FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9171, 669 aa 1>>>pF1KB9171 669 - 669 aa - 669 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0047+/-0.000364; mu= 8.2793+/- 0.023 mean_var=169.5634+/-35.174, 0's: 0 Z-trim(119.7): 96 B-trim: 1413 in 1/52 Lambda= 0.098494 statistics sampled from 33859 (33956) to 33859 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.738), E-opt: 0.2 (0.398), width: 16 Scan time: 11.280 The best scores are: opt bits E(85289) NP_114408 (OMIM: 608544) histone deacetylase 10 is ( 669) 4519 654.5 3.6e-187 NP_001152758 (OMIM: 608544) histone deacetylase 10 ( 649) 2665 391.0 7.2e-108 XP_016884676 (OMIM: 300272,300863) PREDICTED: hist ( 622) 1378 208.1 7.8e-53 NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52 NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52 NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52 NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 1378 208.3 1.3e-52 NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 1378 208.3 1.3e-52 NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 1378 208.4 1.3e-52 XP_011510532 (OMIM: 605314) PREDICTED: histone dea ( 673) 744 118.1 1.1e-25 XP_016860884 (OMIM: 605314) PREDICTED: histone dea ( 917) 744 118.2 1.4e-25 XP_011510529 (OMIM: 605314) PREDICTED: histone dea (1041) 744 118.2 1.5e-25 XP_006712942 (OMIM: 605314) PREDICTED: histone dea (1062) 744 118.2 1.6e-25 XP_006712943 (OMIM: 605314) PREDICTED: histone dea (1062) 744 118.2 1.6e-25 XP_011510528 (OMIM: 605314) PREDICTED: histone dea (1065) 744 118.2 1.6e-25 XP_016860883 (OMIM: 605314) PREDICTED: histone dea (1069) 744 118.2 1.6e-25 XP_011510527 (OMIM: 605314) PREDICTED: histone dea (1079) 744 118.2 1.6e-25 NP_006028 (OMIM: 605314) histone deacetylase 4 [Ho (1084) 744 118.2 1.6e-25 XP_011510526 (OMIM: 605314) PREDICTED: histone dea (1084) 744 118.2 1.6e-25 XP_011510523 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25 XP_006712941 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25 XP_011510524 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25 XP_011510525 (OMIM: 605314) PREDICTED: histone dea (1089) 744 118.2 1.6e-25 XP_011510522 (OMIM: 605314) PREDICTED: histone dea (1090) 744 118.2 1.6e-25 XP_011510521 (OMIM: 605314) PREDICTED: histone dea (1103) 744 118.2 1.6e-25 XP_011510520 (OMIM: 605314) PREDICTED: histone dea (1108) 744 118.2 1.6e-25 XP_006712940 (OMIM: 605314) PREDICTED: histone dea (1108) 744 118.2 1.6e-25 XP_011510519 (OMIM: 605314) PREDICTED: histone dea (1113) 744 118.2 1.6e-25 NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 726 115.6 9e-25 NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 726 115.6 9e-25 XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 726 115.6 9e-25 XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 726 115.7 9e-25 XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 726 115.7 9.1e-25 XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 726 115.7 9.1e-25 XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 726 115.7 9.1e-25 XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 726 115.7 9.1e-25 XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 726 115.7 9.1e-25 XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 726 115.7 9.1e-25 NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 726 115.7 9.1e-25 XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 726 115.7 9.3e-25 NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 726 115.7 9.3e-25 XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 726 115.7 9.3e-25 NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 726 115.7 9.3e-25 XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 726 115.7 9.3e-25 XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 726 115.7 9.3e-25 XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 726 115.7 9.3e-25 XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 726 115.7 9.3e-25 XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 726 115.7 9.3e-25 XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 726 115.7 9.3e-25 XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 726 115.7 9.4e-25 >>NP_114408 (OMIM: 608544) histone deacetylase 10 isofor (669 aa) initn: 4519 init1: 4519 opt: 4519 Z-score: 3481.2 bits: 654.5 E(85289): 3.6e-187 Smith-Waterman score: 4519; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669) 10 20 30 40 50 60 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 610 620 630 640 650 660 pF1KB9 LQCHPHLVA ::::::::: NP_114 LQCHPHLVA >>NP_001152758 (OMIM: 608544) histone deacetylase 10 iso (649 aa) initn: 2665 init1: 2665 opt: 2665 Z-score: 2057.6 bits: 391.0 E(85289): 7.2e-108 Smith-Waterman score: 4336; 97.0% identity (97.0% similar) in 669 aa overlap (1-669:1-649) 10 20 30 40 50 60 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV ::::::::::: ::::::::::::::::::::::::::::: NP_001 AFLHLLLPLAF--------------------EGQMQATPECFAHLTQLLQVLAGGRVCAV 250 260 270 280 310 320 330 340 350 360 pF1KB9 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB9 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB9 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB9 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB9 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB9 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 590 600 610 620 630 640 pF1KB9 LQCHPHLVA ::::::::: NP_001 LQCHPHLVA >>XP_016884676 (OMIM: 300272,300863) PREDICTED: histone (622 aa) initn: 1375 init1: 1328 opt: 1378 Z-score: 1069.5 bits: 208.1 E(85289): 7.8e-53 Smith-Waterman score: 1378; 52.3% identity (78.1% similar) in 388 aa overlap (2-383:99-484) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: XP_016 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: XP_016 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: XP_016 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 190 200 210 220 230 240 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. XP_016 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: XP_016 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . XP_016 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 370 380 390 400 410 420 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLPGG : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: XP_016 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 430 440 450 460 470 480 390 400 410 420 430 440 pF1KB9 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWA XP_016 TWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPAT 490 500 510 520 530 540 >-- initn: 344 init1: 258 opt: 314 Z-score: 252.4 bits: 57.0 E(85289): 2.5e-07 Smith-Waterman score: 314; 44.3% identity (67.9% similar) in 131 aa overlap (3-132:495-621) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLT :.::: ..: :::. . :. :.:. XP_016 EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEV--PQRIL 470 480 490 500 510 520 40 50 60 70 80 90 pF1KB9 AALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDA . ::.. :: ::: :. : :.: :: :: :::. .: :. . .::. :..::. XP_016 RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDS 530 540 550 560 570 580 100 110 120 130 140 150 pF1KB9 IYFHPSTFHCARLAAGAGLQLVDAVLTGAVQN-GLALVRPPGHHGQRAAANGFCVFNNVA ::. :::: ::.::.::. .::.:::.: . ::. :: XP_016 IYICPSTFACAQLATGAACRLVEAVLSGEDPDCGLGC--PPR 590 600 610 620 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA >>NP_001308157 (OMIM: 300272,300863) histone deacetylase (1215 aa) initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52 Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 360 370 380 390 400 410 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP-- : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 420 430 440 450 460 470 390 400 410 420 pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD :: . : . . :: . : : .: : .. :.: : NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR 480 490 500 510 520 430 440 450 460 pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY :: : .. .. : :.. .: : : : NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 530 540 550 560 570 580 470 480 490 500 510 pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA- :....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: : NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW 590 600 610 620 630 640 520 530 540 pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P . . . . .: : :..... : :.:. .. : :.. : NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP 650 660 670 680 690 700 550 560 570 580 590 pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG : . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: : NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG 710 720 730 740 750 760 600 610 620 630 640 650 pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK ::.::.. .:: NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR 770 780 790 800 810 820 >>NP_001308155 (OMIM: 300272,300863) histone deacetylase (1215 aa) initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52 Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 360 370 380 390 400 410 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP-- : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 420 430 440 450 460 470 390 400 410 420 pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD :: . : . . :: . : : .: : .. :.: : NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR 480 490 500 510 520 430 440 450 460 pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY :: : .. .. : :.. .: : : : NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 530 540 550 560 570 580 470 480 490 500 510 pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA- :....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: : NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW 590 600 610 620 630 640 520 530 540 pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P . . . . .: : :..... : :.:. .. : :.. : NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP 650 660 670 680 690 700 550 560 570 580 590 pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG : . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: : NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG 710 720 730 740 750 760 600 610 620 630 640 650 pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK ::.::.. .:: NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR 770 780 790 800 810 820 >>NP_001308156 (OMIM: 300272,300863) histone deacetylase (1215 aa) initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52 Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 360 370 380 390 400 410 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP-- : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 420 430 440 450 460 470 390 400 410 420 pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD :: . : . . :: . : : .: : .. :.: : NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR 480 490 500 510 520 430 440 450 460 pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY :: : .. .. : :.. .: : : : NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 530 540 550 560 570 580 470 480 490 500 510 pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA- :....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: : NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW 590 600 610 620 630 640 520 530 540 pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P . . . . .: : :..... : :.:. .. : :.. : NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP 650 660 670 680 690 700 550 560 570 580 590 pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG : . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: : NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG 710 720 730 740 750 760 600 610 620 630 640 650 pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK ::.::.. .:: NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR 770 780 790 800 810 820 >>NP_006035 (OMIM: 300272,300863) histone deacetylase 6 (1215 aa) initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52 Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: NP_006 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: NP_006 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: NP_006 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. NP_006 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: NP_006 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . NP_006 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 360 370 380 390 400 410 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP-- : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: NP_006 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 420 430 440 450 460 470 390 400 410 420 pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD :: . : . . :: . : : .: : .. :.: : NP_006 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR 480 490 500 510 520 430 440 450 460 pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY :: : .. .. : :.. .: : : : NP_006 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 530 540 550 560 570 580 470 480 490 500 510 pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA- :....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: : NP_006 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW 590 600 610 620 630 640 520 530 540 pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P . . . . .: : :..... : :.:. .. : :.. : NP_006 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP 650 660 670 680 690 700 550 560 570 580 590 pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG : . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: : NP_006 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG 710 720 730 740 750 760 600 610 620 630 640 650 pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK ::.::.. .:: NP_006 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR 770 780 790 800 810 820 >>NP_001308158 (OMIM: 300272,300863) histone deacetylase (1215 aa) initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.4 bits: 208.3 E(85289): 1.3e-52 Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:85-779) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 360 370 380 390 400 410 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP-- : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 420 430 440 450 460 470 390 400 410 420 pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD :: . : . . :: . : : .: : .. :.: : NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR 480 490 500 510 520 430 440 450 460 pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY :: : .. .. : :.. .: : : : NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 530 540 550 560 570 580 470 480 490 500 510 pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA- :....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: : NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW 590 600 610 620 630 640 520 530 540 pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P . . . . .: : :..... : :.:. .. : :.. : NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP 650 660 670 680 690 700 550 560 570 580 590 pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG : . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: : NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG 710 720 730 740 750 760 600 610 620 630 640 650 pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK ::.::.. .:: NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR 770 780 790 800 810 820 >>NP_001308154 (OMIM: 300272,300863) histone deacetylase (1229 aa) initn: 1445 init1: 1328 opt: 1378 Z-score: 1065.3 bits: 208.4 E(85289): 1.3e-52 Smith-Waterman score: 1400; 39.9% identity (63.3% similar) in 701 aa overlap (2-610:99-793) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERL ::.:: :... . :::: : :::: NP_001 KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSF--PEGPERL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB9 TAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD : ..: :.:: .::. ..:: : .::: :::: ::..:.. :: ... ::..:. .: NP_001 HAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYD 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB9 AIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVA ..:.::... :: ::.:. :.:::::: . ..::.:..::::::.:.. .:.:.::.:: NP_001 SVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVA 190 200 210 220 230 240 160 170 180 190 200 210 pF1KB9 IAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDA .:: .:.::: ..:.:.:::::::::: :. :..:::::::: ::::.::::: :. :. NP_001 VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB9 DAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDP ...: ::: :.:.:.::::::: .:::.:::::.:::.:.::.:.::::.::::. ::: NP_001 STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDP 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB9 EGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSG .:.: ::: ::.::.::. ::::.. :::::.:..:::.: ...:::::: : : . NP_001 KGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLES 370 380 390 400 410 420 340 350 360 370 380 pF1KB9 PMAPCQSALESIQSARAAQAPHWKSLQQQDVTA----VPMSPSSHSPEGRP--PPLLP-- : :::.:: :.. : : : :. : .. :. . . .: : : ::.:: NP_001 PGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPIL 430 440 450 460 470 480 390 400 410 420 pF1KB9 GGPVCKAAASAPSSLLDQPCL--C----------PAPSVRTAVALTTPDIT---LVLPPD :: . : . . :: . : : .: : .. :.: : NP_001 TWPVLQ---SRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPR 490 500 510 520 530 540 430 440 450 460 pF1KB9 VIQQEASALREETEAWA---RPHESLAREE--------------------ALTALGKLLY :: : .. .. : :.. .: : : : NP_001 PAT-EAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 550 560 570 580 590 600 470 480 490 500 510 pF1KB9 LLDGMLDGQVNSGIAAT--PASAA---AA-------TLDVAVRRG--LSHGAQRLLCVA- :....:.:.: .: :.. :. : :: .. ::.:.. .: : :.: : NP_001 LVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDW 610 620 630 640 650 660 520 530 540 pF1KB9 -LGQLDRPPDLAHDGRS-LWLNIR----------GKEAAALSM-------FHVSTPL--P . . . . .: : :..... : :.:. .. : :.. : NP_001 DVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGP 670 680 690 700 710 720 550 560 570 580 590 pF1KB9 VM-TGGFLSCILGLVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRG : . .:. ::::.:: :.:.::::. : : : : .:.. : :. .: : NP_001 RMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMG 730 740 750 760 770 780 600 610 620 630 640 650 pF1KB9 LAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWK ::.::.. .:: NP_001 LASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHR 790 800 810 820 830 840 >>XP_011510532 (OMIM: 605314) PREDICTED: histone deacety (673 aa) initn: 721 init1: 412 opt: 744 Z-score: 582.1 bits: 118.1 E(85289): 1.1e-25 Smith-Waterman score: 806; 37.6% identity (64.9% similar) in 388 aa overlap (3-364:243-627) 10 20 30 pF1KB9 MGTALVYHEDMTATRLLWDDPECEIERPERLT :.::: : . . . :. :. XP_011 HRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQ 220 230 240 250 260 270 40 50 60 70 80 90 pF1KB9 AALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQA--LSGQF . .::.. ::. .: . .:.:. ::: ::: : .:. :. :....:.. : :.. XP_011 SIWSRLQETGLRGKCECIRGRKATLEELQTVHS-EAHTLLYGTNPLNRQKLDSKKLLGSL 280 290 300 310 320 330 100 110 120 130 pF1KB9 DAIYFH-P------------STFHCA---RLAAGAGLQLVDAVLTGAVQNGLALVRPPGH ... . : . : : :::.: ..:: : :: ..::.:.:::::: XP_011 ASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGH 340 350 360 370 380 390 140 150 160 170 180 190 pF1KB9 HGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSW :..... ::: ::.::.:: .:. .. .::.::::::::.: : : .::::::.: XP_011 HAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSL 400 410 420 430 440 450 200 210 220 230 240 250 pF1KB9 HRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWN---QVGMGNADYVAAFLHLLLPLAF :::. : :.: . : :: : :.::.::. .. . ::.:.:.::: ...:.: XP_011 HRYDDGNFFP--GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIAS 460 470 480 490 500 260 270 280 290 300 pF1KB9 EFDPELVLVSAGFDSAIGDPE--GQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLES :: :..::::.:::.. : : : .. . .::..::. :. :::::. .::::. : . XP_011 EFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTA 510 520 530 540 550 560 310 320 330 340 350 360 pF1KB9 LAESVCMTVQTLLG---DPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVP . .. :..::: :: : . : .:..:.... .. .:. ::. :: XP_011 ICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGR 570 580 590 600 610 620 370 380 390 400 410 420 pF1KB9 MSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLP XP_011 SLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL 630 640 650 660 670 669 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:00:42 2016 done: Fri Nov 4 17:00:44 2016 Total Scan time: 11.280 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]