Result of FASTA (omim) for pF1KB8220
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8220, 432 aa
  1>>>pF1KB8220 432 - 432 aa - 432 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.0913+/-0.000599; mu= -9.7846+/- 0.037
 mean_var=441.4222+/-90.304, 0's: 0 Z-trim(117.5): 179  B-trim: 339 in 1/55
 Lambda= 0.061045
 statistics sampled from 29340 (29527) to 29340 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.346), width:  16
 Scan time:  9.280

The best scores are:                                      opt bits E(85289)
NP_002046 (OMIM: 137780,203450) glial fibrillary a ( 432) 2701 252.7 1.4e-66
NP_001124491 (OMIM: 137780,203450) glial fibrillar ( 431) 2450 230.6 6.2e-60
XP_016879940 (OMIM: 137780,203450) PREDICTED: glia ( 472) 2450 230.6 6.6e-60
NP_001229305 (OMIM: 137780,203450) glial fibrillar ( 438) 2447 230.3 7.5e-60
XP_006717563 (OMIM: 116300,193060) PREDICTED: vime ( 466) 1608 156.5 1.4e-37
NP_003371 (OMIM: 116300,193060) vimentin [Homo sap ( 466) 1608 156.5 1.4e-37
NP_001918 (OMIM: 125660,181400,601419,602067,60476 ( 470) 1580 154.0 7.6e-37
NP_006253 (OMIM: 105400,170710) peripherin [Homo s ( 470) 1438 141.5 4.4e-33
XP_005269082 (OMIM: 105400,170710) PREDICTED: peri ( 471) 1426 140.4 9.2e-33
NP_116116 (OMIM: 605338) alpha-internexin [Homo sa ( 499) 1097 111.5 5.1e-24
NP_006149 (OMIM: 162280,607684,607734) neurofilame ( 543) 1045 106.9 1.3e-22
NP_005373 (OMIM: 162250) neurofilament medium poly ( 916) 1024 105.3 6.6e-22
XP_011528502 (OMIM: 105400,162230,616924) PREDICTE ( 924)  881 92.7 4.1e-18
NP_066554 (OMIM: 105400,162230,616924) neurofilame (1020)  881 92.8 4.4e-18
NP_001243222 (OMIM: 148060) keratin, type II cytos ( 483)  754 81.3 6.1e-15
NP_002264 (OMIM: 148060) keratin, type II cytoskel ( 483)  754 81.3 6.1e-15
XP_011536627 (OMIM: 148059) PREDICTED: keratin, ty ( 445)  753 81.1 6.2e-15
NP_001243211 (OMIM: 148060) keratin, type II cytos ( 511)  754 81.3 6.4e-15
NP_005547 (OMIM: 148059) keratin, type II cytoskel ( 469)  751 81.0 7.2e-15
NP_004684 (OMIM: 609025,612318) keratin, type II c ( 551)  725 78.8 3.9e-14
NP_000415 (OMIM: 131760,131800,131900,131960,14804 ( 590)  708 77.3 1.2e-13
XP_016874785 (OMIM: 158000,601928) PREDICTED: kera ( 486)  703 76.8 1.4e-13
NP_001307127 (OMIM: 158000,601928) keratin, type I ( 486)  703 76.8 1.4e-13
NP_775109 (OMIM: 612315,615735) keratin, type II c ( 564)  704 76.9 1.4e-13
XP_005268923 (OMIM: 158000,601928) PREDICTED: kera ( 563)  703 76.8 1.5e-13
NP_002273 (OMIM: 158000,602765) keratin, type II c ( 493)  701 76.6 1.6e-13
NP_005546 (OMIM: 148042,615728) keratin, type II c ( 564)  700 76.6 1.8e-13
NP_476429 (OMIM: 122100,148043) keratin, type II c ( 628)  700 76.6   2e-13
NP_149034 (OMIM: 602766) keratin, type II cuticula ( 600)  696 76.3 2.5e-13
XP_011536637 (OMIM: 602766) PREDICTED: keratin, ty ( 600)  696 76.3 2.5e-13
NP_002272 (OMIM: 158000,602153) keratin, type II c ( 505)  692 75.8 2.8e-13
NP_000413 (OMIM: 148069,167210,184500) keratin, ty ( 432)  689 75.5   3e-13
NP_056932 (OMIM: 616671) keratin, type II cytoskel ( 638)  691 75.8 3.5e-13
NP_005545 (OMIM: 148041,615726) keratin, type II c ( 564)  688 75.5 3.8e-13
NP_000517 (OMIM: 125595,131760,131800,131900,14806 ( 472)  686 75.3 3.8e-13
NP_002274 (OMIM: 602032,602767) keratin, type II c ( 507)  685 75.2 4.3e-13
NP_000414 (OMIM: 146800,600194) keratin, type II c ( 639)  687 75.5 4.4e-13
NP_149022 (OMIM: 601078) keratin, type II cuticula ( 513)  681 74.9 5.5e-13
NP_002263 (OMIM: 123940,193900) keratin, type II c ( 520)  676 74.4 7.5e-13
NP_006112 (OMIM: 113800,139350,144200,146590,60096 ( 644)  677 74.6 8.2e-13
XP_016874238 (OMIM: 608245,615896) PREDICTED: kera ( 441)  667 73.6 1.2e-12
NP_778238 (OMIM: 608247) keratin, type II cytoskel ( 540)  669 73.8 1.2e-12
NP_705694 (OMIM: 148065,615785) keratin, type I cy ( 458)  666 73.5 1.3e-12
NP_258259 (OMIM: 608245,615896) keratin, type II c ( 523)  667 73.6 1.3e-12
NP_002266 (OMIM: 148030) keratin, type I cytoskele ( 456)  663 73.2 1.5e-12
NP_002265 (OMIM: 148065,615785) keratin, type I cy ( 420)  656 72.6 2.2e-12
NP_005548 (OMIM: 148067,167200,613000) keratin, ty ( 473)  657 72.7 2.3e-12
NP_778223 (OMIM: 194300,608248,613981,614929) kera ( 529)  658 72.9 2.3e-12
NP_787028 (OMIM: 611160) keratin, type II cytoskel ( 535)  654 72.5 2.9e-12
NP_778253 (OMIM: 611158) keratin, type II cytoskel ( 578)  651 72.3 3.7e-12


>>NP_002046 (OMIM: 137780,203450) glial fibrillary acidi  (432 aa)
 initn: 2701 init1: 2701 opt: 2701  Z-score: 1316.5  bits: 252.7 E(85289): 1.4e-66
Smith-Waterman score: 2701; 100.0% identity (100.0% similar) in 432 aa overlap (1-432:1-432)

               10        20        30        40        50        60
pF1KB8 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 IEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEV
              370       380       390       400       410       420

              430  
pF1KB8 IKESKQEHKDVM
       ::::::::::::
NP_002 IKESKQEHKDVM
              430  

>>NP_001124491 (OMIM: 137780,203450) glial fibrillary ac  (431 aa)
 initn: 2442 init1: 2442 opt: 2450  Z-score: 1197.0  bits: 230.6 E(85289): 6.2e-60
Smith-Waterman score: 2450; 92.4% identity (97.2% similar) in 423 aa overlap (1-421:1-423)

               10        20        30        40        50        60
pF1KB8 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
              310       320       330       340       350       360

              370       380       390         400       410        
pF1KB8 IEIATYRKLLEGEENRITIPVQTFSNLQIR--ETSLDTKSVSEGHLKRNIVVKTVEMRDG
       ::::::::::::::::::::::::::::::  ... : .. .  .  ........ ..  
NP_001 IEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAH
              370       380       390       400       410       420

      420       430  
pF1KB8 EVIKESKQEHKDVM
       ...           
NP_001 QIVNGTPPARG   
              430    

>>XP_016879940 (OMIM: 137780,203450) PREDICTED: glial fi  (472 aa)
 initn: 2442 init1: 2442 opt: 2450  Z-score: 1196.5  bits: 230.6 E(85289): 6.6e-60
Smith-Waterman score: 2556; 91.4% identity (91.4% similar) in 464 aa overlap (1-424:1-464)

               10        20        30        40        50        60
pF1KB8 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
              310       320       330       340       350       360

              370       380       390                              
pF1KB8 IEIATYRKLLEGEENRITIPVQTFSNLQIR------------------------------
       ::::::::::::::::::::::::::::::                              
XP_016 IEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAH
              370       380       390       400       410       420

                        400       410       420       430  
pF1KB8 ----------ETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
                 ::::::::::::::::::::::::::::::::::        
XP_016 QIVNGTPPARETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
              430       440       450       460       470  

>>NP_001229305 (OMIM: 137780,203450) glial fibrillary ac  (438 aa)
 initn: 2442 init1: 2442 opt: 2447  Z-score: 1195.5  bits: 230.3 E(85289): 7.5e-60
Smith-Waterman score: 2447; 97.5% identity (98.5% similar) in 403 aa overlap (1-403:1-401)

               10        20        30        40        50        60
pF1KB8 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 IEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEV
       ::::::::::::::::::::::::::::::  .  ...  :::                 
NP_001 IEIATYRKLLEGEENRITIPVQTFSNLQIR--GQYSRASWEGHWSPAPSSRACRLLQTGT
              370       380       390         400       410        

              430          
pF1KB8 IKESKQEHKDVM        
                           
NP_001 EDQGKGIQLSLGAFVTLQRS
      420       430        

>>XP_006717563 (OMIM: 116300,193060) PREDICTED: vimentin  (466 aa)
 initn: 1693 init1: 1598 opt: 1608  Z-score: 795.8  bits: 156.5 E(85289): 1.4e-37
Smith-Waterman score: 1608; 58.1% identity (85.9% similar) in 427 aa overlap (8-431:47-465)

                                      10        20        30       
pF1KB8                        MERRRITSAARRSYVSSGEMMVGGLAPGRRLG---PG
                                     :..:  :.::   . .  . . ::    ::
XP_006 GPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPG
         20        30        40        50        60        70      

           40        50        60        70        80        90    
pF1KB8 TRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQN
       .::        :   :::::: :.:. ::.::..:..:..:::::::.::.:::::::::
XP_006 VRL--------LQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQN
                 80        90       100       110       120        

          100       110       120       130       140       150    
pF1KB8 KALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQK
       : : :::.::...  ..:.:.:. :.:::: ..:::: ..::.::::::::.:.  .:.:
XP_006 KILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREK
      130       140       150       160       170       180        

          160       170       180       190       200       210    
pF1KB8 LQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQ
       ::.:   : ::::.: ..::..:.:.:::::::::.:::.::: ::.:.::::..::: :
XP_006 LQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQ
      190       200       210       220       230       240        

          220       230       240       250       260       270    
pF1KB8 LARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAEL
       . .:.:....::.::::::::...: :::..:..:..::::::.::::::..:: :: . 
XP_006 IQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDA
      250       260       270       280       290       300        

          280       290       300       310       320       330    
pF1KB8 LRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEE
       :::::.:...::::.:::::....:.::::::::::::.::  . :::.::....::..:
XP_006 LRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDE
      310       320       330       340       350       360        

          340       350       360       370       380       390    
pF1KB8 GQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSL
        :..:.::::::.:::::::::.:::::::::::::::::.::..:. .::.:..:::.:
XP_006 IQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNL
      370       380       390       400       410       420        

          400       410       420       430  
pF1KB8 DTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
       :.  . . : ::....:::: :::.::.:..:.: :. 
XP_006 DSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
      430       440       450       460      

>>NP_003371 (OMIM: 116300,193060) vimentin [Homo sapiens  (466 aa)
 initn: 1693 init1: 1598 opt: 1608  Z-score: 795.8  bits: 156.5 E(85289): 1.4e-37
Smith-Waterman score: 1608; 58.1% identity (85.9% similar) in 427 aa overlap (8-431:47-465)

                                      10        20        30       
pF1KB8                        MERRRITSAARRSYVSSGEMMVGGLAPGRRLG---PG
                                     :..:  :.::   . .  . . ::    ::
NP_003 GPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPG
         20        30        40        50        60        70      

           40        50        60        70        80        90    
pF1KB8 TRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQN
       .::        :   :::::: :.:. ::.::..:..:..:::::::.::.:::::::::
NP_003 VRL--------LQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQN
                 80        90       100       110       120        

          100       110       120       130       140       150    
pF1KB8 KALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQK
       : : :::.::...  ..:.:.:. :.:::: ..:::: ..::.::::::::.:.  .:.:
NP_003 KILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREK
      130       140       150       160       170       180        

          160       170       180       190       200       210    
pF1KB8 LQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQ
       ::.:   : ::::.: ..::..:.:.:::::::::.:::.::: ::.:.::::..::: :
NP_003 LQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQ
      190       200       210       220       230       240        

          220       230       240       250       260       270    
pF1KB8 LARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAEL
       . .:.:....::.::::::::...: :::..:..:..::::::.::::::..:: :: . 
NP_003 IQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDA
      250       260       270       280       290       300        

          280       290       300       310       320       330    
pF1KB8 LRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEE
       :::::.:...::::.:::::....:.::::::::::::.::  . :::.::....::..:
NP_003 LRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDE
      310       320       330       340       350       360        

          340       350       360       370       380       390    
pF1KB8 GQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSL
        :..:.::::::.:::::::::.:::::::::::::::::.::..:. .::.:..:::.:
NP_003 IQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNL
      370       380       390       400       410       420        

          400       410       420       430  
pF1KB8 DTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
       :.  . . : ::....:::: :::.::.:..:.: :. 
NP_003 DSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
      430       440       450       460      

>>NP_001918 (OMIM: 125660,181400,601419,602067,604765,61  (470 aa)
 initn: 1559 init1: 1455 opt: 1580  Z-score: 782.5  bits: 154.0 E(85289): 7.6e-37
Smith-Waterman score: 1580; 58.0% identity (84.1% similar) in 429 aa overlap (7-432:47-470)

                                       10         20        30     
pF1KB8                         MERRRITSAARRSY-VSSGEMMVGGLAPGRRLGPGT
                                     .:.. : : ::     .:::.  :    ..
NP_001 TFGGAPGFPLGSPLSSPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGGLGSLR----AS
         20        30        40        50        60        70      

          40          50        60        70        80        90   
pF1KB8 RLSLARMPPPLPTR--VDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQ
       ::. .: :    .   .::::: :.:  :  ::..:..:..:::::::.:::::::::::
NP_001 RLGTTRTPSSYGAGELLDFSLADAVNQEFLTTRTNEKVELQELNDRFANYIEKVRFLEQQ
             80        90       100       110       120       130  

           100       110       120       130       140       150   
pF1KB8 NKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQ
       : :::::.:.:...:::..:..:. :::::: ... :: . ::..:::::: .::  .. 
NP_001 NAALAAEVNRLKGREPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNLLDDLQRLKA
            140       150       160       170       180       190  

           160       170       180       190       200       210   
pF1KB8 KLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQE
       :::.: .:. ::::::::.: ..: :::::.::::.::::.::: ::.:.::::.:::: 
NP_001 KLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQA
            200       210       220       230       240       250  

           220       230       240       250       260       270   
pF1KB8 QLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAE
       :: .:::.::.:..::::::::..::.:::..:..:. ::::::.:: .:::.:: .: .
NP_001 QLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNND
            260       270       280       290       300       310  

           280       290       300       310       320       330   
pF1KB8 LLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEE
        :::::.:  .::.:.:: ::....:.:::.:: ::::: :.: . ::..::. .:::::
NP_001 ALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEE
            320       330       340       350       360       370  

           340       350       360       370       380       390   
pF1KB8 EGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETS
       : . :::::::::.:::::::::.:::.:::::::::::::.::..:.::.: :..::::
NP_001 EIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTYSALNFRETS
            380       390       400       410       420       430  

           400       410       420       430  
pF1KB8 LDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
        . .. :: : :.....::.: :::::..:. :....:.
NP_001 PEQRG-SEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL
             440       450       460       470

>>NP_006253 (OMIM: 105400,170710) peripherin [Homo sapie  (470 aa)
 initn: 1497 init1: 823 opt: 1438  Z-score: 714.9  bits: 141.5 E(85289): 4.4e-33
Smith-Waterman score: 1438; 56.2% identity (85.1% similar) in 402 aa overlap (30-429:64-459)

                10        20        30        40        50         
pF1KB8  MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALN
                                     : : :   .: :.:     :.:::.: :::
NP_006 YSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAG---ALLRLPS---ERLDFSMAEALN
            40        50        60           70           80       

      60        70        80        90       100       110         
pF1KB8 AGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAE
         :  ::..:. :..:::::::..::::::::::: :: .::.: :..::..  .. : :
NP_006 QEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQE
        90       100       110       120       130       140       

     120       130       140       150       160       170         
pF1KB8 LRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEA
       ::::: .:. :  .  :..::::.::.:::...:.:..::  : .::.::. .:...:.:
NP_006 LRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDA
       150       160       170       180       190       200       

     180       190       200       210       220         230       
pF1KB8 TLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVH-VELDVA-KPDLTAALKE
       ::.::.:::::::: .::.::.:.::::.:.:: ..  :::. ::.... ::.:::::..
NP_006 TLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRD
       210       220       230       240       250       260       

       240       250       260       270       280       290       
pF1KB8 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE
       ::.:::..:..:..::::::.::.:::.::: :: : :::::.: :. :::.:::::...
NP_006 IRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVD
       270       280       290       300       310       320       

       300       310       320       330       340       350       
pF1KB8 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL
       .::::::.: ::.:: ::. . ::..:: . :::::: ..::.::::::.:::.:::::.
NP_006 GLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKM
       330       340       350       360       370       380       

       360       370       380       390       400       410       
pF1KB8 ALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRD
       :::::::::::::::::.::..::..:..:.:. :  ...  ...: ......::.: :.
NP_006 ALDIEIATYRKLLEGEESRISVPVHSFASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRN
       390       400       410       420       430       440       

       420       430          
pF1KB8 GEVIKESKQEHKDVM        
       :::. ::..:..           
NP_006 GEVVTESQKEQRSELDKSSAHSY
       450       460       470

>>XP_005269082 (OMIM: 105400,170710) PREDICTED: peripher  (471 aa)
 initn: 1465 init1: 791 opt: 1426  Z-score: 709.2  bits: 140.4 E(85289): 9.2e-33
Smith-Waterman score: 1426; 56.1% identity (84.9% similar) in 403 aa overlap (30-429:64-460)

                10        20        30        40        50         
pF1KB8  MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALN
                                     : : :   .: :.:     :.:::.: :::
XP_005 YSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAG---ALLRLPS---ERLDFSMAEALN
            40        50        60           70           80       

      60        70        80        90       100       110         
pF1KB8 AGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAE
         :  ::..:. :..:::::::..::::::::::: :: .::.: :..::..  .. : :
XP_005 QEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQE
        90       100       110       120       130       140       

     120       130       140       150       160       170         
pF1KB8 LRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEA
       ::::: .:. :  .  :..::::.::.:::...:.:..::  : .::.::. .:...:.:
XP_005 LRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDA
       150       160       170       180       190       200       

     180       190       200       210       220         230       
pF1KB8 TLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVH-VELDVA-KPDLTAALKE
       ::.::.:::::::: .::.::.:.::::.:.:: ..  :::. ::.... ::.:::::..
XP_005 TLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRD
       210       220       230       240       250       260       

       240       250       260       270       280       290       
pF1KB8 IRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLE
       ::.:::..:..:..::::::.::.:::.::: :: : :::::.: :. :::.:::::...
XP_005 IRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVD
       270       280       290       300       310       320       

       300       310       320       330       340       350       
pF1KB8 SLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKL
       .::::::.: ::.:: ::. . ::..:: . :::::: ..::.::::::.:::.:::::.
XP_005 GLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKM
       330       340       350       360       370       380       

       360       370       380       390       400       410       
pF1KB8 ALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRD
       :::::::::::::::::.::..::..:..:.:. :  ...  ...: ......::.: :.
XP_005 ALDIEIATYRKLLEGEESRISVPVHSFASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRN
       390       400       410       420       430       440       

        420       430          
pF1KB8 GE-VIKESKQEHKDVM        
       :: :. ::..:..           
XP_005 GEQVVTESQKEQRSELDKSSAHSY
       450       460       470 

>>NP_116116 (OMIM: 605338) alpha-internexin [Homo sapien  (499 aa)
 initn: 1108 init1: 631 opt: 1097  Z-score: 552.3  bits: 111.5 E(85289): 5.1e-24
Smith-Waterman score: 1097; 50.3% identity (79.8% similar) in 356 aa overlap (37-387:62-417)

         10        20        30        40        50        60      
pF1KB8 TSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETR
                                     :.::   ::    .:.: :.: .  .:  :
NP_116 AGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKIIR
              40        50        60        70        80        90 

         70        80        90       100         110       120    
pF1KB8 ASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK--EPTKLADVYQAELRELR
       ..:. ... :::::: .::::. :: ::.:: :::  :: .  ::.......: :::.::
NP_116 TNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLR
             100       110       120       130       140       150 

          130       140       150       160       170       180    
pF1KB8 LRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARL
        .:.. ..  ..  .:::.::...  .: . ..:.  :  ::  : : ....: ::::::
NP_116 AQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARL
             160       170       180       190       200       210 

          190       200       210        220         230       240 
pF1KB8 DLERKIESLEEEIRFLRKIHEEEVRELQEQL-ARQQVHVELDV--AKPDLTAALKEIRTQ
       :::.:.::: .:. :.:..:.::: ::   : : .:. .:.::  ::::::.::.:::.:
NP_116 DLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQ
             220       230       240       250       260       270 

             250       260       270       280       290       300 
pF1KB8 YEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRG
       ::..:..:.. :::::.::::.:.. :::..: .: ...: ..::::::. : ..:.:::
NP_116 YESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRG
             280       290       300       310       320       330 

             310       320       330       340       350       360 
pF1KB8 TNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDI
       .:::::::. : ::::  :.:.::.....::.. .. :.::::::.:::::::::.::::
NP_116 ANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDI
             340       350       360       370       380       390 

             370       380       390       400       410       420 
pF1KB8 EIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVI
       :::.:::::::::.:..    ..:.:                                  
NP_116 EIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEE
             400       410       420       430       440       450 




432 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:41:07 2016 done: Fri Nov  4 10:41:09 2016
 Total Scan time:  9.280 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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