Result of FASTA (omim) for pF1KB8830
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8830, 440 aa
  1>>>pF1KB8830 440 - 440 aa - 440 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.3047+/-0.000421; mu= 12.4708+/- 0.026
 mean_var=88.3772+/-18.234, 0's: 0 Z-trim(112.9): 85  B-trim: 648 in 1/48
 Lambda= 0.136428
 statistics sampled from 21908 (21995) to 21908 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.258), width:  16
 Scan time:  8.230

The best scores are:                                      opt bits E(85289)
XP_011534727 (OMIM: 616337) PREDICTED: suppressor  ( 440) 3048 610.3 3.2e-174
XP_011534728 (OMIM: 616337) PREDICTED: suppressor  ( 440) 3048 610.3 3.2e-174
NP_955453 (OMIM: 616337) suppressor of cytokine si ( 440) 3048 610.3 3.2e-174
NP_543143 (OMIM: 616337) suppressor of cytokine si ( 440) 3048 610.3 3.2e-174
NP_659198 (OMIM: 607094) suppressor of cytokine si ( 536) 1160 238.7 2.8e-62
NP_054730 (OMIM: 607094) suppressor of cytokine si ( 536) 1160 238.7 2.8e-62
XP_005266840 (OMIM: 605118) PREDICTED: suppressor  ( 535)  232 56.0 2.7e-07
NP_004223 (OMIM: 605118) suppressor of cytokine si ( 535)  232 56.0 2.7e-07
XP_016881576 (OMIM: 605118) PREDICTED: suppressor  ( 535)  232 56.0 2.7e-07
XP_016881575 (OMIM: 605118) PREDICTED: suppressor  ( 535)  232 56.0 2.7e-07
NP_659508 (OMIM: 602441,607948,611162,614383) cyto ( 258)  207 51.0 4.4e-06
XP_011531631 (OMIM: 602441,607948,611162,614383) P ( 264)  207 51.0 4.5e-06
NP_037456 (OMIM: 602441,607948,611162,614383) cyto ( 275)  207 51.0 4.6e-06
XP_016880041 (OMIM: 608788) PREDICTED: suppressor  ( 576)  195 48.8 4.5e-05
NP_055413 (OMIM: 608788) suppressor of cytokine si ( 581)  195 48.8 4.5e-05
XP_016880040 (OMIM: 608788) PREDICTED: suppressor  ( 611)  195 48.8 4.7e-05
NP_003736 (OMIM: 603597) suppressor of cytokine si ( 211)  184 46.4 8.5e-05
NP_001257398 (OMIM: 605117) suppressor of cytokine ( 198)  159 41.5  0.0024
NP_001257397 (OMIM: 605117) suppressor of cytokine ( 198)  159 41.5  0.0024
NP_001257399 (OMIM: 605117) suppressor of cytokine ( 198)  159 41.5  0.0024
NP_001257396 (OMIM: 605117) suppressor of cytokine ( 198)  159 41.5  0.0024
NP_001257400 (OMIM: 605117) suppressor of cytokine ( 198)  159 41.5  0.0024
NP_003868 (OMIM: 605117) suppressor of cytokine si ( 198)  159 41.5  0.0024
XP_016875645 (OMIM: 605117) PREDICTED: suppressor  ( 198)  159 41.5  0.0024
XP_011537238 (OMIM: 605117) PREDICTED: suppressor  ( 204)  159 41.5  0.0025
XP_011537237 (OMIM: 605117) PREDICTED: suppressor  ( 212)  159 41.5  0.0026
XP_011537231 (OMIM: 605117) PREDICTED: suppressor  ( 220)  159 41.5  0.0027
XP_016875644 (OMIM: 605117) PREDICTED: suppressor  ( 222)  159 41.5  0.0027
XP_016875640 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875642 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875643 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875641 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875636 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875637 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875639 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029
XP_016875638 (OMIM: 605117) PREDICTED: suppressor  ( 243)  159 41.5  0.0029


>>XP_011534727 (OMIM: 616337) PREDICTED: suppressor of c  (440 aa)
 initn: 3048 init1: 3048 opt: 3048  Z-score: 3248.7  bits: 610.3 E(85289): 3.2e-174
Smith-Waterman score: 3048; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440)

               10        20        30        40        50        60
pF1KB8 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
              370       380       390       400       410       420

              430       440
pF1KB8 EYHYKSKVRVLRIDAPEQQC
       ::::::::::::::::::::
XP_011 EYHYKSKVRVLRIDAPEQQC
              430       440

>>XP_011534728 (OMIM: 616337) PREDICTED: suppressor of c  (440 aa)
 initn: 3048 init1: 3048 opt: 3048  Z-score: 3248.7  bits: 610.3 E(85289): 3.2e-174
Smith-Waterman score: 3048; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440)

               10        20        30        40        50        60
pF1KB8 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
              370       380       390       400       410       420

              430       440
pF1KB8 EYHYKSKVRVLRIDAPEQQC
       ::::::::::::::::::::
XP_011 EYHYKSKVRVLRIDAPEQQC
              430       440

>>NP_955453 (OMIM: 616337) suppressor of cytokine signal  (440 aa)
 initn: 3048 init1: 3048 opt: 3048  Z-score: 3248.7  bits: 610.3 E(85289): 3.2e-174
Smith-Waterman score: 3048; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440)

               10        20        30        40        50        60
pF1KB8 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
              370       380       390       400       410       420

              430       440
pF1KB8 EYHYKSKVRVLRIDAPEQQC
       ::::::::::::::::::::
NP_955 EYHYKSKVRVLRIDAPEQQC
              430       440

>>NP_543143 (OMIM: 616337) suppressor of cytokine signal  (440 aa)
 initn: 3048 init1: 3048 opt: 3048  Z-score: 3248.7  bits: 610.3 E(85289): 3.2e-174
Smith-Waterman score: 3048; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440)

               10        20        30        40        50        60
pF1KB8 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
              370       380       390       400       410       420

              430       440
pF1KB8 EYHYKSKVRVLRIDAPEQQC
       ::::::::::::::::::::
NP_543 EYHYKSKVRVLRIDAPEQQC
              430       440

>>NP_659198 (OMIM: 607094) suppressor of cytokine signal  (536 aa)
 initn: 1399 init1: 1035 opt: 1160  Z-score: 1239.1  bits: 238.7 E(85289): 2.8e-62
Smith-Waterman score: 1496; 54.2% identity (77.3% similar) in 437 aa overlap (7-430:93-525)

                                       10          20        30    
pF1KB8                         MAENNENISKNVD--VRPKTSRSRSADRKDGYVWSG
                                     .: :. :  : : :  .:  . .    :.:
NP_659 IALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGG
             70        80        90       100       110       120  

            40        50        60        70        80         90  
pF1KB8 KKL-SWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLG-RSLK
       ::  : : :..:  ::.   :  .:. .:. .::... ::.. :.: : . : .: :::.
NP_659 KKKHSCSTKTQSSLDADKKFG--RTRSGLQRRERRYGVSSVH-DMD-SVSSRTVGSRSLR
            130       140         150       160         170        

            100       110       120       130       140       150  
pF1KB8 QKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTA
       :.:::.:: :::... :.. .  . .:::::.:::::.:::::  :::: .::.::.:::
NP_659 QRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA
      180       190       200       210       220       230        

            160         170          180       190       200       
pF1KB8 PINSKSDEWVSTD--LSQTELRDGQLKRR---NMEENINCFSHTNVQPCVITTD-NALCR
       :.. .:  . . :  : .:: .. .:..:   ..::...   .....    :.. : : .
NP_659 PVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYK
      240       250       260       270       280       290        

        210       220         230       240       250        260   
pF1KB8 EGPMTGSVMNLVSNNS--IEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEI-LQLETPPK
        ::  .  :. .:..:  : ... ::...  ::: .::.... . . :..  .. .   :
NP_659 LGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWK
      300       310       320       330       340       350        

           270       280       290       300       310       320   
pF1KB8 YHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
        ::::::.::::::::::..:::::::::.: ::::::::::::::::::::::::::::
NP_659 VHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS
      360       370       380       390       400       410        

           330       340       350       360       370       380   
pF1KB8 FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIR
       ::::.::::::::::::::::::::::::::  .:::::::::::.::::::::.  : :
NP_659 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNR
      420       430       440       450       460       470        

           390       400       410       420       430       440 
pF1KB8 TFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC 
       :::::::.:::.::: ::::::::.::.:: .. .:::::::.::::           
NP_659 TFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
      480       490       500       510       520       530      

>>NP_054730 (OMIM: 607094) suppressor of cytokine signal  (536 aa)
 initn: 1399 init1: 1035 opt: 1160  Z-score: 1239.1  bits: 238.7 E(85289): 2.8e-62
Smith-Waterman score: 1496; 54.2% identity (77.3% similar) in 437 aa overlap (7-430:93-525)

                                       10          20        30    
pF1KB8                         MAENNENISKNVD--VRPKTSRSRSADRKDGYVWSG
                                     .: :. :  : : :  .:  . .    :.:
NP_054 IALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGG
             70        80        90       100       110       120  

            40        50        60        70        80         90  
pF1KB8 KKL-SWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLG-RSLK
       ::  : : :..:  ::.   :  .:. .:. .::... ::.. :.: : . : .: :::.
NP_054 KKKHSCSTKTQSSLDADKKFG--RTRSGLQRRERRYGVSSVH-DMD-SVSSRTVGSRSLR
            130       140         150       160         170        

            100       110       120       130       140       150  
pF1KB8 QKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTA
       :.:::.:: :::... :.. .  . .:::::.:::::.:::::  :::: .::.::.:::
NP_054 QRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA
      180       190       200       210       220       230        

            160         170          180       190       200       
pF1KB8 PINSKSDEWVSTD--LSQTELRDGQLKRR---NMEENINCFSHTNVQPCVITTD-NALCR
       :.. .:  . . :  : .:: .. .:..:   ..::...   .....    :.. : : .
NP_054 PVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYK
      240       250       260       270       280       290        

        210       220         230       240       250        260   
pF1KB8 EGPMTGSVMNLVSNNS--IEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEI-LQLETPPK
        ::  .  :. .:..:  : ... ::...  ::: .::.... . . :..  .. .   :
NP_054 LGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWK
      300       310       320       330       340       350        

           270       280       290       300       310       320   
pF1KB8 YHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
        ::::::.::::::::::..:::::::::.: ::::::::::::::::::::::::::::
NP_054 VHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS
      360       370       380       390       400       410        

           330       340       350       360       370       380   
pF1KB8 FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIR
       ::::.::::::::::::::::::::::::::  .:::::::::::.::::::::.  : :
NP_054 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNR
      420       430       440       450       460       470        

           390       400       410       420       430       440 
pF1KB8 TFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC 
       :::::::.:::.::: ::::::::.::.:: .. .:::::::.::::           
NP_054 TFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
      480       490       500       510       520       530      

>>XP_005266840 (OMIM: 605118) PREDICTED: suppressor of c  (535 aa)
 initn: 341 init1: 200 opt: 232  Z-score: 252.0  bits: 56.0 E(85289): 2.7e-07
Smith-Waterman score: 319; 36.9% identity (60.7% similar) in 168 aa overlap (271-424:369-535)

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
                                     :  :. .: .. ..  ::: . .. ::. :
XP_005 SMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKL
      340       350       360       370       380       390        

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
        . :.:.::.:::... ::.:.::: ....::.:::. :  :::  ..: :    .:. :
XP_005 ANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDL
      400       410       420       430       440        450       

               370       380                    390       400      
pF1KB8 LEH-YKDPSACMFFEPLLSTPLIRTFPF-------------SLQHICRTVICNCTTYDGI
       .::  .:     :       :   :.:              :::..:: :: . :  : :
XP_005 IEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLI
       460       470       480       490       500       510       

        410       420       430       440
pF1KB8 DALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
       . ::.:..:: ::.: ::                
XP_005 QKLPLPNKMKDYLQEKHY                
       520       530                     

>>NP_004223 (OMIM: 605118) suppressor of cytokine signal  (535 aa)
 initn: 341 init1: 200 opt: 232  Z-score: 252.0  bits: 56.0 E(85289): 2.7e-07
Smith-Waterman score: 319; 36.9% identity (60.7% similar) in 168 aa overlap (271-424:369-535)

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
                                     :  :. .: .. ..  ::: . .. ::. :
NP_004 SMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKL
      340       350       360       370       380       390        

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
        . :.:.::.:::... ::.:.::: ....::.:::. :  :::  ..: :    .:. :
NP_004 ANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDL
      400       410       420       430       440        450       

               370       380                    390       400      
pF1KB8 LEH-YKDPSACMFFEPLLSTPLIRTFPF-------------SLQHICRTVICNCTTYDGI
       .::  .:     :       :   :.:              :::..:: :: . :  : :
NP_004 IEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLI
       460       470       480       490       500       510       

        410       420       430       440
pF1KB8 DALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
       . ::.:..:: ::.: ::                
NP_004 QKLPLPNKMKDYLQEKHY                
       520       530                     

>>XP_016881576 (OMIM: 605118) PREDICTED: suppressor of c  (535 aa)
 initn: 341 init1: 200 opt: 232  Z-score: 252.0  bits: 56.0 E(85289): 2.7e-07
Smith-Waterman score: 319; 36.9% identity (60.7% similar) in 168 aa overlap (271-424:369-535)

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
                                     :  :. .: .. ..  ::: . .. ::. :
XP_016 SMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKL
      340       350       360       370       380       390        

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
        . :.:.::.:::... ::.:.::: ....::.:::. :  :::  ..: :    .:. :
XP_016 ANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDL
      400       410       420       430       440        450       

               370       380                    390       400      
pF1KB8 LEH-YKDPSACMFFEPLLSTPLIRTFPF-------------SLQHICRTVICNCTTYDGI
       .::  .:     :       :   :.:              :::..:: :: . :  : :
XP_016 IEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLI
       460       470       480       490       500       510       

        410       420       430       440
pF1KB8 DALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
       . ::.:..:: ::.: ::                
XP_016 QKLPLPNKMKDYLQEKHY                
       520       530                     

>>XP_016881575 (OMIM: 605118) PREDICTED: suppressor of c  (535 aa)
 initn: 341 init1: 200 opt: 232  Z-score: 252.0  bits: 56.0 E(85289): 2.7e-07
Smith-Waterman score: 319; 36.9% identity (60.7% similar) in 168 aa overlap (271-424:369-535)

              250       260       270       280       290       300
pF1KB8 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
                                     :  :. .: .. ..  ::: . .. ::. :
XP_016 SMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKL
      340       350       360       370       380       390        

              310       320       330       340       350       360
pF1KB8 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
        . :.:.::.:::... ::.:.::: ....::.:::. :  :::  ..: :    .:. :
XP_016 ANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDL
      400       410       420       430       440        450       

               370       380                    390       400      
pF1KB8 LEH-YKDPSACMFFEPLLSTPLIRTFPF-------------SLQHICRTVICNCTTYDGI
       .::  .:     :       :   :.:              :::..:: :: . :  : :
XP_016 IEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLI
       460       470       480       490       500       510       

        410       420       430       440
pF1KB8 DALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
       . ::.:..:: ::.: ::                
XP_016 QKLPLPNKMKDYLQEKHY                
       520       530                     




440 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 15:55:09 2016 done: Fri Nov  4 15:55:11 2016
 Total Scan time:  8.230 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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