Result of FASTA (omim) for pF1KB7721
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7721, 428 aa
  1>>>pF1KB7721 428 - 428 aa - 428 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0630+/-0.000402; mu= 18.5922+/- 0.025
 mean_var=65.5111+/-13.442, 0's: 0 Z-trim(111.0): 105  B-trim: 72 in 1/50
 Lambda= 0.158459
 statistics sampled from 19400 (19511) to 19400 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.229), width:  16
 Scan time:  6.070

The best scores are:                                      opt bits E(85289)
NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 2983 691.1 1.4e-198
NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 1833 428.3 2.1e-119
NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 1833 428.3 2.2e-119
XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 1722 402.9 8.9e-112
XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 1722 402.9 8.9e-112
XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 1672 391.2 1.5e-108
NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1048 248.7 1.8e-65
XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1039 246.7 8.7e-65
XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379)  986 234.6 3.4e-61
XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289)  934 222.6   1e-57
XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274)  829 198.6 1.7e-50
NP_001159890 (OMIM: 300269) histone deacetylase 8  ( 286)  753 181.2   3e-45
XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350)  744 179.2 1.4e-44
NP_001159891 (OMIM: 300269) histone deacetylase 8  ( 256)  725 174.8 2.3e-43
XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268)  493 121.8 2.2e-27
XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389)  458 113.9 7.6e-25
XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324)  449 111.7 2.7e-24
XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415)  449 111.8 3.3e-24
XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315)  331 84.8 3.5e-16
XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341)  322 82.7 1.6e-15
NP_001308806 (OMIM: 606543) histone deacetylase 9  (1025)  322 83.0 3.8e-15
XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025)  322 83.0 3.8e-15
NP_001308826 (OMIM: 606543) histone deacetylase 9  (1025)  322 83.0 3.8e-15
XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035)  322 83.0 3.8e-15
XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038)  322 83.0 3.8e-15
XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038)  322 83.0 3.8e-15
XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043)  322 83.0 3.8e-15
XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043)  322 83.0 3.8e-15
XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043)  322 83.0 3.8e-15
NP_001308797 (OMIM: 606543) histone deacetylase 9  (1044)  322 83.0 3.8e-15
XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044)  322 83.0 3.8e-15
NP_001159892 (OMIM: 300269) histone deacetylase 8  ( 146)  312 80.2 3.8e-15
NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066)  322 83.1 3.9e-15
XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066)  322 83.1 3.9e-15
XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069)  322 83.1 3.9e-15
NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069)  322 83.1 3.9e-15
XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069)  322 83.1 3.9e-15
XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071)  322 83.1 3.9e-15
XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071)  322 83.1 3.9e-15
XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074)  322 83.1 3.9e-15
XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074)  322 83.1 3.9e-15
XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074)  322 83.1 3.9e-15
XP_016879485 (OMIM: 605315) PREDICTED: histone dea (1081)  322 83.1 3.9e-15
XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088)  322 83.1 3.9e-15
XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096)  322 83.1   4e-15
XP_011522452 (OMIM: 605315) PREDICTED: histone dea (1113)  322 83.1   4e-15
XP_016879484 (OMIM: 605315) PREDICTED: histone dea (1113)  322 83.1   4e-15
XP_011522451 (OMIM: 605315) PREDICTED: histone dea (1114)  322 83.1   4e-15
XP_005256962 (OMIM: 605315) PREDICTED: histone dea (1122)  322 83.1   4e-15
XP_005256963 (OMIM: 605315) PREDICTED: histone dea (1122)  322 83.1   4e-15


>>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s  (428 aa)
 initn: 2983 init1: 2983 opt: 2983  Z-score: 3686.1  bits: 691.1 E(85289): 1.4e-198
Smith-Waterman score: 2983; 100.0% identity (100.0% similar) in 428 aa overlap (1-428:1-428)

               10        20        30        40        50        60
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
              370       380       390       400       410       420

               
pF1KB7 DKESDVEI
       ::::::::
NP_003 DKESDVEI
               

>>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s  (482 aa)
 initn: 1130 init1: 977 opt: 1833  Z-score: 2264.6  bits: 428.3 E(85289): 2.1e-119
Smith-Waterman score: 1833; 58.8% identity (84.0% similar) in 425 aa overlap (3-421:9-428)

                     10        20        30        40        50    
pF1KB7       MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQAS
               . : :.:: ::::..:: ::::::::. .::.:.:.::::.:: ...:..:.
NP_004 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
               10        20        30        40        50        60

           60        70        80        90       100       110    
pF1KB7 QHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQG
        ..: ..::.::: ::. . : ::. ..:... ::::.::::: ::::::.  ::.:. .
NP_004 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
               70        80        90       100       110       120

          120       130       140       150       160       170    
pF1KB7 ATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHG
       :..::..  :::.::::::::::: ::::::::::::..:::::::: ::::::::::::
NP_004 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
              130       140       150       160       170       180

          180       190       200       210       220       230    
pF1KB7 DGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKH
       :::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: ::::::::.::. 
NP_004 DGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA
              190       200        210       220       230         

          240       250       260       270       280       290    
pF1KB7 LFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLG
       .:.::...:....::. .:::::.:::. ::::::::.:.::..:::.:::::.:.:.::
NP_004 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG
     240       250       260       270       280       290         

          300       310       320       330       340       350    
pF1KB7 GGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQY
       :::::.:::::::::::.. ..  : .::::..:::::.::: :: . :. . :::. .:
NP_004 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTNEY
     300       310       320       330       340        350        

          360       370       380       390       400              
pF1KB7 LDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPE
       :..:.: .::::.:: :::.::.. .: : .  .  ::   .:  :..  :      :  
NP_004 LEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DEDDPDKRISICSSDKRIA
      360       370       380       390          400       410     

      410       420                                                
pF1KB7 APNEFYDGDHDNDKESDVEI                                        
         .:: :......                                               
NP_004 CEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGV
         420       430       440       450       460       470     

>>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s  (488 aa)
 initn: 1131 init1: 978 opt: 1833  Z-score: 2264.5  bits: 428.3 E(85289): 2.2e-119
Smith-Waterman score: 1833; 58.8% identity (83.8% similar) in 425 aa overlap (3-421:10-429)

                      10        20        30        40        50   
pF1KB7        MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQA
                : : :.:: :.::..:: ::::::::. .::.:.:.::::.:: ...:..:
NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KB7 SQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ
       . ..: ..::..:: ::. . : ::. ..:... ::::.::::: ::::::.  ::.:. 
NP_001 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KB7 GATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHH
       ::..:: .  :.:.::::::::::: ::::::::::::..:::::::: :::::::::::
NP_001 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
              130       140       150       160       170       180

           180       190       200       210       220       230   
pF1KB7 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK
       ::::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: 
NP_001 GDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYG
              190       200        210       220       230         

           240       250       260       270       280       290   
pF1KB7 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL
       ..:.:.:..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:
NP_001 QIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLML
     240       250       260       270       280       290         

           300       310       320       330       340       350   
pF1KB7 GGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQ
       ::::::.:::::::::::.. ..  : .::::..:::::.::: :: . :. . :::. .
NP_001 GGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPE
     300       310       320       330       340       350         

           360       370       380       390       400             
pF1KB7 YLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RP
       :...:.: .::::.:: :::.::.. .: : .  :  :: :.:.  :..  :      : 
NP_001 YMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRI
      360       370       380       390        400         410     

       410       420                                               
pF1KB7 EAPNEFYDGDHDNDKESDVEI                                       
          .:: :.. ...                                              
NP_001 ACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKT
         420       430       440       450       460       470     

>>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety  (458 aa)
 initn: 1020 init1: 867 opt: 1722  Z-score: 2127.7  bits: 402.9 E(85289): 8.9e-112
Smith-Waterman score: 1722; 58.7% identity (83.9% similar) in 404 aa overlap (24-421:1-399)

               10        20        30        40        50        60
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
                              :::::. .::.:.:.::::.:: ...:..:. ..: .
XP_011                        MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTK
                                      10        20        30       

               70        80        90       100       110       120
pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
       .::..:: ::. . : ::. ..:... ::::.::::: ::::::.  ::.:. ::..:: 
XP_011 YHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNR
        40        50        60        70        80        90       

              130       140       150       160       170       180
pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
       .  :.:.::::::::::: ::::::::::::..:::::::: :::::::::::::::.::
XP_011 QQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEA
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
       :: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: ..:.:.:
XP_011 FYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPII
       160       170        180       190       200       210      

              250       260       270       280       290       300
pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
       ..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:::::::.
XP_011 SKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTI
        220       230       240       250       260       270      

              310       320       330       340       350       360
pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
       :::::::::::.. ..  : .::::..:::::.::: :: . :. . :::. .:...:.:
XP_011 RNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPEYMEKIKQ
        280       290       300       310       320        330     

              370       380       390       400             410    
pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPEAPNEFY
        .::::.:: :::.::.. .: : .  :  :: :.:.  :..  :      :    .:: 
XP_011 RLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRIACDEEFS
         340       350       360        370         380       390  

          420                                                      
pF1KB7 DGDHDNDKESDVEI                                              
       :.. ...                                                     
XP_011 DSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKS
            400       410       420       430       440       450  

>>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety  (458 aa)
 initn: 1020 init1: 867 opt: 1722  Z-score: 2127.7  bits: 402.9 E(85289): 8.9e-112
Smith-Waterman score: 1722; 58.7% identity (83.9% similar) in 404 aa overlap (24-421:1-399)

               10        20        30        40        50        60
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
                              :::::. .::.:.:.::::.:: ...:..:. ..: .
XP_016                        MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTK
                                      10        20        30       

               70        80        90       100       110       120
pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
       .::..:: ::. . : ::. ..:... ::::.::::: ::::::.  ::.:. ::..:: 
XP_016 YHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNR
        40        50        60        70        80        90       

              130       140       150       160       170       180
pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
       .  :.:.::::::::::: ::::::::::::..:::::::: :::::::::::::::.::
XP_016 QQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEA
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
       :: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: ..:.:.:
XP_016 FYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPII
       160       170        180       190       200       210      

              250       260       270       280       290       300
pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
       ..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:::::::.
XP_016 SKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTI
        220       230       240       250       260       270      

              310       320       330       340       350       360
pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
       :::::::::::.. ..  : .::::..:::::.::: :: . :. . :::. .:...:.:
XP_016 RNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPEYMEKIKQ
        280       290       300       310       320        330     

              370       380       390       400             410    
pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPEAPNEFY
        .::::.:: :::.::.. .: : .  :  :: :.:.  :..  :      :    .:: 
XP_016 RLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRIACDEEFS
         340       350       360        370         380       390  

          420                                                      
pF1KB7 DGDHDNDKESDVEI                                              
       :.. ...                                                     
XP_016 DSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKS
            400       410       420       430       440       450  

>>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety  (241 aa)
 initn: 1672 init1: 1672 opt: 1672  Z-score: 2070.0  bits: 391.2 E(85289): 1.5e-108
Smith-Waterman score: 1672; 100.0% identity (100.0% similar) in 241 aa overlap (188-428:1-241)

       160       170       180       190       200       210       
pF1KB7 LKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYY
                                     ::::::::::::::::::::::::::::::
XP_011                               MTVSFHKYGNYFFPGTGDMYEVGAESGRYY
                                             10        20        30

       220       230       240       250       260       270       
pF1KB7 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
               40        50        60        70        80        90

       280       290       300       310       320       330       
pF1KB7 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
              100       110       120       130       140       150

       340       350       360       370       380       390       
pF1KB7 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
              160       170       180       190       200       210

       400       410       420        
pF1KB7 RGPEENYSRPEAPNEFYDGDHDNDKESDVEI
       :::::::::::::::::::::::::::::::
XP_011 RGPEENYSRPEAPNEFYDGDHDNDKESDVEI
              220       230       240 

>>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform  (377 aa)
 initn: 1038 init1: 882 opt: 1048  Z-score: 1296.2  bits: 248.7 E(85289): 1.8e-65
Smith-Waterman score: 1048; 43.3% identity (75.1% similar) in 342 aa overlap (26-367:35-374)

                    10        20        30        40        50     
pF1KB7      MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ
                                     :.: ...:::.  :.:.:.: . ::  ::.
NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
           10        20        30        40        50        60    

          60        70        80        90       100       110     
pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA
       ..:  ::.. :.. ::.::  . .    :.. ...: :::.  :.:.. .   ::.. .:
NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
           70        80        90        100       110       120   

         120       130       140       150       160       170     
pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD
         : . .: .::::.:: ::::: :::::::.:: :.:::.: .   :.::.:.:.::::
NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
           130       140       150       160       170       180   

         180       190       200       210       220       230     
pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL
       ::..:: .:..:::::.::..  :::::::. .::  .:::: .:::..:::.:..: ..
NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
           190       200       210       220       230       240   

         240       250       260       270       280       290     
pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG
        . :...: . ..:  .::: :::... : .  ::..  : :.:..:. ....  :.:::
NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
           250       260       270       280       290       300   

         300       310       320       330       340       350     
pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL
       :::.. :.:::::: :.... ...: :.:  :.:  ..::..:.   : :  ..:  . .
NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCR-PDRNEPHRI
           310       320       330       340       350        360  

         360       370       380       390       400       410     
pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD
       .:: . :  :::                                                
NP_060 QQILNYIKGNLKHVV                                             
            370                                                    

>>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety  (441 aa)
 initn: 1017 init1: 882 opt: 1039  Z-score: 1284.1  bits: 246.7 E(85289): 8.7e-65
Smith-Waterman score: 1039; 43.1% identity (75.2% similar) in 339 aa overlap (26-364:73-409)

                    10        20        30        40        50     
pF1KB7      MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ
                                     :.: ...:::.  :.:.:.: . ::  ::.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
             50        60        70        80        90       100  

          60        70        80        90       100       110     
pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA
       ..:  ::.. :.. ::.::  . .    :.. ...: :::.  :.:.. .   ::.. .:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
            110       120       130        140       150       160 

         120       130       140       150       160       170     
pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD
         : . .: .::::.:: ::::: :::::::.:: :.:::.: .   :.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
             170       180       190       200       210       220 

         180       190       200       210       220       230     
pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL
       ::..:: .:..:::::.::..  :::::::. .::  .:::: .:::..:::.:..: ..
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
             230       240       250       260       270       280 

         240       250       260       270       280       290     
pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG
        . :...: . ..:  .::: :::... : .  ::..  : :.:..:. ....  :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
             290       300       310       320       330       340 

         300       310       320       330       340       350     
pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL
       :::.. :.:::::: :.... ...: :.:  :.:  ..::..:.   : :  ..:  . .
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCR-PDRNEPHRI
             350       360       370       380       390        400

         360       370       380       390       400       410     
pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD
       .:: . : :                                                   
XP_011 QQILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV                   
              410       420       430       440                    

>>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety  (379 aa)
 initn: 998 init1: 842 opt: 986  Z-score: 1219.6  bits: 234.6 E(85289): 3.4e-61
Smith-Waterman score: 986; 44.7% identity (76.8% similar) in 302 aa overlap (26-327:73-373)

                    10        20        30        40        50     
pF1KB7      MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ
                                     :.: ...:::.  :.:.:.: . ::  ::.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
             50        60        70        80        90       100  

          60        70        80        90       100       110     
pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA
       ..:  ::.. :.. ::.::  . .    :.. ...: :::.  :.:.. .   ::.. .:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
            110       120       130        140       150       160 

         120       130       140       150       160       170     
pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD
         : . .: .::::.:: ::::: :::::::.:: :.:::.: .   :.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
             170       180       190       200       210       220 

         180       190       200       210       220       230     
pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL
       ::..:: .:..:::::.::..  :::::::. .::  .:::: .:::..:::.:..: ..
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
             230       240       250       260       270       280 

         240       250       260       270       280       290     
pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG
        . :...: . ..:  .::: :::... : .  ::..  : :.:..:. ....  :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
             290       300       310       320       330       340 

         300       310       320       330       340       350     
pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL
       :::.. :.:::::: :.... ...: :.:  :                            
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT                      
             350       360       370                               

         360       370       380       390       400       410     
pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD

>>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety  (289 aa)
 initn: 892 init1: 717 opt: 934  Z-score: 1157.0  bits: 222.6 E(85289): 1e-57
Smith-Waterman score: 934; 54.2% identity (81.2% similar) in 240 aa overlap (188-421:1-235)

       160       170       180       190       200       210       
pF1KB7 LKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYY
                                     :::::::::.:: :::::. ..:: .:.::
XP_011                               MTVSFHKYGEYF-PGTGDLRDIGAGKGKYY
                                             10         20         

       220       230       240       250       260       270       
pF1KB7 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
        .: ::::::::.::. .:.::...:....::. .:::::.:::. ::::::::.:.::.
XP_011 AVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHA
      30        40        50        60        70        80         

       280       290       300       310       320       330       
pF1KB7 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
       .:::.:::::.:.:.:::::::.:::::::::::.. ..  : .::::..:::::.::: 
XP_011 KCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFK
      90       100       110       120       130       140         

       340       350       360       370       380       390       
pF1KB7 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
       :: . :. . :::. .::..:.: .::::.:: :::.::.. .: : .  .  ::   .:
XP_011 LHISPSN-MTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DE
     150        160       170       180       190       200        

       400             410       420                               
pF1KB7 RGPEENYS------RPEAPNEFYDGDHDNDKESDVEI                       
         :..  :      :    .:: :......                              
XP_011 DDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKE
         210       220       230       240       250       260     




428 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 09:15:58 2016 done: Fri Nov  4 09:15:59 2016
 Total Scan time:  6.070 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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