Result of FASTA (omim) for pF1KSDA1819
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1819, 1153 aa
  1>>>pF1KSDA1819 1153 - 1153 aa - 1153 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.6512+/-0.000463; mu= -14.3055+/- 0.029
 mean_var=580.2177+/-123.297, 0's: 0 Z-trim(123.2): 262  B-trim: 1788 in 1/57
 Lambda= 0.053245
 statistics sampled from 42278 (42586) to 42278 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.499), width:  16
 Scan time: 17.370

The best scores are:                                      opt bits E(85289)
NP_115803 (OMIM: 607537) mastermind-like protein 2 (1156) 7778 613.4 2.6e-174
XP_011541325 (OMIM: 607537) PREDICTED: mastermind- (1009) 6613 523.8 2.1e-147
XP_011541326 (OMIM: 607537) PREDICTED: mastermind- ( 928) 6246 495.6 5.9e-139
XP_011541327 (OMIM: 607537) PREDICTED: mastermind- ( 735) 4813 385.4 6.8e-106
NP_061187 (OMIM: 608991) mastermind-like protein 3 (1133)  656 66.3 1.3e-09
NP_005111 (OMIM: 300188,300895,305450,309520) medi (2177)  566 59.6 2.4e-07
NP_055572 (OMIM: 605424) mastermind-like protein 1 (1016)  520 55.8 1.6e-06
NP_001280163 (OMIM: 607372) mediator of RNA polyme ( 731)  506 54.6 2.7e-06
XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525)  516 56.1 6.9e-06
XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536)  516 56.1 6.9e-06
NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537)  516 56.1 6.9e-06
XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537)  516 56.1 6.9e-06
XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540)  516 56.1 6.9e-06
XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549)  516 56.1 6.9e-06
XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552)  516 56.1 6.9e-06
XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553)  516 56.1 6.9e-06
XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555)  516 56.1 6.9e-06
XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556)  516 56.1 6.9e-06
XP_016884309 (OMIM: 607372) PREDICTED: mediator of ( 667)  465 51.4 2.2e-05
NP_001280166 (OMIM: 607372) mediator of RNA polyme ( 722)  465 51.4 2.4e-05
NP_001280164 (OMIM: 607372) mediator of RNA polyme ( 722)  465 51.4 2.4e-05
NP_056973 (OMIM: 607372) mediator of RNA polymeras ( 748)  465 51.4 2.4e-05
XP_006724327 (OMIM: 607372) PREDICTED: mediator of ( 707)  453 50.5 4.4e-05
XP_016884308 (OMIM: 607372) PREDICTED: mediator of ( 707)  453 50.5 4.4e-05
XP_016884307 (OMIM: 607372) PREDICTED: mediator of ( 707)  453 50.5 4.4e-05
XP_011528517 (OMIM: 607372) PREDICTED: mediator of ( 741)  453 50.5 4.6e-05
XP_016884306 (OMIM: 607372) PREDICTED: mediator of ( 749)  453 50.5 4.6e-05
XP_011528516 (OMIM: 607372) PREDICTED: mediator of ( 762)  453 50.5 4.6e-05
NP_001003891 (OMIM: 607372) mediator of RNA polyme ( 788)  453 50.5 4.8e-05
NP_001280165 (OMIM: 607372) mediator of RNA polyme ( 677)  450 50.2   5e-05
NP_683698 (OMIM: 602081,605317) forkhead box prote ( 732)  439 49.4 9.5e-05
XP_006724326 (OMIM: 607372) PREDICTED: mediator of ( 717)  438 49.3 9.9e-05
XP_016884310 (OMIM: 607372) PREDICTED: mediator of ( 520)  421 47.9 0.00019
NP_683697 (OMIM: 602081,605317) forkhead box prote ( 432)  415 47.4 0.00023
NP_001166238 (OMIM: 602081,605317) forkhead box pr ( 457)  415 47.4 0.00024
XP_016883240 (OMIM: 605299) PREDICTED: nuclear rec (1070)  424 48.4 0.00028
NP_001229468 (OMIM: 605299) nuclear receptor coact (1070)  424 48.4 0.00028
NP_055306 (OMIM: 602081,605317) forkhead box prote ( 715)  415 47.6 0.00034
NP_683696 (OMIM: 602081,605317) forkhead box prote ( 740)  415 47.6 0.00034
XP_016868290 (OMIM: 602081,605317) PREDICTED: fork ( 740)  415 47.6 0.00034
XP_006723818 (OMIM: 605299) PREDICTED: nuclear rec (1975)  424 48.7 0.00044
NP_001305169 (OMIM: 605299) nuclear receptor coact (2063)  424 48.7 0.00045
NP_054790 (OMIM: 605299) nuclear receptor coactiva (2063)  424 48.7 0.00045
XP_011528522 (OMIM: 607372) PREDICTED: mediator of ( 406)  401 46.3 0.00047
XP_011528521 (OMIM: 607372) PREDICTED: mediator of ( 406)  401 46.3 0.00047
XP_016884311 (OMIM: 607372) PREDICTED: mediator of ( 406)  401 46.3 0.00047
NP_001166237 (OMIM: 602081,605317) forkhead box pr ( 714)  408 47.0 0.00049
XP_011528520 (OMIM: 607372) PREDICTED: mediator of ( 411)  397 46.0 0.00059
XP_011527023 (OMIM: 605299) PREDICTED: nuclear rec (2068)  418 48.2 0.00062
NP_001170936 (OMIM: 300120,300758) mastermind-like ( 998)  402 46.7 0.00085


>>NP_115803 (OMIM: 607537) mastermind-like protein 2 [Ho  (1156 aa)
 initn: 5259 init1: 4423 opt: 7778  Z-score: 3250.4  bits: 613.4 E(85289): 2.6e-174
Smith-Waterman score: 7778; 99.7% identity (99.7% similar) in 1156 aa overlap (1-1153:1-1156)

               10        20        30        40        50        60
pF1KSD MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
              550       560       570       580       590       600

              610          620       630       640       650       
pF1KSD QQQQQQQQQQQQQQQQQQ---SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
       ::::::::::::::::::   :::::::::::::::::::::::::::::::::::::::
NP_115 QQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
              610       620       630       640       650       660

       660       670       680       690       700       710       
pF1KSD QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
              670       680       690       700       710       720

       720       730       740       750       760       770       
pF1KSD QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
              730       740       750       760       770       780

       780       790       800       810       820       830       
pF1KSD AEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHT
              790       800       810       820       830       840

       840       850       860       870       880       890       
pF1KSD ILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLL
              850       860       870       880       890       900

       900       910       920       930       940       950       
pF1KSD ANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSN
              910       920       930       940       950       960

       960       970       980       990      1000      1010       
pF1KSD TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
              970       980       990      1000      1010      1020

      1020      1030      1040      1050      1060      1070       
pF1KSD TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPP
             1030      1040      1050      1060      1070      1080

      1080      1090      1100      1110      1120      1130       
pF1KSD SLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGND
             1090      1100      1110      1120      1130      1140

      1140      1150   
pF1KSD DWMKDINLDEILGNNS
       ::::::::::::::::
NP_115 DWMKDINLDEILGNNS
             1150      

>>XP_011541325 (OMIM: 607537) PREDICTED: mastermind-like  (1009 aa)
 initn: 4094 init1: 3796 opt: 6613  Z-score: 2767.5  bits: 523.8 E(85289): 2.1e-147
Smith-Waterman score: 6613; 99.7% identity (99.7% similar) in 985 aa overlap (172-1153:25-1009)

             150       160       170       180       190       200 
pF1KSD SNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFL
                                     ::::::::::::::::::::::::::::::
XP_011       MLCESEHQAMIFLCSPKSLQFPQNLQGSLKRKQVVNLSPANSKRPNGFVDNSFL
                     10        20        30        40        50    

             210       220       230       240       250       260 
pF1KSD DIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMG
           60        70        80        90       100       110    

             270       280       290       300       310       320 
pF1KSD LKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPM
          120       130       140       150       160       170    

             330       340       350       360       370       380 
pF1KSD SDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQ
          180       190       200       210       220       230    

             390       400       410       420       430       440 
pF1KSD LRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAA
          240       250       260       270       280       290    

             450       460       470       480       490       500 
pF1KSD NRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVA
          300       310       320       330       340       350    

             510       520       530       540       550       560 
pF1KSD GGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFH
          360       370       380       390       400       410    

             570       580       590       600       610           
pF1KSD FNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ---
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::   
XP_011 FNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
          420       430       440       450       460       470    

      620       630       640       650       660       670        
pF1KSD SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLR
          480       490       500       510       520       530    

      680       690       700       710       720       730        
pF1KSD SPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGY
          540       550       560       570       580       590    

      740       750       760       770       780       790        
pF1KSD MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY
          600       610       620       630       640       650    

      800       810       820       830       840       850        
pF1KSD KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS
          660       670       680       690       700       710    

      860       870       880       890       900       910        
pF1KSD TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
          720       730       740       750       760       770    

      920       930       940       950       960       970        
pF1KSD VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTS
          780       790       800       810       820       830    

      980       990      1000      1010      1020      1030        
pF1KSD AGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTM
          840       850       860       870       880       890    

     1040      1050      1060      1070      1080      1090        
pF1KSD GPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD
          900       910       920       930       940       950    

     1100      1110      1120      1130      1140      1150   
pF1KSD HSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
          960       970       980       990      1000         

>>XP_011541326 (OMIM: 607537) PREDICTED: mastermind-like  (928 aa)
 initn: 3796 init1: 3796 opt: 6246  Z-score: 2615.7  bits: 495.6 E(85289): 5.9e-139
Smith-Waterman score: 6246; 99.7% identity (99.7% similar) in 928 aa overlap (229-1153:1-928)

      200       210       220       230       240       250        
pF1KSD SFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLF
                                     ::::::::::::::::::::::::::::::
XP_011                               MSGTLPMSQAPLRKTNTLPSHTHSPGNGLF
                                             10        20        30

      260       270       280       290       300       310        
pF1KSD NMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISV
               40        50        60        70        80        90

      320       330       340       350       360       370        
pF1KSD PPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSG
              100       110       120       130       140       150

      380       390       400       410       420       430        
pF1KSD SPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQ
              160       170       180       190       200       210

      440       450       460       470       480       490        
pF1KSD IAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMP
              220       230       240       250       260       270

      500       510       520       530       540       550        
pF1KSD GVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKP
              280       290       300       310       320       330

      560       570       580       590       600       610        
pF1KSD LFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
              340       350       360       370       380       390

         620       630       640       650       660       670     
pF1KSD ---SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQP
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQP
              400       410       420       430       440       450

         680       690       700       710       720       730     
pF1KSD LLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTG
              460       470       480       490       500       510

         740       750       760       770       780       790     
pF1KSD SGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPP
              520       530       540       550       560       570

         800       810       820       830       840       850     
pF1KSD PDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMP
              580       590       600       610       620       630

         860       870       880       890       900       910     
pF1KSD SLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSN
              640       650       660       670       680       690

         920       930       940       950       960       970     
pF1KSD NNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEA
              700       710       720       730       740       750

         980       990      1000      1010      1020      1030     
pF1KSD LTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNG
              760       770       780       790       800       810

        1040      1050      1060      1070      1080      1090     
pF1KSD QTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQ
              820       830       840       850       860       870

        1100      1110      1120      1130      1140      1150   
pF1KSD GTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
              880       890       900       910       920        

>>XP_011541327 (OMIM: 607537) PREDICTED: mastermind-like  (735 aa)
 initn: 4823 init1: 4423 opt: 4813  Z-score: 2022.1  bits: 385.4 E(85289): 6.8e-106
Smith-Waterman score: 4813; 97.4% identity (98.0% similar) in 732 aa overlap (1-729:1-732)

               10        20        30        40        50        60
pF1KSD MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
              550       560       570       580       590       600

              610          620       630       640       650       
pF1KSD QQQQQQQQQQQQQQQQQQ---SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
       ::::::::::::::::::   :::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
              610       620       630       640       650       660

       660       670       680       690       700       710       
pF1KSD QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
       :::::::::::::::::::::::::::::::::::::::::::::::::::::.  .:  
XP_011 QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQQPVGVSM
              670       680       690       700       710       720

       720       730       740       750       760       770       
pF1KSD QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
        ..    :   :                                                
XP_011 PDADNIESKCSCKGE                                             
              730                                                  

>>NP_061187 (OMIM: 608991) mastermind-like protein 3 [Ho  (1133 aa)
 initn: 1252 init1: 216 opt: 656  Z-score: 293.8  bits: 66.3 E(85289): 1.3e-09
Smith-Waterman score: 1196; 28.7% identity (54.0% similar) in 1259 aa overlap (7-1151:41-1132)

                                       10              20        30
pF1KSD                         MGDTAPPQAP------AGGLGGASGAGLLGGGSVTP
                                     : ::      ::: ::..: :  ::....:
NP_061 ANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPG--GGSAAVP
               20        30        40        50        60          

               40        50        60        70        80        90
pF1KSD RVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAG
       . ::..::::: ::  ::.::..::.::.....:. . ::..:..: . . . : :.:.:
NP_061 K-HSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLE-QRAKKSG
        70        80        90       100       110        120      

              100       110       120       130       140       150
pF1KSD KHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGI
         :                                        .:::             
NP_061 AGTG---------------------------------------KQQH------------P
        130                                                        

              160       170       180       190       200       210
pF1KSD NGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGE
       .  ::   .. ..::: .:: :: ..:::     :: :. . ::  :..:   .. :. .
NP_061 SKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSK-RIRK
         140       150       160       170       180       190     

              220        230       240        250         260      
pF1KSD NLSAGQGGLQINNGQSQI-MSGTLPMSQAPLRKTNTLP-SHTHSPG--NGLFNMG-LKEV
       ..:::. .  :::  :.. . .. :. :  :. .  :  : ::.::  . : . : : :.
NP_061 DISAGMEA--INNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEI
          200         210       220       230       240       250  

         270       280        290       300       310       320    
pF1KSD KKEPGETLSCSKHMDG-QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDL
       :  : .  .::   :.  . : . . ..  :::    .:     : :.   .:   ..: 
NP_061 KL-PVN--GCSDLEDSFTILQSKDLKQEPLDDP--TCIDTSETSLSNQNKLFSDINLNDQ
               260       270       280         290       300       

          330             340            350       360         370 
pF1KSD ELENMINA---TIKQDDP---FNIDLGQQ-----SQRSTPRPSLPMEKIVIKSE--YSPG
       : ...:.    :. .::    :: :. ..     :: .:  : : .:.  .::.  .:: 
NP_061 EWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETP-LSQESASVKSDPSHSP-
       310       320       330       340        350       360      

             380       390                    400             410  
pF1KSD LTQGPSGSPQLRPPSAGPAFSMANSALS-------------TSSPI------PSVPQS--
       ...   :::: :: :.:: :: ...: :             .:::       :..:..  
NP_061 FAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAH
         370       380       390       400       410       420     

                              420         430       440            
pF1KSD ---QAQPQTGSG-------------ASR--ALPSWQEVSHAQQLKQIAANRQQHARM---
          :: :. :.:             ::   :.:: ...: :.::::.::..::.:..   
NP_061 TPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPS-SDMSPAEQLKQMAAQQQQRAKLMQQ
         430       440       450        460       470       480    

                     450         460       470       480       490 
pF1KSD ----------------QQHQQQH--QPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFS
                       ::.::::  : .::: :   ..:  . :  ::  :: .  :.:.
NP_061 KQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFN
          490       500       510       520       530       540    

             500       510       520       530       540       550 
pF1KSD PQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEP
        :.  .: .:. . :. .: ::.    :.   .:.... :: :..:. . .:. :  .  
NP_061 NQNPIVPPMAN-NLQKTTMNNYL----PQ---NHMNMINQQ-PNNLGTNSLNKQHNIL--
          550        560              570        580       590     

             560       570       580       590       600       610 
pF1KSD RQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQ
         :::::: :::.: .... : :  . ::  :. : ::::::::::::::::::    : 
NP_061 TYGNTKPLTHFNADLSQRMTPPV-ANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQL
           600       610        620       630       640       650  

             620       630       640       650       660       670 
pF1KSD QQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSL
       :  . . :                          ..:..   ..:.  ..:: .  :  :
NP_061 QAPRAHLS--------------------------EDQKRLLLMKQKGVMNQPMAYAA--L
            660                                 670       680      

             680       690       700       710       720       730 
pF1KSD PSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSN
       ::.   . :. : .      ::..   : : .::               : ::.      
NP_061 PSHGQEQHPVGLPRTT--GPMQSSVPPGSGGMVS---------------GASPA------
          690       700         710                      720       

             740         750       760       770        780        
pF1KSD PNTGSGYMNSQQ--SLLNQQLMGKKQTLQRQIMEQKQQLLLQQ-QMLADAEKIAPQDQIN
          : :...::   ....:.:. ..  :   : .::::.: .: :.  . ..:  ..:..
NP_061 ---GPGFLGSQPQAAIMKQMLIDQRAQL---IEQQKQQFLREQRQQQQQQQQILAEQQLQ
                730       740          750       760       770     

      790       800       810       820       830       840        
pF1KSD RHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLST
       .  :. : .. . .::   .: . :..:. . :.   .::  . . :  ... :..... 
NP_061 Q--SHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGI
           780       790       800       810       820       830   

      850       860           870       880       890       900    
pF1KSD SHGTRMPSLSTAV--QNMGM--YGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPM
       . .    ...::.  ..::.  :.. : .::. :....::.:. :. : . .  ..:. .
NP_061 GPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQ
           840       850       860       870       880       890   

          910       920       930         940            950       
pF1KSD MPRPPTLGPSNNNNVATFGAGSVGNSQ--QLRPNLTHSMA-SMP----PQRTSNVMITSN
        :: :. : .. . :. :: . . ::   : .:..   .. ..:    : : ...: : .
NP_061 GPRQPASG-QGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQ
           900        910       920       930       940       950  

       960       970       980       990      1000      1010       
pF1KSD TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
         : .: ..   : :     ..:   : .. :.: : :. :  . .:.: :         
NP_061 QGAQSWQQR---SLQGMPGRTSGELGPFNNGASY-PLQAGQPRLTKQHFPQ---------
            960          970       980        990                  

      1020      1030      1040      1050       1060                
pF1KSD TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNL-NQSGT---------GLN
                  .::..   . : .: ::  :  .. :..:.: .:.::         ::.
NP_061 ----------GLSQSVVDANTGTVRTLN--PAAMGRQMMPSLPGQQGTSQARPMVMSGLS
              1000      1010        1020      1030      1040       

      1070         1080        1090      1100      1110      1120  
pF1KSD QSRTGI---NQPPSLT--PSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSD
       :.  :.   .:::.    ::.  .:...:.:..  .  .:..... ..   .  :.: . 
NP_061 QGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYE-RNAPQDVSYNYSGDGAGGSFPGLPDG
      1050      1060      1070      1080       1090      1100      

           1130      1140      1150   
pF1KSD ADFIDSLLKTEPGNDDWMKDINLDEILGNNS
       ::..::..:  :: :.::..  :::..::  
NP_061 ADLVDSIIKGGPG-DEWMQE--LDELFGNP 
       1110       1120        1130    

>>NP_005111 (OMIM: 300188,300895,305450,309520) mediator  (2177 aa)
 initn: 1190 init1: 408 opt: 566  Z-score: 252.8  bits: 59.6 E(85289): 2.4e-07
Smith-Waterman score: 578; 32.9% identity (54.2% similar) in 474 aa overlap (289-727:1744-2172)

      260       270       280       290       300       310        
pF1KSD NMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNI--
                                     .: .  . :.  :..:: .      :.   
NP_005 VARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPG
          1720      1730      1740      1750      1760      1770   

        320       330       340         350        360       370   
pF1KSD SVPPMSDLELENMINATIKQDDPFNI--DLGQQSQRSTPRP-SLPMEKIVIKSEYSPG--
       ..:: .. : ..  .   :...: .   : :.   :: :   ..: . .    . .::  
NP_005 AAPPSTE-ERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLL---HHPNPGSI
          1780       1790      1800      1810      1820            

                  380        390       400       410        420    
pF1KSD ----LTQGPSG-SPQLRP-PSAGPAFSMANSALSTSSPIPSVPQSQA-QPQTGSGASRAL
             ::  :   : .: :..::  .    .    . .:. :   .  : : .:.    
NP_005 THLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLE
    1830      1840      1850      1860      1870      1880         

          430       440       450       460       470       480    
pF1KSD PSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI----
       ::  ..:  .: .: :. . :  :..:. :: :               : .:: ..    
NP_005 PSSYKTSVYRQ-QQPAVPQGQ--RLRQQLQQSQ---------------GMLGQSSVHQMT
    1890      1900         1910                     1920      1930 

                 490       500       510       520                 
pF1KSD PSPSFGQQT---FSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGH-------LDVL-
       :: :.: ::   ..:  : . :.   .: . .:.   :.. :  :. :       .:   
NP_005 PSSSYGLQTSQGYTPYVSHV-GLQQHTGPAGTMVPPSYSSQPY-QSTHPSTNPTLVDPTR
            1940      1950       1960      1970       1980         

      530       540       550       560       570            580   
pF1KSD -MQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSV-----LPSQNKPSL
        .::.:.    .....  :..     .:. . :    :. :: : .     . .:.  . 
NP_005 HLQQRPS----GYVHQQAPTYGHGLTSTQRFSH----QTLQQTPMISTMTPMSAQGVQAG
    1990          2000      2010          2020      2030      2040 

           590       600       610       620       630       640   
pF1KSD LHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQ
       .. :    .::::::::::::::::::::::::::  :  .::::::  :  ::::::::
NP_005 VRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHI--RQQQQQQ--ILRQQQQQQQQ
            2050      2060      2070        2080        2090       

           650       660       670       680       690       700   
pF1KSD QQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQ
       ::::::::::::::::::. ..:  :. : ::  .:   .:.. : : .:.:  :..  :
NP_005 QQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQ
      2100      2110      2120      2130      2140      2150       

           710       720       730       740       750       760   
pF1KSD VSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIME
       ..::          .:: :.:: :                                    
NP_005 LQQQL---------SNTQPQPSTNIFGRY                               
      2160               2170                                      

>>NP_055572 (OMIM: 605424) mastermind-like protein 1 [Ho  (1016 aa)
 initn: 444 init1: 187 opt: 520  Z-score: 238.0  bits: 55.8 E(85289): 1.6e-06
Smith-Waterman score: 893; 26.7% identity (53.4% similar) in 1179 aa overlap (30-1151:14-1015)

               10        20        30        40        50        60
pF1KSD MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
                                    :: :::..:::: :: .::.:: .::.::: 
NP_055                 MVLPTCPMAEFALPR-HSAVMERLRRRIELCRRHHSTCEARYEA
                               10         20        30        40   

               70        80        90       100       110       120
pF1KSD GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
          :  . ::. :. : .   ... :..:::: .  :..:      : ::::    .:: 
NP_055 VSPERLELERQHTFALHQRCIQAK-AKRAGKHRQPPAATA------PAPAAPAPRLDAAD
            50        60         70        80              90      

              130       140       150       160       170       180
pF1KSD TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
             :  . :   .. :.:...            : .  :::.:.    . :  : ..
NP_055 GPEHGRPATHLHDTVKRNLDSATS------------PQN--GDQQNGYGDLFPGHKKTRR
        100       110       120                     130       140  

              190       200       210       220       230       240
pF1KSD VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
        . :. : :.  ::.   : :  .      .  .:  .:: ..:. ..  :   ...  :
NP_055 EAPLGVAISS--NGLPPASPLGQS------DKPSGADALQ-SSGKHSL--GLDSLNKKRL
            150         160             170        180         190 

              250       260        270        280       290        
pF1KSD RKTNTLPSHTHSPGNGLFNMGL-KEVKKEPGETLSCS-KHMDGQMTQENIFPNRYGDDPG
         ..   .   .:... : ..: ::.:.:: : : :      :...: :..:.       
NP_055 ADSSLHLNGGSNPSES-FPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDL------
             200        210       220       230       240          

      300       310       320       330        340       350       
pF1KSD EQLMDPELQELFNELTNISVPPMSDLELENMINATIKQD-DPFNIDLGQQSQRSTPRPSL
        .: . : .::..:: : :::   : ......:  ...  ::      ..:  .:  :  
NP_055 -NLNEQEWKELIEEL-NRSVP---DEDMKDLFNEDFEEKKDP------ESSGSATQTPL-
           250        260          270       280             290   

       360       370        380       390        400               
pF1KSD PMEKIVIKSEYSPG-LTQGPSGSPQLRPPSAGPAFSMANSA-LSTSSPI-----------
         . : ::.:.::. . :   ::::.:  ::: .:   .:: .::.::            
NP_055 -AQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTS
             300       310       320       330       340       350 

                    410        420            430       440        
pF1KSD -------PS---VPQS-QAQPQTGSGASRALPSW-----QEVSHAQQLKQIAANRQQHAR
              ::   .: : :::    . :. .:::      .:.: :.::.:::: .:.. .
NP_055 GQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAA-KQKREQ
             360       370       380       390       400        410

      450       460          470           480       490        500
pF1KSD MQQHQQQHQPTNWSALPSS---AGPSPG----PFGQEKIPSPSFGQQTFSPQSS-PMPGV
       : :. ::  :.   .  :.   .::: .    :. .::  :::  .: :. ..   ::.:
NP_055 MLQNPQQATPAPAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSV
              420       430       440       450       460       470

              510       520       530       540       550       560
pF1KSD AGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLF
         .: .          .::  : .:...: .: :..:...  ::   ...   :::::: 
NP_055 NKSSPRP---------GGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLD--YGNTKPLS
                       480       490       500       510           

              570       580       590       600       610       620
pF1KSD HFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSS
       :...:  .:  :.   .:.::.:. :  :: .. ...:..   .. .  ..  .     :
NP_055 HYKAD-CGQGSPG--SGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFR-----S
     520        530         540       550       560       570      

              630       640       650       660       670       680
pF1KSD ISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSP
       .    :.:. ::. .: :  .                   : :. . :.:  :.:     
NP_055 LVPPGQEQNPSSVPVQAQATSVG----------------TQPPAVSVASSHNSSP-----
             580       590                       600       610     

              690       700       710       720       730       740
pF1KSD LPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMN
                            :  ::::                           .. :.
NP_055 ---------------------YLSSQQQ---------------------------AAVMK
                                                              620  

              750       760       770        780       790         
pF1KSD SQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQ-MLADAEKIAPQDQINRHLSRPPPDYK
       ..: ::.::    ::  :.:   :.::.: .:: .::. ::    .:..:::.::::.:.
NP_055 QHQLLLDQQ----KQREQQQKHLQQQQFLQRQQHLLAEQEK----QQFQRHLTRPPPQYQ
            630           640       650           660       670    

     800        810       820       830       840       850        
pF1KSD DQRRNVGNM-QPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHG----TRM
       :  .  :.. : ..:..:.:...   .. . .:  :   ..   ..:.  . :    . .
NP_055 DPTQ--GSFPQQVGQFTGSSAAVPGMNTLGPSNS-SCPRVFPQAGNLMPMGPGHASVSSL
            680       690       700        710       720       730 

          860          870       880       890       900       910 
pF1KSD PSLSTAVQNMGMY---GNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTL
       :. ... :. :.    :.    : . :...::..:.. :  :.   :....  .::  ..
NP_055 PT-NSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQ---ATNGHAHIPRQTNV
              740       750       760       770          780       

             920       930           940       950       960       
pF1KSD GPSNNNNVATFGAGSVGNS----QQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQE
       : .:..  :..: .:.:.:    :. . .:. .... :  :.: .:  .:..   :  : 
NP_055 G-QNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSS---WQHQG
        790       800       810       820       830          840   

       970       980       990      1000          1010      1020   
pF1KSD GTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQ----RAVAPPNQLTPAVQM
         . . ..  ...:  :  . ...  .:. .  ..: ::::    : .:: .. . . ..
NP_055 MPNLSGQTPGNSNVS-PFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVGSL
           850        860       870       880       890       900  

          1030      1040      1050      1060      1070      1080   
pF1KSD RPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSN
        :  . .:  .. . .:       :     : ::.:. .:  :.    ...: :. .  .
NP_055 LPPVSAQQRTSAPAPAP-------PPTAPQQGLPGLSPAGPELG----AFSQSPA-SQMG
            910              920       930           940        950

          1090      1100      1110      1120      1130      1140   
pF1KSD FPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDI
         .  . ..:.     ...: : . .: . .   .. . .:.::::::..  ...::.: 
NP_055 GRAGLHCTQAYPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRT-SEEWMSD-
              960       970       980       990      1000          

          1150   
pF1KSD NLDEILGNNS
        ::..::.  
NP_055 -LDDLLGSQ 
      1010       

>>NP_001280163 (OMIM: 607372) mediator of RNA polymerase  (731 aa)
 initn: 986 init1: 378 opt: 506  Z-score: 234.0  bits: 54.6 E(85289): 2.7e-06
Smith-Waterman score: 518; 32.6% identity (53.0% similar) in 451 aa overlap (487-904:75-489)

        460       470       480       490       500       510      
pF1KSD QPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYK
                                     : . :   . . ...:: . . .  . :  
NP_001 VFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIG-MPP
           50        60        70        80        90       100    

        520        530       540       550       560       570     
pF1KSD AGPSAQ-GGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVL
        ::. . ::  ..  . .:..::    ..: :.      ..  .    . :.. :. .: 
NP_001 RGPGQSLGGMGSLGAMGQPMSLS----GQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVA
           110       120           130       140       150         

         580       590          600                    610         
pF1KSD PSQNKPSLLHYTQQQ---QQQQQQQQQQQ--------QQQ-----QQQQQQQQQQQQQQS
        .:.. .     :::   :::::::::::        :::     ::::: :::::::: 
NP_001 LQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQH
     160       170       180       190       200       210         

     620       630       640       650       660       670         
pF1KSD SISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRS
        :. ..:.:::  :. :::: :.  : : :::::::::::::: ..  ::   .:: ...
NP_001 LIKLHHQNQQQ--IQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQ
     220       230         240       250       260       270       

     680       690       700       710       720       730         
pF1KSD PLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYM
       : :  .. : ::.:..       :  :   : :.  :.::  ::  :     :.. .  .
NP_001 PQPPPSQALPQQLQQM----HHTQHHQPPPQPQQPPVAQNQ-PSQLP-----PQSQTQPL
       280       290           300       310             320       

     740       750         760          770            780         
pF1KSD NSQQSLLNQQLMGKKQTLQ--RQIMEQKQ---QLLLQQQMLA-----DAEKIAPQDQINR
        :: . :  :..  .  :.  :  :  .:   :  .:::. :      :. .::  :.. 
NP_001 VSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVQT
       330       340       350       360       370       380       

     790       800       810       820       830       840         
pF1KSD HLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTS
         : :::            ::. :   :. . . :::      ::.    .:.: : : :
NP_001 PQSMPPPP-----------QPSPQ--PGQPSSQPNSN------VSSGPAPSPSSFLPSPS
       390                  400         410             420        

      850       860       870        880         890         900   
pF1KSD -HGTRMPSLSTAVQNMGMYGNLPCNQP-NTYSVTS--GMNQLTQQRNPKQL--LANQNNP
        . .. :  . . ::... .  : : : :  :: :  : .:  .:.   .:  :..  .:
NP_001 PQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEP
      430       440       450       460       470       480        

           910       920       930       940       950       960   
pF1KSD MMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNW
       .                                                           
NP_001 LRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPP
      490       500       510       520       530       540        

>>XP_011537078 (OMIM: 147920,602113) PREDICTED: histone-  (5525 aa)
 initn: 386 init1: 386 opt: 516  Z-score: 226.7  bits: 56.1 E(85289): 6.9e-06
Smith-Waterman score: 631; 25.8% identity (48.4% similar) in 1221 aa overlap (75-1150:3265-4376)

           50        60        70        80        90       100    
pF1KSD AVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTA
                                     : .:: ..:..   ::.. . .   : .  
XP_011 KQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGLAGARQ
         3240      3250      3260      3270      3280      3290    

              110       120       130       140       150          
pF1KSD P--PPP--PAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQ--QPPA
       :  : :  :. ::: .     :    :      .: :.: :...::..:.  .:  ::  
XP_011 PGLPQPLMPTQPPAHALQQRLA----PSMAMVSNQGHML-SGQHGGQAGLVPQQSSQPVL
         3300      3310          3320       3330      3340         

      160       170       180        190           200             
pF1KSD STPGDQRNSALIALQGSLKRKQVVNLSP-ANSKRPNG----FVDNSFLD-----------
       :    :.  . .  .  .: .:..  .  :::  :.     :. ....:           
XP_011 S----QKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALK
    3350          3360      3370      3380      3390      3400     

                               210        220         230          
pF1KSD -IKRI----RVG--------------ENLSAGQGG-LQ--INNGQSQIMSGTLP------
        ::..     .:              . ::.: .. ::  .  :..:  :.  :      
XP_011 GIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQERSAGDPSQPRPN
        3410      3420      3430      3440      3450      3460     

                  240       250       260       270            280 
pF1KSD --------MSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPG-----ETLSCSKHMDG
               ...:  :. .    ::..    :..: :: .... :     .   :.:.  .
XP_011 PPTFAQGVINEADQRQYEEWLFHTQQ----LLQMQLKVLEEQIGVHRKSRKALCAKQRTA
        3470      3480      3490          3500      3510      3520 

             290       300       310       320       330       340 
pF1KSD QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFN
       . . .. ::.  .:    .:.  . ... ..: ..        .:  : .   ::..  .
XP_011 KKAGRE-FPE--ADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNL--MAEYRNKQQQQQQ
             3530        3540      3550      3560        3570      

             350       360       370       380          390        
pF1KSD IDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPP---SAGPAFSMANSAL
        .  ::.:.:.     : ..  . ..    :  : . .:   ::   ..:  .. .. ::
XP_011 QQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMAL
       3580      3590      3600      3610      3620      3630      

      400           410       420       430       440              
pF1KSD STSSPIP----SVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAAN------RQ---Q
         .   :    .. :.: : ..:...: : ::         :.... .      ::   :
XP_011 PGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQ
       3640      3650      3660      3670      3680      3690      

         450            460              470             480       
pF1KSD HARMQ-----QHQQQHQPTNWSALPSSA-------GPSP------GPFGQEKIPSPSFGQ
       . :::     :.:::.:  .   : . :       ::.       ::  :  .: ::  :
XP_011 QQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP-PSSHQ
       3700      3710      3720      3730      3740      3750      

       490         500       510        520       530              
pF1KSD QTFSPQSSPMP--GVAGGSGQSKVMANYMYKAGP-SAQGGHLDVLMQQK-----PQD---
         .  : ::.:  :  :  : ..: .  . . :  . :: : .::: :.     ::    
XP_011 GLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQ
        3760      3770      3780      3790      3800      3810     

            540       550          560       570       580         
pF1KSD ----LSRSFINNPHPAMEPR---QGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQ
           ... ...  .  .. .   ::.   : :....  ...    : .:   :: .  ::
XP_011 GQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQ
        3820      3830      3840      3850      3860      3870     

     590       600       610       620       630       640         
pF1KSD QQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQ
       :: ::::: ::::::: ::::: :::: :     :::::::  .. ::::: :::::: :
XP_011 QQLQQQQQLQQQQQQQLQQQQQLQQQQLQ-----QQQQQQQ--LQQQQQQQLQQQQQQLQ
        3880      3890      3900           3910        3920        

     650       660       670       680       690        700        
pF1KSD QQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIA-GMGYQVSQQQ
       ::::::::: ::: ..:    : ..  : ::         ::.:.: .: : :. ..  :
XP_011 QQQQQQQQQFQQQQQQQQMGLLNQSRTLLSP---------QQQQQQQVALGPGMPAKPLQ
     3930      3940      3950               3960      3970         

      710                720        730       740       750        
pF1KSD RQDQHSVVG---------QNT-GPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQ
       . .. ...:         :::  :. : .   .:.: .:   .  .   ...  .   ..
XP_011 HFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTT-PESMATEPGEVK
    3980      3990      4000      4010      4020       4030        

      760       770       780       790       800       810        
pF1KSD RQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGS
        ..  ..: ::.: :         :: : .    .::     :...  ..  ::   ::.
XP_011 PSLSGDSQLLLVQPQ---------PQPQPSSLQLQPPLRLPGQQQQQVSLLHTA---GGG
     4040      4050               4060      4070      4080         

      820       830       840       850       860       870        
pF1KSD STISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTY
       :  .:.:...              :   :. :   .::.:     .:       .::...
XP_011 SHGQLGSGSS--------------SEASSVPHLLAQPSVS-----LG-------DQPGSM
       4090                    4100      4110                  4120

      880       890       900       910       920       930        
pF1KSD SVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLT
       .    .: :  :. :      :::   :.::  ::  ... .  :.: . .  ::: .: 
XP_011 T----QNLLGPQQ-PMLERPMQNNTG-PQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQ
                  4130      4140       4150      4160      4170    

      940             950         960       970       980          
pF1KSD HSMASMP------PQRTSNV--MITSNTTAPNWASQEGTSKQQEALTSAGVRF-----PT
         .:. :      ::. ...  .. .     . : ..    :. .  .. ..      : 
XP_011 GVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQ
         4180      4190      4200      4210      4220      4230    

           990       1000      1010      1020      1030      1040  
pF1KSD --GTPAAYT-PNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLR
         : :.  : : : :  :    :   :  :::. :. .  . :..      . :   : :
XP_011 LGGFPGPQTGPLQELG-AGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQE--PKR
         4240      4250       4260      4270      4280        4290 

           1050         1060      1070      1080      1090         
pF1KSD GLNLRPNQL---STQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDH
            :.::   :.: ::.  :    :  .. :  .: .  :.  : :.. : :      
XP_011 -----PSQLPSPSSQ-LPTEAQ----LPPTHPGTPKPQG--PTLEPPPGRVSPA------
                 4300           4310      4320        4330         

    1100      1110      1120      1130      1140      1150         
pF1KSD SSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS      
       ...::  ..:.   ..::      :  :.: .:.  ... .   .::.. :         
XP_011 AAQLADTLFSK---GLGPW-----DPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQL
          4340              4350      4360      4370      4380     

XP_011 SIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQ
        4390      4400      4410      4420      4430      4440     

>>XP_006719679 (OMIM: 147920,602113) PREDICTED: histone-  (5536 aa)
 initn: 386 init1: 386 opt: 516  Z-score: 226.7  bits: 56.1 E(85289): 6.9e-06
Smith-Waterman score: 631; 25.8% identity (48.4% similar) in 1221 aa overlap (75-1150:3292-4403)

           50        60        70        80        90       100    
pF1KSD AVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTA
                                     : .:: ..:..   ::.. . .   : .  
XP_006 KQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGLAGARQ
            3270      3280      3290      3300      3310      3320 

              110       120       130       140       150          
pF1KSD P--PPP--PAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQ--QPPA
       :  : :  :. ::: .     :    :      .: :.: :...::..:.  .:  ::  
XP_006 PGLPQPLMPTQPPAHALQQRLA----PSMAMVSNQGHML-SGQHGGQAGLVPQQSSQPVL
            3330      3340          3350       3360      3370      

      160       170       180        190           200             
pF1KSD STPGDQRNSALIALQGSLKRKQVVNLSP-ANSKRPNG----FVDNSFLD-----------
       :    :.  . .  .  .: .:..  .  :::  :.     :. ....:           
XP_006 S----QKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALK
           3380      3390      3400      3410      3420      3430  

                               210        220         230          
pF1KSD -IKRI----RVG--------------ENLSAGQGG-LQ--INNGQSQIMSGTLP------
        ::..     .:              . ::.: .. ::  .  :..:  :.  :      
XP_006 GIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQERSAGDPSQPRPN
           3440      3450      3460      3470      3480      3490  

                  240       250       260       270            280 
pF1KSD --------MSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPG-----ETLSCSKHMDG
               ...:  :. .    ::..    :..: :: .... :     .   :.:.  .
XP_006 PPTFAQGVINEADQRQYEEWLFHTQQ----LLQMQLKVLEEQIGVHRKSRKALCAKQRTA
           3500      3510          3520      3530      3540        

             290       300       310       320       330       340 
pF1KSD QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFN
       . . .. ::.  .:    .:.  . ... ..: ..        .:  : .   ::..  .
XP_006 KKAGRE-FPE--ADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNL--MAEYRNKQQQQQQ
     3550         3560      3570      3580      3590        3600   

             350       360       370       380          390        
pF1KSD IDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPP---SAGPAFSMANSAL
        .  ::.:.:.     : ..  . ..    :  : . .:   ::   ..:  .. .. ::
XP_006 QQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMAL
          3610      3620      3630      3640      3650      3660   

      400           410       420       430       440              
pF1KSD STSSPIP----SVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAAN------RQ---Q
         .   :    .. :.: : ..:...: : ::         :.... .      ::   :
XP_006 PGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQ
          3670      3680      3690      3700      3710      3720   

         450            460              470             480       
pF1KSD HARMQ-----QHQQQHQPTNWSALPSSA-------GPSP------GPFGQEKIPSPSFGQ
       . :::     :.:::.:  .   : . :       ::.       ::  :  .: ::  :
XP_006 QQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP-PSSHQ
          3730      3740      3750      3760      3770       3780  

       490         500       510        520       530              
pF1KSD QTFSPQSSPMP--GVAGGSGQSKVMANYMYKAGP-SAQGGHLDVLMQQK-----PQD---
         .  : ::.:  :  :  : ..: .  . . :  . :: : .::: :.     ::    
XP_006 GLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQ
           3790      3800      3810      3820      3830      3840  

            540       550          560       570       580         
pF1KSD ----LSRSFINNPHPAMEPR---QGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQ
           ... ...  .  .. .   ::.   : :....  ...    : .:   :: .  ::
XP_006 GQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQ
           3850      3860      3870      3880      3890      3900  

     590       600       610       620       630       640         
pF1KSD QQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQ
       :: ::::: ::::::: ::::: :::: :     :::::::  .. ::::: :::::: :
XP_006 QQLQQQQQLQQQQQQQLQQQQQLQQQQLQ-----QQQQQQQ--LQQQQQQQLQQQQQQLQ
           3910      3920      3930             3940      3950     

     650       660       670       680       690        700        
pF1KSD QQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIA-GMGYQVSQQQ
       ::::::::: ::: ..:    : ..  : ::         ::.:.: .: : :. ..  :
XP_006 QQQQQQQQQFQQQQQQQQMGLLNQSRTLLSP---------QQQQQQQVALGPGMPAKPLQ
        3960      3970      3980               3990      4000      

      710                720        730       740       750        
pF1KSD RQDQHSVVG---------QNT-GPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQ
       . .. ...:         :::  :. : .   .:.: .:   .  .   ...  .   ..
XP_006 HFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTT-PESMATEPGEVK
       4010      4020      4030      4040      4050       4060     

      760       770       780       790       800       810        
pF1KSD RQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGS
        ..  ..: ::.: :         :: : .    .::     :...  ..  ::   ::.
XP_006 PSLSGDSQLLLVQPQ---------PQPQPSSLQLQPPLRLPGQQQQQVSLLHTA---GGG
        4070      4080               4090      4100      4110      

      820       830       840       850       860       870        
pF1KSD STISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTY
       :  .:.:...              :   :. :   .::.:     .:       .::...
XP_006 SHGQLGSGSS--------------SEASSVPHLLAQPSVS-----LG-------DQPGSM
          4120                    4130           4140              

      880       890       900       910       920       930        
pF1KSD SVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLT
       .    .: :  :. :      :::   :.::  ::  ... .  :.: . .  ::: .: 
XP_006 T----QNLLGPQQ-PMLERPMQNNTG-PQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQ
          4150       4160       4170      4180      4190      4200 

      940             950         960       970       980          
pF1KSD HSMASMP------PQRTSNV--MITSNTTAPNWASQEGTSKQQEALTSAGVRF-----PT
         .:. :      ::. ...  .. .     . : ..    :. .  .. ..      : 
XP_006 GVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQ
            4210      4220      4230      4240      4250      4260 

           990       1000      1010      1020      1030      1040  
pF1KSD --GTPAAYT-PNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLR
         : :.  : : : :  :    :   :  :::. :. .  . :..      . :   : :
XP_006 LGGFPGPQTGPLQELG-AGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQE--PKR
            4270       4280      4290      4300      4310          

           1050         1060      1070      1080      1090         
pF1KSD GLNLRPNQL---STQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDH
            :.::   :.: ::.  :    :  .. :  .: .  :.  : :.. : :      
XP_006 -----PSQLPSPSSQ-LPTEAQ----LPPTHPGTPKPQG--PTLEPPPGRVSPA------
          4320       4330          4340        4350      4360      

    1100      1110      1120      1130      1140      1150         
pF1KSD SSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS      
       ...::  ..:.   ..::      :  :.: .:.  ... .   .::.. :         
XP_006 AAQLADTLFSK---GLGPW-----DPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQL
             4370              4380      4390      4400      4410  

XP_006 SIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQ
           4420      4430      4440      4450      4460      4470  




1153 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 19:10:59 2016 done: Thu Nov  3 19:11:01 2016
 Total Scan time: 17.370 Total Display time:  0.290

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com