Result of FASTA (omim) for pF1KB6672
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6672, 454 aa
  1>>>pF1KB6672 454 - 454 aa - 454 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6855+/-0.000358; mu= 16.4259+/- 0.022
 mean_var=81.4733+/-15.831, 0's: 0 Z-trim(114.7): 77  B-trim: 421 in 1/51
 Lambda= 0.142091
 statistics sampled from 24556 (24637) to 24556 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.289), width:  16
 Scan time:  8.240

The best scores are:                                      opt bits E(85289)
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 3080 641.2 1.7e-183
NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 2466 515.3 1.2e-145
XP_011513119 (OMIM: 112265) PREDICTED: bone morpho ( 357) 2275 476.1 6.7e-134
NP_001316685 (OMIM: 112265) bone morphogenetic pro ( 348) 2273 475.7 8.8e-134
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 1643 346.6   9e-95
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 1632 344.3 3.7e-94
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 1562 329.8 4.9e-90
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 1218 259.4 1.2e-68
XP_011540324 (OMIM: 602284) PREDICTED: bone morpho ( 357)  940 202.4 1.6e-51
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427)  645 142.0   3e-33
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501)  534 119.3 2.4e-26
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501)  534 119.3 2.4e-26
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501)  534 119.3 2.4e-26
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345)  502 112.6 1.7e-24
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345)  502 112.6 1.7e-24
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408)  502 112.7 1.9e-24
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408)  502 112.7 1.9e-24
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408)  502 112.7 1.9e-24
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408)  502 112.7 1.9e-24
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240)  488 109.6 9.2e-24
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396)  488 109.8 1.4e-23
XP_016857645 (OMIM: 602284) PREDICTED: bone morpho ( 236)  474 106.8 6.6e-23
XP_011540327 (OMIM: 602284) PREDICTED: bone morpho ( 230)  466 105.1   2e-22
XP_005271206 (OMIM: 602284) PREDICTED: bone morpho ( 231)  466 105.1   2e-22
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450)  452 102.4 2.5e-21
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455)  449 101.8 3.9e-21
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364)  421 96.0 1.8e-19
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472)  404 92.6 2.4e-18
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429)  398 91.4 5.3e-18
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372)  396 90.9 6.2e-18
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424)  383 88.3 4.4e-17
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392)  371 85.8 2.3e-16
XP_016857644 (OMIM: 602284) PREDICTED: bone morpho ( 382)  367 85.0 3.9e-16
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478)  368 85.2 4.1e-16
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214)  343 79.9 7.4e-15
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347)  343 80.0 1.1e-14
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426)  344 80.3 1.1e-14
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426)  344 80.3 1.1e-14
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483)  344 80.3 1.2e-14
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548)  344 80.3 1.4e-14
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407)  298 70.8 7.5e-12
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276)  290 69.1 1.7e-11
XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366)  290 69.2 2.1e-11
NP_001275754 (OMIM: 601918) growth/differentiation ( 366)  290 69.2 2.1e-11
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366)  290 69.2 2.1e-11
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366)  290 69.2 2.1e-11
NP_001275757 (OMIM: 601918) growth/differentiation ( 366)  290 69.2 2.1e-11
NP_001275755 (OMIM: 601918) growth/differentiation ( 366)  290 69.2 2.1e-11
NP_001275756 (OMIM: 601918) growth/differentiation ( 366)  290 69.2 2.1e-11
NP_001275753 (OMIM: 601918) growth/differentiation ( 366)  290 69.2 2.1e-11


>>NP_066551 (OMIM: 112265) bone morphogenetic protein 5   (454 aa)
 initn: 3080 init1: 3080 opt: 3080  Z-score: 3415.2  bits: 641.2 E(85289): 1.7e-183
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454)

               10        20        30        40        50        60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
              370       380       390       400       410       420

              430       440       450    
pF1KB6 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
       ::::::::::::::::::::::::::::::::::
NP_066 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
              430       440       450    

>>NP_001316683 (OMIM: 112265) bone morphogenetic protein  (417 aa)
 initn: 2799 init1: 2459 opt: 2466  Z-score: 2735.5  bits: 515.3 E(85289): 1.2e-145
Smith-Waterman score: 2729; 91.9% identity (91.9% similar) in 454 aa overlap (1-454:1-417)

               10        20        30        40        50        60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
       ::::::::                                     :::::::::::::::
NP_001 SFRDLGWQ-------------------------------------VHLMFPDHVPKPCCA
                                                   370       380   

              430       440       450    
pF1KB6 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
       ::::::::::::::::::::::::::::::::::
NP_001 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
           390       400       410       

>>XP_011513119 (OMIM: 112265) PREDICTED: bone morphogene  (357 aa)
 initn: 2304 init1: 2275 opt: 2275  Z-score: 2524.9  bits: 476.1 E(85289): 6.7e-134
Smith-Waterman score: 2275; 99.7% identity (100.0% similar) in 343 aa overlap (1-343:1-343)

               10        20        30        40        50        60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
       ::::::::::::::::::::::::::::::::::::::::::.                 
XP_011 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGETLHKTTRWNSLDFS   
              310       320       330       340       350          

              370       380       390       400       410       420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA

>>NP_001316685 (OMIM: 112265) bone morphogenetic protein  (348 aa)
 initn: 2273 init1: 2273 opt: 2273  Z-score: 2522.8  bits: 475.7 E(85289): 8.8e-134
Smith-Waterman score: 2273; 100.0% identity (100.0% similar) in 342 aa overlap (1-342:1-342)

               10        20        30        40        50        60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
       ::::::::::::::::::::::::::::::::::::::::::                  
NP_001 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGGSSDVS            
              310       320       330       340                    

              370       380       390       400       410       420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA

>>NP_001709 (OMIM: 112266) bone morphogenetic protein 6   (513 aa)
 initn: 1074 init1: 810 opt: 1643  Z-score: 1822.4  bits: 346.6 E(85289): 9e-95
Smith-Waterman score: 1742; 59.3% identity (79.6% similar) in 450 aa overlap (36-454:64-513)

          10        20        30        40        50        60     
pF1KB6 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP
                                     :.:.::::...:.::.:.::::.:::::::
NP_001 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
            40        50        60        70        80        90   

                                     70        80        90        
pF1KB6 RPFS---------------------------PGKQASSAPLFMLDLYNAMTNEENPE-ES
       ::.                            :  . .::::::::::::.. ... .  :
NP_001 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGAS
           100       110       120       130       140       150   

       100        110       120        130       140       150     
pF1KB6 EYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDAD
       :   . :  .:.  ....  :    ..:  : .:      .  . ::.: .:. ::::::
NP_001 EGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDAD
           160       170       180       190       200       210   

         160       170       180       190       200       210     
pF1KB6 MVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIK
       :::::::::: ::.:: ..::.:::.:.:.:::.::.:::::::::::   . :.:.:. 
NP_001 MVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL
           220       230       240       250       260       270   

         220       230       240       250       260       270     
pF1KB6 ISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAET
       :::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: . :
NP_001 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVT
           280       290       300       310       320       330   

         280       290       300       310        320       330    
pF1KB6 GDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAAN-KRKNQNRNKSSSHQD
        ::  .. ..::::::.:: .::::::::::.::: .:..:.:. .:..:.::.:.. ::
NP_001 RDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQD
           340       350       360       370       380       390   

          340       350       360       370       380       390    
pF1KB6 SSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHM
        .:.::..:::.:: : ::.::::::::.:::::::::::.:::: ::::::::::::::
NP_001 VARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHM
           400       410       420       430       440       450   

          400       410       420       430       440       450    
pF1KB6 NATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
       ::::::::::::::: :..:::::::::::::::::::::.::::::::::::::.::::
NP_001 NATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
           460       470       480       490       500       510   

>>NP_001710 (OMIM: 112267) bone morphogenetic protein 7   (431 aa)
 initn: 1098 init1: 874 opt: 1632  Z-score: 1811.3  bits: 344.3 E(85289): 3.7e-94
Smith-Waterman score: 1898; 64.7% identity (84.2% similar) in 442 aa overlap (15-454:17-431)

                 10        20        30         40        50       
pF1KB6   MHLTVFLLKGIVGFLWSCWVLVGYAKGGLG-DNHVHSSFIYRRLRNHERREIQREILS
                       ::.   :.  : . .. ::.::::::.::::..::::.::::::
NP_001 MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILS
               10        20        30        40        50        60

        60        70        80        90       100       110       
pF1KB6 ILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYP
       ::::::::::   ::. .:::.:::::::::. ::.                 :.  :  
NP_001 ILGLPHRPRPHLQGKH-NSAPMFMLDLYNAMAVEEG-----------------GGPGGQG
               70         80        90                        100  

       120       130       140       150       160       170       
pF1KB6 ASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHY
        :   :: .  .:      ::.::::::.:..::.:::::::::::::.::.: : : :.
NP_001 FS---YPYKAVFS------TQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHH
               110             120       130       140       150   

       180       190       200       210       220       230       
pF1KB6 KEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDT
       .::::::..::.::::::::::::::   .::.:::..::.::...:. .:..::::::.
NP_001 REFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDS
           160       170       180       190       200       210   

       240       250       260       270       280       290       
pF1KB6 RKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSK
       :   : . ::::::::.::::::.::..:::::: .:: ::.::: : :::.::.:::.:
NP_001 RTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNK
           220       230       240       250       260       270   

       300       310        320       330       340       350      
pF1KB6 QPFMVAFFKASEVLLRSVRAA-NKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKH
       ::::::::::.:: .::.:.. .:...:::.:. ..:.. ::..:.. ..:.:.::::::
NP_001 QPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKH
           280       290       300       310       320       330   

        360       370       380       390       400       410      
pF1KB6 ELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPK
       :::::::::::::::::::::::.::.:::.::::..::::::::::::::.. :. :::
NP_001 ELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPK
           340       350       360       370       380       390   

        420       430       440       450    
pF1KB6 PCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
       ::::::.::::::::::::::::::::::::::.::::
NP_001 PCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
           400       410       420       430 

>>XP_016866687 (OMIM: 112265) PREDICTED: bone morphogene  (239 aa)
 initn: 1562 init1: 1562 opt: 1562  Z-score: 1737.5  bits: 329.8 E(85289): 4.9e-90
Smith-Waterman score: 1562; 99.6% identity (99.6% similar) in 229 aa overlap (226-454:11-239)

         200       210       220       230       240       250     
pF1KB6 AEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVT
                                     : ::::::::::::::::::::::::::::
XP_016                     MEAERAQVLPTVRDADLFLLDTRKAQALDVGWLVFDITVT
                                   10        20        30        40

         260       270       280       290       300       310     
pF1KB6 SNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSV
               50        60        70        80        90       100

         320       330       340       350       360       370     
pF1KB6 RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPE
              110       120       130       140       150       160

         380       390       400       410       420       430     
pF1KB6 GYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDS
              170       180       190       200       210       220

         440       450    
pF1KB6 SNVILKKYRNMVVRSCGCH
       :::::::::::::::::::
XP_016 SNVILKKYRNMVVRSCGCH
              230         

>>NP_001711 (OMIM: 602284) bone morphogenetic protein 8B  (402 aa)
 initn: 895 init1: 765 opt: 1218  Z-score: 1353.1  bits: 259.4 E(85289): 1.2e-68
Smith-Waterman score: 1342; 47.5% identity (72.3% similar) in 455 aa overlap (8-454:1-402)

               10        20        30            40        50      
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDN----HVHSSFIYRRLRNHERREIQREIL
              . .. : ::    :.: :  .:: .    .   .   :::  .:::..:::::
NP_001        MTALPGPLW----LLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREIL
                          10        20        30        40         

         60        70           80        90       100       110   
pF1KB6 SILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGAR
       ..:::: :::: .:   ..  .::::::::::.::..... .                  
NP_001 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED------------------
      50        60        70        80        90                   

           120       130       140       150       160       170   
pF1KB6 KGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQ
        : ::      ::                        :. ::.::::::.::::. ..::
NP_001 -GAPAE-----RR------------------------LGRADLVMSFVNMVERDRALGHQ
                                           100       110       120 

           180       190       200       210       220       230   
pF1KB6 RRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLF
       . :.::::::::::: :::::::::::::  : . . :.:...:..:...: .::..:::
NP_001 EPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVSMFQVVQEQSNRESDLF
             130       140       150        160       170       180

           240       250       260       270       280       290   
pF1KB6 LLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQG
       .:: .  .: : ::::.:.:..:. :... ...:::.: .:: ::.:..   :::.:...
NP_001 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
              190       200       210       220       230       240

           300       310       320       330       340        350  
pF1KB6 PQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSV-GDYNTSEQKQA
       :.:.:::.:.::.::   .:. ::.   . .. .::.   ...:. ..  : . :. .:.
NP_001 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
              250       260       270       280       290       300

            360       370       380       390       400       410  
pF1KB6 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPD
       :..:::::::.:::: ::.:::.::.:.::.:::::::.. ::::::::.:.:::::.::
NP_001 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD
              310       320       330       340       350       360

            420       430       440       450    
pF1KB6 HVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
        ::: :::::::.: ::::.:.:.::::.:.:::::..::::
NP_001 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
              370       380       390       400  

>>XP_011540324 (OMIM: 602284) PREDICTED: bone morphogene  (357 aa)
 initn: 904 init1: 484 opt: 940  Z-score: 1045.9  bits: 202.4 E(85289): 1.6e-51
Smith-Waterman score: 1064; 44.1% identity (69.7% similar) in 406 aa overlap (8-405:1-353)

               10        20        30            40        50      
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDN----HVHSSFIYRRLRNHERREIQREIL
              . .. : ::    :.: :  .:: .    .   .   :::  .:::..:::::
XP_011        MTALPGPLW----LLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREIL
                          10        20        30        40         

         60        70           80        90       100       110   
pF1KB6 SILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGAR
       ..:::: :::: .:   ..  .::::::::::.::..... .                  
XP_011 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED------------------
      50        60        70        80        90                   

           120       130       140       150       160       170   
pF1KB6 KGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQ
        : ::      ::                        :. ::.::::::.::::. ..::
XP_011 -GAPAE-----RR------------------------LGRADLVMSFVNMVERDRALGHQ
                                           100       110       120 

           180       190       200       210       220       230   
pF1KB6 RRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLF
       . :.::::::::::: :::::::::::::  : . . :.:...:..:...: .::..:::
XP_011 EPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVSMFQVVQEQSNRESDLF
             130       140       150        160       170       180

           240       250       260       270       280       290   
pF1KB6 LLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQG
       .:: .  .: : ::::.:.:..:. :... ...:::.: .:: ::.:..   :::.:...
XP_011 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
              190       200       210       220       230       240

           300       310       320       330       340        350  
pF1KB6 PQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSV-GDYNTSEQKQA
       :.:.:::.:.::.::   .:. ::.   . .. .::.   ...:. ..  : . :. .:.
XP_011 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
              250       260       270       280       290       300

            360       370       380       390       400       410  
pF1KB6 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPD
       :..:::::::.:::: ::.:::.::.:.::.:::::::.. ::::::::.:.:       
XP_011 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLEVQR   
              310       320       330       340       350          

            420       430       440       450    
pF1KB6 HVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH

>>XP_011540326 (OMIM: 602284) PREDICTED: bone morphogene  (427 aa)
 initn: 1213 init1: 617 opt: 645  Z-score: 717.9  bits: 142.0 E(85289): 3e-33
Smith-Waterman score: 1186; 43.5% identity (67.5% similar) in 480 aa overlap (8-454:1-427)

               10        20        30            40        50      
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDN----HVHSSFIYRRLRNHERREIQREIL
              . .. : ::    :.: :  .:: .    .   .   :::  .:::..:::::
XP_011        MTALPGPLW----LLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREIL
                          10        20        30        40         

         60        70           80        90       100       110   
pF1KB6 SILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGAR
       ..:::: :::: .:   ..  .::::::::::.::..... .                  
XP_011 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED------------------
      50        60        70        80        90                   

           120       130       140       150       160       170   
pF1KB6 KGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQ
        : ::      ::                        :. ::.::::::.::::. ..::
XP_011 -GAPAE-----RR------------------------LGRADLVMSFVNMVERDRALGHQ
                                           100       110       120 

           180       190       200       210       220       230   
pF1KB6 RRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLF
       . :.::::::::::: :::::::::::::  : . . :.:...:..:...: .::..:::
XP_011 EPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVSMFQVVQEQSNRESDLF
             130       140       150        160       170       180

           240       250       260       270       280             
pF1KB6 LLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSIN----VKSAGL-
       .:: .  .: : ::::.:.:..:. :... ...:::.: .:: ::.. .    .:.. : 
XP_011 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGETWTGWGWTKDSRLQ
              190       200       210       220       230       240

           290                   300          310       320        
pF1KB6 -----VGRQ---------GPQ---SKQPFMVAF---FKASEVLLRSVRAANKRKNQNRNK
            ..:          ::    ...:..  .     ::   .:. ::.   . .. .:
XP_011 MWKLRLSRTPWVLSLHAPGPAQAPAERPLLCLLQGHCPASPSPIRTPRAVRPLRRRQPKK
              250       260       270       280       290       300

      330       340        350       360       370       380       
pF1KB6 SSSHQDSSRMSSV-GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECS
       :.   ...:. ..  : . :. .:.:..:::::::.:::: ::.:::.::.:.::.::::
XP_011 SNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECS
              310       320       330       340       350       360

       390       400       410       420       430       440       
pF1KB6 FPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMV
       :::.. ::::::::.:.:::::.:: ::: :::::::.: ::::.:.:.::::.:.::::
XP_011 FPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMV
              370       380       390       400       410       420

       450    
pF1KB6 VRSCGCH
       :..::::
XP_011 VKACGCH
              




454 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 11:20:17 2016 done: Sat Nov  5 11:20:18 2016
 Total Scan time:  8.240 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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