Result of FASTA (omim) for pF1KB9464
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9464, 1190 aa
  1>>>pF1KB9464 1190 - 1190 aa - 1190 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.0293+/-0.000532; mu= -3.8753+/- 0.033
 mean_var=377.4474+/-77.839, 0's: 0 Z-trim(119.6): 231  B-trim: 874 in 1/52
 Lambda= 0.066016
 statistics sampled from 33676 (33925) to 33676 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.398), width:  16
 Scan time: 15.990

The best scores are:                                      opt bits E(85289)
NP_004808 (OMIM: 607709,607748,615878) tight junct (1190) 7952 772.9       0
XP_005252371 (OMIM: 607709,607748,615878) PREDICTE (1194) 7811 759.4 2.9e-218
NP_001163887 (OMIM: 607709,607748,615878) tight ju (1221) 7804 758.8 4.7e-218
XP_016870815 (OMIM: 607709,607748,615878) PREDICTE (1213) 7800 758.4 6.1e-218
XP_011517508 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
XP_011517511 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
XP_011517510 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
XP_011517509 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
NP_963923 (OMIM: 607709,607748,615878) tight junct (1043) 6410 626.0 3.9e-178
XP_016870816 (OMIM: 607709,607748,615878) PREDICTE (1153) 6411 626.1 3.9e-178
XP_016870817 (OMIM: 607709,607748,615878) PREDICTE (1047) 6269 612.5 4.3e-174
NP_001163886 (OMIM: 607709,607748,615878) tight ju (1157) 6270 612.7 4.3e-174
NP_001163885 (OMIM: 607709,607748,615878) tight ju (1020) 6234 609.2 4.3e-173
XP_011517506 (OMIM: 607709,607748,615878) PREDICTE (1130) 6235 609.3 4.3e-173
NP_003248 (OMIM: 601009) tight junction protein ZO (1748) 1908 197.4 6.7e-49
XP_016878018 (OMIM: 601009) PREDICTED: tight junct (1755) 1908 197.4 6.7e-49
XP_016878017 (OMIM: 601009) PREDICTED: tight junct (1759) 1908 197.4 6.7e-49
NP_001317168 (OMIM: 601009) tight junction protein (1768) 1908 197.4 6.8e-49
XP_016878016 (OMIM: 601009) PREDICTED: tight junct (1783) 1908 197.4 6.8e-49
XP_016878015 (OMIM: 601009) PREDICTED: tight junct (1785) 1908 197.4 6.8e-49
XP_016878014 (OMIM: 601009) PREDICTED: tight junct (1789) 1908 197.4 6.8e-49
NP_001287954 (OMIM: 601009) tight junction protein (1835) 1908 197.4   7e-49
XP_005254674 (OMIM: 601009) PREDICTED: tight junct (1841) 1908 197.4   7e-49
XP_011520274 (OMIM: 601009) PREDICTED: tight junct (1848) 1908 197.4   7e-49
XP_016878012 (OMIM: 601009) PREDICTED: tight junct (1858) 1908 197.4   7e-49
XP_016878011 (OMIM: 601009) PREDICTED: tight junct (1865) 1908 197.4   7e-49
XP_016878010 (OMIM: 601009) PREDICTED: tight junct (1878) 1908 197.4 7.1e-49
XP_016878020 (OMIM: 601009) PREDICTED: tight junct (1452) 1902 196.8 8.7e-49
NP_783297 (OMIM: 601009) tight junction protein ZO (1668) 1886 195.3 2.8e-48
XP_016878019 (OMIM: 601009) PREDICTED: tight junct (1688) 1886 195.3 2.8e-48
NP_001287955 (OMIM: 601009) tight junction protein (1692) 1886 195.3 2.8e-48
XP_005254677 (OMIM: 601009) PREDICTED: tight junct (1761) 1886 195.3 2.9e-48
XP_005254676 (OMIM: 601009) PREDICTED: tight junct (1781) 1886 195.3 2.9e-48
XP_016878013 (OMIM: 601009) PREDICTED: tight junct (1798) 1886 195.3 2.9e-48
NP_001254489 (OMIM: 612689) tight junction protein ( 919) 1479 156.3 8.4e-37
NP_001254490 (OMIM: 612689) tight junction protein ( 928) 1479 156.3 8.4e-37


>>NP_004808 (OMIM: 607709,607748,615878) tight junction   (1190 aa)
 initn: 7952 init1: 7952 opt: 7952  Z-score: 4112.0  bits: 772.9 E(85289):    0
Smith-Waterman score: 7952; 99.7% identity (99.9% similar) in 1190 aa overlap (1-1190:1-1190)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_004 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
             1150      1160      1170      1180      1190

>>XP_005252371 (OMIM: 607709,607748,615878) PREDICTED: t  (1194 aa)
 initn: 7806 init1: 7806 opt: 7811  Z-score: 4039.4  bits: 759.4 E(85289): 2.9e-218
Smith-Waterman score: 7811; 99.2% identity (99.6% similar) in 1179 aa overlap (13-1190:16-1194)

                  10         20        30        40        50      
pF1KB9    MPVRGDRGFPPRRELSGWL-RAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPH
                      ..:  :  :::::::::::::::::::::::::::::::::::::
XP_005 MKTAQALHRMWIQAVKKLRRWKGRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPH
               10        20        30        40        50        60

         60        70        80        90       100       110      
pF1KB9 FENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVV
               70        80        90       100       110       120

        120       130       140       150       160       170      
pF1KB9 KRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPE
              130       140       150       160       170       180

        180       190       200       210       220       230      
pF1KB9 RGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRD
              190       200       210       220       230       240

        240       250       260       270       280       290      
pF1KB9 RDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPS
              250       260       270       280       290       300

        300       310       320       330       340       350      
pF1KB9 PEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT
              310       320       330       340       350       360

        360       370       380       390       400       410      
pF1KB9 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSP
              370       380       390       400       410       420

        420       430       440       450       460       470      
pF1KB9 EERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKE
              430       440       450       460       470       480

        480       490       500       510       520       530      
pF1KB9 PRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVA
       :::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVA
              490       500       510       520       530       540

        540       550       560       570       580       590      
pF1KB9 GIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYR
              550       560       570       580       590       600

        600       610       620       630       640       650      
pF1KB9 DILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK
              610       620       630       640       650       660

        660       670       680       690       700       710      
pF1KB9 GLIPNKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKF
       :::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKF
              670       680       690       700       710       720

        720       730       740       750       760       770      
pF1KB9 PAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRL
              730       740       750       760       770       780

        780       790       800       810       820       830      
pF1KB9 NTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSS
              790       800       810       820       830       840

        840       850       860       870       880       890      
pF1KB9 RKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 
XP_005 RKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDD
              850       860       870       880       890       900

        900       910       920       930       940       950      
pF1KB9 PEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPV
              910       920       930       940       950       960

        960       970       980       990      1000      1010      
pF1KB9 QHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYK
              970       980       990      1000      1010      1020

       1020      1030      1040      1050      1060      1070      
pF1KB9 SNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPK
             1030      1040      1050      1060      1070      1080

       1080      1090      1100      1110      1120      1130      
pF1KB9 SVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTS
             1090      1100      1110      1120      1130      1140

       1140      1150      1160      1170      1180      1190
pF1KB9 SRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
             1150      1160      1170      1180      1190    

>>NP_001163887 (OMIM: 607709,607748,615878) tight juncti  (1221 aa)
 initn: 7803 init1: 7803 opt: 7804  Z-score: 4035.7  bits: 758.8 E(85289): 4.7e-218
Smith-Waterman score: 7804; 98.6% identity (98.9% similar) in 1190 aa overlap (9-1190:35-1221)

                                     10                20        30
pF1KB9                       MPVRGDRGFPPRRELSGW--------LRAPGMEELIWE
                                     ::   .::.:        : ::::::::::
NP_001 QALHRMWIQAVKKLRRWKGRVSPSASSPLVFP---NLSSWEGEGSKTILTAPGMEELIWE
           10        20        30           40        50        60 

               40        50        60        70        80        90
pF1KB9 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNG
              70        80        90       100       110       120 

              100       110       120       130       140       150
pF1KB9 TPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRS
             130       140       150       160       170       180 

              160       170       180       190       200       210
pF1KB9 FRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHA
             190       200       210       220       230       240 

              220       230       240       250       260       270
pF1KB9 RTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYR
             250       260       270       280       290       300 

              280       290       300       310       320       330
pF1KB9 RGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVK
             310       320       330       340       350       360 

              340       350       360       370       380       390
pF1KB9 EMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLI
             370       380       390       400       410       420 

              400       410       420       430       440       450
pF1KB9 NIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLS
             430       440       450       460       470       480 

              460       470       480       490       500       510
pF1KB9 RMGATPTPFKSTGDIAGTVVPETNKEPRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNT
       :::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_001 RMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNT
             490       500       510       520       530       540 

              520       530       540       550       560       570
pF1KB9 KMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVRED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVRED
             550       560       570       580       590       600 

              580       590       600       610       620       630
pF1KB9 AVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEV
             610       620       630       640       650       660 

              640       650       660       670       680       690
pF1KB9 FRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQIASVQNAQRDNAGDRADFWRMRG
       :::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_001 FRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRG
             670       680       690       700       710       720 

              700       710       720       730       740       750
pF1KB9 QRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANE
             730       740       750       760       770       780 

              760       770       780       790       800       810
pF1KB9 LPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIV
             790       800       810       820       830       840 

              820       830       840       850       860       870
pF1KB9 IFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGS
             850       860       870       880       890       900 

              880       890       900       910       920       930
pF1KB9 LKDTIQHQQGEAVWVSEGKMEGMDDHPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGG
       ::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 LKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGG
             910       920       930       940       950       960 

              940       950       960       970       980       990
pF1KB9 AYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPA
             970       980       990      1000      1010      1020 

             1000      1010      1020      1030      1040      1050
pF1KB9 FKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSIL
            1030      1040      1050      1060      1070      1080 

             1060      1070      1080      1090      1100      1110
pF1KB9 KPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEI
            1090      1100      1110      1120      1130      1140 

             1120      1130      1140      1150      1160      1170
pF1KB9 AQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQL
            1150      1160      1170      1180      1190      1200 

             1180      1190
pF1KB9 SEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::
NP_001 SEHSKRGYYGQSARYRDTEL
            1210      1220 

>>XP_016870815 (OMIM: 607709,607748,615878) PREDICTED: t  (1213 aa)
 initn: 7800 init1: 7800 opt: 7800  Z-score: 4033.7  bits: 758.4 E(85289): 6.1e-218
Smith-Waterman score: 7800; 99.7% identity (99.9% similar) in 1171 aa overlap (20-1190:43-1213)

                          10        20        30        40         
pF1KB9            MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVS
                                     .:::::::::::::::::::::::::::::
XP_016 PCEWDWHPGCSSRSKYSRKHRAVPVHGPRCQAPGMEELIWEQYTVTLQKDSKRGFGIAVS
             20        30        40        50        60        70  

      50        60        70        80        90       100         
pF1KB9 GGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSG
             80        90       100       110       120       130  

     110       120       130       140       150       160         
pF1KB9 KVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSR
            140       150       160       170       180       190  

     170       180       190       200       210       220         
pF1KB9 SWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDF
            200       210       220       230       240       250  

     230       240       250       260       270       280         
pF1KB9 GPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREH
            260       270       280       290       300       310  

     290       300       310       320       330       340         
pF1KB9 PHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDI
            320       330       340       350       360       370  

     350       360       370       380       390       400         
pF1KB9 ILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIE
            380       390       400       410       420       430  

     410       420       430       440       450       460         
pF1KB9 SNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTV
            440       450       460       470       480       490  

     470       480       490       500       510       520         
pF1KB9 VPETNKEPRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGN
       ::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGN
            500       510       520       530       540       550  

     530       540       550       560       570       580         
pF1KB9 DVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ
            560       570       580       590       600       610  

     590       600       610       620       630       640         
pF1KB9 SRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVR
            620       630       640       650       660       670  

     650       660       670       680       690       700         
pF1KB9 IGNELEKGLIPNKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV
       ::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 IGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV
            680       690       700       710       720       730  

     710       720       730       740       750       760         
pF1KB9 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEK
            740       750       760       770       780       790  

     770       780       790       800       810       820         
pF1KB9 STGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLN
            800       810       820       830       840       850  

     830       840       850       860       870       880         
pF1KB9 PTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGK
            860       870       880       890       900       910  

     890       900       910       920       930       940         
pF1KB9 MEGMDDHPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSI
       :::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSI
            920       930       940       950       960       970  

     950       960       970       980       990      1000         
pF1KB9 TRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDF
            980       990      1000      1010      1020      1030  

    1010      1020      1030      1040      1050      1060         
pF1KB9 SKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSE
           1040      1050      1060      1070      1080      1090  

    1070      1080      1090      1100      1110      1120         
pF1KB9 EQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDP
           1100      1110      1120      1130      1140      1150  

    1130      1140      1150      1160      1170      1180         
pF1KB9 GTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTE
           1160      1170      1180      1190      1200      1210  

    1190
pF1KB9 L
       :
XP_016 L
        

>>XP_011517508 (OMIM: 607709,607748,615878) PREDICTED: t  (1167 aa)
 initn: 7776 init1: 7776 opt: 7776  Z-score: 4021.6  bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                              :::::::::::::::::::::::::::::::::::::
XP_011                        MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                                      10        20        30       

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
        40        50        60        70        80        90       

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       160       170       180       190       200       210       

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       220       230       240       250       260       270       

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       280       290       300       310       320       330       

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       340       350       360       370       380       390       

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       400       410       420       430       440       450       

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       460       470       480       490       500       510       

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       520       530       540       550       560       570       

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       580       590       600       610       620       630       

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       640       650       660       670       680       690       

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       700       710       720       730       740       750       

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       760       770       780       790       800       810       

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
       820       830       840       850       860       870       

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       880       890       900       910       920       930       

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       940       950       960       970       980       990       

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
      1000      1010      1020      1030      1040      1050       

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
      1060      1070      1080      1090      1100      1110       

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
      1120      1130      1140      1150      1160       

>>XP_011517511 (OMIM: 607709,607748,615878) PREDICTED: t  (1167 aa)
 initn: 7776 init1: 7776 opt: 7776  Z-score: 4021.6  bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                              :::::::::::::::::::::::::::::::::::::
XP_011                        MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                                      10        20        30       

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
        40        50        60        70        80        90       

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       160       170       180       190       200       210       

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       220       230       240       250       260       270       

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       280       290       300       310       320       330       

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       340       350       360       370       380       390       

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       400       410       420       430       440       450       

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       460       470       480       490       500       510       

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       520       530       540       550       560       570       

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       580       590       600       610       620       630       

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       640       650       660       670       680       690       

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       700       710       720       730       740       750       

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       760       770       780       790       800       810       

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
       820       830       840       850       860       870       

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       880       890       900       910       920       930       

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       940       950       960       970       980       990       

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
      1000      1010      1020      1030      1040      1050       

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
      1060      1070      1080      1090      1100      1110       

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
      1120      1130      1140      1150      1160       

>>XP_011517510 (OMIM: 607709,607748,615878) PREDICTED: t  (1167 aa)
 initn: 7776 init1: 7776 opt: 7776  Z-score: 4021.6  bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                              :::::::::::::::::::::::::::::::::::::
XP_011                        MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                                      10        20        30       

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
        40        50        60        70        80        90       

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       160       170       180       190       200       210       

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       220       230       240       250       260       270       

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       280       290       300       310       320       330       

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       340       350       360       370       380       390       

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       400       410       420       430       440       450       

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       460       470       480       490       500       510       

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       520       530       540       550       560       570       

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       580       590       600       610       620       630       

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       640       650       660       670       680       690       

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       700       710       720       730       740       750       

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       760       770       780       790       800       810       

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
       820       830       840       850       860       870       

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       880       890       900       910       920       930       

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       940       950       960       970       980       990       

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
      1000      1010      1020      1030      1040      1050       

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
      1060      1070      1080      1090      1100      1110       

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
      1120      1130      1140      1150      1160       

>>XP_011517509 (OMIM: 607709,607748,615878) PREDICTED: t  (1167 aa)
 initn: 7776 init1: 7776 opt: 7776  Z-score: 4021.6  bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                              :::::::::::::::::::::::::::::::::::::
XP_011                        MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
                                      10        20        30       

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
        40        50        60        70        80        90       

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       100       110       120       130       140       150       

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       160       170       180       190       200       210       

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       220       230       240       250       260       270       

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       280       290       300       310       320       330       

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       340       350       360       370       380       390       

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       400       410       420       430       440       450       

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       460       470       480       490       500       510       

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       520       530       540       550       560       570       

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       580       590       600       610       620       630       

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       640       650       660       670       680       690       

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       700       710       720       730       740       750       

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       760       770       780       790       800       810       

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
       820       830       840       850       860       870       

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       880       890       900       910       920       930       

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
       940       950       960       970       980       990       

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
      1000      1010      1020      1030      1040      1050       

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
      1060      1070      1080      1090      1100      1110       

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
      1120      1130      1140      1150      1160       

>>NP_963923 (OMIM: 607709,607748,615878) tight junction   (1043 aa)
 initn: 6391 init1: 6391 opt: 6410  Z-score: 3319.1  bits: 626.0 E(85289): 3.9e-178
Smith-Waterman score: 6664; 87.4% identity (87.6% similar) in 1190 aa overlap (1-1190:1-1043)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_963 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
                                                                   
NP_963 ------------------------------------------------------------
                                                                   

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
                                                                   
NP_963 ------------------------------------------------------------
                                                                   

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
                                  :::::::::::::::::::::::::::::::::
NP_963 ---------------------------IEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
                                         970       980       990   

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
          1000      1010      1020      1030      1040   

>>XP_016870816 (OMIM: 607709,607748,615878) PREDICTED: t  (1153 aa)
 initn: 6598 init1: 6392 opt: 6411  Z-score: 3319.0  bits: 626.1 E(85289): 3.9e-178
Smith-Waterman score: 7606; 96.6% identity (96.8% similar) in 1190 aa overlap (1-1190:1-1153)

               10        20        30        40        50        60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
       :.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
       :::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_016 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
                                            :::::::::::::::::::::::
XP_016 -------------------------------------AKTQNKEESYDFSKSYEYKSNPS
                                                   970       980   

             1030      1040      1050      1060      1070      1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
           990      1000      1010      1020      1030      1040   

             1090      1100      1110      1120      1130      1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
          1050      1060      1070      1080      1090      1100   

             1150      1160      1170      1180      1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
          1110      1120      1130      1140      1150   




1190 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:36:31 2016 done: Thu Nov  3 23:36:33 2016
 Total Scan time: 15.990 Total Display time:  0.450

Function used was FASTA [36.3.4 Apr, 2011]
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