Result of FASTA (omim) for pF1KB7235
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7235, 635 aa
  1>>>pF1KB7235 635 - 635 aa - 635 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.7377+/-0.000341; mu= 12.8203+/- 0.021
 mean_var=112.2315+/-22.266, 0's: 0 Z-trim(118.4): 88  B-trim: 120 in 1/53
 Lambda= 0.121065
 statistics sampled from 31259 (31350) to 31259 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.368), width:  16
 Scan time: 11.200

The best scores are:                                      opt bits E(85289)
NP_005364 (OMIM: 159530,254450,601977,604498) thro ( 635) 4494 796.0       0
XP_016856809 (OMIM: 159530,254450,601977,604498) P ( 692) 4324 766.3       0
NP_000112 (OMIM: 133100,133171) erythropoietin rec ( 508)  262 56.8 2.2e-07
XP_005261397 (OMIM: 138981,614370) PREDICTED: cyto ( 903)  200 46.1 0.00065
NP_000386 (OMIM: 138981,614370) cytokine receptor  ( 897)  186 43.6  0.0035
XP_011544159 (OMIM: 147050,605383,615207) PREDICTE ( 560)  178 42.1  0.0063
NP_851565 (OMIM: 147050,605383,615207) interleukin ( 560)  178 42.1  0.0063
NP_068570 (OMIM: 147050,605383,615207) interleukin ( 538)  174 41.4    0.01
XP_016878746 (OMIM: 147050,605383,615207) PREDICTE ( 538)  174 41.4    0.01
NP_851564 (OMIM: 147050,605383,615207) interleukin ( 538)  174 41.4    0.01


>>NP_005364 (OMIM: 159530,254450,601977,604498) thrombop  (635 aa)
 initn: 4494 init1: 4494 opt: 4494  Z-score: 4246.7  bits: 796.0 E(85289):    0
Smith-Waterman score: 4494; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635)

               10        20        30        40        50        60
pF1KB7 MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB7 TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB7 QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
              550       560       570       580       590       600

              610       620       630     
pF1KB7 TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
       :::::::::::::::::::::::::::::::::::
NP_005 TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
              610       620       630     

>>XP_016856809 (OMIM: 159530,254450,601977,604498) PREDI  (692 aa)
 initn: 4324 init1: 4324 opt: 4324  Z-score: 4085.7  bits: 766.3 E(85289):    0
Smith-Waterman score: 4324; 99.8% identity (99.8% similar) in 611 aa overlap (25-635:82-692)

                     10        20        30        40        50    
pF1KB7       MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDE
                                     : ::::::::::::::::::::::::::::
XP_016 RGGRVRGSPAGPLPFHINMPGRTQGQLTSCSLDVSLLASDSEPLKCFSRTFEDLTCFWDE
              60        70        80        90       100       110 

           60        70        80        90       100       110    
pF1KB7 EEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNV
             120       130       140       150       160       170 

          120       130       140       150       160       170    
pF1KB7 FLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPR
             180       190       200       210       220       230 

          180       190       200       210       220       230    
pF1KB7 DPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASAL
             240       250       260       270       280       290 

          240       250       260       270       280       290    
pF1KB7 TAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTL
             300       310       320       330       340       350 

          300       310       320       330       340       350    
pF1KB7 DLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHF
             360       370       380       390       400       410 

          360       370       380       390       400       410    
pF1KB7 KSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPS
             420       430       440       450       460       470 

          420       430       440       450       460       470    
pF1KB7 SWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPW
             480       490       500       510       520       530 

          480       490       500       510       520       530    
pF1KB7 SSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPD
             540       550       560       570       580       590 

          540       550       560       570       580       590    
pF1KB7 LHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRL
             600       610       620       630       640       650 

          600       610       620       630     
pF1KB7 QPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
       :::::::::::::::::::::::::::::::::::::::::
XP_016 QPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
             660       670       680       690  

>>NP_000112 (OMIM: 133100,133171) erythropoietin recepto  (508 aa)
 initn: 269 init1: 143 opt: 262  Z-score: 253.4  bits: 56.8 E(85289): 2.2e-07
Smith-Waterman score: 265; 25.3% identity (50.9% similar) in 395 aa overlap (249-605:5-382)

      220       230       240       250       260       270        
pF1KB7 QDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTV
                                     : : : :. :    . :.:.  .:. : ..
NP_000                           MDHLGASLWPQVGSL--CLLLAGA--AWAPPPNL
                                         10          20          30

      280                290       300       310       320         
pF1KB7 DLP---GDAVALG------LQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYP
         :   . :. :.      : :::  :....: :..   :.: :    . .     .  :
NP_000 PDPKFESKAALLAARGPEELLCFTERLEDLVCFWEE---AASAGVGPGNYSFSYQLEDEP
               40        50        60           70        80       

     330       340       350        360       370       380        
pF1KB7 IWENCEEEEKTNPGLQTPQFSRCHFKSRN-DSIIHILVEVTTAPGTVHSYLGSPFWIHQA
        :. :. ..   :  .      : . . . .:.. . ..::.: :. . .    . :...
NP_000 -WKLCRLHQA--PTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYH--RVIHINEV
         90         100       110       120       130         140  

      390        400        410        420        430       440    
pF1KB7 VRLPTP-NLHWREIS-SGHLELEW-QHPSSWAAQETCYQLRYT-GEGHQDWKVLEPPLGA
       : : .: .:  :  . :::. :.:   : .  ...  :..  . :.:  . . .:   : 
NP_000 VLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGR
            150       160       170       180       190       200  

           450       460       470       480       490       500   
pF1KB7 RGGTL-ELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLG
          .: .:: :.:: . .:::.  :.. : ::.::.:. . : ..     :. .: :.: 
NP_000 TECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLD--PLILTLSLIL-
            210       220       230       240         250          

           510       520       530                    540          
pF1KB7 LSAVLGLLLLRWQFPAHYRRLRHALWPSLPD----------LHR---VLGQYLRDTAAL-
         .:. .::    . .: : :.. .::..:.           :.    :  :  :     
NP_000 --VVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWW
       260       270       280       290       300       310       

     550              560       570       580         590       600
pF1KB7 SP-------PKATVSDTCEEVEPSLLEILPKSSERTPL--PLCSSQAQMDYRRLQPSCLG
       ::       : :..    :.   ..  . : .... ::  :. : .::  :  :.   : 
NP_000 SPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLP
       320       330       340       350       360       370       

              610       620       630                              
pF1KB7 TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP                         
         : :                                                       
NP_000 RNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLR
       380       390       400       410       420       430       

>>XP_005261397 (OMIM: 138981,614370) PREDICTED: cytokine  (903 aa)
 initn: 115 init1:  74 opt: 200  Z-score: 191.2  bits: 46.1 E(85289): 0.00065
Smith-Waterman score: 210; 22.8% identity (46.8% similar) in 536 aa overlap (36-552:31-503)

          10        20        30        40        50         60    
pF1KB7 LFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFW-DEEEAAPSGTYQ
                                     . :.:..     .:: : : ..:    .  
XP_005 MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVT
               10        20        30        40        50        60

           70          80        90       100       110        120 
pF1KB7 LLYAYPRE--KPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWV-KNVFLNQTRT
       :.    ..  .: .: ::.. ::      .:  :     :  .: . .:  .:   . . 
XP_005 LIRRVNEDLLEPVSCDLSDD-MPW----SACPHPRCVPRRCVIPCQSFVVTDVDYFSFQP
               70        80             90       100       110     

             130       140       150       160       170        180
pF1KB7 QRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYG-PRDPKNST
       .: :     :     .. . .   .: .:::: ..       .: . .  : :..   : 
XP_005 DRPL-----GTRLTVTLTQHVQPPEPRDLQISTDQDHF----LLTWSVALGSPQSHWLSP
              120       130       140           150       160      

              190       200       210       220       230       240
pF1KB7 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
       :   ....  .     ::     .:.  :  .: :.    ::..                
XP_005 GDLEFEVVYKR-----LQDSWEDAAILLSNTSQATL----GPEH----------------
        170            180       190           200                 

              250        260       270        280        290       
pF1KB7 CLISGLQPGNSYWLQLRSE-PDGISLGGSWGSWSLPVTVD-LPGD-AVALGLQCFTLDLK
            :.:...:  ..:..   :  :.:  ..::  :  :  ::: :   .:.::     
XP_005 -----LMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAA
                  210       220       230       240       250      

       300       310          320       330       340          350 
pF1KB7 NVTCQWQQQDHASSQ---GFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQT---PQFSR
        ..:.:. . ...:.   :.::.      :     .     .::. .: :.       .:
XP_005 VLSCSWEVRKEVASSVSFGLFYKPS----PDAGSAV---LLREEECSPVLREGLGSLHTR
        260       270       280              290       300         

              360       370       380       390       400       410
pF1KB7 CHFK-SRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW
        : .    :   :    :.. :  ..... :   :..:   : :.:.  . ....  :.:
XP_005 HHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMA---P-PSLNVTKDGDSY-SLRW
     310       320       330       340           350       360     

               420       430         440       450        460      
pF1KB7 Q-HPSSWAAQETCYQLRYTGEGHQDWK--VLEPPLGARGGTLE-LRPRSRYRLQLRARLN
       .     .   .  ....:  .    ::    :   .:.. .:  :.: .::  ..:.: .
XP_005 ETMKMRYEHIDHTFEIQYRKDT-ATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTS
          370       380        390       400       410       420   

        470       480       490       500       510       520      
pF1KB7 GPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRH
          :.: :: ::.    .:  :..    : :: ...   ::  :: ::.     :: ::.
XP_005 RTGYNGIWSEWSEARSWDT--ESVLPMWVLALIVIFLTIAV--LLALRFCGIYGYR-LRR
           430       440         450       460         470         

        530       540       550       560       570       580      
pF1KB7 ALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQ
           ..:.  .    .   .: : ::                                  
XP_005 KWEEKIPNPSKS-HLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGD
      480       490        500       510       520       530       

>>NP_000386 (OMIM: 138981,614370) cytokine receptor comm  (897 aa)
 initn: 115 init1:  74 opt: 186  Z-score: 178.0  bits: 43.6 E(85289): 0.0035
Smith-Waterman score: 211; 22.4% identity (46.4% similar) in 532 aa overlap (36-552:31-497)

          10        20        30        40        50         60    
pF1KB7 LFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFW-DEEEAAPSGTYQ
                                     . :.:..     .:: : : ..:    .  
NP_000 MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVT
               10        20        30        40        50        60

           70          80        90       100       110        120 
pF1KB7 LLYAYPRE--KPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWV-KNVFLNQTRT
       :.    ..  .: .: ::.. ::      .:  :     :  .: . .:  .:   . . 
NP_000 LIRRVNEDLLEPVSCDLSDD-MPW----SACPHPRCVPRRCVIPCQSFVVTDVDYFSFQP
               70        80             90       100       110     

             130       140       150       160       170        180
pF1KB7 QRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYG-PRDPKNST
       .: :     :     .. . .   .: .:::: ..       .: . .  : :..   : 
NP_000 DRPL-----GTRLTVTLTQHVQPPEPRDLQISTDQDHF----LLTWSVALGSPQSHWLSP
              120       130       140           150       160      

              190       200       210       220       230       240
pF1KB7 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
       :   ....  .     ::     .:.  :  .: :.    ::..                
NP_000 GDLEFEVVYKR-----LQDSWEDAAILLSNTSQATL----GPEH----------------
        170            180       190           200                 

              250        260       270        280        290       
pF1KB7 CLISGLQPGNSYWLQLRSE-PDGISLGGSWGSWSLPVTVD-LPGD-AVALGLQCFTLDLK
            :.:...:  ..:..   :  :.:  ..::  :  :  ::: :   .:.::     
NP_000 -----LMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAA
                  210       220       230       240       250      

       300       310          320       330       340       350    
pF1KB7 NVTCQWQQQDHASSQ---GFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHF
        ..:.:. . ...:.   :.::.       ..  :. ..     .:    : :       
NP_000 VLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPV------
        260       270       280       290       300       310      

          360       370       380       390       400       410    
pF1KB7 KSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQ-HP
           :   :    :.. :  ..... :   :..:   : :.:.  . ....  :.:.   
NP_000 ---PDPATHGQYIVSVQPRRAEKHIKSSVNIQMA---P-PSLNVTKDGDSY-SLRWETMK
                 320       330       340           350        360  

           420       430         440       450        460       470
pF1KB7 SSWAAQETCYQLRYTGEGHQDWK--VLEPPLGARGGTLE-LRPRSRYRLQLRARLNGPTY
         .   .  ....:  .    ::    :   .:.. .:  :.: .::  ..:.: .   :
NP_000 MRYEHIDHTFEIQYRKDT-ATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGY
            370       380        390       400       410       420 

              480       490       500       510       520       530
pF1KB7 QGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWP
       .: :: ::.    .:  :..    : :: ...   ::  :: ::.     :: ::.    
NP_000 NGIWSEWSEARSWDT--ESVLPMWVLALIVIFLTIAV--LLALRFCGIYGYR-LRRKWEE
             430         440       450         460        470      

              540       550       560       570       580       590
pF1KB7 SLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMD
       ..:.  .    .   .: : ::                                      
NP_000 KIPNPSKS-HLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVS
        480        490       500       510       520       530     

>>XP_011544159 (OMIM: 147050,605383,615207) PREDICTED: i  (560 aa)
 initn: 128 init1:  98 opt: 178  Z-score: 173.5  bits: 42.1 E(85289): 0.0063
Smith-Waterman score: 236; 25.1% identity (51.4% similar) in 350 aa overlap (260-579:18-347)

     230       240       250       260       270       280         
pF1KB7 EASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGL
                                     : :.:.  .:..  :   . : :      :
XP_011              MSCRCIFLMKHGERVGWPVGVSMPRGWAAPLL--LLLLQGGWGCPDL
                            10        20        30          40     

     290       300        310       320       330       340        
pF1KB7 QCFTLDLKNVTCQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQ
        :.:  :..: :  .. . : :.  . .... .   .:.     .:  ..... .  :  
XP_011 VCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNA--THA
          50        60        70        80            90           

      350          360       370       380       390       400     
pF1KB7 FSRCH---FKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGH
          ::   :.   :.:.   :..:   :.  .  :: : . .... :.: ..     ::.
XP_011 TYTCHMDVFHFMADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQ
     100       110         120       130        140        150     

         410            420       430       440               450  
pF1KB7 LELEW----QHPSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELR
        .. :    . :. .  . .  :.:.: ..: . : :  :      . .:. .:   :.:
XP_011 YNISWRSDYEDPAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFR
         160       170       180        190        200       210   

            460        470       480          490       500        
pF1KB7 PRSRYRLQLRAR-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVL
         : :.::.::  . : .::: :: ::::.  .: .:    .:       ::.: :  :.
XP_011 KDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVI
           220       230       240       250            260        

      510       520          530            540        550         
pF1KB7 GLLLLRWQFPAH-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDT
        ..   :.. .:   :: . .:  ::     .:  .   :.. . ..: ..  .  ..  
XP_011 VFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPW
      270       280       290       300       310       320        

     560       570       580       590       600       610         
pF1KB7 CEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTT
         :: :: ::.      :.:                                        
XP_011 SPEV-PSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSE
      330        340       350       360       370       380       

>>NP_851565 (OMIM: 147050,605383,615207) interleukin-21   (560 aa)
 initn: 128 init1:  98 opt: 178  Z-score: 173.5  bits: 42.1 E(85289): 0.0063
Smith-Waterman score: 236; 25.1% identity (51.4% similar) in 350 aa overlap (260-579:18-347)

     230       240       250       260       270       280         
pF1KB7 EASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGL
                                     : :.:.  .:..  :   . : :      :
NP_851              MSCRCIFLMKHGERVGWPVGVSMPRGWAAPLL--LLLLQGGWGCPDL
                            10        20        30          40     

     290       300        310       320       330       340        
pF1KB7 QCFTLDLKNVTCQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQ
        :.:  :..: :  .. . : :.  . .... .   .:.     .:  ..... .  :  
NP_851 VCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNA--THA
          50        60        70        80            90           

      350          360       370       380       390       400     
pF1KB7 FSRCH---FKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGH
          ::   :.   :.:.   :..:   :.  .  :: : . .... :.: ..     ::.
NP_851 TYTCHMDVFHFMADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQ
     100       110         120       130        140        150     

         410            420       430       440               450  
pF1KB7 LELEW----QHPSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELR
        .. :    . :. .  . .  :.:.: ..: . : :  :      . .:. .:   :.:
NP_851 YNISWRSDYEDPAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFR
         160       170       180        190        200       210   

            460        470       480          490       500        
pF1KB7 PRSRYRLQLRAR-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVL
         : :.::.::  . : .::: :: ::::.  .: .:    .:       ::.: :  :.
NP_851 KDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVI
           220       230       240       250            260        

      510       520          530            540        550         
pF1KB7 GLLLLRWQFPAH-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDT
        ..   :.. .:   :: . .:  ::     .:  .   :.. . ..: ..  .  ..  
NP_851 VFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPW
      270       280       290       300       310       320        

     560       570       580       590       600       610         
pF1KB7 CEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTT
         :: :: ::.      :.:                                        
NP_851 SPEV-PSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSE
      330        340       350       360       370       380       

>>NP_068570 (OMIM: 147050,605383,615207) interleukin-21   (538 aa)
 initn: 128 init1:  98 opt: 174  Z-score: 170.0  bits: 41.4 E(85289): 0.01
Smith-Waterman score: 228; 24.8% identity (51.6% similar) in 339 aa overlap (272-579:5-325)

             250       260       270       280        290       300
pF1KB7 LISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL-PGDAVALGLQCFTLDLKNVT
                                     :. :. . :  :      : :.:  :..: 
NP_068                           MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVI
                                         10        20        30    

               310       320       330       340       350         
pF1KB7 CQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH---FKS
       :  .. . : :.  . .... .   .:.     .:  ..... . ..     ::   :. 
NP_068 CILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNATHATY--TCHMDVFHF
           40        50         60           70          80        

        360       370       380       390       400       410      
pF1KB7 RNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW----QH
         :.:.   :..:   :.  .  :: : . .... :.: ..     ::. .. :    . 
NP_068 MADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQYNISWRSDYED
       90         100       110         120       130       140    

             420       430       440               450       460   
pF1KB7 PSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELRPRSRYRLQLRA
       :. .  . .  :.:.: ..: . : :  :      . .:. .:   :.:  : :.::.::
NP_068 PAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRA
          150       160         170       180       190       200  

            470       480          490       500       510         
pF1KB7 R-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVLGLLLLRWQFPA
         . : .::: :: ::::.  .: .:    .:       ::.: :  :. ..   :.. .
NP_068 GPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVIVFIPAFWSLKT
            210       220       230            240       250       

     520          530            540        550       560       570
pF1KB7 H-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDTCEEVEPSLLEI
       :   :: . .:  ::     .:  .   :.. . ..: ..  .  ..    :: :: ::.
NP_068 HPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEV-PSTLEV
       260       270       280       290       300       310       

              580       590       600       610       620       630
pF1KB7 LPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLS
             :.:                                                   
NP_068 YSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI
        320       330       340       350       360       370      

>>XP_016878746 (OMIM: 147050,605383,615207) PREDICTED: i  (538 aa)
 initn: 128 init1:  98 opt: 174  Z-score: 170.0  bits: 41.4 E(85289): 0.01
Smith-Waterman score: 228; 24.8% identity (51.6% similar) in 339 aa overlap (272-579:5-325)

             250       260       270       280        290       300
pF1KB7 LISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL-PGDAVALGLQCFTLDLKNVT
                                     :. :. . :  :      : :.:  :..: 
XP_016                           MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVI
                                         10        20        30    

               310       320       330       340       350         
pF1KB7 CQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH---FKS
       :  .. . : :.  . .... .   .:.     .:  ..... . ..     ::   :. 
XP_016 CILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNATHATY--TCHMDVFHF
           40        50         60           70          80        

        360       370       380       390       400       410      
pF1KB7 RNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW----QH
         :.:.   :..:   :.  .  :: : . .... :.: ..     ::. .. :    . 
XP_016 MADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQYNISWRSDYED
       90         100       110         120       130       140    

             420       430       440               450       460   
pF1KB7 PSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELRPRSRYRLQLRA
       :. .  . .  :.:.: ..: . : :  :      . .:. .:   :.:  : :.::.::
XP_016 PAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRA
          150       160         170       180       190       200  

            470       480          490       500       510         
pF1KB7 R-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVLGLLLLRWQFPA
         . : .::: :: ::::.  .: .:    .:       ::.: :  :. ..   :.. .
XP_016 GPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVIVFIPAFWSLKT
            210       220       230            240       250       

     520          530            540        550       560       570
pF1KB7 H-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDTCEEVEPSLLEI
       :   :: . .:  ::     .:  .   :.. . ..: ..  .  ..    :: :: ::.
XP_016 HPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEV-PSTLEV
       260       270       280       290       300       310       

              580       590       600       610       620       630
pF1KB7 LPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLS
             :.:                                                   
XP_016 YSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI
        320       330       340       350       360       370      

>>NP_851564 (OMIM: 147050,605383,615207) interleukin-21   (538 aa)
 initn: 128 init1:  98 opt: 174  Z-score: 170.0  bits: 41.4 E(85289): 0.01
Smith-Waterman score: 228; 24.8% identity (51.6% similar) in 339 aa overlap (272-579:5-325)

             250       260       270       280        290       300
pF1KB7 LISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL-PGDAVALGLQCFTLDLKNVT
                                     :. :. . :  :      : :.:  :..: 
NP_851                           MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVI
                                         10        20        30    

               310       320       330       340       350         
pF1KB7 CQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH---FKS
       :  .. . : :.  . .... .   .:.     .:  ..... . ..     ::   :. 
NP_851 CILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNATHATY--TCHMDVFHF
           40        50         60           70          80        

        360       370       380       390       400       410      
pF1KB7 RNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW----QH
         :.:.   :..:   :.  .  :: : . .... :.: ..     ::. .. :    . 
NP_851 MADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQYNISWRSDYED
       90         100       110         120       130       140    

             420       430       440               450       460   
pF1KB7 PSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELRPRSRYRLQLRA
       :. .  . .  :.:.: ..: . : :  :      . .:. .:   :.:  : :.::.::
NP_851 PAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRA
          150       160         170       180       190       200  

            470       480          490       500       510         
pF1KB7 R-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVLGLLLLRWQFPA
         . : .::: :: ::::.  .: .:    .:       ::.: :  :. ..   :.. .
NP_851 GPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVIVFIPAFWSLKT
            210       220       230            240       250       

     520          530            540        550       560       570
pF1KB7 H-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDTCEEVEPSLLEI
       :   :: . .:  ::     .:  .   :.. . ..: ..  .  ..    :: :: ::.
NP_851 HPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEV-PSTLEV
       260       270       280       290       300       310       

              580       590       600       610       620       630
pF1KB7 LPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLS
             :.:                                                   
NP_851 YSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI
        320       330       340       350       360       370      




635 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 06:10:41 2016 done: Fri Nov  4 06:10:42 2016
 Total Scan time: 11.200 Total Display time:  0.090

Function used was FASTA [36.3.4 Apr, 2011]
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