190       200       210       220       230          

       240       250        260       270        280       290     
pF1KB5 VENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKRSSVV
       . .:   :::  :. .   .: .::..  ..::  ::  :  ....     :. .. .. 
NP_001 ASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARHMALN
      240       250       260       270         280       290      

         300       310       320       330       340       350     
pF1KB5 SPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSF
        :..::: ::  .: : .       :  :  :   :. :      ..  : :::: :: .
NP_001 RPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVI
        300       310              320       330       340         

          360          370       380          390        400       
pF1KB5 PP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPPPPPF
       :  .  :..:   :  :: ::.   :   ::    ::    ::::: ::::::::: :  
NP_001 PSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPG-
     350       360       370       380       390       400         

       410       420       430       440       450       460       
pF1KB5 TGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDVVG
       .. ...:   ::.... . . . : .::::::::.:::.:.::..:.:::::: ::. ::
NP_001 SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVG
      410       420       430       440       450       460        

        470       480       490        
pF1KB5 NDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       ::::::::::::::::::.::: ::::.::::
NP_001 NDVATILSRRIAVEYSDSDDDS-EFDENDWSD
      470       480       490          

>>XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Aldrich  (502 aa)
 initn: 869 init1: 869 opt: 1590  Z-score: 531.5  bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
XP_011 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:  :..:: .:.::: :::::::   :::::: :: .:::.:::.:::.. ..::.: :
XP_011 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       : . ::  : ::::: ::::::: :..::::::::::::::::::::::.:  ::::...
XP_011 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
              130       140       150       160       170       180

     180        190       200       210       220       230        
pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
       ..:. :. .:   . :: ..:..::. : . .:. .  ..:. : :  .   ..::..  
XP_011 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
              190       200       210        220         230       

           240       250        260       270        280       290 
pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
           . .:   :::  :. .   .: .::..  ..::  ::  :  ....     :. ..
XP_011 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
       240       250       260       270         280       290     

             300       310       320       330       340       350 
pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
        ..  :..::: ::  .: : .       :  :  :   :. :      ..  : :::: 
XP_011 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
         300       310              320       330       340        

              360          370       380          390        400   
pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
       :: .:  .  :..:   :  :: ::.   :   ::    ::    ::::: :::::::::
XP_011 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
      350       360       370       380       390       400        

           410       420       430       440       450       460   
pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
        :  .. ...:   ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
XP_011 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
      410        420       430       440       450       460       

            470       480       490        
pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::::::::::::::::::.::: ::::.::::
XP_011 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
       470       480       490        500  

>>XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Aldrich  (502 aa)
 initn: 869 init1: 869 opt: 1590  Z-score: 531.5  bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
XP_011 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:  :..:: .:.::: :::::::   :::::: :: .:::.:::.:::.. ..::.: :
XP_011 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       : . ::  : ::::: ::::::: :..::::::::::::::::::::::.:  ::::...
XP_011 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
              130       140       150       160       170       180

     180        190       200       210       220       230        
pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
       ..:. :. .:   . :: ..:..::. : . .:. .  ..:. : :  .   ..::..  
XP_011 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
              190       200       210        220         230       

           240       250        260       270        280       290 
pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
           . .:   :::  :. .   .: .::..  ..::  ::  :  ....     :. ..
XP_011 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
       240       250       260       270         280       290     

             300       310       320       330       340       350 
pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
        ..  :..::: ::  .: : .       :  :  :   :. :      ..  : :::: 
XP_011 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
         300       310              320       330       340        

              360          370       380          390        400   
pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
       :: .:  .  :..:   :  :: ::.   :   ::    ::    ::::: :::::::::
XP_011 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
      350       360       370       380       390       400        

           410       420       430       440       450       460   
pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
        :  .. ...:   ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
XP_011 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
      410        420       430       440       450       460       

            470       480       490        
pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::::::::::::::::::.::: ::::.::::
XP_011 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
       470       480       490        500  

>>NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome prot  (502 aa)
 initn: 869 init1: 869 opt: 1590  Z-score: 531.5  bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
NP_006 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:  :..:: .:.::: :::::::   :::::: :: .:::.:::.:::.. ..::.: :
NP_006 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       : . ::  : ::::: ::::::: :..::::::::::::::::::::::.:  ::::...
NP_006 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
              130       140       150       160       170       180

     180        190       200       210       220       230        
pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
       ..:. :. .:   . :: ..:..::. : . .:. .  ..:. : :  .   ..::..  
NP_006 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
              190       200       210        220         230       

           240       250        260       270        280       290 
pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
           . .:   :::  :. .   .: .::..  ..::  ::  :  ....     :. ..
NP_006 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
       240       250       260       270         280       290     

             300       310       320       330       340       350 
pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
        ..  :..::: ::  .: : .       :  :  :   :. :      ..  : :::: 
NP_006 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
         300       310              320       330       340        

              360          370       380          390        400   
pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
       :: .:  .  :..:   :  :: ::.   :   ::    ::    ::::: :::::::::
NP_006 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
      350       360       370       380       390       400        

           410       420       430       440       450       460   
pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
        :  .. ...:   ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
NP_006 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
      410        420       430       440       450       460       

            470       480       490        
pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::::::::::::::::::.::: ::::.::::
NP_006 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
       470       480       490        500  

>>XP_016866929 (OMIM: 605035) PREDICTED: wiskott-Aldrich  (558 aa)
 initn: 1082 init1: 896 opt: 1245  Z-score: 422.4  bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       . :::..:. ::::: ::::::::::.:::::.::::::::::::::::.:  :::::..
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
              130       140       150       160       170       180

     180       190       200       210                220          
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
       :.  : :.. .  ::  . :..::.:. .: :..:.  .:         : ...    : 
XP_016 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
               190       200       210       220       230         

         230                      240       250       260       270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
       : : ...:: .                 : : .  . :::       : :  .  .  : 
XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
     240       250       260       270              280       290  

                 280       290        300       310       320      
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
       :. .:     ..:.  :  .:  :. : :::. ::: ::: :  . .   :   . ::::
XP_016 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
            300       310         320       330       340       350

         330       340       350       360              370        
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
        ::    ::::: ... .:..::::.: .. :     ::::  ::     :: :   :  
XP_016 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
                  360       370       380       390       400      

         380        390         400                         410    
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
        :.:  :: :  . : ::::::::  :::              ::    : : : : :  
XP_016 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
        410       420       430       440       450       460      

                   420       430       440       450       460     
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
        : .::       : :.  .  :.::..::::: :: :::.:.:::.:::::::: :.. 
XP_016 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
         470       480       490       500       510       520     

          470       480       490        
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::                            
XP_016 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE 
         530       540       550         

>>XP_016866933 (OMIM: 605035) PREDICTED: wiskott-Aldrich  (558 aa)
 initn: 1082 init1: 896 opt: 1245  Z-score: 422.4  bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       . :::..:. ::::: ::::::::::.:::::.::::::::::::::::.:  :::::..
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
              130       140       150       160       170       180

     180       190       200       210                220          
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
       :.  : :.. .  ::  . :..::.:. .: :..:.  .:         : ...    : 
XP_016 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
               190       200       210       220       230         

         230                      240       250       260       270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
       : : ...:: .                 : : .  . :::       : :  .  .  : 
XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
     240       250       260       270              280       290  

                 280       290        300       310       320      
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
       :. .:     ..:.  :  .:  :. : :::. ::: ::: :  . .   :   . ::::
XP_016 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
            300       310         320       330       340       350

         330       340       350       360              370        
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
        ::    ::::: ... .:..::::.: .. :     ::::  ::     :: :   :  
XP_016 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
                  360       370       380       390       400      

         380        390         400                         410    
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
        :.:  :: :  . : ::::::::  :::              ::    : : : : :  
XP_016 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
        410       420       430       440       450       460      

                   420       430       440       450       460     
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
        : .::       : :.  .  :.::..::::: :: :::.:.:::.:::::::: :.. 
XP_016 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
         470       480       490       500       510       520     

          470       480       490        
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::                            
XP_016 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE 
         530       540       550         

>>XP_011534537 (OMIM: 605035) PREDICTED: wiskott-Aldrich  (558 aa)
 initn: 1082 init1: 896 opt: 1245  Z-score: 422.4  bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_011 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_011 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       . :::..:. ::::: ::::::::::.:::::.::::::::::::::::.:  :::::..
XP_011 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
              130       140       150       160       170       180

     180       190       200       210                220          
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
       :.  : :.. .  ::  . :..::.:. .: :..:.  .:         : ...    : 
XP_011 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
               190       200       210       220       230         

         230                      240       250       260       270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
       : : ...:: .                 : : .  . :::       : :  .  .  : 
XP_011 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
     240       250       260       270              280       290  

                 280       290        300       310       320      
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
       :. .:     ..:.  :  .:  :. : :::. ::: ::: :  . .   :   . ::::
XP_011 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
            300       310         320       330       340       350

         330       340       350       360              370        
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
        ::    ::::: ... .:..::::.: .. :     ::::  ::     :: :   :  
XP_011 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
                  360       370       380       390       400      

         380        390         400                         410    
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
        :.:  :: :  . : ::::::::  :::              ::    : : : : :  
XP_011 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
        410       420       430       440       450       460      

                   420       430       440       450       460     
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
        : .::       : :.  .  :.::..::::: :: :::.:.:::.:::::::: :.. 
XP_011 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
         470       480       490       500       510       520     

          470       480       490        
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::                            
XP_011 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE 
         530       540       550         

>>XP_016866932 (OMIM: 605035) PREDICTED: wiskott-Aldrich  (558 aa)
 initn: 1082 init1: 896 opt: 1245  Z-score: 422.4  bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)

               10         20        30        40        50         
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
       :::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
       .:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
       . :::..:. ::::: ::::::::::.:::::.::::::::::::::::.:  :::::..
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
              130       140       150       160       170       180

     180       190       200       210                220          
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
       :.  : :.. .  ::  . :..::.:. .: :..:.  .:         : ...    : 
XP_016 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
               190       200       210       220       230         

         230                      240       250       260       270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
       : : ...:: .                 : : .  . :::       : :  .  .  : 
XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
     240       250       260       270              280       290  

                 280       290        300       310       320      
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
       :. .:     ..:.  :  .:  :. : :::. ::: ::: :  . .   :   . ::::
XP_016 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
            300       310         320       330       340       350

         330       340       350       360              370        
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
        ::    ::::: ... .:..::::.: .. :     ::::  ::     :: :   :  
XP_016 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
                  360       370       380       390       400      

         380        390         400                         410    
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
        :.:  :: :  . : ::::::::  :::              ::    : : : : :  
XP_016 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
        410       420       430       440       450       460      

                   420       430       440       450       460     
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
        : .::       : :.  .  :.::..::::: :: :::.:.:::.:::::::: :.. 
XP_016 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
         470       480       490       500       510       520     

          470       480       490        
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
       . ::::                            
XP_016 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE 
         530       540       550         




498 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 15:28:40 2016 done: Sat Nov  5 15:28:42 2016
 Total Scan time: 11.660 Total Display time:  0.090

Function used was FASTA [36.3.4 Apr, 2011]
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