Result of FASTA (omim) for pF1KA1816
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA1816, 1133 aa
  1>>>pF1KA1816 1133 - 1133 aa - 1133 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 14.3714+/-0.000451; mu= -19.5655+/- 0.028
 mean_var=553.5752+/-115.732, 0's: 0 Z-trim(123.6): 190  B-trim: 74 in 1/55
 Lambda= 0.054511
 statistics sampled from 43556 (43773) to 43556 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.513), width:  16
 Scan time: 14.520

The best scores are:                                      opt bits E(85289)
NP_061187 (OMIM: 608991) mastermind-like protein 3 (1133) 7696 620.9 1.3e-176
NP_055572 (OMIM: 605424) mastermind-like protein 1 (1016)  959 91.1 3.8e-17
NP_115803 (OMIM: 607537) mastermind-like protein 2 (1156)  651 66.9 8.2e-10
XP_011541327 (OMIM: 607537) PREDICTED: mastermind- ( 735)  624 64.6 2.5e-09
XP_016883233 (OMIM: 605299) PREDICTED: nuclear rec (2051)  492 54.6 7.5e-06
XP_011541326 (OMIM: 607537) PREDICTED: mastermind- ( 928)  479 53.3 8.2e-06
XP_011527029 (OMIM: 605299) PREDICTED: nuclear rec (2056)  490 54.4 8.4e-06
XP_011541325 (OMIM: 607537) PREDICTED: mastermind- (1009)  479 53.3 8.7e-06
XP_011527028 (OMIM: 605299) PREDICTED: nuclear rec (2057)  486 54.1   1e-05
XP_016883239 (OMIM: 605299) PREDICTED: nuclear rec (1094)  443 50.5 6.6e-05
XP_016883238 (OMIM: 605299) PREDICTED: nuclear rec (1650)  443 50.6 9.1e-05
XP_016883237 (OMIM: 605299) PREDICTED: nuclear rec (1651)  443 50.6 9.1e-05
XP_016883231 (OMIM: 605299) PREDICTED: nuclear rec (2082)  445 50.9 9.8e-05
XP_016883235 (OMIM: 605299) PREDICTED: nuclear rec (1999)  443 50.7 0.00011
XP_016883232 (OMIM: 605299) PREDICTED: nuclear rec (2058)  443 50.7 0.00011
XP_016883230 (OMIM: 605299) PREDICTED: nuclear rec (2086)  443 50.7 0.00011
XP_016883228 (OMIM: 605299) PREDICTED: nuclear rec (2087)  443 50.7 0.00011
XP_016883229 (OMIM: 605299) PREDICTED: nuclear rec (2087)  443 50.7 0.00011
XP_016883236 (OMIM: 605299) PREDICTED: nuclear rec (1907)  435 50.0 0.00016
XP_016883234 (OMIM: 605299) PREDICTED: nuclear rec (2039)  409 48.0 0.00069
NP_001229468 (OMIM: 605299) nuclear receptor coact (1070)  395 46.7 0.00089
XP_016883240 (OMIM: 605299) PREDICTED: nuclear rec (1070)  395 46.7 0.00089
XP_006723818 (OMIM: 605299) PREDICTED: nuclear rec (1975)  395 46.9  0.0014
NP_001305169 (OMIM: 605299) nuclear receptor coact (2063)  395 46.9  0.0015
NP_054790 (OMIM: 605299) nuclear receptor coactiva (2063)  395 46.9  0.0015
XP_011527023 (OMIM: 605299) PREDICTED: nuclear rec (2068)  393 46.8  0.0017
XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525)  381 46.1  0.0069
XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536)  381 46.1  0.0069
XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537)  381 46.1  0.0069
NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537)  381 46.1  0.0069
XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540)  381 46.1  0.0069
XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549)  381 46.1  0.0069
XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552)  381 46.1  0.0069
XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553)  381 46.1  0.0069
XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555)  381 46.1  0.0069
XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556)  381 46.1  0.0069


>>NP_061187 (OMIM: 608991) mastermind-like protein 3 [Ho  (1133 aa)
 initn: 7696 init1: 7696 opt: 7696  Z-score: 3291.5  bits: 620.9 E(85289): 1.3e-176
Smith-Waterman score: 7696; 99.9% identity (99.9% similar) in 1133 aa overlap (1-1133:1-1133)

               10        20        30        40        50        60
pF1KA1 MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 GGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 GGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 RAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 CDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 CDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 EDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 DINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 DINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 PSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 PSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 PNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 PNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 LMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 QAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA1 EDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA1 AGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILAEQQLQQSHLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 AGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILAEQQLQQSHLP
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA1 RQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA1 TMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 TMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPAS
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA1 GQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 GQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQ
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA1 RSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAA
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA1 MGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQHPAQQQIPSGSFAPSSQSQAYE
       :::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
NP_061 MGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130   
pF1KA1 RNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP
       :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP
             1090      1100      1110      1120      1130   

>>NP_055572 (OMIM: 605424) mastermind-like protein 1 [Ho  (1016 aa)
 initn: 1055 init1: 366 opt: 959  Z-score: 428.8  bits: 91.1 E(85289): 3.8e-17
Smith-Waterman score: 1895; 35.5% identity (64.3% similar) in 1102 aa overlap (66-1132:12-1015)

          40        50        60        70        80        90     
pF1KA1 TPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRY
                                     :.:.::.:.::::.::: ::::: .:: ::
NP_055                    MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARY
                                  10        20        30        40 

         100       110       120           130       140       150 
pF1KA1 QQAQVEQLELERRDTVSLYQRTLEQRAKKSGAG----TGKQQHPSKPQQDAEAASAEQRN
       . .. :.:::::. : .:.:: .. .::..:      ..    :. :    .::.. ...
NP_055 EAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHG
              50        60        70        80        90       100 

             160       170       180       190       200       210 
pF1KA1 HTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMP
       .    :..::::.:..: :: :::::::   :.. :  :. :..   :. ::    :.  
NP_055 RPATHLHDTVKRNLDSATSPQNGDQQNGY--GDLFPGHKKTRREAPLGV-AI----SSNG
             110       120       130         140        150        

             220         230       240       250       260         
pF1KA1 LPSASPLHQLDLKPSLP--LQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTIL
       :: :::: : : :::    ::.:: :. :: ..:.:. :: . .: .:: :.  .:: . 
NP_055 LPPASPLGQSD-KPSGADALQSSGKHSLGL-DSLNKK-RLADSSLHLNGGSNPSESFPLS
          160        170       180         190       200       210 

     270       280       290       300       310       320         
pF1KA1 QSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLF
        .:.:::::..:  :. :. ..  .:..:. :.:::.:::.:::.::  .::..:..:::
NP_055 LNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLF
             220       230       240       250       260       270 

     330       340       350       360       370       380         
pF1KA1 NEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPF---S
       ::::::::.:: :  ::.:::.:.  ..:.. : . : . ..::::.: .:.:  :   :
NP_055 NEDFEEKKDPESSGSATQTPLAQD-INIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPS
             280       290        300       310       320       330

        390       400       410       420         430       440    
pF1KA1 TVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPN--QAHTPGQAPPRPGNGYLLNPAA
       .. ..:. ::.... .  . ...:    ...: .::   : . .:   :   : .: :. 
NP_055 SAPVSTDSPSLGGSQTLFHTSGQP---RADNP-SPNLMPASAQAQNAQRALAGVVL-PS-
              340       350           360       370       380      

          450       460       470       480       490       500    
pF1KA1 VTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQ
              .:: .  .:..: :.::.:.::.:..               .:. :. ::   
NP_055 -------QGPGG--ASELSSAHQLQQIAAKQKR---------------EQMLQNPQQATP
                   390       400                      410       420

          510       520       530       540       550       560    
pF1KA1 QQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNN
           .: :.:.  ::  :   . .  ::: ::  : : :.:.. .. : .:. .    . 
NP_055 APAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGP
              430       440       450       460       470       480

          570        580       590       600       610       620   
pF1KA1 YLPQNHMNMINQQP-NNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNP
       ::  .:.:....:: .::. :: :.: ..: :::::::.:..:: .:    : .. .:  
NP_055 YLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQ--GSPGSGQSKPA
              490       500       510       520         530        

           630       640       650       660       670       680   
pF1KA1 LMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAA
       :: :. ::                         .:.:..:. :.::: :   :.:  . .
NP_055 LMAYLPQQL------------------------SHISHEQNSLFLMKPKP-GNMP--FRS
      540                               550       560          570 

           690        700       710       720       730         740
pF1KA1 LPSHGQEQHPVGLP-RTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQ--MLI
       :   ::::.: ..: .. .   .. ::. .  :...  ..: .:.:: :::.:::  .:.
NP_055 LVPPGQEQNPSSVPVQAQATSVGTQPPAVS--VASSHNSSP-YLSSQQQAAVMKQHQLLL
             580       590       600         610        620        

              750       760       770            780       790     
pF1KA1 DQRAQLIEQQKQQFLREQRQQQQQQQQILAEQQLQQ--SHL---PRQHLQPQRNPYPVQQ
       ::. :  ..:.:. : .:.:  :.::..::::. ::   ::   : :. .: .. .: ::
NP_055 DQQKQ--REQQQKHL-QQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFP-QQ
      630         640        650       660       670       680     

         800       810       820         830        840       850  
pF1KA1 VNQFQGSPQDIAAVRSQAALQSMRTS--RLMAQNAGMMGIGPSQNP-GTMATAAAQSEMG
       :.:: ::    ::: .. .:    .:  :.. : ...: .::..   ... : ..:.. :
NP_055 VGQFTGSS---AAVPGMNTLGPSNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRG
          690          700       710       720       730       740 

            860        870       880       890       900       910 
pF1KA1 LAPYSTTPT-SQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFG
       .: .  . .  : ..:.:..:.::.. .:  ..   :...:. :::   ::.... ...:
NP_055 VAQFPGSQNMPQSSLYGMASGITQIVAQPPPQA---TNGHAHIPRQTNVGQNTSVSAAYG
             750       760       770          780       790        

             920       930       940       950       960       970 
pF1KA1 QSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTS
       :. : .:...:::   :: .. .: .: .: :..  ::   :.. :::.... .. :.: 
NP_055 QNSLGSSGLSQQH--NKGTLNPGLTKPPVP-RVSPAMG--GQNS-SWQHQGMPNLSGQTP
      800       810         820        830          840       850  

               980       990      1000      1010      1020         
pF1KA1 GE--LGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSL
       :.  ..::. ..:. .:  :    :.  :: .::.:   :   .   . ::.: ...: .
NP_055 GNSNVSPFTAASSFHMQ--QQAHLKMSSPQ-FSQAV--PNRPMAPMSSAAAVG-SLLPPV
            860         870       880          890       900       

    1030      1040              1050      1060      1070      1080 
pF1KA1 PGQQGTSQARPMV--------MSGLSQGVPGMPAFSQHPAQQQIPSGSFAPSSQSQAYE-
        .:: ::   :          . ::: . : . :::: ::.:.   :. :    .:::  
NP_055 SAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQM---GGRAGLHCTQAYPV
        910       920       930       940          950       960   

             1090      1100      1110      1120      1130   
pF1KA1 RNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP
       :.: :.. . :::. .:... ..   .::.::..:.  ..:::..::.:.:. 
NP_055 RTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRTSEEWMSDLDDLLGSQ
           970       980       990      1000      1010      

>>NP_115803 (OMIM: 607537) mastermind-like protein 2 [Ho  (1156 aa)
 initn: 1453 init1: 223 opt: 651  Z-score: 297.1  bits: 66.9 E(85289): 8.2e-10
Smith-Waterman score: 1079; 28.2% identity (52.8% similar) in 1235 aa overlap (41-1103:7-1122)

               20        30        40        50        60          
pF1KA1 ANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPG--GGSAAVP
                                     : ::      ::: ::..: :  ::....:
NP_115                         MGDTAPPQAP------AGGLGGASGAGLLGGGSVTP
                                       10              20        30

        70        80        90       100       110        120      
pF1KA1 K-HSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLE-QRAKKSG
       . ::..::::: ::  ::.::..::.::.....:. . ::..:..: . . . : :.:.:
NP_115 RVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAG
               40        50        60        70        80        90

        130                                                        
pF1KA1 AGTG---------------------------------------KQQH------------P
         :                                        .:::             
NP_115 KHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGI
              100       110       120       130       140       150

         140       150       160       170       180       190     
pF1KA1 SKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIR--
       .  ::   .. ..::: .:: :: ..:::     :: :. . ::  :..:    ::::  
NP_115 NGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDI-KRIRVG
              160       170       180       190       200          

           200         210       220       230       240       250 
pF1KA1 KDISAGMEA--INNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPE
       ...:::. .  :::  :.. . .. :. :  :. .  :  : ::.::  . : . : : :
NP_115 ENLSAGQGGLQINNGQSQI-MSGTLPMSQAPLRKTNTLP-SHTHSPG--NGLFNMG-LKE
     210       220        230       240        250         260     

                260       270       280         290       300      
pF1KA1 IKLPVN---GCSDLEDSFTILQSKDLKQEPLDDP--TCIDTSETSLSNQNKLFSDINLND
       .:   .   .::   :.  . : . . ..  :::    .:     : :.   .:   ..:
NP_115 VKKEPGETLSCSKHMDG-QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSD
          270       280        290       300       310       320   

        310       320       330       340        350       360     
pF1KA1 QEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETP-LSQESASVKSDPSHSP
        : ...:.    :. .::    :: :. ..     :: .:  : : .:.  .::.  .::
NP_115 LELENMIN---ATIKQDDP---FNIDLGQQ-----SQRSTPRPSLPMEKIVIKSE--YSP
           330             340            350       360         370

          370       380       390       400       410       420    
pF1KA1 -FAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQA
        ...   :::: :: :.:: :: ...: :             .:::       :..:.. 
NP_115 GLTQGPSGSPQLRPPSAGPAFSMANSALS-------------TSSPI------PSVPQS-
              380       390                    400             410 

          430       440       450        460       470       480   
pF1KA1 HTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPS-SDMSPAEQLKQMAAQQQQRAKLMQ
           :: :. :.:             ::   :.:: ...: :.::::.::..::.:..  
NP_115 ----QAQPQTGSG-------------ASR--ALPSWQEVSHAQQLKQIAANRQQHARM--
                               420         430       440           

           490       500       510       520       530       540   
pF1KA1 QKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAF
                        ::.::::  : .::: :   ..:  . :  ::  :: .  :.:
NP_115 -----------------QQHQQQH--QPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTF
                      450         460       470       480       490

           550        560              570        580       590    
pF1KA1 NNQNPIVPPMANNL-QKTTMNNYL----PQ---NHMNMINQQ-PNNLGTNSLNKQHNILT
       . :.  .: .:..  :. .: ::.    :.   .:.... :: :..:. . .:. :  . 
NP_115 SPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAME
              500       510       520       530       540       550

            600       610        620       630       640       650 
pF1KA1 --YGNTKPLTHFNADLSQRMTPPV-ANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQ
          :::::: :::.: .... : :  . ::  :. : ::::::::::::::::::    :
NP_115 PRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQ
              560       570       580       590       600       610

                       660           670       680       690       
pF1KA1 LQAPR----------AHLSEDQKRLL----LMKQKGVMNQPMAYAALPSHGQEQHPVGLP
        :  .          :. ...:.  .     ..:.  ..: .      .. :.:.: . :
NP_115 QQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQP
              620       630       640       650       660       670

       700                        710                        720   
pF1KA1 RTTGPMQ----SSVP-------------PGSG-----------------GMVSGASPA--
         . : :    : .:             : .:                 :. .: ::.  
NP_115 AQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPN
              680       690       700       710       720       730

                    730       740       750       760       770    
pF1KA1 -------GPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILA--EQ
              : :...::   ....:.:. ..  :   :.:  . ::.::   :::.::  :.
NP_115 PCSNPNTGSGYMNSQQ--SLLNQQLMGKKQTL---QRQ--IMEQKQQLLLQQQMLADAEK
              740         750       760            770       780   

            780              790       800       810       820     
pF1KA1 QLQQSHLPRQHLQP-------QRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMA
          :... :.  .:       .::   .: . :..:. . :.   .::  . . :  ...
NP_115 IAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILT
           790       800       810       820       830       840   

         830       840       850       860       870       880     
pF1KA1 QNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGM
        :..... . .    ...::.  ..::.  :.. : .::. :....::.:. :. : . .
NP_115 PNSSLLSTSHGTRMPSLSTAV--QNMGM--YGNLPCNQPNTYSVTSGMNQLTQQRNPKQL
           850       860           870       880       890         

         890       900        910       920       930       940    
pF1KA1 SITHNQAQGPRQPASG-QGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRL
         ..:. . :: :. : .. . :. :: . . ::   : .:..   .. ..:    : : 
NP_115 LANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQ--QLRPNLTHSMA-SMP----PQRT
     900       910       920       930         940            950  

          950       960          970       980        990          
pF1KA1 QSLMGTVQQGAQSWQQR---SLQGMPGRTSGELGPFNNGASY-PLQAGQPRLTKQHFPQ-
       ...: : .  : .: ..   : :     ..:   : .. :.: : :. :  . .:.: : 
NP_115 SNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQR
            960       970       980       990      1000      1010  

                      1000      1010        1020      1030         
pF1KA1 ------------------GLSQSVVDANTGTVRTLN--PAAMGRQMMPSLPGQQGTSQAR
                          .::..   . : .: ::  :  .. :..:.: .:.::    
NP_115 AVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNL-NQSGT----
           1020      1030      1040      1050      1060            

    1040      1050      1060      1070      1080       1090        
pF1KA1 PMVMSGLSQGVPGMPAFSQHPAQQQIPSGSFAPSSQSQAYE-RNAPQDVSYNYSGDGAGG
            ::.:.  :.   .: :.    ::.  .:...:.:..  .  .:..... ..   .
NP_115 -----GLNQSRTGI---NQPPSLT--PSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDN
           1070         1080        1090      1100      1110       

     1100      1110      1120      1130       
pF1KA1 SFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP    
         :.:                                  
NP_115 MGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
      1120      1130      1140      1150      

>>XP_011541327 (OMIM: 607537) PREDICTED: mastermind-like  (735 aa)
 initn: 1453 init1: 223 opt: 624  Z-score: 288.4  bits: 64.6 E(85289): 2.5e-09
Smith-Waterman score: 841; 31.0% identity (51.3% similar) in 861 aa overlap (41-816:7-710)

               20        30        40        50        60          
pF1KA1 ANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPG--GGSAAVP
                                     : ::      ::: ::..: :  ::....:
XP_011                         MGDTAPPQAP------AGGLGGASGAGLLGGGSVTP
                                       10              20        30

        70        80        90       100       110        120      
pF1KA1 K-HSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLE-QRAKKSG
       . ::..::::: ::  ::.::..::.::.....:. . ::..:..: . . . : :.:.:
XP_011 RVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAG
               40        50        60        70        80        90

        130                                                        
pF1KA1 AGTG---------------------------------------KQQH------------P
         :                                        .:::             
XP_011 KHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGI
              100       110       120       130       140       150

         140       150       160       170       180       190     
pF1KA1 SKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIR--
       .  ::   .. ..::: .:: :: ..:::     :: :. . ::  :..:    ::::  
XP_011 NGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDI-KRIRVG
              160       170       180       190       200          

           200         210       220       230       240       250 
pF1KA1 KDISAGMEA--INNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPE
       ...:::. .  :::  :.. . .. :. :  :. .  :  : ::.::  . : . : : :
XP_011 ENLSAGQGGLQINNGQSQI-MSGTLPMSQAPLRKTNTLP-SHTHSPG--NGLFNMG-LKE
     210       220        230       240        250         260     

                260       270       280         290       300      
pF1KA1 IKLPVN---GCSDLEDSFTILQSKDLKQEPLDDP--TCIDTSETSLSNQNKLFSDINLND
       .:   .   .::   :.  . : . . ..  :::    .:     : :.   .:   ..:
XP_011 VKKEPGETLSCSKHMDG-QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSD
          270       280        290       300       310       320   

        310       320       330       340        350       360     
pF1KA1 QEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETP-LSQESASVKSDPSHSP
        : ...:.    :. .::    :: :. ..     :: .:  : : .:.  .::.  .::
XP_011 LELENMINA---TIKQDDP---FNIDLGQQ-----SQRSTPRPSLPMEKIVIKSE--YSP
           330             340            350       360         370

          370       380       390       400       410       420    
pF1KA1 -FAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQA
        ...   :::: :: :.:: :: ...: :             .:::       :..:.. 
XP_011 GLTQGPSGSPQLRPPSAGPAFSMANSALS-------------TSSPI------PSVPQS-
              380       390                    400             410 

          430       440       450        460       470       480   
pF1KA1 HTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPS-SDMSPAEQLKQMAAQQQQRAKLMQ
           :: :. :.:             ::   :.:: ...: :.::::.::..::.:..  
XP_011 ----QAQPQTGSG-------------ASR--ALPSWQEVSHAQQLKQIAANRQQHARM--
                               420         430       440           

           490       500       510       520       530       540   
pF1KA1 QKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAF
                        ::.::::  : .::: :   ..:  . :  ::  :: .  :.:
XP_011 -----------------QQHQQQH--QPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTF
                      450         460       470       480       490

           550        560              570        580       590    
pF1KA1 NNQNPIVPPMANNL-QKTTMNNYL----PQ---NHMNMINQQ-PNNLGTNSLNKQHNILT
       . :.  .: .:..  :. .: ::.    :.   .:.... :: :..:. . .:. :  . 
XP_011 SPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAME
              500       510       520       530       540       550

            600       610        620       630       640       650 
pF1KA1 --YGNTKPLTHFNADLSQRMTPPV-ANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQ
          :::::: :::.: .... : :  . ::  :. : ::::::::::::::::::    :
XP_011 PRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQ
              560       570       580       590       600       610

             660       670       680       690       700       710 
pF1KA1 LQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGS
        :                .:.                :.:                    
XP_011 QQ----------------QQQ----------------QQQ--------------------
                                                                   

             720       730       740       750       760       770 
pF1KA1 GGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILAE
                        : :..:  :.  .:....  ::.::  ..:.::::::::   .
XP_011 -----------------QQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQ
                       620       630       640       650       660 

             780          790          800       810       820     
pF1KA1 QQLQQSHLPRQHLQPQ---RNPYPVQQ---VNQFQGSPQDIAAVRSQAALQSMRTSRLMA
       :: : :  : : :  :   :.: :.::   ..:.:..:  ::..  :.. :         
XP_011 QQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQP--IAGMGYQVSQQQRQQPVGVS
             670       680       690         700       710         

         830       840       850       860       870       880     
pF1KA1 QNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGM
                                                                   
XP_011 MPDADNIESKCSCKGE                                            
     720       730                                                 

>>XP_016883233 (OMIM: 605299) PREDICTED: nuclear recepto  (2051 aa)
 initn: 499 init1: 201 opt: 492  Z-score: 226.0  bits: 54.6 E(85289): 7.5e-06
Smith-Waterman score: 506; 25.2% identity (49.6% similar) in 939 aa overlap (261-1109:8-868)

              240       250       260       270       280          
pF1KA1 NSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCI---DT
                                     .::: .: : :. ...  .:  . .   ::
XP_016                        MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDT
                                      10        20        30       

       290       300         310       320       330               
pF1KA1 SETSLSNQNKLFSDI--NLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKK-EP-----
       .  :. ... .:  .  :..:....  .: . ..::  ..  . .  .. .: ::     
XP_016 KSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVP--NLLHMESSKLKVQKVEPWNSVR
        40        50        60        70          80        90     

      340           350       360            370       380         
pF1KA1 -EFSQP--ATET--PLSQESASVKSDPSHSPF-----AHVSMGSPQARPSS---SGP--P
         :. :  :.:    :.: . .   : .         . ....  : : ..   .::   
XP_016 VTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGA
         100       110       120       130       140       150     

          390       400            410       420             430   
pF1KA1 FSTVSTATSLPSVASTPAA---PNPASS--PANCAVQSPQT---PN---QAHTPGQAPPR
        ..:   ...: .:: :.     :::.   : .  :.: .    ::   : .::  :   
XP_016 GNSVRMEAGFP-MASGPGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQS
         160        170       180       190       200       210    

           440       450       460       470       480       490   
pF1KA1 PGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQ
        .   ::.   .   .  :: .: :   :.:.   .::   .  . . .::.::::::::
XP_016 DAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQ
          220       230       240       250       260       270    

           500             510          520       530       540    
pF1KA1 QQQQQQQQQQQ------QQHSNQT-SNWSP--LGPPSSPYGAAFTAEKPNSPMMYPQA--
       :::::::::::      :::..:  ..  :   .: . :   ... . :.. .. : :  
XP_016 QQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWN-QLPSGALQPPPAQG
          280       290       300       310        320       330   

                     550        560       570       580       590  
pF1KA1 -----FNNQN----PIVPPMANNLQ-KTTMNNYLPQNHMNMINQQPNNLGTNSLNKQH-N
              ::.    :.  :: ..:: . .. .    .:       :  .:... .. : :
XP_016 SLGTMTANQGWKKAPLPGPMQQQLQARPSLATVQTPSH----PPPPYPFGSQQASQAHTN
           340       350       360       370           380         

                 600       610          620        630         640 
pF1KA1 ILTYGN----TKPLTHFNADLSQRMTPPVANP---NKNPLM-PYIQQQQQQQQQQ--QQQ
       .  ..:    : :  .      .:.  :. .:   ::.:   :   :: .  ..   .: 
XP_016 FPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQT
     390       400       410       420       430       440         

             650              660       670       680       690    
pF1KA1 QQQQQPPPPQ-------LQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPV
       :::. : :::       .: : .  ...      : :.:  : :  . ..    :.: : 
XP_016 QQQMGPRPPQNNPLPQGFQQPVSSPGRNP-----MVQQG--NVPPNFMVM----QQQPP-
     450       460       470            480         490            

          700       710       720       730       740       750    
pF1KA1 GLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQF
           . ::  .:. :: ::.      :.:.:. .:  ..       .   ::  .:. : 
XP_016 ----NQGP--QSLHPGLGGQ------ANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQH
           500         510             520       530       540     

          760       770       780       790       800          810 
pF1KA1 LREQRQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGS---PQDIAAVRS
          :     :.:       .: :: : . .::.      .. ::  :.   :: .     
XP_016 AGGQGAGPPQNQ-------MQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQ-VNLSNM
         550              560       570       580       590        

             820       830       840       850       860       870 
pF1KA1 QAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMST
       :.  :.   :.::...  ..   :::  : :.    :..  : : .    :.  .  :  
XP_016 QGQPQQGPPSQLMGMHQQIV---PSQ--GQMV----QQQGTLNPQNPMILSRAQL--MPQ
       600       610          620             630       640        

             880       890       900       910       920       930 
pF1KA1 GMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPV
       :  ::. .: ..... . ..   :.:  : ::  :..               : :: :: 
XP_016 G--QMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMA--------------PHNQMMGPQ
          650       660       670       680                     690

             940       950       960           970       980       
pF1KA1 GQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQG----MPGRTSGELGPFNNGASYPLQ-
       ::.:   :  : ....: . .:: .  :: . :.    ::: ..   ::  :  .  .: 
XP_016 GQVLL--QQNPMIEQIMTNQMQGNK--QQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQF
                700       710         720       730       740      

        990      1000      1010      1020        1030      1040    
pF1KA1 AGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPS--LPGQQGTSQARPMVMS
       .::  .. : .::   :. :. . . :  ..  .. :   ::  .  :.:   .      
XP_016 TGQ--MSGQMLPQ---QGPVNNSPSQVMGIQGQVL-RPPGPSPHMAQQHGDPATTANNDV
          750          760       770        780       790       800

         1050        1060      1070        1080      1090      1100
pF1KA1 GLSQGVP--GMPAFSQHPAQQQIPSGSFAPSSQ--SQAYERNAPQDVSYNYSGDGAGGSF
       .::: .:  ..   .. : . :  .:. : ...  ....  ::: . . : ... . :. 
XP_016 SLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPN-GNQMSCGQN
              810       820       830       840       850          

             1110      1120      1130                              
pF1KA1 PGLPDGADLVDSIIKGGPGDEWMQELDELFGNP                           
       ::.: . :.                                                   
XP_016 PGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLN
     860       870       880       890       900       910         

>>XP_011541326 (OMIM: 607537) PREDICTED: mastermind-like  (928 aa)
 initn: 1433 init1: 223 opt: 479  Z-score: 225.4  bits: 53.3 E(85289): 8.2e-06
Smith-Waterman score: 841; 27.4% identity (53.0% similar) in 1011 aa overlap (206-1103:1-894)

         180       190       200       210       220       230     
pF1KA1 QQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTH
                                     . ...:. : .::.. .   .::   : ::
XP_011                               MSGTLPM-SQAPLRKTN---TLP---SHTH
                                              10              20   

         240       250          260       270       280         290
pF1KA1 TPGLLEDLSKNGRLPEIKLPVN---GCSDLEDSFTILQSKDLKQEPLDDP--TCIDTSET
       .::  . : . : : :.:   .   .::   :.  . : . . ..  :::    .:    
XP_011 SPG--NGLFNMG-LKEVKKEPGETLSCSKHMDG-QMTQENIFPNRYGDDPGEQLMDPELQ
              30         40        50         60        70         

              300       310       320       330       340          
pF1KA1 SLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETP-
        : :.   .:   ..: : ...:.    :. .::    :: :. ..     :: .:  : 
XP_011 ELFNELTNISVPPMSDLELENMIN---ATIKQDDP---FNIDLGQQ-----SQRSTPRPS
      80        90       100          110               120        

     350       360        370       380       390       400        
pF1KA1 LSQESASVKSDPSHSP-FAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPAS
       : .:.  .::.  .:: ...   :::: :: :.:: :: ...: :             .:
XP_011 LPMEKIVIKSE--YSPGLTQGPSGSPQLRPPSAGPAFSMANSALS-------------TS
      130         140       150       160       170                

      410       420       430       440       450        460       
pF1KA1 SPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPS-SDMSPAEQ
       ::       :..:..     :: :. :.:             ::   :.:: ...: :.:
XP_011 SPI------PSVPQS-----QAQPQTGSG-------------ASR--ALPSWQEVSHAQQ
                 180            190                      200       

       470       480       490       500       510       520       
pF1KA1 LKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAA
       :::.::..::.:..                   ::.::::  : .::: :   ..:  . 
XP_011 LKQIAANRQQHARM-------------------QQHQQQH--QPTNWSALPSSAGPSPGP
       210       220                            230       240      

       530       540       550        560              570         
pF1KA1 FTAEKPNSPMMYPQAFNNQNPIVPPMANNL-QKTTMNNYL----PQ---NHMNMINQQ-P
       :  ::  :: .  :.:. :.  .: .:..  :. .: ::.    :.   .:.... :: :
XP_011 FGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKP
        250       260       270       280       290       300      

      580       590         600       610        620       630     
pF1KA1 NNLGTNSLNKQHNILT--YGNTKPLTHFNADLSQRMTPPV-ANPNKNPLMPYIQQQQQQQ
       ..:. . .:. :  .    :::::: :::.: .... : :  . ::  :. : :::::::
XP_011 QDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQ
        310       320       330       340       350       360      

         640       650                 660           670       680 
pF1KA1 QQQQQQQQQQQPPPPQLQAPR----------AHLSEDQKRLL----LMKQKGVMNQPMAY
       :::::::::::    : :  .          :. ...:.  .     ..:.  ..: .  
XP_011 QQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQ
        370       380       390       400       410       420      

             690       700                        710              
pF1KA1 AALPSHGQEQHPVGLPRTTGPMQ----SSVP-------------PGSG------------
           .. :.:.: . :  . : :    : .:             : .:            
XP_011 QQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQD
        430       440       450       460       470       480      

                 720                730       740       750        
pF1KA1 -----GMVSGASPA---------GPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQ
            :. .: ::.         : :...::   ....:.:. ..  :   :.:  . ::
XP_011 QHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQ--QSLLNQQLMGKKQTL---QRQ--IMEQ
        490       500       510         520       530              

      760       770         780              790       800         
pF1KA1 RQQQQQQQQILA--EQQLQQSHLPRQHLQP-------QRNPYPVQQVNQFQGSPQDIAAV
       .::   :::.::  :.   :... :.  .:       .::   .: . :..:. . :.  
XP_011 KQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLN
     540       550       560       570       580       590         

     810       820       830       840       850       860         
pF1KA1 RSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNM
        .::  . . :  ... :..... . .    ...::.  ..::.  :.. : .::. :..
XP_011 SNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAV--QNMGM--YGNLPCNQPNTYSV
     600       610       620       630         640         650     

     870       880       890       900        910       920        
pF1KA1 STGMTQMLQHPNQSGMSITHNQAQGPRQPASG-QGVGMVSGFGQSMLVNSAITQQHPQMK
       ..::.:. :. : . .  ..:. . :: :. : .. . :. :: . . ::   : .:.. 
XP_011 TSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNS--QQLRPNLT
         660       670       680       690       700         710   

      930       940       950       960          970       980     
pF1KA1 GPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQR---SLQGMPGRTSGELGPFNNGASY-P
         .. ..:    : : ...: : .  : .: ..   : :     ..:   : .. :.: :
XP_011 HSMA-SMP----PQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTP
            720           730       740       750       760        

          990                         1000      1010        1020   
pF1KA1 LQAGQPRLTKQHFPQ-------------------GLSQSVVDANTGTVRTLN--PAAMGR
        :. :  . .:.: :                    .::..   . : .: ::  :  .. 
XP_011 NQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLST
      770       780       790       800       810       820        

          1030      1040      1050      1060      1070      1080   
pF1KA1 QMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQHPAQQQIPSGSFAPSSQSQAYE-RN
       :..:.: .:.::         ::.:.  :.   .: :.    ::.  .:...:.:..  .
XP_011 QILPNL-NQSGT---------GLNQSRTGI---NQPPSLT--PSNFPSPNQSSRAFQGTD
      830                 840          850         860       870   

           1090      1100      1110      1120      1130       
pF1KA1 APQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP    
         .:..... ..   .  :.:                                  
XP_011 HSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
           880       890       900       910       920        

>>XP_011527029 (OMIM: 605299) PREDICTED: nuclear recepto  (2056 aa)
 initn: 499 init1: 201 opt: 490  Z-score: 225.2  bits: 54.4 E(85289): 8.4e-06
Smith-Waterman score: 498; 25.8% identity (49.7% similar) in 764 aa overlap (378-1109:166-873)

       350       360       370       380       390        400      
pF1KA1 TPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTAT-SLPSVASTPAAPNP
                                     : .::: .  ..    . :...  : . : 
XP_011 NLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIFFLGIIRMNNPATVMIPPGGNV
         140       150       160       170       180       190     

        410       420       430       440       450       460      
pF1KA1 ASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAE
       .::     . .:.   : .::  :    .   ::.   .   .  :: .: :   :.:. 
XP_011 SSS---MMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVS
            200       210       220       230       240       250  

        470       480       490       500       510       520      
pF1KA1 QLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGA
         .::  .  .  .:.::.::::::::::::::::::::: . .  .      :..    
XP_011 VNRQM--NPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQG-IRP
              260       270       280       290       300          

        530         540       550       560            570         
pF1KA1 AFTA--EKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNY-----LPQNHMNMINQQPN
        :::  . :  :       .  .:  ::  ..:   : :.      ::   ..... .:.
XP_011 QFTAPTQVPVPPGWNQLPSGALQP--PPAQGSLGTMTANQGWKKAPLPGPMQQQLQARPS
     310       320       330         340       350       360       

     580       590       600       610       620         630       
pF1KA1 NLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNK--NPLMPYIQQQQQQQQQ
        :.: . . .:    :    :.   .:. ..   : ..::..   : :  .:   ..   
XP_011 -LATVQ-TPSHPPPPY----PFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPT
        370        380           390       400       410       420 

       640       650       660       670       680       690       
pF1KA1 QQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLP
         :: .  .  : .  .   . :  ..  . . :. .  .:     :: .: .: ::. :
XP_011 PLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLP-QGFQQ-PVSSP
             430       440       450       460        470          

       700         710       720           730       740        750
pF1KA1 RTTGPM--QSSVPPGSGGMVSGASPAGPGFL----GSQPQAAIMKQMLIDQRAQLI-EQQ
          .::  :..:::.   : .     ::  :    :.: .  .:. .. .  :    .. 
XP_011 -GRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGQANPNFMQGQVPSTTATTPGNSG
      480       490       500       510       520       530        

              760       770        780       790       800         
pF1KA1 KQQFLREQRQQQQQQQQILAEQ-QLQQSHLPRQHLQPQRNPYPVQQVNQFQGS---PQDI
         :.  .:  :.   :     : :.: :: : . .::.      .. ::  :.   :: .
XP_011 APQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQ-V
      540       550       560       570       580       590        

        810       820       830       840       850       860      
pF1KA1 AAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGM
            :.  :.   :.::...  ..   :::  : :.    :..  : : .    :.  .
XP_011 NLSNMQGQPQQGPPSQLMGMHQQIV---PSQ--GQMV----QQQGTLNPQNPMILSRAQL
       600       610       620                630       640        

        870       880       890       900       910       920      
pF1KA1 YNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQ
         :  :  ::. .: ..... . ..   :.:  : ::  :..               : :
XP_011 --MPQG--QMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMA--------------PHNQ
        650         660       670       680                     690

        930       940       950       960           970       980  
pF1KA1 MKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQG----MPGRTSGELGPFNNGAS
       : :: ::.:   :  : ....: . .:: .  :: . :.    ::: ..   ::  :  .
XP_011 MMGPQGQVL--LQQNPMIEQIMTNQMQGNK--QQFNTQNQSNVMPGPAQIMRGPTPNMQG
                700       710         720       730       740      

             990      1000      1010      1020        1030         
pF1KA1 YPLQ-AGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPS--LPGQQGTSQAR
         .: .::  .. : .::   :. :. . . :  ..  .. :   ::  .  :.:   . 
XP_011 NMVQFTGQ--MSGQMLPQ---QGPVNNSPSQVMGIQGQVL-RPPGPSPHMAQQHGDPATT
        750         760          770       780        790       800

    1040      1050        1060      1070        1080      1090     
pF1KA1 PMVMSGLSQGVP--GMPAFSQHPAQQQIPSGSFAPSSQ--SQAYERNAPQDVSYNYSGDG
            .::: .:  ..   .. : . :  .:. : ...  ....  ::: . . : ... 
XP_011 ANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPN-GNQM
              810       820       830       840       850          

        1100      1110      1120      1130                         
pF1KA1 AGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP                      
       . :. ::.: . :.                                              
XP_011 SCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNS
     860       870       880       890       900       910         

>>XP_011541325 (OMIM: 607537) PREDICTED: mastermind-like  (1009 aa)
 initn: 1433 init1: 223 opt: 479  Z-score: 224.9  bits: 53.3 E(85289): 8.7e-06
Smith-Waterman score: 912; 27.9% identity (53.6% similar) in 1061 aa overlap (157-1103:25-975)

        130       140       150       160       170       180      
pF1KA1 AGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFS
                                     :: ..:::     :: :. . ::  :..: 
XP_011       MLCESEHQAMIFLCSPKSLQFPQNLQGSLKRKQVVNLSPANSKRPNGFVDNSFL
                     10        20        30        40        50    

        190         200         210       220       230       240  
pF1KA1 PTSKRIR--KDISAGMEA--INNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLED
          ::::  ...:::. .  :::  :.. . .. :. :  :. .  :  : ::.::  . 
XP_011 DI-KRIRVGENLSAGQGGLQINNGQSQI-MSGTLPMSQAPLRKTNTLP-SHTHSPG--NG
            60        70        80         90       100            

            250          260       270       280         290       
pF1KA1 LSKNGRLPEIKLPVN---GCSDLEDSFTILQSKDLKQEPLDDP--TCIDTSETSLSNQNK
       : . : : :.:   .   .::   :.  . : . . ..  :::    .:     : :.  
XP_011 LFNMG-LKEVKKEPGETLSCSKHMDG-QMTQENIFPNRYGDDPGEQLMDPELQELFNELT
     110        120       130        140       150       160       

       300       310       320       330       340        350      
pF1KA1 LFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETP-LSQESAS
        .:   ..: : ...:.    :. .::    :: :. ..     :: .:  : : .:.  
XP_011 NISVPPMSDLELENMINA---TIKQDDP---FNIDLGQQ-----SQRSTPRPSLPMEKIV
       170       180          190          200            210      

        360        370       380       390       400       410     
pF1KA1 VKSDPSHSP-FAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAV
       .::.  .:: ...   :::: :: :.:: :: ...: :             .:::     
XP_011 IKSE--YSPGLTQGPSGSPQLRPPSAGPAFSMANSALS-------------TSSPI----
        220         230       240       250                        

         420       430       440       450        460       470    
pF1KA1 QSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPS-SDMSPAEQLKQMAAQ
         :..:..     :: :. :.:             ::   :.:: ...: :.::::.::.
XP_011 --PSVPQS-----QAQPQTGSG-------------AS--RALPSWQEVSHAQQLKQIAAN
         260            270                      280       290     

          480       490       500       510       520       530    
pF1KA1 QQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPN
       .::.:..                   ::.::::  : .::: :   ..:  . :  ::  
XP_011 RQQHARM-------------------QQHQQQH--QPTNWSALPSSAGPSPGPFGQEKIP
         300                            310       320       330    

          540       550        560              570        580     
pF1KA1 SPMMYPQAFNNQNPIVPPMANNL-QKTTMNNYL----PQ---NHMNMINQQ-PNNLGTNS
       :: .  :.:. :.  .: .:..  :. .: ::.    :.   .:.... :: :..:. . 
XP_011 SPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSF
          340       350       360       370       380       390    

         590         600       610        620       630       640  
pF1KA1 LNKQHNILT--YGNTKPLTHFNADLSQRMTPPV-ANPNKNPLMPYIQQQQQQQQQQQQQQ
       .:. :  .    :::::: :::.: .... : :  . ::  :. : ::::::::::::::
XP_011 INNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQ
          400       410       420       430       440       450    

            650                 660           670       680        
pF1KA1 QQQQPPPPQLQAPR----------AHLSEDQKRLL----LMKQKGVMNQPMAYAALPSHG
       ::::    : :  .          :. ...:.  .     ..:.  ..: .      .. 
XP_011 QQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQ
          460       470       480       490       500       510    

      690       700                        710                     
pF1KA1 QEQHPVGLPRTTGPMQ----SSVP-------------PGSG-----------------GM
       :.:.: . :  . : :    : .:             : .:                 :.
XP_011 QQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQ
          520       530       540       550       560       570    

          720                730       740          750       760  
pF1KA1 VSGASPA---------GPGFLGSQPQAAIMKQMLIDQRAQL---IEQQKQQFLREQRQQQ
        .: ::.         : :...::   ....:.:. ..  :   : .::::.: .: :. 
XP_011 NTGPSPSPNPCSNPNTGSGYMNSQQ--SLLNQQLMGKKQTLQRQIMEQKQQLLLQQ-QML
          580       590         600       610       620        630 

            770          780       790       800       810         
pF1KA1 QQQQQILAEQQLQQSHL---PRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMR
        . ..:  ..:... ::   : .. . .::   .: . :..:. . :.   .::  . . 
XP_011 ADAEKIAPQDQINR-HLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVS
             640        650       660       670       680       690

     820       830       840       850       860       870         
pF1KA1 TSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQH
       :  ... :..... . .    ...::.  ..::.  :.. : .::. :....::.:. :.
XP_011 THTILTPNSSLLSTSHGTRMPSLSTAV--QNMGM--YGNLPCNQPNTYSVTSGMNQLTQQ
              700       710         720         730       740      

     880       890       900        910       920       930        
pF1KA1 PNQSGMSITHNQAQGPRQPASG-QGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRP
        : . .  ..:. . :: :. : .. . :. :: . . ::   : .:..   .. ..:  
XP_011 RNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQ--QLRPNLTHSMA-SMP--
        750       760       770       780         790        800   

      940       950       960          970       980        990    
pF1KA1 QAPPRLQSLMGTVQQGAQSWQQR---SLQGMPGRTSGELGPFNNGASY-PLQAGQPRLTK
         : : ...: : .  : .: ..   : :     ..:   : .. :.: : :. :  . .
XP_011 --PQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGS
               810       820       830       840       850         

                            1000      1010        1020      1030   
pF1KA1 QHFPQ-------------------GLSQSVVDANTGTVRTLN--PAAMGRQMMPSLPGQQ
       :.: :                    .::..   . : .: ::  :  .. :..:.: .:.
XP_011 QQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNL-NQS
     860       870       880       890       900       910         

          1040      1050      1060      1070      1080       1090  
pF1KA1 GTSQARPMVMSGLSQGVPGMPAFSQHPAQQQIPSGSFAPSSQSQAYE-RNAPQDVSYNYS
       ::         ::.:.  :.   .: :.    ::.  .:...:.:..  .  .:..... 
XP_011 GT---------GLNQSRTGI---NQPPSLT--PSNFPSPNQSSRAFQGTDHSSDLAFDFL
      920                   930         940       950       960    

           1100      1110      1120      1130       
pF1KA1 GDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP    
       ..   .  :.:                                  
XP_011 SQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
          970       980       990      1000         

>>XP_011527028 (OMIM: 605299) PREDICTED: nuclear recepto  (2057 aa)
 initn: 499 init1: 201 opt: 486  Z-score: 223.5  bits: 54.1 E(85289): 1e-05
Smith-Waterman score: 496; 26.0% identity (49.4% similar) in 786 aa overlap (378-1109:166-874)

       350       360       370       380       390        400      
pF1KA1 TPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTAT-SLPSVASTPAAPNP
                                     : .::: .  ..    . :...  : . : 
XP_011 NLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIFFLGIIRMNNPATVMIPPGGNV
         140       150       160       170       180       190     

        410       420       430       440       450       460      
pF1KA1 ASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAE
       .::     . .:.   : .::  :    .   ::.   .   .  :: .: :   :.:. 
XP_011 SSS---MMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVS
            200       210       220       230       240       250  

        470       480       490       500             510          
pF1KA1 QLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQ------QQHSNQT-SNWSP--L
         .::   .  . . .::.:::::::::::::::::::      :::..:  ..  :   
XP_011 VNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFT
            260       270       280       290       300       310  

       520       530       540                  550        560     
pF1KA1 GPPSSPYGAAFTAEKPNSPMMYPQA-------FNNQN----PIVPPMANNLQ-KTTMNNY
       .: . :   ... . :.. .. : :         ::.    :.  :: ..:: . .. . 
XP_011 APTQVPVPPGWN-QLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQARPSLATV
            320        330       340       350       360       370 

         570       580       590            600       610          
pF1KA1 LPQNHMNMINQQPNNLGTNSLNKQH-NILTYGN----TKPLTHFNADLSQRMTPPVANP-
          .:       :  .:... .. : :.  ..:    : :  .      .:.  :. .: 
XP_011 QTPSH----PPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPH
                 380       390       400       410       420       

       620        630         640       650              660       
pF1KA1 --NKNPLM-PYIQQQQQQQQQQ--QQQQQQQQPPPPQ-------LQAPRAHLSEDQKRLL
         ::.:   :   :: .  ..   .: :::. : :::       .: : .  ...     
XP_011 LTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNP----
       430       440       450       460       470       480       

       670       680       690       700       710       720       
pF1KA1 LMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLG
        : :.:  : :  . ..    :.: :     . ::.  :. :: :     :. :.:.:. 
XP_011 -MVQQG--NVPPNFMVM----QQQPP-----NQGPQ--SLHPGLG-----AGQANPNFMQ
              490           500              510            520    

       730       740       750       760       770       780       
pF1KA1 SQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILAEQQLQQSHLPRQHLQPQ
       .:  ..       .   ::  .:. :    :     :.:       .: :: : . .::.
XP_011 GQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQ-------MQVSHGPPNMMQPS
          530       540       550       560              570       

       790       800          810       820       830       840    
pF1KA1 RNPYPVQQVNQFQGS---PQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMAT
             .. ::  :.   :: .     :.  :.   :.::...  ..   :::  : :. 
XP_011 LMGIHGNMNNQQAGTSGVPQ-VNLSNMQGQPQQGPPSQLMGMHQQIV---PSQ--GQMV-
       580       590        600       610       620            630 

          850       860       870       880       890       900    
pF1KA1 AAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGV
          :..  : : .    :.  .  :  :  ::. .: ..... . ..   :.:  : :: 
XP_011 ---QQQGTLNPQNPMILSRAQL--MPQG--QMMVNPPSQNLGPSPQRMTPPKQMLSQQGP
                 640         650         660       670       680   

          910       920       930       940       950       960    
pF1KA1 GMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQ
        :..               : :: :: ::.:   :  : ....: . .:: .  :: . :
XP_011 QMMA--------------PHNQMMGPQGQVL--LQQNPMIEQIMTNQMQGNK--QQFNTQ
                         690       700         710         720     

              970       980        990      1000      1010         
pF1KA1 G----MPGRTSGELGPFNNGASYPLQ-AGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPA
       .    ::: ..   ::  :  .  .: .::  .. : .::   :. :. . . :  ..  
XP_011 NQSNVMPGPAQIMRGPTPNMQGNMVQFTGQ--MSGQMLPQ---QGPVNNSPSQVMGIQGQ
         730       740       750         760          770       780

    1020        1030      1040      1050        1060      1070     
pF1KA1 AMGRQMMPS--LPGQQGTSQARPMVMSGLSQGVP--GMPAFSQHPAQQQIPSGSFAPSSQ
       .. :   ::  .  :.:   .      .::: .:  ..   .. : . :  .:. : ...
XP_011 VL-RPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNH
               790       800       810       820       830         

          1080      1090      1100      1110      1120      1130   
pF1KA1 --SQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP
         ....  ::: . . : ... . :. ::.: . :.                        
XP_011 FSGHGMSFNAPFSGAPN-GNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNN
     840       850        860       870       880       890        

XP_011 KQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLP
      900       910       920       930       940       950        

>>XP_016883239 (OMIM: 605299) PREDICTED: nuclear recepto  (1094 aa)
 initn: 499 init1: 201 opt: 443  Z-score: 209.1  bits: 50.5 E(85289): 6.6e-05
Smith-Waterman score: 482; 25.6% identity (49.2% similar) in 801 aa overlap (378-1109:166-904)

       350       360       370       380       390        400      
pF1KA1 TPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTAT-SLPSVASTPAAPNP
                                     : .::: .  ..    . :...  : . : 
XP_016 NLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIFFLGIIRMNNPATVMIPPGGNV
         140       150       160       170       180       190     

        410       420       430       440       450       460      
pF1KA1 ASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAE
       .::     . .:.   : .::  :    .   ::.   .   .  :: .: :   :.:. 
XP_016 SSS---MMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVS
            200       210       220       230       240       250  

        470       480       490       500             510          
pF1KA1 QLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQ------QQHSNQT-SNWSP--L
         .::   .  . . .::.:::::::::::::::::::      :::..:  ..  :   
XP_016 VNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFT
            260       270       280       290       300       310  

       520       530       540                  550        560     
pF1KA1 GPPSSPYGAAFTAEKPNSPMMYPQA-------FNNQN----PIVPPMANNLQ-KTTMNNY
       .: . :   ... . :.. .. : :         ::.    :.  :: ..:: . .. . 
XP_016 APTQVPVPPGWN-QLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQARPSLATV
            320        330       340       350       360       370 

         570       580       590            600       610          
pF1KA1 LPQNHMNMINQQPNNLGTNSLNKQH-NILTYGN----TKPLTHFNADLSQRMTPPVANP-
          .:       :  .:... .. : :.  ..:    : :  .      .:.  :. .: 
XP_016 QTPSH----PPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPH
                 380       390       400       410       420       

       620        630         640       650              660       
pF1KA1 --NKNPLM-PYIQQQQQQQQQQ--QQQQQQQQPPPPQ-------LQAPRAHLSEDQKRLL
         ::.:   :   :: .  ..   .: :::. : :::       .: : .  ...     
XP_016 LTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNP----
       430       440       450       460       470       480       

       670       680            690       700         710          
pF1KA1 LMKQKGVMNQPMAYAAL----PSHG-QEQHPVGLPRTTGPMQSSV--PPGS--------G
        : :.:  : :  . ..    :..: :  :: :: . . : . .:  :  .        .
XP_016 -MVQQG--NVPPNFMVMQQQPPNQGPQSLHP-GLGEKSEPSNLAVAWPQITFREQIAIFS
              490       500       510        520       530         

            720       730       740       750       760       770  
pF1KA1 GMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILAEQ
          : .. :.:.:. .:  ..       .   ::  .:. :    :     :.:      
XP_016 LACSKSGQANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQ------
     540       550       560       570       580       590         

            780       790       800          810       820         
pF1KA1 QLQQSHLPRQHLQPQRNPYPVQQVNQFQGS---PQDIAAVRSQAALQSMRTSRLMAQNAG
        .: :: : . .::.      .. ::  :.   :: .     :.  :.   :.::...  
XP_016 -MQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQ-VNLSNMQGQPQQGPPSQLMGMHQQ
            600       610       620        630       640       650 

     830       840       850       860       870       880         
pF1KA1 MMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITH
       ..   :::  : :.    :..  : : .    :.  .  :  :  ::. .: ..... . 
XP_016 IV---PSQ--GQMV----QQQGTLNPQNPMILSRAQL--MPQG--QMMVNPPSQNLGPSP
                  660           670         680         690        

     890       900       910       920       930       940         
pF1KA1 NQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMG
       ..   :.:  : ::  :..               : :: :: ::.:   :  : ....: 
XP_016 QRMTPPKQMLSQQGPQMMA--------------PHNQMMGPQGQVL--LQQNPMIEQIMT
      700       710                     720       730         740  

     950       960           970       980        990      1000    
pF1KA1 TVQQGAQSWQQRSLQG----MPGRTSGELGPFNNGASYPLQ-AGQPRLTKQHFPQGLSQS
       . .:: .  :: . :.    ::: ..   ::  :  .  .: .::  .. : .::   :.
XP_016 NQMQGNK--QQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQ--MSGQMLPQ---QG
              750       760       770       780         790        

         1010      1020        1030      1040      1050        1060
pF1KA1 VVDANTGTVRTLNPAAMGRQMMPS--LPGQQGTSQARPMVMSGLSQGVP--GMPAFSQHP
        :. . . :  ..  .. :   ::  .  :.:   .      .::: .:  ..   .. :
XP_016 PVNNSPSQVMGIQGQVL-RPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVP
         800       810        820       830       840       850    

             1070        1080      1090      1100      1110        
pF1KA1 AQQQIPSGSFAPSSQ--SQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGP
        . :  .:. : ...  ....  ::: . . : ... . :. ::.: . :.         
XP_016 PHVQAMQGNSASGNHFSGHGMSFNAPFSGAPN-GNQMSCGQNPGFPVNKDVTLTSPLLVN
          860       870       880        890       900       910   

     1120      1130                                                
pF1KA1 GDEWMQELDELFGNP                                             
                                                                   
XP_016 LLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLP
           920       930       940       950       960       970   




1133 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 01:51:17 2016 done: Fri Nov  4 01:51:19 2016
 Total Scan time: 14.520 Total Display time:  0.320

Function used was FASTA [36.3.4 Apr, 2011]
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